PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18087801-2	2007	One synthetic derivative of butein, 2",4",6"-tris(methoxymethoxy)chalcone (TMMC), has potent anti-inflammatory activity via an HO-1 (heme oxygenase 1) dependent pathway.	2',4',6'-tris(methoxymethoxy) chalcone	75-79	heme oxygenase 1	Homo sapiens	127-131
21778460-6	2011	The pretreatment of mice with TMMC reduced the severity of AP and pancreatitis-associated lung injury and inhibited several biochemical parameters (activity of amylase, lipase, trypsin, trypsinogen, and myeloperoxidase and production of proinflammatory cytokines).	2',4',6'-tris(methoxymethoxy) chalcone	30-34	lipase, endothelial	Mus musculus	169-175
21778460-6	2011	The pretreatment of mice with TMMC reduced the severity of AP and pancreatitis-associated lung injury and inhibited several biochemical parameters (activity of amylase, lipase, trypsin, trypsinogen, and myeloperoxidase and production of proinflammatory cytokines).	2',4',6'-tris(methoxymethoxy) chalcone	30-34	myeloperoxidase	Mus musculus	203-218
21778460-7	2011	In addition, TMMC inhibited pancreatic acinar cell death and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 by inhibiting NF-kappaB and extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation.	2',4',6'-tris(methoxymethoxy) chalcone	13-17	tumor necrosis factor	Mus musculus	75-108
21778460-7	2011	In addition, TMMC inhibited pancreatic acinar cell death and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 by inhibiting NF-kappaB and extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation.	2',4',6'-tris(methoxymethoxy) chalcone	13-17	interleukin 1 beta	Mus musculus	110-132
21778460-7	2011	In addition, TMMC inhibited pancreatic acinar cell death and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 by inhibiting NF-kappaB and extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation.	2',4',6'-tris(methoxymethoxy) chalcone	13-17	interleukin 6	Mus musculus	138-142
21778460-7	2011	In addition, TMMC inhibited pancreatic acinar cell death and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 by inhibiting NF-kappaB and extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation.	2',4',6'-tris(methoxymethoxy) chalcone	13-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
21778460-7	2011	In addition, TMMC inhibited pancreatic acinar cell death and production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, and IL-6 by inhibiting NF-kappaB and extracellular signal-regulated protein kinase 1/2 (ERK1/2) activation.	2',4',6'-tris(methoxymethoxy) chalcone	13-17	mitogen-activated protein kinase 3	Mus musculus	222-228
21349266-0	2011	2",4",6"-Tris(methoxymethoxy) chalcone induces apoptosis by enhancing Fas-ligand in activated hepatic stellate cells.	2',4',6'-tris(methoxymethoxy) chalcone	0-38	Fas ligand	Rattus norvegicus	70-80
21349266-5	2011	Interestingly, TMMC treatment remarkably increased Fas-ligand (FasL) mRNA expression in a dose-dependent manner.	2',4',6'-tris(methoxymethoxy) chalcone	15-19	Fas ligand	Rattus norvegicus	51-61
21349266-5	2011	Interestingly, TMMC treatment remarkably increased Fas-ligand (FasL) mRNA expression in a dose-dependent manner.	2',4',6'-tris(methoxymethoxy) chalcone	15-19	Fas ligand	Rattus norvegicus	63-67
21349266-7	2011	In addition, FasL synthesis by TMMC is closely associated with maximal procaspase-3 proteolytic processing.	2',4',6'-tris(methoxymethoxy) chalcone	31-35	Fas ligand	Rattus norvegicus	13-17
21349266-9	2011	TMMC treatment also resulted in apoptosis, as demonstrated by cleavage of poly(ADP-ribose) polymerase in rat liver.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	poly (ADP-ribose) polymerase 1	Rattus norvegicus	74-101
18087801-2	2007	One synthetic derivative of butein, 2",4",6"-tris(methoxymethoxy)chalcone (TMMC), has potent anti-inflammatory activity via an HO-1 (heme oxygenase 1) dependent pathway.	2',4',6'-tris(methoxymethoxy) chalcone	75-79	heme oxygenase 1	Homo sapiens	133-149
17678632-0	2007	2",4",6"-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways.	2',4',6'-tris(methoxymethoxy) chalcone	0-38	tumor necrosis factor	Homo sapiens	113-140
17678632-0	2007	2",4",6"-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways.	2',4',6'-tris(methoxymethoxy) chalcone	0-38	heme oxygenase 1	Homo sapiens	188-204
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	2',4',6'-tris(methoxymethoxy) chalcone	10-14	intercellular adhesion molecule 1	Mus musculus	44-77
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	2',4',6'-tris(methoxymethoxy) chalcone	10-14	interleukin 1 beta	Mus musculus	79-96
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	2',4',6'-tris(methoxymethoxy) chalcone	10-14	interleukin 1 beta	Mus musculus	98-106
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	2',4',6'-tris(methoxymethoxy) chalcone	10-14	tumor necrosis factor	Mus musculus	112-139
17678632-4	2007	Moreover, TMMC suppressed the expression of intercellular adhesion molecule-1, interleukin 1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) in the mice treated with TNBS.	2',4',6'-tris(methoxymethoxy) chalcone	10-14	tumor necrosis factor	Mus musculus	141-150
17678632-5	2007	Pretreatment of human intestinal epithelial HT-29 cells with TMMC also significantly inhibited the IL-8 and extracellular matrix metalloproteinase-7 levels induced by TNF-alpha.	2',4',6'-tris(methoxymethoxy) chalcone	61-65	C-X-C motif chemokine ligand 8	Homo sapiens	99-148
17678632-5	2007	Pretreatment of human intestinal epithelial HT-29 cells with TMMC also significantly inhibited the IL-8 and extracellular matrix metalloproteinase-7 levels induced by TNF-alpha.	2',4',6'-tris(methoxymethoxy) chalcone	61-65	tumor necrosis factor	Homo sapiens	167-176
17678632-6	2007	TMMC induced the expression of heme oxygenase 1 (HO-1) in HT-29 cells.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	heme oxygenase 1	Homo sapiens	31-47
17678632-6	2007	TMMC induced the expression of heme oxygenase 1 (HO-1) in HT-29 cells.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	heme oxygenase 1	Homo sapiens	49-53
17678632-7	2007	TMMC increased extracellular signal-regulated kinase1/2 and p38 kinase phosphorylation levels, which led to the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	mitogen-activated protein kinase 3	Homo sapiens	15-55
17678632-7	2007	TMMC increased extracellular signal-regulated kinase1/2 and p38 kinase phosphorylation levels, which led to the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	mitogen-activated protein kinase 14	Homo sapiens	60-63
17678632-7	2007	TMMC increased extracellular signal-regulated kinase1/2 and p38 kinase phosphorylation levels, which led to the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	137-180
17678632-7	2007	TMMC increased extracellular signal-regulated kinase1/2 and p38 kinase phosphorylation levels, which led to the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	182-186
17678632-7	2007	TMMC increased extracellular signal-regulated kinase1/2 and p38 kinase phosphorylation levels, which led to the nuclear translocation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	heme oxygenase 1	Homo sapiens	208-212
17678632-8	2007	TMMC inhibited TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation directly and indirectly.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	tumor necrosis factor	Homo sapiens	15-24
17678632-8	2007	TMMC inhibited TNF-alpha-induced nuclear factor kappaB (NF-kappaB) activation directly and indirectly.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	nuclear factor kappa B subunit 1	Homo sapiens	56-65
16480975-1	2006	We report that the synthetic chalcone 2",4",6"-tris(methoxymethoxy) chalcone (TMMC) is an anti-inflammatory compound that reduces nitric oxide (NO) production by inhibiting of inducible NO synthase (iNOS) expression, and that TMMC decreases the degradation of the inhibitory factor kappaB, leading to inhibition of nuclear factor-kappaB translocation into the nucleus in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.	2',4',6'-tris(methoxymethoxy) chalcone	226-230	nitric oxide synthase 2	Homo sapiens	176-197
16982036-3	2006	Our aim in this study was to determine whether a new synthetic chalcone derivative, 2",4",6"-tris(methoxymethoxy) chalcone (TMMC) inhibits HSC proliferation induced by serum- or platelet-derived growth factor (PDGF).	2',4',6'-tris(methoxymethoxy) chalcone	84-122	myotrophin	Rattus norvegicus	195-208
16982036-3	2006	Our aim in this study was to determine whether a new synthetic chalcone derivative, 2",4",6"-tris(methoxymethoxy) chalcone (TMMC) inhibits HSC proliferation induced by serum- or platelet-derived growth factor (PDGF).	2',4',6'-tris(methoxymethoxy) chalcone	124-128	myotrophin	Rattus norvegicus	195-208
16982036-4	2006	TMMC significantly inhibited growth factor-induced HSC proliferation.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	myotrophin	Rattus norvegicus	29-42
16982036-5	2006	The inhibition of PDGF-induced proliferation by TMMC was associated with the phosphatidylinositol 3-kinase-Akt-p70(S6K) pathways.	2',4',6'-tris(methoxymethoxy) chalcone	48-52	ribosomal protein S6 kinase B1	Rattus norvegicus	107-118
16982036-6	2006	TMMC induced the expression of heme oxygenase 1 (HO-1) in HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	heme oxygenase 1	Rattus norvegicus	31-47
16982036-6	2006	TMMC induced the expression of heme oxygenase 1 (HO-1) in HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	0-4	heme oxygenase 1	Rattus norvegicus	49-53
16982036-7	2006	Using the chemical inhibitor tin protoporphyrin, we also found that the inhibitory action of TMMC on PDGF-induced proliferation is mediated by HO-1.	2',4',6'-tris(methoxymethoxy) chalcone	93-97	heme oxygenase 1	Rattus norvegicus	143-147
16982036-8	2006	Glutathione (GSH) depletion produced by TMMC activated extracellular signal-regulated kinase (ERK), which led to c-Fos expression and transactivation of activator protein 1 (AP-1) and HO-1 gene expression in the HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	40-44	Eph receptor B1	Rattus norvegicus	55-92
16982036-8	2006	Glutathione (GSH) depletion produced by TMMC activated extracellular signal-regulated kinase (ERK), which led to c-Fos expression and transactivation of activator protein 1 (AP-1) and HO-1 gene expression in the HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	40-44	Eph receptor B1	Rattus norvegicus	94-97
16982036-8	2006	Glutathione (GSH) depletion produced by TMMC activated extracellular signal-regulated kinase (ERK), which led to c-Fos expression and transactivation of activator protein 1 (AP-1) and HO-1 gene expression in the HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	40-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	113-118
16982036-8	2006	Glutathione (GSH) depletion produced by TMMC activated extracellular signal-regulated kinase (ERK), which led to c-Fos expression and transactivation of activator protein 1 (AP-1) and HO-1 gene expression in the HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	40-44	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	153-172
16982036-8	2006	Glutathione (GSH) depletion produced by TMMC activated extracellular signal-regulated kinase (ERK), which led to c-Fos expression and transactivation of activator protein 1 (AP-1) and HO-1 gene expression in the HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	40-44	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	174-178
16982036-8	2006	Glutathione (GSH) depletion produced by TMMC activated extracellular signal-regulated kinase (ERK), which led to c-Fos expression and transactivation of activator protein 1 (AP-1) and HO-1 gene expression in the HSCs.	2',4',6'-tris(methoxymethoxy) chalcone	40-44	heme oxygenase 1	Rattus norvegicus	184-188
16982036-9	2006	These results demonstrate that TMMC preferentially activates ERK and that this activation leads to the transcriptional activation of AP-1 and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	31-35	Eph receptor B1	Rattus norvegicus	61-64
16982036-9	2006	These results demonstrate that TMMC preferentially activates ERK and that this activation leads to the transcriptional activation of AP-1 and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	31-35	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	133-137
16982036-9	2006	These results demonstrate that TMMC preferentially activates ERK and that this activation leads to the transcriptional activation of AP-1 and consequently to HO-1 expression.	2',4',6'-tris(methoxymethoxy) chalcone	31-35	heme oxygenase 1	Rattus norvegicus	158-162
16480975-0	2006	Heme oxygenase 1 mediates anti-inflammatory effects of 2",4",6"-tris(methoxymethoxy) chalcone.	2',4',6'-tris(methoxymethoxy) chalcone	55-93	heme oxygenase 1	Homo sapiens	0-16
16480975-1	2006	We report that the synthetic chalcone 2",4",6"-tris(methoxymethoxy) chalcone (TMMC) is an anti-inflammatory compound that reduces nitric oxide (NO) production by inhibiting of inducible NO synthase (iNOS) expression, and that TMMC decreases the degradation of the inhibitory factor kappaB, leading to inhibition of nuclear factor-kappaB translocation into the nucleus in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.	2',4',6'-tris(methoxymethoxy) chalcone	78-82	nitric oxide synthase 2	Homo sapiens	176-197
16480975-1	2006	We report that the synthetic chalcone 2",4",6"-tris(methoxymethoxy) chalcone (TMMC) is an anti-inflammatory compound that reduces nitric oxide (NO) production by inhibiting of inducible NO synthase (iNOS) expression, and that TMMC decreases the degradation of the inhibitory factor kappaB, leading to inhibition of nuclear factor-kappaB translocation into the nucleus in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages.	2',4',6'-tris(methoxymethoxy) chalcone	78-82	nitric oxide synthase 2	Homo sapiens	199-203
16480975-2	2006	We also demonstrate that TMMC by itself is a potent inducer of heme oxygenase 1 (HO-1).	2',4',6'-tris(methoxymethoxy) chalcone	25-29	heme oxygenase 1	Homo sapiens	63-79
16480975-2	2006	We also demonstrate that TMMC by itself is a potent inducer of heme oxygenase 1 (HO-1).	2',4',6'-tris(methoxymethoxy) chalcone	25-29	heme oxygenase 1	Homo sapiens	81-85
16480975-4	2006	Treating cells with the specific p42/44 MAPK inhibitor, PD98059, blocked the TMMC-mediated induction of HO-1 and the inhibition of LPS-stimulated expression of iNOS.	2',4',6'-tris(methoxymethoxy) chalcone	77-81	cyclin dependent kinase 20	Homo sapiens	33-36
16480975-4	2006	Treating cells with the specific p42/44 MAPK inhibitor, PD98059, blocked the TMMC-mediated induction of HO-1 and the inhibition of LPS-stimulated expression of iNOS.	2',4',6'-tris(methoxymethoxy) chalcone	77-81	heme oxygenase 1	Homo sapiens	104-108
16480975-6	2006	Our data suggest that TMMC exerts an anti-inflammatory effect in macrophages through a mechanism that involves the induction of HO-1, which is mediated by activation of p42/44 MAPK and GSH depletion.	2',4',6'-tris(methoxymethoxy) chalcone	22-26	heme oxygenase 1	Homo sapiens	128-132
16480975-6	2006	Our data suggest that TMMC exerts an anti-inflammatory effect in macrophages through a mechanism that involves the induction of HO-1, which is mediated by activation of p42/44 MAPK and GSH depletion.	2',4',6'-tris(methoxymethoxy) chalcone	22-26	cyclin dependent kinase 20	Homo sapiens	169-172