PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3174788-2	1988	Tert-butylhydroperoxide (tBOOH), cumene hydroperoxide (CuOOH), benzoyl hydroperoxide (BOOH) and hydrogen peroxide reacted with BSA, decreasing the titratable SH group concentration and increasing the value of the ratio between the reaction rate and the concentration of albumin SH groups in the sulfhydryl-disulfide exchange reaction.	tert-Butylhydroperoxide	0-23	albumin	Rattus norvegicus	127-130
3174788-2	1988	Tert-butylhydroperoxide (tBOOH), cumene hydroperoxide (CuOOH), benzoyl hydroperoxide (BOOH) and hydrogen peroxide reacted with BSA, decreasing the titratable SH group concentration and increasing the value of the ratio between the reaction rate and the concentration of albumin SH groups in the sulfhydryl-disulfide exchange reaction.	tert-Butylhydroperoxide	25-30	albumin	Rattus norvegicus	127-130
2828540-1	1987	Folic acid is degraded by cytochrome c in the presence of hydrogen peroxide/tert-butyl hydroperoxide at the C9-N10 bond.	tert-Butylhydroperoxide	76-100	cytochrome c, somatic	Homo sapiens	26-38
3349570-2	1988	These effects were observed concomitantly with a diminution in the content of cytochrome P-450 and microsomal functions related to oxidative and free-radical mediated reactions, namely, NADPH oxidase activity, NADPH-dependent oxygen uptake and NADPH-or t-butyl hydroperoxide-induced chemiluminescence.	tert-Butylhydroperoxide	253-274	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	78-94
3021818-5	1986	Although activators of guanylate cyclase such as atriopeptin III, sodium nitroprusside, and tert-butylhydroperoxide increase cyclic GMP levels by approximately 2-3-fold, they do not stimulate or modulate PGI2 production.	tert-Butylhydroperoxide	92-115	5'-nucleotidase, cytosolic II	Homo sapiens	132-135
3117053-3	1987	t-Butylhydroperoxide markedly promoted permeabilization in the presence of Ca2+ but not in its absence, and Ca2+-plus-t-butylhydroperoxide-induced permeabilization was reversed by EGTA.	tert-Butylhydroperoxide	0-20	carbonic anhydrase 2	Rattus norvegicus	75-78
3666282-0	1987	Altered thiol group status in the heart ornithine decarboxylase inactivated following perfusion with t-butylhydroperoxide.	tert-Butylhydroperoxide	101-121	ornithine decarboxylase 1	Rattus norvegicus	40-63
3666282-4	1987	After t-butylhydroperoxide infusion, the isoproterenol-stimulated heart ODC was strongly inhibited.	tert-Butylhydroperoxide	6-26	ornithine decarboxylase 1	Rattus norvegicus	72-75
3666282-9	1987	The hearts perfused with 1 mM acetylcysteine after 15 min of perfusion with t-butylhydroperoxide recovered almost completely the initial ODC activity.	tert-Butylhydroperoxide	76-96	ornithine decarboxylase 1	Rattus norvegicus	137-140
3673705-6	1987	The stimulation of flux through the pentose phosphate pathway during the metabolism of t-butyl hydroperoxide is presented, and the increase in cellular activity of glucose-6-phosphate dehydrogenase is correlated with the increase in the level of protSSG.	tert-Butylhydroperoxide	87-108	glucose-6-phosphate dehydrogenase	Homo sapiens	164-197
3087771-1	1986	The administration to rats of either t-butyl hydroperoxide or phenobarbital, compounds that are metabolized through detoxification processes, produces an increase in specific activity of the NADPH-consuming enzymes, glutathione reductase and NADPH-cytochrome c reductase.	tert-Butylhydroperoxide	37-58	glutathione-disulfide reductase	Rattus norvegicus	216-237
2945286-1	1986	The metabolism of tert.-butyl hydroperoxide (TBHP) by the glutathione peroxidase/reductase system in isolated hepatocytes results in the rapid depletion of reduced glutathione and NADPH.	tert-Butylhydroperoxide	45-49	telomerase reverse transcriptase	Rattus norvegicus	18-22
3726880-1	1986	Metabolism of tert-butyl hydroperoxide (TBHP, 2.0 mM) by glutathione peroxidase within isolated rat hepatocytes caused a rapid oxidation of intracellular reduced glutathione and ultimately NADPH through glutathione reductase.	tert-Butylhydroperoxide	14-38	glutathione-disulfide reductase	Rattus norvegicus	203-224
3726880-1	1986	Metabolism of tert-butyl hydroperoxide (TBHP, 2.0 mM) by glutathione peroxidase within isolated rat hepatocytes caused a rapid oxidation of intracellular reduced glutathione and ultimately NADPH through glutathione reductase.	tert-Butylhydroperoxide	40-44	glutathione-disulfide reductase	Rattus norvegicus	203-224
2423127-0	1986	t-Butylhydroperoxide-induced Ca2+ efflux from liver mitochondria in the presence of physiological concentrations of Mg2+ and ATP.	tert-Butylhydroperoxide	0-20	carbonic anhydrase 2	Rattus norvegicus	29-32
6090141-3	1984	Impairment of mitochondrial Ca2+ homeostasis by pyridine nucleotide oxidation associated with tert-butyl hydroperoxide metabolism, prevents the ATP-dependent cellular Ca2+ accumulation and causes a release of Ca2+ from the hepatocytes into the medium.	tert-Butylhydroperoxide	94-118	carbonic anhydrase 2	Rattus norvegicus	28-31
3718986-2	1986	Exposure of human erythrocytes to t-butyl hydroperoxide (0.5-1.0 mM) results in oxidation of glutathione, formation of malonyldialdehyde, and oxidation of hemoglobin to methemoglobin.	tert-Butylhydroperoxide	34-55	hemoglobin subunit gamma 2	Homo sapiens	169-182
3718986-6	1986	In cells pre-treated with NaNO2 to convert hemoglobin to methemoglobin, t-butyl hydroperoxide reduces [9,10-3H]oleic acid incorporation into phosphatidylcholine by erythrocytes but does not stimulate [9,10-3H]oleic acid incorporation into phosphatidylethanolamine.	tert-Butylhydroperoxide	72-93	hemoglobin subunit gamma 2	Homo sapiens	57-70
3995035-3	1985	As increased hemoglobin oxidation occurred in the erythrocytes, membrane lipid peroxidation diminished, suggesting a protective role for methemoglobin in t-butyl hydroperoxide-induced lipid peroxidation.	tert-Butylhydroperoxide	154-175	hemoglobin subunit gamma 2	Homo sapiens	137-150
6090141-3	1984	Impairment of mitochondrial Ca2+ homeostasis by pyridine nucleotide oxidation associated with tert-butyl hydroperoxide metabolism, prevents the ATP-dependent cellular Ca2+ accumulation and causes a release of Ca2+ from the hepatocytes into the medium.	tert-Butylhydroperoxide	94-118	carbonic anhydrase 2	Rattus norvegicus	167-170
6090141-3	1984	Impairment of mitochondrial Ca2+ homeostasis by pyridine nucleotide oxidation associated with tert-butyl hydroperoxide metabolism, prevents the ATP-dependent cellular Ca2+ accumulation and causes a release of Ca2+ from the hepatocytes into the medium.	tert-Butylhydroperoxide	94-118	carbonic anhydrase 2	Rattus norvegicus	167-170
6817329-4	1982	When NADPH oxidation was prevented by selective inactivation of glutathione reductase, t-butyl hydroperoxide metabolism was without effect on the mitochondrial Ca2+ pool, whereas the loss from the extramitochondrial pool was accelerated.	tert-Butylhydroperoxide	87-108	glutathione-disulfide reductase	Homo sapiens	64-85
6692829-2	1984	In the present study freshly isolated rat hepatocytes treated with the glutathione reductase inhibitor BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) were used to investigate the metabolism of tert-butyl hydroperoxide and of hydrogen peroxide formed in different intracellular compartments.	tert-Butylhydroperoxide	190-214	glutathione-disulfide reductase	Rattus norvegicus	71-92
6629334-8	1983	In livers from fasted rats the activity of glucose-6-phosphate dehydrogenase was increased by 34% by t-butyl hydroperoxide infusion.	tert-Butylhydroperoxide	101-122	glucose-6-phosphate dehydrogenase	Rattus norvegicus	43-76
6177691-2	1982	Ca2+ release from mitochondria induced by oxalacetate or t-butyl hydroperoxide is accompanied by loss of endogenous Mg2+ and K+, swelling, loss of membrane potential, and other alterations which indicate that Ca2+ release is a result of increased inner membrane permeability.	tert-Butylhydroperoxide	57-78	mucin 7, secreted	Homo sapiens	116-119
6177691-6	1982	Under these conditions subsequent swelling and Mg2+ loss are inhibited.l Ultrastructural observations show the mitochondria become permeable in response to Ca2+ plus oxalacetate or Ca2+ plus t-butyl hydroperoxide in a heterogeneous manner.	tert-Butylhydroperoxide	191-212	mucin 7, secreted	Homo sapiens	47-50
6797006-2	1981	Differential distribution of cytochrome P450 and prostaglandin endoperoxide synthetase and each enzyme"s preference for either cumene hydroperoxide or T-butyl hydroperoxide enabled the present investigation to distinguish their respective contributions in the cooxidative activation of paracetamol.	tert-Butylhydroperoxide	151-172	cytochrome P-450	Oryctolagus cuniculus	29-44
4460-7	1976	Tert-butyl hydroperoxide (2 X 10(-3) M), a glutathione-oxidizing reagent, inhibited degradation by 35 to 50%, possibly due to an effect on a glutathione-insulin transhydrogenase.	tert-Butylhydroperoxide	0-24	insulin	Homo sapiens	153-160
7430093-9	1980	These results, which indicate that the reaction proceeds via an Ordered Bi Bi mechanism in which p-nitroanisole binds to the enzyme prior to the binding of t-butyl hydroperoxide, are discussed in relationship to the peroxidase-type mechanism which has been suggested for the action of cytochrome P-450.	tert-Butylhydroperoxide	156-177	cytochrome P-450	Oryctolagus cuniculus	285-301
6250533-3	1980	Chemiluminescence depended linearly on cytochrome c concentration, and optimal light-emission was observed at [t-butyl hydroperoxide]/[ferricytochrome c] ratios of 160-500.	tert-Butylhydroperoxide	111-132	cytochrome c, somatic	Homo sapiens	39-51
34025428-4	2021	In vitro, downregulation of miR-327 inhibited both H/R- and TBHP-induced oxidative stress, and suppressed apoptosis.	tert-Butylhydroperoxide	60-64	microRNA 327	Rattus norvegicus	28-35
33662571-5	2021	Silencing of GPx4 by RNA interference and exposure to tert-butyl hydroperoxide (tert-BHP) caused ferroptosis in rat pancreatic beta-cells as evidenced by non-apoptotic cell death in association with increased lipid peroxidation, disturbed ATP synthesis, reduced GSH content, and GPx4 degradation.	tert-Butylhydroperoxide	54-78	glutathione peroxidase 4	Rattus norvegicus	279-283
33662571-5	2021	Silencing of GPx4 by RNA interference and exposure to tert-butyl hydroperoxide (tert-BHP) caused ferroptosis in rat pancreatic beta-cells as evidenced by non-apoptotic cell death in association with increased lipid peroxidation, disturbed ATP synthesis, reduced GSH content, and GPx4 degradation.	tert-Butylhydroperoxide	80-88	glutathione peroxidase 4	Rattus norvegicus	13-17
33662571-5	2021	Silencing of GPx4 by RNA interference and exposure to tert-butyl hydroperoxide (tert-BHP) caused ferroptosis in rat pancreatic beta-cells as evidenced by non-apoptotic cell death in association with increased lipid peroxidation, disturbed ATP synthesis, reduced GSH content, and GPx4 degradation.	tert-Butylhydroperoxide	80-88	glutathione peroxidase 4	Rattus norvegicus	279-283
33662571-6	2021	GPx4 overexpression as well as the ferroptosis inhibitor ferrostatin-1 effectively attenuated beta-cell death induced by tert-BHP.	tert-Butylhydroperoxide	121-129	glutathione peroxidase 4	Rattus norvegicus	0-4
34020031-9	2021	RESULTS: We found that the expression of STING was upregulated in human and rat degenerated NP tissue as well as in TBHP-treated NP cells.	tert-Butylhydroperoxide	116-120	stimulator of interferon response cGAMP interactor 1	Homo sapiens	41-46
34020031-10	2021	Overexpression of STING promoted the degradation of extracellular matrix; it also promoted apoptosis and senescence of TBHP-treated and untreated NP cells.	tert-Butylhydroperoxide	119-123	stimulator of interferon response cGAMP interactor 1	Rattus norvegicus	18-23
33511552-12	2021	Taken together, activation of HSP70 could protect against t-BHP-induced NPSC apoptosis and senescence, thus, improving the quantity and quality of NPSCs.	tert-Butylhydroperoxide	58-63	heat shock protein family A (Hsp70) member 4	Homo sapiens	30-35
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	28-52	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
33895140-7	2021	Mutation of any of the four cysteines in PRDX4 altered the HMW species in response to TBuOOH, as well as the secretion of PRDX4.	tert-Butylhydroperoxide	86-92	peroxiredoxin 4	Homo sapiens	41-46
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	28-52	mitogen-activated protein kinase 8	Homo sapiens	150-153
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	28-52	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-159
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	54-59	heat shock protein family A (Hsp70) member 4	Homo sapiens	14-19
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	54-59	mitogen-activated protein kinase 8	Homo sapiens	150-153
33511552-0	2021	Activation of HSP70 impedes tert-butyl hydroperoxide (t-BHP)-induced apoptosis and senescence of human nucleus pulposus stem cells via inhibiting the JNK/c-Jun pathway.	tert-Butylhydroperoxide	54-59	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	154-159
33511552-7	2021	The results suggested that HSP70 impeded t-BHP-mediated cell viability loss and protected the ultrastructure of NPSCs.	tert-Butylhydroperoxide	41-46	heat shock protein family A (Hsp70) member 4	Homo sapiens	27-32
33833406-9	2022	Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1.	tert-Butylhydroperoxide	184-188	calcitonin-related polypeptide alpha	Rattus norvegicus	27-58
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	tert-Butylhydroperoxide	163-167	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	76-83
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	tert-Butylhydroperoxide	163-167	matrix metallopeptidase 13	Homo sapiens	88-93
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	tert-Butylhydroperoxide	163-167	caspase 3	Homo sapiens	126-135
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	tert-Butylhydroperoxide	163-167	cytochrome c, somatic	Homo sapiens	137-149
33880054-11	2021	Results: Our results showed that hydrogen can inhibit inflammatory factors (ADAMTS5 and MMP13) and apoptosis factors (cleaved caspase-3, cytochrome c, and Bax) in TBHP-induced chondrocytes.	tert-Butylhydroperoxide	163-167	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158
33891955-7	2021	The expression of nuclear factor erythroid 2-related factor-2 (Nrf2) was activated in RPE cells by t-BHP accompanied with an activation of Erk1/2 signaling.	tert-Butylhydroperoxide	99-104	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
33833406-9	2022	Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1.	tert-Butylhydroperoxide	184-188	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
33833406-9	2022	Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1.	tert-Butylhydroperoxide	184-188	myoglobin	Rattus norvegicus	223-225
33833406-9	2022	Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1.	tert-Butylhydroperoxide	184-188	calcitonin-related polypeptide alpha	Rattus norvegicus	265-269
33833406-9	2022	Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1.	tert-Butylhydroperoxide	184-188	NFE2 like bZIP transcription factor 2	Rattus norvegicus	305-309
33833406-9	2022	Furthermore, we found that calcitonin gene-related peptide (CGRP), a neural inflammatory mediator, was accumulated around the vessel in synovium and subchondral bone in OA rats and in TBHP-treated primary cortical neurons; MB administration significantly inhibited CGRP expression through upregulation of Nrf2 and PRDX1.	tert-Butylhydroperoxide	184-188	peroxiredoxin 1	Rattus norvegicus	314-319
33744850-1	2021	The aim of this study was to determine the effect of HDAC6 inhibition using the selective inhibitor Tubastatin A (TubA) on the regulation of tert-butyl hydroperoxide (TBHP)-treated chondrocytes and a mouse OA model.	tert-Butylhydroperoxide	141-165	histone deacetylase 6	Mus musculus	53-58
33909255-10	2021	The antioxidant proteins of HSP70, Mn-SOD, and catalase and the matrix proteins of aggrecan and collagen II decreased remarkably with the stimulation of TBHP, while the matrix metalloproteinase-13 (MMP-13) significantly increased after TBHP intervention.	tert-Butylhydroperoxide	153-157	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	28-33
33909255-10	2021	The antioxidant proteins of HSP70, Mn-SOD, and catalase and the matrix proteins of aggrecan and collagen II decreased remarkably with the stimulation of TBHP, while the matrix metalloproteinase-13 (MMP-13) significantly increased after TBHP intervention.	tert-Butylhydroperoxide	153-157	superoxide dismutase 2	Rattus norvegicus	35-55
33537813-11	2021	On the whole, the present study demonstrates that TBHP-induced oxidative stress stimulates ER interactions and CH apoptosis, which are suppressed by exogenous H2S via modulating the GRP78/mTOR signaling pathway.	tert-Butylhydroperoxide	50-54	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	182-187
33537813-11	2021	On the whole, the present study demonstrates that TBHP-induced oxidative stress stimulates ER interactions and CH apoptosis, which are suppressed by exogenous H2S via modulating the GRP78/mTOR signaling pathway.	tert-Butylhydroperoxide	50-54	mechanistic target of rapamycin kinase	Rattus norvegicus	188-192
32892384-8	2021	Ferritinophagy, nuclear receptor coactivator 4 (NCOA4)-mediated ferritin selective autophagy, is originated during the process of ferroptosis in response to TBHP treatment.	tert-Butylhydroperoxide	157-161	nuclear receptor coactivator 4	Homo sapiens	16-46
32892384-8	2021	Ferritinophagy, nuclear receptor coactivator 4 (NCOA4)-mediated ferritin selective autophagy, is originated during the process of ferroptosis in response to TBHP treatment.	tert-Butylhydroperoxide	157-161	nuclear receptor coactivator 4	Homo sapiens	48-53
32892384-9	2021	Knockdown and overexpression NCOA4 further prove TBHP may induce ferroptosis of AFCs and NPCs in an autophagy-dependent way.	tert-Butylhydroperoxide	49-53	nuclear receptor coactivator 4	Homo sapiens	29-34
33744850-1	2021	The aim of this study was to determine the effect of HDAC6 inhibition using the selective inhibitor Tubastatin A (TubA) on the regulation of tert-butyl hydroperoxide (TBHP)-treated chondrocytes and a mouse OA model.	tert-Butylhydroperoxide	167-171	histone deacetylase 6	Mus musculus	53-58
33744850-2	2021	Using conventional molecular biology methods, our results showed that the level of HDAC6 increases both in the cartilage of osteoarthritis (OA) mice and TBHP-treated chondrocytes in vitro.	tert-Butylhydroperoxide	153-157	histone deacetylase 6	Mus musculus	83-88
33714955-4	2021	In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure.	tert-Butylhydroperoxide	165-189	eukaryotic translation initiation factor 2A	Homo sapiens	40-50
33714955-4	2021	In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure.	tert-Butylhydroperoxide	165-189	activating transcription factor 4	Homo sapiens	51-55
33714955-4	2021	In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure.	tert-Butylhydroperoxide	165-189	DNA damage inducible transcript 3	Homo sapiens	56-60
33714955-4	2021	In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure.	tert-Butylhydroperoxide	191-195	eukaryotic translation initiation factor 2A	Homo sapiens	40-50
33714955-4	2021	In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure.	tert-Butylhydroperoxide	191-195	activating transcription factor 4	Homo sapiens	51-55
33714955-4	2021	In this study, we demonstrated that the eIF2-alpha/ATF4/CHOP branch of unfolded protein response (UPR) was activated in human trabecular meshwork cells (HTMCs) upon tert-butyl hydroperoxide (TBHP) exposure.	tert-Butylhydroperoxide	191-195	DNA damage inducible transcript 3	Homo sapiens	56-60
33714955-5	2021	Inhibition of ATF4 ameliorated TBHP-induced apoptosis and inflammatory cytokine production, while ectopic expression of ATF4 increased the expression of endothelial leukocyte adhesion molecule (ELAM)-1 and IL-8 in HTMCs.	tert-Butylhydroperoxide	31-35	activating transcription factor 4	Homo sapiens	14-18
33568697-2	2021	Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (ADA-409-052) inhibits tert-Butyl hydroperoxide (TBHP)-induced lipid peroxidation (LP) and protects against ferroptotic cell death triggered by glutathione (GSH) depletion or glutathione peroxidase 4 (GPx4) inhibition in neuronal cell lines.	tert-Butylhydroperoxide	126-150	glutathione peroxidase 4	Mus musculus	278-302
33568697-2	2021	Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (ADA-409-052) inhibits tert-Butyl hydroperoxide (TBHP)-induced lipid peroxidation (LP) and protects against ferroptotic cell death triggered by glutathione (GSH) depletion or glutathione peroxidase 4 (GPx4) inhibition in neuronal cell lines.	tert-Butylhydroperoxide	126-150	glutathione peroxidase 4	Mus musculus	304-308
33568697-2	2021	Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (ADA-409-052) inhibits tert-Butyl hydroperoxide (TBHP)-induced lipid peroxidation (LP) and protects against ferroptotic cell death triggered by glutathione (GSH) depletion or glutathione peroxidase 4 (GPx4) inhibition in neuronal cell lines.	tert-Butylhydroperoxide	152-156	glutathione peroxidase 4	Mus musculus	278-302
33568697-2	2021	Here we show that a condensed benzo[b]thiazine derivative small molecule with an arylthiazine backbone (ADA-409-052) inhibits tert-Butyl hydroperoxide (TBHP)-induced lipid peroxidation (LP) and protects against ferroptotic cell death triggered by glutathione (GSH) depletion or glutathione peroxidase 4 (GPx4) inhibition in neuronal cell lines.	tert-Butylhydroperoxide	152-156	glutathione peroxidase 4	Mus musculus	304-308
33536712-0	2021	Upregulation and stabilization of senescence marker protein-30 by epigallocatechin gallate against tert-butyl hydroperoxide-induced liver injury in vitro and in vivo.	tert-Butylhydroperoxide	99-123	regucalcin	Mus musculus	34-62
33603950-7	2021	Nrf2 knockdown abolished the antioxidative stress and antiapoptotic effects of ANPODRT in NP cells treated with TBHP.	tert-Butylhydroperoxide	112-116	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
33197516-7	2021	Moreover, in TBHP-treated NSC34 cells, trehalose promoted the expression of autophage-related markers (LC3 and Beclin-1), concomitant with decreased levels of apoptosis.	tert-Butylhydroperoxide	13-17	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	103-106
33197516-7	2021	Moreover, in TBHP-treated NSC34 cells, trehalose promoted the expression of autophage-related markers (LC3 and Beclin-1), concomitant with decreased levels of apoptosis.	tert-Butylhydroperoxide	13-17	beclin 1, autophagy related	Mus musculus	111-119
33340764-6	2021	The effects of PWRN2 downregulation or upregulation on t-BuOOH-induced cell death, cellular apoptosis and mitochondrial injuries were then quantitatively evaluated.	tert-Butylhydroperoxide	55-62	Prader-Willi region non-protein coding RNA 2	Homo sapiens	15-20
33340764-9	2021	Quantitative assays demonstrated that, PWRN2 downregulation effectively alleviated t-BuOOH-induced cell death, apoptosis and various-type of mitochondrial injuries.	tert-Butylhydroperoxide	83-90	Prader-Willi region non-protein coding RNA 2	Homo sapiens	39-44
33340764-10	2021	On the other hand, PWRN2 upregulation worsened t-BuOOH-induced cellular damages in ARPE-19 cells.	tert-Butylhydroperoxide	47-54	Prader-Willi region non-protein coding RNA 2	Homo sapiens	19-24
32347047-3	2021	The purpose of the current study was to evaluate the effect of arbutin on tert-butyl hydroperoxide (t-BHP)-induced oxidative stress and the related mechanisms in fibroblast and Lymph Node Carcinoma of the Prostate (LNCaP) cells.	tert-Butylhydroperoxide	100-105	telomerase reverse transcriptase	Homo sapiens	74-78
33536712-5	2021	Furthermore, treatment of cells with tert-butyl hydroperoxide (tert-BHP), an oxidative promoter, decreased SMP30 expression and ERK1/2 phosphorylation, while EGCg treatment inhibited these effects.	tert-Butylhydroperoxide	37-61	regucalcin	Rattus norvegicus	107-112
33536712-5	2021	Furthermore, treatment of cells with tert-butyl hydroperoxide (tert-BHP), an oxidative promoter, decreased SMP30 expression and ERK1/2 phosphorylation, while EGCg treatment inhibited these effects.	tert-Butylhydroperoxide	37-61	mitogen-activated protein kinase 3	Mus musculus	128-134
33536712-5	2021	Furthermore, treatment of cells with tert-butyl hydroperoxide (tert-BHP), an oxidative promoter, decreased SMP30 expression and ERK1/2 phosphorylation, while EGCg treatment inhibited these effects.	tert-Butylhydroperoxide	63-71	regucalcin	Rattus norvegicus	107-112
33536712-5	2021	Furthermore, treatment of cells with tert-butyl hydroperoxide (tert-BHP), an oxidative promoter, decreased SMP30 expression and ERK1/2 phosphorylation, while EGCg treatment inhibited these effects.	tert-Butylhydroperoxide	63-71	mitogen-activated protein kinase 3	Mus musculus	128-134
33536712-8	2021	The tert-BHP-administered mice showed decreased SMP30 expression in the liver and increased aspartate aminotransferase and alanine transaminase (hepatic injury marker enzymes) activities; however, EGCg treatment attenuated these changes.	tert-Butylhydroperoxide	4-12	regucalcin	Mus musculus	48-53
33536712-9	2021	Thus, EGCg-induced SMP30 upregulation may alleviate tert-BHP-induced liver injury.	tert-Butylhydroperoxide	52-60	regucalcin	Mus musculus	19-24
33321464-7	2021	Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas.	tert-Butylhydroperoxide	70-93	nfe2 like bZIP transcription factor 2a	Danio rerio	0-5
33321464-7	2021	Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas.	tert-Butylhydroperoxide	70-93	nfe2 like bZIP transcription factor 2a	Danio rerio	118-123
33321464-7	2021	Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas.	tert-Butylhydroperoxide	70-93	nfe2 like bZIP transcription factor 2a	Danio rerio	118-123
33321464-7	2021	Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas.	tert-Butylhydroperoxide	70-93	nfe2 like bZIP transcription factor 2a	Danio rerio	118-123
33321464-7	2021	Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas.	tert-Butylhydroperoxide	237-260	nfe2 like bZIP transcription factor 2a	Danio rerio	0-5
33321464-9	2021	The 10-min high (776 muM) tert-butylhydroperoxide exposure (induced Nrf2a globally) decreased global protein glutathionylation at 96 hpf.	tert-Butylhydroperoxide	26-49	nfe2 like bZIP transcription factor 2a	Danio rerio	68-73
33321464-10	2021	Mutant fish expressing inactive Nrf2a were protected against tert-butylhydroperoxide-induced abnormal islet morphology.	tert-Butylhydroperoxide	61-84	nfe2 like bZIP transcription factor 2a	Danio rerio	32-37
32812103-0	2020	Protective effect of coumarin-pi against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via enhanced Nrf2 signaling.	tert-Butylhydroperoxide	41-46	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
33300520-3	2020	The tert-butyl hydroperoxide (t-BHP) exposure aging model bone mesenchymal stem cells (BMSCs) were reverted by using a poly-hybrid scaffold (PS), which is a carbon nanotube (CNT) coated polycaprolactone (PCL) and polylactic acid (PLA) scaffold, combined with insulin-like growth factor-1 (IGF).	tert-Butylhydroperoxide	30-35	insulin like growth factor 1	Homo sapiens	259-287
33300520-3	2020	The tert-butyl hydroperoxide (t-BHP) exposure aging model bone mesenchymal stem cells (BMSCs) were reverted by using a poly-hybrid scaffold (PS), which is a carbon nanotube (CNT) coated polycaprolactone (PCL) and polylactic acid (PLA) scaffold, combined with insulin-like growth factor-1 (IGF).	tert-Butylhydroperoxide	30-35	insulin like growth factor 1	Homo sapiens	289-292
33146011-1	2020	An efficient, safe, and environmentally friendly tertiary butyl hydrogen peroxide (TBHP)-mediated rearrangement of aryl/alkylidene malononitrile with anilines has been developed with in situ generation of HCN as the cyanide source for the synthesis of substituted alpha-aminonitriles and alpha-aminoamide.	tert-Butylhydroperoxide	83-87	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	205-208
33649728-0	2020	The Effects of Pre-Treatment and Post-Treatment of Thymol against tert-Butyl Hydroperoxide (t-BHP) Cytotoxicity in MCF-7 Cell Line and Fibroblast Derived Foreskin.	tert-Butylhydroperoxide	92-97	solute carrier family 35 member G1	Homo sapiens	33-37
33202651-8	2020	Moreover, this (DM + deP) method was used to detect the phosphorylation degree change of Ser82 on the Hsp27 protein of HepG2 cells caused by tert-butyl hydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	141-165	heat shock protein family B (small) member 1	Homo sapiens	102-107
33202651-8	2020	Moreover, this (DM + deP) method was used to detect the phosphorylation degree change of Ser82 on the Hsp27 protein of HepG2 cells caused by tert-butyl hydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	167-172	heat shock protein family B (small) member 1	Homo sapiens	102-107
33204066-13	2020	In addition, acacetin relieved the TBHP-induced generation of inflammatory mediators (COX-2, iNOS) and degradation of the extracellular matrix (aggrecan, collagen II, MMP13, MMP9, and MMP3).	tert-Butylhydroperoxide	35-39	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	86-91
33204066-13	2020	In addition, acacetin relieved the TBHP-induced generation of inflammatory mediators (COX-2, iNOS) and degradation of the extracellular matrix (aggrecan, collagen II, MMP13, MMP9, and MMP3).	tert-Butylhydroperoxide	35-39	nitric oxide synthase 2	Rattus norvegicus	93-97
33204066-13	2020	In addition, acacetin relieved the TBHP-induced generation of inflammatory mediators (COX-2, iNOS) and degradation of the extracellular matrix (aggrecan, collagen II, MMP13, MMP9, and MMP3).	tert-Butylhydroperoxide	35-39	matrix metallopeptidase 13	Rattus norvegicus	167-172
33204066-13	2020	In addition, acacetin relieved the TBHP-induced generation of inflammatory mediators (COX-2, iNOS) and degradation of the extracellular matrix (aggrecan, collagen II, MMP13, MMP9, and MMP3).	tert-Butylhydroperoxide	35-39	matrix metallopeptidase 3	Rattus norvegicus	184-188
33095946-8	2021	CONCLUSIONS: In conclusion, CP and SP attenuates the loss of contractility due to UVA damage, inhibits t-BuOOH-induced ROS formation and improves expression of ECM component genes.	tert-Butylhydroperoxide	103-110	ceruloplasmin	Homo sapiens	28-30
33027770-4	2020	SAC increased the nuclear translocation of Nrf2 and activated the Nrf2/HO1 signaling pathway in TBHP-treated chondrocytes.	tert-Butylhydroperoxide	96-100	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
33027770-4	2020	SAC increased the nuclear translocation of Nrf2 and activated the Nrf2/HO1 signaling pathway in TBHP-treated chondrocytes.	tert-Butylhydroperoxide	96-100	heme oxygenase 1	Mus musculus	71-74
33027770-5	2020	Furthermore, Nrf2 knockdown abrogated the antiapoptotic, antisenescence, and ECM regulatory effects of SAC in TBHP-treated chondrocytes.	tert-Butylhydroperoxide	110-114	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
33027770-7	2020	Collectively, these findings show that SAC ameliorates OA pathology in TBHP-treated chondrocytes and DMM model mice by activating the Nrf2/HO1 signaling pathway.	tert-Butylhydroperoxide	71-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	134-138
33027770-7	2020	Collectively, these findings show that SAC ameliorates OA pathology in TBHP-treated chondrocytes and DMM model mice by activating the Nrf2/HO1 signaling pathway.	tert-Butylhydroperoxide	71-75	heme oxygenase 1	Mus musculus	139-142
32542535-6	2020	Exposure to 50 muM TBHP increased caspase 3/7 activity, an indicator of apoptosis, after 8 and 24 h. Antioxidant treatment markedly reduced TBHP-stimulated caspase 3/7 activity, PGE2 release, and IL-6 release.	tert-Butylhydroperoxide	19-23	caspase 3	Homo sapiens	34-45
32542535-6	2020	Exposure to 50 muM TBHP increased caspase 3/7 activity, an indicator of apoptosis, after 8 and 24 h. Antioxidant treatment markedly reduced TBHP-stimulated caspase 3/7 activity, PGE2 release, and IL-6 release.	tert-Butylhydroperoxide	19-23	interleukin 6	Homo sapiens	196-200
32542535-6	2020	Exposure to 50 muM TBHP increased caspase 3/7 activity, an indicator of apoptosis, after 8 and 24 h. Antioxidant treatment markedly reduced TBHP-stimulated caspase 3/7 activity, PGE2 release, and IL-6 release.	tert-Butylhydroperoxide	140-144	caspase 3	Homo sapiens	34-45
32542535-6	2020	Exposure to 50 muM TBHP increased caspase 3/7 activity, an indicator of apoptosis, after 8 and 24 h. Antioxidant treatment markedly reduced TBHP-stimulated caspase 3/7 activity, PGE2 release, and IL-6 release.	tert-Butylhydroperoxide	140-144	interleukin 6	Homo sapiens	196-200
32542535-7	2020	TBHP-stimulated IL-6 release was blocked by PD169316 but unaltered by indomethacin.	tert-Butylhydroperoxide	0-4	interleukin 6	Homo sapiens	16-20
32542535-8	2020	These data suggest that TBHP-stimulated IL-6 release and caspase 3/7 activation were independent of PGE2 yet were interrupted by treatments with known antioxidant properties, providing new insight into relationships between PGE2, IL-6, and apoptosis under conditions of chemically induced cellular oxidation.	tert-Butylhydroperoxide	24-28	interleukin 6	Homo sapiens	40-44
32542535-8	2020	These data suggest that TBHP-stimulated IL-6 release and caspase 3/7 activation were independent of PGE2 yet were interrupted by treatments with known antioxidant properties, providing new insight into relationships between PGE2, IL-6, and apoptosis under conditions of chemically induced cellular oxidation.	tert-Butylhydroperoxide	24-28	caspase 3	Homo sapiens	57-68
32542535-8	2020	These data suggest that TBHP-stimulated IL-6 release and caspase 3/7 activation were independent of PGE2 yet were interrupted by treatments with known antioxidant properties, providing new insight into relationships between PGE2, IL-6, and apoptosis under conditions of chemically induced cellular oxidation.	tert-Butylhydroperoxide	24-28	interleukin 6	Homo sapiens	230-234
32652517-5	2020	PHC Nrf2-dependently alleviated tert-butyl hydroperoxide-induced reactive oxygen species production in alveolar macrophages.	tert-Butylhydroperoxide	32-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	4-8
32901466-9	2020	However, compared to the wildtype (WT) cells, exposure to either tBHP or ROT enhanced the production of ROS, ECAR, and the proton (H+) production rate (PPR) from glycolysis, as well as promoted apoptotic cell death in VDAC1-/- H9c2 cells.	tert-Butylhydroperoxide	65-69	voltage-dependent anion channel 1	Rattus norvegicus	218-223
32901466-11	2020	Restoration of VDAC1 in VDAC1-/- H9c2 cells reinstated mitochondria-bound HKII and concomitantly decreased tBHP and ROT-induced ROS production and cell death.	tert-Butylhydroperoxide	107-111	voltage-dependent anion channel 1	Rattus norvegicus	15-20
32901466-11	2020	Restoration of VDAC1 in VDAC1-/- H9c2 cells reinstated mitochondria-bound HKII and concomitantly decreased tBHP and ROT-induced ROS production and cell death.	tert-Butylhydroperoxide	107-111	voltage-dependent anion channel 1	Rattus norvegicus	24-29
32901466-12	2020	Interestingly, mitochondrial respiration remained the same after tBHP treatment in VDAC1-/- and WT H9c2 cells.	tert-Butylhydroperoxide	65-69	voltage-dependent anion channel 1	Rattus norvegicus	83-88
32276028-7	2020	Both mutations increased the cytotoxic activity of IL-13 on human SH-SY5Y neurons exposed to sublethal doses of hydrogen peroxide, t-butyl hydroperoxide or RLS3, an inducer of ferroptosis.	tert-Butylhydroperoxide	131-152	interleukin 13	Homo sapiens	51-56
32554208-5	2020	NaB also reduced the TBHP-induced release of proteases that degrade the extracellular matrix, including matrix metalloproteinases 3 and 13, and ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs 4).	tert-Butylhydroperoxide	21-25	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	144-152
32554208-5	2020	NaB also reduced the TBHP-induced release of proteases that degrade the extracellular matrix, including matrix metalloproteinases 3 and 13, and ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs 4).	tert-Butylhydroperoxide	21-25	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	154-218
32554208-6	2020	Intriguingly, NaB significantly reversed TBHP-induced klotho suppression.	tert-Butylhydroperoxide	41-45	klotho	Homo sapiens	54-60
32554208-11	2020	Therefore, NaB alleviates TBHP-induced oxidative stress in human NPCs by elevating PPARgamma-regulated klotho expression.	tert-Butylhydroperoxide	26-30	peroxisome proliferator activated receptor gamma	Homo sapiens	83-92
32554208-11	2020	Therefore, NaB alleviates TBHP-induced oxidative stress in human NPCs by elevating PPARgamma-regulated klotho expression.	tert-Butylhydroperoxide	26-30	klotho	Homo sapiens	103-109
32806014-5	2020	We find that CdS nanorod provides the selective oxidation of HMF to FFCA in the presence of dimethyl sulfoxide solvent and tert-butyl hydrogen peroxide oxidizing agent.	tert-Butylhydroperoxide	123-151	CDP-diacylglycerol synthase 1	Homo sapiens	13-16
32471991-7	2020	Furthermore, TGF-beta1 increased reactive oxygen species (ROS) levels in PLC/PRF/5 cells and enhanced tert-butyl hydroperoxide-induced ROS levels in Huh7 cells; these changes were reversed by xCT overexpression.	tert-Butylhydroperoxide	102-126	transforming growth factor beta 1	Homo sapiens	13-22
32238418-5	2020	Here, we investigated the ability of the major human drug-metabolizing P450s, namely CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2, to use different OSs: H2O2; tert-butyl hydroperoxide (tert-BuOOH); CuOOH; (diacetoxyiodo)benzene (BAIB); and bis(trifluoroacetoxy)iodobenzene (F-BAIB).	tert-Butylhydroperoxide	157-181	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	85-91
32238418-5	2020	Here, we investigated the ability of the major human drug-metabolizing P450s, namely CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2, to use different OSs: H2O2; tert-butyl hydroperoxide (tert-BuOOH); CuOOH; (diacetoxyiodo)benzene (BAIB); and bis(trifluoroacetoxy)iodobenzene (F-BAIB).	tert-Butylhydroperoxide	157-181	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	93-99
32238418-5	2020	Here, we investigated the ability of the major human drug-metabolizing P450s, namely CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2, to use different OSs: H2O2; tert-butyl hydroperoxide (tert-BuOOH); CuOOH; (diacetoxyiodo)benzene (BAIB); and bis(trifluoroacetoxy)iodobenzene (F-BAIB).	tert-Butylhydroperoxide	157-181	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	101-108
32238418-5	2020	Here, we investigated the ability of the major human drug-metabolizing P450s, namely CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2, to use different OSs: H2O2; tert-butyl hydroperoxide (tert-BuOOH); CuOOH; (diacetoxyiodo)benzene (BAIB); and bis(trifluoroacetoxy)iodobenzene (F-BAIB).	tert-Butylhydroperoxide	183-193	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	85-91
32238418-5	2020	Here, we investigated the ability of the major human drug-metabolizing P450s, namely CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2, to use different OSs: H2O2; tert-butyl hydroperoxide (tert-BuOOH); CuOOH; (diacetoxyiodo)benzene (BAIB); and bis(trifluoroacetoxy)iodobenzene (F-BAIB).	tert-Butylhydroperoxide	183-193	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	93-99
32238418-5	2020	Here, we investigated the ability of the major human drug-metabolizing P450s, namely CYP3A4, CYP2C9, CYP2C19, CYP2D6 and CYP1A2, to use different OSs: H2O2; tert-butyl hydroperoxide (tert-BuOOH); CuOOH; (diacetoxyiodo)benzene (BAIB); and bis(trifluoroacetoxy)iodobenzene (F-BAIB).	tert-Butylhydroperoxide	183-193	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	101-108
32471991-7	2020	Furthermore, TGF-beta1 increased reactive oxygen species (ROS) levels in PLC/PRF/5 cells and enhanced tert-butyl hydroperoxide-induced ROS levels in Huh7 cells; these changes were reversed by xCT overexpression.	tert-Butylhydroperoxide	102-126	MIR7-3 host gene	Homo sapiens	149-153
32471991-7	2020	Furthermore, TGF-beta1 increased reactive oxygen species (ROS) levels in PLC/PRF/5 cells and enhanced tert-butyl hydroperoxide-induced ROS levels in Huh7 cells; these changes were reversed by xCT overexpression.	tert-Butylhydroperoxide	102-126	solute carrier family 7 member 11	Homo sapiens	192-195
32415938-0	2020	Jatrorrhizine Hydrochloride alleviates tert-butyl hydroperoxide-induced endothelial cell injury through its anti-inflammatory activity and PPAR-gamma activation.	tert-Butylhydroperoxide	39-63	peroxisome proliferator activated receptor gamma	Mus musculus	139-149
31920129-6	2020	Levels of O-linked beta-N-acetylglucosamine (O-GlcNAc), AKT, and pAKT were evaluated by Western blotting.Results: O-GlcNAc augmentation by PUGNAc increased cell viability, attenuated the loss of DeltaPsim, and intracellular ROS against tBHP-induced oxidative stress (p < .05).	tert-Butylhydroperoxide	236-240	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	114-122
32454932-4	2020	We used the imaging flow cytometry to demonstrate that tert-butyl hydroperoxide (t-BHP) induces mitochondrial-mediated apoptosis and ROS production in RAW264.7 cells.	tert-Butylhydroperoxide	81-86	telomerase reverse transcriptase	Mus musculus	55-59
31920129-7	2020	O-GlcNAc augmentation reduced tBHP-induced mitochondrial calcium overload (p < .05) while it did not have any effect on intracellular calcium overload with tBHP.	tert-Butylhydroperoxide	30-34	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	0-8
32162522-9	2020	Compound 2 was found to catalyze the oxidation of cyclohexane to cyclohexanol and cyclohexanone with H2O2 (a mixture of these products was obtained after adding PPh3 to the reaction solution) as well as the transformation of cyclohexanol to cyclohexanone under the action of tert-butyl hydroperoxide.	tert-Butylhydroperoxide	275-299	caveolin 1	Homo sapiens	161-165
32331354-7	2020	The protective effect of crocetin is mediated via the preservation of energy production pathways and activation of ERK1/2 in the first minutes of TBHP exposure to potentiate survival pathways.	tert-Butylhydroperoxide	146-150	mitogen-activated protein kinase 3	Homo sapiens	115-121
32377518-0	2020	Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway.	tert-Butylhydroperoxide	36-41	thymoma viral proto-oncogene 1	Mus musculus	108-111
32377518-0	2020	Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway.	tert-Butylhydroperoxide	36-41	forkhead box O1	Mus musculus	112-117
32377518-10	2020	BXXD promoted the phosphorylation of AKT and FOXO1 in t-BHP-induced MIN6 cells.	tert-Butylhydroperoxide	54-59	thymoma viral proto-oncogene 1	Mus musculus	37-40
32377518-10	2020	BXXD promoted the phosphorylation of AKT and FOXO1 in t-BHP-induced MIN6 cells.	tert-Butylhydroperoxide	54-59	forkhead box O1	Mus musculus	45-50
32377518-13	2020	Conclusion: BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM).	tert-Butylhydroperoxide	46-51	thymoma viral proto-oncogene 1	Mus musculus	141-144
32377518-13	2020	Conclusion: BXXD protected MIN6 cells against t-BHP-induced apoptosis and improved insulin secretory function through modulation of the PI3K/AKT pathway and the downstream FOXO1, thus suggesting a novel therapeutic approach for type 2 diabetes mellitus (T2DM).	tert-Butylhydroperoxide	46-51	forkhead box O1	Mus musculus	172-177
31839625-6	2020	t-BHP increased the expression of iron importers, transferrin receptor-1 and divalent metal transporter-1, and iron regulatory protein 1 and 2.	tert-Butylhydroperoxide	0-5	aconitase 1	Homo sapiens	111-142
32266254-7	2020	Moreover, FGF2 also alleviated the excessive ER stress and apoptosis in cultured NRK-52E cells injured by tert-Butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	106-130	fibroblast growth factor 2	Rattus norvegicus	10-14
32266254-7	2020	Moreover, FGF2 also alleviated the excessive ER stress and apoptosis in cultured NRK-52E cells injured by tert-Butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	132-136	fibroblast growth factor 2	Rattus norvegicus	10-14
32031753-1	2020	Herein we disclosed the utilization of remote "imidazole" based precatalyst [( para -cymene)Ru II (L)Cl] + , C-1 where L = 2-(4-substituted-phenyl)-1H-imidazo[4,5-f][1,10] phenanthroline) for the selective oxidation of variety of alkyl arenes/heteroarenes and alcohols to their corresponding aldehydes or ketones in presence of tert -butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	328-353	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	109-112
32031753-1	2020	Herein we disclosed the utilization of remote "imidazole" based precatalyst [( para -cymene)Ru II (L)Cl] + , C-1 where L = 2-(4-substituted-phenyl)-1H-imidazo[4,5-f][1,10] phenanthroline) for the selective oxidation of variety of alkyl arenes/heteroarenes and alcohols to their corresponding aldehydes or ketones in presence of tert -butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	355-359	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	109-112
31839625-8	2020	t-BHP increased the phosphorylation of JNK and STAT4, the primary up-stream activators of SP-1, but Dex decreased this.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase 8	Homo sapiens	39-42
31839625-8	2020	t-BHP increased the phosphorylation of JNK and STAT4, the primary up-stream activators of SP-1, but Dex decreased this.	tert-Butylhydroperoxide	0-5	signal transducer and activator of transcription 4	Homo sapiens	47-52
31926268-5	2020	Mfn2 knockdown aggravated the impairment of autophagic flux, mitochondrial dysfunction and cellular apoptosis in rat NPCs after Tert-Butyl hydroperoxide (TBHP) treatment, while Mfn2 overexpression significantly reversed these alterations.	tert-Butylhydroperoxide	128-152	mitofusin 2	Rattus norvegicus	0-4
31926268-5	2020	Mfn2 knockdown aggravated the impairment of autophagic flux, mitochondrial dysfunction and cellular apoptosis in rat NPCs after Tert-Butyl hydroperoxide (TBHP) treatment, while Mfn2 overexpression significantly reversed these alterations.	tert-Butylhydroperoxide	154-158	mitofusin 2	Rattus norvegicus	0-4
31926268-6	2020	Besides, Mfn2 overexpression promoted an ROS (reactive oxygen species)-dependent mitophagy via PINK1 (PTEN-induced putative kinase protein 1)/Parkin pathway in TBHP-treated NPCs.	tert-Butylhydroperoxide	160-164	mitofusin 2	Rattus norvegicus	9-13
31926268-6	2020	Besides, Mfn2 overexpression promoted an ROS (reactive oxygen species)-dependent mitophagy via PINK1 (PTEN-induced putative kinase protein 1)/Parkin pathway in TBHP-treated NPCs.	tert-Butylhydroperoxide	160-164	PTEN induced kinase 1	Rattus norvegicus	95-100
31926268-6	2020	Besides, Mfn2 overexpression promoted an ROS (reactive oxygen species)-dependent mitophagy via PINK1 (PTEN-induced putative kinase protein 1)/Parkin pathway in TBHP-treated NPCs.	tert-Butylhydroperoxide	160-164	PTEN induced kinase 1	Rattus norvegicus	102-140
31893419-2	2020	Tert-butyl hydroperoxide (tBHP) was used for oxidative stress, and verapamil was used as reduction agent on red blood cells (RBCs).	tert-Butylhydroperoxide	26-30	telomerase reverse transcriptase	Homo sapiens	0-4
31858786-7	2020	Nrf2a LOF mutants showed increased sensitivity to the acute toxicity of cumene hydroperoxide (CHP) and tBHP throughout the first four days of development.	tert-Butylhydroperoxide	103-107	nfe2 like bZIP transcription factor 2a	Danio rerio	0-5
32116715-5	2020	The protective effect of FGF10 against apoptosis and ER stress was recapitulated by in vitro experiments using oxidative damaged NRK-52E cells induced by tert-Butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	154-178	fibroblast growth factor 10	Rattus norvegicus	25-30
32116715-5	2020	The protective effect of FGF10 against apoptosis and ER stress was recapitulated by in vitro experiments using oxidative damaged NRK-52E cells induced by tert-Butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	180-184	fibroblast growth factor 10	Rattus norvegicus	25-30
31870798-10	2020	MACE revealed that genes related to progression of G2/M cell cycle including Foxm1, Aurka, Plk1, and Ccnb1 were significantly down-regulated in tBHP and HDACi-treated HepG2 cells.	tert-Butylhydroperoxide	144-148	forkhead box M1	Homo sapiens	77-82
31870798-10	2020	MACE revealed that genes related to progression of G2/M cell cycle including Foxm1, Aurka, Plk1, and Ccnb1 were significantly down-regulated in tBHP and HDACi-treated HepG2 cells.	tert-Butylhydroperoxide	144-148	aurora kinase A	Homo sapiens	84-89
31870798-10	2020	MACE revealed that genes related to progression of G2/M cell cycle including Foxm1, Aurka, Plk1, and Ccnb1 were significantly down-regulated in tBHP and HDACi-treated HepG2 cells.	tert-Butylhydroperoxide	144-148	polo like kinase 1	Homo sapiens	91-95
31870798-10	2020	MACE revealed that genes related to progression of G2/M cell cycle including Foxm1, Aurka, Plk1, and Ccnb1 were significantly down-regulated in tBHP and HDACi-treated HepG2 cells.	tert-Butylhydroperoxide	144-148	cyclin B1	Homo sapiens	101-106
31672277-5	2020	In the present study, we found that tert-butyl hydroperoxide or antimycin A induced more cell death in LAMP2 knockdown (LAMP2-KD) than in control ARPE-19 cells.	tert-Butylhydroperoxide	36-60	lysosomal associated membrane protein 2	Homo sapiens	103-108
31672277-5	2020	In the present study, we found that tert-butyl hydroperoxide or antimycin A induced more cell death in LAMP2 knockdown (LAMP2-KD) than in control ARPE-19 cells.	tert-Butylhydroperoxide	36-60	lysosomal associated membrane protein 2	Homo sapiens	120-125
31772142-6	2019	Additionally, Ast alleviated TNF-alpha-induced ECM degradation and chondrocyte apoptosis by inhibiting the NF-kappaB signaling, suppressed TBHP-induced oxidative stress, and subsequently reduced chondrocyte apoptosis.	tert-Butylhydroperoxide	139-143	tumor necrosis factor	Mus musculus	29-38
31631212-0	2019	tert-Butyl peroxide (TBHP)/KI-mediated dual C(sp2)-H bond amination of arylamines with alpha-diazo carbonyls toward 1,2,4-benzotriazines.	tert-Butylhydroperoxide	21-25	Sp2 transcription factor	Homo sapiens	44-49
31657383-2	2019	Optically active 1,1-bi-2-naphthol derivatives can be synthesized in high yields when a 2 : 1 complex of (S)-xylyl-iPrO-BIPHEP-oxide and Fe(OTf)2 is used in the presence of t-butyl hydroperoxide as an oxidant.	tert-Butylhydroperoxide	173-194	POU class 2 homeobox 2	Homo sapiens	140-145
31740659-7	2019	Interestingly, TBHP resulted in mitophagy through the inhibition of the HIF-1alpha/NDUFA4L2 pathway.	tert-Butylhydroperoxide	15-19	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-82
31740659-7	2019	Interestingly, TBHP resulted in mitophagy through the inhibition of the HIF-1alpha/NDUFA4L2 pathway.	tert-Butylhydroperoxide	15-19	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	83-91
31631212-1	2019	A new radical-induced dehydrogenative heterocyclization of arylamines with alpha-diazo carbonyls has been established under metal-free oxidative conditions, enabling two-fold C(sp2)-H bond amination to access a wide range of functionalized 1,2,4-triazine derivatives with generally good yields by combining KI/tert-butyl peroxide (TBHP).	tert-Butylhydroperoxide	331-335	Sp2 transcription factor	Homo sapiens	175-180
31238070-5	2019	Here, the expression of SIRT2 was detected in AF cells exposed to tert-Butyl hydroperoxide (TBHP) by western blotting.	tert-Butylhydroperoxide	66-90	sirtuin 2	Sus scrofa	24-29
31635261-6	2019	In cellular models for oxidative stress, HME counteracted membrane lipid oxidation of human erythrocytes stimulated by tert-butyl hydroperoxide and prevented the generation of reactive oxygen species, as well as the GSH decay in IL-1beta-activated intestinal normal-like cells.	tert-Butylhydroperoxide	119-143	interleukin 1 beta	Homo sapiens	229-237
31295412-3	2019	Here, we investigated the effect of H2 on free-radical-induced cytotoxicity using tert-butyl hydroperoxide in a human acute monocytic leukemia cell line, THP-1.	tert-Butylhydroperoxide	82-106	GLI family zinc finger 2	Homo sapiens	154-159
31478545-3	2019	Proteinuria, abnormalities in the renal tubules and KIM1 activation were found in tBHP intoxicated animals.	tert-Butylhydroperoxide	82-86	hepatitis A virus cellular receptor 1	Mus musculus	52-56
31671682-1	2019	In this study, cell death induced by the oxidant tert-butylhydroperoxide (tBH) was observed in U2OS cells; this phenotype was rescued by Syntaxin 17 (STX17) knockout (KO) but the mechanism is unknown.	tert-Butylhydroperoxide	49-72	syntaxin 17	Homo sapiens	137-148
31671682-1	2019	In this study, cell death induced by the oxidant tert-butylhydroperoxide (tBH) was observed in U2OS cells; this phenotype was rescued by Syntaxin 17 (STX17) knockout (KO) but the mechanism is unknown.	tert-Butylhydroperoxide	49-72	syntaxin 17	Homo sapiens	150-155
31671682-1	2019	In this study, cell death induced by the oxidant tert-butylhydroperoxide (tBH) was observed in U2OS cells; this phenotype was rescued by Syntaxin 17 (STX17) knockout (KO) but the mechanism is unknown.	tert-Butylhydroperoxide	74-77	syntaxin 17	Homo sapiens	137-148
31671682-1	2019	In this study, cell death induced by the oxidant tert-butylhydroperoxide (tBH) was observed in U2OS cells; this phenotype was rescued by Syntaxin 17 (STX17) knockout (KO) but the mechanism is unknown.	tert-Butylhydroperoxide	74-77	syntaxin 17	Homo sapiens	150-155
31749701-9	2019	Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.	tert-Butylhydroperoxide	56-60	NFE2 like bZIP transcription factor 2	Homo sapiens	151-155
31749701-9	2019	Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.	tert-Butylhydroperoxide	56-60	heme oxygenase 1	Homo sapiens	157-173
31749701-9	2019	Mechanistically, we found that GAS protects HUVECs from TBHP-induced cellular apoptosis by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.	tert-Butylhydroperoxide	56-60	heme oxygenase 1	Homo sapiens	175-179
31472963-4	2019	In contrast, Prx2 was highly sensitive to the relatively hydrophobic oxidants, such as tert-butyl hydroperoxide (t-BHP) and cumene hydroperoxide.	tert-Butylhydroperoxide	87-111	peroxiredoxin 2	Homo sapiens	13-17
31472963-4	2019	In contrast, Prx2 was highly sensitive to the relatively hydrophobic oxidants, such as tert-butyl hydroperoxide (t-BHP) and cumene hydroperoxide.	tert-Butylhydroperoxide	113-118	peroxiredoxin 2	Homo sapiens	13-17
31472963-6	2019	The t-BHP treatment formed hyperoxidized Prx2 in a dose-dependent manner.	tert-Butylhydroperoxide	4-9	peroxiredoxin 2	Homo sapiens	41-45
31336342-5	2019	Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	191-215	NFE2 like bZIP transcription factor 2	Rattus norvegicus	23-57
31336342-5	2019	Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	191-215	NFE2 like bZIP transcription factor 2	Rattus norvegicus	59-63
31336342-5	2019	Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	217-221	NFE2 like bZIP transcription factor 2	Rattus norvegicus	23-57
31336342-5	2019	Once the expression of nuclear factor E2-related factor 2 (Nrf2) was silenced in H9C2 cells, aldehydes no longer produced enough antioxidant enzymes to reverse the oxidative damage caused by tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	217-221	NFE2 like bZIP transcription factor 2	Rattus norvegicus	59-63
31238070-5	2019	Here, the expression of SIRT2 was detected in AF cells exposed to tert-Butyl hydroperoxide (TBHP) by western blotting.	tert-Butylhydroperoxide	92-96	sirtuin 2	Sus scrofa	24-29
31238070-8	2019	The expression of SIRT2 was decreased in AF cells treated with TBHP.	tert-Butylhydroperoxide	63-67	sirtuin 2	Sus scrofa	18-23
31343889-2	2019	Normal alpha-functionalization of alpha-diazoketones was achieved via C(sp2)-H bond functionalization of aromatic amides in the presence of Co(acac)2/TBHP.	tert-Butylhydroperoxide	150-154	Sp2 transcription factor	Homo sapiens	70-75
31470549-2	2019	Using zebrafish (Danio rerio) as a model organism, the objective of the present study was to characterize the effects of waterborne exposure to both SeMet and tert-butyl hydroperoxide (tBOOH) to early life stages of zebrafish pre-treated with the antioxidant tert-butyl hydroquinone (tBHQ) in an attempt to investigate the mechanism of Se toxicity as it relates to oxidative stress.	tert-Butylhydroperoxide	185-190	telomerase reverse transcriptase	Danio rerio	159-163
31470549-2	2019	Using zebrafish (Danio rerio) as a model organism, the objective of the present study was to characterize the effects of waterborne exposure to both SeMet and tert-butyl hydroperoxide (tBOOH) to early life stages of zebrafish pre-treated with the antioxidant tert-butyl hydroquinone (tBHQ) in an attempt to investigate the mechanism of Se toxicity as it relates to oxidative stress.	tert-Butylhydroperoxide	185-190	telomerase reverse transcriptase	Danio rerio	259-263
31120192-7	2019	In short, our results suggested that the cardioprotective role of SDX was related to the suppression of ER stress in mice MI/R models and TBHP-induced H9C2 cell injury which was through the PI3K/Akt signalling pathway.	tert-Butylhydroperoxide	138-142	AKT serine/threonine kinase 1	Rattus norvegicus	195-198
31485293-8	2019	In both AMD and No AMD cells, NAC pretreatment reduced t-BHP-induced ROS production and protected from H2O2-induced cell death and ATP depletion.	tert-Butylhydroperoxide	55-60	X-linked Kx blood group	Homo sapiens	30-33
31406654-1	2019	P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert-butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min-1 and 196 min-1 respectively.	tert-Butylhydroperoxide	129-153	CD59 molecule (CD59 blood group)	Homo sapiens	208-213
31311168-7	2019	DW-CUR 20 inhibited the release of lactate dehydrogenase and decreased apoptosis-related proteins such as Poly (ADP-ribose) polymerase, cleaved caspase-7 and cleaved caspase-8 on t-BHP-treated HepG2 cells.	tert-Butylhydroperoxide	179-184	caspase 8	Homo sapiens	166-175
31406654-1	2019	P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert-butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min-1 and 196 min-1 respectively.	tert-Butylhydroperoxide	129-153	CD59 molecule (CD59 blood group)	Homo sapiens	222-227
31406654-1	2019	P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert-butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min-1 and 196 min-1 respectively.	tert-Butylhydroperoxide	155-159	CD59 molecule (CD59 blood group)	Homo sapiens	208-213
31406654-1	2019	P450 119 peroxygenase was found to catalyze the sulfoxidation of thioanisole and the sulfonation of sulfoxide in the presence of tert-butyl hydroperoxide (TBHP) for the first time with turnover rates of 1549 min-1 and 196 min-1 respectively.	tert-Butylhydroperoxide	155-159	CD59 molecule (CD59 blood group)	Homo sapiens	222-227
31131946-5	2019	Biochanin A (BCA), an O-methylated isoflavone with low direct antioxidant activity, can effectively protect HepG2 cells against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage via activation of the Nrf2 signaling, and thereby the induction of downstream cytoprotective enzymes including NAD(P)H quinone oxidoreductase-1, heme oxygenasae-1, and glutamate-cysteine ligase catalytic subunit.	tert-Butylhydroperoxide	128-152	B cell linker	Homo sapiens	0-11
31131946-5	2019	Biochanin A (BCA), an O-methylated isoflavone with low direct antioxidant activity, can effectively protect HepG2 cells against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage via activation of the Nrf2 signaling, and thereby the induction of downstream cytoprotective enzymes including NAD(P)H quinone oxidoreductase-1, heme oxygenasae-1, and glutamate-cysteine ligase catalytic subunit.	tert-Butylhydroperoxide	128-152	B cell linker	Homo sapiens	13-16
31131946-5	2019	Biochanin A (BCA), an O-methylated isoflavone with low direct antioxidant activity, can effectively protect HepG2 cells against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage via activation of the Nrf2 signaling, and thereby the induction of downstream cytoprotective enzymes including NAD(P)H quinone oxidoreductase-1, heme oxygenasae-1, and glutamate-cysteine ligase catalytic subunit.	tert-Butylhydroperoxide	154-159	B cell linker	Homo sapiens	0-11
31315737-11	2019	RESULTS: (1) The cell viability, the mRNA expression and the protein expression of SCAD were decreased gradually in a concentration and time dependent manner with the increase of tBHP concentration and the prolongation of intervention time.	tert-Butylhydroperoxide	179-183	acyl-CoA dehydrogenase short chain	Homo sapiens	83-87
31131946-5	2019	Biochanin A (BCA), an O-methylated isoflavone with low direct antioxidant activity, can effectively protect HepG2 cells against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage via activation of the Nrf2 signaling, and thereby the induction of downstream cytoprotective enzymes including NAD(P)H quinone oxidoreductase-1, heme oxygenasae-1, and glutamate-cysteine ligase catalytic subunit.	tert-Butylhydroperoxide	154-159	B cell linker	Homo sapiens	13-16
31221142-0	2019	ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress.	tert-Butylhydroperoxide	106-126	mitogen-activated protein kinase 1	Homo sapiens	0-3
31221142-0	2019	ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t-butylhydroperoxide-induced oxidative stress.	tert-Butylhydroperoxide	106-126	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
31006097-0	2019	Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway.	tert-Butylhydroperoxide	26-31	thymoma viral proto-oncogene 1	Mus musculus	107-110
31315737-15	2019	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as HUVEC treated with tBHP.	tert-Butylhydroperoxide	83-87	acyl-CoA dehydrogenase short chain	Homo sapiens	11-15
31013746-6	2019	In addition, acK685-STAT3 was found in response to IL-6, whereas glutC328/542-STAT3 and pS727-STAT3 occurred upon tert-butyl hydroperoxyde (tBHP) treatment.	tert-Butylhydroperoxide	140-144	signal transducer and activator of transcription 3	Homo sapiens	78-83
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	tert-Butylhydroperoxide	172-196	eukaryotic translation initiation factor 2A	Rattus norvegicus	91-100
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	tert-Butylhydroperoxide	172-196	DNA-damage inducible transcript 3	Rattus norvegicus	101-105
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	tert-Butylhydroperoxide	172-196	sirtuin 1	Rattus norvegicus	163-168
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	tert-Butylhydroperoxide	199-203	DNA-damage inducible transcript 3	Rattus norvegicus	101-105
31223428-9	2019	Taken together, our present findings firstly indicate that curcumin could inhibit the PERK-eIF2alpha-CHOP axis of the ER stress response through the activation of SIRT1 in tert-Butyl hydroperoxide- (TBHP-) treated rat chondrocytes and ameliorated osteoarthritis development in vivo.	tert-Butylhydroperoxide	199-203	sirtuin 1	Rattus norvegicus	163-168
31007025-7	2019	In fact, the Co(II) compounds act as heterogeneous catalysts for the oxidation of alcohols with tBuOOH ( tert-butylhydroperoxide) under mild conditions.	tert-Butylhydroperoxide	105-128	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19
30897380-8	2019	The cytoprotective property of Z-Lig was assessed in the tert-butyl hydroperoxide (t-BHP)-evoked oxidative stress model.	tert-Butylhydroperoxide	57-81	ubiquitin conjugating enzyme E2 K	Homo sapiens	33-36
30897380-8	2019	The cytoprotective property of Z-Lig was assessed in the tert-butyl hydroperoxide (t-BHP)-evoked oxidative stress model.	tert-Butylhydroperoxide	83-88	ubiquitin conjugating enzyme E2 K	Homo sapiens	33-36
30897380-12	2019	Furthermore, Z-Lig alleviated oxidative stress and cell injury caused by t-BHP via stimulation of the NRF2/ARE pathway.	tert-Butylhydroperoxide	73-78	ubiquitin conjugating enzyme E2 K	Homo sapiens	15-18
30897380-12	2019	Furthermore, Z-Lig alleviated oxidative stress and cell injury caused by t-BHP via stimulation of the NRF2/ARE pathway.	tert-Butylhydroperoxide	73-78	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
31013746-6	2019	In addition, acK685-STAT3 was found in response to IL-6, whereas glutC328/542-STAT3 and pS727-STAT3 occurred upon tert-butyl hydroperoxyde (tBHP) treatment.	tert-Butylhydroperoxide	140-144	signal transducer and activator of transcription 3	Homo sapiens	78-83
29653292-10	2019	The expression of JunB, JunD, P65 proteins all increased in tBHP-induced C28/I2 oxidative damage model compared with control group (P < 0.05) and decreased after Se supplementation.	tert-Butylhydroperoxide	60-64	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-22
30892359-3	2019	Notaly the reaction uses O2 as the terminal oxidant, instead of metal catalysts or oxidants like TBHP, leading to H2O and N2 as the clean by-products.	tert-Butylhydroperoxide	97-101	MT-RNR2 like 2 (pseudogene)	Homo sapiens	114-124
30658075-6	2019	SET protein knockdown (siSET) associated with tert-butyl hydroperoxide-induced oxidative stress sensitized Cal 27 and HN13 cells to apoptosis via the extrinsic and intrinsic pathways, respectively.	tert-Butylhydroperoxide	46-70	MT-RNR2 like 13 (pseudogene)	Homo sapiens	118-122
30807830-7	2019	RESULTS: Mn-TM-2-PyP protected HCE-T cells in a dose-dependent manner against tBHP-induced oxidative stress as determined by calculating the IC50 for tBHP in the resazurin, MTT and lactate dehydrogenase release cell viability assays.	tert-Butylhydroperoxide	78-82	RNA guanylyltransferase and 5'-phosphatase	Homo sapiens	31-34
29372310-12	2019	D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor.	tert-Butylhydroperoxide	31-36	thymoma viral proto-oncogene 1	Mus musculus	96-99
29372310-12	2019	D3R protective effects against t-BHP-induced osteoblastic dysfunction were mediated by the PI3K/Akt pathway since they were completely prevented by LY294002, a PI3K/Akt specific inhibitor.	tert-Butylhydroperoxide	31-36	thymoma viral proto-oncogene 1	Mus musculus	165-168
29653292-10	2019	The expression of JunB, JunD, P65 proteins all increased in tBHP-induced C28/I2 oxidative damage model compared with control group (P < 0.05) and decreased after Se supplementation.	tert-Butylhydroperoxide	60-64	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	24-28
30668448-0	2019	Rutin protects t-butyl hydroperoxide-induced oxidative impairment via modulating the Nrf2 and iNOS activity.	tert-Butylhydroperoxide	15-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	85-89
30668448-0	2019	Rutin protects t-butyl hydroperoxide-induced oxidative impairment via modulating the Nrf2 and iNOS activity.	tert-Butylhydroperoxide	15-36	nitric oxide synthase 2, inducible	Mus musculus	94-98
30668448-12	2019	Rutin also protected the erythrocytes against the t-BHP-induced oxidative stress as evidenced by augmented activity of antioxidant enzymes (CAT, SOD, GPX, GR and GST).	tert-Butylhydroperoxide	50-55	catalase	Mus musculus	140-143
30414849-7	2019	RESULTS: The nuclear localization of TFEB declined in degenerated rat NP tissue as well as in TBHP treated NP cells.	tert-Butylhydroperoxide	94-98	transcription factor EB	Rattus norvegicus	37-41
30277819-6	2019	We investigated the regulatory connection between NRF2 and AMPK during oxidative stress induced by tert-butyl hydroperoxide (TBHP) in HEK293T cells and C. elegans.	tert-Butylhydroperoxide	125-129	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	59-63
30277819-8	2019	After addition of TBHP, NRF2 and AMPK showed a quick activation; AMPK was later down-regulated, however, while NRF2 level remained high.	tert-Butylhydroperoxide	18-22	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
30277819-8	2019	After addition of TBHP, NRF2 and AMPK showed a quick activation; AMPK was later down-regulated, however, while NRF2 level remained high.	tert-Butylhydroperoxide	18-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	33-37
30277819-8	2019	After addition of TBHP, NRF2 and AMPK showed a quick activation; AMPK was later down-regulated, however, while NRF2 level remained high.	tert-Butylhydroperoxide	18-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	65-69
30277819-8	2019	After addition of TBHP, NRF2 and AMPK showed a quick activation; AMPK was later down-regulated, however, while NRF2 level remained high.	tert-Butylhydroperoxide	18-22	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
30277819-9	2019	Autophagosome formation and Unc-51-like autophagy activating kinase 1 phosphorylation were initially stimulated, but they returned to basal values after 4 h of TBHP treatment.	tert-Butylhydroperoxide	160-164	unc-51 like autophagy activating kinase 1	Homo sapiens	28-69
30779107-8	2019	Also, we found GES might rescue TBHP-induced NPCs degeneration by enhancing Nrf2-mediated antioxidant defense system.	tert-Butylhydroperoxide	32-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	76-80
30779107-9	2019	Silencing Nrf2 partly abolished the protective effects of GES on apoptosis and ECM disruption in TBHP-treated NPCs.	tert-Butylhydroperoxide	97-101	NFE2 like bZIP transcription factor 2	Rattus norvegicus	10-14
30277819-6	2019	We investigated the regulatory connection between NRF2 and AMPK during oxidative stress induced by tert-butyl hydroperoxide (TBHP) in HEK293T cells and C. elegans.	tert-Butylhydroperoxide	99-123	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
30277819-6	2019	We investigated the regulatory connection between NRF2 and AMPK during oxidative stress induced by tert-butyl hydroperoxide (TBHP) in HEK293T cells and C. elegans.	tert-Butylhydroperoxide	99-123	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	59-63
30277819-6	2019	We investigated the regulatory connection between NRF2 and AMPK during oxidative stress induced by tert-butyl hydroperoxide (TBHP) in HEK293T cells and C. elegans.	tert-Butylhydroperoxide	125-129	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
30414849-4	2019	METHODS: TFEB activity was detected in NP tissues in puncture-induced rat IVDD model by immunofluorescence as well as in tert-Butyl hydroperoxide (TBHP), the reactive oxygen species (ROS) donor to induce oxidative stress, treated NP cells by western blot.	tert-Butylhydroperoxide	121-145	transcription factor EB	Rattus norvegicus	9-13
30414849-4	2019	METHODS: TFEB activity was detected in NP tissues in puncture-induced rat IVDD model by immunofluorescence as well as in tert-Butyl hydroperoxide (TBHP), the reactive oxygen species (ROS) donor to induce oxidative stress, treated NP cells by western blot.	tert-Butylhydroperoxide	147-151	transcription factor EB	Rattus norvegicus	9-13
30414849-8	2019	Applying lentivirus to transfect NP cells, TFEB overexpression restored the TBHP-induced autophagic flux blockage and protected NP cells against apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition.	tert-Butylhydroperoxide	76-80	transcription factor EB	Rattus norvegicus	43-47
30414849-8	2019	Applying lentivirus to transfect NP cells, TFEB overexpression restored the TBHP-induced autophagic flux blockage and protected NP cells against apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition.	tert-Butylhydroperoxide	76-80	transcription factor EB	Rattus norvegicus	192-196
30414849-11	2019	TFEB overexpression suppressed TBHP-induced apoptosis and senescence via autophagic flux stimulation in NP cell and alleviates puncture-induced IVDD development in vivo.	tert-Butylhydroperoxide	31-35	transcription factor EB	Rattus norvegicus	0-4
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	72-95	heme oxygenase 1	Rattus norvegicus	25-29
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	72-95	ATP binding cassette subfamily B member 11	Rattus norvegicus	347-368
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	72-95	ATP binding cassette subfamily B member 11	Rattus norvegicus	370-374
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	72-95	ATP binding cassette subfamily C member 2	Rattus norvegicus	380-421
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	72-95	ATP binding cassette subfamily C member 2	Rattus norvegicus	423-427
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	97-103	heme oxygenase 1	Rattus norvegicus	25-29
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	97-103	ATP binding cassette subfamily B member 11	Rattus norvegicus	347-368
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	97-103	ATP binding cassette subfamily B member 11	Rattus norvegicus	370-374
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	97-103	ATP binding cassette subfamily C member 2	Rattus norvegicus	380-421
30538149-5	2019	During this time period, HO-1 induction fully prevented the pro-oxidant tert-butylhydroperoxide (tBuOOH)-induced drop in bile flow, and in the biliary excretion of bile salts and glutathione, the two main driving forces of bile flow; this was associated with preservation of the membrane localization of their respective canalicular transporters, bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2), which are otherwise endocytosed by OS.	tert-Butylhydroperoxide	97-103	ATP binding cassette subfamily C member 2	Rattus norvegicus	423-427
30538149-6	2019	HO-1 induction counteracted the oxidation of intracellular proteins and membrane lipids induced by tBuOOH, and fully prevented the increase in the oxidized-to-total glutathione (GSHt) ratio, a sensitive parameter of hepatocellular OS.	tert-Butylhydroperoxide	99-105	heme oxygenase 1	Rattus norvegicus	0-4
30376995-3	2018	In this study, we show that cold-sensitive receptor TRPM8 is activated by pro-oxidant tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	86-110	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	52-57
30272282-0	2018	Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway.	tert-Butylhydroperoxide	67-91	NFE2 like bZIP transcription factor 2	Homo sapiens	140-144
30031690-5	2018	In AEC, the treatment of tert-butylhydroperoxide, a pro-oxidant that triggers transient pore opening in high conductance in AEM, induces yeast death, which is also dependent on CsA and Cpr3.	tert-Butylhydroperoxide	25-48	peptidylprolyl isomerase CPR3	Saccharomyces cerevisiae S288C	185-189
30273691-8	2018	In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes.	tert-Butylhydroperoxide	3-27	brain protein 1	Mus musculus	62-65
30273691-8	2018	In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes.	tert-Butylhydroperoxide	3-27	NFE2 like bZIP transcription factor 2	Homo sapiens	132-175
30273691-8	2018	In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes.	tert-Butylhydroperoxide	3-27	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
30273691-8	2018	In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes.	tert-Butylhydroperoxide	29-34	brain protein 1	Mus musculus	62-65
30273691-8	2018	In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes.	tert-Butylhydroperoxide	29-34	NFE2 like bZIP transcription factor 2	Homo sapiens	132-175
30273691-8	2018	In tert-butyl hydroperoxide (t-BHP)-treated HepG2 cells, CORM A-1 augmented cell viability, reduced oxidative stress, activated the nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant response element (ARE) genes.	tert-Butylhydroperoxide	29-34	NFE2 like bZIP transcription factor 2	Homo sapiens	177-181
30376995-5	2018	WS-12, a selective TRPM8 channel agonist, and tBHP increased intracellular Ca2+ concentration in differentiated PC12 cells; an effect attenuated by AMTB, a selective TRPM8 channel blocker, and siRNA-mediated TRPM8 knockdown.	tert-Butylhydroperoxide	46-50	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	166-171
30376995-5	2018	WS-12, a selective TRPM8 channel agonist, and tBHP increased intracellular Ca2+ concentration in differentiated PC12 cells; an effect attenuated by AMTB, a selective TRPM8 channel blocker, and siRNA-mediated TRPM8 knockdown.	tert-Butylhydroperoxide	46-50	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	166-171
30376995-6	2018	Blockade of TRPM8 channels also reduced WS-12- and tBHP-evoked norepinephrine secretion from the cells.	tert-Butylhydroperoxide	51-55	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	12-17
30376995-3	2018	In this study, we show that cold-sensitive receptor TRPM8 is activated by pro-oxidant tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	112-116	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	52-57
30209478-1	2018	A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP was developed.	tert-Butylhydroperoxide	175-179	complement C4A (Rodgers blood group)	Homo sapiens	46-49
30538798-8	2018	Further studies have shown that HCEA inhibits t-BHP-induced apoptosis by increasing B-cell lymphoma-2 (BCL-2) activity and decreasing caspase-3 and caspase-9 activity.	tert-Butylhydroperoxide	46-51	BCL2, apoptosis regulator	Rattus norvegicus	84-101
30538798-8	2018	Further studies have shown that HCEA inhibits t-BHP-induced apoptosis by increasing B-cell lymphoma-2 (BCL-2) activity and decreasing caspase-3 and caspase-9 activity.	tert-Butylhydroperoxide	46-51	BCL2, apoptosis regulator	Rattus norvegicus	103-108
30538798-8	2018	Further studies have shown that HCEA inhibits t-BHP-induced apoptosis by increasing B-cell lymphoma-2 (BCL-2) activity and decreasing caspase-3 and caspase-9 activity.	tert-Butylhydroperoxide	46-51	caspase 3	Rattus norvegicus	134-143
30538798-8	2018	Further studies have shown that HCEA inhibits t-BHP-induced apoptosis by increasing B-cell lymphoma-2 (BCL-2) activity and decreasing caspase-3 and caspase-9 activity.	tert-Butylhydroperoxide	46-51	caspase 9	Rattus norvegicus	148-157
30106090-13	2018	In conclusion, the present study suggested that the activated TREK-TRAAK K2P channels serve a role in protecting hRPE cells against the oxidative stress induced by t-BH, which indicated that these K2P channels are potential novel targets in retinal protection and provided a new direction for research and therapy in retinal degeneration diseases.	tert-Butylhydroperoxide	164-168	potassium two pore domain channel subfamily K member 2	Homo sapiens	62-66
30106090-13	2018	In conclusion, the present study suggested that the activated TREK-TRAAK K2P channels serve a role in protecting hRPE cells against the oxidative stress induced by t-BH, which indicated that these K2P channels are potential novel targets in retinal protection and provided a new direction for research and therapy in retinal degeneration diseases.	tert-Butylhydroperoxide	164-168	potassium two pore domain channel subfamily K member 4	Homo sapiens	67-72
30349447-9	2018	Afterward, a PI3K inhibitor, LY294002, was applied to confirm the influence of the PI3K/Akt pathway on TBHP-treated cells of 3,5-diCQA.	tert-Butylhydroperoxide	103-107	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
30074270-2	2018	This study examined mitochondrial targets of active PKCepsilon in RPTC injured by the model oxidant tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	100-124	protein kinase C epsilon	Homo sapiens	52-62
30074270-2	2018	This study examined mitochondrial targets of active PKCepsilon in RPTC injured by the model oxidant tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	126-130	protein kinase C epsilon	Homo sapiens	52-62
30074270-3	2018	TBHP exposure augmented the levels of phosphorylated (active) PKCepsilon in mitochondria, which suggested translocation of PKCepsilon to mitochondria after oxidant exposure.	tert-Butylhydroperoxide	0-4	protein kinase C epsilon	Homo sapiens	62-72
30074270-3	2018	TBHP exposure augmented the levels of phosphorylated (active) PKCepsilon in mitochondria, which suggested translocation of PKCepsilon to mitochondria after oxidant exposure.	tert-Butylhydroperoxide	0-4	protein kinase C epsilon	Homo sapiens	123-133
30349447-12	2018	Moreover, 3,5-diCQA decreased expressions of Bax and caspase-3 but increased the phosphorylation levels of PI3K and Akt in TBHP-treated cells, which are the key molecules mediating cell survival, whereas phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphorylation was unchanged.	tert-Butylhydroperoxide	123-127	AKT serine/threonine kinase 1	Rattus norvegicus	116-119
30349447-12	2018	Moreover, 3,5-diCQA decreased expressions of Bax and caspase-3 but increased the phosphorylation levels of PI3K and Akt in TBHP-treated cells, which are the key molecules mediating cell survival, whereas phosphatase and tensin homologue deleted on chromosome 10 (PTEN) phosphorylation was unchanged.	tert-Butylhydroperoxide	123-127	phosphatase and tensin homolog	Rattus norvegicus	263-267
30956868-1	2019	against t-BHP-induced oxidative stress by modulations of Nrf2 and its related enzymes in HepG2 cells.	tert-Butylhydroperoxide	8-13	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
30956868-4	2019	The treatment with chebulic acid attenuated cell death in t-BHP-induced HepG2 liver cells and increased intracellular glutathione content, upregulated the activity of heme oxygenase-1, and also increased the translocation of Nrf2 into the nucleus and Nrf2 target gene expression in a dose-dependent manner.	tert-Butylhydroperoxide	58-63	NFE2 like bZIP transcription factor 2	Homo sapiens	225-229
30956868-6	2019	The overall result is that chebulic acid has cytoprotective effect on t-BHP-induced hepatotoxicity in HepG2 cells through Nrf2-mediated antioxidant enzymes.	tert-Butylhydroperoxide	70-75	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
29066411-0	2018	Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response.	tert-Butylhydroperoxide	52-76	mitogen-activated protein kinase 1	Homo sapiens	115-118
30542607-4	2018	TBH (500 muM; 24 h) increased uptake of both low (SGLT1-mediated) and high concentrations (SGLT1- and GLUT2-mediated) of 3H-DG, but did not affect absorption of 14C-fructose (GLUT2- and GLUT5-mediated).	tert-Butylhydroperoxide	0-3	solute carrier family 5 member 1	Homo sapiens	50-55
30542607-4	2018	TBH (500 muM; 24 h) increased uptake of both low (SGLT1-mediated) and high concentrations (SGLT1- and GLUT2-mediated) of 3H-DG, but did not affect absorption of 14C-fructose (GLUT2- and GLUT5-mediated).	tert-Butylhydroperoxide	0-3	solute carrier family 5 member 1	Homo sapiens	91-96
30542607-4	2018	TBH (500 muM; 24 h) increased uptake of both low (SGLT1-mediated) and high concentrations (SGLT1- and GLUT2-mediated) of 3H-DG, but did not affect absorption of 14C-fructose (GLUT2- and GLUT5-mediated).	tert-Butylhydroperoxide	0-3	solute carrier family 2 member 2	Homo sapiens	102-107
30542607-4	2018	TBH (500 muM; 24 h) increased uptake of both low (SGLT1-mediated) and high concentrations (SGLT1- and GLUT2-mediated) of 3H-DG, but did not affect absorption of 14C-fructose (GLUT2- and GLUT5-mediated).	tert-Butylhydroperoxide	0-3	solute carrier family 2 member 2	Homo sapiens	175-180
30542607-4	2018	TBH (500 muM; 24 h) increased uptake of both low (SGLT1-mediated) and high concentrations (SGLT1- and GLUT2-mediated) of 3H-DG, but did not affect absorption of 14C-fructose (GLUT2- and GLUT5-mediated).	tert-Butylhydroperoxide	0-3	solute carrier family 2 member 5	Homo sapiens	186-191
29066411-8	2018	Collectively, GA effectively protects against t-BHP-induced hepatotoxicity via inducing ERK/Nrf2-mediated antioxidative signaling pathway.	tert-Butylhydroperoxide	46-51	mitogen-activated protein kinase 1	Homo sapiens	88-91
29066411-8	2018	Collectively, GA effectively protects against t-BHP-induced hepatotoxicity via inducing ERK/Nrf2-mediated antioxidative signaling pathway.	tert-Butylhydroperoxide	46-51	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
29066411-0	2018	Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response.	tert-Butylhydroperoxide	52-76	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
29066411-0	2018	Gallic acid, a natural polyphenol, protects against tert-butyl hydroperoxide- induced hepatotoxicity by activating ERK-Nrf2-Keap1-mediated antioxidative response.	tert-Butylhydroperoxide	52-76	kelch like ECH associated protein 1	Homo sapiens	124-129
29066411-2	2018	We herein investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response in the protection of GA against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in L02 cells.	tert-Butylhydroperoxide	157-181	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
29066411-2	2018	We herein investigated the critical role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated antioxidant response in the protection of GA against tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in L02 cells.	tert-Butylhydroperoxide	183-188	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
29572097-11	2018	Short-term TBHP treatment induced a gradual decrease in APP but an increase in Abeta levels over time.	tert-Butylhydroperoxide	11-15	amyloid beta precursor protein	Homo sapiens	79-84
29909290-3	2018	REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes  H2O2 also elevated REDD1 mRNA levels.	tert-Butylhydroperoxide	39-62	DNA damage inducible transcript 4	Homo sapiens	0-5
29909290-3	2018	REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes  H2O2 also elevated REDD1 mRNA levels.	tert-Butylhydroperoxide	39-62	DNA damage inducible transcript 4	Homo sapiens	111-116
29909290-3	2018	REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes  H2O2 also elevated REDD1 mRNA levels.	tert-Butylhydroperoxide	64-69	DNA damage inducible transcript 4	Homo sapiens	0-5
29909290-3	2018	REDD1 protein was increased in H2O2 or tert-butylhydroperoxide (t-BHP)-treated hepatocytes  H2O2 also elevated REDD1 mRNA levels.	tert-Butylhydroperoxide	64-69	DNA damage inducible transcript 4	Homo sapiens	111-116
29909290-8	2018	Furthermore, we observed that REDD1 overexpression attenuated H2O2 or t-BHP-derived reactive oxygen species formation as well as cytotoxicity.	tert-Butylhydroperoxide	70-75	DNA damage inducible transcript 4	Homo sapiens	30-35
29909290-9	2018	Conversely, siRNA against REDD1 aggravated t-BHP-induced reactive oxygen species generation and cell death.	tert-Butylhydroperoxide	43-48	DNA damage inducible transcript 4	Homo sapiens	26-31
29380194-6	2018	Pretreatment with morphine augmented p38 phosphorylation, and the increased phospho-p38/p38 ratio was preserved even in the presence of t-BHP.	tert-Butylhydroperoxide	136-141	mitogen activated protein kinase 14	Rattus norvegicus	84-87
29380194-6	2018	Pretreatment with morphine augmented p38 phosphorylation, and the increased phospho-p38/p38 ratio was preserved even in the presence of t-BHP.	tert-Butylhydroperoxide	136-141	mitogen activated protein kinase 14	Rattus norvegicus	84-87
29380194-7	2018	Morphine did not change the level of GSK-3beta phosphorylation, but interestingly, the phospho-GSK-3beta/GSK-3beta ratio significantly increased after subsequent incubation with t-BHP.	tert-Butylhydroperoxide	178-183	glycogen synthase kinase 3 beta	Rattus norvegicus	95-104
29380194-7	2018	Morphine did not change the level of GSK-3beta phosphorylation, but interestingly, the phospho-GSK-3beta/GSK-3beta ratio significantly increased after subsequent incubation with t-BHP.	tert-Butylhydroperoxide	178-183	glycogen synthase kinase 3 beta	Rattus norvegicus	95-104
29871486-0	2018	Attenuation of tert-Butyl Hydroperoxide ( t-BHP)-Induced Oxidative Damage in HepG2 Cells by Tangeretin: Relevance of the Nrf2-ARE and MAPK Signaling Pathways.	tert-Butylhydroperoxide	42-47	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	tert-Butylhydroperoxide	81-86	mitogen-activated protein kinase 1	Homo sapiens	272-275
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	tert-Butylhydroperoxide	81-86	mitogen-activated protein kinase 1	Homo sapiens	276-280
29655054-9	2018	Oregonin prevented the t-BH-induced increase in monolayer permeability through inhibition of the reduction in expression of zonula occludens-1 and occludin in Caco-2 cells.	tert-Butylhydroperoxide	23-27	occludin	Homo sapiens	147-155
30154423-4	2018	We demonstrated that the expression and nuclear localization of TFEB is decreased in human and mouse OA cartilage as well as in tert-Butyl hydroperoxide (TBHP)-treated chondrocytes.	tert-Butylhydroperoxide	128-152	transcription factor EB	Homo sapiens	64-68
30154423-4	2018	We demonstrated that the expression and nuclear localization of TFEB is decreased in human and mouse OA cartilage as well as in tert-Butyl hydroperoxide (TBHP)-treated chondrocytes.	tert-Butylhydroperoxide	154-158	transcription factor EB	Homo sapiens	64-68
30154423-5	2018	Applying lentivirus to transfect chondrocytes, we found that TFEB overexpression rescues the TBHP-induced the autophagic flux damage, lysosome dysfunction and protects chondrocyte against TBHP induced apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition.	tert-Butylhydroperoxide	93-97	transcription factor EB	Mus musculus	61-65
30154423-5	2018	Applying lentivirus to transfect chondrocytes, we found that TFEB overexpression rescues the TBHP-induced the autophagic flux damage, lysosome dysfunction and protects chondrocyte against TBHP induced apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition.	tert-Butylhydroperoxide	93-97	transcription factor EB	Mus musculus	248-252
30154423-5	2018	Applying lentivirus to transfect chondrocytes, we found that TFEB overexpression rescues the TBHP-induced the autophagic flux damage, lysosome dysfunction and protects chondrocyte against TBHP induced apoptosis and senescence; these protections of TFEB are diminished by chloroquine-medicated autophagy inhibition.	tert-Butylhydroperoxide	188-192	transcription factor EB	Mus musculus	61-65
29932202-6	2018	Even at the lowest concentrations (50 mug mL-1), the extract was efficiently able to protect human cells against t-BHP-induced oxidative damage.	tert-Butylhydroperoxide	113-118	L1 cell adhesion molecule	Mus musculus	42-46
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	tert-Butylhydroperoxide	81-86	NFE2 like bZIP transcription factor 2	Homo sapiens	230-234
29804278-8	2018	The protective effects of the anthraquinone and naphthopyrone glycosides against t-BHP-induced oxidative damage in human liver-derived HepG2 cells were due to the prevention of ROS generation and up-regulated activity of HO-1 via Nrf2 activation and modulation of the JNK/ERK/MAPK signaling pathway.	tert-Butylhydroperoxide	81-86	mitogen-activated protein kinase 8	Homo sapiens	268-271
29410501-6	2018	Furthermore, Schwann cells in culture pretreated with LXR agonist, TO901317, exhibit improved defenses against oxidative stress generated by tert-butyl hydroperoxide, implying that LXRs play an important role in maintaining the redox homeostasis in the peripheral nervous system.	tert-Butylhydroperoxide	141-165	nuclear receptor subfamily 1, group H, member 2	Mus musculus	54-57
29549414-5	2018	The results of the comet assay demonstrated comparable sensitivity of hASC and hDHP to detect DNA damage induced by a direct acting genotoxic agent tert-butylhydroperoxide.	tert-Butylhydroperoxide	148-171	dihydropyrimidinase	Homo sapiens	79-83
29080823-10	2018	Depending on the incubation regimen, quercetin-biapigenin PCL-loaded nanoparticles or free compounds were more effective in protecting HepG2 cells against tert-butylhydroperoxide-induced toxicity.	tert-Butylhydroperoxide	155-178	PHD finger protein 1	Homo sapiens	58-61
29079702-6	2018	Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2.	tert-Butylhydroperoxide	23-47	thymoma viral proto-oncogene 2	Mus musculus	82-86
29079702-6	2018	Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2.	tert-Butylhydroperoxide	23-47	thymoma viral proto-oncogene 2	Mus musculus	173-177
29079702-6	2018	Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2.	tert-Butylhydroperoxide	49-53	thymoma viral proto-oncogene 2	Mus musculus	82-86
29079702-6	2018	Moreover, MT prevented tert-butyl hydroperoxide (tBHP)-reduced insulin-stimulated Akt2 phosphorylation in MT-TG cardiomyocytes, which was abolished by specific silencing of Akt2.	tert-Butylhydroperoxide	49-53	thymoma viral proto-oncogene 2	Mus musculus	173-177
29079702-7	2018	Specific silencing of TRB3 blocked tBHP inhibition of insulin-stimulated Akt2 phosphorylation in WT cardiomyocytes, whereas overexpression of TRB3 in MT-TG cardiomyocytes and hearts abolished MT preservation of insulin-stimulated Akt2 signals and MT prevention of DCM.	tert-Butylhydroperoxide	35-39	tribbles pseudokinase 3	Mus musculus	22-26
29079702-7	2018	Specific silencing of TRB3 blocked tBHP inhibition of insulin-stimulated Akt2 phosphorylation in WT cardiomyocytes, whereas overexpression of TRB3 in MT-TG cardiomyocytes and hearts abolished MT preservation of insulin-stimulated Akt2 signals and MT prevention of DCM.	tert-Butylhydroperoxide	35-39	thymoma viral proto-oncogene 2	Mus musculus	73-77
29371164-5	2018	Thus, Avns reduced IKKbeta kinase activity in response to tert-butyl hydroperoxide (tBHP) stimulation and attenuated tBHP-induced TNFalpha and IL-1beta mRNA expression.	tert-Butylhydroperoxide	58-82	inhibitor of kappaB kinase beta	Mus musculus	19-26
29371164-5	2018	Thus, Avns reduced IKKbeta kinase activity in response to tert-butyl hydroperoxide (tBHP) stimulation and attenuated tBHP-induced TNFalpha and IL-1beta mRNA expression.	tert-Butylhydroperoxide	84-88	inhibitor of kappaB kinase beta	Mus musculus	19-26
29371164-5	2018	Thus, Avns reduced IKKbeta kinase activity in response to tert-butyl hydroperoxide (tBHP) stimulation and attenuated tBHP-induced TNFalpha and IL-1beta mRNA expression.	tert-Butylhydroperoxide	117-121	tumor necrosis factor	Mus musculus	130-138
29371164-5	2018	Thus, Avns reduced IKKbeta kinase activity in response to tert-butyl hydroperoxide (tBHP) stimulation and attenuated tBHP-induced TNFalpha and IL-1beta mRNA expression.	tert-Butylhydroperoxide	117-121	interleukin 1 beta	Mus musculus	143-151
29371164-6	2018	Furthermore, the three-fold increases in cyclooxygenase-2 (COX-2) protein and luciferase activity with tBHP treatment were reduced by 50% with Avns (P < .01), along with decreased prostaglandin E2 levels (P < .01).	tert-Butylhydroperoxide	103-107	prostaglandin-endoperoxide synthase 2	Mus musculus	41-57
29371164-6	2018	Furthermore, the three-fold increases in cyclooxygenase-2 (COX-2) protein and luciferase activity with tBHP treatment were reduced by 50% with Avns (P < .01), along with decreased prostaglandin E2 levels (P < .01).	tert-Butylhydroperoxide	103-107	prostaglandin-endoperoxide synthase 2	Mus musculus	59-64
29606760-4	2018	Quercetin improved the stress resistance of tel1  cells when challenged with oxidants such as hydrogen peroxide (H2O2), menadine bisulphite (MBS) and tertiary butyl hydroperoxide (t-BHP) by scavenging reactive oxygen species (ROS).	tert-Butylhydroperoxide	180-185	DNA-binding protein kinase TEL1	Saccharomyces cerevisiae S288C	44-48
29425713-4	2018	Considering that preeclampsia is associated with increased placental oxidative stress levels, we investigated the effect of oxidative stress induced by tert-butylhydroperoxide (TBH) in human trophoblast-derived cells cultured upon deficient/low, physiological and supra-physiological folic acid levels.	tert-Butylhydroperoxide	177-180	telomerase reverse transcriptase	Homo sapiens	152-156
29134661-10	2018	Connversely, activation of PLA2 or application of active PLA2 , as well as lipid peroxidation induced by reactive oxygen species (ROS) using staurosporine or tert-butyl hydroperoxide, enhanced ion currents by TMEM16A/F and in addition activated phospholipid scrambling by TMEM16F.	tert-Butylhydroperoxide	158-182	anoctamin 1	Homo sapiens	209-216
29253822-7	2018	Cell aggregation as well as the down-regulation of IL-1beta, TNFalpha and PGE2 caused by the culture on collagen I-coated surface were suppressed by ROS donor, tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	160-183	interleukin 1 beta	Homo sapiens	51-59
29253822-7	2018	Cell aggregation as well as the down-regulation of IL-1beta, TNFalpha and PGE2 caused by the culture on collagen I-coated surface were suppressed by ROS donor, tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	160-183	tumor necrosis factor	Homo sapiens	61-69
29253822-7	2018	Cell aggregation as well as the down-regulation of IL-1beta, TNFalpha and PGE2 caused by the culture on collagen I-coated surface were suppressed by ROS donor, tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	185-189	interleukin 1 beta	Homo sapiens	51-59
29253822-7	2018	Cell aggregation as well as the down-regulation of IL-1beta, TNFalpha and PGE2 caused by the culture on collagen I-coated surface were suppressed by ROS donor, tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	185-189	tumor necrosis factor	Homo sapiens	61-69
29518773-3	2018	Increased intracellular tert-butylhydroperoxide (t-BHP) may be critical for oxidant toxicity, and is commonly used for evaluating mechanisms involving oxidative stress, but the method remains controversial.	tert-Butylhydroperoxide	49-54	telomerase reverse transcriptase	Mus musculus	24-28
29330409-10	2018	JNK1/2 and ERK1/2 played important roles in t-BHP-induced cell death.	tert-Butylhydroperoxide	44-49	mitogen activated protein kinase 3	Rattus norvegicus	11-17
29128606-6	2018	Further biomedical research indicated that SAAS pretreatment reduced the t-BHP induced increase of lactate dehydrogenase (LDH), intracellular reactive oxygen species (ROS), malondialdehyde (MDA) and mitochondrial membrane potential (MMP), and the decrease of key antioxidant enzymes through mitochondria antioxidative pathways via JAK2/STAT3 and PI3K/Akt/GSK-3beta signalings.	tert-Butylhydroperoxide	73-78	Janus kinase 2	Homo sapiens	331-335
29128606-6	2018	Further biomedical research indicated that SAAS pretreatment reduced the t-BHP induced increase of lactate dehydrogenase (LDH), intracellular reactive oxygen species (ROS), malondialdehyde (MDA) and mitochondrial membrane potential (MMP), and the decrease of key antioxidant enzymes through mitochondria antioxidative pathways via JAK2/STAT3 and PI3K/Akt/GSK-3beta signalings.	tert-Butylhydroperoxide	73-78	signal transducer and activator of transcription 3	Homo sapiens	336-341
29128606-6	2018	Further biomedical research indicated that SAAS pretreatment reduced the t-BHP induced increase of lactate dehydrogenase (LDH), intracellular reactive oxygen species (ROS), malondialdehyde (MDA) and mitochondrial membrane potential (MMP), and the decrease of key antioxidant enzymes through mitochondria antioxidative pathways via JAK2/STAT3 and PI3K/Akt/GSK-3beta signalings.	tert-Butylhydroperoxide	73-78	AKT serine/threonine kinase 1	Homo sapiens	351-354
29128606-6	2018	Further biomedical research indicated that SAAS pretreatment reduced the t-BHP induced increase of lactate dehydrogenase (LDH), intracellular reactive oxygen species (ROS), malondialdehyde (MDA) and mitochondrial membrane potential (MMP), and the decrease of key antioxidant enzymes through mitochondria antioxidative pathways via JAK2/STAT3 and PI3K/Akt/GSK-3beta signalings.	tert-Butylhydroperoxide	73-78	glycogen synthase kinase 3 beta	Homo sapiens	355-364
29518773-11	2018	Furthermore, t-BHP induced liver FL83B cell viability and apoptosis by upregulating the levels of PDIA6; this process could be involved in the activation of the IRE1alpha/ASK1/JNK1/2/p38 signalling pathways.	tert-Butylhydroperoxide	13-18	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	161-170
29111459-7	2018	Our studies show that pharmacological inhibition of MD2 prevented TBHP-induced reactive oxygen species (ROS) generation, inflammation and subsequent apoptosis in Muller cells.	tert-Butylhydroperoxide	66-70	lymphocyte antigen 96	Mus musculus	52-55
29518773-6	2018	A proteomic assay provided information that was used to identify the differentially expressed proteins following t-BHP treatment; immunohistochemistry and western blotting were performed to detect the expression of PDIA6 activity in apoptotic and endoplasmic reticulum (ER) stress pathways.	tert-Butylhydroperoxide	113-118	protein disulfide isomerase associated 6	Mus musculus	215-220
29518773-11	2018	Furthermore, t-BHP induced liver FL83B cell viability and apoptosis by upregulating the levels of PDIA6; this process could be involved in the activation of the IRE1alpha/ASK1/JNK1/2/p38 signalling pathways.	tert-Butylhydroperoxide	13-18	mitogen-activated protein kinase kinase kinase 5	Mus musculus	171-175
29518773-11	2018	Furthermore, t-BHP induced liver FL83B cell viability and apoptosis by upregulating the levels of PDIA6; this process could be involved in the activation of the IRE1alpha/ASK1/JNK1/2/p38 signalling pathways.	tert-Butylhydroperoxide	13-18	mitogen-activated protein kinase 8	Mus musculus	176-182
29518773-8	2018	This treatment also increased the level of PDIA6; this was validated in vitro and in vivo based on a comparison of t-BHP-treated and -untreated groups.	tert-Butylhydroperoxide	115-120	protein disulfide isomerase associated 6	Mus musculus	43-48
29518773-11	2018	Furthermore, t-BHP induced liver FL83B cell viability and apoptosis by upregulating the levels of PDIA6; this process could be involved in the activation of the IRE1alpha/ASK1/JNK1/2/p38 signalling pathways.	tert-Butylhydroperoxide	13-18	mitogen-activated protein kinase 14	Mus musculus	183-186
29518773-10	2018	t-BHP-dependent induction of apoptosis was accompanied by sustained phosphorylation of the IRE1alpha/ASK1/JNK1/2/p38 pathways and PDIA6 expression.	tert-Butylhydroperoxide	0-5	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	91-100
29518773-12	2018	CONCLUSIONS: We conclude that t-BHP induced an apoptosis cascade and ER stress in hepatocytes by upregulation of PDIA6, providing a new mechanism underlying the effects of t-BHP on liver injury.	tert-Butylhydroperoxide	30-35	protein disulfide isomerase associated 6	Mus musculus	113-118
29518773-12	2018	CONCLUSIONS: We conclude that t-BHP induced an apoptosis cascade and ER stress in hepatocytes by upregulation of PDIA6, providing a new mechanism underlying the effects of t-BHP on liver injury.	tert-Butylhydroperoxide	172-177	protein disulfide isomerase associated 6	Mus musculus	113-118
29518773-10	2018	t-BHP-dependent induction of apoptosis was accompanied by sustained phosphorylation of the IRE1alpha/ASK1/JNK1/2/p38 pathways and PDIA6 expression.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase kinase kinase 5	Mus musculus	101-105
29518773-10	2018	t-BHP-dependent induction of apoptosis was accompanied by sustained phosphorylation of the IRE1alpha/ASK1/JNK1/2/p38 pathways and PDIA6 expression.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase 8	Mus musculus	106-112
29518773-10	2018	t-BHP-dependent induction of apoptosis was accompanied by sustained phosphorylation of the IRE1alpha/ASK1/JNK1/2/p38 pathways and PDIA6 expression.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase 14	Mus musculus	113-116
29518773-10	2018	t-BHP-dependent induction of apoptosis was accompanied by sustained phosphorylation of the IRE1alpha/ASK1/JNK1/2/p38 pathways and PDIA6 expression.	tert-Butylhydroperoxide	0-5	protein disulfide isomerase associated 6	Mus musculus	130-135
29518773-11	2018	Furthermore, t-BHP induced liver FL83B cell viability and apoptosis by upregulating the levels of PDIA6; this process could be involved in the activation of the IRE1alpha/ASK1/JNK1/2/p38 signalling pathways.	tert-Butylhydroperoxide	13-18	protein disulfide isomerase associated 6	Mus musculus	98-103
29166025-1	2017	Copper(II)-catalyzed cross-coupling of anilines, methyl arenes, and TMSN3 in the presence of tert-butylhydroperoxide at moderate temperature produced 2-aryl benzimidazoles via a tandem C(sp3/sp2)-H functionalization and C-N bond formations.	tert-Butylhydroperoxide	93-116	Sp2 transcription factor	Homo sapiens	191-194
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	15-36	amyloid beta precursor protein	Homo sapiens	114-119
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	15-36	protein kinase C epsilon	Homo sapiens	140-144
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	15-36	superoxide dismutase 2	Homo sapiens	146-151
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	15-36	brain derived neurotrophic factor	Homo sapiens	153-157
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	38-42	amyloid beta precursor protein	Homo sapiens	114-119
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	38-42	protein kinase C epsilon	Homo sapiens	140-144
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	38-42	superoxide dismutase 2	Homo sapiens	146-151
29710707-6	2018	Treatment with t-butyl hydroperoxide (TBHP) increased superoxide, the oxidative DNA/RNA damage marker, 8-OHG, and Abeta levels, but reduced PKCe, MnSOD, BDNF, and cultured neuron density.	tert-Butylhydroperoxide	38-42	brain derived neurotrophic factor	Homo sapiens	153-157
29630935-7	2018	The most sensitive and reliable combination for this ROS assay was 10 muM DCFDA with 25 muM TBHP; since higher concentrations of DCFDA compromised cell viability.	tert-Butylhydroperoxide	92-96	latexin	Homo sapiens	70-73
29630935-7	2018	The most sensitive and reliable combination for this ROS assay was 10 muM DCFDA with 25 muM TBHP; since higher concentrations of DCFDA compromised cell viability.	tert-Butylhydroperoxide	92-96	latexin	Homo sapiens	88-91
29169345-7	2017	In addition, the cells in the cotreated group had a higher effect on increasing the expression of TRAAK than the t-BHP group.	tert-Butylhydroperoxide	113-118	potassium two pore domain channel subfamily K member 4	Homo sapiens	98-103
29242562-4	2017	Treatment of HCT116 cells with the oxidant tert-butyl hydroperoxide (tBHP) induced apoptosis and reduced NHLRC2 protein levels, whereas pretreatment with the antioxidant N-acetyl-L-cysteine prevented apoptosis and the decrease in NHLRC2 protein levels seen in tBHP-treated cells.	tert-Butylhydroperoxide	43-67	NHL repeat containing 2	Homo sapiens	105-111
29242562-4	2017	Treatment of HCT116 cells with the oxidant tert-butyl hydroperoxide (tBHP) induced apoptosis and reduced NHLRC2 protein levels, whereas pretreatment with the antioxidant N-acetyl-L-cysteine prevented apoptosis and the decrease in NHLRC2 protein levels seen in tBHP-treated cells.	tert-Butylhydroperoxide	43-67	NHL repeat containing 2	Homo sapiens	230-236
29242562-4	2017	Treatment of HCT116 cells with the oxidant tert-butyl hydroperoxide (tBHP) induced apoptosis and reduced NHLRC2 protein levels, whereas pretreatment with the antioxidant N-acetyl-L-cysteine prevented apoptosis and the decrease in NHLRC2 protein levels seen in tBHP-treated cells.	tert-Butylhydroperoxide	69-73	NHL repeat containing 2	Homo sapiens	105-111
29242562-4	2017	Treatment of HCT116 cells with the oxidant tert-butyl hydroperoxide (tBHP) induced apoptosis and reduced NHLRC2 protein levels, whereas pretreatment with the antioxidant N-acetyl-L-cysteine prevented apoptosis and the decrease in NHLRC2 protein levels seen in tBHP-treated cells.	tert-Butylhydroperoxide	69-73	NHL repeat containing 2	Homo sapiens	230-236
28401421-5	2017	To monitor tert-butyl hydroperoxide-induced oxidative changes of DMa and BMs, electron paramagnetic resonance spectroscopy, UV-vis absorption spectroscopy, dynamic light scattering, atomic force microscopy and electron paramagnetic resonance oximetry were employed.	tert-Butylhydroperoxide	11-35	major histocompatibility complex, class II, DM alpha	Homo sapiens	65-68
29216242-0	2017	The OxyR-regulated phnW gene encoding 2-aminoethylphosphonate:pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert-butyl hydroperoxide.	tert-Butylhydroperoxide	130-154	transcriptional regulator	Pseudomonas aeruginosa PAO1	4-8
29039595-6	2017	Caveolin-1 expression at the mRNA and protein levels was markedly increased following treatment with tert-butyl hydroperoxide, and an increase in premature senescence was observed, as determined by senescence-associated beta-galactosidase staining and the decline of cellular proliferative ability.	tert-Butylhydroperoxide	101-125	caveolin 1	Homo sapiens	0-10
28982326-10	2017	RESULTS: Injection of rats with t-BHP (1.8 mmol/kg) showed a significant increase in plasma alanine transaminases (ALT), aspartate transaminases (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and malondialdehyde (MDA) as well as hepatic tumor Necrosis Factor-alpha (TNF-alpha), interleukin- 6 (IL-6) and interleukin-23 (IL-23) when compared with control group.	tert-Butylhydroperoxide	32-37	PDZ and LIM domain 3	Rattus norvegicus	174-177
28982326-11	2017	Also, injection of rats with t-BHP showed a significant increase in a liver level of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) as compared with control group.	tert-Butylhydroperoxide	29-34	catalase	Rattus norvegicus	150-153
28982326-10	2017	RESULTS: Injection of rats with t-BHP (1.8 mmol/kg) showed a significant increase in plasma alanine transaminases (ALT), aspartate transaminases (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and malondialdehyde (MDA) as well as hepatic tumor Necrosis Factor-alpha (TNF-alpha), interleukin- 6 (IL-6) and interleukin-23 (IL-23) when compared with control group.	tert-Butylhydroperoxide	32-37	tumor necrosis factor	Rattus norvegicus	253-280
28982326-11	2017	Also, injection of rats with t-BHP showed a significant increase in a liver level of reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) as compared with control group.	tert-Butylhydroperoxide	29-34	hematopoietic prostaglandin D synthase	Rattus norvegicus	159-184
28982326-10	2017	RESULTS: Injection of rats with t-BHP (1.8 mmol/kg) showed a significant increase in plasma alanine transaminases (ALT), aspartate transaminases (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and malondialdehyde (MDA) as well as hepatic tumor Necrosis Factor-alpha (TNF-alpha), interleukin- 6 (IL-6) and interleukin-23 (IL-23) when compared with control group.	tert-Butylhydroperoxide	32-37	tumor necrosis factor	Rattus norvegicus	282-291
28982326-10	2017	RESULTS: Injection of rats with t-BHP (1.8 mmol/kg) showed a significant increase in plasma alanine transaminases (ALT), aspartate transaminases (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and malondialdehyde (MDA) as well as hepatic tumor Necrosis Factor-alpha (TNF-alpha), interleukin- 6 (IL-6) and interleukin-23 (IL-23) when compared with control group.	tert-Butylhydroperoxide	32-37	interleukin 6	Rattus norvegicus	294-308
28982326-10	2017	RESULTS: Injection of rats with t-BHP (1.8 mmol/kg) showed a significant increase in plasma alanine transaminases (ALT), aspartate transaminases (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and malondialdehyde (MDA) as well as hepatic tumor Necrosis Factor-alpha (TNF-alpha), interleukin- 6 (IL-6) and interleukin-23 (IL-23) when compared with control group.	tert-Butylhydroperoxide	32-37	interleukin 6	Rattus norvegicus	310-314
29072685-4	2017	Herein, we found SIRT3 protein expression is decreased in tert-butyl hydroperoxide (t-BHP)-treated AML12 cells in vitro and primary hepatocytes from CCl4-injured mice in vivo.	tert-Butylhydroperoxide	58-82	sirtuin 3	Mus musculus	17-22
28602161-8	2017	Up-regulation of HO-1 also confers protection to HepG2 cells from tertiary butyl hydroperoxide (TBH) induced cytotoxicity.	tert-Butylhydroperoxide	96-99	heme oxygenase 1	Homo sapiens	17-21
29072685-4	2017	Herein, we found SIRT3 protein expression is decreased in tert-butyl hydroperoxide (t-BHP)-treated AML12 cells in vitro and primary hepatocytes from CCl4-injured mice in vivo.	tert-Butylhydroperoxide	84-89	sirtuin 3	Mus musculus	17-22
28956925-1	2017	Thermal decomposition of t-butyl hydroperoxide and di-t-butyl peroxide was investigated using flash pyrolysis (in a short reaction time of <100 mus) and vacuum-ultraviolet (lambda = 118.2 nm) single-photon ionization time-of-flight mass spectrometry (VUV-SPI-TOFMS) at temperatures up to 1120 K and quantum computational methods.	tert-Butylhydroperoxide	25-46	chromogranin A	Homo sapiens	258-261
28982598-5	2017	Furthermore, Mlg exposure significantly lessened t-BHP-induced cytotoxicity and ROS production which were evidently abolished by treatment with AMPK and ERK inhibitors and Nrf2 siRNA.	tert-Butylhydroperoxide	49-54	NFE2 like bZIP transcription factor 2	Homo sapiens	172-176
28434171-0	2017	Peroxidatic cysteine residue of peroxiredoxin 2 separated from human red blood cells treated by tert-butyl hydroperoxide is hyperoxidized into sulfinic and sulfonic acids.	tert-Butylhydroperoxide	96-120	peroxiredoxin 2	Homo sapiens	32-47
28434171-4	2017	The LC-MS/MS analysis of the trypsin digests of Prx2 fractionated by reverse-phase HPLC demonstrated that the cysteine-51 residue (Cys-51) of the protein was modified with the hyperoxidative functional groups, sulfinic acid (-SO2H) and sulfonic acid (-SO3H), in RBCs treated with tert-butyl hydroperoxide (t-BHP).	tert-Butylhydroperoxide	280-304	peroxiredoxin 2	Homo sapiens	48-52
28434171-4	2017	The LC-MS/MS analysis of the trypsin digests of Prx2 fractionated by reverse-phase HPLC demonstrated that the cysteine-51 residue (Cys-51) of the protein was modified with the hyperoxidative functional groups, sulfinic acid (-SO2H) and sulfonic acid (-SO3H), in RBCs treated with tert-butyl hydroperoxide (t-BHP).	tert-Butylhydroperoxide	306-311	peroxiredoxin 2	Homo sapiens	48-52
28981117-9	2017	However, the anti-apoptotic effects of trehalose in TBHP-treated chondrocytes were partially abolished by autophagic flux inhibitor chloroquine and BNIP3- siRNA.	tert-Butylhydroperoxide	52-56	BCL2/adenovirus E1B interacting protein 3	Mus musculus	148-153
28982598-0	2017	Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3beta and ERK activation.	tert-Butylhydroperoxide	31-36	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
28982598-0	2017	Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3beta and ERK activation.	tert-Butylhydroperoxide	31-36	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	98-102
28982598-6	2017	Accordingly, Mlg might exhibit a protective role against t-BHP-triggered cytotoxicity via the activation of the AMPK/GSK3beta- and ERK-Nrf2 signaling pathways.	tert-Butylhydroperoxide	57-62	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	112-116
28982598-0	2017	Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3beta and ERK activation.	tert-Butylhydroperoxide	31-36	glycogen synthase kinase 3 beta	Homo sapiens	103-111
28982598-0	2017	Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3beta and ERK activation.	tert-Butylhydroperoxide	31-36	mitogen-activated protein kinase 1	Homo sapiens	116-119
28982598-6	2017	Accordingly, Mlg might exhibit a protective role against t-BHP-triggered cytotoxicity via the activation of the AMPK/GSK3beta- and ERK-Nrf2 signaling pathways.	tert-Butylhydroperoxide	57-62	glycogen synthase kinase 3 beta	Homo sapiens	117-125
28982598-5	2017	Furthermore, Mlg exposure significantly lessened t-BHP-induced cytotoxicity and ROS production which were evidently abolished by treatment with AMPK and ERK inhibitors and Nrf2 siRNA.	tert-Butylhydroperoxide	49-54	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	144-148
28982598-5	2017	Furthermore, Mlg exposure significantly lessened t-BHP-induced cytotoxicity and ROS production which were evidently abolished by treatment with AMPK and ERK inhibitors and Nrf2 siRNA.	tert-Butylhydroperoxide	49-54	mitogen-activated protein kinase 1	Homo sapiens	153-156
28982598-6	2017	Accordingly, Mlg might exhibit a protective role against t-BHP-triggered cytotoxicity via the activation of the AMPK/GSK3beta- and ERK-Nrf2 signaling pathways.	tert-Butylhydroperoxide	57-62	mitogen-activated protein kinase 1	Homo sapiens	131-134
28982598-6	2017	Accordingly, Mlg might exhibit a protective role against t-BHP-triggered cytotoxicity via the activation of the AMPK/GSK3beta- and ERK-Nrf2 signaling pathways.	tert-Butylhydroperoxide	57-62	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
28526614-7	2017	Furthermore, over-expression of the fused histidine-tagged ALDH3A1 confers host E. coli cells with enhanced resistance to thermal shock, while ALDH3A1 over-expression in the human corneal cell line HCE-2 was sufficient for protecting them from the cytotoxic effects of both hydrogen peroxide and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	296-320	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	59-66
28912527-5	2017	Blockade of NF-kappaB activation annulled the protective effects of CA and Res on apoptosis, ROS, and p53 activation in tBH-treated SK-N-SH-MJD78 cells, which suggests the importance of restoring NF-kappaB activity by CA and Res.	tert-Butylhydroperoxide	120-123	Relish	Drosophila melanogaster	12-21
28912527-5	2017	Blockade of NF-kappaB activation annulled the protective effects of CA and Res on apoptosis, ROS, and p53 activation in tBH-treated SK-N-SH-MJD78 cells, which suggests the importance of restoring NF-kappaB activity by CA and Res.	tert-Butylhydroperoxide	120-123	p53	Drosophila melanogaster	102-105
28912527-5	2017	Blockade of NF-kappaB activation annulled the protective effects of CA and Res on apoptosis, ROS, and p53 activation in tBH-treated SK-N-SH-MJD78 cells, which suggests the importance of restoring NF-kappaB activity by CA and Res.	tert-Butylhydroperoxide	120-123	Relish	Drosophila melanogaster	196-205
28526614-7	2017	Furthermore, over-expression of the fused histidine-tagged ALDH3A1 confers host E. coli cells with enhanced resistance to thermal shock, while ALDH3A1 over-expression in the human corneal cell line HCE-2 was sufficient for protecting them from the cytotoxic effects of both hydrogen peroxide and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	296-320	aldehyde dehydrogenase 3 family member A1	Homo sapiens	143-150
28285192-7	2017	Additionally, Xn evidently decreased t-BHP-stimulated cell apoptosis, ROS generation and GSH depletion but increased various anti-oxidative enzymes expression regulated by Keap1-Nrf2/ARE activation, which may be associated with AMPK and GSK3beta phosphorylation.	tert-Butylhydroperoxide	37-42	glycogen synthase kinase 3 beta	Mus musculus	237-245
28188924-0	2017	Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death.	tert-Butylhydroperoxide	66-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
28682601-3	2017	In this work, a three-component oxidative coupling of aryl aldehydes with alpha,beta-unsaturated esters and tert-butyl hydroperoxide catalyzed by dirhodium(II) catalyst Rh2(esp)2 (esp = alpha,alpha,alpha",alpha"-tetramethyl-1,3-benzenedipropanoate) under mild conditions is developed.	tert-Butylhydroperoxide	108-132	Rh associated glycoprotein	Homo sapiens	169-172
27913845-1	2017	In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), via F-actin disorganization followed by endocytic internalization of canalicular transporters relevant to bile formation (Mrp2, Bsep).	tert-Butylhydroperoxide	64-88	ATP binding cassette subfamily C member 2	Rattus norvegicus	343-347
27913845-1	2017	In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca2+-dependent protein kinase C isoforms (cPKC), via F-actin disorganization followed by endocytic internalization of canalicular transporters relevant to bile formation (Mrp2, Bsep).	tert-Butylhydroperoxide	64-88	ATP binding cassette subfamily B member 11	Rattus norvegicus	349-353
28489026-7	2017	Here, the role of tert-butyl hydroperoxide (t-BHP) in redox regulation of PTEN was analyzed by using cell-based and in vitro assays.	tert-Butylhydroperoxide	44-49	telomerase reverse transcriptase	Homo sapiens	18-22
28489026-7	2017	Here, the role of tert-butyl hydroperoxide (t-BHP) in redox regulation of PTEN was analyzed by using cell-based and in vitro assays.	tert-Butylhydroperoxide	44-49	phosphatase and tensin homolog	Homo sapiens	74-78
28489026-8	2017	Exposure to t-BHP led to oxidation of recombinant PTEN.	tert-Butylhydroperoxide	12-17	phosphatase and tensin homolog	Homo sapiens	50-54
28489026-9	2017	In contrast to H2O2, PTEN oxidation by t-BHP was irreversible in HeLa cells.	tert-Butylhydroperoxide	39-44	phosphatase and tensin homolog	Homo sapiens	21-25
28489026-11	2017	Taken together, these results indicate that t-BHP induces PTEN oxidation and inhibits Trx system, which results in irreversible PTEN oxidation in HeLa cells.	tert-Butylhydroperoxide	44-49	phosphatase and tensin homolog	Homo sapiens	58-62
28489026-11	2017	Taken together, these results indicate that t-BHP induces PTEN oxidation and inhibits Trx system, which results in irreversible PTEN oxidation in HeLa cells.	tert-Butylhydroperoxide	44-49	thioredoxin	Homo sapiens	86-89
28489026-11	2017	Taken together, these results indicate that t-BHP induces PTEN oxidation and inhibits Trx system, which results in irreversible PTEN oxidation in HeLa cells.	tert-Butylhydroperoxide	44-49	phosphatase and tensin homolog	Homo sapiens	128-132
28188924-0	2017	Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death.	tert-Butylhydroperoxide	92-97	nuclear factor, erythroid derived 2, like 2	Mus musculus	19-23
28188924-7	2017	Furthermore, Daph exposure suppressed t-BHP-induced cytotoxicity and ROS overproduction, which are mostly blocked in Nrf2 knockout RAW 264.7 cells and peritoneal macrophages.	tert-Butylhydroperoxide	38-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
28188924-8	2017	Accordingly, Daph exhibited protective roles against t-BHP-triggered oxidative damage and mitochondrial dysfunction by the upregulation of Nrf2 antioxidant signaling pathways, which may be involved in the activation of JNK and ERK.	tert-Butylhydroperoxide	53-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	139-143
28188924-8	2017	Accordingly, Daph exhibited protective roles against t-BHP-triggered oxidative damage and mitochondrial dysfunction by the upregulation of Nrf2 antioxidant signaling pathways, which may be involved in the activation of JNK and ERK.	tert-Butylhydroperoxide	53-58	mitogen-activated protein kinase 8	Mus musculus	219-222
28188924-8	2017	Accordingly, Daph exhibited protective roles against t-BHP-triggered oxidative damage and mitochondrial dysfunction by the upregulation of Nrf2 antioxidant signaling pathways, which may be involved in the activation of JNK and ERK.	tert-Butylhydroperoxide	53-58	mitogen-activated protein kinase 1	Mus musculus	227-230
28452956-10	2017	CA derivatives except OCA and HCA significantly suppressed t-BHP-induced hypoxia-inducible factor-1alpha (HIF-1alpha) protein level.	tert-Butylhydroperoxide	59-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	73-104
28452956-10	2017	CA derivatives except OCA and HCA significantly suppressed t-BHP-induced hypoxia-inducible factor-1alpha (HIF-1alpha) protein level.	tert-Butylhydroperoxide	59-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
28088644-0	2017	Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion.	tert-Butylhydroperoxide	0-24	NADPH oxidase 4	Homo sapiens	98-102
28110191-6	2017	Excitingly, Knockout of Nrf2 almost abolished AA-mediated antioxidant activity and cytoprotection against t-BHP.	tert-Butylhydroperoxide	106-111	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
28110191-9	2017	Furthermore, treatment with either Akt or ERK inhibitor also decreased AA-mediated cytoprotection against t-BHP-induced cellular damage.	tert-Butylhydroperoxide	106-111	AKT serine/threonine kinase 1	Homo sapiens	35-38
28110191-9	2017	Furthermore, treatment with either Akt or ERK inhibitor also decreased AA-mediated cytoprotection against t-BHP-induced cellular damage.	tert-Butylhydroperoxide	106-111	mitogen-activated protein kinase 1	Homo sapiens	42-45
28110191-10	2017	Collectively, these results presented in this study indicate that AA has the protective effect against t-BHP-induced cellular damage and oxidative stress by modulating Nrf2 signaling through activating the signals of Akt and ERK.	tert-Butylhydroperoxide	103-108	NFE2 like bZIP transcription factor 2	Homo sapiens	168-172
28110191-10	2017	Collectively, these results presented in this study indicate that AA has the protective effect against t-BHP-induced cellular damage and oxidative stress by modulating Nrf2 signaling through activating the signals of Akt and ERK.	tert-Butylhydroperoxide	103-108	AKT serine/threonine kinase 1	Homo sapiens	217-220
28110191-10	2017	Collectively, these results presented in this study indicate that AA has the protective effect against t-BHP-induced cellular damage and oxidative stress by modulating Nrf2 signaling through activating the signals of Akt and ERK.	tert-Butylhydroperoxide	103-108	mitogen-activated protein kinase 1	Homo sapiens	225-228
28088644-0	2017	Tert-butyl hydroperoxide (t-BHP) induced apoptosis and necroptosis in endothelial cells: Roles of NOX4 and mitochondrion.	tert-Butylhydroperoxide	26-31	NADPH oxidase 4	Homo sapiens	98-102
27959441-0	2017	Protective effects of Cambodian medicinal plants on tert-butyl hydroperoxide-induced hepatotoxicity via Nrf2-mediated heme oxygenase-1.	tert-Butylhydroperoxide	52-76	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
28212397-5	2017	Both methods showed that exposure to tBHP and Cd induced expression of prdx1, gstp1, and hmox1a (2- to 12-fold increase via QGP), indicative of an activated Nrf2 response in larval zebrafish.	tert-Butylhydroperoxide	37-41	peroxiredoxin 1	Danio rerio	71-76
28212397-5	2017	Both methods showed that exposure to tBHP and Cd induced expression of prdx1, gstp1, and hmox1a (2- to 12-fold increase via QGP), indicative of an activated Nrf2 response in larval zebrafish.	tert-Butylhydroperoxide	37-41	glutathione S-transferase pi 1.2	Danio rerio	78-83
28212397-5	2017	Both methods showed that exposure to tBHP and Cd induced expression of prdx1, gstp1, and hmox1a (2- to 12-fold increase via QGP), indicative of an activated Nrf2 response in larval zebrafish.	tert-Butylhydroperoxide	37-41	heme oxygenase 1a	Danio rerio	89-95
28212397-5	2017	Both methods showed that exposure to tBHP and Cd induced expression of prdx1, gstp1, and hmox1a (2- to 12-fold increase via QGP), indicative of an activated Nrf2 response in larval zebrafish.	tert-Butylhydroperoxide	37-41	nfe2 like bZIP transcription factor 2a	Danio rerio	157-161
27693501-8	2017	Sesn1 and 2 were increased by tBHP, an oxidative stress inducer.	tert-Butylhydroperoxide	30-34	sestrin 1	Homo sapiens	0-11
27766356-8	2017	Luciferase activity levels were also increased in a TRX2-promoter-driven luc2CP reporter strain treated with tert-butyl hydroperoxide and menadione and weakly induced with diamide and diethyl maleate.	tert-Butylhydroperoxide	109-133	thioredoxin TRX2	Saccharomyces cerevisiae S288C	52-56
28025122-0	2017	Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways.	tert-Butylhydroperoxide	42-47	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	115-121
28025122-0	2017	Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways.	tert-Butylhydroperoxide	42-47	AKT serine/threonine kinase 1	Homo sapiens	122-125
28025122-0	2017	Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways.	tert-Butylhydroperoxide	42-47	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
28025122-4	2017	Pretreatment with rutaecarpine prior to the injection of t-BHP significantly prevented the increase in serum levels of AST, ALT, and lipid peroxidation in mice liver.	tert-Butylhydroperoxide	57-62	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	119-122
28025122-4	2017	Pretreatment with rutaecarpine prior to the injection of t-BHP significantly prevented the increase in serum levels of AST, ALT, and lipid peroxidation in mice liver.	tert-Butylhydroperoxide	57-62	glutamic pyruvic transaminase, soluble	Mus musculus	124-127
27109168-0	2017	Regucalcin counteracts tert-butyl hydroperoxide and cadmium-induced oxidative stress in rat testis.	tert-Butylhydroperoxide	23-47	regucalcin	Rattus norvegicus	0-10
27109168-7	2017	The activity of apoptosis executioner caspase-3 was significantly increased in the SeT of WT rats treated with 250 muM of TBHP or 10 muM of Cd, an effect not seen in Tg-RGN animals.	tert-Butylhydroperoxide	122-126	caspase 3	Rattus norvegicus	38-47
27959441-0	2017	Protective effects of Cambodian medicinal plants on tert-butyl hydroperoxide-induced hepatotoxicity via Nrf2-mediated heme oxygenase-1.	tert-Butylhydroperoxide	52-76	heme oxygenase 1	Homo sapiens	118-134
27959441-9	2017	These results indicated that, of the 64 Cambodian plants, P. weberi and T. crispa exhibited hepatoprotective effects on t-BHP-induced cytotoxicity in HepG2 cells, possibly by the induction of Nrf2-mediated expression of HO-1.	tert-Butylhydroperoxide	120-125	NFE2 like bZIP transcription factor 2	Homo sapiens	192-196
27959441-9	2017	These results indicated that, of the 64 Cambodian plants, P. weberi and T. crispa exhibited hepatoprotective effects on t-BHP-induced cytotoxicity in HepG2 cells, possibly by the induction of Nrf2-mediated expression of HO-1.	tert-Butylhydroperoxide	120-125	heme oxygenase 1	Homo sapiens	220-224
29362666-7	2017	From the perspective of hepatoprotection, VCAF exhibited a significant protective effect on t-BHP-induced HepG2 cell injury, as indicated by reductions in cytotoxicity and the levels of ROS, 8-hydroxydeoxyguanosine (8-OHdG), and protein carbonyls.	tert-Butylhydroperoxide	92-97	host cell factor C1	Homo sapiens	42-46
29362666-8	2017	Further study demonstrated that VCAF attenuated the apoptosis of t-BHP-treated HepG2 cells by suppressing the activation of caspase-3 and caspase-8.	tert-Butylhydroperoxide	65-70	host cell factor C1	Homo sapiens	32-36
29362666-8	2017	Further study demonstrated that VCAF attenuated the apoptosis of t-BHP-treated HepG2 cells by suppressing the activation of caspase-3 and caspase-8.	tert-Butylhydroperoxide	65-70	caspase 3	Homo sapiens	124-133
29362666-8	2017	Further study demonstrated that VCAF attenuated the apoptosis of t-BHP-treated HepG2 cells by suppressing the activation of caspase-3 and caspase-8.	tert-Butylhydroperoxide	65-70	caspase 8	Homo sapiens	138-147
27836324-8	2016	Interestingly, homozygous A. thaliana arp-/- mutant exhibited high sensitivity to methyl methanesulfonate and tert-butyl hydroperoxide, but not to H2O2, suggesting that ARP is a major plant AP endonuclease that removes abasic sites and specific types of oxidative DNA base damage.	tert-Butylhydroperoxide	110-134	apurinic endonuclease-redox protein	Arabidopsis thaliana	38-41
27836324-8	2016	Interestingly, homozygous A. thaliana arp-/- mutant exhibited high sensitivity to methyl methanesulfonate and tert-butyl hydroperoxide, but not to H2O2, suggesting that ARP is a major plant AP endonuclease that removes abasic sites and specific types of oxidative DNA base damage.	tert-Butylhydroperoxide	110-134	apurinic endonuclease-redox protein	Arabidopsis thaliana	169-172
27396622-0	2016	Down-regulation of Homer1 attenuates t-BHP-induced oxidative stress through regulating calcium homeostasis and ER stress in brain endothelial cells.	tert-Butylhydroperoxide	37-42	homer scaffolding protein 1	Mus musculus	19-25
27696911-6	2016	CryalphaA-specific shRNA lentivirus was used to knockdown alphaA-crystallin in LEC-derived iPSC-like cells, which were treated with tert-Butyl hydroperoxide.	tert-Butylhydroperoxide	132-156	C-C motif chemokine ligand 16	Homo sapiens	79-82
27907038-12	2016	Importantly, Nrf2 siRNA interference induced CHOP and attenuated the effect of equol to inhibit t-BHP mediated CHOP induction, furthermore, abrogated cell apoptosis induced by t-BHP, suggesting a role for Nrf2 in the protective effect of equol in HUVECs.	tert-Butylhydroperoxide	96-101	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
27907038-12	2016	Importantly, Nrf2 siRNA interference induced CHOP and attenuated the effect of equol to inhibit t-BHP mediated CHOP induction, furthermore, abrogated cell apoptosis induced by t-BHP, suggesting a role for Nrf2 in the protective effect of equol in HUVECs.	tert-Butylhydroperoxide	96-101	DNA-damage inducible transcript 3	Mus musculus	111-115
27907038-12	2016	Importantly, Nrf2 siRNA interference induced CHOP and attenuated the effect of equol to inhibit t-BHP mediated CHOP induction, furthermore, abrogated cell apoptosis induced by t-BHP, suggesting a role for Nrf2 in the protective effect of equol in HUVECs.	tert-Butylhydroperoxide	96-101	nuclear factor, erythroid derived 2, like 2	Mus musculus	205-209
27907038-12	2016	Importantly, Nrf2 siRNA interference induced CHOP and attenuated the effect of equol to inhibit t-BHP mediated CHOP induction, furthermore, abrogated cell apoptosis induced by t-BHP, suggesting a role for Nrf2 in the protective effect of equol in HUVECs.	tert-Butylhydroperoxide	176-181	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
27716579-8	2016	Comparing diquat and tBOOH exposed embryos relative to the WT untreated control, a greater number of genes were up-regulated in the tBOOH condition as compared to diquat (tBOOH: 304 vs diquat: 148), including those commonly found to be differentially regulated in the vertebrate oxidative stress response (OSR) (e.g. hsp70.2, txn1, and gsr).	tert-Butylhydroperoxide	21-26	heat shock cognate 70-kd protein, tandem duplicate 2	Danio rerio	317-324
27716579-8	2016	Comparing diquat and tBOOH exposed embryos relative to the WT untreated control, a greater number of genes were up-regulated in the tBOOH condition as compared to diquat (tBOOH: 304 vs diquat: 148), including those commonly found to be differentially regulated in the vertebrate oxidative stress response (OSR) (e.g. hsp70.2, txn1, and gsr).	tert-Butylhydroperoxide	21-26	thioredoxin	Danio rerio	326-330
27522666-4	2016	We aimed to investigate the effects of Ginsenoside Rg1 on protecting hUCBDSCs from t-BHP-induced oxidative injury and apoptosis, as well as the possible signaling pathway involved.	tert-Butylhydroperoxide	83-88	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	51-54
27522666-5	2016	It was shown that the treatment of hUCBDSCs with G-Rg1 markedly restored the t-BHP-induced cell viability loss, promoted the CFU-F formation, and inhibited cell apoptosis.	tert-Butylhydroperoxide	77-82	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	51-54
27522666-8	2016	All these results suggest that G-Rg1 enhances the survival of t-BHP-induced hUCBDSCs and protects them against apoptosis at least partially through Akt-FoxO3a-Bim signaling pathway.	tert-Butylhydroperoxide	62-67	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	33-36
27522666-8	2016	All these results suggest that G-Rg1 enhances the survival of t-BHP-induced hUCBDSCs and protects them against apoptosis at least partially through Akt-FoxO3a-Bim signaling pathway.	tert-Butylhydroperoxide	62-67	forkhead box O3	Homo sapiens	152-158
27396622-5	2016	Knockdown of Homer1 using specific siRNA significantly alleviated lactate dehydrogenase (LDH) release, increased cell viability, and ultimately decreased apoptosis after t-BHP treatment.	tert-Butylhydroperoxide	170-175	homer scaffolding protein 1	Mus musculus	13-19
27396622-6	2016	Moreover, Homer1 knockdown attenuated t-BHP-induced ROS generation, lipid peroxidation and mitochondrial dysfunction, as evidenced by loss of mitochondrial membrane potential (MMP), ATP synthesis collapse and mitochondrial swelling.	tert-Butylhydroperoxide	38-43	homer scaffolding protein 1	Mus musculus	10-16
27396622-7	2016	The results of Ca(2+) imaging showed that Homer1 was involved in inositol trisphosphate receptors (IP3R)- and ryanodine receptor (RyR)-mediated intracellular Ca(2+) release, and also mediated t-BHP-induced Ca(2+) release from the endoplasmic reticulum (ER).	tert-Butylhydroperoxide	192-197	homer scaffolding protein 1	Mus musculus	42-48
27396622-7	2016	The results of Ca(2+) imaging showed that Homer1 was involved in inositol trisphosphate receptors (IP3R)- and ryanodine receptor (RyR)-mediated intracellular Ca(2+) release, and also mediated t-BHP-induced Ca(2+) release from the endoplasmic reticulum (ER).	tert-Butylhydroperoxide	192-197	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	99-103
27396622-7	2016	The results of Ca(2+) imaging showed that Homer1 was involved in inositol trisphosphate receptors (IP3R)- and ryanodine receptor (RyR)-mediated intracellular Ca(2+) release, and also mediated t-BHP-induced Ca(2+) release from the endoplasmic reticulum (ER).	tert-Butylhydroperoxide	192-197	ryanodine receptor 1, skeletal muscle	Mus musculus	110-128
27396622-7	2016	The results of Ca(2+) imaging showed that Homer1 was involved in inositol trisphosphate receptors (IP3R)- and ryanodine receptor (RyR)-mediated intracellular Ca(2+) release, and also mediated t-BHP-induced Ca(2+) release from the endoplasmic reticulum (ER).	tert-Butylhydroperoxide	192-197	ryanodine receptor 1, skeletal muscle	Mus musculus	130-133
27396622-8	2016	In addition, knockdown of Homer1 significantly prevented activation of ER stress markers induced by t-BHP exposure.	tert-Butylhydroperoxide	100-105	homer scaffolding protein 1	Mus musculus	26-32
27396622-9	2016	All these results showed that Homer1 is involved in t-BHP-induced endothelial dysfunction in mBECs, and may be an ideal candidate for searching gene intervention strategy for preventing endothelial oxidative stress in vitro.	tert-Butylhydroperoxide	52-57	homer scaffolding protein 1	Mus musculus	30-36
27183873-5	2016	Using the heme oxygenase-1 (HO-1) as a model of phase II enzyme gene, we found that methylation of Nrf2 by PRMT1 led to a moderate increase of its DNA-binding activity and transactivation, which subsequently protected cells against the tBHP-induced glutathione depletion and cell death.	tert-Butylhydroperoxide	236-240	heme oxygenase 1	Homo sapiens	10-26
27425215-10	2016	In vitro, NecroX-7 prevented tert-butyl hydroperoxide (tBHP)-induced mitochondrial ROS formation, necrosis, iNOS expression and HMGB1 release in primary macrophages.	tert-Butylhydroperoxide	29-53	nitric oxide synthase 2, inducible	Mus musculus	108-112
27425215-10	2016	In vitro, NecroX-7 prevented tert-butyl hydroperoxide (tBHP)-induced mitochondrial ROS formation, necrosis, iNOS expression and HMGB1 release in primary macrophages.	tert-Butylhydroperoxide	29-53	high mobility group box 1	Mus musculus	128-133
27425215-10	2016	In vitro, NecroX-7 prevented tert-butyl hydroperoxide (tBHP)-induced mitochondrial ROS formation, necrosis, iNOS expression and HMGB1 release in primary macrophages.	tert-Butylhydroperoxide	55-59	nitric oxide synthase 2, inducible	Mus musculus	108-112
27425215-10	2016	In vitro, NecroX-7 prevented tert-butyl hydroperoxide (tBHP)-induced mitochondrial ROS formation, necrosis, iNOS expression and HMGB1 release in primary macrophages.	tert-Butylhydroperoxide	55-59	high mobility group box 1	Mus musculus	128-133
27183873-5	2016	Using the heme oxygenase-1 (HO-1) as a model of phase II enzyme gene, we found that methylation of Nrf2 by PRMT1 led to a moderate increase of its DNA-binding activity and transactivation, which subsequently protected cells against the tBHP-induced glutathione depletion and cell death.	tert-Butylhydroperoxide	236-240	heme oxygenase 1	Homo sapiens	28-32
27183873-5	2016	Using the heme oxygenase-1 (HO-1) as a model of phase II enzyme gene, we found that methylation of Nrf2 by PRMT1 led to a moderate increase of its DNA-binding activity and transactivation, which subsequently protected cells against the tBHP-induced glutathione depletion and cell death.	tert-Butylhydroperoxide	236-240	NFE2 like bZIP transcription factor 2	Homo sapiens	99-103
27183873-5	2016	Using the heme oxygenase-1 (HO-1) as a model of phase II enzyme gene, we found that methylation of Nrf2 by PRMT1 led to a moderate increase of its DNA-binding activity and transactivation, which subsequently protected cells against the tBHP-induced glutathione depletion and cell death.	tert-Butylhydroperoxide	236-240	protein arginine methyltransferase 1	Homo sapiens	107-112
27190261-0	2016	Isotetrandrine ameliorates tert-butyl hydroperoxide-induced oxidative stress through upregulation of heme oxygenase-1 expression.	tert-Butylhydroperoxide	27-51	heme oxygenase 1	Homo sapiens	101-117
27208630-5	2016	Fibroblasts from Surf1(-/-) mice are significantly more resistant to cell death caused by oxidative stress induced by paraquat or tert-Butyl hydroperoxide compared to cells from wild-type mice.	tert-Butylhydroperoxide	130-154	surfeit gene 1	Mus musculus	17-22
27208630-7	2016	The enhanced cell survival in response to paraquat or tert-Butyl hydroperoxide in Surf1(-/-) fibroblasts compared to wild-type fibroblasts is associated with induced expression of Lon, ClpP, and Hsp60, increased maximal respiration, and increased reserve capacity as measured using the Seahorse Extracellular Flux Analyzer.	tert-Butylhydroperoxide	54-78	surfeit gene 1	Mus musculus	82-87
27208630-7	2016	The enhanced cell survival in response to paraquat or tert-Butyl hydroperoxide in Surf1(-/-) fibroblasts compared to wild-type fibroblasts is associated with induced expression of Lon, ClpP, and Hsp60, increased maximal respiration, and increased reserve capacity as measured using the Seahorse Extracellular Flux Analyzer.	tert-Butylhydroperoxide	54-78	lon peptidase 1, mitochondrial	Mus musculus	180-183
27208630-7	2016	The enhanced cell survival in response to paraquat or tert-Butyl hydroperoxide in Surf1(-/-) fibroblasts compared to wild-type fibroblasts is associated with induced expression of Lon, ClpP, and Hsp60, increased maximal respiration, and increased reserve capacity as measured using the Seahorse Extracellular Flux Analyzer.	tert-Butylhydroperoxide	54-78	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Mus musculus	185-189
27208630-7	2016	The enhanced cell survival in response to paraquat or tert-Butyl hydroperoxide in Surf1(-/-) fibroblasts compared to wild-type fibroblasts is associated with induced expression of Lon, ClpP, and Hsp60, increased maximal respiration, and increased reserve capacity as measured using the Seahorse Extracellular Flux Analyzer.	tert-Butylhydroperoxide	54-78	heat shock protein 1 (chaperonin)	Mus musculus	195-200
26989860-3	2016	We aimed to determine the role of SCAD in tert-butyl hydroperoxide (tBHP)-induced cardiomyocyte apoptosis.	tert-Butylhydroperoxide	42-66	acyl-CoA dehydrogenase short chain	Homo sapiens	34-38
26989860-3	2016	We aimed to determine the role of SCAD in tert-butyl hydroperoxide (tBHP)-induced cardiomyocyte apoptosis.	tert-Butylhydroperoxide	68-72	acyl-CoA dehydrogenase short chain	Homo sapiens	34-38
26989860-6	2016	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as cardiomyocytes treated with tBHP, such as the increase in cell apoptotic rate, the activation of caspase3 and the decrease in the Bcl-2/Bax ratio, which showed that SCAD may play an important role in primary cardiomyocyte apoptosis.	tert-Butylhydroperoxide	92-96	acyl-CoA dehydrogenase short chain	Homo sapiens	11-15
26989860-6	2016	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as cardiomyocytes treated with tBHP, such as the increase in cell apoptotic rate, the activation of caspase3 and the decrease in the Bcl-2/Bax ratio, which showed that SCAD may play an important role in primary cardiomyocyte apoptosis.	tert-Butylhydroperoxide	92-96	caspase 3	Homo sapiens	161-169
26989860-6	2016	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as cardiomyocytes treated with tBHP, such as the increase in cell apoptotic rate, the activation of caspase3 and the decrease in the Bcl-2/Bax ratio, which showed that SCAD may play an important role in primary cardiomyocyte apoptosis.	tert-Butylhydroperoxide	92-96	BCL2 apoptosis regulator	Homo sapiens	194-199
26989860-6	2016	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as cardiomyocytes treated with tBHP, such as the increase in cell apoptotic rate, the activation of caspase3 and the decrease in the Bcl-2/Bax ratio, which showed that SCAD may play an important role in primary cardiomyocyte apoptosis.	tert-Butylhydroperoxide	92-96	BCL2 associated X, apoptosis regulator	Homo sapiens	200-203
26989860-6	2016	Meanwhile, SCAD siRNA treatment triggered the same apoptosis as cardiomyocytes treated with tBHP, such as the increase in cell apoptotic rate, the activation of caspase3 and the decrease in the Bcl-2/Bax ratio, which showed that SCAD may play an important role in primary cardiomyocyte apoptosis.	tert-Butylhydroperoxide	92-96	acyl-CoA dehydrogenase short chain	Homo sapiens	229-233
27030608-0	2016	Exendin-4 protects HUVECs from t-BHP-induced apoptosis via PI3K/Akt-Bcl-2-caspase-3 signaling.	tert-Butylhydroperoxide	31-36	AKT serine/threonine kinase 1	Homo sapiens	64-67
27030608-0	2016	Exendin-4 protects HUVECs from t-BHP-induced apoptosis via PI3K/Akt-Bcl-2-caspase-3 signaling.	tert-Butylhydroperoxide	31-36	BCL2 apoptosis regulator	Homo sapiens	68-73
27030608-0	2016	Exendin-4 protects HUVECs from t-BHP-induced apoptosis via PI3K/Akt-Bcl-2-caspase-3 signaling.	tert-Butylhydroperoxide	31-36	caspase 3	Homo sapiens	74-83
27030608-8	2016	Exendin-4 downregulated caspase-3 activity and increased Bcl-2 protein levels in t-BHP-treated HUVECs.	tert-Butylhydroperoxide	81-86	BCL2 apoptosis regulator	Homo sapiens	57-62
27030608-10	2016	Exendin-4 reversed t-BHP-mediated inhibition of Akt phosphorylation, which was abrogated by the PI3K inhibitor, wortmannin.	tert-Butylhydroperoxide	19-24	AKT serine/threonine kinase 1	Homo sapiens	48-51
27190261-8	2016	These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation.	tert-Butylhydroperoxide	68-92	heme oxygenase 1	Homo sapiens	142-158
27190261-8	2016	These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation.	tert-Butylhydroperoxide	68-92	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
27190261-8	2016	These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation.	tert-Butylhydroperoxide	68-92	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
27190261-8	2016	These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation.	tert-Butylhydroperoxide	68-92	kelch like ECH associated protein 1	Homo sapiens	208-213
27190261-8	2016	These results indicated that the 1R, 1"S-isotetrandrine ameliorated tert-butyl hydroperoxide-induced oxidative damage through upregulation of heme oxygenase-1 expression by the dissociation of Nrf2 from Nrf2-Keap1 complex via extracellular signal-regulated protein kinase and c-Jun NH2-terminal kinase activation and Keap1 inactivation.	tert-Butylhydroperoxide	68-92	kelch like ECH associated protein 1	Homo sapiens	317-322
27226119-0	2016	Visible Light Driven Photocascade Catalysis: Ru(bpy)3(PF6)2/TBHP-Mediated Synthesis of Fused beta-Carbolines in Batch and Flow Microreactors.	tert-Butylhydroperoxide	60-64	sperm associated antigen 17	Homo sapiens	54-57
27226119-1	2016	1,2,3,4-Tetrahydro-beta-carbolines were coupled with alpha-keto vinyl azides through an unprecedented visible light-Ru(bpy)3(PF6)2/TBHP mediated photocascade strategy that involves photosensitization, photoredox catalysis and [3 + 2] cycloaddition reaction.	tert-Butylhydroperoxide	131-135	sperm associated antigen 17	Homo sapiens	125-128
26806551-8	2016	Furthermore, inhibition of miR-21 with a lentiviral vector in DDAH1(-/-) MEFs significantly upregulated SOD2 expression and the attenuated oxidative stress and apoptosis induced by tBHP or A23187.	tert-Butylhydroperoxide	181-185	microRNA 21a	Mus musculus	27-33
26968794-4	2016	In this study, we demonstrated that GLP-1 was able to effectively inhibit oxidative stress and cell death of INS-1E beta cells induced by the pro-oxidant tert-butyl hydroperoxide (tert-BOOH).	tert-Butylhydroperoxide	154-178	glucagon	Rattus norvegicus	36-41
26968794-4	2016	In this study, we demonstrated that GLP-1 was able to effectively inhibit oxidative stress and cell death of INS-1E beta cells induced by the pro-oxidant tert-butyl hydroperoxide (tert-BOOH).	tert-Butylhydroperoxide	154-178	insulin 1	Rattus norvegicus	109-114
26948765-7	2016	Cell apoptosis was increased and molecule expressions of the JNK signalling pathway were activated in the tBHP-injured chondrocytes.	tert-Butylhydroperoxide	106-110	mitogen-activated protein kinase 8	Homo sapiens	61-64
26948765-8	2016	Na2SeO3 protected against tBHP-induced oxidative stress and apoptosis in cells by increasing cell viability, reducing reactive oxygen species generation, increasing Glutathione peroxidase (GPx) activity and down-regulating the JNK pathway.	tert-Butylhydroperoxide	26-30	mitogen-activated protein kinase 8	Homo sapiens	227-230
26948765-9	2016	These results demonstrate that apoptosis induced by tBHP in chondrocytes might be mediated via up-regulation of the JNK pathway; Na2SeO3 has an effect of anti-apoptosis by down-regulating the JNK signalling pathway.	tert-Butylhydroperoxide	52-56	mitogen-activated protein kinase 8	Homo sapiens	116-119
29926623-0	2016	[The Effect of recombinant adiponectin on apoptosis induced by t-BHP in human umbilical vein endothelial cells].	tert-Butylhydroperoxide	63-68	adiponectin, C1Q and collagen domain containing	Homo sapiens	27-38
29926623-1	2016	OBJECTIVE: To investigate the protective effect and possible mechanism of recombinant adiponectin on apoptosis in Human Umbilical Vein Endothelial Cells (HUVECs) induced by tert-butyl hydroperoxide (t-BHP).	tert-Butylhydroperoxide	173-197	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
29926623-1	2016	OBJECTIVE: To investigate the protective effect and possible mechanism of recombinant adiponectin on apoptosis in Human Umbilical Vein Endothelial Cells (HUVECs) induced by tert-butyl hydroperoxide (t-BHP).	tert-Butylhydroperoxide	199-204	adiponectin, C1Q and collagen domain containing	Homo sapiens	86-97
29926623-11	2016	Recombinant adiponectin protected HUVECs from apoptosis induced by t-BHP, which was correlated with the downregulation of p-JNK and active Caspase 3.	tert-Butylhydroperoxide	67-72	adiponectin, C1Q and collagen domain containing	Homo sapiens	12-23
29926623-11	2016	Recombinant adiponectin protected HUVECs from apoptosis induced by t-BHP, which was correlated with the downregulation of p-JNK and active Caspase 3.	tert-Butylhydroperoxide	67-72	mitogen-activated protein kinase 8	Homo sapiens	124-127
29926623-11	2016	Recombinant adiponectin protected HUVECs from apoptosis induced by t-BHP, which was correlated with the downregulation of p-JNK and active Caspase 3.	tert-Butylhydroperoxide	67-72	caspase 3	Homo sapiens	139-148
26935530-8	2016	Among the four ginsenosides, only Rb1 attenuated t-BHP toxicity in the NPCs, and the nuclear factor (erythroizd-derived 2)-like 2/heme oxygenase-1 pathway was found to be key in the intracellular defense against oxidative stress.	tert-Butylhydroperoxide	49-54	RB transcriptional corepressor 1	Rattus norvegicus	34-37
26806551-8	2016	Furthermore, inhibition of miR-21 with a lentiviral vector in DDAH1(-/-) MEFs significantly upregulated SOD2 expression and the attenuated oxidative stress and apoptosis induced by tBHP or A23187.	tert-Butylhydroperoxide	181-185	dimethylarginine dimethylaminohydrolase 1	Mus musculus	62-67
26102008-4	2016	tBHP-induced reactive oxygen species production and cell death in hepatocytes were blocked by oxyresveratrol, as indicated by MTT, TUNEL, and FACS analyses.	tert-Butylhydroperoxide	0-4	acyl-CoA synthetase long-chain family member 1	Mus musculus	142-146
26990160-3	2016	Human RPE cells were treated with 150 muM tert-Butyl hydroperoxide (tBH) in the absence/presence of HN (0.5-10 mug/mL) for 24 hours.	tert-Butylhydroperoxide	68-71	ribulose-5-phosphate-3-epimerase	Homo sapiens	6-9
26879328-0	2016	Azilsartan, an angiotensin II type 1 receptor blocker, attenuates tert-butyl hydroperoxide-induced endothelial cell injury through inhibition of mitochondrial dysfunction and anti-inflammatory activity.	tert-Butylhydroperoxide	66-90	angiotensin II, type I receptor-associated protein	Mus musculus	15-45
25715660-6	2016	t-BHP-induced elevations in hepatocyte alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase activities were reduced by SRP70 in a dose-dependent manner.	tert-Butylhydroperoxide	0-5	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	65-91
26806551-4	2016	DDAH1 deficiency significantly increased ADMA levels, enhanced cellular oxidative stress, and rendered cells more vulnerable to apoptosis induced by tert-butyl hydroperoxide (tBHP) or A23187.	tert-Butylhydroperoxide	149-173	dimethylarginine dimethylaminohydrolase 1	Mus musculus	0-5
26806551-4	2016	DDAH1 deficiency significantly increased ADMA levels, enhanced cellular oxidative stress, and rendered cells more vulnerable to apoptosis induced by tert-butyl hydroperoxide (tBHP) or A23187.	tert-Butylhydroperoxide	175-179	dimethylarginine dimethylaminohydrolase 1	Mus musculus	0-5
25715660-9	2016	In particular, SRP70 increased the activities of liver antioxidant enzymes in t-BHP-treated mice, including catalase and glutathione peroxidase, as well as increasing the level of glutathione, an antioxidant peptide.	tert-Butylhydroperoxide	78-83	catalase	Mus musculus	108-116
26052623-6	2016	The protective effects of isolated compounds (10 and 20 muM) against oxidative stress induced by tert-butyl hydroperoxide (t-BHP) in HepG2 cells were investigated through the measurement of aspartate aminotransferase (AST), alanine transaminase (ALT), and superoxide dismutase (SOD) levels.	tert-Butylhydroperoxide	97-121	latexin	Homo sapiens	56-59
26643580-1	2016	The dirhodium(II) carboxylate complex Rh2(esp)2 (esp = alpha,alpha,alpha",alpha"-tetramethyl-1,3-benzenedipropanoate) was shown to catalyze the sulfoxidation of organic sulfides using tert-butyl hydroperoxide as the oxidant.	tert-Butylhydroperoxide	184-208	Rh associated glycoprotein	Homo sapiens	38-41
27656262-10	2016	Collectively, our current data indicated that apigenin exerted potent antioxidant properties in ARPE-19 cells challenged with t-BHP, which were dependent on activation of Nrf2 signaling.	tert-Butylhydroperoxide	126-131	NFE2 like bZIP transcription factor 2	Homo sapiens	171-175
27551496-3	2016	These cells were incubated in several oxidative stress environments (exposure to high glucose and oxidizing agent tert-butylhydroperoxide) which led to mitochondrial permeability transition pore (PTP) opening, cytochrome c release and cell death.	tert-Butylhydroperoxide	114-137	cytochrome c, somatic	Homo sapiens	210-222
26052623-6	2016	The protective effects of isolated compounds (10 and 20 muM) against oxidative stress induced by tert-butyl hydroperoxide (t-BHP) in HepG2 cells were investigated through the measurement of aspartate aminotransferase (AST), alanine transaminase (ALT), and superoxide dismutase (SOD) levels.	tert-Butylhydroperoxide	123-128	latexin	Homo sapiens	56-59
26052623-8	2016	Oxidant-induced damage by 200 muM t-BHP in HepG2 cells was inhibited by compounds 1, 4, and 5 (10 and 20 muM), or quercetin (10 muM; positive control).	tert-Butylhydroperoxide	34-39	latexin	Homo sapiens	30-33
26052623-8	2016	Oxidant-induced damage by 200 muM t-BHP in HepG2 cells was inhibited by compounds 1, 4, and 5 (10 and 20 muM), or quercetin (10 muM; positive control).	tert-Butylhydroperoxide	34-39	latexin	Homo sapiens	105-108
26052623-8	2016	Oxidant-induced damage by 200 muM t-BHP in HepG2 cells was inhibited by compounds 1, 4, and 5 (10 and 20 muM), or quercetin (10 muM; positive control).	tert-Butylhydroperoxide	34-39	latexin	Homo sapiens	105-108
30873452-11	2015	Exposure of OS cell to ROS derived from tBHP was able to accelerate cell proliferation and migration and also up-regulate NHE1 protein expression.	tert-Butylhydroperoxide	40-44	solute carrier family 9 member A1	Homo sapiens	122-126
30873452-12	2015	Moreover, tBHP significantly increased intracellular pH (pHi), decreased extracellular pH (pHe) and induced upregulation of ERK, MMP2, and MMP9.	tert-Butylhydroperoxide	10-14	glucose-6-phosphate isomerase	Homo sapiens	57-60
30873452-12	2015	Moreover, tBHP significantly increased intracellular pH (pHi), decreased extracellular pH (pHe) and induced upregulation of ERK, MMP2, and MMP9.	tert-Butylhydroperoxide	10-14	matrix metallopeptidase 2	Homo sapiens	129-133
30873452-12	2015	Moreover, tBHP significantly increased intracellular pH (pHi), decreased extracellular pH (pHe) and induced upregulation of ERK, MMP2, and MMP9.	tert-Butylhydroperoxide	10-14	matrix metallopeptidase 9	Homo sapiens	139-143
30873452-13	2015	Lowering of ROS levels with the anti-oxidant DMTU or inhibiting NHE1 activity via cariporide abolished the stimulatory effect of tBHP.	tert-Butylhydroperoxide	129-133	solute carrier family 9 member A1	Homo sapiens	64-68
25880604-6	2015	IL-1beta treatment prevented the increase in reactive oxygen species produced in astrocytes following tBOOH exposure.	tert-Butylhydroperoxide	102-107	interleukin 1 beta	Mus musculus	0-8
26488108-0	2015	Transition-Metal-Free Synthesis of Carbonyl-Containing Oxindoles from N-Arylacrylamides and alpha-Diketones via TBHP- or Oxone-Mediated Oxidative Cleavage of C(sp(2))-C(sp(2)) Bonds.	tert-Butylhydroperoxide	112-116	regulator of calcineurin 2	Homo sapiens	158-165
26488108-1	2015	Carbonyl-containing oxindoles can be prepared from N-arylacrylamides and alpha-diketones by TBHP- or oxone (KHSO5)-mediated C(sp(2))-C(sp(2)) bond cleavage and new C(sp(2))-C(sp(3)) bond formation.	tert-Butylhydroperoxide	92-97	regulator of calcineurin 2	Homo sapiens	124-131
26488108-1	2015	Carbonyl-containing oxindoles can be prepared from N-arylacrylamides and alpha-diketones by TBHP- or oxone (KHSO5)-mediated C(sp(2))-C(sp(2)) bond cleavage and new C(sp(2))-C(sp(3)) bond formation.	tert-Butylhydroperoxide	92-97	regulator of calcineurin 2	Homo sapiens	133-140
26165373-9	2015	Compared with the t-BHP treatment group (20.0+-3.8%), the number of annexin V-positive cells decreased dose-dependently to 13.6+-2.6, 9.8+-0.5 and 7.4+-2.0% in the SS-31 treated group at concentrations of 10 nM, 100 nM and 1 microM, respectively.	tert-Butylhydroperoxide	18-23	annexin A5	Mus musculus	68-77
26275128-6	2015	The detoxifying/antioxidant genes activated by t-CA, especially heme oxygenase-1 (HO-1), were found to be involved in its cytoprotective effects against oxidative stress and cell injuries elicited by carcinogens tert-butylhydroperoxide and arecoline.	tert-Butylhydroperoxide	212-235	heme oxygenase 1	Homo sapiens	64-80
26275128-6	2015	The detoxifying/antioxidant genes activated by t-CA, especially heme oxygenase-1 (HO-1), were found to be involved in its cytoprotective effects against oxidative stress and cell injuries elicited by carcinogens tert-butylhydroperoxide and arecoline.	tert-Butylhydroperoxide	212-235	heme oxygenase 1	Homo sapiens	82-86
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	10-34	mitogen-activated protein kinase 14	Mus musculus	162-165
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	10-34	mitogen-activated protein kinase 1	Mus musculus	167-170
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	10-34	heme oxygenase 1	Mus musculus	175-179
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	36-41	mitogen-activated protein kinase 14	Mus musculus	162-165
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	36-41	mitogen-activated protein kinase 1	Mus musculus	167-170
26111761-8	2015	Moreover, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was ameliorated by farrerol treatment in a dose-dependent manner, which was abolished by Akt, p38, ERK and HO-1 inhibitors (Snpp).	tert-Butylhydroperoxide	36-41	heme oxygenase 1	Mus musculus	175-179
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	tert-Butylhydroperoxide	38-43	interleukin 1 beta	Mus musculus	116-124
25880604-7	2015	Additionally, the toxicity induced by tBOOH or FeSO4 exposure was significantly attenuated following treatment with IL-1beta, an effect reversed by concomitant exposure to l-buthionine-S,R-sulfoximine (BSO), which prevented the IL-1beta-mediated rise in GSH production.	tert-Butylhydroperoxide	38-43	interleukin 1 beta	Mus musculus	228-236
26191269-6	2015	CONCLUSION: Rg1 may fight against Sca-1+HSC/HPC senescence induced by t-BHP through regulating SIRT6-NF-kappaB signaling pathway.	tert-Butylhydroperoxide	70-75	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	12-15
26241392-10	2015	The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP.	tert-Butylhydroperoxide	114-118	NAD(P)H quinone dehydrogenase 1	Homo sapiens	4-8
26241392-10	2015	The NQO1, HO-1, and NRF2 were further shown to be required for 4-AC protection of RPE cells from death induced by tBHP.	tert-Butylhydroperoxide	114-118	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
25937383-9	2015	TBOOH diminished AChE gene expression and activity, and caused oxidative stress when administered alone.	tert-Butylhydroperoxide	0-5	acetylcholinesterase	Danio rerio	17-21
26312997-1	2015	We characterized the peroxidase mechanism of recombinant rat brain cytoglobin (Cygb) challenged by hydrogen peroxide, tert-butylhydroperoxide and by cumene hydroperoxide.	tert-Butylhydroperoxide	118-141	cytoglobin	Rattus norvegicus	67-77
26312997-1	2015	We characterized the peroxidase mechanism of recombinant rat brain cytoglobin (Cygb) challenged by hydrogen peroxide, tert-butylhydroperoxide and by cumene hydroperoxide.	tert-Butylhydroperoxide	118-141	cytoglobin	Rattus norvegicus	79-83
25649257-8	2015	The antioxidant N-acetylcysteine (NAC) increased UBE1L protein levels, while pro-oxidants such as hydrogen peroxide and tert-butyl hydroperoxide (tBHP) decreased UBE1L protein levels, indicating that the intracellular redox status is associated with UBE1L expression.	tert-Butylhydroperoxide	120-144	ubiquitin like modifier activating enzyme 7	Homo sapiens	162-167
25649257-8	2015	The antioxidant N-acetylcysteine (NAC) increased UBE1L protein levels, while pro-oxidants such as hydrogen peroxide and tert-butyl hydroperoxide (tBHP) decreased UBE1L protein levels, indicating that the intracellular redox status is associated with UBE1L expression.	tert-Butylhydroperoxide	120-144	ubiquitin like modifier activating enzyme 7	Homo sapiens	162-167
25649257-8	2015	The antioxidant N-acetylcysteine (NAC) increased UBE1L protein levels, while pro-oxidants such as hydrogen peroxide and tert-butyl hydroperoxide (tBHP) decreased UBE1L protein levels, indicating that the intracellular redox status is associated with UBE1L expression.	tert-Butylhydroperoxide	146-150	ubiquitin like modifier activating enzyme 7	Homo sapiens	162-167
25649257-8	2015	The antioxidant N-acetylcysteine (NAC) increased UBE1L protein levels, while pro-oxidants such as hydrogen peroxide and tert-butyl hydroperoxide (tBHP) decreased UBE1L protein levels, indicating that the intracellular redox status is associated with UBE1L expression.	tert-Butylhydroperoxide	146-150	ubiquitin like modifier activating enzyme 7	Homo sapiens	162-167
26205049-3	2015	Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in the livers of t-BHP-treated mice models.	tert-Butylhydroperoxide	140-145	tumor necrosis factor	Mus musculus	93-102
26205049-3	2015	Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in the livers of t-BHP-treated mice models.	tert-Butylhydroperoxide	140-145	interleukin 1 beta	Mus musculus	104-112
26205049-3	2015	Furthermore, licorice extract inhibited the expression levels of pro-inflammatory cytokines (TNF-alpha, IL-1beta and IL-6) in the livers of t-BHP-treated mice models.	tert-Butylhydroperoxide	140-145	interleukin 6	Mus musculus	117-121
25937383-4	2015	The aims of this study were to determine the effects of the antioxidant, vitamin C (VC), the oxidant, t-butyl hydroperoxide (tBOOH) and the organophosphate Chlorpyrifos (CPF), on AChE gene transcription and activity in zebrafish embryos after 72h exposure.	tert-Butylhydroperoxide	102-123	acetylcholinesterase	Danio rerio	179-183
26191269-6	2015	CONCLUSION: Rg1 may fight against Sca-1+HSC/HPC senescence induced by t-BHP through regulating SIRT6-NF-kappaB signaling pathway.	tert-Butylhydroperoxide	70-75	ataxin 1	Homo sapiens	34-39
26191269-6	2015	CONCLUSION: Rg1 may fight against Sca-1+HSC/HPC senescence induced by t-BHP through regulating SIRT6-NF-kappaB signaling pathway.	tert-Butylhydroperoxide	70-75	fucosyltransferase 1 (H blood group)	Homo sapiens	40-43
26191269-6	2015	CONCLUSION: Rg1 may fight against Sca-1+HSC/HPC senescence induced by t-BHP through regulating SIRT6-NF-kappaB signaling pathway.	tert-Butylhydroperoxide	70-75	sirtuin 6	Homo sapiens	95-100
26191269-6	2015	CONCLUSION: Rg1 may fight against Sca-1+HSC/HPC senescence induced by t-BHP through regulating SIRT6-NF-kappaB signaling pathway.	tert-Butylhydroperoxide	70-75	nuclear factor kappa B subunit 1	Homo sapiens	101-110
25533999-4	2015	In vitro, bFGF exerts a protective effect by inhibiting the ER stress response and mitochondrial dysfunction proteins that are induced by tert-Butyl hydroperoxide (TBHP) treatment.	tert-Butylhydroperoxide	138-162	fibroblast growth factor 2	Rattus norvegicus	10-14
25533999-4	2015	In vitro, bFGF exerts a protective effect by inhibiting the ER stress response and mitochondrial dysfunction proteins that are induced by tert-Butyl hydroperoxide (TBHP) treatment.	tert-Butylhydroperoxide	164-168	fibroblast growth factor 2	Rattus norvegicus	10-14
29152617-0	2015	Bacopa monnieri protects SH-SY5Y cells against tert-Butyl hydroperoxide-induced cell death via the ERK and PI3K pathways.	tert-Butylhydroperoxide	47-71	mitogen-activated protein kinase 1	Homo sapiens	99-102
25433273-8	2015	Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased.	tert-Butylhydroperoxide	109-133	AKT serine/threonine kinase 1	Homo sapiens	62-65
25433273-8	2015	Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased.	tert-Butylhydroperoxide	109-133	AKT serine/threonine kinase 1	Homo sapiens	205-208
25433273-8	2015	Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased.	tert-Butylhydroperoxide	135-139	AKT serine/threonine kinase 1	Homo sapiens	62-65
25433273-8	2015	Cell apoptosis was increasing and molecule expression of PI3K/Akt signaling pathway were up-regulated in the tert-Butyl hydroperoxide (tBHP)-injured group, the cell apoptosis and expression levels of PI3K/Akt in Na2SeO3 group were decreased.	tert-Butylhydroperoxide	135-139	AKT serine/threonine kinase 1	Homo sapiens	205-208
25433273-10	2015	Apoptosis induced by tBHP in chondrocyte might be mediated via up-regulation of PI3K/Akt, Na2SeO3 has an effect of anti-apoptosis by down-regulating of PI3K/Akt signaling pathway.	tert-Butylhydroperoxide	21-25	AKT serine/threonine kinase 1	Homo sapiens	85-88
25433273-10	2015	Apoptosis induced by tBHP in chondrocyte might be mediated via up-regulation of PI3K/Akt, Na2SeO3 has an effect of anti-apoptosis by down-regulating of PI3K/Akt signaling pathway.	tert-Butylhydroperoxide	21-25	AKT serine/threonine kinase 1	Homo sapiens	157-160
26084179-7	2015	CONCLUSION: Rg, may inhibit Sca-1 + HSC/HPC senescence induced by t-BHP by regulating SIRT6/NF-KB signal path.	tert-Butylhydroperoxide	66-71	ataxin 1	Homo sapiens	28-33
26084179-7	2015	CONCLUSION: Rg, may inhibit Sca-1 + HSC/HPC senescence induced by t-BHP by regulating SIRT6/NF-KB signal path.	tert-Butylhydroperoxide	66-71	fucosyltransferase 1 (H blood group)	Homo sapiens	36-39
26418250-9	2015	Furthermore, CDK4 inhibition blunted enhanced PS-exposure elicited by tBOOH treatment.	tert-Butylhydroperoxide	70-75	cyclin dependent kinase 4	Homo sapiens	13-17
26138884-7	2015	A 4 hours treatment with either LPS (1microg/ml) or tert-butylhydroperoxide (tBOOH, 5 microM) significantly stimulated Na(+)/H(+) exchanger activity in both genotypes, effects, however, significantly blunted in akt1(-/-) DCs.	tert-Butylhydroperoxide	52-75	thymoma viral proto-oncogene 1	Mus musculus	211-215
26138884-7	2015	A 4 hours treatment with either LPS (1microg/ml) or tert-butylhydroperoxide (tBOOH, 5 microM) significantly stimulated Na(+)/H(+) exchanger activity in both genotypes, effects, however, significantly blunted in akt1(-/-) DCs.	tert-Butylhydroperoxide	77-82	thymoma viral proto-oncogene 1	Mus musculus	211-215
25691908-4	2015	t-BHP injection caused dramatic elevation of serum AST, ALT, and LDH level, while TCW pretreatment notably attenuated these elevations.	tert-Butylhydroperoxide	0-5	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	51-54
25691908-4	2015	t-BHP injection caused dramatic elevation of serum AST, ALT, and LDH level, while TCW pretreatment notably attenuated these elevations.	tert-Butylhydroperoxide	0-5	glutamic pyruvic transaminase, soluble	Mus musculus	56-59
25691908-6	2015	t-BHP injection notably increased malondialdehyde, total reactive oxygen species, and nitric oxide in the liver tissue, while it markedly dropped the antioxidant activities including total antioxidant capacity, total glutathione contents, glutathione peroxidase, superoxide dismutase, and catalase.	tert-Butylhydroperoxide	0-5	catalase	Mus musculus	289-297
25971787-0	2015	Ginsenoside Rg1 relieves tert-Butyl hydroperoxide-induced cell impairment in mouse microglial BV2 cells.	tert-Butylhydroperoxide	25-49	protein phosphatase 1, regulatory subunit 3A	Mus musculus	12-15
25971787-4	2015	The present study aims to investigate the ability of G-Rg1 to decrease the t-BHP-mediated cell damage of BV2 microglial cells.	tert-Butylhydroperoxide	75-80	protein phosphatase 1, regulatory subunit 3A	Mus musculus	55-58
25971787-6	2015	We found that treatment with 50 muM G-Rg1 protected microglial cells against oxidative damage induced by 10 muM t-BHP.	tert-Butylhydroperoxide	112-117	protein phosphatase 1, regulatory subunit 3A	Mus musculus	38-41
26576227-0	2015	Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells.	tert-Butylhydroperoxide	57-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	16-20
25147052-5	2015	Antioxidants MCI-186 and N-acetyl cysteine prevented E-FABP"s induction in expression by PAM-LTx, while tert-butyl hydroperoxide increased ROS and E-FABP expression.	tert-Butylhydroperoxide	104-128	fatty acid binding protein 5	Rattus norvegicus	147-153
29152617-9	2015	Conclusion: These results suggest that BM by activation of ERK/MAPK and PI3K/Akt signaling pathways protects SH-SY5Y cells from TBHP-induced cell death.	tert-Butylhydroperoxide	128-132	mitogen-activated protein kinase 1	Homo sapiens	59-62
29152617-9	2015	Conclusion: These results suggest that BM by activation of ERK/MAPK and PI3K/Akt signaling pathways protects SH-SY5Y cells from TBHP-induced cell death.	tert-Butylhydroperoxide	128-132	mitogen-activated protein kinase 1	Homo sapiens	63-67
25501220-4	2014	The results showed that Rg1 could effectively delay tert-butyl hydroperoxide (t-BHP)-induced senescence and inhibit gene expression in the p16(INK4a)-Rb and p19(Arf)-p53-p21(Cip/Waf1) signaling pathways in HSCs.	tert-Butylhydroperoxide	52-76	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	24-27
25522270-6	2014	Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells.	tert-Butylhydroperoxide	268-273	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	38-64
25522270-6	2014	Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells.	tert-Butylhydroperoxide	268-273	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	66-70
25522270-6	2014	Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells.	tert-Butylhydroperoxide	268-273	superoxide dismutase 2	Homo sapiens	141-145
25522270-6	2014	Moreover, the enzymatic activities of isocitrate dehydrogenase 2 (IDH2), glutathione peroxidase (GSH-Px) and manganese superoxide dismutase (SOD2) as well as deacetylation of SOD2 were increased by RSV pretreatment, suggesting RSV notably enhanced mtROS scavenging in t-BHP-induced endothelial cells.	tert-Butylhydroperoxide	268-273	superoxide dismutase 2	Homo sapiens	175-179
25501220-4	2014	The results showed that Rg1 could effectively delay tert-butyl hydroperoxide (t-BHP)-induced senescence and inhibit gene expression in the p16(INK4a)-Rb and p19(Arf)-p53-p21(Cip/Waf1) signaling pathways in HSCs.	tert-Butylhydroperoxide	78-83	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	24-27
25186470-12	2014	In contrast, the constitutive active form of FOXO3 increased cell viability while inducing GPX-1, Beclin1, and LC3 in response to tBHP.	tert-Butylhydroperoxide	130-134	forkhead box O3	Homo sapiens	45-50
25186470-12	2014	In contrast, the constitutive active form of FOXO3 increased cell viability while inducing GPX-1, Beclin1, and LC3 in response to tBHP.	tert-Butylhydroperoxide	130-134	glutathione peroxidase 1	Homo sapiens	91-96
25186470-11	2014	Knockdown of FOXO1 and FOXO1+3 resulted in significant reductions in levels of glutathione peroxidase 1 (GPX-1), catalase, light chain 3 (LC3), Beclin1, and sirtuin 1 (SIRT-1) proteins following treatment with tBHP.	tert-Butylhydroperoxide	210-214	forkhead box O1	Homo sapiens	13-18
25186470-11	2014	Knockdown of FOXO1 and FOXO1+3 resulted in significant reductions in levels of glutathione peroxidase 1 (GPX-1), catalase, light chain 3 (LC3), Beclin1, and sirtuin 1 (SIRT-1) proteins following treatment with tBHP.	tert-Butylhydroperoxide	210-214	forkhead box O1	Homo sapiens	23-28
25186470-12	2014	In contrast, the constitutive active form of FOXO3 increased cell viability while inducing GPX-1, Beclin1, and LC3 in response to tBHP.	tert-Butylhydroperoxide	130-134	beclin 1	Homo sapiens	98-105
25186470-12	2014	In contrast, the constitutive active form of FOXO3 increased cell viability while inducing GPX-1, Beclin1, and LC3 in response to tBHP.	tert-Butylhydroperoxide	130-134	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	111-114
25379381-0	2014	Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert-butyl hydroperoxide in human red blood cells.	tert-Butylhydroperoxide	60-84	peroxiredoxin 2	Homo sapiens	31-46
25379381-3	2014	The detection of a peak corresponding to Prx2-SO2/3 was clearly observed following treatment of tert-butyl hydroperoxide (t-BHP), but not H2O2, and was found to be dose-dependent.	tert-Butylhydroperoxide	96-120	peroxiredoxin 2	Homo sapiens	41-45
25379381-3	2014	The detection of a peak corresponding to Prx2-SO2/3 was clearly observed following treatment of tert-butyl hydroperoxide (t-BHP), but not H2O2, and was found to be dose-dependent.	tert-Butylhydroperoxide	122-127	peroxiredoxin 2	Homo sapiens	41-45
24705647-0	2014	Acylated and unacylated ghrelin protect MC3T3-E1 cells against tert-butyl hydroperoxide-induced oxidative injury: pharmacological characterization of ghrelin receptor and possible epigenetic involvement.	tert-Butylhydroperoxide	63-87	ghrelin	Mus musculus	24-31
25336922-7	2014	In the hepatoprotective model, apoptotic cell death and nuclear condensation induced by tert-butyl hydroperoxide in HepG2 cells was significantly attenuated by Te-PC and Te-APC.	tert-Butylhydroperoxide	88-112	APC regulator of WNT signaling pathway	Homo sapiens	173-176
25112872-6	2014	Interestingly, we found that in fresh kidney slices, the increased AQP2 S-glutathionylation correlated with tert-butyl hydroperoxide-induced ROS generation.	tert-Butylhydroperoxide	108-132	aquaporin 2	Homo sapiens	67-71
25239548-3	2014	The present study shows that the absence of Rim101 leads to hypersensitivity to oxidants such as t-butyl hydroperoxide and diamide, and also to the prooxidant agent selenite.	tert-Butylhydroperoxide	97-118	alkaline-responsive transcriptional regulator RIM101	Saccharomyces cerevisiae S288C	44-50
24614978-3	2014	We examined in primary cultured rat hepatocytes whether the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) signaling pathway is involved in this process, by using tert-butyl hydroperoxide (tBOOH) as a pro-oxidant, model compound.	tert-Butylhydroperoxide	201-206	calmodulin 1	Rattus norvegicus	77-80
24614978-5	2014	Intracellular Ca2+ sequestration with BAPTA/AM, CaM blockage with W7 or trifluoperazine, and CaMKII inhibition with KN-62 all fully prevented tBOOH-induced MPTP opening and reduced tBOOH-induced lipid peroxidation to a similar extent to CsA, suggesting that Ca2+/CaM/CaMKII signaling pathway fully mediates MPTP-mediated mitochondrial ROS generation.	tert-Butylhydroperoxide	142-147	calmodulin 1	Rattus norvegicus	48-51
24614978-5	2014	Intracellular Ca2+ sequestration with BAPTA/AM, CaM blockage with W7 or trifluoperazine, and CaMKII inhibition with KN-62 all fully prevented tBOOH-induced MPTP opening and reduced tBOOH-induced lipid peroxidation to a similar extent to CsA, suggesting that Ca2+/CaM/CaMKII signaling pathway fully mediates MPTP-mediated mitochondrial ROS generation.	tert-Butylhydroperoxide	142-147	calmodulin 1	Rattus norvegicus	93-96
24614978-6	2014	tBOOH-induced apoptosis, as shown by flow cytometry of annexin V/propidium iodide, mitochondrial release of cytochrome c, activation of caspase-3 and increase in the Bax-to-Bcl-xL ratio, and the Ca2+/CaM/CaMKII signaling antagonists fully prevented these effects.	tert-Butylhydroperoxide	0-5	annexin A5	Rattus norvegicus	55-64
24614978-6	2014	tBOOH-induced apoptosis, as shown by flow cytometry of annexin V/propidium iodide, mitochondrial release of cytochrome c, activation of caspase-3 and increase in the Bax-to-Bcl-xL ratio, and the Ca2+/CaM/CaMKII signaling antagonists fully prevented these effects.	tert-Butylhydroperoxide	0-5	caspase 3	Rattus norvegicus	136-145
24614978-6	2014	tBOOH-induced apoptosis, as shown by flow cytometry of annexin V/propidium iodide, mitochondrial release of cytochrome c, activation of caspase-3 and increase in the Bax-to-Bcl-xL ratio, and the Ca2+/CaM/CaMKII signaling antagonists fully prevented these effects.	tert-Butylhydroperoxide	0-5	BCL2 associated X, apoptosis regulator	Rattus norvegicus	166-169
24614978-6	2014	tBOOH-induced apoptosis, as shown by flow cytometry of annexin V/propidium iodide, mitochondrial release of cytochrome c, activation of caspase-3 and increase in the Bax-to-Bcl-xL ratio, and the Ca2+/CaM/CaMKII signaling antagonists fully prevented these effects.	tert-Butylhydroperoxide	0-5	Bcl2-like 1	Rattus norvegicus	173-179
24614978-6	2014	tBOOH-induced apoptosis, as shown by flow cytometry of annexin V/propidium iodide, mitochondrial release of cytochrome c, activation of caspase-3 and increase in the Bax-to-Bcl-xL ratio, and the Ca2+/CaM/CaMKII signaling antagonists fully prevented these effects.	tert-Butylhydroperoxide	0-5	calmodulin 1	Rattus norvegicus	200-203
24614978-7	2014	Intramitochondrial CaM and CaMKII were partially involved in tBOOH-induced MPTP formation, since W7 and KN-62 both attenuated the tBOOH-induced, MPTP-mediated swelling of isolated mitochondria.	tert-Butylhydroperoxide	61-66	calmodulin 1	Rattus norvegicus	19-22
24614978-7	2014	Intramitochondrial CaM and CaMKII were partially involved in tBOOH-induced MPTP formation, since W7 and KN-62 both attenuated the tBOOH-induced, MPTP-mediated swelling of isolated mitochondria.	tert-Butylhydroperoxide	130-135	calmodulin 1	Rattus norvegicus	19-22
26576227-3	2015	Our results indicated that Lico A significantly inhibited t-BHP-induced cytotoxicity, apoptosis, and reactive oxygen species (ROS) generation and reduced glutathione (GSH) depletion but increased the glutamate-cysteine ligase modifier (GCLM) subunit and the glutamate-cysteine ligase catalytic (GCLC) subunit genes expression.	tert-Butylhydroperoxide	58-63	glutamate-cysteine ligase, modifier subunit	Mus musculus	236-240
26576227-3	2015	Our results indicated that Lico A significantly inhibited t-BHP-induced cytotoxicity, apoptosis, and reactive oxygen species (ROS) generation and reduced glutathione (GSH) depletion but increased the glutamate-cysteine ligase modifier (GCLM) subunit and the glutamate-cysteine ligase catalytic (GCLC) subunit genes expression.	tert-Butylhydroperoxide	58-63	glutamate-cysteine ligase, catalytic subunit	Mus musculus	295-299
26576227-6	2015	Furthermore, Lico A treatment markedly attenuated t-BHP-induced oxidative damage, which was reduced by treatment with PI3K/Akt, ERK, and HO-1 inhibitors.	tert-Butylhydroperoxide	50-55	thymoma viral proto-oncogene 1	Mus musculus	123-126
26576227-6	2015	Furthermore, Lico A treatment markedly attenuated t-BHP-induced oxidative damage, which was reduced by treatment with PI3K/Akt, ERK, and HO-1 inhibitors.	tert-Butylhydroperoxide	50-55	mitogen-activated protein kinase 1	Mus musculus	128-131
26576227-6	2015	Furthermore, Lico A treatment markedly attenuated t-BHP-induced oxidative damage, which was reduced by treatment with PI3K/Akt, ERK, and HO-1 inhibitors.	tert-Butylhydroperoxide	50-55	heme oxygenase 1	Mus musculus	137-141
26576227-7	2015	Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways.	tert-Butylhydroperoxide	55-60	heme oxygenase 1	Mus musculus	96-100
26576227-7	2015	Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways.	tert-Butylhydroperoxide	55-60	thymoma viral proto-oncogene 1	Mus musculus	154-157
26576227-7	2015	Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways.	tert-Butylhydroperoxide	55-60	mitogen-activated protein kinase 1	Mus musculus	162-165
26576227-7	2015	Therefore, Lico A might have a protective role against t-BHP-induced cytotoxicity by modulating HO-1 and by scavenging ROS via the activation of the PI3K/Akt and ERK/Nrf2 signaling pathways.	tert-Butylhydroperoxide	55-60	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170
25244015-5	2014	The activity of alkaline phosphatase (ALP), a marker of the process of osteoblasts differentiation, increased in a time-dependent manner and TBH further increased this activity.	tert-Butylhydroperoxide	141-144	alkaline phosphatase, placental	Homo sapiens	16-36
25244015-5	2014	The activity of alkaline phosphatase (ALP), a marker of the process of osteoblasts differentiation, increased in a time-dependent manner and TBH further increased this activity.	tert-Butylhydroperoxide	141-144	alkaline phosphatase, placental	Homo sapiens	38-41
24853984-4	2014	Hirsutenone prevented the t-BH-induced increase in permeability by inhibiting the reduction in zonula occludens-1 (ZO-1) expression, and rapidly stimulated tyrosine phosphorylation of the epidermal growth factor receptor (EGFR).	tert-Butylhydroperoxide	26-30	tight junction protein 1	Mus musculus	95-113
24853984-4	2014	Hirsutenone prevented the t-BH-induced increase in permeability by inhibiting the reduction in zonula occludens-1 (ZO-1) expression, and rapidly stimulated tyrosine phosphorylation of the epidermal growth factor receptor (EGFR).	tert-Butylhydroperoxide	26-30	tight junction protein 1	Mus musculus	115-119
24853984-4	2014	Hirsutenone prevented the t-BH-induced increase in permeability by inhibiting the reduction in zonula occludens-1 (ZO-1) expression, and rapidly stimulated tyrosine phosphorylation of the epidermal growth factor receptor (EGFR).	tert-Butylhydroperoxide	26-30	epidermal growth factor receptor	Mus musculus	188-220
24853984-4	2014	Hirsutenone prevented the t-BH-induced increase in permeability by inhibiting the reduction in zonula occludens-1 (ZO-1) expression, and rapidly stimulated tyrosine phosphorylation of the epidermal growth factor receptor (EGFR).	tert-Butylhydroperoxide	26-30	epidermal growth factor receptor	Mus musculus	222-226
24705647-2	2014	This study was undertaken to investigate whether ghrelin, previously reported to stimulate osteoblast proliferation, counteracts tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in MC3T3-E1 osteoblastic cells as well as to characterize the ghrelin receptor (GHS-R) involved in such activity.	tert-Butylhydroperoxide	129-153	ghrelin	Mus musculus	49-56
24705647-2	2014	This study was undertaken to investigate whether ghrelin, previously reported to stimulate osteoblast proliferation, counteracts tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in MC3T3-E1 osteoblastic cells as well as to characterize the ghrelin receptor (GHS-R) involved in such activity.	tert-Butylhydroperoxide	155-160	ghrelin	Mus musculus	49-56
24705647-3	2014	Pretreatment with ghrelin (10(-7)-10(-11)M) significantly increased viability and reduced apoptosis of MC3T3-E1 cells cultured with t-BHP (250 muM) for three hours at the low concentration of 10(-9)M as shown by MTT assay and Hoechst-33258 staining.	tert-Butylhydroperoxide	132-137	ghrelin	Mus musculus	18-25
24705647-4	2014	Furthermore, ghrelin prevented t-BHP-induced osteoblastic dysfunction and changes in the cytoskeleton organization evidenced by the staining of the actin fibers with Phalloidin-FITC by reducing reactive oxygen species generation.	tert-Butylhydroperoxide	31-36	ghrelin	Mus musculus	13-20
24705647-6	2014	Accordingly, unacylated ghrelin (DAG), not binding GHS-R1a, displays the same protective actions of ghrelin against t-BHP-induced cytotoxicity.	tert-Butylhydroperoxide	116-121	ghrelin	Mus musculus	24-31
24705647-8	2014	In conclusion, our data demonstrate that ghrelin and DAG promote survival of MC3T3-E1 cell exposed to t-BHP-induced oxidative damage.	tert-Butylhydroperoxide	102-107	ghrelin	Mus musculus	41-48
23918648-2	2014	Forkhead box O (FoxO1) regulates various genes involved in cellular metabolism related to cell death and response to oxidative stress, and Rc is known to prevent FoxO1 phosphorylation by activation of PI3K/Akt and subsequent inhibition of AMP-activated protein kinase (AMPK) in cells exposed to tert-butylhydroperoxide (t-BHP).	tert-Butylhydroperoxide	295-318	forkhead box O1	Homo sapiens	16-21
23918648-2	2014	Forkhead box O (FoxO1) regulates various genes involved in cellular metabolism related to cell death and response to oxidative stress, and Rc is known to prevent FoxO1 phosphorylation by activation of PI3K/Akt and subsequent inhibition of AMP-activated protein kinase (AMPK) in cells exposed to tert-butylhydroperoxide (t-BHP).	tert-Butylhydroperoxide	320-325	forkhead box O1	Homo sapiens	16-21
23918648-3	2014	In the current study, we attempted the mechanism of increased catalase expression by Rc through inhibition of FoxO1 activation resulting from t-BHP-induced production of reactive species (RS).	tert-Butylhydroperoxide	142-147	catalase	Homo sapiens	62-70
23918648-3	2014	In the current study, we attempted the mechanism of increased catalase expression by Rc through inhibition of FoxO1 activation resulting from t-BHP-induced production of reactive species (RS).	tert-Butylhydroperoxide	142-147	forkhead box O1	Homo sapiens	110-115
24486304-4	2014	KEY FINDINGS: When tBHP was used to induce lipid peroxidation, lycopene was the most efficient carotenoid (IC50=2.2 +- 0.4 muM), while lutein was the most efficient (IC50=2.5 +- 0.7 muM) when peroxyl radicals (ROO) were generated by AAPH.	tert-Butylhydroperoxide	19-23	latexin	Homo sapiens	123-126
24582277-6	2014	Among the tested compounds, 6"-O-caffeoylacteoside exhibited the most potent cytoprotective activity with an IC50 value of 0.8+-0.1 muM against t-BHP-induced toxicity.	tert-Butylhydroperoxide	144-149	latexin	Homo sapiens	132-135
24857917-0	2014	The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.	tert-Butylhydroperoxide	48-72	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
24857917-0	2014	The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.	tert-Butylhydroperoxide	48-72	mitogen-activated protein kinase 8	Homo sapiens	117-120
24857917-0	2014	The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.	tert-Butylhydroperoxide	48-72	mitogen-activated protein kinase 1	Homo sapiens	121-124
24857917-0	2014	The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.	tert-Butylhydroperoxide	48-72	mitogen-activated protein kinase 3	Homo sapiens	125-129
24857917-0	2014	The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression.	tert-Butylhydroperoxide	48-72	heme oxygenase 1	Homo sapiens	139-155
24497499-11	2014	Treatment of chondrocytes with tBHP to induce oxidative stress increased Nupr1 mRNA expression by >2-fold; treatment with thapsigargin to induce endoplasmic reticulum stress did not produce a similar effect.	tert-Butylhydroperoxide	31-35	nuclear protein 1, transcriptional regulator	Homo sapiens	73-78
24434121-9	2014	All forms of Sepp1 except Sepp1(U40S), which contains serine in place of the selenocysteine, were TrxR1 substrates, catalyzing NADPH oxidation when coupled with H2O2 or tert-butylhydroperoxide as the terminal electron acceptor.	tert-Butylhydroperoxide	169-192	selenoprotein P	Mus musculus	13-18
24741394-5	2014	Moreover, TBHP-induced oxidative stress resulted in a transient ERK1/2 activation and a sustained increase of JNK1/2 activation.	tert-Butylhydroperoxide	10-14	mitogen-activated protein kinase 3	Homo sapiens	64-70
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	135-159	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	135-159	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	27-30
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	135-159	NFE2 like bZIP transcription factor 2	Rattus norvegicus	53-57
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	161-165	AKT serine/threonine kinase 1	Rattus norvegicus	19-22
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	161-165	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	27-30
24675471-7	2014	The involvement of Akt and Fyn kinase in influencing Nrf2 signaling was further confirmed in oxidatively stressed hepatocytes by using tert-butyl hydroperoxide (tBHP).	tert-Butylhydroperoxide	161-165	NFE2 like bZIP transcription factor 2	Rattus norvegicus	53-57
24675471-8	2014	tBHP-induced decrease in Nrf2 levels was associated with enhanced Fyn kinase phosphorylation, Fyn kinase nuclear translocation and decreased levels of phosphorylated GSK3beta(Ser9) in a time-dependent manner.	tert-Butylhydroperoxide	0-4	NFE2 like bZIP transcription factor 2	Rattus norvegicus	25-29
24675471-8	2014	tBHP-induced decrease in Nrf2 levels was associated with enhanced Fyn kinase phosphorylation, Fyn kinase nuclear translocation and decreased levels of phosphorylated GSK3beta(Ser9) in a time-dependent manner.	tert-Butylhydroperoxide	0-4	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	66-69
24675471-8	2014	tBHP-induced decrease in Nrf2 levels was associated with enhanced Fyn kinase phosphorylation, Fyn kinase nuclear translocation and decreased levels of phosphorylated GSK3beta(Ser9) in a time-dependent manner.	tert-Butylhydroperoxide	0-4	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	94-97
24675471-8	2014	tBHP-induced decrease in Nrf2 levels was associated with enhanced Fyn kinase phosphorylation, Fyn kinase nuclear translocation and decreased levels of phosphorylated GSK3beta(Ser9) in a time-dependent manner.	tert-Butylhydroperoxide	0-4	glycogen synthase kinase 3 beta	Rattus norvegicus	166-174
24675471-9	2014	Interestingly, tBHP induced site-specific deactivation of Akt as only Akt(Ser473) phosphorylation was observed to be affected.	tert-Butylhydroperoxide	15-19	AKT serine/threonine kinase 1	Rattus norvegicus	58-61
24675471-10	2014	Further, protein expression as well as nuclear localization of PHLPP2, a phosphatase specific for Akt(Ser473), was found to be significantly enhanced in tBHP-stressed hepatocytes.	tert-Butylhydroperoxide	153-157	PH domain and leucine rich repeat protein phosphatase 2	Rattus norvegicus	63-69
24675471-10	2014	Further, protein expression as well as nuclear localization of PHLPP2, a phosphatase specific for Akt(Ser473), was found to be significantly enhanced in tBHP-stressed hepatocytes.	tert-Butylhydroperoxide	153-157	AKT serine/threonine kinase 1	Rattus norvegicus	98-101
24675471-11	2014	Silencing of PHLPP2 not only resulted in considerable restoration of Nrf2 signaling, enhanced Nrf2-ARE binding and reduced Nrf2 ubiquitination but also significantly suppressed tBHP-induced ROS generation and alterations in mitochondrial permeability.	tert-Butylhydroperoxide	177-181	PH domain and leucine rich repeat protein phosphatase 2	Rattus norvegicus	13-19
24486304-4	2014	KEY FINDINGS: When tBHP was used to induce lipid peroxidation, lycopene was the most efficient carotenoid (IC50=2.2 +- 0.4 muM), while lutein was the most efficient (IC50=2.5 +- 0.7 muM) when peroxyl radicals (ROO) were generated by AAPH.	tert-Butylhydroperoxide	19-23	latexin	Homo sapiens	182-185
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	58-82	heme oxygenase 1	Mus musculus	52-56
24662068-4	2014	Here we report that Rb1 exhibits potent neuroprotective effects against oxidative injury induced by tert-butylhydroperoxide (t-BHP).	tert-Butylhydroperoxide	100-123	RB transcriptional corepressor 1	Rattus norvegicus	20-23
24662068-4	2014	Here we report that Rb1 exhibits potent neuroprotective effects against oxidative injury induced by tert-butylhydroperoxide (t-BHP).	tert-Butylhydroperoxide	125-130	RB transcriptional corepressor 1	Rattus norvegicus	20-23
24662068-5	2014	Lactate dehydrogenase (LDH) assay demonstrated that incubation with 300 microm t-BHP for 2.5 h led to a significant cell loss of cultured rat embryonic cortex-derived neural progenitor cells (NPCs) and the cell viability was pronouncedly increased by 24 h pretreatment of 10 microm Rb1.	tert-Butylhydroperoxide	79-84	RB transcriptional corepressor 1	Rattus norvegicus	282-285
24662068-6	2014	TUNEL staining further confirmed that pretreatment of Rb1 significantly reduced the cell apoptosis in t-BHP-induced oxidative injury.	tert-Butylhydroperoxide	102-107	RB transcriptional corepressor 1	Rattus norvegicus	54-57
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	58-82	heme oxygenase 1	Mus musculus	248-252
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	84-89	heme oxygenase 1	Mus musculus	52-56
24361407-6	2014	In order to identify the antioxidation potential by HO-1, tert-butyl hydroperoxide (t-BHP)-induced oxidative damage was applied and ameliorated by luteolin and the luteolin-7-O-glucoside treatment in a dose dependent manner, which was confirmed by HO-1 selective inhibitor and inducer, tin protoporphyrin (SnPP) and cobalt protoporphyrin (CoPP), respectively.	tert-Butylhydroperoxide	84-89	heme oxygenase 1	Mus musculus	248-252
24382579-2	2014	The reaction involves a radical process and one C(sp(2))-C(sp(2)) and two C(sp(2))-C(sp(3)) bonds are formed simultaneously in one pot by using PivOH and TBHP.	tert-Butylhydroperoxide	154-158	regulator of calcineurin 2	Homo sapiens	48-55
24394546-5	2014	t-BHP dose-dependent induction of cell apoptosis and stained liver sections relieved the acute rat liver injury were accompanied by sustained phosphorylation of JNK1/2 and p65.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase 8	Homo sapiens	161-167
24394546-5	2014	t-BHP dose-dependent induction of cell apoptosis and stained liver sections relieved the acute rat liver injury were accompanied by sustained phosphorylation of JNK1/2 and p65.	tert-Butylhydroperoxide	0-5	synaptotagmin 1	Rattus norvegicus	172-175
24394546-7	2014	Furthermore, we demonstrated that t-BHP induced human Chang liver cell viability and apoptosis properties by up-regulating the levels of ETFA (electron transfer flavoprotein subunit alpha).	tert-Butylhydroperoxide	34-39	electron transfer flavoprotein subunit alpha	Homo sapiens	137-141
24394546-8	2014	This study demonstrated that there was an increase in the cellular levels of ETFA in the t-BHP induction in viability and apoptosis via the activation of JNK1/2 and NFkappaB signaling modules.	tert-Butylhydroperoxide	89-94	electron transfer flavoprotein subunit alpha	Homo sapiens	77-81
24394546-8	2014	This study demonstrated that there was an increase in the cellular levels of ETFA in the t-BHP induction in viability and apoptosis via the activation of JNK1/2 and NFkappaB signaling modules.	tert-Butylhydroperoxide	89-94	mitogen-activated protein kinase 8	Homo sapiens	154-160
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	synuclein alpha	Homo sapiens	0-3
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	electron transfer flavoprotein subunit alpha	Homo sapiens	29-33
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	electron transfer flavoprotein subunit alpha	Homo sapiens	74-78
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	DNA damage inducible transcript 3	Homo sapiens	83-87
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	103-113
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	TNF receptor associated factor 2	Homo sapiens	114-119
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	mitogen-activated protein kinase 8	Homo sapiens	153-159
24394546-9	2014	NAC administration and shRNA ETFA conferred resistance to t-BHP-increased ETFA and CHOP expression via IRE1-alpha/TRAF2 complex formation, activation of JNK1/2 and p50.	tert-Butylhydroperoxide	58-63	nuclear factor kappa B subunit 1	Homo sapiens	164-167
24394546-10	2014	We concluded that the mechanism of t-BHP-induced an apoptosis cascade and endoplasmic reticulum stress in hepatocyte cells by up-regulation of ETFA, providing a new mechanism for liver injury.	tert-Butylhydroperoxide	35-40	electron transfer flavoprotein subunit alpha	Homo sapiens	143-147
24484587-7	2014	Remarkably, we found that 60% of the DUX4 toxicity inhibitors that we identified also protected cells from tert-butyl hydrogen peroxide, an oxidative stress-inducing compound.	tert-Butylhydroperoxide	107-135	double homeobox 4	Homo sapiens	37-41
23957350-8	2014	Moreover, mdt-15 is essential for the transcriptional response to and survival on the organic peroxide tert-butyl-hydroperoxide (tBOOH), a largely SKN-1-independent response.	tert-Butylhydroperoxide	103-127	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	10-16
23957350-8	2014	Moreover, mdt-15 is essential for the transcriptional response to and survival on the organic peroxide tert-butyl-hydroperoxide (tBOOH), a largely SKN-1-independent response.	tert-Butylhydroperoxide	103-127	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	147-152
23957350-8	2014	Moreover, mdt-15 is essential for the transcriptional response to and survival on the organic peroxide tert-butyl-hydroperoxide (tBOOH), a largely SKN-1-independent response.	tert-Butylhydroperoxide	129-134	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	10-16
23957350-8	2014	Moreover, mdt-15 is essential for the transcriptional response to and survival on the organic peroxide tert-butyl-hydroperoxide (tBOOH), a largely SKN-1-independent response.	tert-Butylhydroperoxide	129-134	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	147-152
23957350-9	2014	The MDT-15 interacting nuclear hormone receptor, NHR-64, is specifically required for tBOOH but not arsenite resistance, but NHR-64 is dispensable for the transcriptional response to tBOOH.	tert-Butylhydroperoxide	86-91	Mediator of RNA polymerase II transcription subunit 15	Caenorhabditis elegans	4-10
23957350-9	2014	The MDT-15 interacting nuclear hormone receptor, NHR-64, is specifically required for tBOOH but not arsenite resistance, but NHR-64 is dispensable for the transcriptional response to tBOOH.	tert-Butylhydroperoxide	86-91	Nuclear hormone receptor family member nhr-64	Caenorhabditis elegans	49-55
24307565-3	2014	We found that pretreatment with leukemia inhibitory factor (LIF) preserves astrocytes exposed to toxic levels of t-BHP by inhibiting an increase in intracellular ROS following t-BHP treatment.	tert-Butylhydroperoxide	113-118	LIF interleukin 6 family cytokine	Homo sapiens	32-58
24307565-3	2014	We found that pretreatment with leukemia inhibitory factor (LIF) preserves astrocytes exposed to toxic levels of t-BHP by inhibiting an increase in intracellular ROS following t-BHP treatment.	tert-Butylhydroperoxide	113-118	LIF interleukin 6 family cytokine	Homo sapiens	60-63
24307565-3	2014	We found that pretreatment with leukemia inhibitory factor (LIF) preserves astrocytes exposed to toxic levels of t-BHP by inhibiting an increase in intracellular ROS following t-BHP treatment.	tert-Butylhydroperoxide	176-181	LIF interleukin 6 family cytokine	Homo sapiens	32-58
24307565-3	2014	We found that pretreatment with leukemia inhibitory factor (LIF) preserves astrocytes exposed to toxic levels of t-BHP by inhibiting an increase in intracellular ROS following t-BHP treatment.	tert-Butylhydroperoxide	176-181	LIF interleukin 6 family cytokine	Homo sapiens	60-63
24070586-9	2013	In addition, JNK activation induced by phorone and tert-butylhydroperoxide in vivo was inhibited by 2-APB.	tert-Butylhydroperoxide	51-74	mitogen-activated protein kinase 8	Mus musculus	13-16
24662601-4	2014	Treatment of tBHP resulted in apoptotic cell death as assessed by TUNEL assay and the expression of apoptosis regulator proteins, Bcl-2 family, caspases and cytochrome c.	tert-Butylhydroperoxide	13-17	BCL2 apoptosis regulator	Homo sapiens	130-135
24662601-4	2014	Treatment of tBHP resulted in apoptotic cell death as assessed by TUNEL assay and the expression of apoptosis regulator proteins, Bcl-2 family, caspases and cytochrome c.	tert-Butylhydroperoxide	13-17	cytochrome c, somatic	Homo sapiens	157-169
24211276-10	2014	Finally, we showed that Nrf2 deficiency blocked the ability of isorhamnetin to protect cells from injury induced by t-BHP.	tert-Butylhydroperoxide	116-121	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
24186494-7	2014	In cultured MIO-M1 cells, NRF2 inhibition significantly decreased antioxidant gene expression and exacerbated tert-butyl hydroperoxide- and hydrogen peroxide-induced oxidative stress.	tert-Butylhydroperoxide	110-134	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
24231470-6	2014	The down-regulated Bcl-2 mRNA level and up-regulated Bax, Caspase-9, and Caspase-3 mRNA expression induced by H2O2 or t-BHP could be restored by EPA-enriched PL pretreatment.	tert-Butylhydroperoxide	118-123	BCL2, apoptosis regulator	Rattus norvegicus	19-24
24231470-6	2014	The down-regulated Bcl-2 mRNA level and up-regulated Bax, Caspase-9, and Caspase-3 mRNA expression induced by H2O2 or t-BHP could be restored by EPA-enriched PL pretreatment.	tert-Butylhydroperoxide	118-123	BCL2 associated X, apoptosis regulator	Rattus norvegicus	53-56
24231470-6	2014	The down-regulated Bcl-2 mRNA level and up-regulated Bax, Caspase-9, and Caspase-3 mRNA expression induced by H2O2 or t-BHP could be restored by EPA-enriched PL pretreatment.	tert-Butylhydroperoxide	118-123	caspase 9	Rattus norvegicus	58-67
24231470-6	2014	The down-regulated Bcl-2 mRNA level and up-regulated Bax, Caspase-9, and Caspase-3 mRNA expression induced by H2O2 or t-BHP could be restored by EPA-enriched PL pretreatment.	tert-Butylhydroperoxide	118-123	caspase 3	Rattus norvegicus	73-82
24116746-6	2013	Ru2(OAc)4Cl may be kinetically saturated with TBHP; however, Ru2(esp)2Cl does not display saturation kinetics.	tert-Butylhydroperoxide	46-50	doublecortin domain containing 2	Homo sapiens	0-3
23495831-8	2013	In contrast, administration of the ROS donor tert-butyl hydroperoxide induced a prolonged pain behavior in naive Sesn2(-/-) mice.	tert-Butylhydroperoxide	45-69	sestrin 2	Homo sapiens	113-118
24116746-9	2013	Density functional theory (DFT) calculation for the model compound Ru2(OAc)4Cl TBHP, with TBHP on the open axial site, revealed elongation of the O-O bond of TBHP upon coordination.	tert-Butylhydroperoxide	79-83	doublecortin domain containing 2	Homo sapiens	67-78
24116746-9	2013	Density functional theory (DFT) calculation for the model compound Ru2(OAc)4Cl TBHP, with TBHP on the open axial site, revealed elongation of the O-O bond of TBHP upon coordination.	tert-Butylhydroperoxide	90-94	doublecortin domain containing 2	Homo sapiens	67-78
24116746-9	2013	Density functional theory (DFT) calculation for the model compound Ru2(OAc)4Cl TBHP, with TBHP on the open axial site, revealed elongation of the O-O bond of TBHP upon coordination.	tert-Butylhydroperoxide	90-94	doublecortin domain containing 2	Homo sapiens	67-78
23776393-7	2013	Phosphorylated extracellular signal-regulated kinase (pERK) was upregulated by TBHP and downregulated by X/XO.	tert-Butylhydroperoxide	79-83	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	54-58
24511683-5	2013	A significant correlation was observed between hepcidin concentration after treatment and t-BHP-induced hemolysis before treatment.	tert-Butylhydroperoxide	90-95	hepcidin antimicrobial peptide	Homo sapiens	47-55
24055470-2	2013	When mouse neuroblastoma, Neuro2A cells were exposed to tert-butyl hydroperoxide after treatment with polysulfide, a significant decline in cell toxicity was observed.	tert-Butylhydroperoxide	56-80	Rho guanine nucleotide exchange factor (GEF) 16	Mus musculus	11-24
24298298-7	2013	nrf genes were induced by the oxidant tert-butylhydroperoxide, and some of this response was regulated through family members Nrf2a and Nrf2b.	tert-Butylhydroperoxide	38-61	nuclear respiratory factor 1	Danio rerio	0-3
24298298-7	2013	nrf genes were induced by the oxidant tert-butylhydroperoxide, and some of this response was regulated through family members Nrf2a and Nrf2b.	tert-Butylhydroperoxide	38-61	nfe2 like bZIP transcription factor 2a	Danio rerio	126-131
24298298-7	2013	nrf genes were induced by the oxidant tert-butylhydroperoxide, and some of this response was regulated through family members Nrf2a and Nrf2b.	tert-Butylhydroperoxide	38-61	nfe2 like bZIP transcription factor 2b	Danio rerio	136-141
24098330-4	2013	The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide.	tert-Butylhydroperoxide	70-91	thioredoxin	Homo sapiens	127-138
24098330-4	2013	The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide.	tert-Butylhydroperoxide	70-91	thioredoxin	Homo sapiens	140-143
24098330-4	2013	The purified His-tag fusion proteins of W69 and W106 reduced H2O2 and t-butyl hydroperoxide (t-BHP) using glutathione (GSH) or thioredoxin (Trx) as an electron donor in vitro, showing their peroxidase activity toward H2O2 and toxic organic hydroperoxide.	tert-Butylhydroperoxide	93-98	thioredoxin	Homo sapiens	140-143
22964634-6	2013	Selenium-dependent GPX activity correlated with endogenous GPX1 expression and overexpression of exogenous GPX1 induced GPX activity and significantly increased resistance to tert-butyl hydroperoxide.	tert-Butylhydroperoxide	175-199	glutathione peroxidase 1	Homo sapiens	107-111
23583701-6	2013	Results revealed that an oxidative stress-induced PTK/PTP imbalance led to phosphorylation of PP2Ac, following exposures to t-BHP, AAPH, and Na3VO4 in HEK293T cells.	tert-Butylhydroperoxide	124-129	protein tyrosine kinase 2 beta	Homo sapiens	50-53
23583701-6	2013	Results revealed that an oxidative stress-induced PTK/PTP imbalance led to phosphorylation of PP2Ac, following exposures to t-BHP, AAPH, and Na3VO4 in HEK293T cells.	tert-Butylhydroperoxide	124-129	protein tyrosine phosphatase receptor type U	Homo sapiens	54-57
23583701-6	2013	Results revealed that an oxidative stress-induced PTK/PTP imbalance led to phosphorylation of PP2Ac, following exposures to t-BHP, AAPH, and Na3VO4 in HEK293T cells.	tert-Butylhydroperoxide	124-129	protein phosphatase 2 catalytic subunit alpha	Homo sapiens	94-99
23776393-5	2013	The hydrogen peroxide donor, tert-butyl hydroperoxide (TBHP), upregulated KCa3.1 expression, while the superoxide donors, xanthine/xanthine oxidase mixture (X/XO) and lysopho-sphatidylcholine (LPC), downregulated its expression, in a concentration-dependent manner.	tert-Butylhydroperoxide	29-53	potassium calcium-activated channel subfamily N member 4	Homo sapiens	74-80
23776393-5	2013	The hydrogen peroxide donor, tert-butyl hydroperoxide (TBHP), upregulated KCa3.1 expression, while the superoxide donors, xanthine/xanthine oxidase mixture (X/XO) and lysopho-sphatidylcholine (LPC), downregulated its expression, in a concentration-dependent manner.	tert-Butylhydroperoxide	55-59	potassium calcium-activated channel subfamily N member 4	Homo sapiens	74-80
23984931-3	2013	In our study, tert-butyl hydroperoxide (tBHP)-induced cells accelerated HMC senescence, as judged by increased senescence-associated beta-galactosidase stained positive cells, morphological changes, and G0-G1 cell cycle arrest.	tert-Butylhydroperoxide	14-38	galactosidase beta 1	Homo sapiens	133-151
23984931-3	2013	In our study, tert-butyl hydroperoxide (tBHP)-induced cells accelerated HMC senescence, as judged by increased senescence-associated beta-galactosidase stained positive cells, morphological changes, and G0-G1 cell cycle arrest.	tert-Butylhydroperoxide	40-44	galactosidase beta 1	Homo sapiens	133-151
23984931-4	2013	STAT1 and STAT3 activity were increased in tBHP-induced cells.	tert-Butylhydroperoxide	43-47	signal transducer and activator of transcription 1	Homo sapiens	0-5
23984931-4	2013	STAT1 and STAT3 activity were increased in tBHP-induced cells.	tert-Butylhydroperoxide	43-47	signal transducer and activator of transcription 3	Homo sapiens	10-15
23984931-5	2013	After tBHP treatment, Bcl-2 protein expression decreased and Bax protein expression increased.	tert-Butylhydroperoxide	6-10	BCL2 apoptosis regulator	Homo sapiens	22-27
23984931-5	2013	After tBHP treatment, Bcl-2 protein expression decreased and Bax protein expression increased.	tert-Butylhydroperoxide	6-10	BCL2 associated X, apoptosis regulator	Homo sapiens	61-64
23984931-8	2013	Our results indicated that the JAK2-STAT pathway might mediate tBHP-induced HMC senescence through the Bcl-2-Bax pathway, and that probucol could attenuate HMC senescence by regulating STATs.	tert-Butylhydroperoxide	63-67	Janus kinase 2	Homo sapiens	31-35
23984931-8	2013	Our results indicated that the JAK2-STAT pathway might mediate tBHP-induced HMC senescence through the Bcl-2-Bax pathway, and that probucol could attenuate HMC senescence by regulating STATs.	tert-Butylhydroperoxide	63-67	BCL2 apoptosis regulator	Homo sapiens	103-108
23984931-8	2013	Our results indicated that the JAK2-STAT pathway might mediate tBHP-induced HMC senescence through the Bcl-2-Bax pathway, and that probucol could attenuate HMC senescence by regulating STATs.	tert-Butylhydroperoxide	63-67	BCL2 associated X, apoptosis regulator	Homo sapiens	109-112
23936162-2	2013	In our recent study, a novel nitrone derivative of apocynin, AN-1, demonstrated potent inhibition to oxidative injury and to high expression of gp91(phox) subunit of NADPH-oxidase induced by tert-butyl hydroperoxide (t-BHP) in RAW 264.7 macrophage cells, and displayed promising preclinical protective effect against lipopolysaccharide (LPS)-induced acute lung injury in rats.	tert-Butylhydroperoxide	191-215	paired Ig-like receptor B	Mus musculus	144-148
23936162-2	2013	In our recent study, a novel nitrone derivative of apocynin, AN-1, demonstrated potent inhibition to oxidative injury and to high expression of gp91(phox) subunit of NADPH-oxidase induced by tert-butyl hydroperoxide (t-BHP) in RAW 264.7 macrophage cells, and displayed promising preclinical protective effect against lipopolysaccharide (LPS)-induced acute lung injury in rats.	tert-Butylhydroperoxide	217-222	paired Ig-like receptor B	Mus musculus	144-148
23922950-9	2013	We screened each target against H2O2, tert-butyl hydroperoxide, and 4-hydroxynonenal and subsequently identified three enzymes-catalase, prostaglandin reductase-1, and peroxiredoxin-6-that are critical for Nrf2-mediated protection in astrocytes.	tert-Butylhydroperoxide	38-62	prostaglandin reductase 1	Homo sapiens	137-162
23922950-9	2013	We screened each target against H2O2, tert-butyl hydroperoxide, and 4-hydroxynonenal and subsequently identified three enzymes-catalase, prostaglandin reductase-1, and peroxiredoxin-6-that are critical for Nrf2-mediated protection in astrocytes.	tert-Butylhydroperoxide	38-62	peroxiredoxin 6	Homo sapiens	168-183
23922950-9	2013	We screened each target against H2O2, tert-butyl hydroperoxide, and 4-hydroxynonenal and subsequently identified three enzymes-catalase, prostaglandin reductase-1, and peroxiredoxin-6-that are critical for Nrf2-mediated protection in astrocytes.	tert-Butylhydroperoxide	38-62	NFE2 like bZIP transcription factor 2	Homo sapiens	206-210
23776393-9	2013	Furthermore, KCa3.1 current, which was activated by clamping cells with 1 microM Ca(2+) and applying the KCa3.1 activator 1-ethyl-2-benzimidazolinone, was further augmented by TBHP, and inhibited by X/XO.	tert-Butylhydroperoxide	176-180	potassium calcium-activated channel subfamily N member 4	Homo sapiens	13-19
23776393-9	2013	Furthermore, KCa3.1 current, which was activated by clamping cells with 1 microM Ca(2+) and applying the KCa3.1 activator 1-ethyl-2-benzimidazolinone, was further augmented by TBHP, and inhibited by X/XO.	tert-Butylhydroperoxide	176-180	potassium calcium-activated channel subfamily N member 4	Homo sapiens	105-111
23507752-5	2013	The applicability of the proposed approach has been verified by the assessment of changes in isoprostane levels in plasma samples derived from mice exposed to tert-butyl hydroperoxide (TBHP), a model inducer of oxidative stress, or to antitumor drug doxorubicin (DOX) known for potent stimulation of redox cycling.	tert-Butylhydroperoxide	185-189	telomerase reverse transcriptase	Mus musculus	159-163
23200001-9	2013	Moreover, TBHP treatment increased the activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD).	tert-Butylhydroperoxide	10-14	catalase	Homo sapiens	83-91
23200001-9	2013	Moreover, TBHP treatment increased the activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD).	tert-Butylhydroperoxide	10-14	catalase	Homo sapiens	93-96
23200001-9	2013	Moreover, TBHP treatment increased the activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD).	tert-Butylhydroperoxide	10-14	superoxide dismutase 1	Homo sapiens	103-123
23200001-9	2013	Moreover, TBHP treatment increased the activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD).	tert-Butylhydroperoxide	10-14	superoxide dismutase 1	Homo sapiens	125-128
23261940-9	2013	In contrast, plasma from PE did not generate hydrogen peroxide, and the hydrogen peroxide donor tert-butylhydroperoxide induced KCa3.1 upregulation.	tert-Butylhydroperoxide	96-119	potassium calcium-activated channel subfamily N member 4	Homo sapiens	128-134
23350672-4	2013	Heme-hemopexin is relatively resistant to damage by ROS and retains its ability to induce the cytoprotective HO1 after exposure to tert-butylhydroperoxide, although induction is impaired, but not eliminated, by exposure to high concentrations of H(2)O(2) in vitro.	tert-Butylhydroperoxide	131-154	hemopexin	Homo sapiens	5-14
23350672-4	2013	Heme-hemopexin is relatively resistant to damage by ROS and retains its ability to induce the cytoprotective HO1 after exposure to tert-butylhydroperoxide, although induction is impaired, but not eliminated, by exposure to high concentrations of H(2)O(2) in vitro.	tert-Butylhydroperoxide	131-154	heme oxygenase 1	Homo sapiens	109-112
22980779-4	2012	The protective effect of WESP and their bioactive compounds in 0.2mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation.	tert-Butylhydroperoxide	69-74	BCL2 apoptosis regulator	Homo sapiens	277-282
23164639-6	2013	Interaction between piGST and Prdx6, evaluated by the Duolink Proximity Ligation Assay, was minimal under basal conditions but increased dramatically following treatment of cells with the oxidant, tert-butyl hydroperoxide.	tert-Butylhydroperoxide	197-221	peroxiredoxin 6	Homo sapiens	30-35
23107872-9	2013	Ca(2+) ionophore ionomycin (1 muM) and oxidative stress (30-minute exposure to 0.3 mM of tert-butylhydroperoxide) increased annexin-V-binding, effects again blunted by 30 muM of probucol.	tert-Butylhydroperoxide	89-112	latexin	Homo sapiens	30-33
23107872-9	2013	Ca(2+) ionophore ionomycin (1 muM) and oxidative stress (30-minute exposure to 0.3 mM of tert-butylhydroperoxide) increased annexin-V-binding, effects again blunted by 30 muM of probucol.	tert-Butylhydroperoxide	89-112	annexin A5	Homo sapiens	124-133
23107872-9	2013	Ca(2+) ionophore ionomycin (1 muM) and oxidative stress (30-minute exposure to 0.3 mM of tert-butylhydroperoxide) increased annexin-V-binding, effects again blunted by 30 muM of probucol.	tert-Butylhydroperoxide	89-112	latexin	Homo sapiens	171-174
23201076-4	2013	We thus conclude that tBOOH strongly inhibits Na(+)-coupled monocarboxylate cotransporter 1 (SMCT1)-mediated, but not H(+)-coupled monocarboxylate transporter (MCT1)-mediated butyrate uptake; moreover, it increases uptake and efflux of butyrate by passive diffusion.	tert-Butylhydroperoxide	22-27	solute carrier family 16 member 1	Rattus norvegicus	94-98
23257616-6	2013	RESULTS: hRPE cells exposed to a regimen of TBHP for 5 days upregulate expression of several molecules identified in drusen, including molecular chaperones and pro-angiogenic factors.	tert-Butylhydroperoxide	44-48	ribulose-5-phosphate-3-epimerase	Homo sapiens	9-13
23257616-14	2013	This adult stem cell-based system using chronic TBHP treatment of hRPE represents a novel in vitro model useful for the study of drusen formation and dry AMD pathophysiology.	tert-Butylhydroperoxide	48-52	ribulose-5-phosphate-3-epimerase	Homo sapiens	66-70
22864849-5	2013	Cellular reactive oxygen species production induced by tBHP was attenuated by pretreatment with chrysin, apigenin, and luteolin (P < .05), and this protection was reversed by the GCL inhibitor l-buthionine-S-sulfoximine and the HO-1 inhibitor zinc protoporphyrin.	tert-Butylhydroperoxide	55-59	heme oxygenase 1	Rattus norvegicus	231-235
22864849-8	2013	Taken together, these results suggest that chrysin, apigenin, and luteolin inhibit tBHP-induced oxidative stress by up-regulating HO-1, GCLC, and GCLM gene transcription via the ERK2/Nrf2/ARE signaling pathways in rat primary hepatocytes.	tert-Butylhydroperoxide	83-87	heme oxygenase 1	Rattus norvegicus	130-134
22864849-8	2013	Taken together, these results suggest that chrysin, apigenin, and luteolin inhibit tBHP-induced oxidative stress by up-regulating HO-1, GCLC, and GCLM gene transcription via the ERK2/Nrf2/ARE signaling pathways in rat primary hepatocytes.	tert-Butylhydroperoxide	83-87	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	136-140
22864849-8	2013	Taken together, these results suggest that chrysin, apigenin, and luteolin inhibit tBHP-induced oxidative stress by up-regulating HO-1, GCLC, and GCLM gene transcription via the ERK2/Nrf2/ARE signaling pathways in rat primary hepatocytes.	tert-Butylhydroperoxide	83-87	glutamate cysteine ligase, modifier subunit	Rattus norvegicus	146-150
22864849-8	2013	Taken together, these results suggest that chrysin, apigenin, and luteolin inhibit tBHP-induced oxidative stress by up-regulating HO-1, GCLC, and GCLM gene transcription via the ERK2/Nrf2/ARE signaling pathways in rat primary hepatocytes.	tert-Butylhydroperoxide	83-87	mitogen activated protein kinase 1	Rattus norvegicus	178-182
22864849-8	2013	Taken together, these results suggest that chrysin, apigenin, and luteolin inhibit tBHP-induced oxidative stress by up-regulating HO-1, GCLC, and GCLM gene transcription via the ERK2/Nrf2/ARE signaling pathways in rat primary hepatocytes.	tert-Butylhydroperoxide	83-87	NFE2 like bZIP transcription factor 2	Rattus norvegicus	183-187
23984319-0	2013	The effect of Msh2 knockdown on toxicity induced by tert-butyl-hydroperoxide, potassium bromate, and hydrogen peroxide in base excision repair proficient and deficient cells.	tert-Butylhydroperoxide	52-76	mutS homolog 2	Mus musculus	14-18
24078830-0	2013	Bisdemethoxycurcumin Increases Sirt1 to Antagonize t-BHP-Induced Premature Senescence in WI38 Fibroblast Cells.	tert-Butylhydroperoxide	51-56	sirtuin 1	Homo sapiens	31-36
24078830-7	2013	Moreover, downregulating Sirt1 by the pharmacological inhibitor nicotianamine or small interfering RNA blocked BDMC-mediated protection against t-BHP-mediated decrease in proliferation.	tert-Butylhydroperoxide	144-149	sirtuin 1	Homo sapiens	25-30
23690869-2	2013	tert-butyl hydroperoxide caused a significant (P < 0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly (P < 0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver.	tert-Butylhydroperoxide	0-24	catalase	Rattus norvegicus	261-269
23690869-2	2013	tert-butyl hydroperoxide caused a significant (P < 0.05) elevation in conjugated dienes (CD) and malondialdehyde (MDA) levels, significantly (P < 0.05) decreased reduced glutathione (GSH) and GSH : GSSG ratio, and induced varying changes in activities of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase in the blood and liver.	tert-Butylhydroperoxide	0-24	glutathione-disulfide reductase	Rattus norvegicus	321-342
23266269-0	2013	Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes.	tert-Butylhydroperoxide	81-105	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
23266269-6	2013	This study indicates that ganodermanondiol exhibits potent cytoprotective effects on t-BHP-induced hepatotoxicity in human liver-derived HepG2 cells, presumably through Nrf2-mediated antioxidant enzymes and AMPK.	tert-Butylhydroperoxide	85-90	NFE2 like bZIP transcription factor 2	Homo sapiens	169-173
22610911-3	2013	Caco-2 cells pretreated with ferulate (5 or 15 muM) were exposed to t-BHP (100 muM), and ferulate suppressed the t-BHP-mediated increases in reactive species and epithelial permeability in Caco-2 cells.	tert-Butylhydroperoxide	68-73	latexin	Homo sapiens	79-82
22610911-3	2013	Caco-2 cells pretreated with ferulate (5 or 15 muM) were exposed to t-BHP (100 muM), and ferulate suppressed the t-BHP-mediated increases in reactive species and epithelial permeability in Caco-2 cells.	tert-Butylhydroperoxide	113-118	latexin	Homo sapiens	47-50
22610911-3	2013	Caco-2 cells pretreated with ferulate (5 or 15 muM) were exposed to t-BHP (100 muM), and ferulate suppressed the t-BHP-mediated increases in reactive species and epithelial permeability in Caco-2 cells.	tert-Butylhydroperoxide	113-118	latexin	Homo sapiens	79-82
22610911-5	2013	In addition, pretreatment with ferulate markedly protected cells against t-BHP-induced apoptosis, as evidenced by decreased nuclear condensation, cytochrome c release, and caspase-3 cleavage and an increased Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	73-78	cytochrome c, somatic	Homo sapiens	146-158
22610911-5	2013	In addition, pretreatment with ferulate markedly protected cells against t-BHP-induced apoptosis, as evidenced by decreased nuclear condensation, cytochrome c release, and caspase-3 cleavage and an increased Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	73-78	caspase 3	Homo sapiens	172-181
22610911-5	2013	In addition, pretreatment with ferulate markedly protected cells against t-BHP-induced apoptosis, as evidenced by decreased nuclear condensation, cytochrome c release, and caspase-3 cleavage and an increased Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	73-78	BCL2 associated X, apoptosis regulator	Homo sapiens	208-211
22610911-5	2013	In addition, pretreatment with ferulate markedly protected cells against t-BHP-induced apoptosis, as evidenced by decreased nuclear condensation, cytochrome c release, and caspase-3 cleavage and an increased Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	73-78	BCL2 apoptosis regulator	Homo sapiens	212-217
23016756-2	2012	The loss of 7-benzyloxy-4-(trifluoromethyl)coumarin (BFC) O-debenzylation activity of CYP3A4 was concentration-dependent with respect to PN, and the loss of BFC activity supported by NADPH-cytochrome P450 reductase (CPR) was much greater than that supported by tert-butyl hydroperoxide.	tert-Butylhydroperoxide	261-285	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
23016756-2	2012	The loss of 7-benzyloxy-4-(trifluoromethyl)coumarin (BFC) O-debenzylation activity of CYP3A4 was concentration-dependent with respect to PN, and the loss of BFC activity supported by NADPH-cytochrome P450 reductase (CPR) was much greater than that supported by tert-butyl hydroperoxide.	tert-Butylhydroperoxide	261-285	cytochrome p450 oxidoreductase	Homo sapiens	183-214
22980779-4	2012	The protective effect of WESP and their bioactive compounds in 0.2mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation.	tert-Butylhydroperoxide	69-74	BCL2 associated X, apoptosis regulator	Homo sapiens	283-286
22980779-4	2012	The protective effect of WESP and their bioactive compounds in 0.2mM t-BHP-induced HepG2 cells may be associated with positive regulation of GSH levels and antioxidant enzymes, decrease in ROS formation and TBARS generation, increase in the mitochondria membrane potential and Bcl-2/Bax ratio, as well as decrease in caspase-3 activation.	tert-Butylhydroperoxide	69-74	caspase 3	Homo sapiens	317-326
22956110-5	2012	Oxidative stress was induced by exposure of the cells to tert-butyl hydroperoxide (TBH) for 1 h. TBH (3,000 muM) induced an increase in biomarkers of oxidative stress, while maintaining cell viability and proliferation.	tert-Butylhydroperoxide	57-81	latexin	Homo sapiens	108-111
23169588-4	2012	IL-13, as well as IL-4, potentiated the cytotoxic effects of t-butyl hydroperoxide and hydrogen peroxide on mouse DA MN9D cells.	tert-Butylhydroperoxide	61-82	interleukin 13	Mus musculus	0-5
23169588-4	2012	IL-13, as well as IL-4, potentiated the cytotoxic effects of t-butyl hydroperoxide and hydrogen peroxide on mouse DA MN9D cells.	tert-Butylhydroperoxide	61-82	interleukin 4	Mus musculus	18-22
22956110-5	2012	Oxidative stress was induced by exposure of the cells to tert-butyl hydroperoxide (TBH) for 1 h. TBH (3,000 muM) induced an increase in biomarkers of oxidative stress, while maintaining cell viability and proliferation.	tert-Butylhydroperoxide	83-86	latexin	Homo sapiens	108-111
22956110-5	2012	Oxidative stress was induced by exposure of the cells to tert-butyl hydroperoxide (TBH) for 1 h. TBH (3,000 muM) induced an increase in biomarkers of oxidative stress, while maintaining cell viability and proliferation.	tert-Butylhydroperoxide	97-100	latexin	Homo sapiens	108-111
22956110-6	2012	In relation to the apical uptake of (3)H-FA, TBH (3,000 muM) reduced the cellular accumulation of (3)H-FA (10 nM), although the characteristics (kinetics, pH dependence, and inhibitory profile) of (3)H-FA uptake were not changed.	tert-Butylhydroperoxide	45-48	latexin	Homo sapiens	56-59
22836670-7	2012	Oxidative stress by exposure for 15-30 min to 1 mM H2O2 or 1 mM tert-butyl-hydroperoxide enhanced the cation conductance and increased cytosolic Ca2+ concentration, effects significantly less pronounced in erythrocytes from aqp-/- than in erythrocytes from aqp9+/+ mice.	tert-Butylhydroperoxide	64-88	aquaporin 9	Mus musculus	257-261
22563892-7	2012	Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on tBHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L-NMMA (NG-monomethyl-L-arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin fully inhibited it.	tert-Butylhydroperoxide	84-88	sirtuin 1	Homo sapiens	14-19
23036362-6	2012	We found that treating primary cultured mouse neurons with LKE provided significant protection against t-butyl hydroperoxide-induced neuronal death possibly through CRMP2 upregulation.	tert-Butylhydroperoxide	103-124	dihydropyrimidinase-like 2	Mus musculus	165-170
22698995-7	2012	Furthermore, Huh-7 cells transfected with let-7b, let-7c or miR-98 mimic showed increased resistance against oxidant injury induced by tert-butyl-hydroperoxide (tBuOOH), whereas the protection was abrogated by over-expression of Bach1.	tert-Butylhydroperoxide	135-159	microRNA let-7b	Homo sapiens	42-48
22698995-7	2012	Furthermore, Huh-7 cells transfected with let-7b, let-7c or miR-98 mimic showed increased resistance against oxidant injury induced by tert-butyl-hydroperoxide (tBuOOH), whereas the protection was abrogated by over-expression of Bach1.	tert-Butylhydroperoxide	135-159	microRNA let-7c	Homo sapiens	50-56
22698995-7	2012	Furthermore, Huh-7 cells transfected with let-7b, let-7c or miR-98 mimic showed increased resistance against oxidant injury induced by tert-butyl-hydroperoxide (tBuOOH), whereas the protection was abrogated by over-expression of Bach1.	tert-Butylhydroperoxide	135-159	microRNA 98	Homo sapiens	60-66
22698995-7	2012	Furthermore, Huh-7 cells transfected with let-7b, let-7c or miR-98 mimic showed increased resistance against oxidant injury induced by tert-butyl-hydroperoxide (tBuOOH), whereas the protection was abrogated by over-expression of Bach1.	tert-Butylhydroperoxide	135-159	BTB domain and CNC homolog 1	Homo sapiens	229-234
22739068-3	2012	Oxidative stress was induced with the pro-oxidant tert-butylhydroperoxide (50 and 250muM) in the HNSCC HN13 cell lineage either with (siSET) or without (siNC) SET knockdown.	tert-Butylhydroperoxide	50-73	MT-RNR2 like 13 (pseudogene)	Homo sapiens	103-107
22563892-7	2012	Inhibition of SIRT1 (sirtuin 1) by sirtinol partially reversed the effect of RWE on tBHP-induced senescence, whereas both the NOS (nitric oxide synthase) inhibitor L-NMMA (NG-monomethyl-L-arginine) and the COX (cyclo-oxygenase) inhibitor indomethacin fully inhibited it.	tert-Butylhydroperoxide	84-88	sirtuin 1	Homo sapiens	21-30
22508061-9	2012	The effect of rapamycin on TNF-alpha release was also mimicked by the antioxidant ROS scavenger Tempol (30 muM) and partially reversed by additional application of tert-butylhydroperoxide (10 muM).	tert-Butylhydroperoxide	164-187	tumor necrosis factor	Mus musculus	27-36
23256998-9	2012	RESULTS: Compared with those in the control group, the expression of miR-181a in 100 and 200 micromol/L t-BHP exposure groups was significantly decreased, with expression ratios of 0.744 and 0.766 (P < 0.01), while the expression of miR-181d in 50 micromol/L t-BHP exposure group was significantly increased, with an expression ratio of 1.29 (P < 0.01).	tert-Butylhydroperoxide	104-109	microRNA 181a-2	Mus musculus	69-77
23256998-9	2012	RESULTS: Compared with those in the control group, the expression of miR-181a in 100 and 200 micromol/L t-BHP exposure groups was significantly decreased, with expression ratios of 0.744 and 0.766 (P < 0.01), while the expression of miR-181d in 50 micromol/L t-BHP exposure group was significantly increased, with an expression ratio of 1.29 (P < 0.01).	tert-Butylhydroperoxide	104-109	microRNA 181d	Homo sapiens	236-244
23256998-9	2012	RESULTS: Compared with those in the control group, the expression of miR-181a in 100 and 200 micromol/L t-BHP exposure groups was significantly decreased, with expression ratios of 0.744 and 0.766 (P < 0.01), while the expression of miR-181d in 50 micromol/L t-BHP exposure group was significantly increased, with an expression ratio of 1.29 (P < 0.01).	tert-Butylhydroperoxide	262-267	microRNA 181a-2	Mus musculus	69-77
22836768-11	2012	Following tBHP treatment, Nrf2 translocated from cytoplasm to nuclei in normal CECs, whereas Nrf2 nuclear localization was not observed in FECD.	tert-Butylhydroperoxide	10-14	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
21937211-7	2012	Overexpression of Nrf2 increased GSH content and efficiently protected t-BHP-induced mitochondrial membrane potential loss.	tert-Butylhydroperoxide	71-76	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
22584685-6	2012	Assessment of fatty acids using electrospray ionization-mass spectrometry revealed that ER-iPLA(2)gamma mediates the TBHP-induced release of arachidonic acid (20:4), linoleic acid (18:2), and their oxidized forms (18:2-OH, 18:2-OOH, 20:4-OH, 20:4-OOH, 20:4-(OH)(3).	tert-Butylhydroperoxide	117-121	calcium-independent phospholipase A2-gamma	Oryctolagus cuniculus	91-103
22580151-5	2012	Our results show that both APE1 expression level and its redox activity are essential for maintenance of the mitochondrial function after tert-butylhydroperoxide-induced oxidative stress.	tert-Butylhydroperoxide	138-161	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	27-31
23717125-3	2012	Also, SG treatment dose-dependently relieved the increment of activities of hepatic enzymes, such as aspartate aminotrasferase and alanine aminotransferase, and lipid peroxidation mediated by t-BHP treatment in HepG2 cells.	tert-Butylhydroperoxide	192-197	glutamic--pyruvic transaminase	Homo sapiens	131-155
22474296-5	2012	We also found the positive cooperativity of the substrate t-butyl hydroperoxide binding to Ahp1 homodimer at a Hill coefficient of ~2, which enabled Ahp1 to eliminate hydroperoxide at much higher efficiency.	tert-Butylhydroperoxide	58-79	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	91-95
22474296-5	2012	We also found the positive cooperativity of the substrate t-butyl hydroperoxide binding to Ahp1 homodimer at a Hill coefficient of ~2, which enabled Ahp1 to eliminate hydroperoxide at much higher efficiency.	tert-Butylhydroperoxide	58-79	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	149-153
22138732-11	2012	Over-expression of Cx43 reduced tBH-induced secretion of VEGF from ARPE-19 cells.	tert-Butylhydroperoxide	32-35	gap junction protein alpha 1	Homo sapiens	19-23
22138732-11	2012	Over-expression of Cx43 reduced tBH-induced secretion of VEGF from ARPE-19 cells.	tert-Butylhydroperoxide	32-35	vascular endothelial growth factor A	Homo sapiens	57-61
22392610-2	2012	Enzymatic assays showed that Prx1 is a thioredoxin-linked peroxidase which reduces both hydrogen peroxide (H(2)O(2)) and tert-butyl hydroperoxide (t-BOOH).	tert-Butylhydroperoxide	121-145	thioredoxin peroxidase PRX1	Saccharomyces cerevisiae S288C	29-33
22179018-7	2012	Furthermore, TBHP and H(2)O(2) oxidized mitochondrial calpain 10, decreased mitochondrial, but not cytosolic calpain 10, and pretreatment with MG132 blocked TBHP-induced degradation of calpain 10.	tert-Butylhydroperoxide	13-17	calpain 10	Homo sapiens	54-64
22179018-7	2012	Furthermore, TBHP and H(2)O(2) oxidized mitochondrial calpain 10, decreased mitochondrial, but not cytosolic calpain 10, and pretreatment with MG132 blocked TBHP-induced degradation of calpain 10.	tert-Butylhydroperoxide	13-17	calpain 10	Homo sapiens	109-119
22179018-7	2012	Furthermore, TBHP and H(2)O(2) oxidized mitochondrial calpain 10, decreased mitochondrial, but not cytosolic calpain 10, and pretreatment with MG132 blocked TBHP-induced degradation of calpain 10.	tert-Butylhydroperoxide	13-17	calpain 10	Homo sapiens	109-119
22179018-7	2012	Furthermore, TBHP and H(2)O(2) oxidized mitochondrial calpain 10, decreased mitochondrial, but not cytosolic calpain 10, and pretreatment with MG132 blocked TBHP-induced degradation of calpain 10.	tert-Butylhydroperoxide	157-161	calpain 10	Homo sapiens	54-64
22778252-7	2012	Moreover, mitochondria from iPLA(2)gamma(-/-) mouse liver were resistant to Ca(2+)/t-butyl hydroperoxide-induced mPTP opening in comparison with wild-type littermates.	tert-Butylhydroperoxide	83-104	patatin-like phospholipase domain containing 8	Mus musculus	28-40
22778252-8	2012	In support of these findings, cytochrome c release from iPLA(2)gamma(-/-) mitochondria was dramatically decreased in response to calcium in the presence or absence of either t-butyl hydroperoxide or phenylarsine oxide in comparison with wild-type littermates.	tert-Butylhydroperoxide	174-195	patatin-like phospholipase domain containing 8	Mus musculus	56-68
22372402-6	2012	Complex 2 was applied in the catalytic epoxidation of the biorenewable olefins DL-limonene (Lim) and methyl oleate (Ole), using tert-butylhydroperoxide (TBHP) as an oxygen donor, under mild reaction conditions (55  C, air).	tert-Butylhydroperoxide	128-151	PDZ and LIM domain 5	Homo sapiens	92-95
22372402-6	2012	Complex 2 was applied in the catalytic epoxidation of the biorenewable olefins DL-limonene (Lim) and methyl oleate (Ole), using tert-butylhydroperoxide (TBHP) as an oxygen donor, under mild reaction conditions (55  C, air).	tert-Butylhydroperoxide	153-157	PDZ and LIM domain 5	Homo sapiens	92-95
22067043-2	2012	Our aim was to evaluate the relative role of each activity in Prdx6-mediated protection of mouse pulmonary microvascular endothelial cells (PMVECs) against the peroxidative stress of treatment with tert-butyl hydroperoxide (tBOOH).	tert-Butylhydroperoxide	198-222	peroxiredoxin 6	Mus musculus	62-67
22067043-2	2012	Our aim was to evaluate the relative role of each activity in Prdx6-mediated protection of mouse pulmonary microvascular endothelial cells (PMVECs) against the peroxidative stress of treatment with tert-butyl hydroperoxide (tBOOH).	tert-Butylhydroperoxide	224-229	peroxiredoxin 6	Mus musculus	62-67
22067043-3	2012	RESULTS: PMVEC from Prdx6 null mice showed increased lethality on tBOOH exposure (50-200 muM) compared with wild-type (WT) controls.	tert-Butylhydroperoxide	66-71	peroxiredoxin 6	Mus musculus	20-25
22174413-7	2012	Embryos in which Nrf2a expression had been knocked down with morpholino oligonucleotides were more sensitive to tert-butylhydroperoxide but not tert-butylhydroquinone, whereas knockdown of Nrf2b did not affect sensitivity of embryos to either chemical.	tert-Butylhydroperoxide	112-135	nfe2 like bZIP transcription factor 2a	Danio rerio	17-22
22041107-4	2012	In the present study, the effects of diamide [1,1"-azobis(N,N-dimethylformamide)] and tert-butyl hydroperoxide (TBHP) on the activity of rSULT1A1 in rat hepatic slices were compared with the effects of these oxidants on a homogeneous preparation of the enzyme.	tert-Butylhydroperoxide	86-110	sulfotransferase family 1A member 1	Rattus norvegicus	137-145
22041107-4	2012	In the present study, the effects of diamide [1,1"-azobis(N,N-dimethylformamide)] and tert-butyl hydroperoxide (TBHP) on the activity of rSULT1A1 in rat hepatic slices were compared with the effects of these oxidants on a homogeneous preparation of the enzyme.	tert-Butylhydroperoxide	112-116	sulfotransferase family 1A member 1	Rattus norvegicus	137-145
22041107-8	2012	Exposure of homogeneous rSULT1A1 to diamide or TBHP also increased the rate of sulfation of 7-HC, although the optimal concentrations of diamide and TBHP were lower (50- and 100-fold, respectively) than those required for effects with the hepatic slices.	tert-Butylhydroperoxide	47-51	sulfotransferase family 1A member 1	Rattus norvegicus	24-32
22041107-8	2012	Exposure of homogeneous rSULT1A1 to diamide or TBHP also increased the rate of sulfation of 7-HC, although the optimal concentrations of diamide and TBHP were lower (50- and 100-fold, respectively) than those required for effects with the hepatic slices.	tert-Butylhydroperoxide	149-153	sulfotransferase family 1A member 1	Rattus norvegicus	24-32
22041107-9	2012	These results indicate that both diamide and TBHP may modify the rSULT1A1 in intact cells in a manner similar to that observed with the homogeneous purified enzyme.	tert-Butylhydroperoxide	45-49	sulfotransferase family 1A member 1	Rattus norvegicus	65-73
22854627-6	2012	As a result, energy depletion (48 h glucose removal) and oxidative stress (30 min exposure to 0.3 mM tert-butylhydroperoxide) increased Fluo-3 fluorescence, decreased the erythrocyte forward scatter and enhanced the percentage of annexin-V-binding erythrocytes.	tert-Butylhydroperoxide	101-124	annexin A5	Homo sapiens	230-239
22876140-0	2012	Inhibition of p38 mitogen-activated protein kinase phosphorylation decrease tert-butyl hydroperoxide-induced apoptosis in human trabecular meshwork cells.	tert-Butylhydroperoxide	76-100	mitogen-activated protein kinase 14	Homo sapiens	14-17
22518128-0	2012	Exendin-4 Protects MIN6 Cells from t-BHP-Induced Apoptosis via IRE1-JNK-Caspase-3 Signaling.	tert-Butylhydroperoxide	35-40	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	63-67
22518128-10	2012	Exendin-4 was found to inhibit t-BHP-induced apoptosis in pancreatic beta-cells by downregulating caspase-3 activity.	tert-Butylhydroperoxide	31-36	caspase 3	Mus musculus	98-107
22876140-3	2012	This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert-butyl hydroperoxide (tBHP)-induced apoptosis of human trabecular meshwork (iHTM) cells.	tert-Butylhydroperoxide	91-115	mitogen-activated protein kinase 14	Homo sapiens	41-44
22876140-3	2012	This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert-butyl hydroperoxide (tBHP)-induced apoptosis of human trabecular meshwork (iHTM) cells.	tert-Butylhydroperoxide	117-121	mitogen-activated protein kinase 14	Homo sapiens	41-44
21842414-8	2011	Also, ROS generator phenazine methosulfate and tert-Butyl hydroperoxide may induce phosphorylation of paxillin and activation of PKC.	tert-Butylhydroperoxide	47-71	protein kinase C alpha	Homo sapiens	129-132
23213352-2	2012	We find that incubating INS-1 cells with IL-1beta and IFN-gamma, with STZ, or with TBHP causes increased expression of iPLA(2)gamma mRNA and protein.	tert-Butylhydroperoxide	83-87	insulin 1	Rattus norvegicus	24-29
22916248-13	2012	Silencing PRDX2 in moDCs by means of siRNA significantly increased CM-DCF fluorescence and cell death upon tert-BHP-stimulation.	tert-Butylhydroperoxide	107-115	peroxiredoxin 2	Homo sapiens	10-15
22053949-1	2011	beta-1,3-Dicarbonyl aldehydes were synthesized by iron-catalyzed oxidative reactions between 1,3-dicarbonyl compounds and two molecules of tertiary amines in the presence of tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	174-198	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	0-8
22053949-1	2011	beta-1,3-Dicarbonyl aldehydes were synthesized by iron-catalyzed oxidative reactions between 1,3-dicarbonyl compounds and two molecules of tertiary amines in the presence of tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	200-204	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	0-8
21964506-4	2011	Treatment with butein and phloretin markedly attenuated tBHP-induced peroxide formation, and this amelioration was reversed by l-buthionine-S-sulfoximine [a glutamate cysteine ligase (GCL) inhibitor] and zinc protoporphyrin [a heme oxygenase 1 (HO-1) inhibitor].	tert-Butylhydroperoxide	56-60	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	184-187
21964506-4	2011	Treatment with butein and phloretin markedly attenuated tBHP-induced peroxide formation, and this amelioration was reversed by l-buthionine-S-sulfoximine [a glutamate cysteine ligase (GCL) inhibitor] and zinc protoporphyrin [a heme oxygenase 1 (HO-1) inhibitor].	tert-Butylhydroperoxide	56-60	heme oxygenase 1	Rattus norvegicus	227-243
21964506-4	2011	Treatment with butein and phloretin markedly attenuated tBHP-induced peroxide formation, and this amelioration was reversed by l-buthionine-S-sulfoximine [a glutamate cysteine ligase (GCL) inhibitor] and zinc protoporphyrin [a heme oxygenase 1 (HO-1) inhibitor].	tert-Butylhydroperoxide	56-60	heme oxygenase 1	Rattus norvegicus	245-249
21892616-3	2011	When these samples were used at a dose of 10-40 mug/mL-1, they significantly protected the t-BHP-induced cell death in HepG2 cells.	tert-Butylhydroperoxide	91-96	L1 cell adhesion molecule	Mus musculus	52-56
21892616-4	2011	Among fractions, ethyl acetate fraction (EF) and n-butanol extract (BF) exhibited potent hepatoprotective activities (62.60% for EF and 64.86% for BF) in t-BHP-injured HepG2 cells at a concentration of 10 mug/mL-1.	tert-Butylhydroperoxide	154-159	L1 cell adhesion molecule	Mus musculus	209-213
20510595-0	2011	Protective effect of the peroxisome proliferator-activated receptor (PPAR)-gamma, ligand rosiglitazone on tert-butyl hydroperoxide-induced QZG cell injury.	tert-Butylhydroperoxide	106-130	peroxisome proliferator activated receptor gamma	Homo sapiens	25-80
21839169-6	2011	We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	105-132	radixin	Rattus norvegicus	54-61
21839169-6	2011	We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	105-132	ATP binding cassette subfamily C member 2	Rattus norvegicus	94-98
21839169-6	2011	We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	134-139	radixin	Rattus norvegicus	54-61
21839169-6	2011	We detected a significant decrease in the amount of p-radixin that co-immunoprecipitated with Mrp2 after tertiary-butylhydroperoxide (t-BHP) treatment.	tert-Butylhydroperoxide	134-139	ATP binding cassette subfamily C member 2	Rattus norvegicus	94-98
21839169-8	2011	A PKC and protein phosphatase (PP)-1/2A inhibitor, but not a PP-2A selective inhibitor, prevented the t-BHP-induced decrease of p-radixin and subsequent canalicular Mrp2 localization.	tert-Butylhydroperoxide	102-107	radixin	Rattus norvegicus	130-137
21839169-8	2011	A PKC and protein phosphatase (PP)-1/2A inhibitor, but not a PP-2A selective inhibitor, prevented the t-BHP-induced decrease of p-radixin and subsequent canalicular Mrp2 localization.	tert-Butylhydroperoxide	102-107	ATP binding cassette subfamily C member 2	Rattus norvegicus	165-169
22033140-2	2011	CEE significantly blocked the oxidative stress and cytotoxicity induced by tert-butyl hydroperoxide (t-BHP) in HepG2 cells.	tert-Butylhydroperoxide	75-99	guided entry of tail-anchored proteins factor 4	Homo sapiens	0-3
22033140-2	2011	CEE significantly blocked the oxidative stress and cytotoxicity induced by tert-butyl hydroperoxide (t-BHP) in HepG2 cells.	tert-Butylhydroperoxide	101-106	guided entry of tail-anchored proteins factor 4	Homo sapiens	0-3
21895413-3	2011	has strong hepatoprotective effects against oxidative stress induced by tert-butylhydroperoxide (t-BHP).	tert-Butylhydroperoxide	97-102	telomerase reverse transcriptase	Homo sapiens	72-76
22034285-2	2011	The time-dependent changes in cellular GSH induced by tBHP were monitored as a measure of GSH recovery capacity (GRC), of which glutathione reductase (GR)-mediated glutathione redox cycling and gamma-glutamate cysteine ligase (GCL)-mediated GSH synthesis were found to play an essential role.	tert-Butylhydroperoxide	54-58	glutathione-disulfide reductase	Rattus norvegicus	128-149
22034285-2	2011	The time-dependent changes in cellular GSH induced by tBHP were monitored as a measure of GSH recovery capacity (GRC), of which glutathione reductase (GR)-mediated glutathione redox cycling and gamma-glutamate cysteine ligase (GCL)-mediated GSH synthesis were found to play an essential role.	tert-Butylhydroperoxide	54-58	glutathione-disulfide reductase	Rattus norvegicus	113-115
21871559-5	2011	Low tert-butylhydroperoxide (tBH) concentrations similarly mediated promoter activation, but the maximal activation dose was decreased 10-fold by insulin.	tert-Butylhydroperoxide	4-27	insulin	Homo sapiens	146-153
21871559-5	2011	Low tert-butylhydroperoxide (tBH) concentrations similarly mediated promoter activation, but the maximal activation dose was decreased 10-fold by insulin.	tert-Butylhydroperoxide	29-32	insulin	Homo sapiens	146-153
21871559-6	2011	Insulin-tBH coadministration abrogated the low or high glucose requirement for promoter activation, suggesting possible ROS involvement.	tert-Butylhydroperoxide	8-11	insulin	Homo sapiens	0-7
20510595-6	2011	Under 400 muM t-BHP treatment, QZG cell displayed significant loss of viability and dramatic morphological changes characterized by changing in shape from triangle to spherical, disappearance of cell cilia, swollen mitochondrial and typical apoptotic alteration such as condensation of chromatin, and appearance of crescent under light microscopy and electronic microscopy, respectively.	tert-Butylhydroperoxide	14-19	latexin	Homo sapiens	10-13
20510595-9	2011	25 muM rosiglitazone treatment inhibited the t-BHP-induced cell toxicity significantly by restoring the cell viability, reducing cell population undergone apoptosis to normal level (3.5%) and ameliorating t-BHP-induced pathological changes.	tert-Butylhydroperoxide	45-50	latexin	Homo sapiens	3-6
20510595-9	2011	25 muM rosiglitazone treatment inhibited the t-BHP-induced cell toxicity significantly by restoring the cell viability, reducing cell population undergone apoptosis to normal level (3.5%) and ameliorating t-BHP-induced pathological changes.	tert-Butylhydroperoxide	205-210	latexin	Homo sapiens	3-6
20510595-10	2011	Real-time RT-PCR results showed that 400 muM t-BHP caused dramatic down-regulation of PPARgamma expression in QZG cells, whereas combining treatment with 25 muM rosiglitazone resistant to PPARgamma expression to normal level partially.	tert-Butylhydroperoxide	45-50	latexin	Homo sapiens	41-44
20510595-10	2011	Real-time RT-PCR results showed that 400 muM t-BHP caused dramatic down-regulation of PPARgamma expression in QZG cells, whereas combining treatment with 25 muM rosiglitazone resistant to PPARgamma expression to normal level partially.	tert-Butylhydroperoxide	45-50	peroxisome proliferator activated receptor gamma	Homo sapiens	86-95
20726785-5	2010	Moreover, TRF pretreatment prevented a significant increase in glutathione peroxidase, catalase, and superoxide dismutase activities induced by TBHP.	tert-Butylhydroperoxide	144-148	catalase	Homo sapiens	87-95
21596788-3	2011	We show that DSBs generated following acute exposure of G0/G1 cells to the oxidative damaging agent, tert-butyl hydroperoxide (TBH), are repaired with fast and slow components of similar magnitude to IR-induced DSBs and have a similar requirement for ATM and Artemis.	tert-Butylhydroperoxide	101-125	ATM serine/threonine kinase	Homo sapiens	251-254
21596788-3	2011	We show that DSBs generated following acute exposure of G0/G1 cells to the oxidative damaging agent, tert-butyl hydroperoxide (TBH), are repaired with fast and slow components of similar magnitude to IR-induced DSBs and have a similar requirement for ATM and Artemis.	tert-Butylhydroperoxide	127-130	ATM serine/threonine kinase	Homo sapiens	251-254
21693609-12	2011	Forced overexpression of miR-23a decreased H(2)O(2) or tBH-induced Fas upregulation, and this effect was blocked by downregulation of miR-23a.	tert-Butylhydroperoxide	55-58	microRNA 23a	Homo sapiens	25-32
21693609-12	2011	Forced overexpression of miR-23a decreased H(2)O(2) or tBH-induced Fas upregulation, and this effect was blocked by downregulation of miR-23a.	tert-Butylhydroperoxide	55-58	microRNA 23a	Homo sapiens	134-141
21348939-9	2011	A bioassay experiment was conducted to analyze its potential function and showed that E. coli cells expressing GhAnx1 were protected from tert-butyl hydroperoxide (tBH) stress, suggesting that it had a potential antioxidative role.	tert-Butylhydroperoxide	138-162	annexin D2-like	Gossypium hirsutum	111-117
21348939-9	2011	A bioassay experiment was conducted to analyze its potential function and showed that E. coli cells expressing GhAnx1 were protected from tert-butyl hydroperoxide (tBH) stress, suggesting that it had a potential antioxidative role.	tert-Butylhydroperoxide	164-167	annexin D2-like	Gossypium hirsutum	111-117
21239532-4	2011	We noted that tBH caused a concentration-dependent necrosis in RPMEC, and pretreatment of RPMEC with SNO-Alb dose-dependently decreased the sensitivity of these cells to tBH.	tert-Butylhydroperoxide	170-173	albumin	Rattus norvegicus	105-108
21239532-9	2011	Therefore, SNO-Alb is cytoprotective against models of oxidant-induced necrosis (tBH) and inhibitors of cellular respiration and apoptosis (H(2)S) in both pulmonary endothelium and smooth muscle, respectively, and a component of such protection can be attributed to a SH-Alb-mediated activation of constitutive NOS.	tert-Butylhydroperoxide	81-84	albumin	Rattus norvegicus	15-18
20922651-11	2011	T-BHP induced the phosphorylation of ERK 1/2, JNK and p38 MAPK, which were all impeded by pretreatments with MAM, indicating that MAM may act as a potent antioxidant which significantly interferes with the MAPK apoptotic cascades, probably rescuing cells by inhibiting the death pathways.	tert-Butylhydroperoxide	0-5	mitogen activated protein kinase 3	Rattus norvegicus	37-44
20922651-11	2011	T-BHP induced the phosphorylation of ERK 1/2, JNK and p38 MAPK, which were all impeded by pretreatments with MAM, indicating that MAM may act as a potent antioxidant which significantly interferes with the MAPK apoptotic cascades, probably rescuing cells by inhibiting the death pathways.	tert-Butylhydroperoxide	0-5	mitogen-activated protein kinase 8	Rattus norvegicus	46-49
20922651-11	2011	T-BHP induced the phosphorylation of ERK 1/2, JNK and p38 MAPK, which were all impeded by pretreatments with MAM, indicating that MAM may act as a potent antioxidant which significantly interferes with the MAPK apoptotic cascades, probably rescuing cells by inhibiting the death pathways.	tert-Butylhydroperoxide	0-5	mitogen activated protein kinase 3	Rattus norvegicus	58-62
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	14-17
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	cyclin dependent kinase inhibitor 2A	Homo sapiens	59-62
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	cyclin dependent kinase inhibitor 2A	Homo sapiens	63-68
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	120-123
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	ataxin 1	Homo sapiens	127-132
21657082-12	2011	The effect of Rg1 delaying aging is better than treatment, p16(INK4a) may be play a key role in the antiaging effect of Rg1 to Sca-1 + HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	161-166	fucosyltransferase 1 (H blood group)	Homo sapiens	135-138
20847119-5	2011	PPARgamma ligands were found to have differential modulatory effects on tBH-induced apoptosis of RPE cells.	tert-Butylhydroperoxide	72-75	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
20847119-7	2011	Downregulation of PPARgamma expression by an siRNA resulted in enhanced cell death in response to tBH treatment and blocked the cytoprotective effect of troglitazone consistent with a role of PPARgamma in mediating this response.	tert-Butylhydroperoxide	98-101	peroxisome proliferator activated receptor gamma	Homo sapiens	18-27
21132465-4	2011	Sca-1(+)HSC induced aging by tert-butylhydroperoxide (t-BHP, final concentration of 100 mumol/L) for 6 h to establish the murine HSC aging model in vitro.	tert-Butylhydroperoxide	29-52	ataxin 1	Mus musculus	0-5
21132465-4	2011	Sca-1(+)HSC induced aging by tert-butylhydroperoxide (t-BHP, final concentration of 100 mumol/L) for 6 h to establish the murine HSC aging model in vitro.	tert-Butylhydroperoxide	54-59	ataxin 1	Mus musculus	0-5
21132465-9	2011	After 6 h cocultured with 100 mumol/L t-BHP, the ability of aging Sca-1(+) HSC to form mixed hematopoietic progenitor colony, self-renewal and multi-differentiation were decreased significantly.	tert-Butylhydroperoxide	38-43	ataxin 1	Mus musculus	66-71
21132465-13	2011	The t-BHP can induce Sca-1(+) HSC senescence in vitro.	tert-Butylhydroperoxide	4-9	ataxin 1	Mus musculus	21-26
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	cyclin dependent kinase inhibitor 2A	Mus musculus	36-39
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	cyclin dependent kinase inhibitor 2A	Mus musculus	40-45
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	cyclin dependent kinase inhibitor 2D	Mus musculus	66-74
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	transformation related protein 53, pseudogene	Mus musculus	80-83
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	84-87
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	88-92
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	93-97
21132465-14	2011	The signal transduction pathways of p16(INK4a)-retinoblastoma and P19(Arf)-Mdm2-P53-P21(Cip1/Waf1) may play key roles in the Sca-1(+) HSC senescence induced by t-BHP.	tert-Butylhydroperoxide	160-165	ataxin 1	Mus musculus	125-130
21248136-10	2011	Combined application of inhibitors of ERK (U0126) and PKA (KT5720) was necessary to block completely the excitatory effects of a ROS donor (tBOOH).	tert-Butylhydroperoxide	140-145	EPH receptor B2	Homo sapiens	38-41
21223818-10	2010	CONCLUSIONS: Rg1 can effectively delay the t-BHP-induced senescence of HSCs.	tert-Butylhydroperoxide	43-48	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	13-16
21659470-5	2011	However, compared with CYP2B6.1, CYP2B6.8 retains 77% of its 7-EFC O-deethylase activity in the presence of tert-butyl hydroperoxide as an alternative oxidant, indicating that the heme and the active site are catalytically competent.	tert-Butylhydroperoxide	108-132	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	33-39
21707031-8	2011	Oxidative stress (30 min 0.3 mM tert-butylhydroperoxide) again significantly increased Fluo-3 fluorescence and triggered annexin binding, effects again in part significantly blunted by phlorhizin (Fluo-3 fluorescence >= 50 muM, annexin-binding >= 10 muM).	tert-Butylhydroperoxide	32-55	latexin	Homo sapiens	226-229
21707031-8	2011	Oxidative stress (30 min 0.3 mM tert-butylhydroperoxide) again significantly increased Fluo-3 fluorescence and triggered annexin binding, effects again in part significantly blunted by phlorhizin (Fluo-3 fluorescence >= 50 muM, annexin-binding >= 10 muM).	tert-Butylhydroperoxide	32-55	latexin	Homo sapiens	256-259
21659008-6	2011	Interestingly, cyt-c entrapped in agarose hydrogel on EPPGE and GC could catalyze the electroreduction of trichloroacetic acid (TCA) and tert-butyl hydroperoxide (t-BuOOH) in [Bmim][BF(4)], but could not in [Bmim][Br].	tert-Butylhydroperoxide	137-161	cytochrome c, somatic	Homo sapiens	15-20
21046126-9	2011	Hence, Caco2 cells treated 20 h with the flavanols, especially PB2, and then submitted to an oxidative stress induced by a pro-oxidant, tert-butyl-hydroperoxide, showed a reduced ROS production, restricted activation of caspase 3 and higher viability than cells plainly submitted to the stressor.	tert-Butylhydroperoxide	136-160	caspase 3	Homo sapiens	220-229
21683104-7	2011	Moreover, TBHP treatment was associated with the loss of mitochondrial membrane potential, and it induced cell apoptosis through the mitochondrial-mediated pathway involving the down-regulation of Bcl-2 expression and up-regulation of the Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	10-14	B cell leukemia/lymphoma 2	Mus musculus	197-202
21683104-7	2011	Moreover, TBHP treatment was associated with the loss of mitochondrial membrane potential, and it induced cell apoptosis through the mitochondrial-mediated pathway involving the down-regulation of Bcl-2 expression and up-regulation of the Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	10-14	BCL2-associated X protein	Mus musculus	239-242
21683104-7	2011	Moreover, TBHP treatment was associated with the loss of mitochondrial membrane potential, and it induced cell apoptosis through the mitochondrial-mediated pathway involving the down-regulation of Bcl-2 expression and up-regulation of the Bax/Bcl-2 ratio.	tert-Butylhydroperoxide	10-14	B cell leukemia/lymphoma 2	Mus musculus	243-248
21549097-7	2011	We also found that tert-butylhydroperoxide (t-BHP)-induced oxidative damage in both WT and P2K mouse embryonic fibroblast (MEF) cells resulted in the up-regulation of SOD1 levels.	tert-Butylhydroperoxide	19-42	superoxide dismutase 1, soluble	Mus musculus	167-171
21549097-7	2011	We also found that tert-butylhydroperoxide (t-BHP)-induced oxidative damage in both WT and P2K mouse embryonic fibroblast (MEF) cells resulted in the up-regulation of SOD1 levels.	tert-Butylhydroperoxide	44-49	superoxide dismutase 1, soluble	Mus musculus	167-171
21391895-0	2011	Protective role of a coumarin-derived schiff base scaffold against tertiary butyl hydroperoxide (TBHP)-induced oxidative impairment and cell death via MAPKs, NF-kappaB and mitochondria-dependent pathways.	tert-Butylhydroperoxide	97-101	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	158-167
21391895-1	2011	The present study investigated the antioxidant signalling mechanism of a coumarin-derived schiff base (CSB) scaffold against tert-butylhydroperoxide (TBHP) induced oxidative insult in murine hepatocytes.	tert-Butylhydroperoxide	125-148	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	103-106
21391895-1	2011	The present study investigated the antioxidant signalling mechanism of a coumarin-derived schiff base (CSB) scaffold against tert-butylhydroperoxide (TBHP) induced oxidative insult in murine hepatocytes.	tert-Butylhydroperoxide	150-154	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	103-106
21391895-4	2011	TBHP also activated phospho-ERK1/2, phospho-p38 and NF-kappaB, altered the Bcl-2/Bad ratio, reduced mitochondrial membrane potential, released cytochrome C and activated caspase 3, suggesting that TBHP induced oxidative stress responsive cell death via apoptotic pathway.	tert-Butylhydroperoxide	0-4	mitogen-activated protein kinase 14	Mus musculus	44-47
21391895-4	2011	TBHP also activated phospho-ERK1/2, phospho-p38 and NF-kappaB, altered the Bcl-2/Bad ratio, reduced mitochondrial membrane potential, released cytochrome C and activated caspase 3, suggesting that TBHP induced oxidative stress responsive cell death via apoptotic pathway.	tert-Butylhydroperoxide	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
21391895-4	2011	TBHP also activated phospho-ERK1/2, phospho-p38 and NF-kappaB, altered the Bcl-2/Bad ratio, reduced mitochondrial membrane potential, released cytochrome C and activated caspase 3, suggesting that TBHP induced oxidative stress responsive cell death via apoptotic pathway.	tert-Butylhydroperoxide	0-4	B cell leukemia/lymphoma 2	Mus musculus	75-80
21391895-4	2011	TBHP also activated phospho-ERK1/2, phospho-p38 and NF-kappaB, altered the Bcl-2/Bad ratio, reduced mitochondrial membrane potential, released cytochrome C and activated caspase 3, suggesting that TBHP induced oxidative stress responsive cell death via apoptotic pathway.	tert-Butylhydroperoxide	0-4	caspase 3	Mus musculus	170-179
21347497-7	2011	Various DEPMPO-OOR (R = Me, primary or secondary alkyl group) spin adducts were unambiguously characterized and the formation of DEPMPO-OOCH(3) was clearly established during the reaction of tert-butylhydroperoxide with chloroperoxidase and cytochrome c.	tert-Butylhydroperoxide	191-214	cytochrome c, somatic	Homo sapiens	241-253
20584199-3	2011	In this study, we demonstrate that the inhibition of the diclofenac-induced COX-2 activity in J774.2 cells by paracetamol is not related to the intracellular LHP tone as paracetamol inhibited this activity in the absence and presence of T-butyl hydroperoxide, which is an LHP donor, to the same extents.	tert-Butylhydroperoxide	237-258	cytochrome c oxidase II, mitochondrial	Mus musculus	76-81
21212070-0	2011	Different consequences of reactions with hydrogen peroxide and t-butyl hydroperoxide in the hyperoxidative inactivation of rat peroxiredoxin-4.	tert-Butylhydroperoxide	63-84	peroxiredoxin 4	Rattus norvegicus	127-142
21786535-4	2011	Cell exposure to t-BHP also increased a non-inactivating I(Na) (I(Na(NI)) elicited by long-lasting ramp pulses.	tert-Butylhydroperoxide	17-22	internexin neuronal intermediate filament protein, alpha	Mus musculus	64-72
21786535-5	2011	The t-BHP-induced increase of I(Na(NI)) was reversed by a further application of riluzole (10 microM) or oxcarbazepine (10 microM).	tert-Butylhydroperoxide	4-9	internexin neuronal intermediate filament protein, alpha	Mus musculus	30-38
21136025-0	2011	Bisdemethoxycurcumin protects endothelial cells against t-BHP-induced cell damage by regulating the phosphorylation level of ERK1/2 and Akt.	tert-Butylhydroperoxide	56-61	AKT serine/threonine kinase 1	Homo sapiens	136-139
21136025-8	2011	The pre-treatment with Cur3 decreased t-BHP-induced ERK1/2 phosphorylation and increased t-BHP-induced Akt phosporylation but did not affect the phosphorylation of p38 or JNK.	tert-Butylhydroperoxide	89-94	AKT serine/threonine kinase 1	Homo sapiens	103-106
21136025-10	2011	These results suggest that the ERK1/2 and PI3K/Akt signaling pathways could be involved in the protective effects of Cur3 against t-BHP-induced damage in HUVECs.	tert-Butylhydroperoxide	130-135	AKT serine/threonine kinase 1	Homo sapiens	47-50
21797775-0	2011	Antioxidative effects of cherry leaves extract on tert-butyl hydroperoxide-mediated cytotoxicity through regulation of thioredoxin-2 protein expression levels.	tert-Butylhydroperoxide	50-74	thioredoxin 2	Homo sapiens	119-132
21036150-5	2010	Chloro-4-nitrobenzo-2-oxa-1,3-diazole was used to identify Cys-SOH modification of Cys36 in response to H(2)O(2), tert-butyl-hydroperoxide (tert-BHP), and cumene hydroperoxide (CHP) in Orp1(WT).	tert-Butylhydroperoxide	114-138	RP1 axonemal microtubule associated	Homo sapiens	185-189
21036150-5	2010	Chloro-4-nitrobenzo-2-oxa-1,3-diazole was used to identify Cys-SOH modification of Cys36 in response to H(2)O(2), tert-butyl-hydroperoxide (tert-BHP), and cumene hydroperoxide (CHP) in Orp1(WT).	tert-Butylhydroperoxide	140-148	RP1 axonemal microtubule associated	Homo sapiens	185-189
21036150-9	2010	The Phe38 mutation decreases Orp1 peroxidase activities in response to either tert-BHP or CHP.	tert-Butylhydroperoxide	78-86	RP1 axonemal microtubule associated	Homo sapiens	29-33
20727966-3	2010	Utilizing MCF7 cells overexpressing MGST1 we show significant protection against agents that are known to induce lipid peroxidation (e.g., cumene hydroperoxide and tert-butylhydroperoxide) and an end-product of lipid peroxidation (e.g., 4-hydroxy-2-nonenal).	tert-Butylhydroperoxide	164-187	microsomal glutathione S-transferase 1	Homo sapiens	36-41
20923208-9	2010	A rate constant determination for the reaction TBHP   products (rxn 3) was also obtained in the range 745-1014 K using OH data from behind both incident and reflected shock waves.	tert-Butylhydroperoxide	47-51	relaxin 3	Homo sapiens	64-69
20419557-8	2010	VOG protected TBHP-treated ECV-304 cells from death, significantly decreased MDA production, and increased superoxide dismutase (SOD) activity and mitochondrial membrane potential (DeltaPsi).	tert-Butylhydroperoxide	14-18	superoxide dismutase 1	Homo sapiens	107-127
20419557-8	2010	VOG protected TBHP-treated ECV-304 cells from death, significantly decreased MDA production, and increased superoxide dismutase (SOD) activity and mitochondrial membrane potential (DeltaPsi).	tert-Butylhydroperoxide	14-18	superoxide dismutase 1	Homo sapiens	129-132
19716280-7	2010	Only tBH-treated glyB cells displayed an elevated ratio of mt Bax/Bcl-2, activation of procaspases 9 and 3, and apoptosis promotion.	tert-Butylhydroperoxide	5-8	apoptosis regulator BAX	Cricetulus griseus	62-65
19716280-7	2010	Only tBH-treated glyB cells displayed an elevated ratio of mt Bax/Bcl-2, activation of procaspases 9 and 3, and apoptosis promotion.	tert-Butylhydroperoxide	5-8	apoptosis regulator Bcl-2	Cricetulus griseus	66-71
19716280-10	2010	Defective mt folate transporter sensitized glyB cells to elevated oxidative stress and tBH-induced apoptosis, partly mediated by depleted compartmental folate and mt dysfunction.	tert-Butylhydroperoxide	87-90	mitochondrial folate transporter/carrier	Cricetulus griseus	13-31
20496120-5	2010	The overexpression of Cpr1 drastically increased cell viability of yeast in the presence of stress inducers, such as cadmium, cobalt, copper, hydrogen peroxide, tert-butyl hydroperoxide (t-BOOH), and sodium dodecyl sulfate (SDS).	tert-Butylhydroperoxide	161-185	peptidylprolyl isomerase CPR1	Saccharomyces cerevisiae S288C	22-26
20058262-8	2010	Catalase, hypoxia-inducible factor-1alpha (HIF-1alpha), and glyceraldehyde 6-phosphate dehydrogenase (GAPDH) were significantly increased relative to untreated controls in explants treated four times with 100 microM tBHP, a regime that also resulted in a significant decrease in matrix metalloproteinase-3 (MMP-3) expression.	tert-Butylhydroperoxide	216-220	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-41
20058262-8	2010	Catalase, hypoxia-inducible factor-1alpha (HIF-1alpha), and glyceraldehyde 6-phosphate dehydrogenase (GAPDH) were significantly increased relative to untreated controls in explants treated four times with 100 microM tBHP, a regime that also resulted in a significant decrease in matrix metalloproteinase-3 (MMP-3) expression.	tert-Butylhydroperoxide	216-220	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	60-100
20058262-8	2010	Catalase, hypoxia-inducible factor-1alpha (HIF-1alpha), and glyceraldehyde 6-phosphate dehydrogenase (GAPDH) were significantly increased relative to untreated controls in explants treated four times with 100 microM tBHP, a regime that also resulted in a significant decrease in matrix metalloproteinase-3 (MMP-3) expression.	tert-Butylhydroperoxide	216-220	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	102-107
20406040-4	2010	We have found that function of a specific i-isoform of mitochondrial phospholipase A2 (mt-iPLA2) is activated by tert-butylhydroperoxide in isolated rat heart mitochondria.	tert-Butylhydroperoxide	113-136	phospholipase A2 group VI	Rattus norvegicus	90-95
20415419-8	2010	Western blot analysis revealed that 5HTP also markedly increased Bcl-2 expression and suppressed both p38MAPK and NF-kappaB activation in the t-BHP-treated human fibroblast cells.	tert-Butylhydroperoxide	142-147	mitogen-activated protein kinase 14	Homo sapiens	102-109
20100471-7	2010	OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved.	tert-Butylhydroperoxide	47-51	mitogen-activated protein kinase 8	Homo sapiens	260-263
20100471-7	2010	OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved.	tert-Butylhydroperoxide	47-51	mitogen-activated protein kinase 1	Homo sapiens	268-271
20100471-7	2010	OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved.	tert-Butylhydroperoxide	47-51	mitogen-activated protein kinase 14	Homo sapiens	281-284
20100471-9	2010	OA probably functions mainly through indirect biological effect and protects QZG cells against cytotoxicity induced by tBHP through increasing the generation of antioxidant and the expression of oxidative stress sensitive transcription factor-Nrf2, and MAP kinases, mainly JNK and ERK.	tert-Butylhydroperoxide	119-123	NFE2 like bZIP transcription factor 2	Homo sapiens	243-247
20100471-9	2010	OA probably functions mainly through indirect biological effect and protects QZG cells against cytotoxicity induced by tBHP through increasing the generation of antioxidant and the expression of oxidative stress sensitive transcription factor-Nrf2, and MAP kinases, mainly JNK and ERK.	tert-Butylhydroperoxide	119-123	mitogen-activated protein kinase 8	Homo sapiens	273-276
20100471-9	2010	OA probably functions mainly through indirect biological effect and protects QZG cells against cytotoxicity induced by tBHP through increasing the generation of antioxidant and the expression of oxidative stress sensitive transcription factor-Nrf2, and MAP kinases, mainly JNK and ERK.	tert-Butylhydroperoxide	119-123	mitogen-activated protein kinase 1	Homo sapiens	281-284
20119745-5	2010	In addition, the two mentioned compounds inhibit intracellular signalling mechanisms leading to apoptotic cell death, namely those mediated by mitochondria, which was confirmed by their ability to overcome t-BHP-induced morphological changes in the mitochondrial network, loss of mitochondrial membrane potential, increased expression of the pro-apoptotic proteins p53, Bax and AIF and activation of caspases-3 and -9.	tert-Butylhydroperoxide	206-211	tumor protein p53	Homo sapiens	365-368
20119745-5	2010	In addition, the two mentioned compounds inhibit intracellular signalling mechanisms leading to apoptotic cell death, namely those mediated by mitochondria, which was confirmed by their ability to overcome t-BHP-induced morphological changes in the mitochondrial network, loss of mitochondrial membrane potential, increased expression of the pro-apoptotic proteins p53, Bax and AIF and activation of caspases-3 and -9.	tert-Butylhydroperoxide	206-211	BCL2 associated X, apoptosis regulator	Homo sapiens	370-373
20119745-5	2010	In addition, the two mentioned compounds inhibit intracellular signalling mechanisms leading to apoptotic cell death, namely those mediated by mitochondria, which was confirmed by their ability to overcome t-BHP-induced morphological changes in the mitochondrial network, loss of mitochondrial membrane potential, increased expression of the pro-apoptotic proteins p53, Bax and AIF and activation of caspases-3 and -9.	tert-Butylhydroperoxide	206-211	apoptosis inducing factor mitochondria associated 1	Homo sapiens	378-417
19693686-4	2010	The C. glabrata skn7 deletant showed increased susceptibility to hydrogen peroxide and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	87-111	kinase-regulated stress-responsive transcription factor SKN7	Saccharomyces cerevisiae S288C	16-20
20338726-7	2010	Similarly, cell shrinkage by 48 h replacement of extracellular chloride with gluconate and oxidative stress (30 min exposure to 0.3 mM tert-butylhydroperoxide) triggered suicidal erythrocyte death as evident from enhanced annexin V-binding.	tert-Butylhydroperoxide	135-158	annexin A5	Homo sapiens	222-231
20075041-6	2010	Deletion of tehB leads to an increase in sensitivity both to tellurite and to the oxidizing agents cumene hydroperoxide, tert-butyl hydroperoxide and hydrogen peroxide.	tert-Butylhydroperoxide	121-145	SAM-dependent methyltransferase TehB	Haemophilus influenzae Rd KW20	12-16
20100471-7	2010	OA ameliorated the oxidative injury induced by tBHP through increasing the generation of antioxidant (glutathione) and the expression of key antioxidant enzymes mediated by nuclear factorerythroid 2 p45-related factor 2 (Nrf2), in which process, activation of JNK and ERK, but not p38, was involved.	tert-Butylhydroperoxide	47-51	NFE2 like bZIP transcription factor 2	Homo sapiens	221-225
20004653-8	2010	Treatment of TBH (tert-butyl hydroperoxide) significantly increases cell death in the cells with mildly expanded TBP.	tert-Butylhydroperoxide	13-16	TATA-box binding protein	Homo sapiens	113-116
20004653-8	2010	Treatment of TBH (tert-butyl hydroperoxide) significantly increases cell death in the cells with mildly expanded TBP.	tert-Butylhydroperoxide	18-42	TATA-box binding protein	Homo sapiens	113-116
19962379-7	2010	We now confirm that exposure to oxidants induces lipoxidative modification of Na(V)1.5 and that the selective isoketal scavengers block voltage-dependent changes in sodium current by the oxidant tert-butylhydroperoxide, both in cells heterologously expressing Na(V)1.5 and in a mouse cardiac myocyte cell line (HL-1).	tert-Butylhydroperoxide	195-218	sodium channel, voltage-gated, type V, alpha	Mus musculus	78-86
19962379-7	2010	We now confirm that exposure to oxidants induces lipoxidative modification of Na(V)1.5 and that the selective isoketal scavengers block voltage-dependent changes in sodium current by the oxidant tert-butylhydroperoxide, both in cells heterologously expressing Na(V)1.5 and in a mouse cardiac myocyte cell line (HL-1).	tert-Butylhydroperoxide	195-218	sodium channel, voltage-gated, type V, alpha	Mus musculus	260-268
20198202-9	2010	The antioxidant effect of MSW on t-BHP-induced oxidative stress in HepG2 cells was supported by the increased activities of intracellular antioxidant enzymes such as catalase and glutathione reductase.	tert-Butylhydroperoxide	33-38	catalase	Homo sapiens	166-174
20198202-9	2010	The antioxidant effect of MSW on t-BHP-induced oxidative stress in HepG2 cells was supported by the increased activities of intracellular antioxidant enzymes such as catalase and glutathione reductase.	tert-Butylhydroperoxide	33-38	glutathione-disulfide reductase	Homo sapiens	179-200
20045930-4	2010	Using 4"-6-diamidino-2-phenylindole (DAPI)- or Hoechst 33342-staining and annexin V detection, we found that oxidative stress caused by tert-butyl hydroperoxide and proteasome inhibition by lactacystin induced apoptosis in neurons and astrocytes.	tert-Butylhydroperoxide	136-160	annexin A5	Rattus norvegicus	74-83
20110684-5	2010	The hydroperoxide donor TBHP increased SOD1 levels but did not change catalase levels.	tert-Butylhydroperoxide	24-28	superoxide dismutase 1	Homo sapiens	39-43
19591088-10	2010	These results suggest that sauchinone increases the cellular resistance of HepG2 cells to T-butyl hydroperoxide-induced oxidative injury, presumably through the p38 MAPK pathway-Nrf2/ARE-dependent HO-1 expression.	tert-Butylhydroperoxide	90-111	NFE2 like bZIP transcription factor 2	Homo sapiens	178-182
19762915-6	2009	In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation.	tert-Butylhydroperoxide	30-34	insulin receptor substrate 1	Homo sapiens	52-57
20508724-6	2010	GW9662 also suppressed UVB and tert-butylhydroperoxide- (TBH-) induced PGE(2) production in PHKs and intact human epidermis and partially inhibited UVB-induced COX-2 expression in PHKs.	tert-Butylhydroperoxide	31-54	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	160-165
20019877-8	2009	Cells treated with clusterin had higher viability than control cells at 5 mM tBHP.	tert-Butylhydroperoxide	77-81	clusterin	Homo sapiens	19-28
20019877-6	2009	Clusterin significantly inhibited tBHP-induced ROS production.	tert-Butylhydroperoxide	34-38	clusterin	Homo sapiens	0-9
20065498-5	2009	tBHP induced limited cytotoxicity, increased apoptosis, decreased glutamine synthetase and enolase activities, decreased nuclear CREB, CREB-P and histone proteins but unchanged cytosolic CREB and histone acetyltransferase (HDAC) expression.	tert-Butylhydroperoxide	0-4	glutamate-ammonia ligase	Rattus norvegicus	66-86
20065498-5	2009	tBHP induced limited cytotoxicity, increased apoptosis, decreased glutamine synthetase and enolase activities, decreased nuclear CREB, CREB-P and histone proteins but unchanged cytosolic CREB and histone acetyltransferase (HDAC) expression.	tert-Butylhydroperoxide	0-4	cAMP responsive element binding protein 1	Rattus norvegicus	129-133
20065498-5	2009	tBHP induced limited cytotoxicity, increased apoptosis, decreased glutamine synthetase and enolase activities, decreased nuclear CREB, CREB-P and histone proteins but unchanged cytosolic CREB and histone acetyltransferase (HDAC) expression.	tert-Butylhydroperoxide	0-4	cAMP responsive element binding protein 1	Rattus norvegicus	135-139
20065498-5	2009	tBHP induced limited cytotoxicity, increased apoptosis, decreased glutamine synthetase and enolase activities, decreased nuclear CREB, CREB-P and histone proteins but unchanged cytosolic CREB and histone acetyltransferase (HDAC) expression.	tert-Butylhydroperoxide	0-4	cAMP responsive element binding protein 1	Rattus norvegicus	135-139
19762915-6	2009	In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation.	tert-Butylhydroperoxide	30-34	mitogen-activated protein kinase 1	Homo sapiens	84-87
19762915-6	2009	In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation.	tert-Butylhydroperoxide	30-34	insulin like growth factor 1	Homo sapiens	118-123
19762915-6	2009	In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation.	tert-Butylhydroperoxide	30-34	insulin receptor substrate 1	Homo sapiens	132-137
19762915-6	2009	In normal human chondrocytes, tBHP triggered strong IRS-1 (Ser-312 and Ser-616) and ERK phosphorylation and inhibited IGF-I-induced IRS-1 (Tyr-612) and Akt phosphorylation.	tert-Butylhydroperoxide	30-34	AKT serine/threonine kinase 1	Homo sapiens	152-155
19762915-8	2009	CA Akt also promoted type II collagen and Sox9 expression, whereas tBHP treatment and CA MEK inhibited aggrecan, collagen II, and Sox9 mRNA expression.	tert-Butylhydroperoxide	67-71	SRY-box transcription factor 9	Homo sapiens	130-134
19762915-10	2009	Chemical inhibition of ERK significantly enhanced IGF-I phosphorylation of Akt and alleviated tBHP inhibition of Akt phosphorylation.	tert-Butylhydroperoxide	94-98	mitogen-activated protein kinase 1	Homo sapiens	23-26
19762915-10	2009	Chemical inhibition of ERK significantly enhanced IGF-I phosphorylation of Akt and alleviated tBHP inhibition of Akt phosphorylation.	tert-Butylhydroperoxide	94-98	AKT serine/threonine kinase 1	Homo sapiens	113-116
19548637-0	2009	Catalytic properties of cobalt(III)-oxo cubanes in the TBHP oxidation of benzylic alcohols.	tert-Butylhydroperoxide	55-59	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	31-34
19603178-9	2009	When challenged with oxidative stress (250 microM t-butylhydroperoxide), VEGF expression and secretion increases and the influence of the MAPK changes: While p38 still accounts for about 30% of the secretion, Erk shows a similar influence.	tert-Butylhydroperoxide	50-70	vascular endothelial growth factor A	Homo sapiens	73-77
19603178-9	2009	When challenged with oxidative stress (250 microM t-butylhydroperoxide), VEGF expression and secretion increases and the influence of the MAPK changes: While p38 still accounts for about 30% of the secretion, Erk shows a similar influence.	tert-Butylhydroperoxide	50-70	mitogen-activated protein kinase 1	Homo sapiens	138-142
19603178-9	2009	When challenged with oxidative stress (250 microM t-butylhydroperoxide), VEGF expression and secretion increases and the influence of the MAPK changes: While p38 still accounts for about 30% of the secretion, Erk shows a similar influence.	tert-Butylhydroperoxide	50-70	mitogen-activated protein kinase 14	Homo sapiens	158-161
19603178-9	2009	When challenged with oxidative stress (250 microM t-butylhydroperoxide), VEGF expression and secretion increases and the influence of the MAPK changes: While p38 still accounts for about 30% of the secretion, Erk shows a similar influence.	tert-Butylhydroperoxide	50-70	mitogen-activated protein kinase 1	Homo sapiens	209-212
19874709-2	2009	A radish phospholipid hydroperoxide glutathione peroxidase (RsPHGPx) known to have high catalytic activity was applied to mouse 3T3 fibroblasts to determine the protective effects of PHGPx against oxidative injury triggered by hydroperoxides such as hydrogen peroxide (H(2)O(2)), tert-butyl hydroperoxide (t-BHP) and phosphatidylcholine hydroperoxide (PCOOH).	tert-Butylhydroperoxide	280-304	glutathione peroxidase 4	Mus musculus	62-67
19874709-2	2009	A radish phospholipid hydroperoxide glutathione peroxidase (RsPHGPx) known to have high catalytic activity was applied to mouse 3T3 fibroblasts to determine the protective effects of PHGPx against oxidative injury triggered by hydroperoxides such as hydrogen peroxide (H(2)O(2)), tert-butyl hydroperoxide (t-BHP) and phosphatidylcholine hydroperoxide (PCOOH).	tert-Butylhydroperoxide	306-311	glutathione peroxidase 4	Mus musculus	62-67
19647727-4	2009	Pretreatment of Hepa1c1c7 cells with CDCQ significantly reduced t-BHP-induced generation of ROS, caspase-3 activation, and subsequent cell death.	tert-Butylhydroperoxide	64-69	caspase 3	Mus musculus	97-106
19664004-3	2009	In particular, melatonin (10(-4)-10(-6) m) fully prevented myotube death induced by tert-butylhydroperoxide (t-BHP; 10 microm-24 hr) as assessed by acid phosphatase, caspase-3 activities and cellular morphological changes.	tert-Butylhydroperoxide	109-114	caspase 3	Mus musculus	166-175
19706404-4	2009	Knockdown of OLA1 in human cells elicited an increased resistance to oxidizing agents including tert-butyl hydroperoxide (tBH) and diamide without affecting cell proliferation, baseline apoptosis, or sensitivity to other cytotoxic agents that target the mitochondria, cytoskeleton, or DNA.	tert-Butylhydroperoxide	96-120	Obg like ATPase 1	Homo sapiens	13-17
19706404-4	2009	Knockdown of OLA1 in human cells elicited an increased resistance to oxidizing agents including tert-butyl hydroperoxide (tBH) and diamide without affecting cell proliferation, baseline apoptosis, or sensitivity to other cytotoxic agents that target the mitochondria, cytoskeleton, or DNA.	tert-Butylhydroperoxide	122-125	Obg like ATPase 1	Homo sapiens	13-17
19706404-5	2009	Conversely, overexpression of OLA1 increased cellular sensitivity to tBH and diamide.	tert-Butylhydroperoxide	69-72	Obg like ATPase 1	Homo sapiens	30-34
19706404-8	2009	Moreover, when de novo protein synthesis was blocked by cycloheximide in OLA1-knockdown cells, they continued to demonstrate increased resistance to both tBH and diamide.	tert-Butylhydroperoxide	154-157	Obg like ATPase 1	Homo sapiens	73-77
19415410-8	2009	GPx1 activity in red blood cells was measured by the spectrophotometric method by Paglia and Valentine, using t-butylhydroperoxide as the substrate.	tert-Butylhydroperoxide	110-130	glutathione peroxidase 1	Homo sapiens	0-4
19271990-5	2009	Moreover, mechanistic studies demonstrated that tBHP treatment led to a prolonged decrease in cytosolic ferritins levels in MtFt-expressing cells, while ferritin levels recovered to basal levels in control counterparts.	tert-Butylhydroperoxide	48-52	ferritin mitochondrial	Homo sapiens	124-128
19271990-6	2009	tBHP treatment also resulted in elevated transferrin receptors, followed by more iron acquisition in MtFt expressing cells.	tert-Butylhydroperoxide	0-4	ferritin mitochondrial	Homo sapiens	101-105
19843789-9	2009	The volatile anesthetics isoflurane, sevoflurane, and desflurane at concentrations from 1% to 3% attenuated the tert-butyl hydroperoxide-reduced EAAT3 activity for L-glutamate and L-cysteine.	tert-Butylhydroperoxide	112-136	solute carrier family 1 member 1	Rattus norvegicus	145-150
19631743-9	2009	To examine the effects of corticosterone on GT1-7 cell physiology, we incubated GT1-7 cells with t-butyl hydroperoxide (t-BuOOH) with corticosterone.	tert-Butylhydroperoxide	97-118	retinoic acid induced 1	Mus musculus	80-83
20442823-1	2009	OBJECTIVE: To study the mechanism involved in hydrogen peroxide (H(2)O(2)) or tert-butyl hydroperoxide (t-BHP)-induced potentiation of the Ang II-mediated contraction of isolated rat thoracic aorta.	tert-Butylhydroperoxide	78-102	angiogenin	Rattus norvegicus	139-142
19277051-6	2009	Heme-HPX complexes induce HO1 and, consequently, protect primary neurons against the toxicity of both heme and pro-oxidant tert-butyl hydroperoxide; such protection was decreased in HO1(-/-) neuronal cultures.	tert-Butylhydroperoxide	123-147	hemopexin	Mus musculus	5-8
19277051-6	2009	Heme-HPX complexes induce HO1 and, consequently, protect primary neurons against the toxicity of both heme and pro-oxidant tert-butyl hydroperoxide; such protection was decreased in HO1(-/-) neuronal cultures.	tert-Butylhydroperoxide	123-147	heme oxygenase 1	Mus musculus	182-185
19651802-5	2009	Treatments of beta-C or the combination of two antioxidants at 50 ppm for 48 h enhanced cell proliferation (P < 0.05) compared to tBHP control.	tert-Butylhydroperoxide	133-137	colony stimulating factor 2 receptor subunit beta	Homo sapiens	14-20
20442823-11	2009	CONCLUSION: From the above-mentioned results, we can reasonably conclude that H(2)O(2) and t-BHP potentiated the contraction induced by the Ang II.	tert-Butylhydroperoxide	91-96	angiogenin	Rattus norvegicus	140-143
20442823-12	2009	H(2)O(2)-induced potentiation of Ang II response may be mediated through tyrosine kinase activation and t-BHP through the activation of cyclo-oxygenase enzyme.	tert-Butylhydroperoxide	104-109	angiogenin	Rattus norvegicus	33-36
19233942-9	2009	Knockdown of NRF2 increased mortality following tBOOH challenge, prevented significant upregulation of antioxidant genes following both tBOOH and BNF + ANF exposures, and exacerbated BNF + ANF-related deformities.	tert-Butylhydroperoxide	48-53	nfe2 like bZIP transcription factor 2a	Danio rerio	13-17
19233942-9	2009	Knockdown of NRF2 increased mortality following tBOOH challenge, prevented significant upregulation of antioxidant genes following both tBOOH and BNF + ANF exposures, and exacerbated BNF + ANF-related deformities.	tert-Butylhydroperoxide	136-141	nfe2 like bZIP transcription factor 2a	Danio rerio	13-17
21189566-11	2009	CONCLUSION: NF-kappa-iNOS-nitric oxide signalling pathway can mediated t-BHP induced apoptosis in MIN6 cells .	tert-Butylhydroperoxide	71-76	nitric oxide synthase 2, inducible	Mus musculus	21-25
19246646-6	2009	Treatment with tert-butyl hydroperoxide resulted in a significant increase in HOMC FN mRNA and protein expression levels.	tert-Butylhydroperoxide	15-39	fibronectin 1	Homo sapiens	83-85
20442823-1	2009	OBJECTIVE: To study the mechanism involved in hydrogen peroxide (H(2)O(2)) or tert-butyl hydroperoxide (t-BHP)-induced potentiation of the Ang II-mediated contraction of isolated rat thoracic aorta.	tert-Butylhydroperoxide	104-109	angiogenin	Rattus norvegicus	139-142
20442823-3	2009	To explore the probable mechanism of H(2)O(2) and t-BHP-induced potentiation of Ang II-mediated contractile response, different blockers such as losartan (AT(1) receptor blocker; 1 muM), catalase (H(2)O(2) scavenger; 500 U/ml), lercanidipine (L-type calcium channel blocker; 1 muM), geinistein (tyrosine kinase inhibitor; 100 muM), and indomethacin (cyclo-oxygenase inhibitor; 10 muM) were used.	tert-Butylhydroperoxide	50-55	angiogenin	Rattus norvegicus	80-83
19263279-4	2009	H(2)O(2)-mediated toxicity was decreased by NADC (as compared to controls), but increased slightly with NAC, whereas tBHP-mediated toxicity was decreased both by NAC and NADC.	tert-Butylhydroperoxide	117-121	synuclein alpha	Homo sapiens	162-165
18812229-7	2009	Both inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression were increased by tBH and reduced by both RES and SM pretreatments.	tert-Butylhydroperoxide	105-108	nitric oxide synthase 2	Homo sapiens	38-43
18979186-12	2009	p53, p21, and Bax also showed increased expression, whereas Bcl-2 expression remained unchanged in DEM treatments and increased significantly in both TBHP treatments.	tert-Butylhydroperoxide	150-154	B cell leukemia/lymphoma 2	Mus musculus	60-65
18979186-13	2009	Hence, the present study indicates the involvement and activation of various apoptotic factors, particularly Caspase 3 and 9 along with p53, in response to exposure of testicular cells to DEM and TBHP.	tert-Butylhydroperoxide	196-200	caspase 3	Mus musculus	109-118
18979186-13	2009	Hence, the present study indicates the involvement and activation of various apoptotic factors, particularly Caspase 3 and 9 along with p53, in response to exposure of testicular cells to DEM and TBHP.	tert-Butylhydroperoxide	196-200	transformation related protein 53, pseudogene	Mus musculus	136-139
18812229-7	2009	Both inducible nitric oxide synthase (NOS-2) and hemoxygenase-1 (HO-1) gene expression were increased by tBH and reduced by both RES and SM pretreatments.	tert-Butylhydroperoxide	105-108	heme oxygenase 1	Homo sapiens	49-69
19910681-8	2009	0.3 mM tert-butylhydroperoxide), energy depletion (48 h glucose removal) and isotonic cell shrinkage (48 h replacement of extracellular Cl(-) with gluconate) significantly increased annexin V-binding and decreased the forward scatter, effects significantly blunted in the presence of thymol 2.5 - 20 microg/ml.	tert-Butylhydroperoxide	7-30	annexin A5	Homo sapiens	182-191
18640112-6	2008	The antioxidant, N-acetyl-L-cysteine (NAC), and secreted soluble mediators of RPE cells were appropriate to attenuate the effects of tBH-mediated oxidative stress.	tert-Butylhydroperoxide	133-136	X-linked Kx blood group	Homo sapiens	38-41
18787061-3	2008	In this study, we demonstrated that decreased canalicular expression of Mrp2 induced by tertiary-butyl hydroperoxide (t-BHP) was recovered to the canalicular membrane by the replenishment of GSH by GSH-ethyl ester, a cell-permeable form of GSH.	tert-Butylhydroperoxide	88-116	ATP binding cassette subfamily C member 2	Rattus norvegicus	72-76
18787061-3	2008	In this study, we demonstrated that decreased canalicular expression of Mrp2 induced by tertiary-butyl hydroperoxide (t-BHP) was recovered to the canalicular membrane by the replenishment of GSH by GSH-ethyl ester, a cell-permeable form of GSH.	tert-Butylhydroperoxide	118-123	ATP binding cassette subfamily C member 2	Rattus norvegicus	72-76
18824057-2	2008	Pretreatment with AC prior to the administration of t-BHP significantly prevented the increase in serum levels of hepatic enzyme markers (ALT, AST) and lipid peroxidation and reduced oxidative stress, as measured by glutathione content, in the liver.	tert-Butylhydroperoxide	52-57	glutamic pyruvic transaminase, soluble	Mus musculus	138-141
18824057-2	2008	Pretreatment with AC prior to the administration of t-BHP significantly prevented the increase in serum levels of hepatic enzyme markers (ALT, AST) and lipid peroxidation and reduced oxidative stress, as measured by glutathione content, in the liver.	tert-Butylhydroperoxide	52-57	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	143-146
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	71-95	estrogen receptor 1	Homo sapiens	136-138
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	71-95	AKT serine/threonine kinase 1	Homo sapiens	161-164
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	71-95	heme oxygenase 1	Homo sapiens	169-185
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	71-95	heme oxygenase 1	Homo sapiens	187-191
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	97-102	estrogen receptor 1	Homo sapiens	136-138
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	97-102	AKT serine/threonine kinase 1	Homo sapiens	161-164
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	97-102	heme oxygenase 1	Homo sapiens	169-185
18845176-4	2008	In this study, we demonstrate that the phytoestrogen puerarin inhibits tert-butyl hydroperoxide (t-BHP)-induced oxidative injury via an ER-dependent Gbeta1/PI3K/Akt and heme oxygenase-1 (HO-1) pathway.	tert-Butylhydroperoxide	97-102	heme oxygenase 1	Homo sapiens	187-191
18845176-5	2008	Pretreatment of Hepa1c1c7 and HepG2 cells with puerarin significantly reduced t-BHP-induced caspase-3 activation and subsequent cell death.	tert-Butylhydroperoxide	78-83	caspase 3	Homo sapiens	92-101
18845176-6	2008	Also, puerarin up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-BHP.	tert-Butylhydroperoxide	125-130	heme oxygenase 1	Homo sapiens	28-32
18926903-4	2008	However, on tert-butylhydroperoxide challenge, insulin-treated cells demonstrated a robust GSH recovery that was attributed to a greater capacity for de novo synthesis via elevated GCLc levels.	tert-Butylhydroperoxide	12-35	insulin	Homo sapiens	47-54
18640112-7	2008	RPE cells exposed to tBH were found to release increasing amounts of bFGF but not VEGF after 24h of culture, thereby supporting proliferation of CECs.	tert-Butylhydroperoxide	21-24	fibroblast growth factor 2	Homo sapiens	69-73
18478184-0	2008	Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages.	tert-Butylhydroperoxide	127-151	C-C motif chemokine ligand 5	Rattus norvegicus	69-75
18971612-7	2008	RESULTS: When treated with tBHP, the deformability of erythrocytes was decreased (P<0.01) and methemoglobin (metHb) formation and mean corpuscular volume (MCV) of erythrocytes were increased (P<0.01, P<0.05) compared to those of the untreated control cells.	tert-Butylhydroperoxide	27-31	hemoglobin subunit gamma 2	Homo sapiens	97-110
18478184-0	2008	Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages.	tert-Butylhydroperoxide	127-151	C-C motif chemokine ligand 2	Rattus norvegicus	77-82
18478184-0	2008	Salicylideneamino-2-thiophenol inhibits inflammatory mediator genes (RANTES, MCP-1, IL-8 and HIF-1alpha) expression induced by tert-butyl hydroperoxide via MAPK pathways in rat peritoneal macrophages.	tert-Butylhydroperoxide	127-151	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	93-103
18478184-7	2008	Sal thus has a protective effect against t-BHP-induced inflammation and that this, in part, is due to the inhibition of the production of RANTES, MCP-1, IL-8 and HIF-1alpha via the modulation of the NF-kappaB and mitogen-activated protein kinase (MAPK) pathways.	tert-Butylhydroperoxide	41-46	C-C motif chemokine ligand 5	Rattus norvegicus	138-144
18478184-7	2008	Sal thus has a protective effect against t-BHP-induced inflammation and that this, in part, is due to the inhibition of the production of RANTES, MCP-1, IL-8 and HIF-1alpha via the modulation of the NF-kappaB and mitogen-activated protein kinase (MAPK) pathways.	tert-Butylhydroperoxide	41-46	C-C motif chemokine ligand 2	Rattus norvegicus	146-151
18478184-7	2008	Sal thus has a protective effect against t-BHP-induced inflammation and that this, in part, is due to the inhibition of the production of RANTES, MCP-1, IL-8 and HIF-1alpha via the modulation of the NF-kappaB and mitogen-activated protein kinase (MAPK) pathways.	tert-Butylhydroperoxide	41-46	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	162-172
18485557-2	2008	In the present work, we investigated the protective effects of the phenethyl ester of caffeic acid (CAPE), an active component of honeybee propolis, on tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in a cultured HepG2 cell line and in rat liver.	tert-Butylhydroperoxide	152-176	structural maintenance of chromosomes 2	Homo sapiens	100-104
18619952-10	2008	Thus tBHP induced oxidative stress subject testicular cells to apoptosis which seems to involve p53.	tert-Butylhydroperoxide	5-9	transformation related protein 53, pseudogene	Mus musculus	96-99
18622456-0	2008	Me2Zn mediated, tert-butylhydroperoxide promoted, catalytic enantioselective Reformatsky reaction with aldehydes.	tert-Butylhydroperoxide	16-39	malic enzyme 2	Homo sapiens	0-3
18485557-4	2008	Furthermore, CAPE protected HepG2 cells against t-BHP-induced oxidative DNA damage, as determined by the Comet assay.	tert-Butylhydroperoxide	48-53	structural maintenance of chromosomes 2	Homo sapiens	13-17
18824057-7	2008	Taken together, these results suggest that the protective effects of AC against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and to regulate the antioxidant enzyme HO-1 via the ERK1/2 and p38/Nrf2 signaling pathways.	tert-Butylhydroperoxide	80-85	heme oxygenase 1	Mus musculus	209-213
18824057-7	2008	Taken together, these results suggest that the protective effects of AC against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and to regulate the antioxidant enzyme HO-1 via the ERK1/2 and p38/Nrf2 signaling pathways.	tert-Butylhydroperoxide	80-85	mitogen-activated protein kinase 3	Mus musculus	222-228
18824057-7	2008	Taken together, these results suggest that the protective effects of AC against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and to regulate the antioxidant enzyme HO-1 via the ERK1/2 and p38/Nrf2 signaling pathways.	tert-Butylhydroperoxide	80-85	mitogen-activated protein kinase 14	Mus musculus	233-236
18824057-7	2008	Taken together, these results suggest that the protective effects of AC against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and to regulate the antioxidant enzyme HO-1 via the ERK1/2 and p38/Nrf2 signaling pathways.	tert-Butylhydroperoxide	80-85	nuclear factor, erythroid derived 2, like 2	Mus musculus	237-241
18704329-6	2008	In addition, SMP30 transfected P19 cells were more protective to tert-butylhydroperoxide induced cytotoxicity, indicating the antioxidative properties of SMP30.	tert-Butylhydroperoxide	65-88	regucalcin	Homo sapiens	13-18
18485557-2	2008	In the present work, we investigated the protective effects of the phenethyl ester of caffeic acid (CAPE), an active component of honeybee propolis, on tert-butyl hydroperoxide (t-BHP)-induced hepatotoxicity in a cultured HepG2 cell line and in rat liver.	tert-Butylhydroperoxide	178-183	structural maintenance of chromosomes 2	Homo sapiens	100-104
18485557-6	2008	Our in vivo study showed that pretreatment with CAPE prior to the administration of t-BHP significantly and dose-dependently prevented increases in the serum levels of hepatic enzyme markers (alanine aminotransferase and aspartate aminotransferase) and reduced lipid peroxidation in rat liver.	tert-Butylhydroperoxide	84-89	structural maintenance of chromosomes 2	Rattus norvegicus	48-52
18485557-3	2008	CAPE was found to significantly reduce t-BHP-induced oxidative injury in HepG2 cells, as determined by cell cytotoxicity, and lipid peroxidation and reactive oxygen species (ROS) levels in a dose-dependent manner.	tert-Butylhydroperoxide	39-44	structural maintenance of chromosomes 2	Homo sapiens	0-4
18485557-7	2008	Moreover, histopathological evaluation of livers consistently revealed that CAPE reduced liver lesion induction by t-BHP.	tert-Butylhydroperoxide	115-120	structural maintenance of chromosomes 2	Homo sapiens	76-80
18485557-8	2008	Taken together, these results suggest that the protective effects of CAPE against t-BHP-induced hepatotoxicity may, at least in part, be due to its ability to scavenge ROS and protect DNA from oxidative stress-induced damage.	tert-Butylhydroperoxide	82-87	structural maintenance of chromosomes 2	Homo sapiens	69-73
17369293-2	2007	We have now studied the ability of oxidative stress induced by a synthetic oxidant tert-butyl hydroperoxide (tBHP) to induce TNF-alpha production via calcium signaling in the mouse macrophage cell line (J774).	tert-Butylhydroperoxide	83-107	tumor necrosis factor	Mus musculus	125-134
18398221-6	2008	At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	264-288	patatin like phospholipase domain containing 8	Homo sapiens	30-42
18490962-8	2008	Reactive oxygen species, induced by tert-butyl hydroperoxide, lead to P2X7 receptor activation on retinal pigment epithelium.	tert-Butylhydroperoxide	36-60	purinergic receptor P2X 7	Homo sapiens	70-83
18329388-4	2008	Using a siRNA approach, we showed that IGFBP-3 regulates the appearance of several biomarkers of senescence after repeated exposures of WI-38 fibroblasts to tert-butylhydroperoxide and ethanol.	tert-Butylhydroperoxide	157-180	insulin like growth factor binding protein 3	Homo sapiens	39-46
18316105-0	2008	Implication of caspases and subcellular compartments in tert-butylhydroperoxide induced apoptosis.	tert-Butylhydroperoxide	56-79	caspase 9	Homo sapiens	15-23
18316105-4	2008	Freshly isolated hepatocytes were exposed to 0.4 mM t-BHP during 1 h. A general caspase inhibitor, Boc-D-FMK, reduced t-BHP-induced apoptosis (chromatin condensation), confirming the involvement of caspases in apoptosis.	tert-Butylhydroperoxide	52-57	caspase 9	Homo sapiens	80-87
18316105-4	2008	Freshly isolated hepatocytes were exposed to 0.4 mM t-BHP during 1 h. A general caspase inhibitor, Boc-D-FMK, reduced t-BHP-induced apoptosis (chromatin condensation), confirming the involvement of caspases in apoptosis.	tert-Butylhydroperoxide	118-123	caspase 9	Homo sapiens	80-87
18316105-8	2008	Caspase-7 was translocated from the cytosol to the endoplasmic reticulum (ER), where it underwent processing; however, enzymatic activity of caspase-7 was inhibited by t-BHP.	tert-Butylhydroperoxide	168-173	caspase 7	Homo sapiens	0-9
18316105-8	2008	Caspase-7 was translocated from the cytosol to the endoplasmic reticulum (ER), where it underwent processing; however, enzymatic activity of caspase-7 was inhibited by t-BHP.	tert-Butylhydroperoxide	168-173	caspase 7	Homo sapiens	141-150
18278507-2	2008	We evaluated the expression of GRP-78 and its regulation by an oxidant tert-butyl hydroperoxide (tBH) in human retinal pigment epithelium (RPE) cells.	tert-Butylhydroperoxide	71-95	heat shock protein family A (Hsp70) member 5	Homo sapiens	31-37
18278507-2	2008	We evaluated the expression of GRP-78 and its regulation by an oxidant tert-butyl hydroperoxide (tBH) in human retinal pigment epithelium (RPE) cells.	tert-Butylhydroperoxide	97-100	heat shock protein family A (Hsp70) member 5	Homo sapiens	31-37
18278507-4	2008	The effects of tBH (10-100 microM) on GRP-78 and on growth arrest and DNA damage inducible genes 153 (GADD153) protein and mRNA expression were studied using Western blot and real-time polymerase chain reaction.	tert-Butylhydroperoxide	15-18	heat shock protein family A (Hsp70) member 5	Homo sapiens	38-44
18278507-8	2008	GRP-78 and GADD153 mRNA and protein expression in cultured RPE cells were significantly upregulated by treatment with tBH.	tert-Butylhydroperoxide	118-121	heat shock protein family A (Hsp70) member 5	Homo sapiens	0-6
18278507-8	2008	GRP-78 and GADD153 mRNA and protein expression in cultured RPE cells were significantly upregulated by treatment with tBH.	tert-Butylhydroperoxide	118-121	DNA damage inducible transcript 3	Homo sapiens	11-18
18278507-9	2008	CONCLUSION: tBH increases oxidative stress, increases accumulation of ROS in the ER, and upregulates expression of GRP-78 and GADD153.	tert-Butylhydroperoxide	12-15	heat shock protein family A (Hsp70) member 5	Homo sapiens	115-121
18278507-9	2008	CONCLUSION: tBH increases oxidative stress, increases accumulation of ROS in the ER, and upregulates expression of GRP-78 and GADD153.	tert-Butylhydroperoxide	12-15	DNA damage inducible transcript 3	Homo sapiens	126-133
18237276-4	2008	The results of the present study support the inactivation of MTAP in the liver of bacterial LPS (lipopolysaccharide)-challenged mice as well as in HepG2 cells after exposure to t-butyl hydroperoxide.	tert-Butylhydroperoxide	177-198	methylthioadenosine phosphorylase	Mus musculus	61-65
18258604-5	2008	Myh and Ogg1 double knockout cells were more sensitive than wild type to oxidants (hydrogen peroxide and t-butyl hydroperoxide), but not to cis-platinum or gamma-irradiations.	tert-Butylhydroperoxide	105-126	mutY DNA glycosylase	Mus musculus	0-3
18258604-5	2008	Myh and Ogg1 double knockout cells were more sensitive than wild type to oxidants (hydrogen peroxide and t-butyl hydroperoxide), but not to cis-platinum or gamma-irradiations.	tert-Butylhydroperoxide	105-126	8-oxoguanine DNA-glycosylase 1	Mus musculus	8-12
18212057-4	2008	Oncogenic C-RAF decreased the percentage of apoptotic cells following treatment with staurosporine or the oxidative stress-inducing agent tert-butyl hydroperoxide.	tert-Butylhydroperoxide	138-162	v-raf-leukemia viral oncogene 1	Mus musculus	10-15
18375874-3	2008	The present study was aimed to investigate whether ginsenoside Rg1 can delay the premature senescence of WI-38 cells induced by t-BHP and to explore the underlying molecular mechanisms.	tert-Butylhydroperoxide	128-133	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	63-66
18375874-4	2008	First, Rg1 pretreatment markedly reversed senescent morphological changes in WI-38 cells induced by t-BHP.	tert-Butylhydroperoxide	100-105	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	7-10
18375874-5	2008	Second, t-BHP treatment alone resulted in an increase in the protein levels of P16 and P21, and a decline in intracellular adenosine 5"-triphosphate (ATP) level and mitochondrial complex IV activity.	tert-Butylhydroperoxide	8-13	cyclin dependent kinase inhibitor 2A	Homo sapiens	79-82
18375874-5	2008	Second, t-BHP treatment alone resulted in an increase in the protein levels of P16 and P21, and a decline in intracellular adenosine 5"-triphosphate (ATP) level and mitochondrial complex IV activity.	tert-Butylhydroperoxide	8-13	H3 histone pseudogene 16	Homo sapiens	87-90
18375874-7	2008	These data indicate that ginsenoside Rg1 has an anti-aging effect on t-BHP-induced premature senescence in WI-38 cells.	tert-Butylhydroperoxide	69-74	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	37-40
17493859-0	2008	Ultrasound promoted selective synthesis of 1,1"-binaphthyls catalyzed by Fe impregnated pillared Montmorillonite K10 in presence of TBHP as an oxidant.	tert-Butylhydroperoxide	132-136	keratin 10	Homo sapiens	113-116
18021765-10	2008	These results demonstrate that the expression of HO-1 by brazilin is mediated via the PI3K/Akt and ERK pathways, and this expression inhibits t-BHP-induced cell death in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells.	tert-Butylhydroperoxide	142-147	heme oxygenase 1	Homo sapiens	49-53
18021765-10	2008	These results demonstrate that the expression of HO-1 by brazilin is mediated via the PI3K/Akt and ERK pathways, and this expression inhibits t-BHP-induced cell death in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells.	tert-Butylhydroperoxide	142-147	AKT serine/threonine kinase 1	Homo sapiens	91-94
18021765-10	2008	These results demonstrate that the expression of HO-1 by brazilin is mediated via the PI3K/Akt and ERK pathways, and this expression inhibits t-BHP-induced cell death in House Ear Institute-Organ of Corti 1 (HEI-OC1) cells.	tert-Butylhydroperoxide	142-147	mitogen-activated protein kinase 1	Homo sapiens	99-102
18024956-7	2008	However, mouse embryonic fibroblasts derived from Pafah2(-/-) mice were more sensitive to tert-butylhydroperoxide treatment than those derived from wild-type mice.	tert-Butylhydroperoxide	90-113	platelet-activating factor acetylhydrolase 2	Mus musculus	50-56
18552516-13	2008	The mechanism of hyperoside protecting against ECV-304 cell apoptosis by TBHP is related with resuming mitochondrial function and regulating the expression of SIRT1 and Bcl-2 family members.	tert-Butylhydroperoxide	73-77	sirtuin 1	Homo sapiens	159-164
18552516-13	2008	The mechanism of hyperoside protecting against ECV-304 cell apoptosis by TBHP is related with resuming mitochondrial function and regulating the expression of SIRT1 and Bcl-2 family members.	tert-Butylhydroperoxide	73-77	BCL2 apoptosis regulator	Homo sapiens	169-174
18184479-4	2007	gamma-Cystathionase activity in fetal hepatocytes in vitro increased when incubated with tert-butyl-hydroperoxide at low concentration (0.01 mM).	tert-Butylhydroperoxide	89-113	cystathionine gamma-lyase	Rattus norvegicus	0-19
17869215-3	2007	Using the SB transposon system in vitro hTERT gene overexpression has protective effects from acute cellular injury by tert-butyl hydroperoxide (t-BH), carbon tetrachloride (CCl(4)), and d-galactosamine (d-GalN) in normal human cells IMR-90.	tert-Butylhydroperoxide	145-149	telomerase reverse transcriptase	Homo sapiens	40-45
17548047-3	2007	C93S-Trx2 enhanced sensitivity to cell death induced by tert-butylhydroperoxide or by tumor necrosis factor-alpha (TNF-alpha).	tert-Butylhydroperoxide	56-79	thioredoxin 2	Homo sapiens	5-9
17893648-4	2007	PRDX3 levels in human lens epithelial cells and whole rat lenses exposed to H2O2, TBHP, and heat-treatment were also examined relative to untreated controls by RT-PCR and western analysis.	tert-Butylhydroperoxide	82-86	peroxiredoxin 3	Homo sapiens	0-5
17893648-8	2007	Induction of PRDX3 was specific for H2O2 in cultured lens cells since sub-lethal levels of TBHP or heat-shock did not result in detectable increases in the level of PRDX3.	tert-Butylhydroperoxide	91-95	peroxiredoxin 3	Homo sapiens	13-18
17577742-2	2007	Cell adhesion onto vitronectin (Vn) and fibronectin (Fn) was increased at low concentrations of HX/XO (up to 5 mU/ml) or t-BHP (up to 125 microM) and prevented ROS-induced apoptosis.	tert-Butylhydroperoxide	121-126	vitronectin	Homo sapiens	19-30
17577742-2	2007	Cell adhesion onto vitronectin (Vn) and fibronectin (Fn) was increased at low concentrations of HX/XO (up to 5 mU/ml) or t-BHP (up to 125 microM) and prevented ROS-induced apoptosis.	tert-Butylhydroperoxide	121-126	vitronectin	Homo sapiens	32-34
17577742-2	2007	Cell adhesion onto vitronectin (Vn) and fibronectin (Fn) was increased at low concentrations of HX/XO (up to 5 mU/ml) or t-BHP (up to 125 microM) and prevented ROS-induced apoptosis.	tert-Butylhydroperoxide	121-126	fibronectin 1	Homo sapiens	40-51
17577742-2	2007	Cell adhesion onto vitronectin (Vn) and fibronectin (Fn) was increased at low concentrations of HX/XO (up to 5 mU/ml) or t-BHP (up to 125 microM) and prevented ROS-induced apoptosis.	tert-Butylhydroperoxide	121-126	fibronectin 1	Homo sapiens	53-55
17507167-6	2007	Translocation of Nrf2 into the nucleus was increased by the free-radical donor tert-butylhydroperoxide, but not by glutamate or N-methyl-D-aspartic acid (NMDA).	tert-Butylhydroperoxide	79-102	NFE2 like bZIP transcription factor 2	Homo sapiens	17-21
18398221-6	2008	At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	264-288	patatin like phospholipase domain containing 8	Homo sapiens	163-175
18398221-6	2008	At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	290-294	patatin like phospholipase domain containing 8	Homo sapiens	30-42
18398221-6	2008	At 48 h after exposure to the iPLA(2)gamma shRNA, uncoupled oxygen consumption was inhibited by 25% and apoptosis was observed at 72 and 96 h. RPTC with decreased iPLA(2)gamma expression underwent apoptosis when exposed to a nonlethal concentration of the oxidant tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	290-294	patatin like phospholipase domain containing 8	Homo sapiens	163-175
18398221-7	2008	Exposure of control cells to a nonlethal concentration of TBHP induced iPLA(2)gamma expression in RPTC.	tert-Butylhydroperoxide	58-62	patatin like phospholipase domain containing 8	Homo sapiens	71-83
18422870-4	2008	The protein is able to reduce H2O2 and tert-butyl hydroperoxide and is regenerated by both glutaredoxin (Grx) and thioredoxin (Trx) systems.	tert-Butylhydroperoxide	39-63	CAX interacting protein 1	Arabidopsis thaliana	91-103
18422870-4	2008	The protein is able to reduce H2O2 and tert-butyl hydroperoxide and is regenerated by both glutaredoxin (Grx) and thioredoxin (Trx) systems.	tert-Butylhydroperoxide	39-63	CAX interacting protein 1	Arabidopsis thaliana	105-108
18422870-4	2008	The protein is able to reduce H2O2 and tert-butyl hydroperoxide and is regenerated by both glutaredoxin (Grx) and thioredoxin (Trx) systems.	tert-Butylhydroperoxide	39-63	thioredoxin H-type 1	Arabidopsis thaliana	114-125
18422870-4	2008	The protein is able to reduce H2O2 and tert-butyl hydroperoxide and is regenerated by both glutaredoxin (Grx) and thioredoxin (Trx) systems.	tert-Butylhydroperoxide	39-63	thioredoxin H-type 1	Arabidopsis thaliana	127-130
18819471-6	2008	Furthermore, Ex-4 partly reduced the expression of iNOS protein and the ratio of NF-kappaBp65 protein in nucleus:cytosol induced by t-BHP.	tert-Butylhydroperoxide	132-137	nitric oxide synthase 2, inducible	Mus musculus	51-55
18702879-7	2008	The oxidative action induced by TBHP was observed in erythrocytes AA<AS<SS, by the increase in the content of Heinz bodies, methemoglobin, hemolysis, GSH depletion and lowering activities of the enzymes G6-PD and GR.	tert-Butylhydroperoxide	32-36	hemoglobin subunit gamma 2	Homo sapiens	130-143
18702879-7	2008	The oxidative action induced by TBHP was observed in erythrocytes AA<AS<SS, by the increase in the content of Heinz bodies, methemoglobin, hemolysis, GSH depletion and lowering activities of the enzymes G6-PD and GR.	tert-Butylhydroperoxide	32-36	glucose-6-phosphate dehydrogenase	Homo sapiens	209-214
18702879-8	2008	The protective actions of the vitamins C and E for the oxidative stress induced by TBHP were observed for the erythrocytes in the lowering Heinz bodies, methemoglobin, hemolysis, and partial recovery of GSH more efficiently in AS and SS erythrocytes.	tert-Butylhydroperoxide	83-87	hemoglobin subunit gamma 2	Homo sapiens	153-166
18417208-6	2008	Addition of either hydrogen-peroxide (H(2)O(2)) or tert-butyl hydroperoxide (tBHP) to the cis chamber (intracellular side) rapidly and completely inhibited PC2-mediated cation channel activity in reconstituted hST vesicles.	tert-Butylhydroperoxide	51-75	polycystin 2, transient receptor potential cation channel	Homo sapiens	156-159
18417208-6	2008	Addition of either hydrogen-peroxide (H(2)O(2)) or tert-butyl hydroperoxide (tBHP) to the cis chamber (intracellular side) rapidly and completely inhibited PC2-mediated cation channel activity in reconstituted hST vesicles.	tert-Butylhydroperoxide	51-75	sulfotransferase family 2A member 1	Homo sapiens	210-213
18417208-6	2008	Addition of either hydrogen-peroxide (H(2)O(2)) or tert-butyl hydroperoxide (tBHP) to the cis chamber (intracellular side) rapidly and completely inhibited PC2-mediated cation channel activity in reconstituted hST vesicles.	tert-Butylhydroperoxide	77-81	polycystin 2, transient receptor potential cation channel	Homo sapiens	156-159
18417208-6	2008	Addition of either hydrogen-peroxide (H(2)O(2)) or tert-butyl hydroperoxide (tBHP) to the cis chamber (intracellular side) rapidly and completely inhibited PC2-mediated cation channel activity in reconstituted hST vesicles.	tert-Butylhydroperoxide	77-81	sulfotransferase family 2A member 1	Homo sapiens	210-213
18226607-4	2008	After exposure to 8 mM tert-butylhydroperoxide (tert-BHP) for 1 h daily for 5 days, the cells showed four well-known senescence biomarkers: hypertrophy, senescence-associated beta-galactosidase activity, growth arrest, and cell cycle arrest in G1.	tert-Butylhydroperoxide	23-46	galactosidase beta 1	Homo sapiens	175-193
18226607-4	2008	After exposure to 8 mM tert-butylhydroperoxide (tert-BHP) for 1 h daily for 5 days, the cells showed four well-known senescence biomarkers: hypertrophy, senescence-associated beta-galactosidase activity, growth arrest, and cell cycle arrest in G1.	tert-Butylhydroperoxide	48-56	galactosidase beta 1	Homo sapiens	175-193
18666426-7	2008	It was found that genistein, at 1 microM, diminished t-BHP-induced down-regulation of the IGF-I receptor, Shc, Sos and phosphorylated ERK1/ERK2 expression in fibroblasts.	tert-Butylhydroperoxide	53-58	insulin like growth factor 1 receptor	Homo sapiens	90-104
18666426-7	2008	It was found that genistein, at 1 microM, diminished t-BHP-induced down-regulation of the IGF-I receptor, Shc, Sos and phosphorylated ERK1/ERK2 expression in fibroblasts.	tert-Butylhydroperoxide	53-58	SHC adaptor protein 1	Homo sapiens	106-109
18666426-7	2008	It was found that genistein, at 1 microM, diminished t-BHP-induced down-regulation of the IGF-I receptor, Shc, Sos and phosphorylated ERK1/ERK2 expression in fibroblasts.	tert-Butylhydroperoxide	53-58	mitogen-activated protein kinase 3	Homo sapiens	134-138
18666426-7	2008	It was found that genistein, at 1 microM, diminished t-BHP-induced down-regulation of the IGF-I receptor, Shc, Sos and phosphorylated ERK1/ERK2 expression in fibroblasts.	tert-Butylhydroperoxide	53-58	mitogen-activated protein kinase 1	Homo sapiens	139-143
18666426-9	2008	These results suggest that the mechanism of the protective effect of genistein on collagen biosynthesis in t-BHP-treated fibroblasts may be due to prevention of disturbances in the IGF-I receptor-mediated, ERK1/ERK2-associated signaling pathway evoked by the oxidant.	tert-Butylhydroperoxide	107-112	insulin like growth factor 1 receptor	Homo sapiens	181-195
18666426-9	2008	These results suggest that the mechanism of the protective effect of genistein on collagen biosynthesis in t-BHP-treated fibroblasts may be due to prevention of disturbances in the IGF-I receptor-mediated, ERK1/ERK2-associated signaling pathway evoked by the oxidant.	tert-Butylhydroperoxide	107-112	mitogen-activated protein kinase 3	Homo sapiens	206-210
18666426-9	2008	These results suggest that the mechanism of the protective effect of genistein on collagen biosynthesis in t-BHP-treated fibroblasts may be due to prevention of disturbances in the IGF-I receptor-mediated, ERK1/ERK2-associated signaling pathway evoked by the oxidant.	tert-Butylhydroperoxide	107-112	mitogen-activated protein kinase 1	Homo sapiens	211-215
17200984-9	2008	The in vitro exposure of human red blood cells to NAC increased the cellular low-molecular-weight thiol levels and retarded tert-butylhydroperoxide-induced cellular thiol depletion and membrane lipid peroxidation as well as effectively inhibited hypochlorous acid-induced erythrocyte lysis.	tert-Butylhydroperoxide	124-147	X-linked Kx blood group	Homo sapiens	50-53
17934699-7	2008	An increase in testicular mRNA levels of redox-regulated cjun (P = 0.008) and cfos (P = 0.0006) subunits of activator protein 1 (AP1) was observed after TBHP treatment.	tert-Butylhydroperoxide	153-157	jun proto-oncogene	Mus musculus	108-127
17934699-7	2008	An increase in testicular mRNA levels of redox-regulated cjun (P = 0.008) and cfos (P = 0.0006) subunits of activator protein 1 (AP1) was observed after TBHP treatment.	tert-Butylhydroperoxide	153-157	jun proto-oncogene	Mus musculus	129-132
18254244-1	2007	We have reported that the protective effect of Magnolol on TBHP-induced injury in human nonsmall lung cancer H460 cells is partially via a p53 dependent mechanism.	tert-Butylhydroperoxide	59-63	tumor protein p53	Homo sapiens	139-142
17600836-7	2007	Similarly, neuronal cultures derived from EP1-/- mice were more resistant (90.6 +/- 5.8% viability) to tert-butyl hydroperoxide-induced oxidative stress than neurons from WT mice (39.6 +/- 17.2% viability).	tert-Butylhydroperoxide	103-127	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	42-45
17295091-0	2007	Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol.	tert-Butylhydroperoxide	131-154	heme oxygenase 1	Homo sapiens	0-16
17295091-0	2007	Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol.	tert-Butylhydroperoxide	131-154	interleukin 11	Homo sapiens	21-35
17295091-2	2007	In the present work we found an increased mRNA and protein level of interleukin-11 and heme oxygenase-1 in premature senescence of WI-38 human diploid foetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol.	tert-Butylhydroperoxide	191-214	interleukin 11	Homo sapiens	68-82
17295091-2	2007	In the present work we found an increased mRNA and protein level of interleukin-11 and heme oxygenase-1 in premature senescence of WI-38 human diploid foetal lung fibroblasts induced by both tert-butylhydroperoxide and ethanol.	tert-Butylhydroperoxide	191-214	heme oxygenase 1	Homo sapiens	87-103
17295091-3	2007	We tested whether interleukin-11 and heme oxygenase-1 could protect against tert-butylhydroperoxide- or ethanol-induced premature senescence when stable overexpression was established using a retroviral vector-based transduction.	tert-Butylhydroperoxide	76-99	interleukin 11	Homo sapiens	18-32
17295091-3	2007	We tested whether interleukin-11 and heme oxygenase-1 could protect against tert-butylhydroperoxide- or ethanol-induced premature senescence when stable overexpression was established using a retroviral vector-based transduction.	tert-Butylhydroperoxide	76-99	heme oxygenase 1	Homo sapiens	37-53
17703737-0	2007	Protective effect of magnolol on TBHP-induced injury in H460 cells partially via a p53 dependent mechanism.	tert-Butylhydroperoxide	33-37	tumor protein p53	Homo sapiens	83-86
17382927-1	2007	The authors investigated the effects of propofol on EAAT3 (excitatory amino acid transporter 3) activity under oxidative stress induced by tert-butyl hydroperoxide (t-BHP), and the mediation of these effects by protein kinase C (PKC).	tert-Butylhydroperoxide	139-163	solute carrier family 1 member 1	Rattus norvegicus	52-57
17382927-1	2007	The authors investigated the effects of propofol on EAAT3 (excitatory amino acid transporter 3) activity under oxidative stress induced by tert-butyl hydroperoxide (t-BHP), and the mediation of these effects by protein kinase C (PKC).	tert-Butylhydroperoxide	139-163	solute carrier family 1 member 1	Rattus norvegicus	59-94
17382927-1	2007	The authors investigated the effects of propofol on EAAT3 (excitatory amino acid transporter 3) activity under oxidative stress induced by tert-butyl hydroperoxide (t-BHP), and the mediation of these effects by protein kinase C (PKC).	tert-Butylhydroperoxide	165-170	solute carrier family 1 member 1	Rattus norvegicus	52-57
17382927-3	2007	Exposure of these oocytes to t-BHP (1-20 mM) for 10 min dose-dependently decreased EAAT3 activity, and t-BHP (5 mM) significantly decreased the Vmax, but not the Km of EAAT3 for glutamate, and propofol (1-100 microM) dose-dependently reversed this t-BHP-attenuated EAAT3 activity.	tert-Butylhydroperoxide	29-34	solute carrier family 1 member 1	Rattus norvegicus	83-88
17382927-4	2007	Phorbol-12-myristate-13-acetate (a PKC activator), also abolished this t-BHP-induced reduction in EAAT3 activity, whereas staurosporine (a PKC inhibitor), significantly decreased EAAT3 activity.	tert-Butylhydroperoxide	71-76	solute carrier family 1 member 1	Rattus norvegicus	98-103
17382927-4	2007	Phorbol-12-myristate-13-acetate (a PKC activator), also abolished this t-BHP-induced reduction in EAAT3 activity, whereas staurosporine (a PKC inhibitor), significantly decreased EAAT3 activity.	tert-Butylhydroperoxide	71-76	solute carrier family 1 member 1	Rattus norvegicus	179-184
17369293-2	2007	We have now studied the ability of oxidative stress induced by a synthetic oxidant tert-butyl hydroperoxide (tBHP) to induce TNF-alpha production via calcium signaling in the mouse macrophage cell line (J774).	tert-Butylhydroperoxide	109-113	tumor necrosis factor	Mus musculus	125-134
17369293-3	2007	The oxidant tBHP significantly increased intracellular calcium and the release of TNF-alpha in J774 cells, an effect that was reduced to control levels by inhibition of calcium signaling with verapamil, BAPTA-AM, and W-7.	tert-Butylhydroperoxide	12-16	tumor necrosis factor	Mus musculus	82-91
17211854-4	2007	The protective effect of steatosis was significantly reversed by the inhibition of AMP-activated kinase (AMPK) since spheroids transfected with a kinase-dead AMPKalpha2 subunit, exhibited a significant increase in TBH-induced cytotoxicity when fat-loaded.	tert-Butylhydroperoxide	214-217	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	105-109
17211854-4	2007	The protective effect of steatosis was significantly reversed by the inhibition of AMP-activated kinase (AMPK) since spheroids transfected with a kinase-dead AMPKalpha2 subunit, exhibited a significant increase in TBH-induced cytotoxicity when fat-loaded.	tert-Butylhydroperoxide	214-217	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	158-168
17611289-2	2007	(nutmeg) against tert-butylhydroperoxide (t-BHP)-induced cytotoxicity in a human hepatoma cell line, HepG2.	tert-Butylhydroperoxide	42-47	telomerase reverse transcriptase	Homo sapiens	17-21
17253801-0	2007	Regioselective oxyfunctionalization of unactivated carbons in steroids by a model of cytochrome P-450: osmiumporphyrin complex/tert-butyl hydroperoxide system.	tert-Butylhydroperoxide	127-151	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	85-101
17116659-8	2007	The epidermal growth factor receptor (EGFR) was activated following TBHP exposure, and the EGFR inhibitor AG1478 blocked the up-regulation of PGC-1alpha.	tert-Butylhydroperoxide	68-72	epidermal growth factor receptor	Homo sapiens	4-36
17116659-8	2007	The epidermal growth factor receptor (EGFR) was activated following TBHP exposure, and the EGFR inhibitor AG1478 blocked the up-regulation of PGC-1alpha.	tert-Butylhydroperoxide	68-72	epidermal growth factor receptor	Homo sapiens	38-42
17116659-8	2007	The epidermal growth factor receptor (EGFR) was activated following TBHP exposure, and the EGFR inhibitor AG1478 blocked the up-regulation of PGC-1alpha.	tert-Butylhydroperoxide	68-72	PPARG coactivator 1 alpha	Homo sapiens	142-152
16446085-1	2007	The effect of the protein-bound polysaccharide extracted from Glaciecola polaris (PSG) was investigated in vitro in the protection of oxidatively-injured mouse macrophages stressed by tert-butyl hydroperoxide (tbOOH) or by oxidatively modified low-density lipoprotein (Ox-LDL).	tert-Butylhydroperoxide	184-208	pregnancy specific glycoprotein 16	Mus musculus	82-85
16446085-1	2007	The effect of the protein-bound polysaccharide extracted from Glaciecola polaris (PSG) was investigated in vitro in the protection of oxidatively-injured mouse macrophages stressed by tert-butyl hydroperoxide (tbOOH) or by oxidatively modified low-density lipoprotein (Ox-LDL).	tert-Butylhydroperoxide	210-215	pregnancy specific glycoprotein 16	Mus musculus	82-85
17571795-4	2007	The survival was lowered only by 14-MPDA in the TBHP-exposed sod2 mutant.	tert-Butylhydroperoxide	48-52	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	61-65
17092320-2	2006	In this screen, we identified an Arabidopsis late embryogenesis-abundant (LEA)-like protein, AtLEA5, which increased the tolerance of Deltayap1 cells to the oxidants H(2)O(2), diamide, menadione and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	199-223	senescence-associated gene 21	Arabidopsis thaliana	93-99
17476701-0	2007	The txl1+ gene from Schizosaccharomyces pombe encodes a new thioredoxin-like 1 protein that participates in the antioxidant defence against tert-butyl hydroperoxide.	tert-Butylhydroperoxide	140-164	thioredoxin like 1	Homo sapiens	4-8
17349922-7	2007	Consistently, treating T cells with the ROS-producer tert-butyl hydrogen peroxide (TBHP) greatly enhanced membrane raft formation, distribution of phospho-LAT into lipid rafts, and increased IL-2 production.	tert-Butylhydroperoxide	53-81	linker for activation of T cells	Homo sapiens	155-158
17349922-7	2007	Consistently, treating T cells with the ROS-producer tert-butyl hydrogen peroxide (TBHP) greatly enhanced membrane raft formation, distribution of phospho-LAT into lipid rafts, and increased IL-2 production.	tert-Butylhydroperoxide	53-81	interleukin 2	Homo sapiens	191-195
17349922-7	2007	Consistently, treating T cells with the ROS-producer tert-butyl hydrogen peroxide (TBHP) greatly enhanced membrane raft formation, distribution of phospho-LAT into lipid rafts, and increased IL-2 production.	tert-Butylhydroperoxide	83-87	linker for activation of T cells	Homo sapiens	155-158
17349922-7	2007	Consistently, treating T cells with the ROS-producer tert-butyl hydrogen peroxide (TBHP) greatly enhanced membrane raft formation, distribution of phospho-LAT into lipid rafts, and increased IL-2 production.	tert-Butylhydroperoxide	83-87	interleukin 2	Homo sapiens	191-195
17211673-6	2007	Both rrg-2 and os-2 single mutation slightly increased sensitivity to t-butyl hydroperoxide, and rrg-2 and hpt-1 mutations increased the os-2 mutant"s sensitivity.	tert-Butylhydroperoxide	70-91	Ccm1p	Saccharomyces cerevisiae S288C	5-10
17129690-3	2007	In this study, we examined the effect of the oxidant tert-butylhydroperoxide (tBHP) on mouse J774 macrophages and its ability to cause the release of the pro-inflammatory cytokine tumour necrosis factor alpha (TNF-alpha).	tert-Butylhydroperoxide	53-76	tumor necrosis factor	Mus musculus	210-219
17129690-3	2007	In this study, we examined the effect of the oxidant tert-butylhydroperoxide (tBHP) on mouse J774 macrophages and its ability to cause the release of the pro-inflammatory cytokine tumour necrosis factor alpha (TNF-alpha).	tert-Butylhydroperoxide	78-82	tumor necrosis factor	Mus musculus	210-219
17129690-8	2007	The production of TNF-alpha protein by J774 macrophages was mediated by a pathway involving calcium as addition of calcium antagonists inhibited the tBHP stimulated increase in the cytokine.	tert-Butylhydroperoxide	149-153	tumor necrosis factor	Mus musculus	18-27
17129690-9	2007	Inhibitors of both PDE1 and PDE4 completely prevented the tBHP stimulated TNF-alpha release suggesting that the cAMP pathway may be important in the oxidant induced signalling pathway leading to gene expression of pro-inflammatory cytokines.	tert-Butylhydroperoxide	58-62	tumor necrosis factor	Mus musculus	74-83
17348389-1	2007	We have demonstrated that hypochlorite (HOCI/OCl-) and hypobromite (HOBr/OBr-) can react with tert-butyl hydroperoxide with close rate constants (k(HOCl) = 10,8 M(-1) x s(1); k(HOBr) = 8,9 M(-1) x (s(-1)).	tert-Butylhydroperoxide	94-118	leptin receptor	Homo sapiens	69-72
17074835-8	2006	The grx3grx4 double mutant was highly sensitive to the oxidising agents hydrogen peroxide and t-butylhydroperoxide but not to diamide.	tert-Butylhydroperoxide	94-114	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	4-12
17115906-7	2006	By mixing either methemoglobin or human blood with tert-butyl hydroperoxide, we found that this technique can detect OR- generated in vitro.	tert-Butylhydroperoxide	51-75	hemoglobin subunit gamma 2	Homo sapiens	17-30
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	29-52	mitogen-activated protein kinase 3	Homo sapiens	122-128
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	29-52	mitogen-activated protein kinase 1	Homo sapiens	133-136
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	54-58	mitogen-activated protein kinase 3	Homo sapiens	122-128
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	54-58	mitogen-activated protein kinase 1	Homo sapiens	133-136
16936141-3	2006	Among the GTO genes, GTO2 shows the strongest induction of expression by agents such as diamide, 1-chloro-2,4-dinitrobenzene, tert-butyl hydroperoxide or cadmium, in a manner that is dependent on transcriptional factors Yap1 and/or Msn2/4.	tert-Butylhydroperoxide	126-150	S-glutathionyl-(chloro)hydroquinone reductase	Saccharomyces cerevisiae S288C	21-25
16936141-3	2006	Among the GTO genes, GTO2 shows the strongest induction of expression by agents such as diamide, 1-chloro-2,4-dinitrobenzene, tert-butyl hydroperoxide or cadmium, in a manner that is dependent on transcriptional factors Yap1 and/or Msn2/4.	tert-Butylhydroperoxide	126-150	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	220-224
16935471-9	2006	In subsequent experiments, we found that VC-IP suppressed the elevation of intracellular peroxide after UVB irradiation, and enhanced cellular tolerance against UVB and reactive oxygen species such as hydrogen peroxide and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	223-247	phospholipid phosphatase 3	Homo sapiens	41-46
16704919-0	2006	Tertiary-butyl hydroperoxide induced oxidative stress and male reproductive activity in mice: role of transcription factor NF-kappaB and testicular antioxidant enzymes.	tert-Butylhydroperoxide	0-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132
16704919-5	2006	An increase in testicular mRNA abundance of redox-regulated p50 and p65 subunits of NF-kappaB was observed after TBHP treatment.	tert-Butylhydroperoxide	113-117	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-63
16704919-5	2006	An increase in testicular mRNA abundance of redox-regulated p50 and p65 subunits of NF-kappaB was observed after TBHP treatment.	tert-Butylhydroperoxide	113-117	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	68-71
16704919-5	2006	An increase in testicular mRNA abundance of redox-regulated p50 and p65 subunits of NF-kappaB was observed after TBHP treatment.	tert-Butylhydroperoxide	113-117	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-93
16903848-4	2006	Exposure of astroglia to tert-butyl hydroperoxide, and hence oxidative stress, subsequently leads to a switching in mRNA from the classical membrane-bound T-AChE to a preferential increase in the splice variant for a soluble form, R-AChE, This change in expression is reflected in increased perinuclear and reduced cytoplasmic AChE staining of the insulted glial cells, with a concomitant and marked increase in extracellular secretion that peaks at 1 h post-treatment.	tert-Butylhydroperoxide	25-49	acetylcholinesterase	Rattus norvegicus	157-161
16880205-6	2006	As an antioxidant, induction of Prx I expression led to improved cell survival following treatment with oxLDL or tert-butyl hydroperoxide.	tert-Butylhydroperoxide	113-137	peroxiredoxin 1	Homo sapiens	32-37
17015273-3	2006	Hepatocyte-derived SeP prevented tert-butylhydroperoxide (t-BHP)-induced oxidative cell death of Ea.hy926 cells in a similar manner as did sodium selenite, counteracting a t-BHP-induced loss of cellular membrane integrity.	tert-Butylhydroperoxide	33-56	selenoprotein P	Homo sapiens	19-22
17015273-3	2006	Hepatocyte-derived SeP prevented tert-butylhydroperoxide (t-BHP)-induced oxidative cell death of Ea.hy926 cells in a similar manner as did sodium selenite, counteracting a t-BHP-induced loss of cellular membrane integrity.	tert-Butylhydroperoxide	58-63	selenoprotein P	Homo sapiens	19-22
17015273-3	2006	Hepatocyte-derived SeP prevented tert-butylhydroperoxide (t-BHP)-induced oxidative cell death of Ea.hy926 cells in a similar manner as did sodium selenite, counteracting a t-BHP-induced loss of cellular membrane integrity.	tert-Butylhydroperoxide	172-177	selenoprotein P	Homo sapiens	19-22
16903848-4	2006	Exposure of astroglia to tert-butyl hydroperoxide, and hence oxidative stress, subsequently leads to a switching in mRNA from the classical membrane-bound T-AChE to a preferential increase in the splice variant for a soluble form, R-AChE, This change in expression is reflected in increased perinuclear and reduced cytoplasmic AChE staining of the insulted glial cells, with a concomitant and marked increase in extracellular secretion that peaks at 1 h post-treatment.	tert-Butylhydroperoxide	25-49	acetylcholinesterase	Rattus norvegicus	233-237
16705147-3	2006	Sublethal injury produced by tert-butylhydroperoxide (TBHP) resulted in three- to fivefold increase in phosphorylation of ERK1/2 and p38 but not JNK.	tert-Butylhydroperoxide	54-58	mitogen-activated protein kinase 8	Homo sapiens	145-148
16705147-7	2006	In contrast, activation of ERK1/2 by expression of constitutively active MEK1 suppressed basal, uncoupled, and state 3 respirations in noninjured RPTC to the levels observed in TBHP-injured RPTC.	tert-Butylhydroperoxide	177-181	mitogen-activated protein kinase 3	Homo sapiens	27-33
16705147-7	2006	In contrast, activation of ERK1/2 by expression of constitutively active MEK1 suppressed basal, uncoupled, and state 3 respirations in noninjured RPTC to the levels observed in TBHP-injured RPTC.	tert-Butylhydroperoxide	177-181	mitogen-activated protein kinase kinase 1	Homo sapiens	73-77
16903848-4	2006	Exposure of astroglia to tert-butyl hydroperoxide, and hence oxidative stress, subsequently leads to a switching in mRNA from the classical membrane-bound T-AChE to a preferential increase in the splice variant for a soluble form, R-AChE, This change in expression is reflected in increased perinuclear and reduced cytoplasmic AChE staining of the insulted glial cells, with a concomitant and marked increase in extracellular secretion that peaks at 1 h post-treatment.	tert-Butylhydroperoxide	25-49	acetylcholinesterase	Rattus norvegicus	233-237
16673405-5	2006	Our results show that primary culture cortical neurons derived from Gpx4 transgenic mice, which had increased expression of Gpx4, had increased cell survival and reduced level of apoptosis after exposure to t-butyl hydroperoxide and hydrogen peroxide.	tert-Butylhydroperoxide	207-228	glutathione peroxidase 4	Mus musculus	68-72
16673405-5	2006	Our results show that primary culture cortical neurons derived from Gpx4 transgenic mice, which had increased expression of Gpx4, had increased cell survival and reduced level of apoptosis after exposure to t-butyl hydroperoxide and hydrogen peroxide.	tert-Butylhydroperoxide	207-228	glutathione peroxidase 4	Mus musculus	124-128
16716901-4	2006	Cytosolic Ca2+ and PKCalpha translocation to membrane, an indicator of PKCalpha activation, were also elevated by tBOOH (+100 and +79%, respectively, p < 0.05).	tert-Butylhydroperoxide	114-119	protein kinase C, alpha	Rattus norvegicus	19-27
16716901-4	2006	Cytosolic Ca2+ and PKCalpha translocation to membrane, an indicator of PKCalpha activation, were also elevated by tBOOH (+100 and +79%, respectively, p < 0.05).	tert-Butylhydroperoxide	114-119	protein kinase C, alpha	Rattus norvegicus	71-79
16716901-7	2006	tBOOH induced redistribution of the tight-junctional-associated protein ZO-1.	tert-Butylhydroperoxide	0-5	tight junction protein 1	Rattus norvegicus	72-76
16716901-9	2006	Furthermore, PKC inhibition and PKA activation not only prevented but also fully reversed tBOOH-induced blebbing.	tert-Butylhydroperoxide	90-95	protein kinase C, alpha	Rattus norvegicus	13-16
16308312-13	2006	Moreover, the protective effects of gallic acid on tert-butyl hydroperoxide-induced toxicity was partially blocked by p38 MAPK and PST-P inhibitors, further demonstrating that gallic acid attenuates oxidative stress through a pathway that involves p38 MAPK and PST-P.	tert-Butylhydroperoxide	51-75	mitogen-activated protein kinase 14	Homo sapiens	118-121
16709917-2	2006	The present study was carried out in order to establish the effect of the organic pro-oxidant, tert-butylhydroperoxide (tBHP), on the mobilisation of intracellular Ca2+ stores in isolated rat pancreatic acinar cells and the mechanisms underlying this effect.	tert-Butylhydroperoxide	120-124	telomerase reverse transcriptase	Rattus norvegicus	95-99
16308312-13	2006	Moreover, the protective effects of gallic acid on tert-butyl hydroperoxide-induced toxicity was partially blocked by p38 MAPK and PST-P inhibitors, further demonstrating that gallic acid attenuates oxidative stress through a pathway that involves p38 MAPK and PST-P.	tert-Butylhydroperoxide	51-75	sulfotransferase family 1A member 1	Homo sapiens	131-134
16308312-13	2006	Moreover, the protective effects of gallic acid on tert-butyl hydroperoxide-induced toxicity was partially blocked by p38 MAPK and PST-P inhibitors, further demonstrating that gallic acid attenuates oxidative stress through a pathway that involves p38 MAPK and PST-P.	tert-Butylhydroperoxide	51-75	mitogen-activated protein kinase 14	Homo sapiens	248-251
16308312-13	2006	Moreover, the protective effects of gallic acid on tert-butyl hydroperoxide-induced toxicity was partially blocked by p38 MAPK and PST-P inhibitors, further demonstrating that gallic acid attenuates oxidative stress through a pathway that involves p38 MAPK and PST-P.	tert-Butylhydroperoxide	51-75	sulfotransferase family 1A member 1	Homo sapiens	261-264
16402917-4	2006	Expression of MT2A (MT isoform 2A), but not MT1A or MT1B RNA, was significantly inducible by rotenone (up to 7-fold), t-BHP (t-butyl hydroperoxide; 5-fold) and CdCl2 (50-fold), but not ZnCl2.	tert-Butylhydroperoxide	118-123	metallothionein 2A	Homo sapiens	14-18
16632112-4	2006	We investigated the expression of SeP in human astrocytes and its involvement in the protection of these cells against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage.	tert-Butylhydroperoxide	119-143	selenoprotein P	Homo sapiens	34-37
16632112-4	2006	We investigated the expression of SeP in human astrocytes and its involvement in the protection of these cells against tert-butyl hydroperoxide (t-BHP)-induced oxidative damage.	tert-Butylhydroperoxide	145-150	selenoprotein P	Homo sapiens	34-37
16632112-7	2006	Preincubation of astrocytes with hepatocyte-derived SeP mimicks the protective effect of low-molecular-weight selenocompounds such as sodium selenite or selenomethionine against oxidative damage, shielding astrocytes from t-BHP-induced cytotoxicity.	tert-Butylhydroperoxide	222-227	selenoprotein P	Homo sapiens	52-55
16632112-9	2006	Furthermore, specific downregulation of SeP expression by small interfering RNA decreases cell viability of human astrocytes and makes them more susceptible to t-BHP-induced cytotoxicity.	tert-Butylhydroperoxide	160-165	selenoprotein P	Homo sapiens	40-43
16452108-4	2006	tBOOH-induced bile salt secretory failure was accompanied by internalization of the canalicular bile salt export pump (Bsep), and disarrangement of cytoskeletal F-actin.	tert-Butylhydroperoxide	0-5	ATP binding cassette subfamily B member 11	Rattus norvegicus	96-117
16452108-4	2006	tBOOH-induced bile salt secretory failure was accompanied by internalization of the canalicular bile salt export pump (Bsep), and disarrangement of cytoskeletal F-actin.	tert-Butylhydroperoxide	0-5	ATP binding cassette subfamily B member 11	Rattus norvegicus	119-123
16614071-6	2006	Furthermore, diminished CBS levels are associated with reduced cell viability in hepatoma cells challenged with tert-butyl hydroperoxide.	tert-Butylhydroperoxide	112-136	cystathionine beta-synthase	Homo sapiens	24-27
16636651-0	2006	The role of metallothionein IIa in defending lens epithelial cells against cadmium and TBHP induced oxidative stress.	tert-Butylhydroperoxide	87-91	metallothionein 2A	Homo sapiens	12-31
16636651-4	2006	Here, we examined the ability of metallothionein IIa (MTIIa) to protect human lens epithelial cells against cadmium and tertiary butyl hydroperoxide (TBHP)-induced oxidative stress.	tert-Butylhydroperoxide	150-154	metallothionein 2A	Homo sapiens	33-52
16636651-4	2006	Here, we examined the ability of metallothionein IIa (MTIIa) to protect human lens epithelial cells against cadmium and tertiary butyl hydroperoxide (TBHP)-induced oxidative stress.	tert-Butylhydroperoxide	150-154	metallothionein 2A	Homo sapiens	54-59
16636651-7	2006	In addition, expression levels of three other important antioxidant genes, heme oxygenase-1, thioredoxin reductase-1, and manganese superoxide dismutase were monitored by real-time RT-PCR following exposure to TBHP.	tert-Butylhydroperoxide	210-214	heme oxygenase 1	Homo sapiens	75-91
16636651-7	2006	In addition, expression levels of three other important antioxidant genes, heme oxygenase-1, thioredoxin reductase-1, and manganese superoxide dismutase were monitored by real-time RT-PCR following exposure to TBHP.	tert-Butylhydroperoxide	210-214	thioredoxin reductase 1	Homo sapiens	93-116
16636651-9	2006	The MTIIa over expressing cells were also significantly more resistant to TBHP treatment while control cells exhibited significant shrinking and rounding-up following 3-6 h TBHP treatment, no changes were observed in TBHP-treated over expressing cells.	tert-Butylhydroperoxide	74-78	metallothionein 2A	Homo sapiens	4-9
16636651-9	2006	The MTIIa over expressing cells were also significantly more resistant to TBHP treatment while control cells exhibited significant shrinking and rounding-up following 3-6 h TBHP treatment, no changes were observed in TBHP-treated over expressing cells.	tert-Butylhydroperoxide	173-177	metallothionein 2A	Homo sapiens	4-9
16636651-9	2006	The MTIIa over expressing cells were also significantly more resistant to TBHP treatment while control cells exhibited significant shrinking and rounding-up following 3-6 h TBHP treatment, no changes were observed in TBHP-treated over expressing cells.	tert-Butylhydroperoxide	173-177	metallothionein 2A	Homo sapiens	4-9
16636651-12	2006	In addition, TBHP induced the expression of MTIIa, heme oxygenase-1, thioredoxin reductase-1, and MnSOD in both normal and MTIIa over-expressed cell lines.	tert-Butylhydroperoxide	13-17	metallothionein 2A	Homo sapiens	44-49
16636651-12	2006	In addition, TBHP induced the expression of MTIIa, heme oxygenase-1, thioredoxin reductase-1, and MnSOD in both normal and MTIIa over-expressed cell lines.	tert-Butylhydroperoxide	13-17	heme oxygenase 1	Homo sapiens	51-67
16636651-12	2006	In addition, TBHP induced the expression of MTIIa, heme oxygenase-1, thioredoxin reductase-1, and MnSOD in both normal and MTIIa over-expressed cell lines.	tert-Butylhydroperoxide	13-17	thioredoxin reductase 1	Homo sapiens	69-92
16636651-12	2006	In addition, TBHP induced the expression of MTIIa, heme oxygenase-1, thioredoxin reductase-1, and MnSOD in both normal and MTIIa over-expressed cell lines.	tert-Butylhydroperoxide	13-17	superoxide dismutase 2	Homo sapiens	98-103
16636651-12	2006	In addition, TBHP induced the expression of MTIIa, heme oxygenase-1, thioredoxin reductase-1, and MnSOD in both normal and MTIIa over-expressed cell lines.	tert-Butylhydroperoxide	13-17	metallothionein 2A	Homo sapiens	123-128
16636651-13	2006	Interestingly the latter three genes were induced at 2-3 fold higher levels in TBHP-treated MTIIa over-expressing cells, compared to treated control cells (p=0.001, p=0.02, and p=0.01, respectively).	tert-Butylhydroperoxide	79-83	metallothionein 2A	Homo sapiens	92-97
16636651-14	2006	CONCLUSIONS: These data indicate that over-expression of MTIIa in human lens epithelial cells results in protection against cadmium and TBHP-induced oxidative stress.	tert-Butylhydroperoxide	136-140	metallothionein 2A	Homo sapiens	57-62
16402917-4	2006	Expression of MT2A (MT isoform 2A), but not MT1A or MT1B RNA, was significantly inducible by rotenone (up to 7-fold), t-BHP (t-butyl hydroperoxide; 5-fold) and CdCl2 (50-fold), but not ZnCl2.	tert-Butylhydroperoxide	125-146	metallothionein 2A	Homo sapiens	14-18
16402917-7	2006	Compared with control and MT1B-overexpressing cells, ROS production was significantly lower and cell viability higher in MT2A-overexpressing HeLa cells when ROS production was enhanced by treatment with t-BHP.	tert-Butylhydroperoxide	203-208	metallothionein 1B	Homo sapiens	26-30
16402917-7	2006	Compared with control and MT1B-overexpressing cells, ROS production was significantly lower and cell viability higher in MT2A-overexpressing HeLa cells when ROS production was enhanced by treatment with t-BHP.	tert-Butylhydroperoxide	203-208	metallothionein 2A	Homo sapiens	121-125
16126241-7	2006	Finally, some of the quercetin treatments prevented the significant increase of glutathione peroxidase, superoxide dismutase, glutathione reductase and catalase activities induced by tert-butyl hydroperoxide.	tert-Butylhydroperoxide	183-207	glutathione-disulfide reductase	Homo sapiens	126-147
16126241-7	2006	Finally, some of the quercetin treatments prevented the significant increase of glutathione peroxidase, superoxide dismutase, glutathione reductase and catalase activities induced by tert-butyl hydroperoxide.	tert-Butylhydroperoxide	183-207	catalase	Homo sapiens	152-160
16677110-2	2006	In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter, tert-butylhydroperoxide (t-BHP)-injected mouse, and (d) t-BHP-treated Ac2F cells.	tert-Butylhydroperoxide	212-235	regucalcin	Rattus norvegicus	40-45
16677110-2	2006	In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter, tert-butylhydroperoxide (t-BHP)-injected mouse, and (d) t-BHP-treated Ac2F cells.	tert-Butylhydroperoxide	237-242	regucalcin	Rattus norvegicus	40-45
16677110-2	2006	In the current study, the modulation of SMP30 gene expression was explored by (a) antioxidative calorie restriction (CR), (b) proinflammatory lipopolysaccharide (LPS), in aged rat, (c) oxidative stress promoter, tert-butylhydroperoxide (t-BHP)-injected mouse, and (d) t-BHP-treated Ac2F cells.	tert-Butylhydroperoxide	268-273	regucalcin	Rattus norvegicus	40-45
16677110-4	2006	Results showed that CR prevented the age-related decrease in SMP30 expression, and also showed that SMP30 gene expression and binding activities of sites 3 and 5 decreased with treatments of t-BHP or LPS.	tert-Butylhydroperoxide	191-196	regucalcin	Rattus norvegicus	100-105
16677110-5	2006	These findings were confirmed by the antioxidant NAC and ERK-specific inhibitor PD098059 that blunted decreased SMP30 gene expression and binding activity of sites 3 and 5 by t-BHP in Ac2F cell system.	tert-Butylhydroperoxide	175-180	Eph receptor B1	Rattus norvegicus	57-60
16677110-5	2006	These findings were confirmed by the antioxidant NAC and ERK-specific inhibitor PD098059 that blunted decreased SMP30 gene expression and binding activity of sites 3 and 5 by t-BHP in Ac2F cell system.	tert-Butylhydroperoxide	175-180	regucalcin	Rattus norvegicus	112-117
16120654-5	2006	Apo A-IV significantly decreased apoptosis produced by both TBH and diamide, and washout of A-IV before incubation with TBH and diamide did not eliminate its protective effect.	tert-Butylhydroperoxide	60-63	apolipoprotein A4	Homo sapiens	0-8
16469450-2	2006	Not all oxidants affect eEF-2, which is extremely sensitive to oxidative stress caused mainly by lipid peroxidant compounds such as cumene hydroperoxide and t-butyl hydroperoxide.	tert-Butylhydroperoxide	157-178	eukaryotic translation elongation factor 2	Homo sapiens	24-29
16364238-3	2006	Oxidation induced by tert-butyl hydroperoxide (t-BuOOH) of this free cysteine residue in HSA was observed in detail.	tert-Butylhydroperoxide	21-45	albumin	Homo sapiens	89-92
16482620-4	2006	RESULTS: PGG up-regulated HO-1 expression and this expression conferred cytoprotection against oxidative injury induced by t-butyl hydroperoxide.	tert-Butylhydroperoxide	123-144	heme oxygenase 1	Homo sapiens	26-30
16417216-5	2006	The present studies were designed to examine the effects of the oxidant tert-butylhydroperoxide (TBH) on PPARgamma activation and COX-2 expression in SZ95 sebocytes.	tert-Butylhydroperoxide	72-95	peroxisome proliferator activated receptor gamma	Homo sapiens	105-114
16417216-5	2006	The present studies were designed to examine the effects of the oxidant tert-butylhydroperoxide (TBH) on PPARgamma activation and COX-2 expression in SZ95 sebocytes.	tert-Butylhydroperoxide	97-100	peroxisome proliferator activated receptor gamma	Homo sapiens	105-114
16417216-7	2006	We next demonstrated that TBH increased PPARgamma reporter activity in SZ95 sebocytes.	tert-Butylhydroperoxide	26-29	peroxisome proliferator activated receptor gamma	Homo sapiens	40-49
16417216-8	2006	Increased COX-2 protein, mRNA expression, and prostaglandin E(2) (PGE(2)) production was observed after TBH or PPARgamma agonist treatment.	tert-Butylhydroperoxide	104-107	prostaglandin-endoperoxide synthase 2	Homo sapiens	10-15
16417216-9	2006	The ability of PPARgamma agonists and TBH to induce COX-2 expression and PGE(2) production was blocked by pretreatment with the specific PPARgamma antagonist GW9662.	tert-Butylhydroperoxide	38-41	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-57
16417216-9	2006	The ability of PPARgamma agonists and TBH to induce COX-2 expression and PGE(2) production was blocked by pretreatment with the specific PPARgamma antagonist GW9662.	tert-Butylhydroperoxide	38-41	peroxisome proliferator activated receptor gamma	Homo sapiens	137-146
16251189-13	2005	Although the redox state of Gpx2 was not affected by Ca2+, the Gpx2 level was markedly increased in the presence of both tert-butyl hydroperoxide and Ca2+.	tert-Butylhydroperoxide	121-145	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	63-67
16102883-7	2005	Allicin-treated cells and SLS-treated cells similarly showed an increased sensitivity to exogenously added tert-butyl hydroperoxide (t-BOOH), an organic peroxide that is detoxified by the action of AHP1.	tert-Butylhydroperoxide	107-131	thioredoxin peroxidase AHP1	Saccharomyces cerevisiae S288C	198-202
16162168-0	2005	Hepatoprotective effect of ginsenoside Rb1 and compound K on tert-butyl hydroperoxide-induced liver injury.	tert-Butylhydroperoxide	61-85	RB transcriptional corepressor 1	Mus musculus	39-42
16204963-0	2005	Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury.	tert-Butylhydroperoxide	94-118	Rh associated glycoprotein	Homo sapiens	87-90
16204963-4	2005	Intraperitoneally and orally administered 20(S)-ginsenoside Rh2 to t-BHP-injured mice significantly inhibited the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities.	tert-Butylhydroperoxide	67-72	Rh associated glycoprotein	Homo sapiens	60-63
16204963-4	2005	Intraperitoneally and orally administered 20(S)-ginsenoside Rh2 to t-BHP-injured mice significantly inhibited the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities.	tert-Butylhydroperoxide	67-72	glutamic pyruvic transaminase, soluble	Mus musculus	132-156
16204963-4	2005	Intraperitoneally and orally administered 20(S)-ginsenoside Rh2 to t-BHP-injured mice significantly inhibited the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities.	tert-Butylhydroperoxide	67-72	glutamic pyruvic transaminase, soluble	Mus musculus	158-161
16204963-4	2005	Intraperitoneally and orally administered 20(S)-ginsenoside Rh2 to t-BHP-injured mice significantly inhibited the increase of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities.	tert-Butylhydroperoxide	67-72	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	167-193
16204963-5	2005	Orally administered 20(S)-ginsenoside Rg3 also showed the inhibition against the increase of ALT and AST of t-BHP-induced mice.	tert-Butylhydroperoxide	108-113	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	101-104
16162168-9	2005	Nevertheless, both ginsenoside Rb1 and compound K significantly inhibited the increment of ALT and AST induced by t-BHP in mice, when it was orally administered.	tert-Butylhydroperoxide	114-119	RB transcriptional corepressor 1	Mus musculus	31-34
16162168-9	2005	Nevertheless, both ginsenoside Rb1 and compound K significantly inhibited the increment of ALT and AST induced by t-BHP in mice, when it was orally administered.	tert-Butylhydroperoxide	114-119	glutamic pyruvic transaminase, soluble	Mus musculus	91-94
16162168-9	2005	Nevertheless, both ginsenoside Rb1 and compound K significantly inhibited the increment of ALT and AST induced by t-BHP in mice, when it was orally administered.	tert-Butylhydroperoxide	114-119	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	99-102
16266270-1	2005	It was shown with the spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone that myeloperoxidase (MPO) in the presence of its substrates H2O2 and Cl- as well as activated neutrophils destroy tert-butyl hydroperoxide producing two adducts of O-centered radicals which were identified as peroxyl and alcoxyl radicals.	tert-Butylhydroperoxide	193-217	myeloperoxidase	Homo sapiens	100-103
16097939-6	2005	The oxidative processes induced by tBOOH in red blood cells can be described as follows: 1) rapid GSH oxidation (30-60 sec) by glutathione peroxidase; 2) formation of radicals in the reaction between tBOOH and cellular Hb, which are then immediately consumed in lipid peroxidation reactions; 3) generation of chemiluminescence by the radicals formed.	tert-Butylhydroperoxide	35-40	glutathione peroxidase 2	Homo sapiens	127-152
15980350-8	2005	The T-BHP induction region contains a sequence that resembles the YAP1-responsive element (YRE) in Saccharomyces cerevisiae.	tert-Butylhydroperoxide	4-9	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	66-70
16097939-6	2005	The oxidative processes induced by tBOOH in red blood cells can be described as follows: 1) rapid GSH oxidation (30-60 sec) by glutathione peroxidase; 2) formation of radicals in the reaction between tBOOH and cellular Hb, which are then immediately consumed in lipid peroxidation reactions; 3) generation of chemiluminescence by the radicals formed.	tert-Butylhydroperoxide	200-205	glutathione peroxidase 2	Homo sapiens	127-152
15983220-5	2005	Furthermore, exposure of intact HMEC-1 or primary endothelial cells from either human umbilical vein or bovine aorta to the oxidizing agent tert-butylhydroperoxide or to 30 mmol/l glucose triggered PTP opening, cytochrome c decompartmentalization, and cell death.	tert-Butylhydroperoxide	140-163	LOC104968582	Bos taurus	211-223
15611089-7	2005	Finally, overexpression of Mcl-1 protected HepG2 cells against apoptosis induced by tert-butyl hydroperoxide as shown by inhibition of caspase-3 activation and DNA fragmentation.	tert-Butylhydroperoxide	84-108	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	27-32
16266270-1	2005	It was shown with the spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone that myeloperoxidase (MPO) in the presence of its substrates H2O2 and Cl- as well as activated neutrophils destroy tert-butyl hydroperoxide producing two adducts of O-centered radicals which were identified as peroxyl and alcoxyl radicals.	tert-Butylhydroperoxide	193-217	myeloperoxidase	Homo sapiens	83-98
15879681-9	2005	Taken together, (+)-catechin inhibited tBHP-induced translocation of NF-kappaB to improve cellular survival.	tert-Butylhydroperoxide	39-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78
15806612-6	2005	Present experiments demonstrate that Ure2 possesses a far broader protection specificity, being required to avoid the toxic effects of As(III), As(V), Cr(III), Cr(VI), Se(IV), as well as Cd(II) and Ni(II), and to varying lesser degrees Co(II), Cu(II), Fe(II), Ag(I), Hg(II), cumene and t-butyl hydroperoxides.	tert-Butylhydroperoxide	286-308	glutathione peroxidase	Saccharomyces cerevisiae S288C	37-41
16028365-0	2005	Activation mechanisms of endothelial NF-kappaB, IKK, and MAP kinase by tert-butyl hydroperoxide.	tert-Butylhydroperoxide	71-95	nuclear factor kappa B subunit 1	Homo sapiens	37-46
16028365-3	2005	To better understand vascular abnormality, we set out to delineate the activation mechanism of nuclear factor kappa B (NF-kappaB) by t-BHP and the regulation of MAPK in endothelial cells.	tert-Butylhydroperoxide	133-138	nuclear factor kappa B subunit 1	Homo sapiens	95-117
16028365-3	2005	To better understand vascular abnormality, we set out to delineate the activation mechanism of nuclear factor kappa B (NF-kappaB) by t-BHP and the regulation of MAPK in endothelial cells.	tert-Butylhydroperoxide	133-138	nuclear factor kappa B subunit 1	Homo sapiens	119-128
16028365-4	2005	The results showed that t-BHP induces NF-kappaB activation by an inhibitor of kappaB (IkappaB) phosphorylation through IkappaB kinase (IKK) activation.	tert-Butylhydroperoxide	24-29	nuclear factor kappa B subunit 1	Homo sapiens	38-47
16028365-5	2005	Our data from this t-BHP study also showed increased p38 MAP kinase and ERK activity; however, interestingly, t-BHP showed no influence on JNK.	tert-Butylhydroperoxide	19-24	mitogen-activated protein kinase 1	Homo sapiens	53-56
16028365-5	2005	Our data from this t-BHP study also showed increased p38 MAP kinase and ERK activity; however, interestingly, t-BHP showed no influence on JNK.	tert-Butylhydroperoxide	19-24	mitogen-activated protein kinase 1	Homo sapiens	72-75
16028365-6	2005	Pretreatment with the p38 MAP kinase inhibitor, SB203580 and the ERK1/2 inhibitor, PD98059, prevented t-BHP-induced increases in p65 translocation, NF-kappaB luciferase activity, and phospho-IKKalpha/beta.	tert-Butylhydroperoxide	102-107	mitogen-activated protein kinase 1	Homo sapiens	22-25
16028365-6	2005	Pretreatment with the p38 MAP kinase inhibitor, SB203580 and the ERK1/2 inhibitor, PD98059, prevented t-BHP-induced increases in p65 translocation, NF-kappaB luciferase activity, and phospho-IKKalpha/beta.	tert-Butylhydroperoxide	102-107	mitogen-activated protein kinase 3	Homo sapiens	65-71
16028365-6	2005	Pretreatment with the p38 MAP kinase inhibitor, SB203580 and the ERK1/2 inhibitor, PD98059, prevented t-BHP-induced increases in p65 translocation, NF-kappaB luciferase activity, and phospho-IKKalpha/beta.	tert-Butylhydroperoxide	102-107	RELA proto-oncogene, NF-kB subunit	Homo sapiens	129-132
16028365-6	2005	Pretreatment with the p38 MAP kinase inhibitor, SB203580 and the ERK1/2 inhibitor, PD98059, prevented t-BHP-induced increases in p65 translocation, NF-kappaB luciferase activity, and phospho-IKKalpha/beta.	tert-Butylhydroperoxide	102-107	nuclear factor kappa B subunit 1	Homo sapiens	148-157
16028365-7	2005	Data suggested that t-BHP induces NF-kappaB activation through the IKK pathway, which involves p38 MAPK and ERK activation.	tert-Butylhydroperoxide	20-25	nuclear factor kappa B subunit 1	Homo sapiens	34-43
16028365-7	2005	Data suggested that t-BHP induces NF-kappaB activation through the IKK pathway, which involves p38 MAPK and ERK activation.	tert-Butylhydroperoxide	20-25	mitogen-activated protein kinase 1	Homo sapiens	95-98
16028365-7	2005	Data suggested that t-BHP induces NF-kappaB activation through the IKK pathway, which involves p38 MAPK and ERK activation.	tert-Butylhydroperoxide	20-25	mitogen-activated protein kinase 1	Homo sapiens	108-111
16028365-9	2005	The t-BHP-induced activation of NF-kappaB and MAPK could be a major player in vascular dysfunctions, as seen in oxidative stressed responses and the vascular inflammatory process.	tert-Butylhydroperoxide	4-9	nuclear factor kappa B subunit 1	Homo sapiens	32-41
23923577-1	2005	Treatment of bovine pulmonary artery smooth muscle microsomes with tert-butylhydroperoxide (t-buOOH) (300 microM) markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and enhanced Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake.	tert-Butylhydroperoxide	67-90	matrix metallopeptidase 2	Bos taurus	134-160
15728565-5	2005	Loss of mitochondrial membrane potential (Deltapsi(m)), release of cytochrome c, and activation of caspase 3 after tBH treatments all increased under the more oxidized conditions.	tert-Butylhydroperoxide	115-118	caspase 3	Homo sapiens	99-108
23923577-1	2005	Treatment of bovine pulmonary artery smooth muscle microsomes with tert-butylhydroperoxide (t-buOOH) (300 microM) markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and enhanced Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake.	tert-Butylhydroperoxide	67-90	matrix metallopeptidase 2	Bos taurus	162-167
23923577-1	2005	Treatment of bovine pulmonary artery smooth muscle microsomes with tert-butylhydroperoxide (t-buOOH) (300 microM) markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and enhanced Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake.	tert-Butylhydroperoxide	92-99	matrix metallopeptidase 2	Bos taurus	134-160
23923577-1	2005	Treatment of bovine pulmonary artery smooth muscle microsomes with tert-butylhydroperoxide (t-buOOH) (300 microM) markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and enhanced Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake.	tert-Butylhydroperoxide	92-99	matrix metallopeptidase 2	Bos taurus	162-167
23923577-5	2005	However, t-buOOH-triggered changes in MMP-2 activity, and ATP- and Na(+)-dependent Ca2+ uptake were not reversed upon pre-treatment of the microsomes with a low concentration of 5 microg/ml of TIMP-2, which on the contrary reversed MMP-2 (1 microg/ml)-mediated alteration on these parameters.	tert-Butylhydroperoxide	9-16	matrix metallopeptidase 2	Bos taurus	38-43
23923577-5	2005	However, t-buOOH-triggered changes in MMP-2 activity, and ATP- and Na(+)-dependent Ca2+ uptake were not reversed upon pre-treatment of the microsomes with a low concentration of 5 microg/ml of TIMP-2, which on the contrary reversed MMP-2 (1 microg/ml)-mediated alteration on these parameters.	tert-Butylhydroperoxide	9-16	TIMP metallopeptidase inhibitor 2	Bos taurus	193-199
23923577-5	2005	However, t-buOOH-triggered changes in MMP-2 activity, and ATP- and Na(+)-dependent Ca2+ uptake were not reversed upon pre-treatment of the microsomes with a low concentration of 5 microg/ml of TIMP-2, which on the contrary reversed MMP-2 (1 microg/ml)-mediated alteration on these parameters.	tert-Butylhydroperoxide	9-16	matrix metallopeptidase 2	Bos taurus	232-237
23923577-6	2005	The inhibition of Na(+)-dependent Ca2+ uptake by MMP-2 under t-buOOH treatment overpowered the stimulation of ATP-dependent Ca2+ uptake in the microsomes.	tert-Butylhydroperoxide	61-68	matrix metallopeptidase 2	Bos taurus	49-54
23923577-7	2005	Combined treatment of the microsomes with low doses of MMP-2 (0.5 microg/ml) and t-buOOH (100 microM) augmented Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake, but inhibited Na(+)-dependent Ca2+ uptake, compared to that elicited by either MMP-2 (0.5 microg/ml) or t-buOOH (100 microM).	tert-Butylhydroperoxide	81-88	matrix metallopeptidase 2	Bos taurus	245-250
23923577-7	2005	Combined treatment of the microsomes with low doses of MMP-2 (0.5 microg/ml) and t-buOOH (100 microM) augmented Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake, but inhibited Na(+)-dependent Ca2+ uptake, compared to that elicited by either MMP-2 (0.5 microg/ml) or t-buOOH (100 microM).	tert-Butylhydroperoxide	270-277	matrix metallopeptidase 2	Bos taurus	55-60
23923577-8	2005	Pre-treatment with TIMP-2 (50 microg/ml) reversed the effects of MMP-2 (0.5 microg/ml) and/or t-buOOH (100 microM).	tert-Butylhydroperoxide	94-101	TIMP metallopeptidase inhibitor 2	Bos taurus	19-25
23923577-9	2005	Although pre-treatment with 5 microg/ml of TIMP-2 reversed the effects produced by MMP-2 (0.5 microg/ml), but it did not inhibit the responses elicited by t-buOOH (300 microM) or t-buOOH (100 microM) plus MMP-2 (0.5 microg/ml) in the microsomes.	tert-Butylhydroperoxide	179-186	TIMP metallopeptidase inhibitor 2	Bos taurus	43-49
15840331-12	2005	FAK and vinculin expression in RPE cells decreased and their distribution were changed after the treatment of higher concentrations of TBH.	tert-Butylhydroperoxide	135-138	protein tyrosine kinase 2	Homo sapiens	0-3
15840331-12	2005	FAK and vinculin expression in RPE cells decreased and their distribution were changed after the treatment of higher concentrations of TBH.	tert-Butylhydroperoxide	135-138	vinculin	Homo sapiens	8-16
15589375-8	2005	Results indicate that the HO-1 and HO-2 cells are more resistant than controls to hemin and to the organic tert-butyl hydroperoxide, t-BuOOH.	tert-Butylhydroperoxide	107-131	heme oxygenase 1	Homo sapiens	26-39
16520297-5	2005	Racemic and S-LA were less effective than the R-isomer that was also protective in tertiary butyl hydroperoxide (TBHP)-damaged C6 glioma.	tert-Butylhydroperoxide	113-117	src-like adaptor	Rattus norvegicus	12-16
15849717-6	2005	A slight increase in the gene expression of Cu/Zn superoxide dismutase and catalase with 500 microM tert-butyl hydroperoxide and of catalase with 200 microM hydrogen peroxide was observed.	tert-Butylhydroperoxide	100-124	catalase	Homo sapiens	75-83
15496407-6	2004	Cell death induced by t-butylhydroperoxide and diquat was significantly less in murine embryonic fibroblasts from Tg(GPX4) mice compared with wild type mice.	tert-Butylhydroperoxide	22-42	glutathione peroxidase 4	Mus musculus	117-121
15569404-7	2004	RESULTS: Exposure of tBHP 100 micromol/L to neurons for 60 min resulted in DYm loss and cytochrome c release from mitochondria and subsequent activation of caspase-3 and PARP cleavation, and cell apoptosis.	tert-Butylhydroperoxide	21-25	dymeclin	Rattus norvegicus	75-78
15569404-7	2004	RESULTS: Exposure of tBHP 100 micromol/L to neurons for 60 min resulted in DYm loss and cytochrome c release from mitochondria and subsequent activation of caspase-3 and PARP cleavation, and cell apoptosis.	tert-Butylhydroperoxide	21-25	caspase 3	Rattus norvegicus	156-165
15371425-5	2004	Here we use steady-state kinetic methods to characterize the multisubstrate peroxidase activity of Ure2p using GSH with cumene hydroperoxide, hydrogen peroxide, or tert-butyl hydroperoxide as substrates.	tert-Butylhydroperoxide	164-188	glutathione peroxidase	Saccharomyces cerevisiae S288C	99-104
15382913-1	2004	A simple and effective catalytic method to construct propargylamine was developed by using copper bromide and tert-BuOOH via a combination of sp3 C-H bond and sp C-H bond activations followed by C-C bond formation.	tert-Butylhydroperoxide	110-120	surfactant protein C	Homo sapiens	159-163
23923577-10	2005	Treatment with TIMP-2 (5 microg/ml) inhibited MMP-2 (1 microg/ml) activity (assessed by [14C]-gelatin degradation), whereas treatment of t-buOOH (300 microM) with TIMP-2 (5 microg/ml) abolished the inhibitory effect of TIMP-2 (5 microg/ml) on MMP-2 (1 microg/ml) activity (assessed by [14C]-gelatin degradation).	tert-Butylhydroperoxide	137-144	TIMP metallopeptidase inhibitor 2	Bos taurus	163-169
23923577-10	2005	Treatment with TIMP-2 (5 microg/ml) inhibited MMP-2 (1 microg/ml) activity (assessed by [14C]-gelatin degradation), whereas treatment of t-buOOH (300 microM) with TIMP-2 (5 microg/ml) abolished the inhibitory effect of TIMP-2 (5 microg/ml) on MMP-2 (1 microg/ml) activity (assessed by [14C]-gelatin degradation).	tert-Butylhydroperoxide	137-144	TIMP metallopeptidase inhibitor 2	Bos taurus	163-169
23923577-11	2005	Overall, these results suggested that t-buOOH inactivated TIMP-2, the ambient inhibitor of MMP-2, leading to activation of the ambient proteinase, MMP-2 which subsequently stimulated Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake, but inhibited Na(+)-dependent Ca2+ uptake, resulting in a marked decrease in Ca2+ uptake in the microsomes.	tert-Butylhydroperoxide	38-45	TIMP metallopeptidase inhibitor 2	Bos taurus	58-64
23923577-11	2005	Overall, these results suggested that t-buOOH inactivated TIMP-2, the ambient inhibitor of MMP-2, leading to activation of the ambient proteinase, MMP-2 which subsequently stimulated Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake, but inhibited Na(+)-dependent Ca2+ uptake, resulting in a marked decrease in Ca2+ uptake in the microsomes.	tert-Butylhydroperoxide	38-45	matrix metallopeptidase 2	Bos taurus	91-96
23923577-11	2005	Overall, these results suggested that t-buOOH inactivated TIMP-2, the ambient inhibitor of MMP-2, leading to activation of the ambient proteinase, MMP-2 which subsequently stimulated Ca(2+)-ATPase activity and ATP-dependent Ca2+ uptake, but inhibited Na(+)-dependent Ca2+ uptake, resulting in a marked decrease in Ca2+ uptake in the microsomes.	tert-Butylhydroperoxide	38-45	matrix metallopeptidase 2	Bos taurus	147-152
15082344-0	2004	Ascorbic acid-2-o-phosphate-6-o-palmitate protecting the human umbilical cord vein endothelial cells against hydrogen peroxide and tert-butyl hydroperoxide induced cytotoxicity.	tert-Butylhydroperoxide	131-155	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	9-15
15175014-7	2004	Finally, metformin impaired the t-butyl hydroperoxide-induced cell death, as judged by Trypan Blue exclusion, propidium iodide staining and cytochrome c release.	tert-Butylhydroperoxide	32-53	cytochrome c, somatic	Homo sapiens	140-152
15606011-1	2004	AIM: To explore the possible role of p21, cyclin E and cyclin-dependent kinase 2 (CDK2) in the protection of ginsenoside Rg1 against tert-butylhydroperoxide (t-BHP)-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	133-156	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	121-124
15606011-1	2004	AIM: To explore the possible role of p21, cyclin E and cyclin-dependent kinase 2 (CDK2) in the protection of ginsenoside Rg1 against tert-butylhydroperoxide (t-BHP)-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	158-163	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	121-124
15606011-4	2004	RESULTS: Pretreatment with Rg1 significantly attenuated t-BHP-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	56-61	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	27-30
15606011-5	2004	Simultaneously, compared with cells treated with t-BHP alone, Rg1 pretreatment markedly decreased the level of p21 protein and increased the levels of CDK2 and cyclin E. CONCLUSION: p21, cyclin E and CDK2 may be involved in the process of ginsenoside Rg1 protection against t-BHP-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	49-54	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	62-65
15606011-5	2004	Simultaneously, compared with cells treated with t-BHP alone, Rg1 pretreatment markedly decreased the level of p21 protein and increased the levels of CDK2 and cyclin E. CONCLUSION: p21, cyclin E and CDK2 may be involved in the process of ginsenoside Rg1 protection against t-BHP-induced senescence in WI-38 cells.	tert-Butylhydroperoxide	274-279	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	62-65
15207383-11	2004	The erythrocyte antioxidant enzyme activities, catalase and glutathione peroxidase were decreased in rats treated with tert-butyl hydroperoxide (p <0.05) but were not affected by the other treatments.	tert-Butylhydroperoxide	119-143	catalase	Rattus norvegicus	47-55
15182862-3	2004	Fibroblasts isolated from Sod2(+/-)/Gpx1(-/-) mice were more sensitive (4- to 6-fold) to oxidative stress (t-butyl hydroperoxide or gamma irradiation) than fibroblasts from wild-type mice, and were twice as sensitive as cells from Sod2(+/-) or Gpx1(-/-) mice.	tert-Butylhydroperoxide	107-128	superoxide dismutase 2, mitochondrial	Mus musculus	26-30
15128823-7	2004	Oxidative stress and the transcription factor NF-kappaB were found to be involved in this augmentative effect, because it was mimicked by the oxidant tert-butyl-hydroperoxide, which was blocked both by antioxidants and by inhibition of the NFkappaB pathway using a super-repressor IkappaBM mutant.	tert-Butylhydroperoxide	150-174	nuclear factor kappa B subunit 1	Homo sapiens	46-55
15093734-4	2004	In this study, chemical and physiological hypoxia, which were shown to induce HIF-1alpha stabilization and HIF-1 activation, were shown to inhibit apoptosis induced in HepG2 cells by two different pro-apoptotic conditions, serum deprivation- and t-BHP-induced oxidative stress.	tert-Butylhydroperoxide	246-251	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
15093734-4	2004	In this study, chemical and physiological hypoxia, which were shown to induce HIF-1alpha stabilization and HIF-1 activation, were shown to inhibit apoptosis induced in HepG2 cells by two different pro-apoptotic conditions, serum deprivation- and t-BHP-induced oxidative stress.	tert-Butylhydroperoxide	246-251	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-83
15082344-5	2004	Ascorbic acid-2-o-phosphate-6-o-palmitate could effectively protect the cells against hydrogen peroxide and tert-butyl hydroperoxide induced cytotoxicity, and exhibited no cytotoxicity within the tested concentration range.	tert-Butylhydroperoxide	108-132	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	9-15
14978233-6	2004	Primary hepatocytes from RXRalpha-deficient mice were more sensitive to t-butylhydroperoxide-induced oxidative stress.	tert-Butylhydroperoxide	72-92	retinoid X receptor alpha	Mus musculus	25-33
14729356-7	2004	In acute studies, telomerase activity was increased, p16 initially decreased then normalized, PCNA levels did not change significantly even in the overnight recovery groups, and gadd45 was decreased in some TBHP exposed groups.	tert-Butylhydroperoxide	207-211	growth arrest and DNA damage inducible alpha	Homo sapiens	178-184
15040847-3	2004	Erythrocytes exposed to tBHP also show an increase in mean corpuscular volume and a remarkable formation of methemoglobin (met-Hb) without any appearance of hemichromes that form Heinz bodies.	tert-Butylhydroperoxide	24-28	hemoglobin subunit gamma 2	Homo sapiens	108-121
14732291-5	2004	Cells overexpressing peroxiredoxin 5 were exposed for 1 h to low or acute oxidative stress with exogenously added hydrogen peroxide or tert-butylhydroperoxide.	tert-Butylhydroperoxide	135-158	peroxiredoxin 5	Homo sapiens	21-36
14555484-4	2003	In this study, we show that the C. albicans ssk1 mutant is sensitive to several oxidants, including hydrogen peroxide, t-butyl hydroperoxide, menadione, and potassium superoxide when each is incorporated in yeast extract-peptone-dextrose (YPD) agar medium.	tert-Butylhydroperoxide	119-140	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	44-48
14570699-7	2004	Inhibition of PKC-epsilon translocation using a peptide selective inhibitor, PKC-epsilonV1-2, reduced decreases in basal and uncoupled Qo2 values and increased complex I-linked respiration in TBHP-injured RPTC at 4 h of recovery.	tert-Butylhydroperoxide	192-196	protein kinase C epsilon	Homo sapiens	14-25
14612506-10	2003	The induction of cx43 was observed by mean alpha-particle doses as low as 0.16 cGy, and also in cells exposed to gamma-rays, t-butyl hydroperoxide, and hyperthermia.	tert-Butylhydroperoxide	125-146	gap junction protein alpha 1	Homo sapiens	17-21
14572612-4	2003	Compared to MEFs from Gpx4(+/+) mice, MEFs from Gpx4(+/-) mice were more sensitive to exposure to the oxidizing agent t-butyl hydroperoxide (t-BuOOH), and t-BuOOH exposure induced increased apoptosis in MEFs from Gpx4(+/-) mice.	tert-Butylhydroperoxide	118-139	glutathione peroxidase 4	Mus musculus	48-52
14572612-4	2003	Compared to MEFs from Gpx4(+/+) mice, MEFs from Gpx4(+/-) mice were more sensitive to exposure to the oxidizing agent t-butyl hydroperoxide (t-BuOOH), and t-BuOOH exposure induced increased apoptosis in MEFs from Gpx4(+/-) mice.	tert-Butylhydroperoxide	118-139	glutathione peroxidase 4	Mus musculus	48-52
12851217-6	2003	Moreover, mitochondria that are depleted of matrix adenine nucleotides via the ATP-Mg/Pi carrier show highly increased susceptibility to swelling induced by high Ca2+ concentration, atractyloside, and the prooxidant tert-butylhydroperoxide.	tert-Butylhydroperoxide	216-239	solute carrier family 25 member 25	Rattus norvegicus	79-96
14500501-6	2003	The aox1 mutant strain was also found to be more sensitive to the oxidative stressor tert-butyl hydroperoxide.	tert-Butylhydroperoxide	85-109	aldehyde oxidase 1	Mus musculus	4-8
14732289-3	2004	In this study, we evaluated the cytoprotective effect of MCGA3, which occurs via heme oxygenase-1 (HO-1) induction in bovine vascular endothelial cells exposed to tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	163-186	heme oxygenase 1	Bos taurus	81-97
14732289-3	2004	In this study, we evaluated the cytoprotective effect of MCGA3, which occurs via heme oxygenase-1 (HO-1) induction in bovine vascular endothelial cells exposed to tert-butylhydroperoxide (tBHP).	tert-Butylhydroperoxide	163-186	heme oxygenase 1	Bos taurus	99-103
14732289-4	2004	Cells treated with 1 mM tBHP (6-18 h) generated substantial ROS and concomitantly lost most intracellular lactate dehydrogenase (LDH), which then caused necrotic cell death.	tert-Butylhydroperoxide	24-28	LDH	Bos taurus	106-127
14732289-4	2004	Cells treated with 1 mM tBHP (6-18 h) generated substantial ROS and concomitantly lost most intracellular lactate dehydrogenase (LDH), which then caused necrotic cell death.	tert-Butylhydroperoxide	24-28	LDH	Bos taurus	129-132
14732289-7	2004	We observed the time- and dose-dependent induction of HO-1 mRNA and protein, which was closely associated with decreased intracellular ROS and necrosis against tBHP.	tert-Butylhydroperoxide	160-164	heme oxygenase 1	Bos taurus	54-58
14732289-11	2004	These results suggested that not only ortho-dihydroxyl groups but also aromatic ester and methoxyl ester moieties are necessary for full HO-1 induction and cytoprotection against toxic tBHP-derived ROS.	tert-Butylhydroperoxide	185-189	heme oxygenase 1	Bos taurus	137-141
14732289-13	2004	Consequently, the combined action of HO-1 and ferritin may protect cells from toxic tBHP-mediated necrosis.	tert-Butylhydroperoxide	84-88	heme oxygenase 1	Bos taurus	37-41
12893416-4	2003	Treatment of cells with buthionine sulfoximine, hydrogen peroxide or t-butylhydroperoxide increased the formation of mutant ataxin-1 aggregates, but treatment with the anti-oxidant, N-acetylcysteine (NAC), decreased aggregate formation.	tert-Butylhydroperoxide	69-89	ataxin 1	Homo sapiens	124-132
12665543-3	2003	Total PKC activity decreased 65 and 86% after TBHP and DCVC exposures, respectively, and recovered in TBHP-injured but not in DCVC-injured RPTCs.	tert-Butylhydroperoxide	46-50	proline rich transmembrane protein 2	Homo sapiens	6-9
12665543-3	2003	Total PKC activity decreased 65 and 86% after TBHP and DCVC exposures, respectively, and recovered in TBHP-injured but not in DCVC-injured RPTCs.	tert-Butylhydroperoxide	102-106	proline rich transmembrane protein 2	Homo sapiens	6-9
12665543-5	2003	PKC inhibition decreased the repair of RPTC functions after TBHP injury.	tert-Butylhydroperoxide	60-64	proline rich transmembrane protein 2	Homo sapiens	0-3
12665543-6	2003	PKC activation promoted recovery of mitochondrial function and active Na+ transport in TBHP- and DCVC-injured RPTCs but had no effect on recovery of Na+-dependent glucose uptake.	tert-Butylhydroperoxide	87-91	proline rich transmembrane protein 2	Homo sapiens	0-3
12665543-7	2003	We conclude that in RPTCs, 1) total PKC activity decreases after TBHP and DCVC injury and recovers after TBHP but not after DCVC exposure, 2) recovery of PKC activity precedes the return of physiological functions after oxidant injury, 3) PKC inhibition decreases recovery of physiological functions, and 4) PKC activation promotes recovery of mitochondrial function and active Na+ transport but not Na+-dependent glucose uptake.	tert-Butylhydroperoxide	65-69	proline rich transmembrane protein 2	Homo sapiens	36-39
12665543-7	2003	We conclude that in RPTCs, 1) total PKC activity decreases after TBHP and DCVC injury and recovers after TBHP but not after DCVC exposure, 2) recovery of PKC activity precedes the return of physiological functions after oxidant injury, 3) PKC inhibition decreases recovery of physiological functions, and 4) PKC activation promotes recovery of mitochondrial function and active Na+ transport but not Na+-dependent glucose uptake.	tert-Butylhydroperoxide	105-109	proline rich transmembrane protein 2	Homo sapiens	36-39
12861054-5	2003	Prdx3 overexpression also protected the cells against apoptosis caused by H(2)O(2), t-butylhydroperoxide, and the anticancer drug imexon, but not by dexamethasone.	tert-Butylhydroperoxide	84-104	peroxiredoxin 3	Mus musculus	0-5
12808106-7	2003	Fetal livers from mutant embryos exhibited increased oxidative stress and impaired expression of antioxidant genes, and primary cultures of nrf1(-/-) fetal hepatocytes were sensitive to tert-butyl hydroperoxide-induced cell death, suggesting that impaired antioxidant defense may be responsible for the apoptosis observed in the livers of chimeric mice.	tert-Butylhydroperoxide	186-210	nuclear respiratory factor 1	Mus musculus	140-144
12663656-2	2003	In particular, HMP possesses a high catalytic activity and a low Km toward cumyl, linoleic acid, and tert-butyl hydroperoxides, whereas it is a less efficient hydrogen peroxide scavenger.	tert-Butylhydroperoxide	101-126	inner membrane mitochondrial protein	Homo sapiens	15-18
12745250-6	2003	In agreement with this hypothesis was the finding that the physiologic reductant N-acetylcysteine decreased Grx-1 expression whereas tert-butyl hydroperoxide increased Grx-1 expression.	tert-Butylhydroperoxide	133-157	glutaredoxin	Homo sapiens	168-173
12684511-5	2003	We now show that Grx2 is also a general hydroperoxidase, and kinetic data indicate that both enzymes have a similar pattern of activity, which is highest with hydrogen peroxide, followed by cumene hydroperoxide and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	215-239	dithiol glutaredoxin GRX2	Saccharomyces cerevisiae S288C	17-21
12704795-2	2003	Here, we investigate the mechanism of oxidant-induced cell death and to investigate the role of Bcl-2 in the tert-butyl hydroperoxide (t-BuOOH)-induced oxidant injury in Rat-1 fibroblasts and their bcl-2 transfected counterparts, b5 cells.	tert-Butylhydroperoxide	109-133	BCL2, apoptosis regulator	Rattus norvegicus	96-101
12753922-4	2003	tert-Butylhydroperoxide caused an increase in the total amount of nuclear Trx1, but this was accompanied by a 60 mV oxidation.	tert-Butylhydroperoxide	0-23	thioredoxin	Homo sapiens	74-78
12704795-2	2003	Here, we investigate the mechanism of oxidant-induced cell death and to investigate the role of Bcl-2 in the tert-butyl hydroperoxide (t-BuOOH)-induced oxidant injury in Rat-1 fibroblasts and their bcl-2 transfected counterparts, b5 cells.	tert-Butylhydroperoxide	109-133	BCL2, apoptosis regulator	Rattus norvegicus	198-203
12784865-2	2003	An isomer of CLA, 9(Z),11 (E)-octadecadienoic acid (1), believed to have anticarcinogenic activity, was used as a substrate for peroxygenase in an aqueous medium using t-butyl hydroperoxide as the oxidant.	tert-Butylhydroperoxide	168-189	selectin P ligand	Homo sapiens	13-16
12551919-5	2003	Accordingly, the stable overexpression of Mn-SOD attenuated TBH-induced mitochondrial ROS generation and cell apoptosis.	tert-Butylhydroperoxide	60-63	superoxide dismutase 2	Rattus norvegicus	42-48
12551919-8	2003	Collectively, our results support a role for mitochondrial ROS in TBH-induced PC-12 apoptosis that is attenuated by Mn-SOD overexpression and is independent of cellular GSH levels per se.	tert-Butylhydroperoxide	66-69	superoxide dismutase 2	Rattus norvegicus	116-122
12566075-6	2003	Interestingly, cell lines derived from Gpx4(+/-) mice are markedly sensitive to inducers of oxidative stress, including gamma-irradiation, paraquat, tert-butylhydroperoxide, and hydrogen peroxide, as compared to cell lines derived from wild-type control littermates.	tert-Butylhydroperoxide	149-172	glutathione peroxidase 4	Mus musculus	39-43
12626113-7	2003	However, the poplar glutaredoxin may be involved in the response to oxidative stress as its overexpression in Escherichia coli resulted in a higher resistance toward hydrogen peroxide, menadione, and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	200-224	glutaredoxin	Homo sapiens	20-32
12479875-2	2003	Cyclin-dependent kinase inhibitor (CdKI) p21(Waf-1) is overexpressed in H2O2- and tert-butylhydroperoxide-induced premature senescence, likely explaining in part the hypophosphorylation of the retinoblastoma protein.	tert-Butylhydroperoxide	82-105	cyclin dependent kinase inhibitor 1A	Homo sapiens	41-44
12479875-2	2003	Cyclin-dependent kinase inhibitor (CdKI) p21(Waf-1) is overexpressed in H2O2- and tert-butylhydroperoxide-induced premature senescence, likely explaining in part the hypophosphorylation of the retinoblastoma protein.	tert-Butylhydroperoxide	82-105	cyclin dependent kinase inhibitor 1A	Homo sapiens	45-50
14631140-7	2003	Hyperosmotic shock (exposure to 700 mOsm) and oxidative stress (exposure to 0.1 mM tert-butyl-hydroperoxide) significantly decreased the cell volume and increased the number of annexin binding sites of erythrocytes from both, taut-/- and taut+/+ mice.	tert-Butylhydroperoxide	83-107	annexin A11, opposite strand	Mus musculus	177-184
12723751-6	2003	In our present results, M-CSF could alleviate the Ox-LDL- or tert-butyl hydroperoxide (tbOOH)-induced injury to mouse peritoneal macrophages, and PSK exhibited some similar effects.	tert-Butylhydroperoxide	61-85	colony stimulating factor 1 (macrophage)	Mus musculus	24-29
12723751-6	2003	In our present results, M-CSF could alleviate the Ox-LDL- or tert-butyl hydroperoxide (tbOOH)-induced injury to mouse peritoneal macrophages, and PSK exhibited some similar effects.	tert-Butylhydroperoxide	87-92	colony stimulating factor 1 (macrophage)	Mus musculus	24-29
14631140-7	2003	Hyperosmotic shock (exposure to 700 mOsm) and oxidative stress (exposure to 0.1 mM tert-butyl-hydroperoxide) significantly decreased the cell volume and increased the number of annexin binding sites of erythrocytes from both, taut-/- and taut+/+ mice.	tert-Butylhydroperoxide	83-107	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	Mus musculus	226-233
12494333-10	2002	DTD:DT-diaphorase GSH:glutathione LDH:lactate dehydrogenase MDA:malondialdehyde MTT:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide TBHP: tert-butyl hydroperoxide	tert-Butylhydroperoxide	145-149	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	4-17
12494333-10	2002	DTD:DT-diaphorase GSH:glutathione LDH:lactate dehydrogenase MDA:malondialdehyde MTT:3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide TBHP: tert-butyl hydroperoxide	tert-Butylhydroperoxide	151-175	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	4-17
12407167-2	2002	METHODS: Primary cultured hRPE cells were incubated with various concentrations of oltipraz followed by treatment with the chemical oxidant tert-butylhydroperoxide (tBH).	tert-Butylhydroperoxide	140-163	ribulose-5-phosphate-3-epimerase	Homo sapiens	26-30
12423650-7	2002	In the TE model, radical scavengers, namely thiourea, urea and mannitol, as well as antioxidants such as glutathione and catalase inhibited the t-bHP-induced lipid peroxidation response to varying degree.	tert-Butylhydroperoxide	144-149	catalase	Rattus norvegicus	121-129
12423650-9	2002	Further co-incubation of TE either with mercaptosuccinate (a potent glutathione peroxidase inhibitor) or 3-aminotriazole (an irreversible catalase inhibitor) resulted in a marked increase in t-bHP-induced lipid peroxidation, clearly suggesting the importance of both of these enzymic antioxidants in rat testis in vitro.	tert-Butylhydroperoxide	191-196	catalase	Rattus norvegicus	138-146
12407167-6	2002	RESULTS: Treatment of hRPE cells with oltipraz inhibited tBH-induced cell death in a concentration-dependent manner with significant inhibition at 50 micro M. Olitpraz (50 micro M) increased GSH levels in hRPE cells by approximately 18% and in hRPE mitochondrial fractions by approximately 50% after 24 hours of exposure.	tert-Butylhydroperoxide	57-60	ribulose-5-phosphate-3-epimerase	Homo sapiens	22-26
12407167-8	2002	CONCLUSIONS: Oltipraz protects hRPE cells against tBH induced injury.	tert-Butylhydroperoxide	50-53	ribulose-5-phosphate-3-epimerase	Homo sapiens	31-35
12193653-4	2002	Overexpressing cells (C17 or C48) degraded H(2)O(2) and t-butylhydroperoxide more rapidly and showed decreased sensitivity to oxidant stress as measured by (51)Cr release.	tert-Butylhydroperoxide	56-76	cytokine like 1	Homo sapiens	22-25
12709297-0	2002	Nicotinamide protects HCN2 cells from the free radical generating toxin, tertiary butylhydroperoxide (t-BuOOH).	tert-Butylhydroperoxide	73-100	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Homo sapiens	22-26
12193653-4	2002	Overexpressing cells (C17 or C48) degraded H(2)O(2) and t-butylhydroperoxide more rapidly and showed decreased sensitivity to oxidant stress as measured by (51)Cr release.	tert-Butylhydroperoxide	56-76	CDK5 regulatory subunit associated protein 2	Homo sapiens	29-32
12181751-8	2002	Collectively, these results show that TBH-induced GSSG elevation is associated with the disruption of mitochondrial integrity, activation of caspase-3 and cell apoptosis.	tert-Butylhydroperoxide	38-41	caspase 3	Rattus norvegicus	141-150
11875065-3	2002	Elevating the gene dosage of GRX1 or GRX2 increases resistance to hydroperoxides including hydrogen peroxide, tert-butyl hydroperoxide and cumene hydroperoxide.	tert-Butylhydroperoxide	110-134	dithiol glutaredoxin GRX1	Saccharomyces cerevisiae S288C	29-33
12126254-9	2002	RESULTS: TNF-alpha diminished the concentrations of malondialdehyde and activities of lactate dehydrogenase in hepatocytes exposed to tert-butyl hydroperoxide.	tert-Butylhydroperoxide	134-158	tumor necrosis factor	Rattus norvegicus	9-18
11875065-3	2002	Elevating the gene dosage of GRX1 or GRX2 increases resistance to hydroperoxides including hydrogen peroxide, tert-butyl hydroperoxide and cumene hydroperoxide.	tert-Butylhydroperoxide	110-134	dithiol glutaredoxin GRX2	Saccharomyces cerevisiae S288C	37-41
12033392-2	2002	METHODS: DHP was oxidized by hydrogen peroxide, t-butylhydroperoxide, or peroxyl radicals derived from the thermal decomposition of 2,2"-azobis(2-amidinopropane) dihydrochloride (AAPH) in 40% (v/v) organic cosolvent and 5 mM buffer at or near 40 degrees C. Interactions between DHP and ]propane sulfonic acid and imidazole) and DH- were assessed by 1H-NMR spectroscopy.	tert-Butylhydroperoxide	48-68	dihydropyrimidinase	Homo sapiens	9-12
11782473-7	2002	In primary hepatocytes, an exogenous oxidant, tert-butyl-hydroperoxide (TBHP), which increased ROS production, up-regulated UCP2 mRNA, whereas WY14,643 treatment did not produce detectable ROS under the condition that fibrate markedly up-regulated UCP2.	tert-Butylhydroperoxide	46-70	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	124-128
11782473-7	2002	In primary hepatocytes, an exogenous oxidant, tert-butyl-hydroperoxide (TBHP), which increased ROS production, up-regulated UCP2 mRNA, whereas WY14,643 treatment did not produce detectable ROS under the condition that fibrate markedly up-regulated UCP2.	tert-Butylhydroperoxide	46-70	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	248-252
11782473-7	2002	In primary hepatocytes, an exogenous oxidant, tert-butyl-hydroperoxide (TBHP), which increased ROS production, up-regulated UCP2 mRNA, whereas WY14,643 treatment did not produce detectable ROS under the condition that fibrate markedly up-regulated UCP2.	tert-Butylhydroperoxide	72-76	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	124-128
11782473-7	2002	In primary hepatocytes, an exogenous oxidant, tert-butyl-hydroperoxide (TBHP), which increased ROS production, up-regulated UCP2 mRNA, whereas WY14,643 treatment did not produce detectable ROS under the condition that fibrate markedly up-regulated UCP2.	tert-Butylhydroperoxide	72-76	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	248-252
12147583-12	2002	The nondividing hRPE cells appeared more susceptible to tBH-induced apoptosis.	tert-Butylhydroperoxide	56-59	ribulose-5-phosphate-3-epimerase	Homo sapiens	16-20
12147583-13	2002	Similar to proliferating hRPE cells, the apoptosis induced by tBH was preceded by induction of FasL, and antioxidants inhibited both FasL increase and apoptosis.	tert-Butylhydroperoxide	62-65	Fas ligand	Homo sapiens	95-99
12147583-17	2002	The increased sensitivity to tBH-induced apoptosis in these cells was associated with intracellular oxidation and upregulation of FasL.	tert-Butylhydroperoxide	29-32	Fas ligand	Homo sapiens	130-134
12236590-1	2002	Treatment of bovine pulmonary artery smooth muscle plasma membrane suspension with the oxidant tert-butylhydroperoxide (t-buOOH) increases Ca2+ATPase activity.	tert-Butylhydroperoxide	95-118	carbonic anhydrase 2	Bos taurus	139-149
11827753-7	2002	Finally, mTPx I also induced by t-butyl hydroperoxide in a Hap1p-independent manner.	tert-Butylhydroperoxide	32-53	peroxiredoxin 2	Mus musculus	9-13
11904147-2	2002	We report for the first time that procaspase 3 present in the anucleated mature human erythrocyte is activated under oxidative stress induced by t-butylhydroperoxide leading to impairment of the aminophospholipid translocase, PS externalization and increased erythrophagocytosis.	tert-Butylhydroperoxide	145-165	caspase 3	Homo sapiens	34-46
11827753-7	2002	Finally, mTPx I also induced by t-butyl hydroperoxide in a Hap1p-independent manner.	tert-Butylhydroperoxide	32-53	Hap1p	Saccharomyces cerevisiae S288C	59-64
11853890-7	2002	Western blot analysis of cytochrome c shows that its level increases in the cytosol while that of Bax decreases in this fraction as a result of t-BHP treatment.	tert-Butylhydroperoxide	144-149	BCL2 associated X, apoptosis regulator	Rattus norvegicus	98-101
11883705-8	2002	Hyperpnea with 95% O2-5% CO2, but not with 95% air-5% CO2, gas mixture induced significant increase in t-butyl hydroperoxide-initiated CL counts, which were inhibited by DMTU, catalase, or SOD in vitro.	tert-Butylhydroperoxide	103-124	catalase	Cavia porcellus	176-184
11883705-8	2002	Hyperpnea with 95% O2-5% CO2, but not with 95% air-5% CO2, gas mixture induced significant increase in t-butyl hydroperoxide-initiated CL counts, which were inhibited by DMTU, catalase, or SOD in vitro.	tert-Butylhydroperoxide	103-124	superoxide dismutase [Mn], mitochondrial	Cavia porcellus	189-192
11812934-8	2002	The results demonstrated that (1) the apoptotic effect of 4 out of 5 compounds could be detected in low concentrations of the drugs long before cell necrosis (tertiary-butyl-hydroperoxide-induced apoptosis was only detected at concentrations causing concomitant necrosis) and (2) among the markers evaluated, caspase 3 activation and nucleus and DNA analysis by flow cytometry were used to fulfil the compromise between reliability, sensitivity, and ease of performance, which are critical issues when screening for an apoptotic effect of newly developed drugs.	tert-Butylhydroperoxide	159-187	caspase 3	Homo sapiens	309-318
11853890-8	2002	Moreover, there is a loss of Bcl-2 from mitochondria while, in contrast, Bax accumulates in this organelle following t-BHP treatment.	tert-Butylhydroperoxide	117-122	BCL2 associated X, apoptosis regulator	Rattus norvegicus	73-76
11892985-0	2002	Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxide.	tert-Butylhydroperoxide	134-157	clusterin	Homo sapiens	18-34
11892985-5	2002	The overexpression of apo J resulted in an increased cell survival after t-BHP and EtOH stresses at cytotoxic concentrations.	tert-Butylhydroperoxide	73-78	clusterin	Homo sapiens	22-27
11112584-5	2000	The O-O bond dissociation energies computed at G2 and G2(MP2) levels for bis(tert-butyl) peroxide and tert-butyl hydroperoxide are 45.2 and 48.3 kcal/mol, respectively.	tert-Butylhydroperoxide	102-126	tryptase pseudogene 1	Homo sapiens	57-60
11446766-12	2001	Exposure to the chemical oxidant tert-butylhydroperoxide (TBH) up-regulated SVCT2 gene expression in HLE-B3 cells.	tert-Butylhydroperoxide	33-56	solute carrier family 23 member 2	Homo sapiens	76-81
11446766-12	2001	Exposure to the chemical oxidant tert-butylhydroperoxide (TBH) up-regulated SVCT2 gene expression in HLE-B3 cells.	tert-Butylhydroperoxide	58-61	solute carrier family 23 member 2	Homo sapiens	76-81
11710803-1	2001	In aqueous solution, ascorbate potently prevents bleaching of cytochrome c on exposure to excess H2O2 or t-butyl hydroperoxide.	tert-Butylhydroperoxide	105-126	cytochrome c, somatic	Homo sapiens	62-74
11523781-6	2001	Mutagen sensitivity and enhanced mutagenesis in the rad1 ntg1 ntg2 triple mutant, relative to the other strains tested, were also observed upon exposure to oxidizing agents such as tertbutylhydroperoxide and menadione.	tert-Butylhydroperoxide	181-203	ssDNA endodeoxyribonuclease RAD1	Saccharomyces cerevisiae S288C	52-56
11523781-6	2001	Mutagen sensitivity and enhanced mutagenesis in the rad1 ntg1 ntg2 triple mutant, relative to the other strains tested, were also observed upon exposure to oxidizing agents such as tertbutylhydroperoxide and menadione.	tert-Butylhydroperoxide	181-203	bifunctional N-glycosylase/AP lyase NTG1	Saccharomyces cerevisiae S288C	57-61
11523781-6	2001	Mutagen sensitivity and enhanced mutagenesis in the rad1 ntg1 ntg2 triple mutant, relative to the other strains tested, were also observed upon exposure to oxidizing agents such as tertbutylhydroperoxide and menadione.	tert-Butylhydroperoxide	181-203	bifunctional N-glycosylase/AP lyase NTG2	Saccharomyces cerevisiae S288C	62-66
11056165-8	2001	We show that the transcription of FLR1 is induced upon cell treatment with the oxidizing agents diamide, diethylmaleate, hydrogen peroxide, and tert-butyl hydroperoxide, the antimitotic drug benomyl, and the alkylating agent methylmethane sulfonate and that this induction is mediated by Yap1p through the three YREs.	tert-Butylhydroperoxide	144-168	Flr1p	Saccharomyces cerevisiae S288C	34-38
11056165-8	2001	We show that the transcription of FLR1 is induced upon cell treatment with the oxidizing agents diamide, diethylmaleate, hydrogen peroxide, and tert-butyl hydroperoxide, the antimitotic drug benomyl, and the alkylating agent methylmethane sulfonate and that this induction is mediated by Yap1p through the three YREs.	tert-Butylhydroperoxide	144-168	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	288-293
11201240-5	2001	Enzymatic removal of sialyl residues and the degradation of poly-N-acetyllactosaminyl sugar chains by pretreatment of PMNs with neuraminidase or endo-beta-galactosidase, respectively, lost their increasing ability for macrophage adhesion after oxidation with diamide, superoxide or t-butylhydroperoxide.	tert-Butylhydroperoxide	282-302	galactosidase, beta 1	Mus musculus	150-168
11787996-1	2001	Previously, we found that macrophage colony-stimulating factor (M-CSF) could reduce tert-butyl hydroperoxide (tbOOH)-induced oxidative injury in monocytes/macrophages.	tert-Butylhydroperoxide	84-108	colony stimulating factor 1 (macrophage)	Mus musculus	26-62
11787996-1	2001	Previously, we found that macrophage colony-stimulating factor (M-CSF) could reduce tert-butyl hydroperoxide (tbOOH)-induced oxidative injury in monocytes/macrophages.	tert-Butylhydroperoxide	84-108	colony stimulating factor 1 (macrophage)	Mus musculus	64-69
11787996-1	2001	Previously, we found that macrophage colony-stimulating factor (M-CSF) could reduce tert-butyl hydroperoxide (tbOOH)-induced oxidative injury in monocytes/macrophages.	tert-Butylhydroperoxide	110-115	colony stimulating factor 1 (macrophage)	Mus musculus	26-62
11787996-1	2001	Previously, we found that macrophage colony-stimulating factor (M-CSF) could reduce tert-butyl hydroperoxide (tbOOH)-induced oxidative injury in monocytes/macrophages.	tert-Butylhydroperoxide	110-115	colony stimulating factor 1 (macrophage)	Mus musculus	64-69
12213969-1	2001	We discovered the acute inhibition of myocardial phospholipase A2 activity by micromolar concentrations of tert-butyl hydroperoxide and hydrogen peroxide.	tert-Butylhydroperoxide	107-131	phospholipase A2 group IB	Rattus norvegicus	49-65
12213969-6	2001	This conclusion was further validated by the experiments in which pretreatment with the calcium-independent phospholipase A2 inhibitor bromoenol lactone exacerbated cardiotoxicity of tert-butyl hydroperoxide in myocyte cultures.	tert-Butylhydroperoxide	183-207	phospholipase A2 group IB	Rattus norvegicus	108-124
11597127-0	2001	TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation.	tert-Butylhydroperoxide	105-128	tumor necrosis factor	Homo sapiens	0-8
11597127-1	2001	Treatment of U937 cells with nontoxic concentrations of TNFalpha increased the DNA strand scission induced by a short-chain lipid hydroperoxide analogue, tert-butylhydroperoxide.	tert-Butylhydroperoxide	154-177	tumor necrosis factor	Homo sapiens	56-64
11597127-4	2001	Three lines of evidence support this inference: (a) a synthetic cell-permeable ceramide analogue reproduced all the effects of TNFalpha, (b) TNFalpha promoted the formation of ceramide via a mechanism sensitive to inhibition of sphingomyelinases by tricyclodecan-9-yl-xanthogenate and imipramine, and (c) the TNFalpha-mediated enhancement of the tert-butylhydroperoxide-induced DNA-damaging response was prevented under conditions in which ceramide formation was inhibited.	tert-Butylhydroperoxide	346-369	tumor necrosis factor	Homo sapiens	141-149
11597127-4	2001	Three lines of evidence support this inference: (a) a synthetic cell-permeable ceramide analogue reproduced all the effects of TNFalpha, (b) TNFalpha promoted the formation of ceramide via a mechanism sensitive to inhibition of sphingomyelinases by tricyclodecan-9-yl-xanthogenate and imipramine, and (c) the TNFalpha-mediated enhancement of the tert-butylhydroperoxide-induced DNA-damaging response was prevented under conditions in which ceramide formation was inhibited.	tert-Butylhydroperoxide	346-369	tumor necrosis factor	Homo sapiens	141-149
11606183-0	2001	Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity.	tert-Butylhydroperoxide	21-44	poly (ADP-ribose) polymerase 1	Rattus norvegicus	134-161
11606183-7	2001	Collectively, our data suggest that tert-butylhydroperoxide-induced peroxynitrite-independent DNA strand scission is far less effective than the DNA cleavage generated by endogenous peroxynitrite in stimulating the activity of poly(ADP-ribose) polymerase.	tert-Butylhydroperoxide	36-59	poly (ADP-ribose) polymerase 1	Rattus norvegicus	227-254
11581219-6	2001	Differentiated ARPE-19 cells treated with tBH or H2O2 resulted in upregulation of the HO-1 and FGFR1 transcripts.	tert-Butylhydroperoxide	42-45	heme oxygenase 1	Homo sapiens	86-90
11581219-6	2001	Differentiated ARPE-19 cells treated with tBH or H2O2 resulted in upregulation of the HO-1 and FGFR1 transcripts.	tert-Butylhydroperoxide	42-45	fibroblast growth factor receptor 1	Homo sapiens	95-100
11581219-7	2001	The expression of RPE-differentiated specific genes, including FGFR2, CRALBP, and RPE65 mRNAs, was downregulated with tBH or H2O2 treatment.	tert-Butylhydroperoxide	118-121	ribulose-5-phosphate-3-epimerase	Homo sapiens	18-21
11581219-7	2001	The expression of RPE-differentiated specific genes, including FGFR2, CRALBP, and RPE65 mRNAs, was downregulated with tBH or H2O2 treatment.	tert-Butylhydroperoxide	118-121	fibroblast growth factor receptor 2	Homo sapiens	63-68
11581219-7	2001	The expression of RPE-differentiated specific genes, including FGFR2, CRALBP, and RPE65 mRNAs, was downregulated with tBH or H2O2 treatment.	tert-Butylhydroperoxide	118-121	retinaldehyde binding protein 1	Homo sapiens	70-76
11581219-7	2001	The expression of RPE-differentiated specific genes, including FGFR2, CRALBP, and RPE65 mRNAs, was downregulated with tBH or H2O2 treatment.	tert-Butylhydroperoxide	118-121	retinoid isomerohydrolase RPE65	Homo sapiens	82-87
11551515-11	2001	We conclude that TBHP stimulates the release of [14C]-AA from membrane phospholipids through a PLA(2)-mediated mechanism.	tert-Butylhydroperoxide	17-21	phospholipase A2 group IB	Rattus norvegicus	95-101
11551515-13	2001	Results suggest that specific ROS generated in iron-dependent reactions, different from lipid peroxyl radicals, are involved in PLA(2) activation, this process being important in TBHP-induced hepatocyte injury.	tert-Butylhydroperoxide	179-183	phospholipase A2 group IB	Rattus norvegicus	128-134
11514315-3	2001	Mitochondrial function was altered in the Sod2(-/+) mice, as shown by decreased respiration by complex I and an increase in the sensitivity of the permeability transition to induction by calcium and t-butylhydroperoxide.	tert-Butylhydroperoxide	199-219	superoxide dismutase 2, mitochondrial	Mus musculus	42-46
11803485-7	2001	At nontoxic concentrations of tBH and H(2)O(2), a dose dependent increase in FGF-2 expression was seen as a function of culture density.	tert-Butylhydroperoxide	30-33	fibroblast growth factor 2	Homo sapiens	77-82
11803485-8	2001	FGF-2 mRNA expression was induced after tBH treatment in subconfluent, but not confluent cells.	tert-Butylhydroperoxide	40-43	fibroblast growth factor 2	Homo sapiens	0-5
11178967-3	2001	The AML-2/DX100 also showed various levels of resistance to daunorubicin and vincristine but was paradoxically sensitive to hydrogen peroxide (5-fold), t-butyl hydroperoxide (3-fold), and paraquat (2-fold) when compared to the drug-sensitive parental AML-2 cells (AML-2/WT).	tert-Butylhydroperoxide	152-173	RUNX family transcription factor 3	Homo sapiens	4-9
11245440-5	2001	In this study, we show that both human epithelial and mouse embryo fibroblast cell lines lacking the MLH1 protein are more resistant to two inducers of oxidative stress, hydrogen peroxide and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	192-216	mutL homolog 1	Mus musculus	101-105
11322648-4	2001	Pretreatment with cyclosporin A (0.5 microM) reduced t-BHP-induced cytosolic Ca2+ increase and ALT (alanine-aminotransferase) leakage, but had no protective effect on t-BHP-induced changes of mitochondrial membrane potential.	tert-Butylhydroperoxide	53-58	glutamic--pyruvic transaminase	Homo sapiens	95-98
11322648-5	2001	Our data thus suggest that the mechanism of cytoprotection of CsA on the cytosolic Ca2+ changes and ALT leakage induced by t-BHP, does not directly correlate with protection of t-BHP-induced changes of mitochondrial membrane potential.	tert-Butylhydroperoxide	123-128	glutamic--pyruvic transaminase	Homo sapiens	100-103
11068048-1	2000	The reaction of native myeloperoxidase (MPO) and its redox intermediate compound I with hydrogen peroxide, ethyl hydroperoxide, peroxyacetic acid, t-butyl hydroperoxide, 3-chloroperoxybenzoic acid and cumene hydroperoxide was studied by multi-mixing stopped-flow techniques.	tert-Butylhydroperoxide	147-168	myeloperoxidase	Homo sapiens	23-38
11068048-1	2000	The reaction of native myeloperoxidase (MPO) and its redox intermediate compound I with hydrogen peroxide, ethyl hydroperoxide, peroxyacetic acid, t-butyl hydroperoxide, 3-chloroperoxybenzoic acid and cumene hydroperoxide was studied by multi-mixing stopped-flow techniques.	tert-Butylhydroperoxide	147-168	myeloperoxidase	Homo sapiens	40-43
11018516-2	2000	A cDNA named CEO1 increased the tolerance to oxidative damage caused by tert-butylhydroperoxide of both the Yap1(-) mutant and the wild-type yeast.	tert-Butylhydroperoxide	72-95	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	13-17
11032771-5	2000	Furthermore, while diethyl maleate (DEM) exposure to deplete cellular glutathione did not induce expression of GLCL-H, exposure to tertiary-butyl hydroperoxide (tBH), an oxidizing agent, resulted in significant upregulation of GLCL-H expression in two-cell embryos.	tert-Butylhydroperoxide	131-159	glutamate-cysteine ligase, catalytic subunit	Mus musculus	227-233
11032771-5	2000	Furthermore, while diethyl maleate (DEM) exposure to deplete cellular glutathione did not induce expression of GLCL-H, exposure to tertiary-butyl hydroperoxide (tBH), an oxidizing agent, resulted in significant upregulation of GLCL-H expression in two-cell embryos.	tert-Butylhydroperoxide	161-164	glutamate-cysteine ligase, catalytic subunit	Mus musculus	227-233
11065171-0	2000	T-butyl hydrogen peroxide increases the activities of the Maxi-K channels of rat brain.	tert-Butylhydroperoxide	0-25	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	58-64
11065171-1	2000	In this study, we investigated the effects of tertiary-butyl hydrogen peroxide (tBHP) on the large-conductance Ca2+-activated K+ (Maxi-K) channel of rat brain using lipid bilayer.	tert-Butylhydroperoxide	80-84	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	130-136
11065171-2	2000	When tBHP was applied to the cytosolic side, the open probability (Po) of both fast- and slow-gating Maxi-K channels increased within 1 min in dose-dependent manner.	tert-Butylhydroperoxide	5-9	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	101-107
11097384-2	2000	A short-chain analog of lipid hydroperoxide, t-butyl hydroperoxide (t-BHP), can be metabolized to free radical intermediates by cytochrome P-450 in hepatocytes, which in turn can initiate lipid peroxidation, affect cell integrity and result in cell injury.	tert-Butylhydroperoxide	45-66	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	128-144
11097384-2	2000	A short-chain analog of lipid hydroperoxide, t-butyl hydroperoxide (t-BHP), can be metabolized to free radical intermediates by cytochrome P-450 in hepatocytes, which in turn can initiate lipid peroxidation, affect cell integrity and result in cell injury.	tert-Butylhydroperoxide	68-73	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	128-144
11200081-7	2000	The increased formation of DNA lesions resulting from exposure to tert-butylhydroperoxide associated with the Ca2+-mobilizing agents or the respiratory substrate was mediated by arachidonic acid generated by Ca2+-dependent activation of phospholipase A2.	tert-Butylhydroperoxide	66-89	phospholipase A2 group IB	Homo sapiens	237-253
11200081-8	2000	Melittin, a potent phospholipase A2 activator, and reagent arachidonic acid mimicked the effects of caffeine, ATP or pyruvate on the tert-butylhydroperoxide-induced DNA single strand breakage.	tert-Butylhydroperoxide	133-156	phospholipase A2 group IB	Homo sapiens	19-35
11018516-2	2000	A cDNA named CEO1 increased the tolerance to oxidative damage caused by tert-butylhydroperoxide of both the Yap1(-) mutant and the wild-type yeast.	tert-Butylhydroperoxide	72-95	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	108-112
10937881-0	2000	Retrieval of the mrp2 gene encoded conjugate export pump from the canalicular membrane contributes to cholestasis induced by tert-butyl hydroperoxide and chloro-dinitrobenzene.	tert-Butylhydroperoxide	125-149	ATP binding cassette subfamily C member 2	Rattus norvegicus	17-21
10968412-3	2000	Cell death caused by treatment with prooxidant tert-butylhydroperoxide (TBH), H2O2, or CdCl2 was considerably suppressed in PLC-beta1 overexpressed NIH/beta1-14 cells in comparison to control NIH/neo cells.	tert-Butylhydroperoxide	47-70	phospholipase C, beta 1	Mus musculus	124-133
10968412-3	2000	Cell death caused by treatment with prooxidant tert-butylhydroperoxide (TBH), H2O2, or CdCl2 was considerably suppressed in PLC-beta1 overexpressed NIH/beta1-14 cells in comparison to control NIH/neo cells.	tert-Butylhydroperoxide	72-75	phospholipase C, beta 1	Mus musculus	124-133
10968412-5	2000	In addition, while accumulation of c-fos mRNA was observed within 30 min of TBH treatment in vector transfected NIH/neo cells, TBH-induced c-fos mRNA generation was completely suppressed in NIH/beta1-14 cells, while that of c-jun and GAPDH was not affected.	tert-Butylhydroperoxide	76-79	FBJ osteosarcoma oncogene	Mus musculus	35-40
10968412-5	2000	In addition, while accumulation of c-fos mRNA was observed within 30 min of TBH treatment in vector transfected NIH/neo cells, TBH-induced c-fos mRNA generation was completely suppressed in NIH/beta1-14 cells, while that of c-jun and GAPDH was not affected.	tert-Butylhydroperoxide	127-130	FBJ osteosarcoma oncogene	Mus musculus	139-144
10968412-5	2000	In addition, while accumulation of c-fos mRNA was observed within 30 min of TBH treatment in vector transfected NIH/neo cells, TBH-induced c-fos mRNA generation was completely suppressed in NIH/beta1-14 cells, while that of c-jun and GAPDH was not affected.	tert-Butylhydroperoxide	127-130	jun proto-oncogene	Mus musculus	224-229
10968412-5	2000	In addition, while accumulation of c-fos mRNA was observed within 30 min of TBH treatment in vector transfected NIH/neo cells, TBH-induced c-fos mRNA generation was completely suppressed in NIH/beta1-14 cells, while that of c-jun and GAPDH was not affected.	tert-Butylhydroperoxide	127-130	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	234-239
10993480-10	2000	These results suggest that tBOOH may increase intracellular Ca2+ through the activation of reverse mode of Na+/Ca2+ exchanger.	tert-Butylhydroperoxide	27-32	solute carrier family 8 member A1	Homo sapiens	107-125
10993480-12	2000	These results indicate that ROI generated by tBOOH may increase intracellular Ca2+ concentration by direct activation of the reverse mode of Na+/Ca2+ exchanger, rather than indirect elevation of intracellular Na+ levels.	tert-Butylhydroperoxide	45-50	solute carrier family 8 member A1	Homo sapiens	141-159
10956421-6	2000	Treatment of the cells with the general caspase inhibitor Boc-Asp(OMe)-Fluoromethylketone (BAF) completely inhibited caspase-3 activation in response to tBHP, and delayed, but did not prevent cell death.	tert-Butylhydroperoxide	153-157	caspase 3	Homo sapiens	117-126
10937881-2	2000	In this study we have characterized the short-term effects of tert-butyl hydroperoxide (t-BOOH)- and 1-chloro-2,4-dinitrobenzene (CDNB) on the mrp2 gene encoded canalicular export pump (Mrp2).	tert-Butylhydroperoxide	62-86	ATP binding cassette subfamily C member 2	Rattus norvegicus	143-147
10937881-2	2000	In this study we have characterized the short-term effects of tert-butyl hydroperoxide (t-BOOH)- and 1-chloro-2,4-dinitrobenzene (CDNB) on the mrp2 gene encoded canalicular export pump (Mrp2).	tert-Butylhydroperoxide	62-86	ATP binding cassette subfamily C member 2	Rattus norvegicus	186-190
10780956-1	2000	A short term exposure of PC12 cells to a concentration of tert-butylhydroperoxide (tB-OOH) causing peroxynitrite-dependent DNA damage and cytotoxiticity promoted a release of arachidonic acid (AA) that was sensitive to phospholipase A(2) (PLA(2)) inhibitors and insensitive to phospholipase C or diacylglycerol lipase inhibitors.	tert-Butylhydroperoxide	58-81	phospholipase A2 group IB	Rattus norvegicus	219-237
10780956-1	2000	A short term exposure of PC12 cells to a concentration of tert-butylhydroperoxide (tB-OOH) causing peroxynitrite-dependent DNA damage and cytotoxiticity promoted a release of arachidonic acid (AA) that was sensitive to phospholipase A(2) (PLA(2)) inhibitors and insensitive to phospholipase C or diacylglycerol lipase inhibitors.	tert-Butylhydroperoxide	58-81	phospholipase A2 group IB	Rattus norvegicus	239-245
10711676-10	2000	tBH treatment of hRPE cells resulted in increased expression of FasL and Fas.	tert-Butylhydroperoxide	0-3	Fas ligand	Homo sapiens	64-68
10711676-11	2000	Glutathione and NAC completely abrogated tBH-induced increase in FasL and Fas expression and apoptosis.	tert-Butylhydroperoxide	41-44	X-linked Kx blood group	Homo sapiens	16-19
10711676-5	2000	To investigate the possible involvement of Fas-mediated apoptosis in oxidative killing of hRPE cells, the effects of the oxidant tert-butylhydroperoxide (tBH) on the expression of FasL and Fas were studied.	tert-Butylhydroperoxide	129-152	Fas ligand	Homo sapiens	180-184
10711676-5	2000	To investigate the possible involvement of Fas-mediated apoptosis in oxidative killing of hRPE cells, the effects of the oxidant tert-butylhydroperoxide (tBH) on the expression of FasL and Fas were studied.	tert-Butylhydroperoxide	154-157	Fas ligand	Homo sapiens	180-184
10711676-11	2000	Glutathione and NAC completely abrogated tBH-induced increase in FasL and Fas expression and apoptosis.	tert-Butylhydroperoxide	41-44	Fas ligand	Homo sapiens	65-69
10711676-12	2000	Blocking FasL and Fas interaction by ZB4 inhibited tBH-induced apoptosis, but only partially.	tert-Butylhydroperoxide	51-54	Fas ligand	Homo sapiens	9-13
10623477-4	2000	The activation of the repair enzyme poly(ADP-ribose)polymerase (PARP) following DNA damage by tBOOH induced a dramatic drop in both NAD(+) and ATP.	tert-Butylhydroperoxide	94-99	poly (ADP-ribose) polymerase 1	Rattus norvegicus	36-62
10644761-3	2000	BCP preferentially reduced linoleic acid hydroperoxide rather than H(2)O(2) and t-butyl hydroperoxide with the use of thioredoxin as an in vivo immediate electron donor.	tert-Butylhydroperoxide	80-101	thioredoxin	Homo sapiens	118-129
10644761-9	2000	Bcp null mutant grew more slowly than its wild type in aerobic culture and showed the hypersensitivity toward various oxidants such as H(2)O(2), t-butyl hydroperoxide, and linoleic acid hydroperoxide.	tert-Butylhydroperoxide	145-166	opsin 1, short wave sensitive	Homo sapiens	0-3
10623477-4	2000	The activation of the repair enzyme poly(ADP-ribose)polymerase (PARP) following DNA damage by tBOOH induced a dramatic drop in both NAD(+) and ATP.	tert-Butylhydroperoxide	94-99	poly (ADP-ribose) polymerase 1	Rattus norvegicus	64-68
10623477-5	2000	The inhibition of PARP by 3-aminobenzamide enhanced DNA damage by tBOOH, restored NAD(+) and ATP levels, but did not result in better survival against cell killing by tBOOH.	tert-Butylhydroperoxide	66-71	poly (ADP-ribose) polymerase 1	Rattus norvegicus	18-22
10525122-4	1999	In order to prove this, we investigated the effect of M-CSF on the oxidative injury caused by tert-butyl hydroperoxide (tbOOH) to mouse peritoneal macrophages and U937/J774 cell lines.	tert-Butylhydroperoxide	94-118	colony stimulating factor 1 (macrophage)	Mus musculus	54-59
10525122-4	1999	In order to prove this, we investigated the effect of M-CSF on the oxidative injury caused by tert-butyl hydroperoxide (tbOOH) to mouse peritoneal macrophages and U937/J774 cell lines.	tert-Butylhydroperoxide	120-125	colony stimulating factor 1 (macrophage)	Mus musculus	54-59
10569637-5	1999	When subjected to acute oxidant stress by exposure to ferric/ascorbic acid or tert-butylhydroperoxide (tert-BHT), catalase activity showed a steeper decline compared with GSH-PX.	tert-Butylhydroperoxide	78-101	catalase	Homo sapiens	114-122
10550628-9	1999	tert-Butylhydroperoxide, a substrate of PHGPX, induced csa mRNA transcripts after only 2 h, and abolished the differential response between salt-sensitive and salt-tolerant cells.	tert-Butylhydroperoxide	0-23	glutathione peroxidase 4	Homo sapiens	40-45
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	tert-Butylhydroperoxide	165-189	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10602300-3	1999	The reactivity of lipoxygenase with peroxides in the gallic acid solidus hydroperoxide system was in the order of methylethyl hydroperoxide (MEK-OOH, 4800 cps) > tert-butyl hydroperoxide (tert-BuOOH, 607 cps) > hydrogen peroxide (H(2)O(2), 455 cps) > cumene hydroperoxide (cumene-OOH, 261 cps).	tert-Butylhydroperoxide	191-201	linoleate 9S-lipoxygenase-4	Glycine max	18-30
10501214-1	1999	The results presented in this study indicate that the toxic response brought about by increasing concentrations of tert-butylhydroperoxide in CHP100 cells was mitigated significantly by exogenously added nitric oxide donors via a cyclic GMP-independent mechanism.	tert-Butylhydroperoxide	115-138	5'-nucleotidase, cytosolic II	Homo sapiens	237-240
10501214-5	1999	Release of the cation from ryanodine-sensitive Ca2+ stores was causally linked with the caffeine/nitric oxide-mediated enhancement of tert-butylhydroperoxide toxicity.	tert-Butylhydroperoxide	134-157	carbonic anhydrase 2	Homo sapiens	47-50
10496679-8	1999	Disruption of the E-cadherin/catenin complex by tBHP, but not DA, correlated with enhanced tyrosine phosphorylation of beta-catenin.	tert-Butylhydroperoxide	48-52	cadherin 1	Mus musculus	18-28
10496679-8	1999	Disruption of the E-cadherin/catenin complex by tBHP, but not DA, correlated with enhanced tyrosine phosphorylation of beta-catenin.	tert-Butylhydroperoxide	48-52	catenin (cadherin associated protein), beta 1	Mus musculus	119-131
10440245-5	1999	Sensitivity of hRPE cells to oxidative stress was determined using tert-butylhydroperoxide as the oxidative agent.	tert-Butylhydroperoxide	67-90	ribulose-5-phosphate-3-epimerase	Homo sapiens	15-19
10498809-5	1999	In the presence of oxidizing agents (tert-butyl hydroperoxide and diamide), sub-optimal concentrations of uncoupler induce rapid cyclosporin-sensitive release of Ca2+.	tert-Butylhydroperoxide	37-61	carbonic anhydrase 2	Rattus norvegicus	162-165
10533589-9	1999	The tBHP-induced currents resembled Trp-related currents in terms of cation selectivity, La3+ sensitivity and lack of voltage dependence.	tert-Butylhydroperoxide	4-8	transient receptor potential	Drosophila melanogaster	36-39
10220511-9	1999	Furthermore, TBHP, which is known to increase hepatocyte mitochondrial ROS production, also increased UCP-2 messenger RNA levels.	tert-Butylhydroperoxide	13-17	uncoupling protein 2	Rattus norvegicus	102-107
10102293-2	1999	METHODS: Cultured hRPE cells were treated with different concentrations of a chemical oxidant, t-butylhydroperoxide (tBH), for different periods of time.	tert-Butylhydroperoxide	95-115	ribulose-5-phosphate-3-epimerase	Homo sapiens	18-22
10231168-5	1999	t-Butyl hydroperoxide (100 mg/kg, IP) given to rats 30 min before administration of LPS enhanced LPS-mediated upregulation of iNOS mRNA and TNFalpha protein in AM and BAL fluid.	tert-Butylhydroperoxide	0-21	nitric oxide synthase 2	Rattus norvegicus	126-130
10231168-5	1999	t-Butyl hydroperoxide (100 mg/kg, IP) given to rats 30 min before administration of LPS enhanced LPS-mediated upregulation of iNOS mRNA and TNFalpha protein in AM and BAL fluid.	tert-Butylhydroperoxide	0-21	tumor necrosis factor	Rattus norvegicus	140-148
10102293-2	1999	METHODS: Cultured hRPE cells were treated with different concentrations of a chemical oxidant, t-butylhydroperoxide (tBH), for different periods of time.	tert-Butylhydroperoxide	117-120	ribulose-5-phosphate-3-epimerase	Homo sapiens	18-22
10102293-6	1999	RESULTS: t-Butylhydroperoxide caused time- and dose-dependent activation of apoptosis in hRPE, indicated by characteristic morphologic changes; TUNEL-positive labeling; phosphatidylserine (PS) exposure; and procaspase 3, poly(ADP-ribose)polymerase, lamin, and tubulin cleavage.	tert-Butylhydroperoxide	9-29	ribulose-5-phosphate-3-epimerase	Homo sapiens	89-93
10102293-6	1999	RESULTS: t-Butylhydroperoxide caused time- and dose-dependent activation of apoptosis in hRPE, indicated by characteristic morphologic changes; TUNEL-positive labeling; phosphatidylserine (PS) exposure; and procaspase 3, poly(ADP-ribose)polymerase, lamin, and tubulin cleavage.	tert-Butylhydroperoxide	9-29	caspase 3	Homo sapiens	207-219
10102293-6	1999	RESULTS: t-Butylhydroperoxide caused time- and dose-dependent activation of apoptosis in hRPE, indicated by characteristic morphologic changes; TUNEL-positive labeling; phosphatidylserine (PS) exposure; and procaspase 3, poly(ADP-ribose)polymerase, lamin, and tubulin cleavage.	tert-Butylhydroperoxide	9-29	poly(ADP-ribose) polymerase 1	Homo sapiens	221-247
10102293-6	1999	RESULTS: t-Butylhydroperoxide caused time- and dose-dependent activation of apoptosis in hRPE, indicated by characteristic morphologic changes; TUNEL-positive labeling; phosphatidylserine (PS) exposure; and procaspase 3, poly(ADP-ribose)polymerase, lamin, and tubulin cleavage.	tert-Butylhydroperoxide	9-29	lamin A/C	Homo sapiens	249-254
10102293-8	1999	CONCLUSIONS: Results indicate that tBH can induce apoptosis in hRPE, probably by triggering the mitochondrial permeability transition, which results in swelling and release of mitochondrial intermembrane proteins.	tert-Butylhydroperoxide	35-38	ribulose-5-phosphate-3-epimerase	Homo sapiens	63-67
9922216-0	1999	Gene transfer of mitochondrially targeted glutathione reductase protects H441 cells from t-butyl hydroperoxide-induced oxidant stresses.	tert-Butylhydroperoxide	89-110	glutathione-disulfide reductase	Homo sapiens	42-63
9917323-2	1999	Selective oxidation of G-CSF by H2O2 and t-butyl hydroperoxide leads to generation of different oxidized forms.	tert-Butylhydroperoxide	41-62	colony stimulating factor 3	Homo sapiens	23-28
9854036-9	1999	Recombinant mouse GSTT1-1 exhibited glutathione peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide, but was inactive towards a range of secondary lipid-peroxidation products, such as the trans-alk-2-enals and trans,trans-alka-2,4-dienals.	tert-Butylhydroperoxide	101-122	glutathione S-transferase, theta 1	Mus musculus	18-25
10377253-2	1999	This study investigates the role of cyclophilin-A in necrotic cell death, induced by "chemical ischaemia" and by t-butylhydroperoxide.	tert-Butylhydroperoxide	113-133	peptidylprolyl isomerase A	Rattus norvegicus	36-49
10377253-8	1999	However, cyclophilin-A-suppressed cells were markedly more sensitive to t-butylhydroperoxide.	tert-Butylhydroperoxide	72-92	peptidylprolyl isomerase A	Rattus norvegicus	9-22
9862285-2	1998	Cytochrome P-450-dependent lipid peroxidation was induced by carbon tetrachloride or tert-butylhydroperoxide and was evident by an increase in thiobarbituric acid-reactive substances (TBA-RS) and oxygen consumption.	tert-Butylhydroperoxide	85-108	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
9653065-5	1998	Activation of PLA2, PLC, and PLD by three oxidants, hydrogen peroxide (H2O2), tert-butyl hydroperoxide (t-BOOH) and 2,2"-azobis(2-amidinopropane)dihydrochloride (AAPH) also was measured and compared to that of LOP.	tert-Butylhydroperoxide	78-102	phospholipase A2 group IB	Homo sapiens	14-18
9873835-3	1998	Treatment with TBHP significantly reduced glutathione content and glutathione reductase activity, and increased glutathione peroxidase activity, indicating that TBHP induced oxidative stress in the HepG2 cells.	tert-Butylhydroperoxide	15-19	glutathione-disulfide reductase	Homo sapiens	66-87
9753651-2	1998	We observed that canonical inducers of MPT (Ca2+, t-butyl hydroperoxide, atractyloside) induce a swelling-dependent release of cytochrome c, and that osmotic support of mitochondria with PEG-1000 abolishes mitochondrial swelling, protein release, and cytochrome c release by these inducers.	tert-Butylhydroperoxide	50-71	cytochrome c, somatic	Homo sapiens	127-139
9753651-2	1998	We observed that canonical inducers of MPT (Ca2+, t-butyl hydroperoxide, atractyloside) induce a swelling-dependent release of cytochrome c, and that osmotic support of mitochondria with PEG-1000 abolishes mitochondrial swelling, protein release, and cytochrome c release by these inducers.	tert-Butylhydroperoxide	50-71	cytochrome c, somatic	Homo sapiens	251-263
9741587-5	1998	Transfectants over expressing GSHPx were also significantly more resistant to exposure to either L-DOPA or t-butyl hydroperoxide than mock-transfected cells.	tert-Butylhydroperoxide	107-128	glutathione peroxidase 1	Rattus norvegicus	30-35
9724415-2	1998	While exposure to the mutagens UVC, 4NQO and H2O2 induced expression of the RNR2-lacZ and RNR3-lacZ fusion constructs in two WT strains, treatment with the two oxidative stressors tBOOH and paraquat did not.	tert-Butylhydroperoxide	180-185	ribonucleotide-diphosphate reductase subunit RNR2	Saccharomyces cerevisiae S288C	76-80
9724415-2	1998	While exposure to the mutagens UVC, 4NQO and H2O2 induced expression of the RNR2-lacZ and RNR3-lacZ fusion constructs in two WT strains, treatment with the two oxidative stressors tBOOH and paraquat did not.	tert-Butylhydroperoxide	180-185	ribonucleotide-diphosphate reductase subunit RNR3	Saccharomyces cerevisiae S288C	90-94
9582315-6	1998	Prior ER stress induces expression of the ER stress proteins Grp78, Grp94, and calreticulin and rendered cells resistant to cell death caused by a subsequent TBHP challenge.	tert-Butylhydroperoxide	158-162	heat shock protein family A (Hsp70) member 5	Homo sapiens	61-66
9582315-6	1998	Prior ER stress induces expression of the ER stress proteins Grp78, Grp94, and calreticulin and rendered cells resistant to cell death caused by a subsequent TBHP challenge.	tert-Butylhydroperoxide	158-162	heat shock protein 90 beta family member 1	Homo sapiens	68-73
9582315-6	1998	Prior ER stress induces expression of the ER stress proteins Grp78, Grp94, and calreticulin and rendered cells resistant to cell death caused by a subsequent TBHP challenge.	tert-Butylhydroperoxide	158-162	calreticulin	Homo sapiens	79-91
9582315-7	1998	Expressing antisense RNA targeted to grp78 prevents grp78 induction sensitized cells to TBHP and disrupted their ability to develop cellular tolerance.	tert-Butylhydroperoxide	88-92	heat shock protein family A (Hsp70) member 5	Homo sapiens	37-42
9626567-4	1998	Cells with high-level expression of human G6PD were 2.3 (H6) to 3.7 (H7) times more resistant to TBH than control cells.	tert-Butylhydroperoxide	97-100	glucose-6-phosphate dehydrogenase	Homo sapiens	42-46
9582315-7	1998	Expressing antisense RNA targeted to grp78 prevents grp78 induction sensitized cells to TBHP and disrupted their ability to develop cellular tolerance.	tert-Butylhydroperoxide	88-92	heat shock protein family A (Hsp70) member 5	Homo sapiens	52-57
9626567-9	1998	In this study, overexpression of human G6PD in NIH3T3 cells had different effects on the toxicity of TBH vs. paraquat.	tert-Butylhydroperoxide	101-104	glucose-6-phosphate dehydrogenase	Homo sapiens	39-43
9626567-10	1998	Reduction of NADP+ to NADPH by G6PD protects cells from oxidative damage by TBH, but appears to enhance the toxicity of paraquat.	tert-Butylhydroperoxide	76-79	glucose-6-phosphate dehydrogenase 2	Mus musculus	31-35
9598989-1	1998	Upon induction of permeability transition with different agents (Ca2+, tert-butyl hydroperoxide, atractyloside), mouse hepatocyte mitochondria manifest a disruption of outer membrane integrity leading to the release of cytochrome c and apoptosis-inducing factor (AIF), two proteins which are involved in programmed cell death (apoptosis).	tert-Butylhydroperoxide	71-95	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	236-261
9582315-8	1998	In addition, overexpressing calreticulin, another ER chaperone and Ca2+-binding protein, also protected cells against TBHP.	tert-Butylhydroperoxide	118-122	calreticulin	Homo sapiens	28-40
9626567-0	1998	Effects of G6PD overexpression in NIH3T3 cells treated with tert-butyl hydroperoxide or paraquat.	tert-Butylhydroperoxide	60-84	glucose-6-phosphate dehydrogenase 2	Mus musculus	11-15
9646329-9	1998	These results indicate that t-butylhydroperoxide stimulates Cl-secretion via activation of phospholipase A2 and subsequent production of cyclooxygenase metabolities by Ca(2+)-dependent and -independent mechanisms.	tert-Butylhydroperoxide	28-48	phospholipase A2 group IB	Rattus norvegicus	91-107
9598989-1	1998	Upon induction of permeability transition with different agents (Ca2+, tert-butyl hydroperoxide, atractyloside), mouse hepatocyte mitochondria manifest a disruption of outer membrane integrity leading to the release of cytochrome c and apoptosis-inducing factor (AIF), two proteins which are involved in programmed cell death (apoptosis).	tert-Butylhydroperoxide	71-95	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	263-266
9465036-3	1998	Although Bcl-2 had no effect on the respiration rate of isolated mitochondria, it prevented both Deltapsi loss and the permeability transition (PT) induced by various reagents, including Ca2+, H2O2, and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	203-227	BCL2 apoptosis regulator	Homo sapiens	9-14
9587962-2	1998	METHODS: Oxidized leptin derivatives were prepared in the presence of H2O2 and t-butylhydroperoxide, separated by RP-HPLC, and characterized by peptide mapping and LC/MS.	tert-Butylhydroperoxide	79-99	leptin	Homo sapiens	18-24
9587962-7	1998	In 48 mM t-butylhydroperoxide, the pseudo first-order rate constants, k1 and k69, were 1.5 x 10(-3) and 2.3 x 10(-4) min-1.	tert-Butylhydroperoxide	9-29	CD59 molecule (CD59 blood group)	Homo sapiens	117-122
9465036-8	1998	Furthermore, Bcl-2 enhanced H+ efflux but not K+ flux after treatment of mitochondria with Ca2+ or tert-butyl hydroperoxide.	tert-Butylhydroperoxide	99-123	BCL2 apoptosis regulator	Homo sapiens	13-18
9385440-0	1997	Stimulation of cytosolic phospholipase A2-catalyzed arachidonic acid liberation by low dose tert-butyl hydroperoxide without an influence on the enzyme activity in rabbit platelets.	tert-Butylhydroperoxide	92-116	cytosolic phospholipase A2	Oryctolagus cuniculus	15-41
9385440-5	1997	However, with a membrane fraction, arachidonic acid liberation catalyzed by the partially purified cPLA2 was synergistically enhanced by BHP and FeSO4.	tert-Butylhydroperoxide	137-140	cytosolic phospholipase A2	Oryctolagus cuniculus	99-104
9325328-13	1997	t-Butyl hydroperoxide, which induces lipid peroxidation, activated NF-kappaB.	tert-Butylhydroperoxide	0-21	nuclear factor kappa B subunit 1	Homo sapiens	67-76
9221835-4	1997	Net TGF-beta1 production in injured RPTC increased 1.7- and 3.2-fold on Days 1 and 2, respectively, and returned to control levels 4 days following TBHP treatment.	tert-Butylhydroperoxide	148-152	transforming growth factor beta 1	Homo sapiens	4-13
9363753-12	1997	Furthermore, with the three protein components (Nbs2 reductase, mt-Trx, and SP-22) NADPH was oxidized in the presence of hydrogen peroxide or tert-butyl hydroperoxide.	tert-Butylhydroperoxide	142-166	thioredoxin 2	Bos taurus	64-70
9221835-5	1997	An anti-TGF-beta antibody increased monolayer confluence to 50% and DNA content 1.3-fold 4 days after TBHP exposure.	tert-Butylhydroperoxide	102-106	transforming growth factor beta 1	Homo sapiens	8-16
9221835-8	1997	The results demonstrate that TBHP-induced injury increases net TGF-beta1 production in RPTC and that autocrine TGF-beta1 inhibits regeneration of the monolayer by potentiating cellular injury and monolayer deterioration.	tert-Butylhydroperoxide	29-33	transforming growth factor beta 1	Homo sapiens	63-72
9439155-0	1997	Effect of Ca2+ channel blockers, external Ca2+ and phospholipase A2 inhibitors on t-butylhydroperoxide-induced lipid peroxidation and toxicity in rat liver slices.	tert-Butylhydroperoxide	82-102	phospholipase A2 group IB	Rattus norvegicus	51-67
9439155-10	1997	CONCLUSIONS: These results suggest that t-BHP induces cell injury by lipid peroxidation-dependent and -independent mechanisms which can be partially prevented by Ca2+ channel blockers and PLA2 inhibitors.	tert-Butylhydroperoxide	40-45	phospholipase A2 group IB	Rattus norvegicus	188-192
9042969-2	1997	Cultured K562 cells, which maintain a stable cytosolic labile iron pool (LIP) of < 0.5 microM, underwent distinct changes after short exposures to transferrin (Tf) followed by t-butyl hydroperoxide (TBHP): (a) rise in LIP, detectable fluorimetrically; (b) increased lipid peroxidation and (c) eventual cell death.	tert-Butylhydroperoxide	202-206	transferrin	Homo sapiens	150-161
9178189-3	1997	This study examines the activity of N-acetylcysteine, a known antioxidant, in the protection of PMN exposed in-vitro to the chemoattractant peptide fMet-Leu-Phe (FMLP), the protein kinase C activator phorbol myristate acetate or the lipid peroxidation promoter t-butyl hydroperoxide.	tert-Butylhydroperoxide	261-282	formyl peptide receptor 1	Homo sapiens	148-160
8917415-4	1996	The interaction of t-BHP with hemoglobin (Hb) and methemoglobin (MetHb) caused the production of superoxide (O2-) and hydrogen peroxide (H2O2).	tert-Butylhydroperoxide	19-24	hemoglobin subunit gamma 2	Homo sapiens	50-63
9342597-9	1997	Apparently, TMZ seems to behave like trifluoperazine (TFP), a phospholipase A2 inhibitor that, under our experimental conditions, inhibits the mitochondrial swelling induced by Ca2+ and t-BH with an IC50 value of 25 +/- 10 microM.	tert-Butylhydroperoxide	186-190	phospholipase A2 group IB	Homo sapiens	62-78
9372861-4	1997	Iron donors (diferric transferrin, Fe-PIH or their combination) and t-butyl hydroperoxide (t-BuOOH) had the opposite effect on GSHPx-1 gene transcription in run-on experiments.	tert-Butylhydroperoxide	68-89	glutathione peroxidase 1	Mus musculus	127-134
9029824-0	1996	Involvement of a protease in tert-butylhydroperoxide-mediated activation of Ca2+ ATPase in microsomes of pulmonary smooth muscle.	tert-Butylhydroperoxide	29-52	carbonic anhydrase 2	Bos taurus	76-87
8914622-0	1996	Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity.	tert-Butylhydroperoxide	87-110	metallothionein 1	Mus musculus	17-34
8917415-4	1996	The interaction of t-BHP with hemoglobin (Hb) and methemoglobin (MetHb) caused the production of superoxide (O2-) and hydrogen peroxide (H2O2).	tert-Butylhydroperoxide	19-24	hemoglobin subunit gamma 2	Homo sapiens	65-70
8917415-5	1996	The differential direct effect of t-BHP on Hb and MetHb was investigated by taking their spectra in the presence or absence of cytochrome C.	tert-Butylhydroperoxide	34-39	hemoglobin subunit gamma 2	Homo sapiens	50-55
8809353-1	1996	Purified liver microsomal vitamin D 25-hydroxylase, a cytochrome P450, catalyzes 25-hydroxylation of vitamin D3 in the absence of NADPH and NADPH-cytochrome P450 reductase by using t-butyl hydroperoxide as electron donors.	tert-Butylhydroperoxide	181-202	cytochrome P450 family 2 subfamily R member 1	Homo sapiens	26-50
8679570-9	1996	Binding of CyP to the mitochondrial membrane was increased by treatment with tert-butylhydroperoxide, phenylarsine oxide, and diamide and by hypoosmotic KCl medium.	tert-Butylhydroperoxide	77-100	peptidylprolyl isomerase G	Homo sapiens	11-14
8706660-4	1996	Cross-linking of mitochondrial dithiols with arsenite or phenylarsine oxide, or treatment with tert-butylhydroperoxide leading to complete oxidation of glutathione, increased the sensitivity of MTP opening to Ca2+.	tert-Butylhydroperoxide	95-118	microsomal triglyceride transfer protein	Rattus norvegicus	194-197
8809353-4	1996	The rates of 25-hydroxylation of 1 alpha-hydroxyvitamin D3 and 5 beta-cholestane-3 alpha, 7 alpha-diol catalyzed by 25-hydroxylase were significantly higher when the reaction proceeded in the presence of NADPH/NADPH-cytochrome P450 reductase than in the presence of t-butyl hydroperoxide.	tert-Butylhydroperoxide	266-287	2,4-dienoyl-CoA reductase 1	Homo sapiens	204-209
8809353-4	1996	The rates of 25-hydroxylation of 1 alpha-hydroxyvitamin D3 and 5 beta-cholestane-3 alpha, 7 alpha-diol catalyzed by 25-hydroxylase were significantly higher when the reaction proceeded in the presence of NADPH/NADPH-cytochrome P450 reductase than in the presence of t-butyl hydroperoxide.	tert-Butylhydroperoxide	266-287	cytochrome p450 oxidoreductase	Homo sapiens	210-241
8809353-9	1996	Oxidation of dopamine to aminochrome catalyzed by the peroxidase activity of cytochrome P-450 1A2 was observed in the presence of t-butyl hydroperoxide.	tert-Butylhydroperoxide	130-151	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-97
8662189-5	1996	In addition, the GSH 1-disruption strain is sensitive to oxidative stress caused by H2O2 and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	93-117	glutamate--cysteine ligase	Saccharomyces cerevisiae S288C	17-22
8631767-5	1996	Studies performed to analyze levels of c-fos mRNA, a gene whose expression is modulated by redox state, demonstrated that only high, apoptotic concentrations of TGF-beta (2.5 ng/ml) produced an increase in the mRNA levels of this gene, the level of induction being similar to that found when cells were incubated in the presence of tert-butyl hydroperoxide.	tert-Butylhydroperoxide	332-356	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	39-44
8619496-2	1996	The results showed that two of the five methionine residues in rIFN-gamma were susceptible to oxidation by TBHP, while three of the five methionines in rt-PA were found to be oxidizable.	tert-Butylhydroperoxide	107-111	interferon gamma	Rattus norvegicus	63-73
8631767-5	1996	Studies performed to analyze levels of c-fos mRNA, a gene whose expression is modulated by redox state, demonstrated that only high, apoptotic concentrations of TGF-beta (2.5 ng/ml) produced an increase in the mRNA levels of this gene, the level of induction being similar to that found when cells were incubated in the presence of tert-butyl hydroperoxide.	tert-Butylhydroperoxide	332-356	transforming growth factor beta 1	Homo sapiens	161-169
8717415-4	1996	Inhibition of phospholipase A2 by dibucaine and Ca2+ activated proteases by antipain and leupeptin also reduced t-BHP induced swelling.	tert-Butylhydroperoxide	112-117	phospholipase A2 group IB	Rattus norvegicus	14-30
8579366-8	1996	Thus, the modulation by tBOOH appears to be largely dependent upon the changes in [Ca2+]i. Receptor mediated stimulation of the respiratory burst (ADP stimulation) involves release of Ca2+ from the inositol-1,4,5-triphosphate (IP3)-sensitive pool in the endoplasmic reticulum.	tert-Butylhydroperoxide	24-29	carbonic anhydrase 2	Rattus norvegicus	83-86
8579366-8	1996	Thus, the modulation by tBOOH appears to be largely dependent upon the changes in [Ca2+]i. Receptor mediated stimulation of the respiratory burst (ADP stimulation) involves release of Ca2+ from the inositol-1,4,5-triphosphate (IP3)-sensitive pool in the endoplasmic reticulum.	tert-Butylhydroperoxide	24-29	carbonic anhydrase 2	Rattus norvegicus	184-187
8579366-9	1996	Comparisons were made of the effects of thapsigargin (TG), an endoplasmic reticulum Ca-ATPase inhibitor, with tBOOH on release of intracellular Ca2+ and the respiratory burst.	tert-Butylhydroperoxide	110-115	carbonic anhydrase 2	Rattus norvegicus	144-147
8579366-12	1996	Thus, the effect of tBOOH upon the respiratory burst is dependent upon the release of Ca2+ and the release of Ca2+ occurs from a non-IP3-dependent pool.	tert-Butylhydroperoxide	20-25	carbonic anhydrase 2	Rattus norvegicus	86-89
8579366-12	1996	Thus, the effect of tBOOH upon the respiratory burst is dependent upon the release of Ca2+ and the release of Ca2+ occurs from a non-IP3-dependent pool.	tert-Butylhydroperoxide	20-25	carbonic anhydrase 2	Rattus norvegicus	110-113
8566604-6	1996	RESULTS: The protease inhibitor Cbz-Leu-Leu-Tyr-CHN2 inhibited both calpain-like protease activity and induction of the MMPT by Ca2+ and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	137-161	chimerin 2	Rattus norvegicus	48-52
8566604-8	1996	The protease inhibitor Cbz-Leu-Leu-Tyr-CHN2 also delayed the onset of mitochondrial depolarization and cell necrosis during treatment of rat hepatocytes with tert-butyl hydroperoxide, a model of oxidative stress relevant to human disease.	tert-Butylhydroperoxide	158-182	chimerin 2	Rattus norvegicus	39-43
7786021-3	1995	We show here that NO delivered from the NO donor compound, PAPA/NO (NH2(C3H6)(N[N(O)NO](C3H7)), protects Chinese hamster V79 lung fibroblasts from the cytotoxicity of t-butyl hydroperoxide and cumene hydroperoxide.	tert-Butylhydroperoxide	167-188	pappalysin 1	Homo sapiens	59-63
8555249-6	1996	Treatment of unirradiated cultures with the potent oxidant tert-butyl hydroperoxide (500 microM) also increased cPLA2 synthesis and phosphorylation, suggesting that oxidative injury is an important regulator of cPLA2 synthesis.	tert-Butylhydroperoxide	59-83	phospholipase A2 group IVA	Homo sapiens	112-117
8555249-6	1996	Treatment of unirradiated cultures with the potent oxidant tert-butyl hydroperoxide (500 microM) also increased cPLA2 synthesis and phosphorylation, suggesting that oxidative injury is an important regulator of cPLA2 synthesis.	tert-Butylhydroperoxide	59-83	phospholipase A2 group IVA	Homo sapiens	211-216
8524851-5	1995	On the other hand tert-butyl hydroperoxide, another generator of reactive oxygen species, removed the fast inactivation processes of Kv1.4 and Kv3.4 but did not alter other channels.	tert-Butylhydroperoxide	18-42	potassium voltage-gated channel subfamily A member 4 S homeolog	Xenopus laevis	133-138
7548200-0	1995	Phospholipase A stimulation in tumor cells by subtoxic concentration of tert-butyl hydroperoxide.	tert-Butylhydroperoxide	72-96	phospholipase A and acyltransferase 1	Mus musculus	0-15
7548200-4	1995	When P815 cells were treated with 50 microM of tert-butyl hydroperoxide, a significant stimulation (x 2.5) of phospholipase A was observed after 15 min of treatment.	tert-Butylhydroperoxide	47-71	phospholipase A and acyltransferase 1	Mus musculus	110-125
7548200-7	1995	These results show that, in the tumor cell line P815, the disturbance of phospholipid and arachidonate metabolism induced by t-BHP is linked to phospholipase A, the activation of which seems independent of oxidative stress.	tert-Butylhydroperoxide	125-130	phospholipase A and acyltransferase 1	Mus musculus	144-159
7674549-9	1995	The cytotoxicity of t-butylhydroperoxide decreased when 1 mM and 5 mM of ascorbic acid was added to the culture media with catalase pretreatment (p = 0.0277).	tert-Butylhydroperoxide	20-40	catalase	Homo sapiens	123-131
7779866-1	1995	Murine leukemia L1210 cells rendered deficient in glutathione peroxidase (GPX) and phospholipid hydroperoxide glutathione peroxidase (PHGPX) by Se deprivation (L.Se(-) cells) were found to be more sensitive to tert-butyl hydroperoxide (t-BuOOH) cytotoxicity than Se-replete controls (L.Se(+) cells).	tert-Butylhydroperoxide	210-234	glutathione peroxidase 4	Mus musculus	83-132
7785054-8	1995	Unlike EGF, IGF-1 or insulin treatment produced a small increase in confluency following TBHP exposure.	tert-Butylhydroperoxide	89-93	insulin-like growth factor I	Oryctolagus cuniculus	12-17
7785054-8	1995	Unlike EGF, IGF-1 or insulin treatment produced a small increase in confluency following TBHP exposure.	tert-Butylhydroperoxide	89-93	insulin	Oryctolagus cuniculus	21-28
7759524-2	1995	The mechanism for the reaction of cytochrome c with t-butyl hydroperoxide and cumene hydroperoxide was investigated.	tert-Butylhydroperoxide	52-73	cytochrome c, somatic	Homo sapiens	34-46
7763299-5	1995	The rate of NAD+ deletion induced by tert-butyl hydroperoxide (500 microM) and 2,3-dimethoxy-1,4-naphthoquinone (50 microM) was reduced by preincubating the hepatocytes for 1 hr with either 3-aminobenzamide (20 mM), nicotinamide (10 mM) or theophylline (7.5 mM), potent inhibitors of poly(ADP-ribose)polymerase.	tert-Butylhydroperoxide	37-61	poly (ADP-ribose) polymerase 1	Rattus norvegicus	284-310
7820887-11	1995	In addition to the generalized damage of red cell membrane, tertbutylhydroperoxide was found to induce a specific alteration of the skeletal network at the horizontal junction sites involving spectrin, actin, and protein 4.1 and thus to modify the cytoskeletal assembly.	tert-Butylhydroperoxide	60-82	erythrocyte membrane protein band 4.1	Homo sapiens	213-224
18623277-3	1995	Furthermore, the rate of catalase-catalyzed production of tert-butanol from tert-butyl hydroperoxide increases more than 400-fold upon transition from aqueous buffer to ethanol as the reaction medium.	tert-Butylhydroperoxide	76-100	catalase	Bos taurus	25-33
18623277-4	1995	The mechanistic rationale for this striking effect is that in aqueous buffer the rate-limiting step of the enzymatic process involves the reduction of catalase"s compound I by tert-butyl hydroperoxide.	tert-Butylhydroperoxide	176-200	catalase	Bos taurus	151-159
18623277-6	1995	In solvents, such as acetonitrile or tetrahydrofuran, which themselves are not oxidizable by compound I, catalase catalyzes the oxidation of numerous primary and secondary alcohols with tert-butyl hydroperoxide to the corresponding aldehydes or ketones.	tert-Butylhydroperoxide	186-210	catalase	Bos taurus	105-113
7531495-1	1995	The ability of murine macrophage nitric oxide synthase (NOS) to utilize peroxides in place of O2 and NADPH was investigated using hydrogen peroxide (H2O2), tert-butylhydroperoxide, and cumene hydroperoxide with both L-arginine and NG-hydroxy-L-arginine (L-NHA) as substrates.	tert-Butylhydroperoxide	156-179	nitric oxide synthase 1, neuronal	Mus musculus	33-54
8195015-8	1994	RESULTS: EL4 cell apoptosis can be induced by tert-butyl hydroperoxide or the glutathione oxidant SR-4077.	tert-Butylhydroperoxide	46-70	epilepsy 4	Mus musculus	9-12
7533613-16	1995	The intracellular "hydroperoxide donor" tert-butylhydroperoxide in the concentration range of 0.03-3 mM inhibited insulin release stimulated by the nutrient secretagogues glucose and L-arginine.	tert-Butylhydroperoxide	40-63	insulin	Homo sapiens	114-121
7533613-24	1995	The mechanism underlying the secretion promoting action of tert-butylhydroperoxide on IBMX-induced insulin release is probably linked to intracellular Ca2+-perturbations affecting exocytosis.8.	tert-Butylhydroperoxide	59-82	insulin	Homo sapiens	99-106
7865484-8	1994	RESULTS: Effect of t-butylhydroperioxide(t-BHP), a potent oxidant, on organic anion p-amminohippurate(PAH) uptake was studied in rabbit renal cortical slices.	tert-Butylhydroperoxide	41-46	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	102-105
7865484-9	1994	t-BHP inhibited irreversibly PAH and organic cation tetraethylammonium(TEA) uptake in a dose dependent manner with IC50 of approximately 1.0 and 0.85 mM, respectively.	tert-Butylhydroperoxide	0-5	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	29-32
7865484-10	1994	The efflux rate constant pf PAH was not altered by the presence of 1 mM t-BHP, indicating that the inhibitory effect of t-BHP on the steady-state accumulation of PAH is due primary to the reduction in the influx of PAH across the basolateral membrane.	tert-Butylhydroperoxide	120-125	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	28-31
7865484-10	1994	The efflux rate constant pf PAH was not altered by the presence of 1 mM t-BHP, indicating that the inhibitory effect of t-BHP on the steady-state accumulation of PAH is due primary to the reduction in the influx of PAH across the basolateral membrane.	tert-Butylhydroperoxide	120-125	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	162-165
7865484-10	1994	The efflux rate constant pf PAH was not altered by the presence of 1 mM t-BHP, indicating that the inhibitory effect of t-BHP on the steady-state accumulation of PAH is due primary to the reduction in the influx of PAH across the basolateral membrane.	tert-Butylhydroperoxide	120-125	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	162-165
7865484-11	1994	The kinetic analysis showed that 1mM t-BHP caused a significant reduction in the maximum rate of PAH influx(Vmax) from 1.54 +/- 0.74 to 0.72 +/- 0.54 umol/g/10 min without an effect on Km, indicating that t-BHP depressed PAH influx across the basolateral membrane by reducing the number or turnover rate of active carrier for PAH transport, but not by altering substrate affinity of the carrier.	tert-Butylhydroperoxide	37-42	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	97-100
7865484-11	1994	The kinetic analysis showed that 1mM t-BHP caused a significant reduction in the maximum rate of PAH influx(Vmax) from 1.54 +/- 0.74 to 0.72 +/- 0.54 umol/g/10 min without an effect on Km, indicating that t-BHP depressed PAH influx across the basolateral membrane by reducing the number or turnover rate of active carrier for PAH transport, but not by altering substrate affinity of the carrier.	tert-Butylhydroperoxide	37-42	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	221-224
7865484-11	1994	The kinetic analysis showed that 1mM t-BHP caused a significant reduction in the maximum rate of PAH influx(Vmax) from 1.54 +/- 0.74 to 0.72 +/- 0.54 umol/g/10 min without an effect on Km, indicating that t-BHP depressed PAH influx across the basolateral membrane by reducing the number or turnover rate of active carrier for PAH transport, but not by altering substrate affinity of the carrier.	tert-Butylhydroperoxide	37-42	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	221-224
7865484-11	1994	The kinetic analysis showed that 1mM t-BHP caused a significant reduction in the maximum rate of PAH influx(Vmax) from 1.54 +/- 0.74 to 0.72 +/- 0.54 umol/g/10 min without an effect on Km, indicating that t-BHP depressed PAH influx across the basolateral membrane by reducing the number or turnover rate of active carrier for PAH transport, but not by altering substrate affinity of the carrier.	tert-Butylhydroperoxide	205-210	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	97-100
7865484-13	1994	t-BHP caused an increase in LDH release and lipid peroxidation in a dose-dependent manner, which were highly correlated with changes in PAH uptake.	tert-Butylhydroperoxide	0-5	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	136-139
7865484-14	1994	CONCLUSION: These results suggest that t-BHP inhibition of PAH uptake is attributed to renal tubular cell damage and lipid peroxidation plays an important role in the inhibitory effect of t-BHP on PAH transport in rabbit proximl tubules.	tert-Butylhydroperoxide	39-44	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	59-62
7865484-14	1994	CONCLUSION: These results suggest that t-BHP inhibition of PAH uptake is attributed to renal tubular cell damage and lipid peroxidation plays an important role in the inhibitory effect of t-BHP on PAH transport in rabbit proximl tubules.	tert-Butylhydroperoxide	188-193	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	197-200
8195159-2	1994	We examined the sensitivity of NIH 3T3 cells transfected with a plasmid containing mouse metallothionein-I gene (NIH3T3/MT) to the membrane permeant oxidant, tert-butyl hydroperoxide (tBH).	tert-Butylhydroperoxide	158-182	metallothionein 1	Mus musculus	89-106
8195159-2	1994	We examined the sensitivity of NIH 3T3 cells transfected with a plasmid containing mouse metallothionein-I gene (NIH3T3/MT) to the membrane permeant oxidant, tert-butyl hydroperoxide (tBH).	tert-Butylhydroperoxide	184-187	metallothionein 1	Mus musculus	89-106
8161215-2	1994	A similar group of S-thiolated proteins including carbonic anhydrase III was observed in cells treated with t-butyl hydroperoxide, menadione, or stimulated neutrophils.	tert-Butylhydroperoxide	108-129	carbonic anhydrase 3	Homo sapiens	50-72
7910007-0	1994	Differential roles of Glu318 and Thr319 in cytochrome P450 1A2 catalysis supported by NADPH-cytochrome P450 reductase and tert-butyl hydroperoxide.	tert-Butylhydroperoxide	122-146	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	43-62
7910007-1	1994	The kinetic values for 7-ethoxycoumarin (7-EC) hydroxylation have been obtained in both the NADPH-cytochrome P450 reductase- and tert-butyl hydroperoxide (TBHP)-supported systems for several Glu318 and Thr319 mutants of cytochrome P450 1A2.	tert-Butylhydroperoxide	155-159	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	220-239
8012294-1	1994	Normal human erythrocytes suspended in isotonic saline at 0.5 haematocrit displayed, after 30 min exposure to 1 mM tert-butylhydroperoxide at 37 degrees C, a marked increase of NADPH, while the concentration of the other adenine nucleotides was almost unchanged.	tert-Butylhydroperoxide	115-138	2,4-dienoyl-CoA reductase 1	Homo sapiens	177-182
8005526-7	1994	AH2 is also the most effective antioxidant in preventing microsomal LPO mediated by tert-butylhydroperoxide or the chain propagating species LOO., generated from 2,2"-azobis (2-amidinopropane) hydrochloride.	tert-Butylhydroperoxide	84-107	zinc finger RANBP2-type containing 3	Homo sapiens	0-3
7512201-3	1994	SP2/0 derived murine hybridoma cells were treated with 4 concentrations of tert.-butyl hydroperoxide for varying periods of time.	tert-Butylhydroperoxide	75-100	Sp2 transcription factor	Mus musculus	0-5
8106395-11	1994	Conversely, treatment of unirradiated cultures with the potent oxidant tert-butyl-hydroperoxide (100 microM) increased both PGE2 synthesis and EGF-R phosphorylation.	tert-Butylhydroperoxide	71-95	epidermal growth factor	Homo sapiens	143-146
8608322-6	1994	Incubation of tBHP (75, 100, or 125 microM) with PAEC decreased cell viability, increased LDH release, and elevated MDH production.	tert-Butylhydroperoxide	14-18	LDH	Bos taurus	90-93
7814299-2	1994	To elucidate the electrophysiological mechanisms underlying these arrhythmias, the effects of tert butyl hydroperoxide (TBH) on the Na+ current (INa) in isolated feline ventricular myocytes were studied using whole-cell patch clamp techniques under 100% O2 bubbling.	tert-Butylhydroperoxide	94-118	internexin neuronal intermediate filament protein alpha	Homo sapiens	145-148
7814299-2	1994	To elucidate the electrophysiological mechanisms underlying these arrhythmias, the effects of tert butyl hydroperoxide (TBH) on the Na+ current (INa) in isolated feline ventricular myocytes were studied using whole-cell patch clamp techniques under 100% O2 bubbling.	tert-Butylhydroperoxide	120-123	internexin neuronal intermediate filament protein alpha	Homo sapiens	145-148
7814299-4	1994	Twenty millimoles TBH shifted the steady-state inactivation curve for INa from -77.4 +/- 1.7 to -81.3 +/- 1.8 mV when measured at INa half inhibition voltage (P < 0.01, n = 7), but did not affect the slope factor.	tert-Butylhydroperoxide	18-21	internexin neuronal intermediate filament protein alpha	Homo sapiens	70-73
7814299-4	1994	Twenty millimoles TBH shifted the steady-state inactivation curve for INa from -77.4 +/- 1.7 to -81.3 +/- 1.8 mV when measured at INa half inhibition voltage (P < 0.01, n = 7), but did not affect the slope factor.	tert-Butylhydroperoxide	18-21	internexin neuronal intermediate filament protein alpha	Homo sapiens	130-133
7814299-6	1994	These findings suggest that lipid peroxidation in the membrane by TBH reduces INa conductance and voltage-dependent INa availability, most likely as a result of structural damage to the Na+ channels.	tert-Butylhydroperoxide	66-69	internexin neuronal intermediate filament protein alpha	Homo sapiens	78-81
7814299-6	1994	These findings suggest that lipid peroxidation in the membrane by TBH reduces INa conductance and voltage-dependent INa availability, most likely as a result of structural damage to the Na+ channels.	tert-Butylhydroperoxide	66-69	internexin neuronal intermediate filament protein alpha	Homo sapiens	116-119
8241252-1	1993	Incubation of human red blood cells (RBCs) with t-butyl hydroperoxide (tBHP) resulted in inhibition of the Ca-pump ATPase.	tert-Butylhydroperoxide	48-69	dynein axonemal heavy chain 8	Homo sapiens	115-121
8278572-4	1993	We found that internucleosomal DNA fragmentation, characteristics of apoptosis, can result from treatment of EL4 and F9 cells with agents that have diverse modes of action: tert-butyl hydroperoxide, diazenedicarboxylic acid bis(N,N-piperidide), and etoposide.	tert-Butylhydroperoxide	173-197	epilepsy 4	Mus musculus	109-112
8241252-1	1993	Incubation of human red blood cells (RBCs) with t-butyl hydroperoxide (tBHP) resulted in inhibition of the Ca-pump ATPase.	tert-Butylhydroperoxide	71-75	dynein axonemal heavy chain 8	Homo sapiens	115-121
8241252-4	1993	Pseudo-first-order rate constants (Ca-pump ATPase rate constants) were lower in the presence of tBHP versus controls.	tert-Butylhydroperoxide	96-100	dynein axonemal heavy chain 8	Homo sapiens	43-49
8241252-5	1993	Incubation of RBCs with tBHP resulted in both a time- and concentration-dependent inhibition of the Ca-pump ATPase (IC50 approximately 1 mM).	tert-Butylhydroperoxide	24-28	dynein axonemal heavy chain 8	Homo sapiens	108-114
8241252-6	1993	Incubation of RBCs with tBHP also resulted in decreased oxyhemoglobin, increased methemoglobin and increased thiobarbituric acid reactive substances (TBARS).	tert-Butylhydroperoxide	24-28	hemoglobin subunit gamma 2	Homo sapiens	81-94
8241252-9	1993	Both butylated hydroxytoluene and stobadine prevented the formation of TBARS and were partially effective in protecting the Ca-pump ATPase from tBHP-induced inhibition.	tert-Butylhydroperoxide	144-148	dynein axonemal heavy chain 8	Homo sapiens	132-138
8241252-13	1993	In the presence of mercaptosuccinate, a potent inhibitor of glutathione peroxidase, the ability of dithiothreitol to protect the Ca-pump ATPase from tBHP-induced inhibition was abolished.	tert-Butylhydroperoxide	149-153	dynein axonemal heavy chain 8	Homo sapiens	137-143
8241252-15	1993	These results may be interpreted to suggest that inhibition of the Ca-pump ATPase in intact RBCs occurs as a result of tBHP-induced oxidant stress and subsequent lipid peroxidation which can be prevented by certain antioxidants including butylated hydroxytoluene, stobadine, and thiol-containing compounds such as dithiothreitol.	tert-Butylhydroperoxide	119-123	dynein axonemal heavy chain 8	Homo sapiens	75-81
8394353-14	1993	In rat liver cells, the increases in [Ca2+]i induced by TBHP and thimerosal were prevented by microinjection of the cells with the (1,4,5)IP3 receptor antagonist heparin.	tert-Butylhydroperoxide	56-60	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	138-150
8392529-3	1993	The formation of methyl free radicals during the metabolism of cumene and t-butyl-hydroperoxide was shown by the electron spin resonance-spin trapping technique.	tert-Butylhydroperoxide	74-95	spindlin 1	Homo sapiens	122-126
8392529-3	1993	The formation of methyl free radicals during the metabolism of cumene and t-butyl-hydroperoxide was shown by the electron spin resonance-spin trapping technique.	tert-Butylhydroperoxide	74-95	spindlin 1	Homo sapiens	137-141
8428933-6	1993	Similar substrate specificities are found for GSHPx-1 and GSHPx-GI; they both catalyze the reduction of H2O2, tert-butyl hydroperoxide, cumene hydroperoxide, and linoleic acid hydroperoxide with glutathione, but not of phosphatidylcholine hydroperoxide.	tert-Butylhydroperoxide	110-134	glutathione peroxidase 1	Homo sapiens	46-53
8503874-1	1993	Oxidant stress induced by t-butyl hydroperoxide (t-BuOOH) inhibits bradykinin-stimulated Ca2+ signalling in vascular endothelial cells.	tert-Butylhydroperoxide	26-47	kininogen 1	Homo sapiens	67-77
8503892-0	1993	Role of a membrane-associated serine esterase in the oxidant activation of phospholipase A2 by t-butyl hydroperoxide.	tert-Butylhydroperoxide	95-116	LOC104974671	Bos taurus	75-91
8503892-1	1993	Exposure of bovine pulmonary-arterial endothelial cells to the oxidant lipid t-butyl hydroperoxide (t-Bu-OOH) increases cell-membrane-associated phospholipase A2 (PLA2) activity and stimulates arachidonic acid (AA) release.	tert-Butylhydroperoxide	77-98	LOC104974671	Bos taurus	145-161
8503892-1	1993	Exposure of bovine pulmonary-arterial endothelial cells to the oxidant lipid t-butyl hydroperoxide (t-Bu-OOH) increases cell-membrane-associated phospholipase A2 (PLA2) activity and stimulates arachidonic acid (AA) release.	tert-Butylhydroperoxide	77-98	LOC104974671	Bos taurus	163-167
8496623-9	1993	The activity of glucose-6-phosphate dehydrogenase was decreased 50% following treatment for 5 h with 700 microM CHP or tBHP, whereas H2O2 treatment caused a brief 15% decline, followed by recovery.	tert-Butylhydroperoxide	119-123	glucose-6-phosphate dehydrogenase	Homo sapiens	16-49
8318649-1	1993	Electron spin resonance spin trapping was utilized to investigate the generation of free radicals from cumene hydroperoxide (cumene-OOH), tert-butyl hydroperoxide (tert-butyl-OOH), and H2O2 at pH 7.2 by Co(II) in the presence of cysteinyl and histidyl chelating agents.	tert-Butylhydroperoxide	138-162	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	203-209
8428933-6	1993	Similar substrate specificities are found for GSHPx-1 and GSHPx-GI; they both catalyze the reduction of H2O2, tert-butyl hydroperoxide, cumene hydroperoxide, and linoleic acid hydroperoxide with glutathione, but not of phosphatidylcholine hydroperoxide.	tert-Butylhydroperoxide	110-134	glutathione peroxidase 2	Homo sapiens	58-66
8380970-3	1993	Catalase-depleted mitochondria were more susceptible to H2O2-dependent lipid peroxidation and had similar extents of tert-butyl hydroperoxide (t-BuOOH)-induced lipid peroxidation compared with control mitochondria.	tert-Butylhydroperoxide	117-141	catalase	Rattus norvegicus	0-8
8434945-1	1993	Incubation of 4% bovine serum albumin (BSA) with 1 mM tert-butyl hydroperoxide (t-BOOH) resulted in a peak of chemiluminescence followed by decay to a steady-state level of 18 counts per second above control.	tert-Butylhydroperoxide	54-78	albumin	Homo sapiens	24-37
1472074-8	1992	Northern blot analysis showed approximately 3- and 2-fold increases, respectively, in class alpha and mu GST mRNA levels, following the tert-butyl hydroperoxide treatment.	tert-Butylhydroperoxide	136-160	hematopoietic prostaglandin D synthase	Rattus norvegicus	105-108
1492102-0	1992	Effect of tert-butyl hydroperoxide on cyclooxygenase and lipoxygenase metabolism of arachidonic acid in rabbit platelets.	tert-Butylhydroperoxide	10-34	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	57-69
1449518-6	1992	Measurement of the intracellular Ca2+ pools showed an early depletion of the mitochondrial Ca2+ pool in hepatocytes exposed to 3,5-Me2-NAPQI, tBH or cumene hydroperoxide; this loss was prevented by CsA.	tert-Butylhydroperoxide	142-145	carbonic anhydrase 2	Homo sapiens	33-36
1449518-6	1992	Measurement of the intracellular Ca2+ pools showed an early depletion of the mitochondrial Ca2+ pool in hepatocytes exposed to 3,5-Me2-NAPQI, tBH or cumene hydroperoxide; this loss was prevented by CsA.	tert-Butylhydroperoxide	142-145	carbonic anhydrase 2	Homo sapiens	91-94
1472074-9	1992	The results of the present investigation show that alterations in Ca2+ homeostasis produced by either Ca2+ ionophore A23187 or tert-butyl hydroperoxide treatment of hepatocytes enhanced the expression of GST isozymes in primary cultured rat hepatocytes.	tert-Butylhydroperoxide	127-151	hematopoietic prostaglandin D synthase	Rattus norvegicus	204-207
1621823-7	1992	After incubation with tert-butyl hydroperoxide, a time-dependent inhibition of the agonist-stimulated changes in [Ca2+]i is observed.	tert-Butylhydroperoxide	22-46	carbonic anhydrase 2	Homo sapiens	114-117
1627644-8	1992	The transformed cells expressed a 36.4 kDa polypeptide (the 317 amino acid sequence of APEX nuclease headed by the N-terminal decapeptide derived from the part of pUC18 sequence), and were less sensitive to methylmethanesulfonate and tert-butyl-hydroperoxide than the parent cells.	tert-Butylhydroperoxide	234-258	apurinic/apyrimidinic endonuclease 1	Mus musculus	87-100
1317326-1	1992	When rat liver mitochondria are treated with tert-butyl hydroperoxide (TBHP) in the presence of the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO), electron paramagnetic resonance (EPR) signals are detected attributable to spin adducts resulting from the trapping of methyl, tert-butoxyl, and tert-butylperoxyl radicals.	tert-Butylhydroperoxide	71-75	telomerase reverse transcriptase	Rattus norvegicus	45-49
1596871-3	1992	Compounds likely to promote transformation (nickel sulphate, benzyl peroxide and t-butyl hydroperoxide) were also effective and apparently selective, proliferin inducers in C3H/10T1/2 and primary murine fibroblasts.	tert-Butylhydroperoxide	81-102	prolactin family 2, subfamily c, member 2	Mus musculus	150-160
1891491-2	1991	This extract exerted a significant hepatoprotection of tert-butyl hydroperoxide-induced hepatotoxicity in isolated rat hepatocytes (in vitro technique) by reducing the lipid peroxidation and the enzymatic leakage of LDH; this in vitro efficacy was reinforced by a significant hepatoprotection on CCl4-induced hepatotoxicity in mice (in vivo technique), the plant extract reducing the enzymatic leakage of ALAT.	tert-Butylhydroperoxide	55-79	C-C motif chemokine ligand 4	Rattus norvegicus	296-300
1715020-3	1991	We show here that yeast strains lacking Apn1 (generated by targeted gene disruption or deletion-replacement) are hypersensitive to both oxidative (hydrogen peroxide and t-butylhydroperoxide) and alkylating (methyl- and ethylmethane sulfonate) agents that damage DNA.	tert-Butylhydroperoxide	169-189	DNA-(apurinic or apyrimidinic site) lyase APN1	Saccharomyces cerevisiae S288C	40-44
1878370-2	1991	By treatment of NPM-labeled membranes with 100 microM ascorbic acid/10 microM Fe2+ in the presence of various concentrations of tert-butyl hydroperoxide (t-BuOOH), the fluorescence intensity of the complex decreased with the formation of conjugated diene, depending on the hydroperoxide concentration.	tert-Butylhydroperoxide	128-152	nucleophosmin 1	Homo sapiens	16-19
1996698-2	1991	Bradykinin-stimulated uptake of 45Ca2+ was determined after cells were incubated with the membrane-permeant oxidant t-butylhydroperoxide (0.4 mM) for various durations.	tert-Butylhydroperoxide	116-136	kininogen 1	Bos taurus	0-10
2015106-2	1991	Exposure to tert-butylhydroperoxide induced, most markedly in G6PD- and PK-deficient erythrocytes, a reduction of protein bands 1, 2, 2.1, 3, 4.1, 4.2, and 5, with the appearance of high-molecular-weight aggregates and of "new" polypeptide components in the 29- to 23-kDa region and with a marked increase of membrane-bound globin.	tert-Butylhydroperoxide	12-35	glucose-6-phosphate dehydrogenase	Homo sapiens	62-74
1996698-3	1991	t-Butylhydroperoxide increased uptake of 45Ca2+ under basal conditions and significantly decreased bradykinin-stimulated uptake in a time-dependent manner through incubation periods of 2 h. Preincubation of cells with 1,3-bis(chloroethyl)-1-nitrosourea markedly reduced bradykinin-stimulated uptake in cells subsequently treated with t-butylhydroperoxide.	tert-Butylhydroperoxide	0-20	kininogen 1	Bos taurus	99-109
1996698-3	1991	t-Butylhydroperoxide increased uptake of 45Ca2+ under basal conditions and significantly decreased bradykinin-stimulated uptake in a time-dependent manner through incubation periods of 2 h. Preincubation of cells with 1,3-bis(chloroethyl)-1-nitrosourea markedly reduced bradykinin-stimulated uptake in cells subsequently treated with t-butylhydroperoxide.	tert-Butylhydroperoxide	0-20	kininogen 1	Bos taurus	270-280
1996698-3	1991	t-Butylhydroperoxide increased uptake of 45Ca2+ under basal conditions and significantly decreased bradykinin-stimulated uptake in a time-dependent manner through incubation periods of 2 h. Preincubation of cells with 1,3-bis(chloroethyl)-1-nitrosourea markedly reduced bradykinin-stimulated uptake in cells subsequently treated with t-butylhydroperoxide.	tert-Butylhydroperoxide	334-354	kininogen 1	Bos taurus	99-109
1996698-5	1991	t-Butylhydroperoxide initially decreased bradykinin-stimulated efflux of 45Ca2+ but had no effect on 86Rb+ efflux.	tert-Butylhydroperoxide	0-20	kininogen 1	Bos taurus	41-51
2143896-7	1990	Oxidation of pyridine nucleotides, induced by tbh through the concerted action of glutathione peroxidase, glutathione reductase and the energy-linked transhydrogenase, was not affected by up to 50 microM-HNE.	tert-Butylhydroperoxide	46-49	glutathione-disulfide reductase	Rattus norvegicus	106-127
1663060-2	1991	When tert-butyl hydroperoxide was incubated with either PMNs or purified myeloperoxidase, peroxyl, alkoxyl, and alkyl radicals were trapped by the spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO).	tert-Butylhydroperoxide	5-29	myeloperoxidase	Homo sapiens	73-88
2254581-1	1990	Treatment of rats with 100 mg kg-1 t-butyl hydroperoxide led to an enhanced ethane exhalation as a marker of in vivo lipid peroxidation, as well as a moderate hepatoxicity as evidenced by a rise in plasma activities of liver-specific enzymes (glutamate-pyruvate transaminase and sorbitol dehydrogenase) and an increase in hepatic calcium content.	tert-Butylhydroperoxide	35-56	sorbitol dehydrogenase	Rattus norvegicus	279-301
2313294-4	1990	Respiratory inhibition induced by Ca2+ and tBOOH does not involve pyruvate dehydrogenase (PDH) inhibition since PDH flux increased linearly with tBOOH concentration (R = 0.96).	tert-Butylhydroperoxide	145-150	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	112-115
2164422-4	1990	In contrast to the significant depression of A23187-stimulated formation of 5-lipoxygenase products by 10 microM tBOOH, cellular adenosine triphosphate (ATP) was unchanged.	tert-Butylhydroperoxide	113-118	arachidonate 5-lipoxygenase	Rattus norvegicus	76-90
2164422-6	1990	The results indicate that inhibition of 5-lipoxygenase pathway products in macrophages treated with tBOOH did not occur by depletion of cellular ATP levels.	tert-Butylhydroperoxide	100-105	arachidonate 5-lipoxygenase	Rattus norvegicus	40-54
2350179-1	1990	Liposome-encapsulated (LSOD) or free (FSOD), human recombinant Cu-Zn superoxide dismutase prevented the killing of cultured rat hepatocytes by tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	143-167	superoxide dismutase 1	Homo sapiens	63-89
2350179-1	1990	Liposome-encapsulated (LSOD) or free (FSOD), human recombinant Cu-Zn superoxide dismutase prevented the killing of cultured rat hepatocytes by tert-butyl hydroperoxide (TBHP).	tert-Butylhydroperoxide	169-173	superoxide dismutase 1	Homo sapiens	63-89
2313294-5	1990	Calcium potentiated tBOOH-induced mitochondrial NAD(P)H oxidation and shifted the redox state of cytochrome b from 67 to 47% reduced.	tert-Butylhydroperoxide	20-25	mitochondrially encoded cytochrome b	Homo sapiens	97-109
24221893-1	1990	Freshly isolated rainbow trout hepatocytes were exposed to tert-butyl hydroperoxide (BuOOH), a substrate for glutathione peroxidase.	tert-Butylhydroperoxide	59-83	glutathione peroxidase 1	Oncorhynchus mykiss	109-131
2295640-7	1990	The substrate-dependent pattern of tBOOH-induced NAD(P)H (NADH plus NADPH) and cytochrome b oxidation was similar to that seen for respiratory inhibition and Ca2+ efflux suggesting that NAD(P)H may be a common factor in both responses.	tert-Butylhydroperoxide	35-40	2,4-dienoyl-CoA reductase 1	Homo sapiens	68-73
2295640-7	1990	The substrate-dependent pattern of tBOOH-induced NAD(P)H (NADH plus NADPH) and cytochrome b oxidation was similar to that seen for respiratory inhibition and Ca2+ efflux suggesting that NAD(P)H may be a common factor in both responses.	tert-Butylhydroperoxide	35-40	mitochondrially encoded cytochrome b	Homo sapiens	79-91
33810344-0	2021	ACTH(6-9)PGP Peptide Protects SH-SY5Y Cells from H2O2, tert-Butyl Hydroperoxide, and Cyanide Cytotoxicity via Stimulation of Proliferation and Induction of Prosurvival-Related Genes.	tert-Butylhydroperoxide	55-79	phosphoglycolate phosphatase	Homo sapiens	9-12
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	cytochrome b-245 beta chain	Rattus norvegicus	46-50
34885789-6	2021	The interaction of the expressed Lb with oxidative and nitrosative stress inducers (nitrosoglutathione, tert-butyl hydroperoxide, and benzylviologen) was studied by enzymatic methods and spectrophotometry.	tert-Butylhydroperoxide	104-128	leghemoglobin A	Glycine max	33-35
2294097-2	1990	Changes in [Ca2+]i upon stimulation with bradykinin were measured after incubation of cells with the chemical oxidant tert-butyl hydroperoxide (0.4 mM) for various times.	tert-Butylhydroperoxide	118-142	kininogen 1	Bos taurus	41-51
2294097-6	1990	However, incubation of carmustine-treated cells with tert-butyl hydroperoxide for 30 min dramatically reduced both bradykinin-stimulated release of Ca2+ from internal stores and influx of Ca2+ from the extracellular space.	tert-Butylhydroperoxide	53-77	kininogen 1	Bos taurus	115-125
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	NADPH oxidase 4	Rattus norvegicus	55-59
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	forkhead box O1	Rattus norvegicus	125-130
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	forkhead box O3	Rattus norvegicus	132-137
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	forkhead box O4	Rattus norvegicus	139-144
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	superoxide dismutase 2	Rattus norvegicus	146-151
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	catalase	Rattus norvegicus	156-164
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	24-28	matrix metallopeptidase 13	Rattus norvegicus	229-235
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	cytochrome b-245 beta chain	Rattus norvegicus	46-50
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	NADPH oxidase 4	Rattus norvegicus	55-59
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	forkhead box O1	Rattus norvegicus	125-130
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	forkhead box O3	Rattus norvegicus	132-137
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	forkhead box O4	Rattus norvegicus	139-144
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	superoxide dismutase 2	Rattus norvegicus	146-151
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	catalase	Rattus norvegicus	156-164
34772597-10	2021	With the stimulation of TBHP, the contents of NOX2 and NOX4 in NPCs increased significantly, and the antioxidant proteins of FOXO1, FOXO3, FOXO4, MnSOD and Catalase and the matrix proteins of Aggrecan decreased remarkably, while MMP-13 significantly increased after TBHP intervention.	tert-Butylhydroperoxide	266-270	matrix metallopeptidase 13	Rattus norvegicus	229-235
34670095-1	2021	A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters using a Co(II)/TBHP/(Me2SiH)2O catalytic system.	tert-Butylhydroperoxide	135-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	128-134
34803685-0	2021	Paeoniflorin Suppresses TBHP-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells via the Nrf2/HO-1 Signaling Pathway and Improves Skin Flap Survival.	tert-Butylhydroperoxide	24-28	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
34777682-11	2021	In particular, ECH was shown to suppress tert-Butyl hydroperoxide- (TBHP-) induced OS and subsequently lower the levels of p-PERK/PERK, GRP78, ATF4, p-eIF2alpha/eIF2alpha, and CHOP in vitro.	tert-Butylhydroperoxide	41-65	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	130-134
34777682-11	2021	In particular, ECH was shown to suppress tert-Butyl hydroperoxide- (TBHP-) induced OS and subsequently lower the levels of p-PERK/PERK, GRP78, ATF4, p-eIF2alpha/eIF2alpha, and CHOP in vitro.	tert-Butylhydroperoxide	41-65	heat shock protein 5	Mus musculus	136-141
34777682-11	2021	In particular, ECH was shown to suppress tert-Butyl hydroperoxide- (TBHP-) induced OS and subsequently lower the levels of p-PERK/PERK, GRP78, ATF4, p-eIF2alpha/eIF2alpha, and CHOP in vitro.	tert-Butylhydroperoxide	41-65	activating transcription factor 4	Mus musculus	143-147
34777682-11	2021	In particular, ECH was shown to suppress tert-Butyl hydroperoxide- (TBHP-) induced OS and subsequently lower the levels of p-PERK/PERK, GRP78, ATF4, p-eIF2alpha/eIF2alpha, and CHOP in vitro.	tert-Butylhydroperoxide	41-65	eukaryotic translation initiation factor 2A	Mus musculus	151-160
34777682-11	2021	In particular, ECH was shown to suppress tert-Butyl hydroperoxide- (TBHP-) induced OS and subsequently lower the levels of p-PERK/PERK, GRP78, ATF4, p-eIF2alpha/eIF2alpha, and CHOP in vitro.	tert-Butylhydroperoxide	41-65	eukaryotic translation initiation factor 2A	Mus musculus	161-170
34777682-11	2021	In particular, ECH was shown to suppress tert-Butyl hydroperoxide- (TBHP-) induced OS and subsequently lower the levels of p-PERK/PERK, GRP78, ATF4, p-eIF2alpha/eIF2alpha, and CHOP in vitro.	tert-Butylhydroperoxide	41-65	DNA-damage inducible transcript 3	Mus musculus	176-180
34777682-15	2021	Conclusion: In summary, our findings indicate that ECH can inhibit ER stress and ECM degradation by upregulating Sirt1 in mouse chondrocytes treated with TBHP.	tert-Butylhydroperoxide	154-158	sirtuin 1	Mus musculus	113-118
34556628-4	2021	In vitro, the results revealed that FGF21 administration alleviated apoptosis, senescence, and extracellular matrix (ECM) catabolism of the chondrocytes induced by tert-butyl hydroperoxide (TBHP) by mediating autophagy flux.	tert-Butylhydroperoxide	164-188	fibroblast growth factor 21	Homo sapiens	36-41
34426259-6	2021	Besides, this HPL significantly protected against tert-butyl hydroperoxide (TBHP)-induced oxidative stress as evidenced by increasing CEC viability, decreased cell death and reactive oxygen species formation, and enhanced antioxidant capacity.	tert-Butylhydroperoxide	50-74	galectin 1	Homo sapiens	14-17
34426259-6	2021	Besides, this HPL significantly protected against tert-butyl hydroperoxide (TBHP)-induced oxidative stress as evidenced by increasing CEC viability, decreased cell death and reactive oxygen species formation, and enhanced antioxidant capacity.	tert-Butylhydroperoxide	76-80	galectin 1	Homo sapiens	14-17
34520197-5	2021	Treatment with the free phenolic fraction of extruded hempseed hull (100 mg/mL) alleviated tert-butyl hydroperoxide"s (25 muM) negative effects on cell viability, intracellular malondialdehyde levels, apoptosis induction, glutathione S-transferase, and glutathione levels.	tert-Butylhydroperoxide	91-115	glutathione S-transferase kappa 1	Homo sapiens	222-247
34556628-4	2021	In vitro, the results revealed that FGF21 administration alleviated apoptosis, senescence, and extracellular matrix (ECM) catabolism of the chondrocytes induced by tert-butyl hydroperoxide (TBHP) by mediating autophagy flux.	tert-Butylhydroperoxide	190-194	fibroblast growth factor 21	Homo sapiens	36-41
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	heme oxygenase 1	Mus musculus	112-128
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	heme oxygenase 1	Mus musculus	130-134
34356378-6	2021	In addition, GLP-1 could protect NIH3T3 cells against tert-butyl hydroperoxide (tBHP)-induced oxidative damage by increasing catalase (CAT) and glutathione peroxidase (GSH-Px) activities, elevating the glutathione/oxidized glutathione (GSH/GSSG) ratio, and decreasing the malondialdehyde (MDA) level.	tert-Butylhydroperoxide	54-78	glucagon	Mus musculus	13-18
34575438-4	2021	In this study, xanthohumol prevented tert-butyl hydroperoxide-induced loss of cell viability in human corneal epithelial (HCE-T) cells in a dose-dependent manner and resulted in a significant increase in expression of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), the master regulator of phase II endogenous antioxidant enzymes.	tert-Butylhydroperoxide	37-61	NFE2 like bZIP transcription factor 2	Homo sapiens	243-286
34575438-4	2021	In this study, xanthohumol prevented tert-butyl hydroperoxide-induced loss of cell viability in human corneal epithelial (HCE-T) cells in a dose-dependent manner and resulted in a significant increase in expression of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), the master regulator of phase II endogenous antioxidant enzymes.	tert-Butylhydroperoxide	37-61	NFE2 like bZIP transcription factor 2	Homo sapiens	288-292
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	NAD(P)H dehydrogenase, quinone 1	Mus musculus	136-166
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	210-261
34511883-9	2021	0.025 and 0.05 microM BM prevented TBHP-induced mitochondrial damage and apoptosis in chondrocytes BM activated heme oxygenase-1 (HO-1)/NADPH quinone oxidoreductase 1 (NOQ1) signaling pathway through targeting nuclear factor erythroid derived-2-related factor 2 (Nrf2).	tert-Butylhydroperoxide	35-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	263-267
34409026-6	2021	TNFalpha treatment potentiated the brain endothelial erythrophagocytosis of tBHP-RBCs in vitro.	tert-Butylhydroperoxide	76-80	tumor necrosis factor	Mus musculus	0-8
34178129-5	2021	Tert-butyl hydroperoxide (TBHP) was used to induce apoptosis in NPs on the second passage, while overexpression of FGF-18 in NPs attenuated TBHP-induced apoptosis.	tert-Butylhydroperoxide	140-144	fibroblast growth factor 18	Homo sapiens	115-121
34303734-8	2021	Subsequent incubation with N-Acetyl-L-cysteine (NAC, 1 mM) reestablished GSH content and reverted concomitantly the alteration in Mrp2 localization and function induced by TBH.	tert-Butylhydroperoxide	172-175	ATP binding cassette subfamily C member 2	Rattus norvegicus	130-134
34356378-6	2021	In addition, GLP-1 could protect NIH3T3 cells against tert-butyl hydroperoxide (tBHP)-induced oxidative damage by increasing catalase (CAT) and glutathione peroxidase (GSH-Px) activities, elevating the glutathione/oxidized glutathione (GSH/GSSG) ratio, and decreasing the malondialdehyde (MDA) level.	tert-Butylhydroperoxide	54-78	catalase	Mus musculus	125-133
34356378-6	2021	In addition, GLP-1 could protect NIH3T3 cells against tert-butyl hydroperoxide (tBHP)-induced oxidative damage by increasing catalase (CAT) and glutathione peroxidase (GSH-Px) activities, elevating the glutathione/oxidized glutathione (GSH/GSSG) ratio, and decreasing the malondialdehyde (MDA) level.	tert-Butylhydroperoxide	80-84	glucagon	Mus musculus	13-18
34356378-6	2021	In addition, GLP-1 could protect NIH3T3 cells against tert-butyl hydroperoxide (tBHP)-induced oxidative damage by increasing catalase (CAT) and glutathione peroxidase (GSH-Px) activities, elevating the glutathione/oxidized glutathione (GSH/GSSG) ratio, and decreasing the malondialdehyde (MDA) level.	tert-Butylhydroperoxide	80-84	catalase	Mus musculus	125-133
34356378-6	2021	In addition, GLP-1 could protect NIH3T3 cells against tert-butyl hydroperoxide (tBHP)-induced oxidative damage by increasing catalase (CAT) and glutathione peroxidase (GSH-Px) activities, elevating the glutathione/oxidized glutathione (GSH/GSSG) ratio, and decreasing the malondialdehyde (MDA) level.	tert-Butylhydroperoxide	80-84	catalase	Mus musculus	135-138
34335275-6	2021	In vitro experiments have shown that Sin may inhibit chondrocyte apoptosis induced by tert-butyl hydroperoxide (TBHP); at the same time, it might also inhibit the production of MMP13 and promote the production of aggrecan and collagen II.	tert-Butylhydroperoxide	112-116	telomerase reverse transcriptase	Mus musculus	86-90
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	AKT serine/threonine kinase 1	Rattus norvegicus	17-20
34604405-5	2021	Methods: Prx activity was estimated by incubating samples in suitable concentrations of 1,4-dithio-DL-threitol (DTT) and hydrogen peroxide (H2O2) or t-Butyl hydroperoxide (t-BOOH), as the substrates.	tert-Butylhydroperoxide	149-170	periaxin	Homo sapiens	9-12
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	NFE2 like bZIP transcription factor 2	Rattus norvegicus	21-25
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	AKT serine/threonine kinase 1	Rattus norvegicus	119-122
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-167
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	NFE2 like bZIP transcription factor 2	Rattus norvegicus	169-173
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	202-207
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	heme oxygenase 1	Rattus norvegicus	213-229
34183021-11	2021	TI activated the Akt/Nrf2 pathway to promote the expression of antioxidant-related proteins such as phosphorylation of Akt, nuclear factor erythroid 2 related factor 2 (Nrf2), quinone oxidoreductase-1 (NQO-1) and heme oxygenase-1 (HO-1) expression in t-BHP-stimulated H9c2 cells.	tert-Butylhydroperoxide	251-256	heme oxygenase 1	Rattus norvegicus	231-235
34211633-9	2021	The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro.	tert-Butylhydroperoxide	77-101	NFE2 like bZIP transcription factor 2	Rattus norvegicus	48-52
34211633-9	2021	The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro.	tert-Butylhydroperoxide	77-101	sirtuin 3	Rattus norvegicus	53-58
34211633-9	2021	The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro.	tert-Butylhydroperoxide	104-108	NFE2 like bZIP transcription factor 2	Rattus norvegicus	48-52
34211633-9	2021	The results demonstrated that activation of the Nrf2/Sirt3 pathway inhibited tert-butyl hydroperoxide- (TBHP-) induced apoptosis and mitochondrial dysfunction in vitro.	tert-Butylhydroperoxide	104-108	sirtuin 3	Rattus norvegicus	53-58
34211633-10	2021	In addition to apoptosis, upregulation of the Nrf2/Sirt3 pathway induced by t-BHQ restored TBHP-induced autophagic flux disturbances.	tert-Butylhydroperoxide	91-95	NFE2 like bZIP transcription factor 2	Rattus norvegicus	46-50
35624896-0	2022	Protective Effect of Alpinia oxyphylla Fruit against tert-Butyl Hydroperoxide-Induced Toxicity in HepG2 Cells via Nrf2 Activation and Free Radical Scavenging and Its Active Molecules.	tert-Butylhydroperoxide	53-77	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
35381215-13	2022	After receiving TBHP or TBHP-MitoQ treatment, ELISA and immunofluorescence assays were used to evaluate the level of VEGFA secretion from BV2 cells.	tert-Butylhydroperoxide	24-28	vascular endothelial growth factor A	Mus musculus	117-122
35435532-14	2022	Mechanistically, we confirmed that the miR-130b-3p regulated the ATG14 and PRKAA1 directly and the knockdown of the ATG14 or PRKAA1 as well as the treatment of autophagy inhibitor blockaded the autophagic flux and reversed the protective effects of miR-130b-3p inhibition in the TBHP-induced human NP cells.	tert-Butylhydroperoxide	279-283	autophagy related 14	Homo sapiens	65-70
35435532-14	2022	Mechanistically, we confirmed that the miR-130b-3p regulated the ATG14 and PRKAA1 directly and the knockdown of the ATG14 or PRKAA1 as well as the treatment of autophagy inhibitor blockaded the autophagic flux and reversed the protective effects of miR-130b-3p inhibition in the TBHP-induced human NP cells.	tert-Butylhydroperoxide	279-283	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	75-81
35435532-14	2022	Mechanistically, we confirmed that the miR-130b-3p regulated the ATG14 and PRKAA1 directly and the knockdown of the ATG14 or PRKAA1 as well as the treatment of autophagy inhibitor blockaded the autophagic flux and reversed the protective effects of miR-130b-3p inhibition in the TBHP-induced human NP cells.	tert-Butylhydroperoxide	279-283	autophagy related 14	Homo sapiens	116-121
35435532-14	2022	Mechanistically, we confirmed that the miR-130b-3p regulated the ATG14 and PRKAA1 directly and the knockdown of the ATG14 or PRKAA1 as well as the treatment of autophagy inhibitor blockaded the autophagic flux and reversed the protective effects of miR-130b-3p inhibition in the TBHP-induced human NP cells.	tert-Butylhydroperoxide	279-283	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	125-131
35526444-8	2022	Layers under tBHP challenge up-regulated mRNA expression of pro-inflammatory cytokine (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)) and nuclear factor NF-kappaB (P(tBHP)<0.05) in jejunum.	tert-Butylhydroperoxide	13-17	interleukin 1, beta	Gallus gallus	87-104
35526444-8	2022	Layers under tBHP challenge up-regulated mRNA expression of pro-inflammatory cytokine (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)) and nuclear factor NF-kappaB (P(tBHP)<0.05) in jejunum.	tert-Butylhydroperoxide	13-17	interleukin 1, beta	Gallus gallus	106-114
35526444-8	2022	Layers under tBHP challenge up-regulated mRNA expression of pro-inflammatory cytokine (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)) and nuclear factor NF-kappaB (P(tBHP)<0.05) in jejunum.	tert-Butylhydroperoxide	13-17	interleukin 6	Gallus gallus	117-130
35526444-8	2022	Layers under tBHP challenge up-regulated mRNA expression of pro-inflammatory cytokine (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)) and nuclear factor NF-kappaB (P(tBHP)<0.05) in jejunum.	tert-Butylhydroperoxide	13-17	interleukin 6	Gallus gallus	132-136
35526444-8	2022	Layers under tBHP challenge up-regulated mRNA expression of pro-inflammatory cytokine (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)) and nuclear factor NF-kappaB (P(tBHP)<0.05) in jejunum.	tert-Butylhydroperoxide	13-17	lipopolysaccharide induced TNF factor	Gallus gallus	143-170
35526444-8	2022	Layers under tBHP challenge up-regulated mRNA expression of pro-inflammatory cytokine (interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha)) and nuclear factor NF-kappaB (P(tBHP)<0.05) in jejunum.	tert-Butylhydroperoxide	13-17	lipopolysaccharide induced TNF factor	Gallus gallus	172-181
35367421-0	2022	A transcriptomics and molecular biology based investigation reveals the protective effect and mechanism of carnosol on t-BHP induced HRMECs via Nrf2 signaling pathway.	tert-Butylhydroperoxide	119-124	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
35231441-15	2022	CESC-exomiR-125-5p inhibited TBHP-NPCs apoptosis by inhibiting SUV39H1, bax, MMP13, and p62 expression, while increased bcl2, ACAN, LC3-II/I expression, and the fluorescence intensity of GFP-LC3, thereby alleviating rat IDD.	tert-Butylhydroperoxide	29-33	SUV39H1 histone lysine methyltransferase	Rattus norvegicus	63-70
35231441-15	2022	CESC-exomiR-125-5p inhibited TBHP-NPCs apoptosis by inhibiting SUV39H1, bax, MMP13, and p62 expression, while increased bcl2, ACAN, LC3-II/I expression, and the fluorescence intensity of GFP-LC3, thereby alleviating rat IDD.	tert-Butylhydroperoxide	29-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	72-75
35231441-15	2022	CESC-exomiR-125-5p inhibited TBHP-NPCs apoptosis by inhibiting SUV39H1, bax, MMP13, and p62 expression, while increased bcl2, ACAN, LC3-II/I expression, and the fluorescence intensity of GFP-LC3, thereby alleviating rat IDD.	tert-Butylhydroperoxide	29-33	matrix metallopeptidase 13	Rattus norvegicus	77-82
35231441-15	2022	CESC-exomiR-125-5p inhibited TBHP-NPCs apoptosis by inhibiting SUV39H1, bax, MMP13, and p62 expression, while increased bcl2, ACAN, LC3-II/I expression, and the fluorescence intensity of GFP-LC3, thereby alleviating rat IDD.	tert-Butylhydroperoxide	29-33	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	88-91
35231441-15	2022	CESC-exomiR-125-5p inhibited TBHP-NPCs apoptosis by inhibiting SUV39H1, bax, MMP13, and p62 expression, while increased bcl2, ACAN, LC3-II/I expression, and the fluorescence intensity of GFP-LC3, thereby alleviating rat IDD.	tert-Butylhydroperoxide	29-33	BCL2, apoptosis regulator	Rattus norvegicus	120-124
35231441-15	2022	CESC-exomiR-125-5p inhibited TBHP-NPCs apoptosis by inhibiting SUV39H1, bax, MMP13, and p62 expression, while increased bcl2, ACAN, LC3-II/I expression, and the fluorescence intensity of GFP-LC3, thereby alleviating rat IDD.	tert-Butylhydroperoxide	29-33	aggrecan	Rattus norvegicus	126-130
35231441-15	2022	CESC-exomiR-125-5p inhibited TBHP-NPCs apoptosis by inhibiting SUV39H1, bax, MMP13, and p62 expression, while increased bcl2, ACAN, LC3-II/I expression, and the fluorescence intensity of GFP-LC3, thereby alleviating rat IDD.	tert-Butylhydroperoxide	29-33	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	132-140
35464773-5	2022	Tertbutyl hydroperoxide can inhibit the expression of PREP by activating the PI3K/AKT signaling pathway at low concentrations in NP cells.	tert-Butylhydroperoxide	0-23	prolyl endopeptidase	Homo sapiens	54-58
35480873-0	2022	Silencing ATF3 Might Delay TBHP-Induced Intervertebral Disc Degeneration by Repressing NPC Ferroptosis, Apoptosis, and ECM Degradation.	tert-Butylhydroperoxide	27-31	activating transcription factor 3	Homo sapiens	10-14
35480873-5	2022	The loss- and gain-of-function experiments demonstrated that ATF3 positively regulated tert-butyl hydroperoxide- (TBHP-) induced nucleus pulposus cell (NPC) FAoptosis, ROS production, inflammatory response, and extracellular matrix (ECM) degradation.	tert-Butylhydroperoxide	87-111	activating transcription factor 3	Homo sapiens	61-65
35480873-5	2022	The loss- and gain-of-function experiments demonstrated that ATF3 positively regulated tert-butyl hydroperoxide- (TBHP-) induced nucleus pulposus cell (NPC) FAoptosis, ROS production, inflammatory response, and extracellular matrix (ECM) degradation.	tert-Butylhydroperoxide	114-118	activating transcription factor 3	Homo sapiens	61-65
35464773-5	2022	Tertbutyl hydroperoxide can inhibit the expression of PREP by activating the PI3K/AKT signaling pathway at low concentrations in NP cells.	tert-Butylhydroperoxide	0-23	AKT serine/threonine kinase 1	Homo sapiens	82-85
35450408-0	2022	Selenium Attenuates TBHP-Induced Apoptosis of Nucleus Pulposus Cells by Suppressing Mitochondrial Fission through Activating Nuclear Factor Erythroid 2-Related Factor 2.	tert-Butylhydroperoxide	20-24	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-168
35450408-12	2022	Taken together, our results demonstrated that Se suppressed TBHP-induced oxidative stress and mitochondrial fission by activating the Nrf2 pathway, thereby inhibiting the apoptosis of NPCs and ameliorating IDD.	tert-Butylhydroperoxide	60-64	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
35424560-0	2022	A multi pathway coupled domino strategy: I2/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization.	tert-Butylhydroperoxide	44-48	Sp3 transcription factor	Homo sapiens	106-109
35184666-10	2022	LINC00917 expression was enhanced in TBHP-treated nucleus pulposus cells (NPCs).	tert-Butylhydroperoxide	37-41	long intergenic non-protein coding RNA 917	Homo sapiens	0-9
35424560-0	2022	A multi pathway coupled domino strategy: I2/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization.	tert-Butylhydroperoxide	44-48	Sp2 transcription factor	Homo sapiens	111-114
35163585-15	2022	TBHp treatment increased HER2 expression, whereas shHNMT disrupted the Nuclear factor erythroid 2-related factor 2 (Nrf2)/ hemeoxygenase-1 (HO-1)/HER2 axis and increased reactive oxygen species accumulation in NSCLC cells.	tert-Butylhydroperoxide	0-4	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-29
35109761-7	2022	Further, TET enhanced autophagy in NP cells by amplifying the LC3 II/LC3 I/ratio and reducing p62 expression, which attenuated oxidative stress, apoptosis, and ECM degradation in TBHP-treated NP cells.	tert-Butylhydroperoxide	179-183	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	62-74
35069863-10	2022	Following TBHP treatment, the level of ROS increased significantly, and the concentrations of SOD, CAT and GSH-Px were decreased.	tert-Butylhydroperoxide	10-14	superoxide dismutase 1	Homo sapiens	94-97
35069863-10	2022	Following TBHP treatment, the level of ROS increased significantly, and the concentrations of SOD, CAT and GSH-Px were decreased.	tert-Butylhydroperoxide	10-14	catalase	Homo sapiens	99-102
35098839-5	2022	Oxidative stress associated with tert-butyl hydroperoxide (t-BHP) exposure results in the degradation of L-Opa1 and impairs the balance of L-Opa1/S-Opa1.	tert-Butylhydroperoxide	33-57	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	107-111
35098839-5	2022	Oxidative stress associated with tert-butyl hydroperoxide (t-BHP) exposure results in the degradation of L-Opa1 and impairs the balance of L-Opa1/S-Opa1.	tert-Butylhydroperoxide	59-64	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	107-111
35159424-5	2022	Pretreatment with flavonoids-rich PCR-C samples (particularly PCR-C10) considerably reversed t-BHP-induced oxidative damage in HepG2 cells by improving cell viability, increasing SOD activity and GSH levels and reducing the overproduction of ROS and MDA.	tert-Butylhydroperoxide	93-98	homeobox C10	Homo sapiens	66-69
35096819-6	2021	Mechanistically, we found that TBHP may induce autophagosome and lysosome fusion interruption and lysosomal dysfunction, while apigenin alleviates these phenomena by promoting the nuclear translocation of TFEB via the AMPK/mTOR signaling pathway.	tert-Butylhydroperoxide	31-35	transcription factor EB	Rattus norvegicus	205-209
35096819-6	2021	Mechanistically, we found that TBHP may induce autophagosome and lysosome fusion interruption and lysosomal dysfunction, while apigenin alleviates these phenomena by promoting the nuclear translocation of TFEB via the AMPK/mTOR signaling pathway.	tert-Butylhydroperoxide	31-35	mechanistic target of rapamycin kinase	Rattus norvegicus	223-227
2930785-4	1989	Glyceraldehyde-3-phosphate dehydrogenase was strongly inhibited by tBHP via a direct reaction of the hydroperoxide with an essential sulfhydryl group in the enzyme molecule.	tert-Butylhydroperoxide	67-71	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	0-40
35204081-4	2022	Here, using wild-type and iPLA2gamma-KO mice, we demonstrate the ability of tert-butylhydroperoxide (TBHP) to activate iPLA2gamma in isolated brain mitochondria, with consequent liberation of FAs and lysophospholipids.	tert-Butylhydroperoxide	76-99	patatin-like phospholipase domain containing 8	Mus musculus	26-36
35204081-4	2022	Here, using wild-type and iPLA2gamma-KO mice, we demonstrate the ability of tert-butylhydroperoxide (TBHP) to activate iPLA2gamma in isolated brain mitochondria, with consequent liberation of FAs and lysophospholipids.	tert-Butylhydroperoxide	76-99	patatin-like phospholipase domain containing 8	Mus musculus	119-129
35204081-4	2022	Here, using wild-type and iPLA2gamma-KO mice, we demonstrate the ability of tert-butylhydroperoxide (TBHP) to activate iPLA2gamma in isolated brain mitochondria, with consequent liberation of FAs and lysophospholipids.	tert-Butylhydroperoxide	101-105	patatin-like phospholipase domain containing 8	Mus musculus	26-36
35204081-4	2022	Here, using wild-type and iPLA2gamma-KO mice, we demonstrate the ability of tert-butylhydroperoxide (TBHP) to activate iPLA2gamma in isolated brain mitochondria, with consequent liberation of FAs and lysophospholipids.	tert-Butylhydroperoxide	101-105	patatin-like phospholipase domain containing 8	Mus musculus	119-129
35204081-6	2022	Employing detailed lipidomic analysis, we also demonstrate a typical cleavage pattern for TBHP-activated iPLA2gamma, reflecting cleavage of glycerophospholipids from both sn-1 and sn-2 positions releasing saturated FAs, monoenoic FAs, and predominant polyunsaturated FAs.	tert-Butylhydroperoxide	90-94	patatin-like phospholipase domain containing 8	Mus musculus	105-115
2783125-7	1989	[3H]Phorbol-12,13-dibutyrate-binding studies showed that membrane association of PKC is markedly increased in hepatocytes after exposure to H2O2/Cu2+ or t-butyl hydroperoxide.	tert-Butylhydroperoxide	153-174	proline rich transmembrane protein 2	Homo sapiens	81-84
2528325-8	1989	The Na+ + K+-stimulated Mg2+ ATPase, like the Ca2+ + Mg2+-ATPase, was sensitive to membrane oxidation but the activities of Mg2+-ATPase and acetylcholinesterase were less inhibited by tert-butyl hydroperoxide.	tert-Butylhydroperoxide	184-208	acetylcholinesterase (Cartwright blood group)	Homo sapiens	140-160
2917978-0	1989	Effect of t-butyl-hydroperoxide on bradykinin-stimulated changes in cytosolic calcium in vascular endothelial cells.	tert-Butylhydroperoxide	10-31	kininogen 1	Homo sapiens	35-45
2499570-1	1989	The organic peroxide tert-butyl hydroperoxide (t-bu-OOH) induces pulmonary vasoconstriction by stimulating production of thromboxane in the rabbit lung, possibly by activating phospholipase A2.	tert-Butylhydroperoxide	21-45	phospholipase A2	Oryctolagus cuniculus	176-192
2920033-0	1989	The role of phospholipase A2 in microsomal lipid peroxidation induced with t-butyl hydroperoxide.	tert-Butylhydroperoxide	75-96	phospholipase A2 group IB	Rattus norvegicus	12-28
2920033-1	1989	The role of phospholipase A2 (PlA2) in lipid peroxidation induced with t-butyl hydroperoxide was examined in rat liver microsomes.	tert-Butylhydroperoxide	71-92	phospholipase A2 group IB	Rattus norvegicus	12-28
2920033-1	1989	The role of phospholipase A2 (PlA2) in lipid peroxidation induced with t-butyl hydroperoxide was examined in rat liver microsomes.	tert-Butylhydroperoxide	71-92	phospholipase A2 group IB	Rattus norvegicus	30-34
2920033-2	1989	Exposure of microsomes to t-butyl hydroperoxide was associated with activation of endogenous PlA2.	tert-Butylhydroperoxide	26-47	phospholipase A2 group IB	Rattus norvegicus	93-97
3188034-6	1988	Similarly, toxic concentrations of t-BH also caused a sustained increase in cytosolic Ca2+.	tert-Butylhydroperoxide	35-39	carbonic anhydrase 2	Rattus norvegicus	86-89
3188034-7	1988	The iron chelator, desferrioxamine, and dithiothreitol (DTT), which protected the cells from t-BH toxicity, also prevented the sustained elevation of cytosolic Ca2+.	tert-Butylhydroperoxide	93-97	carbonic anhydrase 2	Rattus norvegicus	160-163
3394154-2	1988	The cytotoxicity of t-BHP was enhanced with increasing duration of the pretreatment with L-buthionine-SR-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, and was correlated with the decrease of cell glutathione, indicating that glutathione constitutes a cellular defense against toxicity by t-BHP.	tert-Butylhydroperoxide	20-25	glutamate-cysteine ligase catalytic subunit	Homo sapiens	149-182
2917978-5	1989	Experiments conducted with cells in a Ca2+-free buffer indicated that t-butyl-hydroperoxide inhibited bradykinin-stimulated Ca2+ influx from the extracellular space and had little effect on agonist-induced release of Ca2+ from internal stores.	tert-Butylhydroperoxide	70-91	kininogen 1	Homo sapiens	102-112