PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
14711460-6	2004	By the method of propidium iodide staining for detection of apoptosis, incubation of the cells with 0.2 mg/mL vit.	Propidium	17-33	vitrin	Homo sapiens	110-113
15033705-3	2003	Using flow cytometry and Annexin V and propidium iodide as markers for apoptosis and necrosis, respectively, SP-D-deficient mice were found to have a 5- to 10-fold increase in the number of apoptotic and necrotic alveolar macrophages in the lungs.	Propidium	39-55	surfactant associated protein D	Mus musculus	109-113
15033737-2	2003	Exposure of T cells to NAD, the substrate for ART2-catalyzed ADP-ribosylation, induces exposure of phosphatidylserine, uptake of propidium iodide, and fragmentation of DNA.	Propidium	129-145	ADP-ribosyltransferase 1	Homo sapiens	46-50
14633857-6	2003	Flow cytometry analysis of annexin-V/propidium iodide-stained cells revealed that PlGF and PlGF/VEGF heterodimer inhibited apoptosis in serum-deprived endothelial cells.	Propidium	37-53	placental growth factor	Homo sapiens	82-86
14633857-6	2003	Flow cytometry analysis of annexin-V/propidium iodide-stained cells revealed that PlGF and PlGF/VEGF heterodimer inhibited apoptosis in serum-deprived endothelial cells.	Propidium	37-53	placental growth factor	Homo sapiens	91-95
14633857-6	2003	Flow cytometry analysis of annexin-V/propidium iodide-stained cells revealed that PlGF and PlGF/VEGF heterodimer inhibited apoptosis in serum-deprived endothelial cells.	Propidium	37-53	vascular endothelial growth factor A	Homo sapiens	96-100
14612980-3	2003	Our results demonstrated that TSP-1 induced apoptosis in CD36 positive cell lines CHRF-288-11, Meg-01 and HL-60, but not CD36 negative K562, at a dose-dependent manner as demonstrated by DNA ladder formation, Annexin V and propidium iodide (PI) stainings.	Propidium	223-239	thrombospondin 1	Homo sapiens	30-35
12952946-5	2003	In these cells, long term treatment with BEL (up to 24 h) results in increased annexin-V binding to the cell surface and nuclear DNA damage, as detected by staining with both DAPI and propidium iodide.	Propidium	184-200	annexin A5	Homo sapiens	79-88
14656068-10	2003	Detection of necrotic and apoptotic neuronal cell death by propidium iodide and an FITC-conjugated Annexin V antibody showed that iNOS inhibition could significantly retard neuronal cell death rostral and caudal to the injury site.	Propidium	59-75	nitric oxide synthase 2	Rattus norvegicus	130-134
12939230-4	2003	METHODS AND RESULTS: Nuclear staining with Hoechst 33258 or propidium iodine showed an increase in apoptotic cells with activation of caspase-3 in VSMCs infected with adenovirus expressing the dominant-negative form of CREB (AdCREBM1).	Propidium	60-76	caspase 3	Rattus norvegicus	134-143
12909277-5	2003	The SNL extract-mediated suppression of cell growth was verified to be apoptotic, based on the appearance of DNA laddering, increase in DNA fragmentation, and low fluorescence intensity in nuclei after propidium iodide staining of the cells.	Propidium	202-218	fascin actin-bundling protein 1	Homo sapiens	4-7
14563321-3	2003	ART2-catalyzed ADP-ribosylation activates the cytolytic P2X7 purinoceptor, causing calcium flux, pore formation, phosphatidylserine exposure, shedding of CD62L, cell shrinkage, and propidium iodide uptake.	Propidium	181-197	ADP-ribosyltransferase 1	Homo sapiens	0-4
14563321-3	2003	ART2-catalyzed ADP-ribosylation activates the cytolytic P2X7 purinoceptor, causing calcium flux, pore formation, phosphatidylserine exposure, shedding of CD62L, cell shrinkage, and propidium iodide uptake.	Propidium	181-197	purinergic receptor P2X 7	Homo sapiens	56-60
14499003-10	2003	IGF-1 also increased the number of Annexin V-free and propidium iodine-free blastocysts in culture (86.8% vs. 75.9% respectively).	Propidium	54-70	insulin-like growth factor 1	Mus musculus	0-5
12742082-7	2003	The increased cell death, assessed by propidium iodide (PI) uptake, occurred not only among the most susceptible CA1 pyramidal cells, but also in CA3 and fascia dentata.	Propidium	38-54	carbonic anhydrase 1	Rattus norvegicus	113-116
12811515-6	2003	Subsequent studies examined whether the TRAIL/Apo-2L-induced killing of DU-145 cells was augmented in the presence of the chemotherapeutic molecules, as measured by annexin V-FITC/propidium iodide staining.	Propidium	180-196	TNF superfamily member 10	Homo sapiens	40-45
12811515-6	2003	Subsequent studies examined whether the TRAIL/Apo-2L-induced killing of DU-145 cells was augmented in the presence of the chemotherapeutic molecules, as measured by annexin V-FITC/propidium iodide staining.	Propidium	180-196	TNF superfamily member 10	Homo sapiens	46-52
14500366-5	2003	Initially we demonstrated that transient expression of RASSF1A into the NSCLC cell line A549 induced G(1) cell cycle arrest, as measured by propidium iodide staining.	Propidium	140-156	Ras association domain family member 1	Homo sapiens	55-62
12742082-7	2003	The increased cell death, assessed by propidium iodide (PI) uptake, occurred not only among the most susceptible CA1 pyramidal cells, but also in CA3 and fascia dentata.	Propidium	38-54	carbonic anhydrase 3	Rattus norvegicus	146-149
12771152-4	2003	We found that 100 ng/ml TGF-alpha attenuated neuronal cell death induced by a 30-min exposure to 35 microM N-methyl-D-aspartic acid (NMDA) (as it reduced lactate dehydrogenase release, propidium iodide staining, and caspase-3 activation) and decreased the elevation of intracellular Ca2+ elicited by NMDA.	Propidium	185-201	transforming growth factor alpha	Rattus norvegicus	24-33
12740370-3	2003	Ets-1 inhibits apoptosis in vascular smooth muscle cells as determined by both fluorescein isothiocyanate-linked annexin V/propidium iodide staining of cells and fluorescence-activated cell sorting analysis and quantitative cytoplasmic histone-associated internucleosomal DNA fragmentation.	Propidium	123-139	ETS proto-oncogene 1, transcription factor	Homo sapiens	0-5
12855674-5	2003	UCP2 overexpression significantly suppressed markers of cell death, including TUNEL positivity, phosphatidylserine exposure, propidium iodide uptake, and caspase-3 cleavage.	Propidium	125-141	uncoupling protein 2	Homo sapiens	0-4
12874246-4	2003	Incubation with TRAIL for 15 h causes approximately 30% of cultured EC to die, as assessed by propidium iodide uptake.	Propidium	94-110	TNF superfamily member 10	Homo sapiens	16-21
21189587-3	2003	Propidium iodide (PI) assay was used to observe the neuronal injury in CA1 and dentate gyrus (DG).	Propidium	0-16	carbonic anhydrase 1	Rattus norvegicus	71-74
12843957-5	2003	In order to assess the health hazard of active recovery of these resting cells, we studied biofilms with two fluorochromes: a fluorescein diacetate derivative, CDF, which detects esterase activity and gives a green fluorescence to cells, and propidium iodide, IP, which enters cells with injured membranes and gives a red fluorescence to nucleic acids.	Propidium	242-258	LIF interleukin 6 family cytokine	Homo sapiens	160-163
12761352-10	2003	Cells expressing human P2X5 receptors also rapidly accumulated the propidium dye YO-PRO-1 in response to ATP.	Propidium	67-76	purinergic receptor P2X 5	Homo sapiens	23-27
12810350-6	2003	Annexin V-fluorescein isothiocyanate (FITC)-propidium iodide (PI) apoptosis flow cytometric assay showed that early apoptotic CD4(+) T cells (annexin V-FITC(+)PI(-)), but not late apoptotic CD4(+) T cells (annexin V-FITC(+)PI(+)), increased in the inflamed skin of mice with CH.	Propidium	44-60	annexin A5	Mus musculus	0-9
12810350-6	2003	Annexin V-fluorescein isothiocyanate (FITC)-propidium iodide (PI) apoptosis flow cytometric assay showed that early apoptotic CD4(+) T cells (annexin V-FITC(+)PI(-)), but not late apoptotic CD4(+) T cells (annexin V-FITC(+)PI(+)), increased in the inflamed skin of mice with CH.	Propidium	44-60	CD4 antigen	Mus musculus	126-129
12810350-6	2003	Annexin V-fluorescein isothiocyanate (FITC)-propidium iodide (PI) apoptosis flow cytometric assay showed that early apoptotic CD4(+) T cells (annexin V-FITC(+)PI(-)), but not late apoptotic CD4(+) T cells (annexin V-FITC(+)PI(+)), increased in the inflamed skin of mice with CH.	Propidium	44-60	annexin A5	Mus musculus	142-151
12862317-5	2003	Using propidium iodide staining and green fluorescent protein (GFP) tag technologies, VCY and VCX-8r proteins were mainly localized in the nucleoli of COS7 cells.	Propidium	6-22	variable charge Y-linked	Homo sapiens	86-89
12761352-10	2003	Cells expressing human P2X5 receptors also rapidly accumulated the propidium dye YO-PRO-1 in response to ATP.	Propidium	67-76	lamin A/C	Homo sapiens	84-89
12668727-7	2003	Fourth, by contrast, three CaM antagonists (W7, ophiobolin A and calmidazolium) significantly inhibited protein tyrosine phosphorylation of sperm components (42, 56, 66, 82 and 95 kDa) and adversely affected their motility without altering viability as assessed by propidium iodine staining.	Propidium	265-281	calmodulin 2	Mus musculus	27-30
12697681-6	2003	In three different assays for apoptosis, including trypan blue exclusion, changes in nuclear morphology, and fluorescence-activated cell sorting staining for annexin V/propidium iodide, CD40L significantly inhibited apoptosis of MLO-Y4 cells induced by dexamethasone, TNF alpha, or etoposide.	Propidium	168-184	CD40 ligand	Mus musculus	186-191
12670879-5	2003	The number of necrotic cells, evaluated by propidium iodide uptake, was reduced when cells from the Grp94-overexpressing H9c2 clone were exposed to conditions simulating ischemia.	Propidium	43-59	heat shock protein 90 beta family member 1	Rattus norvegicus	100-105
12670879-7	2003	A lower percentage of propidium-iodide positive/GFP-fluorescent myocytes co-expressing exogenous Grp94, with respect to myocytes expressing GFP alone, was observed after exposure to either A23187 (6.6% vs. 14.0%, respectively) or simulated ischemia (8.5% vs. 17.7%, respectively).	Propidium	22-38	heat shock protein 90 beta family member 1	Rattus norvegicus	97-102
12802914-4	2003	After 4 days of incubation viable mononuclear myeloid cells were identified by the exclusion of propidium iodide in CD13 or CD33 positive cells.	Propidium	96-112	alanyl aminopeptidase, membrane	Homo sapiens	116-120
12578750-4	2003	Modulation of apoptosis induced in U937 or Jurkat cells by CD95 (Fas-ligand) or TNF-alpha was measured using flow cytometry using the 7-AAD and annexin/propidium iodide methods.	Propidium	152-168	Fas cell surface death receptor	Homo sapiens	59-63
12622373-4	2003	A CE-LIF technique for determining the viability of boar sperm was developed using the fluorescent stains SYBER-14 and propidium iodide.	Propidium	119-135	LIF interleukin 6 family cytokine	Homo sapiens	5-8
12604406-5	2003	The extent of apoptosis following exposure to TRAIL was measured by annexin-V/propidium iodide dual staining.	Propidium	78-94	TNF superfamily member 10	Homo sapiens	46-51
12565696-3	2003	In all postnatal ages investigated (4, 7, 14, 20, 27, 40 days-old and adult rats), AChE effect on binding was concentration-dependent and blocked by propidium, BW 284c51, diisopropylfluorophosphonate and eserine, therefore requiring indemnity of both peripheral and active sites of the enzyme.	Propidium	149-158	acetylcholinesterase	Rattus norvegicus	83-87
12578750-4	2003	Modulation of apoptosis induced in U937 or Jurkat cells by CD95 (Fas-ligand) or TNF-alpha was measured using flow cytometry using the 7-AAD and annexin/propidium iodide methods.	Propidium	152-168	tumor necrosis factor	Homo sapiens	80-89
14706926-6	2003	Flow cytometric analysis of annexin V and propidium iodide incorporation showed that GM-CSF up-regulated apoptotic cell death of SaOS-2 cells after 14 days of culture in contrast to okadaic acid, which stimulated SaOS-2 apoptosis only during the early period of culture.	Propidium	42-58	colony stimulating factor 2	Homo sapiens	85-91
12505979-3	2003	A novel crystal form of mouse AChE, combined with spectrophotometric analyses of the crystals, enabled us to solve unique structures of AChE with a free peripheral site, and as three complexes with peripheral site inhibitors: the phenylphenanthridinium ligands, decidium and propidium, and the pyrogallol ligand, gallamine, at 2.20-2.35 A resolution.	Propidium	275-284	acetylcholinesterase	Mus musculus	30-34
12505979-3	2003	A novel crystal form of mouse AChE, combined with spectrophotometric analyses of the crystals, enabled us to solve unique structures of AChE with a free peripheral site, and as three complexes with peripheral site inhibitors: the phenylphenanthridinium ligands, decidium and propidium, and the pyrogallol ligand, gallamine, at 2.20-2.35 A resolution.	Propidium	275-284	acetylcholinesterase	Mus musculus	136-140
12604370-12	2003	Role of TGF-beta on post-activated human T cells was further confirmed by staining apoptotic nuclei with propidium iodide, which detects late events of apoptosis, and by DNA fragmentation determined using TUNEL assay.	Propidium	105-121	transforming growth factor beta 1	Homo sapiens	8-16
12483365-4	2002	In addition, the ploidy of propidium iodide stained CD61 positive cells were detected by flow cytometry.	Propidium	27-43	integrin subunit beta 3	Homo sapiens	52-56
12500088-3	2003	In ischemic CSF, OGD induced a selective and delayed cell death in the CA1 region, as assessed by propidium iodide uptake.	Propidium	98-114	carbonic anhydrase 1	Mus musculus	71-74
12444058-8	2002	When embryos were assessed for apoptosis and cell number by confocal microscopy after TUNEL and propidium iodine staining, it was found that blastocysts cultured in GM-CSF contained 50% fewer apoptotic nuclei and 30% more viable inner cell mass cells.	Propidium	96-112	colony stimulating factor 2	Homo sapiens	165-171
12372614-3	2002	Plasmid-mediated overexpression of Ser-156, Gly-167, Tyr-168 and Ser-181 SFD mutant TIMP-3 decreased RPE viability to 22+/-8, 20+/-6, 32+/-5, 30+/-12% (SFD mutants all P<0.01 versus wild-type 50+/-8%) and similarly increased propidium iodide staining and in situ end labelling.	Propidium	228-244	TIMP metallopeptidase inhibitor 3	Homo sapiens	84-90
12390973-4	2002	TRAIL induces ahOL apoptosis--as characterized by Annexin V staining prior to propidium iodide cell uptake--under conditions of protein synthesis inhibition.	Propidium	78-94	TNF superfamily member 10	Homo sapiens	0-5
12356842-4	2002	Viability of ECs from piglets and humans in response to C-PAF (a stable PAF analogue) was determined by the reduction of the tetrazolium salt 3-(4,5-dimethyl thiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT) by viable cells, incorporation of propidium iodide (PI), TUNEL assay, and release of lactate dehydrogenase.	Propidium	244-260	PCNA clamp associated factor	Rattus norvegicus	58-61
12383198-8	2002	The percentage of annexin-positive and propidium iodide (PI)-negative apoptotic cells was significantly higher in SAMP1 than in C3H/He at 96 hr of culture.	Propidium	39-55	transmembrane protein 201	Mus musculus	114-119
12165798-4	2002	With regard to annexin V and propidium iodide, approximately 40 and 5% of the human peripheral T cells showed positivity against annexin V and propidium iodide at that time, respectively.	Propidium	29-45	annexin A5	Homo sapiens	129-138
12234263-7	2002	Coincubation with anti-CD69 or anti-CD95 monoclonal antibody (MoAb) induced apoptosis, as revealed by propidium iodide incorporation, membrane blebbing and nuclear fragmentation.	Propidium	102-118	CD69 molecule	Homo sapiens	23-27
12234263-7	2002	Coincubation with anti-CD69 or anti-CD95 monoclonal antibody (MoAb) induced apoptosis, as revealed by propidium iodide incorporation, membrane blebbing and nuclear fragmentation.	Propidium	102-118	Fas cell surface death receptor	Homo sapiens	36-40
12218102-3	2002	We report here that SP-D-deficient mice have a 5- to 10-fold increase in the number of apoptotic and necrotic alveolar macrophages, as defined by annexin V and propidium iodine staining, respectively.	Propidium	160-176	surfactant associated protein D	Mus musculus	20-24
12165798-4	2002	With regard to annexin V and propidium iodide, approximately 40 and 5% of the human peripheral T cells showed positivity against annexin V and propidium iodide at that time, respectively.	Propidium	143-159	annexin A5	Homo sapiens	15-24
12215301-2	2002	METHODS: Apoptosis in XG-7 myeloma cells induced by IL-6 withdrawal was determined by flow cytometry with propidium iodide (PI) nuclear staining.	Propidium	106-122	interleukin 6	Homo sapiens	52-56
12359055-6	2002	p53 overexpression also induced apoptosis and cell cycle arrest, as determined by annexin V and propidium iodide staining.	Propidium	96-112	tumor protein p53	Homo sapiens	0-3
11909861-9	2002	In fibroblast cultures, cells with increased permeability to propidium iodide exhibited approximately 2-fold less filamin A content than impermeable cells.	Propidium	61-77	filamin A	Homo sapiens	114-123
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	Propidium	329-345	presenilin 2	Homo sapiens	45-57
12014425-5	2002	Interferon-gamma production was determined in the supernatant by ELISA and the induction of apoptosis by flow cytometry after propidium iodide staining.	Propidium	126-142	interferon gamma	Homo sapiens	0-16
14660053-4	2002	NK-cell activation in response to IL-12 and IL-18 was investigated by selective flow cytometry using propidium iodide.	Propidium	101-117	interleukin 18	Homo sapiens	44-49
11934900-7	2002	(5) Most of the cells having H-Ras(V12), H-Ras(V12)T35S, or Raf-1 became annexin-V(high)/propidium iodide (PI)(high or low) and terminal deoxynucleotidyl-transferase-mediated dUTP nick-end labeling (TUNEL)(high)/PI(low) after 24 and 72 h incubation, respectively.	Propidium	89-105	immunoglobulin lambda variable 2-8	Homo sapiens	29-38
11934900-7	2002	(5) Most of the cells having H-Ras(V12), H-Ras(V12)T35S, or Raf-1 became annexin-V(high)/propidium iodide (PI)(high or low) and terminal deoxynucleotidyl-transferase-mediated dUTP nick-end labeling (TUNEL)(high)/PI(low) after 24 and 72 h incubation, respectively.	Propidium	89-105	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	60-65
11815665-9	2002	Moreover, Cx45 nonjunctional hemichannels appeared to mediate lucifer yellow (LY) and propidium iodide (PI) dye uptake from the external solution when extracellular Ca(2+) level was reduced.	Propidium	86-102	gap junction protein gamma 1	Homo sapiens	10-14
11896938-10	2002	The later stage of apoptosis of neutrophils treated in vitro with anti-CD95 Ab of patients suffering from DM1 was decreased in comparison with prediabetics and healthy donors (propidium iodide (PI) staining).	Propidium	176-192	Fas cell surface death receptor	Homo sapiens	71-75
11804605-3	2002	HPRT-variants are enumerated on the basis of both DNA synthesis (by use of immunofluorescent detection of incorporated 5-bromo-2-deoxyuridine, BrdU) and total DNA content (by propidium iodide (PI) incorporation) of proliferating cells, i.e. the cells must both be labelled with BrdU and reside in late-S or G2 phase in order to be scored as a HPRT-variant.	Propidium	175-191	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-4
11744336-6	2001	The cytotoxicity of AS, as measured by propidium iodide uptake, was abolished by electron acceptors potassium ferricyanide, TEMPOL, the intracellular calcium chelator BAPTA-AM, and by PARP inhibitors 3-aminobenzamide (3-AB) and PJ-34.	Propidium	39-55	poly (ADP-ribose) polymerase family, member 1	Mus musculus	184-188
11729224-8	2001	Labeling with annexin V-FITC and propidium iodide, followed by flow cytometry, revealed that overexpression of HSP72 was associated with a reduction in the number of apoptotic-lysed cells, a concomitant retardation of apoptosis, and an increase in the number of viable cells.	Propidium	33-49	heat shock protein family A (Hsp70) member 1A	Homo sapiens	111-116
11886524-5	2001	Conversely, propidium iodide staining, PARP cleavage patterns, and random DNA fragmentation revealed a dose-dependent increase in necrosis in PARP(+/+) but not PARP(-/-) cells.	Propidium	12-28	poly (ADP-ribose) polymerase family, member 1	Mus musculus	142-146
11886524-5	2001	Conversely, propidium iodide staining, PARP cleavage patterns, and random DNA fragmentation revealed a dose-dependent increase in necrosis in PARP(+/+) but not PARP(-/-) cells.	Propidium	12-28	poly (ADP-ribose) polymerase family, member 1	Mus musculus	142-146
11904448-3	2002	Here we establish that the overexpression of presenilin 2 (PS2) and its mutated form Asn-141-Ile-PS2 alters the viability of human embryonic kidney (HEK)293 cells as established by combined trypan blue exclusion, sodium 3"-[1-(phenylamino-carbonyl)-3,4-tetrazolium]-bis(4-methoxy-6-nitro)benzene sulfonic acid hydrate assay, and propidium iodide incorporation FACS analyses.	Propidium	329-345	presenilin 2	Homo sapiens	59-62
11681416-7	2001	And the number of the annexin V-/propidium iodide- apoptotic cells in the antisense ODN-treated cells after 3 days of culture was two-fold higher than that in the control.	Propidium	33-49	annexin A5	Homo sapiens	22-31
11640901-4	2001	FBP reduced [Ca2+]i changes in hypoxic hippocampal neurons, regardless of [Ca2+]e, and preserved cellular integrity as measured by trypan blue or propidium iodide exclusion and [ATP].	Propidium	146-162	fructose-bisphosphatase 1	Homo sapiens	0-3
11527959-8	2001	RT-PCR/Southern and Northern blot analysis confirmed the expression patterns of selected genes, and flow cytometry showed increased annexin V/propidium iodide-labeled cells when grown on AGE-Matrigel.	Propidium	142-158	annexin A5	Homo sapiens	132-141
11595380-3	2001	Fluorochromatization with Propidium Iodide (PI) and Annexin V (AnxV) of cells rewarmed for 1 h caused an increase of AnxV-positive cells without PI staining and any observed lactate dehydrogenase leakage.	Propidium	26-42	annexin A5	Rattus norvegicus	117-121
11278357-10	2001	Instead, caspase inhibitors directed IFNgamma/TNFalpha-treated ME-180 cells to undergo necrosis, as demonstrated by Hoechst 33258/propidium iodide staining and electron microscopy.	Propidium	130-146	interferon gamma	Homo sapiens	37-45
11444925-7	2001	However, specific inhibition of NF-kappa B activation by Ad5-I kappa B alpha Delta N (MOI=50) or MG132 (5 microm) increased apoptosis as measured by subG1-assay (H9c2 cells) and annexin V binding/propidium iodide (neonatal cardiomyocytes, FACS-analysis: 7+/-2% to 26+/-5% annexin V positive/PI negative), respectively.	Propidium	196-212	NFKB inhibitor alpha	Rattus norvegicus	61-76
11278357-10	2001	Instead, caspase inhibitors directed IFNgamma/TNFalpha-treated ME-180 cells to undergo necrosis, as demonstrated by Hoechst 33258/propidium iodide staining and electron microscopy.	Propidium	130-146	tumor necrosis factor	Homo sapiens	46-54
11401498-4	2001	Candida albicans treated with PMAP-23 showed higher fluorescence intensity by propidium iodide(PI) staining, which was similar to that of Melittin than untreated cells.	Propidium	78-94	antibacterial peptide PMAP-23	Sus scrofa	30-37
11290771-4	2001	A new mAb to these CD99 epitopes, Ad20, induces programmed cell death of transformed T cells as determined by morphological changes, phosphatidylserine exposure on the cell surface, and uptake of propidium iodide.	Propidium	196-212	CD99 molecule (Xg blood group)	Homo sapiens	19-23
11014349-8	2000	Characteristic features of apoptosis-like incorporation of propidium iodide (PI), such as increased annexin V binding, changes in mitochondrial membrane potential, and induction of DNA breaks (as evidenced by TUNEL techniques), could be induced in lymphoblasts after chlorpromazine treatment.	Propidium	59-75	annexin A5	Homo sapiens	100-109
11220641-4	2001	The apoptosis of hepatocytes under septic condition or hepatocytes treated with PKCalpha antisense was evaluated by gel electrophoresis and/or flow cytometry after Annexin-V-Fluos and propidium iodide staining.	Propidium	184-200	protein kinase C alpha	Homo sapiens	80-88
11053548-9	2000	It cannot be ascertained from the current study whether the putative second binding site is identical to or shares common elements with the well-characterized propidium-specific peripheral binding site of acetylcholinesterase.	Propidium	159-168	acetylcholinesterase	Mus musculus	205-225
11069054-2	2000	Here, we provide evidence that occupancy of LAIR-1 on human myelomonocytic leukemic cell lines inhibits proliferation and leads to programmed cell death (PCD), evaluated by propidium iodide staining and transmission electron microscopy.	Propidium	173-189	leukocyte associated immunoglobulin like receptor 1	Homo sapiens	44-50
11131641-1	2000	Recombinant canine interleukin-18 (IL-18) induced apoptosis in vitro in a canine cancer cell line derived from canine mammary gland tumor tissue as determined by electrophoretical DNA separation and flow cytometry after propidium iodine staining.	Propidium	220-236	interleukin 18	Canis lupus familiaris	19-33
11131641-1	2000	Recombinant canine interleukin-18 (IL-18) induced apoptosis in vitro in a canine cancer cell line derived from canine mammary gland tumor tissue as determined by electrophoretical DNA separation and flow cytometry after propidium iodine staining.	Propidium	220-236	interleukin 18	Canis lupus familiaris	35-40
11083624-2	2000	The results revealed that hLF(1-11) was more effective in killing fluconazole-resistant Candida albicans than hLF(21-31) and much more effective than lactoferrin, as determined microbiologically and by propidium iodide (PI) staining.	Propidium	202-218	HLF transcription factor, PAR bZIP family member	Homo sapiens	26-29
11150373-5	2000	Apoptosis after treatment with the NF-kappa B inhibitors gliotoxin, MG132, BAY 11-7082, and BAY 11-7085 was quantitatively measured in the CTCL cell lines HuT-78 and HH by propidium iodide (PI)/cell cycle analysis for detection of a hypodiploid (sub-G(0)) population and by determination of increased Annexin V/7-amino-actinomycin D (7-AAD) expression.	Propidium	172-188	nuclear factor kappa B subunit 1	Homo sapiens	35-45
11428648-5	2000	The cell populations of HEK that showed enhanced C1q binding also demonstrated an intermediate uptake of propidium iodide that was greater than in viable unexposed cells but less than in dead cells.	Propidium	105-121	complement C1q A chain	Homo sapiens	49-52
11054088-4	2000	However, HSP72 expression in HUVECs increased apoptosis induced by TNF-alpha/CHX, LPS and VT measured by flow cytometric analysis of propidium iodide (PI)-stained permeabilized cells.	Propidium	133-149	heat shock protein family A (Hsp70) member 1A	Homo sapiens	9-14
10994850-3	2000	Activation of caspase-3 and cell death was examined in situ by high-resolution confocal microscopy with anti-active caspase-3 antibody and propidium iodide and by biochemical analysis.	Propidium	139-155	caspase 3	Rattus norvegicus	14-23
11275256-9	2000	They were also partially inhibited by the AChE-specific inhibitors, BW284c51 and propidium.	Propidium	81-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	42-46
10931118-6	2000	To evaluate the proliferating activity of NGF on the human cultured mast cells, flow cytometric analysis with propidium iodide staining was applied.	Propidium	110-126	nerve growth factor	Homo sapiens	42-45
10839919-5	2000	A specific antibody against the p65 subunit of NF-kappaB was used and detected by fluoresceine-isothiocyanate-labeled anti-immunoglobulin G. Nuclei were stained with propidium iodide.	Propidium	166-182	RELA proto-oncogene, NF-kB subunit	Homo sapiens	32-56
10648652-8	2000	In contrast, huprine X did form a ternary complex with propidium and AChE, although its affinity for the free enzyme was found to be 17 times its affinity for the propidium-AChE complex.	Propidium	163-172	acetylcholinesterase (Cartwright blood group)	Homo sapiens	173-177
10762371-6	2000	Measurement of cell death, performed with propidium iodide 48 h after a 30-min exposure to bicuculline, revealed most prominent degeneration of pyramidal neurons in the CA3 pyramidal layer.	Propidium	42-58	carbonic anhydrase 3	Homo sapiens	169-172
10694198-3	2000	When PTH(1 - 34) at a lower concentration (1 nM) was added to the culture medium and its toxic effects examined using a propidium iodide intercalation method, significant toxicity was seen 3 days after exposure and increased with time.	Propidium	120-136	parathyroid hormone	Rattus norvegicus	5-8
11920190-10	2000	Consistent with an increased platelet production, platelets from uPAR-/- mice had a higher RNA content, as seen by Propidium Iodide (PI) labeling and FACS analysis.	Propidium	115-131	plasminogen activator, urokinase receptor	Mus musculus	65-69
11093032-7	2000	However, osmotic cell shrinkage almost abolished CD95-induced DNA fragmentation (as revealed by propidium iodide staining) and the activation of a DNase as evidenced from SDS-PAGE gel assay.	Propidium	96-112	Fas cell surface death receptor	Homo sapiens	49-53
10619655-4	1999	The action of AChE was not affected by edrophonium and tacrine both active site inhibitors, but it was abolished by propidium and gallamine, two peripheral anionic binding site (PAS) ligands.	Propidium	116-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-18
10661886-2	2000	Methanol extract of Orostachys japonicus A. Berger (Crassulaceae), a traditional oriental medical herb, was shown to have a protective effect on H2O2-induced apoptosis in GT1-1 mouse hypothalamic neuronal cell line which was detected by flow cytometry after propidium iodide staining.	Propidium	258-274	retinoic acid induced 1	Mus musculus	171-176
10617114-10	2000	Double labeling with propidium iodide to detect chromatin condensation indicated that affinity-labeled caspase-3-like proteases were specifically expressed in apoptotic cells.	Propidium	21-37	caspase 3	Homo sapiens	103-112
10204537-3	1999	We now show that, during longer ATP application (10-60 s), the channel also becomes permeable to much larger cations such as N-methyl-D-glucamine and the propidium analog YO-PRO-1.	Propidium	154-163	lamin A/C	Homo sapiens	174-179
10480436-4	1999	Thus, incubation with FasL for 48 hours reduced cell death from 46 to 29% compared to cells cultured in medium alone as measured by propidium iodide (PI) incorporation (n = 8, p < 0.02).	Propidium	132-148	Fas ligand	Homo sapiens	22-26
10574656-4	1999	Further, serum vitamin E levels were decreased by 50% in the n-3 PUFA-fed group, whereas higher anti-Fas- and anti-CD3-induced apoptosis (65 and 66%) and necrosis (17 and 25%), compared to the n-6 PUFA-fed group, were found when measured with Annexin V and propidium iodide staining, respectively.	Propidium	257-273	CD3 antigen, epsilon polypeptide	Mus musculus	115-118
10455154-6	1999	Here we report that, although L929 cells underwent DNA fragmentation after exposure to TNF, they retained the morphology of intact nuclei while gaining permeability to propidium iodide, features characteristic of necrosis rather than apoptosis.	Propidium	168-184	tumor necrosis factor	Mus musculus	87-90
10453073-1	1999	Phosphatidylserine (PS) exposure on propidium iodide negative cells using FITC labelled annexin-V has been used to quantify apoptosis in vitro and in vivo.	Propidium	36-52	annexin A5	Homo sapiens	88-97
10371171-3	1999	METHODS: Apoptosis occurring in cocultures of chronically HIV-1 IIIB-infected cells with CD4 target cells expressing the CXCR4 receptor was quantified by terminal deoxinucleotidyl transferase dUTP nick end labeling (TUNEL) or propidium iodide staining followed by fluorescent antibody cell sorting, which allows the evaluation of single-cell killing.	Propidium	226-242	CD4 molecule	Homo sapiens	89-92
10371171-3	1999	METHODS: Apoptosis occurring in cocultures of chronically HIV-1 IIIB-infected cells with CD4 target cells expressing the CXCR4 receptor was quantified by terminal deoxinucleotidyl transferase dUTP nick end labeling (TUNEL) or propidium iodide staining followed by fluorescent antibody cell sorting, which allows the evaluation of single-cell killing.	Propidium	226-242	C-X-C motif chemokine receptor 4	Homo sapiens	121-126
10329459-2	1999	We have observed that the specific acetylcholinesterase peripheral anionic site inhibitors, BW284c51 and propidium iodide, abrogated cell-substrate adhesion in three human neuroblastoma cell lines.	Propidium	105-121	acetylcholinesterase (Cartwright blood group)	Homo sapiens	35-55
10421442-9	1999	The 2nd-order phosphorylation rate constant kOP/K(OP) was decreased 3-fold by a high concentration of propidium and the 1st-order rate constant kOP increased somewhat.	Propidium	102-111	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	44-47
10421442-9	1999	The 2nd-order phosphorylation rate constant kOP/K(OP) was decreased 3-fold by a high concentration of propidium and the 1st-order rate constant kOP increased somewhat.	Propidium	102-111	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	48-53
10421442-9	1999	The 2nd-order phosphorylation rate constant kOP/K(OP) was decreased 3-fold by a high concentration of propidium and the 1st-order rate constant kOP increased somewhat.	Propidium	102-111	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	144-147
10421442-10	1999	In contrast to propidium, when the neurotoxin fasciculin bound to the AChE peripheral site both a steric blockade and a conformational change in the acylation site appeared to occur.	Propidium	15-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
10221754-4	1999	This increase is completely blocked by the specific AChE inhibitors propidium, physostigmine, DFP and BW 284C51.	Propidium	68-77	acetylcholinesterase	Rattus norvegicus	52-56
10344522-2	1999	We assessed accumulation of fluorescence-stained NF-kappaB into propidium iodide-stained nuclei using laser scanning cytometry.	Propidium	64-80	nuclear factor kappa B subunit 1	Homo sapiens	49-58
10085081-7	1999	Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates.	Propidium	28-37	acetylcholinesterase (Cartwright blood group)	Homo sapiens	45-49
10085081-7	1999	Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates.	Propidium	28-37	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	76-79
10085081-7	1999	Binding of the small ligand propidium to the AChE peripheral site decreased kOP/KOP by factors of 2-20 for these organophosphates.	Propidium	28-37	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	80-83
10085081-9	1999	Moreover, the binding of propidium resulted in a clear increase in kOP for EMPC, suggesting that molecular or electronic strain caused by the proximity of propidium to EMPC in the ternary complex may promote phosphorylation.	Propidium	25-34	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	67-70
10085081-9	1999	Moreover, the binding of propidium resulted in a clear increase in kOP for EMPC, suggesting that molecular or electronic strain caused by the proximity of propidium to EMPC in the ternary complex may promote phosphorylation.	Propidium	155-164	serine peptidase inhibitor, Kunitz type 2	Homo sapiens	67-70
10092773-7	1999	The SHP-1C453S-expressing cells also displayed diminished rates of apoptosis as detected by flow cytometric analysis of propidium iodide-stained cells and terminal deoxynucleotidyltransferase-mediated fluorescein-dUTP nick end-labeling assay.	Propidium	120-136	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	4-14
10103097-5	1999	Edrophonium or propidium, other specific inhibitors of AChE, did so to a much lesser extent.	Propidium	15-24	acetylcholinesterase	Rattus norvegicus	55-59
10224465-3	1999	RESULTS: Trypan blue staining, propidium iodide/ CellTrackertrade markGreen staining and incorporation of 14C-leucine assays indicated that MBP damages most cells by 1 h. In contrast, 51Cr and lactic dehydrogenase (LDH) release assays indicated that MBP damages most cells only at 20 h. All five methods indicated that melittin damages nearly all cells by 1 h. To resolve these discrepancies, the procedures were modified.	Propidium	31-47	myelin basic protein	Homo sapiens	140-143
9920290-8	1999	A previous study by single-color (propidium) flow cytometry demonstrated that A(II) blocks MDA-MB-231 cells in G2/M of the cell cycle.	Propidium	34-43	NLR family pyrin domain containing 3	Homo sapiens	78-83
10210284-3	1999	Following incubation of the cells with Mic-1 (10-100 nM) or Mic-3 (10-100 nM), internucleosomal DNA fragmentation in apoptotic cells was detected by agarose gel electrophoresis and the diphenylamine (DPA) assay; the presence of hypodiploid nuclei assessed by propidium iodide (PI) staining; and the percentages of apoptotic and necrotic cells quantified by morphological observation and fluorescein labeled annexin-V binding.	Propidium	259-275	regulator of MON1-CCZ1	Mus musculus	39-44
10537040-2	1999	Expression of the neuronal (EAAT3) or glial (EAAT2) transporters was inhibited with antisense phosphothioate oligonucleotides, and cytotoxicity was assessed with propidium iodide uptake.	Propidium	162-178	solute carrier family 1 member 1	Rattus norvegicus	28-33
10537040-2	1999	Expression of the neuronal (EAAT3) or glial (EAAT2) transporters was inhibited with antisense phosphothioate oligonucleotides, and cytotoxicity was assessed with propidium iodide uptake.	Propidium	162-178	solute carrier family 1 member 2	Rattus norvegicus	45-50
10477576-5	1999	Flow cytometry analyses of propidium iodide-stained cells demonstrated cell death of all four cell lines, as judged by the presence of cells with hypodiploid DNA content after exposure of cells to TNF-alpha for 4 days.	Propidium	27-43	tumor necrosis factor	Homo sapiens	197-206
10454569-6	1999	Cell cycle analysis with propidium iodide revealed that CD11b expression at 24 h following initiation of differentiation occurs at all phases of the cell cycle instead of only those cells arrested in G(0)/G(1).	Propidium	25-41	integrin subunit alpha M	Homo sapiens	56-61
10385649-9	1999	Using propidium iodide and fluorescence microscopy, we found that both TNF-alpha and Kupffer cell activation were necessary to drive hepatocytes toward lethal injury.	Propidium	6-22	tumor necrosis factor	Rattus norvegicus	71-80
9890890-6	1999	Previous reaction schemes for substrate hydrolysis by AChE were extended to include product dissociation steps, and acetylthiocholine hydrolysis rates in the presence of propidium under nonequilibrium conditions were simulated with assigned rate constants in the program SCoP.	Propidium	170-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	54-58
9841784-3	1999	Through a combination of flow cytometry of propidium iodide-stained cells and mathematical modeling we showed that the deletion of the SNF4 gene provoked a decrease in the length of G1 with respect to the WT strain along with a smaller difference in the cell cycle length of parent and daughter cells.	Propidium	43-59	AMP-activated serine/threonine-protein kinase regulatory subunit SNF4	Saccharomyces cerevisiae S288C	135-139
9845437-0	1998	Propidium iodide quenches the fluorescence of TdT-incorporated FITC-labeled dUTP in apoptotic cells.	Propidium	0-16	DNA nucleotidylexotransferase	Homo sapiens	46-49
9851850-4	1998	Propidium iodine staining revealed that the greatest reduction in apoptosis and the largest increase in cell numbers occurred in the tetraploid germ cell population of p53-/- mice.	Propidium	0-16	transformation related protein 53, pseudogene	Mus musculus	168-171
9811569-3	1998	By comparing the HMG-I-dependent fluorescence signal with the chromatin density determined by Hoechst 33342 or propidium iodide staining, we present evidence for the existence of three HMG-I sub-populations whose contribution to the total fluorescence can be determined using a newly developed quantitative co-localization image analysis program: foci that correspond to regions of heterochromatin, intense dots located within decondensed chromatin, and a more diffuse component extending throughout the nucleoplasm.	Propidium	111-127	high mobility group AT-hook 1	Mus musculus	185-190
9811465-3	1998	We found that compared to the parental cell line, cells overexpressing mutant p53 (either 246val or 135ser) exhibited decreased apoptosis in response to gamma-radiation or cisplatin as measured by: propidium iodide (PI) staining of the cellular DNA (cell cycle analysis) and decrease in PARP (poly ADP-ribose polymerase) cleavage as detected by Western blotting.	Propidium	198-214	tumor protein p53	Homo sapiens	78-81
9822350-6	1998	NF-kappaB was detected immunocytochemically with FITC-tagged antibody and its presence in the nucleus vis-a-vis cytoplasm was monitored by measuring the green fluorescence integrated over the nucleus, which was counterstained with propidium iodide (PI), and over the cytoplasm, respectively.	Propidium	231-247	nuclear factor kappa B subunit 1	Homo sapiens	0-9
9790903-6	1998	The PARP II-transformed cells incorporated propidium iodide after induction; however, Annexin V and TUNEL analysis indicated these changes were not due to apoptosis.	Propidium	43-59	Poly-(ADP-ribose) polymerase	Drosophila melanogaster	4-8
9637767-4	1998	The fucose-specific lectin Aleuria aurantia agglutinin (AAA) rapidly rendered B cells permeable to propidium iodide.	Propidium	99-115	galectin 3	Gallus gallus	20-26
9665813-3	1998	A direct relationship was found to exist between cell viability (propidium iodide uptake) and the magnitude of lysine-dependent plasminogen binding, with apoptotic and dead subpopulations of cells binding up to 100-fold more plasminogen than viable cells.	Propidium	65-81	plasminogen	Homo sapiens	128-139
9665822-1	1998	Upon transforming growth factor-beta (TGF-beta) treatment, Ramos cells, a B-cell lymphoma cell line, undergo apoptosis, as measured by annexin V labeling, DNA fragmentation, and propidium iodide staining.	Propidium	178-194	transforming growth factor beta 1	Homo sapiens	5-36
9665822-1	1998	Upon transforming growth factor-beta (TGF-beta) treatment, Ramos cells, a B-cell lymphoma cell line, undergo apoptosis, as measured by annexin V labeling, DNA fragmentation, and propidium iodide staining.	Propidium	178-194	transforming growth factor beta 1	Homo sapiens	38-46
9712361-4	1998	Moreover, IFN-alpha/beta also decreased cell death in LPS/IFN-gamma-activated cells, as determined by the reduction in the content of oligonucleosomal DNA fragments, in the binding of annexin V to the plasma membrane, and in the amount of hypodiploid cells when analyzed by flow cytometry after in vivo staining with propidium iodide.	Propidium	317-333	interferon alpha	Mus musculus	10-19
9712361-4	1998	Moreover, IFN-alpha/beta also decreased cell death in LPS/IFN-gamma-activated cells, as determined by the reduction in the content of oligonucleosomal DNA fragments, in the binding of annexin V to the plasma membrane, and in the amount of hypodiploid cells when analyzed by flow cytometry after in vivo staining with propidium iodide.	Propidium	317-333	interferon gamma	Mus musculus	58-67
9751257-3	1998	We report that the galNAc-binding ML III incubated with human lymphocytes mediates a very effective death signal resulting in the binding of Annexin-V and expression of mitochondrial membrane proteins Apo2.7, but also in an influx of the DNA intercalating dye propidium iodide.	Propidium	260-276	annexin A5	Homo sapiens	141-150
9751257-3	1998	We report that the galNAc-binding ML III incubated with human lymphocytes mediates a very effective death signal resulting in the binding of Annexin-V and expression of mitochondrial membrane proteins Apo2.7, but also in an influx of the DNA intercalating dye propidium iodide.	Propidium	260-276	TNF receptor superfamily member 10a	Homo sapiens	201-205
9701026-2	1998	The PKC-specific inhibitor GF 109203X and the proposed cPKC-specific inhibitor Go 6976, in a concentration-dependent manner, increased the percentage of cells undergoing apoptosis induced by anti-CD95 mAb as demonstrated by propidium iodide (PI) staining, TUNEL assay and DNA fragmentation by gel electrophoresis.	Propidium	224-240	Fas cell surface death receptor	Homo sapiens	196-200
9669031-3	1998	Apoptosis of the IGFII antisense-treated cells was quantitated by both nuclear condensation and flow cytometry after cells were stained with propidium iodide.	Propidium	141-157	insulin like growth factor 2	Homo sapiens	17-22
9607806-7	1998	Confocal microscopy of kidney sections costained with the 11betaHSD2 antibody and the nuclear marker propidium iodide demonstrated that 11betaHSD2 is in the cytoplasmic compartment with no evidence for nuclear localization.	Propidium	101-117	11-beta-hydroxysteroid dehydrogenase type 2	Oryctolagus cuniculus	136-146
9425034-2	1998	The mechanism of inhibition of acetylcholinesterase by these monoclonal antibodies was further investigated by determining their effect on (i) substrate inhibition due to the binding of excess substrate to the peripheral anionic site and (ii) binding of peripheral anionic site ligands, such as propidium and fasciculin.	Propidium	295-304	acetylcholinesterase (Cartwright blood group)	Homo sapiens	31-51
9535822-8	1998	Cells with a fractional DNA content also increased five-fold in the HGF/SF-treated cultures as analyzed by flow cytometry after propidium iodide staining.	Propidium	128-144	hepatocyte growth factor	Mus musculus	68-74
9602434-3	1998	Such CT-1-treated cells are protected against subsequent exposure to severe thermal or ischaemic stress, as assayed both by measures of total cell death, such as trypan blue exclusion and LDH release, and by measures of apoptosis, such as propidium-iodide-staining and TUNEL-labelling.	Propidium	239-255	cardiotrophin 1	Homo sapiens	5-9
9547363-9	1998	Propidium slowed the reactivation of 7-(methylethoxyphosphinyloxy)-1- methylquinolinium iodide-inhibited AChE by all oximes.	Propidium	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	105-109
9521743-9	1998	Direct measurements with the acylation site ligands huperzine A and m-(N,N, N-trimethylammonio)trifluoroacetophenone showed that bound propidium decreased the association rate constants 49- and 380-fold and the dissociation rate constants 10- and 60-fold, respectively, relative to the rate constants for these acylation site ligands with free AChE, in reasonable agreement with the nonequilibrium steric blockade model.	Propidium	135-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	344-348
9521743-10	1998	We conclude that this model can account for the inhibition of AChE by small peripheral site ligands such as propidium without invoking any conformational interaction between the peripheral and acylation sites.	Propidium	108-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
9425034-4	1998	The results also show that propidium clearly slowed the inhibition of fetal bovine serum acetylcholinesterase by all six inhibitory monoclonal antibodies but to different levels.	Propidium	27-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-109
9486921-8	1998	The percentage of apoptosis in lymphocyte subfractions was measured in freshly prepared cell samples by FCM with FITC-labeled Annexin V in the propidium iodide-negative (non-necrotic) cell fraction.	Propidium	143-159	annexin A5	Homo sapiens	126-135
9292533-4	1997	Treatment of MM cells with MDM2 antisense, but not sense, nonsense, or scrambled, oligodeoxyribonucleotides (ODNs) decreased DNA synthesis and cell viability; it also induced G1 growth arrest, as evidenced by propidium iodide (PI) staining and induction of retinoblastoma protein (pRB) to E2F-1 binding.	Propidium	209-225	MDM2 proto-oncogene	Homo sapiens	27-31
9391124-7	1997	Furthermore, an association between JAK3 and STAT-1, STAT-3, and STAT-5 activation and cell-cycle progression was demonstrated by both propidium iodide staining and bromodeoxyuridine incorporation in cells of four patients tested.	Propidium	135-151	Janus kinase 3	Homo sapiens	36-40
9391124-7	1997	Furthermore, an association between JAK3 and STAT-1, STAT-3, and STAT-5 activation and cell-cycle progression was demonstrated by both propidium iodide staining and bromodeoxyuridine incorporation in cells of four patients tested.	Propidium	135-151	signal transducer and activator of transcription 1	Homo sapiens	45-51
9391124-7	1997	Furthermore, an association between JAK3 and STAT-1, STAT-3, and STAT-5 activation and cell-cycle progression was demonstrated by both propidium iodide staining and bromodeoxyuridine incorporation in cells of four patients tested.	Propidium	135-151	signal transducer and activator of transcription 5A	Homo sapiens	65-71
9362504-2	1997	By laser scanning confocal microscopy of rat central nervous tissue and C6 glioma cells, we found that a significant portion of the glypican and biglycan immunoreactivity colocalized with nuclear staining by propidium iodide and was also seen in isolated nuclei.	Propidium	208-224	glypican 1	Homo sapiens	132-140
9362504-2	1997	By laser scanning confocal microscopy of rat central nervous tissue and C6 glioma cells, we found that a significant portion of the glypican and biglycan immunoreactivity colocalized with nuclear staining by propidium iodide and was also seen in isolated nuclei.	Propidium	208-224	biglycan	Rattus norvegicus	145-153
9405519-5	1997	A substantial decrease in the IsAHP was observed even when the stimulus preceded the depolarizing pulse by >/=30 s. However applications of peripheral site AChE inhibitors decamethonium and propidium caused only minor or no enhancement of the IsAHP reduction after the afferent stimulus.	Propidium	193-202	acetylcholinesterase	Rattus norvegicus	159-163
9469637-4	1997	In this study, we investigated whether continuous application of basic fibroblast growth factor (bFGF or FGF-2) and brain-derived neurotrophic factor (BDNF) inhibited neuronal cell death induced by serum-deprivation in organotypic culture using propidium iodide staining, and we analyzed effects of bFGF and BDNF on the formation of neuronal circuits using the optical recording system.	Propidium	245-261	brain derived neurotrophic factor	Homo sapiens	116-149
9469637-4	1997	In this study, we investigated whether continuous application of basic fibroblast growth factor (bFGF or FGF-2) and brain-derived neurotrophic factor (BDNF) inhibited neuronal cell death induced by serum-deprivation in organotypic culture using propidium iodide staining, and we analyzed effects of bFGF and BDNF on the formation of neuronal circuits using the optical recording system.	Propidium	245-261	brain derived neurotrophic factor	Homo sapiens	151-155
9371525-6	1997	Double labeling with propidium iodide showed a decrease in HSP-70 in all the phases of the cell cycle concomitant with a reduced percentage of cycling cells in ATRA-treated samples.	Propidium	21-37	heat shock protein family A (Hsp70) member 4	Homo sapiens	59-65
9310474-5	1997	On the other hand, the number of platelets released in the culture supernatant by CD34-derived megakaryocytes peaked at days 18 to 21, when a high percentage of megakaryocytes showed the characteristic features of apoptosis, as evaluated by electron microscopy, terminal deoxynucleotidyl transferase (TdT)-mediated d-UTP-biotin nick end-labeling technique (TUNEL) and uptake of propidium iodide.	Propidium	378-394	CD34 molecule	Homo sapiens	82-86
9413156-1	1997	Interleukin-18 (IL-18) induces apoptosis in human myelomonocytic KG-1 cells as determined by agarose gel electrophoresis, and flow cytometry after propidium iodide (PI) staining.	Propidium	147-163	interleukin 18	Homo sapiens	0-14
9413156-1	1997	Interleukin-18 (IL-18) induces apoptosis in human myelomonocytic KG-1 cells as determined by agarose gel electrophoresis, and flow cytometry after propidium iodide (PI) staining.	Propidium	147-163	interleukin 18	Homo sapiens	16-21
8978296-3	1997	Treatment with anti-Fas (7C11) monoclonal antibody (MoAb) induced apoptosis, evidenced by internucleosomal DNA fragmentation and propidium iodide staining, and was associated with increased expression of c-jun early response gene.	Propidium	129-145	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-209
9303487-7	1997	GJIC measured by propidium iodide, which indicated the function of Cx26, decreased from before the onset of the S phase and then increased slightly in the S/M phase.	Propidium	17-33	gap junction protein, beta 2	Rattus norvegicus	67-71
9363328-5	1997	Specific terminal deoxynucleotidyl transferase-(TdT) mediated labeling of 3"-OH ends of DNA nicks corroborated the flow cytometric profiles of propidium iodide-DNA binding where degradation of both 2 and 4 N genomic DNA resulted in a solitary 1N peak presentation.	Propidium	143-159	DNA nucleotidylexotransferase	Homo sapiens	48-51
9066788-4	1997	Flow cytometric analysis of M-07e cells labeled with hypotonic propidium iodide demonstrates that the percentage of cells undergoing DNA synthesis decreases from 24%, in a log phase population of IL-3 stimulated cells, to 1% when cells are deprived of IL-3 for 24 hours.	Propidium	63-79	interleukin 3	Homo sapiens	196-200
9224640-7	1997	Finally, we report that IL-4 delays neutrophil apoptosis, as assessed by morphological observations from cytocentrifuge preparations, as well as by measurement of differences in staining by flow cytometry with both propidium iodide and Hoechst reagent.	Propidium	215-231	interleukin 4	Homo sapiens	24-28
9232246-4	1997	Using three different assays of cellular toxicity (propidium iodide, BCECF-AM and Trypan Blue), the PAPA complexes caused minimal cellular toxicity.	Propidium	51-67	pappalysin 1	Homo sapiens	100-104
9224560-4	1997	In reverse micelles, some inhibitors of AChE (propidium, and d-tubocurarine) have much less effect upon indophenol-acetate hydrolysis than they do in a dilute solution environment.	Propidium	46-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-44
9184696-9	1997	The apoptosis of SAC-activated B cells by IL-10 was further confirmed by propidium iodide-staining and Annexin V-FITC-staining methods.	Propidium	73-89	interleukin 10	Homo sapiens	42-47
9154341-4	1997	Extracellular Na+ removal, which activates the Na(+)-Ca2+ exchanger as a Na+ efflux pathway and prevents Na+ entrance, significantly reduced LDH release and the number of propidium iodide positive C6 cells.	Propidium	171-187	solute carrier family 8 member A1	Homo sapiens	47-67
9094628-6	1997	In addition, the Ets-NF-kappaB/NFAT interaction requires the presence of DNA binding sites for both proteins, as it is abolished by the DNA intercalating agents propidium iodide and ethidium bromide and enhanced by the presence of synthetic oligonucleotides containing binding sites for Ets and NF-kappaB proteins.	Propidium	161-177	nuclear factor kappa B subunit 1	Homo sapiens	21-30
9094628-6	1997	In addition, the Ets-NF-kappaB/NFAT interaction requires the presence of DNA binding sites for both proteins, as it is abolished by the DNA intercalating agents propidium iodide and ethidium bromide and enhanced by the presence of synthetic oligonucleotides containing binding sites for Ets and NF-kappaB proteins.	Propidium	161-177	nuclear factor kappa B subunit 1	Homo sapiens	295-304
9141622-4	1997	Specific antibodies were used to measure hsp70 in cells costained with propidium iodide.	Propidium	71-87	heat shock protein family A (Hsp70) member 4	Homo sapiens	41-46
8608006-3	1996	The action of AChE was independent of the subunit array of the enzyme, was not affected by edrophonium, an active site inhibitor, but it was affected by propidium, a peripheral anionic binding site ligand.	Propidium	153-162	acetylcholinesterase	Mus musculus	14-18
8977247-9	1996	Flow cytometry and morphologic analysis of propidium iodide stained cells showed significantly lower levels of apoptosis in FAC-retroviral transduced cells after growth factor deprivation.	Propidium	43-59	FA complementation group C	Homo sapiens	124-127
8933373-4	1996	In contrast, surface 22C11 and 4G8 beta APP immunoreactivity was abundant on intact (propidium iodide-excluding) dissociated brain cells.	Propidium	85-101	amyloid beta (A4) precursor protein	Mus musculus	35-43
8836046-7	1996	Treatment of hepatocytes with group II PLA2-specific anti-sense DNA oligonucleotides: 1) abolished accumulation of PLA2 protein in hypoxic rat hepatocytes as assessed by immunofluorescence staining with anti-PLA2 antibodies; 2) decreased the enzymatic activity of PLA2 manifested as decreased arachidonic acid release in hypoxic hepatocytes; and 3) significantly delayed cell death evoked by chemical hypoxia as indicated by a decrease in propidium iodide uptake.	Propidium	439-455	phospholipase A2 group IB	Rattus norvegicus	39-43
8836046-7	1996	Treatment of hepatocytes with group II PLA2-specific anti-sense DNA oligonucleotides: 1) abolished accumulation of PLA2 protein in hypoxic rat hepatocytes as assessed by immunofluorescence staining with anti-PLA2 antibodies; 2) decreased the enzymatic activity of PLA2 manifested as decreased arachidonic acid release in hypoxic hepatocytes; and 3) significantly delayed cell death evoked by chemical hypoxia as indicated by a decrease in propidium iodide uptake.	Propidium	439-455	phospholipase A2 group IB	Rattus norvegicus	115-119
8836046-7	1996	Treatment of hepatocytes with group II PLA2-specific anti-sense DNA oligonucleotides: 1) abolished accumulation of PLA2 protein in hypoxic rat hepatocytes as assessed by immunofluorescence staining with anti-PLA2 antibodies; 2) decreased the enzymatic activity of PLA2 manifested as decreased arachidonic acid release in hypoxic hepatocytes; and 3) significantly delayed cell death evoked by chemical hypoxia as indicated by a decrease in propidium iodide uptake.	Propidium	439-455	phospholipase A2 group IB	Rattus norvegicus	115-119
8836046-7	1996	Treatment of hepatocytes with group II PLA2-specific anti-sense DNA oligonucleotides: 1) abolished accumulation of PLA2 protein in hypoxic rat hepatocytes as assessed by immunofluorescence staining with anti-PLA2 antibodies; 2) decreased the enzymatic activity of PLA2 manifested as decreased arachidonic acid release in hypoxic hepatocytes; and 3) significantly delayed cell death evoked by chemical hypoxia as indicated by a decrease in propidium iodide uptake.	Propidium	439-455	phospholipase A2 group IB	Rattus norvegicus	115-119
8817073-1	1996	A Noti-linking clone NL1-210 (D3S1656) that contains the human MAP kinase activated protein kinase (3PK) gene was localized to 3p21.2 on DAPI-banded and propidium iodide (R-bands)-stained chromosomes by fluorescence in situ hybridization (FISH).	Propidium	153-169	MAPK activated protein kinase 3	Homo sapiens	100-103
8724699-8	1996	TPO suppresses growth factor withdrawal-induced apoptosis as evaluated by flow cytometric detection of both in situ terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling and cellular DNA content via propidium iodide staining.	Propidium	215-231	thrombopoietin	Homo sapiens	0-3
8993839-5	1997	4-HPR exposure to PC-3 cells in vitro was associated with apoptosis as evidenced by increased incidence of hypodiploid nuclei in propidium iodide fluorescence histograms and DNA fragmentation.	Propidium	129-145	haptoglobin-related protein	Homo sapiens	2-5
8903477-2	1996	Either the RIPs or the immunotoxins induced apoptosis in the CD30+ L540 cell line, as shown by the morphological aspects of the cells, by the DNA fragmentation visible at the electrophoresis, and by the formation of DNA breaks evidenced by 2 cytofluorometric techniques (propidium-iodide staining and fluoresceine-isothiocyanate conjugate dUTP incorporation).	Propidium	271-287	TNF receptor superfamily member 8	Homo sapiens	61-65
9051118-6	1996	LR73-R cells transfected with mdr1 cDNA exhibited only a very limited change in propidium iodide staining as compared with sensitive LR73 cells, suggesting that mdr1 gene overexpression alone could not account for the alterations in DNA content observed in the selected MDR cells.	Propidium	80-96	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
8759755-10	1996	Furthermore, IL-13 at a concentration of 100 ng/ml enhanced eosinophil viability, as assessed by propidium iodide staining after 4 days in culture from 8.6 +/- 5.5% in control medium to 50.7 +/- 6.8% following stimulation with IL-13 treatment.	Propidium	97-113	interleukin 13	Homo sapiens	13-18
8639799-5	1996	By contrast, the propidium iodide (PI) staining of the DNA content showed that IL-8 could prolong the survival of resting B-CLL cells in 11 of 16 cases studied.	Propidium	17-33	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
8928916-5	1996	Propidium iodide staining of the vascular endothelium revealed a significant increase in the number of dead endothelial cells on the aortic vessel rings following hypoxia-reoxygenation, but not on those pretreated with superoxide dismutase and catalase.	Propidium	0-16	catalase	Rattus norvegicus	244-252
8615975-10	1996	Propidium iodide-Hoechst 33342 double staining confirmed that TNF-alpha-induced nuclear alterations precede permeabilization of the plasma membrane, supporting cell death in these tumor cells by apoptosis.	Propidium	0-16	tumor necrosis factor	Homo sapiens	62-71
8603407-2	1996	The arrested WEHI cells (60-75% in G0-G1) showed increased sensitivity to TNF killing, measured as 48-h 3-(5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assays, and 15-h apoptosis by propidium iodide staining and flow cytometry analysis.	Propidium	194-210	tumor necrosis factor	Mus musculus	74-77
21544432-5	1996	Additionally, the c-myb antisense ODN induced apoptosis of Raji cells as demonstrated by i) flow cytometry to enumerate the A(o) (apoptotic cell population) population of propidium iodide stained cells; ii) electron microscopy to evaluate the cell morphology; and iii) DNA fragmentation pattern.	Propidium	171-187	MYB proto-oncogene, transcription factor	Homo sapiens	18-23
9345430-4	1996	The counteracting effect of IFN-alpha/IFN-beta against IFN-gamma-induced astrocytic proliferation was verified by the DNA content distribution analysis of propidium iodide-labeled cells.	Propidium	155-171	interferon beta 1	Homo sapiens	38-46
9345430-4	1996	The counteracting effect of IFN-alpha/IFN-beta against IFN-gamma-induced astrocytic proliferation was verified by the DNA content distribution analysis of propidium iodide-labeled cells.	Propidium	155-171	interferon gamma	Homo sapiens	55-64
7492545-1	1995	Replacement of residues Asp74, Trp286, and Tyr72, which are constituents of the peripheral anionic site (PAS) of human acetylcholinesterase (HuAChE), affected similarly both the binding and the inhibition constants of the PAS-specific ligand propidium, demonstrating that changes in the inhibitory activity are a direct consequence of altered binding to the PAS.	Propidium	242-251	acetylcholinesterase (Cartwright blood group)	Homo sapiens	119-139
8750823-5	1995	An association was observed between cell death, as determined by propidium iodide (PI) staining, and Fos-lacZ expression.	Propidium	65-81	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	101-104
8745009-1	1995	The flow cytometric assay method was tested for the cytotoxic activity of Clostridium perfringens enterotoxin (CPE) in culture using mouse mammary carcinoma cell line FM3A stained with propidium iodide (PI).	Propidium	185-201	cpe	Clostridium perfringens	74-109
8745009-1	1995	The flow cytometric assay method was tested for the cytotoxic activity of Clostridium perfringens enterotoxin (CPE) in culture using mouse mammary carcinoma cell line FM3A stained with propidium iodide (PI).	Propidium	185-201	cpe	Clostridium perfringens	111-114
9345430-4	1996	The counteracting effect of IFN-alpha/IFN-beta against IFN-gamma-induced astrocytic proliferation was verified by the DNA content distribution analysis of propidium iodide-labeled cells.	Propidium	155-171	interferon alpha 1	Homo sapiens	28-37
8632908-1	1996	The anti-proliferative effect of nerve growth factor (NGF) on the rat pheochromocytoma cell line PC12 has been previously shown to be accompanied by the accumulation of cells in either the G1 phase with a 2c DNA content, or with a 4c DNA content characteristic for G2/M, as evidenced by flow cytometric analysis of DNA distribution using propidium iodide.	Propidium	338-354	nerve growth factor	Rattus norvegicus	33-52
8632908-1	1996	The anti-proliferative effect of nerve growth factor (NGF) on the rat pheochromocytoma cell line PC12 has been previously shown to be accompanied by the accumulation of cells in either the G1 phase with a 2c DNA content, or with a 4c DNA content characteristic for G2/M, as evidenced by flow cytometric analysis of DNA distribution using propidium iodide.	Propidium	338-354	nerve growth factor	Rattus norvegicus	54-57
8613675-3	1996	The method is based on the binding of propidium iodide (PI), a membrane-impermeant dye, to nucleic acids of WEHI 164 cells, whose plasma membrane permeable due to TNF-alpha-induced cell damage.	Propidium	38-54	tumor necrosis factor	Mus musculus	163-172
8937686-9	1996	Staining with propidium iodide revealed that a significantly higher proportion of Thy1+ T cells in DP than in DR rats are in cycle (S/G2/M), thereby accounting for their disproportionately high numbers relative to RTE"s.	Propidium	14-30	Thy-1 cell surface antigen	Rattus norvegicus	82-86
7556436-2	1995	A two-parameter flow cytometric analysis using propidium iodide and UNG-specific antibodies demonstrated that total cellular UNG increased during the G1-phase and was approximately doubled in early S-phase compared to early G1.	Propidium	47-63	uracil DNA glycosylase	Homo sapiens	125-128
7593215-2	1995	In this study, flow cytometry was used to investigate hsp72 levels through the cell cycle in HeLa cells by dual labeling with propidium iodide and antibodies against hsp72.	Propidium	126-142	heat shock protein family A (Hsp70) member 1A	Homo sapiens	54-59
7475302-3	1995	By immunofluorescence and propidium-iodide staining apoptin was shown to induce apoptosis in all analysed cell lines.	Propidium	26-42	APOPTIN;hypothetical protein;nucleocapsid protein	Chicken anemia virus	52-59
7882385-3	1995	When Molt-4 and other tumor cells were treated in vitro with HSP70 antisense oligomer, they displayed propidium-iodide-stained condensed nuclei (intact or fragmented).	Propidium	102-118	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
7537274-4	1995	On the other hand, propidium iodide and ethidium bromide penetrate very poorly or not at all through Cx31 and Cx32 channels, respectively, but pass through channels of other connexins.	Propidium	19-35	gap junction protein beta 3	Homo sapiens	101-105
7537274-4	1995	On the other hand, propidium iodide and ethidium bromide penetrate very poorly or not at all through Cx31 and Cx32 channels, respectively, but pass through channels of other connexins.	Propidium	19-35	gap junction protein beta 1	Homo sapiens	110-114
7632460-4	1995	Flow cytometric analysis using Hoechst 33342 and propidium iodide staining revealed that the Tat transfectants exhibited a higher percentage of apoptotic cells when compared to the control transfectants (29.1 +/- 3.1 vs. 11.43 +/- 3.1%).	Propidium	49-65	tyrosine aminotransferase	Homo sapiens	93-96
7599168-1	1995	Both propidium and monoclonal antibody (mAb) 25B1 bind to the peripheral anionic site region of fetal bovine serum acetylcholinesterase (FBS AChE).	Propidium	5-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	141-145
7572288-8	1995	In contrast to oligodendrocytes, the extent of DNA fragmentation, assessed by propidium iodide staining, induced in neurons by tumor necrosis factor alpha was less than that induced by serum deprivation.	Propidium	78-94	tumor necrosis factor	Homo sapiens	127-154
7763236-3	1995	Using immunofluorescence microscopy and staining by propidium iodide, we showed HUVEC treated with TGF-beta 1 contained characteristic apoptotic nuclei with condensation of chromatin.	Propidium	52-68	transforming growth factor beta 1	Homo sapiens	99-109
7742549-8	1995	Cell cycle analysis by flow cytometry after staining with propidium iodide consistently showed that more than 96% of the cells were in G0/G1 phase, whatever the importance of cyclin D2 overexpression was, and that cyclin D2 overexpression in B-CLL was not associated with any modifications of the cell cycle repartition.	Propidium	58-74	cyclin D2	Homo sapiens	214-223
7722292-5	1995	When IL-10 was present during the initial activation of B cells with SA, IL-10 facilitated the apoptosis of SA-activated B cells, as determined by staining with propidium iodide, followed by analysis with flow cytometry, thus resulting in very modest IgM production.	Propidium	161-177	interleukin 10	Homo sapiens	5-10
7722292-5	1995	When IL-10 was present during the initial activation of B cells with SA, IL-10 facilitated the apoptosis of SA-activated B cells, as determined by staining with propidium iodide, followed by analysis with flow cytometry, thus resulting in very modest IgM production.	Propidium	161-177	interleukin 10	Homo sapiens	73-78
8001460-3	1994	Exponential monolayers showed decrease of EGFR content after 20 min pulses with 10 ng/ml EGF in medium, as detected with the antibody EGFR1 in a double staining technique with propidium iodide for DNA evaluation.	Propidium	176-192	epidermal growth factor receptor	Homo sapiens	42-46
8747598-4	1995	The onset of cellular damage in TNFs cells, as indicated by propidium iodide uptake, was seen as early as 6 h after TNF-alpha treatment.	Propidium	60-76	tumor necrosis factor	Mus musculus	116-125
7700583-1	1994	We have investigated the use of the fluorescent exclusion dye propidium iodide as a marker for acutely degenerating cells in vivo, and report here that combined injection of kainic acid and propidium iodide into the lateral cerebral ventricle results in labelling of CA3 pyramidal cells 1 and 6 h after injection.	Propidium	62-78	carbonic anhydrase 3	Rattus norvegicus	267-270
7700583-1	1994	We have investigated the use of the fluorescent exclusion dye propidium iodide as a marker for acutely degenerating cells in vivo, and report here that combined injection of kainic acid and propidium iodide into the lateral cerebral ventricle results in labelling of CA3 pyramidal cells 1 and 6 h after injection.	Propidium	190-206	carbonic anhydrase 3	Rattus norvegicus	267-270
7866281-7	1994	Cell cycle analysis using propidium iodide as a DNA stain demonstrated that CsA prohibited the progression of B-CLL cells from the G1-phase to the S-phase of the cell cycle.	Propidium	26-42	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	76-79
7824193-3	1994	The intensity of propidium iodide fluorescence in hippocampal area CA1 was quantified using Optimas image analysis software.	Propidium	17-33	carbonic anhydrase 1	Homo sapiens	67-70
8205548-8	1994	Analysis of propidium iodide-stained nuclei by flow cytometry after cisplatin or etoposide treatment revealed marked DNA degradation in vector-transfected controls whereas bcl-2 transfectants showed a dose-dependent inhibition of DNA degradation.	Propidium	12-28	BCL2 apoptosis regulator	Homo sapiens	172-177
8181067-3	1994	IFN-alpha alone had no effect on either the IL-2 production or apoptosis of MOLT-16 cells, but significantly increased both the IL-2 production and apoptosis in the MOLT-16 cells after phytohemagglutinin (PHA) stimulation as determined by CTLL-2 assay and by flow cytometric analysis using propidium iodide (PI) staining.	Propidium	290-306	interferon alpha 1	Homo sapiens	0-9
7515098-6	1994	DNA content analysis using flow cytometry after staining with propidium iodide revealed that the treatment of M07E cells with FN did not block the entry of the cells into the cell cycle after stimulation with GM-CSF or SCF, whereas the treatment resulted in the appearance of subdiploid peak.	Propidium	62-78	fibronectin 1	Homo sapiens	126-128
8181532-1	1994	The present study demonstrates that an agonistic anti-CD38 monoclonal antibody (mAb) (IB4) is capable of preventing apoptosis of human tonsillar germinal center (GC) B cells as measured by either morphological methods on Giemsa-stained cytospin preparations or flow cytometry on propidium iodide-stained cells.	Propidium	279-295	CD38 molecule	Homo sapiens	54-58
8132337-9	1994	Membranes of cells treated with high toxin doses (> 300 nM) became permeable to both Ca2+ and propidium iodide.	Propidium	97-113	AT695_RS01930	Staphylococcus aureus	37-42
8509385-6	1993	It is also prevented by propidium iodide, BW284C51, and d-tubocurarine, which bind to peripheral anionic sites of AChE, by Ca2+ and Mg2+, known to enhance AChE activity through an allosteric phenomenon and by acetylthiocholine concentrations which lead to excess substrate inhibition of the enzyme.	Propidium	24-40	acetylcholinesterase	Rattus norvegicus	114-118
8114681-1	1994	Comparison of the effect of three "peripheral" site ligands, propidium, d-tubocurarine, and gallamine, on acetylcholinesterase (acetylcholine hydrolase; EC 3.1.1.7) of Torpedo and chicken shows that all three are substantially more effective inhibitors of the Torpedo enzyme than of the chicken enzyme.	Propidium	61-70	acetylcholinesterase (Cartwright blood group)	Gallus gallus	106-126
8243565-5	1993	TNF-alpha-induced apoptosis (10(4) U/mL) as measured by multiparameter flow cytometry (propidium iodide [PI]) paralleled the functional decrease in cell viability (MTT assay) of 20 +/- 3% after 24 hours up to a maximum of 50 +/- 4% after 48 hours.	Propidium	87-103	tumor necrosis factor	Homo sapiens	0-9
8104799-7	1993	Propidium iodide staining together with immunofluorescence showed that the apoptotic cells were indeed CD4+ lymphocytes.	Propidium	0-16	CD4 molecule	Homo sapiens	103-106
8272483-1	1993	Treatment of Rhesus monkey peripheral blood lymphocytes and IL-2 dependent cell lines with heat prior to incubation with mitogens or IL-2, respectively, induces significant cell changes at the nuclear level, detected by DNA staining with Vindelov"s propidium iodide and the simultaneous measurement of its red fluorescence and 90 degrees light scatter.	Propidium	249-265	interleukin 2	Macaca mulatta	60-64
8272483-1	1993	Treatment of Rhesus monkey peripheral blood lymphocytes and IL-2 dependent cell lines with heat prior to incubation with mitogens or IL-2, respectively, induces significant cell changes at the nuclear level, detected by DNA staining with Vindelov"s propidium iodide and the simultaneous measurement of its red fluorescence and 90 degrees light scatter.	Propidium	249-265	interleukin 2	Macaca mulatta	133-137
8335944-5	1993	By a propidium iodide incorporation assay and by 51Cr release assay, antibody-sensitized CHO cells expressing MCP were protected from C-mediated cytotoxicity.	Propidium	5-21	membrane cofactor protein	Cricetulus griseus	110-113
8411809-4	1993	Flow cytometric cell cycle analysis by double staining method with propidium iodide and Proliferating cell nuclear antigen (PCNA) disclosed IL-1 beta caused cell accumulation at G1 phase.	Propidium	67-83	interleukin 1 beta	Homo sapiens	140-149
8133082-2	1994	The proliferation rate of the murine indicator cell line, cytotoxic T lymphoblastic line 2 (CTLL-2) induced by interleukin-2 (IL-2) culture supernatants was determined by staining with the fluorescent DNA dye propidium-iodide.	Propidium	209-225	interleukin 2	Mus musculus	111-124
8133082-2	1994	The proliferation rate of the murine indicator cell line, cytotoxic T lymphoblastic line 2 (CTLL-2) induced by interleukin-2 (IL-2) culture supernatants was determined by staining with the fluorescent DNA dye propidium-iodide.	Propidium	209-225	interleukin 2	Mus musculus	126-130
8307126-0	1994	Neural substrate of a cerebellar movement disorder induced by intracerebroventricular injection of propidium iodide in the rat: a Fos immunocytochemical study.	Propidium	99-115	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	130-133
8254211-13	1994	TTK protein and mRNA expression increased in both fresh PBL and T cell blasts concurrently with passage of cells through S phase as indicated by [3H]TdR incorporation and cell cycle analysis of propidium iodide-stained cells.	Propidium	194-210	TTK protein kinase	Homo sapiens	0-3
8186366-1	1993	Early events in the cytotoxic response to tumour necrosis factor (TNF) of the murine fibrosarcoma cell lines L929 and WEHI164cl13 were assessed on a cell by cell basis using the fluorescent exclusion dye propidium iodide (PI) and analysis by flow cytometry.	Propidium	204-220	tumor necrosis factor	Mus musculus	66-69
8509385-6	1993	It is also prevented by propidium iodide, BW284C51, and d-tubocurarine, which bind to peripheral anionic sites of AChE, by Ca2+ and Mg2+, known to enhance AChE activity through an allosteric phenomenon and by acetylthiocholine concentrations which lead to excess substrate inhibition of the enzyme.	Propidium	24-40	acetylcholinesterase	Rattus norvegicus	155-159
1462732-8	1992	By staining with the vital dye Hoechst 33342 as well as with propidium iodide (PI) it was further possible to show that cell death after IL-3 withdrawal occurred in all phases of the cell cycle.	Propidium	61-77	interleukin 3	Mus musculus	137-141
8417116-6	1993	However, cell cycle analysis of these two fractions by FACS using propidium iodide showed a similar pattern of cell cycle stages in both low and high density populations (G0 + G1 approximately 96 to 98% and S/G2 + M approximately 2 to 4%).	Propidium	66-82	acyl-CoA synthetase long-chain family member 1	Mus musculus	55-59
1359034-3	1992	The in vivo hippocampal pattern of hypoglycemic injury was reproduced by a 2 hr exposure to glucose-free media, which resulted in simultaneous, selective propidium staining of CA1 and the dentate gyrus starting by 4 hr after exposure.	Propidium	154-163	carbonic anhydrase 1	Homo sapiens	176-179
1793833-4	1991	Antibody to CD45 appeared to block the G0(G1) to S phase transition in the cell cycle analysis by propidium iodide staining.	Propidium	98-114	protein tyrosine phosphatase receptor type C	Homo sapiens	12-16
1444832-0	1992	[A rapid measuring technique for allergen-induced IL2 responsiveness of lymphocytes by the propidium iodide-staining method.	Propidium	91-107	interleukin 2	Homo sapiens	50-53
1444832-2	1992	A method for rapidly measuring the interleukin 2 (IL-2)-responsiveness of allergen-stimulated lymphocytes has been newly developed using propidium iodide (PI) staining and drawing ink quenching of the fluid medium fluorescence.	Propidium	137-153	interleukin 2	Homo sapiens	35-48
1444832-2	1992	A method for rapidly measuring the interleukin 2 (IL-2)-responsiveness of allergen-stimulated lymphocytes has been newly developed using propidium iodide (PI) staining and drawing ink quenching of the fluid medium fluorescence.	Propidium	137-153	interleukin 2	Homo sapiens	50-54
1314353-5	1992	Injections of propidium iodide, a tract-tracing agent, into these inversion sites resulted in retrograde labeling of small clusters of choline acetyltransferase (ChAT)-positive neurons in the medial septal nucleus and vertical limb of the diagonal band.	Propidium	14-30	choline O-acetyltransferase	Felis catus	135-160
1371306-5	1992	Flow cytometry analysis with propidium iodide staining revealed that these p-CTL were specifically deleted by incubation with H-2d ABM, but not with H-2k ABM.	Propidium	29-45	histocompatibility 2, D region	Mus musculus	126-130
1538717-3	1992	Propidium association with AchE in the presence of saturating concentrations of THA is characterized by a dissociation constant of 7.7 +/- 0.7 x 10(-6) M, a value within 2-fold of the dissociation constant in the absence of THA.	Propidium	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	27-31
1833074-5	1991	Using propidium iodide staining of the DNA to determine cell cycle stage, we now show that CD45RA expression is significantly higher on T cell clones during the S, G2, and M stages of cell cycle when compared to CD45RA expression on cells in Go and G1.	Propidium	6-22	protein tyrosine phosphatase receptor type C	Homo sapiens	91-95
1717307-6	1991	NMDA (10 microM) caused propidium staining that was limited to CA1 and the dentate gyrus of the cultures, sparing CA3, consistent with the regions of highest NMDA receptor density in vivo.	Propidium	24-33	carbonic anhydrase 1	Homo sapiens	63-66
2340283-10	1990	Hence, the second site of MPT interaction with AChE may overlap or be linked to the peripheral anionic site of AChE characterized by the binding of propidium and other peripheral site inhibitors.	Propidium	148-157	acetylcholinesterase	Mus musculus	47-51
1996483-2	1991	WBC detection is performed by fluorescence analysis of 50 microL of RBCC labeled with propidium iodide, a DNA/RNA fluorophore.	Propidium	86-102	tripartite motif containing 17	Homo sapiens	68-72
1986786-4	1991	Kinetic analysis of the inactivation of AcChE (i) by various concentrations of 1 indicated that it behaves as an affinity label, (ii) at three different pH levels suggested that the pKa of the labelled residue was higher than 7 and (iii) in the presence of different selective ligands for either the active site (edrophonium) or the peripheral site (propidium) indicated that 1 alkylated the active site rather than the peripheral one.	Propidium	350-359	acetylcholinesterase (Cartwright blood group)	Homo sapiens	40-45
1706443-3	1990	Rapid fluorochromasia assay with propidium iodide (RFP) was used for the quantitative measurement of LPT instead of 3H-thymidine uptake.	Propidium	33-49	tripartite motif-containing 27	Mus musculus	51-54
1988120-4	1991	Concentrations as low as 1 microM up to 100 microM SRI 62-834 caused a rapid, dose-dependent increase in membrane permeability, initially towards outward efflux of the preloaded fluorescein probe bis(carboxyethyl)carboxyfluorescein (green fluorescence) and then towards influx of extracellular propidium (red fluorescence).	Propidium	294-303	sorcin	Homo sapiens	51-54
2340283-10	1990	Hence, the second site of MPT interaction with AChE may overlap or be linked to the peripheral anionic site of AChE characterized by the binding of propidium and other peripheral site inhibitors.	Propidium	148-157	acetylcholinesterase	Mus musculus	111-115
34152077-5	2021	Syncollin induces propidium iodide uptake into E. coli (but not L. lactis), indicating permeabilization of the bacterial membrane.	Propidium	18-34	syncollin	Homo sapiens	0-9
2104588-6	1990	The precise action of TRH on GH4 cell proliferation was examined by flow cytometry of fluorescein isothiocyanate-anti-BrdUrd- and propidium iodide-DNA stained cells.	Propidium	130-146	thyrotropin releasing hormone	Rattus norvegicus	22-25
30106144-4	2018	The objective of the present study was to determine the effect of CRT1 on the cell viability, apoptosis and metastasis of SKOV3 human ovarian cancer cells using a Cell Counting Kit-8 assay, flow cytometric analysis of Annexin V-fluorescein isothiocyanate/propidium iodide staining, western blot analysis, soft agar colony forming assay, wound healing assay and Matrigel invasion assay.	Propidium	255-271	hyaluronan and proteoglycan link protein 1	Homo sapiens	66-70
33459158-7	2021	Finally, we confirmed that nlpD maintains C. sakazakii membrane integrity in acid using propidium iodide permeabilization assays via flow cytometry.	Propidium	88-104	murein hydrolase activator NlpD	Cronobacter sakazakii	27-31
34809715-6	2021	METHODS: The anti-apoptotic effect of sevoflurane preconditioning on MSCs was determined by Annexin V-FITC/propidium iodide staining.	Propidium	107-123	annexin A5	Mus musculus	92-101
33235630-7	2021	Both Annexin V-fluorescein isothiocyanate/propidium iodide flow cytometry and western blotting performed to detect proapoptotic factors indicated that MALAT1 depletion might promote KGN cell apoptosis.	Propidium	42-58	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	151-157
34882841-6	2021	Cellular apoptosis was measured using the Annexin V fluorescein isothiocyanate (FITC)-propidium iodide (PI) staining.	Propidium	86-102	annexin A5	Rattus norvegicus	42-51
34817168-2	2021	This study proved that estrogen receptor alpha (ERalpha) could negatively control hepatocyte pyroptosis by inhibiting NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, gasdermin D (GSDMD)-N generation, propidium iodide (PI) uptake, lactate dehydrogenase (LDH) release, and pro-inflammatory cytokine (IL-1beta and IL-18) release.	Propidium	236-252	estrogen receptor 1 (alpha)	Mus musculus	23-46
34817168-2	2021	This study proved that estrogen receptor alpha (ERalpha) could negatively control hepatocyte pyroptosis by inhibiting NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, gasdermin D (GSDMD)-N generation, propidium iodide (PI) uptake, lactate dehydrogenase (LDH) release, and pro-inflammatory cytokine (IL-1beta and IL-18) release.	Propidium	236-252	estrogen receptor 1 (alpha)	Mus musculus	48-55
33622177-8	2021	Annexin V/propidium iodide staining revealed a 30% increase in apoptotic cells at 90 muM chrysophanol (33.7% vs 3.3% in control cultures).	Propidium	10-26	annexin A5	Homo sapiens	0-9
34659510-5	2021	The effect of LGR6 on cell cycle progression and activation of Akt signaling was analyzed by performing propidium iodide staining and western blotting, respectively.	Propidium	104-120	leucine rich repeat containing G protein-coupled receptor 6	Homo sapiens	14-18
34792009-6	2022	The effect of CCNE1 on LUAD cells proliferation and apoptosis was evaluated through Cell Counting Kit-8 (CCK-8), colony formation, and Annexin V/propidium iodide (AV-PI) assays, respectively.	Propidium	145-161	cyclin E1	Mus musculus	14-19
34827176-7	2021	The two ligands normalized significantly (57% and 52% respectively, from 44%; whereas the control was 68%) cell proliferation at different time points from 0-24 h. Additionally, we evaluated the effect of these two TSPO ligands on necrosis using propidium iodide (PI) staining and found that the ligands inhibited significantly the 6-OHDA-induced necrosis.	Propidium	246-262	translocator protein	Rattus norvegicus	215-219
34795590-5	2021	Results: The obtained results show that the availability of chlorogenic acid, vanillin, and salicylic acid levels in CPE is more favorable for enhancing cell growth, nuclear integrity, and mitochondrial efficiency which is confirmed by propidium iodide staining and JC-1 staining.	Propidium	236-252	carboxypeptidase E	Homo sapiens	117-120
34478830-5	2021	The proapoptotic effect and morphological changes induced by 17APAD were detected by Hoechst 33258-propidium iodide or Annexin V-Alexa488-propidium iodide fluorescent double staining methods, supplemented with a caspase-3 activity assay to identify the mechanism behind the programmed cell death induced by 17APAD.	Propidium	138-154	annexin A5	Homo sapiens	119-128
34350670-5	2021	Cell apoptosis was detected by an Annexin V-fluorescein isothiocyanate/propidium iodide assay.	Propidium	71-87	annexin A5	Homo sapiens	34-43
34131854-6	2021	The results of this study showed that this fusion peptide at a concentration of 60.4 microg/mL and 24 h was able to kill half of the tested cancer cells, and treatment of the cells with this concentration increased the expression of bax and caspase 3 genes and reduced the expression of bacl-2 in 24 h. Flow cytometry analysis of annexin V-FITC/propidium iodide results also showed that our peptide was able to induce apoptosis in treated cells compared with control.	Propidium	345-361	annexin A5	Homo sapiens	330-339
34246120-7	2021	Cellular apoptosis was observed from Annexin-V-FITC (fluorescein isothiocyanate)/propidium iodide assay.	Propidium	81-97	annexin A5	Homo sapiens	37-46
34233751-16	2021	Finally, TEX41 expression seems to be critical for leukemic proliferation, indeed, silencing experiments targeting TEX41 mRNA in the RS4;11 cell line hampered in vitro cell growth and cell cycle progression, by inducing G2-M arrest as confirmed propidium iodide staining and by the upregulation of p53 and p21 proteins.	Propidium	245-261	testis expressed 41	Homo sapiens	9-14
34278472-4	2021	Annexin V-fluorescein isothiocyanate/propidium iodide staining, caspase-3 activity measurements and DNA fragmentation assays were performed to detect apoptosis.	Propidium	37-53	annexin A5	Homo sapiens	0-9
34091287-6	2021	Cell cycle analysis and dual staining assays with annexin V-FITC/propidium iodide on MCF-7 cells confirmed the capability of the most active compound (compound 5) to induce cell cycle arrest at Pre-G1 and G2/M phases as well as apoptosis.	Propidium	65-81	annexin A5	Homo sapiens	50-59
34515014-6	2022	The mechanism of cell death was determined using the Annexin V-FITC/ propidium iodide staining flow cytometry method.	Propidium	69-85	annexin A5	Homo sapiens	53-62
34233751-16	2021	Finally, TEX41 expression seems to be critical for leukemic proliferation, indeed, silencing experiments targeting TEX41 mRNA in the RS4;11 cell line hampered in vitro cell growth and cell cycle progression, by inducing G2-M arrest as confirmed propidium iodide staining and by the upregulation of p53 and p21 proteins.	Propidium	245-261	testis expressed 41	Homo sapiens	115-120
34209790-6	2021	Furthermore, we demonstrated the feasibility of the application of our multi-channel cell chip in various analysis methods through Annexin V-fluorescein isothiocyanate/propidium iodide staining, which is not used for conventional cell chips.	Propidium	168-184	annexin A5	Homo sapiens	131-140
34295778-4	2021	The effect of SOCS3 overexpression or knockdown on the proliferation and apoptosis of IL-6 treated human cytotrophoblasts were determined by Cell Counting Kit-8 (CCK8) assay and Annexin-V/Propidium Iodide (PI) double-staining assay, respectively.	Propidium	188-204	interleukin 6	Homo sapiens	86-90
34218556-3	2021	The apoptosis and cell cycle arrest of OCI-LY3 and TMD8 cells were detected by flow cytometry with FITC annexin V/PI (propidium iodide) double staining and PI, respectively.	Propidium	118-134	annexin A5	Homo sapiens	104-113
34204234-6	2021	Here, we use structurally locked engineered XCL1 variants and Candida killing assays, adenylate kinase release assays, and propidium iodide uptake assays to demonstrate that both XCL1 folds kill Candida, but they do so via different mechanisms.	Propidium	123-139	X-C motif chemokine ligand 1	Homo sapiens	179-183
35203308-5	2022	The antiapoptotic effect of the anti-CCL8 mAb was also demonstrated by Annexin V/propidium iodide staining assay.	Propidium	81-97	C-C motif chemokine ligand 8	Homo sapiens	37-41
34071389-8	2021	Subsequently, Annexin V- fluorescein isothiocyanate (FITC)/propidium iodide analysis showed that nanocomposites induced late apoptosis in HepG2 cells.	Propidium	59-75	annexin A5	Homo sapiens	14-23
34188587-6	2021	Results: Annexin V-FITC/propidium iodide staining with flow cytometry showed increased ratios of early apoptosis and decreased survival following incubation with sera of EAE and progressive MS. Levels of platelet-derived growth factor-BB were identical in serum and cerebrospinal fluids of patients with different forms of MS.	Propidium	24-40	annexin A5	Homo sapiens	9-18
35597169-5	2022	The effects of methyltransferase-like 14 (METTL14) on trophoblasts were evaluated using cell counting kit-8, transwell invasion assay, autophagic flux assay, and Annexin V/propidium iodide apoptosis assay.	Propidium	172-188	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	15-40
35559263-5	2022	The inverted microscope was used to analyze morphological changes, trypan blue exclusion assay for viability, and Annexin V-fluorescein isothiocyanate (FITC)-propidium iodide (PI) for cell death mechanisms.	Propidium	158-174	annexin A5	Homo sapiens	114-123
35182545-8	2022	Direct stimulation of RCMs and H9c2 cells with recombinant rat IL-1beta increased the p-GSK-3beta/GSK-3beta and Bax/Bcl-2 ratios and the expression of caspase-3 and N-GSDMD, while both SB216763 and TLR1 (an IL-1beta receptor inhibitor) markedly reduced these effects, as assessed using propidium iodide positive staining and the lactate dehydrogenase release assay.	Propidium	286-302	interleukin 1 alpha	Rattus norvegicus	63-71
35447911-3	2022	OBA-RT exerted cytotoxic effects with a half-maximal inhibitory concentration of approximately 7 microM and mediated apoptosis as detected by annexin V/propidium iodide using flow cytometry and nuclear staining assays.	Propidium	152-168	annexin A5	Homo sapiens	142-151
34066415-5	2021	Plasma membrane integrity was compromised in 2H-11 and HUVEC, as determined by an increase in propidium iodide staining, which was preceded by Ca2+ flux.	Propidium	94-110	H1.1 linker histone, cluster member	Homo sapiens	46-50
35601150-4	2022	High TRIP13 expression induced NDP resistance to ESCC based on the cell proliferation promoting/inhibition rate and cell migration promoting/inhibition rate analysis, flow cytometry assay of apoptotic subpopulations with a combination of Annexin V-FITC and propidium iodide, and Western blot analysis downregulating cleaved PARP, gammaH2A.X, cleaved caspase-3, and Bax and upregulating Bcl-2 expression.	Propidium	257-273	thyroid hormone receptor interactor 13	Homo sapiens	5-11
35302175-4	2022	The effect of Sig-1R overexpression on cell proliferation detected by EdU staining, cell cycle progression by propidium iodide (PI), apoptosis by Annexin V-APC/PI, mitochondrial membrane potential by Mitolite Red and cytoplasmic Ca2+ levelsby Fura-2/AM in islet beta-cells were measured by flow cytometry.	Propidium	110-126	sigma non-opioid intracellular receptor 1	Mus musculus	14-20
35160583-7	2022	In addition, the cytotoxicity and cell membrane damage of Nisin Z were evaluated by using the MTT and LDH assay, which was complemented via Annexin-V/ Propidium Iodide (PI) by using flowcytometry.	Propidium	151-167	annexin A5	Homo sapiens	140-149
34873073-7	2022	The annexin V/propidium iodide double staining assay revealed that LCH induced apoptosis, and the LCH-induced apoptosis was accompanied by cell cycle arrest in the G1 phase.	Propidium	14-30	LCH	Homo sapiens	67-70
34990135-8	2022	Apoptotic cell death was evidenced from the Annexin-V/fluorescein isothiocyanate (FITC)/propidium iodide (PI) assay and green fluorescence in red light in the Fluo-4 AM assay due to ER stress, and mitochondrial dysfunction was evidenced from the 5,5,6,6"-tetrachloro-1,1",3,3"-tetraethylbenzimidazolylcarbocyanine iodide (JC-1) assay in A549 cells.	Propidium	88-104	annexin A5	Homo sapiens	44-53
34873073-7	2022	The annexin V/propidium iodide double staining assay revealed that LCH induced apoptosis, and the LCH-induced apoptosis was accompanied by cell cycle arrest in the G1 phase.	Propidium	14-30	LCH	Homo sapiens	98-101
2642893-1	1989	We have analyzed c-myc protein expression during the cell cycle in malignant B-cell lymphomas by dual flow cytometric detection of a fluoresceinated polyclonal anti-myc antibody and propidium iodide which binds stochiometrically to DNA.	Propidium	182-198	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	17-22
2478022-10	1989	However, NF-H, NF-M, and NF-L were expressed throughout the cell cycle in dual parameter studies of D283 cells labeled with an antibody and propidium iodide.	Propidium	140-156	neurofilament heavy chain	Homo sapiens	9-13
2478022-10	1989	However, NF-H, NF-M, and NF-L were expressed throughout the cell cycle in dual parameter studies of D283 cells labeled with an antibody and propidium iodide.	Propidium	140-156	neurofilament light chain	Homo sapiens	25-29
2654494-3	1989	In seven patients studied, GM-CSF increased the fraction of myeloid leukemic blasts in S phase as measured by propidium iodide DNA staining, bromodeoxyuridine incorporation, or ARA-C suicide techniques.	Propidium	110-126	colony stimulating factor 2	Homo sapiens	27-33
2642893-1	1989	We have analyzed c-myc protein expression during the cell cycle in malignant B-cell lymphomas by dual flow cytometric detection of a fluoresceinated polyclonal anti-myc antibody and propidium iodide which binds stochiometrically to DNA.	Propidium	182-198	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	19-22
2850959-3	1988	The hybrid nature of HY2-15 was confirmed by DNA histograms using propidium iodide and flow cytometry.	Propidium	66-82	RNA, Ro60-associated Y3	Homo sapiens	21-27
3683365-1	1987	Propidium iodide, an antitumor compound, was diffused into crystals of a complex between RNase A and deoxytetraadenylate (dpA)4).	Propidium	0-16	ribonuclease A family member 1, pancreatic	Homo sapiens	89-96
3414778-3	1988	A single-step propidium iodide exclusion assay was then used to show that EPO + MBP in the absence of hydrogen peroxide is substantially cytotoxic only to the acute lymphocytic leukemia and IM-9 cells.	Propidium	14-30	eosinophil peroxidase	Homo sapiens	74-77
3414778-3	1988	A single-step propidium iodide exclusion assay was then used to show that EPO + MBP in the absence of hydrogen peroxide is substantially cytotoxic only to the acute lymphocytic leukemia and IM-9 cells.	Propidium	14-30	myelin basic protein	Homo sapiens	80-83
3890740-1	1985	Flow cytometry, using fluorescein-bound specific antibodies and propidium iodide, was shown to be effective in detecting Legionella spp.	Propidium	64-80	histocompatibility minor 13	Homo sapiens	132-135
3442556-1	1987	The process of DNA digestion with DNase I was monitored in interphase chromatin of differentiated cells by flow cytometry after DNA staining with either the intercalating dye propidium iodide (PI) or the AT specific dye Hoechst 33258 (HO).	Propidium	175-191	deoxyribonuclease I	Mus musculus	34-41
3801422-3	1986	Low-temperature spectrophotometric binding measurements indicate that d(A-T)6 has a significantly larger binding constant for propidium than dA10.dT10, as with the analogous alternating and nonalternating DNA polymers.	Propidium	126-135	antennal protein 10	Drosophila melanogaster	141-145
3801422-3	1986	Low-temperature spectrophotometric binding measurements indicate that d(A-T)6 has a significantly larger binding constant for propidium than dA10.dT10, as with the analogous alternating and nonalternating DNA polymers.	Propidium	126-135	Actin 57B	Drosophila melanogaster	146-150
3801422-4	1986	The oligomer dA10.dT10 displays positive cooperativity in its propidium binding isotherm, and its binding constant increases with increasing temperature while d(A-T)6 does not display positive cooperativity, and its binding constant decreases with temperature, again as with the analogous polymers.	Propidium	62-71	antennal protein 10	Drosophila melanogaster	13-17
3801422-4	1986	The oligomer dA10.dT10 displays positive cooperativity in its propidium binding isotherm, and its binding constant increases with increasing temperature while d(A-T)6 does not display positive cooperativity, and its binding constant decreases with temperature, again as with the analogous polymers.	Propidium	62-71	Actin 57B	Drosophila melanogaster	18-22
4092697-2	1985	The intercalating agents ethidium bromide (EtBr) and propidium iodide induce the specific release of high mobility group proteins HMG 14 and HMG 17 under low ionic strength conditions.	Propidium	53-69	high mobility group nucleosome binding domain 1	Gallus gallus	130-136
4092697-2	1985	The intercalating agents ethidium bromide (EtBr) and propidium iodide induce the specific release of high mobility group proteins HMG 14 and HMG 17 under low ionic strength conditions.	Propidium	53-69	high mobility group nucleosomal binding domain 4	Gallus gallus	141-147
1125207-2	1975	A bis-quaternary fluorescence probe, propidium diiodide, has been found to exhibit a tenfold enhancement of fluorescence when bound to acetylcholinesterase from Torpedo california.	Propidium	37-55	acetylcholinesterase (Cartwright blood group)	Homo sapiens	135-155
6391869-6	1984	Propidium iodide prevents anti-H2B from binding to chromosomes, and therefore must be added only after antibody labeling is completed.	Propidium	0-16	H2B clustered histone 21	Homo sapiens	31-34
6530667-14	1984	Fasciculin binds to the peripheral anionic site, since it can displace propidium, a probe for that site, from acetylcholinesterase.	Propidium	71-80	acetylcholinesterase	Mus musculus	110-130
6278141-1	1981	Epstein-Barr virus (EBV) receptor positive cells absorbed FITC-conjugated virions and were subsequently stained for DNA content with propidium iodide.	Propidium	133-149	complement C3d receptor 2	Homo sapiens	0-33
922007-1	1977	The interactions of a quinacrine derivative, methylated at both the aromatic and aliphatic nitrogens, and propidium diiodide with the dinucleoside monophosphates CpG, GpC, UpA and ApU have been investigated using 13C-NMR (for the quinacrine derivative prepared with [13C]methyl substituents and 1H-NMR and ultraviolet-visible spectroscopy.	Propidium	106-124	glycophorin C (Gerbich blood group)	Homo sapiens	167-170
922007-1	1977	The interactions of a quinacrine derivative, methylated at both the aromatic and aliphatic nitrogens, and propidium diiodide with the dinucleoside monophosphates CpG, GpC, UpA and ApU have been investigated using 13C-NMR (for the quinacrine derivative prepared with [13C]methyl substituents and 1H-NMR and ultraviolet-visible spectroscopy.	Propidium	106-124	proline rich acidic protein 1	Homo sapiens	172-175
922007-4	1977	At higher concentrations UpA and GpC gave similar spectral changes indicating that they could also form significant amounts of an intercalated complex with propidium under appropriate conditions.	Propidium	156-165	proline rich acidic protein 1	Homo sapiens	25-28
922007-4	1977	At higher concentrations UpA and GpC gave similar spectral changes indicating that they could also form significant amounts of an intercalated complex with propidium under appropriate conditions.	Propidium	156-165	glycophorin C (Gerbich blood group)	Homo sapiens	33-36
1125207-13	1975	Although propidium and edrophonium associate at separate sites on acetylcholinesterase, bis-quaternary ligands where the quaternary nitrogens are separated by 14 A displace both ligands from the enzyme with equal effectiveness.	Propidium	9-18	acetylcholinesterase (Cartwright blood group)	Homo sapiens	66-86
33895604-7	2021	Importantly, increased Treg cells numbers by TRP-1 correlated with improved CD4 + CD25 + FOXP3 + expression in vitro, while propidium iodide-based staining showed low TRP-1-induced cytotoxicity.	Propidium	124-140	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	167-172
33417255-5	2021	Using Annexin V/propidium iodide staining, a significant increase in apoptosis was found after chrysophanol treatment on HeLa cells, and this process was mediated by caspases 3/7 with a clear inactivation of the antiapoptotic Bcl-2 family protein.	Propidium	16-32	caspase 3	Homo sapiens	166-178
33415682-9	2021	To test for neuronal viability after hypoxia, propidium iodide staining revealed significant neuroprotection of hippocampal CA1 pyramidal neurons when pretreated with Tat-GluA2-3Y peptide, CK2 inhibitors, dynamin inhibitor, CP-AMPAR antagonists (applied 5 min after hypoxia), and perampanel (either at 5 min hypoxia onset or during APSP).	Propidium	46-62	tyrosine aminotransferase	Rattus norvegicus	167-170
33960240-5	2021	Apoptosis induction by expression of DFF40 was evaluated using Annexin-V/propidium iodide staining.	Propidium	73-89	DNA fragmentation factor, beta subunit	Mus musculus	37-42
34031851-9	2021	Increased G1-phase and decreased S-phase cell population were induced by HIF-2alpha siRNA based on the determination of cell cycle distribution using propidium iodide staining.	Propidium	150-166	endothelial PAS domain protein 1	Homo sapiens	73-83
34029971-7	2021	In agreement with analysis of inhibition kinetics and molecular modeling studies, the lead compounds were found to bind effectively to the peripheral anionic site of AChE and displace propidium, indicating their potential to block AChE-induced beta-amyloid aggregation.	Propidium	184-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	166-170
34029971-7	2021	In agreement with analysis of inhibition kinetics and molecular modeling studies, the lead compounds were found to bind effectively to the peripheral anionic site of AChE and displace propidium, indicating their potential to block AChE-induced beta-amyloid aggregation.	Propidium	184-193	acetylcholinesterase (Cartwright blood group)	Homo sapiens	231-235
33837090-6	2021	The FOXO3 ubiquitination and changes in cell biological behaviors were detected using immunoprecipitation, MTT, and Annexin V/propidium iodide assays.	Propidium	126-142	forkhead box O3	Rattus norvegicus	4-9
33847044-6	2021	Flow cytometry using propidium iodide and the annexin V marker demonstrated minimal toxicity in normal human astrocytes for a promising candidate molecule DC10 .	Propidium	21-37	F-box protein 8	Homo sapiens	155-159
33926212-5	2021	Specifically, the role of a specific caspase was identified by recovery rate, relative proliferation rate, Annexin V/propidium iodide co-staining, and caspase activity using its inhibitor and activator.	Propidium	117-133	caspase 8	Mus musculus	37-44
33415682-9	2021	To test for neuronal viability after hypoxia, propidium iodide staining revealed significant neuroprotection of hippocampal CA1 pyramidal neurons when pretreated with Tat-GluA2-3Y peptide, CK2 inhibitors, dynamin inhibitor, CP-AMPAR antagonists (applied 5 min after hypoxia), and perampanel (either at 5 min hypoxia onset or during APSP).	Propidium	46-62	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	171-176
33669837-4	2021	By measuring the cell retention of fluorescein-linked annexin V and propidium iodide, we showed an apoptotic mode of death for MOLM-13 cells after treatment with either DAC or AZA, for MOLM-13/DAC cells after treatment with AZA, and for MOLM-13/AZA cells after treatment with DAC.	Propidium	68-84	arylacetamide deacetylase	Homo sapiens	169-172
33576886-8	2021	Peptides immediately interacted with C. albicans cell surfaces, as indicated by fluorescence live cell imaging analyses, and induced severe membrane damage, as indicated by propidium iodide uptake induced upon treatment of C. albicans cells with ApoB-derived peptides.	Propidium	173-189	apolipoprotein B	Homo sapiens	246-250
33754583-7	2021	Flow cytometry-Annexin V/propidium iodide (PI) staining and CCK-8 assay confirmed that the high-, medium- and low-dose EPO inhibited the apoptosis of RGCs induced by high glucose in a dose-dependent manner (P<0.05).	Propidium	25-41	erythropoietin	Rattus norvegicus	119-122
33302912-10	2020	Treatment with exogenous Sema3A in quantitative BrdU, cell cycle, and propidium iodide labeling assays demonstrated that Sema3A significantly inhibited BTSC proliferation without inducing cell death.	Propidium	70-86	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	25-31
32985771-5	2021	Cultivation at 40 C was demonstrated to lead to higher plasma membrane permeabilization of a pdr18Delta cell population with the PDR18 gene deleted compared with the parental strain population, as indicated by flow cytometry analysis of propidium iodide stained cells.	Propidium	237-253	ATP-binding cassette multidrug transporter PDR18	Saccharomyces cerevisiae S288C	129-134
33372676-7	2021	The number of Beclin-1/propidium iodide-positive cells was significantly less in the LV-shRTN1-C group than in the LV-shNC group.	Propidium	23-39	beclin 1	Rattus norvegicus	14-22
32826883-5	2020	siRNA-mediated knock down of Neat1 reduced apoptosis and necrosis in murine cardiomyocytes (CM) and human iPS-derived CMs in response to prolonged hypoxia and hypoxia-reoxygenation, assessed with Annexin V/propidium iodide-staining, a Caspase 3/7 activity assay, LDH release, and western blot for cleaved Caspase 3.	Propidium	206-222	nuclear paraspeckle assembly transcript 1 (non-protein coding)	Mus musculus	29-34
33425096-5	2020	After constructing cell lines with a knocked down KLHL14 gene, we used the MTT assay, flow cytometry with propidium iodide (PI), Annexin V-FITC/PI, and transwell assay and found that knockdown of KLHL14 gene inhibited proliferation of A-2780 cells, caused cell G0/G1 phase arrest, promoted apoptosis, and inhibited migration and invasiveness.	Propidium	106-122	kelch like family member 14	Homo sapiens	50-56
33293832-6	2020	The efficacy of knockdown of ADORA1 sensitizes to chemotherapy was assessed by staining with Annexin V/propidium iodide followed with flow cytometry and nuclei fragmentation.	Propidium	103-119	adenosine A1 receptor	Mus musculus	29-35
33133573-8	2020	Annexin V-fluorescein isothiocyanate (FITC) propidium iodide (PI) staining assay revealed that apoptosis significantly increased in both breast cancer cell types after LHE treatment.	Propidium	44-60	annexin A5	Homo sapiens	0-9
32382956-8	2020	Activation of caspase-3, indicative of apoptosis, was seen both for cathinones and METH, and confirmed by annexin V and propidium iodide positive staining.	Propidium	120-136	caspase 3	Homo sapiens	14-23
32459682-5	2020	In the laser confocal microscope and plate reader analyses, apoptosis, mitochondrial membrane depolarization (JC-1), cell death (propidium iodide/Hoechst rate), and ROS-level production increased by activating TRPV1 in the cells using the OXAL treatment, although the cell viability values decreased.	Propidium	129-145	transient receptor potential cation channel subfamily V member 1	Homo sapiens	210-215
32108953-6	2020	IL-1beta/TNF death was necrosis by trypan blue and propidium iodide positivity, absence of mitochondrial death pathway and caspase activation, and failure of a caspase inhibitor or necrostatin-1s to prevent death.	Propidium	51-67	interleukin 1 alpha	Mus musculus	0-8
32108953-6	2020	IL-1beta/TNF death was necrosis by trypan blue and propidium iodide positivity, absence of mitochondrial death pathway and caspase activation, and failure of a caspase inhibitor or necrostatin-1s to prevent death.	Propidium	51-67	tumor necrosis factor	Mus musculus	9-12
32642922-5	2021	2 microM Li2CO3 promoted a significant reduction in propidium iodide uptake in the CA2 area of hippocampus, whereas 20 microM promoted neuroprotection in the CA3 and GrDG areas.	Propidium	52-68	carbonic anhydrase 2	Mus musculus	83-86
31721529-8	2020	Propidium iodide flow cytometry was used to determine cell cycle progression in HEK293T and HCT116 cells under hsa-miR-587 (miR-587) overexpression circumstances.	Propidium	0-16	microRNA 587	Homo sapiens	111-122
31721529-8	2020	Propidium iodide flow cytometry was used to determine cell cycle progression in HEK293T and HCT116 cells under hsa-miR-587 (miR-587) overexpression circumstances.	Propidium	0-16	microRNA 587	Homo sapiens	115-122
32555132-6	2020	In addition, CQ or Baf stimulation enhances G1 arrest in TGF-ss treated HK-2 cells, as investigated using propidium iodide (PI) staining and flow cytometry, which was further confirmed by a decrease in the expression of phosphorylated retinoblastoma protein (p-RB) and cyclin-dependent kinase 4 (CDK4).	Propidium	106-122	BAF nuclear assembly factor 1	Homo sapiens	19-22
32606957-11	2020	Activation of apoptosis/necrosis was confirmed by annexin V/propidium iodide double staining, which showed increasing levels of active caspase 3, cleaved poly(ADP-ribose) polymerase and the RIP1-RIP3-MLKL complex.	Propidium	60-76	caspase 3	Homo sapiens	135-144
32606957-11	2020	Activation of apoptosis/necrosis was confirmed by annexin V/propidium iodide double staining, which showed increasing levels of active caspase 3, cleaved poly(ADP-ribose) polymerase and the RIP1-RIP3-MLKL complex.	Propidium	60-76	poly(ADP-ribose) polymerase 1	Homo sapiens	154-181
32606957-11	2020	Activation of apoptosis/necrosis was confirmed by annexin V/propidium iodide double staining, which showed increasing levels of active caspase 3, cleaved poly(ADP-ribose) polymerase and the RIP1-RIP3-MLKL complex.	Propidium	60-76	receptor interacting serine/threonine kinase 1	Homo sapiens	190-194
31898360-9	2020	Moreover, overexpressing GATA4-miR1 in SW480 and PC3 cells resulted in a significant increase of the sub-G1 population in both cell lines, as detected by propidium iodide flow cytometry.	Propidium	154-170	GATA binding protein 4	Homo sapiens	25-30
31898360-9	2020	Moreover, overexpressing GATA4-miR1 in SW480 and PC3 cells resulted in a significant increase of the sub-G1 population in both cell lines, as detected by propidium iodide flow cytometry.	Propidium	154-170	fibronectin type III and SPRY domain containing 1	Homo sapiens	31-35
32495168-4	2020	Fluorescence of active caspases 3 and 7 and changes in nuclear DNA in cells in the presence of CyAm were detected by using fluorochrome-labeled inhibitor of caspases (FLICA) and Hoechst and propidium iodide reagents.	Propidium	190-206	caspase 3	Homo sapiens	23-39
32443594-6	2020	Eosinophils adhesion to hTERT airway smooth muscle (ASM) cells was measured by evaluating their peroxidase activity and viability by annexin V and propidium iodide staining.	Propidium	147-163	telomerase reverse transcriptase	Homo sapiens	24-29
32443594-6	2020	Eosinophils adhesion to hTERT airway smooth muscle (ASM) cells was measured by evaluating their peroxidase activity and viability by annexin V and propidium iodide staining.	Propidium	147-163	H19 imprinted maternally expressed transcript	Homo sapiens	52-55
32424160-8	2020	DNAJB6 KO cells displayed an increased rate of cell death as assessed by trypan blue exclusion and propidium iodide (PI) uptake assays.	Propidium	99-115	DnaJ heat shock protein family (Hsp40) member B6	Homo sapiens	0-6
31498070-14	2020	FITC Annexin V and propidium iodide apoptosis assay verified that IL-34 down-regulated cells induced massive apoptosis through apoptotic signalling caspase3, while IL-1beta treated cells presented termination of cellular apoptosis signalled by BCL-2.	Propidium	19-35	interleukin 34	Homo sapiens	66-71
32149762-6	2020	The survival of HK-2 cells was determined using 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) and Annexin V-Light 650/propidium iodide (PI) assays.	Propidium	141-157	hexokinase 2	Homo sapiens	16-20
31719251-6	2020	After pre-treatment with RIP3 inhibitor GSK"872, propidium iodide staining and lactate dehydrogenase release detection showed that neuronal necrosis rate was significantly decreased; RIP3 and MLKL protein expression significantly decreased.	Propidium	49-65	receptor interacting serine/threonine kinase 3	Homo sapiens	25-29
32006234-10	2020	The anti-NSE antibody incorporated propidium iodide into neurons through the disrupted plasma membrane, which are not observed in ferroptosis and autophagic cell death.	Propidium	35-51	enolase 2	Homo sapiens	9-12
32143618-7	2020	Test of the ability of CDD to induce early signs of apoptosis was validated by annexin V/propidium iodide assay using FACS analysis.	Propidium	89-105	natriuretic peptide A	Homo sapiens	23-26
31985234-10	2020	Propidium iodine staining suggested that the decrease in NO and increase in ROS in ALDH6A1-O/E cells could be caused by depolarization of the mitochondrial membrane potential (DeltaPsi).	Propidium	0-16	aldehyde dehydrogenase 6 family member A1	Homo sapiens	83-90
32111733-6	2020	Interestingly, we establish an in vivo propidium iodide-staining method and reveal that the caspy2-GSDMEb signaling cascade is essential for enhancing renal tubular damage during lethal LPS-induced septic shock, whereas administration of the zebrafish-specific GSDMEb-derived peptide inhibitor Ac-FEID-CMK can attenuate mortality and septic AKI in vivo.	Propidium	39-55	caspase b	Danio rerio	92-98
32307944-4	2020	Apoptosis and protein expression of caspases were assessed using propidium iodide staining and Western blot analysis, respectively.	Propidium	65-81	caspase 9	Homo sapiens	36-44
31894528-10	2020	Additionally, annexin V, FITC, and propidium iodide flow cytometry showed overexpression of miR-9119-induced apoptosis.	Propidium	35-51	microRNA 9119	Equus caballus	92-100
32521855-12	2020	Annexin V/propidium iodide (PI) showed a significant increase in the apoptotic SK-BR-3 cells.	Propidium	10-26	annexin A5	Homo sapiens	0-9
32111333-9	2020	The F2 fraction at 0.5 wt.% was also shown to be capable of inducing weak early apoptosis, which could be measured by using the Fluorescein isothiocyanate Annexin V Apoptosis Detection Kit with Propidium Iodide Solution.	Propidium	194-210	annexin A5	Gallus gallus	155-164
31837976-3	2020	Uptake of the cationic fluorescent dye propidium iodide (PI) was significantly increased in Px1/P2RX7/HEK293 cells compared to that in mock cells, whereas there was no significant uptake of the anionic fluorescent dye sulforhodamine 101 (SR101).	Propidium	39-55	pannexin 1	Homo sapiens	92-95
31837976-3	2020	Uptake of the cationic fluorescent dye propidium iodide (PI) was significantly increased in Px1/P2RX7/HEK293 cells compared to that in mock cells, whereas there was no significant uptake of the anionic fluorescent dye sulforhodamine 101 (SR101).	Propidium	39-55	purinergic receptor P2X 7	Homo sapiens	96-101
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	cyclin D1	Homo sapiens	59-64
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	microRNA 519d	Homo sapiens	68-76
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	microRNA 519d	Homo sapiens	135-143
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	cyclin D1	Homo sapiens	166-171
31661371-8	2020	Taken together, these data demonstrate that suppression of CCND1 by miR-519d-3p might be a therapeutic target for glioma.Abbreviations miR-519d-3p: microRNA-519d-3p; CCND1: Cyclin D1; ATCC: American Type Culture Collection; MTT: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide; PI: propidium iodide; WT: wild type; MUT: mutant type; SD: standard deviation.	Propidium	297-313	cyclin D1	Homo sapiens	173-182
31735356-3	2020	They were also effective at displacing propidium from the peripheral anionic site (PAS) of acetylcholinesterase (AChE), suggesting that they could block AChE-induced beta-amyloid aggregation.	Propidium	39-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	91-111
31887472-5	2020	Compounds 6j and 6k elicited significant displacement of propidium iodide from PAS-AChE, excellent BBB permeability in PAMPA assay, and anti-Abeta aggregatory activity in self- and AChE-induced experiments with neuroprotective activity towards neuroblastoma SH-SY5Y cells.	Propidium	57-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
31897093-9	2020	Furthermore, Annexin V-fluorescein isothiocyanate/propidium iodide flow cytometry indicated that the silencing of Rac1 restored the pro-apoptotic DPSC cell number with miR-224 transfection.	Propidium	50-66	Rac family small GTPase 1	Homo sapiens	114-118
31605630-3	2020	In this study, the results of the MTT assay, colony formation, and propidium iodide (PI) staining with flow cytometry revealed that melatonin dose dependently inhibited epidermal growth factor (EGF)-induced proliferation of human ARPE-19 cells.	Propidium	67-83	epidermal growth factor	Homo sapiens	169-192
31735356-3	2020	They were also effective at displacing propidium from the peripheral anionic site (PAS) of acetylcholinesterase (AChE), suggesting that they could block AChE-induced beta-amyloid aggregation.	Propidium	39-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	113-117
31735356-3	2020	They were also effective at displacing propidium from the peripheral anionic site (PAS) of acetylcholinesterase (AChE), suggesting that they could block AChE-induced beta-amyloid aggregation.	Propidium	39-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157
31765429-9	2019	After in vitro treatment for five days with 6.25 muM NJ05 or NJ07 separately, we observed a decrease of 30% in schistosomula viability, whilst treatment with NJ05+NJ07 lead to a reduction of 75% in viability measured by ATP quantitation and propidium iodide labeling.	Propidium	241-257	latexin	Homo sapiens	49-52
31561043-6	2019	Also, 48 and 49 showed significant displacement of propidium iodide from the peripheral anionic site (PAS) of hAChE, excellent blood-brain barrier (BBB) permeability in parallel artificial membrane permeation assay (PAMPA), and neuroprotective ability against SH-SY5Y neuroblastoma cell lines.	Propidium	51-67	acetylcholinesterase (Cartwright blood group)	Homo sapiens	110-115
31788043-10	2019	MTT and Annexin V-fluorescein isothiocyanate/propidium iodide assays demonstrated that CLDN1 silencing significantly inhibits proliferation and enhances apoptosis induced by 5-FU treatment in Hep/5FU cells, compared with non-silenced Hep/5FU cells.	Propidium	45-61	claudin 1	Homo sapiens	87-92
31371049-9	2019	The ESC apoptosis was assessed by annexin V/propidium iodide detection using flow cytometry.	Propidium	44-60	extra sexcombs	Drosophila melanogaster	4-7
31711531-10	2019	An Annexin V Apoptosis Detection Kit with propidium iodide was used to detect apoptosis.	Propidium	42-58	annexin A5	Mus musculus	3-12
31611559-8	2019	In vitro, exposure of human umbilical vein endothelial cells (HUVECs) to KD sera-treated THP1 cells resulted in the activation of NLRP3 inflammasome and subsequent pyroptosis induction, as evidenced by elevated expression of caspase-1, GSDMD, cleaved p30 form of GSDMD, IL-1beta and IL-18, and increased LDH release and TUNEL and propidium iodide (PI)-positive cells.	Propidium	330-346	NLR family pyrin domain containing 3	Homo sapiens	130-135
31724835-10	2019	Selective inhibition of COX-2 by celecoxib dramatically decreased PAEC death in vitro and in vivo as defined by propidium iodide (PI)-Annexin V staining.	Propidium	112-128	prostaglandin-endoperoxide synthase 2	Sus scrofa	24-29
31491074-3	2019	The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE.	Propidium	130-146	acetylcholinesterase (Cartwright blood group)	Homo sapiens	183-188
31291545-8	2019	Importantly, DRP1 knockdown decreased cell death as indicated by the reduced number of propidium iodide-positive cells and the cleavage of caspase-3 and poly (ADP-ribose) polymerase.	Propidium	87-103	dynamin 1-like	Rattus norvegicus	13-17
31030940-9	2019	Specifically, APN reduced propidium-iodide-positive cells, NLRP3 inflammasomes, apoptosis-related speck-like protein containing caspase recruitment domains, and pro-inflammation factors IL-1beta and IL-18, all of which was reversed by overexpression of FoxO4.	Propidium	26-42	adiponectin, C1Q and collagen domain containing	Homo sapiens	14-17
31474749-9	2019	Lack of DJ-1 sensitized cells to apoptosis induced by H2O2 as detected using Annexin V and propidium iodide by flow cytometry analysis.	Propidium	91-107	Parkinsonism associated deglycase	Homo sapiens	8-12
31271946-6	2019	Compounds 44 and 67 produced significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE.	Propidium	57-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	116-120
31336786-5	2019	Treatment of DMC led to the apoptosis of PANC-1 by caspase-3 activation as revealed by annexin-V/propidium iodide double-staining.	Propidium	97-113	caspase 3	Homo sapiens	51-60
30623407-5	2019	The increase in Bcl2/Bax ratio increased the cell metabolic activity and decreased propidium iodide-positive cells.	Propidium	83-99	BCL2 apoptosis regulator	Homo sapiens	16-20
30623407-5	2019	The increase in Bcl2/Bax ratio increased the cell metabolic activity and decreased propidium iodide-positive cells.	Propidium	83-99	BCL2 associated X, apoptosis regulator	Homo sapiens	21-24
31258779-6	2019	According to the results of Annexin V-FITC/propidium iodide (PI) staining-based fluorescence activated cell sorting (FACS) analysis, knockdown of CBX2 increased HCC cell apoptosis.	Propidium	43-59	chromobox 2	Homo sapiens	146-150
30896802-3	2019	Liver cancer cells were resistant to TNFSF10; however, EFLDO increased TNFSF10-induced cancer cell viability inhibition and cell apoptosis induction as assessed by MTT assay and Annexin V-fluorescein isothiocyanate (FITC)/propidium iodide assay, respectively.	Propidium	222-238	TNF superfamily member 10	Homo sapiens	71-78
30614043-5	2019	Pyroptosis was also determined by lactate dehydrogenase release and active caspase-1-propidium iodide double staining.	Propidium	85-101	caspase 1	Homo sapiens	75-84
30896849-6	2019	Additionally, Annexin V-fluorescein isothiocyanate/propidium iodide double staining and flow cytometry were used to evaluate the cell apoptosis, and overexpression of miR-29b increased cell apoptosis rates in AST-treated LX-2 cells; however, silencing of it had the opposite effect.	Propidium	51-67	microRNA 29b-1	Homo sapiens	167-174
30761646-5	2019	Annexin V/Propidium Iodide assay demonstrated decrease in the mechanisms of apoptosis in infected cells after incubation of IL-24 neutralizing antibody.	Propidium	10-26	annexin A5	Homo sapiens	0-9
30761646-5	2019	Annexin V/Propidium Iodide assay demonstrated decrease in the mechanisms of apoptosis in infected cells after incubation of IL-24 neutralizing antibody.	Propidium	10-26	interleukin 24	Homo sapiens	124-129
30605887-3	2019	Compound 6g also exhibited significant displacement of propidium iodide from the peripheral anionic site (PAS) of AChE (22.22 +- 1.11%) and showed good CNS permeability in PAMPA-BBB assay (Pe(exp), 6.93 +- 0.46).	Propidium	55-71	acetylcholinesterase	Mus musculus	114-118
30862357-6	2019	TRAIL-induced apoptosis in HeLa cells was evaluated by the gammaH2AX foci formation assay to check for double-strand break and propidium iodide and Annexin V staining to quantify apoptotic cells.	Propidium	127-143	TNF superfamily member 10	Homo sapiens	0-5
30183374-9	2019	Moreover, the elevation of S100A16 in SCLC cells prevented the loss of mitochondrial membrane potential (Deltapsim) and enhanced resistance to apoptosis under stressful conditions, which were determined by Annexin V/propidium iodide and JC-1 assay.	Propidium	216-232	S100 calcium binding protein A16	Homo sapiens	27-34
30778617-3	2019	CD151 ablation sensitized multiple tumor cell types to several anti-cancer drugs (e.g., gefitinib and camptothecin), thus increasing apoptosis, as seen using cleaved caspase-3, cleaved PARP (poly (ADP-ribose) polymerase), annexin V, and propidium iodide staining assays.	Propidium	237-253	CD151 molecule (Raph blood group)	Homo sapiens	0-5
30304557-8	2019	Annexin-V propidium iodide flow cytometry was used to examine the cell apoptosis, and transwell assay was used to investigate the effects of lncRNA PVT1 on cell migration.	Propidium	10-26	annexin A5	Homo sapiens	0-9
30675309-6	2019	Beclin 1 induced G2 arrest of HCT-15 transfectants as determined using propidium iodide staining (P&lt;0.05), whereas HCT-116 transfectants were arrested in G1 phase (P&lt;0.05).	Propidium	71-87	beclin 1	Homo sapiens	0-8
30296564-10	2019	Cell Counting Kit-8 assay and AnnexinV/propidium iodide analyses showed that TCF21 overexpression sensitized SGC-7901 cells to cisplatin, whereas its depletion reduced sensitivity in BGC-823 cells.	Propidium	39-55	transcription factor 21	Homo sapiens	77-82
30602587-6	2019	Caspase-3 protein expression was also significantly decreased in U373MG cells indicating IDE-induced apoptosis that was confirmed by flow cytometric Annexin V/propidium iodide staining.	Propidium	159-175	caspase 3	Homo sapiens	0-9
30556397-4	2019	While [P][I] is a crystalline solid, propidium salts with [BETI] or [NTf2] counteranions, i.e., [P][BETI] and [P][NTf2], have significantly lower crystallinity as reflected in powder X-ray diffraction data.	Propidium	37-46	nuclear transport factor 2	Homo sapiens	114-118
30563041-4	2018	Besides, peptide B11-induced apoptosis was confirmed by isothiocyanate-labeled Annexin V/propidium iodide (Annexin V-FITC/PI) double staining of HeLa cells.	Propidium	89-105	annexin A5	Homo sapiens	107-116
30657556-5	2019	The cell apoptosis and viability after inhibition or overexpression of microRNA-409 were evaluated by propidium iodide (PI) staining and cell counting kit-8 (CCK-8) assay.	Propidium	102-118	microRNA 409	Homo sapiens	71-83
30320347-3	2019	The present study examined the effects of LCH on cell proliferation, induction of apoptosis, and the regulation of matrin 3 (Matr3) protein in oral squamous cell carcinoma (OSCC) cells by Annexin V/propidium iodide (PI) staining and western blot analysis.	Propidium	198-214	matrin 3	Homo sapiens	115-123
30320347-3	2019	The present study examined the effects of LCH on cell proliferation, induction of apoptosis, and the regulation of matrin 3 (Matr3) protein in oral squamous cell carcinoma (OSCC) cells by Annexin V/propidium iodide (PI) staining and western blot analysis.	Propidium	198-214	matrin 3	Homo sapiens	125-130
30098501-7	2018	Propidium iodide (PI) uptake through large pores formed by pannexins and P2X7R was dose-dependently inhibited by extracellular zinc ions.	Propidium	0-16	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	73-78
30575921-5	2018	The effect of miR-410 on cell apoptosis was measured by Annexin V-fluorescein isothiocyanate 1 (FITC) and propidium iodide (PI).	Propidium	106-122	microRNA 410	Homo sapiens	14-21
30322800-4	2018	Treatment with ouabain, a Na+, K+-ATPase inhibitor, increased the ratio of propidium iodide-positive cells among NeuN-positive cells in the hippocampal CA1 region, which was prevented by MK-801 and d-AP5, specific blockers of the N-methyl-d-aspartate (NMDA) receptor.	Propidium	75-91	carbonic anhydrase 1	Rattus norvegicus	152-155
29761838-4	2018	Depletion of TOP2A in HCT116 and SW480 colon cancer cells by transfection of specific small interfering RNA significantly suppressed proliferation and inhibited invasion of cells, even induced apoptosis as indicated by both MTT assay, Annexin V/propidium iodide staining, and Transwell assay.	Propidium	245-261	DNA topoisomerase II alpha	Homo sapiens	13-18
30405817-4	2018	The results revealed that mild hyperthermia (at 42 C) effectively increased the inhibitory effect of GEM on cell viability, as determined using an MTT assay, and increased the effect of GEM-induced apoptosis, as determined using an Annexin V-fluorescein isothiocyanate/propidium iodide assay, in PC SW1990 cells.	Propidium	269-285	annexin A5	Homo sapiens	232-241
30014921-18	2018	Inhibition of FAK enzyme led to a significant increase in the level of active caspase-3, compared to control (11.35 folds), accumulation of cells in pre-G1 phase and annexin-V and propidium iodide staining in addition to cell cycle arrest at G2/M phase indicating that cell death proceeded through an apoptotic mechanism.	Propidium	180-196	protein tyrosine kinase 2	Homo sapiens	14-17
30014921-18	2018	Inhibition of FAK enzyme led to a significant increase in the level of active caspase-3, compared to control (11.35 folds), accumulation of cells in pre-G1 phase and annexin-V and propidium iodide staining in addition to cell cycle arrest at G2/M phase indicating that cell death proceeded through an apoptotic mechanism.	Propidium	180-196	caspase 3	Homo sapiens	78-87
30214593-12	2018	Annexin V-fluorescein isothiocyanate/propidium iodide staining demonstrated that HMGB1 silencing enhanced the effects of carboplatin in inducing the apoptosis of SKOV3-Carb cells relative to HMGB1 non-silenced control cells.	Propidium	37-53	high mobility group box 1	Homo sapiens	81-86
29964331-4	2018	The combination of BIX-01294 and TRAIL decreased cell viability and led to an increase in the annexin V/propidium iodide-positive cell population, DNA fragmentation, and caspase activation.	Propidium	104-120	TNF superfamily member 10	Homo sapiens	33-38
29964331-4	2018	The combination of BIX-01294 and TRAIL decreased cell viability and led to an increase in the annexin V/propidium iodide-positive cell population, DNA fragmentation, and caspase activation.	Propidium	104-120	annexin A5	Homo sapiens	94-103
30195770-7	2018	Annexin V and propidium iodide (PI) staining and flow cytometry demonstrated that miR-663a inhibited early and late apoptosis of human SSCs.	Propidium	14-30	microRNA 663a	Homo sapiens	82-90
30249880-3	2018	Then, the effect of silenced AFP on cell proliferation was assessed by dimethylthiazolyl-2,5-diphenyl-tetrazolium bromide assay, and apoptosis assessment with Hoechst33258 and flow cytometry (double stain with fluorescein isothiocyanate/propidium iodide), the roles of AFP in the cell cycle regulation were assessed by flow cytometry.	Propidium	237-253	alpha fetoprotein	Homo sapiens	29-32
29778424-8	2018	NRAGE depletion also sensitized HGC-27 and MGC-803 cells to cisplatin, as shown by CCK-8 and Annexin V/propidium iodide analyses.	Propidium	103-119	MAGE family member D1	Homo sapiens	0-5
30128023-7	2018	The effects of miR-96 on chemosensitivity were assessed by a carboxyfluorescein succinimidyl ester/propidium iodide labeling assay, and its effects on proliferation were assessed by Cell Counting Kit-8 or EdU staining assays.	Propidium	99-115	microRNA 96	Homo sapiens	15-21
30066919-7	2018	In addition, TNFRSF14-induced apoptotic cells were identified using Annexin V-fluorescein isothiocyanate and propidium iodide staining.	Propidium	109-125	TNF receptor superfamily member 14	Homo sapiens	13-21
30460115-6	2018	Moreover, the knockdown of ACSL-4 by a specific shRNA inhibited erastin-induced ferroptosis in Kras mutant DLD-1 cells as assessed by propidium iodide staining and lipid reactive oxygen species measurement.	Propidium	134-150	acyl-CoA synthetase long chain family member 4	Homo sapiens	27-33
29967295-4	2018	Propidium iodide staining showed that HP overexpressing the APOL1 G1 or G2 variant exhibited a higher rate of necrosis when compared with those overexpressing the wild-type G0 counterpart.	Propidium	0-16	apolipoprotein L1	Homo sapiens	60-65
30135397-4	2018	The activity of CPE on Vero cells was demonstrated by the entry of propidium iodide (PI) in the cells.	Propidium	67-83	cpe	Clostridium perfringens	16-19
30135397-5	2018	The entry of propidium iodide caused by CPE was well correlated with the loss of cell viability monitored by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test.	Propidium	13-29	cpe	Clostridium perfringens	40-43
29583132-8	2018	After that the cytotoxic activity of the SWCNT-CA4 was evaluated by flow cytometry using annexin V/propidium iodide (PI) test.	Propidium	99-115	carbonic anhydrase 4	Homo sapiens	47-50
29771820-8	2018	LGI1-Ab+ IgG increased the number of propidium iodide positive neurons, reduced mitochondrial membrane potentials, upregulated caspase-3 and Bax mRNA expression levels and downregulated Bcl-2 mRNA expression levels of neurons.	Propidium	37-53	leucine-rich repeat LGI family, member 1	Mus musculus	0-4
30008942-13	2018	The results from the Annexin V/propidium iodide double staining apoptosis assay indicated that Napsin A overexpression enhanced gefitinib-induced apoptosis in A549-GFT cells.	Propidium	31-47	napsin A aspartic peptidase	Homo sapiens	95-103
29693157-5	2018	The overexpression of miR-221-3p enhanced the number of propidium iodide (PI)+ cells and the activity of LDH in H2O2-treated cells.	Propidium	56-72	microRNA 221	Rattus norvegicus	22-29
29749441-4	2018	The second aim was to evaluate the abilities of fludarabine (FDR) and mafosfamide (MFA; a metabolite of cyclophosphamide) to induce apoptosis of CD19-CAR-T cells via the use of Annexin V/propidium iodide double staining.	Propidium	187-203	CD19 molecule	Homo sapiens	145-149
30008820-5	2018	Annexin V/propidium iodide apoptosis and Hoechst staining assays revealed that treatment with ADRB2 antagonists induced apoptosis in HCC cells.	Propidium	10-26	adrenoceptor beta 2	Homo sapiens	94-99
30008820-6	2018	Additionally, cell cycle analysis using propidium iodide staining demonstrated that growth suppression was associated with G2/M phase cell cycle arrest by ADRB2 antagonism in HCC cells.	Propidium	40-56	adrenoceptor beta 2	Homo sapiens	155-160
30008835-6	2018	Furthermore, overexpression of miR-29c in cisplatin-resistant cancer cells was demonstrated to inhibit tumor cell proliferation and to promote apoptosis in vitro and in vivo, as well as restoring cisplatin chemosensitivity by using a cell counting assay, colony formation assay, Annexin V-fluorescein isothocyanate/propidium iodide apoptosis analysis, terminal deoxynucleotidyl transferase dUTP nick end labeling and xenograft tumors in nude mice.	Propidium	315-331	microRNA 29c	Mus musculus	31-38
29480936-9	2018	Consistently, with these results, CA3 pyramidal cells exhibited reduced propidium iodide uptake and caspase-3 activity in slices pretreated with BDNF and exposed to OGD-RP.	Propidium	72-88	carbonic anhydrase 3	Rattus norvegicus	34-37
29655615-10	2018	Annexin-V/Propidium Iodide staining method was performed to detect apoptosis and necrosis in the MDM cells.	Propidium	10-26	secreted LY6/PLAUR domain containing 1	Homo sapiens	97-100
29805688-3	2018	Propidium iodide staining analysis identified the cell cycle arrest of G1 phase and western blotting analysis demonstrated that the expression levels of cyclin D1, cyclin E2, cyclin A and cyclin B1 were decreased.	Propidium	0-16	cyclin D1	Homo sapiens	153-162
29805688-3	2018	Propidium iodide staining analysis identified the cell cycle arrest of G1 phase and western blotting analysis demonstrated that the expression levels of cyclin D1, cyclin E2, cyclin A and cyclin B1 were decreased.	Propidium	0-16	cyclin E2	Homo sapiens	164-173
29805688-3	2018	Propidium iodide staining analysis identified the cell cycle arrest of G1 phase and western blotting analysis demonstrated that the expression levels of cyclin D1, cyclin E2, cyclin A and cyclin B1 were decreased.	Propidium	0-16	cyclin A2	Homo sapiens	175-183
29805688-3	2018	Propidium iodide staining analysis identified the cell cycle arrest of G1 phase and western blotting analysis demonstrated that the expression levels of cyclin D1, cyclin E2, cyclin A and cyclin B1 were decreased.	Propidium	0-16	cyclin B1	Homo sapiens	188-197
29784046-3	2018	METHODS: The role of annexin A5 in resistance to EGFR tyrosine kinase inhibitors was investigated by qPCR and western blot of relevant molecules, by CCK8 and EdU assay of cell proliferation and viability, by annexin V/propidium iodide assay of apoptosis and cell cycle distribution, by JC-1 assay of mitochondrial integrity, and by xenograft assay of tumorigenicity.	Propidium	218-234	annexin A5	Homo sapiens	21-31
29480936-9	2018	Consistently, with these results, CA3 pyramidal cells exhibited reduced propidium iodide uptake and caspase-3 activity in slices pretreated with BDNF and exposed to OGD-RP.	Propidium	72-88	brain-derived neurotrophic factor	Rattus norvegicus	145-149
29532890-5	2018	Furthermore, lncTCF7 silencing in SW-620 and HT29 CRC cell lines inhibited the proliferation, cell cycle, migration and invasion of cells, as determined by Cell Counting Kit-8 assays, propidium iodide (PI) staining and flow cytometry, wound healing assays and Transwell invasion assays, respectively; however, Annexin V/PI double staining and flow cytometry indicated that lncTCF7 silencing did not significantly affect the apoptosis of CRC cells.	Propidium	184-200	WNT signaling pathway activating non-coding RNA	Homo sapiens	13-20
29488611-8	2018	miR-205-5p accelerated cell apoptosis through inhibiting PTK7, demonstrated using Annexin V-FITC/propidium iodide staining.	Propidium	97-113	microRNA 205	Homo sapiens	0-7
29488611-8	2018	miR-205-5p accelerated cell apoptosis through inhibiting PTK7, demonstrated using Annexin V-FITC/propidium iodide staining.	Propidium	97-113	protein tyrosine kinase 7 (inactive)	Homo sapiens	57-61
29438799-5	2018	Annexin V/Propidium Iodide apoptosis assay also demonstrated that lig4-4 obviously reduced cell apoptosis in OGD/R-injured neurons.	Propidium	10-26	DNA ligase 4	Rattus norvegicus	66-72
29193033-4	2018	KWSY:MTD causes membrane permeability which allows propidium iodide entry into the cytosol and the release of HMGB1 into the media, indicative of necrosis.	Propidium	51-67	BCL2-related ovarian killer	Mus musculus	5-8
29614833-5	2018	Our results demonstrate, by 3-(4,5-dimethyl thiazol-2-yl-)-2,5-diphenyl tetrazolium bromide (MTT) and Annexin V-fluoresce isothiocyanate (FITC)/propidium iodide (PI) double-staining assays, that rhein significantly inhibited cell viability and induced apoptosis in HepaRG cells.	Propidium	144-160	annexin A5	Homo sapiens	102-111
29467861-3	2018	Cell membrane integrity was assessed using fluorescence microscopy to assess the uptake of annexin V-FITC/propidium iodide (PI).	Propidium	106-122	annexin A5	Homo sapiens	91-100
29403356-2	2017	Glutamate triggered CAST/calpain2-mediated necrosis regulation in primary cultured retinal neurons, as demonstrated by propidium iodide-staining and lactate dehydrogenase assay.	Propidium	119-135	calpastatin	Rattus norvegicus	20-24
29403356-2	2017	Glutamate triggered CAST/calpain2-mediated necrosis regulation in primary cultured retinal neurons, as demonstrated by propidium iodide-staining and lactate dehydrogenase assay.	Propidium	119-135	calpain 2	Rattus norvegicus	25-33
29303982-5	2018	In this study, the cytotoxic effects of the curcumin analog DK1 was investigated in both U-2OS and MG-63 osteosarcoma cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and cell death was microscopically examined via acridine orange/propidium iodide (AO/PI) double staining.	Propidium	272-288	immunoglobulin heavy diversity 5-12	Homo sapiens	60-63
29436630-10	2018	The results of CCK-8 assay, cell cycle analysis, wound healing assay, Annexin V/propidium iodide staining assay and TUNEL assay all demonstrated that the silencing of B7-H4 by small interfering RNA decreased cell proliferation, suppressed cell motility, and induced cell cycle arrest and the apoptosis of MGC-803 human gastric cancer cells.	Propidium	80-96	V-set domain containing T cell activation inhibitor 1	Homo sapiens	167-172
28484798-6	2018	Immediately after a microsecond pulse, YO-PRO-1 and propidium enter the cell roughly equally from the positive and negative poles, but transport through the cathode-facing side dominates in less than 1 s. After nanosecond pulse permeabilization, YO-PRO-1 and propidium enter primarily on the anode-facing side of the cell.	Propidium	259-268	lamin A/C	Homo sapiens	42-47
29451308-8	2018	Cell viability by propidium iodide exclusion was reduced to 10% in BC2 on Day 1 versus 65 and 60% for baseline and BC1.	Propidium	18-34	charged multivesicular body protein 2A	Homo sapiens	67-70
29434041-4	2018	Analysis of DNA content by propidium iodide (PI) staining revealed cells with &gt;4N DNA content (polyploidy) markedly increased after CFI-400945 treatment.	Propidium	27-43	complement factor I	Homo sapiens	135-138
28982949-6	2017	The propidium iodide-positive cells stained positive for annexin V, negative for vimentin and pale for toluidine blue.	Propidium	4-20	annexin A5	Homo sapiens	57-66
29389557-7	2018	Apoptosis, as determined by Annexin V and propidium iodide analysis, indicated that CMP could mediate BNL 1MEA.7R.1 apoptosis, but not necrosis.	Propidium	42-58	matrilin 1, cartilage matrix protein	Mus musculus	84-87
28982949-6	2017	The propidium iodide-positive cells stained positive for annexin V, negative for vimentin and pale for toluidine blue.	Propidium	4-20	vimentin	Homo sapiens	81-89
29186056-7	2017	Here, we extend this study by solving the crystal structures of human BChE in complex with five reversible ligands, namely, decamethonium, thioflavin T, propidium, huprine, and ethopropazine.	Propidium	153-162	butyrylcholinesterase	Homo sapiens	70-74
29344203-5	2017	MUC1 overexpression resulted in &gt;60% reduction in apoptosis induced by irradiation, as determined by Annexin-V/propidium iodide double staining and flow cytometry analysis.	Propidium	114-130	mucin 1, cell surface associated	Homo sapiens	0-4
28951199-5	2017	The proportion of annexin V positive and propidium iodide negative cells was increased in CD4 and CD8 double negative, double positive and single positive T cells from T cell-specific PAR2-null mice.	Propidium	41-57	CD4 antigen	Mus musculus	90-93
28852892-5	2017	Additionally, recombinant neuritin reduced the number of apoptotic cells at the early stage according to Annexin V/propidium iodide staining and inhibited cell proliferation according to MTT assay results.	Propidium	115-131	neuritin 1	Rattus norvegicus	26-34
28951199-5	2017	The proportion of annexin V positive and propidium iodide negative cells was increased in CD4 and CD8 double negative, double positive and single positive T cells from T cell-specific PAR2-null mice.	Propidium	41-57	coagulation factor II (thrombin) receptor-like 1	Mus musculus	184-188
29212239-8	2017	Furthermore, endostatin overexpression enhanced apoptosis (as showed by AnnexinV-FITC/propidiumiodide staining analysis), induced differentiation and blocked the cell cycle.	Propidium	86-101	collagen type XVIII alpha 1 chain	Homo sapiens	13-23
28944894-7	2017	Fluorescence microscopy was used to observe the apoptosis of liver cells stained by Annexin V-fluorescein isothiocyanate/propidium iodide.	Propidium	121-137	annexin A5	Homo sapiens	84-93
29085465-9	2017	Flow cytometry analysis of cells stained with Annexin V/propidium iodide indicated that the overexpression of RBM10 induced apoptosis in A549 cells.	Propidium	56-72	RNA binding motif protein 10	Homo sapiens	110-115
28370536-5	2017	In flow cytometry-based apoptosis assay, FLI1 siRNA-transduced HDMECs revealed the decreased number of annexin and propidium iodide-double-positive apoptotic cells compared with control cells, reflecting the promotion of cell survival.	Propidium	115-131	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	41-45
28705727-6	2017	Reverse Transcription Polymerase chain reaction (RT-PCR), immunofluorescence, immunohistochemistry and Annexin V binding and propidium iodide analyses revealed that the Piezo1 protein ion channel was highly expressed in human NP cells, which are the primary cells that comprise the intervertebral disc.	Propidium	125-141	piezo type mechanosensitive ion channel component 1	Homo sapiens	169-175
28953230-5	2017	The activity of TR2-3 in inducing apoptosis in cancer cells was evaluated by using an Annexin V-PE apoptosis detection kit in combination with flow cytometry and the Hoechst 33342 and propidium iodide double staining analysis.	Propidium	184-200	nuclear receptor subfamily 2 group C member 1	Homo sapiens	16-21
27990564-4	2017	Inhibition by classic protonable amine and quaternary reversible inhibitors (ethopropazine, donepezil, tacrine, edrophonium, BW284c51, propidium) shows that DjChE is far less sensitive to these inhibitors than human AChE, suggesting discrete differences in active center and peripheral site recognition and structures.	Propidium	135-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	216-220
28549973-5	2017	An increase in the concentration of CRM197 and ApoE decreased the transendothelial electrical resistance and increased the ability of propidium iodide and RA to cross the BBB.	Propidium	134-150	apolipoprotein E	Homo sapiens	47-51
29256223-4	2017	The effect of CXCR4, PI3K/Akt pathway inhibitor LY294002 and ERK pathway inhibitor U0126 on cell cycle of breast cancer was detected by propidium iodide staining.	Propidium	136-152	EPH receptor B2	Homo sapiens	61-64
28342001-7	2017	Loss-of-function of GLI-1 or GLI-2 also increased the cell numbers of apoptotic cells positive for staining of Annexin-V and propidium iodide (PI) and the terminal deoxynucleotidyl transferase dUTP-biotin nick-end labeling (TUNEL) method, and induced DNA fragmentation.	Propidium	125-141	GLI family zinc finger 1	Homo sapiens	20-25
28342001-7	2017	Loss-of-function of GLI-1 or GLI-2 also increased the cell numbers of apoptotic cells positive for staining of Annexin-V and propidium iodide (PI) and the terminal deoxynucleotidyl transferase dUTP-biotin nick-end labeling (TUNEL) method, and induced DNA fragmentation.	Propidium	125-141	GLI family zinc finger 2	Homo sapiens	29-34
28781653-5	2017	Depletion of TRIM11 in A2780 and SK-OV-3 ovarian cancer cells by transfection of specific small interfering RNA significantly suppressed proliferation and inhibited invasion of cells, even induced apoptosis as indicated by both Cell Counting Kit-8, Annexin V/propidium iodide staining and Transwell assay.	Propidium	259-275	tripartite motif containing 11	Homo sapiens	13-19
28532669-5	2017	Additionally, 1 induced the upregulation of the caspase-9 and procaspase-9 levels in Western blots and increased the annexin V/propidium iodide (PI)-positive cell population in flow cytometry.	Propidium	127-143	annexin A5	Homo sapiens	117-126
28533778-6	2017	In contrast to IL-1beta release, Dnase1L3 inhibition only mildly impaired NLRP3-dependent pyroptosis, as measured by propidium iodide uptake or LDH release.	Propidium	117-133	deoxyribonuclease 1-like 3	Mus musculus	33-41
28744401-9	2017	PCAIs induced apoptotic cell death in PC 3 and DU 145 cells as determined by annexin V/propidium iodide flow cytometry analysis through the activation of caspases 3 and 8 while also inhibiting migration and invasion through the disruption of F-actin organization.	Propidium	87-103	chromobox 8	Homo sapiens	38-42
28721072-4	2017	METHODS: CXCL12 blocks cisplatin-induced apoptosis in A549, and the results were shown by propidium iodide/annexin V staining in vitro.	Propidium	90-106	C-X-C motif chemokine ligand 12	Homo sapiens	9-15
28440427-6	2017	The lactate dehydrogenase, MTT, Annexin V/propidium iodide apoptosis and caspase-3 activity assays showed that downregulation of miR-200c markedly improved cell survival and suppressed the apoptosis of cardiomyocytes in response to hypoxia.	Propidium	42-58	microRNA 200c	Homo sapiens	129-137
28351885-4	2017	Propidium iodide-based cell-cycle analysis of Skiv2l2 knockdown cells revealed defective progression through the G2/M phase and an accumulation of mitotic cells, suggesting SKIV2L2 contributes to mitotic progression.	Propidium	0-16	Mtr4 exosome RNA helicase	Mus musculus	46-53
28351885-4	2017	Propidium iodide-based cell-cycle analysis of Skiv2l2 knockdown cells revealed defective progression through the G2/M phase and an accumulation of mitotic cells, suggesting SKIV2L2 contributes to mitotic progression.	Propidium	0-16	Mtr4 exosome RNA helicase	Mus musculus	173-180
28475602-7	2017	Our results demonstrated that PRL afforded neuroprotection against Glu excitotoxicity, as evidenced by a decrease in propidium iodide staining and by the decrease of the LDH activity.	Propidium	117-133	prolactin	Rattus norvegicus	30-33
27997127-9	2017	Pt-Mal-LHRH was confirmed to be cytotoxic by flow cytometry using a propidium iodide stain.	Propidium	68-84	gonadotropin releasing hormone 1	Mus musculus	7-11
27841867-8	2017	CC-RCC treatment with ROCK inhibitors is cytotoxic and cytostatic based on bromodeoxyuridine (BrdU) assay, propidium iodide (PI) staining and growth curves, and blocks cell migration based on transwell assay.	Propidium	107-123	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	22-26
27907860-5	2017	This was further supported using a flow-cytometry (Annexin V/propidium iodide assay), which revealed a significant increase in apoptotic cells in both the cell lines after the co-administration of VP-16 and Bcl-2 Aso using oMWCNTs-PEG hybrid, and fluorescence microscopy, which showed an increase in reactive oxygen species identified after Bcl-2 knock-down.	Propidium	61-77	host cell factor C1	Homo sapiens	197-202
28131165-8	2017	Annexin V-FITC/propidium iodide (PI) double staining results confirmed that ginsenoside Rg1 significantly reduced the OGD-induced apoptosis in NSCs.	Propidium	15-31	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	88-91
27907860-5	2017	This was further supported using a flow-cytometry (Annexin V/propidium iodide assay), which revealed a significant increase in apoptotic cells in both the cell lines after the co-administration of VP-16 and Bcl-2 Aso using oMWCNTs-PEG hybrid, and fluorescence microscopy, which showed an increase in reactive oxygen species identified after Bcl-2 knock-down.	Propidium	61-77	BCL2 apoptosis regulator	Homo sapiens	207-212
27822872-9	2017	ICER seems to be responsible for decrease in G1 transition, based on reduced Cdk4 protein, decreased proliferation and functional studies with propidium iodide.	Propidium	143-159	cAMP responsive element modulator	Homo sapiens	0-4
27904661-4	2016	We demonstrated that SphK1 is highly expressed in SK-NEP-1 and G401 cells, and through annexin V/propidium iodide staining and flow cytometry analysis, we detected cell apoptosis.	Propidium	97-113	sphingosine kinase 1	Homo sapiens	21-26
27836573-8	2017	PKH+ MSCs rapidly became positive for annexin V, propidium iodide and calreticulin, indicating loss of cell integrity.	Propidium	49-65	pyridoxal kinase	Homo sapiens	0-3
28105237-3	2016	The effects of xanthohumol on the cell viability and apoptosis rate of laryngeal squamous cell carcinoma SCC4 cells were assessed by Annexin V-fluorescein isothiocyanate/propidium iodide staining.	Propidium	170-186	MAU2 sister chromatid cohesion factor	Homo sapiens	105-109
27818231-14	2016	The function of RASSF1A reactivation in promoting apoptosis and inducing G2/M cell cycle arrest was analyzed using flow-cytometry analysis with Annexin V and propidium iodide (PI).	Propidium	158-174	Ras association domain family member 1	Homo sapiens	16-23
28231726-8	2017	Annexin V/propidium iodide staining and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling assay confirmed that cell apoptosis increased after TRPM2-AS knockdown.	Propidium	10-26	TRPM2 antisense RNA	Homo sapiens	162-170
28803243-12	2017	Annexin-V-binding and propidium iodide staining were significantly higher in ChAc fibroblasts than in control fibroblasts.	Propidium	22-38	vacuolar protein sorting 13 homolog A	Homo sapiens	77-81
28803243-13	2017	In ChAc fibroblasts annexin-V-binding and propidium iodide staining were significantly decreased by lithium treatment, significantly increased by 2-APB and virtually lithium insensitive in the presence of 2-APB.	Propidium	42-58	vacuolar protein sorting 13 homolog A	Homo sapiens	3-7
27951646-9	2016	The Ngb fibril probably promoted toxicity by inducing channel formation in the cell membrane, as investigated here using synthetic lipid bilayer membranes and the propidium iodide uptake assay.	Propidium	163-179	neuroglobin	Homo sapiens	4-7
27849354-4	2016	ENL and G1 (the specific agonist of GPER) inhibited the proliferation of human prostate stromal cell line WPMY-1 as shown by MTT assay and arrested cell cycle at the G0/G1 phase, which was displayed by propidium iodide staining following flow cytometer examination.	Propidium	202-218	G protein-coupled estrogen receptor 1	Homo sapiens	36-40
27900034-6	2016	The present study also revealed that the overexpression of miR-520e could suppress breast cancer cell apoptosis, revealed using Annexin V/propidium iodide double staining and flow cytometry analysis.	Propidium	138-154	microRNA 520e	Homo sapiens	59-67
27895479-8	2016	The apoptosis induction was also confirmed by the rise in sub-G1 phase of cell cycle assay and apoptosis percentage of annexin V/propidium iodide assay.	Propidium	129-145	annexin A5	Homo sapiens	119-128
27793926-6	2016	RESULTS: A 10-min treatment with hBD3 (70 mug/ml) induced propidium iodide uptake in lung cancer cells.	Propidium	58-74	defensin beta 103B	Homo sapiens	33-37
27325640-7	2016	Accordingly, Abeta increased the annexin V/propidium iodide (PI)-positive cell fraction and the degradation of poly (ADP ribose) polymerase and caspase-3 in HT22 cells.	Propidium	43-59	amyloid beta (A4) precursor protein	Mus musculus	13-18
26990000-4	2016	Further studies revealed that selected hybrid 5 could induce apoptosis in Hep-G2 cells through the investigation of acridine orange/ethidium bromide, Hoechst 33258 fluorescence stainings, and annexin V/propidium iodide assay.	Propidium	202-218	DNL-type zinc finger	Homo sapiens	74-77
28203523-10	2016	Cell death induced by GPx4 knockdown was characterized by positive staining for both annexin V and propidium iodide, nuclear translocation of AIF, and without activation of caspase 3, and was rescued by alpha-tocopherol and ferrostatin-1.	Propidium	99-115	glutathione peroxidase 4	Homo sapiens	22-26
27188390-7	2016	RESULTS: Propidium iodide staining showed that P10 in combination with SAHA induced cell death in Nalm6 cells, in which PARP expression and activity is high with a combination index of &lt;0.2.	Propidium	9-25	S100 calcium binding protein A10	Homo sapiens	47-50
27722009-7	2016	Finally, loss of SIRT3 in cisplatin-exposed cells removed the protective effect of PARP1 inhibition against oxidative stress, represented by the concentration of lipid hydroperoxide and 8-hydroxy-2"-deoxyguanosine; and necrotic cell death represented by a percentage of propidium iodide-positively stained cells.	Propidium	270-286	sirtuin 3	Homo sapiens	17-22
27722009-7	2016	Finally, loss of SIRT3 in cisplatin-exposed cells removed the protective effect of PARP1 inhibition against oxidative stress, represented by the concentration of lipid hydroperoxide and 8-hydroxy-2"-deoxyguanosine; and necrotic cell death represented by a percentage of propidium iodide-positively stained cells.	Propidium	270-286	poly(ADP-ribose) polymerase 1	Homo sapiens	83-88
28485347-5	2016	Furthermore, VEGF transcript was silenced by siRNA and the effects on cell migration, viability, and proliferation were determined by the wound healing assay, MTT assay, and propidium iodide staining, respectively.	Propidium	174-190	vascular endothelial growth factor A	Homo sapiens	13-17
26944067-4	2016	In vitro, TRAIL(+) exosomes induced more pronounced apoptosis (detected by Annexin V/propidium iodide and activated caspase-3) in TRAIL-death receptor (DR)5(+) cells (SUDHL4 lymphoma and INT12 melanoma), with respect to the DR5(-)DR4(+)KMS11 multiple myeloma.	Propidium	85-101	TNF superfamily member 10	Homo sapiens	10-15
26096706-10	2016	Propidium iodide (PI) staining combined with flow cytometry analysis also showed that Bcl11b KD led to the cell cycle arrest of U87 and U251 cells at the G0/G1 or at the S phase, indicating that Bcl11b is required for glioma cell cycle progression.	Propidium	0-16	BAF chromatin remodeling complex subunit BCL11B	Homo sapiens	86-92
27373212-5	2016	Knockdown of MCT1 or/and PFKFB3 increased the apoptosis rate of the HUVECs under single-culture and co-culture situations by staining with calcein and propidium iodide.	Propidium	151-167	solute carrier family 16 member 1	Homo sapiens	13-17
27373212-5	2016	Knockdown of MCT1 or/and PFKFB3 increased the apoptosis rate of the HUVECs under single-culture and co-culture situations by staining with calcein and propidium iodide.	Propidium	151-167	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	25-31
26815504-5	2016	Finally, the cell survival mediated by the Gli1-dependent BIRC3 transcription was studied by MTT and annexin V-FITC/propidiumiodide (PI) assays.	Propidium	116-131	GLI family zinc finger 1	Homo sapiens	43-47
27980586-8	2016	Furthermore, flow cytometry (FACS) was used to quantitatively detect the apoptotic rate by double labeling techniques using Annexin-V FITC/propidium iodide staining analysis and apoptotic proteins expression done by western blotting assay method.	Propidium	139-155	acyl-CoA synthetase long-chain family member 1	Mus musculus	29-33
26815504-5	2016	Finally, the cell survival mediated by the Gli1-dependent BIRC3 transcription was studied by MTT and annexin V-FITC/propidiumiodide (PI) assays.	Propidium	116-131	baculoviral IAP repeat containing 3	Homo sapiens	58-63
27035327-7	2016	Furthermore, flow cytometric analysis demonstrated that the majority of U937 cells were arrested in G0/G1 phase and sub-G1 phase after RPS15A knockdown, as determined using propidium iodide staining.	Propidium	173-189	ribosomal protein S15a	Homo sapiens	135-141
27173251-4	2016	Flow cytometry was used to detect apoptosis induced by Annexin V-fluorescein isothiocyanate/propidium iodide-double labeling.	Propidium	92-108	annexin A5	Homo sapiens	55-64
27064569-6	2016	Annexin V--fluorescein isothiocyanate / propidium iodide staining flow cytometry, DNA ladder and cell cycle distribution assays.	Propidium	40-56	annexin A5	Homo sapiens	0-9
26935516-8	2016	In addition, PHLDA2 significantly induced apoptosis, as evidenced by Annexin V-FITC/propidium iodide (PI) and Hoechst staining, along with activation of Bax and caspase-3 and also decreased Bcl-2 expression.	Propidium	84-100	pleckstrin homology like domain family A member 2	Homo sapiens	13-19
26998037-5	2016	Cell apoptosis rate was analyzed using flow cytometry and Annexin V-fluorescein isothiocyanate/propidium iodide staining demonstrated that beta-catenin siRNA significantly increased the apoptosis of U251 cells (P&lt;0.01).	Propidium	95-111	catenin beta 1	Homo sapiens	139-151
26935015-9	2016	In addition, flow cytometric analysis indicated that LPS stimulation did not induce apoptosis but substantially augmented necrosis, as evidenced by staining with annexin V/propidium iodide.	Propidium	172-188	toll-like receptor 4	Mus musculus	53-56
27800139-14	2016	Cell cycle analysis following ectopic expression of miR-375 in the NT-2 cells using propidium iodine staining revealed significant extension in sub-G1 cell cycle.	Propidium	84-100	microRNA 375	Homo sapiens	52-59
26925328-11	2016	CTH-treated HepG2 cells presented also pro-apoptotic features, such as increased Annexin V/propidium iodide (PI) binding and dose-dependent morphological alterations in DAPI-stained cells.	Propidium	91-107	V-set and immunoglobulin domain containing 2	Homo sapiens	0-3
26998277-4	2016	The MTT assay demonstrated that sequential treatment of cisplatin, followed by the Akt inhibitor, MK-2206, caused a synergistic effect of proliferation inhibition, and the apoptosis assay by propidium iodide/fluorescein isothiocyanate staining also showed that combination treatment induced more apoptosis compared to the monotherapy groups.	Propidium	191-207	AKT serine/threonine kinase 1	Homo sapiens	83-86
26820261-4	2016	The rates of cell proliferation and apoptosis, the cell cycle profiles and the mRNA expression of B-cell lymphoma 2 (Bcl-2) were detected using cell counting kit-8, multicaspase assays, propidium iodide staining and reverse transcription-quantitative polymerase chain reaction, respectively.	Propidium	186-202	BCL2 apoptosis regulator	Homo sapiens	117-122
26663397-8	2016	Following overexpression of RGS5, fluorescence-activated cell sorting analysis of propidium iodide-stained cells indicated cell cycle arrest in G0/G1 phase.	Propidium	82-98	regulator of G-protein signaling 5	Mus musculus	28-32
26610752-7	2016	KD of TRAF2 or STAT3 reduced cytokine-induced caspase 3/7 activation, but, intriguingly, potentiated cytokine-mediated loss of plasma membrane integrity and augmented the number of propidium iodide-positive cells.	Propidium	181-197	Tnf receptor-associated factor 2	Rattus norvegicus	6-11
26573263-7	2016	Additionally, suppression of the expression of SOX18 in the osteosarcoma cells significantly induced cell apoptosis as evaluated by annexin V/propidium iodide staining and flow cytometric analysis.	Propidium	142-158	SRY-box transcription factor 18	Homo sapiens	47-52
27102915-4	2016	Using organotypic hippocampal slice cultures exposed to glutamate, we demonstrated that preincubation of the slices with the BKCa channel opener NS1619 resulted in decreased neuronal cell death measured as reduced uptake of propidium iodide.	Propidium	224-240	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	125-129
27832629-7	2016	The changes included G1 and G2/M phase arrest of the cell cycle, and a downregulation of the expression at both the protein and mRNA levels of cyclin D1 and CDK4 (related to the G1 phase) and of cyclin B1 and CDK1 (related to the G2/M phase) as measured by flow cytometry after propidium iodide staining, and both western blot and real-time PCR, respectively.	Propidium	278-294	cyclin D1	Homo sapiens	143-152
27832629-7	2016	The changes included G1 and G2/M phase arrest of the cell cycle, and a downregulation of the expression at both the protein and mRNA levels of cyclin D1 and CDK4 (related to the G1 phase) and of cyclin B1 and CDK1 (related to the G2/M phase) as measured by flow cytometry after propidium iodide staining, and both western blot and real-time PCR, respectively.	Propidium	278-294	cyclin dependent kinase 4	Homo sapiens	157-161
26058460-6	2016	SelS gene silence by small interference RNA (siRNA) rendered VSMCs more sensitive to hydrogen peroxide- or tunicamycin- induced injury and apoptosis, as determined by MTT assay, Hoechst staining, and annexin V/propidium iodide staining.	Propidium	210-226	selenoprotein S	Homo sapiens	0-4
27843533-5	2016	The cytometer-based Annexin V/propidium iodide (PI) staining showed that CPT and NPOA cotreatment causes an increased population of apoptotic cells compared to CPT treatment alone.	Propidium	30-46	choline phosphotransferase 1	Homo sapiens	73-76
26415803-10	2015	In the ex vivo study, the caspase-1/propidium iodide-positive cells, caspase-1 specks and ASC pyroptosomes were up-regulated in AMs following LPS/ATP stimulation.	Propidium	36-52	caspase 1	Mus musculus	26-35
26375442-9	2015	Combination of miR-130a and miR-495 significantly decreased apoptosis determined by Annexin V-FITC/propidium iodide staining and flow cytometric analysis, and the expression of Bim in SNU484 gastric cancer cells.	Propidium	99-115	microRNA 130a	Homo sapiens	15-23
26375442-9	2015	Combination of miR-130a and miR-495 significantly decreased apoptosis determined by Annexin V-FITC/propidium iodide staining and flow cytometric analysis, and the expression of Bim in SNU484 gastric cancer cells.	Propidium	99-115	microRNA 495	Homo sapiens	28-35
26212551-4	2015	Antimycin-A (0.1muM) and lipopolysaccharide (1ng/ml) caused low neurotoxicity on their own, measured as propidium iodide fluorescence in CA1 and CA3 regions.	Propidium	104-120	carbonic anhydrase 1	Rattus norvegicus	137-140
26450067-9	2015	RIP3 staining using propidium iodide (PI)-labeled sections showed most of the PI-labeled cells were observed as RIP3-positive.	Propidium	20-36	receptor-interacting serine-threonine kinase 3	Mus musculus	0-4
26450067-9	2015	RIP3 staining using propidium iodide (PI)-labeled sections showed most of the PI-labeled cells were observed as RIP3-positive.	Propidium	20-36	receptor-interacting serine-threonine kinase 3	Mus musculus	112-116
26823806-4	2015	The expression levels of Bax and Bcl-2 proteins were detected by Annexin V/propidium iodide coupled staining.	Propidium	75-91	BCL2 associated X, apoptosis regulator	Homo sapiens	25-28
26823806-4	2015	The expression levels of Bax and Bcl-2 proteins were detected by Annexin V/propidium iodide coupled staining.	Propidium	75-91	BCL2 apoptosis regulator	Homo sapiens	33-38
26397753-6	2015	Transfection with the miR-146b inhibitor enhanced the release of lactate dehydrogenase and increased hypoxia-induced apoptosis, as determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling, Hoechst 33258 staining, JC-1 assay (measuring mitochondrial membrane permeability) and annexin V/propidium iodide analysis.	Propidium	304-320	microRNA 146b	Rattus norvegicus	22-30
26722269-6	2015	CTDP1 was subsequently silenced in GC cells by lentivirus-mediated small interfering RNA (siRNA) infection, and the effects of CTDP1 inhibition on cell proliferation were evaluated by cell number counting, cell cycle analysis with propidium iodide staining and fluorescence-activated cell sorting (FACS) analysis, apoptotic rate with Annexin V staining and FACS analysis, as well as colony formation assay in GC cells.	Propidium	231-247	CTD phosphatase subunit 1	Homo sapiens	0-5
25880119-6	2015	TRIM21 expression was assessed in relation to lymphocyte proliferation by quantitative PCR and correlated with (3) H-thymidine incorporation and propidium iodine staining.	Propidium	145-161	tripartite motif containing 21	Homo sapiens	0-6
26251950-4	2015	Our results indicated that HBx inhibited apoptosis and induced invasion as detected using Annexin V/propidium iodide (PI) double staining and Transwell assay, respectively.	Propidium	100-116	X protein	Hepatitis B virus	27-30
26238997-4	2015	Furthermore, RIP3 expression was co-localized with propidium iodide (PI)-positive staining (necrotic cells).	Propidium	51-67	receptor-interacting serine-threonine kinase 3	Mus musculus	13-17
25738414-5	2015	Furthermore, Annexin V/propidium iodide staining and flow cytometric analysis demonstrated that TNF-alpha increased PC12-cell apoptosis from 3.49 to 40.74% in the negative control and PC group, and the apoptotic rate was significantly reduced upon co-culture with BMSCs to 16.97%.	Propidium	23-39	tumor necrosis factor	Rattus norvegicus	96-105
25735224-5	2015	MTT assays showed that overexpression of TMSG1/LASS2 inhibited cell proliferation; and morphological observations and flow cytometric assays with Annexin V/propidium iodide showed TMSG1/LASS2 overexpression increased apoptosis in these cells.	Propidium	156-172	ceramide synthase 2	Homo sapiens	41-46
25735224-5	2015	MTT assays showed that overexpression of TMSG1/LASS2 inhibited cell proliferation; and morphological observations and flow cytometric assays with Annexin V/propidium iodide showed TMSG1/LASS2 overexpression increased apoptosis in these cells.	Propidium	156-172	ceramide synthase 2	Homo sapiens	180-185
25735224-5	2015	MTT assays showed that overexpression of TMSG1/LASS2 inhibited cell proliferation; and morphological observations and flow cytometric assays with Annexin V/propidium iodide showed TMSG1/LASS2 overexpression increased apoptosis in these cells.	Propidium	156-172	ceramide synthase 2	Homo sapiens	186-191
26121639-4	2015	We demonstrate strong specific IgM binding to a subset of Annexin-V (AnnV)+PI (Propidium Iodide)+ apoptotic cells with disrupted cell membranes.	Propidium	79-95	immunoglobulin heavy constant mu	Mus musculus	31-34
26121639-4	2015	We demonstrate strong specific IgM binding to a subset of Annexin-V (AnnV)+PI (Propidium Iodide)+ apoptotic cells with disrupted cell membranes.	Propidium	79-95	annexin A5	Homo sapiens	58-67
25867234-0	2015	The value of cell cycle analysis by propidium-iodine staining of CD56+ cells in pediatric brain tumors.	Propidium	36-45	neural cell adhesion molecule 1	Homo sapiens	65-69
26000607-5	2015	Unexpectedly, inhibition of ROS by either N-acetyl-L-cysteine (NAC), a peroxide inhibitor, or Tempol, a superoxide inhibitor, increased the annexin V-/propidium iodide (PI)+ early necrotic population in TRAIL-treated cells.	Propidium	151-167	X-linked Kx blood group	Homo sapiens	63-66
26000607-5	2015	Unexpectedly, inhibition of ROS by either N-acetyl-L-cysteine (NAC), a peroxide inhibitor, or Tempol, a superoxide inhibitor, increased the annexin V-/propidium iodide (PI)+ early necrotic population in TRAIL-treated cells.	Propidium	151-167	annexin A5	Homo sapiens	140-149
25701464-6	2015	The effect of depletion of CUGBP1 was evaluated by MTT assay and Annexin/Propidium Iodide Apoptosis assay.	Propidium	73-89	CUGBP Elav-like family member 1	Homo sapiens	27-33
25047904-7	2015	The molecular cytotoxicity of the CAV toxin was tested through evaluation of the apoptosis/necrosis ratio by double staining with annexin V-FITC and a propidium iodide (PI) assay.	Propidium	151-167	caveolin 2	Homo sapiens	34-37
25698398-2	2015	Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular reactive oxygen species (ROS) production and propidium iodide uptake.	Propidium	112-128	receptor interacting serine/threonine kinase 1	Homo sapiens	32-36
25698398-2	2015	Both complexes evoke necrosome (RIP1-RIP3)-dependent intracellular reactive oxygen species (ROS) production and propidium iodide uptake.	Propidium	112-128	receptor interacting serine/threonine kinase 3	Homo sapiens	37-41
25216324-4	2015	In the absence of growth factors, FoxK2 knockdown results in a dramatic increase in caspase 3 activity and propidium iodide positive cells, indicative of cell death.	Propidium	107-123	forkhead box K2	Mus musculus	34-39
25455534-9	2015	Mitochondrial membrane potential and apoptotic changes of the HTR-8/SVneo cell line in response to down-regulation of GRIM-19 were evaluated by 5,5",6,6"-Tetrachloro-1,1",3,3"-tetraethyl-imidacarbocyanine iodide and annexin V/propidium iodide.	Propidium	226-242	NADH:ubiquinone oxidoreductase subunit A13	Homo sapiens	118-125
24823432-4	2015	Moreover, increased apoptosis was also recorded by Annexin V-fluorescein isothiocyanate/propidium iodide staining.	Propidium	88-104	annexin A5	Homo sapiens	51-60
26176204-7	2015	TUNEL labeling and propidium iodide FACS analysis indicate that Rb-positive cells exposed to anti-ILK therapies are more susceptible to apoptosis and senescence than their Rb-deficient counterparts wherein aberrant mitosis induced by anti-ILK therapies exhibit mitotic arrest instead.	Propidium	19-35	integrin linked kinase	Homo sapiens	98-101
25338527-6	2015	The results from an MTT assay and from Annexin V-fluorescein isothiocyanate/propidium iodide staining indicated that interference of Notch 2 significantly inhibited the proliferation and induced the apoptosis of U251 cells.	Propidium	76-92	notch receptor 2	Homo sapiens	133-140
25084755-9	2015	Annexin V + propidium iodide staining showed time-dependent increase in percent apoptotic cells.	Propidium	12-28	annexin A5	Homo sapiens	0-9
25469108-7	2014	ADMSCs-TRAIL was subsequently assessed for anti-tumourigenic properties using both proliferation assay (MTS assay) and apoptosis assay (Annexin-V / Propidium Iodide staining).	Propidium	148-164	TNF superfamily member 10	Homo sapiens	7-12
25997957-5	2015	Dual staining with fluorescent Annexin V and propidium iodide (PI) was used to discriminate apoptotic or necrotic cell death.RIP3 expression was significantly lower in colorectal cancer and associated with T stage, M stage and AJCC stage.	Propidium	45-61	receptor interacting serine/threonine kinase 3	Homo sapiens	125-129
24998445-5	2014	Cell viability, cell cycle analysis and apoptosis were assessed by MTS assay, propidium iodide-Annexin V staining, and caspase 3/7 activity, respectively.	Propidium	78-94	annexin A5	Homo sapiens	95-104
25424877-9	2014	A flow cytometry using annexin V -FITC and propidium iodide (PI) staining revealed a significant increase in apoptotic RECQL1(-) cells.	Propidium	43-59	RecQ like helicase	Homo sapiens	119-125
25202073-3	2014	MATERIALS AND METHODS: Proliferation of different BCR-ABL(+) leukemic cells was measured with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; cell apoptosis with Annexin V/propidium iodide (PI) and flow cytometry.	Propidium	198-214	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	50-57
25412314-8	2014	Instead, SIM+MET treatment led to Ripk1- and Ripk3-dependent necrosis by 48-96 h, determined by propidium iodide-Annexin V flow cytometry, increase in Ripk1 and Ripk3 protein expression, necrosome formation, HMGB-1 extracellular release, and necrotic induction and viability rescue with necrostatin-1 and Ripk3-targeting siRNA.	Propidium	96-112	annexin A5	Homo sapiens	113-122
25377251-6	2014	Additionally, Rcan1-1L overexpression inhibited cell apoptosis under hypoxic conditions, as detected by annexin V-fluorescein isothiocyanate (FITC)/propidium iodide (PI) apoptosis assay.	Propidium	148-164	regulator of calcineurin 1	Homo sapiens	14-19
24957042-8	2014	Hoechst 33258/propidium iodide dual staining and flow cytometric analysis showed that SBP induced MDA-MB-231 cell apoptosis.	Propidium	14-30	selenium binding protein 1	Homo sapiens	86-89
25001514-6	2014	MANF decreased the number of the propidium iodide (PI)- and TUNEL-positive neural cells.	Propidium	33-49	mesencephalic astrocyte-derived neurotrophic factor	Rattus norvegicus	0-4
25179308-11	2014	Confocal microscopy confirmed the induction of apoptosis in HeLa cells when they were stained with 4",6-diamidino-2-phenylindole and propidium iodide after incubation with the Cytochrome c-based nanoparticles.	Propidium	133-149	cytochrome c, somatic	Homo sapiens	176-188
25119466-4	2014	Our results showed that when pre-treated with PPARgamma antagonists or PPARgamma siRNA, both breast cancer cell lines suppressed PTER-ITC-induced apoptosis, as determined by annexin V/propidium iodide staining and cleaved caspase-9 expression.	Propidium	184-200	peroxisome proliferator activated receptor gamma	Homo sapiens	46-55
25005497-7	2014	AKAP150 inhibition also abrogated high-glucose-induced cardiomyocyte apoptosis (TUNEL staining and annexin V/propidium iodide flow cytometry) and oxidative stress (ROS production, NADPH oxidase activity, and lipid peroxidation).	Propidium	109-125	A-kinase anchoring protein 5	Rattus norvegicus	0-7
25119466-4	2014	Our results showed that when pre-treated with PPARgamma antagonists or PPARgamma siRNA, both breast cancer cell lines suppressed PTER-ITC-induced apoptosis, as determined by annexin V/propidium iodide staining and cleaved caspase-9 expression.	Propidium	184-200	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
24738476-4	2014	Moreover, they displace propidium from the peripheral anionic site of AChE, preventing the beta-amyloid aggregation promoted by AChE.	Propidium	24-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	70-74
24824807-10	2014	Importantly, BNIP3 RNAi decreased lactate dehydrogenase release and the percentage of propidium iodide-positive cells, two markers of necrotic cell death due to rupture of the cell membrane, whereas it had no effect on activation of caspase-3 in Cd-treated cells.	Propidium	86-102	BCL2 interacting protein 3	Homo sapiens	13-18
24880989-12	2014	HeLa cells transfected with PSMT/p53 plasmid nanoparticles showed cellular damage and apoptosis, which was confirmed through propidium iodide staining.	Propidium	125-141	tumor protein p53	Homo sapiens	33-36
25080901-3	2014	The effect of SGI-1776 on the distribution of cell cycle phase was observed by flow cytometry with propidium iodide (PI) staining.	Propidium	99-115	semenogelin 1	Homo sapiens	14-17
24738476-4	2014	Moreover, they displace propidium from the peripheral anionic site of AChE, preventing the beta-amyloid aggregation promoted by AChE.	Propidium	24-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-132
24411335-7	2014	Propidium iodide (PI) flow cytometric assays were conducted to demonstrate that EGFP-p53/PEI/PAH-Cit/AuNP-CS elevated the level of apoptosis in PC-3 cells.	Propidium	0-16	tumor protein p53	Homo sapiens	85-88
24333586-4	2014	Six hours after an intravenous injection of propidium iodide labeled-NTS-polyplex, fluorescent spots were located in the cells of the organs with a mononuclear phagocyte system, suggesting NTS-polyplex clearance.	Propidium	44-60	neurotensin	Mus musculus	69-72
24333586-4	2014	Six hours after an intravenous injection of propidium iodide labeled-NTS-polyplex, fluorescent spots were located in the cells of the organs with a mononuclear phagocyte system, suggesting NTS-polyplex clearance.	Propidium	44-60	neurotensin	Mus musculus	189-192
24658657-6	2014	RESULTS: HO-1 induction lowered release of lactate dehydrogenase (LDH) and creatine phospho kinase (CK), decreased propidium iodide staining, improved cell morphology and preserved mitochondrial membrane potential in cardiomyocytes.	Propidium	115-131	heme oxygenase 1	Mus musculus	9-13
23813842-5	2014	To study the presence and significance of NLRP3-initiated pyroptotic cell death, we separated hepatocytes from nonparenchymal cells and developed a novel flow-cytometry-based (fluorescence-activated cell sorting; FACS) strategy to detect and quantify pyroptosis in vivo based on detection of active caspase 1 (Casp1)- and propidium iodide (PI)-positive cells.	Propidium	322-338	NLR family, pyrin domain containing 3	Mus musculus	42-47
23813842-5	2014	To study the presence and significance of NLRP3-initiated pyroptotic cell death, we separated hepatocytes from nonparenchymal cells and developed a novel flow-cytometry-based (fluorescence-activated cell sorting; FACS) strategy to detect and quantify pyroptosis in vivo based on detection of active caspase 1 (Casp1)- and propidium iodide (PI)-positive cells.	Propidium	322-338	acyl-CoA synthetase long-chain family member 1	Mus musculus	213-217
25451844-6	2014	Astrocytic, but not neuronal, spontaneous uptake of propidium iodide, an indicator of P2X7R channel/pore activity, was inhibited by representative antagonists of P2X7R, but they had no effect on the uptake by astrocytes in membrane-permeabilized fixed slices.	Propidium	52-68	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	86-91
24068565-5	2014	The effects of miR-34a ectopic expression on apoptosis of cisplatin-induce gastric cancer cell were determined by Annexin V/propidium iodide (PI) double staining method and flow cytometry.	Propidium	124-140	microRNA 34a	Homo sapiens	15-22
24100277-8	2014	Propidium iodide (PI) staining also showed that NAC restored membrane integrity, damaged by sodium meta-arsenite.	Propidium	0-16	X-linked Kx blood group	Homo sapiens	48-51
24389509-4	2014	Also, the mechanism of AChE inhibition of the most potent compounds has been thoroughly studied by kinetic studies, a propidium displacement assay, and molecular modelling.	Propidium	118-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	23-27
25451844-6	2014	Astrocytic, but not neuronal, spontaneous uptake of propidium iodide, an indicator of P2X7R channel/pore activity, was inhibited by representative antagonists of P2X7R, but they had no effect on the uptake by astrocytes in membrane-permeabilized fixed slices.	Propidium	52-68	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	162-167
24036210-3	2013	We found that down-regulating Homer1 expression with specific small interfering RNA (siRNA) significantly suppressed LDH release, reduced Propidium iodide (PI) or Hoechst staining, increased the number of tyrosine hydroxylase (TH) positive cells and DA uptake, and attenuated apoptotic and necrotic cell death after MPP(+) injury.	Propidium	138-154	homer scaffold protein 1	Homo sapiens	30-36
24072585-6	2014	Further characterization of this activity using propidium iodine staining revealed that PAL induced cell cycle arrest at G2/M phase in a manner dependent on its ability to bind GlcNAc.	Propidium	48-64	SHC binding and spindle associated 1	Homo sapiens	88-91
24216153-1	2014	The binding affinity of cationic DNA-staining dye, propidium iodide, with transport protein, bovine serum albumin, has been explored using UV-vis absorption, fluorescence, and circular dichroism spectroscopy.	Propidium	51-67	albumin	Homo sapiens	100-113
24216153-2	2014	Steady state and time resolved fluorescence studies authenticate that fluorescence quenching of bovine serum albumin by propidium iodide is due to bovine serum albumin-propidium iodide complex formation.	Propidium	120-136	albumin	Homo sapiens	103-116
24216153-2	2014	Steady state and time resolved fluorescence studies authenticate that fluorescence quenching of bovine serum albumin by propidium iodide is due to bovine serum albumin-propidium iodide complex formation.	Propidium	120-136	albumin	Homo sapiens	154-167
24216153-2	2014	Steady state and time resolved fluorescence studies authenticate that fluorescence quenching of bovine serum albumin by propidium iodide is due to bovine serum albumin-propidium iodide complex formation.	Propidium	168-184	albumin	Homo sapiens	103-116
24216153-2	2014	Steady state and time resolved fluorescence studies authenticate that fluorescence quenching of bovine serum albumin by propidium iodide is due to bovine serum albumin-propidium iodide complex formation.	Propidium	168-184	albumin	Homo sapiens	154-167
24216153-5	2014	Energy transfer efficiency and distance between bovine serum albumin and propidium iodide have been determined using Forster mechanism.	Propidium	73-89	albumin	Homo sapiens	55-68
23889203-7	2013	Cytotoxicity (uptake of propidium iodide) was assessed in the pyramidal cell layer of the CA1 region.	Propidium	24-40	carbonic anhydrase 1	Rattus norvegicus	90-93
24253565-5	2014	In G361 cells, Pa-PDT strongly induced PARP cleavage and subsequent apoptosis, which was confirmed using Annexin V/Propidium iodide double staining.	Propidium	115-131	collagen type XI alpha 2 chain	Homo sapiens	39-43
24142350-6	2013	Similarly to ZNS effects, the treatment with N-acetyl-cysteine (100 muM) displayed significant protective effects against rotenone-induced ROS production and Deltapsim at 4 and 12 h respectively, reaching the maximal extent at 24 h. Additionally, ZNS displayed antiapoptotic effects, as demonstrated by flow cytometric analysis of annexin V/propidium iodide double staining, and significant attenuated rotenone-increased caspase 3 activity.	Propidium	341-357	latexin	Homo sapiens	68-71
23907512-8	2013	Thiazolyl blue tetrazolium bromide assay, Hoechst33342/Propidium Iodide staining and Western blot assay showed that Tat-CRMP2 pretreatment increased cell viability compared with the control group against NMDA exposure by decreasing the cleavage of CRMP2.	Propidium	55-71	tyrosine aminotransferase	Homo sapiens	116-119
24215510-7	2013	Greater number of Annexin V-FITC and propidium iodide (PI)-positive tumor cells signified that COR-D induced apoptosis in vivo also.	Propidium	37-53	distribution of corticosterone in adrenal cortex cells	Mus musculus	95-98
24042845-8	2013	Annexin V-fluorescein isothiocyanate/propidium iodide staining and the Hoechst 33258 assay indicated that ZD55-IL-24 induced an increase in the number of apoptotic cells when administered in combination with PTX.	Propidium	37-53	interleukin 24	Homo sapiens	111-116
24179549-6	2013	Oridonin at concentrations of 12.5, 25, 50 and 100 muM resulted in increased apoptotic Annexin V-positive and propidium iodide-negative cells by 9.5, 15.6, 22.2 and 31.7%, respectively, compared with the control groups (P&lt;0.05).	Propidium	110-126	latexin	Homo sapiens	51-54
24141727-5	2013	The apoptotic effect on MEC-1 cells was evaluated by annexin V-fluorescein isothiocyanate/propidium iodide dual staining, followed by flow cytometry.	Propidium	90-106	ATR serine/threonine kinase	Homo sapiens	24-29
24145669-5	2013	annexin V/propidium iodide (PI) double staining detected by fluorescence microscopy and flow cytometry revealed a strong apoptosis-inducing ability for LPS in STC-1 cells.	Propidium	10-26	toll-like receptor 4	Mus musculus	152-155
24145669-5	2013	annexin V/propidium iodide (PI) double staining detected by fluorescence microscopy and flow cytometry revealed a strong apoptosis-inducing ability for LPS in STC-1 cells.	Propidium	10-26	stanniocalcin 1	Mus musculus	159-164
23907512-8	2013	Thiazolyl blue tetrazolium bromide assay, Hoechst33342/Propidium Iodide staining and Western blot assay showed that Tat-CRMP2 pretreatment increased cell viability compared with the control group against NMDA exposure by decreasing the cleavage of CRMP2.	Propidium	55-71	dihydropyrimidinase like 2	Homo sapiens	120-125
23693078-4	2013	Furthermore, the bromodeoxyuridine (BrdU) incorporation analyses and propidium iodide staining indicated that IRTKS can promote the entry into S phase of cell cycle progression.	Propidium	69-85	BAR/IMD domain containing adaptor protein 2 like 1	Homo sapiens	110-115
24119699-5	2013	A flow-cytometric assay based on Annexin V/ propidium iodide (Annexin V/PI) was used to measure the PS exposure of erythrocytes.	Propidium	44-60	annexin A5	Homo sapiens	62-74
23988451-6	2013	RESULTS: SGI-1776 treatment resulted in limited apoptosis in cell lines (mean 30%) and CD138(+) cells (&lt; 10%) assessed using Annexin-V/propidium iodide.	Propidium	138-154	chromogranin B	Homo sapiens	9-12
23624712-4	2013	In BBD9-treated U266 and RPMI 8226 cells, Annexin V (AV)-propidium iodide (PI) staining and FACS analysis demonstrated that apoptosis was involved in this inhibition.	Propidium	57-73	annexin A5	Homo sapiens	42-51
23748041-4	2013	Proteinase 3 induced neuronal cell death as evidenced by MTT analysis as well as propidium iodide staining, which was prevented by pretreatment with an antioxidant, N-acetyl cysteine.	Propidium	81-97	proteinase 3	Rattus norvegicus	0-12
23097025-7	2013	Furthermore, Annexin V-FITC/propidium iodide staining and the caspase-3 activity assay revealed that FABP3 gene silencing significantly promoted serum starvation-induced apoptosis in P19 cells.	Propidium	28-44	fatty acid binding protein 3	Homo sapiens	101-106
23678170-4	2013	Fluorescence-activated cell sorting following staining with annexin V or propidium iodide showed that miR-BART15-3p promoted apoptosis.	Propidium	73-89	myosin regulatory light chain interacting protein	Homo sapiens	102-105
23744355-5	2013	The majority of dying cells acquired propidium iodide positivity instantly when they became positive for Annexin V, suggesting induction of necrosis.	Propidium	37-53	annexin A5	Homo sapiens	105-114
22936601-7	2013	This result was determined by significant increases in cell death (Propidium-Iodide staining) after 6 h treatment in Snca-/- (45 % +- 2.7 SEM), relative to WT (33 % +- 3.9 SEM) cultures.	Propidium	67-83	synuclein, alpha	Mus musculus	117-121
23397952-7	2013	Treatment with TNF-alpha/CHX led to apoptotic cell death, as ascertained by annexin V/propidium iodide (PI) staining.	Propidium	86-102	tumor necrosis factor	Homo sapiens	15-24
23487582-5	2013	We found that the overexpression of human ADC increases formazan production and reduces caspase 3 activation and the numbers of FITC, hoechst, or propidium iodide positive cells in human MSCs exposed to H2O2.	Propidium	146-162	antizyme inhibitor 2	Homo sapiens	42-45
23618769-5	2013	IGF-1R siRNAs induced cell death and apoptosis were investigated using MTT assay and Annexin-V/propidium iodide (PI) double staining, respectively.	Propidium	95-111	insulin like growth factor 1 receptor	Homo sapiens	0-6
23579271-4	2013	Apoptosis assessed by annexin V-fluorescein isothiocyanate/propidium iodide staining was significantly higher in HeLa-Cx43 compared with HeLa-CTL cells.	Propidium	59-75	gap junction protein alpha 1	Homo sapiens	118-122
23354363-5	2013	Hoechst 33258 staining and Annexin V/propidium iodide double staining exhibited the typical nuclear features of apoptosis and increased the proportion of apoptotic Annexin V-positive cells in a dose-dependent manner, respectively.	Propidium	37-53	annexin A5	Homo sapiens	164-173
23238221-4	2013	In this study we confirmed that preconditioning and postconditioning with CypD inhibitor cyclosporin-A (CsA) reduced cell death after hypoxia-reoxygenation (H/R) in wild-type (WT) cardiomyocytes and HL-1 mouse cardiac cell line as measured by nuclear staining with propidium iodide.	Propidium	265-281	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	74-78
23374330-8	2013	RIP3 expressing cells frequently co-localized with propidium iodide (PI).	Propidium	51-67	receptor-interacting serine-threonine kinase 3	Rattus norvegicus	0-4
22814970-10	2013	In the optimum design, efficient fluorescence emission was obtained from the AChE-based biosensing surface after labelling with propidium, a selective fluorescent probe of the peripheral binding site of AChE.	Propidium	128-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	77-81
23073851-6	2013	The consequences of miR-203 expression on 95-D cell apoptosis were analyzed by Annexin V/propidium iodide double staining coupled with flow cytometry.	Propidium	89-105	microRNA 203a	Homo sapiens	20-27
22391555-7	2013	The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found.	Propidium	142-151	acetylcholinesterase (Cartwright blood group)	Homo sapiens	11-15
22391555-7	2013	The use of AChE-ICER in the ligands recognition assay was validated by evaluation of four known reversible inhibitors (galanthamine, tacrine, propidium, and rivastigmine), and the same order of inhibitory potencies described in the literature was found.	Propidium	142-151	cAMP responsive element modulator	Homo sapiens	16-20
22814970-10	2013	In the optimum design, efficient fluorescence emission was obtained from the AChE-based biosensing surface after labelling with propidium, a selective fluorescent probe of the peripheral binding site of AChE.	Propidium	128-137	acetylcholinesterase (Cartwright blood group)	Homo sapiens	203-207
23319321-6	2013	Moreover, knockdown of ADAM8 caused a significant increase in cisplatin-induced apoptosis assessed by annexin-V/propidium iodide double staining, accompanying with enhanced cleavage of caspase-3 and poly(ADP-ribose) polymerase.	Propidium	112-128	ADAM metallopeptidase domain 8	Homo sapiens	23-28
22669602-2	2013	Since mitochondria are key regulators in cell death pathways, we developed a simultaneous 3-parameter flow cytometric analysis that incorporates the change in mitochondrial membrane potential (Deltapsi(m)) in an Annexin-V [for phosphatidyl-serine (PS)] and propidium iodide (PI) assay system (3 parameters with 4 colours), and evaluated the apoptotic process using various haematological malignant cell lines and death triggers.	Propidium	257-273	annexin A5	Homo sapiens	212-221
23330095-2	2012	Realization of tumor cell apoptosis under conditions of in vitro culturing with Hsp27 specific inhibitor (KRIBB3) was evaluated by fluorescent microscopy with FITC-labeled annexin V and propidium iodide.	Propidium	186-202	heat shock protein family B (small) member 1	Homo sapiens	80-85
23515568-1	2013	Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS).	Propidium	227-243	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-105
23515568-1	2013	Atomic force microscopy (AFM) was applied for obtaining structural information about acetylcholinesterase (AChE) tetramer (AChE G(4)) before and after reaction with S-acetylcholine iodide (S-ACh), in the presence or absence of propidium iodide (PI), an inhibitor for peripheral anionic sites (PAS).	Propidium	227-243	acetylcholinesterase (Cartwright blood group)	Homo sapiens	107-111
23127849-8	2012	On the other hand, there was a marked increase in the TdT-mediated dUTP nick end labeling-positive and propidium iodide-labeled necrotic cells (~50%) with enhanced poly [ADP-ribose] polymerase-1 activity.	Propidium	103-119	poly(ADP-ribose) polymerase 1	Homo sapiens	164-194
22842515-4	2012	Significant NMDA-induced cytotoxicity (as measured by propidium iodide [PI] uptake) was found in the CA1 region of the hippocampus at all timepoints examined (24, 72, 120 h), an effect significantly attenuated by co-exposure to the selective NMDA receptor antagonist DL-2-Amino-5-phosphonopentanoic acid (APV), but not MDL-28170, a potent cysteine protease inhibitor.	Propidium	54-70	carbonic anhydrase 1	Homo sapiens	101-104
22885153-4	2012	Also, (PhTe)(2) significantly increased the propidium iodide (PI) positive cells in NeuN positive population without altering PI incorporation into GFAP positive cells, indicating that in vivo exposure to (PhTe)(2) provoked neuronal damage.	Propidium	44-60	RNA binding fox-1 homolog 3	Rattus norvegicus	84-88
22959464-6	2012	We analyzed the cell death via apoptosis with an annexin-V/propidium iodide assay by flow cytometry, and observed that both the percentage of apoptosis and the expression of the pro-apoptotic proteins p53 in splenocytes and thymocytes increased in a dose-related manner after PFOS treatment.	Propidium	59-75	transformation related protein 53, pseudogene	Mus musculus	201-204
22431227-8	2012	Propidium, an acetylcholinesterase inhibitor, was able to reverse the effects elicited by Abeta.	Propidium	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	14-34
22490607-6	2012	Overexpression of UCP2 significantly increased the number of cells stained with propidium iodide in cultures with acquired NMDAR channels, but failed to significantly affect that in cells exposed to A23187.	Propidium	80-96	uncoupling protein 2	Homo sapiens	18-22
22561258-4	2012	Western blotting and immunofluorescence results indicated that the expression of PI3-K and Akt was promoted in the DMH group while least apoptosis was detected in this group as analyzed by Hoechst 33342-propidium iodide co-staining.	Propidium	203-219	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
22471522-4	2012	Relative to IR alone, myeloma cells treated with IL-6 plus IR demonstrated reduced annexin/propidium iodide staining, caspase 3 activation, PARP [poly(ADP-ribose) polymerase] cleavage and mitochondrial membrane depolarization with increased clonogenic survival.	Propidium	91-107	interleukin 6	Homo sapiens	49-53
22420966-8	2012	AMP-p treatment, either before or after cell monolayers were exposed to tumor necrosis factor-alpha, protected against development of apoptosis in both cell types when assessed by annexin V and propidium iodide staining followed by flow cytometry or ligase-mediated polymerase chain reaction.	Propidium	194-210	tumor necrosis factor	Homo sapiens	72-99
22392501-3	2012	The biological changes in the BTG2-expressing cells were analyzed using growth curves, the MTT (tetrazolium) assay, propidium iodide (PI) staining, and the Transwell invasion chamber.	Propidium	116-132	BTG anti-proliferation factor 2	Homo sapiens	30-34
22246399-5	2012	Hoechst 33258 staining             and Annexin V/propidium iodide double staining exhibited the typical nuclear features             of apoptosis and increased the proportion of apoptotic Annexin V-positive cells             in a dose-dependent manner, respectively.	Propidium	49-65	annexin A5	Homo sapiens	188-197
22435755-5	2012	The dominant-negative form of mutant PKC-delta (dnPKC-delta) reduced the IFN-alpha-induced JNK1 activation, TRAIL promoter activity, loss of mitochondrial membrane potential (DeltaPsim), and increase in propidium iodide (PI) positive cells.	Propidium	203-219	protein kinase C delta	Homo sapiens	37-46
22435755-5	2012	The dominant-negative form of mutant PKC-delta (dnPKC-delta) reduced the IFN-alpha-induced JNK1 activation, TRAIL promoter activity, loss of mitochondrial membrane potential (DeltaPsim), and increase in propidium iodide (PI) positive cells.	Propidium	203-219	interferon alpha 1	Homo sapiens	73-82
22425810-11	2012	Propidium iodide staining data suggest that m-3M3FBS (20 or 50 muM) induced apoptosis in a Ca2+-independent manner.	Propidium	0-16	latexin	Homo sapiens	63-66
22306777-9	2012	Blocking LAMP-2A expression with siRNA increased the level of cleaved caspase-3 and the number of propidium iodide-positive cells after hypoxic stress regardless of whether macroautophagy could occur, whereas the administration of mycophenolic acid, a potent CMA activator, rescued hypoxia-mediated cell death.	Propidium	98-114	lysosomal-associated membrane protein 2	Mus musculus	9-16
22038141-6	2012	Flow cytometric analysis indicated that pitavastatin and the photoproduct PP4 principally induced necrosis, as revealed by the large appearance of propidium iodide-positive cells and also confirmed by the rapid drop in cellular ATP levels.	Propidium	147-163	protein phosphatase 4 catalytic subunit	Homo sapiens	74-77
22139301-5	2012	RBBP6 isoform 3 knock-down resulted in reduced G2/M cell cycle arrest whilst its over-expression resulted in increased G2/M cell cycle arrest using propidium iodide DNA staining.	Propidium	148-164	RB binding protein 6, ubiquitin ligase	Homo sapiens	0-5
20680659-4	2012	We found that nutlin-3 and HDACi cooperated to induce cell death in the p53 wild-type cell lines A549 and A2780, but not in the p53 null cell line PC-3, as assessed by Alamar Blue assay and flow cytometric analyses of propidium iodide uptake and mitochondrial depolarization.	Propidium	218-234	tumor protein p53	Homo sapiens	72-75
23326799-7	2012	The apoptotic cells were determined as annexin V-positive propidium iodide (PI)-negative cells by flow cytometry.	Propidium	58-74	annexin A5	Homo sapiens	39-48
21934697-6	2012	Importantly, administration of Akt and mTOR inhibitors together (but not of either alone) improved postinjury motor (P=0.02) and cognitive deficits (hidden platform trials, P=0.001; probe trials, P&lt;0.05), decreased propidium iodide-positive cells in CA1 and CA3 (P&lt;0.005), and unexpectedly increased p-GSK3beta in hippocampus.	Propidium	218-234	AKT serine/threonine kinase 1	Homo sapiens	31-34
21934697-6	2012	Importantly, administration of Akt and mTOR inhibitors together (but not of either alone) improved postinjury motor (P=0.02) and cognitive deficits (hidden platform trials, P=0.001; probe trials, P&lt;0.05), decreased propidium iodide-positive cells in CA1 and CA3 (P&lt;0.005), and unexpectedly increased p-GSK3beta in hippocampus.	Propidium	218-234	mechanistic target of rapamycin kinase	Homo sapiens	39-43
23071392-4	2012	This cell death is not caused by apoptosis or necrosis because caspases 3 and 9 are not activated, and the expression of annexin V/propidium iodide is not enhanced in HeLa cells after treatment.	Propidium	131-147	annexin A5	Homo sapiens	121-130
22021909-6	2012	Consistently, TSSC3 overexpression was associated with increased apoptosis assayed by annexin V/propidium iodide and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining.	Propidium	96-112	pleckstrin homology like domain family A member 2	Homo sapiens	14-19
23346404-3	2012	First, propidium iodide assays with OST cells and LM8 cells showed a decrease in cell viability after addition of ESA.	Propidium	7-23	flotillin 2	Mus musculus	114-117
21928404-3	2011	In the present study, we examined the effect of PTN on the neuronal viability of hippocampal neurons in vitro by using the immunostaining of MAP2 and permeability of propidium iodide.	Propidium	166-182	pleiotrophin	Homo sapiens	48-51
22905229-8	2012	Despite no reduction in DNA damage, MN1-expressing cells showed less apoptosis as assessed by annexin V and propidium iodide staining.	Propidium	108-124	MN1 proto-oncogene, transcriptional regulator	Homo sapiens	36-39
22792212-5	2012	FAE induced chromatin condensation and displayed an increase in apoptotic population in Annexin V-FITC/PI (Fluorescein isothiocyanate/Propidium iodide) double staining.	Propidium	134-150	annexin A5	Homo sapiens	88-97
22761954-3	2012	METHODOLOGY/PRINCIPAL FINDINGS: Using flow cytometric analysis of cells labeled with cyclin A, annexin V and propidium iodide, we describe a time and dose-dependent arrest of the cell cycle in G0/G1 phase of the cell cycle and apoptosis following extract treatment in MCF-7 (WT-p53) and MDA-MB-231 (mutant-p53) human breast cancer cell lines with a markedly reduced effect on primary human mammary epithelial cells.	Propidium	109-125	tumor protein p53	Homo sapiens	278-281
22761954-3	2012	METHODOLOGY/PRINCIPAL FINDINGS: Using flow cytometric analysis of cells labeled with cyclin A, annexin V and propidium iodide, we describe a time and dose-dependent arrest of the cell cycle in G0/G1 phase of the cell cycle and apoptosis following extract treatment in MCF-7 (WT-p53) and MDA-MB-231 (mutant-p53) human breast cancer cell lines with a markedly reduced effect on primary human mammary epithelial cells.	Propidium	109-125	tumor protein p53	Homo sapiens	306-309
22808170-10	2012	This cell shedding following myoferlin knockdown was associated with decreased expression of tight junction molecule, zonula occludens-1 (ZO-1) and increased number of cells positive for apoptotic markers Annexin V and propidium iodide.	Propidium	219-235	myoferlin	Homo sapiens	29-38
21970967-5	2011	Annexin V and propidium iodide labeling revealed cells transiently expressing GRP78 prior to injury were protected against high-concentrations of tunicamycin and glutamate within 72 h. Our findings support the hypothesis that GRP78 inhibits cell death associated with ER stress.	Propidium	14-30	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	78-83
21605080-3	2011	Annexin/PI (propidium iodide) staining showed an increase in apoptotic death of PC3 cells in the presence of GdCl3.	Propidium	12-28	chromobox 8	Homo sapiens	80-83
21970967-5	2011	Annexin V and propidium iodide labeling revealed cells transiently expressing GRP78 prior to injury were protected against high-concentrations of tunicamycin and glutamate within 72 h. Our findings support the hypothesis that GRP78 inhibits cell death associated with ER stress.	Propidium	14-30	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	226-231
21934682-16	2011	The loss of cell viability induced by SHP2 silencing could not be explained by a significant increase in apoptosis alone as demonstrated by terminal deoxyribonucleotidyl transferase-mediated nick-end labelling and propidium iodide staining.	Propidium	214-230	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	38-42
21934682-18	2011	Propidium iodide staining also showed that SHP2 silencing increases the population of glioblastoma cells in the G1 phase of the cell cycle and reduces the population of such cells in the G2/M- and S-phase.	Propidium	0-16	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	43-47
21409406-12	2011	Propidium iodide staining data suggest that diindolylmethane (25-50 muM) induced apoptosis in a concentration-dependent manner.	Propidium	0-16	latexin	Homo sapiens	68-71
21679745-10	2011	Positive DNA staining (propidium iodide) of HDLM-2 cells treated with ECP indicated cell death by necrosis.	Propidium	23-39	ribonuclease A family member 3	Homo sapiens	70-73
21752338-5	2011	In slice cultures, thrombin-induced a drastic increase in propidium iodide fluorescence indicating necrotic cell death in the cortical region, and robust shrinkage of the striatal tissue.	Propidium	58-74	coagulation factor II	Rattus norvegicus	19-27
21917150-5	2011	Dlx-2 short hairpin RNA (shRNA) inhibited metabolic stress-induced increase in propidium iodide-positive cell population and HMGB1 and lactate dehydrogenase (LDH) release, indicating the important role(s) of Dlx-2 in metabolic stress-induced necrosis.	Propidium	79-95	distal-less homeobox 2	Homo sapiens	0-5
21620685-7	2011	RESULTS: 77.5% skin cells in Sharpin(cpdm) mice were functionally apoptotic and dead cells, compared to only 18.1% unhealthy skin cells in wildtype mice, indicated by annexin-V/propidium iodide FACS analysis.	Propidium	177-193	SHANK-associated RH domain interacting protein	Mus musculus	29-36
21621464-7	2011	In addition, there were more Annexin V and propidium iodide positive monocytes in the CD16(+) subset infected with live M. tuberculosis at 24 h than CD16(-) monocytes.	Propidium	43-59	Fc gamma receptor IIIa	Homo sapiens	86-90
21641039-8	2011	Exposure of ART2.2-transgenic T cells to low, submicromolar concentrations of NAD caused cell membrane alterations including uptake of propidium iodide, externalization of phosphatidylserine, and shedding of CD62L, while ART2.2-transgenic B cells were resistant to NAD.	Propidium	135-151	ADP-ribosyltransferase 2b	Mus musculus	12-18
21463664-8	2011	In addition, double immunolabeling showed that the increased punctate LC3-II dots colocalizing with Propidium Iodide (PI)-stained nuclei at 24 h after injury, were partially inhibited by 3-MA pretreatment.	Propidium	100-116	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	70-73
21453436-4	2011	The extent of CA1 cell injury was assessed 3 h after the end of 7 min of OGD by propidium iodide staining.	Propidium	80-96	carbonic anhydrase 1	Rattus norvegicus	14-17
21482132-6	2011	In apoptotic assay cells positive for Annexin V were stained more brightly with the dyes B9, B11 and B13 than with propidium iodide.	Propidium	115-131	annexin A5	Homo sapiens	38-47
21231855-13	2011	To identify the target(s) of GSK-3beta inhibition during differentiation into MK lineage cells, we performed a differential gene expression study and subsequent pathway analysis of the large (MK)-sized CD41 (+)/propidium iodide (-) cells cultured in TWS119 (+/-) for 3 days.	Propidium	211-227	glycogen synthase kinase 3 beta	Homo sapiens	29-38
21490929-11	2011	A propidium iodide uptake assay suggested that the inhibitory activity of mASAL might be associated with the alteration of the membrane permeability of the fungus.	Propidium	2-18	argininosuccinate lyase	Mus musculus	74-79
20665705-8	2011	Furthermore, depletion of ApoL2 facilitated IFN-gamma-induced membrane damage and chromatin condensation as observed in Hoechst and propidium iodide-double staining and in transmission electron microscopy, and DNA fragmentation using a DNA laddering assay, in a caspase-dependent manner.	Propidium	132-148	apolipoprotein L2	Homo sapiens	26-31
20665705-8	2011	Furthermore, depletion of ApoL2 facilitated IFN-gamma-induced membrane damage and chromatin condensation as observed in Hoechst and propidium iodide-double staining and in transmission electron microscopy, and DNA fragmentation using a DNA laddering assay, in a caspase-dependent manner.	Propidium	132-148	interferon gamma	Homo sapiens	44-53
21327870-6	2011	Interestingly, a significant fraction of FUS expressing yeast cells stained by propidium iodide were without detectable protein aggregates, suggesting that membrane impairment and cellular damage caused by FUS expression may occur before protein aggregates become microscopically detectable and that aggregate formation might protect cells from FUS-mediated cytotoxicity.	Propidium	79-95	FUS RNA binding protein	Homo sapiens	41-44
21362377-6	2011	The amount of dead INS-1 cells was determined by HO342 and propidium iodide staining.	Propidium	59-75	insulin 1	Rattus norvegicus	19-24
22654166-4	2011	At initial time points following the induction of YLR162W expression, cell cycle progression was inhibited with the emergence of a distinct sub-G1 peak indicative of apoptotic cells, mitochondrial membrane potential was also decreased along with an increase in the fraction of cells permeable to propidium iodide; none of the above was further affected by CoCl(2).	Propidium	296-312	uncharacterized protein	Saccharomyces cerevisiae S288C	50-57
21371463-5	2011	By using Annexin V-FITC/propidium iodide double staining, we found that leptin expressed a dose-dependent protective effect against gentamicin-induced apoptosis in rat renal tubular cells (NRK-52E) within 24h.	Propidium	24-40	leptin	Rattus norvegicus	72-78
21232596-11	2011	Propidium iodide staining suggests that DADS (500 muM) induced apoptosis in a Ca(2+)-independent manner.	Propidium	0-16	latexin	Homo sapiens	50-53
20708296-4	2010	TIP47, but not its truncated form, t-TIP47, decreased taxol-induced cell death as determined by propidium iodide and fluorescent Annexin V staining.	Propidium	96-112	perilipin 3	Mus musculus	0-5
21090615-3	2010	The click-chemistry inhibitor TZ2PA6 links the active center ligand, tacrine, to the peripheral site ligand, propidium, through a biorthogonal reaction of an acetylene and an azide that forms either a syn1 or an anti1 triazole.	Propidium	109-118	synapsin I	Mus musculus	201-205
21172031-7	2010	Cell death in the slice CA1 region was assessed by propidium iodide staining of dead cells.	Propidium	51-67	carbonic anhydrase 1	Mus musculus	24-27
21605496-6	2011	In contrast, exposure of A431 (A27B(PTPalpha)) cells to 2.0 mM SNP produced an increase in the release of lactate dehydrogenase and enhanced incorporation of propidium iodide.	Propidium	158-174	protein phosphatase 2 phosphatase activator	Homo sapiens	36-44
20851574-5	2010	A Cx43 mimetic peptide, applied during either the BMC treatment or recovery periods, produced concentration- and exposure time-dependent neuroprotection, as measured by propidium iodide uptake at the end of the recovery period.	Propidium	169-185	gap junction protein alpha 1	Homo sapiens	2-6
20877573-6	2010	Non-adherent HCT116 and HT29 colorectal carcinoma cells expressing CXCL12 exhibited enhanced anoikis sensitivity by propidium iodide staining, caspase activity assays, and immunoblot compared to GFP control cells.	Propidium	116-132	C-X-C motif chemokine ligand 12	Homo sapiens	67-73
21224539-4	2010	Next, using HL60 cells, the apoptosis-inducing effect of PSK was examined using Annexin-V/Propidium iodide immunostaining and DNA fragmentation.	Propidium	90-106	TAO kinase 2	Homo sapiens	57-60
20678483-3	2010	In the present study, we show that the integrin alpha8 shRNA-mediated knockdown in HIECs leads to a decrease in anoikis susceptibility under cell suspension culture conditions, marked by a reduction in PARP cleavage and propidium iodide incorporation.	Propidium	220-236	integrin subunit alpha 8	Homo sapiens	39-54
20687538-9	2010	The cytotoxic mechanism of PRA was revealed as a type of necrotic lysis by FACs analysis with propidium iodide (PI) staining.	Propidium	94-110	S100 calcium binding protein A6	Homo sapiens	27-30
20382751-4	2010	In the present work, we first showed that in vitro Bcl-2 can rescue murine pulmonary epithelial cells (MLE12) from oxygen-induced cell apoptosis, as shown by analysis of LDH release, annexin V/propidium staining, and caspase-3 activity.	Propidium	193-202	B cell leukemia/lymphoma 2	Mus musculus	51-56
21793328-9	2010	Moreover, both caspase-9 activity and annexin V/propidium iodine staining demonstrated that Tbeta4 only protected BCE cells from low-dose UVB-induced apoptosis but not high-dose UVB-induced necrosis.	Propidium	48-64	thymosin beta-4	Bos taurus	92-98
20649598-3	2010	EXPERIMENTAL APPROACH: Cytotoxicity of CA-4 was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, propidium iodide (PI) staining assay and clonogenic survival assay.	Propidium	134-150	carbonic anhydrase 4	Mus musculus	39-43
20632941-2	2010	Ca2+ at concentrations of 1-100 microM increased and at a concentration of 1 mM prevented the CN(-)-induced destruction of the nucleus in GC, disrupting the permeability barrier of GC plasma membrane for propidium iodide (PI).	Propidium	204-220	carbonic anhydrase 2	Homo sapiens	0-3
20571735-5	2010	The effect of LASS2 gene on apoptosis was evaluated with Annexin-V/FITC and propidium iodide (PI) by flow cytometry.	Propidium	76-92	ceramide synthase 2	Homo sapiens	14-19
20339095-4	2010	TLR9-CpG ODN ligation-induced apoptosis of B-CLL cells is confirmed by viable cell counts, annexin V/propidium iodide and tetramethyl-rhodamine ethylester staining, Western blots of the activation, and cleaved caspases and poly (ADP-ribose) polymerase.	Propidium	101-117	toll like receptor 9	Homo sapiens	0-4
20333468-5	2010	Annexin V and propidium iodide (Annexin V/PI) staining demonstrated a dose and time-dependent relationship in which PDTC enhanced the percentage of IR-induced apoptotic/necrotic NMSC.	Propidium	14-30	annexin A5	Mus musculus	32-44
20226231-3	2010	After an 18 h KA (5 microM) treatment, significantly neuronal death was detected in the CA3 region using propidium iodide staining.	Propidium	105-121	carbonic anhydrase 3	Homo sapiens	88-91
20512470-6	2010	Furthermore, stable inhibition of NRF2 sensitized OV90 cells were seen following doxorubicin treatment as shown by the analysis with MTT assay and propidium iodide-fluorescence-activated cell sorting.	Propidium	147-163	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
20006589-4	2010	Using microspectrofluorimetry, we demonstrated that Asc/Men-generated oxidative stress was associated with a slow and moderate increase in [Ca2+](c), largely preceding permeation of propidium iodide, and thus cell death.	Propidium	182-198	PYD and CARD domain containing	Homo sapiens	52-55
20136436-4	2010	TSL-1-induced apoptosis was confirmed by cell morphology, sub-G(1) peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining.	Propidium	131-147	TSL	Homo sapiens	0-3
20377305-6	2010	Quantitative densitometric image analysis of propidium iodide uptake in hippocampal regions CA1, CA3 and DG, showed that, after exposure to 10microM NMDA for 24 hours, GK11 was the most potent of the three drugs, with an IC50 of about 50nM and complete protection at 250nM.	Propidium	45-61	carbonic anhydrase 1	Homo sapiens	92-95
19931600-9	2010	Flow cytometry experiments showed that NGF-differentiated PC12 cells in presence of zinc were positive for propidium iodide but not for annexin-V labeling.	Propidium	107-123	nerve growth factor	Rattus norvegicus	39-42
20007452-5	2010	Cell cycle analysis by flow cytometry of propidium iodide-stained cells showed a relatively higher percentage of Cav-2 KO ECs in S and G(2)/M and lower percentage in G(o)/G(1) phases of cell cycle relative to their WT counterparts.	Propidium	41-57	caveolin 2	Mus musculus	113-118
19281492-2	2010	PMN elastase caused a time- and concentration-dependent (up to a elastase concentration of 0.5 microg/mL) externalization of phosphatidylserine and intercalation of propidium iodide on human spermatozoa.	Propidium	165-181	elastase, neutrophil expressed	Homo sapiens	0-12
19281492-2	2010	PMN elastase caused a time- and concentration-dependent (up to a elastase concentration of 0.5 microg/mL) externalization of phosphatidylserine and intercalation of propidium iodide on human spermatozoa.	Propidium	165-181	elastase, neutrophil expressed	Homo sapiens	4-12
19910452-5	2010	MDA-7/IL-24 reduced MCL-1 and BCL-XL and increased BAX levels via PERK signaling; cell-killing was mediated via the intrinsic pathway, and cell killing was primarily necrotic as judged using Annexin V/propidium iodide staining.	Propidium	201-217	interleukin 24	Homo sapiens	0-5
19910452-5	2010	MDA-7/IL-24 reduced MCL-1 and BCL-XL and increased BAX levels via PERK signaling; cell-killing was mediated via the intrinsic pathway, and cell killing was primarily necrotic as judged using Annexin V/propidium iodide staining.	Propidium	201-217	interleukin 24	Homo sapiens	6-11
20137150-4	2010	By using U937 cell line as in vitro model, effect of G-CSF on cell cycle was determined by propidium iodide staining method.	Propidium	91-107	colony stimulating factor 3	Homo sapiens	53-58
19901022-7	2010	Despite the release of PMIP, SOUL facilitated predominantly necrotic cell death, as revealed by annexin V and propidium iodide staining.	Propidium	110-126	heme binding protein 2	Homo sapiens	29-33
19752309-8	2009	Complement activation was measured by quantifying the number of green fluorescent protein-AQP4-transfected HEK 293 cells permeable to the viability dye propidium iodide after exposure to patient serum and active complement.	Propidium	152-168	aquaporin 4	Homo sapiens	90-94
19856923-3	2009	At submicromolar concentration, they inhibit AChE and butyrylcholinesterase (BuChE) of human origin, displace the binding of propidium iodide from the PAS of AChE, and could thus inhibit Abeta aggregation promoted by AChE.	Propidium	125-141	acetylcholinesterase (Cartwright blood group)	Homo sapiens	158-162
19856923-3	2009	At submicromolar concentration, they inhibit AChE and butyrylcholinesterase (BuChE) of human origin, displace the binding of propidium iodide from the PAS of AChE, and could thus inhibit Abeta aggregation promoted by AChE.	Propidium	125-141	acetylcholinesterase (Cartwright blood group)	Homo sapiens	158-162
19759279-6	2009	Cytotoxicity was assessed by fluorescent microscopy and quantification of propidium iodide (PI) uptake in the pyramidal cell layers of the CA1 and CA3 regions and the granule cell layer of the dentate gyrus (DG).	Propidium	74-90	carbonic anhydrase 1	Rattus norvegicus	139-142
19887553-8	2009	The induction of apoptosis after PLK1 silencing was confirmed by increased p-H2AX, propidium iodide uptake, and chromatin condensation, as well as caspase-3 and poly(ADP-ribose) polymerase cleavage.	Propidium	83-99	polo like kinase 1	Homo sapiens	33-37
19616548-2	2009	Here we show that the cyclin-dependent kinase inhibitor (CDKi) R-roscovitine efficiently and rapidly induces human eosinophil apoptosis using flow cytometric analysis of annexin-V/propidium iodide staining, morphological analysis by light microscopy, transmission electron microscopy and Western immunoblotting for caspase-3 cleavage.	Propidium	180-196	cyclin dependent kinase inhibitor 3	Homo sapiens	22-55
19616548-2	2009	Here we show that the cyclin-dependent kinase inhibitor (CDKi) R-roscovitine efficiently and rapidly induces human eosinophil apoptosis using flow cytometric analysis of annexin-V/propidium iodide staining, morphological analysis by light microscopy, transmission electron microscopy and Western immunoblotting for caspase-3 cleavage.	Propidium	180-196	cyclin dependent kinase inhibitor 3	Homo sapiens	57-61
19661297-6	2009	The cell cycle and expression of cyclin A were assayed after staining with propidium iodide and cyclin A-fluorescein isothiocyanate.	Propidium	75-91	cyclin A2	Homo sapiens	33-41
19439413-10	2009	Thrombin-elicited ATP release was accompanied by an enhanced cellular uptake of propidium iodide in a Ca(2+)- and ROCK-dependent manner and was inhibited by connexin/pannexin hemichannel blockers.	Propidium	80-96	coagulation factor II, thrombin	Homo sapiens	0-8
19439413-10	2009	Thrombin-elicited ATP release was accompanied by an enhanced cellular uptake of propidium iodide in a Ca(2+)- and ROCK-dependent manner and was inhibited by connexin/pannexin hemichannel blockers.	Propidium	80-96	ATPase phospholipid transporting 8A2	Homo sapiens	18-21
19422385-6	2009	The extent of CA1 cell injury was assessed 3 h after the end of 7 min OGD by propidium iodide.	Propidium	77-93	carbonic anhydrase 1	Rattus norvegicus	14-17
19307427-9	2009	Furthermore, in the presence or absence of FSH, TGFB1 increased the proportion of cells in apoptosis measured by propidium iodide staining and flow cytometry and confirmed by increased levels of cleaved caspase-3 (P&lt;0.05).	Propidium	113-129	transforming growth factor beta 1	Bos taurus	48-53
19224577-4	2009	NTR1 significantly inhibited the increased number of cells positive to propidium iodide (PI) staining, increase of intracellular free Ca(2+) ions, overproduction of intracellular reactive oxygen species, and depolarization of mitochondrial membrane potential in cultured neurons exposed to Glu, in addition to blocking decreased Bcl-2 and increased Bax expression levels.	Propidium	71-87	neurotensin receptor 1	Mus musculus	0-4
19235896-4	2009	Preincubation with the caspase-9 inhibitor z-LEHD-fmk, the caspase-3 inhibitor z-DEVD-fmk, or the specific pan-caspase inhibitor Q-VD-oph decreased the percentage of propidium iodide-positive neurons (52.5% +/- 3.1%, 39.4% +/- 3.5%, 44.6% +/- 3%, respectively, vs. 65% +/- 3% in glutamate + vehicle).	Propidium	166-182	caspase 9	Homo sapiens	23-32
19235896-4	2009	Preincubation with the caspase-9 inhibitor z-LEHD-fmk, the caspase-3 inhibitor z-DEVD-fmk, or the specific pan-caspase inhibitor Q-VD-oph decreased the percentage of propidium iodide-positive neurons (52.5% +/- 3.1%, 39.4% +/- 3.5%, 44.6% +/- 3%, respectively, vs. 65% +/- 3% in glutamate + vehicle).	Propidium	166-182	caspase 3	Homo sapiens	59-68
19428112-4	2009	Preconditioning of neuronal cells with BDNF (100 ng/ml for 8h) attenuated 3-NP toxicity (2.5 mM for additional 24h) based on Hoechst and propidium iodide (PI) staining.	Propidium	137-153	brain-derived neurotrophic factor	Rattus norvegicus	39-43
19347028-8	2009	Using the property of p53, we can deliver the chemical (propidium iodine) into K-Ras mutated cells selectively.	Propidium	56-72	tumor protein p53	Homo sapiens	22-25
19347028-8	2009	Using the property of p53, we can deliver the chemical (propidium iodine) into K-Ras mutated cells selectively.	Propidium	56-72	KRAS proto-oncogene, GTPase	Homo sapiens	79-84
19413654-10	2009	Cd2+-induced apoptosis was demonstrated by propidium iodide.	Propidium	43-59	CD2 molecule	Canis lupus familiaris	0-3
19270112-7	2009	In addition, these cells exhibited an early onset of cell death, as judged from propidium iodide staining, suggesting that CDC53 is an essential gene in C. albicans.	Propidium	80-96	cullin CDC53	Saccharomyces cerevisiae S288C	123-128
19308922-6	2009	At sub-micromolar concentrations they efficiently displace the binding of propidium iodide from the PAS and could thus inhibit A beta peptide aggregation promoted by AChE.	Propidium	74-90	amyloid beta precursor protein	Homo sapiens	127-133
19308922-6	2009	At sub-micromolar concentrations they efficiently displace the binding of propidium iodide from the PAS and could thus inhibit A beta peptide aggregation promoted by AChE.	Propidium	74-90	acetylcholinesterase (Cartwright blood group)	Homo sapiens	166-170
19468252-7	2009	Exposure of human fetal brain neurons to oxygen-glucose deprivation also induced BTG2 expression in the cytoplasm and perinuclear regions of cells staining positive for propidium iodide (a marker of nuclear damage).	Propidium	169-185	BTG anti-proliferation factor 2	Homo sapiens	81-85
19041363-6	2009	Moreover, Z-VAD-FMK decreased the apoptotic cells, whereas the number of propidium iodide (PI)-positive cells with partial chromatin condensation was reduced by Nec-1, an inhibitor of receptor interacting protein (RIP-1).	Propidium	73-89	proprotein convertase subtilisin/kexin type 1	Mus musculus	161-212
18942742-6	2009	Primary mouse astrocytes were found to take up the P2X7R permeant dyes YO-PRO-1 (YP) and propidium iodide in absence of any added ligands.	Propidium	89-105	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	51-56
19370057-6	2009	Assessment of cells after PTH treatment by use of propidium iodide showed that the hormone increased the number of red-stained (dead) cells (178%, 5 days).	Propidium	50-66	parathyroid hormone	Homo sapiens	26-29
19063950-6	2009	Seven/fourteen days after ischemia, intracisternally administered propidium iodide labeled numerous necrotic cells in the frontoparietal cortex, which were mostly NeuN-positive, but were not immunolabeled with astrocytic markers (GFAP and S100), and showed neuronal morphology with hematoxylin-eosin staining, indicating that the model successfully induced ischemic injury limited to neurons.	Propidium	66-82	RNA binding fox-1 homolog 3	Homo sapiens	163-167
19063950-6	2009	Seven/fourteen days after ischemia, intracisternally administered propidium iodide labeled numerous necrotic cells in the frontoparietal cortex, which were mostly NeuN-positive, but were not immunolabeled with astrocytic markers (GFAP and S100), and showed neuronal morphology with hematoxylin-eosin staining, indicating that the model successfully induced ischemic injury limited to neurons.	Propidium	66-82	glial fibrillary acidic protein	Homo sapiens	230-234
19063950-6	2009	Seven/fourteen days after ischemia, intracisternally administered propidium iodide labeled numerous necrotic cells in the frontoparietal cortex, which were mostly NeuN-positive, but were not immunolabeled with astrocytic markers (GFAP and S100), and showed neuronal morphology with hematoxylin-eosin staining, indicating that the model successfully induced ischemic injury limited to neurons.	Propidium	66-82	S100 calcium binding protein A1	Homo sapiens	239-243
19243318-4	2009	METHODS: Using cultured rat dopaminergic neuroblasts (N27 line), tPA-induced cytotoxicity was quantitated by an MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay and flow cytometry using propidium iodide DNA staining.	Propidium	210-226	plasminogen activator, tissue type	Rattus norvegicus	65-68
19110660-3	2009	Apoptosis of CD4 and CD8 T lymphocytes and naive and memory subpopulations was determined by flow cytometry using 7-amino-actinomycin D (7AAD) and propidium iodide (PI).	Propidium	147-163	CD4 molecule	Homo sapiens	13-16
18592376-2	2009	Assessed with propidium iodide and lactate dehydrogenase (LDH) leakage, neurodamage from ethanol (6 days 100 mM ethanol with four withdrawal periods) was prevented by the PLA2 pan-inhibitor, mepacrine.	Propidium	14-30	phospholipase A2 group IB	Rattus norvegicus	171-175
19041363-6	2009	Moreover, Z-VAD-FMK decreased the apoptotic cells, whereas the number of propidium iodide (PI)-positive cells with partial chromatin condensation was reduced by Nec-1, an inhibitor of receptor interacting protein (RIP-1).	Propidium	73-89	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	214-219
19032871-3	2008	The apoptosis of FRNK-induced HSC was examined by annexin-V/propidium iodide double-labeled flow cytometry (FCM), gel electrophoresis and transmission electron microscopy.	Propidium	60-76	protein tyrosine kinase 2	Homo sapiens	17-21
19593703-4	2009	The effects of CD24 knockdown in SKOV3 cells in vitro, including cell viability and apoptosis, were determined using methyl thiazolyl blue tetrazolium bromide (MTT), flow cytometry and propidium iodide (PI) staining assays.	Propidium	185-201	CD24 molecule	Homo sapiens	15-19
18728678-4	2009	Preexposure to LPS immediately before OGD increased propidium iodide-determined cell death in regions CA1, CA3, and dentate gyrus from 4 up to 48 h after OGD (P&lt;0.001).	Propidium	52-68	carbonic anhydrase 1	Mus musculus	102-105
18728678-4	2009	Preexposure to LPS immediately before OGD increased propidium iodide-determined cell death in regions CA1, CA3, and dentate gyrus from 4 up to 48 h after OGD (P&lt;0.001).	Propidium	52-68	carbonic anhydrase 3	Mus musculus	107-110
19099627-3	2008	Cell cycle changes of A3 cells treated with different concentrations of G-CSF for 48 hours were examined by propidium iodide staining method.	Propidium	108-124	colony stimulating factor 3	Homo sapiens	72-77
18786620-10	2008	In cultures transfected with green fluorescent protein (GFP)-calpastatin plasmid, calpastatin overexpression (indicated by GFP-labeling) led to inhibition in sAbeta-induced membrane propidium iodide (PI) permeability, whereas non-transfected, GFP-unlabeled cells exhibited PI permeability.	Propidium	182-198	calpastatin	Rattus norvegicus	61-72
18786620-10	2008	In cultures transfected with green fluorescent protein (GFP)-calpastatin plasmid, calpastatin overexpression (indicated by GFP-labeling) led to inhibition in sAbeta-induced membrane propidium iodide (PI) permeability, whereas non-transfected, GFP-unlabeled cells exhibited PI permeability.	Propidium	182-198	calpastatin	Rattus norvegicus	82-93
18985819-4	2008	The effect of MK on anti-apoptotic activity of HepG2 cells was studied with FITC-conjugated annexin V and propidium iodide PI double staining through FACS assay.	Propidium	106-122	midkine	Homo sapiens	14-16
18468882-1	2008	We developed a dual piezoelectric/amperometric sensor for the detection of two unrelated analytes in one experiment that uses propidium to anchor acetylcholinesterases (AChE) at the surface.	Propidium	126-135	acetylcholinesterase (Cartwright blood group)	Homo sapiens	169-173
18555981-6	2008	In this communication we describe rationale for using purified recombinant Drosophila AChE as a template for in situ reaction of tacrine and propidium based libraries of acetylene and azide building blocks.	Propidium	141-150	Acetylcholine esterase	Drosophila melanogaster	86-90
18554319-4	2008	We developed recombinant forms of clusterin and examined their effect on propidium iodide uptake, neuronal and synaptic markers as well as electrophysiological recordings in hippocampal slice cultures from Clu-/- and WT mice subjected to oxygen-glucose deprivation (OGD).	Propidium	73-89	clusterin	Mus musculus	34-43
18619545-3	2008	Hippocampal slices from Nrf2 knockout mice exhibited increased oxidative stress and cell death compared to those of control mice in response to kainate, as determined with the redox sensitive probes 2,7-dichlorodihydrofluorescein diacetate (H(2)DCFAC) and propidium iodide and lactate dehydrogenase release, respectively, therefore demonstrating a role of Nrf2 in antioxidant protection against excitotoxicity.	Propidium	256-272	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-28
18606174-3	2008	Both protocols attenuated CA1 neuronal injury, as revealed 24h later by measuring the intensity of propidium iodide fluorescence in this region.	Propidium	99-115	carbonic anhydrase 1	Rattus norvegicus	26-29
18554319-5	2008	WT mice displayed a marked up-regulation of clusterin associated with electrophysiological deficits and dramatic increase of propidium iodide uptake 5 days post-OGD.	Propidium	125-141	clusterin	Mus musculus	44-53
18524973-5	2008	We demonstrate here that LL-37 affects neutrophil lifespan by the pathway of secondary necrosis, rapidly converting annexin V-positive (AV(+)), propidium iodide-negative (PI(-); apoptotic) cells into PI(+) (necrotic) cells with the release of IL-8, IL-1R antagonist, ATP, and intact granules.	Propidium	144-160	cathelicidin antimicrobial peptide	Homo sapiens	25-30
18648551-9	2008	This impaired production could be related to C5a-induced initiation of apoptosis as defined by binding of Annexin V and Propidium Iodine to PC12 cells.	Propidium	120-136	complement C5	Rattus norvegicus	45-48
18641702-4	2008	Results obtained from flow cytometry using the membrane exclusion dye propidium iodide suggested that Hsp12p helped maintain plasma membrane integrity during desiccation.	Propidium	70-86	lipid-binding protein HSP12	Saccharomyces cerevisiae S288C	102-108
18260127-2	2008	Prdx6 null AEC II exposed to H(2)O(2) showed concentration-dependent cytotoxicity indicated by decreased "live/dead" cell ratio, increased propidium iodide (PI) staining, increased annexin V binding, increased DNA fragmentation by TUNEL assay, and increased lipid peroxidation by diphenylpyrenylphosphine (DPPP) fluorescence.	Propidium	139-155	peroxiredoxin 6	Mus musculus	0-5
18502514-3	2008	In propidium iodide (PI) uptake and annexin V labeling, A beta 25-35-induced neuronal damage dramatically increased in a concentration dependent manner, indicating both types of cell death.	Propidium	3-19	amyloid beta precursor protein	Homo sapiens	56-62
18375381-5	2008	Knockdown of CIBZ by small interfering RNA in C2C12 cells induced apoptosis, as determined by an increase of annexin V/propidium iodide labeling, activation of caspase-3, and cleavage of poly(ADP-ribose) polymerase.	Propidium	119-135	zinc finger and BTB domain containing 38	Mus musculus	13-17
18566240-4	2008	Hoechst 33258 staining and Annexin V/propidium iodide double staining exhibited the typical nuclear features of apoptosis and increased the proportion of apoptotic Annexin V-positive cells in a dose-dependent manner, respectively.	Propidium	37-53	annexin A5	Homo sapiens	164-173
18271940-8	2008	We observed cell cycle arrest and apoptotic induction in the RUNX1 chimera-expressing cells by the propidium iodide staining.	Propidium	99-115	RUNX family transcription factor 1	Homo sapiens	61-66
18295794-4	2008	Here, using electron cryomicroscopy of EmrE two-dimensional crystals we have determined projection structures of EmrE bound to three structurally different planar drugs, ethidium, propidium and dequalinium.	Propidium	180-189	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	113-117
18176311-8	2008	MEASUREMENTS AND MAIN RESULTS: Posttraumatic cell death was quantified at 12, 24, or 48 hrs after injury by measuring propidium iodide fluorescence in the selectively vulnerable CA1 hippocampal area.	Propidium	118-134	carbonic anhydrase 1	Homo sapiens	178-181
18295794-1	2008	EmrE is a Small Multidrug Resistance transporter (SMR) family member that mediates counter transport of protons and hydrophobic cationic drugs such as tetraphenylphosphonium (TPP+), ethidium, propidium and dequalinium.	Propidium	192-201	single-pass membrane protein with aspartate rich tail 1	Homo sapiens	0-4
18182160-6	2008	Nuclear staining with Hoechst 33258 and fluorescence-activated cell sorting of propidium iodide-stained cells showed that TNF-alpha induced apoptosis of EC.	Propidium	79-95	tumor necrosis factor	Homo sapiens	122-131
17870167-3	2008	TUNEL and propidium iodide permeability assays demonstrated that PEDF dose- and time-dependently induces both apoptosis and necrosis of THP-1 macrophages while inducing the cleavages of procaspase-9, -3, the release of cytochrome c and the overexpression of p53.	Propidium	10-26	serpin family F member 1	Homo sapiens	65-69
17991734-3	2008	In this report, we demonstrate that Ad-MMP-9 induced apoptosis in DAOY cells as determined by propidium iodide and terminal deoxynucleotidyltransferase-mediated nick end labeling staining.	Propidium	94-110	matrix metallopeptidase 9	Homo sapiens	39-44
18006502-4	2008	Blocking Raf-1 activity using a specific Raf-1 inhibitor or dominant-negative Raf-1 mutants led to a time- and dose-dependent increase in cell death, assessed by real-time imaging of propidium iodide incorporation, TUNEL, PCR-enhanced DNA laddering, and Caspase-3 cleavage.	Propidium	183-199	v-raf-leukemia viral oncogene 1	Mus musculus	9-14
18006502-4	2008	Blocking Raf-1 activity using a specific Raf-1 inhibitor or dominant-negative Raf-1 mutants led to a time- and dose-dependent increase in cell death, assessed by real-time imaging of propidium iodide incorporation, TUNEL, PCR-enhanced DNA laddering, and Caspase-3 cleavage.	Propidium	183-199	v-raf-leukemia viral oncogene 1	Mus musculus	41-46
18006502-4	2008	Blocking Raf-1 activity using a specific Raf-1 inhibitor or dominant-negative Raf-1 mutants led to a time- and dose-dependent increase in cell death, assessed by real-time imaging of propidium iodide incorporation, TUNEL, PCR-enhanced DNA laddering, and Caspase-3 cleavage.	Propidium	183-199	v-raf-leukemia viral oncogene 1	Mus musculus	41-46
18046491-5	2007	The results from Annexin V-propidium iodide staining revealed that phe a, phe b, pho a and pho b could induce cell death in HuH-7 cells predominantly via a necrotic process.	Propidium	27-43	annexin A5	Homo sapiens	17-26
17953712-4	2008	Annexin-V/propidium iodide staining analysis revealed hypoxia or forced HIF-1 alpha expression reduced apoptosis by 24% or 18% in SGC7901 cells (P &lt; 0.05).	Propidium	10-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-83
17988655-8	2007	Subsequent cell death in the CA1 region was quantified using propidium iodide staining.	Propidium	61-77	carbonic anhydrase 1	Rattus norvegicus	29-32
18025171-10	2007	FasL elicited apoptosis (as detected by annexin-V/propidium iodide costaining) as early as 24 h after T cell activation, suggesting that some coordinate signaling might be capacitating the Fas receptor.	Propidium	50-66	Fas ligand	Homo sapiens	0-4
20020892-6	2008	D-GalN was more potent to induce hepatocyte apoptosis and necrosis during 24 to 48 than 0 to 24 hours as evidenced morphologically (Annexin V/propidium iodide staining) and biochemically (caspase-3-like activity, alanine-aminotransferase leakage, MTT test).	Propidium	142-158	galanin and GMAP prepropeptide	Rattus norvegicus	2-6
18046491-5	2007	The results from Annexin V-propidium iodide staining revealed that phe a, phe b, pho a and pho b could induce cell death in HuH-7 cells predominantly via a necrotic process.	Propidium	27-43	MIR7-3 host gene	Homo sapiens	124-129
17021346-11	2007	Treatment with 2 microM leptin AS increased the number of apoptotic cells 60 times, as assessed by annexin V-fluorescein isothiocyanate/propidium iodide staining, and the caspase-3 activity was increased more than 2 fold.	Propidium	136-152	leptin	Homo sapiens	24-30
17537537-11	2007	For incubation times longer than 1 h, propidium iodide staining showed that cells treated with DAB 2.0 and 3.0 had a higher subG1 phase (indicative of apoptosis) than did untreated cells.	Propidium	38-54	DAB adaptor protein 2	Homo sapiens	95-100
17524372-4	2007	Exposure of slice cultures to NMDA for 24-h produced increases in uptake of the non-vital fluorescent marker propidium iodide (PI) of 150-500% above control levels, most notably, in the CA1 region pyramidal cell layer.	Propidium	109-125	carbonic anhydrase 1	Rattus norvegicus	186-189
17363173-10	2007	OGD or glutamate (3.5-5.0 mM) damaged CA1 pyramidal neurons as assessed by propidium iodide (PI) fluorescence.	Propidium	75-91	carbonic anhydrase 1	Rattus norvegicus	38-41
17532820-7	2007	Furthermore, the caspase-3 expression was determined by a immunocytochemical staining method before and after treatment with rosiglitazone and 15-d-PGJ2 for 48 h. The cell cycles were measured by flow cytometric analysis using propidium iodide (PI).	Propidium	227-243	caspase 3	Homo sapiens	17-26
17188441-2	2007	We have observed that high concentration of extracellular ATP (&gt;1mM), which activates P2X(7) receptor, produced cell shrinkage an increase in the number of events in the sub-G(0)/G(1) region of the cellular cycle and annexin-V/propidium iodide label, which characterizes the apoptotic cell death.	Propidium	230-246	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	89-104
17950092-11	2007	Annexin V-FITC/propidium iodide revealed apoptosis in infected cells following treatment with ganciclovir.	Propidium	15-31	annexin A5	Rattus norvegicus	0-9
17570061-6	2007	Immunofluorescent and propidium iodide labeling detected caspase-3-p20 fragment in apoptotic cells, indicating activation of caspase-3 as well.	Propidium	22-38	caspase 3	Rattus norvegicus	57-66
17570061-6	2007	Immunofluorescent and propidium iodide labeling detected caspase-3-p20 fragment in apoptotic cells, indicating activation of caspase-3 as well.	Propidium	22-38	heat shock protein family B (small) member 6	Rattus norvegicus	67-70
17904792-8	2007	The proapoptotic effects of the FAS inhibitors were further confirmed using confocal microscopy with annexin-V FITC and propidium iodide staining.	Propidium	120-136	fatty acid synthase	Homo sapiens	32-35
17512223-2	2007	To investigate the nature of this PKC-induced inhibition of cell growth, wildtype and bovine PKCalpha-expressing yeast cells were examined by flow cytometry and by fluorescence microscopy after staining with propidium iodide.	Propidium	208-224	protein kinase C alpha	Bos taurus	34-37
17618031-4	2007	Similarly, the normal propidium ion uptake induced by BzATP at the wild-type P2X(7) receptor was abolished by the two mutants.	Propidium	22-31	purinergic receptor P2X 7	Homo sapiens	77-92
17543459-8	2007	Leptin also inhibited ethanol-induced apoptosis, which was confirmed by [(3)H] thymidine uptake and cell cycle analysis using propidium iodide (PI) staining.	Propidium	126-142	leptin	Homo sapiens	0-6
17635812-10	2007	Membrane damage of propidium iodide-stained NT2-N cells was confirmed by immunofluorescence microscopy and degeneration of neuronal processes was shown with crystal violet staining.	Propidium	19-35	zinc finger protein 263	Mus musculus	44-47
17386946-6	2007	NAA MME treatment increased NAA in neurons and the increase was non-toxic as determined by the low uptake of propidium iodide, a dye that only enters damaged cells.	Propidium	109-125	membrane metallo-endopeptidase	Rattus norvegicus	4-7
17651040-5	2007	Likewise, Annexin V/propidium iodide staining and TUNEL assays demonstrated that both murine Lym-1 and chimeric Lym-1 induced both early and late apoptosis, respectively, unlike anti-CD20 rituximab.	Propidium	20-36	Fc receptor, IgG, low affinity IIb	Mus musculus	93-98
17651040-5	2007	Likewise, Annexin V/propidium iodide staining and TUNEL assays demonstrated that both murine Lym-1 and chimeric Lym-1 induced both early and late apoptosis, respectively, unlike anti-CD20 rituximab.	Propidium	20-36	Fc receptor, IgG, low affinity IIb	Mus musculus	112-117
17428624-8	2007	MNNG-induced DNA damage (measured by the comet assay) and thymocyte death (measured by propidium iodide uptake) was prevented by the PARP inhibitor PJ-34 and by glutathione (GSH) or N-acetylcysteine (NAC).	Propidium	87-103	poly(ADP-ribose) polymerase 1	Homo sapiens	133-137
17559310-0	2007	Long-term, repeated dose in vitro neurotoxicity of the glutamate receptor antagonist L-AP3, demonstrated in rat hippocampal slice cultures by using continuous propidium iodide incubation.	Propidium	159-175	leucine aminopeptidase 3	Rattus norvegicus	85-90
17689130-9	2007	Finally, we found that NIT-GRP78 cells were also more resistant than NIT-1 cells to cytotoxic T lymphocyte (CTL) specific killing detected by flow cytometry through target cells expressing green fluorescent protein cultured with effector cells and finally stained with propidium iodide.	Propidium	269-285	heat shock protein 5	Mus musculus	27-32
17493033-7	2007	In vitro studies showed up-regulation and/or nuclear translocation of Cdk5, p-Cdk5 and p35 in neurons and endothelial cells subjected to oxygen-glucose deficiency, and strong staining was associated with propidium iodide positive nuclei, an indicator of cellular damage.	Propidium	204-220	cyclin dependent kinase 5	Homo sapiens	70-74
17493033-7	2007	In vitro studies showed up-regulation and/or nuclear translocation of Cdk5, p-Cdk5 and p35 in neurons and endothelial cells subjected to oxygen-glucose deficiency, and strong staining was associated with propidium iodide positive nuclei, an indicator of cellular damage.	Propidium	204-220	cyclin dependent kinase 5	Homo sapiens	78-82
17493033-7	2007	In vitro studies showed up-regulation and/or nuclear translocation of Cdk5, p-Cdk5 and p35 in neurons and endothelial cells subjected to oxygen-glucose deficiency, and strong staining was associated with propidium iodide positive nuclei, an indicator of cellular damage.	Propidium	204-220	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	87-90
16777351-9	2006	Quantification of cell death in hippocampal CA1 region was conducted by using propidium iodide fluorescence staining technique.	Propidium	78-94	carbonic anhydrase 1	Homo sapiens	44-47
17294366-2	2007	The majority of oocytes (&gt; or =75%) which bound Annexin V-coated microbeads were viable, as indicated by their propidium iodine (PI) negativity.	Propidium	114-130	annexin A5	Mus musculus	51-60
17181861-10	2006	Flow cytometry demonstrated that LL-37 in a subset of the cells caused a small but rapidly developing increase in membrane permeability to propidium iodide, followed by a gradual development of FITC-annexin V binding.	Propidium	139-155	cathelicidin antimicrobial peptide	Homo sapiens	33-38
16806139-5	2006	Indirect immunofluence combined propidium iodine (PI) nuclei count-staining technology was applied to probe nonmuscle myosin heavy chain IIA (NMMHC-A) in MYH9-related disease neutrophils and platelets.	Propidium	32-48	myosin heavy chain 9	Homo sapiens	108-140
16806139-5	2006	Indirect immunofluence combined propidium iodine (PI) nuclei count-staining technology was applied to probe nonmuscle myosin heavy chain IIA (NMMHC-A) in MYH9-related disease neutrophils and platelets.	Propidium	32-48	myosin heavy chain 9	Homo sapiens	142-149
16806139-5	2006	Indirect immunofluence combined propidium iodine (PI) nuclei count-staining technology was applied to probe nonmuscle myosin heavy chain IIA (NMMHC-A) in MYH9-related disease neutrophils and platelets.	Propidium	32-48	myosin heavy chain 9	Homo sapiens	154-158
17357436-6	2007	Caki-1 cell cycle alterations following TIMP-1 transfection were assessed by fluorescence activated cell sorting (FACS) analysis of propidium iodide (PI)-stained cells.	Propidium	132-148	TIMP metallopeptidase inhibitor 1	Homo sapiens	40-46
18067051-6	2007	Apoptosis of cultured HK-2 was determined by flow cytometry (light scatter and propidium iodide/annexin V-FITC fluorescence) and by nuclear staining with Hoechst 33258.	Propidium	79-95	hexokinase 2	Homo sapiens	22-26
17005406-4	2006	In addition, the propidium displacement experiments showed that these compounds bind AChE to the peripheral anionic site (PAS) of AChE and, consequently, are potential agents that can prevent the aggregation of beta-amyloid.	Propidium	17-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	85-89
17005406-4	2006	In addition, the propidium displacement experiments showed that these compounds bind AChE to the peripheral anionic site (PAS) of AChE and, consequently, are potential agents that can prevent the aggregation of beta-amyloid.	Propidium	17-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	130-134
16806046-2	2006	Annexin-V/propidium iodine double-staining analysis demonstrated that the combination of tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma caused cell death in osteoblastic cells mediated by apoptosis, not necrosis.	Propidium	10-26	interleukin 1 beta	Mus musculus	119-136
16806046-2	2006	Annexin-V/propidium iodine double-staining analysis demonstrated that the combination of tumour necrosis factor-alpha, interleukin-1beta and interferon-gamma caused cell death in osteoblastic cells mediated by apoptosis, not necrosis.	Propidium	10-26	interferon gamma	Mus musculus	141-157
16978807-4	2006	Incubation of dopamine for 24 h in both parental and vector control SK-N-MC cells resulted in 85% and 72% cell death as assessed by annexin-V/propidium iodide analysis.	Propidium	142-158	hedgehog acyltransferase	Homo sapiens	68-72
16740276-3	2006	While 2.5 microM simvastatin or 40 ng/ml TNFalpha alone had only a small effect on apoptosis in HUVECs, co-incubation with simvastatin and TNFalpha markedly increased apoptosis in a time- and dose-dependent manner as measured by FACS analysis of propidium iodide-stained cells.	Propidium	246-262	tumor necrosis factor	Homo sapiens	139-147
16782780-5	2006	The effect of UCP-2 upregulation on the cytotoxic response to cyanide was quantitated by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (apoptosis) and propidium iodide staining (necrosis).	Propidium	175-191	uncoupling protein 2	Homo sapiens	14-19
16497706-6	2006	Annexin V/propidium iodide staining provided the evidence for the induction of apoptosis which was further confirmed by the observation of cleavage of poly (ADP-ribose) polymerase and degradation of acinus.	Propidium	10-26	poly(ADP-ribose) polymerase 1	Homo sapiens	151-179
16135398-7	2006	Exogenous addition of antioxidants, glutathione (GSH) and N-Acetyl-Cysteine (NAC) inhibited the anti-proliferative ability of TPL in both MCF 7 and T47 D. Annexin-V and propidium iodide double staining of cells treated with TPL for 2h revealed that TPL induced significant apoptosis in both the cell lines in a dose dependant manner but magnitude of apoptosis was significantly higher in MCF 7 than in T 47-D cells.	Propidium	169-185	annexin A5	Homo sapiens	155-164
16513374-6	2006	Histone H1-mediated cellular effects, such as anchorage dependent growth and apoptosis, were assessed by colony formation assay, fluorescence microscopy after acridine orange/propidium iodide staining and DNA fragmentation analysis.	Propidium	175-191	H1.0 linker histone	Homo sapiens	0-10
17026843-4	2006	After 48 h of exposure the mean IC50 values in 4 donors were 36 and 31 microM in iDCs and mDC respectively, as detected by propidium iodide incorporation.	Propidium	123-139	chemokine (C-C motif) ligand 22	Mus musculus	90-93
16292251-5	2006	Astrocytes overexpressing Hsp70-WT, -K71E, or -381-640 were all significantly protected from 4 h combined oxygen-glucose deprivation and 24 h reperfusion when assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay or propidium iodide staining and cell counting (P &lt; 0.05).	Propidium	241-257	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	26-31
16806009-2	2006	METHODS: Proliferation and apoptosis of A375 cell with bcl-2 ASODN treatment were evaluated by MTT colorimetric assay, laser scanning confocal microscope (LSCM), TUNEL and Annexin V/propidium iodide(PI), and the level of bcl-2 mRNA expression in A375 cell was detected by RT-PCR before and after being treated by bcl-2 ASODN.	Propidium	182-198	BCL2 apoptosis regulator	Homo sapiens	55-60
16777101-4	2006	Flow cytometry analysis of propidium iodide/annexin-V-stained cells indicated that silencing the G6PT gene induced necrosis and late apoptosis.	Propidium	27-43	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	97-101
16756346-9	2006	Annexin V-fluorescein isothiocyanate (FITC)-propidium iodide (PI) apoptosis flow cytometric assay showed that gallic acid increased the number of early apoptotic (annexin V-FITC+/PI-) and late apoptotic cells (annexin V-FITC+/PI+) but not necrotic cells (annexin V-FITC-/PI+).	Propidium	44-60	annexin A5	Homo sapiens	0-9
16638023-3	2006	Thrombin induced a progressive decline in the number of dopaminergic neurons, an increase in nitric oxide (NO) production, and whole tissue injury indicated by lactate dehydrogenase release and propidium iodide uptake.	Propidium	194-210	coagulation factor II	Rattus norvegicus	0-8
16651717-4	2006	Based on flow cytometric analysis, using annexin V-fluorescein isothiocyanate and propidium iodide as probes to assess apoptosis, LPC induced the apoptosis of HUVECs, and P-21 significantly inhibited this activity by 82.4%.	Propidium	82-98	H3 histone pseudogene 16	Homo sapiens	171-175
16564042-4	2006	Our data demonstrated that group IB PLA (IB PLA2)-exposed murine macrophage 264.7 cells showed characteristic features of apoptosis such as morphological changes, DNA laddering, staining positive for propidium iodide (PI) as well as Annexin V and activation of caspases and subsequent cleavage of poly (ADP-ribose) polymerase (PARP) in dose- and time-dependent manner.	Propidium	200-216	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	36-39
16564042-4	2006	Our data demonstrated that group IB PLA (IB PLA2)-exposed murine macrophage 264.7 cells showed characteristic features of apoptosis such as morphological changes, DNA laddering, staining positive for propidium iodide (PI) as well as Annexin V and activation of caspases and subsequent cleavage of poly (ADP-ribose) polymerase (PARP) in dose- and time-dependent manner.	Propidium	200-216	phospholipase A2, group IIA (platelets, synovial fluid)	Mus musculus	44-48
16319083-9	2006	Interestingly, increased binding of galectin-1 at 4 degrees C correlated with increased propidium iodide (PI) uptake, whereas galectin-3 or -8 binding did not induce permeability to PI.	Propidium	88-104	galectin-1	Cricetulus griseus	36-46
15902298-6	2005	Annexin V/propidium iodide staining showed that the activity of imatinib plus 17-AAG is mediated by apoptosis.	Propidium	10-26	N-methylpurine DNA glycosylase	Homo sapiens	81-84
16197994-4	2006	It was found that TRE, TS1 and TS2 significantly decreased cell count and that TRE caused apoptosis, as confirmed morphologically by confocal microscopy and by flow-cytometric analysis using Annexin-V FITC and propidium iodide (PI).	Propidium	210-226	Trichinella spiralis resistance 2	Mus musculus	31-34
16493071-7	2006	FACS analysis of cells isolated from the CNS showed significantly fewer annexin V/propidium iodide-positive lymphocytes in the CNS of P2X7R-/- mice early in the disease, and TUNEL staining of inflamed CNS tissues supported this result.	Propidium	82-98	acyl-CoA synthetase long-chain family member 1	Mus musculus	0-4
16493071-7	2006	FACS analysis of cells isolated from the CNS showed significantly fewer annexin V/propidium iodide-positive lymphocytes in the CNS of P2X7R-/- mice early in the disease, and TUNEL staining of inflamed CNS tissues supported this result.	Propidium	82-98	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	134-139
16424214-6	2006	Synthesis of active TGFbeta1, induction of IL-10 message, and inhibition of NO synthesis correlate with the amount of surface PS displayed by viable (propidium iodide-negative) infective amastigote.	Propidium	150-166	transforming growth factor, beta 1	Mus musculus	20-28
16230018-3	2005	One of the synthesised compounds emerged as a potent and selective AChE inhibitor, which is able to displace propidium in a competition assay.	Propidium	109-118	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
16279781-3	2005	More importantly, these dual AChE inhibitors inhibit the AChE-induced A beta peptide aggregation with IC50 values 1 order of magnitude lower than that of propidium, thus being the most potent derivatives with this activity reported up to date.	Propidium	154-163	acetylcholinesterase (Cartwright blood group)	Homo sapiens	29-33
16279781-3	2005	More importantly, these dual AChE inhibitors inhibit the AChE-induced A beta peptide aggregation with IC50 values 1 order of magnitude lower than that of propidium, thus being the most potent derivatives with this activity reported up to date.	Propidium	154-163	acetylcholinesterase (Cartwright blood group)	Homo sapiens	57-61
15994859-10	2005	Clusterin bound to single annexin V-positive or annexin V and propidium iodide-positive H9c2 cells.	Propidium	62-78	clusterin	Rattus norvegicus	0-9
15928025-8	2005	There was a significant increase in the number of annexin V-positive (apoptotic) cells and propidium iodide-positive (dead) cells in mouse islets infected with Ad-PANDER compared with control cells infected with Ad-LacZ.	Propidium	91-107	FAM3 metabolism regulating signaling molecule B	Mus musculus	163-169
16092948-10	2005	However, the proportion of Annexin V positive cells also being propidium iodide positive was increased after caspase inhibition.	Propidium	63-79	annexin A5	Rattus norvegicus	27-36
16397141-12	2006	Moreover, treatment with recombinant GDF-15 protected cultured cardiomyocytes from apoptosis during simulated I/R as shown by histone ELISA, TUNEL/Hoechst staining, and annexin V/propidium iodide fluorescence-activated cell sorting (FACS) analysis.	Propidium	179-195	growth differentiation factor 15	Homo sapiens	37-43
16377704-2	2006	Hst 5-induced membrane permeability to propidium iodide (PI) was nearly abolished in strain CaTK1 (TRK1/trk1), suggesting that Hst 5-induced influx of PI is via Trk1p.	Propidium	39-55	tRNA-Lys (anticodon TTT) 3-5	Homo sapiens	99-103
16377704-2	2006	Hst 5-induced membrane permeability to propidium iodide (PI) was nearly abolished in strain CaTK1 (TRK1/trk1), suggesting that Hst 5-induced influx of PI is via Trk1p.	Propidium	39-55	tRNA-Lys (anticodon TTT) 3-5	Homo sapiens	104-108
16377704-2	2006	Hst 5-induced membrane permeability to propidium iodide (PI) was nearly abolished in strain CaTK1 (TRK1/trk1), suggesting that Hst 5-induced influx of PI is via Trk1p.	Propidium	39-55	tRNA-Lys (anticodon TTT) 3-5	Homo sapiens	161-166
17406257-4	2006	The annexin A5 affinity assay comprises the incubation of cells stimulated to execute cell death with fluorescence-labeled annexin A5 and propidium iodide.	Propidium	138-154	annexin A5	Homo sapiens	4-14
16445569-10	2005	Furthermore, the results demonstrated that combined treatment with As2O3 and the MEK1/2 inhibitor U0126 could augment breast cancer MCF-7 cell apoptosis approximately twofold compared with the effects of the two drugs alone, as determined by Hoechst 33258 or annexin V/propidium iodide (PI) staining and flow cytometry.	Propidium	269-285	mitogen-activated protein kinase kinase 1	Homo sapiens	81-87
16338743-6	2005	Treatments of both neuronal types with Vpr, its C-terminal domain, Vpr(52-96), or a shorter fragment, Vpr(70-96), led to dose- and time-dependent cell death as determined by flow cytometry after propidium iodide labeling, phase-contrast microscopy, and TUNEL labeling.	Propidium	195-211	Vpr	Human immunodeficiency virus 1	39-42
16274232-6	2005	These compounds are among the most potent inhibitors of amyloid beta-peptide aggregation and are equivalent only to propidium, a well-characterized AChE peripheral anionic site binder and aggregation inhibitor.	Propidium	116-125	acetylcholinesterase (Cartwright blood group)	Homo sapiens	148-152
15894295-2	2005	Cell cycle analysis by propidium iodide staining in human THP-1 monocytic leukemia cells showed the ability of LCY-2-CHO to increase cell population in sub-G1 stage with time- and concentration-dependent manners.	Propidium	23-39	GLI family zinc finger 2	Homo sapiens	58-63
15465021-4	2004	17Beta-estradiol prevented the apoptosis induced by TNF-alpha in bovine aortic endothelial cells, as evaluated by double staining with fluorescein isothiocyanate-conjugated annexin V and propidium iodide.	Propidium	187-203	tumor necrosis factor	Bos taurus	52-61
15944319-4	2005	In these mice, transgenic IFN-gamma caused epithelial cell DNA injury and apoptosis detectable with TUNEL (Roche) and dual annexin V and propidium iodide staining.	Propidium	137-153	interferon gamma	Mus musculus	26-35
15904931-3	2005	Flow cytometry analyses and confocal microscopy showed that beta2GPI-bh, contrary to native beta(GPI, bound to apoptotic cells, either permeable or non-permeable to propidium iodide (PI), as did annexin-V-FITC.	Propidium	165-181	apolipoprotein H	Homo sapiens	60-68
15695101-8	2005	TREK1 predominantly stained cells around the villous perimeter and this staining was colocalized with propidium iodide nuclear staining.	Propidium	102-118	potassium two pore domain channel subfamily K member 2	Homo sapiens	0-5
15633997-0	2005	Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.	Propidium	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-78
15633997-0	2005	Propidium-based polyamine ligands as potent inhibitors of acetylcholinesterase and acetylcholinesterase-induced amyloid-beta aggregation.	Propidium	0-9	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-103
16182452-8	2005	In conclusion, these data demonstrated that glucocorticoid exposure modulated oxygen-glucose deprivation-mediated propidium iodide uptake, which likely involved glucocorticoid receptor activation and pro-oxidant effects.	Propidium	114-130	nuclear receptor subfamily 3 group C member 1	Homo sapiens	161-184
15623600-7	2004	Gefitinib reduced the cell number ratio more for MMP-7 transfectant than mock cells, and the proportion of apoptotic cells was 1.5 times higher in MMP-7 transfectant than mock cells by annexin/propidium iodide staining.	Propidium	193-209	matrix metallopeptidase 7	Homo sapiens	147-152
15536639-3	2004	METHODS: The annexin V/propidium iodide assay has been adapted for cell surface glycosylation analysis by combining the use of these two reagents with biotinylated lectins, and this has been used to investigate camptothecin-induced apoptosis in U-937 cells.	Propidium	23-39	annexin A5	Homo sapiens	13-22
15755668-6	2005	Lastly, exogenous S-100beta applied to injured cultures decreased PrI uptake, implying a protective role.	Propidium	66-69	S100 calcium binding protein B	Homo sapiens	18-27
15731600-3	2005	METHODS: Death of CA1, CA3, and dentate neurons in rat hippocampal slice cultures was assessed by propidium iodide fluorescence 48-72 h after 60-75 min of hypoxia.	Propidium	98-114	carbonic anhydrase 1	Rattus norvegicus	18-21
15703830-6	2005	Annexin V/propidium iodide staining indicates that the suppression of CD14+ monocyte survival induced by IL-4 and IL-10 results from apoptosis.	Propidium	10-26	CD14 molecule	Homo sapiens	70-74
15703830-6	2005	Annexin V/propidium iodide staining indicates that the suppression of CD14+ monocyte survival induced by IL-4 and IL-10 results from apoptosis.	Propidium	10-26	interleukin 4	Homo sapiens	105-109
15703830-6	2005	Annexin V/propidium iodide staining indicates that the suppression of CD14+ monocyte survival induced by IL-4 and IL-10 results from apoptosis.	Propidium	10-26	interleukin 10	Homo sapiens	114-119
15733770-8	2005	CA1 regional cell death was quantified by propidium iodide (PI) fluorescence.	Propidium	42-58	carbonic anhydrase 1	Rattus norvegicus	0-3
15674800-4	2005	Competition assays using propidium as reference of selective ligand for the peripheral anionic site on acetylcholinesterase indicates the influence of the designed compounds over the peripheral site.	Propidium	25-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-123
15490139-7	2005	Exogenous expression of THRP by transfecting cells with a THRP expression construct (pSVL-THRP) was associated with a significant increase in cell death as measured by the increased number of propidium iodide staining cells (18.0+/-2.1 cells per field) compared with mock-transfected cells (3.3+/-0.2), P&lt;0.002.	Propidium	192-208	abl-interactor 2	Rattus norvegicus	24-28
15490139-7	2005	Exogenous expression of THRP by transfecting cells with a THRP expression construct (pSVL-THRP) was associated with a significant increase in cell death as measured by the increased number of propidium iodide staining cells (18.0+/-2.1 cells per field) compared with mock-transfected cells (3.3+/-0.2), P&lt;0.002.	Propidium	192-208	abl-interactor 2	Rattus norvegicus	58-62
15490139-7	2005	Exogenous expression of THRP by transfecting cells with a THRP expression construct (pSVL-THRP) was associated with a significant increase in cell death as measured by the increased number of propidium iodide staining cells (18.0+/-2.1 cells per field) compared with mock-transfected cells (3.3+/-0.2), P&lt;0.002.	Propidium	192-208	abl-interactor 2	Rattus norvegicus	58-62
16344151-10	2005	Judged by propidium iodide uptake, a selective CA1 lesion, with only minor affection on CA3, occurred in cultures exposed to oxygen-glucose deprivation for 30 min.	Propidium	10-26	carbonic anhydrase 1	Rattus norvegicus	47-50
15378599-3	2004	Death from PP2 occurred by apoptosis as indicated by the induction of caspase activation and annexin V/propidium iodide staining.	Propidium	103-119	neuropeptide Y receptor Y6	Mus musculus	11-14
15634564-2	2004	METHODS: Propidium iodide staining was used to examine cell cycle parameters (G(0)/G(1), S and G(2)/M) of bone marrow mononuclear cells (BMMNCs) while immunofluorescent double staining and FACS techniques were used to measure Ki67 expression in BM CD34+ cells from normal control, patients with MDS, acute myeloid leukemia preceded by MDS (MDS-AML) and primary AML.	Propidium	9-25	CD34 molecule	Homo sapiens	248-252
15364621-10	2004	Flow cytometry after BrdU/propidium labelling confirmed increased cell cycle progression in T-cad overexpressing cells.	Propidium	26-35	cadherin 13	Homo sapiens	92-97
15165989-4	2004	Within 1 h, membrane permeability to propidium iodide (PI) was increased from 5 to 60% in OPN(-/-) cells but was increased to only 20% in WT cells.	Propidium	37-53	secreted phosphoprotein 1	Mus musculus	90-93
15145932-8	2004	Furthermore, the SP-D(GXY)(8)(n/CRD) fragments co-localize with DNA, and the protein competes the interaction between propidium iodide, a DNA-binding dye, and apoptotic cells.	Propidium	118-134	surfactant associated protein D	Mus musculus	17-21
15268903-3	2004	Apoptosis, but not necrosis, in serum-deprived cells could be detected by FACS using Annexin-V/propidium iodine double staining.	Propidium	95-111	acyl-CoA synthetase long-chain family member 1	Mus musculus	74-78
14685807-7	2004	However, propidium iodide reactivity revealed a simultaneous loss of membrane integrity indicative of necrosis, suggesting that AChE-peptide induces cell death via a continuum of apoptotic and necrotic processes.	Propidium	9-25	acetylcholinesterase	Rattus norvegicus	128-140
14666382-10	2004	The population of dead DCs (early and late apoptosis) treated with VEGF increased more than that without VEGF treatment, using the annexin V and propidium iodide evaluation in DCs matured by LPS.	Propidium	145-161	vascular endothelial growth factor A	Homo sapiens	67-71
15160843-4	2004	C. elegans treated with PMAP-23 showed higher fluorescence intensity by propidium iodide (PI) staining than normal cells.	Propidium	72-88	antibacterial peptide PMAP-23	Sus scrofa	24-31
15028535-3	2004	Contrary, the frequencies of annexin V-positive apoptotic cells and propidium iodide-positive dead cells were decreased by the administration of PRL, but were uninfluenced by GH.	Propidium	68-84	prolactin	Oncorhynchus mykiss	145-148
14987257-6	2004	We have found that inhibition of PARG by gallotannin (GT) (50 microM) provided significant cytoprotection to peroxynitrite- or hydrogen peroxide-treated HaCaT cells, as assessed by lactate dehydrogenase release and propidium iodide uptake (parameters of necrotic cell death) as well as caspase activation (apoptotic parameter).	Propidium	215-231	poly(ADP-ribose) glycohydrolase	Homo sapiens	33-37
14998386-0	2004	Evaluation of cytotoxic function and apoptosis in interleukin (IL)-12/IL-15-treated umbilical cord or adult peripheral blood natural killer cells by a propidium-iodide based flow cytometry.	Propidium	151-167	interleukin 15	Homo sapiens	70-75
14670630-6	2004	Propidium iodide fluorescence was observed in the CA1 area after GOD for 30 min, which could be detected in the whole pyramidal cell layer during reperfusion for 24 h. The immunofluorescence of the neuron specific nuclear protein, NeuN, showed a negative correlation with the PI fluorescence.	Propidium	0-16	carbonic anhydrase 1	Homo sapiens	50-53
14670630-6	2004	Propidium iodide fluorescence was observed in the CA1 area after GOD for 30 min, which could be detected in the whole pyramidal cell layer during reperfusion for 24 h. The immunofluorescence of the neuron specific nuclear protein, NeuN, showed a negative correlation with the PI fluorescence.	Propidium	0-16	RNA binding fox-1 homolog 3	Homo sapiens	231-235
14978243-6	2004	The mutant subunits also suppressed the P2X7-dependent pore formation as assessed by uptake of the propidium dye YO-PRO-1 (Molecular Probes, Eugene, OR) in response to 2",3"-O-(4-benzoyl)-benzoyl-ATP (BzATP) in transfected human embryonic kidney 293 cells.	Propidium	99-108	purinergic receptor P2X 7	Homo sapiens	40-44
14729613-8	2004	In addition, we demonstrated enhanced G(1) cell cycle arrest and S phase inhibition by propidium iodide staining of p120(E4F) in the presence of RASSF1A.	Propidium	87-103	E4F transcription factor 1	Homo sapiens	116-124
15237193-4	2004	Activation of caspase-3 and fractin was measured by counting immunohistochemically stained cells and by flow cytometry with propidium iodide (detection of the apoptosis indicating a sub-G1 peak).	Propidium	124-140	caspase 3	Homo sapiens	14-23