PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8612823-2 1996 TMHs 6 and 7 and the e3 loop of the mu opioid receptor were important for selective binding of sufentanil and lofentanil to the mu over the kappa receptor. lofentanil 110-120 LHFPL tetraspan subfamily member 5 Homo sapiens 0-4 18996171-9 2009 When the specific serotonin antagonist N-[2[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-cyclohexanecarboxamide maleate (WAY 100635, 100 microg/kg) was injected 15 min before 8-OH-DPAT, this specific antagonist reverses the effects caused by the 5-HT(1A) agonist. Serotonin 18-27 5-hydroxytryptamine receptor 1A Rattus norvegicus 256-263 18925655-1 2009 The effect of a pharmacologic increase in serotonin concentrations on striatal dopamine (D2) receptor availability has been measured in several studies using positron emission tomography (PET) and the radiotracer [11C]-raclopride as a method for the in vivo imaging of serotonin modulation of striatal dopamine in human subjects. Serotonin 42-51 dopamine receptor D2 Homo sapiens 79-101 20048018-2 2010 A member of the ETS oncogene family of transcription factors, Fev, acts with the homeodomain transcription factor Nkx2.2 in the development of serotonin neurons in mice. Serotonin 143-152 NK2 homeobox 2 Mus musculus 114-120 25277944-1 2014 AIMS: The aim of this study was to elucidate myocardial interstitial serotonin (5-HT) kinetics in the heart, including 5-HT reuptake and enzymatic degradation to 5-hydroxyindole acetic acid (5-HIAA) via monoamine oxidase (MAO). Serotonin 69-78 monoamine oxidase A Rattus norvegicus 222-225 24997405-5 2014 Low concentrations of serotonin (up to 5 muM) enhanced FRT cell growth, and ERK1/2 and SMAD2/3 phosphorylation. Serotonin 22-31 mitogen activated protein kinase 3 Rattus norvegicus 76-82 19755127-0 2010 SDF-1alpha/CXCL12 enhances GABA and glutamate synaptic activity at serotonin neurons in the rat dorsal raphe nucleus. Serotonin 67-76 C-X-C motif chemokine ligand 12 Rattus norvegicus 11-17 24997405-8 2014 On the other hand, high doses of serotonin (50 muM up to 1 mM) activated a caspase-3 mediated apoptosis of cells. Serotonin 33-42 caspase 3 Rattus norvegicus 75-84 19931593-2 2010 Regulator of G-protein signaling 2 (RGS2) proteins regulate intracellular signaling and second messenger activation of molecules including dopamine, serotonin, and acetylcholine receptors, all of which appear to be involved in the pathophysiology of AIEPSs. Serotonin 149-158 regulator of G protein signaling 2 Homo sapiens 36-40 18952677-2 2008 We have recently demonstrated that dopamine released from serotonin neurons is responsible for l-DOPA-induced dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, raising the possibility that blockade of serotonin neuron activity by combination of 5-HT(1A) and 5-HT(1B) agonists could reduce l-DOPA-induced dyskinesia. Serotonin 58-67 5-hydroxytryptamine receptor 1A Rattus norvegicus 251-258 18952677-2 2008 We have recently demonstrated that dopamine released from serotonin neurons is responsible for l-DOPA-induced dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, raising the possibility that blockade of serotonin neuron activity by combination of 5-HT(1A) and 5-HT(1B) agonists could reduce l-DOPA-induced dyskinesia. Serotonin 207-216 5-hydroxytryptamine receptor 1A Rattus norvegicus 251-258 25051442-4 2014 Using a selective ARC-deficient POMC mouse line, here we report that former obesity medications augmenting endogenous 5-hydroxytryptamine (5-HT) activity d-fenfluramine and sibutramine require ARC POMC neurons to elicit therapeutic appetite-suppressive effects. Serotonin 118-137 pro-opiomelanocortin-alpha Mus musculus 32-36 25051442-4 2014 Using a selective ARC-deficient POMC mouse line, here we report that former obesity medications augmenting endogenous 5-hydroxytryptamine (5-HT) activity d-fenfluramine and sibutramine require ARC POMC neurons to elicit therapeutic appetite-suppressive effects. Serotonin 118-137 pro-opiomelanocortin-alpha Mus musculus 197-201 19198157-2 2008 It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide. Serotonin 136-145 monoamine oxidase A Rattus norvegicus 29-32 21452478-10 2010 The inhibition of fat intake occurs through reduced gastric emptying and serotonin release (Ritter, 2004). Serotonin 73-82 FAT atypical cadherin 1 Homo sapiens 18-21 19198157-2 2008 It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide. Serotonin 136-145 monoamine oxidase A Rattus norvegicus 47-50 24972070-6 2014 Deletion of NaV1.9 substantially attenuates excitation and subsequent mechanical hypersensitivity after application of inflammatory soup (IS) (bradykinin, ATP, histamine, PGE2, and 5HT) to visceral nociceptors located in the serosa and mesentery. Serotonin 181-184 sodium voltage-gated channel alpha subunit 11 Homo sapiens 12-18 19198157-2 2008 It has been established that MAO of mink, like MAO of rat, has properties of classic mammalian MAO: it deaminates tyramine, tryptamine, serotonin, benzilamine, beta-phenylethylamine and does not deaminate histamine as well as does not have sensitivity to semicarbazide. Serotonin 136-145 monoamine oxidase A Rattus norvegicus 47-50 20385066-6 2010 Our report describes additional biological activities for RANTES, MCP-1, and IL-8, suggesting that these chemokines play a fundamental role in histamine and serotonin generation and cell function in mast cells. Serotonin 157-166 chemokine (C-X-C motif) ligand 15 Mus musculus 77-81 24841869-7 2014 (+-)-cis-4,4"-DMAR was a potent, efficacious substrate-type releaser at transporters for dopamine, norepinephrine and serotonin with EC50 values of 8.6 +- 1.1 nM (DAT), 26.9 +- 5.9 nM (NET) and 18.5 +- 2.8 nM (SERT), respectively. Serotonin 118-127 solute carrier family 6 member 3 Rattus norvegicus 163-166 20329492-10 2010 CONCLUSION: An increased expression of TPH1 in canine and human myxomatous mitral valves implicates an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valves. Serotonin 113-122 tryptophan hydroxylase 1 Canis lupus familiaris 39-43 19615378-5 2010 Serotonin also reduced the amplitude of L-type calcium currents and influenced the strength of GJIC without modifying the phosphorylation profiles of the different channel-forming proteins or connexins (Cxs), namely Cx40, Cx43 and Cx45. Serotonin 0-9 gap junction protein, gamma 1 Rattus norvegicus 231-235 19507004-1 2009 Recently, we discovered that transient receptor potential ankyrin1 channel (TRPA1) is highly expressed in human and rat enterochromaffin (EC) cells, and those TRPA1 agonists such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA) enhance the release of serotonin (5-hydroxytryptamine; 5-HT) from EC cells in vitro. Serotonin 258-267 transient receptor potential cation channel subfamily A member 1 Homo sapiens 76-81 19507004-1 2009 Recently, we discovered that transient receptor potential ankyrin1 channel (TRPA1) is highly expressed in human and rat enterochromaffin (EC) cells, and those TRPA1 agonists such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA) enhance the release of serotonin (5-hydroxytryptamine; 5-HT) from EC cells in vitro. Serotonin 269-288 transient receptor potential cation channel subfamily A member 1 Homo sapiens 76-81 18797297-1 2008 In adult rats, serotonin 1A (5-HT1A) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2A) neuroendocrine function at 1 h that persists up to 72 h. This study determined whether prolonged 5-HT1A/5-HT2A cross-talk exists before sexual maturation. Serotonin 15-24 5-hydroxytryptamine receptor 1A Rattus norvegicus 29-35 18797297-1 2008 In adult rats, serotonin 1A (5-HT1A) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2A) neuroendocrine function at 1 h that persists up to 72 h. This study determined whether prolonged 5-HT1A/5-HT2A cross-talk exists before sexual maturation. Serotonin 15-24 5-hydroxytryptamine receptor 2A Rattus norvegicus 112-118 18797297-1 2008 In adult rats, serotonin 1A (5-HT1A) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2A) neuroendocrine function at 1 h that persists up to 72 h. This study determined whether prolonged 5-HT1A/5-HT2A cross-talk exists before sexual maturation. Serotonin 15-24 5-hydroxytryptamine receptor 1A Rattus norvegicus 217-223 18797297-1 2008 In adult rats, serotonin 1A (5-HT1A) receptor activation produces heterologous desensitization of serotonin 2A (5-HT2A) neuroendocrine function at 1 h that persists up to 72 h. This study determined whether prolonged 5-HT1A/5-HT2A cross-talk exists before sexual maturation. Serotonin 15-24 5-hydroxytryptamine receptor 2A Rattus norvegicus 224-230 18981671-1 2008 Tryptophan hydroxylase (TPH) serves as the rate-limiting enzyme in the biosynthesis of serotonin, and two forms of TPH genes, TPH1 and TPH2, have been reported with specific nucleotide sequences and expression patterns. Serotonin 87-96 tryptophan hydroxylase 1 Canis lupus familiaris 126-130 19837463-5 2009 This announcement closely follows a report that another NR2B antagonist, traxoprodil (CP 101 606), has antidepressant effects in patients unresponsive to a serotonin selective reuptake inhibitor, as well as reports of rapid and sustained antidepressant effects following a single injection of the NMDA antagonist ketamine. Serotonin 156-165 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 56-60 24921650-4 2014 Here we show that in C. elegans loss of aak-2 mimics the effects of elevated serotonin signaling on fat reduction, slowed movement, and promoting exit from dauer arrest. Serotonin 77-86 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans 40-45 24921650-6 2014 As in elevated serotonin signaling, inactivation of AAK-2 in the ASI neurons caused enhanced secretion of dense core vesicles from these neurons. Serotonin 15-24 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans 52-57 24921650-8 2014 These findings show that elevated levels of serotonin promote enhanced secretions of systemic regulators of pro-growth and differentiation pathways through inactivation of AAK-2. Serotonin 44-53 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans 172-177 24921650-10 2014 Our data suggest that some of the physiological phenotypes previously attributed to peripheral AAK-2 activity on metabolic targets may instead be due to the role of this kinase in neural serotonin signaling. Serotonin 187-196 5'-AMP-activated protein kinase catalytic subunit alpha-2 Caenorhabditis elegans 95-100 24913307-1 2014 BACKGROUND: It has been recently recognized that the descending serotonin (5-HT) system from the rostral ventromedial medulla (RVM) in the brainstem and the 5-HT3 receptor subtype in the spinal dorsal horn are involved in enhanced descending pain facilitation after tissue and nerve injury. Serotonin 64-73 5-hydroxytryptamine receptor 3A Rattus norvegicus 157-171 18799680-4 2008 In dorsal root ganglia (DRG) neurons of Nox1(+/Y), pretreatment with chemical mediators bradykinin, serotonin, or phorbol 12-myristate 13-acetate (PMA) augmented the capsaicin-induced calcium increase, whereas this increase was significantly attenuated in DRG neurons of Nox1(-/Y). Serotonin 100-109 NADPH oxidase 1 Mus musculus 40-44 18799680-4 2008 In dorsal root ganglia (DRG) neurons of Nox1(+/Y), pretreatment with chemical mediators bradykinin, serotonin, or phorbol 12-myristate 13-acetate (PMA) augmented the capsaicin-induced calcium increase, whereas this increase was significantly attenuated in DRG neurons of Nox1(-/Y). Serotonin 100-109 NADPH oxidase 1 Mus musculus 271-279 24936175-0 2014 Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression. Serotonin 0-9 coiled-coil and C2 domain containing 1A Mus musculus 117-132 18492725-4 2008 GluR-A(-/-) mice display increased learned helplessness, decreased serotonin and norepinephrine levels, and disturbed glutamate homeostasis with increased glutamate levels and increased NMDA receptor expression. Serotonin 67-76 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 0-6 24517902-6 2014 5-HT- or 5-CT-induced antinociception in the formalin test was diminished by the selective 5-HT5A receptor antagonist N-[2-(dimethylamino)ethyl]-N-[[4"-[[(2-phenylethyl)amino] methyl][1,1"-biphenyl]-4-yl]methyl]cyclopentanepropanamide dihydrochloride (SB-699551; 3 and 10 nmol). Serotonin 0-4 5-hydroxytryptamine receptor 5A Rattus norvegicus 91-97 18840973-2 2008 They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. Serotonin 59-68 solute carrier family 6 member 4 Canis lupus familiaris 115-121 24412488-6 2014 We measured release of serotonin and glucagon-like peptide-1 from human and mice TBC in response to CD36 and GPR120 activation. Serotonin 23-32 free fatty acid receptor 4 Mus musculus 109-115 18515178-1 2008 Guanosine triphosphate cyclohydrolase 1 (GCH1) is the first enzyme in the tetrahydrobiopterin (BH4) biosynthesis, an important co-factor for the formation of nitric oxide, biogenic amines and serotonin. Serotonin 192-201 GTP cyclohydrolase 1 Homo sapiens 0-39 18515178-1 2008 Guanosine triphosphate cyclohydrolase 1 (GCH1) is the first enzyme in the tetrahydrobiopterin (BH4) biosynthesis, an important co-factor for the formation of nitric oxide, biogenic amines and serotonin. Serotonin 192-201 GTP cyclohydrolase 1 Homo sapiens 41-45 24524998-0 2014 Serotonin regulates innate immune responses of colon epithelial cells through Nox2-derived reactive oxygen species. Serotonin 0-9 cytochrome b-245, beta polypeptide Mus musculus 78-82 18321937-7 2008 Serotonin antagonists promoted an antifibrotic environment by decreasing the lung mRNA levels of transforming growth factor-beta1, connective growth factor and plasminogen activator inhibitor-1 mRNA, but had minimal effects on lung inflammation as assessed by bronchoalveolar lavage cytology analysis. Serotonin 0-9 transforming growth factor, beta 1 Mus musculus 97-129 24440442-1 2014 Serotonin signalling in the heart is mediated by receptor subtype 2B (5-HTR2B). Serotonin 0-9 5-hydroxytryptamine receptor 2B Canis lupus familiaris 49-77 18665222-2 2008 In an earlier study, we found that serotonin (5-HT), acting through the 5-HT1A receptor subtype, promotes axonal transport of mitochondria in cultured hippocampal neurons by increasing Akt activity, and consequently decreasing glycogen synthase kinase (GSK3beta) activity. Serotonin 35-44 glycogen synthase kinase 3 beta Homo sapiens 253-261 18400843-1 2008 Transglutaminase (TGase)-induced activation of small G proteins via 5-hydroxytryptamine (HT)(2A) receptor signaling leads to platelet aggregation (Cell 115:851-862, 2003). Serotonin 68-87 transglutaminase 1 Homo sapiens 0-16 23787365-2 2013 In the dorsal periaqueductal gray matter (dPAG), another key panic-associated area, serotonin, through the activation of 5-HT1A and 5-HT2A receptors, exerts an inhibitory role on escape expression. Serotonin 84-93 5-hydroxytryptamine receptor 1A Rattus norvegicus 121-133 18400843-1 2008 Transglutaminase (TGase)-induced activation of small G proteins via 5-hydroxytryptamine (HT)(2A) receptor signaling leads to platelet aggregation (Cell 115:851-862, 2003). Serotonin 68-87 transglutaminase 1 Homo sapiens 18-23 18400843-2 2008 We hypothesize that stimulation of 5-HT(2A) receptors in neurons activates TGase, resulting in transamidation of serotonin to a small G protein, Rac1, thereby constitutively activating Rac1. Serotonin 113-122 transglutaminase 1 Homo sapiens 75-80 18400843-3 2008 Using immunoprecipitation and immunoblotting, we show that, in rat cortical cell line A1A1v, serotonin increases TGase-catalyzed transamidation of Rac1. Serotonin 93-102 transglutaminase 1 Homo sapiens 113-118 18400843-3 2008 Using immunoprecipitation and immunoblotting, we show that, in rat cortical cell line A1A1v, serotonin increases TGase-catalyzed transamidation of Rac1. Serotonin 93-102 Rac family small GTPase 1 Rattus norvegicus 147-151 18400843-10 2008 Serotonin itself is bound to Rac1 by TGase following 5-HT(2A) receptor stimulation as demonstrated by coimmunoprecipitation experiments and a dose-dependent decrease of serotonin-associated Rac1 by cystamine. Serotonin 0-9 transglutaminase 1 Homo sapiens 37-42 24211588-0 2013 Serotonin acts as a novel regulator of interleukin-6 secretion in osteocytes through the activation of the 5-HT(2B) receptor and the ERK1/2 signalling pathway. Serotonin 0-9 mitogen-activated protein kinase 3 Mus musculus 133-139 24211588-8 2013 We found that serotonin significantly activated the ERK1/2 pathway and induced IL-6 mRNA expression and protein synthesis in cultured MLO-Y4 cells. Serotonin 14-23 mitogen-activated protein kinase 3 Mus musculus 52-58 24211588-10 2013 Our results indicate that serotonin stimulates osteocyte secretion of IL-6 and that this effect is associated with activation of 5-HT2B receptor and the ERK1/2 pathway. Serotonin 26-35 mitogen-activated protein kinase 3 Mus musculus 153-159 24095796-3 2013 METHODS AND RESULTS: In embryos lacking the sodium-dependent vitamin C transporter 2 (SVCT2), very low levels of brain ascorbate decreased cortex levels of norepinephrine and dopamine by approximately 33%, but had no effect on cortex serotonin or its metabolite, 5-hydroxyindole acetic acid. Serotonin 234-243 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 86-91 18214896-2 2008 Serotonin (5-HT) and 4-methylumbelliferone (4-MU) were used as the substrates for UGT1A6. Serotonin 0-9 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 82-88 18214896-2 2008 Serotonin (5-HT) and 4-methylumbelliferone (4-MU) were used as the substrates for UGT1A6. Serotonin 11-15 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 82-88 24095796-5 2013 Increased cortex ascorbate in embryos carrying extra copies of the SVCT2 resulted in increased levels of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), as well as serotonin and 5-hydroxyindole acetic acid. Serotonin 185-194 solute carrier family 23 (nucleobase transporters), member 2 Mus musculus 67-72 18313044-0 2008 A dual role of 5-hydroxytryptamine receptor 3 in serotonin induced ion transport in rat distal colon. Serotonin 49-58 5-hydroxytryptamine receptor 3A Rattus norvegicus 15-45 23929722-7 2013 Co-incubation experiments of SH-SY5Y cells with the TRPV1 inhibitors trans-tert-butylcyclohexanol and capsazepine demonstrated that capsaicin, but not nonivamide, induces serotonin and dopamine release through TRPV1 activation. Serotonin 171-180 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 18294854-2 2008 hCA IX was activated efficiently by dopamine, adrenaline and heterocyclic amines possessing aminoethyl-/aminomethyl-moieties (K(A)s of 9 nM-1.07 microM), whereas the best hCA XII activators were serotonin, L-adrenaline, 4-(2-aminoethyl)-morpholine and d-Phe (K(A) of 0.24-0.41 microM). Serotonin 195-204 carbonic anhydrase 9 Homo sapiens 0-6 24016069-8 2013 Lysergic acid diethylamide, phencyclidine, and similar drugs that activate 5HT2A serotonin receptors produce psychotic syndromes, and almost all antipsychotic neuroleptics share the property of blocking the 5HT2A receptor as well as the dopamine D2 receptor. Serotonin 81-90 dopamine receptor D2 Homo sapiens 237-257 18294854-2 2008 hCA IX was activated efficiently by dopamine, adrenaline and heterocyclic amines possessing aminoethyl-/aminomethyl-moieties (K(A)s of 9 nM-1.07 microM), whereas the best hCA XII activators were serotonin, L-adrenaline, 4-(2-aminoethyl)-morpholine and d-Phe (K(A) of 0.24-0.41 microM). Serotonin 195-204 carbonic anhydrase 12 Homo sapiens 171-178 23917247-0 2013 Purinergic autocrine regulation of mechanosensitivity and serotonin release in a human EC model: ATP-gated P2X3 channels in EC are downregulated in ulcerative colitis. Serotonin 58-67 purinergic receptor P2X 3 Homo sapiens 107-111 18234316-6 2008 The amounts of histamine/serotonin stored were reflected by the expression levels of histidine decarboxylase and tryptophan hydroxylase 1, respectively. Serotonin 25-34 histidine decarboxylase Homo sapiens 85-108 18023073-2 2008 The purpose of the present study was to determine whether the tyrosine hydroxylase (TH) val81met and catechol-O-methyltransferase (COMT) val158met polymorphisms are associated with the antidepressant effect of milnacipran, a serotonin/noradrenaline reuptake inhibitor. Serotonin 225-234 catechol-O-methyltransferase Homo sapiens 131-135 23680103-2 2013 NPS has shown strong anxiolytic-like effects and interactions with other central transmitter systems, including serotonin and glutamate. Serotonin 112-121 neuropeptide S Homo sapiens 0-3 18032578-2 2008 Raphe nuclei, which modulate several physiological functions through serotonin, receive dense projections from orexin-containing neurons in the hypothalamus. Serotonin 69-78 hypocretin Mus musculus 111-117 23680103-10 2013 In particular, the early onset OCD subtype seems to be characterized by a genetically driven low NPS tone, which might affect other OCD-related transmitter systems, including the serotonin and glutamate systems. Serotonin 179-188 neuropeptide S Homo sapiens 97-100 23965265-2 2013 This study investigates whether social cognition varies with genetic variations of COMT and tryptophan hydroxylase-2 (TPH2), which modulate dopamine and serotonin neurotransmissions respectively, and thereby emotion regulation. Serotonin 153-162 catechol-O-methyltransferase Homo sapiens 83-87 17868153-7 2008 SPR, the most strongly up-regulated protein observed, controls production of tetrahydrobiopterin, an essential cofactor for the synthesis of many neurotransmitters including serotonin, making it a plausible and intriguing candidate protein for involvement in mood control and antidepressant drug action. Serotonin 174-183 sepiapterin reductase Homo sapiens 0-3 23973145-9 2013 TRPV1 and metalloproteinases contribute and supraspinal descending facilitation of 5-hydroxytryptamine (5-HT)/5-HT 3 receptors may also contribute to OA pain. Serotonin 83-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 18036835-3 2008 Of the biomarkers in the serotonin system, serotonin(1A) (5-HT(1A)) receptor is implicated in depression, and anxiety and serotonin transporter (5-HTT) is a target for selective serotonin reuptake inhibitors, psychotropic drugs used in the treatment of these disorders. Serotonin 25-34 huntingtin Homo sapiens 147-150 18036835-9 2008 Sex differences in 5-HT(1A) receptor and 5-HTT BP(ND) may reflect biological distinctions in the serotonin system contributing to sex differences in the prevalence of psychiatric disorders such as depression and anxiety. Serotonin 97-106 huntingtin Homo sapiens 43-46 23997373-4 2013 The responsiveness of orexin neurons to 5HT in vitro and the sleep/wakefulness patterns were compared between 5HT1A-overexpressing and control mice. Serotonin 40-43 hypocretin Mus musculus 22-28 17670899-7 2008 The effect of UF from individuals with CKD and DM was significantly greater than that from patients with CKD alone, and the responses were partially inhibited by the protein kinase Cdelta (PKCdelta) inhibitor rottlerin and the 5-hydroxytryptamine (5-HT)(2A/2C) receptor antagonist ritanserin. Serotonin 227-246 protein kinase C delta Homo sapiens 166-187 17670899-7 2008 The effect of UF from individuals with CKD and DM was significantly greater than that from patients with CKD alone, and the responses were partially inhibited by the protein kinase Cdelta (PKCdelta) inhibitor rottlerin and the 5-hydroxytryptamine (5-HT)(2A/2C) receptor antagonist ritanserin. Serotonin 227-246 protein kinase C delta Homo sapiens 189-197 23997373-5 2013 MEASUREMENTS AND RESULTS: When the 5HT1A receptor was overexpressed in orexin neurons of Orexin-EGFP; orexin-tTA; TetO Htr1a mice, 5HT-induced inhibition of orexin neurons was prolonged. Serotonin 35-38 hypocretin Mus musculus 71-77 23997373-5 2013 MEASUREMENTS AND RESULTS: When the 5HT1A receptor was overexpressed in orexin neurons of Orexin-EGFP; orexin-tTA; TetO Htr1a mice, 5HT-induced inhibition of orexin neurons was prolonged. Serotonin 35-38 hypocretin Mus musculus 89-95 23997373-5 2013 MEASUREMENTS AND RESULTS: When the 5HT1A receptor was overexpressed in orexin neurons of Orexin-EGFP; orexin-tTA; TetO Htr1a mice, 5HT-induced inhibition of orexin neurons was prolonged. Serotonin 35-38 hypocretin Mus musculus 102-108 23997373-5 2013 MEASUREMENTS AND RESULTS: When the 5HT1A receptor was overexpressed in orexin neurons of Orexin-EGFP; orexin-tTA; TetO Htr1a mice, 5HT-induced inhibition of orexin neurons was prolonged. Serotonin 35-38 hypocretin Mus musculus 102-108 23972393-4 2013 Serotonin promotes dwelling states through the MOD-1 serotonin-gated chloride channel. Serotonin 0-9 Uncharacterized protein Caenorhabditis elegans 47-52 17559083-2 2008 Since central CO(2) chemoreception is subject to neural modulations, we performed studies to test the hypothesis that the Kir4.1-Kir5.1 channel is modulated by the neurotransmitters critical for respiratory control, including serotonin (5-HT), substance-P (SP), and thyrotropin releasing hormone (TRH). Serotonin 226-235 potassium inwardly rectifying channel subfamily J member 10 S homeolog Xenopus laevis 122-128 24392577-1 2013 Tyrosine hydroxylase and tryptophan hydroxylase are key rate limiting enzymes in the biosynthesis of dopamine and serotonin, respectively. Serotonin 114-123 tyrosine hydroxylase Rattus norvegicus 0-20 23475395-0 2013 Histamine, carbachol, and serotonin induce hyperresponsiveness to ATP in guinea pig tracheas: involvement of COX-2 pathway. Serotonin 26-35 cytochrome c oxidase subunit II Cavia porcellus 109-114 17719142-0 2008 CB1-cannabinoid receptors are involved in the modulation of non-synaptic [3H]serotonin release from the rat hippocampus. Serotonin 77-86 cannabinoid receptor 1 (brain) Mus musculus 0-3 17392733-2 2008 Serotonin (5-hydroxytryptamine, 5-HT) inhibits sexual behavior via effects in the MPOA, where there are high densities of 5-HT(1A) and 5-HT(1B) receptor subtypes. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 122-129 23519266-4 2013 Dfen mediates PAH via a serotonergic mechanism and we have shown serotonin to up-regulate expression of CYP1B1 in human pulmonary artery smooth muscle cells (PASMCs). Serotonin 65-74 cytochrome P450 family 1 subfamily B member 1 Homo sapiens 104-110 17392733-2 2008 Serotonin (5-hydroxytryptamine, 5-HT) inhibits sexual behavior via effects in the MPOA, where there are high densities of 5-HT(1A) and 5-HT(1B) receptor subtypes. Serotonin 11-30 5-hydroxytryptamine receptor 1A Rattus norvegicus 122-129 23353901-1 2013 There are seemingly conflicting data in the literature regarding the role of serotonin (5-HT) 5-HT2C receptors in the mouse head-twitch response (HTR) elicited by the hallucinogenic 5-HT2A/2B/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI). Serotonin 77-86 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 94-100 18516508-3 2008 Since the production of brain serotonin is limited by the availability of its plasma dietary amino acid precursor tryptophan, different foods and dietary amino acids that influence tryptophan availability are thought to alter affective behavior by changing brain 5-HT synthesis. Serotonin 30-39 POU class 6 homeobox 1 Homo sapiens 257-264 23266708-1 2013 Understanding the influences of genes involved in dopamine and serotonin metabolism, such as the aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes, is critical for understanding addictive behavior. Serotonin 63-72 aldehyde dehydrogenase 2 family member Homo sapiens 97-121 17905422-0 2008 Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents. Serotonin 81-90 5-hydroxytryptamine receptor 1A Rattus norvegicus 91-103 23266708-1 2013 Understanding the influences of genes involved in dopamine and serotonin metabolism, such as the aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes, is critical for understanding addictive behavior. Serotonin 63-72 aldehyde dehydrogenase 2 family member Homo sapiens 123-128 23395646-7 2013 RESULTS: Microarray analysis revealed that the colonic mucosa of ZBP-89(DeltaInt) mice had reduced levels of tryptophan hydroxylase 1 (Tph1) messenger RNA, encoding the rate-limiting enzyme in enterochromaffin cell serotonin (5-hydroxytryptamine [5HT]) biosynthesis. Serotonin 215-224 zinc finger protein 148 Mus musculus 65-71 23395646-7 2013 RESULTS: Microarray analysis revealed that the colonic mucosa of ZBP-89(DeltaInt) mice had reduced levels of tryptophan hydroxylase 1 (Tph1) messenger RNA, encoding the rate-limiting enzyme in enterochromaffin cell serotonin (5-hydroxytryptamine [5HT]) biosynthesis. Serotonin 226-245 zinc finger protein 148 Mus musculus 65-71 18094252-10 2007 We conclude that (1) RTN receives input from multiple raphe nuclei, (2) serotonin, substance P, and TRH activate RTN chemoreceptors, and (3) excitatory effects of serotonin and pH are mediated by distinct ionic conductances. Serotonin 163-172 thyrotropin releasing hormone Homo sapiens 100-103 23395646-7 2013 RESULTS: Microarray analysis revealed that the colonic mucosa of ZBP-89(DeltaInt) mice had reduced levels of tryptophan hydroxylase 1 (Tph1) messenger RNA, encoding the rate-limiting enzyme in enterochromaffin cell serotonin (5-hydroxytryptamine [5HT]) biosynthesis. Serotonin 247-250 zinc finger protein 148 Mus musculus 65-71 23196068-4 2013 Since l-dopa could be decarboxylated by aromatic amino acid decarboxylase (AADC) present within both dopamine and serotonin neurons, it was hypothesized that serotonin neurons convert l-dopa into dopamine to generate excessive reactive oxygen species and quinoproteins that ultimately lead to serotonin neuron death. Serotonin 114-123 dopa decarboxylase Rattus norvegicus 75-79 18026700-1 2007 OBJECTIVE: In earlier experiments the immune cells of HDC gene knock-out (HDC-KO) mice contained significantly more serotonin, than those of the wild ones. Serotonin 116-125 histidine decarboxylase Mus musculus 54-57 23196068-4 2013 Since l-dopa could be decarboxylated by aromatic amino acid decarboxylase (AADC) present within both dopamine and serotonin neurons, it was hypothesized that serotonin neurons convert l-dopa into dopamine to generate excessive reactive oxygen species and quinoproteins that ultimately lead to serotonin neuron death. Serotonin 158-167 dopa decarboxylase Rattus norvegicus 75-79 18026700-1 2007 OBJECTIVE: In earlier experiments the immune cells of HDC gene knock-out (HDC-KO) mice contained significantly more serotonin, than those of the wild ones. Serotonin 116-125 histidine decarboxylase Mus musculus 74-77 23196068-4 2013 Since l-dopa could be decarboxylated by aromatic amino acid decarboxylase (AADC) present within both dopamine and serotonin neurons, it was hypothesized that serotonin neurons convert l-dopa into dopamine to generate excessive reactive oxygen species and quinoproteins that ultimately lead to serotonin neuron death. Serotonin 158-167 dopa decarboxylase Rattus norvegicus 75-79 23486969-6 2013 In rats, electrical stimulation of the dorsal raphe lowered movement thresholds and this effect could be blocked by direct cortical application of the 5-HT1A antagonist WAY-100135, indicating that serotonin is primarily acting through the 5-HT1A receptor. Serotonin 197-206 5-hydroxytryptamine receptor 1A Rattus norvegicus 151-157 17622577-1 2007 Hypothalamic proopiomelanocortin (POMC) neurons play a critical role in the regulation of energy balance, and there is a convergence of critical synaptic input including GABA and serotonin on POMC neurons to regulate their output. Serotonin 179-188 pro-opiomelanocortin-alpha Mus musculus 192-196 23486969-9 2013 Together our results demonstrate that serotonin, acting through 5-HT1A receptors, plays an excitatory role in forelimb motor map expression. Serotonin 38-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 64-70 17622577-4 2007 Because 5-HT(2C) receptors mediate many of the effects of serotonin in POMC neurons, we elucidated the common signaling pathways of E(2) and 5-HT in guinea pigs using single-cell reverse transcription-polymerase chain reaction (RT-PCR), real time RT-PCR, and whole-cell patch recording. Serotonin 58-67 pro-opiomelanocortin Cavia porcellus 71-75 23208077-7 2013 However, CAS did not alter the mRNA levels of TPH or TH, both of which are rate-limiting enzymes for the synthesis of serotonin and norepinephrine in the dorsal raphe and locus coeruleus, respectively. Serotonin 118-127 tyrosine hydroxylase Rattus norvegicus 53-55 17622577-5 2007 Both 5-hydroxytryptamine(2C) (5-HT(2C)) and 5-HT(2A) receptors were coexpressed in POMC neurons. Serotonin 5-24 pro-opiomelanocortin-alpha Mus musculus 83-87 17274026-7 2007 Serotonin release from platelets reconstituted in plasma deficient in either coagulation factor V, VIII, IX, or XII was delayed. Serotonin 0-9 cytochrome c oxidase subunit 8A Homo sapiens 99-103 23363473-2 2013 VMAT2 translocates dopamine and serotonin into synaptic vesicles and is essential for motor control, stable mood, and autonomic function. Serotonin 32-41 solute carrier family 18 member A2 Homo sapiens 0-5 17637084-7 2007 Serotonergic neurons originating in the raphe nuclei and glucagon-like peptide-1-expressing neurons in the hindbrain may be among the targets of these messengers, because serotonin (5-HT), acting through the 5-HT2C receptor, and glucagon-like peptide-1 have recently emerged as neurochemical mediators of LPS anorexia. Serotonin 171-180 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 208-223 23087044-5 2013 In the stomach, IA-2 and IA-2beta were expressed in GECs that secrete serotonin, somatostatin, and cholecystokinin/gastrin-1. Serotonin 70-79 protein tyrosine phosphatase, receptor type, N Rattus norvegicus 16-20 23336052-3 2013 Here, we showed that expression of serotonin type 4 receptors (5-HT(4)Rs) constitutively (without agonist stimulation) induced APP cleavage by the alpha-secretase ADAM10 and the release of neuroprotective sAPPalpha in HEK-293 cells and cortical neurons. Serotonin 35-44 ADAM metallopeptidase domain 10 Homo sapiens 163-169 17452372-3 2007 Removal of the serotonin afferents, or dampening of serotonin neuron activity by 5-HT1A and 5-HT1B agonist drugs, resulted in a near-complete block of the L-DOPA-induced dyskinesias, suggesting that dysregulated dopamine release from serotonin terminals is the prime trigger of dyskinesia in the rat Parkinson"s disease model. Serotonin 52-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 81-87 17452372-3 2007 Removal of the serotonin afferents, or dampening of serotonin neuron activity by 5-HT1A and 5-HT1B agonist drugs, resulted in a near-complete block of the L-DOPA-induced dyskinesias, suggesting that dysregulated dopamine release from serotonin terminals is the prime trigger of dyskinesia in the rat Parkinson"s disease model. Serotonin 52-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 81-87 23336052-3 2013 Here, we showed that expression of serotonin type 4 receptors (5-HT(4)Rs) constitutively (without agonist stimulation) induced APP cleavage by the alpha-secretase ADAM10 and the release of neuroprotective sAPPalpha in HEK-293 cells and cortical neurons. Serotonin 63-67 ADAM metallopeptidase domain 10 Homo sapiens 163-169 23336052-5 2013 Interestingly, we demonstrated that 5-HT(4) receptors physically interacted with the mature form of ADAM10. Serotonin 36-40 ADAM metallopeptidase domain 10 Homo sapiens 100-106 24117430-1 2013 Diamine oxidase (DAO), the enzyme that is responsible for amine biodegradation in animals, plants and humans, catalyses the biotransformation of amines such as histamine (HA), putrescine, 1-phenylethylamine, tyrosine, tryptamine, serotonine and spermine. Serotonin 230-240 amine oxidase copper containing 1 Homo sapiens 0-15 17532569-4 2007 In this study, HPLC methods were used to investigate the effects of AM and CGRP on the basal and K+-evoked release of serotonin, glutamate (Glu), aspartate (Asp), glycine (Gly) and gamma amino butyric acid (GABA) from the slices prepared from the rat spinal cord. Serotonin 118-127 calcitonin-related polypeptide alpha Rattus norvegicus 75-79 24117430-1 2013 Diamine oxidase (DAO), the enzyme that is responsible for amine biodegradation in animals, plants and humans, catalyses the biotransformation of amines such as histamine (HA), putrescine, 1-phenylethylamine, tyrosine, tryptamine, serotonine and spermine. Serotonin 230-240 amine oxidase copper containing 1 Homo sapiens 17-20 23034390-7 2012 The contraction to serotonin of conduit and intralobar pulmonary arteries from MCT-treated rats exhibited greater sensitivity to nifedipine (1 muM), an l-type Ca(2+) channel blocker, and NFA (30 or 100 muM, with or without 10 muM indomethacin to inhibit cyclooxygenases) or T16A(Inh)-A01 (10 muM), TMEM16A/Cl(Ca) channel inhibitors, than that of control animals. Serotonin 19-28 anoctamin 1 Rattus norvegicus 298-305 17372973-5 2007 In vivo binding in both models was studied before and after presumably having increased interstitial 5HT concentrations using tranylcypromine (TCP), which inhibits the enzyme (monoamine oxidase, MAO), that degrades 5HT. Serotonin 215-218 monoamine oxidase A Rattus norvegicus 195-198 22955057-0 2012 RhoA localization with caveolin-1 regulates vascular contractions to serotonin. Serotonin 69-78 ras homolog family member A Mus musculus 0-4 17383106-3 2007 In this study, we show by in situ hybridization that a low but significant fraction of serotonergic neurons in the raphe nuclei of mice contains CB1 mRNA as illustrated by the coexpression with the serotonergic marker gene tryptophane hydroxylase 2, the rate limiting enzyme for the serotonin synthesis. Serotonin 283-292 cannabinoid receptor 1 (brain) Mus musculus 145-148 17383106-5 2007 Our findings indicate that the CB1-mediated regulation of serotonin release can depend in part on a direct cross-talk between the two systems at single cell level, which might lead to functional implications in the modulation of emotional states. Serotonin 58-67 cannabinoid receptor 1 (brain) Mus musculus 31-34 22955057-2 2012 This latter process is regulated by the rhoA/rho kinase pathway and activated by serotonin. Serotonin 81-90 ras homolog family member A Mus musculus 40-44 17450135-0 2007 Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Serotonin 0-9 netrin 1 Mus musculus 71-79 22955057-4 2012 We hypothesized that serotonin differentially compartmentalizes rhoA within caveolar versus noncaveolar lipid rafts to regulate sustained vascular contractions. Serotonin 21-30 ras homolog family member A Mus musculus 64-68 22955057-6 2012 RhoA-dependent contractions in response to serotonin were markedly augmented in arteries from cav-1 KO mice despite a modest reduction in rhoA expression compared with WT. Serotonin 43-52 ras homolog family member A Mus musculus 0-4 22955057-7 2012 We found that under basal conditions, rhoA in WT arteries was primarily localized within high-density sucrose gradient fractions but temporally shifted to low-density fractions in response to serotonin. Serotonin 192-201 ras homolog family member A Mus musculus 38-42 17189653-3 2007 In the present work we analyzed the effect on food intake and memory retention induced by Ghr after serotonin (5-HT) availability modification at the serotoninergic synapses. Serotonin 100-109 ghrelin and obestatin prepropeptide Rattus norvegicus 90-93 22861201-3 2012 However, amantadine and dextromethorphan are also thought to block serotonin (5-HT) uptake and cause 5-HT overflow, leading to stimulation of 5-HT(1A) receptors, which has been shown to reduce LID. Serotonin 67-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 142-149 23035083-0 2012 Double dissociation between regulation of conditioned disgust and taste avoidance by serotonin availability at the 5-HT(3) receptor in the posterior and anterior insular cortex. Serotonin 85-94 5-hydroxytryptamine receptor 3A Rattus norvegicus 115-131 21769100-0 2012 Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response. Serotonin 63-72 solute carrier family 22 (organic cation transporter), member 2 Mus musculus 0-28 22710353-5 2012 In the present study, we found abnormalities in serotonin (5-HT) signaling, including decreased expression of 5-HT(1A) receptor (5-HT(1A)-R) mRNA in the medial prefrontal cortex (mPFC) and 5-HT content in the hippocampus at postnatal week (PW) 4. Serotonin 48-57 5-hydroxytryptamine receptor 1A Rattus norvegicus 110-117 22710353-5 2012 In the present study, we found abnormalities in serotonin (5-HT) signaling, including decreased expression of 5-HT(1A) receptor (5-HT(1A)-R) mRNA in the medial prefrontal cortex (mPFC) and 5-HT content in the hippocampus at postnatal week (PW) 4. Serotonin 48-57 5-hydroxytryptamine receptor 1A Rattus norvegicus 129-136 22988760-2 2012 Calmodulin inhibitors trifluoperazine and W-13 suppress vasoconstriction of the rat aorta in response to norepinephrine, serotonin, and serotonin 5HT1A- and 5HT2A-receptor agonists (8-OH-DPAT and DOI, respectively) and do not affect the vasodilatory effect of 5HT1B-, 5HT2B-, and 5HT4-receptors. Serotonin 121-130 calmodulin 1 Rattus norvegicus 0-10 22988760-5 2012 The inhibitor of calmodulin-dependent myosin light chain kinase KN93 decreases the vasoconstrictive response in response to norepinephrine and serotonin by only 20%. Serotonin 143-152 calmodulin 1 Rattus norvegicus 17-27 22454151-8 2012 Kiss1 administration significantly increased the c-fos mRNA levels in the raphe nuclei (2.5-fold, P < 0.001) and genes involved in the regulation of serotonin levels (pet1 and slc6a4a; 3.3- and 2.2-fold, P < 0.01). Serotonin 152-161 FEV transcription factor, ETS family member Danio rerio 170-174 22318950-0 2012 Mammary gland serotonin regulates parathyroid hormone-related protein and other bone-related signals. Serotonin 14-23 parathyroid hormone like hormone Homo sapiens 34-69 22500608-0 2012 Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Serotonin 0-9 catechol-O-methyltransferase Homo sapiens 53-81 22500608-3 2012 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). Serotonin 18-27 catechol-O-methyltransferase Homo sapiens 42-70 22500608-3 2012 Here we show that serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (K(i) = 44 muM). Serotonin 18-27 catechol-O-methyltransferase Homo sapiens 72-76 22500608-5 2012 Binding of serotonin to the catalytic site inhibits the access of SAM, thus preventing methylation of COMT substrates. Serotonin 11-20 catechol-O-methyltransferase Homo sapiens 102-106 22500608-7 2012 Our results suggest that inhibition of COMT via serotonin binding contributes to pain hypersensitivity, providing additional strategies for the treatment of clinical pain conditions. Serotonin 48-57 catechol-O-methyltransferase Homo sapiens 39-43 22209919-2 2012 Peripherally released 5HT induces thermal hyperalgesia, possibly via modulation of the transient receptor potential V1 (TRPV1) channel, which is gated by various noxious stimuli, including capsaicin. Serotonin 22-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-118 22209919-2 2012 Peripherally released 5HT induces thermal hyperalgesia, possibly via modulation of the transient receptor potential V1 (TRPV1) channel, which is gated by various noxious stimuli, including capsaicin. Serotonin 22-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-125 22209919-3 2012 We previously reported in vitro that 5HT increases calcium accumulation in the capsaicin-sensitive population of sensory neurons with a corresponding increase in proinflammatory neuropeptide release, and both are antagonized by pretreatment with 5HT(2A) and 5HT(3) antagonists, as well as the anti-migraine drug sumatriptan. Serotonin 37-40 5-hydroxytryptamine receptor 2A Rattus norvegicus 246-252 22209919-4 2012 In the current study, we extended these findings in vivo using the rat hind paw thermal assay to test the hypothesis that peripheral 5HT enhances TRPV1-evoked thermal hyperalgesia that can be attenuated with 5HT(2A) and 5HT(3) receptor antagonists, as well as sumatriptan. Serotonin 133-136 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 146-151 22209919-4 2012 In the current study, we extended these findings in vivo using the rat hind paw thermal assay to test the hypothesis that peripheral 5HT enhances TRPV1-evoked thermal hyperalgesia that can be attenuated with 5HT(2A) and 5HT(3) receptor antagonists, as well as sumatriptan. Serotonin 133-136 5-hydroxytryptamine receptor 2A Rattus norvegicus 208-214 22209919-7 2012 We report that 5HT pretreatment enhances TRPV1-evoked thermal hyperalgesia, which is attenuated with local pretreatment with ketanserin, granisetron, or sumatriptan. Serotonin 15-18 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 22209919-9 2012 Overall, our results provide in vivo evidence supporting an enhancing role of 5HT on TRPV1-evoked thermal hyperalgesia, which can be attenuated by peripheral serotonergic intervention. Serotonin 78-81 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-90 22202668-7 2012 In contrast, the level of serotonin, glutamate, GABA, and taurine were increased by more than 50% in the striatum of Ca(v)1.3 null mice. Serotonin 26-35 calcium channel, voltage-dependent, L type, alpha 1D subunit Mus musculus 117-125 23951413-5 2012 Adding to the complexity of the system are the studies that suggested Lrp5 regulated bone mass through a gut-bone endocrine signaling system involving Lrp5 mediated control of gut serotonin synthesis. Serotonin 180-189 low density lipoprotein receptor-related protein 5 Mus musculus 70-74 23951413-5 2012 Adding to the complexity of the system are the studies that suggested Lrp5 regulated bone mass through a gut-bone endocrine signaling system involving Lrp5 mediated control of gut serotonin synthesis. Serotonin 180-189 low density lipoprotein receptor-related protein 5 Mus musculus 151-155 22029710-4 2012 KEY RESULTS: Serotonin-containing perikarya represented ~10% of all PGP 9.5-positive myenteric neurons. Serotonin 13-22 ubiquitin carboxy-terminal hydrolase L1 Mus musculus 68-75 23264832-1 2012 Dopa decarboxylase (DDC) is a pyridoxal 5"-phosphate (PLP)-dependent enzyme that by catalyzing the decarboxylation of L-Dopa and L-5-hydroxytryptophan produces the neurotransmitters dopamine and serotonin. Serotonin 195-204 pyridoxal phosphatase Homo sapiens 54-57 23209830-2 2012 We found that a chicken essence beverage, which is popular among Southeast Asians as a traditional remedy and a rich source of DKPs, inhibited the serotonin transporter (SERT) and suppressed serotonin uptake from rat brain synaptosomes, which prompted us to isolate and identify the active substance(s). Serotonin 147-156 solute carrier family 6 member 4 Gallus gallus 170-174 22808145-4 2012 The heterotrimeric G proteins GOA-1 (Galpha(o)) and EGL-30 (Galpha(q)) mediate serotonin signaling as well as serotonin biosynthesis in C. elegans. Serotonin 79-88 Guanine nucleotide-binding protein G(o) subunit alpha Caenorhabditis elegans 30-47 22808145-4 2012 The heterotrimeric G proteins GOA-1 (Galpha(o)) and EGL-30 (Galpha(q)) mediate serotonin signaling as well as serotonin biosynthesis in C. elegans. Serotonin 110-119 Guanine nucleotide-binding protein G(o) subunit alpha Caenorhabditis elegans 30-47 22448217-2 2012 Serotonin exerts its anorectic effects mainly through the 5-HT(1B), 5-HT(2C) and 5-HT(6) receptors and these are therefore receiving increasing attention as principal pharmacotherapeutic targets for the treatment of obesity. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 68-75 21735137-4 2011 Furthermore, 5HT(3A) receptor agonist 1-(m-chlorophenyl)-biguanide (mCPBG) impaired learning in the passive avoidance task followed by reduction of 5HT(3A) receptor expression, 5HT and ACh levels. Serotonin 13-16 5-hydroxytryptamine receptor 3A Rattus norvegicus 148-154 21896313-1 2011 GTP cyclohydrolase 1 (GCH1) is the initial and rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, which is an essential cofactor for biosynthetic enzymes of dopamine, serotonin, and nitric oxide. Serotonin 181-190 GTP cyclohydrolase 1 Homo sapiens 0-20 21896313-1 2011 GTP cyclohydrolase 1 (GCH1) is the initial and rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, which is an essential cofactor for biosynthetic enzymes of dopamine, serotonin, and nitric oxide. Serotonin 181-190 GTP cyclohydrolase 1 Homo sapiens 22-26 20818612-2 2011 Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Serotonin 0-9 solute carrier family 18 member A2 Homo sapiens 242-247 21737202-3 2011 As 5HT is released in the periphery during inflammation and evokes thermal hyperalgesia, and TRPV1 is essential for thermal hyperalgesia, we hypothesized that 5HT increases the activity of capsaicin-sensitive trigeminal neurons and that this increase can be attenuated by pharmacologically targeting peripheral 5HT receptors. Serotonin 159-162 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-98 21737202-7 2011 5HT pretreatment evoked a significant increase in calcium accumulation in capsaicin-sensitive trigeminal neurons and enhanced capsaicin-evoked CGRP release, but had no significant effect when given alone. Serotonin 0-3 calcitonin-related polypeptide alpha Rattus norvegicus 143-147 21554895-6 2011 We have suggested that serotonin (5-HT) in the perifornical LH inhibits sexual behavior by inhibiting orexin/hypocretin neurons (OX/HCRT), which would otherwise excite neurons in the mesocorticolimbic DA tract. Serotonin 23-32 hypocretin neuropeptide precursor Homo sapiens 102-108 21554895-6 2011 We have suggested that serotonin (5-HT) in the perifornical LH inhibits sexual behavior by inhibiting orexin/hypocretin neurons (OX/HCRT), which would otherwise excite neurons in the mesocorticolimbic DA tract. Serotonin 23-32 hypocretin neuropeptide precursor Homo sapiens 132-136 21607742-1 2011 Monoamine oxidase (MAO) A is the major metabolizing enzyme of serotonin (5-hydroxytryptamine, 5-HT) which regulates early brain development. Serotonin 62-71 monoamine oxidase A Mus musculus 0-25 21607742-1 2011 Monoamine oxidase (MAO) A is the major metabolizing enzyme of serotonin (5-hydroxytryptamine, 5-HT) which regulates early brain development. Serotonin 73-92 monoamine oxidase A Mus musculus 0-25 21521772-0 2011 Type 1 diabetes-induced hyper-responsiveness to 5-hydroxytryptamine in rat pulmonary arteries via oxidative stress and induction of cyclooxygenase-2. Serotonin 48-67 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 132-148 21371861-8 2011 Q3GA inhibited the generation of hydrogen peroxide from the MAO-A reaction with serotonin. Serotonin 80-89 monoamine oxidase A Mus musculus 60-65 21320265-7 2011 RESULTS: Hyperserotoninergic rats had significantly lower body weight (-7.4 and -6.8%) and plasma leptin levels (-44 and -38%) than controls, after both short- and long-term serotonin treatment, respectively, whereas plasma ghrelin levels were unaffected. Serotonin 14-23 leptin Rattus norvegicus 98-104 21320265-7 2011 RESULTS: Hyperserotoninergic rats had significantly lower body weight (-7.4 and -6.8%) and plasma leptin levels (-44 and -38%) than controls, after both short- and long-term serotonin treatment, respectively, whereas plasma ghrelin levels were unaffected. Serotonin 14-23 ghrelin and obestatin prepropeptide Rattus norvegicus 224-231 21519306-10 2011 CONCLUSION: This study suggests that gene interactions between genetic variants in COMT, 5-HTR2A and tryptophan hydroxylase gene would be associated with ASPD and influence the dopamine rewards pathways and modulate serotonin levels in ASPD. Serotonin 216-225 catechol-O-methyltransferase Homo sapiens 83-87 21472823-7 2011 Combined directed expression of Gata2, proneural gene Mash1, and forkhead transcription factor Foxa2 further enhanced serotonergic neural differentiation, resulting in a 10-fold increase in serotonin content. Serotonin 190-199 GATA binding protein 2 Homo sapiens 32-37 21472823-7 2011 Combined directed expression of Gata2, proneural gene Mash1, and forkhead transcription factor Foxa2 further enhanced serotonergic neural differentiation, resulting in a 10-fold increase in serotonin content. Serotonin 190-199 achaete-scute family bHLH transcription factor 1 Homo sapiens 54-59 21327820-7 2011 Zebrafish calbindin-immunoreactive neurons are serotonin-negative, with at least some being choline acetyltransferase (ChAT)-positive, in contrast to the sculpin in which cells are generally smaller than the average enteric neuron and are serotonin-positive and ChAT-negative. Serotonin 47-56 calbindin 1 Danio rerio 10-19 21327820-7 2011 Zebrafish calbindin-immunoreactive neurons are serotonin-negative, with at least some being choline acetyltransferase (ChAT)-positive, in contrast to the sculpin in which cells are generally smaller than the average enteric neuron and are serotonin-positive and ChAT-negative. Serotonin 239-248 calbindin 1 Danio rerio 10-19 21299657-1 2011 In the Syrian hamster dorsal and median raphe nuclei, the tryptophan hydroxylase 2 gene (tph2), which codes the rate-limiting enzyme of serotonin synthesis, displays daily variations in its expression in animals entrained to a long but not to a short photoperiod. Serotonin 136-145 tryptophan 5-hydroxylase 2 Mesocricetus auratus 58-82 21299657-1 2011 In the Syrian hamster dorsal and median raphe nuclei, the tryptophan hydroxylase 2 gene (tph2), which codes the rate-limiting enzyme of serotonin synthesis, displays daily variations in its expression in animals entrained to a long but not to a short photoperiod. Serotonin 136-145 tryptophan 5-hydroxylase 2 Mesocricetus auratus 89-93 21448290-10 2011 These results suggest that the dysbindin deficiency could be an essential genetic factor that causes synaptic hypersensitivity to dopamine and serotonin. Serotonin 143-152 dystrobrevin binding protein 1 Mus musculus 31-40 21042794-9 2011 An acute treatment with the CB1 antagonist rimonabant completely abolished the emotional phenotype of FAAH(-/-) mice and prevented the K(+)-stimulated release of serotonin in their FC and vHIPP, without producing any effect in wt mice. Serotonin 162-171 cannabinoid receptor 1 (brain) Mus musculus 28-31 21226885-10 2011 Extracellular serotonin levels decrease during the first three neonatal weeks as SERT expression increases. Serotonin 14-23 sodium-dependent serotonin transporter Cavia porcellus 81-85 21456501-7 2011 Concerning monoamines in urine, we have observed significantly increased serotonin levels in HDC group compared to control (p < 0.05) and LDC animals (p < 0.01). Serotonin 73-82 histidine decarboxylase Rattus norvegicus 93-96 21073553-6 2011 The hyperlocomotion of GluA1-/- mice was normalised to the level of wild-type mice within 5-6 h, after which their locomotion followed normal circadian rhythm and was not affected by acute or chronic treatments with the selective serotonin reuptake inhibitor escitalopram. Serotonin 230-239 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 23-28 21853036-0 2011 Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12. Serotonin 0-9 C-X-C motif chemokine ligand 12 Homo sapiens 81-87 21083617-4 2010 Fluoxetine and serotonin enhanced the alkaline phosphatase activity in the cell culture medium from cultured LS8 cells, whereas the expression of enamelin (Enam), amelogenin (Amel), and matrix metalloproteinase-20 (MMP-20) were all significantly down-regulated. Serotonin 15-24 matrix metallopeptidase 20 Homo sapiens 215-221 20828585-12 2010 In mice lacking the monoamine oxidase-A gene, the role of serotonin degradation in cardiac hypertrophy was confirmed. Serotonin 58-67 monoamine oxidase A Mus musculus 20-39 20573591-0 2010 Hypothalamic paraventricular 5-hydroxytryptamine inhibits the effects of ghrelin on eating and energy substrate utilization. Serotonin 29-48 ghrelin and obestatin prepropeptide Rattus norvegicus 73-80 20641662-0 2004 (+)-2-Hydroxy-3-isobutyl-9-(3-[(18)F]fluoropropoxy)-10-methoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine Vesicular monoamine transporter (VMAT2) is present in brain monoaminergic neurons and is responsible for collecting neurotransmitters (dopamine, norepinephrine, and serotonin) from the cytoplasm and storing them in vesicles for synaptic release (1). Serotonin 275-284 solute carrier family 18 member A2 Homo sapiens 143-148 20637741-2 2010 Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by 5-HT3 receptor antagonists in rats following spinal nerve ligation (SNL) but not sham operation. Serotonin 44-53 5-hydroxytryptamine receptor 3A Rattus norvegicus 181-195 21090244-8 2010 These data allow us to conclude that the selective silencer of 5-HT(1A) receptor, Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A) receptor transcriptional regulation. Serotonin 178-187 coiled-coil and C2 domain containing 1A Mus musculus 63-80 21090244-8 2010 These data allow us to conclude that the selective silencer of 5-HT(1A) receptor, Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A) receptor transcriptional regulation. Serotonin 178-187 coiled-coil and C2 domain containing 1A Mus musculus 82-89 21090244-8 2010 These data allow us to conclude that the selective silencer of 5-HT(1A) receptor, Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A) receptor transcriptional regulation. Serotonin 178-187 coiled-coil and C2 domain containing 1A Mus musculus 235-252 20181818-5 2010 Our method is based on the serotonin 2C receptor (5-hydroxytryptamine(2C); 5HT(2C)) transcript, an RNA editing substrate in which up to five adenosines are modified. Serotonin 50-69 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 75-81 20211152-0 2010 Leptin accumulation in hypothalamic and dorsal raphe neurons is inversely correlated with brain serotonin content. Serotonin 96-105 leptin Rattus norvegicus 0-6 20211152-6 2010 Low brain serotonin immunoreactivity was found in all animals with high neuronal leptin accumulation at the raphe nucleus, independently of their age. Serotonin 10-19 leptin Rattus norvegicus 81-87 20211152-7 2010 In contrast, high brain serotonin immunoreactivity was accompanied by a low neuronal accumulation of leptin. Serotonin 24-33 leptin Rattus norvegicus 101-107 20211152-9 2010 Serotonin depletion resulted in an enhanced accumulation of leptin in raphe as well as in hypothalamic neurons. Serotonin 0-9 leptin Rattus norvegicus 60-66 20211152-10 2010 These findings indicate that serotonin regulates leptin uptake by neuronal cell bodies of the dorsal raphe and hypothalamus, this suggests that at least part of the effects of serotonin may be mediated by the regulation of neuronal trafficking in the brain. Serotonin 29-38 leptin Rattus norvegicus 49-55 20211152-10 2010 These findings indicate that serotonin regulates leptin uptake by neuronal cell bodies of the dorsal raphe and hypothalamus, this suggests that at least part of the effects of serotonin may be mediated by the regulation of neuronal trafficking in the brain. Serotonin 176-185 leptin Rattus norvegicus 49-55 20333369-1 2010 The low-density lipoprotein receptor-related protein (Lrp)-5 regulates osteoblast proliferation and bone formation through its expression in duodenum by modifying the gut serotonin-bone endocrine axis. Serotonin 171-180 low density lipoprotein receptor-related protein 5 Mus musculus 4-60 20156421-0 2010 Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) mice. Serotonin 10-19 plasminogen activator, tissue Mus musculus 111-118 20156421-6 2010 These patterns are accompanied by decreased levels of serotonin in several brain regions important in behavioral regulation in the tPA(-/-) mice compared to control animals. Serotonin 54-63 plasminogen activator, tissue Mus musculus 131-134 20156421-7 2010 Systemic administration of fluoxetine reversed the behavioral disinhibition of tPA(-/-) mice, further supporting an important alteration in behavior regulation mediated by serotonin systems as underappreciated but important element of the behavioral phenotype of these animals. Serotonin 172-181 plasminogen activator, tissue Mus musculus 79-82 20384866-0 2010 Analysis of FcgammaRIIA cytoplasmic tail requirements in signaling for serotonin secretion: evidence for an ITAM-dependent, PI3K-dependent pathway. Serotonin 71-80 Fc gamma receptor IIa Homo sapiens 12-23 20384866-1 2010 The human Fc receptor, FcgammaRIIA, is known to mediate phagocytosis and endocytosis, yet the greatest numbers of these receptors are expressed on the surface of non-phagocytic platelets, where they are involved in serotonin secretion. Serotonin 215-224 Fc gamma receptor IIa Homo sapiens 23-34 20384866-7 2010 Therefore, we investigated the sequence requirements for another important FcgammaRIIA-mediated signaling event, serotonin secretion, using Rat Basophilic Leukemia (RBL-2H3) cells transfected with wildtype (WT) FcgammaRIIA or mutant FcgammaRIIA. Serotonin 113-122 Fc gamma receptor IIa Homo sapiens 75-86 20384866-8 2010 Stimulation of cells expressing WT FcgammaRIIA induced release of serotonin at a level 7-fold greater than that in nonstimulated WT FcgammaRIIA-transfected cells or nontransfected RBL cells. Serotonin 66-75 Fc gamma receptor IIa Homo sapiens 35-46 20006676-5 2010 Together, findings from this and our previous studies indicate that PKC53E and PKC98E differentially regulate fly alcohol sensitivity through independent modulation of conserved serotonin and neuropeptide Y-like systems. Serotonin 178-187 Protein C kinase 98E Drosophila melanogaster 79-85 19796699-0 2010 Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar. Serotonin 26-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 36-42 19747415-4 2010 Serotonin derivatives N-(p-coumaroyl)serotonin and N-feruloylserotonin exerted a protective effect on high glucose-induced cell death, inhibited the activation of caspase-3 which represents the last and crucial step within the cascade of events leading to apoptosis, and inhibited the overproduction of the mitochondrial superoxide, which represents the most dangerous radical produced by hyperglycaemia, by acting as scavengers of the superoxide radical. Serotonin 0-9 caspase 3 Rattus norvegicus 163-172 19855932-11 2009 More interestingly, genetic epistasis suggests that hlh-11 may function to regulate serotonin-mediated egg laying at the downstream of tax-6. Serotonin 84-93 Serine/threonine-protein phosphatase 2B catalytic subunit Caenorhabditis elegans 135-140 19607848-6 2009 MAPKK1 and PP-1G are known 5-HT(1A) R-dependent signaling compounds and are in agreement with receptor knock-out and septin-5 is involved in serotonin transport, although regulation by 5-HT(1A) R has not been reported. Serotonin 141-150 mitogen-activated protein kinase kinase 1 Mus musculus 0-6 19607848-6 2009 MAPKK1 and PP-1G are known 5-HT(1A) R-dependent signaling compounds and are in agreement with receptor knock-out and septin-5 is involved in serotonin transport, although regulation by 5-HT(1A) R has not been reported. Serotonin 141-150 protein phosphatase 1 catalytic subunit gamma Mus musculus 11-16 19288193-9 2009 Ketanserin, an antagonist of 5-HT(2A), reversed the effect of 5HT on 10% ethanol induced ALDH activity in hepatocytes. Serotonin 62-65 aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus 89-93 19690620-1 2009 BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance. Serotonin 106-115 catechol-O-methyltransferase Homo sapiens 82-86 19692608-3 2009 Here we show that neonatal Lmx1b(flox/flox;ePet-Cre/+) mice (also called Lmx1b(f/f/p) mice), which selectively lack serotonin neurons, display frequent and severe apnea lasting as long as 55 s. This was associated with a marked decrease in ventilation to less than one-half of normal. Serotonin 116-125 LIM homeobox transcription factor 1 beta Mus musculus 27-32 19675243-4 2009 Using whole cell recordings in brain slices of the rat medial prefrontal cortex, we observed that serotonin directly inhibits layer II/III pyramidal neurons through 5-HT(1A) receptors across postnatal development (postnatal days 6-96). Serotonin 98-107 5-hydroxytryptamine receptor 1A Rattus norvegicus 165-172 19541673-7 2009 In contrast, the 5-HT1A receptor exhibited a significantly preferential coupling for Galpha(16/i3) compared with Galpha(16/i2) when serotonin was used as a ligand. Serotonin 132-141 G protein subunit alpha 15 Homo sapiens 85-97 19541673-7 2009 In contrast, the 5-HT1A receptor exhibited a significantly preferential coupling for Galpha(16/i3) compared with Galpha(16/i2) when serotonin was used as a ligand. Serotonin 132-141 G protein subunit alpha 15 Homo sapiens 113-125 19457070-4 2009 TNF-alpha shed in response to PrP(C) acts as a second message signal, eliciting serotonin (5-HT) or norepinephrine (NE) degradation in 1C11(5-HT) or 1C11(NE) cells, respectively. Serotonin 80-89 prion protein Mus musculus 30-36 19398169-6 2009 Considering the similar changes in serotonin(5-HT) and platelet activation through phosphoinositide (PI)-phospholipase C(PLC) pathway, we guess that PI-PLC signal transduction pathway is a common pathogenesis between depression and post-MI, which mediated by 5-HT resulting in the platelet activation. Serotonin 35-44 phospholipase C beta 1 Homo sapiens 149-155 19649279-5 2009 Functional experiments showed that the Cx-mimetic peptide targeted against Cx 37 and Cx 43 ((37,43)Gap27) (1) reduced contractile and calcium responses to serotonin (5-HT) simultaneously recorded in pulmonary arteries and (2) abolished the diffusion in SMC of carboxyfluorescein-AM loaded in EC. Serotonin 155-164 gap junction protein alpha 1 Homo sapiens 85-90 19455435-1 2009 Changes in representative dopamine (D(1), D(2), and D(4)) and serotonin (5-HT(1A) and 5-HT(2A)) receptors that have been implicated in the pathophysiology and treatment of schizophrenia were autoradiographically quantified after subchronic phencyclidine (PCP) treatment (2 mg/kg for 7 days, bi-daily followed by 7 days drug free). Serotonin 62-71 5-hydroxytryptamine receptor 1A Rattus norvegicus 73-80 19371745-2 2009 In vertebrates, DMH serotonin (5-HT) concentrations increase rapidly in response to acute stressors or corticosterone (CORT). Serotonin 20-29 cortistatin Rattus norvegicus 119-123 19548619-7 2009 Inhibition of serotonin response by ketanserin, a 5HT2A receptor blocker, did not depend on the presence of 15 mM KCl. Serotonin 14-23 5-hydroxytryptamine receptor 2A Rattus norvegicus 50-55 19076925-6 2009 The obtained results demonstrated that the administration of a neurotoxic binge dose of MDMA to an adolescent rat model previously treated with the specific MAO-A inhibitor, clorgyline, resulted in synergistic effects on serotonin- (5-HT) mediated behaviour and body temperature, provoking high mortality. Serotonin 221-230 monoamine oxidase A Rattus norvegicus 157-162 19162038-0 2009 Genetic deletion of MAO-A promotes serotonin-dependent ventricular hypertrophy by pressure overload. Serotonin 35-44 monoamine oxidase A Mus musculus 20-25 19095720-1 2009 Pinoline, 6-methoxy-1,2,3,4-tetrahydro-beta-carboline, is a serotonin analog that selectively inhibits the activity of monoamine oxidase-A and shows antidepressant activity. Serotonin 60-69 monoamine oxidase A Mus musculus 119-138 18663366-0 2009 Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Serotonin 10-19 5-hydroxytryptamine receptor 6 Homo sapiens 86-106 19219064-14 2009 Hence increased synaptic serotonin, via serotonin reuptake inhibition or 5-HT(1A) activation, together with increased NA, would appear to produce hypophagia. Serotonin 25-34 5-hydroxytryptamine receptor 1A Rattus norvegicus 73-80 18996226-10 2009 In the serotonin developmental cascade, FGFR2 was robustly expressed at each stage. Serotonin 7-16 fibroblast growth factor receptor 2 Macaca mulatta 40-45 19005016-6 2009 These results indicate that serotonin signaling via serotonin 2CR is necessary for the full satiating effects of CCK and GLP-1. Serotonin 28-37 glucagon Mus musculus 121-126 19301552-2 2009 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression in myxomatous valves could implicate an autocrine serotonin signaling mechanism. Serotonin 70-79 tryptophan hydroxylase 1 Canis lupus familiaris 0-24 19301552-2 2009 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression in myxomatous valves could implicate an autocrine serotonin signaling mechanism. Serotonin 70-79 tryptophan hydroxylase 1 Canis lupus familiaris 26-30 19301552-2 2009 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression in myxomatous valves could implicate an autocrine serotonin signaling mechanism. Serotonin 160-169 tryptophan hydroxylase 1 Canis lupus familiaris 0-24 19301552-2 2009 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression in myxomatous valves could implicate an autocrine serotonin signaling mechanism. Serotonin 160-169 tryptophan hydroxylase 1 Canis lupus familiaris 26-30 19301552-3 2009 Studies in cultured cells demonstrate a close coupling between serotonin and transforming growth factor beta1 (TGFbeta1) signaling. Serotonin 63-72 transforming growth factor beta-1 proprotein Canis lupus familiaris 111-119 19301552-11 2009 CONCLUSION: The expression of TPH1 by canine and human myxomatous valves demonstrates a capacity for local serotonin production. Serotonin 107-116 tryptophan hydroxylase 1 Canis lupus familiaris 30-34 19094089-8 2009 TPH2 mRNA expression in serotonin neurones was found in several nuclei, and its most abundant mRNA expression was seen in the nucleus Locus ceruleus of laying and incubating hens. Serotonin 24-33 tryptophan hydroxylase 2 Gallus gallus 0-4 19106465-1 2008 The ability of serotonin 5-HT(1A) and 5-HT(1B) receptors in the ventrolateral striatum to modulate dopamine receptor-mediated jaw movements was investigated in freely moving rats, using a magnet-sensing system combined with an intracerebral drug microinjection technique. Serotonin 15-24 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-32 18786747-1 2008 It has been proposed that the desensitization of 5-HT(1A) (5-hydroxytryptamine; serotonin) receptors following chronic therapy with selective serotonin reuptake inhibitors (SSRIs) is necessary for their therapeutic efficacy. Serotonin 59-78 5-hydroxytryptamine receptor 1A Rattus norvegicus 49-56 18616956-0 2008 The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats. Serotonin 39-48 fatty-acid amide hydrolase-like Rattus norvegicus 52-56 18592413-6 2008 In rat hippocampal neurons, prolonged (72-hour) treatment with selective serotonin reuptake inhibitors paroxetine and citalopram significantly up-regulated BDNF and PACAP expression and down-regulated PACAP receptor (PAC1 and VPAC2) expression; the tricyclic antidepressant imipramine had an opposite effect. Serotonin 73-82 adenylate cyclase activating polypeptide 1 Rattus norvegicus 165-170 18592413-6 2008 In rat hippocampal neurons, prolonged (72-hour) treatment with selective serotonin reuptake inhibitors paroxetine and citalopram significantly up-regulated BDNF and PACAP expression and down-regulated PACAP receptor (PAC1 and VPAC2) expression; the tricyclic antidepressant imipramine had an opposite effect. Serotonin 73-82 adenylate cyclase activating polypeptide 1 Rattus norvegicus 201-206 18755776-9 2008 On the right, Ca(i)(2+) levels were actively repressed through the activities of H(+)K(+) ATPase and serotonin-dependent signaling, thus identifying a novel mechanism for the known effects of serotonin on laterality. Serotonin 192-201 ATPase, H+/K+ exchanging, beta polypeptide Mus musculus 81-96 18634763-0 2008 Serotonin immunoreactivity in auditory brainstem neurons of the postnatal monoamine oxidase-A knockout mouse. Serotonin 0-9 monoamine oxidase A Mus musculus 74-93 18339223-1 2008 Serotonin 5-HT2A and 5-HT2C receptors have been implicated in the pathophysiology of obsessive-compulsive disorder (OCD) and in the mechanism mediating the anti-compulsive effects of serotonin reuptake inhibitors. Serotonin 183-192 5-hydroxytryptamine receptor 2A Rattus norvegicus 10-22 17399854-4 2008 Astrocyte-secreted GDNF enhanced neuron function as shown by local increases in synthesis of the neurotransmitters acetylcholine, dopamine and serotonin. Serotonin 143-152 glial cell derived neurotrophic factor Rattus norvegicus 19-23 18550726-9 2008 Postsynaptically, serotonin activates a hyperpolarization-activated cation channel, probably via 5-HT1A receptors. Serotonin 18-27 5-hydroxytryptamine receptor 1A Rattus norvegicus 97-103 18585703-3 2008 Evidences have demonstrated that berberine possesses central nervous system activities, particularly the ability to inhibit monoamine oxidase-A, an enzyme involved in the degradation of norepinephrine and serotonin (5-HT). Serotonin 205-214 monoamine oxidase A Mus musculus 124-143 18593914-5 2008 Serotonin does not enhance tumor cell proliferation but acts as a regulator of angiogenesis by reducing the expression of matrix metalloproteinase 12 (MMP-12) in tumor-infiltrating macrophages, entailing lower levels of angiostatin-an endogenous inhibitor of angiogenesis. Serotonin 0-9 matrix metallopeptidase 12 Mus musculus 122-149 18593914-5 2008 Serotonin does not enhance tumor cell proliferation but acts as a regulator of angiogenesis by reducing the expression of matrix metalloproteinase 12 (MMP-12) in tumor-infiltrating macrophages, entailing lower levels of angiostatin-an endogenous inhibitor of angiogenesis. Serotonin 0-9 matrix metallopeptidase 12 Mus musculus 151-157 18593914-8 2008 In conclusion, we show how serotonin regulates angiogenesis in s.c. colon cancer allografts by influencing MMP-12 expression in tumor-infiltrating macrophages, thereby affecting the production of circulating angiostatin. Serotonin 27-36 matrix metallopeptidase 12 Mus musculus 107-113 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 0-9 glial cell derived neurotrophic factor Rattus norvegicus 25-68 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 0-9 glial cell derived neurotrophic factor Rattus norvegicus 70-74 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 0-9 fibroblast growth factor receptor 2 Rattus norvegicus 119-154 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 0-9 fibroblast growth factor receptor 2 Rattus norvegicus 156-161 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 11-15 glial cell derived neurotrophic factor Rattus norvegicus 25-68 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 11-15 glial cell derived neurotrophic factor Rattus norvegicus 70-74 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 11-15 fibroblast growth factor receptor 2 Rattus norvegicus 119-154 18363829-0 2008 Serotonin (5-HT) induces glial cell line-derived neurotrophic factor (GDNF) mRNA expression via the transactivation of fibroblast growth factor receptor 2 (FGFR2) in rat C6 glioma cells. Serotonin 11-15 fibroblast growth factor receptor 2 Rattus norvegicus 156-161 18363829-1 2008 We previously reported that serotonin (5-HT) increased glial cell line-derived neurotrophic factor (GDNF) release in a 5-HT(2) receptor (5-HT(2)R) and mitogen-activated protein kinase kinase/extracellular signal-related kinase (MEK/ERK)-dependent manner in rat C6 glioma cells (C6 cells), a model of astrocytes. Serotonin 28-37 glial cell derived neurotrophic factor Rattus norvegicus 55-98 18363829-1 2008 We previously reported that serotonin (5-HT) increased glial cell line-derived neurotrophic factor (GDNF) release in a 5-HT(2) receptor (5-HT(2)R) and mitogen-activated protein kinase kinase/extracellular signal-related kinase (MEK/ERK)-dependent manner in rat C6 glioma cells (C6 cells), a model of astrocytes. Serotonin 28-37 glial cell derived neurotrophic factor Rattus norvegicus 100-104 18622042-1 2008 Recently developed antipsychotic drugs ameliorating the negative symptoms of schizophrenia act not only on dopamine D2 receptors but also on serotonin 2A (5-HT2A) and 1A (5-HT1A) receptors in specific regions of the cerebral cortex. Serotonin 141-150 5-hydroxytryptamine receptor 2A Rattus norvegicus 155-161 18622042-1 2008 Recently developed antipsychotic drugs ameliorating the negative symptoms of schizophrenia act not only on dopamine D2 receptors but also on serotonin 2A (5-HT2A) and 1A (5-HT1A) receptors in specific regions of the cerebral cortex. Serotonin 141-150 5-hydroxytryptamine receptor 1A Rattus norvegicus 171-177 18622042-5 2008 In the EC, only 22% of serotonin 5-HT2A-positive neurons were positive for serotonin 5-HT1A receptor-immunoreactivity. Serotonin 23-32 5-hydroxytryptamine receptor 2A Rattus norvegicus 33-39 18423777-16 2008 The effects of the selective ER beta agonist, WAY-200070, on dopamine and serotonin, the anxiolytic-like and antidepressant-like effects as well as the genotype specific effects on neurochemistry support that positive modulation of ER beta function may provide a novel treatment for affective disorders. Serotonin 74-83 estrogen receptor 2 (beta) Mus musculus 29-36 18602835-10 2008 While endogenous serotonin acting on 5-HT(1A) and 5-HT(2C) receptors may facilitate mechanical sensitivity in animals with a sleep deprivation-induced hypersensitivity as well as in controls, increased activation of spinal 5-HT(1A) receptors by an exogenous agonist leads to suppression of mechanical sensitivity in both conditions. Serotonin 17-26 5-hydroxytryptamine receptor 1A Rattus norvegicus 37-44 18602835-10 2008 While endogenous serotonin acting on 5-HT(1A) and 5-HT(2C) receptors may facilitate mechanical sensitivity in animals with a sleep deprivation-induced hypersensitivity as well as in controls, increased activation of spinal 5-HT(1A) receptors by an exogenous agonist leads to suppression of mechanical sensitivity in both conditions. Serotonin 17-26 5-hydroxytryptamine receptor 1A Rattus norvegicus 223-230 18513318-0 2008 Evidence for topographically organized endogenous 5-HT-1A receptor-dependent feedback inhibition of the ascending serotonin system. Serotonin 114-123 5-hydroxytryptamine receptor 1A Rattus norvegicus 50-57 18513318-1 2008 Raphe and extra-raphe 5-HT-1A receptors contribute to feedback inhibition of serotonin (5-HT) neurons; however, the endogenous function of 5-HT-1A receptor-dependent feedback inhibition remains poorly understood. Serotonin 77-86 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-29 18622081-2 2008 In particular, the neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) has been hypothesized to play a role in skeletal metabolism via its transporter (5-HTT). Serotonin 36-45 huntingtin Homo sapiens 158-161 18622081-2 2008 In particular, the neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) has been hypothesized to play a role in skeletal metabolism via its transporter (5-HTT). Serotonin 47-66 huntingtin Homo sapiens 158-161 17664042-8 2008 These results also provide evidence that activation of NTR1 in the RVM produces antinociception through spinal release of norepinephrine (NE) and serotonin, and that activation of NTR2 in the RVM produces antinociception mediated by spinal release of NE. Serotonin 146-155 neurotensin receptor 1 Homo sapiens 55-59 17965066-9 2008 However, BDNF exposure caused an enhancement of Ca(2+) transients induced by serotonin and substance P, which was reversed by the Trk receptor blocker K-252a (0.1 microM). Serotonin 77-86 Bdnf Cavia porcellus 9-13 18310457-1 2008 3,4-Dihydroxyphenylalanine decarboxylase (DDC; also known as l-amino acid decarboxylase) is involved in the synthesis of dopamine, norepinephrine, and serotonin, and also acts as an androgen receptor co-regulator protein. Serotonin 151-160 dopa decarboxylase Mus musculus 0-40 18310457-1 2008 3,4-Dihydroxyphenylalanine decarboxylase (DDC; also known as l-amino acid decarboxylase) is involved in the synthesis of dopamine, norepinephrine, and serotonin, and also acts as an androgen receptor co-regulator protein. Serotonin 151-160 dopa decarboxylase Mus musculus 42-45 17996031-3 2008 We previously showed that MA and MDMA increase corticosterone (CORT) and MDMA reduces levels of serotonin (5-HT) 24 h after treatment on P11, however, learning deficits are seen after 5 or 10 days of drug treatment, not just 1 day. Serotonin 96-105 S100 calcium binding protein A10 Rattus norvegicus 137-140 17919312-1 2008 The serotonin neurotransmitter system, including the 5-HT(3) receptor, has been implicated in the genesis of fatigue in patients with liver disease. Serotonin 4-13 5-hydroxytryptamine receptor 3A Rattus norvegicus 53-69 17924524-11 2008 These observations suggest that 5-HT1A receptors of the medial septum contribute to a serotonin-mediated mechanism involved in the encoding and consolidation, not the retrieval of spatial hippocampal-dependent knowledge. Serotonin 86-95 5-hydroxytryptamine receptor 1A Rattus norvegicus 32-38 18520162-6 2008 In this article, we review existing data on the effects of genetic variation in the dopamine and serotonin systems (catechol-O-methyltransferase, the serotonin-transporter-linked polymorphic region) on the morphometric, metabolic and functional characteristics of the cerebral cortex and limbic structures. Serotonin 97-106 catechol-O-methyltransferase Homo sapiens 116-144 17873333-1 2007 The serotonin (5HT) reuptake transporter (SERT) plays a key role in 5HT homeostasis by recycling 5HT into the presynaptic neurons. Serotonin 4-13 solute carrier family 6 member 4 Macaca mulatta 42-46 17873333-1 2007 The serotonin (5HT) reuptake transporter (SERT) plays a key role in 5HT homeostasis by recycling 5HT into the presynaptic neurons. Serotonin 15-18 solute carrier family 6 member 4 Macaca mulatta 42-46 17766642-1 2007 Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes. Serotonin 20-29 solute carrier family 18 member A2 Homo sapiens 126-159 17873333-1 2007 The serotonin (5HT) reuptake transporter (SERT) plays a key role in 5HT homeostasis by recycling 5HT into the presynaptic neurons. Serotonin 68-71 solute carrier family 6 member 4 Macaca mulatta 42-46 17873333-2 2007 Recently, polymorphisms in the length of the promoter region of the gene that encodes SERT have been linked to functional differences in reactivity to psychosocial stress, as the short (s) promoter length allele shows reduced transcriptionally activity in vitro and is associated with reduced 5HT activity and increased vulnerability to affective disorders. Serotonin 293-296 solute carrier family 6 member 4 Macaca mulatta 86-90 17873333-4 2007 In addition, since reduced 5HT activity may also predispose females to reproductive deficits, polymorphisms in the SERT gene may help explain individual differences in ovulatory function. Serotonin 27-30 solute carrier family 6 member 4 Macaca mulatta 115-119 17766642-1 2007 Monoamines, such as serotonin, dopamine, and norepinephrine, are sequestered into synaptic vesicles by specific transporters (vesicular monoamine transporter-2; VMAT2) using energy from an electrochemical proton gradient across the vesicle membranes. Serotonin 20-29 solute carrier family 18 member A2 Homo sapiens 161-166 18022203-7 2007 These data suggest that, at the concentrations employed, fluoxetine inhibits serotonin uptake at both DAT and SERT, whereas paroxetine only inhibits serotonin uptake at SERT. Serotonin 77-86 solute carrier family 6 member 3 Rattus norvegicus 102-105 18022203-8 2007 Thus, when DAT is inhibited by GBR 12909, kinetic parameters for serotonin uptake via SERT in striatum are not different from those obtained in hippocampus. Serotonin 65-74 solute carrier family 6 member 3 Rattus norvegicus 11-14 17211625-2 2007 In mammals, AADC is expressed in many tissues besides the nervous system, and is associated with additional regulatory roles of dopamine and serotonin in a wide range of tissues. Serotonin 141-150 dopa decarboxylase Mus musculus 12-16 17211625-6 2007 Double-label studies showed that AADC colocalized with serotonin, NCAM, PLCbeta2, and PGP9.5. Serotonin 55-64 dopa decarboxylase Mus musculus 33-37 19614678-6 2009 The effect of Abeta is mediated by G-protein coupled receptors, neuropeptide Y1 (NPY1R) and serotonin (5-hydroxytryptamine) receptor 2B, via phosphatidylinositol-3-OH kinase-dependent activation of the MAPK/ERK1/2. Serotonin 92-101 mitogen-activated protein kinase 3 Mus musculus 207-213 17673981-13 2007 CONCLUSIONS: Serotonin exerts both excitatory and inhibitory influences on motor impulsivity via 5-HT(2A) and 5-HT(2C) receptors in both rats and mice. Serotonin 13-22 5-hydroxytryptamine receptor 2A Rattus norvegicus 97-104 19614678-6 2009 The effect of Abeta is mediated by G-protein coupled receptors, neuropeptide Y1 (NPY1R) and serotonin (5-hydroxytryptamine) receptor 2B, via phosphatidylinositol-3-OH kinase-dependent activation of the MAPK/ERK1/2. Serotonin 103-122 mitogen-activated protein kinase 3 Mus musculus 207-213 19446603-0 2009 Serotonin-immunoreactive neurons in the postnatal MAO-A KO mouse lateral superior olive project to the inferior colliculus. Serotonin 0-9 monoamine oxidase A Mus musculus 50-55 17702902-6 2007 dose of the 5-hydroxytryptamine 1A (5-HT(1A)) antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide (WAY 100635) not only prevented MDMA-induced hypothermia, but resulted in the development of hyperthermia (mean temperature increase from baseline of 0.74 +/- 0.2 degrees C at 120 min). Serotonin 12-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 36-43 19652708-9 2009 The social-deficit phenotype in juvenile mice reared by Asic3(-/-) mice was associated with the reduced serotonin transmission of the brain. Serotonin 104-113 acid-sensing (proton-gated) ion channel 3 Mus musculus 56-61 19564617-3 2009 We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1. Serotonin 218-227 phospholipase C, beta 3 Mus musculus 318-326 17258709-8 2007 In the deafferented dorsal horn, noggin-FbAb treatment induced significant increases in the density of SP, calcitonin gene-related peptide (CGRP)- and 5-hydroxytryptamine (5-HT)-positive axons. Serotonin 151-170 noggin Homo sapiens 33-39 17620344-6 2007 The coexpression of both UGT1A1 and UGT1A4 increased the V(max) values of UGT1A6-catalyzed serotonin and diclofenac O-glucuronide formation. Serotonin 91-100 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 74-80 17165097-7 2007 PrP(c) was expressed in serotonin producing cells. Serotonin 24-33 prion protein Mus musculus 0-6 19302089-1 2009 BACKGROUND: Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 61-70 aldehyde dehydrogenase 2 family member Homo sapiens 125-153 19302089-1 2009 BACKGROUND: Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 61-70 aldehyde dehydrogenase 2 family member Homo sapiens 155-160 17895527-11 2007 Increases in both 5-HT(1A) receptor and SERT proteins may lead to decreased serotonin availability at synapses. Serotonin 76-85 5-hydroxytryptamine receptor 1A Rattus norvegicus 18-25 19159919-3 2009 It is thus conceivable that a modulation of synaptic dopamine (DA) levels induced by the inhibition of serotonin (5-HT) release, as a consequence of 5-HT(1A) agonists administration, might alleviate dyskinesias. Serotonin 103-112 5-hydroxytryptamine receptor 1A Rattus norvegicus 149-156 17335389-6 2007 COMT is involved in the catabolism of dopamine, and TPH is the rate-limiting enzyme for serotonin synthesis. Serotonin 88-97 catechol-O-methyltransferase Homo sapiens 0-4 17556652-9 2007 CONCLUSION: We conclude that increased contractions to serotonin in aorta from male mice are attributable to differences in RhoA/Rho-kinase activation in smooth muscle independent of differences in the expression of RhoA or Rho-kinase. Serotonin 55-64 ras homolog family member A Mus musculus 124-128 17699663-5 2007 At 12 months of age, methamphetamine-treated GDNF(+/-) mice exhibited less motor activity and lower levels of tyrosine hydroxylase-immunoreactivity, dopamine, DOPAC, and serotonin than wild-type mice. Serotonin 170-179 glial cell line derived neurotrophic factor Mus musculus 45-49 17287506-9 2007 Altogether, these results suggest that high levels of serotonin, acting through 5-HT2 receptors, have neuroprotective action on cortical neurons by controlling Bcl-X(L) mRNA levels and that this action is independent of trkB signaling. Serotonin 54-63 BCL2-like 1 Mus musculus 160-168 19308295-0 2009 Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Serotonin 13-22 mitogen-activated protein kinase 3 Mus musculus 145-186 19220502-1 2009 OBJECTIVE: To investigate the effect of serotonin depletion on phosphorylation and expression of NR1 subunit of N-methyl-D-aspartate (NMDA) receptor in trigeminal nucleus caudalis (TNC), and on trigeminal nociception evoked by dural inflammation. Serotonin 40-49 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 97-100 19220502-9 2009 RESULTS: Dural application of inflammatory soup led to the activation of trigeminal nociceptive system as well as the phosphorylation of NR1, which were further enhanced in the low serotonin condition. Serotonin 181-190 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 137-140 19220502-12 2009 CONCLUSIONS: Low serotonin condition facilitates dural inflammation-induced NR1 phosphorylation and trigeminal nociception. Serotonin 17-26 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 76-79 17663006-1 2007 The present study evaluated the effect of 5-hydroxytryptamine (5-HT) on intestinal Na(+)/H(+) exchanger (NHE) activity and the cellular signaling pathways involved in T84 cells. Serotonin 42-61 solute carrier family 9 member C1 Homo sapiens 105-108 19220502-13 2009 It is suggested that the mechanism of nociceptive facilitation in serotonin-depleted state may involve the increase in NR1 phosphorylation rather than the upregulation of NR1 subunit of NMDA receptor. Serotonin 66-75 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 119-122 19220502-13 2009 It is suggested that the mechanism of nociceptive facilitation in serotonin-depleted state may involve the increase in NR1 phosphorylation rather than the upregulation of NR1 subunit of NMDA receptor. Serotonin 66-75 glutamate ionotropic receptor NMDA type subunit 1 Rattus norvegicus 171-174 19445388-4 2009 Genetic knockout of the main enzyme in serotonin and catecholamines metabolism, MAO A, decreased the startle response and TST-induced hyperthermia but had no effect on TST-induced immobility in Tg8 mice indicating the differences in neurochemical regulation of these TST-induced responses. Serotonin 39-48 monoamine oxidase A Mus musculus 80-85 17113567-8 2007 Here we describe specific genetic interaction between tax-6 and kin-29 in regulating body size, serotonin mediated egg laying, and chemoreceptor expression. Serotonin 96-105 Serine/threonine-protein phosphatase 2B catalytic subunit Caenorhabditis elegans 54-59 17347341-2 2006 For example, a specific polymorphism ("short" allele) in the promoter region of the serotonin transporter (5-HTT) gene is associated with deficits in neurobehavioral functioning during infancy and in poor control of aggression and low serotonin metabolism throughout juvenile and adolescent development in monkeys who were reared with peers but not in monkeys who were reared with their mothers and peers during infancy. Serotonin 84-93 solute carrier family 6 member 4 Macaca mulatta 107-112 17347341-3 2006 In contrast, monkeys possessing the "long" allele of the 5-HTT gene exhibit normal neurobehavioral functioning, control of aggression, and serotonin metabolism regardless of their early social rearing history. Serotonin 139-148 solute carrier family 6 member 4 Macaca mulatta 57-62 17562393-1 2007 Expression of 5-hydroxytryptamine (5-HT) 2A receptor (5-HT2A) was studied in bullfrog and rat retinas by immunocytochemistry. Serotonin 14-33 5-hydroxytryptamine receptor 2A Rattus norvegicus 54-60 16990256-2 2006 In this study, stimulation of cultured smooth muscle cells with 5-hydroxytryptamine (5-HT) induced PAK1 phosphorylation at Thr-423 (an indication of p21-activated kinase (PAK) activation). Serotonin 64-83 p21 (RAC1) activated kinase 1 Homo sapiens 99-103 16917117-11 2006 Ang1 added to P-ECs from patients with iPAH increased the production of endothelin-1 (ET-1) and serotonin, but not of platelet-derived growth factor-BB or epidermal growth factor, and increased the amount of mRNA encoding tryptophan hydroxylase-1 (the rate-limiting enzyme of serotonin synthesis), preproET-1, and ET-1-converting enzyme. Serotonin 96-105 angiopoietin 1 Homo sapiens 0-4 16917117-11 2006 Ang1 added to P-ECs from patients with iPAH increased the production of endothelin-1 (ET-1) and serotonin, but not of platelet-derived growth factor-BB or epidermal growth factor, and increased the amount of mRNA encoding tryptophan hydroxylase-1 (the rate-limiting enzyme of serotonin synthesis), preproET-1, and ET-1-converting enzyme. Serotonin 276-285 angiopoietin 1 Homo sapiens 0-4 16616982-2 2006 The serotonin transporter (5-HTT) may play an important role in the termination of serotonergic neurotransmission by serotonin (5-HT) uptaking into presynaptic neurons and representing as an initial action site for selective 5-HTT reuptake inhibitors (SSRI). Serotonin 4-13 huntingtin Homo sapiens 29-32 16616982-2 2006 The serotonin transporter (5-HTT) may play an important role in the termination of serotonergic neurotransmission by serotonin (5-HT) uptaking into presynaptic neurons and representing as an initial action site for selective 5-HTT reuptake inhibitors (SSRI). Serotonin 4-13 huntingtin Homo sapiens 227-230 16714015-2 2006 Combining the selective alpha(2A)-adrenoceptor antagonist, BRL-44408 (10 mg/kg, s.c.), with fluoxetine (30 mg/kg, s.c.) elevated the extracellular levels of serotonin (5-HT) and noradrenaline in the rat frontal cortex, an effect not observed following antidepressant treatment alone. Serotonin 157-166 adrenoceptor alpha 2A Rattus norvegicus 24-46 16470720-0 2006 Cell-type-specific limitation on in vivo serotonin storage following ectopic expression of the Drosophila serotonin transporter, dSERT. Serotonin 41-50 Serotonin transporter Drosophila melanogaster 129-134 16470720-3 2006 The Drosophila serotonin transporter (dSERT) is normally expressed exclusively in serotonin (5-HT) neurons in the CNS. Serotonin 15-24 Serotonin transporter Drosophila melanogaster 38-43 16566843-0 2006 Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin. Serotonin 121-130 purinergic receptor P2X, ligand-gated ion channel, 1 Mus musculus 14-17 16332411-0 2006 Inhibitory effect of 5-hydroxytryptamine on hyperphagia in mice with genetic overexpression of neuropeptide Y. Serotonin 21-40 neuropeptide Y Mus musculus 95-109 16424145-4 2006 In the second, neuro-behavioral, part of the study we measured the brain content of 5-hydroxytryptamine (5-HT) as well as plasma amino acid profiles in well-trained exercising rats to test a hypothesis that BCAA may alleviate central aspects of fatigue. Serotonin 84-103 AT-rich interaction domain 4B Rattus norvegicus 207-211 16918427-8 2006 From animal studies there is robust evidence that lithium augmentation increases serotonin (5-HT) neurotransmission, possibly through a synergistic action of lithium and the antidepressant on brain 5-HT pathways. Serotonin 81-90 POU class 6 homeobox 1 Homo sapiens 192-199 16005635-1 2005 Long-term potentiation in sympathetic ganglia (gLTP) is an activity-dependent unique form of synaptic plasticity in that it is serotonin-dependent and can be completely inhibited by 5-HT3 receptor antagonists. Serotonin 127-136 5-hydroxytryptamine receptor 3A Rattus norvegicus 182-196 16005519-1 2005 Over the past decade, there has been increasing interest in the role of serotonin 6 (5-HT6) receptors in higher cognitive processes such as memory. Serotonin 72-81 5-hydroxytryptamine receptor 6 Homo sapiens 85-90 19033154-0 2009 Drosophila vesicular monoamine transporter mutants can adapt to reduced or eliminated vesicular stores of dopamine and serotonin. Serotonin 119-128 Vesicular monoamine transporter Drosophila melanogaster 0-42 19033154-2 2009 To investigate these adaptive processes, we have characterized mutations in the Drosophila vesicular monoamine transporter (dVMAT), which is required for the vesicular storage of dopamine, serotonin, and octopamine. Serotonin 189-198 Vesicular monoamine transporter Drosophila melanogaster 80-122 19033154-2 2009 To investigate these adaptive processes, we have characterized mutations in the Drosophila vesicular monoamine transporter (dVMAT), which is required for the vesicular storage of dopamine, serotonin, and octopamine. Serotonin 189-198 Vesicular monoamine transporter Drosophila melanogaster 124-129 19025979-1 2009 Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates bidirectional, sodium-independent transport of dopamine, norepinephrine, epinephrine, serotonin, and histamine. Serotonin 181-190 solute carrier family 22 member 3 Rattus norvegicus 0-28 19025979-1 2009 Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates bidirectional, sodium-independent transport of dopamine, norepinephrine, epinephrine, serotonin, and histamine. Serotonin 181-190 solute carrier family 22 member 3 Rattus norvegicus 30-34 18798253-2 2009 Serotonin can contribute to neuropathic pain after SCI, as suggested by our previous observation that transient blockade of the 5-HT(3) receptor by intrathecal injections of the antagonist ondansetron reduces mechanical allodynia after SCI in rats. Serotonin 0-9 5-hydroxytryptamine receptor 3A Rattus norvegicus 128-144 19016481-0 2009 An immunocapture/scintillation proximity analysis of G alpha q/11 activation by native serotonin (5-HT)2A receptors in rat cortex: blockade by clozapine and mirtazapine. Serotonin 87-96 G protein subunit alpha q Rattus norvegicus 53-62 18242725-4 2008 Since this issue of the journal is dedicated to serotonin (5HT) regulation of behavior, we will comment on the so far scanty, but significant, evidence for a role of 5HT in the regulation of CaMKII and MAPK. Serotonin 48-57 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 191-197 18242725-4 2008 Since this issue of the journal is dedicated to serotonin (5HT) regulation of behavior, we will comment on the so far scanty, but significant, evidence for a role of 5HT in the regulation of CaMKII and MAPK. Serotonin 166-169 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 191-197 18440664-1 2008 The serotonin (5-hydroxytryptamine, or 5-HT) transporters (5-HTT) are target-sites for commonly used antidepressants. Serotonin 4-13 huntingtin Homo sapiens 61-64 18440664-1 2008 The serotonin (5-hydroxytryptamine, or 5-HT) transporters (5-HTT) are target-sites for commonly used antidepressants. Serotonin 15-34 huntingtin Homo sapiens 61-64 19041748-0 2008 Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Serotonin 43-52 low density lipoprotein receptor-related protein 5 Mus musculus 0-4 19041748-3 2008 Instead, we show here that Lrp5 inhibits expression of Tph1, the rate-limiting biosynthetic enzyme for serotonin in enterochromaffin cells of the duodenum. Serotonin 103-112 low density lipoprotein receptor-related protein 5 Mus musculus 27-31 19041748-7 2008 By identifying duodenum-derived serotonin as a hormone inhibiting bone formation in an Lrp5-dependent manner, this study broadens our understanding of bone remodeling and suggests potential therapies to increase bone mass. Serotonin 32-41 low density lipoprotein receptor-related protein 5 Mus musculus 87-91 19041756-2 2008 We found that the induction of long-term facilitation (LTF) by repeated applications of serotonin, a modulatory transmitter released during learning in Aplysia, requires upregulation of kinesin heavy chain (KHC) in both pre- and postsynaptic neurons. Serotonin 88-97 kinesin family member 5B Homo sapiens 186-205 19041756-2 2008 We found that the induction of long-term facilitation (LTF) by repeated applications of serotonin, a modulatory transmitter released during learning in Aplysia, requires upregulation of kinesin heavy chain (KHC) in both pre- and postsynaptic neurons. Serotonin 88-97 kinesin family member 5B Homo sapiens 207-210 19036977-1 2008 RNA editing that converts adenosine to inosine replaces the gene-encoded Ile, Asn, and Ile (INI) of serotonin [5-hydroxytryptamine (5-HT)] receptor 2C (5-HT(2C)R) with Val, Gly, and Val (VGV). Serotonin 100-109 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 152-161 19036977-1 2008 RNA editing that converts adenosine to inosine replaces the gene-encoded Ile, Asn, and Ile (INI) of serotonin [5-hydroxytryptamine (5-HT)] receptor 2C (5-HT(2C)R) with Val, Gly, and Val (VGV). Serotonin 111-130 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 152-161 18949384-0 2008 Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells. Serotonin 52-61 high mobility group box 1 Homo sapiens 13-38 18949384-5 2008 Therefore, we examined whether serotonin (5-HT), a key factor involved in the development of atherosclerosis, induced HMGB1 release in human umbilical vein endothelial cells (HUVECs). Serotonin 31-40 high mobility group box 1 Homo sapiens 118-123 18597077-1 2008 RATIONALE: Antagonism at serotonin 5-HT2A and 5-HT2C receptors modulates cortical and striatal dopamine (DA) release and may underlie some aspects of the clinical efficacy of "atypical" antipsychotic compounds. Serotonin 25-34 5-hydroxytryptamine receptor 2A Rattus norvegicus 35-47 18652859-1 2008 Monoamine oxidases (MAOs) A and B are mitochondrial bound isoenzymes which catalyze the oxidative deamination of dietary amines and monoamine neurotransmitters, such as serotonin, norepinephrine, dopamine, beta-phenylethylamine and other trace amines. Serotonin 169-178 monoamine oxidase A Mus musculus 0-33 18695238-3 2008 Genetic deletion of serotonin in the brain was achieved by inactivating Lmx1b selectively in the raphe nuclei of the brainstem, resulting in a near-complete loss of 5-HT throughout the brain. Serotonin 20-29 LIM homeobox transcription factor 1 beta Mus musculus 72-77 18627905-2 2008 hCA III was efficiently activated by d-His, serotonin, pyridyl-alkylamines, and aminoethyl-piperazine/morpholine (K(A)s of 91nM-1.12microM), whereas the best hCA IV activators were 4-amino-phenylalanine, serotonin, and 4-(2-aminoethyl)-morpholine (K(A)s of 79nM-3.14microM). Serotonin 44-53 HCA1 Homo sapiens 0-3 18627905-2 2008 hCA III was efficiently activated by d-His, serotonin, pyridyl-alkylamines, and aminoethyl-piperazine/morpholine (K(A)s of 91nM-1.12microM), whereas the best hCA IV activators were 4-amino-phenylalanine, serotonin, and 4-(2-aminoethyl)-morpholine (K(A)s of 79nM-3.14microM). Serotonin 204-213 HCA1 Homo sapiens 0-3 18477467-0 2008 Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 70-76 18400843-10 2008 Serotonin itself is bound to Rac1 by TGase following 5-HT(2A) receptor stimulation as demonstrated by coimmunoprecipitation experiments and a dose-dependent decrease of serotonin-associated Rac1 by cystamine. Serotonin 169-178 transglutaminase 1 Homo sapiens 37-42 18400843-11 2008 These data support the hypothesis that Rac1 activity is transiently increased due to TGase-catalyzed transamidation of serotonin to Rac1 via stimulation of 5-HT(2A) receptors. Serotonin 119-128 transglutaminase 1 Homo sapiens 85-90 18267888-0 2008 Contractile effects of 5-hydroxytryptamine (5-HT) in the equine jejunum circular muscle: functional and immunohistochemical identification of a 5-HT1A-like receptor. Serotonin 23-42 5-hydroxytryptamine receptor 1A Equus caballus 144-150 18329096-12 2008 Therefore, developmental compensation by the NE and 5HT systems may contribute to the absence of a body weight phenotype in NPY deficient mice. Serotonin 52-55 neuropeptide Y Mus musculus 124-127 18446327-1 2008 RATIONALE: Serotonin in the dorsal periaqueductal gray (DPAG) through the activation of 5-HT(1A) and 5-HT(2A) receptors inhibits escape, a defensive behavior associated with panic attacks. Serotonin 11-20 5-hydroxytryptamine receptor 1A Rattus norvegicus 88-95 18446327-2 2008 Long-term treatment with antipanic drugs that nonselectively or selectively blocks the reuptake of serotonin (e.g., imipramine and fluoxetine, respectively) enhances the inhibitory effect on escape caused by intra-DPAG injection of 5-HT(1A) and 5-HT(2A) receptor agonists. Serotonin 99-108 5-hydroxytryptamine receptor 1A Rattus norvegicus 232-239 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Serotonin 128-137 aquaporin 10 Homo sapiens 44-56 18162482-5 2008 This conductance is modulated by norepinephrine, acting on alpha 1-adrenergic receptors, and serotonin, acting on 5-HT2 receptors. Serotonin 93-102 5-hydroxytryptamine receptor 2A Rattus norvegicus 114-119 17949546-5 2007 In this study we investigated the role of serotonin in colchicine-resistant FMF patients. Serotonin 42-51 MEFV innate immuity regulator, pyrin Homo sapiens 76-79 17949546-16 2007 Last but not least, serotonin may have a role in the pathogenesis of FMF. Serotonin 20-29 MEFV innate immuity regulator, pyrin Homo sapiens 69-72 17394137-0 2007 Serotonin 5-HT2A and 5-HT5A receptors are expressed by different motoneuron populations in rat Onuf"s nucleus. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 10-22 17850016-3 2007 The review provides converging line of evidence that: 1) brain serotonin contributes to critical mechanism underlying genetically defined individual differences in aggressiveness, and 2) genes encoding pivotal enzymes in serotonin metabolism (tryptophan hydroxylase, MAO A) and 5-HT(1A) receptors belong to a group of genes that modulate aggressive behaviour. Serotonin 63-72 monoamine oxidase A Mus musculus 267-272 17850016-3 2007 The review provides converging line of evidence that: 1) brain serotonin contributes to critical mechanism underlying genetically defined individual differences in aggressiveness, and 2) genes encoding pivotal enzymes in serotonin metabolism (tryptophan hydroxylase, MAO A) and 5-HT(1A) receptors belong to a group of genes that modulate aggressive behaviour. Serotonin 221-230 monoamine oxidase A Mus musculus 267-272 17452640-4 2007 Coexpression of nNOS with SERT in HEK293 cells decreased SERT cell surface localization and 5-hydroxytryptamine (5-HT) uptake. Serotonin 92-111 nitric oxide synthase 1 Homo sapiens 16-20 17498786-4 2007 Evidence suggests a role of 5-hydroxytryptamine (5-HT; serotonin)-1A receptors in the pathogenesis and treatment of TD because repeated administration of haloperidol resulted in an increase in the effectiveness of 5-HT-1A receptors while drugs with agonist activity at 5-HT-1A receptors could attenuate haloperidol-induced VCMs. Serotonin 28-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 214-221 17498786-4 2007 Evidence suggests a role of 5-hydroxytryptamine (5-HT; serotonin)-1A receptors in the pathogenesis and treatment of TD because repeated administration of haloperidol resulted in an increase in the effectiveness of 5-HT-1A receptors while drugs with agonist activity at 5-HT-1A receptors could attenuate haloperidol-induced VCMs. Serotonin 28-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 269-276 17454123-0 2007 The endogenous neurotransmitter, serotonin, modifies neuronal nitric oxide synthase activities. Serotonin 33-42 nitric oxide synthase 1 Homo sapiens 53-83 17454123-1 2007 Serotonin, an important neurotransmitter, is colocalized with neuronal nitric oxide synthase (nNOS), a homodimeric enzyme which catalyzes the production of nitric oxide (NO(.-)) and/or oxygen species. Serotonin 0-9 nitric oxide synthase 1 Homo sapiens 62-92 17454123-1 2007 Serotonin, an important neurotransmitter, is colocalized with neuronal nitric oxide synthase (nNOS), a homodimeric enzyme which catalyzes the production of nitric oxide (NO(.-)) and/or oxygen species. Serotonin 0-9 nitric oxide synthase 1 Homo sapiens 94-98 17454123-3 2007 Our results reveal that nNOS is activated by serotonin as both NADPH consumption and oxyhemoglobin (OxyHb) oxidation were enhanced. Serotonin 45-54 nitric oxide synthase 1 Homo sapiens 24-28 17454123-5 2007 But 5-hydroxytryptamine (5HT) induced the formation of both O and H(2)O(2) by nNOS, as evidenced by electron paramagnetic resonance (EPR) and by using specific spin traps. Serotonin 4-23 nitric oxide synthase 1 Homo sapiens 78-82 17454123-5 2007 But 5-hydroxytryptamine (5HT) induced the formation of both O and H(2)O(2) by nNOS, as evidenced by electron paramagnetic resonance (EPR) and by using specific spin traps. Serotonin 25-28 nitric oxide synthase 1 Homo sapiens 78-82 16300424-1 2005 Serotonin 5-HT2A receptor antagonists have been shown to attenuate the locomotor stimulant effects of cocaine in rats. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 10-16 17454123-6 2007 Overall, these results demonstrate that serotonin is able to activate nNOS, leading to the generation of reactive oxygen species (ROS) in addition to the NO(.-) production. Serotonin 40-49 nitric oxide synthase 1 Homo sapiens 70-74 17276041-0 2007 Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. Serotonin 15-34 histocompatibility minor 13 Homo sapiens 67-70 16150439-1 2005 The present study was performed to examine neuroprotective effects of 5-hydroxytryptamine (5-HT)(3) receptor antagonists against beta-amyloid protein (25--35)-, a synthetic 25--35 amyloid peptide, induced neurotoxicity using cultured rat cortical neurons. Serotonin 70-89 5-hydroxytryptamine receptor 3A Rattus norvegicus 91-108 17276041-0 2007 Interaction of 5-hydroxytryptamine (serotonin) against Aspergillus spp. Serotonin 36-45 histocompatibility minor 13 Homo sapiens 67-70 17301605-6 2007 RESULTS: In endothelial injury without antioxidant group (ED group, n=12), serotonin-induced left anterior descending coronary artery vasoconstriction was augmented from 7+/-4% (0 week) to 88+/-8% (8th week, P<0.01) with electrocardiogram-ST elevation, and an increase of cyclooxygenase-2 expression and a decrease of endothelial nitric oxide synthase expression was observed at the spasm portion removed from the endothelial denuded site. Serotonin 75-84 nitric oxide synthase 3 Sus scrofa 321-354 15826610-0 2005 Serotonin glucuronidation by Ah receptor- and oxidative stress-inducible human UDP-glucuronosyltransferase (UGT) 1A6 in Caco-2 cells. Serotonin 0-9 aryl hydrocarbon receptor Homo sapiens 29-40 17157402-3 2007 In addition, measurement of brain serotonin (5-HT) level using in vivo microdialysis showed that the brain 5-HT level in VPA-exposed rats was significantly higher than that in control rats. Serotonin 34-43 POU class 6 homeobox 1 Rattus norvegicus 101-108 15826610-0 2005 Serotonin glucuronidation by Ah receptor- and oxidative stress-inducible human UDP-glucuronosyltransferase (UGT) 1A6 in Caco-2 cells. Serotonin 0-9 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 79-116 15826610-2 2005 Recently, serotonin (5-hydroxytryptamine, 5-HT) has been characterized as a highly selective substrate of human UDP-glucuronosyltransferase UGT1A6 [Krishnaswamy S, Duan SX, von Moltke LL, Greenblatt DJ, Court MH. Serotonin 10-19 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 140-146 15826610-2 2005 Recently, serotonin (5-hydroxytryptamine, 5-HT) has been characterized as a highly selective substrate of human UDP-glucuronosyltransferase UGT1A6 [Krishnaswamy S, Duan SX, von Moltke LL, Greenblatt DJ, Court MH. Serotonin 21-40 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 140-146 15826610-3 2005 Validation of serotonin (5-hydroxytryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6. Serotonin 14-23 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 87-124 16679005-2 2007 5-HT(1A) autoreceptors are involved in the regulation of serotonin (5-HT) synthesis. Serotonin 57-66 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-7 15826610-3 2005 Validation of serotonin (5-hydroxytryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6. Serotonin 25-44 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 87-124 15695071-3 2005 Nicotine induced increase of dopamine and serotonin neurotransmission in limbic structures may alter the expression of VMAT2 in brains of smokers. Serotonin 42-51 solute carrier family 18 member A2 Homo sapiens 119-124 17101120-2 2006 We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) receptors as a result of increased synaptic availability of serotonin during a critical period of development. Serotonin 163-172 5-hydroxytryptamine receptor 1A Rattus norvegicus 78-85 15733655-6 2005 The results of these experiments provide anatomical and behavioral evidence that activation of NTR1-expressing spinally projecting neurons in the RVM produces antinociception through release of serotonin in the spinal dorsal horn. Serotonin 194-203 neurotensin receptor 1 Homo sapiens 95-99 15796067-0 2005 [Mechanisms of antidepressants and serotonin (5-HT)-induced glial cell line-derived neurotrophic factor (GDNF) releases in rat C6 gliobrastoma cells]. Serotonin 35-44 glial cell derived neurotrophic factor Rattus norvegicus 60-103 17027947-3 2006 The enzymatic properties of UGT1A6 proteins were characterized by the kinetic analysis of serotonin (5-hydroxytryptamine, 5-HT) and 4-methylumbelliferone (4-MU) glucuronidation. Serotonin 90-99 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 28-34 15796067-0 2005 [Mechanisms of antidepressants and serotonin (5-HT)-induced glial cell line-derived neurotrophic factor (GDNF) releases in rat C6 gliobrastoma cells]. Serotonin 35-44 glial cell derived neurotrophic factor Rattus norvegicus 105-109 15589524-7 2005 For the first time, 5-HT1A receptors are clearly proved to be involved in the progressive wind-up to 3-Hz frequency of electrical stimulation as well as after-discharges of sensory input of DH WDR neurons, and simultaneously recorded motor output of spinal reflexes to 20-Hz frequency of electrical stimulation; this suggests that serotonin, through 5-HT1A receptors, exerts an inhibitory role in the control of obstinate pathological pain. Serotonin 331-340 5-hydroxytryptamine receptor 1A Rattus norvegicus 20-26 17027947-3 2006 The enzymatic properties of UGT1A6 proteins were characterized by the kinetic analysis of serotonin (5-hydroxytryptamine, 5-HT) and 4-methylumbelliferone (4-MU) glucuronidation. Serotonin 101-120 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 28-34 16455786-11 2006 Forskolin, isoproterenol, and PACAP-38 stimulated serotonin secretion at EC50 values of 5 x 10(-10), 4.5 x 10(-10), and 1.2 x 10(-9) M, respectively. Serotonin 50-59 adenylate cyclase activating polypeptide 1 Homo sapiens 30-35 18085265-5 2008 In wild type (wt) and Ndn-/- neonates, immunohistofluorescence and biochemistry revealed that medullary 5HT neurons expressed Ndn in wt and that the medulla contained abnormally high levels of 5HT in Ndn-/-. Serotonin 104-107 necdin, MAGE family member Mus musculus 22-25 18085265-5 2008 In wild type (wt) and Ndn-/- neonates, immunohistofluorescence and biochemistry revealed that medullary 5HT neurons expressed Ndn in wt and that the medulla contained abnormally high levels of 5HT in Ndn-/-. Serotonin 104-107 necdin, MAGE family member Mus musculus 126-129 16257094-4 2006 The present study sought to evaluate the relationship between such behavioral endophenotypes in AD and genetic variations in dopamine- or serotonin-related genes, such as catechol-O-methyltransferase (COMT) or 5-HTT gene-linked promoter region (5-HTTLPR), and apolipoprotein E (APOE). Serotonin 138-147 catechol-O-methyltransferase Homo sapiens 171-199 18085265-5 2008 In wild type (wt) and Ndn-/- neonates, immunohistofluorescence and biochemistry revealed that medullary 5HT neurons expressed Ndn in wt and that the medulla contained abnormally high levels of 5HT in Ndn-/-. Serotonin 104-107 necdin, MAGE family member Mus musculus 126-129 16257094-4 2006 The present study sought to evaluate the relationship between such behavioral endophenotypes in AD and genetic variations in dopamine- or serotonin-related genes, such as catechol-O-methyltransferase (COMT) or 5-HTT gene-linked promoter region (5-HTTLPR), and apolipoprotein E (APOE). Serotonin 138-147 catechol-O-methyltransferase Homo sapiens 201-205 16251523-0 2005 Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). Serotonin 58-67 5-hydroxytryptamine receptor 1A Canis lupus familiaris 95-116 16251523-0 2005 Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). Serotonin 58-67 5-hydroxytryptamine receptor 1A Canis lupus familiaris 123-128 16452991-2 2006 We have demonstrated that activation of p38 mitogen-activated protein kinase (MAPK) induces a catalytic activation of the serotonin transporter (SERT) arising from a reduction in the SERT Km for 5-hydroxytryptamine (5-HT). Serotonin 195-214 mitogen activated protein kinase 14 Rattus norvegicus 40-76 16251523-0 2005 Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). Serotonin 58-67 solute carrier family 6 member 4 Canis lupus familiaris 199-205 18781940-4 2008 Herein, we review results described in the literature, starting from the year 2000, in the field of the fluorescent GPCR small, non-peptide ligands according to the affinity to the selected receptors (histamine, adenosine, adrenergic, cannabinoid, muscarinie, neuropeptide Y and serotonine) as well as the fluorophores that have been used to tag the molecules. Serotonin 279-289 G protein-coupled receptor 166 pseudogene Homo sapiens 116-120 16677721-15 2006 This may reflect a role for IL-6 in the tryptophan and serotonin responses to IL-1 and LPS. Serotonin 55-64 interleukin 1 complex Mus musculus 78-82 16157345-0 2006 Serotonin acts as an up-regulator of acyl-coenzyme A:cholesterol acyltransferase-1 in human monocyte-macrophages. Serotonin 0-9 sterol O-acyltransferase 1 Homo sapiens 37-82 18088278-3 2007 Treatment with the selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor fluoxetine increases P-Ser845-GluR1 but not P-Ser831-GluR1. Serotonin 29-38 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 116-121 18088278-3 2007 Treatment with the selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor fluoxetine increases P-Ser845-GluR1 but not P-Ser831-GluR1. Serotonin 40-59 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 116-121 18022203-0 2007 The promiscuity of the dopamine transporter: implications for the kinetic analysis of [3H]serotonin uptake in rat hippocampal and striatal synaptosomes. Serotonin 90-99 solute carrier family 6 member 3 Rattus norvegicus 23-43 18022203-2 2007 For example, serotonin is transported by the dopamine transporter (DAT) under conditions in which serotonin transporter (SERT) activity is eliminated (e.g., pharmacological inhibition). Serotonin 13-22 solute carrier family 6 member 3 Rattus norvegicus 45-65 16084651-4 2005 Indeed, systemic as well as local administrations of the serotonin agonist quipazine in the region of the suprachiasmatic nucleus mimic the effects of light on the circadian system of rats, i.e. they induce phase-advances of the locomotor activity rhythm as well as c-FOS expression in the suprachiasmatic nucleus during late subjective night. Serotonin 57-66 steroid sulfatase Rattus norvegicus 263-267 15680692-0 2005 Blockade of stimulant-induced preprodynorphin mRNA expression in the striatal matrix by serotonin depletion. Serotonin 88-97 prodynorphin Rattus norvegicus 30-45 18022203-2 2007 For example, serotonin is transported by the dopamine transporter (DAT) under conditions in which serotonin transporter (SERT) activity is eliminated (e.g., pharmacological inhibition). Serotonin 13-22 solute carrier family 6 member 3 Rattus norvegicus 67-70 16406667-0 2006 5-HT1A receptor activation counteracts c-Fos immunoreactivity induced in serotonin neurons of the raphe nuclei after immobilization stress in the male rat. Serotonin 73-82 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-6 17942267-7 2007 Furthermore, 5HT1A and NK1 receptors displayed very similar patterns of expression, which may support the hypothesis that potentiation of serotonin and substance P are involved in excitability regulating trigeminal motor functions, including mastication and breathing. Serotonin 138-147 5-hydroxytryptamine receptor 1A Rattus norvegicus 13-18 15730876-11 2005 The involved GABAergic neurons are hypothesized to be juxtaglomerular and granular cells, on which serotonin would act mainly via 5HT2C and via 5HT2A receptors respectively. Serotonin 99-108 5-hydroxytryptamine receptor 2A Rattus norvegicus 144-149 15730876-12 2005 The second subset of mitral cells (22.3%, n=54) were directly depolarized by serotonin acting through 5HT2A receptors. Serotonin 77-86 5-hydroxytryptamine receptor 2A Rattus norvegicus 102-107 16527989-0 2006 Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 94-100 15583118-13 2004 The magnitude of regional 5-HTT BP can provide a vulnerability to low levels of extracellular serotonin and symptoms of extremely negativistic dysfunctional attitudes. Serotonin 94-103 huntingtin Homo sapiens 28-31 16408260-8 2006 Colocalization between serotonin and SERT positive fibers was close to 100% in MAO inhibitor treated animals but only 30% in untreated rats. Serotonin 23-32 monoamine oxidase A Rattus norvegicus 79-82 15531082-3 2004 And 5-HT(6) receptor gene (HTR6) variants may be a genetic risk factor for late-onset Alzheimer"s disease (LOAD). Serotonin 4-8 5-hydroxytryptamine receptor 6 Homo sapiens 27-31 17879320-3 2007 Sax2 deficiency results in a decrease of fat and glycogen storage, reduced blood glucose levels, and raised serotonin levels in the hindbrain. Serotonin 108-117 NK1 homeobox 1 Homo sapiens 0-4 17620344-2 2007 The substrates specific for UGT1A1 (estradiol and bilirubin), UGT1A4 (imipramine and trifluoperazine), and UGT1A6 (serotonin and diclofenac) were used to determine the effects of the coexpression of the other UGT1A isoforms on the enzymatic activity. Serotonin 115-124 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 107-113 16497988-0 2006 Serotonin increases susceptibility to pulmonary hypertension in BMPR2-deficient mice. Serotonin 0-9 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 64-69 16959057-2 2007 Abnormalities in dopaminergic activity in the nigrostriatal system have been most often suggested to be involved because the agents which cause TD share in common potent antagonism of dopamine D2 receptors (DRD2), that notably is not balanced by effects such as more potent serotonin (5-HT)2A antagonism. Serotonin 274-283 dopamine receptor D2 Homo sapiens 207-211 16497988-5 2006 However, chronic infusion of serotonin caused increased pulmonary artery systolic pressure, right ventricular hypertrophy, and pulmonary artery remodeling in BMPR2(+/-) mice compared with wild-type littermates, an effect that was exaggerated under hypoxic conditions. Serotonin 29-38 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 158-163 16497988-6 2006 In addition, pulmonary, but not systemic, resistance arteries from BMPR2(+/-) mice exhibited increased contractile responses to serotonin mediated by both 5-HT2 and 5-HT1 receptors. Serotonin 128-137 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 67-72 16490344-1 2006 Monoamine oxidase (MAO) regulates levels of dopamine, serotonin, and noradrenaline in the nervous tissue and is required for proper neuronal development. Serotonin 54-63 monoamine oxidase A Rattus norvegicus 0-17 17868476-1 2007 BACKGROUND: Calcium (Ca2+) has recently been shown to selectively increase the activity of monoamine oxidase-A (MAO-A), a mitochondria-bound enzyme that generates peroxyradicals as a natural by-product of the deamination of neurotransmitters such as serotonin. Serotonin 250-259 monoamine oxidase A Mus musculus 91-110 17868476-1 2007 BACKGROUND: Calcium (Ca2+) has recently been shown to selectively increase the activity of monoamine oxidase-A (MAO-A), a mitochondria-bound enzyme that generates peroxyradicals as a natural by-product of the deamination of neurotransmitters such as serotonin. Serotonin 250-259 monoamine oxidase A Mus musculus 112-117 17876988-2 2007 Antidepressants enhance monoamine, such as serotonin, nor adrenaline and dopamine neurotransmission by blockade of monoamine transporter or monoamine oxydase. Serotonin 43-52 solute carrier family 18 member A2 Homo sapiens 115-136 17446559-5 2007 Serotonin also increased nonobese diabetic/severe combined immunodeficient repopulating cells in the expansion culture in terms of human CD45+, CD33+, CD14+ cells, BFU/CFU-E, and CFU-GEMM engraftment in BM of animals 6 weeks post-transplantation. Serotonin 0-9 CD14 molecule Homo sapiens 151-155 17944104-4 2007 5-HTT and COMT genes, regulating activity of serotonin and dopamine respectively, are related with accuracy of orientation in time. Serotonin 45-54 catechol-O-methyltransferase Homo sapiens 10-14 15496512-1 2004 GTP cyclohydrolase I (GCH) is the rate-controlling enzyme in the production of tetrahydrobiopterin (BH4) that is essential for the synthesis of nitric oxide and catecholamines including dopamine and serotonin. Serotonin 199-208 GTP cyclohydrolase 1 Homo sapiens 0-20 15496512-1 2004 GTP cyclohydrolase I (GCH) is the rate-controlling enzyme in the production of tetrahydrobiopterin (BH4) that is essential for the synthesis of nitric oxide and catecholamines including dopamine and serotonin. Serotonin 199-208 GTP cyclohydrolase 1 Homo sapiens 22-25 15605121-2 2004 The bath application of serotonin (5-HT; 50 microM) or phenylbiguanide (PBA; 50 microM), a potent 5-HT3 receptor agonist, increased the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) or miniature EPSCs (mEPSCs) in 35 of 83 neurons (42%). Serotonin 24-33 5-hydroxytryptamine receptor 3A Rattus norvegicus 98-112 15605121-2 2004 The bath application of serotonin (5-HT; 50 microM) or phenylbiguanide (PBA; 50 microM), a potent 5-HT3 receptor agonist, increased the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) or miniature EPSCs (mEPSCs) in 35 of 83 neurons (42%). Serotonin 35-39 5-hydroxytryptamine receptor 3A Rattus norvegicus 98-112 16490344-1 2006 Monoamine oxidase (MAO) regulates levels of dopamine, serotonin, and noradrenaline in the nervous tissue and is required for proper neuronal development. Serotonin 54-63 monoamine oxidase A Rattus norvegicus 19-22 16498236-5 2006 The expression of serta in raphe and ventral posterior tuberculum overlapped with the location of serotonin and expression of tryptophan hydroxylase, which is a key enzyme for serotonin synthesis. Serotonin 98-107 solute carrier family 6 member 4a Danio rerio 18-23 15356199-5 2004 All mutant phenotypes are rescued by expression of an itpr(+) transgene in serotonin and dopamine neurons. Serotonin 75-84 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 54-58 17570217-0 2007 High mucosal serotonin availability in neonatal guinea pig ileum is associated with low serotonin transporter expression. Serotonin 13-22 sodium-dependent serotonin transporter Cavia porcellus 88-109 16498236-5 2006 The expression of serta in raphe and ventral posterior tuberculum overlapped with the location of serotonin and expression of tryptophan hydroxylase, which is a key enzyme for serotonin synthesis. Serotonin 176-185 solute carrier family 6 member 4a Danio rerio 18-23 14997275-2 2004 The effects of milnacipran, a selective inhibitor of the reuptake of serotonin and noradrenaline, on LGIC receptors have not yet been investigated on such ion-channel receptors. Serotonin 69-78 glycine receptor alpha 3 Homo sapiens 101-105 17318659-1 2007 To describe the serotonergic system in a tunicate larva, we cloned a gene encoding for tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin synthesis, in the ascidian Ciona intestinalis and studied its expression pattern during development. Serotonin 145-154 tryptophan hydroxylase Ciona intestinalis 87-109 16488409-1 2006 5-hydroxytryptamine (5-HT) syndrome is a dangerous condition of 5-HT excess that can occur in the case of co-administration of a monoamine oxidase (MAO) inhibitor and a serotonin reuptake inhibitor (SSRI). Serotonin 2-19 monoamine oxidase A Rattus norvegicus 129-146 17318659-1 2007 To describe the serotonergic system in a tunicate larva, we cloned a gene encoding for tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin synthesis, in the ascidian Ciona intestinalis and studied its expression pattern during development. Serotonin 145-154 tryptophan hydroxylase Ciona intestinalis 111-114 15341267-5 2004 The conclusion was drawn that the 5-HT1A-receptors and enzymes of serotonin metabolism in the brain are involved in implementing genetic control of defensive behavior. Serotonin 66-75 5-hydroxytryptamine receptor 1A Rattus norvegicus 34-40 16488409-1 2006 5-hydroxytryptamine (5-HT) syndrome is a dangerous condition of 5-HT excess that can occur in the case of co-administration of a monoamine oxidase (MAO) inhibitor and a serotonin reuptake inhibitor (SSRI). Serotonin 2-19 monoamine oxidase A Rattus norvegicus 148-151 15341267-6 2004 Expression of the 5-HT1A-brain receptors was suggested to determine the levels of fear and anxiety and, consequently, the predisposition to defensive behavior, whereas the preferred strategy of defensive response (active or passive defensive) depends on genetically determined features of serotonin metabolism in the brain structures. Serotonin 289-298 5-hydroxytryptamine receptor 1A Rattus norvegicus 18-24 17184738-10 2007 Actions of CRF/Ucn 3 and EC cell-derived mediators, such as serotonin, might underlie several motor, secretory and/or sensory disorders of the gastrointestinal (GI) tract which may play a role in the pathophysiology of functional GI disorders, such as irritable bowel syndrome. Serotonin 60-69 urocortin 3 Homo sapiens 15-20 15034919-9 2004 The present findings thus demonstrate that ADAM is a specific SERT radioligand which can be used for in vivo study of central serotonin systems, and supports its use as a tracer for SPECT studies in human disorders involving dysfunction of serotonergic neurotransmission. Serotonin 126-135 ADAM metallopeptidase domain 7 Rattus norvegicus 43-47 16210420-12 2006 Serotonin (5-HT) concentration decreased significantly in the PVN after both intraperitoneal and intracerebroventricular injections of leptin and decreased in the VMH only with intracerebroventricular treatment of leptin. Serotonin 0-9 leptin Rattus norvegicus 135-141 17159160-1 2007 We previously demonstrated colocalization of serotonin 1A (5-HT(1A)) and serotonin 2A (5-HT(2A)) receptors in oxytocin and corticotropin-releasing factor neurons in the hypothalamic paraventricular nucleus (PVN). Serotonin 45-54 5-hydroxytryptamine receptor 1A Rattus norvegicus 59-66 17556795-1 2007 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-hydroxytryptamine 1A (serotonin; 5-HT1A) agonist was used to evaluate the role of somatodendritic and/or postsynaptic 5-HT1A receptors following exposure to restraint stress. Serotonin 88-97 5-hydroxytryptamine receptor 1A Rattus norvegicus 99-105 16210420-12 2006 Serotonin (5-HT) concentration decreased significantly in the PVN after both intraperitoneal and intracerebroventricular injections of leptin and decreased in the VMH only with intracerebroventricular treatment of leptin. Serotonin 0-9 leptin Rattus norvegicus 214-220 16428931-4 2006 In addition, activation of the Ras/Raf pathway led to a significant reduction in NE markers such as serotonin, chromogranin A and calcitonin. Serotonin 100-109 zinc fingers and homeoboxes 2 Homo sapiens 35-38 17461023-0 2007 [Antinociceptive properties of the 5-HT3 receptor antagonist in the model of inflammatory pain in rats of different age with prenatal deficit of serotonine and under stress]. Serotonin 145-155 5-hydroxytryptamine receptor 3A Rattus norvegicus 35-49 14988048-0 2004 Serotonin increases glial cell line-derived neurotrophic factor release in rat C6 glioblastoma cells. Serotonin 0-9 glial cell derived neurotrophic factor Rattus norvegicus 20-63 14988048-3 2004 We found that serotonin (5-HT) specifically increased GDNF mRNA expression and GDNF release in a dose- and time-dependent manner. Serotonin 14-23 glial cell derived neurotrophic factor Rattus norvegicus 54-58 14988048-3 2004 We found that serotonin (5-HT) specifically increased GDNF mRNA expression and GDNF release in a dose- and time-dependent manner. Serotonin 14-23 glial cell derived neurotrophic factor Rattus norvegicus 79-83 16483891-3 2006 Testosterone is necessary, but not sufficient, for evoking the persistent aggression, and that serotonin (5-HT) metabolism is altered in male nNOS-1-/- mice. Serotonin 95-104 nitric oxide synthase 1, neuronal Mus musculus 142-146 15020420-10 2004 However, this function does not require synaptic activity, suggesting that InsP(3)-mediated Ca(2+) release regulates the neurohormonal action of serotonin. Serotonin 145-154 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 75-81 17441000-1 2007 Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression. Serotonin 37-46 monoamine oxidase A Mus musculus 0-19 17441000-1 2007 Monoamine oxidase A (MAO A) degrades serotonin, dopamine and noradrenaline, factors critically involved in the regulation of aggression. Serotonin 37-46 monoamine oxidase A Mus musculus 21-26 16483891-9 2006 Because of reduced serotonin turnover, the excessive aggressiveness displayed by nNOS-1-/- mice may be symptomatic of a depressive-like syndrome. Serotonin 19-28 nitric oxide synthase 1, neuronal Mus musculus 81-85 16139430-1 2005 We recently showed that dopamine (DA) and serotonin (5-HT) exert anticonvulsant effects against limbic seizures in rats mediated by hippocampal D(2) and 5-HT(1A) receptor stimulation. Serotonin 42-51 5-hydroxytryptamine receptor 1A Rattus norvegicus 153-160 17064660-2 2006 Projections of serotonergic neurons onto POMC neurons suggest that leptin and serotonin converge onto POMC neurons to regulate body weight. Serotonin 78-87 pro-opiomelanocortin-alpha Mus musculus 41-45 14997015-1 2004 The effect of the selective serotonin uptake inhibitor fluoxetine was examined on prodynorphin gene expression. Serotonin 28-37 prodynorphin Rattus norvegicus 82-94 14997015-5 2004 Thus, chronic inhibition of serotonin uptake can regulate prodynorphin gene expression in the hypothalamus, caudate putamen, and nucleus accumbens. Serotonin 28-37 prodynorphin Rattus norvegicus 58-70 16326835-1 2005 Vesicular monoamine transporter 1 (VMAT1) is an integral protein in the membrane of secretory vesicles of neuroendocrine and endocrine cells that allows the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. Serotonin 199-208 solute carrier family 18 member A1 Homo sapiens 0-33 14581168-1 2003 The contaminants in deionized and distilled water (DDI water) boiled with polystyrene resin inhibited A-type monoamine oxidase (MAO, MAO-A preferentially deaminates serotonin and norepinephrine and regulates these amines concentration) activity in monkey brain mitochondria. Serotonin 165-174 monoamine oxidase A Rattus norvegicus 133-138 14581168-7 2003 These results indicate that zinc benzoate, which inhibits MAO-A activity, is easily incorporated in DDI water by boiling polystyrene and also may be a contaminating environmental chemical compound that alters the levels of serotonin and norepinephrine in the central nervous system. Serotonin 223-232 monoamine oxidase A Rattus norvegicus 58-63 16996750-1 2006 Immuno-electron microscopic and beta-microprobe studies have demonstrated that the internalization of serotonin 5-HT(1A) autoreceptors, after acute treatment with the selective 5-HT(1A) receptor agonist 8-OH-DPAT or with the specific serotonin reuptake inhibitor (SSRI) fluoxetine, is associated with a marked decrease in the in vivo binding of [(18)F]MPPF in the nucleus raphe dorsalis (NRD) of rat. Serotonin 102-111 5-hydroxytryptamine receptor 1A Rattus norvegicus 112-119 16996750-1 2006 Immuno-electron microscopic and beta-microprobe studies have demonstrated that the internalization of serotonin 5-HT(1A) autoreceptors, after acute treatment with the selective 5-HT(1A) receptor agonist 8-OH-DPAT or with the specific serotonin reuptake inhibitor (SSRI) fluoxetine, is associated with a marked decrease in the in vivo binding of [(18)F]MPPF in the nucleus raphe dorsalis (NRD) of rat. Serotonin 102-111 5-hydroxytryptamine receptor 1A Rattus norvegicus 177-184 17034589-5 2006 In the presence of serotonin, monocytes differentiated into DC with reduced expression of co-stimulatory molecules and CD1a, whereas expression of CD14 was increased. Serotonin 19-28 CD1a molecule Homo sapiens 119-123 17034589-5 2006 In the presence of serotonin, monocytes differentiated into DC with reduced expression of co-stimulatory molecules and CD1a, whereas expression of CD14 was increased. Serotonin 19-28 CD14 molecule Homo sapiens 147-151 16326835-1 2005 Vesicular monoamine transporter 1 (VMAT1) is an integral protein in the membrane of secretory vesicles of neuroendocrine and endocrine cells that allows the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. Serotonin 199-208 solute carrier family 18 member A1 Homo sapiens 35-40 14578450-3 2003 We now show that treatment with serotonin (5-HT) that produces long-term facilitation induces the Aplysia eukaryotic translation elongation factor 1alpha (Ap-eEF1A) as a late gene that might serve this coupling function in sensory neurons. Serotonin 32-41 eukaryotic translation elongation factor 1 alpha 1 Homo sapiens 158-163 16778797-6 2006 Our results identified indeed a functioning GFRP/GTPCHI axis in epidermal keratinocytes and melanocytes in the cytosol, adding the missing link for 6BH4 de novo synthesis which in turn controls cofactor supply for catecholamine and serotonin biosynthesis as well as melanogenesis in the human epidermis. Serotonin 232-241 GTP cyclohydrolase I feedback regulator Homo sapiens 44-48 16326835-10 2005 Furthermore, while VMAT1 can take up serotonin, VMAT1Delta15 cannot, indicating different functions for the two forms of VMAT1. Serotonin 37-46 solute carrier family 18 member A1 Homo sapiens 19-24 17031069-8 2006 This effect was also reversed by intracerebroventricular or intrathecal tropisetron, a 5-hydroxytryptamine(3) (5-HT(3))-receptor antagonist, and intraperitoneal bicuculline, a gamma-aminobutyric acid(A) (GABA(A))-receptor antagonist. Serotonin 87-106 5-hydroxytryptamine receptor 3A Rattus norvegicus 111-128 16281027-7 2005 Serotonin functions through MOD-1, a serotonin-gated chloride channel expressed in sensory interneurons, to promote aversive learning. Serotonin 0-9 Uncharacterized protein Caenorhabditis elegans 28-33 16963562-3 2006 Using an extracellular fusion protein that sequesters secreted TrkB ligands, we show that TrkB function is required for serotonin-induced activation of extracellular signal-regulated kinase, tail nerve shock-induced LTF in the CNS, and tail shock-induced LTM but is not necessary for short-term synaptic facilitation or short-term memory. Serotonin 120-129 neurotrophic receptor tyrosine kinase 2 Homo sapiens 63-67 15944205-6 2005 Six tryptophan metabolites, including the bioactive substances KYNA, XA, and the serotonin metabolite 5-hydroxyindol acetate inhibited [(3)H]p-aminohippurate (PAH) or 6-carboxyfluorescein (6-CF) uptake by 50-85%, demonstrating that these compounds interact with OAT1 as well as with OAT3. Serotonin 81-90 solute carrier family 22 (organic anion transporter), member 6 Mus musculus 262-266 16963562-3 2006 Using an extracellular fusion protein that sequesters secreted TrkB ligands, we show that TrkB function is required for serotonin-induced activation of extracellular signal-regulated kinase, tail nerve shock-induced LTF in the CNS, and tail shock-induced LTM but is not necessary for short-term synaptic facilitation or short-term memory. Serotonin 120-129 neurotrophic receptor tyrosine kinase 2 Homo sapiens 90-94 16856124-2 2006 The serotonin transporter (HTT) regulates the availability of serotonin by reuptake of the neurotransmitter from the synaptic cleft. Serotonin 4-13 huntingtin Homo sapiens 27-30 14612158-1 2003 The vesicular monoamine transporter-2 (VMAT-2) facilitates the sequestration of catecholamines and serotonin into synaptic vesicles, and is therefore an essential regulator of monoaminergic neuronal function. Serotonin 99-108 solute carrier family 18 member A2 Homo sapiens 4-37 14612158-1 2003 The vesicular monoamine transporter-2 (VMAT-2) facilitates the sequestration of catecholamines and serotonin into synaptic vesicles, and is therefore an essential regulator of monoaminergic neuronal function. Serotonin 99-108 solute carrier family 18 member A2 Homo sapiens 39-45 16247020-5 2005 Consistent with this structural change by cofilin overexpression, the synaptic strength was reduced, and furthermore, the long-term facilitation elicited by repeated pulses of 5-hydroxytryptamine was impaired in sensory-to-motor synapses. Serotonin 176-195 cofilin 1 Homo sapiens 42-49 14512515-0 2003 Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Serotonin 62-71 angiopoietin 1 Homo sapiens 42-56 14512515-0 2003 Induction of pulmonary hypertension by an angiopoietin 1/TIE2/serotonin pathway. Serotonin 62-71 TEK receptor tyrosine kinase Homo sapiens 57-61 14512515-6 2003 We demonstrate that Ang-1 stimulates pulmonary arteriolar endothelial cells through a TIE2 (receptor with tyrosine kinase activity containing IgG-like loops and epidermal growth factor homology domains) pathway to produce and secrete serotonin (5-hydroxytryptamine), a potent smooth muscle mitogen, and find that high levels of serotonin are present both in human and rodent pulmonary hypertensive lung tissue. Serotonin 234-243 angiopoietin 1 Homo sapiens 20-25 14512515-6 2003 We demonstrate that Ang-1 stimulates pulmonary arteriolar endothelial cells through a TIE2 (receptor with tyrosine kinase activity containing IgG-like loops and epidermal growth factor homology domains) pathway to produce and secrete serotonin (5-hydroxytryptamine), a potent smooth muscle mitogen, and find that high levels of serotonin are present both in human and rodent pulmonary hypertensive lung tissue. Serotonin 234-243 TEK receptor tyrosine kinase Homo sapiens 86-90 16414028-8 2006 High concentrations of 5-HTT-positive fibers in the central nucleus indicate that tight regulation of serotonin is critical in modulating fear responses mediated by this nucleus. Serotonin 102-111 huntingtin Homo sapiens 25-28 16414028-9 2006 High concentrations of 5-HTT-labeled fibers in the intercalated islands and parvicellular basal nucleus/paralaminar nucleus, which contain immature -appearing neurons, suggest a potential trophic role for serotonin in these subregions. Serotonin 205-214 huntingtin Homo sapiens 25-28 17081078-3 2006 Several putative molecular targets for treating cognition in schizophrenia show promise, such as treatments that act on the D(1) receptor of the dopamine system; the 5HT(1A), 5HT(2A), and 5HT(6), receptors of the serotonin system; and ampakines, Glycine/D-cycloserine, D-serine, and mGluR 2/3 agonists of the glutamatergic system. Serotonin 213-222 glutamate receptor, ionotropic, AMPA2 (alpha 2) Mus musculus 283-290 14512515-6 2003 We demonstrate that Ang-1 stimulates pulmonary arteriolar endothelial cells through a TIE2 (receptor with tyrosine kinase activity containing IgG-like loops and epidermal growth factor homology domains) pathway to produce and secrete serotonin (5-hydroxytryptamine), a potent smooth muscle mitogen, and find that high levels of serotonin are present both in human and rodent pulmonary hypertensive lung tissue. Serotonin 245-264 angiopoietin 1 Homo sapiens 20-25 15958718-2 2005 Using the model of the isolated rat tail artery, we show that the vasoactive mediator 5-hydroxytryptamine (5-HT), via the 5-HT2A metabotropic receptor, regulates the desensitization kinetics of P2X1 responses by increasing their rate of recovery. Serotonin 86-105 purinergic receptor P2X 1 Rattus norvegicus 194-198 14512515-6 2003 We demonstrate that Ang-1 stimulates pulmonary arteriolar endothelial cells through a TIE2 (receptor with tyrosine kinase activity containing IgG-like loops and epidermal growth factor homology domains) pathway to produce and secrete serotonin (5-hydroxytryptamine), a potent smooth muscle mitogen, and find that high levels of serotonin are present both in human and rodent pulmonary hypertensive lung tissue. Serotonin 245-264 TEK receptor tyrosine kinase Homo sapiens 86-90 14512515-6 2003 We demonstrate that Ang-1 stimulates pulmonary arteriolar endothelial cells through a TIE2 (receptor with tyrosine kinase activity containing IgG-like loops and epidermal growth factor homology domains) pathway to produce and secrete serotonin (5-hydroxytryptamine), a potent smooth muscle mitogen, and find that high levels of serotonin are present both in human and rodent pulmonary hypertensive lung tissue. Serotonin 328-337 angiopoietin 1 Homo sapiens 20-25 14512515-6 2003 We demonstrate that Ang-1 stimulates pulmonary arteriolar endothelial cells through a TIE2 (receptor with tyrosine kinase activity containing IgG-like loops and epidermal growth factor homology domains) pathway to produce and secrete serotonin (5-hydroxytryptamine), a potent smooth muscle mitogen, and find that high levels of serotonin are present both in human and rodent pulmonary hypertensive lung tissue. Serotonin 328-337 TEK receptor tyrosine kinase Homo sapiens 86-90 14520117-2 2003 Catechol-O-methyltransferase and monoamine oxidase enzymes are important agents in the metabolic inactivation of these neurotransmitters (ie, dopamine, serotonin, and norepinephrine). Serotonin 152-161 catechol-O-methyltransferase Homo sapiens 0-28 16903785-8 2006 DAF-7 inhibits serotonin synthesis in ADF, suggesting that ADF serotonin is a convergence point for regulation of hyperoxia avoidance. Serotonin 15-24 Dauer larva development regulatory growth factor daf-7 Caenorhabditis elegans 0-5 16903785-8 2006 DAF-7 inhibits serotonin synthesis in ADF, suggesting that ADF serotonin is a convergence point for regulation of hyperoxia avoidance. Serotonin 63-72 Dauer larva development regulatory growth factor daf-7 Caenorhabditis elegans 0-5 16888199-7 2006 These results indicate that PACAP may regulate the biological release of peptides and serotonin from BON cells and that, like in solid tumors, PACAP could potentially stimulate the growth of BON cells. Serotonin 86-95 adenylate cyclase activating polypeptide 1 Homo sapiens 28-33 15849736-7 2005 Using in vitro transport assays, we show that DVMAT-A recognizes DA, 5HT, octopamine, tyramine, and histamine as substrates, and similar to mammalian VMAT homologs, is inhibited by the drug reserpine and the environmental toxins 2,2,4,5,6-pentachlorobiphenyl and heptachlor. Serotonin 69-72 Vesicular monoamine transporter Drosophila melanogaster 46-53 16624293-4 2006 Chronic antidepressant treatment for over 3 weeks with the serotonin selective reuptake inhibitor, fluoxetine, increased neurogenesis in the Ts65Dn to comparable levels seen in the euploid by augmenting both proliferation and survival of BrdU-labeled cells in the subgranular layer and granule cell layer of the hippocampus, respectively. Serotonin 59-68 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 141-147 15849736-7 2005 Using in vitro transport assays, we show that DVMAT-A recognizes DA, 5HT, octopamine, tyramine, and histamine as substrates, and similar to mammalian VMAT homologs, is inhibited by the drug reserpine and the environmental toxins 2,2,4,5,6-pentachlorobiphenyl and heptachlor. Serotonin 69-72 Vesicular monoamine transporter Drosophila melanogaster 47-51 14578574-9 2003 These results indicate that 5-HT1A is strongly involved in the lordosis-inhibiting circuit of the serotonin neurons. Serotonin 98-107 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-34 15849736-10 2005 Our data suggest that DVMAT-A functions as a vesicular transporter for DA, 5HT, and octopamine in vivo, and will provide a powerful invertebrate model for the study of transporter trafficking and regulation. Serotonin 75-78 Vesicular monoamine transporter Drosophila melanogaster 22-29 26626679-1 2006 An adiabatic conformational analysis of serotonin (5-hydroxytryptamine, 5-HT) using quantum chemistry led to six stable conformers that can be either +gauche (Gp), -gauche (Gm), and anti (At) depending upon the value taken by ethylamine side chain and 5-hydroxyl group dihedral angles phi1, phi2, and phi4, respectively. Serotonin 40-49 protein phosphatase 1 regulatory inhibitor subunit 14B Homo sapiens 285-289 15993442-0 2005 Serotonin 5-HT2A but not 5-HT2C receptor antagonism reduces hyperlocomotor activity induced in dopamine-depleted rats by striatal administration of the D1 agonist SKF 82958. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 10-16 16497988-7 2006 Furthermore, pulmonary artery smooth muscle cells from BMPR2(+/-) mice exhibited a heightened DNA synthesis and activation of extracellular signal-regulated kinase 1/2 in response to serotonin compared with wild-type cells. Serotonin 183-192 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 55-60 16497988-7 2006 Furthermore, pulmonary artery smooth muscle cells from BMPR2(+/-) mice exhibited a heightened DNA synthesis and activation of extracellular signal-regulated kinase 1/2 in response to serotonin compared with wild-type cells. Serotonin 183-192 mitogen-activated protein kinase 3 Mus musculus 126-167 16497988-9 2006 These findings provide the first evidence for an interaction between BMPR-II-mediated signaling and the serotonin pathway, perturbation of which may be critical to the pathogenesis of PAH. Serotonin 104-113 bone morphogenetic protein receptor, type II (serine/threonine kinase) Mus musculus 69-76 12835394-7 2003 zag-1 activity also downregulates expression of genes involved in either the synthesis or reuptake of serotonin, dopamine and GABA. Serotonin 102-111 Zinc finger E-box-binding homeobox protein zag-1 Caenorhabditis elegans 0-5 16002744-14 2005 The acute failing rat ventricle is, thus, dually regulated by serotonin through Gq-coupled 5-HT2A receptors and Gs-coupled 5-HT4 receptors. Serotonin 62-71 5-hydroxytryptamine receptor 2A Rattus norvegicus 91-97 12871570-8 2003 Inhibition of brain MAO-A and -B by TV3326 resulted in significant elevations of dopamine, noradrenaline and serotonin in the striatum and hippocampus. Serotonin 109-118 monoamine oxidase A Rattus norvegicus 20-25 16537434-4 2006 Initial studies of 5-hydroxytryptamine (5-HT)(2A) receptor signaling in fibroblasts obtained from RSK2 wild-type (+/+) and knockout (-/-) mice showed that 5-HT(2A) receptor-mediated phosphoinositide hydrolysis and both basal and 5-HT-stimulated extracellular signal-regulated kinase 1/2 phosphorylation are augmented in RSK2 knockout fibroblasts. Serotonin 19-38 mitogen-activated protein kinase 3 Mus musculus 245-284 15996552-2 2005 We show here that this entrainment mechanism is inhibited by serotonin, acting through the Drosophila serotonin receptor 1B (d5-HT1B). Serotonin 61-70 5-hydroxytryptamine (serotonin) receptor 1B Drosophila melanogaster 91-123 16487506-7 2006 These behavioral data indicate the functional significance of increased extracellular serotonin concentrations due to combined use of a MAO-A inhibitor with subchronic lithium. Serotonin 86-95 monoamine oxidase A Rattus norvegicus 136-141 16487506-9 2006 The present study suggests that lithium augmentation of the antidepressant effect of MAO inhibitors is mediated by additional increases in the extracellular serotonin concentrations induced by MAO-A inhibition and suggests that the anxiolytic action of MAO inhibitors may be enhanced by lithium. Serotonin 157-166 monoamine oxidase A Rattus norvegicus 85-88 16487506-9 2006 The present study suggests that lithium augmentation of the antidepressant effect of MAO inhibitors is mediated by additional increases in the extracellular serotonin concentrations induced by MAO-A inhibition and suggests that the anxiolytic action of MAO inhibitors may be enhanced by lithium. Serotonin 157-166 monoamine oxidase A Rattus norvegicus 193-198 16487506-9 2006 The present study suggests that lithium augmentation of the antidepressant effect of MAO inhibitors is mediated by additional increases in the extracellular serotonin concentrations induced by MAO-A inhibition and suggests that the anxiolytic action of MAO inhibitors may be enhanced by lithium. Serotonin 157-166 monoamine oxidase A Rattus norvegicus 193-196 12682077-10 2003 Next, serotonin treatment of 5-HT2C R/3T3 cells resulted in a dose-dependent reduction of receptor interaction with PDZ 10. Serotonin 6-15 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 29-35 12682077-12 2003 Alkaline phosphatase treatment reverses the effect of serotonin, indicating that agonist-induced phosphorylation at Ser458 resulted in a loss of MUPP1 association and also revealed a significant amount of basal phosphorylation of the receptor. Serotonin 54-63 multiple PDZ domain crumbs cell polarity complex component Mus musculus 145-150 15996552-2 2005 We show here that this entrainment mechanism is inhibited by serotonin, acting through the Drosophila serotonin receptor 1B (d5-HT1B). Serotonin 61-70 5-hydroxytryptamine (serotonin) receptor 1B Drosophila melanogaster 125-132 12677356-2 2003 However, it is not known precisely how serotonin (5-HT) modulates the medial prefrontal cortex (mPFC) to affect cognitive function and behaviour. Serotonin 39-48 complement factor properdin Mus musculus 96-100 16223945-1 2006 The intestinal peristaltic reflex induced by mucosal stimulation is mediated by mucosal release of serotonin (5-HT), which acts on 5-HT(4) receptors located on CGRP-containing afferent nerve terminals. Serotonin 99-108 calcitonin-related polypeptide alpha Rattus norvegicus 160-164 15996552-6 2005 These data identify a molecular connection between serotonin signaling and the central clock component TIM and suggest a homeostatic mechanism for the regulation of circadian photosensitivity in Drosophila. Serotonin 51-60 timeless Drosophila melanogaster 103-106 17447419-2 2006 ), an endogenous MAO inhibitor, significantly increased norepinephrine and 5-hydroxytryptamine concentrations in the rat brain and also significantly increased acetylcholine and dopamine (DA) levels in the rat striatum. Serotonin 75-94 monoamine oxidase A Rattus norvegicus 17-20 16053268-2 2005 Such type of behavioural syndrome is induced by 8-hydroxy-2- (di-n-propylamino) tetralin (8-OH-DPAT) by directly stimulating the central postsynaptic 5-hydroxytryptamine (5-HT, serotonin) receptors of the 5-HT1A type. Serotonin 150-169 5-hydroxytryptamine receptor 1A Rattus norvegicus 205-211 16112139-1 2005 The present study was performed to examine the neuroprotective effects of 5-hydroxytryptamine (5-HT)(3) receptor antagonists against hydrogen peroxide (H(2)O(2))-induced neurotoxicity using cultured rat cortical neurons. Serotonin 74-93 5-hydroxytryptamine receptor 3A Rattus norvegicus 95-112 12694941-1 2003 Genetic inactivation of monoamine oxidase-A (MAO-A) significantly elevates levels of serotonin (5-HT) during early development and causes a disruption in the compartmented organization of thalamocortical axon terminals in layer 4 of the somatosensory cortex. Serotonin 85-94 monoamine oxidase A Mus musculus 24-43 12694941-1 2003 Genetic inactivation of monoamine oxidase-A (MAO-A) significantly elevates levels of serotonin (5-HT) during early development and causes a disruption in the compartmented organization of thalamocortical axon terminals in layer 4 of the somatosensory cortex. Serotonin 85-94 monoamine oxidase A Mus musculus 45-50 16049570-0 2005 Responsiveness of 5-HT(1A) and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition. Serotonin 95-104 5-hydroxytryptamine receptor 1A Rattus norvegicus 18-25 15939084-14 2005 These findings demonstrate that the 5-HT1A receptor is positioned to mediate developmental effects of serotonin in the hippocampus. Serotonin 102-111 5-hydroxytryptamine receptor 1A Rattus norvegicus 36-42 12668045-0 2003 Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Serotonin 72-81 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-20 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 12-21 monoamine oxidase A Rattus norvegicus 152-171 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 12-21 monoamine oxidase A Rattus norvegicus 173-178 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 23-42 monoamine oxidase A Rattus norvegicus 152-171 16286591-1 2005 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]), released by activated platelets during cardiac ischemia, is metabolized by the mitochondrial enzyme monoamine oxidase A (MAO-A). Serotonin 23-42 monoamine oxidase A Rattus norvegicus 173-178 15944377-2 2005 Here we show that serotonin, by activating 5-HT(1A) receptors, inhibited NMDA receptor-mediated ionic and synaptic currents in PFC pyramidal neurons, and the NR2B subunit-containing NMDA receptor is the primary target of 5-HT(1A) receptors. Serotonin 18-27 glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens 158-162 12670312-6 2003 In the present study, using an in vitro brain slice model and quantitative in situ hybridization for per1 and per2, we have shown that serotonin induces per1 gene expression at late subjective night but not at early night. Serotonin 135-144 period circadian regulator 2 Rattus norvegicus 110-114 15827572-1 2005 [18F]MPPF is a selective serotonin-1A (5-HT1A) receptor antagonist and may be used to measure changes in the functional levels of serotonin (5-HT). Serotonin 25-34 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-45 15944377-7 2005 Together, these results suggest that serotonin suppresses NMDAR function through a mechanism dependent on microtubule/kinesin-based dendritic transport of NMDA receptors that is regulated by CaMKII and ERK signaling pathways. Serotonin 37-46 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 191-197 15761113-4 2005 Initial studies using different substrates (serotonin, 5-hydroxytryptophol, 4-nitrophenol, acetaminophen, and valproic acid) showed similar results with 2-fold higher glucuronidation by UGT1A6(*)2 (S7A/T181A/R184S) compared with UGT1A6(*)1 (reference), and intermediate activities for other variants. Serotonin 44-53 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 186-192 16042979-0 2005 Role of serotonin (5-HT) in the antidepressant-like properties of neuropeptide Y (NPY) in the mouse forced swim test. Serotonin 8-17 neuropeptide Y Mus musculus 66-80 16042979-0 2005 Role of serotonin (5-HT) in the antidepressant-like properties of neuropeptide Y (NPY) in the mouse forced swim test. Serotonin 8-17 neuropeptide Y Mus musculus 82-85 12589380-4 2003 an acute serotonin (5-HT) inhibition induced by the specific stimulation of 5-HT1A autoreceptors (8-OHDPAT 5-100 microg/kg), on naloxone-induced conditioned place aversion in morphine-dependent rats. Serotonin 9-18 5-hydroxytryptamine receptor 1A Rattus norvegicus 76-82 16042979-3 2005 The present study was undertaken to explore the possible contribution of endogenous serotonin (5-HT) systems in the behavioral effects elicited by NPY in this model. Serotonin 84-93 neuropeptide Y Mus musculus 147-150 15761113-5 2005 Enzyme kinetic analyses with the UGT1A6-specific substrate (serotonin) showed 50% lower K(m) values for all R184S variants and 2-fold higher V(max) values for both S7A/T181A variants compared with UGT1A6(*)1. Serotonin 60-69 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 33-39 15761113-5 2005 Enzyme kinetic analyses with the UGT1A6-specific substrate (serotonin) showed 50% lower K(m) values for all R184S variants and 2-fold higher V(max) values for both S7A/T181A variants compared with UGT1A6(*)1. Serotonin 60-69 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 197-203 12485962-0 2003 Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6. Serotonin 14-23 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 86-123 12485962-2 2003 In this study serotonin was evaluated for use as a probe substrate for human UGT1A6 using recombinant human UGTs and tissue microsomes. Serotonin 14-23 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 77-83 15761114-5 2005 A positive moderate-to-heavy alcohol use history (>14 drinks per week) was the only demographic factor examined that correlated with phenotype and was associated with 2-fold higher serotonin glucuronidation (p < 0.001), UGT1A6 protein content (p = 0.004), and UGT1A6 mRNA content (p = 0.025). Serotonin 184-193 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 226-232 12485962-3 2003 Of the 10 commercially available recombinant UGT isoforms, only UGT1A6 catalyzed serotonin glucuronidation. Serotonin 81-90 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 45-48 12485962-3 2003 Of the 10 commercially available recombinant UGT isoforms, only UGT1A6 catalyzed serotonin glucuronidation. Serotonin 81-90 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 64-70 12485962-4 2003 Serotonin-UGT activity at 40 mM serotonin concentration varied more than 40-fold among human livers (n = 54), ranging from 0.77 to 32.9 nmol/min/mg of protein with a median activity of 7.1 nmol/min/mg of protein. Serotonin 0-9 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 10-13 15761114-5 2005 A positive moderate-to-heavy alcohol use history (>14 drinks per week) was the only demographic factor examined that correlated with phenotype and was associated with 2-fold higher serotonin glucuronidation (p < 0.001), UGT1A6 protein content (p = 0.004), and UGT1A6 mRNA content (p = 0.025). Serotonin 184-193 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 266-272 15645223-2 2005 With respect to mood related disorders the interaction between ER-beta and the serotonin (5-HT) system is highly relevant. Serotonin 79-88 estrogen receptor 2 (beta) Mus musculus 63-70 12485962-4 2003 Serotonin-UGT activity at 40 mM serotonin concentration varied more than 40-fold among human livers (n = 54), ranging from 0.77 to 32.9 nmol/min/mg of protein with a median activity of 7.1 nmol/min/mg of protein. Serotonin 32-41 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 10-13 15703274-2 2005 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO A) is an important source of hydrogen peroxide in rat heart. Serotonin 32-41 monoamine oxidase A Rattus norvegicus 59-78 12485962-5 2003 Serotonin-UGT activity kinetics of representative human liver microsomes (n = 7) and pooled human kidney, intestinal and lung microsomes and recombinant human UGT1A6 typically followed one enzyme Michaelis-Menten kinetics. Serotonin 0-9 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 10-13 12485962-5 2003 Serotonin-UGT activity kinetics of representative human liver microsomes (n = 7) and pooled human kidney, intestinal and lung microsomes and recombinant human UGT1A6 typically followed one enzyme Michaelis-Menten kinetics. Serotonin 0-9 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 159-165 12485962-9 2003 A highly significant correlation was found between immunoreactive UGT1A6 protein content and serotonin-UGT activity measured at 4 mM serotonin concentration in human liver microsomes (R(s) = 0.769; P < 0.001) (n = 52). Serotonin 93-102 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 66-72 12485962-9 2003 A highly significant correlation was found between immunoreactive UGT1A6 protein content and serotonin-UGT activity measured at 4 mM serotonin concentration in human liver microsomes (R(s) = 0.769; P < 0.001) (n = 52). Serotonin 93-102 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 66-69 12485962-9 2003 A highly significant correlation was found between immunoreactive UGT1A6 protein content and serotonin-UGT activity measured at 4 mM serotonin concentration in human liver microsomes (R(s) = 0.769; P < 0.001) (n = 52). Serotonin 133-142 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 66-72 12485962-9 2003 A highly significant correlation was found between immunoreactive UGT1A6 protein content and serotonin-UGT activity measured at 4 mM serotonin concentration in human liver microsomes (R(s) = 0.769; P < 0.001) (n = 52). Serotonin 133-142 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 66-69 12485962-10 2003 In conclusion, these results indicate that serotonin is a highly selective in vitro probe substrate for human UGT1A6. Serotonin 43-52 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 110-116 15703274-2 2005 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO A) is an important source of hydrogen peroxide in rat heart. Serotonin 32-41 monoamine oxidase A Rattus norvegicus 80-85 12732243-5 2003 We examined whether serotonin (5HT) and noradrenaline (NA) have direct effects on glucocorticoid receptor and mineralocorticoid receptor expression in primary hippocampal neurones, and whether antidepressants also exert direct effects on target neurones. Serotonin 20-29 nuclear receptor subfamily 3 group C member 2 Homo sapiens 110-136 15703274-3 2005 In the present study, we investigated the potential role of hydrogen peroxide generated by MAO A in cardiomyocyte hypertrophy by serotonin. Serotonin 129-138 monoamine oxidase A Rattus norvegicus 91-96 12732243-6 2003 Exposure of hippocampal cells to 5HT for 4 days increased both glucocorticoid and mineralocorticoid receptor mRNA and protein expression. Serotonin 33-36 nuclear receptor subfamily 3 group C member 2 Homo sapiens 82-108 15703274-5 2005 Serotonin also increased intracellular hydrogen peroxide and oxidative stress production, measured respectively by DCF fluorescence intensity and GSH/GSSG ratio, and promoted ERK1/2 phosphorylation (P<0.001). Serotonin 0-9 mitogen activated protein kinase 3 Rattus norvegicus 175-181 15703274-9 2005 These data suggest that part of cardiac hypertrophic effect of serotonin requires hydrogen peroxide production by MAO A and ERK1/2 activation. Serotonin 63-72 monoamine oxidase A Rattus norvegicus 114-119 15703274-9 2005 These data suggest that part of cardiac hypertrophic effect of serotonin requires hydrogen peroxide production by MAO A and ERK1/2 activation. Serotonin 63-72 mitogen activated protein kinase 3 Rattus norvegicus 124-130 14516688-3 2002 In order to characterize the organization of serotonergic neurons in the zebrafish we cloned two cDNAs encoding distinct forms of tryptophan hydroxylase (Tph), the rate-limiting enzyme in serotonin synthesis. Serotonin 188-197 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a Danio rerio 130-152 14516688-3 2002 In order to characterize the organization of serotonergic neurons in the zebrafish we cloned two cDNAs encoding distinct forms of tryptophan hydroxylase (Tph), the rate-limiting enzyme in serotonin synthesis. Serotonin 188-197 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a Danio rerio 154-157 15825078-2 2005 However, the effects of serotonin on Na+ /H+ exchange (NHE) activity in the human intestine have not been investigated fully. Serotonin 24-33 solute carrier family 9 member C1 Homo sapiens 37-53 14516688-12 2002 The co-expression of tphD1, tphD2 and 5-HT in the zebrafish diencephalon appears in striking contrast to the situation in mammals, where diencephalic serotonin results from re-uptake rather than from local production. Serotonin 150-159 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a Danio rerio 21-26 15825078-2 2005 However, the effects of serotonin on Na+ /H+ exchange (NHE) activity in the human intestine have not been investigated fully. Serotonin 24-33 solute carrier family 9 member C1 Homo sapiens 55-58 15825078-3 2005 The present studies examined the acute effects of 5-hydroxytryptamine (5-HT) on NHE activity using Caco-2 cells as an in vitro model. Serotonin 50-69 solute carrier family 9 member C1 Homo sapiens 80-83 15652697-9 2005 These observations suggest that serotonin via 5-HT1A receptors may represent an important modulator of hippocampal transmission important for cognitive and emotional functions through actions on both GABAergic and cholinergic neurons of the rat septal complex. Serotonin 32-41 5-hydroxytryptamine receptor 1A Rattus norvegicus 46-52 12213812-7 2002 Furthermore, the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 blocked serotonin-dependent activation of p44/42 MAPK (pERK1/2), a downstream effector of PKC and also down-regulated MMP-13 protein expression. Serotonin 89-98 mitogen activated protein kinase 3 Rattus norvegicus 123-126 12213812-7 2002 Furthermore, the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 blocked serotonin-dependent activation of p44/42 MAPK (pERK1/2), a downstream effector of PKC and also down-regulated MMP-13 protein expression. Serotonin 89-98 mitogen activated protein kinase 3 Rattus norvegicus 130-134 12213812-9 2002 From these studies, serotonin, binding through the 5-HT(2A) receptor, initiates a signaling cascade whereby stimulation of PLC leads to the activation of PKC and subsequently the ERK1/2 pathway, which ultimately results in MMP-13 production. Serotonin 20-29 mitogen activated protein kinase 3 Rattus norvegicus 179-185 15452682-3 2005 Data indicated that increasing serotonin neurotransmission by co-administration of the selective serotonin reuptake inhibitor (SSRI) fluoxetine and the serotonin-1A receptor antagonist p-MPPI reversed reward deficits observed during drug withdrawal (Harrison et al. Serotonin 31-40 5-hydroxytryptamine receptor 1A Rattus norvegicus 152-173 15642619-0 2005 Lack of functional estrogen receptor beta influences anxiety behavior and serotonin content in female mice. Serotonin 74-83 estrogen receptor 2 (beta) Mus musculus 19-41 12388591-0 2002 Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). Serotonin 38-47 hypocretin Mus musculus 85-91 12388591-0 2002 Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). Serotonin 38-47 hypocretin Mus musculus 92-102 15976459-1 2005 Serotonin (5-HT) stimulates superoxide release, phosphorylation of p42/p44 mitogen-activated protein kinase (MAPK), and DNA synthesis in bovine pulmonary artery smooth muscle cells. Serotonin 0-9 erythrocyte membrane protein band 4.2 Bos taurus 67-70 12149253-4 2002 Inhibiting the catalytic activity of protein phosphatase 1 (PP1) also eliminated the effect of serotonin on AMPA currents. Serotonin 95-104 protein phosphatase 1 catalytic subunit gamma Mus musculus 37-58 12149253-4 2002 Inhibiting the catalytic activity of protein phosphatase 1 (PP1) also eliminated the effect of serotonin on AMPA currents. Serotonin 95-104 protein phosphatase 1 catalytic subunit gamma Mus musculus 60-63 12149253-6 2002 Application of serotonin or 5-HT(1A) agonists to PFC slices reduced CaMKII activity and the phosphorylation of AMPA receptor subunit GluR1 at the CaMKII site in a PP1-dependent manner. Serotonin 15-24 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 133-138 12149253-6 2002 Application of serotonin or 5-HT(1A) agonists to PFC slices reduced CaMKII activity and the phosphorylation of AMPA receptor subunit GluR1 at the CaMKII site in a PP1-dependent manner. Serotonin 15-24 protein phosphatase 1 catalytic subunit gamma Mus musculus 163-166 12149253-7 2002 We concluded that serotonin, by activating 5-HT(1A) receptors, suppress glutamatergic signaling through the inhibition of CaMKII, which is achieved by the inhibition of PKA and ensuing activation of PP1. Serotonin 18-27 protein phosphatase 1 catalytic subunit gamma Mus musculus 199-202 16165284-7 2005 These results suggest that the lateral hypothalamus modifies nociception in part by activating spinally projecting serotonin neurons that act at 5-HT1A, 5-HT1B, and 5-HT3 receptors in the dorsal horn. Serotonin 115-124 5-hydroxytryptamine receptor 1A Rattus norvegicus 145-151 12185404-1 2002 RATIONALE: In animal models of reduced dopamine transmission, such as haloperidol-induced catalepsy or monoamine-depleted animals, serotonin (5-hydroxytryptamine; 5-HT) 5-HT(1A) agonists appear to enhance motor activity. Serotonin 131-140 5-hydroxytryptamine receptor 1A Rattus norvegicus 169-176 12185404-1 2002 RATIONALE: In animal models of reduced dopamine transmission, such as haloperidol-induced catalepsy or monoamine-depleted animals, serotonin (5-hydroxytryptamine; 5-HT) 5-HT(1A) agonists appear to enhance motor activity. Serotonin 142-161 5-hydroxytryptamine receptor 1A Rattus norvegicus 169-176 16095048-1 2005 Bufotenine and N,N-dimethyltryptamine (DMT) are hallucinogenic dimethylated indolethylamines (DMIAs) formed from serotonin and tryptamine by the enzyme indolethylamine N-methyltransferase (INMT) ubiquitously present in non-neural tissues. Serotonin 113-122 indolethylamine N-methyltransferase Homo sapiens 152-187 12077173-8 2002 The P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2",5"-disulphonic acid (PPADS) (60 microm in the bath) abolished the APs evoked by ATP and ATP-gamma-S but spared similar responses evoked by 5-hydroxytryptamine (5-HT). Serotonin 200-219 ATPase phospholipid transporting 8A2 Homo sapiens 141-144 12077173-8 2002 The P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2",5"-disulphonic acid (PPADS) (60 microm in the bath) abolished the APs evoked by ATP and ATP-gamma-S but spared similar responses evoked by 5-hydroxytryptamine (5-HT). Serotonin 200-219 ATPase phospholipid transporting 8A2 Homo sapiens 149-152 16095048-1 2005 Bufotenine and N,N-dimethyltryptamine (DMT) are hallucinogenic dimethylated indolethylamines (DMIAs) formed from serotonin and tryptamine by the enzyme indolethylamine N-methyltransferase (INMT) ubiquitously present in non-neural tissues. Serotonin 113-122 indolethylamine N-methyltransferase Homo sapiens 189-193 12077173-8 2002 The P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2",5"-disulphonic acid (PPADS) (60 microm in the bath) abolished the APs evoked by ATP and ATP-gamma-S but spared similar responses evoked by 5-hydroxytryptamine (5-HT). Serotonin 221-225 ATPase phospholipid transporting 8A2 Homo sapiens 141-144 16095048-8 2005 This can be explained by rapid catabolism of the DMIAs by mitochondrial monoamino-oxidase or by the fact that the dimethylated products of serotonin and tryptamine are not formed in significant amounts in most mammalian tissues despite the widespread presence of INMT in tissues. Serotonin 139-148 indolethylamine N-methyltransferase Homo sapiens 263-267 12077173-8 2002 The P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2",5"-disulphonic acid (PPADS) (60 microm in the bath) abolished the APs evoked by ATP and ATP-gamma-S but spared similar responses evoked by 5-hydroxytryptamine (5-HT). Serotonin 221-225 ATPase phospholipid transporting 8A2 Homo sapiens 149-152 15448133-1 2004 GTP cyclohydrolase I (GTPCHI) is the rate-limiting enzyme involved in the biosynthesis of tetrahydrobiopterin, a key cofactor necessary for nitric oxide synthase and for the hydroxylases that are involved in the production of catecholamines and serotonin. Serotonin 245-254 GTP cyclohydrolase 1 Homo sapiens 0-20 11893438-0 2002 The influence of ciclosporine A on the vasoactive effects of serotonin in in vitro perfused human umbilical arteries. Serotonin 61-70 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 17-31 15448133-1 2004 GTP cyclohydrolase I (GTPCHI) is the rate-limiting enzyme involved in the biosynthesis of tetrahydrobiopterin, a key cofactor necessary for nitric oxide synthase and for the hydroxylases that are involved in the production of catecholamines and serotonin. Serotonin 245-254 GTP cyclohydrolase 1 Homo sapiens 22-28 11893438-2 2002 AIM: To investigate the influence of ciclosporine A (CsA) on the vasoactive effects of serotonin in human umbilical arteries. Serotonin 87-96 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 37-51 15166106-1 2004 Serotonin (5-hydroxytryptamine, 5-HT) controls pyramidal cell activity in prefrontal cortex (PFC) through various receptors, in particular, 5-HT1A and 5-HT2A receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 140-152 11872248-3 2002 It has been supposed that SERT and MAOA genes are involved in enhancement of serotonin inactivation in response to the increase of serotonergic activity shown earlier in the losers. Serotonin 77-86 monoamine oxidase A Mus musculus 35-39 11834493-1 2002 The recent development of mice doubly deficient for monoamine oxidase A and B (MAO-A/B, respectively) has raised questions about the impact of these mutations on cardiovascular function, in so far as these animals demonstrate increased tissue levels of the vasoactive amines serotonin, norepinephrine, dopamine, and phenylethylamine. Serotonin 275-284 monoamine oxidase A Mus musculus 52-77 15166106-1 2004 Serotonin (5-hydroxytryptamine, 5-HT) controls pyramidal cell activity in prefrontal cortex (PFC) through various receptors, in particular, 5-HT1A and 5-HT2A receptors. Serotonin 11-30 5-hydroxytryptamine receptor 1A Rattus norvegicus 140-152 15588759-1 2004 The mechanism by which stimulation of somatodendritic and/or postsynaptic 5-hydroxytryptamine (5-HT, serotonin)-1A receptor could attenuate acute Parkinsonian-like effects of typical antipsychotics is investigated by comparing the anticataleptic and neurochemical effects of 8-hydroxy-2-di-n-propylaminotetralin (8-OH-DPAT) and buspirone in rats injected with haloperidol. Serotonin 74-93 5-hydroxytryptamine receptor 1A Rattus norvegicus 101-123 15352136-0 2004 Serotonin-induced phase advances of SCN neuronal firing in vitro: a possible role for 5-HT5A receptors? Serotonin 0-9 5-hydroxytryptamine receptor 5A Rattus norvegicus 86-92 11911838-1 2002 Recent studies with rat tissue preparations have suggested that the anorectic drug phentermine inhibits serotonin degradation by inhibition of monoamine oxidase (MAO) A with a K(I) value of 85-88 microM, a potency suggested to be similar to that of other reversible MAO inhibitors (Ulus et al., Biochem Pharmacol 2000;59:1611-21). Serotonin 104-113 monoamine oxidase A Rattus norvegicus 143-160 11911838-1 2002 Recent studies with rat tissue preparations have suggested that the anorectic drug phentermine inhibits serotonin degradation by inhibition of monoamine oxidase (MAO) A with a K(I) value of 85-88 microM, a potency suggested to be similar to that of other reversible MAO inhibitors (Ulus et al., Biochem Pharmacol 2000;59:1611-21). Serotonin 104-113 monoamine oxidase A Rattus norvegicus 162-165 15151902-3 2004 5-Hydroxytryptamine (5-HT), [d-Ala(2), d-Leu(5)]-enkephalin (DADLE), and baclofen enhanced ISO-induced cAMP levels and CFTR currents in oocytes expressing beta(2)-adrenoceptor-CFTR and 5-HT(1A) receptor (5-HT(1A)R), delta-opioid receptor, or GABA(B) receptor, respectively. Serotonin 1-19 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Xenopus laevis 119-123 11880481-1 2002 Noradrenaline and serotonin are known to control arginine-vasopressin (AVP) and oxytocin (OT) secretion in the systemic circulation. Serotonin 18-27 arginine vasopressin Mus musculus 71-74 15151902-3 2004 5-Hydroxytryptamine (5-HT), [d-Ala(2), d-Leu(5)]-enkephalin (DADLE), and baclofen enhanced ISO-induced cAMP levels and CFTR currents in oocytes expressing beta(2)-adrenoceptor-CFTR and 5-HT(1A) receptor (5-HT(1A)R), delta-opioid receptor, or GABA(B) receptor, respectively. Serotonin 1-19 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) Xenopus laevis 176-180 11880481-3 2002 To test this hypothesis, we used the Tg8 transgenic mice KO for the monoamine oxidase-A gene, which present high levels of noradrenaline and serotonin in the brain. Serotonin 141-150 monoamine oxidase A Mus musculus 68-87 11880481-10 2002 Likewise, serotonin is proposed to stimulate AVP and OT expression in the PVN and only OT expression in the SON. Serotonin 10-19 arginine vasopressin Mus musculus 45-48 15138437-7 2004 The potentiation of SSRI-induced increases in hippocampal serotonin levels was reproduced by the 5-HT(2C) receptor-selective antagonists SB 242084 and RS 102221, but not by the 5-HT(2A) receptor-selective antagonist MDL 100 907. Serotonin 58-67 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 97-114 15258112-0 2004 Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Serotonin 55-64 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 113-144 11902118-0 2002 Effect of endogenous serotonin on the binding of the 5-hT1A PET ligand 18F-MPPF in the rat hippocampus: kinetic beta measurements combined with microdialysis. Serotonin 21-30 5-hydroxytryptamine receptor 1A Rattus norvegicus 53-59 11902118-1 2002 By using a combination of an original beta+-sensitive intracerebral probe and microdialysis, the effect of increased endogenous serotonin on specific binding of 18F-MPPF [4-(2"-methoxyphenyl)-1-[2"-[N-(2"-pyridinyl)-p-fluorobenzamido]ethyl]piperazine] to the serotonin-1A (5-HT1A) receptors was investigated in the hippocampus of the anaesthetized rat. Serotonin 128-137 5-hydroxytryptamine receptor 1A Rattus norvegicus 273-279 12043045-7 2002 TRH remains under a constant inhibition by serotonin and reduced intracerebral serotonin concentration seen in depression will lead to increased TRH concentration in brain tissue. Serotonin 79-88 thyrotropin releasing hormone Homo sapiens 145-148 15258112-0 2004 Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6. Serotonin 66-85 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 113-144 15078882-6 2004 We found that activation of Rap1B by selected doses of agonists able to elicit comparable intracellular Ca(2+) increase and serotonin release was differently dependent on secreted ADP. Serotonin 124-133 RAP1B, member of RAS oncogene family Homo sapiens 28-33 15051668-5 2004 5-hydroxytryptamine (5-HT) increased vascular contraction and phosphorylation of both MAPK isoforms; these were greater in DOCA-salt hypertensive rats than in sham-operated rats. Serotonin 0-19 mitogen activated protein kinase 3 Rattus norvegicus 86-90 12448787-1 2002 The effects of phorbol 12-myristate, 13-acetate (PMA) on 5-hydroxytryptamine (5-HT)-evoked ion currents in the mouse 5-HT3A receptor were examined. Serotonin 57-76 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 117-123 15743927-9 2005 These data indicate that 5-HT1A receptor stimulation in the PVN mediates the characteristic neuroendocrine response to serotonin agonist challenge. Serotonin 119-128 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-31 14615479-2 2004 We show here by gene targeting that ADAR1 selectively edits in vivo two of five closely spaced adenosines in the serotonin 5-hydroxytryptamine subtype 2C receptor pre-mRNA of nervous tissue; and hence, site-selective adenosine-to-inosine editing is indeed a function of ADAR1. Serotonin 113-122 adenosine deaminase, RNA-specific Mus musculus 36-41 15900225-1 2005 OBJECTIVES: Catechol-O-methyltransferase plays a central role in the metabolism of biogenic amines such as norepinephrine, dopamine and serotonin. Serotonin 136-145 catechol-O-methyltransferase Homo sapiens 12-40 15637072-0 2005 Involvement of c-Src and protein kinase C delta in the inhibition of Cl(-)/OH- exchange activity in Caco-2 cells by serotonin. Serotonin 116-125 protein kinase C delta Homo sapiens 25-47 11728384-1 2001 Serotonin (5-HT) synthesis rates were calculated on the basis of the assumption that trapping of alpha-[14C]methyl-L-tryptophan (alpha-[14C]MTrp) is directly related to brain 5-HT synthesis. Serotonin 0-9 POU class 6 homeobox 1 Rattus norvegicus 169-176 14615479-2 2004 We show here by gene targeting that ADAR1 selectively edits in vivo two of five closely spaced adenosines in the serotonin 5-hydroxytryptamine subtype 2C receptor pre-mRNA of nervous tissue; and hence, site-selective adenosine-to-inosine editing is indeed a function of ADAR1. Serotonin 113-122 adenosine deaminase, RNA-specific Mus musculus 270-275 11704258-0 2001 Cocaine and serotonin: a role for the 5-HT(1A) receptor site in the mediation of cocaine stimulant effects. Serotonin 12-21 5-hydroxytryptamine receptor 1A Rattus norvegicus 38-45 11750790-1 2001 The availability of mutant mice that lack either MAO A or MAO B has created unique profiles in the central and peripheral availability of serotonin, norepinephrine, dopamine, and phenylethylamine. Serotonin 138-147 monoamine oxidase A Mus musculus 49-54 15637072-4 2005 Our results demonstrate that serotonin inhibits Cl(-)/OH- exchange activity in Caco-2 cells via both tyrosine kinase and Ca(2+)-independent protein kinase C delta-mediated pathways involving either 5-HT3 or 5-HT4 receptor subtype. Serotonin 29-38 protein kinase C delta Homo sapiens 140-162 15663891-1 2005 AIM: To investigate the effects of orexin A on release of histamine, norepinephrine, and serotonin in the frontal cortex of mice. Serotonin 89-98 hypocretin Mus musculus 35-43 14717702-1 2004 GTP cyclohydrolase I (GCH) is the rate-limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin. Serotonin 212-221 GTP cyclohydrolase 1 Homo sapiens 0-20 15659601-3 2005 However, in the BALB/c strain, a genetically distinct inbred strain with lower forebrain serotonin levels, spontaneously elevated anxiety, and increased stress reactivity, the majority of 5-HT2C mRNA is nonedited and encodes receptors with the highest constitutive activity and the highest agonist affinity and potency. Serotonin 89-98 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 188-194 15664701-4 2005 Using dual-label immunocytochemistry for ER-alpha or ER-beta with tryptophan hydroxylase (TPH), the rate-limiting enzyme for 5-hydroxytryptamine (5-HT) synthesis, over 90% of ER-beta ir cells exhibited TPH-ir in all DRN subdivisions, whereas only 23% of ER-alpha ir cells contained TPH. Serotonin 125-144 estrogen receptor 2 (beta) Mus musculus 53-60 14717702-1 2004 GTP cyclohydrolase I (GCH) is the rate-limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin. Serotonin 212-221 GTP cyclohydrolase 1 Homo sapiens 22-25 16206879-4 2005 For example, serotonin (5-HT) metabolism is altered in male nNOS-/- mice. Serotonin 13-22 nitric oxide synthase 1, neuronal Mus musculus 60-64 11532342-1 2001 Co-application of SKF-38393 (dopamine D(1) agonist; 1 mg/kg) and DOI (serotonin(2) agonist; 1 mg/kg) induced a synergistic increase in striatal preprotachykinin (PPT) mRNA levels in adult rats 60 days after neonatal intracerebroventricular injection of 6-hydroxydopamine. Serotonin 70-79 tachykinin, precursor 1 Rattus norvegicus 144-160 11504692-1 2001 Our previous studies have shown that 5-hydroxytryptamine (5-HT) induces cellular hyperplasia/hypertrophy through protein tyrosine phosphorylation, rapid formation of superoxide (O(2)(-)), and extracellular signal-regulated kinase (ERK)1/ERK2 mitogen-activated protein (MAP) kinase activation. Serotonin 37-56 mitogen-activated protein kinase 3 Bos taurus 192-236 15541873-0 2004 Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala. Serotonin 119-128 urocortin 2 Homo sapiens 18-29 11504692-1 2001 Our previous studies have shown that 5-hydroxytryptamine (5-HT) induces cellular hyperplasia/hypertrophy through protein tyrosine phosphorylation, rapid formation of superoxide (O(2)(-)), and extracellular signal-regulated kinase (ERK)1/ERK2 mitogen-activated protein (MAP) kinase activation. Serotonin 58-62 mitogen-activated protein kinase 3 Bos taurus 192-236 14643167-7 2004 The results of this study suggest that ASM contributes to the uptake and metabolism of serotonin via SERT and MAO, respectively, and may therefore play a role in the inactivation of endogenous serotonin generated within the airway wall. Serotonin 87-96 sodium-dependent serotonin transporter Cavia porcellus 101-105 11522440-0 2001 Relationships of 5-hydroxytryptamine immunoreactive terminal-like varicosities to 5-hydroxytryptamine-2A receptor-immunoreactive neuronal processes in the rat forebrain. Serotonin 17-36 5-hydroxytryptamine receptor 2A Rattus norvegicus 82-113 11344169-4 2001 Treatment of platelets with the anti-Fc gamma RIIA monoclonal antibody IV.3 specifically inhibits vWF-induced but not thrombin-induced pleckstrin phosphorylation and serotonin secretion. Serotonin 166-175 Fc gamma receptor IIa Homo sapiens 37-50 11443529-1 2001 The promoter polymorphism of the serotonin transporter gene (HTT, locus SLC6A4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. Serotonin 197-206 huntingtin Homo sapiens 61-64 16364229-0 2005 Glucocorticoids and serotonin alter glucocorticoid receptor mRNA levels in fetal guinea-pig hippocampal neurons, in vitro. Serotonin 20-29 glucocorticoid receptor Cavia porcellus 36-59 16364229-5 2005 In the present study, we hypothesised that dexamethasone, cortisol and serotonin exposure would modify GR mRNA expression within fetal guinea-pig hippocampal cultures. Serotonin 71-80 glucocorticoid receptor Cavia porcellus 103-105 16364229-10 2005 Exposure to serotonin (100 nM) significantly increased GR mRNA levels in hippocampal neurons. Serotonin 12-21 glucocorticoid receptor Cavia porcellus 55-57 16364229-11 2005 We conclude that synthetic and endogenous glucocorticoids, as well as serotonin, can influence GR expression during hippocampal development and in this way may act to permanently programme HPA function. Serotonin 70-79 glucocorticoid receptor Cavia porcellus 95-97 11443533-1 2001 The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Serotonin 173-182 solute carrier family 18 member A2 Homo sapiens 4-44 14666410-7 2003 The relationship between changes in NPY-LI and dopamine and serotonin metabolism determined by HPLC was discussed. Serotonin 60-69 neuropeptide Y Mus musculus 36-39 11443533-1 2001 The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Serotonin 173-182 solute carrier family 18 member A2 Homo sapiens 46-50 11443533-1 2001 The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Serotonin 173-182 solute carrier family 18 member A2 Homo sapiens 67-100 11443533-1 2001 The synaptic vesicular monoamine transporter (SVMT), alternatively vesicular monoamine transporter 2 (VMAT2), pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Serotonin 173-182 solute carrier family 18 member A2 Homo sapiens 102-107 11508497-7 2001 Thus, losses of cortical 5-HT2A receptors appears to be the main consequence of hypothyroidism at the level of the serotonin system of the brain. Serotonin 115-124 5-hydroxytryptamine receptor 2A Rattus norvegicus 25-31 15610158-8 2004 Approximately half of these secretin-expressing neurons are immunoreactive for serotonin (5HT) and/or tryptophan hydroxylase. Serotonin 79-88 secretin Mus musculus 28-36 15610158-8 2004 Approximately half of these secretin-expressing neurons are immunoreactive for serotonin (5HT) and/or tryptophan hydroxylase. Serotonin 90-93 secretin Mus musculus 28-36 14625088-1 2003 There are currently no known agents that display selectivity between homomeric 5-hydroxytryptamine type 3A (5-HT3A) and heteromeric 5-HT3A/3B receptors. Serotonin 79-98 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 108-114 11409888-1 2001 Connective tissue growth factor (CTGF) has recently been described as a fibrogenic factor and is greatly induced by various extracellular stimuli, such as transforming growth factor-beta (TGF-beta), dexamethasone, and serotonin. Serotonin 218-227 cellular communication network factor 2 Homo sapiens 0-31 11409888-1 2001 Connective tissue growth factor (CTGF) has recently been described as a fibrogenic factor and is greatly induced by various extracellular stimuli, such as transforming growth factor-beta (TGF-beta), dexamethasone, and serotonin. Serotonin 218-227 cellular communication network factor 2 Homo sapiens 33-37 14597179-10 2003 The 5-HT(3C1) transcript is expressed almost exclusively in small intestine and colon, suggesting a possible role in the serotonin-responsiveness of the gut. Serotonin 121-130 5-hydroxytryptamine receptor 3E Homo sapiens 4-12 14672246-1 2003 BACKGROUND: Dieting in healthy women results in a decrease in the availability of tryptophan (TRP), the amino-acid precursor of serotonin (5-HT), for brain 5-HT synthesis. Serotonin 128-137 POU class 6 homeobox 1 Homo sapiens 150-157 11358440-3 2001 We have previously demonstrated a role for serotonin (5-HT) as one potential modulator of respiratory recovery following cervical hemisection, a mechanism that likely occurs via 5-HT2A and/or 5-HT2C receptors. Serotonin 43-52 5-hydroxytryptamine receptor 2A Rattus norvegicus 178-184 12872296-1 2003 To investigate the modulation of serotonin release in the dorsal raphe nucleus (DRN) by alpha(1) and alpha(2) adrenoceptors, dual-probe microdialysis was performed in conscious rats. Serotonin 33-42 adrenoceptor alpha 2A Rattus norvegicus 101-123 11245847-3 2001 Immunoblots and enzyme assays, performed using [14C]5-hydroxytriptamine and [14C]beta-phenylethylamine as substrates for monoamine oxidases-A and -B, respectively, showed that monoamine oxidase-A is the isoenzyme largely predominant in 9-day-old rats renal cortex. Serotonin 52-71 monoamine oxidase A Rattus norvegicus 121-148 11245847-3 2001 Immunoblots and enzyme assays, performed using [14C]5-hydroxytriptamine and [14C]beta-phenylethylamine as substrates for monoamine oxidases-A and -B, respectively, showed that monoamine oxidase-A is the isoenzyme largely predominant in 9-day-old rats renal cortex. Serotonin 52-71 monoamine oxidase A Rattus norvegicus 176-195 12872296-7 2003 Infusion of the alpha(2A) adrenoceptor antagonist BRL 44408 into the DRN (100 microM) caused an increase of serotonin release in the DRN to 270% of the basal levels, but at the same time no changes were seen in the extracellular levels of serotonin in the PFC. Serotonin 108-117 adrenoceptor alpha 2A Rattus norvegicus 16-38 11167786-3 2001 Of 75 sera with a positive serotonin-release assay (SRA), anti-PF4-heparin of the immunoglobulin (Ig)G class was detected in 72 (96%) sera. Serotonin 27-36 platelet factor 4 Homo sapiens 63-66 12872296-8 2003 The present study demonstrates that alpha(1) as well as alpha(2) adrenoceptors in the DRN modulate the release of serotonin in the DRN, and that alpha(1) adrenoceptors in the DRN are maximally stimulated during resting conditions. Serotonin 114-123 adrenoceptor alpha 2A Rattus norvegicus 56-78 12873938-1 2003 UNLABELLED: Many inhaled anesthetics block the in vitro effect of the excitatory neurotransmitter serotonin on the 5-HT2A receptor, supporting the view that this receptor might mediate the capacity of inhaled anesthetics to produce immobility during noxious stimulation (i.e., would underlie MAC, the minimum alveolar concentration required to suppress movement in response to a noxious stimulus in 50% of subjects). Serotonin 98-107 5-hydroxytryptamine receptor 2A Rattus norvegicus 115-121 12018774-0 2001 Tyrosine hydroxylase expression in differentiating neurons of the rat arcuate nucleus: stimulatory influence of serotonin afferents. Serotonin 112-121 tyrosine hydroxylase Rattus norvegicus 0-20 12018774-1 2001 The influence of serotonin afferents on tyrosine hydroxylase expression in differentiating neurons of the rat arcuate nucleus was studied in vivo and in vitro. Serotonin 17-26 tyrosine hydroxylase Rattus norvegicus 40-60 12934707-4 2003 Studies on mice revealed that 5-HT2C pre-mRNA editing is regulated in a serotonin-dependent manner, and postmortem studies on brain tissues of patients with schizophrenia and major depression found distinct site-specific alterations of this editing in the prefrontal cortex, a brain region expressing a large number of differently edited 5-HT2C mRNA isoforms. Serotonin 72-81 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 30-36 12018774-4 2001 Serotonin depletion significantly decreased the tyrosine hydroxylase content in neurons of males and females at the 21st embryonic day and in males at the 35th postnatal day. Serotonin 0-9 tyrosine hydroxylase Rattus norvegicus 48-68 12018774-8 2001 Thus, our results suggest a stimulatory, long-lasting effect of serotonin afferents on tyrosine hydroxylase expression in the differentiating neurons of the rat arcuate nucleus during prenatal ontogenesis. Serotonin 64-73 tyrosine hydroxylase Rattus norvegicus 87-107 12867508-5 2003 Overexpression of Syt IVQ, but not of Syt I, in Aplysia neurons blocked the ability of serotonin to reverse synaptic depression. Serotonin 87-96 synaptotagmin 1 Homo sapiens 18-21 11104831-0 2000 Estimation of apparent pA2 values for WAY 100635 at 5-HT1A receptors regulating 5-hydroxytryptamine release in anaesthetised rats. Serotonin 80-99 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 11104831-1 2000 5-HT1A receptor agonists decrease 5-hydroxytryptamine (5-HT) terminal release by activating somatodendritic 5-HT1A autoreceptors. Serotonin 34-53 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-6 11104831-1 2000 5-HT1A receptor agonists decrease 5-hydroxytryptamine (5-HT) terminal release by activating somatodendritic 5-HT1A autoreceptors. Serotonin 34-53 5-hydroxytryptamine receptor 1A Rattus norvegicus 108-114 12867508-5 2003 Overexpression of Syt IVQ, but not of Syt I, in Aplysia neurons blocked the ability of serotonin to reverse synaptic depression. Serotonin 87-96 synaptotagmin 1 Homo sapiens 18-23 12958836-1 2003 AIM: To investigate the impact of 8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate (TMB-8) on the change of cerebral blood flow(CBF) induced by 5-HT or KCl in rats. Serotonin 149-153 CCAAT/enhancer binding protein zeta Rattus norvegicus 133-136 10976101-2 2000 Expression of connective tissue growth factor (CTGF) was induced in renal mesangial cells by activation of heptahelical receptors by serotonin (5-HT) and lysophosphatidic acid (LPA). Serotonin 133-142 cellular communication network factor 2 Homo sapiens 14-45 10976101-2 2000 Expression of connective tissue growth factor (CTGF) was induced in renal mesangial cells by activation of heptahelical receptors by serotonin (5-HT) and lysophosphatidic acid (LPA). Serotonin 133-142 cellular communication network factor 2 Homo sapiens 47-51 12958836-10 2003 CONCLUSION: These results indicate that TMB-8 is effective in preventing and treating the reduction of CBF induced by 5-HT or KCl, and improved the supply of blood in rat brain during ischemia. Serotonin 118-122 CCAAT/enhancer binding protein zeta Rattus norvegicus 103-106 12706246-8 2003 In general, our results suggest that GABA(B)R1 and GABA(B)R2 co-exist in the great majority of brainstem catecholamine and serotonin neurons. Serotonin 123-132 gamma-aminobutyric acid (GABA) B receptor, 2 Mus musculus 51-60 12605405-1 2003 We studied the effects of serotonin and noradrenaline on the expression of arginine-vasopressin (AVP) and vasoactive intestinal peptide (VIP) in the suprachiasmatic nucleus (SCN). Serotonin 26-35 arginine vasopressin Mus musculus 75-95 12566091-2 2003 Type A MAO activity in monkey brain decreased to about 50% with 1 microM ZnSO(4) using serotonin as a substrate, and this inhibition was proportional to the concentration of ZnSO(4). Serotonin 87-96 monoamine oxidase A Rattus norvegicus 7-10 12586608-3 2003 Cin.S possessed radical scavenging activity at a comparable level to CS, while CT and Cin.T exhibited lower activity, suggesting that hydroxyl group in serotonin is essential for the antioxidative activity. Serotonin 152-161 pyridoxal phosphatase Homo sapiens 0-3 12624529-15 2003 The data also demonstrate for the first time the existence of a cross-talk between ghrelin and other neurotransmitter systems, such as EAAs and serotonin, in precise control of GH secretion. Serotonin 144-153 ghrelin and obestatin prepropeptide Rattus norvegicus 83-90 12624529-15 2003 The data also demonstrate for the first time the existence of a cross-talk between ghrelin and other neurotransmitter systems, such as EAAs and serotonin, in precise control of GH secretion. Serotonin 144-153 gonadotropin releasing hormone receptor Rattus norvegicus 177-179 12623759-13 2003 The order of serotonin-UGT activities in animal liver microsomes was rat > mouse > human > cow > pig > horse > dog > rabbit > monkey > ferret. Serotonin 13-22 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 23-26 12623759-17 2003 This assay provides a novel sensitive and specific technique for the measurement of serotonin-UGT activity in vitro. Serotonin 84-93 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 94-97 12498921-2 2003 All four agonists increased right atrial adenylyl cyclase activity and contractile force, whereby increases for terbutaline, histamine and serotonin, but not for noradrenaline, were significantly larger in right atria from beta(1)-adrenoceptor antagonist-treated vs. non-beta(1)-adrenoceptor antagonist-treated patients. Serotonin 139-148 adrenoceptor beta 1 Homo sapiens 223-243 12480131-0 2002 Effects of elevated serotonin levels on patterns of GAP-43 expression during barrel development in rat somatosensory cortex. Serotonin 20-29 growth associated protein 43 Rattus norvegicus 52-58 12480131-1 2002 Elevating cortical serotonin (5-HT) in rats with clorgyline, a monoamine oxidase A (MAO(A)) inhibitor, from postnatal day (P-0) to P-6 delays the organization of thalamocortical afferent fibers into a vibrissae-related pattern in the somatosensory cortex (S-I). Serotonin 19-28 monoamine oxidase A Rattus norvegicus 63-82 12480131-1 2002 Elevating cortical serotonin (5-HT) in rats with clorgyline, a monoamine oxidase A (MAO(A)) inhibitor, from postnatal day (P-0) to P-6 delays the organization of thalamocortical afferent fibers into a vibrissae-related pattern in the somatosensory cortex (S-I). Serotonin 19-28 monoamine oxidase A Rattus norvegicus 84-90 12213812-0 2002 Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells. Serotonin 0-9 mitogen activated protein kinase 3 Rattus norvegicus 91-97 12431860-0 2002 Serotonin modulates early cortical auditory processing in healthy subjects: evidence from MEG with acute tryptophan depletion. Serotonin 0-9 protein tyrosine phosphatase non-receptor type 4 Homo sapiens 90-93 12384226-8 2002 These results may reflect up-regulation of 5-HT1A gene transcription in response to deficits in hippocampal serotonin neurotransmission induced by social isolation. Serotonin 108-117 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-49 12361392-7 2002 Thus, besides an electron-withdrawing field effect and ortho substitution, which both influence binding to serotonin 5-HT receptor subtypes, though to a different extent as revealed by regression coefficients in the multiparametric regression equations, the affinity of congeners 1a-r to 5-HT(1A) receptors proved to be linearly correlated with volume/polarizability descriptors, whereas their affinity to 5-HT(2A) receptors correlated with lipophilicity constants through a parabolic relationship. Serotonin 107-116 5-hydroxytryptamine receptor 1A Rattus norvegicus 288-295 12387620-0 2002 Inhibition of the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes by a putative aberrant metabolite of serotonin, tryptamine-4,5-dione. Serotonin 126-135 oxoglutarate dehydrogenase Rattus norvegicus 18-51 12231467-1 2002 Stimulation of serotonin receptor subtypes 5-HT(2A) or 5-HT(2C) in stably transfected 3T3 cells by dexnorfenfluramine (DEXNOR) or serotonin increases secretion of the APP metabolite APP(s). Serotonin 130-139 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 55-62 15557178-4 2004 We first demonstrate that Siglecs-7 and -9 are able to inhibit the FcepsilonRI-mediated serotonin release from RBL cells following co-crosslinking. Serotonin 88-97 sialic acid binding Ig like lectin 7 Homo sapiens 26-42 12210276-1 2002 Phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine, shares physical, structural and catalytic properties with tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) that catalyze the rate-limiting steps in the biosynthesis of the neurotransmitters dopamine, noradrenaline, and serotonin. Serotonin 323-332 phenylalanine hydroxylase Homo sapiens 0-25 15522306-5 2004 Genetic interactions between tax-6 and several mutants including egl-30 and egl-10, which are known to be involved in G-protein signaling pathways suggest that calcineurin indeed regulates locomotion and serotonin-mediated egg laying through goa-1(Goalpha) and egl-30(Gqalpha). Serotonin 204-213 Serine/threonine-protein phosphatase 2B catalytic subunit Caenorhabditis elegans 29-34 15541318-0 2004 ApTrkl, a Trk-like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neurons. Serotonin 38-47 neurotrophic receptor tyrosine kinase 1 Homo sapiens 2-5 12210276-1 2002 Phenylalanine hydroxylase (PAH), which catalyzes the conversion of phenylalanine to tyrosine, shares physical, structural and catalytic properties with tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) that catalyze the rate-limiting steps in the biosynthesis of the neurotransmitters dopamine, noradrenaline, and serotonin. Serotonin 323-332 phenylalanine hydroxylase Homo sapiens 27-30 15541318-5 2004 Finally, inhibiting the activation of ApTrkl with the Trk inhibitor K252a or using dsRNA to inhibit ApTrkl blocks the serotonin-mediated activation of ERK in the cell body, as well as the cell-wide long-term facilitation induced by 5-HT application to the cell body. Serotonin 118-127 neurotrophic receptor tyrosine kinase 1 Homo sapiens 40-43 12135927-5 2002 unc-86-null mutations affect the expression in NSM of tph-1, which encodes the serotonin synthetic enzyme tryptophan hydroxylase, and cat-1, which encodes a vesicular transporter that loads serotonin into synaptic vesicles, suggesting that unc-86 coordinately regulates serotonin synthesis and packaging. Serotonin 79-88 Transcription factor unc-86 Caenorhabditis elegans 0-6 12135927-5 2002 unc-86-null mutations affect the expression in NSM of tph-1, which encodes the serotonin synthetic enzyme tryptophan hydroxylase, and cat-1, which encodes a vesicular transporter that loads serotonin into synaptic vesicles, suggesting that unc-86 coordinately regulates serotonin synthesis and packaging. Serotonin 190-199 Transcription factor unc-86 Caenorhabditis elegans 0-6 12135927-5 2002 unc-86-null mutations affect the expression in NSM of tph-1, which encodes the serotonin synthetic enzyme tryptophan hydroxylase, and cat-1, which encodes a vesicular transporter that loads serotonin into synaptic vesicles, suggesting that unc-86 coordinately regulates serotonin synthesis and packaging. Serotonin 190-199 Transcription factor unc-86 Caenorhabditis elegans 0-6 15351283-1 2004 A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS). Serotonin 225-245 monoamine oxidase A Rattus norvegicus 83-115 15351283-1 2004 A simple and selective assay for the evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors was developed through the simultaneous determination of endogenous 5-hydroxy tryptamine, 5-hydroxyindole-3-acetic acid (5-HIAA), tryptophane, and 2-phenethylamine (PEA) in rat brain using liquid chromatography-tandem mass spectrometry (LC/MS/MS). Serotonin 225-245 monoamine oxidase A Rattus norvegicus 103-106 12137973-5 2002 The vasorelaxing effect of PACAP was assessed in arteries precontracted by serotonin in the absence or presence of different test compounds known to selectively inhibit certain signaling proteins. Serotonin 75-84 adenylate cyclase activating polypeptide 1 Rattus norvegicus 27-32 15271993-8 2004 We find that chicken SERT is capable of discriminating between different serotonin-selective reuptake inhibitors; thus, the potency of S-citalopram and paroxetine is reduced more than 40-fold. Serotonin 73-82 solute carrier family 6 member 4 Gallus gallus 21-25 12057843-0 2002 Withdrawal from chronic ethanol increases the sensitivity of presynaptic 5-HT(1A) receptors modulating serotonin and dopamine synthesis in rat brain in vivo. Serotonin 103-112 5-hydroxytryptamine receptor 1A Rattus norvegicus 73-80 12057843-1 2002 The in vivo sensitivity of presynaptic 5-HT(1A) receptors (autoreceptors and heteroreceptors) modulating the synthesis of 5-hydroxytryptophan/serotonin (5-HTP/5-HT) and 3,4-dihydroxyphenylalanine/dopamine (DOPA/DA) in rat brain was investigated after ethanol treatment and withdrawal. Serotonin 142-151 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-46 14741057-1 2004 Chronic administration of several antidepressants, notably the selective serotonin re-uptake inhibitors (SSRIs) induces sub-sensitivity of post-synaptic 5-HT1A receptors in the hypothalamus. Serotonin 73-82 5-hydroxytryptamine receptor 1A Rattus norvegicus 153-159 12077195-1 2002 Mice lacking monoamine oxidase A (MAOA) display high levels of brain serotonin during the first postnatal week, causing an exuberant outgrowth of thalamocortical axons (TCAs) in layer IV of the somatosensory cortex (S1). Serotonin 69-78 monoamine oxidase A Mus musculus 13-32 12077195-1 2002 Mice lacking monoamine oxidase A (MAOA) display high levels of brain serotonin during the first postnatal week, causing an exuberant outgrowth of thalamocortical axons (TCAs) in layer IV of the somatosensory cortex (S1). Serotonin 69-78 monoamine oxidase A Mus musculus 34-38 12028362-1 2002 Monoamine oxidase-A knockout (MAO-A KO) mice have elevated brain serotonin (5-HT) and noradrenaline (NA) levels, and one would therefore anticipate increased monoamine release and compensatory changes in other aspects of presynaptic monoamine function. Serotonin 65-74 monoamine oxidase A Mus musculus 0-19 15342106-12 2004 Both 5-HT1A, 5-HT2A and 5-HT2C receptors seem to mediate the inhibitory action of serotonin on escape. Serotonin 82-91 5-hydroxytryptamine receptor 1A Rattus norvegicus 5-11 15342106-12 2004 Both 5-HT1A, 5-HT2A and 5-HT2C receptors seem to mediate the inhibitory action of serotonin on escape. Serotonin 82-91 5-hydroxytryptamine receptor 2A Rattus norvegicus 13-25 15258112-1 2004 Serotonin is a specific in vitro substrate for human UDP-glucuronosyltransferase (UGT) 1A6. Serotonin 0-9 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 53-90 15258112-2 2004 In this study, the contribution of UGT1A6 to the glucuronidation of endogenous structural analogs of serotonin, including 5-hydroxytryptophol, N-acetylserotonin, and 6-hydroxymelatonin, was evaluated using available recombinant human UGT isoforms, human liver microsomes, and liver microsomes from animals that do not express functional UGT1A6 (Gunn rats and cats). Serotonin 101-110 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 35-41 15258112-2 2004 In this study, the contribution of UGT1A6 to the glucuronidation of endogenous structural analogs of serotonin, including 5-hydroxytryptophol, N-acetylserotonin, and 6-hydroxymelatonin, was evaluated using available recombinant human UGT isoforms, human liver microsomes, and liver microsomes from animals that do not express functional UGT1A6 (Gunn rats and cats). Serotonin 101-110 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 35-38 15258112-2 2004 In this study, the contribution of UGT1A6 to the glucuronidation of endogenous structural analogs of serotonin, including 5-hydroxytryptophol, N-acetylserotonin, and 6-hydroxymelatonin, was evaluated using available recombinant human UGT isoforms, human liver microsomes, and liver microsomes from animals that do not express functional UGT1A6 (Gunn rats and cats). Serotonin 101-110 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 337-343 11971705-2 2002 Unlike unconjugated nanocrystals, SNACs were found to dose-dependently inhibit transport of radiolabeled serotonin by hSERT and dSERT, with an estimated half-maximal activity (EC(50)) of 33 (dSERT) and 99 microM (hSERT). Serotonin 105-114 Serotonin transporter Drosophila melanogaster 128-133 11826118-1 2002 The disruptive effect of excessive serotonin (5-HT) levels on the development of cortical sensory maps is mediated by 5-HT1B receptors, as shown in barrelless monoamine oxidase A knock-out mice, in which the additional inactivation of 5-HT1B receptors restores the barrels. Serotonin 35-44 monoamine oxidase A Mus musculus 159-178 15309378-1 2004 Desensitisation of 5-HT(1A) and 5-HT(1B) autoreceptors is thought to be the mechanism underlying the therapeutic effects of fluoxetine and other selective serotonin re-uptake inhibitors (SSRIs) when these are administered chronically, while blockade of these autoreceptors occurring on administration of an SSRI together with an autoreceptor antagonist is responsible for the acute increase in 5-HT levels in vivo observed under these circumstances. Serotonin 155-164 5-hydroxytryptamine receptor 1A Rattus norvegicus 19-26 11743222-6 2002 In contrast, naftidrofuryl markedly attenuated serotonin-induced renal vasoconstriction and nearly completely blocked serotonin"s renin inhibitory properties in isolated perfused rat kidney. Serotonin 118-127 renin Rattus norvegicus 130-135 15219613-0 2004 Toward brain imaging of serotonin 5-HT1A autoreceptor internalization. Serotonin 24-33 5-hydroxytryptamine receptor 1A Rattus norvegicus 34-40 15080502-0 2002 Autoradiographic analysis of 5-hydroxytryptamine 5-HT2A binding sites in the rat brain after chronic intragastric ethanol treatments. Serotonin 29-48 5-hydroxytryptamine receptor 2A Rattus norvegicus 49-55 15201326-2 2004 A valine to serine mutation (V13"S) in the channel-lining M2 domain of the 5-HT3A receptor subunit rendered the 5-HT3 receptor 70-fold more sensitive to serotonin and produced constitutive activity when combined with the 5-HT3B subunit. Serotonin 153-162 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 75-81 15190115-1 2004 Because 5-HT1A receptors located on the soma dendrites of serotonin (5-HT) neurons normally mediate an inhibition of 5-HT firing and release, the desensitization of these autoreceptors is essential for obtaining an enhancement of 5-HT transmission after treatment with 5-HT reuptake inhibitors (SSRIs). Serotonin 58-67 5-hydroxytryptamine receptor 1A Rattus norvegicus 8-14 12467090-4 2001 A significant increase in serotonin uptake (+37% + 14, M + SD) was observed in the control group, whereas neither the generalized anxiety disorder nor the major depression group exhibited changes in serotonin uptake upon incubation with cortisol. Serotonin 26-35 MSD Homo sapiens 55-61 15065122-1 2004 Serotonin (5-HT) plays a major role at the spinal level by modulating most spinal functions through several receptor subtypes including the 5-HT2A receptor. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 140-146 15065122-10 2004 The main result of our study was the "nonsynaptic" plasma membrane localization of 5-HT2A receptors covering a large surface of cell bodies and dendrites, suggesting a paracrine form of action of serotonin. Serotonin 196-205 5-hydroxytryptamine receptor 2A Rattus norvegicus 83-89 14997015-0 2004 Role of serotonin on cocaine-mediated effects on prodynorphin gene expression in the rat brain. Serotonin 8-17 prodynorphin Rattus norvegicus 49-61 11124584-0 2000 Serotonin inhibits luteinizing hormone release via 5-HT1A receptors in the zona incerta of ovariectomised, anaesthetised rats primed with steroids. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 51-57 11723272-2 2001 OBJECTIVE: To evaluate the possibility that serotoninergic 5-HT1A autoreceptors (by regulating the release of serotonin as well as dopamine formed from exogenous levodopa) affect the response alterations complicating levodopa treatment of PD. Serotonin 44-53 5-hydroxytryptamine receptor 1A Rattus norvegicus 59-65 11501051-3 2000 MAO activity was determined radiochemically with [14C]5-hydroxytryptamine (5-HT) and [14C]beta-phenylethylamine (beta-PEA) used as MAO A or B specific radiolabled substrates, respectively. Serotonin 75-79 monoamine oxidase A Rattus norvegicus 0-3 15648445-4 2004 Three of the GPCRs (serotonin 1A, 1D, and dopamine D2) were functionally redirected into a Gq-type pathway when coexpressed with the chimeric G proteins, compared with only one (serotonin 1A) with Galpha16. Serotonin 20-29 G protein subunit alpha 15 Homo sapiens 197-205 11564723-9 2001 These results suggest that free T(3) and/or IGF-I, affecting dopamine and serotonin systems in the central nervous system, may mediate the enhanced locomotor activity observed in transgenic mice with general overexpression of bovine GH. Serotonin 74-83 insulin-like growth factor 1 Mus musculus 44-49 15316241-12 2004 Serotonin (0.1-100 microM) impaired the inhibitory effect of the 5-HT(1A) antagonist (10 microM). Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 65-72 14697876-12 2004 MAO-A knockout mice exhibit increased serotonin levels and aggressive behavior, whereas MAO-B knockout mice show little behavioral change. Serotonin 38-47 monoamine oxidase A Mus musculus 0-5 10900078-1 2000 Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin (5-HT) belongs to the aromatic amino acid hydroxylase superfamily, which includes phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH). Serotonin 99-108 phenylalanine hydroxylase Homo sapiens 191-216 11669473-3 2001 VMAT2 differs from the plasma membrane transporters in its capability to recognize serotonin, histamine, norepinephrine and dopamine with almost the same affinity. Serotonin 83-92 solute carrier family 18 member A2 Homo sapiens 0-5 10927191-1 2000 Catecholamines and serotonin, which act as neurotransmitters and regulate blood circulation, are degraded by monoamine oxidase (MAO) [EC 1.4.3.4.] Serotonin 19-28 monoamine oxidase A Rattus norvegicus 109-126 10927191-1 2000 Catecholamines and serotonin, which act as neurotransmitters and regulate blood circulation, are degraded by monoamine oxidase (MAO) [EC 1.4.3.4.] Serotonin 19-28 monoamine oxidase A Rattus norvegicus 128-131 14697877-5 2004 MAO A KO mice showed increased levels of serotonin (5-HT), norepinephrine (NE), dopamine (DA) whereas MAO B KO mice showed increased phenylethylamine (PEA) levels only. Serotonin 41-50 monoamine oxidase A Mus musculus 0-5 14614947-0 2003 Characterization of a novel effect of serotonin 5-HT1A and 5-HT2A receptors: increasing cGMP levels in rat frontal cortex. Serotonin 38-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 48-60 11533135-2 2001 The time course of macroscopic current responses of homomeric murine serotonin 5-HT3A receptors was studied in whole cells and excised membrane patches under voltage clamp in response to rapid application of serotonin. Serotonin 69-78 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 79-85 14614947-11 2003 In summary, activation of serotonin 5-HT1A and 5-HT2A receptors increase brain cGMP levels. Serotonin 26-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 36-48 10660896-1 2000 The 5-HT1A and 5-HT1B receptors of serotonin play important roles as auto- and heteroreceptors controlling the release of serotonin itself and of other neurotransmitters/modulators in the central nervous system (CNS). Serotonin 35-44 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-21 10660896-1 2000 The 5-HT1A and 5-HT1B receptors of serotonin play important roles as auto- and heteroreceptors controlling the release of serotonin itself and of other neurotransmitters/modulators in the central nervous system (CNS). Serotonin 122-131 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-21 10660896-9 2000 Because the 5-HT1A receptors are somatodendritic, they are ideally situated to mediate serotonin effects on neuronal firing, both as auto- and as heteroreceptors. Serotonin 87-96 5-hydroxytryptamine receptor 1A Rattus norvegicus 12-18 14602809-3 2003 Here we show that the Lim class homeobox gene Lmx1b is required for proper formation of the entire 5-HT system in the hindbrain, as indicated by the loss of expression of genes necessary for serotonin synthesis and transport in Lmx1b null mice. Serotonin 191-200 PDZ and LIM domain 5 Mus musculus 22-25 11533135-10 2001 The 5-HT3A receptor response to 100 microM serotonin in outside-out patches (n = 19) and whole cells (n = 41) desensitized with a variable rate that accelerated throughout the experiment. Serotonin 43-52 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 4-10 14602809-3 2003 Here we show that the Lim class homeobox gene Lmx1b is required for proper formation of the entire 5-HT system in the hindbrain, as indicated by the loss of expression of genes necessary for serotonin synthesis and transport in Lmx1b null mice. Serotonin 191-200 LIM homeobox transcription factor 1 beta Mus musculus 46-51 11533135-19 2001 Simultaneously fitting the macroscopic 5-HT3A receptor responses in patches to submaximal (2 microM) and maximal (100 microM) concentrations of serotonin to a variety of state models suggests that homomeric 5-HT3A receptors require the binding of three agonists to open and possess a peak open probability greater than 0.8. Serotonin 144-153 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 39-45 14622114-2 2003 The stimulation of prefrontal 5-HT2A and AMPA receptors increases pyramidal and serotonergic cell firing, and 5-hydroxytryptamine (5-HT) release in mPFC. Serotonin 110-129 5-hydroxytryptamine receptor 2A Rattus norvegicus 30-36 10651142-0 2000 Inhibition of serotonin release in the mouse brain via presynaptic cannabinoid CB1 receptors. Serotonin 14-23 cannabinoid receptor 1 (brain) Mus musculus 79-82 10651142-4 2000 In superfused mouse cortex membranes preincubated with [3H]serotonin, the electrically evoked tritium overflow was inhibited by the cannabinoid receptor agonist WIN 55,212-2 (maximum effect of 20%, obtained at 1 microM; pEC50=7.11) and this effect was counteracted by the CB1 receptor antagonist SR 141716 (apparent pA2=8.02), which did not affect the evoked tritium overflow by itself. Serotonin 59-68 cannabinoid receptor 1 (brain) Mus musculus 272-275 11533135-19 2001 Simultaneously fitting the macroscopic 5-HT3A receptor responses in patches to submaximal (2 microM) and maximal (100 microM) concentrations of serotonin to a variety of state models suggests that homomeric 5-HT3A receptors require the binding of three agonists to open and possess a peak open probability greater than 0.8. Serotonin 144-153 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 207-213 10651142-11 2000 In conclusion, serotonin release in the mouse brain cortex is inhibited via CB1 receptors, which may be located presynaptically and are not activated by endogenous cannabinoids. Serotonin 15-24 cannabinoid receptor 1 (brain) Mus musculus 76-79 12972688-2 2003 MAO-A activity increased to about 40% with 0.1 microM calcium disodium edetate (CaNa2EDTA) using serotonin as a substrate, and this activation was proportional to the concentration of CaNa2EDTA. Serotonin 97-106 monoamine oxidase A Rattus norvegicus 0-5 12972688-9 2003 These results also indicate the possibility that Zn ions may regulate physiologically the level of serotonin and norepinephrine content in brain by inhibiting a MAO-A activity. Serotonin 99-108 monoamine oxidase A Rattus norvegicus 161-166 12018584-0 2001 Serotonin and benzylamine oxidation by type A and type B MAO of rat brain in presence of organophosphate pesticides. Serotonin 0-9 monoamine oxidase A Rattus norvegicus 57-60 14609545-3 2003 Recently, the excessive aggressive and impulsive traits of neuronal NO synthase knockout (nNOS-/-) mice were shown to be caused by reductions in serotonin (5-HT) turnover and deficient 5-HT1A and 5-HT1B receptor function in brain regions regulating emotion. Serotonin 145-154 nitric oxide synthase 1, neuronal Mus musculus 90-94 11113335-1 2000 Mice deficient in monoamine oxidase A have previously been shown to demonstrate a chronic elevation of serotonin and norepinephrine in the brain. Serotonin 103-112 monoamine oxidase A Mus musculus 18-37 11454416-1 2001 Elevating cortical serotonin (5-HT) in rats from postnatal day (P-) 0 to P-6 by administering the monoamine oxidase (MAO(A)) inhibitor, clorgyline, produces a dose-dependent spectrum of effects on rat somatosensory organization, ranging from enlarged with indistinct septa to a complete lack of vibrissae-related patterns. Serotonin 19-28 monoamine oxidase A Rattus norvegicus 98-115 10682715-16 2000 The released serotonin could contribute to the inhibition of off(M) cells and excitation of on(M) cells by noxious stimulation, since inhibitory 5-HT1a receptors and excitatory 5-HT2 receptors, respectively, have previously been shown to dominate their serotonergic responses. Serotonin 13-22 5-hydroxytryptamine receptor 1A Rattus norvegicus 145-151 12960198-0 2003 A reduced extracellular serotonin level increases the 5-HT1A PET ligand 18F-MPPF binding in the rat hippocampus. Serotonin 24-33 5-hydroxytryptamine receptor 1A Rattus norvegicus 54-60 12873793-2 2003 There are evidence that increased serotonin metabolism may be involved in leptin actions. Serotonin 34-43 leptin Rattus norvegicus 74-80 12873793-8 2003 At the 0-20 min interval, serotonin release was significantly higher after leptin (42+/-12% above baseline) than after CSF (6+/-5%) and the maximal increase after leptin was of 126+/-53% above baseline (100-120 min, p>0.05 vs. CSF). Serotonin 26-35 leptin Rattus norvegicus 75-81 11454416-1 2001 Elevating cortical serotonin (5-HT) in rats from postnatal day (P-) 0 to P-6 by administering the monoamine oxidase (MAO(A)) inhibitor, clorgyline, produces a dose-dependent spectrum of effects on rat somatosensory organization, ranging from enlarged with indistinct septa to a complete lack of vibrissae-related patterns. Serotonin 19-28 monoamine oxidase A Rattus norvegicus 117-123 12873793-8 2003 At the 0-20 min interval, serotonin release was significantly higher after leptin (42+/-12% above baseline) than after CSF (6+/-5%) and the maximal increase after leptin was of 126+/-53% above baseline (100-120 min, p>0.05 vs. CSF). Serotonin 26-35 leptin Rattus norvegicus 163-169 10647096-2 1999 Given the putative role of the medial prefrontal cortex (mPFC) in negative symptoms of schizophrenia, the aim of this study was to assess the effects of clozapine on the dopamine- and serotonin-responsive neurons in that particular brain structure. Serotonin 184-193 complement factor properdin Mus musculus 57-61 11334797-0 2001 Further evidence that extracellular serotonin in the rostral ventrolateral medulla modulates 5-HT(1A) receptor-mediated attenuation of exercise pressor reflex. Serotonin 36-45 5-hydroxytryptamine receptor 1A Rattus norvegicus 93-100 10559704-0 1999 Effects of serotonin-selective and classical antidepressants on the auditory P300 cognitive potential. Serotonin 11-20 E1A binding protein p300 Homo sapiens 77-81 10559704-8 1999 It can be concluded that serotonin selective drugs have a slower onset of P300 amplitude decrease than clomipramine, which has additional effects on monoaminergic and on cholinergic systems. Serotonin 25-34 E1A binding protein p300 Homo sapiens 74-78 12899690-5 2003 Serotonin was also metabolized to 5-hydroxytryptophol and 5-hydroxyindole acetic acid, probably through stepwise transformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase. Serotonin 0-9 aldo-keto reductase family 1, member A1 (aldehyde reductase) Mus musculus 187-205 11298363-1 2001 Serotonin (5-hydroxytryptamine [5-HT]) modulates dopamine-related cognitive functions and motor activity through activation of selective receptor subtypes including 5-HT1A. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 165-171 12871984-6 2003 In PETs, VMAT1 was found exclusively in all serotonin-containing tumors. Serotonin 44-53 solute carrier family 18 member A1 Homo sapiens 9-14 10548268-7 1999 In conclusion, the present results showing that several MAO inhibitors decreased ethanol self-administration in rats are consistent with previous findings that synaptic levels of serotonin and dopamine play a critical role in the control of ethanol self-administration. Serotonin 179-188 monoamine oxidase A Rattus norvegicus 56-59 11298363-1 2001 Serotonin (5-hydroxytryptamine [5-HT]) modulates dopamine-related cognitive functions and motor activity through activation of selective receptor subtypes including 5-HT1A. Serotonin 11-30 5-hydroxytryptamine receptor 1A Rattus norvegicus 165-171 11319770-3 2001 In neonatal striatal astrocytes, serotonin increases both cAMP and NGF, whereas, in neonatal cerebellar astrocytes, serotonin decreases both. Serotonin 33-42 nerve growth factor Rattus norvegicus 67-70 10536203-1 1999 We tested the neuroprotective effect of a novel, high affinity serotonin (5-HT1A) agonist, BAY X3702, in a rat model of acute subdural hematoma (ASDH). Serotonin 63-72 5-hydroxytryptamine receptor 1A Rattus norvegicus 74-80 10528148-1 1999 5-HT(1A) receptor antagonists have been suggested to increase the efficacy of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors in the treatment of depression by enhancing the increase in brain 5-HT induced by 5-HT reuptake blockade. Serotonin 88-97 POU class 6 homeobox 1 Rattus norvegicus 206-213 12861437-3 2003 The in vitro contractile response elicited by serotonin (5-HT, 10 micro M) in the rat gastric fundus (5-HT(2B) receptor system) was rapid and followed by a partial fade to a steady state, in contrast with the rat thoracic aorta response (5-HT(2A) receptor system), which was more stable, slower and sustained. Serotonin 46-55 5-hydroxytryptamine receptor 2A Rattus norvegicus 238-245 12738797-5 2003 Serotonin prevents cytochrome c release and caspase-9 and -3 activation after serum deprivation via cross-talks between phosphatidylinositol-3 kinase/Akt and extracellular signal-regulated kinase (ERK) 1/2 signaling pathways. Serotonin 0-9 caspase 9 Mus musculus 44-60 12738797-5 2003 Serotonin prevents cytochrome c release and caspase-9 and -3 activation after serum deprivation via cross-talks between phosphatidylinositol-3 kinase/Akt and extracellular signal-regulated kinase (ERK) 1/2 signaling pathways. Serotonin 0-9 mitogen-activated protein kinase 3 Mus musculus 158-205 12682215-2 2003 hSERT and dSERT showed similar Km values for 5-hydroxytryptamine (5-HT; serotonin) transport (1.2 and 0.9 micro M, respectively), suggesting similar recognition of 5-HT by the two species variants. Serotonin 45-64 Serotonin transporter Drosophila melanogaster 10-15 12682215-2 2003 hSERT and dSERT showed similar Km values for 5-hydroxytryptamine (5-HT; serotonin) transport (1.2 and 0.9 micro M, respectively), suggesting similar recognition of 5-HT by the two species variants. Serotonin 72-81 Serotonin transporter Drosophila melanogaster 10-15 12783521-1 2003 Using unnatural amino acid mutagenesis, the binding site for serotonin at the novel Caenorhabditis elegans receptor MOD-1 has been probed. Serotonin 61-70 Uncharacterized protein Caenorhabditis elegans 116-121 10528148-1 1999 5-HT(1A) receptor antagonists have been suggested to increase the efficacy of selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitors in the treatment of depression by enhancing the increase in brain 5-HT induced by 5-HT reuptake blockade. Serotonin 99-118 POU class 6 homeobox 1 Rattus norvegicus 206-213 12783521-2 2003 As with the closely related serotonin receptor 5-HT3, MOD-1 makes use of a strong cation-pi interaction between the ammonium of serotonin and the indole side chain of a tryptophan. Serotonin 28-37 Uncharacterized protein Caenorhabditis elegans 54-59 11319770-8 2001 However, adult striatal astrocytes responded to serotonin with an elevation of both cAMP and NGF, whereas isoproterenol could only enhance cAMP, without affecting NGF. Serotonin 48-57 nerve growth factor Rattus norvegicus 93-96 11319770-10 2001 In contrast, adult astrocytes were not responsive: Although cAMP changes were large, NGF synthesis was increased only in striatal astrocytes and only in response to serotonin. Serotonin 165-174 nerve growth factor Rattus norvegicus 85-88 11264169-7 2001 Gr B mediates the cytotoxic activity of mast cells, and TPH is a rate-limiting enzyme for the synthesis of serotonin. Serotonin 107-116 granzyme B Mus musculus 0-4 12646175-5 2003 The neurotransmitters, which were implicated in sleep/wake regulation, affected the activity of orexin neurons; noradrenaline and serotonin hyperpolarized, while carbachol depolarized orexin neurons in either the presence or absence of tetrodotoxin. Serotonin 130-139 hypocretin Mus musculus 96-102 11259559-7 2001 Furthermore, the coadministration of a 5-HT(1A) antagonist, p-MPPI, and a previously ineffective dose of fluoxetine, a drug combination that increases serotonin levels, significantly elevated thresholds. Serotonin 151-160 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-46 12605405-2 2003 We used transgenic Tg8 mice knockout for the MAO-A (monoamine oxidase A) gene, which are characterized by increased amounts of serotonin and noradrenaline in brain compared to wild-type mice (C3H). Serotonin 127-136 monoamine oxidase A Mus musculus 45-50 12605405-2 2003 We used transgenic Tg8 mice knockout for the MAO-A (monoamine oxidase A) gene, which are characterized by increased amounts of serotonin and noradrenaline in brain compared to wild-type mice (C3H). Serotonin 127-136 monoamine oxidase A Mus musculus 52-71 12605405-5 2003 Inhibiting serotonin or noradrenaline synthesis in Tg8 mice by the administration of parachlorophenylalanine or alpha-methylparatyrosine, respectively, the amounts of AVP, VIP and their mRNAs were decreased, but not the number of peptidergic neurons. Serotonin 11-20 arginine vasopressin Mus musculus 167-170 12605405-6 2003 This study indicates that serotonin and noradrenaline stimulate AVP and VIP expression, and could participate in the differentiation of the neurochemical phenotype in the mouse SCN. Serotonin 26-35 arginine vasopressin Mus musculus 64-67 10550492-13 1999 CONCLUSIONS: Since agonists at the 5-HT(1A) and 5-HT(2) receptors both reduced impulsivity in this procedure, these data suggest that serotonin may promote "reflection" in this procedure via stimulation of these receptor subtypes. Serotonin 134-143 5-hydroxytryptamine receptor 1A Rattus norvegicus 35-42 10381550-1 1999 The regulation of striatal preprotachykinin (PPT) mRNA expression can be mediated through both dopamine (DA) D1 and serotonin (5-HT) 5-HT2A/2C receptors. Serotonin 116-125 tachykinin, precursor 1 Rattus norvegicus 27-43 12586314-2 2003 In rats, thyrotropin-releasing hormone (TRH) mediates serotonin-induced secretion of GH. Serotonin 54-63 thyrotropin releasing hormone Rattus norvegicus 9-38 11259563-1 2001 Serotonin (5-hydroxytryptamine; 5-HT) 5-HT(2A) receptors have been shown to modulate dopamine (DA) function and a more thorough appreciation of this modulatory interaction between 5-HT2A receptors and DA systems may yield insight into novel approaches to treatment of cocaine dependence. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 180-186 12586314-2 2003 In rats, thyrotropin-releasing hormone (TRH) mediates serotonin-induced secretion of GH. Serotonin 54-63 thyrotropin releasing hormone Rattus norvegicus 40-43 10381550-1 1999 The regulation of striatal preprotachykinin (PPT) mRNA expression can be mediated through both dopamine (DA) D1 and serotonin (5-HT) 5-HT2A/2C receptors. Serotonin 116-125 tachykinin, precursor 1 Rattus norvegicus 45-48 11259563-1 2001 Serotonin (5-hydroxytryptamine; 5-HT) 5-HT(2A) receptors have been shown to modulate dopamine (DA) function and a more thorough appreciation of this modulatory interaction between 5-HT2A receptors and DA systems may yield insight into novel approaches to treatment of cocaine dependence. Serotonin 11-30 5-hydroxytryptamine receptor 2A Rattus norvegicus 180-186 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Serotonin 242-251 GTP cyclohydrolase I feedback regulator Homo sapiens 0-48 10437624-6 1999 We have previously suggested that serotonin may decrease food intake by inhibiting neuropeptide Y neurones, and we further suggest that it also inhibits leptin, possibly by an effect on white adipose tissue. Serotonin 34-43 leptin Rattus norvegicus 153-159 12686747-2 2003 After preincubation at 25 degrees C for 20 min with 1 microM ZnSO(4), MAO-A activity in monkey brain was about 50% using serotonin (5-HT) as a substrate, and the inhibition was proportional to the concentration of ZnSO(4). Serotonin 121-130 monoamine oxidase A Rattus norvegicus 70-75 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Serotonin 242-251 GTP cyclohydrolase I feedback regulator Homo sapiens 50-54 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Serotonin 242-251 GTP cyclohydrolase 1 Homo sapiens 0-20 12464610-3 2003 One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine. Serotonin 70-79 amine oxidase, copper containing 1 Rattus norvegicus 31-52 11274478-1 2001 GTP cyclohydrolase I feedback regulatory protein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4), which is an essential cofactor for key enzymes producing catecholamines, serotonin, and nitric oxide as well as phenylalanine hydroxylase. Serotonin 242-251 phenylalanine hydroxylase Homo sapiens 281-306 12464610-3 2003 One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine. Serotonin 70-79 amine oxidase, copper containing 1 Rattus norvegicus 54-57 10380960-1 1999 5-HTt1A receptor agonists reduce the neuronal release of 5-hydroxytryptamine (5-HT) by activation of raphe 5-HT1A autoreceptors. Serotonin 57-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 107-113 11166334-9 2001 one hour before dissection reduced PGE(2) to detection level and inhibited the CGRP secretion evoked by the combination of bradykinin, serotonin and histamine (all 10(-6) M). Serotonin 135-144 calcitonin-related polypeptide alpha Rattus norvegicus 79-83 15206788-7 2003 Moreover, we experimented alpha-methyl-5-HT (alpha-me-5-HT) and 5-carboxamidotryptamine (5-CT), selective agonists at 5-HT2A and 5-HT1B receptors, respectively. Serotonin 39-43 5-hydroxytryptamine receptor 2A Rattus norvegicus 118-135 11166521-0 2001 Role of 5-HT(2a) and 5-HT(2B/2C) receptors in the behavioral interactions between serotonin and catecholamine reuptake inhibitors. Serotonin 82-91 5-hydroxytryptamine receptor 2A Rattus norvegicus 8-15 11249962-0 2001 Substrates and temperature differentiate ion flux from serotonin flux in a serotonin transporter. Serotonin 55-64 Serotonin transporter Drosophila melanogaster 75-96 12724937-1 2003 Serotonin (5HT1A) is a chemical mediator of inflammation and the largest single neurotransmitter system of the brain. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 11-16 12468035-12 2002 These findings showed that nNOS immunoreactivity and NADPHd activity increased immediately after 5HT depletion evidencing a close functional interaction between nitrergic and serotoninergic systems. Serotonin 97-100 nitric oxide synthase 1 Homo sapiens 27-31 12486144-3 2002 Nucleotide sequence analysis of mouse forebrain neocortical 5-HT2C mRNA isoforms revealed that editing at these two sites is regulated in a serotonin-dependent manner. Serotonin 140-149 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 60-66 12486144-5 2002 This results in an increased expression of 5-HT2C mRNA isoforms encoding receptors with higher sensitivity to serotonin. Serotonin 110-119 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 43-49 10222050-7 1999 UGT1A6 could play an important role in the glucuronidation of 5-hydroxytryptamine in vivo, therefore terminating the actions of the neurotransmitter. Serotonin 62-81 UDP glucuronosyltransferase family 1 member A6 Homo sapiens 0-6 11249962-4 2001 To address these questions, we expressed the Drosophila serotonin (5HT) transporter (dSERT) in Xenopus oocytes and measured both substrate-elicited ion flux and 5HT flux at various temperatures and substrate concentrations. Serotonin 67-70 Serotonin transporter Drosophila melanogaster 85-90 10498288-11 1999 Microinjection of the 5-HT1A receptor agonist (+/-)-8-hydroxy-dipropylaminotetralin (8-OH-DPAT; 7.5 nmol, 50 nl) into the DRN led to a long-lasting reduction of the release rate of serotonin in the locus coeruleus. Serotonin 181-190 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-28 10498288-15 1999 The neuronal serotonin release in the locus coeruleus is modulated by 5-HT1A receptors lying within the DRN. Serotonin 13-22 5-hydroxytryptamine receptor 1A Rattus norvegicus 70-76 11249962-8 2001 The difference in half-maximal 5HT concentration necessary to mediate ion flux and 5HT flux occurs at submicromolar 5HT concentrations suggesting that the relative participation of dSERT in ion flux and 5HT flux will be determined by the synaptic 5HT concentration. Serotonin 31-34 Serotonin transporter Drosophila melanogaster 181-186 11249962-8 2001 The difference in half-maximal 5HT concentration necessary to mediate ion flux and 5HT flux occurs at submicromolar 5HT concentrations suggesting that the relative participation of dSERT in ion flux and 5HT flux will be determined by the synaptic 5HT concentration. Serotonin 83-86 Serotonin transporter Drosophila melanogaster 181-186 12413835-1 2002 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity. Serotonin 74-83 5-hydroxytryptamine receptor 1A Rattus norvegicus 84-91 11249962-8 2001 The difference in half-maximal 5HT concentration necessary to mediate ion flux and 5HT flux occurs at submicromolar 5HT concentrations suggesting that the relative participation of dSERT in ion flux and 5HT flux will be determined by the synaptic 5HT concentration. Serotonin 83-86 Serotonin transporter Drosophila melanogaster 181-186 12413835-1 2002 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity. Serotonin 74-83 5-hydroxytryptamine receptor 2A Rattus norvegicus 93-100 11249962-8 2001 The difference in half-maximal 5HT concentration necessary to mediate ion flux and 5HT flux occurs at submicromolar 5HT concentrations suggesting that the relative participation of dSERT in ion flux and 5HT flux will be determined by the synaptic 5HT concentration. Serotonin 83-86 Serotonin transporter Drosophila melanogaster 181-186 11249962-8 2001 The difference in half-maximal 5HT concentration necessary to mediate ion flux and 5HT flux occurs at submicromolar 5HT concentrations suggesting that the relative participation of dSERT in ion flux and 5HT flux will be determined by the synaptic 5HT concentration. Serotonin 83-86 Serotonin transporter Drosophila melanogaster 181-186 11667949-0 2001 Inability of serotonin to activate the c-Jun N-terminal kinase and p38 kinase pathways in rat aortic vascular smooth muscle cells. Serotonin 13-22 mitogen activated protein kinase 14 Rattus norvegicus 67-70 12617810-3 2002 In order to characterize the organization of serotonergic neurons in the zebrafish we cloned two cDNAs encoding distinct forms of tryptophan hydroxylase (Tph), the rate-limiting enzyme in serotonin synthesis. Serotonin 188-197 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a Danio rerio 130-152 12617810-3 2002 In order to characterize the organization of serotonergic neurons in the zebrafish we cloned two cDNAs encoding distinct forms of tryptophan hydroxylase (Tph), the rate-limiting enzyme in serotonin synthesis. Serotonin 188-197 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a Danio rerio 154-157 10194433-7 1999 Furthermore, stimulation of human platelets via the FcepsilonRI induced the release of serotonin and RANTES (Regulated on Activation, Normal T Expressed, and presumably Secreted). Serotonin 87-96 Fc epsilon receptor Ia Homo sapiens 52-63 11408772-2 2001 We reported that human platelets via the FcepsilonRI induced the release of the chemical mediator serotonin and the chemokine RANTES (regulated upon activation, normal T expressed and presumably secreted), but the biological implication of human platelets in type I allergy has not yet been understood clearly. Serotonin 98-107 Fc epsilon receptor Ia Homo sapiens 41-52 12617810-12 2002 The co-expression of tphD1, tphD2 and 5-HT in the zebrafish diencephalon appears in striking contrast to the situation in mammals, where diencephalic serotonin results from re-uptake rather than from local production. Serotonin 150-159 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a Danio rerio 21-26 12421646-4 2002 We found that ghrelin did not modify dopamine or norepinephrine release, but inhibited serotonin release. Serotonin 87-96 ghrelin and obestatin prepropeptide Rattus norvegicus 14-21 11191631-2 2000 Concentration-response curves were obtained following the exposure of the oocytes to varying concentrations of either ALEPH-2 or 5-hydroxytryptamine (5-HT) for 10 s. ALEPH-2 is a partial agonist on the 5-HT2A receptor with a similar potency to 5-HT. Serotonin 129-148 5-hydroxytryptamine receptor 2A Rattus norvegicus 202-208 12421646-6 2002 We conclude that the appetite-stimulating activity of ghrelin could be mediated by inhibited serotonin release, while the anorectic effects of amylin could involve inhibited release of dopamine in the hypothalamus. Serotonin 93-102 ghrelin and obestatin prepropeptide Rattus norvegicus 54-61 11167306-9 2000 Improved resistance to the fatiguing effects of the serotonin agonist suggests desensitization of central serotonin receptors, probably the 5-HT1A receptors. Serotonin 52-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 140-146 12391293-4 2002 Functional experiments in human and rat show that inhibitors of Src (Lavendustin A, PP2) but not inactive compounds (Lavendustin B, PP3) induce a pronounced relaxation of coronary or aortic smooth muscle precontracted with 5-hydroxytriptamine, phenylephrine, or Angiotensin II. Serotonin 223-242 neuropeptide Y receptor Y6 (pseudogene) Homo sapiens 84-87 12388591-5 2002 In extracellular recordings, all three agonists increased the firing rate of serotonin neurons; the excitatory effects of histamine and orexin A were occluded by previous application of phenylephrine, suggesting that all three systems act via common effector mechanisms. Serotonin 77-86 hypocretin Mus musculus 136-144 12196560-4 2002 In 5-HT3A-expressing VIP/CCK interneurons, serotonin induced fast membrane potential depolarizations by activating an inward current that was blocked by the selective 5-HT3R antagonist tropisetron. Serotonin 43-52 5-hydroxytryptamine receptor 3A Rattus norvegicus 167-173 11229360-1 2000 Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression. Serotonin 77-86 monoamine oxidase A Mus musculus 18-37 12354282-6 2002 COS-7 cells expressing SER-2 bind [3H]LSD in the low nM range and exhibit Kis for tyramine, octopamine and serotonin of 0.07, 2, and 13.7 micro m, respectively. Serotonin 107-116 jagged canonical Notch ligand 2 Homo sapiens 23-28 11229360-1 2000 Mice deficient in monoamine oxidase A (MAO A) have increased brain levels of serotonin (5-HT) and norepinephrine and show enhanced aggression. Serotonin 77-86 monoamine oxidase A Mus musculus 39-44 10987819-8 2000 These data show that pineal AP-1 binding activity, which results from Fra-2 expression, can be modulated by light and serotonin through the suprachiasmatic nucleus according to a "phase dependence" that is characteristic of the rhythm of clock sensitivity to both zeitgebers. Serotonin 118-127 FOS like 2, AP-1 transcription factor subunit Rattus norvegicus 70-75 12112397-1 2002 The 5-hydroxytryptamine (5-HT; serotonin)-6 receptor (5-HT6R) is a putative target of atypical antipsychotic drugs and its mRNA expression is altered in schizophrenia. Serotonin 4-23 5-hydroxytryptamine receptor 6 Homo sapiens 54-60 12055265-8 2002 PECAM-1(-/-) bone marrow mast cells showed enhanced dense granule serotonin release after Fc epsilon RI cross-linking in vitro. Serotonin 66-75 platelet/endothelial cell adhesion molecule 1 Mus musculus 0-7 10997729-8 2000 A significant, non-parallel shift in the dose-response curve of serotonergic neurons to the serotonin-1A (5-HT1A) agonist 8-OH-DPAT occurred over the 21 days of treatment with fluoxetine, indicating a desensitization of the 5-HT1A receptor during this period. Serotonin 92-101 5-hydroxytryptamine receptor 1A Rattus norvegicus 106-112 12105110-1 2002 Astrocytes and serotoninergic neurons play a role in central nervous system (CNS) development, probably through serotonin (5HT) stimulation of the glial 5HT(1A) receptor. Serotonin 15-24 5-hydroxytryptamine receptor 1A Rattus norvegicus 153-159 11001177-0 2000 Depressive behavior and alterations in receptors for dopamine and 5-hydroxytryptamine in the brain of the senescence accelerated mouse (SAM)-P10. Serotonin 66-85 S100 calcium binding protein A10 (calpactin) Mus musculus 141-144 12105110-1 2002 Astrocytes and serotoninergic neurons play a role in central nervous system (CNS) development, probably through serotonin (5HT) stimulation of the glial 5HT(1A) receptor. Serotonin 123-126 5-hydroxytryptamine receptor 1A Rattus norvegicus 153-159 12041875-4 2002 A lowered serotonin release in the lateral hypothalamus characterized the rats that consumed the BCAA-based solution. Serotonin 10-19 AT-rich interaction domain 4B Rattus norvegicus 97-101 12004196-2 2002 The effect of serotonin on food intake is believed to be primarily mediated via 5-HT(1A) and 5-HT(2C) receptors, which both are expressed in hypothalamic regions implicated in regulation of feeding behavior. Serotonin 14-23 5-hydroxytryptamine receptor 1A Rattus norvegicus 80-87 12004196-6 2002 The results suggest that serotonin via postsynaptic 5-HT(1A) receptors affects the release of peptides regulating food intake. Serotonin 25-34 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-59 11891878-1 2002 Activation of serotonin (5-hydroxytryptamine; 5HT) receptors of the 2A subtype (5HT2A) in the intermediate portion of the medial nucleus tractus solitarius (mNTS) produces marked hypotension and bradycardia. Serotonin 14-23 5-hydroxytryptamine receptor 2A Rattus norvegicus 80-85 11891878-1 2002 Activation of serotonin (5-hydroxytryptamine; 5HT) receptors of the 2A subtype (5HT2A) in the intermediate portion of the medial nucleus tractus solitarius (mNTS) produces marked hypotension and bradycardia. Serotonin 25-44 5-hydroxytryptamine receptor 2A Rattus norvegicus 80-85 11956970-2 2002 This investigation of central serotonin neurotransmission, specifically the serotonin 1B (5HT1B) receptor gene and its role in both regulating alcohol consumption and developing alcohol dependence revealed overrepresentation of the C allele of the 861G > C polymorphism of 5HT1B in alcoholics with inactive ALDH2, compared with its frequency in nonalcoholic controls. Serotonin 30-39 aldehyde dehydrogenase 2 family member Homo sapiens 310-315 11814396-3 2002 Some of this work can be informed by pharmacologic challenge studies, which exploit the role of serotonin in regulating rCBF. Serotonin 96-105 CCAAT/enhancer binding protein zeta Rattus norvegicus 120-124 11906203-5 2002 We have shown that serotonin neurons in nonhuman primates contain estrogen receptor beta and progestin receptors. Serotonin 19-28 estrogen receptor 2 Homo sapiens 66-88 12403357-3 2002 Efficient coligation of PIR-B with FcepsilonRI inhibited IgE-induced mast cell activation and serotonin release. Serotonin 94-103 Fc epsilon receptor Ia Homo sapiens 35-46 11823058-2 2002 Together with overlapping expression patterns of dopamine and serotonin receptors this suggests a potential of CB1 to modulate the function of the dopamine and serotonin system. Serotonin 62-71 cannabinoid receptor 1 (brain) Mus musculus 111-114 12043045-7 2002 TRH remains under a constant inhibition by serotonin and reduced intracerebral serotonin concentration seen in depression will lead to increased TRH concentration in brain tissue. Serotonin 43-52 thyrotropin releasing hormone Homo sapiens 0-3 11743138-1 2001 Long-term potentiation of sympathetic ganglia (gLTP), a unique form of synaptic plasticity, is serotonin dependent and can be blocked with 5-HT3 receptor antagonists. Serotonin 95-104 5-hydroxytryptamine receptor 3A Rattus norvegicus 139-153 11745679-7 2001 Serotonin-producing endocrine tumours (ileal and appendiceal carcinoids) expressed predominantly VMAT1, while histamine-producing endocrine tumours (gastric carcinoids) expressed VMAT2 almost exclusively. Serotonin 0-9 solute carrier family 18 member A1 Homo sapiens 97-102 11746359-0 2001 Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A. Serotonin 9-18 monoamine oxidase A Mus musculus 70-89 11746359-1 2001 The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on the activity of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, and on the levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in the midbrain, hypothalamus, hippocampus, striatum, amygdala, and frontal cortex was studied. Serotonin 170-179 monoamine oxidase A Mus musculus 42-61 11746359-1 2001 The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on the activity of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, and on the levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in the midbrain, hypothalamus, hippocampus, striatum, amygdala, and frontal cortex was studied. Serotonin 170-179 monoamine oxidase A Mus musculus 63-68 11746359-1 2001 The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg8 mice on the activity of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, and on the levels of 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) in the midbrain, hypothalamus, hippocampus, striatum, amygdala, and frontal cortex was studied. Serotonin 181-185 monoamine oxidase A Mus musculus 63-68 11443056-5 2001 Other agonists including norepinephrine, serotonin, histamine, and endothelin-1 (ET-1) also stimulated RhoA, albeit to lesser extents than U-46619. Serotonin 41-50 transforming protein RhoA Oryctolagus cuniculus 103-107 11443529-1 2001 The promoter polymorphism of the serotonin transporter gene (HTT, locus SLC6A4) is of special interest in autism given the well-replicated platelet hyperserotonemia of autism, treatment effects of serotonin reuptake inhibitors, and the role of serotonin in limbic functioning and neurodevelopment. Serotonin 33-42 huntingtin Homo sapiens 61-64 11418278-0 2001 Effects of selective 5-HT1A receptor antagonists on regional serotonin synthesis in the rat brain: an autoradiographic study with alpha-[14C]methyl-L-tryptophan. Serotonin 61-70 5-hydroxytryptamine receptor 1A Rattus norvegicus 21-27 11408032-8 2001 Serotonin acting through 5-HT3 receptors might play a significant role in the pathophysiology of tardive dyskinesia, and 5-HT3 receptor ligands can be exploited as novel therapeutic agents for the treatment of tardive dyskinesia. Serotonin 0-9 5-hydroxytryptamine receptor 3A Rattus norvegicus 25-39 11259568-4 2001 Therefore, we used whole-cell recording techniques in the in vitro brain slices to examine the effects of serotonin on neurons of the anterodorsal nucleus of the thalamus (ADn). Serotonin 106-115 complement factor D Homo sapiens 172-175 11259568-14 2001 These results identify the receptor mediating the serotonin-induced membrane depolarization in the ADn as the 5-HT7 subtype. Serotonin 50-59 complement factor D Homo sapiens 99-102 11260059-0 2001 Myristoylated alanine-rich C kinase substrate phosphorylation is involved in thrombin-induced serotonin release from platelets. Serotonin 94-103 myristoylated alanine rich protein kinase C substrate Homo sapiens 0-45 11166334-2 2001 In this study we investigated interactions between bradykinin, serotonin, histamine, prostaglandin and acid pH in stimulating the release of substance P (SP), calcitonin gene-related peptide (CGRP) and prostaglandin E(2) (PGE(2)) from isolated flaps of rat back skin using enzyme immunoassays. Serotonin 63-72 calcitonin-related polypeptide alpha Rattus norvegicus 159-190 11233991-3 2001 MAO A prefers 5-hydroxytryptamine (serotonin), and MAO B prefers phenylethylamine (PEA) as substrate. Serotonin 14-33 monoamine oxidase A Mus musculus 0-5 11233991-3 2001 MAO A prefers 5-hydroxytryptamine (serotonin), and MAO B prefers phenylethylamine (PEA) as substrate. Serotonin 35-44 monoamine oxidase A Mus musculus 0-5 11157075-2 2001 In MAOA knock-out mice, inhibiting serotonin synthesis during development can prevent abnormal segregation of axons in the retinogeniculate and somatosensory thalamocortical systems. Serotonin 35-44 monoamine oxidase A Mus musculus 3-7 10081922-0 1999 Serotonin levels are abnormally elevated in the fetus of the monoamine oxidase-A-deficient transgenic mouse. Serotonin 0-9 monoamine oxidase A Mus musculus 61-80 9930750-6 1999 GTPCH mRNA levels were also lower in hph-1 female than in wild-type female mice, again with the greatest reduction occurring in serotonin neurons. Serotonin 128-137 hyperphenylalaninemia 1 Mus musculus 37-42 10449982-7 1999 Stimulation of the adenylyl cyclase pathway by activation of 5-HT(1A) or 5-HT(4) receptors may be one mechanism by which serotonin regulates IGF-I synthesis in developing craniofacial mesenchymal cells. Serotonin 121-130 insulin-like growth factor 1 Mus musculus 141-146 10094235-0 1999 Serotonin and learned helplessness: a regional study of 5-HT1A, 5-HT2A receptors and the serotonin transport site in rat brain. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 56-62 10709190-3 1999 In all brain structures Ache and MAO (substrate 5-hydroxytryptamine) activities were not influenced by DSIP. Serotonin 48-67 monoamine oxidase A Rattus norvegicus 33-36 10922998-1 2000 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]) has been shown to induce chloride secretion through a nonadrenergic/noncholinergic neural pathway, mediated by a 5-HT(3) receptor. Serotonin 12-21 5-hydroxytryptamine receptor 3A Rattus norvegicus 164-180 11462981-3 2001 The design was based on coupling structural moieties related to inhibition of serotonin reuptake, such as gamma-phenoxypropylamines, to arylpiperazines, typical 5-HT1A ligands. Serotonin 78-87 5-hydroxytryptamine receptor 1A Rattus norvegicus 161-167 11158630-0 2001 Brain serotonin dysfunction accounts for aggression in male mice lacking neuronal nitric oxide synthase. Serotonin 6-15 nitric oxide synthase 1, neuronal Mus musculus 73-103 11158630-6 2001 We now demonstrate that the excessive aggressiveness and impulsiveness of nNOS knockout mice is caused by selective decrements in serotonin (5-HT) turnover and deficient 5-HT(1A) and 5-HT(1B) receptor function in brain regions regulating emotion. Serotonin 130-139 nitric oxide synthase 1, neuronal Mus musculus 74-78 10922998-1 2000 BACKGROUND: Serotonin (5-hydroxytryptamine [5-HT]) has been shown to induce chloride secretion through a nonadrenergic/noncholinergic neural pathway, mediated by a 5-HT(3) receptor. Serotonin 23-42 5-hydroxytryptamine receptor 3A Rattus norvegicus 164-180 10799660-1 2000 Phentermine was shown in the 1970s to inhibit the metabolism of serotonin by monoamine oxidase (MAO), but never was labeled as an MAO inhibitor; hence, it was widely used in combination with fenfluramine, and continues to be used, in violation of their labels, with other serotonin uptake blockers. Serotonin 64-73 monoamine oxidase A Rattus norvegicus 77-94 11274793-0 2001 Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain. Serotonin 38-47 prostaglandin E receptor 3 Rattus norvegicus 14-17 11274793-3 2001 In the present study, a double immunofluorescence technique with an antibody to EP3 receptor and antibodies to markers for monoamine neurons was employed to examine the expression of the receptor in serotonin and catecholamine neurons, and to reveal the distribution of the receptor-expressing monoamine neurons in the rat brain. Serotonin 199-208 prostaglandin E receptor 3 Rattus norvegicus 80-83 10799660-1 2000 Phentermine was shown in the 1970s to inhibit the metabolism of serotonin by monoamine oxidase (MAO), but never was labeled as an MAO inhibitor; hence, it was widely used in combination with fenfluramine, and continues to be used, in violation of their labels, with other serotonin uptake blockers. Serotonin 64-73 monoamine oxidase A Rattus norvegicus 96-99 10799660-4 2000 Phentermine inhibited serotonin-metabolizing (MAO-A) activity in all three tissues with K(i) values of 85-88 microM. Serotonin 22-31 monoamine oxidase A Rattus norvegicus 46-51 11109001-1 2000 In brainstem-spinal cord preparations of neonatal control C3H and transgenic Tg8 mice where deletion of the gene encoding monoamine oxidase-A results in serotonin (5-hydroxytryptamine (HT)) excess, whole cell recordings of identified phrenic motoneurons (Phr Mns) were performed to study the modulation of their activity by 5-HT. Serotonin 153-162 monoamine oxidase A Mus musculus 122-141 10848821-8 2000 Using [14C]-serotonin release assays, the antibodies developed in the three patients and exhibiting the strongest ability to activate platelets with heparin were those having the highest affinity to H-PF4. Serotonin 12-21 platelet factor 4 Homo sapiens 201-204 11109001-1 2000 In brainstem-spinal cord preparations of neonatal control C3H and transgenic Tg8 mice where deletion of the gene encoding monoamine oxidase-A results in serotonin (5-hydroxytryptamine (HT)) excess, whole cell recordings of identified phrenic motoneurons (Phr Mns) were performed to study the modulation of their activity by 5-HT. Serotonin 164-183 monoamine oxidase A Mus musculus 122-141 11109001-1 2000 In brainstem-spinal cord preparations of neonatal control C3H and transgenic Tg8 mice where deletion of the gene encoding monoamine oxidase-A results in serotonin (5-hydroxytryptamine (HT)) excess, whole cell recordings of identified phrenic motoneurons (Phr Mns) were performed to study the modulation of their activity by 5-HT. Serotonin 185-187 monoamine oxidase A Mus musculus 122-141 11071365-9 2000 The 5-HT1A receptor agonist 8-OH-DPAT (0.01 to 1 microM) and the 5-HT1B receptor agonist CGS-12066A (0.01 to 1 microM) inhibited the electrically stimulated [3H]serotonin and [3H]GABA release. Serotonin 161-170 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10 10792366-11 2000 In wild-type ovalbumin-immunized mice, bronchial hyperresponsiveness to aerosolized 5-hydroxytryptamine was observed following a 3-day antigen challenge, which was significantly greater in CD23-/- ovalbumin-immunized mice. Serotonin 84-103 Fc receptor, IgE, low affinity II, alpha polypeptide Mus musculus 189-193 10800921-1 2000 The aim of this study was to investigate if p-chloroamphetamine (PCA), which is neurotoxic to serotonin (5-HT) nerve terminals, was able to induce, like 3,4-methylenedioxymethamphetamine, a region-specific regulation of 5-HT1A receptor mRNA expression. Serotonin 94-103 5-hydroxytryptamine receptor 1A Rattus norvegicus 220-226 11065183-5 2000 The results obtained using our experimental model in rats do not confirm the hypothesis of other authors who suggest that the Hex responds secondary to increases or decreases of serotonin turnover, and could be a biological test to monitor the serotonin status in psychiatric patients. Serotonin 178-187 hematopoietically expressed homeobox Rattus norvegicus 126-129 10688905-1 2000 In this paper, we present evidence that activation of 5-hydroxytryptamine 2B (5-HT2B) receptors by serotonin (5-HT) leads to cell-cycle progression through retinoblastoma protein hyperphosphorylation and through activation of both cyclin D1/cdk4 and cyclin E/cdk2 kinases by a mechanism that depends on induction of cyclin D1 and cyclin E protein levels. Serotonin 99-108 cyclin D1 Homo sapiens 231-240 11065183-5 2000 The results obtained using our experimental model in rats do not confirm the hypothesis of other authors who suggest that the Hex responds secondary to increases or decreases of serotonin turnover, and could be a biological test to monitor the serotonin status in psychiatric patients. Serotonin 244-253 hematopoietically expressed homeobox Rattus norvegicus 126-129 10688905-1 2000 In this paper, we present evidence that activation of 5-hydroxytryptamine 2B (5-HT2B) receptors by serotonin (5-HT) leads to cell-cycle progression through retinoblastoma protein hyperphosphorylation and through activation of both cyclin D1/cdk4 and cyclin E/cdk2 kinases by a mechanism that depends on induction of cyclin D1 and cyclin E protein levels. Serotonin 99-108 cyclin dependent kinase 4 Homo sapiens 241-245 10688905-1 2000 In this paper, we present evidence that activation of 5-hydroxytryptamine 2B (5-HT2B) receptors by serotonin (5-HT) leads to cell-cycle progression through retinoblastoma protein hyperphosphorylation and through activation of both cyclin D1/cdk4 and cyclin E/cdk2 kinases by a mechanism that depends on induction of cyclin D1 and cyclin E protein levels. Serotonin 99-108 cyclin dependent kinase 2 Homo sapiens 259-263 10940905-7 2000 The physical association between SIRPbeta1 and KARAP/DAP-12 results in the functional coupling of SIRPbeta1 engagement to the recruitment of the protein tyrosine kinase Syk and to serotonin release in RBL cell transfectants. Serotonin 180-189 transmembrane immune signaling adaptor Tyrobp Rattus norvegicus 47-52 10688905-1 2000 In this paper, we present evidence that activation of 5-hydroxytryptamine 2B (5-HT2B) receptors by serotonin (5-HT) leads to cell-cycle progression through retinoblastoma protein hyperphosphorylation and through activation of both cyclin D1/cdk4 and cyclin E/cdk2 kinases by a mechanism that depends on induction of cyclin D1 and cyclin E protein levels. Serotonin 99-108 cyclin D1 Homo sapiens 316-325 10940905-7 2000 The physical association between SIRPbeta1 and KARAP/DAP-12 results in the functional coupling of SIRPbeta1 engagement to the recruitment of the protein tyrosine kinase Syk and to serotonin release in RBL cell transfectants. Serotonin 180-189 transmembrane immune signaling adaptor Tyrobp Rattus norvegicus 53-59 10710124-0 2000 5-hydroxytryptamine stimulates phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures. Serotonin 0-19 erythrocyte membrane protein band 4.2 Bos taurus 54-57 10915900-1 2000 Prior work has established that hypoglossal motoneurons (HMs) change postnatally in their response to serotonin (5-HT), in part as a result of a decline in expression of 5-HT(1A) receptors. Serotonin 102-111 5-hydroxytryptamine receptor 1A Rattus norvegicus 170-177 10710124-1 2000 5-Hydroxytryptamine (5-HT) is sequestered and released by endothelial cells, acts as an endothelial cell mitogen, promotes the release of nitric oxide (NO), and has been associated with the p44/p42 mitogen-activated protein kinase (MAPK) cascade. Serotonin 0-19 erythrocyte membrane protein band 4.2 Bos taurus 194-197 10710124-1 2000 5-Hydroxytryptamine (5-HT) is sequestered and released by endothelial cells, acts as an endothelial cell mitogen, promotes the release of nitric oxide (NO), and has been associated with the p44/p42 mitogen-activated protein kinase (MAPK) cascade. Serotonin 21-25 erythrocyte membrane protein band 4.2 Bos taurus 194-197 10876026-1 2000 This laboratory previously showed that in utero ethanol exposure severely impairs the development of the cell bodies and projections of serotonin (5-HT) neurons, and that maternal treatment with a 5-HT(1A) agonist prevents many of these abnormalities. Serotonin 136-145 5-hydroxytryptamine receptor 1A Rattus norvegicus 197-204 10808528-5 2000 The data suggest that the decrease in the cortical 5-HT2A receptors is the main consequence of impairing effect of hypothyroidism on serotonin neurotransmission. Serotonin 133-142 5-hydroxytryptamine receptor 2A Rattus norvegicus 51-57 10839959-1 2000 BACKGROUND: The chloride secretory response to serotonin (5-HT) has nonneural and neural mechanisms, the latter mediated through a 5-HT(3) receptor. Serotonin 47-56 5-hydroxytryptamine receptor 3A Rattus norvegicus 131-147 10648401-0 2000 Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation. Serotonin 163-172 myristoylated alanine rich protein kinase C substrate Homo sapiens 96-102 10867965-3 2000 OBJECTIVES: To characterize the intrinsic activity of serotonin (5-HT)1A agonists by examining the effects of an irreversible antagonist on their ability to produce 5-HT1A receptor-mediated responses. Serotonin 54-63 5-hydroxytryptamine receptor 1A Rattus norvegicus 165-171 10757529-3 2000 Depletion of neocortical serotonin or catecholamine afferents with selective neurotoxins resulted in a permanent alteration of the dendritic arborization of calretinin-containing interneurons, and a transient delay of parvalbumin and calbindin expression in a number of cortical neurones during the second postnatal week. Serotonin 25-34 calbindin 2 Mus musculus 157-167 10648401-0 2000 Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation. Serotonin 163-172 myristoylated alanine rich protein kinase C substrate Homo sapiens 106-112 10710369-8 2000 Serotonin stimulation led to significant increases in cGMP and in the phosphorylation of HSP20, which were inhibited by pretreatment with L-NMMA. Serotonin 0-9 heat shock protein beta-6 Bos taurus 89-94 10391482-6 1999 In a second series of experiments, the effects of a combined administration of dopamine D1 and serotonin 5-HT1A or 5-HT2A/2C agonists were studied. Serotonin 95-104 5-hydroxytryptamine receptor 1A Rattus norvegicus 105-111 10672864-11 2000 These results indicate that serotonin-induced coronary spasm is mediated primarily by 5-HT2A receptor in our porcine model, although the 5-HT2A receptor was not up-regulated, suggesting that alteration in the signal-transduction pathway for vascular smooth muscle contraction beyond the 5-HT2A receptor plays a primary role in the pathogenesis of coronary spasm in our porcine model. Serotonin 28-37 5-hydroxytryptamine receptor 2A Sus scrofa 86-101 10648401-0 2000 Platelet secretion induced by phorbol esters stimulation is mediated through phosphorylation of MARCKS: a MARCKS-derived peptide blocks MARCKS phosphorylation and serotonin release without affecting pleckstrin phosphorylation. Serotonin 163-172 myristoylated alanine rich protein kinase C substrate Homo sapiens 106-112 10672865-8 2000 In this study, we report that RAR gamma subgroup-specific agonists are the most potent inhibitors of serum and serotonin VSMC proliferation, as compared with other RAR pan-agonists and naturally occurring retinoids tested. Serotonin 111-120 retinoic acid receptor gamma Homo sapiens 30-39 10648401-6 2000 MARCKS phosphorylation and serotonin release from permeabilized platelets have the same time course and were blocked by a peptide (MPSD) with the amino acid sequence corresponding to the phosphorylation site domain of MARCKS. Serotonin 27-36 myristoylated alanine rich protein kinase C substrate Homo sapiens 218-224 10672865-8 2000 In this study, we report that RAR gamma subgroup-specific agonists are the most potent inhibitors of serum and serotonin VSMC proliferation, as compared with other RAR pan-agonists and naturally occurring retinoids tested. Serotonin 111-120 retinoic acid receptor gamma Homo sapiens 30-33 10888271-5 2000 We now demonstrate that, in addition to histamine, melatonin and the biogenic amines dopamine, serotonin and noradrenaline bind to P450 isozymes and to cytochrome C. Serotonin 95-104 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 131-135 11268389-6 2000 The HPA-activating activity of IL-1 is associated with increases in the apparent release of brain noradrenaline (NA) and serotonin (5-HT), but not dopamine, as well as with increased brain tryptophan. Serotonin 121-130 interleukin 1 complex Mus musculus 31-35 11268389-6 2000 The HPA-activating activity of IL-1 is associated with increases in the apparent release of brain noradrenaline (NA) and serotonin (5-HT), but not dopamine, as well as with increased brain tryptophan. Serotonin 132-136 interleukin 1 complex Mus musculus 31-35 10391482-7 1999 The goal of the last series of experiments was to determine the effects of a combined administration of the dopamine D2 agonist and either serotonin 5-HT1A or 5-HT2A/2C agonists. Serotonin 139-148 5-hydroxytryptamine receptor 1A Rattus norvegicus 149-155 10606783-2 2000 Serotonin (5-HT(3))-receptor antagonists are used to treat vomiting in intravenous or oral administration but not suppository form. Serotonin 0-9 5-hydroxytryptamine receptor 3A Oryctolagus cuniculus 11-28 10025679-9 1999 These results indicate that both 5-HT1A and 5-HT1B/1D receptors, which function in the rat as inhibitory somatodendritic and nerve terminal autoreceptors, independently regulate hippocampal 5-HT synthesis and must be simultaneously blocked to prevent the inhibition of 5-HT synthesis by selective serotonin reuptake inhibitors which increase 5-HT availability at both nerve terminals in hippocampus and 5-HT cell bodies in the raphe nuclei. Serotonin 297-306 5-hydroxytryptamine receptor 1A Rattus norvegicus 33-39 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 36-45 monoamine oxidase A Rattus norvegicus 104-121 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 36-45 monoamine oxidase A Rattus norvegicus 123-126 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 184-193 monoamine oxidase A Rattus norvegicus 104-121 10548268-1 1999 Evidence for a role of dopamine and serotonin in the control of ethanol intake in animals suggests that monoamine oxidase (MAO) inhibitors, which increase the synaptic availability of serotonin and dopamine by blocking their metabolism, might have efficacy in the treatment of alcohol dependence. Serotonin 184-193 monoamine oxidase A Rattus norvegicus 123-126 10812456-5 2000 At the hypothalamic level, thyrotropin releasing hormone (TRH) is controlled by the monoamonergic system and by serotonin. Serotonin 112-121 thyrotropin releasing hormone Homo sapiens 58-61 10584065-3 1999 The rat aromatic L-amino acid decarboxylase (AADC; EC(4.1.1.28)) catalyzes the synthesis of two important neurotransmitters: dopamine and serotonin. Serotonin 138-147 dopa decarboxylase Rattus norvegicus 8-43 10584065-3 1999 The rat aromatic L-amino acid decarboxylase (AADC; EC(4.1.1.28)) catalyzes the synthesis of two important neurotransmitters: dopamine and serotonin. Serotonin 138-147 dopa decarboxylase Rattus norvegicus 45-49 9838121-7 1998 Moreover, dopamine- and serotonin-degrading MAO activity has also been found in LC neurons. Serotonin 24-33 monoamine oxidase A Rattus norvegicus 44-47 9838121-8 1998 Therefore, our results indicate that MAO activity is localized within noradrenergic neurons in the LC and is likely involved in the degradation of dopamine that is endogenously synthesized, and also in the elimination of serotonin that is produced from exogenous precursors. Serotonin 221-230 monoamine oxidase A Rattus norvegicus 37-40 10504491-7 1999 The MAO substrate [14C]serotonin was transported into mesangial cells by a saturable uptake system (Vmax 310 +/- 36 pmol/30 min/mg protein; Km 5.9 +/- 1.4 microM) displaying the pharmacological properties of a serotonin transporter. Serotonin 23-32 monoamine oxidase A Rattus norvegicus 4-7 9928006-2 1998 PACAP(1-27) and PACAP(6-27) stimulated [3H]serotonin release with low potency (ED50: 2 x 10(-6) M) but high efficacy. Serotonin 43-52 adenylate cyclase activating polypeptide 1 Rattus norvegicus 0-5 11125474-7 2000 C5a activates local mast cells to release serotonin (5-HT) and TNF alpha to induce endothelial ICAM-1 and VCAM-1, leading to T cell recruitment. Serotonin 42-51 intercellular adhesion molecule 1 Mus musculus 95-101 9928006-2 1998 PACAP(1-27) and PACAP(6-27) stimulated [3H]serotonin release with low potency (ED50: 2 x 10(-6) M) but high efficacy. Serotonin 43-52 adenylate cyclase activating polypeptide 1 Rattus norvegicus 16-21 10511460-5 1999 By contrast, BMCMC grown in SCF-containing medium or freshly isolated peritoneal mast cells exhibited significant 3H-hydroxytrypamine (5-HT) release in response to PACAP peptides or VIP. Serotonin 135-139 adenylate cyclase activating polypeptide 1 Homo sapiens 164-169 10526335-5 1999 Here we demonstrate that protein interactions involving the GluR2/3 C terminus are important for serotonin-induced activation of silent synapses in the spinal cord. Serotonin 97-106 glutamate ionotropic receptor AMPA type subunit 2 Homo sapiens 60-65 10473967-4 1999 RESULTS: Endocrine cells forming diffuse, linear, and micronodular hyperplasia in CAG and ZES, as well as oxyntic microcarcinoids expressed both VMAT2 and chromogranin A (CgA) but neither VMAT1 nor serotonin. Serotonin 198-207 solute carrier family 18 member A2 Homo sapiens 145-150 10574568-3 1999 Previous work from this laboratory demonstrated that systemic administrations of the serotonin agonist quipazine mimic the effects of light on the circadian system of rats, i.e. they induce photic-like phase shifts of the circadian activity rhythm as well as c-Fos expression in the SCN. Serotonin 85-94 steroid sulfatase Rattus norvegicus 256-260 11281992-1 1999 A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. Serotonin 158-167 monoamine oxidase A Mus musculus 113-132 10677040-0 1999 Serotonin inhibition of synaptic transmission: Galpha(0) decreases the abundance of UNC-13 at release sites. Serotonin 0-9 Phorbol ester/diacylglycerol-binding protein unc-13 Caenorhabditis elegans 84-90 10677040-4 1999 The effects of serotonin on synaptic transmission were mediated by GOA-1 (a Galpha0 subunit) and DGK-1 (a diacylglycerol [DAG] kinase), both of which act in the ventral cord motor neurons. Serotonin 15-24 Guanine nucleotide-binding protein G(o) subunit alpha Caenorhabditis elegans 67-72 9836624-1 1998 Spiperone (1) is a widely used pharmacological tool that acts as a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Serotonin 109-118 5-hydroxytryptamine receptor 2A Rattus norvegicus 119-125 9843894-6 1998 Excitatory responses could also be mimicked by the 5-hydroxytryptamine (5-HT)2A/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI; 1-10 microM) and could be blocked by the 5-HT2A/2C-receptor antagonist LY-53,857 (10 microM). Serotonin 51-70 5-hydroxytryptamine receptor 2A Rattus norvegicus 179-185 9843894-8 1998 Serotonin-inhibited cells were also inhibited by the 5-HT1A-receptor agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT; 1-10 microM; n = 7). Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 53-59 10677040-5 1999 Mutants lacking goa-1 G(alpha)0 accumulated abnormally high levels of the DAG-binding protein UNC-13 at motor neuron nerve terminals, suggesting that serotonin inhibits synaptic transmission by decreasing the abundance of UNC-13 at release sites. Serotonin 150-159 Guanine nucleotide-binding protein G(o) subunit alpha Caenorhabditis elegans 16-21 9756504-0 1998 Effect of VIP and PACAP on basal release of serotonin from isolated vascularly and luminally perfused rat duodenum. Serotonin 44-53 adenylate cyclase activating polypeptide 1 Rattus norvegicus 18-23 10384263-0 1999 5-Hydroxytryptamine inhibits P2X2 receptor channel pore mutants. Serotonin 0-19 purinergic receptor P2X, ligand gated ion channel, 2 L homeolog Xenopus laevis 29-33 9756504-1 1998 The effect of vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating peptide-38 (PACAP-38), and PACAP-27 on the release of serotonin (5-HT) into the intestinal lumen and the portal circulation was studied by using in vivo isolated vascularly and luminally perfused rat duodenum. Serotonin 148-157 adenylate cyclase activating polypeptide 1 Rattus norvegicus 121-126 9785594-1 1998 It has been proposed that the reversal of serotonin-mediated vasoconstriction accounts for the neuroprotective effect of serotonin (5-HT2) receptor blockade in focal cerebral ischemia. Serotonin 42-51 5-hydroxytryptamine receptor 2A Rattus norvegicus 121-147 10677040-5 1999 Mutants lacking goa-1 G(alpha)0 accumulated abnormally high levels of the DAG-binding protein UNC-13 at motor neuron nerve terminals, suggesting that serotonin inhibits synaptic transmission by decreasing the abundance of UNC-13 at release sites. Serotonin 150-159 Phorbol ester/diacylglycerol-binding protein unc-13 Caenorhabditis elegans 94-100 10677040-5 1999 Mutants lacking goa-1 G(alpha)0 accumulated abnormally high levels of the DAG-binding protein UNC-13 at motor neuron nerve terminals, suggesting that serotonin inhibits synaptic transmission by decreasing the abundance of UNC-13 at release sites. Serotonin 150-159 Phorbol ester/diacylglycerol-binding protein unc-13 Caenorhabditis elegans 222-228 10462131-1 1999 We have previously reported that (R)-(+)-2-amino-4-(4-fluorophenyl)-5-[1-[4-(4-fluorophenyl)-4-oxobutyl]+ ++pyrrolidin-3-yl]thiazole (NRA0045) is a novel antipsychotic agent with affinities for dopamine D4, 5-hydroxytryptamine 2A (5-HT2A) and alpha1 receptors. Serotonin 207-226 5-hydroxytryptamine receptor 2A Rattus norvegicus 231-237 10384263-7 1999 This implies that 5-hydroxytryptamine interacts with the P2X2 receptor/channel at their channel pores. Serotonin 18-37 purinergic receptor P2X, ligand gated ion channel, 2 L homeolog Xenopus laevis 57-61 9756382-1 1998 The present study has utilized the two electrode voltage-clamp technique to examine the pharmacological profile of a splice variant of the rat orthologue of the 5-hydroxytryptamine type 3A subunit (5-HT3A(b)) heterologously expressed in Xenopus laevis oocytes. Serotonin 161-180 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 198-204 10504491-9 1999 MAO activity measured in intact cells showed that after accumulation into mesangial cells, [14C]serotonin was metabolized by MAO-A. Serotonin 96-105 monoamine oxidase A Rattus norvegicus 0-3 14516531-2 1999 In this study we set out to determine whether nefazodone and paroxetine, two antidepressant drugs that interact with the brain serotonin system, produce detectable changes in synaptic dopamine in vivo in the human brain using positron emission tomography (PET) and [11C]raclopride, a dopamine D-2 receptor specific radiotracer that is sensitive to changes in synaptic dopamine. Serotonin 127-136 dopamine receptor D2 Homo sapiens 284-305 10504491-10 1999 Finally, serotonin-mediated mesangial cell proliferation was significantly increased after irreversible MAO inhibition. Serotonin 9-18 monoamine oxidase A Rattus norvegicus 104-107 10504491-11 1999 CONCLUSIONS: Our results suggest that serotonin concentration and function in glomeruli may be regulated in part by its transport into mesangial cells and degradation by MAO-A. Serotonin 38-47 monoamine oxidase A Rattus norvegicus 170-175 10404179-3 1999 To examine SERT"s response to high 5HT concentrations, we expressed Drosophila SERT (dSERT) in Xenopus oocytes and found that transport continued to increase with concentration up to 0.3 mM 5HT. Serotonin 35-38 Serotonin transporter Drosophila melanogaster 11-15 9695933-1 1998 We examined whether reductions in body fat stores and insulin resistance in Syrian hamsters induced by bromocriptine are associated with reductions in daily norepinephrine (NE) and serotonin activities as indicated by their extracellular metabolite levels in the ventromedial hypothalamus (VMH). Serotonin 181-190 insulin Mesocricetus auratus 54-61 10499366-6 1999 It is suggested that blockade of inhibitory 5-HT1A autoreceptors discloses inhibitory effects of the selective serotonin re-uptake inhibitor citalopram on male rat ejaculatory behavior mediated via stimulation of 5-HT1B receptors. Serotonin 111-120 5-hydroxytryptamine receptor 1A Rattus norvegicus 44-50 9673827-5 1998 5-Hydroxytryptamine caused hyperpolarization and cessation of spike activity in these neurons by activating inwardly rectifying K+ conductance via somatodendritic 5-HT1A receptors. Serotonin 0-19 5-hydroxytryptamine receptor 1A Rattus norvegicus 163-169 9673827-11 1998 5-Hydroxytryptamine regulates serotonergic neuronal activity of the caudal raphe by decreasing spontaneous activity via somatodendritic 5-HT1A receptors and by inhibiting excitatory synaptic transmission onto these neurons via presynaptic 5-HT1B receptors. Serotonin 0-19 5-hydroxytryptamine receptor 1A Rattus norvegicus 136-142 10404179-3 1999 To examine SERT"s response to high 5HT concentrations, we expressed Drosophila SERT (dSERT) in Xenopus oocytes and found that transport continued to increase with concentration up to 0.3 mM 5HT. Serotonin 35-38 Serotonin transporter Drosophila melanogaster 79-83 10404179-3 1999 To examine SERT"s response to high 5HT concentrations, we expressed Drosophila SERT (dSERT) in Xenopus oocytes and found that transport continued to increase with concentration up to 0.3 mM 5HT. Serotonin 190-193 Serotonin transporter Drosophila melanogaster 11-15 10404179-3 1999 To examine SERT"s response to high 5HT concentrations, we expressed Drosophila SERT (dSERT) in Xenopus oocytes and found that transport continued to increase with concentration up to 0.3 mM 5HT. Serotonin 190-193 Serotonin transporter Drosophila melanogaster 79-83 10404179-4 1999 As 5HT is a monovalent cation, its entry through an ion channel in SERT might explain uptake at high concentrations. Serotonin 3-6 Serotonin transporter Drosophila melanogaster 67-71 10431712-3 1999 It has been suggested that NGF may elicit hyperalgesia by inducing mast cells to release algesic agents such as serotonin (5-HT). Serotonin 112-121 nerve growth factor Rattus norvegicus 27-30 10407190-1 1999 The arylalkylamine-N-acetyltransferase (AA-NAT) expressed in the vertebrate pineal gland catalyzes the N-acetylation of the serotonin into N-acetylserotonin and is considered to be the rate limiting enzyme of the pineal melatonin synthesis. Serotonin 124-133 serotonin N-acetyltransferase Mesocricetus auratus 4-38 10217255-0 1999 Identification and role of serotonin 5-HT1A and 5-HT1B receptors in primary cultures of rat embryonic rostral raphe nucleus neurons. Serotonin 27-36 5-hydroxytryptamine receptor 1A Rattus norvegicus 37-54 10407190-1 1999 The arylalkylamine-N-acetyltransferase (AA-NAT) expressed in the vertebrate pineal gland catalyzes the N-acetylation of the serotonin into N-acetylserotonin and is considered to be the rate limiting enzyme of the pineal melatonin synthesis. Serotonin 124-133 serotonin N-acetyltransferase Mesocricetus auratus 40-46 9753102-0 1998 Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 123-129 10498989-1 1999 LPO products were measured in plasma and biogenic amines (serotonin, adrenalin, noradrenalin) in tissues of rats in different periods after hemorrhagic shock provoked by taking blood and maintenance of arterial pressure at the level of 40 mm Hg for 1 hour. Serotonin 58-67 lactoperoxidase Rattus norvegicus 0-3 9612262-1 1998 We evaluated the possibility that serotonin (5-HT) mediates defecation induced by corticotropin-releasing hormone (CRH) exogenously administered or released from the central nervous system by stress via the 5-HT3 receptor in rats. Serotonin 34-43 5-hydroxytryptamine receptor 3A Rattus norvegicus 207-221 10196105-9 1999 These results suggest that interactions between 5-HT and glutamate may mediate the beneficial effects of reducing cognitive impairment and that 5-HT antagonists, especially selective 5-HT1A antagonists, may be useful in treating AD. Serotonin 144-148 5-hydroxytryptamine receptor 1A Rattus norvegicus 183-189 10220583-0 1999 Serotonin derivative, N-(p-Coumaroyl)serotonin, isolated from safflower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibroblasts in synergy with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). Serotonin 0-9 fibroblast growth factor 2 Mus musculus 220-224 10514821-5 1999 Here, we briefly describe the techniques of random transgene insertion and gene targeting and discuss how these methods were used to generate the epileptic jerky and 5-hydroxytryptamine (5-HT2C) receptor deficient mice. Serotonin 166-185 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 187-203 9641549-15 1998 5-Hydroxytryptamine (0.1 nM-10 microM) also inhibited bFGF-stimulated re-growth (pIC50=8.36+/-0.11) and angiopeptin had no effect on this response (pKB<7). Serotonin 0-19 fibroblast growth factor 2 Rattus norvegicus 54-58 10202537-4 1999 MAO A knock-out mice have elevated brain levels of serotonin, norephinephrine, and dopamine and manifest aggressive behavior similar to human males with a deletion of MAO A. Serotonin 51-60 monoamine oxidase A Mus musculus 0-5 10216183-0 1999 Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 15-21 10897801-4 1999 MAO-A and MAO-B activities were estimated with radioassays employing serotonin and beta-phenylethylamine, respectively and specific inhibitors, clorgyline and deprenyl. Serotonin 69-78 monoamine oxidase A Rattus norvegicus 0-5 9610920-1 1998 The general purpose of the present study was to analyze the possible interactions between the GABA benzodiazepine and the serotonin systems in the mediation of the antianxiety actions of 5-HT1A compounds. Serotonin 122-131 5-hydroxytryptamine receptor 1A Rattus norvegicus 187-193 9705076-0 1998 Serotonin regulates the expression of the gene for alpha2-macroglobulin in myometrial smooth muscle cells. Serotonin 0-9 alpha-2-macroglobulin Rattus norvegicus 51-71 9705076-4 1998 Here we show that serotonin is also a negative regulator of the expression of anti-protease alpha2-macroglobulin (alpha2M) in SMC. Serotonin 18-27 alpha-2-macroglobulin Rattus norvegicus 92-112 10216183-1 1999 Previously, serotonin (5-HT) was found to induce a marked increase in glutamatergic spontaneous excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Serotonin 12-21 5-hydroxytryptamine receptor 2A Rattus norvegicus 234-240 9705076-4 1998 Here we show that serotonin is also a negative regulator of the expression of anti-protease alpha2-macroglobulin (alpha2M) in SMC. Serotonin 18-27 alpha-2-macroglobulin Rattus norvegicus 114-121 10219624-2 1999 In the present study we investigated the intracellular localization of chromogranin A, a protein co-stored with serotonin in the EC cells, after stimulating the luminal release of serotonin. Serotonin 112-121 chromogranin A Rattus norvegicus 71-85 9490827-14 1998 We conclude that serotonin potently suppresses excitatory synaptic transmission via 5-HT1A receptors in layers II and III of the medial entorhinal cortex by a presynaptic mechanism. Serotonin 17-26 5-hydroxytryptamine receptor 1A Rattus norvegicus 84-90 10501449-4 1999 The reduction by buspirone of serotonin levels was abolished by the serotonin1A receptor antagonist, WAY 100,635 (0.16), which did not, however, modify its influence upon dopamine and noradrenaline. Serotonin 30-39 5-hydroxytryptamine receptor 1A Rattus norvegicus 68-88 10219624-2 1999 In the present study we investigated the intracellular localization of chromogranin A, a protein co-stored with serotonin in the EC cells, after stimulating the luminal release of serotonin. Serotonin 180-189 chromogranin A Rattus norvegicus 71-85 10223282-11 1999 It is concluded that 5-HT1A, 5-HT2A+2C, and to a lesser extent 5-HT1B receptors, but not 5-HT3 receptors are involved in the effects of serotonin agonists on ACTH secretion. Serotonin 136-145 5-hydroxytryptamine receptor 1A Rattus norvegicus 21-27 10389141-2 1999 MAO A preferentially oxidizes serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), whereas MAO B preferentially oxidizes phenylethylamine (PEA). Serotonin 30-39 monoamine oxidase A Mus musculus 0-5 10389141-2 1999 MAO A preferentially oxidizes serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), whereas MAO B preferentially oxidizes phenylethylamine (PEA). Serotonin 41-60 monoamine oxidase A Mus musculus 0-5 10389141-2 1999 MAO A preferentially oxidizes serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), whereas MAO B preferentially oxidizes phenylethylamine (PEA). Serotonin 62-66 monoamine oxidase A Mus musculus 0-5 9928058-3 1998 These effects were not affected by the presence of atropine, hexamethonium, or TTX, suggesting that VIP, PACAP 38 and 27 exert a direct inhibitory effect on the luminal release of 5HT from the EC cells. Serotonin 180-183 adenylate cyclase activating polypeptide 1 Rattus norvegicus 105-110 9928058-4 1998 Nitric oxide synthase inhibitor, NG-nitro-L-arginine, antagonized the inhibitory effects of VIP, PACAP 38 and 27, suggesting that nitric oxide seems to be essential to exert the inhibitory action of VIP and PACAPs on the release of 5HT into the intestinal lumen from the EC cells. Serotonin 232-235 adenylate cyclase activating polypeptide 1 Rattus norvegicus 97-102 9461580-6 1998 In contrast, the replacement of many residues in TMD5-8 of VMAT2 with equivalent residues from VMAT1 improves the recognition of both serotonin and tryptamine, and these mutations show a dominant effect on the recognition of both tryptamine and serotonin over mutations in TMD9-12. Serotonin 134-143 solute carrier family 18 member A2 Homo sapiens 59-64 9461580-6 1998 In contrast, the replacement of many residues in TMD5-8 of VMAT2 with equivalent residues from VMAT1 improves the recognition of both serotonin and tryptamine, and these mutations show a dominant effect on the recognition of both tryptamine and serotonin over mutations in TMD9-12. Serotonin 134-143 solute carrier family 18 member A1 Homo sapiens 95-100 9461580-6 1998 In contrast, the replacement of many residues in TMD5-8 of VMAT2 with equivalent residues from VMAT1 improves the recognition of both serotonin and tryptamine, and these mutations show a dominant effect on the recognition of both tryptamine and serotonin over mutations in TMD9-12. Serotonin 245-254 solute carrier family 18 member A2 Homo sapiens 59-64 9461580-6 1998 In contrast, the replacement of many residues in TMD5-8 of VMAT2 with equivalent residues from VMAT1 improves the recognition of both serotonin and tryptamine, and these mutations show a dominant effect on the recognition of both tryptamine and serotonin over mutations in TMD9-12. Serotonin 245-254 solute carrier family 18 member A1 Homo sapiens 95-100 9871099-2 1998 Intravenous injection of [123I]nor-beta-CIT resulted in high accumulation of radioactivity in brain areas with high densities of serotonin (hypothalamus) and dopamine transporters (striatum), although the binding was less pronounced in the hypothalamus. Serotonin 129-138 citron rho-interacting serine/threonine kinase Rattus norvegicus 40-43 10223282-11 1999 It is concluded that 5-HT1A, 5-HT2A+2C, and to a lesser extent 5-HT1B receptors, but not 5-HT3 receptors are involved in the effects of serotonin agonists on ACTH secretion. Serotonin 136-145 5-hydroxytryptamine receptor 2A Rattus norvegicus 29-35 10208305-0 1999 Effects of local MAO inhibition in the locus coeruleus on extracellular serotonin and 5-HIAA during exposure to sensory and cardiovascular stimuli. Serotonin 72-81 monoamine oxidase A Rattus norvegicus 17-20 10599142-3 1998 Aldose reductase inhibitors (AL-1576, sorbinil) administration leads to partial restoration of serotonin and GABA release, while picamilon restored only GABA release. Serotonin 95-104 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 9453582-0 1998 Lasting increase in serotonin 5-HT1A but not 5-HT4 receptor subtypes in the kindled rat dentate gyrus: dissociation from local presynaptic effects. Serotonin 20-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 30-36 9886078-1 1999 Single treatment with the serotonin (5-hydroxytryptamine) 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and alnespirone (S-20499) reduces the extracellular 5-HT concentration (5-HText) in the rat midbrain and forebrain. Serotonin 26-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 58-64 9444479-4 1998 Under physiological fluctuations of corticosteroid concentrations, predominantly MR-mediated effects suppress the activity of the raphe-hippocampal system, notably serotonin (5-HT)1A receptor-related activity: 5-HT1A receptors are down-regulated, and the cellular response to 5-HT1A receptor activation is attenuated. Serotonin 164-173 nuclear receptor subfamily 3 group C member 2 Homo sapiens 81-83 9475626-4 1997 In contrast, the serotonin (5-HT1A) agonist 8-OHDPAT (5 microg) produced only a small effect on locomotor activity but reduced hippocampal serotonin output by 51%. Serotonin 17-26 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-34 9475626-4 1997 In contrast, the serotonin (5-HT1A) agonist 8-OHDPAT (5 microg) produced only a small effect on locomotor activity but reduced hippocampal serotonin output by 51%. Serotonin 139-148 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-34 9680375-6 1998 BMCMC in SCF released serotonin, 14C-labeled arachidonic acid metabolites and tumor necrosis factor-alpha (TNF-alpha) on stimulation with MBP, while no response was seen from either BMCMC in CM or Cl.MC/C57.1 cells. Serotonin 22-31 myelin basic protein Mus musculus 138-141 9603782-5 1998 In addition, a subpopulation of cells co-storing serotonin and gastrin display Nkx 6.1-positive nuclei. Serotonin 49-58 NK6 homeobox 1 Rattus norvegicus 79-86 9603782-9 1998 Our data show that Pdx-1 is needed for Nkx 6.1 expression and suggest a role for Nkx 6.1 in the maturation of gastrin- and serotonin-positive precursor cells. Serotonin 123-132 NK6 homeobox 1 Rattus norvegicus 81-88 9669494-1 1998 Pretreatment with the dopamine D2 receptor agonist quinpirole (0.025-2.5 mg/kg) produced a marked, dose-dependent, attenuation of the striatal Fos expression induced by the serotonin (5-Hydroxytryptamine, 5-HT) releasing agent fenfluramine (25 mg/kg). Serotonin 173-182 dopamine receptor D2 Homo sapiens 22-42 9669494-1 1998 Pretreatment with the dopamine D2 receptor agonist quinpirole (0.025-2.5 mg/kg) produced a marked, dose-dependent, attenuation of the striatal Fos expression induced by the serotonin (5-Hydroxytryptamine, 5-HT) releasing agent fenfluramine (25 mg/kg). Serotonin 184-203 dopamine receptor D2 Homo sapiens 22-42 9886078-1 1999 Single treatment with the serotonin (5-hydroxytryptamine) 5-HT1A receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and alnespirone (S-20499) reduces the extracellular 5-HT concentration (5-HText) in the rat midbrain and forebrain. Serotonin 38-56 5-hydroxytryptamine receptor 1A Rattus norvegicus 58-64 9705076-8 1998 On the other hand, progesterone, the major steroid hormone of pregnancy, is capable of reversing the serotonin-mediated inhibition of alpha2M. Serotonin 101-110 alpha-2-macroglobulin Rattus norvegicus 134-141 10591056-2 1999 MAO-A preferentially oxidizes 5-HT and NE, whereas MAO-B preferentially oxidizes PEA. Serotonin 30-34 monoamine oxidase A Mus musculus 0-5 9705076-10 1998 The cell-permeable cyclic AMP analogue 8-bromoadenosine 3":5"-cyclic monophosphate sodium salt (8-bromo-cAMP), is, however, capable of fully reproducing the action of serotonin on alpha2M. Serotonin 167-176 alpha-2-macroglobulin Rattus norvegicus 180-187 9465015-6 1998 Blockade of this response revealed a hyperpolarization mediated by serotonin acting on 5-HT1A receptors. Serotonin 67-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 87-93 9512079-1 1998 We have previously reported that the serotonin 5-HT1A agonist 8-OH-DPAT and the 5-HT2c agonist TFMPP impair performance on a water maze. Serotonin 37-46 5-hydroxytryptamine receptor 1A Rattus norvegicus 47-53 9512079-10 1998 These experiments demonstrate that serotonin agonists, especially the 5-HT1A subtype, can impair learning. Serotonin 35-44 5-hydroxytryptamine receptor 1A Rattus norvegicus 70-76 9570466-0 1998 Effect of the reversible monoamine oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission. Serotonin 78-97 monoamine oxidase A Rattus norvegicus 25-44 9570466-1 1998 The aim of the present study was to assess, using in vivo electrophysiological paradigms, the effect of sustained administration of the selective and reversible monoamine oxidase-A inhibitor beflotaxone on serotonin (5-hydroxytryptamine, 5-HT) neurotransmission. Serotonin 206-215 monoamine oxidase A Rattus norvegicus 161-180 9519268-0 1998 Serotonin regulates synaptic connections in the dentate molecular layer of adult rats via 5-HT1a receptors: evidence for a glial mechanism. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 90-96 9543235-2 1998 Its influence on serotonin, but not dopamine or noradrenaline, levels was enhanced by the 5-HT1A receptor antagonist, WAY 100,635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclo-hexanecarboxamide 3HCl) (0.16 mg kg(-1), s.c). Serotonin 17-26 5-hydroxytryptamine receptor 1A Rattus norvegicus 90-96 9543235-4 1998 Thus, blockade of 5-HT1A (auto)receptors selectively facilitates the influence of duloxetine on serotonin levels in the frontal cortex in rats and, in the forced swimming model, enhances its "antidepressant" properties in parallel. Serotonin 96-105 5-hydroxytryptamine receptor 1A Rattus norvegicus 18-24 9374800-1 1997 Serotonin (5-HT) interacts with thyrotropin-releasing hormone (TRH) at the dorsal vagal complex (DVC) to augment TRH-induced stimulation of gastric acid secretion. Serotonin 0-9 thyrotropin releasing hormone Rattus norvegicus 32-61 9374800-1 1997 Serotonin (5-HT) interacts with thyrotropin-releasing hormone (TRH) at the dorsal vagal complex (DVC) to augment TRH-induced stimulation of gastric acid secretion. Serotonin 0-9 thyrotropin releasing hormone Rattus norvegicus 63-66 9374800-1 1997 Serotonin (5-HT) interacts with thyrotropin-releasing hormone (TRH) at the dorsal vagal complex (DVC) to augment TRH-induced stimulation of gastric acid secretion. Serotonin 0-9 thyrotropin releasing hormone Rattus norvegicus 113-116 9517442-10 1997 This study provides evidence suggesting that in rat CA1 pyramidal neurons, serotonin can inhibit epileptiform activity in a variety of accepted epilepsy cellular models and that inhibition of epileptiform bursts by serotonin may be mediated by activation of the 5-HT1A receptor subtype. Serotonin 215-224 5-hydroxytryptamine receptor 1A Rattus norvegicus 262-268 9367815-6 1997 Kinetic constants Km and Vmax of recombinant AADC for the natural substrates L-dihydroxyphenylalanine and 5-hydroxytryptamine were 0.14 mM and 8444 U/mg, and 0.066 mM and 1813 U/mg, respectively. Serotonin 106-125 dopa decarboxylase Rattus norvegicus 45-49 9384247-2 1997 In view of recent studies showing that 5-HT1A receptor antagonists (somatodendritic autoreceptor antagonists) enhance the increase in extracellular 5-hydroxytryptamine (5-HT, serotonin) produced by serotonin reuptake inhibitors, it was of interest to determine if these antagonists also enhance the anticonvulsant effect of fluoxetine in Genetically Epilepsy-Prone Rats (GEPRs). Serotonin 198-207 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-45 9384247-5 1997 These findings provide further evidence that the increase in extracellular serotonin observed after administering fluoxetine in combination with a 5-HT1A receptor antagonist is physiologically important and that the anticonvulsant effect of fluoxetine in the GEPR is mediated through an increase in extracellular 5-HT. Serotonin 75-84 5-hydroxytryptamine receptor 1A Rattus norvegicus 147-153 9326273-1 1997 Serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A and 5-HT2C receptors belong to the class of phosphoinositide-specific phospholipase C (PLC)-linked receptors. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 38-50 9326273-1 1997 Serotonin (5-hydroxytryptamine; 5-HT) 5-HT2A and 5-HT2C receptors belong to the class of phosphoinositide-specific phospholipase C (PLC)-linked receptors. Serotonin 11-30 5-hydroxytryptamine receptor 2A Rattus norvegicus 38-50 9326274-2 1997 Uptake and cellular retention of 3H-catecholamines was increased by up to fourfold by two COMT inhibitors, tropolone and Ro 41-0960, with potencies similar to those for inhibition of COMT activity, whereas the uptake of two transporter substrates that are not substrates for COMT, [3H]serotonin and [3H]MPP+, was unaffected. Serotonin 285-294 catechol-O-methyltransferase Homo sapiens 90-94 9282959-1 1997 Efficacies of the 5-hydroxytryptamine (serotonin) 5-HT3 receptor (5-HT3R) agonists 2-methyl-5-HT, dopamine, and m-chlorophenylbiguanide on 5-HT3R native to N1E-115 cells and on homopentameric 5-HT3R expressed in Xenopus oocytes were determined relative to that of 5-HT. Serotonin 18-37 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 50-64 9282959-1 1997 Efficacies of the 5-hydroxytryptamine (serotonin) 5-HT3 receptor (5-HT3R) agonists 2-methyl-5-HT, dopamine, and m-chlorophenylbiguanide on 5-HT3R native to N1E-115 cells and on homopentameric 5-HT3R expressed in Xenopus oocytes were determined relative to that of 5-HT. Serotonin 18-37 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 66-72 9286623-1 1997 Subcutaneous administration of amylin (20-40 micrograms/kg) prevented, in a dose-dependent manner, reserpine- and serotonin-induced gastric damage, but the anti-ulcer effect was not present when lesions were induced by pylorus ligation. Serotonin 114-123 islet amyloid polypeptide Homo sapiens 31-37 9239754-2 1997 Consistent with previous reports, GAP-43 mRNA was observed in serotonin and dopamine cell groups in the pons. Serotonin 62-71 growth associated protein 43 Rattus norvegicus 34-40 9204940-9 1997 These results indicate that serotonin released from terminals in the hippocampus activates a 5-HT1a receptor on interneurons that suppresses their activity and thus enhances dentate granular cell population spike response to PP stimulation. Serotonin 28-37 5-hydroxytryptamine receptor 1A Rattus norvegicus 93-99 9222551-2 1997 Selective 5-hydroxytryptamine (5-HT; serotonin) reuptake inhibitors (SSRIs) cause a greater increase in extracellular 5-HT in the forebrain when the somatodendritic 5-HT1A autoreceptor is blocked. Serotonin 10-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 165-171 9222551-2 1997 Selective 5-hydroxytryptamine (5-HT; serotonin) reuptake inhibitors (SSRIs) cause a greater increase in extracellular 5-HT in the forebrain when the somatodendritic 5-HT1A autoreceptor is blocked. Serotonin 37-46 5-hydroxytryptamine receptor 1A Rattus norvegicus 165-171 9096150-10 1997 We suggest that serotonin through the 5-HT3R may regulate GABA and CCK neurotransmission in the telencephalon. Serotonin 16-25 5-hydroxytryptamine receptor 3A Rattus norvegicus 38-44 9134653-4 1997 Incubation with 0.2 CU/ml of plasmin almost completely inhibited thrombin-induced (0.1 U/ml) aggregation, release of 14C-serotonin, and increase in cytosolic [Ca2+]. Serotonin 121-130 plasminogen Homo sapiens 29-36 9060603-5 1997 Ten TGF-alpha-positive tumors were positive for serotonin, seven for somatostatin, three for calcitonin, and one tumor each for gastrin, glucagon, pancreatic polypeptide, vasoactive intestinal peptide, and growth hormone-releasing factor, respectively. Serotonin 48-57 transforming growth factor alpha Homo sapiens 4-13 9051259-0 1997 5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells. Serotonin 52-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-6 9120070-8 1997 Dopamine-N-acetyltransferase, which is on the catabolic route to dopamine, serotonin, and octopamine, has no effect. Serotonin 75-84 Arylalkylamine N-acetyltransferase 1 Drosophila melanogaster 0-28 9021891-1 1997 The present study investigated alterations of the regulation of serotonin (5-hydroxytryptamine; 5-HT) release by 5-HT1A autoreceptors following single and repeated treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT). Serotonin 64-73 5-hydroxytryptamine receptor 1A Rattus norvegicus 113-119 9021891-1 1997 The present study investigated alterations of the regulation of serotonin (5-hydroxytryptamine; 5-HT) release by 5-HT1A autoreceptors following single and repeated treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT). Serotonin 75-94 5-hydroxytryptamine receptor 1A Rattus norvegicus 113-119 9016798-0 1997 Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 46-52 8978504-6 1996 These data suggest that the action of serotonin via 5-HT1A receptor could occur through junctional as well as nonjunctional transmission. Serotonin 38-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 8987838-0 1996 GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine. Serotonin 48-57 glial cell derived neurotrophic factor Rattus norvegicus 0-4 8982718-0 1996 5-HT1A receptor agonist effects of BMY-14802 on serotonin release in dorsal raphe and hippocampus. Serotonin 48-57 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-6 10591056-5 1999 MAO-A KO mice have elevated brain levels of 5-HT, NE and DA and manifest aggressive behavior similar to men with a deletion of MAO-A. Serotonin 44-48 monoamine oxidase A Mus musculus 0-5 9928058-0 1998 Effect of VIP and PACAP on vascular and luminal release of serotonin from isolated perfused rat duodenum. Serotonin 59-68 adenylate cyclase activating polypeptide 1 Rattus norvegicus 18-23 9928058-2 1998 VIP, PACAP 38 and 27 reduced the release of 5HT into the lumen but did not affect the vascular release of 5HT. Serotonin 44-47 adenylate cyclase activating polypeptide 1 Rattus norvegicus 5-10 9843894-10 1998 The results suggest that excitatory responses to serotonin are mediated by 5-HT2A or 5-HT2C receptors and that inhibitory responses may be mediated by 5-HT1A receptors. Serotonin 49-58 5-hydroxytryptamine receptor 2A Rattus norvegicus 75-81 8914926-1 1996 Monoamine oxidases A/B (EC 1.4.3.4, MAO), flavoenzymes located on the outer mitochondrial membrane, catalyze the oxidative deamination of biogenic amines, such as dopamine, serotonin, and norepinephrine. Serotonin 173-182 monoamine oxidase A Rattus norvegicus 0-22 8914926-1 1996 Monoamine oxidases A/B (EC 1.4.3.4, MAO), flavoenzymes located on the outer mitochondrial membrane, catalyze the oxidative deamination of biogenic amines, such as dopamine, serotonin, and norepinephrine. Serotonin 173-182 monoamine oxidase A Rattus norvegicus 36-39 9862032-3 1998 Variable amounts of serotonin-immunoreactive cells co-storing CgA or SgIIC26-3, but never both granins, were encountered in all intestinal segments of the frogs investigated. Serotonin 20-29 chromogranin A L homeolog Xenopus laevis 62-65 8912226-2 1996 Initially, the Ki value for 5-hydroxytryptamine (5-HT) binding to a site labeled by the 5-HT1A-selective ligand [3H]8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) was 20-fold higher than the KD for [3H]5-HT. Serotonin 28-47 5-hydroxytryptamine receptor 1A Rattus norvegicus 88-94 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 20-23 8870031-3 1996 However, in vivo microdialysis studies show that generally such 5-HT1A antagonists by themselves do not increase the basal 5-HT release but potentiate the ability of serotonin reuptake blockers to increase the neuronal serotonin terminal output in the rat brain via the above mechanism. Serotonin 166-175 5-hydroxytryptamine receptor 1A Rattus norvegicus 64-70 8864759-2 1996 PTPS is a biosynthetic enzyme for the BH4 co-factor, and its deficiency is associated with a malfunction of the phenylalanine catabolism in the liver and a lack of biogenic amine neurotransmitters dopamine and serotonin in the brain. Serotonin 210-219 6-pyruvoyltetrahydropterin synthase Homo sapiens 0-4 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 98-101 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 98-101 8840347-6 1996 These data support the conclusion that serotonin released onto 5-HT2A receptors contributes to MDMA-stimulated locomotion and suggest that MDMA-stimulated locomotion may be useful as an in vivo behavioral measure of 5-HT2A antagonism. Serotonin 39-48 5-hydroxytryptamine receptor 2A Rattus norvegicus 63-69 9813366-3 1998 We further examined MAO activity in these neurons using other substrates, including serotonin (an MAO type A preferential substrate), beta-phenylethylamine (an MAO type B preferential substrate), and tyramine (a substrate common to both MAO types A and B). Serotonin 84-93 monoamine oxidase A Rattus norvegicus 98-101 8840347-6 1996 These data support the conclusion that serotonin released onto 5-HT2A receptors contributes to MDMA-stimulated locomotion and suggest that MDMA-stimulated locomotion may be useful as an in vivo behavioral measure of 5-HT2A antagonism. Serotonin 39-48 5-hydroxytryptamine receptor 2A Rattus norvegicus 216-222 9813366-8 1998 Our results suggest that dopamine-degrading MAO activity and MAO types A and B activities in SNC dopamine neurons are very low compared to MAO activity in LC noradrenaline neurons and in DR serotonin neurons. Serotonin 190-199 monoamine oxidase A Rattus norvegicus 44-47 9712661-0 1998 Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. Serotonin 32-41 monoamine oxidase A Mus musculus 152-171 8783276-1 1996 L-3,4-Dihydroxyphenylalanine (L-DOPA) inhibits the activity of tryptophan hydroxylase (TRH) and thus serotonin synthesis. Serotonin 101-110 thyrotropin releasing hormone Rattus norvegicus 63-85 8783276-1 1996 L-3,4-Dihydroxyphenylalanine (L-DOPA) inhibits the activity of tryptophan hydroxylase (TRH) and thus serotonin synthesis. Serotonin 101-110 thyrotropin releasing hormone Rattus norvegicus 87-90 9712661-0 1998 Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs. Serotonin 80-89 monoamine oxidase A Mus musculus 152-171 8813364-1 1996 The aim of the present study is to examine by immunohistochemistry whether dopamine produced from L-DOPA in serotonin neurons of the rat brain is degraded by endogenous monoamine oxidase (MAO). Serotonin 108-117 monoamine oxidase A Rattus norvegicus 169-186 9712661-1 1998 Genetic loss or pharmacological inhibition of monoamine oxidase A (MAOA) in mice leads to a large increase in whole-brain levels of serotonin (5-HT). Serotonin 132-141 monoamine oxidase A Mus musculus 46-65 8813364-1 1996 The aim of the present study is to examine by immunohistochemistry whether dopamine produced from L-DOPA in serotonin neurons of the rat brain is degraded by endogenous monoamine oxidase (MAO). Serotonin 108-117 monoamine oxidase A Rattus norvegicus 188-191 9712661-1 1998 Genetic loss or pharmacological inhibition of monoamine oxidase A (MAOA) in mice leads to a large increase in whole-brain levels of serotonin (5-HT). Serotonin 132-141 monoamine oxidase A Mus musculus 67-71 9732399-0 1998 S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: II. Serotonin 160-169 5-hydroxytryptamine receptor 1A Rattus norvegicus 171-178 9716348-1 1998 We have used the rat to examine the involvement of the 5-HT3 receptor in the mechanism(s) of conditioned taste aversion induced by 5-hydroxytryptamine (5-HT) and selected emetic drugs. Serotonin 131-150 5-hydroxytryptamine receptor 3A Rattus norvegicus 55-69 8612503-5 1996 injection of 5-hydroxy-L-tryptophan (1 mg/100 g BW), a precursor of serotonin, was blunted by PACAP-(6-38) (1 nmol/100 g BW, i.v. Serotonin 68-77 adenylate cyclase activating polypeptide 1 Rattus norvegicus 94-99 9422359-3 1998 The double-label immunofluorescence technique was used to localize GTP cyclohydrolase I protein to the tyrosine hydroxylase-positive A9 dopamine neurons of the substantia nigra and the A6 norepinephrine neurons of the locus ceruleus or the tryptophan hydroxylase-positive B6/B7 serotonin neurons of the dorsal raphe nucleus. Serotonin 278-287 GTP cyclohydrolase 1 Homo sapiens 67-87 9422359-4 1998 Although GTP cyclohydrolase I immunofluorescence within serotonin and norepinephrine neurons was relatively intense, the fluorescence signal within dopamine neurons was faint to nondetectable. Serotonin 56-65 GTP cyclohydrolase 1 Homo sapiens 9-29 9422359-6 1998 Significant differences between all three neurochemical subdivisions were found and comparisons showed that on average serotonin neurons contain between 2.3- and 7.3-fold more GTP cyclohydrolase I protein than do either norepinephrine or dopamine neurons, respectively. Serotonin 119-128 GTP cyclohydrolase 1 Homo sapiens 176-196 9485168-0 1998 Role of vasoactive intestinal peptide and 5-HT2 receptor subtype in serotonin stimulation of basal and thyrotropin-releasing-hormone-induced prolactin release in vitro from rat pituitary cells. Serotonin 68-77 thyrotropin releasing hormone Rattus norvegicus 103-132 9622542-1 1998 Since it was known that 5HT properties (5HT1A agonism or 5HT2A antagonism) combined with D2 antagonism may lead to atypical antipsychotic drugs, a series of 19 benzothiazolin-2-one and benzoxazin-3-one derivatives possessing the arylpiperazine moiety was prepared, and their binding profiles were investigated. Serotonin 24-27 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-45 9572479-0 1998 Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors. Serotonin 109-118 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 67-95 9769705-13 1998 Both serotonin, acting through 5-HT2C receptors, and norepinephrine, acting through beta 2 and/or beta 3 receptors, reduce food intake. Serotonin 5-14 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 31-37 8738109-0 1996 Effects of serotonin on the release of thyrotropin-releasing hormone from the rat retina in vitro. Serotonin 11-20 thyrotropin releasing hormone Rattus norvegicus 39-68 9572479-0 1998 Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors. Serotonin 109-118 5-hydroxytryptamine receptor 2A Rattus norvegicus 123-129 8738109-1 1996 Effects of serotonin on the release of thyrotropin-releasing hormone (TRH) from the rat retina were studied in vitro. Serotonin 11-20 thyrotropin releasing hormone Rattus norvegicus 39-68 8738109-1 1996 Effects of serotonin on the release of thyrotropin-releasing hormone (TRH) from the rat retina were studied in vitro. Serotonin 11-20 thyrotropin releasing hormone Rattus norvegicus 70-73 9408240-5 1997 Precontraction of bovine carotid artery smooth muscle with serotonin followed by relaxation with forskolin was associated with increases in the phosphorylation of HSP27 and HSP20. Serotonin 59-68 heat shock protein beta-6 Bos taurus 173-178 9572479-1 1998 Signaling pathways responsible for serotonin (5-HT)-mediated induction of early response genes prostaglandin G/H synthase-2 (PGHS-2, cyclooxygenase-2) and egr-1 were investigated in rat mesangial cells. Serotonin 35-44 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 95-123 9517442-0 1997 Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 59-65 8738109-4 1996 The TRH release from the rat retina was inhibited significantly in a dose-related manner with the addition of serotonin and enhanced with cyproheptadine. Serotonin 110-119 thyrotropin releasing hormone Rattus norvegicus 4-7 9572479-1 1998 Signaling pathways responsible for serotonin (5-HT)-mediated induction of early response genes prostaglandin G/H synthase-2 (PGHS-2, cyclooxygenase-2) and egr-1 were investigated in rat mesangial cells. Serotonin 35-44 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 125-131 8738109-5 1996 The inhibitory effect of serotonin on TRH release from the retina was blocked with the addition of cyproheptadine. Serotonin 25-34 thyrotropin releasing hormone Rattus norvegicus 38-41 9572479-1 1998 Signaling pathways responsible for serotonin (5-HT)-mediated induction of early response genes prostaglandin G/H synthase-2 (PGHS-2, cyclooxygenase-2) and egr-1 were investigated in rat mesangial cells. Serotonin 35-44 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 133-149 9562184-4 1998 This decrease probably occurred via inhibition of GAT-2 or GAT-3 activity since their inhibitor, beta-alanine, induced a decrease in [3H]-GABA uptake in punches of sham-operated rats (-28%), but not in punches of 5,7-DHT-treated rats, demonstrating that serotonin terminal degeneration had already impaired the beta-alanine-sensitive component of GABA uptake. Serotonin 254-263 solute carrier family 6 member 13 Rattus norvegicus 50-55 9503569-1 1997 Vladimir Zinovievich Gorkin"s theory of the transformation of catalytic activity of amine oxidases and, therweby, selectivity of amine oxidases, carried over from my personal acquaintance with Vladimir Zinovievich, significantly influenced our studies into the mechanism of MAO-induced stimulation of pineal melatonin biosynthesis from serotonin. Serotonin 336-345 monoamine oxidase A Rattus norvegicus 274-277 9652362-0 1998 Differential regional antagonism of 8-OH-DPAT-induced decrease in serotonin synthesis by two 5-HT1A receptor antagonists. Serotonin 66-75 5-hydroxytryptamine receptor 1A Rattus norvegicus 93-99 9383015-9 1997 The present data suggest that serotonin, a preferential substrate for MAOA, can be oxidized by MAOB in MAOA-deficient Tg8 mice. Serotonin 30-39 monoamine oxidase A Mus musculus 70-74 9514208-3 1998 In this report, we tested the effect of intracranially infused serotonin-activated rat alpha1M (5HT-alpha1M) on the concentration of dopamine (DA) in the corpus striatum in vivo and the effect of 5HT-activated rat alpha1M and alpha2M on the choline acetyltransferase (ChAT) activity upon embryonic basal forebrain neurons in culture. Serotonin 63-72 alpha-2-macroglobulin Rattus norvegicus 226-233 9372196-2 1997 5-Carboxamidotryptamine, a 5-HT1 agonist, and the selective 5-HT1A agonist 8-hydroxy-dipropylaminotetralin mimicked the action of serotonin. Serotonin 130-139 5-hydroxytryptamine receptor 1A Rattus norvegicus 60-66 9443841-0 1998 Feedback stimulation of somatodendritic serotonin release: a 5-HT3 receptor-mediated effect in the raphe nuclei of the rat. Serotonin 40-49 5-hydroxytryptamine receptor 3A Rattus norvegicus 61-75 9242289-1 1997 The Ca2+-calmodulin-dependent protein kinase II (CaMKII) inhibitor, [1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne) (KN-62), was used to investigate the role of CaMKII in synaptic transmission and serotonin (5-HT)-induced facilitation in Aplysia. Serotonin 226-235 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 4-47 9242289-1 1997 The Ca2+-calmodulin-dependent protein kinase II (CaMKII) inhibitor, [1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne) (KN-62), was used to investigate the role of CaMKII in synaptic transmission and serotonin (5-HT)-induced facilitation in Aplysia. Serotonin 237-241 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 4-47 9698044-4 1998 Animals were sacrificed at 3 weeks and MAO-A and -B activity was assessed in homogenates of heart, liver, lung, uterus, kidney, adrenal and small intestine using 5-hydroxytryptamine and phenylethylamine as substrates. Serotonin 162-181 monoamine oxidase A Rattus norvegicus 39-51 9212275-3 1997 The inhibitory effects of 5HT and the 5HT1A agonist 8-OH-DPAT were shown to be antagonized by the 5HT1A antagonists spiperone and pindolol, respectively, indicating involvement of a 5HT1A receptor. Serotonin 26-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 98-103 9212275-3 1997 The inhibitory effects of 5HT and the 5HT1A agonist 8-OH-DPAT were shown to be antagonized by the 5HT1A antagonists spiperone and pindolol, respectively, indicating involvement of a 5HT1A receptor. Serotonin 26-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 98-103 9375971-2 1997 We have examined the effects of the systemic administration of the selective 5-HT1A agonist alnespirone (S-20499) on in vivo 5-hydroxytryptamine (5-HT) release in the dorsal raphe nucleus, the median raphe nucleus and four forebrain areas innervated differentially by both (dorsal striatum, frontal cortex, ventral hippocampus and dorsal hippocampus). Serotonin 125-144 5-hydroxytryptamine receptor 1A Rattus norvegicus 77-83 9202747-4 1997 Expression of rat acetyltransferases responsible for acetylation of the nitrogen and the oxygen of arylamine derivatives (i.e., acetyltransferases 1 and 2) in bacterial cells has now permitted experiments which demonstrate that these enzymes exhibit good affinities for and N-acetylation of the endogenous arylalkylamines derived from tryptophan, i.e., tryptamine, 5-hydroxytryptamine (serotonin) and 5-methoxytryptamine, the immediate metabolic precursor of melatonin. Serotonin 365-384 N-acetyltransferase 8 Rattus norvegicus 128-154 9202747-4 1997 Expression of rat acetyltransferases responsible for acetylation of the nitrogen and the oxygen of arylamine derivatives (i.e., acetyltransferases 1 and 2) in bacterial cells has now permitted experiments which demonstrate that these enzymes exhibit good affinities for and N-acetylation of the endogenous arylalkylamines derived from tryptophan, i.e., tryptamine, 5-hydroxytryptamine (serotonin) and 5-methoxytryptamine, the immediate metabolic precursor of melatonin. Serotonin 386-395 N-acetyltransferase 8 Rattus norvegicus 128-154 9384247-2 1997 In view of recent studies showing that 5-HT1A receptor antagonists (somatodendritic autoreceptor antagonists) enhance the increase in extracellular 5-hydroxytryptamine (5-HT, serotonin) produced by serotonin reuptake inhibitors, it was of interest to determine if these antagonists also enhance the anticonvulsant effect of fluoxetine in Genetically Epilepsy-Prone Rats (GEPRs). Serotonin 148-167 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-45 9384247-2 1997 In view of recent studies showing that 5-HT1A receptor antagonists (somatodendritic autoreceptor antagonists) enhance the increase in extracellular 5-hydroxytryptamine (5-HT, serotonin) produced by serotonin reuptake inhibitors, it was of interest to determine if these antagonists also enhance the anticonvulsant effect of fluoxetine in Genetically Epilepsy-Prone Rats (GEPRs). Serotonin 175-184 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-45 9144769-1 1997 Fast synaptic neurotransmission is mediated by ligand-gated ion-channel (LGIC) receptors, which include receptors for acetylcholine, serotonin, GABA, glycine, and glutamate. Serotonin 133-142 glycine receptor alpha 3 Homo sapiens 47-71 9144769-1 1997 Fast synaptic neurotransmission is mediated by ligand-gated ion-channel (LGIC) receptors, which include receptors for acetylcholine, serotonin, GABA, glycine, and glutamate. Serotonin 133-142 glycine receptor alpha 3 Homo sapiens 73-77 9326944-2 1997 MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA). Serotonin 29-38 monoamine oxidase A Mus musculus 0-4 9326944-2 1997 MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA). Serotonin 40-59 monoamine oxidase A Mus musculus 0-4 9326944-2 1997 MAOA preferentially oxidizes serotonin (5-hydroxytryptamine, or 5-HT) and norepinephrine (NE), whereas MAOB preferentially oxidizes beta-phenylethylamine (PEA). Serotonin 64-68 monoamine oxidase A Mus musculus 0-4 9151945-2 1997 Dopamine (10 and 100 microM) and 5-hydroxytryptamine (1 to 100 microM) enhanced the inward current activated by extracellular ATP through P2X2 and P2X4 purinoceptors. Serotonin 33-52 purinergic receptor P2X, ligand gated ion channel, 2 L homeolog Xenopus laevis 138-142 9335000-1 1997 The role of vasoactive intestinal peptide (VIP) was investigated when mucosal stroking and 5-hydroxytryptamine (5-HT) were used to activate neural reflexes that stimulate chloride secretion in the guinea pig colon. Serotonin 91-110 VIP peptides Cavia porcellus 43-46 9097929-3 1997 To detect and characterize changes in intracellular free calcium ([Ca2+]i) that might be expected to be triggered by stimulation with serotonin (5-HT), we have carried out digital calcium-imaging experiments on intact glands using the Ca2+-sensitive dye fura-2. Serotonin 134-143 carbonic anhydrase 2 L homeolog Xenopus laevis 67-70 9097929-3 1997 To detect and characterize changes in intracellular free calcium ([Ca2+]i) that might be expected to be triggered by stimulation with serotonin (5-HT), we have carried out digital calcium-imaging experiments on intact glands using the Ca2+-sensitive dye fura-2. Serotonin 134-143 carbonic anhydrase 2 L homeolog Xenopus laevis 235-238 9282959-1 1997 Efficacies of the 5-hydroxytryptamine (serotonin) 5-HT3 receptor (5-HT3R) agonists 2-methyl-5-HT, dopamine, and m-chlorophenylbiguanide on 5-HT3R native to N1E-115 cells and on homopentameric 5-HT3R expressed in Xenopus oocytes were determined relative to that of 5-HT. Serotonin 39-48 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 50-64 9282959-1 1997 Efficacies of the 5-hydroxytryptamine (serotonin) 5-HT3 receptor (5-HT3R) agonists 2-methyl-5-HT, dopamine, and m-chlorophenylbiguanide on 5-HT3R native to N1E-115 cells and on homopentameric 5-HT3R expressed in Xenopus oocytes were determined relative to that of 5-HT. Serotonin 39-48 5-hydroxytryptamine (serotonin) receptor 3A Mus musculus 66-72 9225271-11 1997 The results suggest that only a combined blockade of 5-HT1A and 5-HT1B receptors potentiates the effect of citalopram on extracellular concentrations of serotonin in the dorsal hippocampus. Serotonin 153-162 5-hydroxytryptamine receptor 1A Rattus norvegicus 53-70 9322235-3 1997 SRIs block the reuptake of serotonin (5-HT) into the presynaptic neuron, a process mediated by the serotonin transporter (5-HTT). Serotonin 27-36 huntingtin Homo sapiens 124-127 9639742-1 1997 OBJECTIVE: To supply evidence of relationship between pregnancy induced hypertension (PIH) and 5-hydroxytryptamine (5-HT) and 5-hydroxytryptamine receptor (5-HTR) synthesized by placental villi. Serotonin 95-114 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 86-89 9085055-6 1997 Combined blockade of 5-HT1A and 5-HT1B autoreceptors markedly enhances the actions of serotonin reuptake inhibitors. Serotonin 86-95 5-hydroxytryptamine receptor 1A Rattus norvegicus 21-38 9296571-4 1997 Furthermore, encapsulated nerve endings in Pacinian corpuscles also contain reaction product following immunostaining for 5-HT2A receptors, indicating that large myelinated axons can be activated by endogenous serotonin. Serotonin 210-219 5-hydroxytryptamine receptor 2A Rattus norvegicus 122-128 9098747-0 1997 Comparison of histamine and serotonin release from rat peritoneal mast cells induced by nerve growth factor and compound 48/80. Serotonin 28-37 nerve growth factor Rattus norvegicus 88-107 9089665-0 1997 The effects of a 5-HT1A receptor agonist and antagonist on the 5-hydroxytryptamine release in the central nucleus of the amygdala: a microdialysis study with flesinoxan and WAY 100635. Serotonin 63-82 5-hydroxytryptamine receptor 1A Rattus norvegicus 17-23 9195934-8 1997 The mutation K446Q reduced the affinity of VMAT2 for tetrabenazine and serotonin but not histamine, whereas F464Y reduced serotonin affinity and perhaps histamine recognition but not tetrabenazine sensitivity, providing more evidence for specificity. Serotonin 71-80 solute carrier family 18 member A2 Homo sapiens 43-48 9089665-1 1997 The modulation of extracellular 5-hydroxytryptamine (5-HT) in the central nucleus of the amygdala (CeA) by 5-HT1A receptors was studied by intracerebral microdialysis in awake and freely moving rats. Serotonin 32-51 carcinoembryonic antigen gene family 4 Rattus norvegicus 99-102 9089665-1 1997 The modulation of extracellular 5-hydroxytryptamine (5-HT) in the central nucleus of the amygdala (CeA) by 5-HT1A receptors was studied by intracerebral microdialysis in awake and freely moving rats. Serotonin 32-51 5-hydroxytryptamine receptor 1A Rattus norvegicus 107-113 9195934-12 1997 Surprisingly, the residue responsible for this difference, Tyr-434, also accounts for the higher affinity interaction of VMAT2 with tetrabenazine, histamine, and serotonin. Serotonin 162-171 solute carrier family 18 member A2 Homo sapiens 121-126 9176059-1 1997 Serotonin stimulates inositol phosphate production and intracellular calcium mobilization in cultured rat retinal pigment epithelial (RPE) cells through interaction with 5-HT2A receptors, but decreases cAMP production in cultured human RPE cells via 5-HT1A receptors. Serotonin 0-9 5-hydroxytryptamine receptor 2A Rattus norvegicus 170-176 9195934-13 1997 Interestingly, replacement of Tyr-434 with alanine increases the affinity of VMAT2 for both serotonin and dopamine and reduces the rate of dopamine transport. Serotonin 92-101 solute carrier family 18 member A2 Homo sapiens 77-82 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Serotonin 111-120 monoamine oxidase A Mus musculus 18-37 9016342-3 1997 The activity of Ca2+/calmodulin-dependent protein kinase II(CaMKII), one of the kinases involved in the modulation of transmitter release, was previously shown to increase in the hippocampus after long-term blockade of 5-hydroxytryptamine (5-HT) reuptake (a treatment known to elicit an increase in 5-HT release in this area). Serotonin 219-238 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 60-66 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Serotonin 111-120 monoamine oxidase A Mus musculus 39-43 9017248-10 1996 We conclude that the apparent decrease in sensitivity of the GEPR-9 CA1 pyramidal neurons to serotonin may represent a deficiency of serotonin 5-HT1A receptor. Serotonin 93-102 5-hydroxytryptamine receptor 1A Rattus norvegicus 133-158 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Serotonin 155-164 monoamine oxidase A Mus musculus 18-37 9159177-1 1997 Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Serotonin 155-164 monoamine oxidase A Mus musculus 39-43 9025070-5 1996 Pdx1 deficient mice were virtually devoid of gastrin cells, had normal numbers of somatostatin cells and increased numbers of serotonin cells. Serotonin 126-135 pancreatic and duodenal homeobox 1 Mus musculus 0-4 9090335-1 1997 OBJECTIVE: This study was undertaken to measure serotonergic modulation of dopamine in vivo by using positron emission tomography (PET), a radiotracer for the striatal dopamine D2 receptor ([11C]raclopride), and a pharmacologic challenge of the serotonin system (d,l-fenfluramine). Serotonin 245-254 dopamine receptor D2 Homo sapiens 168-188 9025070-6 1996 Pdx1 is thus important for development of the gastrin cells of the antropyloric mucosa of the stomach and probably acts by controlling the fate of gastrin/serotonin precursor cells. Serotonin 155-164 pancreatic and duodenal homeobox 1 Mus musculus 0-4 9169102-0 1997 Serotonin decreases cytoskeletal and cytosolic glycolytic enzymes and the levels of ATP and glucose 1,6-bisphosphate in skin, which is prevented by the calmodulin antagonists thioridazine and clotrimazole. Serotonin 0-9 calmodulin 1 Rattus norvegicus 152-162 8982649-0 1996 Raphe 5-HT1A autoreceptors, but not postsynaptic 5-HT1A receptors or beta-adrenoceptors, restrain the citalopram-induced increase in extracellular 5-hydroxytryptamine in vivo. Serotonin 147-166 5-hydroxytryptamine receptor 1A Rattus norvegicus 6-12 9169102-5 1997 All these pathological changes induced by serotonin were prevented by treatment with two structurally different calmodulin antagonists: thioridazine, an antipsychotic phenothiazine, or clotrimazole, from the group of the antifungal azole derivatives that were recently recognized as calmodulin antagonists. Serotonin 42-51 calmodulin 1 Rattus norvegicus 112-122 9169102-5 1997 All these pathological changes induced by serotonin were prevented by treatment with two structurally different calmodulin antagonists: thioridazine, an antipsychotic phenothiazine, or clotrimazole, from the group of the antifungal azole derivatives that were recently recognized as calmodulin antagonists. Serotonin 42-51 calmodulin 1 Rattus norvegicus 283-293 9169102-6 1997 The present results suggest that calmodulin antagonists may be effective drugs in the treatment of skin damage under various pathological conditions and diseases in which serotonin levels are increased. Serotonin 171-180 calmodulin 1 Rattus norvegicus 33-43 9225129-0 1997 Serotonin (5-HT) stimulates thyrotropin-releasing hormone (TRH) gene transcription in rat embryonic cardiomyocytes. Serotonin 0-9 thyrotropin releasing hormone Rattus norvegicus 28-57 8971795-1 1996 The increases in extracellular serotonin (5-hydroxytryptamine; 5-HT) produced by some antidepressent drugs in forebrain are attenuated by the activation of somatodendritic 5-HT1A autoreceptors by the excess 5-HT induced by these agents in the midbrain raphe. Serotonin 31-40 5-hydroxytryptamine receptor 1A Rattus norvegicus 172-178 8971795-1 1996 The increases in extracellular serotonin (5-hydroxytryptamine; 5-HT) produced by some antidepressent drugs in forebrain are attenuated by the activation of somatodendritic 5-HT1A autoreceptors by the excess 5-HT induced by these agents in the midbrain raphe. Serotonin 42-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 172-178 9225129-0 1997 Serotonin (5-HT) stimulates thyrotropin-releasing hormone (TRH) gene transcription in rat embryonic cardiomyocytes. Serotonin 0-9 thyrotropin releasing hormone Rattus norvegicus 59-62 9109902-2 1997 The manufacturer of deprenyl (selegeline; Eldepryl) (Somerset Pharmaceuticals, Tampa, FL) recently advised physicians to avoid prescribing the drug in combination with an antidepressant because of potentially serious CNS toxicity that may represent the serotonin syndrome. Serotonin 253-262 fms related receptor tyrosine kinase 3 ligand Homo sapiens 86-88 9001709-1 1996 In the present study, we investigated the effects of chronic in vitro administration of amitriptyline, a tricyclic antidepressant, on cyclic GMP formation stimulated by 5-hydroxytryptamine (5-HT) in the neuroblastoma x glioma hybrid cell line, NG 108-15, 5-HT (0.01-100 microM)-stimulated cyclic GMP formation was concentration-dependent and was sensitive to ICS 205-930, a 5-HT3 receptor antagonist. Serotonin 169-188 5'-nucleotidase, cytosolic II Mus musculus 141-144 8945740-0 1996 The alpha 2-adrenoceptor antagonist idazoxan is an agonist at 5-HT1A autoreceptors modulating serotonin synthesis in the rat brain in vivo. Serotonin 94-103 5-hydroxytryptamine receptor 1A Rattus norvegicus 62-68 8945740-7 1996 The results indicate that idazoxan is a potent and specific agonist at 5-HT1A autoreceptors modulating brain serotonin synthesis in vivo. Serotonin 109-118 5-hydroxytryptamine receptor 1A Rattus norvegicus 71-77 8948002-8 1996 Thyrotropin-releasing hormone increases serotonin (5-HT) secretion into the stomach. Serotonin 40-49 thyrotropin releasing hormone Rattus norvegicus 0-29 8912252-1 1996 A close anatomical relationship between nerves containing substance P and calcitonin gene-related peptide (CGRP) and mast cells containing serotonin has been demonstrated in the rat lacrimal gland. Serotonin 139-148 calcitonin-related polypeptide alpha Rattus norvegicus 107-111 8912252-6 1996 The substance P evoked peroxidase secretion and serotonin release was blocked by CGRP and by sodium cromoglycate. Serotonin 48-57 calcitonin-related polypeptide alpha Rattus norvegicus 81-85 8798428-6 1996 While the addition of serotonin increased 5HT2c receptor-catalyzed GTPgammaS binding to alphaq, the unoccupied receptor was also catalytically active. Serotonin 22-31 5-hydroxytryptamine receptor 2C Bos taurus 42-47 8752121-7 1996 Serotonin-induced, magnesium-dependent reduction in PTX-mediated ADP-ribosylation of G alpha i/G alpha o in cortical membranes from bipolar brains was greater than that observed in controls, providing further evidence for enhanced receptor-G protein coupling in bipolar brain membranes. Serotonin 0-9 G protein subunit alpha o1 Homo sapiens 95-104 8813364-6 1996 These findings suggest that the newly produced dopamine from L-DOPA in serotonin neurons of the rat DR is degraded by endogenous MAO. Serotonin 71-80 monoamine oxidase A Rattus norvegicus 129-132 8963722-8 1996 The effect of Lp(a) on platelet aggregation was accompanied by a significant reduction of serotonin release and TXA2 formation. Serotonin 90-99 lipoprotein(a) Homo sapiens 14-19 8738299-1 1996 We have reported that chronic treatment of patients with beta 1-adrenoceptor blockers sensitises isolated atrial preparations to adrenaline, noradrenaline and 5-Ht. Serotonin 159-163 adrenoceptor beta 1 Homo sapiens 57-76 8738578-12 1996 The present experiments indicate that serotonin acting at the 5-HT3 receptor mediates LH and FSH release in infantile female rats, whereas 5-HT2C or 2A receptor types participate in the release of prolactin at this age. Serotonin 38-47 5-hydroxytryptamine receptor 3A Rattus norvegicus 62-76 8785063-0 1996 GDNF induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis. Serotonin 80-89 glial cell derived neurotrophic factor Rattus norvegicus 0-4 8626761-5 1996 Serotonin increased APPs release 3-4-fold in 3T3 cells stably overexpressing 5-HT2aR or 5-HT2cR. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 88-95 9013388-2 1996 treatment with interferon (IFN)-alpha-2a (300 IU/g) significantly inhibited wet-dog shakes (WDS) induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0 mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. Serotonin 204-213 interferon alpha-3 Canis lupus familiaris 15-37 9013388-2 1996 treatment with interferon (IFN)-alpha-2a (300 IU/g) significantly inhibited wet-dog shakes (WDS) induced by (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane (DOI; 0.5, 1.0 mg/kg), which is mediated by serotonin (5-hydroxytryptamine; 5-HT)2 receptor in rats. Serotonin 215-234 interferon alpha-3 Canis lupus familiaris 15-37 8812058-3 1996 Here we show that the normal differentiation of the serotonin neurons of the Drosophila nerve cord is dependent on the expression of two pattern formation genes, huckebein (hkb) and engrailed (en). Serotonin 52-61 huckebein Drosophila melanogaster 162-171 8812058-3 1996 Here we show that the normal differentiation of the serotonin neurons of the Drosophila nerve cord is dependent on the expression of two pattern formation genes, huckebein (hkb) and engrailed (en). Serotonin 52-61 huckebein Drosophila melanogaster 173-176 8845235-0 1995 Amylin-immunoreactivity is co-stored in a serotonin cell subpopulation of the vertebrate stomach and duodenum. Serotonin 42-51 islet amyloid polypeptide Homo sapiens 0-6 8845235-8 1995 Double and triple staining procedures on the same tissue section showed that almost all the amylin-immunoreactive cells present in the gastroduodenal region also co-stored serotonin and chromogranin A, and displayed argyrophilia in Grimelius impregnation. Serotonin 172-181 islet amyloid polypeptide Homo sapiens 92-98 8845235-9 1995 On the other hand, almost all the serotonin-immunoreactive cells of this region co-stored amylin, whereas those in more distal gut regions did not. Serotonin 34-43 islet amyloid polypeptide Homo sapiens 90-96 8845235-10 1995 This finding suggests that those amylin-containing cells correspond to a subtype of gastroduodenal serotonin cells. Serotonin 99-108 islet amyloid polypeptide Homo sapiens 33-39 8535398-1 1995 Characterization of the serotonin-induced increase in guanosine 3",5"-cyclic monophosphate (cyclic GMP) was investigated and compared with that induced by atrial natriuretic peptide (ANP) in NG108-15 cells. Serotonin 24-33 5'-nucleotidase, cytosolic II Mus musculus 99-102 8535398-2 1995 The cyclic GMP formed by serotonin or ANP was transported in a similar manner to the extracellular medium, although the cyclic GMP formed by bradykinin was not. Serotonin 25-34 5'-nucleotidase, cytosolic II Mus musculus 11-14 8535398-3 1995 Serotonin and ANP raised cyclic GMP additively. Serotonin 0-9 5'-nucleotidase, cytosolic II Mus musculus 32-35 8535398-4 1995 Serotonin-induced cyclic GMP formation was completely inhibited by pretreatment with 100 nM 12-o-tetradecanoylphorbol 13-acetate (TPA), although that induced by ANP was only partially inhibited and the effects were blocked by pretreatment with staurosporin. Serotonin 0-9 5'-nucleotidase, cytosolic II Mus musculus 25-28 8535398-6 1995 Serotonin-stimulated cyclic GMP formation was found to occur in neuroblastoma N18TG-2, but not in glioma C6Bu-1. Serotonin 0-9 5'-nucleotidase, cytosolic II Mus musculus 28-31 7629513-8 1995 These stable transfectants released serotonin in response to cross-linkage of Fc epsilon RI, demonstrating that the molecular defect of p161+/Fc epsilon RI- mast cells is indeed the loss of Fc epsilon RI gamma expression. Serotonin 36-45 Fc epsilon receptor Ia Homo sapiens 78-91 7792602-0 1995 Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Serotonin 49-58 monoamine oxidase A Mus musculus 94-98 7659296-3 1995 Basal levels of endogenous extracellular GLU and ASP were increased over 2-fold and 3-fold, respectively, following local administration of the selective 5-hydroxytryptamine (5-HT3) receptor agonist phenylbiguanide (300 microM). Serotonin 154-173 5-hydroxytryptamine receptor 3A Rattus norvegicus 175-190 7700379-4 1995 To address these issues, we have generated mutant mice lacking functional 5-HT2C receptors (previously termed 5-HT1C), prominent G-protein-coupled receptors that are widely expressed throughout the brain and spinal cord and which have been proposed to mediate numerous central nervous system (CNS) actions of serotonin. Serotonin 309-318 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 74-80 7700379-4 1995 To address these issues, we have generated mutant mice lacking functional 5-HT2C receptors (previously termed 5-HT1C), prominent G-protein-coupled receptors that are widely expressed throughout the brain and spinal cord and which have been proposed to mediate numerous central nervous system (CNS) actions of serotonin. Serotonin 309-318 5-hydroxytryptamine (serotonin) receptor 2C Mus musculus 110-116 7601444-1 1995 A novel serotonin receptor designated 5HT7 (genetic locus HTR7) was cloned in 1993. Serotonin 8-17 5-hydroxytryptamine receptor 7 Homo sapiens 58-62 8728551-0 1996 Role of 5-HT1A receptors in the effects of acute chronic fluoxetine on extracellular serotonin in the frontal cortex. Serotonin 85-94 5-hydroxytryptamine receptor 1A Rattus norvegicus 8-14 8723309-5 1996 It is speculated that NAG could be a marker for serotonin. Serotonin 48-57 O-GlcNAcase Homo sapiens 22-25 8769878-1 1996 The hph-1 mouse which displays tetrahydrobiopterin deficiency and impaired dopamine and serotonin turnover, has been used to study cofactor replacement therapy for disorders causing brain tetrahydrobiopterin deficiency. Serotonin 88-97 hyperphenylalaninemia 1 Mus musculus 4-9 8867723-1 1996 Serotonin (5-hydroxytryptamine, 5-HT) uptake, storage and metabolism in human megakaryoblastic cell line (Meg-01) which acts as a model for megakaryocyte precursors, megakaryoblasts were investigated by using biochemical (HPLC) and morphological (electron microscope, EM) techniques. Serotonin 0-9 protein tyrosine phosphatase non-receptor type 4 Homo sapiens 106-109 8547642-9 1996 Moreover, Sc-ABP1, Sc-ABP2, and gamma-actin inhibited Ca(2+)-induced release of serotonin in the absence of recombinant scinderin, suggesting an inhibition of platelet endogenous scinderin. Serotonin 80-89 amine oxidase copper containing 1 Homo sapiens 13-17 8522955-0 1996 Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 21-27 8833223-2 1996 The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin. Serotonin 140-159 pyridoxal (pyridoxine, vitamin B6) kinase Mus musculus 45-61 8833223-2 1996 The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin. Serotonin 140-159 pyridoxal (pyridoxine, vitamin B6) kinase Mus musculus 63-66 8833223-2 1996 The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin. Serotonin 161-165 pyridoxal (pyridoxine, vitamin B6) kinase Mus musculus 45-61 8833223-2 1996 The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin. Serotonin 161-165 pyridoxal (pyridoxine, vitamin B6) kinase Mus musculus 63-66 8825897-1 1995 The principal brain synaptic vesicular monoamine transporter (VMAT2) is responsible for the reuptake of serotonin, dopamine, norepinephrine, epinephrine, and histamine from the cytoplasm into synaptic vesicles, thus contributing to determination of the size of releasable neurotransmitter vesicular pools. Serotonin 104-113 solute carrier family 18 member A2 Homo sapiens 62-67 8581480-0 1995 Serotonin and stress-induced increases in renin secretion are not blocked by sympathectomy/adrenal medullectomy but are blocked by beta antagonists. Serotonin 0-9 renin Rattus norvegicus 42-47 7545820-0 1995 Gender and estrous cycle effects of the 5-HT1A agonist, 8-OH-DPAT, on hypothalamic serotonin. Serotonin 83-92 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-46 7478301-3 1995 In the present study, release of the false transmitter serotonin from the dopaminergic nerve terminals was studied by loading the neurons in vivo with serotonin precursor L-tryptophan and MAO inhibitor pargyline, which results in accumulation of false transmitter serotonin. Serotonin 55-64 monoamine oxidase A Rattus norvegicus 188-191 7562606-20 1995 Under current clamp, both 5-HT and 8-OH-DPAT decreased the amplitude of the after-hyperpolarization (AHP) that followed action potentials, indicating involvement of a 5-HT1A receptor. Serotonin 26-30 5-hydroxytryptamine receptor 1A Rattus norvegicus 167-173 7573767-5 1995 A hypothesis is presented which states that the elevated NAG levels found in some seizure patients could be associated with abnormalities of serotonin metabolism. Serotonin 141-150 O-GlcNAcase Homo sapiens 57-60 7714755-0 1995 (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. Serotonin 97-116 5-hydroxytryptamine receptor 2A Rattus norvegicus 158-164 7714755-0 1995 (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. Serotonin 97-116 5-hydroxytryptamine receptor 1A Rattus norvegicus 200-206 7714755-1 1995 In this study, the involvement of serotonergic and dopaminergic receptors in the modulation of the head-twitch (HTW) response to the 5-hydroxytryptamine (5-HT)2A/5-HT2C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, was characterized in rats using novel and selective ligands at 5-HT2A, 5-HT2C, D1, D2 and 5-HT1A receptors. Serotonin 133-152 5-hydroxytryptamine receptor 2A Rattus norvegicus 288-294 7714755-1 1995 In this study, the involvement of serotonergic and dopaminergic receptors in the modulation of the head-twitch (HTW) response to the 5-hydroxytryptamine (5-HT)2A/5-HT2C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, was characterized in rats using novel and selective ligands at 5-HT2A, 5-HT2C, D1, D2 and 5-HT1A receptors. Serotonin 133-152 5-hydroxytryptamine receptor 1A Rattus norvegicus 315-321 27517985-0 1997 Comparison of histamine and serotonin release from rat peritoneal mast cells induced by nerve growth factor and compound 48/80. Serotonin 28-37 nerve growth factor Rattus norvegicus 88-107 7749848-0 1995 Lysine modification of LDL or lipoprotein(a) by 4-hydroxynonenal or malondialdehyde decreases platelet serotonin secretion without affecting platelet aggregability and eicosanoid formation. Serotonin 103-112 lipoprotein(a) Homo sapiens 30-44 7749848-2 1995 LDL and lipoprotein(a) [Lp(a)] modified with secondary breakdown products of lipid peroxidation (4-hydroxy-2,3-trans-nonenal [HNE] 0.1 to 10 mmol/L or malondialdehyde [MDA] 1 to 50 mmol/L) induced neither spontaneous platelet aggregation nor secretion of 5-hydroxytryptamine (5-HT) from platelet aminestorage granules. Serotonin 255-274 lipoprotein(a) Homo sapiens 8-22 7749848-2 1995 LDL and lipoprotein(a) [Lp(a)] modified with secondary breakdown products of lipid peroxidation (4-hydroxy-2,3-trans-nonenal [HNE] 0.1 to 10 mmol/L or malondialdehyde [MDA] 1 to 50 mmol/L) induced neither spontaneous platelet aggregation nor secretion of 5-hydroxytryptamine (5-HT) from platelet aminestorage granules. Serotonin 255-274 lipoprotein(a) Homo sapiens 24-29 7749848-2 1995 LDL and lipoprotein(a) [Lp(a)] modified with secondary breakdown products of lipid peroxidation (4-hydroxy-2,3-trans-nonenal [HNE] 0.1 to 10 mmol/L or malondialdehyde [MDA] 1 to 50 mmol/L) induced neither spontaneous platelet aggregation nor secretion of 5-hydroxytryptamine (5-HT) from platelet aminestorage granules. Serotonin 276-280 lipoprotein(a) Homo sapiens 8-22 7749848-2 1995 LDL and lipoprotein(a) [Lp(a)] modified with secondary breakdown products of lipid peroxidation (4-hydroxy-2,3-trans-nonenal [HNE] 0.1 to 10 mmol/L or malondialdehyde [MDA] 1 to 50 mmol/L) induced neither spontaneous platelet aggregation nor secretion of 5-hydroxytryptamine (5-HT) from platelet aminestorage granules. Serotonin 276-280 lipoprotein(a) Homo sapiens 24-29 9048762-0 1997 Potentiation of the fluoxetine-induced increase in dialysate levels of serotonin (5-HT) in the frontal cortex of freely moving rats by combined blockade of 5-HT1A and 5-HT1B receptors with WAY 100,635 and GR 127,935. Serotonin 71-80 5-hydroxytryptamine receptor 1A Rattus norvegicus 156-173 9129181-0 1997 5-Hydroxytryptamine-induced Ca2+ -independent cGMP formation is mediated by nitric oxide in a nitric oxide synthase-independent manner in NG108-15 cells. Serotonin 0-19 nitric oxide synthase 1, neuronal Mus musculus 94-115 9258902-2 1997 MAO A and B activities were determined by measuring the rate of oxidation of the specific substrates phenethylamine and serotonin. Serotonin 120-129 monoamine oxidase A Mus musculus 0-5 9037433-9 1997 When the sections without inhibitor pretreatment were incubated with the type A preferential substrate serotonin, the MAO activity was strongly stained in LC neurons but very weakly in DR neurons. Serotonin 103-112 monoamine oxidase A Rattus norvegicus 118-121 9605843-3 1997 Serotonin is acetylated to N-acetylserotonin by serotonin N-acetyltransferase (SNAT) and then methylated to form melatonin by hydroxyindole-O-methyltransferase (HIOMT). Serotonin 0-9 acetylserotonin O-methyltransferase Mus musculus 126-159 9605843-3 1997 Serotonin is acetylated to N-acetylserotonin by serotonin N-acetyltransferase (SNAT) and then methylated to form melatonin by hydroxyindole-O-methyltransferase (HIOMT). Serotonin 0-9 acetylserotonin O-methyltransferase Mus musculus 161-166 9222755-5 1997 Compound heterozygous or homozygous mutations spread over all six exons encoding the 6-pyruvoyl-tetrahydropterin synthase cause an autosomal recessively inherited variant of hyperphenylalaninemia, mostly accompanied by a deficiency of dopamine and serotonin. Serotonin 248-257 6-pyruvoyltetrahydropterin synthase Homo sapiens 85-121 9404298-11 1997 The serotonin antagonist metergoline strongly suppresses plasma concentrations of prolactin in pseudopregnant dogs and decreases the clinical signs of pseudopregnancy. Serotonin 4-13 prolactin Canis lupus familiaris 82-91 9596862-1 1997 OBJECTIVE: To provide evidence to the hypothesis that the involvement of serotonin (5-HT) takes part in the pathogenesis of pregnancy induced hypertension (PIH). Serotonin 73-82 pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included) Homo sapiens 156-159 21153080-0 1996 Serotonin increases interleukin-6 release and decreases tumor necrosis factor release from rat adrenal zona glomerulosa cells in vitro. Serotonin 0-9 tumor necrosis factor-like Rattus norvegicus 56-77 21153080-6 1996 Serotonin (1-1000 nM) increased basal IL-6 release from zona glomerulosa cells, but inhibited basal TNF release from these cells. Serotonin 0-9 tumor necrosis factor-like Rattus norvegicus 100-103 21153080-8 1996 Serotonin potentiated IL-6 release stimulated by endotoxin and IL-1beta, but inhibited TNF release stimulated by these agents. Serotonin 0-9 tumor necrosis factor-like Rattus norvegicus 87-90 8933361-4 1996 The aim of this study was to assess whether, in rats, these two phenomena were regulated by serotonin, acting via 5-HT1A receptors. Serotonin 92-101 5-hydroxytryptamine receptor 1A Rattus norvegicus 114-120 8901578-4 1996 Here, we report the cloning of the corresponding aaNAT cDNA (aaNAT1) that upon COS cell expression acetylates dopamine, tryptamine, and the immediate melatonin precursor serotonin. Serotonin 170-179 Arylalkylamine N-acetyltransferase 1 Drosophila melanogaster 49-54 8901578-4 1996 Here, we report the cloning of the corresponding aaNAT cDNA (aaNAT1) that upon COS cell expression acetylates dopamine, tryptamine, and the immediate melatonin precursor serotonin. Serotonin 170-179 Arylalkylamine N-acetyltransferase 1 Drosophila melanogaster 61-67 8930380-8 1996 These results show that peripheral administration of serotonin agonists active at 5HT1a/5HT7 receptors mimic the dual effects of light on melatonin production in the rat and raise the possibility that serotonin pathways are more important in mediating the effects of retinally perceived light in the rat than previously believed. Serotonin 53-62 5-hydroxytryptamine receptor 1A Rattus norvegicus 82-87 8878539-0 1996 Cyclic GMP elevation by 5-hydroxytryptamine is due to nitric oxide derived from endogenous nitrosothiol in NG108-15 cells. Serotonin 24-43 5'-nucleotidase, cytosolic II Mus musculus 7-10 8930312-2 1996 By means of 5-hydroxyin-doleacetic acid (5-HIAA) voltammetric measurements, this study investigated their influence on serotonin metabolism which depends mainly upon the activity of monoamine oxidase type A. Serotonin 119-128 monoamine oxidase A Rattus norvegicus 182-206 8891297-0 1996 Augmented release of serotonin by adenosine A2a receptor activation and desensitization by CGS 21680 in the rat nucleus tractus solitarius. Serotonin 21-30 adenosine A2a receptor Rattus norvegicus 34-56 8891265-0 1996 Preprotachykinin and preproenkephalin mRNA expression within striatal subregions in response to altered serotonin transmission. Serotonin 104-113 tachykinin, precursor 1 Rattus norvegicus 0-16 8819525-2 1996 Electrophysiological studies have suggested that a subpopulation of gamma-aminobutyric acid (GABA)ergic interneurons in layer III of the rat piriform cortex are excited by serotonin (5-HT) via 5-HT2A receptors. Serotonin 172-181 5-hydroxytryptamine receptor 2A Rattus norvegicus 193-199 8873105-2 1996 It bound potently at serotonin 5-HT2, dopaminergic D2, serotonin 5-HT1A, and adrenergic alpha 1 and alpha 2 receptors. Serotonin 21-30 5-hydroxytryptamine receptor 1A Rattus norvegicus 65-71 8873105-2 1996 It bound potently at serotonin 5-HT2, dopaminergic D2, serotonin 5-HT1A, and adrenergic alpha 1 and alpha 2 receptors. Serotonin 55-64 5-hydroxytryptamine receptor 1A Rattus norvegicus 65-71 8883870-3 1996 The co-existence of 5-HT3R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT3R, can affect GABA release and suggests the participation of 5-HT3R in the inhibitory regulation of forebrain neurons. Serotonin 87-96 5-hydroxytryptamine receptor 3A Rattus norvegicus 20-26 8883870-3 1996 The co-existence of 5-HT3R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT3R, can affect GABA release and suggests the participation of 5-HT3R in the inhibitory regulation of forebrain neurons. Serotonin 87-96 5-hydroxytryptamine receptor 3A Rattus norvegicus 102-108 8883870-3 1996 The co-existence of 5-HT3R and GABA in cortical and hippocampal neurons indicates that serotonin, via 5-HT3R, can affect GABA release and suggests the participation of 5-HT3R in the inhibitory regulation of forebrain neurons. Serotonin 87-96 5-hydroxytryptamine receptor 3A Rattus norvegicus 102-108 8770136-2 1996 Serotonin (5-HT) interacts with TRH in the dorsal vagal complex (DVC) to augment gastric acid secretory responses. Serotonin 0-9 thyrotropin releasing hormone Rattus norvegicus 32-35 8650176-5 1996 Our data suggest that in the nervous system serotonin may negatively control IRK1 channel activity by direct PKA-mediated phosphorylation. Serotonin 44-53 potassium inwardly rectifying channel subfamily J member 2 Homo sapiens 77-81 8813537-2 1996 A subpopulation of interneurons in layer III of the rat piriform cortex that are excited by 5-hydroxytryptamine (5-HT) via 5-HT2A receptors are also excited by norepinephrine via alpha 1-adrenoceptors. Serotonin 92-111 5-hydroxytryptamine receptor 2A Rattus norvegicus 123-129 8632181-1 1996 The effects of systemic administration of the serotonin (5-hydroxytryptamine) 5-HT1A receptor agonists flesinoxan and 8-hydroxy-2-(di-n-propylamino)tetralin on extracellular 5-HT were measured using microdialysis probes in both median raphe nucleus and dorsal hippocampus. Serotonin 46-55 5-hydroxytryptamine receptor 1A Rattus norvegicus 78-84 8632181-1 1996 The effects of systemic administration of the serotonin (5-hydroxytryptamine) 5-HT1A receptor agonists flesinoxan and 8-hydroxy-2-(di-n-propylamino)tetralin on extracellular 5-HT were measured using microdialysis probes in both median raphe nucleus and dorsal hippocampus. Serotonin 57-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 78-84 8738296-1 1996 In a recent study, utilizing single cell recording techniques, we have shown that administration of 5-HT1A receptor antagonists, e.g. (S)-UH-301, to rats concomitantly treated, acute or chronically, with the selective serotonin reuptake inhibitor (SSRI) citalopram significantly increases the activity of 5-hydroxytryptamine (5-HT) containing neurons in the dorsal raphe nucleus (DRN). Serotonin 305-324 5-hydroxytryptamine receptor 1A Rattus norvegicus 100-106 8662278-1 1996 Two splice variants of the ligand-gated 5-hydroxytryptamine or serotonin 5-HT3 receptor that differ in a six-amino-acid deletion were cloned by polymerase chain reaction from the hippocampus x neuroblastoma cell line HN9.10e. Serotonin 40-59 MT-RNR2 like 9 (pseudogene) Homo sapiens 217-220 8660327-3 1996 Biochemical analysis revealed that serotonin (5-HT) and dopamine (DA) transmission was decreased in the cerebral cortex, the hippocampus, or the striatum of TN-knockout mouse brain. Serotonin 35-44 tenascin C Mus musculus 157-159 8621690-4 1996 Two domains of VMAT2, one extending from transmembrane domain (TMD) 5 to the beginning of TMD8 and the other from the end of TMD9 through TMD12, increase the affinity for serotonin and histamine as well as the sensitivity to tetrabenazine but only in the context of more C-terminal and more N-terminal VMAT2 sequences, respectively. Serotonin 171-180 solute carrier family 18 member A2 Homo sapiens 15-20 8621690-4 1996 Two domains of VMAT2, one extending from transmembrane domain (TMD) 5 to the beginning of TMD8 and the other from the end of TMD9 through TMD12, increase the affinity for serotonin and histamine as well as the sensitivity to tetrabenazine but only in the context of more C-terminal and more N-terminal VMAT2 sequences, respectively. Serotonin 171-180 solute carrier family 18 member A2 Homo sapiens 302-307 8598218-6 1996 PGHS-2 was barely detectable in resting cells but was inducible by PDGF-AB, PDGF-BB, serotonin, FCS, and calcium ionophore A23187. Serotonin 85-94 prostaglandin-endoperoxide synthase 2 Rattus norvegicus 0-6 8720485-6 1996 The results suggest that (1) the facilitation by dopamine and other modulators also occurs in recombinant ATP-receptor channels, and (2) the selective facilitation by dopamine, 5-hydroxytryptamine and divalent cations of P2x2-purinoceptor channels is attributed to some structural difference of the channels from P2x1-purinoceptor channels. Serotonin 177-196 purinergic receptor P2X 1 Rattus norvegicus 106-118 8720485-6 1996 The results suggest that (1) the facilitation by dopamine and other modulators also occurs in recombinant ATP-receptor channels, and (2) the selective facilitation by dopamine, 5-hydroxytryptamine and divalent cations of P2x2-purinoceptor channels is attributed to some structural difference of the channels from P2x1-purinoceptor channels. Serotonin 177-196 purinergic receptor P2X 1 Rattus norvegicus 313-317 8788487-1 1996 Studies of the affinities for serotonin 5-HT2A and 5-HT1A receptor subtypes of lysergic acid amides prepared from chiral 2-aminoalkanes showed a stereoselective preference at both receptor types for the amides with alkyl groups containing the R configuration. Serotonin 30-39 5-hydroxytryptamine receptor 1A Rattus norvegicus 51-57 8598478-0 1996 Secretion of IL-16 (lymphocyte chemoattractant factor) from serotonin-stimulated CD8+ T cells in vitro. Serotonin 60-69 interleukin 16 Homo sapiens 13-18 8598478-0 1996 Secretion of IL-16 (lymphocyte chemoattractant factor) from serotonin-stimulated CD8+ T cells in vitro. Serotonin 60-69 interleukin 16 Homo sapiens 20-53 8598478-7 1996 Neutralizing experiments with specific mAbs indicated that the serotonin-induced chemotactic factor was the previously characterized lymphocyte chemoattractant factor (LCF), recently designated IL-16. Serotonin 63-72 interleukin 16 Homo sapiens 133-166 8598478-7 1996 Neutralizing experiments with specific mAbs indicated that the serotonin-induced chemotactic factor was the previously characterized lymphocyte chemoattractant factor (LCF), recently designated IL-16. Serotonin 63-72 interleukin 16 Homo sapiens 168-171 8598478-7 1996 Neutralizing experiments with specific mAbs indicated that the serotonin-induced chemotactic factor was the previously characterized lymphocyte chemoattractant factor (LCF), recently designated IL-16. Serotonin 63-72 interleukin 16 Homo sapiens 194-199 8598478-8 1996 Serotonin induced secretion of IL-16 from CD8+, not CD4+, T cells which did not require the de novo protein synthesis. Serotonin 0-9 interleukin 16 Homo sapiens 31-36 8789602-10 1995 These data indicate that (1) different 5-HT receptor subtypes (5-HT1A and 5-HT1B) regulate dendritic and axon terminal 5-HT release; (2) serotonin release from the dendrites may be regulated by the voltage-sensitive N-type Ca2+ channels; (3) the 5-HT1A receptor-mediated inhibition of serotonin release may be due to opening of voltage-sensitive K+ channels. Serotonin 137-146 5-hydroxytryptamine receptor 1A Rattus norvegicus 63-80 7472476-0 1995 Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro. Serotonin 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 33-39 7595477-2 1995 We have analyzed the expression of the neuronal promoter of the AADC gene in cells synthesizing catecholamines and serotonin, as well as in non-AADC-expressing cells. Serotonin 115-124 dopa decarboxylase Rattus norvegicus 64-68 8606801-3 1995 Of the two vesicular monoamine transporters, histamine potently inhibits 3H-serotonin transport by one (VMAT2) but not the other (VMAT1). Serotonin 76-85 solute carrier family 18 member A2 Homo sapiens 104-109 8521904-9 1995 They further support the involvement of 5-HT (5-hydroxytryptamine, serotonin) systems in alcohol abuse and therapeutic interventions using 5-HT1A ligands. Serotonin 67-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 139-145 7477436-1 1995 Electrophysiological and autoradiographic approaches were used to assess possible changes in 5-hydroxytryptamine (serotonin) 5-HT1A receptors in the rat dorsal raphe nucleus after a subchronic treatment with fluoxetine or paroxetine, two specific serotonin reuptake inhibitors with antidepressant properties. Serotonin 93-112 5-hydroxytryptamine receptor 1A Rattus norvegicus 125-131 7477436-1 1995 Electrophysiological and autoradiographic approaches were used to assess possible changes in 5-hydroxytryptamine (serotonin) 5-HT1A receptors in the rat dorsal raphe nucleus after a subchronic treatment with fluoxetine or paroxetine, two specific serotonin reuptake inhibitors with antidepressant properties. Serotonin 114-123 5-hydroxytryptamine receptor 1A Rattus norvegicus 125-131 8566114-6 1995 [3H]YM060 binding was potently and stereospecifically inhibited by serotonin (5-HT)3 receptor agonists and antagonists. Serotonin 67-76 5-hydroxytryptamine receptor 3A Rattus norvegicus 78-93 7783131-6 1995 Additionally, these compounds had relatively high affinity for serotonin 5-HT1A and 5-HT2A, dopamine D2, and adrenergic alpha 1 receptors. Serotonin 63-72 5-hydroxytryptamine receptor 1A Rattus norvegicus 73-79 7791029-2 1995 Sarpogrelate, (R,S)-M-1, (R)-M-1 and (S)-M-1, respectively, were competitive antagonists of 5-hydroxytryptamine (5-HT) at 5-HT2A receptors of rat tail artery with calculated pA2 values of 8.53, 9.04, 9.00 and 8.81, respectively. Serotonin 92-111 5-hydroxytryptamine receptor 2A Rattus norvegicus 122-128 7651576-7 1995 In contrast to dopamine, the serotonin content in CAST striatum was reduced in proportion to the decrease in protein content. Serotonin 29-38 calpastatin Mus musculus 50-54 7885446-2 1995 5-Hydroxytryptamine (5-HT) modulates calcium-dependent K+ channels (KCa) responsible for the postspike afterhyperpolarization in different regions of the CNS. Serotonin 0-19 casein kappa Homo sapiens 68-71 7886454-3 1995 Mutations in the goa-1 gene, which encodes an alpha subunit of Go (G alpha o), cause behavioral defects similar to those observed in mutants that lack the neurotransmitter serotonin (5-HT), and goa-1 mutants are partially resistant to exogenous 5-HT. Serotonin 172-181 Guanine nucleotide-binding protein G(o) subunit alpha Caenorhabditis elegans 17-22 7768274-2 1995 ), a serotonin (5-hydroxytryptamine, 5-HT) releaser and re-uptake inhibitor, reduced the eating caused by neuropeptide Y (235 pmol) injected into the paraventricular nucleus of the hypothalamus. Serotonin 5-14 neuropeptide Y Homo sapiens 106-120 7620698-0 1995 Evidence that 5-hydroxytryptamine release in rat dorsal raphe nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. Serotonin 16-33 5-hydroxytryptamine receptor 1D Rattus norvegicus 106-112 7530742-8 1995 In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4. Serotonin 27-36 endothelin 1 Mus musculus 56-60 7530742-8 1995 In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4. Serotonin 27-36 endothelin 1 Mus musculus 252-256 7530742-8 1995 In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4. Serotonin 27-36 interleukin 4 Mus musculus 347-351 7530742-11 1995 Our results demonstrate that ET-1 can directly act as a histamine and serotonin secretagogue and as a stimulator of leukotriene C4 production in mast cells. Serotonin 70-79 endothelin 1 Mus musculus 29-33 7883264-4 1995 The liberation of CRH and ACTH is stimulated by the appetite suppressant, serotonin, and inhibited by the appetite-stimulating antagonist cyproheptadine and by glucocorticoids. Serotonin 74-83 corticotropin releasing hormone Homo sapiens 18-21 8584674-1 1995 Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Serotonin 67-76 monoamine oxidase A Homo sapiens 0-25 7704439-5 1994 Isoproterenol, dopamine, and serotonin all produced significant increments in LHRH secretion. Serotonin 29-38 gonadotropin releasing hormone 1 Mus musculus 78-82 7856324-7 1994 Plasma MHPG was linked to depressive symptoms (BPRS), and negative symptoms (SANS) were related to changes in the serum serotonin levels. Serotonin 120-129 USH1 protein network component sans Homo sapiens 77-81 7986202-2 1994 This study examined the role of plasma adenosine in the modulation of platelet-activating factor (PAF) activity on platelet aggregation and serotonin (5-HT) release in human platelet-rich plasma (PRP). Serotonin 140-149 PCNA clamp associated factor Homo sapiens 70-96 7846298-1 1994 In this study, the occurrence of 7B2, a highly conserved pituitary protein present in many neuroendocrine tissues and tumors, was investigated for the first time in the neuroendocrine cells (NEC) and neuroepithelial bodies (NEB) of hamster, rat and cat lung, as well as its colocalization with serotonin (5-HT) and calcitonin gene-related peptide (CGRP). Serotonin 294-303 secretogranin V Homo sapiens 33-36 7994200-8 1994 Serotonin itself and the agonist of 5-HT1A receptor through the activation of AA turnover counteract glutamate-induced inhibition of AA uptake into lipids of brain cortex. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 36-51 7952282-0 1994 Electrophysiological interactions between 5-hydroxytryptamine and thyrotropin releasing hormone on rat hippocampal CA1 neurons. Serotonin 42-61 carbonic anhydrase 1 Rattus norvegicus 115-118 8201323-9 1994 Further, the MA group exhibited increased basal intraplatelet serotonin concentrations (p < 0.0001) and increased serotonin secretion induced by both concentrations of collagen (p < 0.0001) and PAF (p < 0.001). Serotonin 117-126 PCNA clamp associated factor Homo sapiens 200-203 8170356-1 1994 Melatonin is synthesized from serotonin by the enzymes serotonin N-acetyltransferase (SNAT) and hydroxyindole-O-methyl-transferase (HIOMT). Serotonin 30-39 arylalkylamine N-acetyltransferase Mus musculus 55-84 8170356-1 1994 Melatonin is synthesized from serotonin by the enzymes serotonin N-acetyltransferase (SNAT) and hydroxyindole-O-methyl-transferase (HIOMT). Serotonin 30-39 arylalkylamine N-acetyltransferase Mus musculus 86-90 8290307-1 1994 Immunohistochemical and ligand-binding techniques were used to visualize the neurotransmitter serotonin and one of its receptors, the 5-HT1A subtype, in auditory nuclei of the brainstem. Serotonin 94-103 5-hydroxytryptamine receptor 1A Homo sapiens 134-140 8158981-7 1993 Increased brain PAF, dopamine, and and norepinephrine concentrations with decreased brain serotonin concentrations may mediate the hyperactivity of the hypothalamic-pituitary-adrenal axis and involve some unknown pathophysiologic processes of arenaviral infection. Serotonin 90-99 PCNA clamp associated factor Homo sapiens 16-19 8242348-2 1993 Activities of both MAOA and MAOB were significantly increased in frontal cortex and caudate nucleus, two brain regions shown previously to be the site of functional and morphological alterations of astrocytes and increased concentrations of the acid metabolites of dopamine and serotonin. Serotonin 278-287 monoamine oxidase A Homo sapiens 19-23 8219035-2 1993 The overflow of [3H]serotonin elicited by high potassium (30 mM) in superfused slices of rat hippocampus was significantly inhibited in the presence of two agonists, mu-selective [D-Ala2,N-methyl-Phe4,Gly5ol]enkephalin (DAGO) and delta-selective [D-Pen2,D-Pen5]enkephalin (DPDPE) in control animals. Serotonin 20-29 proenkephalin Rattus norvegicus 208-218 8219035-2 1993 The overflow of [3H]serotonin elicited by high potassium (30 mM) in superfused slices of rat hippocampus was significantly inhibited in the presence of two agonists, mu-selective [D-Ala2,N-methyl-Phe4,Gly5ol]enkephalin (DAGO) and delta-selective [D-Pen2,D-Pen5]enkephalin (DPDPE) in control animals. Serotonin 20-29 proenkephalin Rattus norvegicus 261-271 8374738-0 1993 Apparent regional differences in 5-HT1A binding may reflect [3H]8-OH-DPAT labeling of serotonin uptake sites. Serotonin 86-95 5-hydroxytryptamine receptor 1A Bos taurus 33-39 7685343-0 1993 In a concerted action kit ligand and interleukin 3 control the synthesis of serotonin in murine bone marrow-derived mast cells. Serotonin 76-85 kit ligand Mus musculus 22-32 7684475-2 1993 A granule membrane protein, granulophysin, has recently been identified in the membranes of platelet dense granules, organelles that contain stored ADP, ATP, serotonin, and calcium. Serotonin 158-167 CD63 molecule Homo sapiens 28-41 8390724-5 1993 Serotonin (5-HT) release was tested in platelet rich plasma (PRP) samples highly sensitive to PAF. Serotonin 0-9 PCNA clamp associated factor Homo sapiens 94-97 8058388-3 1993 Active immunization of the animals with a conjugated serotonin antigen, bovine serum albumin, reduces the LPO disorders induced by alcoholization. Serotonin 53-62 albumin Oryctolagus cuniculus 79-92 8454908-3 1993 Monocyte-induced inhibition of IFN-gamma production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxytryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Serotonin 88-97 5-hydroxytryptamine receptor 1A Homo sapiens 149-155 8454908-3 1993 Monocyte-induced inhibition of IFN-gamma production was abrogated by the biogenic amine serotonin, acting via the 5-hydroxytryptamine, or serotonin (5-HT1A), subset of serotonin receptors (5-HTR). Serotonin 138-147 5-hydroxytryptamine receptor 1A Homo sapiens 149-155 21043888-4 1993 FMet-Leu-Phe induced substantial increases in cytosolic calcium and 5-hydroxytryptamine release even in the presence of increasing amounts of citrated plasma, indicating that cathepsin G can stimulate platelets under conditions similar to those that may be encountered in vivo. Serotonin 68-87 cathepsin G Homo sapiens 175-186 1280285-6 1992 The density of serotonin positive varicosities increased slightly by P28, whereas substance P and enkephalin positive fibers increased considerably by this age. Serotonin 15-24 golgi SNAP receptor complex member 1 Rattus norvegicus 69-72 1280285-7 1992 Between P28 and the adult stage, the density of serotonin positive fibers decreased by about 50%. Serotonin 48-57 golgi SNAP receptor complex member 1 Rattus norvegicus 8-11 1359911-2 1992 GBL as well as dopamine D2 receptor selective drugs were shown not only to change neurochemical parameters of dopaminergic brain systems, but also to modulate serotonin metabolism without affecting its biosynthesis. Serotonin 159-168 MTOR associated protein, LST8 homolog Rattus norvegicus 0-3 1421524-7 1992 Additional markers included the immunoreactivities of dopamine-beta-hydroxylase (DBH), which is expressed by vagal crest-derived cells that colonize the bowel, neuropeptides (substance P and neuropeptide Y [NPY]) found in mature pancreatic neurons, and serotonin (5-HT), which is located in the cell bodies of enteric but not pancreatic neurons. Serotonin 253-262 dopamine beta-hydroxylase Rattus norvegicus 54-79 1421524-7 1992 Additional markers included the immunoreactivities of dopamine-beta-hydroxylase (DBH), which is expressed by vagal crest-derived cells that colonize the bowel, neuropeptides (substance P and neuropeptide Y [NPY]) found in mature pancreatic neurons, and serotonin (5-HT), which is located in the cell bodies of enteric but not pancreatic neurons. Serotonin 253-262 dopamine beta-hydroxylase Rattus norvegicus 81-84 1350353-0 1992 Gepirone, a selective serotonin (5HT1A) partial agonist in the treatment of major depression. Serotonin 22-31 5-hydroxytryptamine receptor 1A Homo sapiens 33-38 1413647-2 1992 Activity of MAO-A with serotonin as a substrate was statistically distinctly lower (by 22%) in placenta within early periods of pregnancy as compared which the mature placenta during the delivery time. Serotonin 23-32 monoamine oxidase A Homo sapiens 12-17 1585262-0 1992 5-Hydroxytryptamine increases excitability of CA1 hippocampal pyramidal cells. Serotonin 0-19 carbonic anhydrase 1 Rattus norvegicus 46-49 1585262-1 1992 In the presence of spiperone to block the 5-HT1A-mediated inhibition of pyramidal cell activity, 5-hydroxytryptamine (serotonin, 5-HT) produces a rapid transient increase in amplitude of the extracellularly recorded population spike from area CA1 of the hippocampus. Serotonin 97-116 carbonic anhydrase 1 Rattus norvegicus 243-246 1585262-1 1992 In the presence of spiperone to block the 5-HT1A-mediated inhibition of pyramidal cell activity, 5-hydroxytryptamine (serotonin, 5-HT) produces a rapid transient increase in amplitude of the extracellularly recorded population spike from area CA1 of the hippocampus. Serotonin 118-127 carbonic anhydrase 1 Rattus norvegicus 243-246 1323803-1 1992 In a previous study we showed that selective occupation of the mineralocorticoid receptor (MR) in hippocampal slices from adrenalectomized (ADX) rats attenuates the membrane hyperpolarization and resistance decrease induced in CA1 pyramidal neurons by serotonin (5HT). Serotonin 252-261 carbonic anhydrase 1 Rattus norvegicus 227-230 1323803-1 1992 In a previous study we showed that selective occupation of the mineralocorticoid receptor (MR) in hippocampal slices from adrenalectomized (ADX) rats attenuates the membrane hyperpolarization and resistance decrease induced in CA1 pyramidal neurons by serotonin (5HT). Serotonin 263-266 carbonic anhydrase 1 Rattus norvegicus 227-230 1635661-4 1992 Related experiments, using acetylcholinesterase (AChE) enzyme activity as a biochemical parameter, indicate that 5HT hastens the decline of enzyme activity. Serotonin 113-116 acetylcholinesterase Rattus norvegicus 27-47 1635661-4 1992 Related experiments, using acetylcholinesterase (AChE) enzyme activity as a biochemical parameter, indicate that 5HT hastens the decline of enzyme activity. Serotonin 113-116 acetylcholinesterase Rattus norvegicus 49-53 1493576-1 1992 After treatment of human platelets by a sulfhydryl-dependent bacterial protein cytolysin, a glycoprotein was reproducibly purified by a one-step affinity chromatography using 6-fluorotryptamine as ligand and elution by serotonin (5-HT), cyanoimipramine, citalopram, or a Na(+)-free buffer. Serotonin 219-228 perforin 1 Homo sapiens 79-88 1493576-1 1992 After treatment of human platelets by a sulfhydryl-dependent bacterial protein cytolysin, a glycoprotein was reproducibly purified by a one-step affinity chromatography using 6-fluorotryptamine as ligand and elution by serotonin (5-HT), cyanoimipramine, citalopram, or a Na(+)-free buffer. Serotonin 230-234 perforin 1 Homo sapiens 79-88 1425026-4 1992 Morphine induces the release of serotonin which either directly or indirectly via other neurotransmitters (e.g. dopamine) sensitizes LHRH neurons to the stimulatory effects of noradrenaline. Serotonin 32-41 gonadotropin releasing hormone 1 Rattus norvegicus 133-137 1545909-0 1992 Serotonin blocks the long-term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 87-90 1725889-6 1991 Serotonin (5-HT, 10(-8)-10(-5) M) elicited concentration-dependent contractions in both the HSV and RTA with EC50"s (-log concentration required to induce contractions 50% of maximal) of 6.31 +/- 0.03 and 6.55 +/- 0.06, respectively. Serotonin 0-9 MAS related GPR family member F Homo sapiens 100-103 1756387-7 1991 The findings show that the mechanism of action of adinazolam occurs simultaneously on presynaptic release mechanisms for norepinephrine and for serotonin in CA1 region of hippocampus. Serotonin 144-153 carbonic anhydrase 1 Rattus norvegicus 157-160 1837848-2 1991 Superfusion of either serotonin or 8-OH-DPAT in the bath was found to inhibit population responses in a dose-dependent manner in both regions, with a greater effect in the CA1. Serotonin 22-31 carbonic anhydrase 1 Rattus norvegicus 172-175 1652026-0 1991 Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity. Serotonin 24-33 5-hydroxytryptamine receptor 1A Homo sapiens 17-23 1652026-1 1991 1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine (NAN-190; 1a) is a putative postsynaptic 5-HT1A serotonin antagonist. Serotonin 105-114 5-hydroxytryptamine receptor 1A Homo sapiens 98-104 1922677-0 1991 Effects of active immunization against gonadotrophin-releasing hormone on the concentrations of noradrenaline, dopamine, 5-hydroxytryptamine and some of their metabolites in the brain and sexual organs of male rats. Serotonin 121-140 gonadotropin releasing hormone 1 Rattus norvegicus 39-70 1922677-1 1991 This is an investigation of the effects of active immunization against gonadotrophin-releasing hormone (GnRH) conjugated to keyhole limpet hemocyanin on brain and male sexual organ concentration of catecholamines and 5-hydroxytryptamine. Serotonin 217-236 gonadotropin releasing hormone 1 Rattus norvegicus 71-102 1922677-1 1991 This is an investigation of the effects of active immunization against gonadotrophin-releasing hormone (GnRH) conjugated to keyhole limpet hemocyanin on brain and male sexual organ concentration of catecholamines and 5-hydroxytryptamine. Serotonin 217-236 gonadotropin releasing hormone 1 Rattus norvegicus 104-108 1922677-4 1991 GnRH immunization also increased brain 5-hydroxytryptamine concentrations as observed in the hypothalamus, olfactory tubercles and striatum. Serotonin 39-58 gonadotropin releasing hormone 1 Rattus norvegicus 0-4 1861680-6 1991 This drug, and various quinones (e.g. acenaphthene-quinone) in BSA-conjugated forms also stimulated serotonin release from RBL cells sensitized with IgE(aDNP). Serotonin 100-109 activity-dependent neuroprotector homeobox Rattus norvegicus 153-157 1852219-0 1991 Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex. Serotonin 35-44 5-hydroxytryptamine receptor 1D Rattus norvegicus 99-105 1852219-16 1991 The serotonin axons of rat brain cortex may possess 5-HT1D in addition to 5-HT1B autoreceptors. Serotonin 4-13 5-hydroxytryptamine receptor 1D Rattus norvegicus 52-58 1862741-4 1991 Our results show that: a) KPP is 25-fold more active than BPP9a in potentiating rat paw edema elicited by BK: b) like BPP9a, KPP is specific in potentiating kinin-induced edema, being ineffective in potentiating edema induced by histamine or serotonin; and c) DesArg9-BK (DABK) elicits a small edematogenic response which can be potentiated by both KPP and BPP9a. Serotonin 242-251 keratin 10 Homo sapiens 125-128 1862741-4 1991 Our results show that: a) KPP is 25-fold more active than BPP9a in potentiating rat paw edema elicited by BK: b) like BPP9a, KPP is specific in potentiating kinin-induced edema, being ineffective in potentiating edema induced by histamine or serotonin; and c) DesArg9-BK (DABK) elicits a small edematogenic response which can be potentiated by both KPP and BPP9a. Serotonin 242-251 keratin 10 Homo sapiens 125-128 1786205-1 1991 The cloned 5-HT1A receptor, stably expressed in HeLa cells, has been shown to mediate the effects of 5-hydroxytryptamine (5-HT) to inhibit cAMP formation and to stimulate the hydrolysis of phosphatidylinositol. Serotonin 101-120 5-hydroxytryptamine receptor 1A Homo sapiens 11-26 1684905-0 1991 Serotonin initiation of delayed-type hypersensitivity: mediation by a primitive Thy-1+ antigen-specific clone or by specific monoclonal IgE antibody. Serotonin 0-9 Thy-1 cell surface antigen Homo sapiens 80-94 2133275-0 1990 Development of a sensitive and specific 14C-serotonin release assay for platelet-activating factor (PAF) in human neutrophils. Serotonin 44-53 PCNA clamp associated factor Homo sapiens 72-98 2133275-0 1990 Development of a sensitive and specific 14C-serotonin release assay for platelet-activating factor (PAF) in human neutrophils. Serotonin 44-53 PCNA clamp associated factor Homo sapiens 100-103 2133275-1 1990 A modified, sensitive and specific serotonin release assay has been developed for the routine determination of PAF in human neutrophils. Serotonin 35-44 PCNA clamp associated factor Homo sapiens 111-114 2133275-2 1990 PAF-mediated release of the serotonin from rabbit platelets served as the principle of the bioassay. Serotonin 28-37 PCNA clamp associated factor Homo sapiens 0-3 2133275-6 1990 A standard curve was prepared for the serotonin release with known amounts of PAF between 10 and 1000 fmol. Serotonin 38-47 PCNA clamp associated factor Homo sapiens 78-81 2264020-4 1990 In contrast, two other antibodies, named P14 and P34, themselves caused aggregation of rat platelets in platelet-rich plasma (PRP) and the secretion of 14C-serotonin from 14C-serotonin-labeled PRP. Serotonin 156-165 alpha- and gamma-adaptin binding protein Rattus norvegicus 49-52 2264020-4 1990 In contrast, two other antibodies, named P14 and P34, themselves caused aggregation of rat platelets in platelet-rich plasma (PRP) and the secretion of 14C-serotonin from 14C-serotonin-labeled PRP. Serotonin 175-184 alpha- and gamma-adaptin binding protein Rattus norvegicus 49-52 1979651-2 1990 In association with this technique micro carbon fibre electrodes (CFE) are able to separate ascorbic acid (Peak 1) from 3,4-dihydroxyphenylacetic acid (DOPAC) plus dopamine (DA) (Peak 2) and 5-hydroxyindoleacetic acid (5-HIAAA) plus serotonin (5-HT) (Peak 3) in vitro. Serotonin 233-242 pseudopodium-enriched atypical kinase 1 Mus musculus 107-113 1979651-2 1990 In association with this technique micro carbon fibre electrodes (CFE) are able to separate ascorbic acid (Peak 1) from 3,4-dihydroxyphenylacetic acid (DOPAC) plus dopamine (DA) (Peak 2) and 5-hydroxyindoleacetic acid (5-HIAAA) plus serotonin (5-HT) (Peak 3) in vitro. Serotonin 244-248 pseudopodium-enriched atypical kinase 1 Mus musculus 107-113 1689378-1 1990 The relationships between the concentration of serotonin (5-HT) and related metabolites in human blood and CSF have been studied. Serotonin 47-56 colony stimulating factor 2 Homo sapiens 107-110 33805130-5 2021 In the present paper we focus on the presentation of a new nanocarrier for clozapine and its use for targeted transport, enabling its interaction with the dopamine D2 and serotonin 5-HT1A heteromers (D2-5-HT1A) in the brain tissue. Serotonin 171-180 5-hydroxytryptamine receptor 1A Homo sapiens 181-187 33807811-3 2021 The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. Serotonin 81-100 5-hydroxytryptamine receptor 1A Homo sapiens 122-127 33588717-3 2021 OBJECTIVE: The aim of this study was to design, synthesize, and evaluate novel aminoalkanamides with serotonin 5-HT1A/5-HT7 receptor affinity and phosphodiesterase (PDE) inhibitory activity as a new approach to combat neurodegeneration and symptoms of Alzheimer"s disease. Serotonin 101-110 5-hydroxytryptamine receptor 1A Homo sapiens 111-117 10556680-0 1999 The serotonin precursor 5-hydroxytryptophan elevates serum leptin levels in mice. Serotonin 4-13 leptin Mus musculus 59-65 10556680-1 1999 The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice. Serotonin 17-26 leptin Mus musculus 81-87 10556680-1 1999 The effects of a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) on serum leptin levels were investigated in mice. Serotonin 28-32 leptin Mus musculus 81-87 7579165-5 1995 Serotonin or 5-hydroxytryptamine (5-HT), a stimulator of PI turnover, was also found to mimic the red light effect in enhancing NR transcript levels and inhibiting phyI transcript accumulation, indicating the role of the PI cycle in generating second messengers for regulating the two genes. Serotonin 0-9 nitrate reductase [NADH] 1 Zea mays 128-130 7579165-5 1995 Serotonin or 5-hydroxytryptamine (5-HT), a stimulator of PI turnover, was also found to mimic the red light effect in enhancing NR transcript levels and inhibiting phyI transcript accumulation, indicating the role of the PI cycle in generating second messengers for regulating the two genes. Serotonin 13-32 nitrate reductase [NADH] 1 Zea mays 128-130 34781023-8 2022 Overall, the data indicate that acute osmotic stress and air exposure that lowered catecholamine E and NE and elevated 5-HT levels could up-regulate mRNA expression of ERalpha and Vtg1 genes in the zebrafish brain, thus presenting evidence for a role of neurotransmitters on reproductive signals during acute conditional stress in the brain of wild zebrafish. Serotonin 119-123 vitellogenin 1 Danio rerio 180-184 34099307-8 2022 Selective serotonin reuptake inhibitors were prescribed at higher rates in the TAU arm compared to the GENE arm (p = .024). Serotonin 10-19 microtubule associated protein tau Homo sapiens 79-82 34966948-2 2021 We uncovered a novel neuroprotective mechanism involving interaction between neurotrophic factor-alpha1 (NF-alpha1/carboxypeptidase E, CPE) and human 5-HTR1E, a G protein-coupled serotonin receptor with no previously known neurological function. Serotonin 179-188 carboxypeptidase E Homo sapiens 135-138 34913624-7 2021 RESULTS: The stresses such as the mild repeated restraint stress suppressed alpha2AP expression in the hippocampus of mice, and the treatment of fluoxetine (selective serotonin reuptake inhibitor (SSRI)) recovered the stress-caused alpha2AP suppression. Serotonin 167-176 serine (or cysteine) peptidase inhibitor, clade F, member 2 Mus musculus 232-240 34924373-14 2022 The reduced viability of 3xTg-/-mice could indicate that 5-HT protects against the seizures that can impact the viability of APP/PS1 mice. Serotonin 57-61 presenilin 1 Mus musculus 129-132 34882257-1 2022 OBJECTIVES: This exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (TPH1) and aromatic l-amino acid decarboxylase (DDC), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (SB) diagnosed using audio-video polysomnography (vPSG) and compare them with that of individuals not presenting with SB. Serotonin 185-194 tryptophan hydroxylase 1 Homo sapiens 70-94 34882257-1 2022 OBJECTIVES: This exploratory research aimed to evaluate the levels of tryptophan hydroxylase 1 (TPH1) and aromatic l-amino acid decarboxylase (DDC), which play an important role in the serotonin synthesis pathway, in individuals with sleep bruxism (SB) diagnosed using audio-video polysomnography (vPSG) and compare them with that of individuals not presenting with SB. Serotonin 185-194 tryptophan hydroxylase 1 Homo sapiens 96-100 34453663-5 2021 Our research found enhanced expression of serotonin transporter and choline acetyltransferase in the hippocampus and hypothalamus in Shank3-deficient pups. Serotonin 42-51 SH3 and multiple ankyrin repeat domains 3 Mus musculus 133-139 34772352-0 2021 TPH1 gene polymorphism rs211105 is associated with serotonin and tryptophan hydroxylase 1 concentrations in acute pancreatitis patients. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 0-4 34510418-4 2021 5-HT1a receptors contribute to the depressive effect of 5-HT on inhibitory transmissions. Serotonin 56-60 5-hydroxytryptamine receptor 1A Homo sapiens 0-6 34510418-11 2021 Using slice patch-clamp recordings in combination with optogenetics, we found that 5-HT not only directly excited PVT neurons by activating 5-HT7 receptors to modulate hyperpolarization-activated cyclic nucleotide-gated (HCN) channels but also disinhibited these neurons by acting on presynaptic 5-HT1a receptors to reduce GABA inhibition. Serotonin 83-87 5-hydroxytryptamine receptor 1A Homo sapiens 296-302 34146705-4 2021 Compared to alpha-syn(A53T) single transgenic animals, pan-neuronal Abeta and alpha-syn(A53T) co-expression further enhanced the thrashing, egg laying, serotonin and cholinergic signaling deficits, and dopaminergic neuron damage in C. elegans. Serotonin 152-161 synuclein alpha Homo sapiens 12-21 34146705-4 2021 Compared to alpha-syn(A53T) single transgenic animals, pan-neuronal Abeta and alpha-syn(A53T) co-expression further enhanced the thrashing, egg laying, serotonin and cholinergic signaling deficits, and dopaminergic neuron damage in C. elegans. Serotonin 152-161 synuclein alpha Homo sapiens 78-87 34370152-9 2021 In addition, regarding liver genes, dietary treatment had a modulatory effect on the expression of Htr1aa and Htr2cl1 genes (encoding for serotonin receptors), TPH1a gene (encoding for tryptophan hydroxylase, the rate-limiting enzyme in the synthesis of serotonin from tryptophan), TOR gene (involved in protein synthesis), and Keap1 gene (involved in antioxidant responses). Serotonin 138-147 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 Danio rerio 110-117 34285037-0 2021 Over-production of gastrointestinal 5-HT promotes colitis-associated colorectal cancer progression via enhancing NLRP3 inflammasome activation. Serotonin 36-40 NLR family, pyrin domain containing 3 Mus musculus 113-118 34285037-4 2021 In this study, we found that 5-HT levels, as well as the expression of tryptophan hydroxylase 1 (TPH1), the 5-HT biosynthesis rate-limiting enzyme, were significantly upregulated in colorectal tumor tissues from CRC patients, CRC mouse models, and CRC cell lines, when compared with normal colorectal tissues or epithelial cell lines. Serotonin 108-112 tryptophan hydroxylase 1 Homo sapiens 71-95 34285037-4 2021 In this study, we found that 5-HT levels, as well as the expression of tryptophan hydroxylase 1 (TPH1), the 5-HT biosynthesis rate-limiting enzyme, were significantly upregulated in colorectal tumor tissues from CRC patients, CRC mouse models, and CRC cell lines, when compared with normal colorectal tissues or epithelial cell lines. Serotonin 108-112 tryptophan hydroxylase 1 Homo sapiens 97-101 34285037-7 2021 NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling. Serotonin 72-76 NLR family, pyrin domain containing 3 Mus musculus 0-5 34285037-7 2021 NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling. Serotonin 72-76 interleukin 1 alpha Mus musculus 28-35 34285037-7 2021 NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling. Serotonin 72-76 NLR family, pyrin domain containing 3 Mus musculus 187-192 34285037-7 2021 NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling. Serotonin 178-182 NLR family, pyrin domain containing 3 Mus musculus 0-5 34285037-7 2021 NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling. Serotonin 178-182 interleukin 1 alpha Mus musculus 28-35 34285037-7 2021 NLRP3 inflammasome mediated IL1beta maturation, and release upregulated 5-HT biosynthesis in CRC cells by inducing TPH1 transcription, revealing a positive feedback loop between 5-HT and NLRP3 signaling. Serotonin 178-182 NLR family, pyrin domain containing 3 Mus musculus 187-192 34396611-0 2021 In vivo brain levels of acetylcholine and 5-hydroxytryptamine after oleoylethanolamide or palmitoylethanolamide administrations are mediated by PPARalpha engagement. Serotonin 42-61 peroxisome proliferator activated receptor alpha Homo sapiens 144-153 34294372-8 2021 Only 5-CT, 8-OH-DPAT and L-694,247 (5-HT1/7, 5-HT1A and 5-HT1D agonists, respectively) mimicked 5-HT-induced inhibition, while alpha-methyl-5-HT (5-HT2 agonist) increased the vasopressor responses. Serotonin 96-100 5-hydroxytryptamine receptor 1D Rattus norvegicus 56-62 34294372-9 2021 The inhibitory effect of 5-HT was: a) no modified by SB269970 (5-HT7 antagonist); b) abolished by WAY-100,635 (5-HT1A antagonist) plus LY310762 (5-HT1D antagonist); and c) potentiated by ritanserin (5-HT2A receptor antagonist). Serotonin 25-29 5-hydroxytryptamine receptor 1D Rattus norvegicus 145-151 34423280-4 2021 egl-4 mutant males are also resistant to ventral tail curling induced by exogenous serotonin. Serotonin 83-92 cGMP-dependent protein kinase;cGMP-dependent protein kinase egl-4 Caenorhabditis elegans 0-5 34387135-1 2021 The pharmacologically characterized receptor subtype of the serotonin family, the 5HT1A receptor is implicated in the pathophysiology and treatment of depression and anxiety-related disorders. Serotonin 60-69 5-hydroxytryptamine receptor 1A Homo sapiens 82-96 34440174-9 2021 The results show that 5-HT is not involved in the development of oxaliplatin-induced allodynia, but increasing the activity of the 5-HT1A, 5-HT2A, and 5-HT3 receptors and decreasing the action of 5-HT2C and 5-HT6 receptors may help inhibit pain. Serotonin 22-26 5-hydroxytryptamine receptor 1A Homo sapiens 131-137 34369673-1 2021 OBJECTIVE: To observe the effect of electroacupuncture(EA) at "Zusanli"(ST36), "Yinlingquan" (SP9) or "Yingu"(KI10) on the expression of 5-hydroxytryptamine type 7 receptor (5-HT7R) in the gastric antrum and colon tissues in functional diarrhea (FD) model rats, so as to explore its mechanisms underlying improving FD. Serotonin 137-156 Sp9 transcription factor Rattus norvegicus 94-97 34282222-0 2021 Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin. Serotonin 134-143 methyl CpG binding protein 2 Mus musculus 27-32 34282222-0 2021 Fluoxetine increases brain MeCP2 immuno-positive cells in a female Mecp2 heterozygous mouse model of Rett syndrome through endogenous serotonin. Serotonin 134-143 methyl CpG binding protein 2 Mus musculus 67-72 34282222-3 2021 We recently found that fluoxetine, a selective serotonin (5-HT) reuptake inhibitor and antidepressant drug, fully rescued motor coordination deficits in Mecp2 heterozygous (Mecp2 HET) mice acting through brain 5-HT. Serotonin 210-214 methyl CpG binding protein 2 Mus musculus 153-158 34282222-3 2021 We recently found that fluoxetine, a selective serotonin (5-HT) reuptake inhibitor and antidepressant drug, fully rescued motor coordination deficits in Mecp2 heterozygous (Mecp2 HET) mice acting through brain 5-HT. Serotonin 210-214 methyl CpG binding protein 2 Mus musculus 173-178 34282222-7 2021 Inhibition of 5-HT synthesis abolished the fluoxetine-induced rise of MeCP2+ cells. Serotonin 14-18 methyl CpG binding protein 2 Mus musculus 70-75 34282222-8 2021 These findings suggest that boosting 5-HT transmission is sufficient to enhance the expression of MeCP2 in several brain regions of Mecp2 HET mice. Serotonin 37-41 methyl CpG binding protein 2 Mus musculus 98-103 34282222-8 2021 These findings suggest that boosting 5-HT transmission is sufficient to enhance the expression of MeCP2 in several brain regions of Mecp2 HET mice. Serotonin 37-41 methyl CpG binding protein 2 Mus musculus 132-137 34158618-5 2021 Here, we report that constitutive Cbln2 KO mice, but not Cbln1 KO mice, display robust compulsive behaviors, including stereotypic pattern running, marble burying, explosive jumping, and excessive nest building, and exhibit decreased brain serotonin levels. Serotonin 240-249 cerebellin 2 precursor protein Mus musculus 34-39 34158618-6 2021 Strikingly, treatment of Cbln2 KO mice with the serotonin precursor 5-hydroxytryptophan or the serotonin reuptake-inhibitor fluoxetine alleviated compulsive behaviors. Serotonin 48-57 cerebellin 2 precursor protein Mus musculus 25-30 34158618-6 2021 Strikingly, treatment of Cbln2 KO mice with the serotonin precursor 5-hydroxytryptophan or the serotonin reuptake-inhibitor fluoxetine alleviated compulsive behaviors. Serotonin 95-104 cerebellin 2 precursor protein Mus musculus 25-30 34306878-3 2021 This paper will review the evidence for attributing the risk of schizophrenia onset to early defects in serotonergic neurotransmission and explore the perspective of selective serotonin receptor inhibitor (SSRI) pharmacotherapy as a method of treatment and intervention for prodromal and ultra-high-risk patients by increasing 5-HT1A receptor sensitivity levels and modifying the transcription of 5-HT1A receptor-associated gene expression in these groups. Serotonin 176-185 5-hydroxytryptamine receptor 1A Homo sapiens 327-342 34306878-3 2021 This paper will review the evidence for attributing the risk of schizophrenia onset to early defects in serotonergic neurotransmission and explore the perspective of selective serotonin receptor inhibitor (SSRI) pharmacotherapy as a method of treatment and intervention for prodromal and ultra-high-risk patients by increasing 5-HT1A receptor sensitivity levels and modifying the transcription of 5-HT1A receptor-associated gene expression in these groups. Serotonin 176-185 5-hydroxytryptamine receptor 1A Homo sapiens 397-412 33993565-0 2021 Phenylalanine hydroxylase contributes to serotonin synthesis in mice. Serotonin 41-50 phenylalanine hydroxylase Mus musculus 0-25 33993565-6 2021 PAH contributes to serotonin levels in the blood, and may be important as a local source of serotonin in organs in which no other TPHs are expressed, such as liver and kidney. Serotonin 19-28 phenylalanine hydroxylase Mus musculus 0-3 33993565-6 2021 PAH contributes to serotonin levels in the blood, and may be important as a local source of serotonin in organs in which no other TPHs are expressed, such as liver and kidney. Serotonin 92-101 phenylalanine hydroxylase Mus musculus 0-3 7613100-0 1995 The effect of chronic treatment with imipramine on the responsiveness of hippocampal CA1 neurons to phenylephrine and serotonin in a chronic mild stress model of depression. Serotonin 118-127 carbonic anhydrase 1 Rattus norvegicus 85-88 7530742-4 1995 ET-1 induced a very rapid (< or = 1 min) and dose-dependent release of histamine and serotonin from BMMC cultured in the presence of both IL-3 and IL-4. Serotonin 88-97 endothelin 1 Mus musculus 0-4 7530742-4 1995 ET-1 induced a very rapid (< or = 1 min) and dose-dependent release of histamine and serotonin from BMMC cultured in the presence of both IL-3 and IL-4. Serotonin 88-97 interleukin 4 Mus musculus 150-154 7530742-5 1995 The effect of ET-1 was quantitatively comparable with IgE/Ag-induced mediator release and comprised up to 20% and 16% of total cellular histamine and serotonin, respectively. Serotonin 150-159 endothelin 1 Mus musculus 14-18 7712172-0 1995 Inhibition of epileptiform activity by serotonin in rat CA1 neurons. Serotonin 39-48 carbonic anhydrase 1 Rattus norvegicus 56-59 7712172-4 1995 Serotonin (20 microM) inhibited the directly evoked bursts of action potentials and caused a membrane hyperpolarization and decrease in membrane input resistance in untreated CA1 neurons. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 175-178 7756102-3 1995 With a separation of 1 week between sessions, volunteers received randomly one oral dose of each of the following compounds: 3 or 10 mg of the dopamine (DA2) receptor antagonist and serotonin (5HT1A) agonist DU 29894, 1 mg flesinoxan, 400 mg sulpiride, 3 mg haloperidol or placebo. Serotonin 182-191 5-hydroxytryptamine receptor 1A Homo sapiens 193-198 7552370-9 1995 Serotonin, acting on these receptors, should inhibit CA1 neurotransmitter release and, in this way, modulate subicular functions. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 53-56 7890832-0 1994 TrkA-immunoreactive profiles in the central nervous system: colocalization with neurons containing p75 nerve growth factor receptor, choline acetyltransferase, and serotonin. Serotonin 164-173 neurotrophic tyrosine kinase, receptor, type 1 Mus musculus 0-4 7961954-2 1994 Previous studies have shown that the production of interstitial collagenase by rat myometrial smooth muscle cells is dependent on serotonin. Serotonin 130-139 matrix metallopeptidase 1 Rattus norvegicus 51-75 7980635-0 1994 Serotonin inhibition of adenylate cyclase in human platelet membranes; relation to 5-HT-1A receptor-mediated activity. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 83-99 7519662-1 1994 Monoamine oxidase (MAO) A (EC 1.4.3.4) oxidizes norepinephrine and serotonin and is expressed in a cell type-specific manner. Serotonin 67-76 monoamine oxidase A Homo sapiens 0-25 7922584-1 1994 The effects of the serotonin (5-HT)3 receptor agonist, 2-methyl-5-hydroxytryptamine (2-methyl-5-HT), were studied in CA1 pyramidal cells of the rat hippocampus in vitro using the whole cell gigaseal technique. Serotonin 19-28 carbonic anhydrase 1 Rattus norvegicus 117-120 7527368-3 1994 Whole-blood and plasma serotonin and its metabolite 5-hydroxyindoleacetic acid were also higher in the stressed rats and whole-blood serotonin level showed a negative correlation with tPA in the stressed rats. Serotonin 133-142 plasminogen activator, tissue type Rattus norvegicus 184-187 8045595-0 1994 Interactions of IFN-gamma with IL-3 and IL-4 in the regulation of serotonin and arachidonate release from mouse peritoneal mast cells. Serotonin 66-75 interleukin 4 Mus musculus 40-44 8045595-4 1994 1% mast cells), IL-3 and IL-4 enhanced in an additive manner antigen-induced release of serotonin (5-HT), while IFN-gamma inhibited release regardless of whether IL-3 and/or IL-4 were present. Serotonin 88-97 interleukin 4 Mus musculus 25-29 8052414-1 1994 The effect of castration combined with either long-term treatment with the tricyclic antidepressant drug desipramine or the sex steroid 17 beta-estradiol on serotonin responses in area CA1 of the hippocampus of male and female rats was examined. Serotonin 157-166 carbonic anhydrase 1 Rattus norvegicus 185-188 7855226-1 1994 Previous studies with direct-acting serotonin (5-HT) agonists and antagonists have demonstrated that stimulation of 5-HT1A, 5-HT1C and 5-HT2 receptors may promote cortisol and prolactin (PRL) secretion in man. Serotonin 36-45 5-hydroxytryptamine receptor 1A Homo sapiens 116-122 7913394-6 1994 Serotonin depressed the facilitation of burst responses in slices pre-treated with AP-5 indicating that it also reduces the enhanced AMPA receptor mediated currents that occur during theta pattern stimulation. Serotonin 0-9 adaptor related protein complex 5 subunit beta 1 Homo sapiens 83-87 8155646-1 1994 Plasma membranes from Chinese hamster ovary (CHO) cells transfected with the serotonin 5-HT1A receptor have been incubated with full or partial receptor agonists and the photoreactive GTP analog, 4-azidoanilido-[alpha-32P]-GTP ([32P]-AA-GTP), to characterize the resulting receptor-G-protein interactions. Serotonin 77-86 5-hydroxytryptamine receptor 1A Homo sapiens 87-102 7511553-7 1994 The mucosal cells that expressed CRH mRNA also immunostained with anti-5-hydroxytryptamine antibody. Serotonin 73-90 corticotropin releasing hormone Homo sapiens 33-36 8199791-6 1994 Within the limitations that attend the use of buspirone as a 5-HT1A probe, our data suggest that the decrement in serotonin neurotransmission at post-synaptic 5-HT1A receptors in depression is due to decreased serotonin release rather than impaired responsivity of post-synaptic 5-HT1A receptors. Serotonin 114-123 5-hydroxytryptamine receptor 1A Homo sapiens 159-165 8199791-6 1994 Within the limitations that attend the use of buspirone as a 5-HT1A probe, our data suggest that the decrement in serotonin neurotransmission at post-synaptic 5-HT1A receptors in depression is due to decreased serotonin release rather than impaired responsivity of post-synaptic 5-HT1A receptors. Serotonin 114-123 5-hydroxytryptamine receptor 1A Homo sapiens 159-165 8199791-6 1994 Within the limitations that attend the use of buspirone as a 5-HT1A probe, our data suggest that the decrement in serotonin neurotransmission at post-synaptic 5-HT1A receptors in depression is due to decreased serotonin release rather than impaired responsivity of post-synaptic 5-HT1A receptors. Serotonin 210-219 5-hydroxytryptamine receptor 1A Homo sapiens 159-165 8199791-6 1994 Within the limitations that attend the use of buspirone as a 5-HT1A probe, our data suggest that the decrement in serotonin neurotransmission at post-synaptic 5-HT1A receptors in depression is due to decreased serotonin release rather than impaired responsivity of post-synaptic 5-HT1A receptors. Serotonin 210-219 5-hydroxytryptamine receptor 1A Homo sapiens 159-165 7984271-1 1994 The influence of cocaine exposure on serotonergic neurons and postsynaptic 5-HT1A receptor-mediated responses was evaluated by measuring neuroendocrine responses to a serotonin (5-HT) releaser or a 5-HT1A agonist. Serotonin 167-176 5-hydroxytryptamine receptor 1A Homo sapiens 75-81 7850356-1 1994 The work described in this article is concerned with the role of the 5-HT1a receptor in mediating the neurotrophic effects of serotonin, principally through the release of the substance S-100 beta from astroglial cells. Serotonin 126-135 5-hydroxytryptamine receptor 1A Homo sapiens 69-84 8122400-1 1994 Increase of serotonin content and decrease in 5-hydroxyindolyl acetic acid (5-HIAA) were observed under hypoxic conditions (9,000 m, 3 hrs) which correlated with inhibition of monoamine oxidase A. Serotonin 12-21 monoamine oxidase A Homo sapiens 176-195 8253745-4 1993 KCl-induced depolarization also stimulated a dose- and Ca(2+)-dependent [3H]serotonin release that in the GLC8 cell line was effectively inhibited by Ca2+ channel antagonists (Cd2+, nitrendipine, verapamil, omega-conotoxin GVIA, and omega-agatoxin IVA) and potentiated by the Ca2+ channel agonist BayK8644. Serotonin 76-85 CD2 molecule Homo sapiens 176-179 8263778-0 1993 Differential blockade by tachykinin NK1 and NK2 receptor antagonists of bronchoconstriction induced by direct-acting agonists and the indirect-acting mimetics capsaicin, serotonin and 2-methyl-serotonin in the anesthetized guinea pig. Serotonin 170-179 substance-K receptor Cavia porcellus 44-56 8295719-1 1993 Serotonin is one of the neurotransmitters which participates in the regulation of gonadotropin-releasing hormone (GnRH) release from the hypothalamus. Serotonin 0-9 gonadotropin releasing hormone 1 Rattus norvegicus 82-112 8295719-1 1993 Serotonin is one of the neurotransmitters which participates in the regulation of gonadotropin-releasing hormone (GnRH) release from the hypothalamus. Serotonin 0-9 gonadotropin releasing hormone 1 Rattus norvegicus 114-118 8295719-2 1993 In order to test the hypothesis that serotonin acts directly on the GnRH neurons, dual in situ hybridization with 35S-labeled cRNA probes encoding for the serotonin receptor subtypes-1a, -1c, or -2 together with digoxigenin-labeled GnRH cRNA probes was applied to histological sections of the septum-diagonal band and preoptic area. Serotonin 37-46 gonadotropin releasing hormone 1 Rattus norvegicus 68-72 8295719-4 1993 It is therefore suggested that the effects of serotonin on GnRH release are not mediated by direct actions of the neurotransmitter through serotonin-1a, -1c or -2 receptors on GnRH neurons but instead through other, yet unidentified serotonin receptor subtypes or through non-serotoninergic intermediary neurons. Serotonin 46-55 gonadotropin releasing hormone 1 Rattus norvegicus 59-63 8295719-4 1993 It is therefore suggested that the effects of serotonin on GnRH release are not mediated by direct actions of the neurotransmitter through serotonin-1a, -1c or -2 receptors on GnRH neurons but instead through other, yet unidentified serotonin receptor subtypes or through non-serotoninergic intermediary neurons. Serotonin 46-55 gonadotropin releasing hormone 1 Rattus norvegicus 176-180 7905821-7 1993 Pharmacological investigations with these ligands revealed that serotonin is probably involved in the behavioural disorders associated with schizophrenia through its binding to three distinct classes of receptors: 5-HT1A, 5-HT2 (or the closely related class 5-HT1C) and 5-HT3. Serotonin 64-73 5-hydroxytryptamine receptor 1A Homo sapiens 214-220 8410958-3 1993 Brain serotonin turnover as indicated by CSF 5-HIAA concentration does not correlate with CSF free testosterone concentration. Serotonin 6-15 colony stimulating factor 2 Homo sapiens 41-44 8274697-0 1993 [The effect of interleukin-2 on rosette formation and its dependence on the serotonin level]. Serotonin 76-85 interleukin 2 Mus musculus 15-28 8274697-4 1993 These data attest to the relationship of serotonin and IL-2 in the process of immunomodulation and to the importance of the balance of the substances in the environment at the moment of exposure to the antigenic information. Serotonin 41-50 interleukin 2 Mus musculus 55-59 8401931-2 1993 [3H]-5-hydroxytryptamine (5-HT) has been shown to radiolabel at least five types of 5-HT binding sites in mammalian brain tissue, 5-HT1A, 5-HT1C, 5-HT1D and 5-HT1D and 5-HT1E (Frazer et al., 1990). Serotonin 5-24 5-hydroxytryptamine receptor 1A Homo sapiens 130-136 19912938-4 1993 The other two activities were characterized as arylalkylamine N-acetyltransferase based on their preference for arylalkylamines such as serotonin and tryptamine. Serotonin 136-145 aralkylamine N-acetyltransferase Rattus norvegicus 47-81 8247943-7 1993 A correlation between the fall in platelet serotonin content and changes in tissue plasminogen activator and PAI activities was found (r = 0.55, p < 0.01 respectively). Serotonin 43-52 serpin family E member 1 Homo sapiens 109-112 7686941-3 1993 SCF induced serotonin release from rat peritoneal mast cells, connective tissue-type mast cells. Serotonin 12-21 KIT ligand Rattus norvegicus 0-3 8361583-8 1993 These results indicate that enkephalin (i) participates in the pathophysiology of spinal cord trauma and (ii) suggest that the peptide is somehow functionally related with serotonin. Serotonin 172-181 proenkephalin Rattus norvegicus 28-38 8462457-3 1993 Treatment of fibroblasts with 1 microM serotonin transiently increased bFGF mRNA levels about 3-fold compared to the level in control cells maintained in serum-free medium with 0.25% BSA and decreased IGF-I mRNA levels by approximately 50% compared to the level in control cells. Serotonin 39-48 insulin-like growth factor 1 Rattus norvegicus 201-206 8462457-6 1993 The effects of serotonin, bradykinin, and PMA on bFGF and IGF-I mRNA levels were abrogated by preincubation of cells in 250 nM PMA to down-regulate protein kinase-C. Serotonin 15-24 insulin-like growth factor 1 Rattus norvegicus 58-63 8478989-1 1993 The action of 5-hydroxytryptamine (5HT) on nicotinic acetylcholine receptor (nAChR) channels was investigated in mouse myotubes, human cloned TE671/RD cells, and Xenopus laevis oocytes. Serotonin 14-33 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 43-75 8478989-1 1993 The action of 5-hydroxytryptamine (5HT) on nicotinic acetylcholine receptor (nAChR) channels was investigated in mouse myotubes, human cloned TE671/RD cells, and Xenopus laevis oocytes. Serotonin 14-33 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 77-82 8478989-1 1993 The action of 5-hydroxytryptamine (5HT) on nicotinic acetylcholine receptor (nAChR) channels was investigated in mouse myotubes, human cloned TE671/RD cells, and Xenopus laevis oocytes. Serotonin 35-38 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 43-75 8478989-1 1993 The action of 5-hydroxytryptamine (5HT) on nicotinic acetylcholine receptor (nAChR) channels was investigated in mouse myotubes, human cloned TE671/RD cells, and Xenopus laevis oocytes. Serotonin 35-38 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 77-82 8478989-7 1993 It is concluded that the regulation of ACh responses by 5HT results from a fast noncompetitive blocking action of nAChR-channels. Serotonin 56-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 114-119 7680751-3 1993 Within these hydrophobic regions, this receptor was found to be 41-36% identical to the following serotonin [5-hydroxytryptamine (5-HT)] receptors: 5-HT2 > 5-HT1D > 5-HT1C > 5-HT1B > 5-HT1A > 5-HT1E. Serotonin 98-107 5-hydroxytryptamine receptor 1D Rattus norvegicus 159-165 8534141-0 1993 The somatostatin effect on the turnover of serotonin after the stimulation and blocking of the histamine H2 receptor in the rat"s brain. Serotonin 43-52 histamine receptor H 2 Rattus norvegicus 95-116 8274762-4 1993 In addition, we have found that photic responses of cells in the intergeniculate leaflet (which projects to the SCN) and of SCN cells are modulated by serotonin (5-HT) via a receptor that resembles the 5-HT1A subtype. Serotonin 151-160 5-hydroxytryptamine receptor 1A Homo sapiens 202-208 8255408-0 1993 Lowering of body core temperature by exposure to a cold environment and by a 5-HT1A agonist: effects on physiological and psychological variables and blood serotonin levels. Serotonin 156-165 5-hydroxytryptamine receptor 1A Homo sapiens 77-83 7680787-4 1993 Serotonin release was reduced by the systemic administration of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 68-83 1279842-0 1992 Ischemia-induced extracellular release of serotonin plays a role in CA1 neuronal cell death in rats. Serotonin 42-51 carbonic anhydrase 1 Rattus norvegicus 68-71 1279842-1 1992 BACKGROUND AND PURPOSE: Serotonin, via 5-HT2 receptors, exerts an excitatory effect on CA1 neurons and may play a role in ischemia-induced excitotoxic damage. Serotonin 24-33 carbonic anhydrase 1 Rattus norvegicus 87-90 1356432-6 1992 These studies indicate that, in addition to the dopamine system, the norepinephrine and serotonin systems also play prominent roles in the activation of zif268 and c-fos by cocaine and amphetamine. Serotonin 88-97 early growth response 1 Homo sapiens 153-159 1511304-0 1992 Serotonin preferentially hyperpolarizes capsaicin-sensitive C type sensory neurons by activating 5-HT1A receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 97-103 1524723-1 1992 The procedure for measuring the brain serotonin synthesis rate in living brain using labelled alpha-methyl-L-tryptophan (alpha-MTrp), a tryptophan analog, is described. Serotonin 38-47 lysosomal protein transmembrane 4 alpha Homo sapiens 127-131 1524723-3 1992 One advantage of this method is that alpha-MTrp is converted in situ into a serotonin tracer, alpha-methyl serotonin, and should be distributed into the same compartments as serotonin. Serotonin 76-85 lysosomal protein transmembrane 4 alpha Homo sapiens 43-47 1524723-3 1992 One advantage of this method is that alpha-MTrp is converted in situ into a serotonin tracer, alpha-methyl serotonin, and should be distributed into the same compartments as serotonin. Serotonin 107-116 lysosomal protein transmembrane 4 alpha Homo sapiens 43-47 1359073-1 1992 Procarbazine (N-isopropyl-alpha-(2-methyl hydrazino)-p-toluamide hydrochloride) inhibited more powerfully the deamination of benzylamine by semicarbazide-sensitive amine oxidase (SSAO) of rat brown adipose tissue than the deamination of 5-hydroxytryptamine and benzylamine by rat liver monoamine oxidase-A or -B activities, respectively. Serotonin 237-256 amine oxidase, copper containing 3 Rattus norvegicus 140-177 1321958-1 1992 Inhibition of [3H]-5-hydroxytryptamine ([3H]-5-HT) release from guinea pig brain slices via activation of the terminal 5-HT autoreceptor has previously been characterised as a model of 5-HT1D receptor activation, based on the rank potencies of a range of agonists, and the potent antagonism of the inhibitory effects of 5-HT by metitepine. Serotonin 19-38 5-hydroxytryptamine receptor 1D Cavia porcellus 185-200 1533667-6 1992 Pretreatment with S(-)propranolol or ketanserin also attenuated serotonin-induced contraction, demonstrating that serotonin mediates contraction through both 5-HT1A and 5-HT2 receptors in bovine large coronary arteries. Serotonin 64-73 5-hydroxytryptamine receptor 1A Bos taurus 158-170 1533667-6 1992 Pretreatment with S(-)propranolol or ketanserin also attenuated serotonin-induced contraction, demonstrating that serotonin mediates contraction through both 5-HT1A and 5-HT2 receptors in bovine large coronary arteries. Serotonin 114-123 5-hydroxytryptamine receptor 1A Bos taurus 158-170 1356248-0 1992 The effects of pertussis toxin on dopamine D2 and serotonin 5-HT1A autoreceptor-mediated inhibition of neurotransmitter synthesis: relationship to receptor reserve. Serotonin 50-59 5-hydroxytryptamine receptor 1A Homo sapiens 60-66 1356248-3 1992 Completely analogous effects were found at the somatodendritic 5-HT1A autoreceptor in the raphe nuclei, mediating inhibition of the synthesis of serotonin (5-HT); the full agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the partial agonist, buspirone were utilized to inhibit the synthesis of 5-HT, as measured by changes in levels of L-5-hydroxytryptophan (5-HTP). Serotonin 145-154 5-hydroxytryptamine receptor 1A Homo sapiens 63-69 1589591-7 1992 It was noted that the IAP suppressed the cyclic AMP production by 5HT, VIP and Forskolin. Serotonin 66-69 magnesium transporter 1 Rattus norvegicus 22-25 1349516-2 1992 Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase). Serotonin 209-218 butyrylcholinesterase Homo sapiens 68-89 1349516-2 1992 Amniotic fluid cholinesterases (mixture of acetylcholinesterase and butyrylcholinesterase) purified by procainamide-Sepharose affinity chromatography exhibited aryl acylamidase activity which was sensitive to serotonin inhibition (a property of aryl acylamidases associated with both acetyl- and butyrylcholinesterases) and tyramine activation (shown exclusively by aryl acylamidase associated with butyrylcholinesterase). Serotonin 209-218 butyrylcholinesterase Homo sapiens 296-317 1732716-1 1992 The relationship between the serotonin 5-hydroxytryptamine1B (5-HT1B) and 5-HT1D receptors has been the topic of much investigation and speculation since their complementary species distribution was first appreciated. Serotonin 29-38 5-hydroxytryptamine receptor 1D Rattus norvegicus 74-80 1355301-4 1992 Aryl-piperazine derivatives work as 5-HT1A receptor partial agonists and are known as serotonin normalizers. Serotonin 86-95 5-hydroxytryptamine receptor 1A Homo sapiens 36-51 1719253-5 1991 In addition a group of periacinar 5-hydroxytryptamine-immunoreactive cells and ganglia containing acetylcholinesterase, dopamine beta-hydroxylase and all of the peptides studied except somatostatin were identified. Serotonin 34-53 dopamine beta-hydroxylase Homo sapiens 120-145 1741773-8 1991 The ratio, MAO A molecular activity:MAO B molecular activity decreased in the order: serotonin (35:1) greater than tryptamine (12:1) greater than tyramine (3.3:1) greater than dopamine (2.4:1) greater than benzylamine (1:23). Serotonin 85-94 monoamine oxidase A Homo sapiens 11-16 1761282-0 1991 Studies on facial temperature rise and involvement of serotonin in the respiratory stimulation by CRH. Serotonin 54-63 corticotropin releasing hormone Homo sapiens 98-101 1761282-7 1991 administration of 100 micrograms hCRH in 10 healthy subjects pretreated with the serotonin antagonist cyproheptadine. Serotonin 81-90 corticotropin releasing hormone Homo sapiens 33-37 1687746-0 1991 Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 52-55 1687746-18 1991 These results suggest that serotonin directly excites GABAergic interneurones acting on a 5-HT3 receptor and consequently increasing the frequency of inhibitory synaptic events recorded in CA1 pyramidal cells. Serotonin 27-36 carbonic anhydrase 1 Rattus norvegicus 189-192 1868238-5 1991 We demonstrated for the first time that inhibition of aggregation and serotonin release, due to EDRF/NO, occurred in parallel. Serotonin 70-79 alpha hemoglobin stabilizing protein Homo sapiens 96-100 1869915-0 1991 Mineralocorticoid hormones suppress serotonin-induced hyperpolarization of rat hippocampal CA1 neurons. Serotonin 36-45 carbonic anhydrase 1 Rattus norvegicus 91-94 1653392-1 1991 We have previously shown that serotonin (5-HT) is a potent stimulator of corticosterone and aldosterone secretion by frog adrenocortical cells and we have demonstrated that the action of 5-HT is not mediated by the classical 5-HT receptor subtypes i.e. 5-HT1, 5-HT2 and 5-HT3. Serotonin 30-39 5-hydroxytryptamine receptor 2A Canis lupus familiaris 260-265 1707147-2 1991 We measured serotonin and its major metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA), in the C-1 to C-7, T-1 to T-6, T-7 to T-12, and T-13 to L-3 spinal segments of tumor-free and tumor-bearing rats. Serotonin 12-21 complement C2 Rattus norvegicus 95-105 2055324-3 1991 Inhibition of erythropoiesis is due to delay of erythropoietin biosynthesis by serotonin. Serotonin 79-88 erythropoietin Rattus norvegicus 48-62 2055324-4 1991 A problem on two-fold serotonin effect is under discussion: on the one hand, serotonin inhibits the erythropoietin formation and delays erythropoiesis, on the other hand, it intensifies the effect of ready erythropoietin on the developing bone marrow erythroid cells. Serotonin 22-31 erythropoietin Rattus norvegicus 100-114 2055324-4 1991 A problem on two-fold serotonin effect is under discussion: on the one hand, serotonin inhibits the erythropoietin formation and delays erythropoiesis, on the other hand, it intensifies the effect of ready erythropoietin on the developing bone marrow erythroid cells. Serotonin 22-31 erythropoietin Rattus norvegicus 206-220 2055324-4 1991 A problem on two-fold serotonin effect is under discussion: on the one hand, serotonin inhibits the erythropoietin formation and delays erythropoiesis, on the other hand, it intensifies the effect of ready erythropoietin on the developing bone marrow erythroid cells. Serotonin 77-86 erythropoietin Rattus norvegicus 100-114 2055324-4 1991 A problem on two-fold serotonin effect is under discussion: on the one hand, serotonin inhibits the erythropoietin formation and delays erythropoiesis, on the other hand, it intensifies the effect of ready erythropoietin on the developing bone marrow erythroid cells. Serotonin 77-86 erythropoietin Rattus norvegicus 206-220 2038073-6 1991 When endothelium is damaged, the absence of EDRF and prostacyclin at the site leads to platelet aggregation with the release, among other substances, of serotonin (5HT) and thromboxane A2. Serotonin 153-162 alpha hemoglobin stabilizing protein Homo sapiens 44-48 2038073-6 1991 When endothelium is damaged, the absence of EDRF and prostacyclin at the site leads to platelet aggregation with the release, among other substances, of serotonin (5HT) and thromboxane A2. Serotonin 164-167 alpha hemoglobin stabilizing protein Homo sapiens 44-48 2030808-3 1991 Serotonin is taken up and destroyed by the endothelial cells; these cells also release endothelium-derived relaxing factor (EDRF) when exposed to the monoamine. Serotonin 0-9 alpha hemoglobin stabilizing protein Homo sapiens 87-122 2030808-3 1991 Serotonin is taken up and destroyed by the endothelial cells; these cells also release endothelium-derived relaxing factor (EDRF) when exposed to the monoamine. Serotonin 0-9 alpha hemoglobin stabilizing protein Homo sapiens 124-128 1775595-3 1991 DMI also inhibited norepinephrine (NE) and serotonin (5-HT) stimulated 3H-IP1 formation in rat cerebral cortex. Serotonin 43-52 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 74-77 1775595-3 1991 DMI also inhibited norepinephrine (NE) and serotonin (5-HT) stimulated 3H-IP1 formation in rat cerebral cortex. Serotonin 54-58 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 74-77 2117776-5 1990 The effects of serotonin on baseline and IL-2-activated NK cells were mimicked by the 5-HT1A receptor-specific agonists 8-OH-DPAT and (+)-ALK. Serotonin 15-24 5-hydroxytryptamine receptor 1A Homo sapiens 86-101 2117776-6 1990 Our data suggest that serotonin regulates NK-cell responsiveness to IL-2 via 5-HT1A receptors. Serotonin 22-31 5-hydroxytryptamine receptor 1A Homo sapiens 77-83 2360620-3 1990 The concentrations of cathepsin G recovered by titration of the enzymatic activity correlate with the capability of these supernatants to induce platelet stimulation as measured by serotonin release. Serotonin 181-190 cathepsin G Homo sapiens 22-33 2360620-4 1990 Cathepsin G purified from neutrophil granules triggered platelet aggregation and serotonin release independent of arachidonic acid metabolites and platelet-activating factor formation. Serotonin 81-90 cathepsin G Homo sapiens 0-11 2357557-11 1990 The raphe grafts produced mainly a serotonin innervation, of both acetylcholinesterase- and serotonin-positive fibres. Serotonin 35-44 acetylcholinesterase Rattus norvegicus 66-87 1970426-0 1990 Inhibition of hippocampal CA1 neurons by 5-hydroxytryptamine, derived from the dorsal raphe nucleus and the 5-hydroxytryptamine1A agonist SM-3997. Serotonin 41-60 carbonic anhydrase 1 Rattus norvegicus 26-29 2404608-3 1990 These results show that chicken pancreatic islet A cells contain glucagon, serotonin, and aromatic L-amino acid decarboxylase, an enzyme involved in the synthesis of serotonin. Serotonin 166-175 dopa decarboxylase Gallus gallus 90-125 33762731-4 2021 Here we report five structures of 5-HT receptor-G-protein complexes: 5-HT1A in the apo state, bound to 5-HT or bound to the antipsychotic drug aripiprazole; 5-HT1D bound to 5-HT; and 5-HT1E in complex with a 5-HT1E- and 5-HT1F-selective agonist, BRL-54443. Serotonin 34-38 5-hydroxytryptamine receptor 1A Homo sapiens 69-75 33774619-5 2021 We hypothesized that perturbed brain GLUT1/GLUT3 regulated 5-HT-SERT imbalance, which serves as a contributing factor to postnatal neuropsychiatric phenotypes, with OXT/OXTR providing a counterbalance. Serotonin 59-63 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 37-42 33774619-5 2021 We hypothesized that perturbed brain GLUT1/GLUT3 regulated 5-HT-SERT imbalance, which serves as a contributing factor to postnatal neuropsychiatric phenotypes, with OXT/OXTR providing a counterbalance. Serotonin 59-63 solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus 43-48 33774619-5 2021 We hypothesized that perturbed brain GLUT1/GLUT3 regulated 5-HT-SERT imbalance, which serves as a contributing factor to postnatal neuropsychiatric phenotypes, with OXT/OXTR providing a counterbalance. Serotonin 59-63 oxytocin receptor Mus musculus 169-173 33774619-10 2021 We conclude that in the IUGR during fetal brain development, reduced GLUT3 is associated with an imbalanced 5-HT-SERT axis. Serotonin 108-112 solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus 69-74 32502508-0 2020 PNU282987 alleviates Abeta-induced anxiety and depressive-like behaviors through upregulation of alpha7nAChR by ERK-serotonin receptors pathway. Serotonin 116-125 amyloid beta (A4) precursor protein Mus musculus 21-26 32502508-0 2020 PNU282987 alleviates Abeta-induced anxiety and depressive-like behaviors through upregulation of alpha7nAChR by ERK-serotonin receptors pathway. Serotonin 116-125 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 97-108 32502508-10 2020 Our study provides a new insight into the mechanism of alpha7nAChR in Abeta-induced depression and anxiety-related symptoms through the regulation of ERK1/2 pathway and the potential association with serotonin receptors. Serotonin 200-209 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 55-66 32502508-10 2020 Our study provides a new insight into the mechanism of alpha7nAChR in Abeta-induced depression and anxiety-related symptoms through the regulation of ERK1/2 pathway and the potential association with serotonin receptors. Serotonin 200-209 amyloid beta (A4) precursor protein Mus musculus 70-75 34871865-10 2022 The obtained result demonstrates that the ZrO2-CuO-CeO2/Gr/CPE has good selectivity, stability, reproducibility, and repeatability, and can be used for the routine analysis of Dop, Ser and Trp. Serotonin 181-184 carboxypeptidase E Homo sapiens 59-62 34838579-0 2022 Role of the cAMP-PKA-CREB-BDNF pathway in abnormal behaviours of serotonin transporter knockout mice. Serotonin 65-74 brain derived neurotrophic factor Mus musculus 26-30 34801691-8 2022 CONCLUSION: Lifetime supply of n-3 PUFA ameliorated bone loss induced by chronic stress by regulating hypothalamic-pituitary-adrenal axis activity and serotonin-CREB signaling. Serotonin 151-160 cAMP responsive element binding protein 1 Rattus norvegicus 161-165 34535545-10 2021 Among the strongest correlates of global editing rates were snoRNAs from the SNORD115 and SNORD116 cluster (15q11), known to modulate serotonin receptor processing and to colocalize with ADAR2. Serotonin 134-143 small nucleolar RNA, C/D box 115 cluster Homo sapiens 77-85 34535545-10 2021 Among the strongest correlates of global editing rates were snoRNAs from the SNORD115 and SNORD116 cluster (15q11), known to modulate serotonin receptor processing and to colocalize with ADAR2. Serotonin 134-143 Prader-Willi syndrome chromosome region 1 Homo sapiens 90-98 34816281-8 2022 In addition, progesterone (P4) secretion and cell viability were promoted in luteal cells treated with serotonin, and the stimulatory effects were blocked by luzindole (a non-selective MT1 and MT2 antagonist). Serotonin 103-112 metallothionein 1I, pseudogene Homo sapiens 185-188 34816281-8 2022 In addition, progesterone (P4) secretion and cell viability were promoted in luteal cells treated with serotonin, and the stimulatory effects were blocked by luzindole (a non-selective MT1 and MT2 antagonist). Serotonin 103-112 metallothionein 2A Homo sapiens 193-196 34816281-9 2022 Finally, the expressions of MT1 and MT2 were augmented by serotonin in luteal cells. Serotonin 58-67 metallothionein 1I, pseudogene Homo sapiens 28-31 34816281-9 2022 Finally, the expressions of MT1 and MT2 were augmented by serotonin in luteal cells. Serotonin 58-67 metallothionein 2A Homo sapiens 36-39 34795483-1 2021 Background: Monoamine oxidase-A (MAO-A) decomposes dopamine and serotonin, and decreased MAO-A expression increases monoamine levels and is related to the pathophysiology of schizophrenia. Serotonin 64-73 monoamine oxidase A Homo sapiens 12-31 34795483-1 2021 Background: Monoamine oxidase-A (MAO-A) decomposes dopamine and serotonin, and decreased MAO-A expression increases monoamine levels and is related to the pathophysiology of schizophrenia. Serotonin 64-73 monoamine oxidase A Homo sapiens 33-38 34560070-9 2021 More importantly, by western blotting, we detected that the upregulation of Tph1, AADC and MAO-A expression induced by cisplatin both in vivo and in vitro could be obviously suppressed by SH to decrease 5-HT synthesis and mitochondrial 5-HT degradation. Serotonin 203-207 monoamine oxidase A Homo sapiens 91-96 34560070-9 2021 More importantly, by western blotting, we detected that the upregulation of Tph1, AADC and MAO-A expression induced by cisplatin both in vivo and in vitro could be obviously suppressed by SH to decrease 5-HT synthesis and mitochondrial 5-HT degradation. Serotonin 236-240 monoamine oxidase A Homo sapiens 91-96 34832862-2 2021 Histamine H3 receptor antagonists may represent an effective therapy as they have been shown to modulate histamine synthesis and release and affect a number of other neurotransmitters (norepinephrine, acetylcholine, gamma-aminobutyric acid, serotonin, substance P) thus influencing the food intake. Serotonin 241-250 histamine receptor H3 Rattus norvegicus 0-21 34280394-7 2021 5-HT2A receptors, 5-HT synthetase and MAO-A were expressed in hepatocytes; their gene and protein expression were upregulated by CCl4, which led to the degradation of mitochondrial 5-HT and overproduction of reactive oxygen species (ROS). Serotonin 181-185 monoamine oxidase A Homo sapiens 38-43 34493397-1 2021 INTRODUCTION: Serotonin is highly implicated in the regulation of emotional state and the execution of cognitive tasks, so much so that the serotonin transporter genes (5-HTT, SLC6A4) and the serotonin receptor genes (HTR1A, HTR1B, HTR2A) have become the perfect candidates when studying the effects that these genes and their polymorphic variations have on depression characteristics. Serotonin 14-23 5-hydroxytryptamine receptor 1A Homo sapiens 218-223 34285037-9 2021 Addressing the positive feedback loop between 5-HT and NLRP3 signaling could provide potential therapeutic targets for CRC. Serotonin 46-50 NLR family, pyrin domain containing 3 Mus musculus 55-60 34396611-3 2021 Moreover, the activation of PPARalpha by the administration of OEA or PEA increases the extracellular contents of neurotransmitters linked to the control of wakefulness; however, the role of PPARalpha activated by OEA or PEA on additional biochemicals related to waking regulation, such as acetylcholine (ACh) and 5-hydroxytryptamine (5-HT), has not been fully studied. Serotonin 314-333 peroxisome proliferator activated receptor alpha Homo sapiens 28-37 34396611-3 2021 Moreover, the activation of PPARalpha by the administration of OEA or PEA increases the extracellular contents of neurotransmitters linked to the control of wakefulness; however, the role of PPARalpha activated by OEA or PEA on additional biochemicals related to waking regulation, such as acetylcholine (ACh) and 5-hydroxytryptamine (5-HT), has not been fully studied. Serotonin 314-333 peroxisome proliferator activated receptor alpha Homo sapiens 191-200 34396611-3 2021 Moreover, the activation of PPARalpha by the administration of OEA or PEA increases the extracellular contents of neurotransmitters linked to the control of wakefulness; however, the role of PPARalpha activated by OEA or PEA on additional biochemicals related to waking regulation, such as acetylcholine (ACh) and 5-hydroxytryptamine (5-HT), has not been fully studied. Serotonin 335-339 peroxisome proliferator activated receptor alpha Homo sapiens 28-37 34396611-3 2021 Moreover, the activation of PPARalpha by the administration of OEA or PEA increases the extracellular contents of neurotransmitters linked to the control of wakefulness; however, the role of PPARalpha activated by OEA or PEA on additional biochemicals related to waking regulation, such as acetylcholine (ACh) and 5-hydroxytryptamine (5-HT), has not been fully studied. Serotonin 335-339 peroxisome proliferator activated receptor alpha Homo sapiens 191-200 34396611-10 2021 Our data suggest that the activation of PPARalpha by OEA or PEA produces significant changes on ACh and 5-HT levels measured from the basal forebrain and support the conclusion that PPARalpha is a suitable molecular element involved in the regulation of wake-related neurotransmitters. Serotonin 104-108 peroxisome proliferator activated receptor alpha Homo sapiens 40-49 34396611-10 2021 Our data suggest that the activation of PPARalpha by OEA or PEA produces significant changes on ACh and 5-HT levels measured from the basal forebrain and support the conclusion that PPARalpha is a suitable molecular element involved in the regulation of wake-related neurotransmitters. Serotonin 104-108 peroxisome proliferator activated receptor alpha Homo sapiens 182-191 34489696-5 2021 Microdialysis analysis revealed that the basal level of extracellular dopamine (DA) was significantly elevated, while the basal serotonin (5-HT) level tended to be reduced in the striatum of FFAR1 knockout (-/-) mice. Serotonin 128-137 free fatty acid receptor 1 Mus musculus 191-196 34489696-5 2021 Microdialysis analysis revealed that the basal level of extracellular dopamine (DA) was significantly elevated, while the basal serotonin (5-HT) level tended to be reduced in the striatum of FFAR1 knockout (-/-) mice. Serotonin 139-143 free fatty acid receptor 1 Mus musculus 191-196 34489696-6 2021 Interestingly, local application of a FFAR1 agonist, GW9508, markedly augmented the striatal 5-HT release in FFAR1 wild-type (+/+) mice, whereas topical application of a FFAR1 antagonist, GW1100, significantly reduced the 5-HT release. Serotonin 93-97 free fatty acid receptor 1 Mus musculus 38-43 34489696-6 2021 Interestingly, local application of a FFAR1 agonist, GW9508, markedly augmented the striatal 5-HT release in FFAR1 wild-type (+/+) mice, whereas topical application of a FFAR1 antagonist, GW1100, significantly reduced the 5-HT release. Serotonin 93-97 free fatty acid receptor 1 Mus musculus 109-114 34489696-6 2021 Interestingly, local application of a FFAR1 agonist, GW9508, markedly augmented the striatal 5-HT release in FFAR1 wild-type (+/+) mice, whereas topical application of a FFAR1 antagonist, GW1100, significantly reduced the 5-HT release. Serotonin 222-226 free fatty acid receptor 1 Mus musculus 170-175 34489696-10 2021 These results suggest that FFAR1 has a facilitatory role in striatal 5-HT release, and the evoked 5-HT release might contribute to enhance cocaine-induced locomotor activity. Serotonin 69-73 free fatty acid receptor 1 Mus musculus 27-32 34489696-10 2021 These results suggest that FFAR1 has a facilitatory role in striatal 5-HT release, and the evoked 5-HT release might contribute to enhance cocaine-induced locomotor activity. Serotonin 98-102 free fatty acid receptor 1 Mus musculus 27-32 34914250-3 2021 The pathogenesis of LPE has not been clarified, but it is believed to be related to the regulation of 5-HT and the 5-HT1a and 5-HT2c receptors from the perspective of the theory of 5-HT system neurotransmitter disorder. Serotonin 181-185 5-hydroxytryptamine receptor 1A Homo sapiens 115-121 34335254-6 2021 Moreover, duodenal I sc response to the serosal applications of both PGE2 and 5-HT was significantly attenuated in transient receptor potential vanilloid 4 (TRPV4) knockout mice. Serotonin 78-82 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 115-155 34335254-6 2021 Moreover, duodenal I sc response to the serosal applications of both PGE2 and 5-HT was significantly attenuated in transient receptor potential vanilloid 4 (TRPV4) knockout mice. Serotonin 78-82 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 157-162 34276291-3 2021 A recent study from our group used the tryptophan hydroxylase 2 (R439H) knock-in mouse line to evaluate the impact of genetic brain serotonin (5-HT) deficiency on behavioral responses to high fat diet (HFD) in male mice. Serotonin 143-147 CD36 molecule Mus musculus 192-195 34353741-8 2021 Moreover, LIMK2-deficient ASMs display abolished stretching-induced suppression of 5-hydroxytryptamine (5-HT) but not acetylcholine-evoked force, which is due to the differential contraction mechanisms adopted by the agonists. Serotonin 104-108 LIM motif-containing protein kinase 2 Mus musculus 10-15 34353741-9 2021 We propose that LIMK2-mediated cofilin phosphorylation is required for membrane cytoskeleton reorganization that is necessary for ASM mechanical adaption including the 5-HT-evoked length-sensitive effect. Serotonin 168-172 LIM motif-containing protein kinase 2 Mus musculus 16-21 34207786-3 2021 In this study, we cloned and characterized the full-length cDNA of three serotonin receptor genes (HTR1B, HTR1E and HTR1F) in chicken pituitaries. Serotonin 73-82 5-hydroxytryptamine receptor 1F Gallus gallus 116-121 34851520-3 2021 SEP-363856 is a trace amine-associated receptor 1 (TAAR1) agonist and a serotonin 5-HT1a agonist with potential antipsychotic properties. Serotonin 72-81 5-hydroxytryptamine receptor 1A Homo sapiens 82-88 35547876-3 2022 It was found that acupoint stimulation attenuated CIPN and GI by modulating the 5-hydroxytryptamine system in dorsal root ganglia, the dorsal horn of the spinal cord, and the duodenum by reducing oxidative stress and neuroinflammation. Serotonin 80-99 G protein subunit alpha i1 Homo sapiens 59-61 35459266-4 2022 First, in vivo local-field potential recording revealed that auditory cortex in Grin1 mutant mice became hyper-excitable upon exposure to acoustic click-train stimuli that release 5-HT in the cortex. Serotonin 180-184 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 80-85 35438303-3 2022 To examine the potential mechanisms of 5-HT receptor genes in opioid use disorder, we first determined the associations between several single-nucleotide polymorphism (SNPs) in three representative 5-HT receptor genes (HTR1B, HTR2A, and HTR3B) and susceptibility to heroin use disorder in 1731 participants. Serotonin 39-43 5-hydroxytryptamine receptor 3B Homo sapiens 237-242 35462922-14 2022 The observed patterns of SERT, NET P-gp, BCRP and MRP3 expression and activity may be associated with transporter activity or decreased placental permeability in the 1st trimester to transporter specific substrates including commonly used psychoactive medications such as anti-depressants, anti-psychotics, and amphetamines, while transport of nutrients and serotonin is important in the 1st trimester. Serotonin 358-367 BCR pseudogene 1 Homo sapiens 41-45 35051489-3 2022 This study was to investigate the hypothesis that BBR treats depressive-like behavior by shifting the balance of the kynurenine (KYN)/serotonin (5-HT) pathway toward the 5-HT pathway through downregulated indoleamine 2,3-dioxygenase 1 (IDO1), monoamine oxidase A (MAOA) and upregulated dopamine decarboxylase (DDC) in hippocampus. Serotonin 134-143 indoleamine 2,3-dioxygenase 1 Mus musculus 205-234 35051489-3 2022 This study was to investigate the hypothesis that BBR treats depressive-like behavior by shifting the balance of the kynurenine (KYN)/serotonin (5-HT) pathway toward the 5-HT pathway through downregulated indoleamine 2,3-dioxygenase 1 (IDO1), monoamine oxidase A (MAOA) and upregulated dopamine decarboxylase (DDC) in hippocampus. Serotonin 145-149 indoleamine 2,3-dioxygenase 1 Mus musculus 205-234 35051489-3 2022 This study was to investigate the hypothesis that BBR treats depressive-like behavior by shifting the balance of the kynurenine (KYN)/serotonin (5-HT) pathway toward the 5-HT pathway through downregulated indoleamine 2,3-dioxygenase 1 (IDO1), monoamine oxidase A (MAOA) and upregulated dopamine decarboxylase (DDC) in hippocampus. Serotonin 170-174 indoleamine 2,3-dioxygenase 1 Mus musculus 205-234 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 148-152 C-C motif chemokine ligand 4 Homo sapiens 100-104 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 148-152 monoamine oxidase A Homo sapiens 194-213 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 148-152 monoamine oxidase A Homo sapiens 215-220 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 248-252 C-C motif chemokine ligand 4 Homo sapiens 100-104 35202708-1 2022 Previously we found that acute liver injury (ALI) with inflammation caused by carbon tetrachloride (CCl4) was associated with the activation of the 5-HT degradation system (5DS), which includes monoamine oxidase A (MAO-A), the 5-HT2A receptor, and 5-HT synthases in hepatocytes. Serotonin 248-252 monoamine oxidase A Homo sapiens 215-220 35235945-9 2022 It was further confirmed that 5-HT could increase intracellular calcium levels by increasing PTHrP and decreasing plasma-membrane Ca2+-ATPases1(PMCA1) in GMEC (P <0.05). Serotonin 30-34 parathyroid hormone-related protein Capra hircus 93-98 35210396-0 2022 Human alpha-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Serotonin 46-55 synuclein, alpha Mus musculus 6-21 35210396-7 2022 We showed that adeno-associated virus (AAV5)-induced overexpression of wild-type human alpha-Syn (h-alpha-Syn) in raphe 5-HT neurons triggers progressive accumulation, phosphorylation, and aggregation of h-alpha-Syn protein in the 5-HT system. Serotonin 120-124 synuclein alpha Homo sapiens 87-96 35210396-7 2022 We showed that adeno-associated virus (AAV5)-induced overexpression of wild-type human alpha-Syn (h-alpha-Syn) in raphe 5-HT neurons triggers progressive accumulation, phosphorylation, and aggregation of h-alpha-Syn protein in the 5-HT system. Serotonin 231-235 synuclein alpha Homo sapiens 87-96 35210396-11 2022 Early preservation of 5-HT function by reducing alpha-Syn synthesis/accumulation may alleviate PD-related depressive symptoms. Serotonin 22-26 synuclein, alpha Mus musculus 48-57 35155042-0 2022 Gut Microbiota Regulates the Sympathetic Nerve Activity and Peripheral Serotonin Through Hypothalamic MicroRNA-204 in Order to Increase the Browning of White Adipose Tissue in Obesity. Serotonin 71-80 microRNA 204 Homo sapiens 102-114 34347076-9 2022 Upregulation of 5-HTR1B gene and increased association of FOXO1 with ATF4 complex were identified as associated mechanisms concomitant to overt inflammation and high levels of gut-derived serotonin in 14-week and 24-week Winnie mice. Serotonin 188-197 forkhead box O1 Mus musculus 58-63 35163521-2 2022 Disruption of central 5-HT signaling via 5-HT2C receptors (5-HT2CRs) induces leptin-independent hyperphagia in mice, leading to late-onset obesity, insulin resistance, and impaired glucose tolerance. Serotonin 22-26 leptin Mus musculus 77-83 2620071-11 1989 PAF activity was assessed by rabbit platelet aggregation and serotonin-release bioassays after lipid extraction and separation by thin-layer chromatography. Serotonin 61-70 PCNA clamp associated factor Homo sapiens 0-3 2477512-0 1989 Modulation of ionic currents in Aplysia motor neuron B15 by serotonin, neuropeptides, and second messengers. Serotonin 60-69 NADH:ubiquinone oxidoreductase subunit B4 Homo sapiens 53-56 2804200-5 1989 The PAF was measured (in fmole equivalents of synthetic PAF) by a bioassay based on the capacity of aliquots of the extracts to release [3H]-serotonin from platelets isolated from whole blood of rabbits and prelabeled with [3H]-serotonin. Serotonin 141-150 PCNA clamp associated factor Homo sapiens 4-7 2804200-5 1989 The PAF was measured (in fmole equivalents of synthetic PAF) by a bioassay based on the capacity of aliquots of the extracts to release [3H]-serotonin from platelets isolated from whole blood of rabbits and prelabeled with [3H]-serotonin. Serotonin 228-237 PCNA clamp associated factor Homo sapiens 4-7 2539375-3 1989 Stimulation of these cells with serotonin, histamine, carbachol, or the Ca2+ ionophore, ionomycin, increases free cytosolic Ca2+ concentrations and the extent of myosin light chain phosphorylation. Serotonin 32-41 myosin heavy chain 14 Homo sapiens 162-168 2473630-1 1989 Histamine releasing factor (HRF) generated in vitro by spleen cells of immunized mice activates homologous peritoneal mast cells (both normal and sensitized) for small but consistent, dose-dependent histamine and 5-hydroxytryptamine release. Serotonin 213-232 endothelial PAS domain protein 1 Mus musculus 0-26 2473630-1 1989 Histamine releasing factor (HRF) generated in vitro by spleen cells of immunized mice activates homologous peritoneal mast cells (both normal and sensitized) for small but consistent, dose-dependent histamine and 5-hydroxytryptamine release. Serotonin 213-232 endothelial PAS domain protein 1 Mus musculus 28-31 2523233-1 1989 Serotonin lesioning studies were performed to determine the synaptic localization of the 5-HT1D receptor. Serotonin 0-9 5-hydroxytryptamine receptor 1D Rattus norvegicus 89-95 2603793-7 1989 The B2-receptor antagonists, D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg-TFA and D-Pro-Phe-Arg-heptylamide produced significant antagonism of the bradykinin-induced pain responses at doses which had no effect against 5-hydroxytryptamine or potassium chloride. Serotonin 217-236 bradykinin receptor B2 Homo sapiens 4-15 2545989-1 1989 We investigated the activity of bombesin (BN), neuromedin-C (NM-C) and neuromedin-B (NM-B) on serotonin (5-HT) release and reuptake in rat hypothalamus (HYP) in vitro. Serotonin 94-103 neuromedin B Rattus norvegicus 71-83 2545989-1 1989 We investigated the activity of bombesin (BN), neuromedin-C (NM-C) and neuromedin-B (NM-B) on serotonin (5-HT) release and reuptake in rat hypothalamus (HYP) in vitro. Serotonin 94-103 neuromedin B Rattus norvegicus 85-89 2515672-1 1989 Changes in viscous drag acting upon the endothelial lining and a number of circulating agonists (ATP, ADP, serotonin, thrombin) stimulate the release of EDRF from intact endothelial cells. Serotonin 107-116 alpha hemoglobin stabilizing protein Homo sapiens 153-157 3138543-6 1988 We now report that the protein product of the genomic clone, G21, transiently expressed in monkey kidney cells has all the typical ligand-binding characteristics of the 5-hydroxytryptamine (5-HT1A) receptor. Serotonin 169-188 5-hydroxytryptamine receptor 1A Homo sapiens 190-206 3045568-0 1988 Serotonin stimulates DNA synthesis in fibroblasts acting through 5-HT1B receptors coupled to a Gi-protein. Serotonin 0-9 5-hydroxytryptamine receptor 1B Cricetulus griseus 65-71 3045568-9 1988 We show that the mitogenicity of 5-hydroxytryptamine can be uncoupled from phospholipase C activation that is mediated by 5-HT2 receptors, but correlates perfectly with inhibition of adenylate cyclase through 5-HT1B receptor. Serotonin 33-52 5-hydroxytryptamine receptor 1B Cricetulus griseus 209-215 2901680-1 1988 In low cerveau isole transected rats, the effects of microiontophoretic application of putative serotonin 5-HT1A and 5-HT1B agonists on the spontaneous firing rate of CA1 pyramidal cells were compared to those of 5-HT. Serotonin 96-105 carbonic anhydrase 1 Rattus norvegicus 167-170 2465543-10 1988 Thus, some, but not all putative substance P antagonists may also be behavioral antagonists of serotonin in the mouse spinal cord. Serotonin 95-104 tachykinin 1 Mus musculus 33-44 3390981-0 1988 Iodine-123 MIBG imaging in a generalized pancreatic polypeptide-gastrin-serotonin secreting tumor. Serotonin 72-81 gastrin Homo sapiens 64-71 2966310-1 1988 In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified. Serotonin 43-52 5-hydroxytryptamine receptor 1A Homo sapiens 71-77 3362407-0 1988 Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe. Serotonin 38-47 prolactin Ovis aries 13-22 2454837-8 1988 Outgrowth of 5HT-immunoreactive fibres was extensive, and displayed the typical pattern of 5HT innervation in the normal hippocampus-the densest plexuses were found in the dentate gyrus, with sparser networks in the CA1 and CA2 regions. Serotonin 13-16 carbonic anhydrase 1 Rattus norvegicus 216-219 3166432-12 1988 At 5 U/ml (approximately 8.6 x 10(-8) M) antithrombin III markedly inhibited contractions of basilar arteries to prostaglandin E2 but had no effect of contractions elicited by 10(-6) M serotonin in the umbilical artery, nor did aprotinin (5 x 10(-4) M). Serotonin 185-194 serpin family C member 1 Homo sapiens 41-57 3441315-0 1987 Secretion of prolactin in response to serotonin requires an intact hypothalamo-pituitary axis in the ewe. Serotonin 38-47 prolactin Ovis aries 13-22 2891550-1 1987 Using radioligand binding techniques and human frontal cortex, we determined the equilibrium dissociation constants (KDs) of 17 neuroleptics at the serotonin 5-HT1A and serotonin 5-HT2 receptors with [3H]WB4101 and [3H]ketanserin, respectively. Serotonin 148-157 5-hydroxytryptamine receptor 1A Homo sapiens 158-164 3312904-1 1987 The effect of serotonin (5-HT) on the basal and gonadotrophin-releasing hormone (GnRH)-stimulated release of luteinizing hormone (LH) was studied in rat adenohypophysis in vitro. Serotonin 14-23 gonadotropin releasing hormone 1 Rattus norvegicus 81-85 3312904-3 1987 Serotonin added to the culture medium slightly dimished the basal release of LH and markedly inhibited the release of LH induced by GnRH. Serotonin 0-9 gonadotropin releasing hormone 1 Rattus norvegicus 132-136 2958301-4 1987 Two 5-HT1A ligands, LY165163 and 8-OH-DPAT, mimicked the effect of serotonin, although with slower kinetics. Serotonin 67-76 5-hydroxytryptamine receptor 1A Homo sapiens 4-10 2953624-2 1987 ANF caused a concentration-dependent relaxation in arterial strips submaximally precontracted with noradrenaline, 5-hydroxytryptamine, or high-potassium solution (10-30 mM). Serotonin 114-133 natriuretic peptide A Canis lupus familiaris 0-3 2952898-0 1987 Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Serotonin 24-33 5-hydroxytryptamine receptor 1A Homo sapiens 35-41 2435178-1 1987 To determine if the enhanced cortisol response to oral administration of the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) that has been reported in unmedicated depressed and manic patients might be related to brain monoaminergic metabolism, the authors assessed correlations between 5-HTP-induced cortisol response and CSF in nine depressed patients. Serotonin 77-86 colony stimulating factor 2 Homo sapiens 329-332 2435178-1 1987 To determine if the enhanced cortisol response to oral administration of the serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) that has been reported in unmedicated depressed and manic patients might be related to brain monoaminergic metabolism, the authors assessed correlations between 5-HTP-induced cortisol response and CSF in nine depressed patients. Serotonin 88-92 colony stimulating factor 2 Homo sapiens 329-332 2436719-1 1987 Serotonin binding protein (SBP) is a neuron-specific protein that binds serotonin (5-HT) with high affinity and is concentrated in synaptic vesicles. Serotonin 72-81 spermine binding protein Rattus norvegicus 0-25 2436719-1 1987 Serotonin binding protein (SBP) is a neuron-specific protein that binds serotonin (5-HT) with high affinity and is concentrated in synaptic vesicles. Serotonin 72-81 spermine binding protein Rattus norvegicus 27-30 2433298-1 1987 Isolated human basilar arteries were used in this study to evaluate the inhibitory effect of antithrombin III (AT III), thrombin, and alpha 2-macroglobulin (alpha 2-M) on contractions elicited by K+, serotonin (5-HT), prostaglandin (PG) D2, PGF2 alpha, and plasmin. Serotonin 200-209 serpin family C member 1 Homo sapiens 93-109 2433298-1 1987 Isolated human basilar arteries were used in this study to evaluate the inhibitory effect of antithrombin III (AT III), thrombin, and alpha 2-macroglobulin (alpha 2-M) on contractions elicited by K+, serotonin (5-HT), prostaglandin (PG) D2, PGF2 alpha, and plasmin. Serotonin 200-209 alpha-2-macroglobulin Homo sapiens 134-155 3815073-1 1987 High-affinity [3H]serotonin (5-hydroxytryptamine, 5-HT) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-HT1A, 5-HT1B and 5-HT3) based on affinity for [3H]serotonin and spiperone. Serotonin 18-27 5-hydroxytryptamine receptor 1A Homo sapiens 153-159 3815073-1 1987 High-affinity [3H]serotonin (5-hydroxytryptamine, 5-HT) binding sites from human frontal cortex can be divided into at least 3 pharmacological subtypes (5-HT1A, 5-HT1B and 5-HT3) based on affinity for [3H]serotonin and spiperone. Serotonin 29-48 5-hydroxytryptamine receptor 1A Homo sapiens 153-159 3541718-2 1987 The amount of cell-associated PAF was estimated by measuring serotonin release from rabbit platelets. Serotonin 61-70 PCNA clamp associated factor Homo sapiens 30-33 2455195-4 1987 Examples include the interactions of neuropeptide Y (NPY) with noradrenaline (NA) and adenosine 5"-triphosphate (ATP) released from some sympathetic nerves; vasoactive intestinal polypeptide (VIP) with acetylcholine (ACh) released from some parasympathetic nerves; and NPY and 5-hydroxytryptamine (5-HT) released from intracardiac neurones supplying coronary vessels. Serotonin 277-296 neuropeptide Y Homo sapiens 37-51 2455195-4 1987 Examples include the interactions of neuropeptide Y (NPY) with noradrenaline (NA) and adenosine 5"-triphosphate (ATP) released from some sympathetic nerves; vasoactive intestinal polypeptide (VIP) with acetylcholine (ACh) released from some parasympathetic nerves; and NPY and 5-hydroxytryptamine (5-HT) released from intracardiac neurones supplying coronary vessels. Serotonin 277-296 neuropeptide Y Homo sapiens 53-56 3566833-1 1986 In psychopharmacological tests in rats and mice, 4-(5-chloro-benzofuranyl-2)-1-methylpiperidine HC1 (CGP 4718 A) was found to exert behavioral effects typical of both monoamine oxidase (MAO)-A and 5-hydroxytryptamine (5-HT) uptake inhibitors (reserpine antagonism, L-5-HTP potentiation, antiaggressive activity in isolated mice). Serotonin 197-216 heterochromatin, Chr 1 Mus musculus 96-99 3566833-1 1986 In psychopharmacological tests in rats and mice, 4-(5-chloro-benzofuranyl-2)-1-methylpiperidine HC1 (CGP 4718 A) was found to exert behavioral effects typical of both monoamine oxidase (MAO)-A and 5-hydroxytryptamine (5-HT) uptake inhibitors (reserpine antagonism, L-5-HTP potentiation, antiaggressive activity in isolated mice). Serotonin 218-222 heterochromatin, Chr 1 Mus musculus 96-99 3098890-0 1986 Serotonin induces gonadotrophin release through stimulation of LH-releasing hormone release from the median eminence. Serotonin 0-9 gonadotropin releasing hormone 1 Rattus norvegicus 63-83 3778827-4 1986 Anti-PlA1 at high concentration did not cause [14C]serotonin release and inhibited serotonin release by other alloantibodies to antigens on the platelet surface. Serotonin 83-92 POU class 2 homeobox 3 Homo sapiens 5-9 3022186-4 1986 Moreover, the antinociceptive effect induced by 5-hydroxytryptamine administered into nucleus accumbens could be blocked by naloxone injected into the same site, whereas the antinociception elicited by intra-accumbens injection of [D-Ala2,D-Leu5]enkephalin was not affected by cinanserin, a 5-hydroxytryptamine blocking agent. Serotonin 48-67 tripartite motif containing 13 Homo sapiens 241-245 3730591-4 1986 The difference was revealed between the influence of some drugs on deamination of two monoamine oxidase A substrates: norepinephrine and serotonin. Serotonin 137-146 monoamine oxidase A Bos taurus 86-105 3461852-1 1986 Serotonin and histamine H1, H2 receptor agonists or antagonists inhibited [3H]histamine uptake by HL-60 cells, according to the following order of potency: impromidine greater than 4-MH greater than histamine greater than AET greater than PEA and: cimetidine, histamine greater than diphenhydramine, serotonin. Serotonin 300-309 histamine receptor H1 Homo sapiens 14-39 2937776-6 1986 The consistent findings of an increased risk for suicide in patients with low CSF 5-HIAA underlines the importance of exploring drugs that act on serotonin transmission. Serotonin 146-155 colony stimulating factor 2 Homo sapiens 78-81 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 8-17 monoamine oxidase A Homo sapiens 71-76 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 8-17 monoamine oxidase A Homo sapiens 254-259 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 125-134 monoamine oxidase A Homo sapiens 71-76 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 125-134 monoamine oxidase A Homo sapiens 254-259 3941912-5 1986 Synthesis of melatonin from serotonin in the pineal gland requires the enzymes N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 28-37 solute carrier family 38, member 3 Mus musculus 79-98 3941912-5 1986 Synthesis of melatonin from serotonin in the pineal gland requires the enzymes N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 28-37 solute carrier family 38, member 3 Mus musculus 100-103 2434059-2 1986 There is a good correlation between DDT-induced tremor and an increase in the levels of the metabolites of norepinephrine (NE), serotonin (5HT) and, to a lesser extent, dopamine (DA) in the brain stem (BS), hypothalamus (HYP), striatum (STR), or hippocampus (HPC). Serotonin 128-137 D-dopachrome tautomerase Rattus norvegicus 36-39 2434059-2 1986 There is a good correlation between DDT-induced tremor and an increase in the levels of the metabolites of norepinephrine (NE), serotonin (5HT) and, to a lesser extent, dopamine (DA) in the brain stem (BS), hypothalamus (HYP), striatum (STR), or hippocampus (HPC). Serotonin 139-142 D-dopachrome tautomerase Rattus norvegicus 36-39 3875898-2 1985 The reagents recognized different populations of neurons: those that recognized MAO A were located in cell groups containing catecholamines, including the substantia nigra, nucleus locus coeruleus, nucleus subcoeruleus, and the periventricular region of the hypothalamus, whereas those that recognized MAO B were observed in serotonin regions, including the nucleus raphe dorsalis and nucleus centralis superior. Serotonin 325-334 monoamine oxidase A Homo sapiens 80-85 2413943-5 1985 The highest frequency was observed at 27-28 degrees C. Dopamine, 5-hydroxytryptamine, histamine, acetylcholine, glutamic acid, substance P, and thyrotropin releasing hormone accelerated the respiratory frequency when applied by perfusion to the brainstem, whereas noradrenaline, gamma-aminobutyric acid, glycine, and [Met5] enkephalin and [Leu5] enkephalin slowed the frequency. Serotonin 66-84 proenkephalin Rattus norvegicus 324-334 2413943-5 1985 The highest frequency was observed at 27-28 degrees C. Dopamine, 5-hydroxytryptamine, histamine, acetylcholine, glutamic acid, substance P, and thyrotropin releasing hormone accelerated the respiratory frequency when applied by perfusion to the brainstem, whereas noradrenaline, gamma-aminobutyric acid, glycine, and [Met5] enkephalin and [Leu5] enkephalin slowed the frequency. Serotonin 66-84 proenkephalin Rattus norvegicus 346-356 4024102-3 1985 In the rat, renal ODC responsiveness to growth hormone, angiotensin, vasopressin, isoproterenol, and serotonin was absent at birth and matured 3 to 4 weeks later. Serotonin 101-110 ornithine decarboxylase 1 Rattus norvegicus 18-21 34065903-4 2021 The SIBO-D patients showed an increased serum concentration of 5-HT and small intestinal mucosa mRNA expression of tryptophan hydroxylase 1 (TPH-1), a rate-limiting enzyme in 5-HT biosynthesis. Serotonin 175-179 tryptophan hydroxylase 1 Homo sapiens 115-139 34065903-4 2021 The SIBO-D patients showed an increased serum concentration of 5-HT and small intestinal mucosa mRNA expression of tryptophan hydroxylase 1 (TPH-1), a rate-limiting enzyme in 5-HT biosynthesis. Serotonin 175-179 tryptophan hydroxylase 1 Homo sapiens 141-146 35525464-6 2022 The tryptophan hydroxylase 1a (tph1a) and caspase-3 (casp3) genes were significantly upregulated in Cu25 + MPs group, indicating a potential dysregulation of serotonin synthesis and apoptosis pathways, respectively. Serotonin 158-167 caspase 3, apoptosis-related cysteine peptidase a Danio rerio 42-51 35525464-6 2022 The tryptophan hydroxylase 1a (tph1a) and caspase-3 (casp3) genes were significantly upregulated in Cu25 + MPs group, indicating a potential dysregulation of serotonin synthesis and apoptosis pathways, respectively. Serotonin 158-167 caspase 3, apoptosis-related cysteine peptidase a Danio rerio 53-58 35398393-0 2022 Estradiol reduced 5-HT reuptake by Downregulating the Gene Expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor beta and the MAPK/ERK signaling pathway. Serotonin 18-22 solute carrier family 29 member 4 Rattus norvegicus 118-125 35398393-0 2022 Estradiol reduced 5-HT reuptake by Downregulating the Gene Expression of Plasma Membrane Monoamine Transporter (PMAT, Slc29a4) through estrogen receptor beta and the MAPK/ERK signaling pathway. Serotonin 18-22 estrogen receptor 2 Rattus norvegicus 135-157 35398393-5 2022 Furthermore, estradiol inhibits PMAT expression and reduced 5-HT reuptake in neurons and astrocytes and estradiol regulated the PMAT expression mainly by affecting estrogen receptor beta (ERbeta) at the genomic level in astrocytes. Serotonin 60-64 estrogen receptor 2 Rattus norvegicus 164-186 35398393-5 2022 Furthermore, estradiol inhibits PMAT expression and reduced 5-HT reuptake in neurons and astrocytes and estradiol regulated the PMAT expression mainly by affecting estrogen receptor beta (ERbeta) at the genomic level in astrocytes. Serotonin 60-64 estrogen receptor 2 Rattus norvegicus 188-194 35398393-7 2022 In conclusion, estradiol inhibits 5-HT reuptake by regulating PMAT expression at the genomic level through ERbeta and the MAPK/ERK signaling pathway, highlighting the importance of PMAT in the antidepressant effects of estradiol through 5-HT clearance reduction. Serotonin 34-38 estrogen receptor 2 Rattus norvegicus 107-113 35635755-6 2022 Through various metabolites (SCFAs, secondary bile acid, and serotonin), the gut microbiota plays a significant role in regulating glucose homeostasis, oxidative stress, and T2D-associated pro-inflammatory cytokines (IL-1, IL-6). Serotonin 61-70 interleukin 1 alpha Homo sapiens 217-221 35452231-2 2022 In humans, serotonin sensing and signaling can occur by 12 G protein-coupled receptors (GPCRs) coupled to Galpha proteins. Serotonin 11-20 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 106-112 35452231-3 2022 In yeast, human serotonin GPCRs coupled to Galpha proteins have previously been shown to function as whole-cell biosensors of serotonin. Serotonin 16-25 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 43-49 35452231-3 2022 In yeast, human serotonin GPCRs coupled to Galpha proteins have previously been shown to function as whole-cell biosensors of serotonin. Serotonin 126-135 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 43-49 35628547-11 2022 Decrease of the vagally-induced bradycardia evoked by high doses of 5-HT and 5-CT was reproduced by L-694,247 (5-HT1D agonist) and blocked by prior administration of LY310762 (5-HT1D antagonist). Serotonin 68-72 5-hydroxytryptamine receptor 1D Rattus norvegicus 111-117 35628547-11 2022 Decrease of the vagally-induced bradycardia evoked by high doses of 5-HT and 5-CT was reproduced by L-694,247 (5-HT1D agonist) and blocked by prior administration of LY310762 (5-HT1D antagonist). Serotonin 68-72 5-hydroxytryptamine receptor 1D Rattus norvegicus 176-182 35600957-0 2022 The 5-HT and PLC Signaling Pathways Regulate the Secretion of IL-1beta, TNF-alpha and BDNF from NG2 Cells. Serotonin 4-8 chondroitin sulfate proteoglycan 4 Rattus norvegicus 96-99 35600957-1 2022 The present study was clarified the relationship between NG2 glial cells and 5-hydroxytryptamine (5-HT) to further revealed a role in the regulation of cortical excitability. Serotonin 98-102 chondroitin sulfate proteoglycan 4 Rattus norvegicus 57-60 35600957-3 2022 Different concentrations of 5-HT were applied to cultured NG2 cells. Serotonin 28-32 chondroitin sulfate proteoglycan 4 Rattus norvegicus 58-61 35545425-6 2022 5HT effect on TRH mRNA was not affected by PKA inhibition, but it diminished in the presence of PKCi suggesting involvement of PKC in 5HT-induced TRH increased transcription. Serotonin 0-3 histidine triad nucleotide binding protein 1, pseudogene 1 Rattus norvegicus 96-100 35614949-9 2022 Moreover, the system pharmacology assays were used to assess the physiological targets involved in the action of CKF, with results suggesting that CKF putatively functioned through the 5-HT-PKA-CREB-BDNF pathway. Serotonin 185-189 cAMP responsive element binding protein 1 Rattus norvegicus 194-198 35391733-10 2022 HSV infection induced expression of the critical serotonin synthesis enzymes TPH-1, TPH-2, and DOPA decarboxylase (DDC), as well as the serotonin transporter, SERT. Serotonin 49-58 tryptophan hydroxylase 1 Homo sapiens 77-82 2862967-6 1985 The putative role of corticotropin releasing factor as the mediator of norepinephrine and serotonin effects on feeding is discussed. Serotonin 90-99 corticotropin releasing hormone Homo sapiens 21-51 3923145-3 1985 The inhibitory effect of aspirin could be overcome by using 10 times higher PAF concentrations or, even more effectively, by combining threshold concentrations of both PAF and one of the other agonists studied (ADP, epinephrine, and U-46619, a stable endoperoxide analog, but not serotonin). Serotonin 280-289 PCNA clamp associated factor Homo sapiens 168-171 7768274-2 1995 ), a serotonin (5-hydroxytryptamine, 5-HT) releaser and re-uptake inhibitor, reduced the eating caused by neuropeptide Y (235 pmol) injected into the paraventricular nucleus of the hypothalamus. Serotonin 16-35 neuropeptide Y Homo sapiens 106-120 2984256-6 1985 The ability to inhibit release of [3H]serotonin from washed human platelets was at least 10 times less using human thrombomodulin compared with rabbit thrombomodulin. Serotonin 38-47 thrombomodulin Homo sapiens 115-129 35209087-2 2022 Here we describe the synthesis and biological evaluation of ten new arylpiperazine derivatives designed to obtain an affinity profile at serotonin 5-HT1A, 5-HT2A, 5-HT7 receptor, and dopamine D2 receptor of prospective drugs to treat the core symptoms of autism spectrum disorder (ASD) or psychosis. Serotonin 137-146 5-hydroxytryptamine receptor 1A Homo sapiens 147-153 7740514-0 1995 Serotonin is involved in the pathogenesis of hypertension developing during erythropoietin treatment in uremic rats. Serotonin 0-9 erythropoietin Rattus norvegicus 76-90 4006034-1 1985 Unsaturated platelet-activating factor (PAF) aggregates thrombocytes of healthy female volunteers and releases within 1 min up to 30.95% of the platelet serotonin. Serotonin 153-162 PCNA clamp associated factor Homo sapiens 12-38 4006034-1 1985 Unsaturated platelet-activating factor (PAF) aggregates thrombocytes of healthy female volunteers and releases within 1 min up to 30.95% of the platelet serotonin. Serotonin 153-162 PCNA clamp associated factor Homo sapiens 40-43 4006034-2 1985 Indomethacin does not inhibit the aggregation but reduces the release of serotonin induced by unsaturated PAF in citrated platelet-rich plasma (PRP). Serotonin 73-82 PCNA clamp associated factor Homo sapiens 106-109 34983399-14 2022 The MA-induced increase in c-fos expression in different PFC regions may be due to MA-evoked increases in synaptic concentrations of 5-HT, NE and/or DA. Serotonin 133-137 FBJ osteosarcoma oncogene Mus musculus 27-32 8788067-1 1995 GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively. Serotonin 286-295 GTP cyclohydrolase 1 Mus musculus 0-20 4044301-5 1985 In adjacent sections PNMT immunoreactivity was also seen in the serotonin-containing vesicles. Serotonin 64-73 phenylethanolamine-N-methyltransferase Rattus norvegicus 21-25 4044301-6 1985 However, its intravesicular distribution was different from that of serotonin; PNMT occupied the eccentric zone of the vesicles between the serotonin immunoreactive sites. Serotonin 140-149 phenylethanolamine-N-methyltransferase Rattus norvegicus 79-83 4044301-9 1985 The co-localization of serotonin and PNMT in the same vesicle is suggestive of a capacity for co-release of serotonin and epinephrine by the adrenal medulla. Serotonin 108-117 phenylethanolamine-N-methyltransferase Rattus norvegicus 37-41 8788067-1 1995 GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively. Serotonin 286-295 GTP cyclohydrolase 1 Mus musculus 22-25 8788067-4 1995 Using this antibody specific for GCH, we observed strong GCH immunostaining in the liver cells, in the dopamine-, noradrenaline-, adrenaline-, or serotonin-containing cells of the brain, and in the adrenal gland of mice. Serotonin 146-155 GTP cyclohydrolase 1 Mus musculus 33-36 7891891-5 1994 Previous reports have described the accumulation of the 5HT metabolite 5-hydroxyindoleacetic acid and increased activities of the 5HT-metabolizing enzyme MAOA in this same material from patients with hepatic encephalopathy. Serotonin 130-133 monoamine oxidase A Homo sapiens 154-158 2578061-1 1985 Significant amounts of acid-hydrolyzable conjugates of 3,4-dihydroxyphenylethylamine, norepinephrine, and 5-hydroxytryptamine were detected in lumbar CSF from 22 awake unpremedicated healthy individuals. Serotonin 106-125 colony stimulating factor 2 Homo sapiens 150-153 6736951-1 1984 Serotonin [5-hydroxytryptamine (5-HT)] enhances acetyl choline (ACh)-elicited contractures of Aplysia buccal muscles E1 and I5 . Serotonin 0-9 small nucleolar RNA, H/ACA box 73A Homo sapiens 117-126 6736951-1 1984 Serotonin [5-hydroxytryptamine (5-HT)] enhances acetyl choline (ACh)-elicited contractures of Aplysia buccal muscles E1 and I5 . Serotonin 11-30 small nucleolar RNA, H/ACA box 73A Homo sapiens 117-126 2558899-2 1989 The failure of specific antagonists of histamine, serotonin and substance P to affect this resistant contraction ruled out the participation of histamine, serotonin and/or substance P. Antiserum against neuropeptide Y (NPY) reduced this resistant contraction in a concentration-dependent manner and inhibited the action of 4-AP totally at a high concentration (1.25% dilution) whereas normal serum lacked this ability. Serotonin 50-59 neuropeptide Y Oryctolagus cuniculus 219-222 2558899-2 1989 The failure of specific antagonists of histamine, serotonin and substance P to affect this resistant contraction ruled out the participation of histamine, serotonin and/or substance P. Antiserum against neuropeptide Y (NPY) reduced this resistant contraction in a concentration-dependent manner and inhibited the action of 4-AP totally at a high concentration (1.25% dilution) whereas normal serum lacked this ability. Serotonin 155-164 neuropeptide Y Oryctolagus cuniculus 203-217 2558899-2 1989 The failure of specific antagonists of histamine, serotonin and substance P to affect this resistant contraction ruled out the participation of histamine, serotonin and/or substance P. Antiserum against neuropeptide Y (NPY) reduced this resistant contraction in a concentration-dependent manner and inhibited the action of 4-AP totally at a high concentration (1.25% dilution) whereas normal serum lacked this ability. Serotonin 155-164 neuropeptide Y Oryctolagus cuniculus 219-222 6736951-1 1984 Serotonin [5-hydroxytryptamine (5-HT)] enhances acetyl choline (ACh)-elicited contractures of Aplysia buccal muscles E1 and I5 . Serotonin 32-36 small nucleolar RNA, H/ACA box 73A Homo sapiens 117-126 7806692-1 1994 This is a report of a controlled trial of gepirone, a 5-hydroxytryptamine (5-HT1A) partial agonist azapirone related to buspirone, in the treatment of atypical depression. Serotonin 54-73 5-hydroxytryptamine receptor 1A Homo sapiens 75-81 2531014-1 1989 The responses of CA1 neurons to topical application of serotonin (5-HT) and selective 5-HT1a and 5-HT1b agonists were examined with intracellular recording in the hippocampal slice. Serotonin 55-64 carbonic anhydrase 1 Rattus norvegicus 17-20 7993956-1 1994 The present study had two objectives: (1) to provide information on neuroendocrine challenge tests that can lead to diagnostic tests in humans; and (2) to confirm our previous observation that chronic fluoxetine selectively inhibits serotonin (5-HT1A) receptor function. Serotonin 233-242 5-hydroxytryptamine receptor 1A Homo sapiens 244-260 6335051-4 1984 Injection of enkephalin at the background of serotonin lowering and raising in the brain favoured CRBA preservation. Serotonin 45-54 proenkephalin Rattus norvegicus 13-23 2791236-1 1989 We investigated the release of endothelium-derived relaxing factor (EDRF) in response to serotonin and histamine in the human internal mammary artery and saphenous vein. Serotonin 89-98 alpha hemoglobin stabilizing protein Homo sapiens 68-72 7976421-9 1994 The EDRF-inhibiting agent L-NMA caused a small contractile response at concentrations of 10(-6)-10(-5) M. ET as well as 5-HT added after pretreatment with L-NMA produced a larger contractile response than ET or 5-HT alone. Serotonin 120-124 alpha hemoglobin stabilizing protein Homo sapiens 4-8 2551205-1 1989 To assess metabolic functions of the pulmonary circulation during lung injury and subsequent recovery from injury, we measured angiotensin-converting enzyme (ACE) activity by means of benzoyl-phenylalanyl-alanyl-proline (BPAP) hydrolysis and 5-hydroxytryptamine (5-HT) removal in vivo in three groups of anesthetized rabbits. Serotonin 242-261 angiotensin-converting enzyme Oryctolagus cuniculus 158-161 2551205-1 1989 To assess metabolic functions of the pulmonary circulation during lung injury and subsequent recovery from injury, we measured angiotensin-converting enzyme (ACE) activity by means of benzoyl-phenylalanyl-alanyl-proline (BPAP) hydrolysis and 5-hydroxytryptamine (5-HT) removal in vivo in three groups of anesthetized rabbits. Serotonin 263-267 angiotensin-converting enzyme Oryctolagus cuniculus 127-156 2551205-1 1989 To assess metabolic functions of the pulmonary circulation during lung injury and subsequent recovery from injury, we measured angiotensin-converting enzyme (ACE) activity by means of benzoyl-phenylalanyl-alanyl-proline (BPAP) hydrolysis and 5-hydroxytryptamine (5-HT) removal in vivo in three groups of anesthetized rabbits. Serotonin 263-267 angiotensin-converting enzyme Oryctolagus cuniculus 158-161 6313646-2 1983 When bound to thrombomodulin, thrombin no longer induces platelets to either aggregate or release [14C] serotonin. Serotonin 104-113 thrombomodulin Homo sapiens 14-28 6193388-0 1983 Intrathecal serotonin in mice: analgesia and inhibition of a spinal action of substance P. Serotonin 12-21 tachykinin 1 Mus musculus 78-89 6193388-2 1983 Low doses (2.5-5 ng) of serotonin blocked the biting and scratching response elicited by intrathecal substance P. Serotonin 24-33 tachykinin 1 Mus musculus 101-112 8090792-4 1994 The effects of 5HT on burst duration (an increase) and on episode length (a decrease) are mimicked by the 5HT1a receptor agonists, 5-carboxamidotryptamine (5CT) and R(+)-8-OH-DPAT, and reversed by the 5HT1a receptor antagonist NAN-190. Serotonin 15-18 5-hydroxytryptamine receptor 1A Homo sapiens 106-120 7159481-0 1982 Monoamine oxidase type A: differences in selectivity towards l-norepinephrine compared to serotonin. Serotonin 90-99 monoamine oxidase A Homo sapiens 0-24 7159481-3 1982 Serotonin was a more selective substrate for MAO-A, being inhibited by low concentrations (less than 10(-7) M) of the irreversible MAO-A inhibitor, clorgyline, more consistently and to a greater extent (80-100%) than was l-norepinephrine (30-85%). Serotonin 0-9 monoamine oxidase A Homo sapiens 45-50 7159481-3 1982 Serotonin was a more selective substrate for MAO-A, being inhibited by low concentrations (less than 10(-7) M) of the irreversible MAO-A inhibitor, clorgyline, more consistently and to a greater extent (80-100%) than was l-norepinephrine (30-85%). Serotonin 0-9 monoamine oxidase A Homo sapiens 131-136 8090792-4 1994 The effects of 5HT on burst duration (an increase) and on episode length (a decrease) are mimicked by the 5HT1a receptor agonists, 5-carboxamidotryptamine (5CT) and R(+)-8-OH-DPAT, and reversed by the 5HT1a receptor antagonist NAN-190. Serotonin 15-18 5-hydroxytryptamine receptor 1A Homo sapiens 201-215 7159481-5 1982 Serotonin also had a 2- to 4-fold smaller apparent Km for MAO-A than l-norepinephrine and was deaminated 2- to 5-fold more readily by MAO in vitro in most tissues. Serotonin 0-9 monoamine oxidase A Homo sapiens 58-63 8021490-7 1994 The results show that inhibition of 5HT synthesis inhibits IL-2-stimulated human T cell proliferation and that addition of 5-hydroxytryptophan, a precursor of 5HT, reverses inhibition of T cell proliferation. Serotonin 36-39 interleukin 2 Mus musculus 59-63 2754715-0 1989 N-(phthalimidoalkyl) derivatives of serotonergic agents: a common interaction at 5-HT1A serotonin binding sites? Serotonin 88-97 5-hydroxytryptamine receptor 1A Homo sapiens 81-87 8000448-0 1994 Prolonged administration of imipramine and (+)-oxaprotiline, but not citalopram, results in sensitization of the rat hippocampal CA1 neurons to serotonin ex vivo. Serotonin 144-153 carbonic anhydrase 1 Rattus norvegicus 129-132 2551395-2 1989 The synergism in [Ca2+]i increase was also obtained in the presence of VP together with PAF, S with PAF as well as VP with S. Serotonin 93-94 PCNA clamp associated factor Homo sapiens 100-103 6896465-1 1982 Administration of delta-sleep-inducing peptide (DSIP) in vivo in a dose of 30 microgram/kg bw brings about MAO-A (substrate-serotonin) activation in synaptosome subfractions and cellular mitochondria from the brain structures (motor cortex, nucleus caudatus, thalamus). Serotonin 124-133 amine oxidase [flavin-containing] A Oryctolagus cuniculus 107-112 6278358-1 1982 D-Fenfluramine, an anorectic that releases serotonin (5-HT), repeatedly injected in rats (15 mg/kg per day) enhanced the met5-enkephalin and beta-endorphin content of the hyhpothalamus. Serotonin 54-58 proenkephalin Rattus norvegicus 126-136 2741308-0 1989 Acute and chronic effects of the trichothecene mycotoxin T-2 on rat brain regional concentrations of serotonin, tryptophan, and tyrosine. Serotonin 101-110 brachyury 2 Rattus norvegicus 57-60 8000448-1 1994 Prolonged (14 days, twice daily), but not acute, application of imipramine and (+)-oxaprotiline (10 mg/kg) induced sensitization of hippocampal CA1 neurons to the inhibitory effect of 5-hydroxytryptamine (5-HT), as studied ex vivo in the rat hippocampal slice preparation. Serotonin 184-203 carbonic anhydrase 1 Rattus norvegicus 144-147 2741308-4 1989 Chronic T-2 administration increased cerebellar tyrosine and serotonin concentrations, while cortical tryptophan concentrations were also increased. Serotonin 61-70 brachyury 2 Rattus norvegicus 8-11 8150086-2 1994 We here show that both nicotine and cytisine stimulate [3H]serotonin release in a dose-dependent manner; this effect is antagonized by alpha-bungarotoxin (alpha Bgtx) and alpha-conotoxin MI (alpha Ctx). Serotonin 59-68 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 197-200 2741308-5 1989 These results indicate that both acute and chronic administration of T-2 toxin cause differential changes in regional distribution levels of tyrosine, tryptophan, and serotonin. Serotonin 167-176 brachyury 2 Rattus norvegicus 69-72 6128148-2 1982 Impulse activity in an identified serotonin-containing neuron (GSN) produces a slow excitatory synaptic response in another identified neuron, the A neuron. Serotonin 34-43 gelsolin Homo sapiens 63-66 6128148-15 1982 Exogenously applied serotonin produces a similar voltage-dependent inward current response in the GSN as seen in the A neuron. Serotonin 20-29 gelsolin Homo sapiens 98-101 8075479-3 1994 Serotonin-IR was demonstrable in the carotid bodies of adult humans and it was coexpressed mostly with synaptophysin or PGP 9.5 in type I cells. Serotonin 0-9 ubiquitin C-terminal hydrolase L1 Homo sapiens 120-127 7130973-2 1982 Concentrations of 5-hydroxytryptamine and phenylethylamine, approximately at their Km values, were used as substrates for MAO A and B respectively. Serotonin 18-37 monoamine oxidase A Homo sapiens 122-127 2496202-5 1989 Similar to the endogenous enzymes, the expressed MAO A prefers serotonin as a substrate and is sensitive to the inhibitor clorgyline. Serotonin 63-72 monoamine oxidase A Homo sapiens 49-54 2748003-1 1989 Perfusion of the rat hippocampal slice in vitro by 5-hydroxytryptamine (5-HT) elicits 3 distinct actions recorded intracellularly from pyramidal cells in area CA1: a hyperpolarization, reduction in spike train elicited afterhyperpolarization (AHP) and depolarization. Serotonin 51-70 carbonic anhydrase 1 Rattus norvegicus 159-162 7327272-1 1981 One--day cold exposure decreases the monoamine oxidase type A activity by 52--54% (serotonin and noradrenaline substrates); the monoamine oxidase type B activity by 14%. Serotonin 83-92 monoamine oxidase A Homo sapiens 37-61 8019842-4 1994 In the present paper we show that human IL-1 and IL-6 are able to induce changes on protein phosphorylation in the leech central nervous system and that these changes are similar to those ones induced by the neurotransmitter serotonin. Serotonin 225-234 interleukin 1 alpha Homo sapiens 40-44 6175173-5 1981 All three serotonin antagonists showed a serotonin-like lowering effect on the activation of factor XII and on the level of prekallikrein in plasma (BOL 148 1.0-4.0 mg/kg; methysergide 0.10-0.60 mg/kg; ergotamine 0.10-0.60 mg/kg). Serotonin 10-19 coagulation factor XII Rattus norvegicus 93-103 2748003-1 1989 Perfusion of the rat hippocampal slice in vitro by 5-hydroxytryptamine (5-HT) elicits 3 distinct actions recorded intracellularly from pyramidal cells in area CA1: a hyperpolarization, reduction in spike train elicited afterhyperpolarization (AHP) and depolarization. Serotonin 72-76 carbonic anhydrase 1 Rattus norvegicus 159-162 2653571-0 1989 Serotonin stimulation of the period of in vitro LHRH release is estradiol dependent. Serotonin 0-9 gonadotropin releasing hormone 1 Rattus norvegicus 48-52 6175173-5 1981 All three serotonin antagonists showed a serotonin-like lowering effect on the activation of factor XII and on the level of prekallikrein in plasma (BOL 148 1.0-4.0 mg/kg; methysergide 0.10-0.60 mg/kg; ergotamine 0.10-0.60 mg/kg). Serotonin 41-50 coagulation factor XII Rattus norvegicus 93-103 7515401-1 1994 In mammals, a large proportion of the bulbospinal 5-hydroxytryptamine (5-HT) neurons also contain neuropeptides, such as substance P (SP) and galanin (GAL). Serotonin 50-69 galanin prepropeptide, gene 2 L homeolog Xenopus laevis 142-149 6159456-2 1980 The 5-hydroxytryptamine metabolite 5-hydroxyindoleacetic acid was also raised in the CSF. Serotonin 4-23 colony stimulating factor 2 Homo sapiens 85-88 6154406-0 1980 A comparison of the effects of intravenous serotonin and dextran on the levels of factor XII, prekallikrein and plasminogen in rat plasma. Serotonin 43-52 coagulation factor XII Rattus norvegicus 82-92 7515401-1 1994 In mammals, a large proportion of the bulbospinal 5-hydroxytryptamine (5-HT) neurons also contain neuropeptides, such as substance P (SP) and galanin (GAL). Serotonin 50-69 galanin prepropeptide, gene 2 L homeolog Xenopus laevis 151-154 6154406-0 1980 A comparison of the effects of intravenous serotonin and dextran on the levels of factor XII, prekallikrein and plasminogen in rat plasma. Serotonin 43-52 plasminogen Rattus norvegicus 112-123 6154406-3 1980 The assay of PKA and Baee-esterase activities after gel filtration on Sephadex G-100 of acetone-activated plasma from rats treated with serotonin 0.10 mg/kg revealed reduced fragmentation of factor XII, and reduced levels of kallikrein and of an additional BAEe-esterase. Serotonin 136-145 coagulation factor XII Rattus norvegicus 191-201 2471111-2 1989 The antinociceptive effect of substance P, given intraventricularly, in rats and mice was blocked after depletion of 5-HT in the spinal cord with the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) or with the inhibitor of the synthesis of 5-HT, p-chlorophenylalanine (PCPA), but not after depletion of NA in the spinal cord with the neurotoxin 6-hydroxydopamine (6-OHDA). Serotonin 117-121 tachykinin 1 Mus musculus 30-41 2471111-2 1989 The antinociceptive effect of substance P, given intraventricularly, in rats and mice was blocked after depletion of 5-HT in the spinal cord with the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) or with the inhibitor of the synthesis of 5-HT, p-chlorophenylalanine (PCPA), but not after depletion of NA in the spinal cord with the neurotoxin 6-hydroxydopamine (6-OHDA). Serotonin 237-241 tachykinin 1 Mus musculus 30-41 6154406-4 1980 Serotonin also lowered the plasminogen level. Serotonin 0-9 plasminogen Rattus norvegicus 27-38 27520521-5 1994 The serotonin (5-hydroxytryptarnine; 5-HT) system may be involved in these reactions.The best management of such reactions will involve counselling patients beforehand about the possibility of these reactions, stopping treatment with the agents if such a reaction is suspected, or adding an agent with 5-HT1A antagonistic properties (e.g. propranolol) to the treatment regimen. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 302-308 6154406-6 1980 Evidence was provided that serotonin did not lower the plasma level of factor XII of the coagulation system, but the level of a factor of significance for the activation of factor XII. Serotonin 27-36 coagulation factor XII Rattus norvegicus 173-183 2473488-4 1989 Studies reporting negative associations between low CSF levels of the serotonin metabolite 5-HIAA and personality traits of aggressiveness and hostility are reviewed. Serotonin 70-79 colony stimulating factor 2 Homo sapiens 52-55 92532-7 1979 These studies were based on CSF metabolite levels and provided evidence for a high serotonin metabolite (5HIAA) level. Serotonin 83-92 colony stimulating factor 2 Homo sapiens 28-31 8074747-0 1994 Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. Serotonin 84-93 neurotrophin 3 Rattus norvegicus 38-52 2616793-4 1989 In suicidal patients, regardless of diagnoses, analyses of monoamine metabolites in lumbar CSF reveal decreased concentrations of the serotonin metabolite 5-HIAA. Serotonin 134-143 colony stimulating factor 2 Homo sapiens 91-94 8028772-0 1994 Serotonin innervation of enkephalin containing neurones in the rat spinal trigeminal nucleus. Serotonin 0-9 proenkephalin Rattus norvegicus 25-35 264087-1 1979 Ceruloplasmin, the blue copper-protein of the blood plasma, is believed by some workers to be involved in the metabolic management of 5-hydroxytryptamine (serotonin) during pregnancy. Serotonin 134-153 ceruloplasmin Homo sapiens 0-13 264087-1 1979 Ceruloplasmin, the blue copper-protein of the blood plasma, is believed by some workers to be involved in the metabolic management of 5-hydroxytryptamine (serotonin) during pregnancy. Serotonin 155-164 ceruloplasmin Homo sapiens 0-13 11224250-0 1994 Noradrenaline-serotonin interactions in the anxiolytic effects of 5-HT(1A) agonists. Serotonin 14-23 5-hydroxytryptamine receptor 1A Homo sapiens 66-73 738767-1 1978 Rabbit basophil-derived platelet activating factor (PAF), a mediator of anaphylaxis, induces the aggregation and release of serotonin from rabbit platelets. Serotonin 124-133 PCNA clamp associated factor Homo sapiens 52-55 738767-2 1978 In the present study, we report that PAF obtained by challenge of specifically sensitized rabbit basophils induced the noncytotoxic release of serotonin from human platelets; maximal extent of release ranged between 34-46%. Serotonin 143-152 PCNA clamp associated factor Homo sapiens 37-40 2525822-4 1989 In competition experiments 8-OH-DPAT, TFMPP, mesulergine, DOB, and ICS 205-930 had low affinity for 3H-5HT-labeled 5HT1D sites, indicating that the pharmacology of the 5HT1D site is distinct from previously identified 5HT1A, 5HT1B, 5HT1C, 5HT2, and 5HT3 sites. Serotonin 103-106 5-hydroxytryptamine receptor 1A Bos taurus 218-223 3402556-4 1988 When r-EPo was added to the culture system on day 3 after megakaryocytic colony formation with PWM-SCM, the serotonin content in megakaryocytes increased markedly but ATP content and Ach-E activity did not increase significantly. Serotonin 108-117 erythropoietin Mus musculus 7-10 7513040-7 1994 In both groups of stressed animals an inverse correlation between tPA activity and blood serotonin was observed. Serotonin 89-98 plasminogen activator, tissue type Rattus norvegicus 66-69 2458513-9 1988 A logarithmic model indicated a positive correlation between the two serotonin markers studied, i.e., the amount of platelet-bound 5-HT and the CSF concentrations of 5-HIAA. Serotonin 69-78 colony stimulating factor 2 Homo sapiens 144-147 720481-0 1978 Effect of the administration of (d-Ala) 2methionine-enkephalin on the serotonin metabolism in rat brain. Serotonin 70-79 proenkephalin Rattus norvegicus 52-62 8124521-8 1993 Although not yet conclusively identified by specific cytochemical markers, the gp120-responsive cells resemble type-2 astrocytes and differ from neurons and type-1 astrocytes both in gross phenotype and in a number of receptor/channel properties: positivity to AMPA and cholinergic agonists; negativity to NMDA, serotonin and high KCl. Serotonin 312-321 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 79-84 100343-4 1978 Human plasma cholinesterase was also inhibited by serotonin and tryptamine. Serotonin 50-59 butyrylcholinesterase Homo sapiens 13-27 100343-5 1978 In contrast to these animal enzymes, the cholinesterase of Pseudomonas aeruginosa was refractory to serotonin and its derivatives under the same experimental conditions. Serotonin 100-109 butyrylcholinesterase Homo sapiens 41-55 365126-4 1978 The imipramine-induced alteration in CSF levels of the serotonin metabolite (5-hydroxy-indoleacetic acid [5HIAA]) correlated with imipramine levels but not with desipramine. Serotonin 55-64 colony stimulating factor 2 Homo sapiens 37-40 2843792-0 1988 Inhibitory action of serotonin in CA1 hippocampal neurons in vitro. Serotonin 21-30 carbonic anhydrase 1 Rattus norvegicus 34-37 2843792-1 1988 The ionic mechanism of the inhibitory effect of serotonin was investigated in vitro in the CA1 region of the rat hippocampus by extra- and intracellular recordings. Serotonin 48-57 carbonic anhydrase 1 Rattus norvegicus 91-94 2465543-0 1988 Interactions of substance P antagonists with serotonin in the mouse spinal cord. Serotonin 45-54 tachykinin 1 Mus musculus 16-27 2465543-1 1988 Administered intrathecally (IT) to mice, the putative substance P antagonist [D-Pro2,D-Trp7,9-substance P (DPDT) blocked substance P- and serotonin-induced reciprocal hindlimb scratching with ID50 values of 4.6 (2.9-6.9) and 3.0 (1.9-4.8) micrograms, respectively. Serotonin 138-147 tachykinin 1 Mus musculus 54-65 2465543-1 1988 Administered intrathecally (IT) to mice, the putative substance P antagonist [D-Pro2,D-Trp7,9-substance P (DPDT) blocked substance P- and serotonin-induced reciprocal hindlimb scratching with ID50 values of 4.6 (2.9-6.9) and 3.0 (1.9-4.8) micrograms, respectively. Serotonin 138-147 tachykinin 1 Mus musculus 94-105 2465543-1 1988 Administered intrathecally (IT) to mice, the putative substance P antagonist [D-Pro2,D-Trp7,9-substance P (DPDT) blocked substance P- and serotonin-induced reciprocal hindlimb scratching with ID50 values of 4.6 (2.9-6.9) and 3.0 (1.9-4.8) micrograms, respectively. Serotonin 138-147 tachykinin 1 Mus musculus 94-105 409301-4 1977 In the unipolar group, the TSH response showed a significant negative correlation with the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the CSF. Serotonin 91-100 colony stimulating factor 2 Homo sapiens 155-158 8288316-7 1993 At this low dose, serotonin stimulated splenic T-cell proliferation in response to IL-2, and enhanced both proliferation and IL-2 production in response to a suboptimal concentration of Con A. Serotonin 18-27 interleukin 2 Mus musculus 83-87 919375-1 1977 Inhibition of monoamine oxidase (substrates tyramine or serotonin) with simultaneous appearance of diamine oxidase (substrates histamine or putrescine) and distinct increase in AMP-deaminating activities were found after total body X-ray irradiation (700 r) of white mice or rats in mitochondrial fractions isolated from their liver and intestines. Serotonin 56-65 amine oxidase, copper-containing 1 Mus musculus 99-114 8288316-7 1993 At this low dose, serotonin stimulated splenic T-cell proliferation in response to IL-2, and enhanced both proliferation and IL-2 production in response to a suboptimal concentration of Con A. Serotonin 18-27 interleukin 2 Mus musculus 125-129 3154691-2 1988 Upon stimulation by various factors (viscous drag from increased flow, pulsatile stretch, ADP/ATP, norepinephrine, serotonin), the coronary endothelium releases a vasodilator called endothelium-derived relaxant factor (EDRF). Serotonin 115-124 alpha hemoglobin stabilizing protein Homo sapiens 219-223 7906471-3 1993 NPY affected the release of [3H]-glycine, [3H]-dopamine, [3H]-5-hydroxytryptamine, and [3H]-choline chloride-derived radioactivity in rabbit retina and of [3H]-GABA, [3H]-5-hydroxytryptamine and [3H]-choline chloride-derived radioactivity in chicken retina in an energy requiring, NA+K(+)-ATPase dependent and calcium dependent manner. Serotonin 62-81 neuropeptide Y Oryctolagus cuniculus 0-3 3412497-0 1988 Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex. Serotonin 45-54 histamine receptor H3 Rattus norvegicus 0-21 401360-0 1977 Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine. Serotonin 101-110 gonadotropin releasing hormone 1 Rattus norvegicus 49-86 8280187-2 1993 Previous studies show that native LDL immediately and reversibly inhibit acetylcholine-evoked EDRF responses in rabbit aortic ring precontracted with noradrenaline or serotonin whereas Cu(2+)-oxidised LDL (oxLDL) inhibit relaxations after 30 min with a potency that varies with the donor. Serotonin 167-176 alpha hemoglobin stabilizing protein Homo sapiens 94-98 831826-8 1977 The phenolic amines, octopamine, synephrine, serotonin and tyramine, stimulated tRNA methylation slightly while inhibiting histone methylation by both liver and brain extracts and these effects showed no age dependency. Serotonin 45-54 Trng Rattus norvegicus 80-84 3340083-5 1988 FNPA acted as a competitive inhibitor for human placental MAO-A in the dark (Ki = 10 microM) when [14C]serotonin was used as the substrate. Serotonin 103-112 monoamine oxidase A Homo sapiens 58-63 7685343-10 1993 In consequence, the concerted action of IL-3 and KL on the GTP cyclohydrolase I and the tryptophan 5-monooxygenase reaction enhances the production of serotonin to about 20-fold levels. Serotonin 151-160 kit ligand Mus musculus 49-51 3340083-7 1988 The specificity of the photodependent incorporation of FNPA to MAO-A was shown by the protective effect of serotonin during the irradiation. Serotonin 107-116 monoamine oxidase A Homo sapiens 63-68 871531-4 1977 Contractions produced by exogenous norepinephrine or serotonin in a potassium-free bath were also made to relax by the addition of potassium. Serotonin 53-62 neurogenin 3 Rattus norvegicus 106-111 7685343-10 1993 In consequence, the concerted action of IL-3 and KL on the GTP cyclohydrolase I and the tryptophan 5-monooxygenase reaction enhances the production of serotonin to about 20-fold levels. Serotonin 151-160 GTP cyclohydrolase 1 Mus musculus 59-79 7685343-11 1993 Additionally, KL specifically causes the release of about half of total serotonin produced. Serotonin 72-81 kit ligand Mus musculus 14-16 1005744-6 1976 Incubation of platelets with phospholipase A2 leads to serotonin release. Serotonin 55-64 phospholipase A2 group IB Rattus norvegicus 29-45 2451975-0 1988 Reciprocal modulation of calcium current by serotonin and dopamine in the identified Aplysia neuron R15. Serotonin 44-53 ribonuclease A family member 2 Rattus norvegicus 100-103 7684621-9 1993 Prevention of PMN-platelet contact significantly potentiated the inhibitory effect of alpha 1-protease inhibitor on subsequent cathepsin G-induced platelet serotonin release. Serotonin 156-165 cathepsin G Homo sapiens 127-138 2451975-1 1988 Voltage-clamp methods were employed to study the effects of serotonin (5-HT) and dopamine on the pharmacologically isolated calcium current in the identified Aplysia neuron R15 grown in cell culture. Serotonin 60-69 ribonuclease A family member 2 Rattus norvegicus 173-176 2901381-5 1988 Development of 5HT agonists and antagonists selective for different 5HT receptor sub-types (5HT1A, 5HT1B, 5HT2, 5HT3) has opened a new avenue for investigation of the potential role of 5HT in anxiety. Serotonin 15-18 5-hydroxytryptamine receptor 1A Homo sapiens 92-97 185046-2 1976 The activity of kidney ornithine decarboxylase was also enhanced by other hormones, such as pentagastrin and serotonin, which, although they are not known to modify kidney physiology, are secreted by cells having close relationships to the calcitonin-secreting parafollicular cells. Serotonin 109-118 ornithine decarboxylase 1 Rattus norvegicus 23-46 185046-5 1976 The maximal stimulation of kidney ornithine decarboxylase activity by parathyroid hormone, calcitonin, vasopressin, L-triiodothyronine, pentagastrin, and serotonin occurred at 4 h after the hormone injection. Serotonin 154-163 ornithine decarboxylase 1 Rattus norvegicus 34-57 8492147-0 1993 Serotonin-operated potassium current in CA1 neurons dissociated from rat hippocampus. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 40-43 1001240-0 1976 [Cerebral metabolism of dopamine and of serotonin during Alzheimer and Pick"s diseases. Serotonin 40-49 protein interacting with PRKCA 1 Homo sapiens 71-75 3125819-4 1987 Washed platelets incubated with Cd2+ showed a general increase in protein phosphorylation concurrent with a slow release of serotonin. Serotonin 124-133 CD2 molecule Homo sapiens 32-35 3125819-6 1987 The phosphorylation of two proteins with molecular masses close to 43 and 20 kDa was more sensitive to the inhibitory effect of Cd2+, and under similar conditions, the primary effect of Cd2+ on serotonin release was inhibitory, although at lower Cd2+ concentrations a slight stimulation was noted. Serotonin 194-203 CD2 molecule Homo sapiens 128-131 3125819-6 1987 The phosphorylation of two proteins with molecular masses close to 43 and 20 kDa was more sensitive to the inhibitory effect of Cd2+, and under similar conditions, the primary effect of Cd2+ on serotonin release was inhibitory, although at lower Cd2+ concentrations a slight stimulation was noted. Serotonin 194-203 CD2 molecule Homo sapiens 186-189 3125819-6 1987 The phosphorylation of two proteins with molecular masses close to 43 and 20 kDa was more sensitive to the inhibitory effect of Cd2+, and under similar conditions, the primary effect of Cd2+ on serotonin release was inhibitory, although at lower Cd2+ concentrations a slight stimulation was noted. Serotonin 194-203 CD2 molecule Homo sapiens 186-189 4700496-2 1973 Aggregated IgG1, IgG2, IgG3, IgG4, and normal IgG complexes all aggregated platelets and caused release of serotonin to similar extents. Serotonin 107-116 immunoglobulin heavy constant gamma 3 (G3m marker) Homo sapiens 23-27 4700496-5 1973 Addition of fresh serum inhibited the release of serotonin caused by aggregated IgG1 and IgG3 proteins and normal IgG antigen-antibody complexes by about 50% but had no effect upon the release of serotonin obtained with IgG2 and IgG4 proteins. Serotonin 49-58 immunoglobulin heavy constant gamma 3 (G3m marker) Homo sapiens 89-93 8472855-1 1993 Recent studies have shown that serotonin (5-hydroxytryptamine; 5-HT) is required for the induction of interstitial collagenase in cultured rat and human myometrial smooth muscle cells. Serotonin 31-40 matrix metallopeptidase 1 Rattus norvegicus 102-126 8472855-1 1993 Recent studies have shown that serotonin (5-hydroxytryptamine; 5-HT) is required for the induction of interstitial collagenase in cultured rat and human myometrial smooth muscle cells. Serotonin 42-61 matrix metallopeptidase 1 Rattus norvegicus 102-126 4993759-0 1971 [Relationship between ceruloplasmin and serotonin (5-HT). Serotonin 40-49 ceruloplasmin Homo sapiens 22-35 1281037-1 1992 Injection of amylin (diabetes-associated peptide) into the hypothalamus induces anorexia, increases brain metabolism of dopamine and serotonin and elevates brain level of tryptophan. Serotonin 133-142 islet amyloid polypeptide Rattus norvegicus 13-19 13597237-0 1958 [Inactivation of serotonin by ceruloplasmin]. Serotonin 17-26 ceruloplasmin Homo sapiens 30-43 2832770-0 1987 Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Serotonin 81-100 5-hydroxytryptamine receptor 1A Homo sapiens 129-135 1281037-1 1992 Injection of amylin (diabetes-associated peptide) into the hypothalamus induces anorexia, increases brain metabolism of dopamine and serotonin and elevates brain level of tryptophan. Serotonin 133-142 islet amyloid polypeptide Rattus norvegicus 21-48 3444481-12 1987 The B2 receptor antagonists, D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Phe-Thi-Arg-TEA and D-Pro-Phe-Arg-heptylamide produced significant antagonism of the bradykinin-induced pain responses at doses which had no effect against 5-hydroxytryptamine or potassium chloride. Serotonin 217-236 bradykinin receptor B2 Homo sapiens 4-15 13486052-0 1957 Oxidation of serotonin in the presence of ceruloplasmin. Serotonin 13-22 ceruloplasmin Homo sapiens 42-55 1281037-3 1992 Hypothalamic and striatal serotonin metabolism also appeared to be increased following the amino acid-amylin treatment combination. Serotonin 26-35 islet amyloid polypeptide Rattus norvegicus 102-108 34006301-5 2021 Western blotting Immunoprecipitation and immunofluorescence was utilized to research the serotonylation of mTOR by serotonin and serotonin transporter inhibition. Serotonin 115-124 mechanistic target of rapamycin kinase Mus musculus 107-111 1281037-4 1992 These results suggest that amylin may increase transport of tyrosine and tryptophan into the brain, and that the increased availability of tryptophan may contribute to increased serotonin turnover observed following intrahypothalamic amylin treatment. Serotonin 178-187 islet amyloid polypeptide Rattus norvegicus 234-240 34006301-5 2021 Western blotting Immunoprecipitation and immunofluorescence was utilized to research the serotonylation of mTOR by serotonin and serotonin transporter inhibition. Serotonin 129-138 mechanistic target of rapamycin kinase Mus musculus 107-111 1446239-0 1992 The physiological effects of serotonin are mediated by the 5HT1A receptor in the cat"s cerebellar cortex. Serotonin 29-38 5-hydroxytryptamine receptor 1A Homo sapiens 59-73 34006301-9 2021 Mechanistically, targeting serotonin transporter suppressed mTOR serotonylation, leading to mTOR inactivation and increased tryptophan uptake. Serotonin 27-36 mechanistic target of rapamycin kinase Mus musculus 60-64 34006301-9 2021 Mechanistically, targeting serotonin transporter suppressed mTOR serotonylation, leading to mTOR inactivation and increased tryptophan uptake. Serotonin 27-36 mechanistic target of rapamycin kinase Mus musculus 92-96 2894798-1 1987 Ornithine decarboxylase activity of rat lung was induced by s.c. injection of acetylcholine, norepinephrine, epinephrine, dopamine, serotonin, vasopressin, angiotensin II, and adrenocorticotropic hormone, but not by gonadotropin, aldosterone, corticosterone or hydrocortisone. Serotonin 132-141 ornithine decarboxylase 1 Rattus norvegicus 0-23 2443817-3 1987 Aggressive and impulsive individuals have been shown to have low levels of the major CSF metabolite of serotonin, 5-hydroxyindoleacetic acid. Serotonin 103-112 colony stimulating factor 2 Homo sapiens 85-88 33990379-9 2021 We further demonstrated that MAO-A restrains antitumor T cell immunity through controlling intratumoral T cell autocrine serotonin signaling. Serotonin 121-130 monoamine oxidase A Homo sapiens 29-34 1446239-10 1992 Iontophoretic application of the 5HT1A agonists, 8-OH-DPAT and ipsapirone, mimic the suppressive action of serotonin in a dose-dependent manner. Serotonin 107-116 5-hydroxytryptamine receptor 1A Homo sapiens 33-38 3620949-1 1987 The activity of two pineal enzymes serotonin N-acetyltransferase (SNAT) and hydroxyindole-O-methyltransferase, (HIOMT) and the pineal content of serotonin (5-HT) and N-acetylserotonin (NAS) were measured in several strains of mice (Mus domesticus) in order to compare melatonin synthetic pathways among them. Serotonin 35-44 arylalkylamine N-acetyltransferase Mus musculus 66-70 1446239-11 1992 This response, as well as the 5HT mediated suppression are blocked by the application of spiperone, a 5HT1A antagonist. Serotonin 30-33 5-hydroxytryptamine receptor 1A Homo sapiens 102-107 1377048-5 1992 Expression of granulophysin on the platelet surface paralleled dense granule secretion as measured by 14C-serotonin release under conditions in which lysosomal granule release, as measured by beta-glucuronidase secretion, was less than 5%. Serotonin 106-115 CD63 molecule Homo sapiens 14-27 3600775-4 1987 Using voltage-clamp methods and new ligands that are selective for subtypes of serotonin receptors, we have been able to clarify the mechanism of serotonin action on CA1 cells in rat hippocampal slices. Serotonin 79-88 carbonic anhydrase 1 Rattus norvegicus 166-169 33881855-1 2021 The stereoselective total synthesis of the proposed structure of a potent serotonin 5-HT1A receptor agonist uncarialin A (1) is described. Serotonin 74-83 5-hydroxytryptamine receptor 1A Homo sapiens 84-99 33871963-2 2021 Monoamine oxidase, catechol-O-methyltransferase, and aldehyde dehydrogenase 2 (ALDH2) are important enzymes in the metabolism of dopamine (DA) and serotonin (5-HT); however, the role of ALDH2 in MA addiction remains unclear. Serotonin 147-156 catechol-O-methyltransferase Rattus norvegicus 19-47 33871963-2 2021 Monoamine oxidase, catechol-O-methyltransferase, and aldehyde dehydrogenase 2 (ALDH2) are important enzymes in the metabolism of dopamine (DA) and serotonin (5-HT); however, the role of ALDH2 in MA addiction remains unclear. Serotonin 158-162 catechol-O-methyltransferase Rattus norvegicus 19-47 3612533-3 1987 CV-6209 inhibited [3H]serotonin release from rabbit platelets stimulated with PAF (3 X 10(-8) M) with a similar potency as the inhibition on the platelet aggregation. Serotonin 22-31 PCNA clamp associated factor Homo sapiens 78-81 1383617-6 1992 These results suggest that ET-1 may cause pulmonary hypertension through a direct vasoconstrictor action and potentiation of serotonin-induced contraction, which may involve the 5-lipoxygenase pathway. Serotonin 125-134 arachidonate 5-lipoxygenase Rattus norvegicus 178-192 33931727-7 2021 We found that nonaggressive mice exhibit higher levels of IL-1beta in the dorsal raphe nucleus (DRN), the major source of forebrain serotonin (5-HT), compared to aggressive mice. Serotonin 132-141 interleukin 1 alpha Mus musculus 58-66 1425930-3 1992 The present study shows that different heparin preparations (50 nM) completely prevent human platelet aggregation, serotonin release and thromboxane B2 production induced by purified neutrophil-derived cathepsin G (E.C. Serotonin 115-124 cathepsin G Homo sapiens 202-213 33931727-7 2021 We found that nonaggressive mice exhibit higher levels of IL-1beta in the dorsal raphe nucleus (DRN), the major source of forebrain serotonin (5-HT), compared to aggressive mice. Serotonin 143-147 interleukin 1 alpha Mus musculus 58-66 33931727-9 2021 Aggressive mice also exhibited higher c-Fos expression in 5-HT neurons in the DRN compared to nonaggressive mice. Serotonin 58-62 FBJ osteosarcoma oncogene Mus musculus 38-43 33931727-10 2021 In line with these findings, deletion of IL-1 receptor in the DRN enhanced c-Fos expression in 5-HT neurons during aggressive encounters, suggesting that modulation of 5-HT neuronal activity by IL-1beta signaling in the DRN controls expression of aggressive behavior. Serotonin 95-99 FBJ osteosarcoma oncogene Mus musculus 75-80 33931727-10 2021 In line with these findings, deletion of IL-1 receptor in the DRN enhanced c-Fos expression in 5-HT neurons during aggressive encounters, suggesting that modulation of 5-HT neuronal activity by IL-1beta signaling in the DRN controls expression of aggressive behavior. Serotonin 168-172 FBJ osteosarcoma oncogene Mus musculus 75-80 33931727-10 2021 In line with these findings, deletion of IL-1 receptor in the DRN enhanced c-Fos expression in 5-HT neurons during aggressive encounters, suggesting that modulation of 5-HT neuronal activity by IL-1beta signaling in the DRN controls expression of aggressive behavior. Serotonin 168-172 interleukin 1 alpha Mus musculus 194-202 1413625-4 1992 In the system containing membrane bound MAO from human placenta, where the MAO-A is predominating, the modulators studied mostly inhibited deamination of 14C-serotonin. Serotonin 158-167 monoamine oxidase A Homo sapiens 75-80 1535274-9 1992 Serotonin immunocytochemistry performed at one month revealed normal fiber distribution in the cortex but a loss of fibers in the CA1 and CA2 hippocampal fields. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 130-133 33883037-2 2021 As partial agonist of the dopamine (D2) and serotonin (5-HT1A) receptors, it appears to be effective in reducing mania in patients with bipolar disorder, tics in Tourette Syndrome, aggression in schizophrenia and autism spectrum disorder. Serotonin 44-53 5-hydroxytryptamine receptor 1A Homo sapiens 55-61 2883548-2 1987 The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself. Serotonin 280-289 adrenoceptor alpha 1D Homo sapiens 42-49 2883548-2 1987 The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself. Serotonin 280-289 adrenoceptor alpha 1D Homo sapiens 144-151 2883548-2 1987 The theory suggests that final effects on alpha-1 mediated neurotransmission may be produced not only by drugs which have direct effects on the alpha-1 receptor or its second messenger, but also by drugs having effects on neurotransmitter systems such as acetylcholine, GABA, and serotonin, among others, which modulate the activity of central norepinephrine neurons or, via feedback mechanisms, by drugs having effects on adrenergic receptors other than the alpha-1 receptor itself. Serotonin 280-289 adrenoceptor alpha 1D Homo sapiens 144-151 1343264-5 1992 Even potential vasoconstrictors such as vasopressin, catecholamines and serotonin release EDRF. Serotonin 72-81 alpha hemoglobin stabilizing protein Homo sapiens 90-94 33935645-6 2021 Our data indicates that BDNF-TrkB signaling regulates the functional phenotype of 5-HT neurons with long-term behavioral consequences. Serotonin 82-86 brain derived neurotrophic factor Mus musculus 24-28 33859334-0 2021 Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice. Serotonin 0-9 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 55-95 33859334-6 2021 Here, we investigated the role of TRPV4 in 5-HT-induced plasma extravasation using pharmacological and genetic approaches. Serotonin 43-47 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 34-39 3106309-0 1987 Effects of cyclooxygenase inhibition on pulmonary vascular responses to serotonin. Serotonin 72-81 prostaglandin-endoperoxide synthase 1 Canis lupus familiaris 11-25 1722215-9 1991 Pretreatment of fundic and circular corpus preparations with VIP reduced the excitatory responses to substance P, bombesin, serotonin and histamine, but it had no effect on the acetylcholine (ACh)-induced tonic and phasic activity. Serotonin 124-133 vasoactive intestinal peptide Sus scrofa 61-64 33859334-8 2021 5-HT-mediated extravasation was significantly reduced by pharmacological inhibition of the 5-HT2A receptor subtype, or with antagonism or deletion of TRPV4, consistent with functional interaction between 5-HT receptors and TRPV4. Serotonin 0-4 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 150-155 33859334-8 2021 5-HT-mediated extravasation was significantly reduced by pharmacological inhibition of the 5-HT2A receptor subtype, or with antagonism or deletion of TRPV4, consistent with functional interaction between 5-HT receptors and TRPV4. Serotonin 0-4 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 223-228 3587377-1 1987 The triazolodiazepines brotizolam, triazolam and alprazolam inhibited PAF-induced human platelet aggregation in vitro (IC50 = 0.54, 7.6 and 13.7 microM, respectively) but showed only a weak or no effect against other aggregating agents (ADP, adrenaline, collagen, serotonin, arachidonic acid). Serotonin 264-273 PCNA clamp associated factor Homo sapiens 70-73 33782773-5 2021 Cloning and functional characterization of the polyspecific organic cation transporters OCT1 (SLC22A1), OCT2 (SLC22A2), OCT3 (SLC22A3) and the plasma membrane monoamine transporter PMAT (SLC29A4) revealed that every single transporter mediates low affinity uptake of NE, 5-HT, and DA. Serotonin 271-275 solute carrier family 29 member 4 Homo sapiens 181-185 1759390-7 1991 In deprenyl pretreated mitochondria the potency of MAO-A-dependent effects of these amines was: serotonin greater than tyramine much greater than much greater than 2-phenylethylamine. Serotonin 96-105 monoamine oxidase A Homo sapiens 51-56 33658309-12 2021 Using a vocal playback paradigm, we find that acutely increasing or systemically depleting available serotonin increased cFos immunoreactive neurons in the social behavior network (SBN) mice raised in social isolation compared to their socially reared counterparts. Serotonin 101-110 FBJ osteosarcoma oncogene Mus musculus 121-125 33705592-9 2021 CONCLUSIONS & INFERENCES: Serotonin-mediated activation of 5HT3A receptors in the spinal cord drives the development of enhanced female-specific VHS in our two hit CPS+CAS through up-regulation of spinal cord ERalpha. Serotonin 26-35 estrogen receptor 1 Rattus norvegicus 209-216 3100342-8 1987 As both prostaglandin I2 and acetylcholine-induced EDRF also inhibit platelet aggregation, endothelial injury and loss of these factors may predispose to vasospasm precipitated by release of platelet-derived mediators such as thromboxane A2 (TXA2) and 5-hydroxytryptamine. Serotonin 252-271 alpha hemoglobin stabilizing protein Homo sapiens 51-55 1679210-3 1991 The azapirones appear to act as serotonin 5-HT1A partial agonists as they all share high affinity for 5-HT1A binding sites in vitro as well as in anatomical studies. Serotonin 32-41 5-hydroxytryptamine receptor 1A Homo sapiens 42-48 2946301-12 1986 We conclude that the induction of PNMT by reserpine involves depletion of catecholamines and serotonin, the depletion of serotonin having the more powerful effect. Serotonin 93-102 phenylethanolamine-N-methyltransferase Rattus norvegicus 34-38 2946301-12 1986 We conclude that the induction of PNMT by reserpine involves depletion of catecholamines and serotonin, the depletion of serotonin having the more powerful effect. Serotonin 121-130 phenylethanolamine-N-methyltransferase Rattus norvegicus 34-38 33453675-0 2021 Role of peripheral 5-HT1D, 5-HT3 and 5-HT7 receptors in the mechanical allodynia induced by serotonin in mice. Serotonin 92-101 5-hydroxytryptamine (serotonin) receptor 1D Mus musculus 19-25 33453676-4 2021 Agomelatine is an agonist of the melatonin receptors MT1 and MT2 and an antagonist of the serotonin receptors 5HT2B and 5HT2C. Serotonin 90-99 5-hydroxytryptamine receptor 2B Rattus norvegicus 110-115 1678720-0 1991 Interaction of the alpha-adrenoceptor agonist oxymetazoline with serotonin 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D receptors. Serotonin 65-74 5-hydroxytryptamine receptor 1A Homo sapiens 75-81 33637971-0 2021 Making a tick protein talk as a serotonin sensor. Serotonin 32-41 bone morphogenetic protein receptor type 2 Homo sapiens 22-26 1900528-7 1991 Serotonin induced a rapid, transient increase of [Ca++]i followed by a sustained elevation above baseline for 5 minutes. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 50-56 33280212-2 2021 Serotonin (5-HT) plays an important role in the regulation of GI (gastrointestinal) secretion, motility and sensitivity. Serotonin 0-9 G protein subunit alpha i1 Homo sapiens 62-64 33280212-2 2021 Serotonin (5-HT) plays an important role in the regulation of GI (gastrointestinal) secretion, motility and sensitivity. Serotonin 11-15 G protein subunit alpha i1 Homo sapiens 62-64 3730298-7 1986 Platelets treated at 2 degrees C with soluble heat-aggregated IgG, which binds to the Fc gamma receptor, showed increased surface PA-IgG, but, after incubation at 37 degrees C, although [14C]serotonin was released, PA-IgG levels were no longer increased. Serotonin 191-200 Fc gamma receptor Ia Homo sapiens 86-103 1900528-8 1991 Additions of EGTA or verapamil had a small effect on the peak height of serotonin-induced [Ca++]i elevation, but the [Ca++]i level declined more quickly to the basal level in treated compared with control cells. Serotonin 72-81 carbonic anhydrase 1 Rattus norvegicus 91-97 3010492-7 1986 ELP suppressed the release of serotonin from platelets induced by thrombin, while it did not markedly suppress the release of serotonin induced by Ca2+ ionophore A23187. Serotonin 30-39 nuclear receptor subfamily 5 group A member 1 Homo sapiens 0-3 33627618-9 2021 Deamination by ADAR and ADARb1 enzymes induces conformational changes in the 5-HT2CR that decrease the G-protein-coupling activity, agonist affinity, and thus serotonin signaling. Serotonin 159-168 adenosine deaminase RNA specific Homo sapiens 15-19 1364820-4 1991 Rings of endothelium-denuded sheep middle cerebral artery precontracted with 5-hydroxytryptamine were relaxed by CGRP (maximum relaxation = 87.8 +/- 8.1%, pD2 = 7.81 +/- 0.12, n = 12) and by VIP (maximum relaxation = 55.1 +/- 4.1%, pD2 = 7.65 +/- 0.04, n = 18). Serotonin 77-96 vasoactive intestinal peptide Ovis aries 191-194 33672070-3 2021 For instance, a disruption and/or dysfunction in the 5-HT1A-FGFR1 heteroreceptor complexes in the raphe-hippocampal serotonin neuron systems can contribute to the development of MD. Serotonin 116-125 5-hydroxytryptamine receptor 1A Homo sapiens 53-59 2030808-4 1991 The release of EDRF evoked by serotonin is not prevented by 5HT2-serotonergic antagonists, and involves a pertussis toxin-sensitive G-protein. Serotonin 30-39 alpha hemoglobin stabilizing protein Homo sapiens 15-19 33672070-5 2021 Reduced 5-HT1A auto-receptor function, increased plasticity and trophic activity in the midbrain raphe 5-HT neurons can develop via agonist activation of allosteric receptor-receptor interactions in the 5-HT1A-FGFR1 heterocomplex. Serotonin 8-12 5-hydroxytryptamine receptor 1A Homo sapiens 203-209 2413384-5 1985 Serotonin is localized in those medullary cells which contain phenylethanolamine-N-methyltransferase, an enzyme which is necessary for the synthesis of epinephrine. Serotonin 0-9 phenylethanolamine-N-methyltransferase Rattus norvegicus 62-100 2030808-7 1991 The same is true for contractions evoked by aggregating platelets, which release enough serotonin to activate receptors on both the endothelial cells (release of EDRF) and on vascular smooth muscle (contraction). Serotonin 88-97 alpha hemoglobin stabilizing protein Homo sapiens 162-166 1756024-3 1991 Stimulated EDRF release may override the direct vasoconstrictor effects of other platelet products such as thromboxane and serotonin resulting in local vasodilatation. Serotonin 123-132 alpha hemoglobin stabilizing protein Homo sapiens 11-15 2996509-6 1985 Serotonin was not detected in any control lung tissues, but was detected in all the nine SCC samples, but dopamine was detected only in three out of nine SCC samples. Serotonin 0-9 serpin family B member 3 Homo sapiens 89-92 33591947-5 2021 We found an elevation of serum IDO1 activity and decreased 5-HT in CUMS mice, and the serum IDO1 activity was negatively correlated with 5-HT level. Serotonin 137-141 indoleamine 2,3-dioxygenase 1 Mus musculus 92-96 33591947-9 2021 Thus, IDO1 hyperactivity played crucial roles in modulating 5-HT metabolism and BDNF function thereby impacting outcomes of hippocampal neurogenesis and BOLD signals in depressive disorder. Serotonin 60-64 indoleamine 2,3-dioxygenase 1 Mus musculus 6-10 1905186-0 1991 [Participation of 5-HT 1A receptors in the decrease by serotonin of activation of locus coeruleus neurons by glutamate]. Serotonin 55-64 5-hydroxytryptamine receptor 1A Homo sapiens 18-25 32901992-9 2021 5-HT treatment also augmented TNF-alpha-induced matrix metalloproteinase-3 expression, which was also attenuated by Htr2b knockdown. Serotonin 0-4 matrix metallopeptidase 3 Mus musculus 48-74 32745364-10 2021 CONCLUSIONS: Patients with NBCCS who experienced increased Shh signaling from the prenatal period showed significantly lower harm avoidance relate to serotonin. Serotonin 150-159 sonic hedgehog signaling molecule Homo sapiens 59-62 2861094-5 1985 The concentrations of serotonin in sera from patients with MTC or MEN-IIa without pheochromocytomas were not different from the concentrations measured in healthy subjects (P greater than 0.10). Serotonin 22-31 ret proto-oncogene Homo sapiens 66-73 3968977-1 1985 Superfusion of slices of rat dorsal hippocampus in vitro with serotonin (5-HT) reversibly decreases the amplitude of the CA1 population spike evoked by stimulation of stratum radiatum. Serotonin 62-71 carbonic anhydrase 1 Rattus norvegicus 121-124 1913239-0 1991 [Synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-HT1B and 5-HT1D binding sites of the central nervous system]. Serotonin 55-64 5-hydroxytryptamine receptor 1D Cavia porcellus 99-105 33448546-9 2021 F1-7 and F34-3 downregulated TRPV4 and upregulated TPH, whereas FWDG upregulated OR2A4 for promoting 5-HT secretion by ECs. Serotonin 101-105 coagulation factor V Mus musculus 0-4 1761183-2 1991 The rat paw oedema produced by a local injection of phospholipase A2 from Naja mocambique mocambique has been shown to be mainly driven by the liberation of serotonin and kinins. Serotonin 157-166 phospholipase A2 group IB Rattus norvegicus 52-68 33064264-5 2021 Treating C. elegans with a GRK2 inhibitor, the selective serotonin reuptake inhibitor paroxetine, resulted in increased acute oxidative stress resistance compared with another selective serotonin reuptake inhibitor, fluoxetine. Serotonin 57-66 G protein-coupled receptor kinase 2 Caenorhabditis elegans 27-31 33064264-5 2021 Treating C. elegans with a GRK2 inhibitor, the selective serotonin reuptake inhibitor paroxetine, resulted in increased acute oxidative stress resistance compared with another selective serotonin reuptake inhibitor, fluoxetine. Serotonin 186-195 G protein-coupled receptor kinase 2 Caenorhabditis elegans 27-31 32351191-0 2021 Lactoferrin suppresses decreased locomotor activities by improving dopamine and serotonin release in the amygdala of ovariectomized rats. Serotonin 80-89 lactotransferrin Rattus norvegicus 0-11 33126185-5 2021 The constructed electrochemical sensor for the detection of 5-hydroxytryptamine (STN) showed a wide working range (0.1-522.6 muM), high sensitivity (19.377 muA muM-1 cm-2), and nano-molar detection limit (3.1 nM). Serotonin 60-79 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 81-84 33383868-8 2020 Our findings provide novel insights into the physiological and pathological significance of serotonin/5-HT1A signaling in the region-specific regulation of the blood-brain barrier. Serotonin 92-101 5-hydroxytryptamine receptor 1A Homo sapiens 102-108 33337320-5 2020 We also demonstrate that chemogenetic or optogenetic stimulation of npvf-expressing neurons induces sleep in a manner that requires NPVF and serotonin in the RN. Serotonin 141-150 neuropeptide VF precursor Mus musculus 68-72 33337320-6 2020 Finally, we provide genetic evidence that NPVF acts upstream of serotonin in the RN to maintain normal sleep levels. Serotonin 64-73 neuropeptide VF precursor Mus musculus 42-46 32335129-2 2020 Previously, we could demonstrate that tropisetron, a classical serotonin receptor blocker, can modulate collagen synthesis and acts in vitro via the alpha7 nicotinic acetylcholine receptor (alpha7nAchR). Serotonin 63-72 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 190-201 32574581-2 2020 The best-documented gene implicated in aggression is MAOA (Monoamine oxidase A), which encodes the key enzyme for the degradation of serotonin and catecholamines. Serotonin 133-142 monoamine oxidase A Homo sapiens 53-57 32574581-2 2020 The best-documented gene implicated in aggression is MAOA (Monoamine oxidase A), which encodes the key enzyme for the degradation of serotonin and catecholamines. Serotonin 133-142 monoamine oxidase A Homo sapiens 59-78 33059577-9 2021 The 5-HT3RA inhibit the binding of serotonin to post synaptic 5-HT3R and increase its availability to other receptors like 5-HT1A, 1B and 1D as well as 5-HT2 receptors and produces anti-depressant-like effect. Serotonin 35-44 5-hydroxytryptamine receptor 1A Homo sapiens 123-129 32711293-3 2020 The system has successfully generated novel molecule structures with desired multiple target activities, among which high-ranking compound 3 was synthesized, and demonstrated potent activities against dopamine D2, serotonin 5-HT1A and 5-HT2A receptors. Serotonin 214-223 5-hydroxytryptamine receptor 1A Homo sapiens 224-230 32989196-15 2020 In addition, spinal serotonin receptors may be indirectly involved in the effect of NTSR1 agonist. Serotonin 20-29 neurotensin receptor 1 Rattus norvegicus 84-89 32652084-7 2020 Mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-HT synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-HT as compared to female mutants. Serotonin 85-89 methyl CpG binding protein 2 Mus musculus 0-5 32652084-7 2020 Mecp2 null mice, which responded poorly to fluoxetine in the rotarod, showed reduced 5-HT synthesis in the prefrontal cortex, hippocampus and striatum, and reduced efficacy of fluoxetine in raising extracellular 5-HT as compared to female mutants. Serotonin 212-216 methyl CpG binding protein 2 Mus musculus 0-5 32472388-1 2020 BACKGROUND: The serotonin 5-HT1A receptor (5-HT1AR) and metabotropic glutamate receptor 4 (mGlu4) have been implicated as sites of antipsychotic drug action. Serotonin 16-25 5-hydroxytryptamine receptor 1A Homo sapiens 26-41 32472388-1 2020 BACKGROUND: The serotonin 5-HT1A receptor (5-HT1AR) and metabotropic glutamate receptor 4 (mGlu4) have been implicated as sites of antipsychotic drug action. Serotonin 16-25 5-hydroxytryptamine receptor 1A Homo sapiens 43-50 32870377-0 2020 Expression of serotonin receptor HTR4 in glucagon-like peptide-1-positive enteroendocrine cells of the murine intestine. Serotonin 14-23 5 hydroxytryptamine (serotonin) receptor 4 Mus musculus 33-37 32870377-5 2020 In the epithelium, HTR2A, HTR2B, and HTR4 colocalized with 5-HT, and HTR4 colocalized with glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). Serotonin 59-63 5 hydroxytryptamine (serotonin) receptor 4 Mus musculus 37-41 32870377-6 2020 Murine intestinal organoids show a colocalization pattern that is similar to in vivo HTR2A and HTR4 with 5-HT, GLP-1, and PYY. Serotonin 105-109 5 hydroxytryptamine (serotonin) receptor 4 Mus musculus 95-99 32999279-5 2020 5-HT synapses and synaptic triads were identified as synaptophysin-stained sites on 5-HT axons located proximal to gephyrin-stained or PSD95-stained spines. Serotonin 0-4 synaptophysin Mus musculus 53-66 32999279-5 2020 5-HT synapses and synaptic triads were identified as synaptophysin-stained sites on 5-HT axons located proximal to gephyrin-stained or PSD95-stained spines. Serotonin 84-88 synaptophysin Mus musculus 53-66 32845149-0 2020 How Monoamine Oxidase A Decomposes Serotonin: An Empirical Valence Bond Simulation of the Reactive Step. Serotonin 35-44 monoamine oxidase A Homo sapiens 4-23 32697958-3 2020 Studies have shown that blockade of low-affinity/high-capacity transporters, such as organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT), with decynium-22 can produce antidepressant-like effects and inhibit serotonin clearance in brain when the serotonin transporter is pharmacologically or genetically compromised. Serotonin 243-252 solute carrier family 29 member 4 Homo sapiens 128-165 32697958-3 2020 Studies have shown that blockade of low-affinity/high-capacity transporters, such as organic cation transporters (OCTs) and the plasma membrane monoamine transporter (PMAT), with decynium-22 can produce antidepressant-like effects and inhibit serotonin clearance in brain when the serotonin transporter is pharmacologically or genetically compromised. Serotonin 243-252 solute carrier family 29 member 4 Homo sapiens 167-171 32892185-0 2021 The CA1 hippocampal serotonin alterations involved in anxiety-like behavior induced by sciatic nerve injury in rats. Serotonin 20-29 carbonic anhydrase 1 Rattus norvegicus 4-7 32892185-2 2021 The current study investigated the consequence of pain induced by peripheral neuropathy on the serotonin (5-HT) level of the CA1 region of the hippocampus, which is known as a potential reason, for anxiety associated with neuropathic pain. Serotonin 95-104 carbonic anhydrase 1 Rattus norvegicus 125-128 32892185-2 2021 The current study investigated the consequence of pain induced by peripheral neuropathy on the serotonin (5-HT) level of the CA1 region of the hippocampus, which is known as a potential reason, for anxiety associated with neuropathic pain. Serotonin 106-110 carbonic anhydrase 1 Rattus norvegicus 125-128 32892185-5 2021 To investigate the probable mechanisms, the in vivo extracellular levels of 5-HT were assessed by microdialysis and using reverse-phase high-pressure liquid chromatography (HPLC) in the CA1 region of hippocampus on days 16 and 30 post-CCI. Serotonin 76-80 carbonic anhydrase 1 Rattus norvegicus 186-189 32892185-7 2021 5-HT concentration in the CA1 region of the hippocampus significantly (F=43.8, p=0.000) reduced in CCI rats, when the pain threshold was minimum. Serotonin 0-4 carbonic anhydrase 1 Rattus norvegicus 26-29 32892185-10 2021 This effect accompanies the reduction in 5-HT concentration in the CA1 region of the hippocampus. Serotonin 41-45 carbonic anhydrase 1 Rattus norvegicus 67-70 32769108-11 2020 The CeA is reciprocally connected with the dorsal raphe nucleus (DRN), the main source of serotonin (5-HT) in the mammalian brain, and excessive 5-HT signaling is critically implicated in the etiology of alcohol use disorder (AUD). Serotonin 90-99 CEA cell adhesion molecule 5 Homo sapiens 4-7 32769108-11 2020 The CeA is reciprocally connected with the dorsal raphe nucleus (DRN), the main source of serotonin (5-HT) in the mammalian brain, and excessive 5-HT signaling is critically implicated in the etiology of alcohol use disorder (AUD). Serotonin 101-105 CEA cell adhesion molecule 5 Homo sapiens 4-7 32769108-11 2020 The CeA is reciprocally connected with the dorsal raphe nucleus (DRN), the main source of serotonin (5-HT) in the mammalian brain, and excessive 5-HT signaling is critically implicated in the etiology of alcohol use disorder (AUD). Serotonin 145-149 CEA cell adhesion molecule 5 Homo sapiens 4-7 32763186-3 2020 demonstrate that Piezo1 in ECs senses single-strand RNA (ssRNA) from intestinal microbiota to promote serotonin production. Serotonin 102-111 piezo type mechanosensitive ion channel component 1 Homo sapiens 17-23 32763186-4 2020 Deletion of Piezo1 in intestinal epithelium promotes bone formation, decreases peristalsis, and protects from colitis because of decreased serotonin. Serotonin 139-148 piezo type mechanosensitive ion channel component 1 Homo sapiens 12-18 32752885-1 2020 Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Serotonin 47-56 tryptophan hydroxylase 1 Homo sapiens 5-29 32752885-1 2020 Aim: Tryptophan hydroxylase 1 (TPH1) catalyzes serotonin synthesis in peripheral tissues. Serotonin 47-56 tryptophan hydroxylase 1 Homo sapiens 31-35 32752885-2 2020 Selective TPH1 inhibitors may be useful for treating disorders related to serotonin dysregulation. Serotonin 74-83 tryptophan hydroxylase 1 Homo sapiens 10-14 32752885-7 2020 Conclusion: This TPH1 inhibitor scaffold may be useful for developing new therapeutics for treating elevated peripheral serotonin. Serotonin 120-129 tryptophan hydroxylase 1 Homo sapiens 17-21 32483877-6 2020 Among them, a 5-hydroxytryptamine 5A (5-HT5A) receptor antagonist suppressed AR activity through protein kinase A signaling, which was confirmed by 5-HT5A receptor knockdown. Serotonin 14-33 5-hydroxytryptamine receptor 5A Homo sapiens 38-44 32248977-9 2020 Consistent with a previous in vitro study, leptin was found to promote expression of stathmin, a positive regulator of trophoblast invasion, and of serotonin receptors, potential mediators of offspring neurological development. Serotonin 148-157 leptin Mus musculus 43-49 32678079-3 2020 The serotonin 1-A receptor (5-HT1A) is an inhibitory G protein-coupled serotonin receptor encoded by the HTR1A gene that plays a role in regulating serotonin release, physiological stress responding, and emotional behavior. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 105-110 32678079-3 2020 The serotonin 1-A receptor (5-HT1A) is an inhibitory G protein-coupled serotonin receptor encoded by the HTR1A gene that plays a role in regulating serotonin release, physiological stress responding, and emotional behavior. Serotonin 71-80 5-hydroxytryptamine receptor 1A Homo sapiens 105-110 32678079-3 2020 The serotonin 1-A receptor (5-HT1A) is an inhibitory G protein-coupled serotonin receptor encoded by the HTR1A gene that plays a role in regulating serotonin release, physiological stress responding, and emotional behavior. Serotonin 71-80 5-hydroxytryptamine receptor 1A Homo sapiens 105-110 4044301-2 1985 In this study we have used electron microscopic immunocytochemical methods to study the subcellular distribution of serotonin and the enzyme responsible for epinephrine biosynthesis, phenylethanolamine-N-methyltransferase (PNMT). Serotonin 116-125 phenylethanolamine-N-methyltransferase Rattus norvegicus 183-221 4044301-2 1985 In this study we have used electron microscopic immunocytochemical methods to study the subcellular distribution of serotonin and the enzyme responsible for epinephrine biosynthesis, phenylethanolamine-N-methyltransferase (PNMT). Serotonin 116-125 phenylethanolamine-N-methyltransferase Rattus norvegicus 223-227 2984490-2 1985 GABA receptor agonists, by changing the firing rate of the corresponding neurons accelerate noradrenaline turnover without changes in postsynaptic receptor density and diminish serotonin liberation with an up-regulation of 5HT2 receptors. Serotonin 177-186 GABA type A receptor-associated protein Homo sapiens 0-13 3883231-3 1985 Synaptic contacts were observed between tritiated 5-hydroxytryptamine-labelled boutons and luteinizing hormone-releasing hormone-immunoreactive dendrites. Serotonin 50-69 gonadotropin releasing hormone 1 Rattus norvegicus 91-128 3883231-6 1985 These observations provide morphological basis for the idea that 5-hydroxytryptamine-containing neurons can act directly on luteinizing hormone-releasing hormone release. Serotonin 67-84 gonadotropin releasing hormone 1 Rattus norvegicus 124-161 2580262-1 1985 We have investigated the possible associations between the demographic, clinical and psychological characteristics of 80 patients with low back pain and the CSF levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the principal central nervous system metabolites of serotonin, dopamine and noradrenaline, and of tryptophan, the amino acid precursor of serotonin. Serotonin 328-337 colony stimulating factor 2 Homo sapiens 157-160 2580262-1 1985 We have investigated the possible associations between the demographic, clinical and psychological characteristics of 80 patients with low back pain and the CSF levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG), the principal central nervous system metabolites of serotonin, dopamine and noradrenaline, and of tryptophan, the amino acid precursor of serotonin. Serotonin 414-423 colony stimulating factor 2 Homo sapiens 157-160 6492080-3 1984 This paper presents structure-activity relationships for a series of cis-1-amino-4-(substituted-aryl)tetralins, which are surprisingly potent and selective inhibitors of serotonin uptake in in vitro models. Serotonin 170-179 suppressor of cytokine signaling 1 Homo sapiens 69-74 6510472-6 1984 Specific binding of [3H]PAF-acether in rabbit platelets correlated well with [3H]serotonin release in response to different doses of PAF-acether and with the uptake of calcium by the platelets. Serotonin 81-90 PCNA clamp associated factor Homo sapiens 24-27 6510472-6 1984 Specific binding of [3H]PAF-acether in rabbit platelets correlated well with [3H]serotonin release in response to different doses of PAF-acether and with the uptake of calcium by the platelets. Serotonin 81-90 PCNA clamp associated factor Homo sapiens 133-136 6084543-0 1984 Substance P-immunoreactive processes on 5HT/SP-immunoreactive medullary cells. Serotonin 40-43 tachykinin 1 Mus musculus 0-11 6084543-1 1984 Two-color immunoperoxidase staining has been used to localize substance P (SP)-immunoreactive processes on neurons in the caudal medulla that exhibited both serotonin (5HT)- and SP-immunoreactivity (5HTI/SPI cells). Serotonin 157-166 tachykinin 1 Mus musculus 62-73 6084543-1 1984 Two-color immunoperoxidase staining has been used to localize substance P (SP)-immunoreactive processes on neurons in the caudal medulla that exhibited both serotonin (5HT)- and SP-immunoreactivity (5HTI/SPI cells). Serotonin 157-166 tachykinin 1 Mus musculus 75-77 6084543-1 1984 Two-color immunoperoxidase staining has been used to localize substance P (SP)-immunoreactive processes on neurons in the caudal medulla that exhibited both serotonin (5HT)- and SP-immunoreactivity (5HTI/SPI cells). Serotonin 168-171 tachykinin 1 Mus musculus 62-73 6084543-1 1984 Two-color immunoperoxidase staining has been used to localize substance P (SP)-immunoreactive processes on neurons in the caudal medulla that exhibited both serotonin (5HT)- and SP-immunoreactivity (5HTI/SPI cells). Serotonin 168-171 tachykinin 1 Mus musculus 75-77 6084543-3 1984 This close association suggests that activity in bulbospinal 5HT/SP pathways, which can influence sympathetic preganglionic neurons, may be affected by the release of SP in the brainstem. Serotonin 61-64 tachykinin 1 Mus musculus 65-67 6084543-3 1984 This close association suggests that activity in bulbospinal 5HT/SP pathways, which can influence sympathetic preganglionic neurons, may be affected by the release of SP in the brainstem. Serotonin 61-64 tachykinin 1 Mus musculus 167-169 6508214-4 1984 In this paper the application of this method for the determination of serotonin in CSF, plasma, serum and urine is described. Serotonin 70-79 colony stimulating factor 2 Homo sapiens 83-86 6380618-1 1984 Investigation of the effects of injecting monoamines (noradrenaline, dopamine and serotonin) into the third ventricle of the brain on the LH-RH content in the synaptosomal fraction of the mediobasal hypothalamus in intact and castrated male rats has demonstrated that all the three monoamines are involved in the regulation of synthesis and secretion of LH-RH and that their effects on LH-RH-producing neurons are steroid-dependent. Serotonin 82-91 gonadotropin releasing hormone 1 Rattus norvegicus 138-143 6425292-5 1984 The presence of PAF in eosinophils was established by demonstrating the lipid nature of the compound, the RF value being identical with that of synthetic 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine on thin layer chromatograms, and by its ability to induce serotonin release from rabbit platelets. Serotonin 261-270 PCNA clamp associated factor Homo sapiens 16-19 6200802-2 1984 In 25 patients with Korsakoff"s disease, we found that CSF levels of metabolites of norepinephrine, dopamine, and serotonin were significantly lower than in controls. Serotonin 114-123 colony stimulating factor 2 Homo sapiens 55-58 6241253-1 1984 In vitro autoradiographic techniques combined with computer assisted microdensitometry were used to analyze the characteristics and distribution of multiple recognition sites for the neurotransmitters acetylcholine (M1 and M2) and serotonin (5-HT1A and 5-HT1B). Serotonin 231-240 5-hydroxytryptamine receptor 1A Homo sapiens 242-259 6335051-3 1984 The excess of serotonin in the brain created by means of 5-oxytryptophan fully prevented the acceleration of CRBA elaboration by enkephalin under the usual conditions. Serotonin 14-23 proenkephalin Rattus norvegicus 129-139 6320486-3 1983 The rate and degree of 3H-serotonin release by CLP is similar to that produced by thrombin. Serotonin 26-35 calmodulin like 3 Homo sapiens 47-50 6619916-0 1983 Storage of serotonin in vivo as a complex with serotonin-binding protein in central and peripheral serotonergic neurons. Serotonin 11-20 spermine binding protein Rattus norvegicus 47-72 6619916-2 1983 Experiments were undertaken to determine whether serotonin (5-HT) is physiologically stored as a complex with SBP in vivo. Serotonin 49-58 spermine binding protein Rattus norvegicus 110-113 6627525-3 1983 PAF releases serotonin from human thrombocytes within 1 min. Serotonin 13-22 PCNA clamp associated factor Homo sapiens 0-3 6345519-4 1983 Platelet shape change, formation of phosphatidic acid, and protein phosphorylation precede aggregation and are induced at lower concentrations of PAF than those required to induce release of serotonin and platelet aggregation. Serotonin 191-200 PCNA clamp associated factor Homo sapiens 146-149 6188804-0 1983 The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues. Serotonin 4-23 colony stimulating factor 2 Homo sapiens 101-104 6188804-2 1983 The 5-hydroxytryptamine antagonist ketanserin inhibited contractions of isolated human intracranial arteries, elicited by this CSF. Serotonin 4-23 colony stimulating factor 2 Homo sapiens 127-130 6827276-5 1983 Bovine hydroxyindole-O-methyltransferase showed a high specificity toward N-acetylserotonin, whereas chicken enzyme methylated N-acetylserotonin and, to some extent, serotonin and bufotenine. Serotonin 82-91 acetylserotonin O-methyltransferase Bos taurus 7-40 6401998-3 1983 2 The release of [14C]-serotonin induced by NaAA is more extensive in PRP from some individuals than from others. Serotonin 23-32 N-acylethanolamine acid amidase Homo sapiens 44-48 7118996-0 1982 Serotonin storage pools in basophil leukemia and mast cells: characterization of two types of serotonin binding protein and radioautographic analysis of the intracellular distribution of [3H]serotonin. Serotonin 0-9 spermine binding protein Rattus norvegicus 94-119 7121716-1 1982 Using serotonin and phenylethylamine deamination as measures of MAO A and MAO B activity respectively, positive correlations were observed between the activities of MAO A and MAO B in different areas of rhesus monkey and human brains. Serotonin 6-15 monoamine oxidase B Macaca mulatta 175-180 7046838-6 1982 In intact animals, serotonin had no effect on the content of LH-RH, while in the castrated animals, it produced an inhibitory action on the synthesis and secretion of LH-RH. Serotonin 19-28 gonadotropin releasing hormone 1 Rattus norvegicus 167-172 7071810-1 1982 A semi-synthetic 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine (alkylacetyl-GPC) was shown to be highly species selective in its capacity to cause platelet aggregation and serotonin release. Serotonin 173-182 glycophorin C Rattus norvegicus 77-80 32457073-8 2020 While genes significantly associated with CD via genome-wide methods were not differentially expressed, two of these genes (NDUFB9 and C1qL2) were part of a robust gene coexpression network associated with CUD involved in neurotransmission (GABA, acetylcholine, serotonin, and dopamine) and drug addiction. Serotonin 262-271 complement C1q like 2 Homo sapiens 135-140 32569126-3 2020 J Strength Cond Res XX(X): 000-000, 2020-This investigation determined whether variation in the HTR2A (serotonin receptor) gene modifies the ergogenic effects of caffeine on endurance and further modifies performance by the CYP1A2 genotype. Serotonin 103-112 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 224-230 32517612-4 2020 Our results further revealed that tph1 expression occurs exclusively in pro-opiomelanocortin (pomc)-expressing cells and that the resulting serotonin and its derivative melatonin inhibit the expression of the pituitary hormone genes, fshb, sl and tshb. Serotonin 140-149 follitropin subunit beta Oryzias latipes 234-238 32641996-10 2020 Specifically, inhibition of HDAC1 and HDAC3 by MS-275 strongly promoted Tph1 expression and endogenous serotonin synthesis in rat islets, concomitantly with enhanced insulin secretory capacity in vivo and ex vivo. Serotonin 103-112 histone deacetylase 3 Rattus norvegicus 38-43 32641996-18 2020 Conclusions: The present findings highlight a novel role of HDAC1-PKA-Tph1 signaling in governing beta-cell functional compensation by derepressing serotonin synthesis. Serotonin 148-157 histone deacetylase 1 Mus musculus 60-65 2052135-5 1991 Thus in a short period of time considerable knowledge has accumulated on how serotonin exerts its functions in the central nervous system via the 5-HT1A receptor. Serotonin 77-86 5-hydroxytryptamine receptor 1A Homo sapiens 146-161 32478146-4 2020 Here, we applied c-fos mapping to produce a comprehensive view of stress-activated brain regions in mice exposed to SPS alone or to SPS after oral pretreatment with the serotonin-noradrenaline receptor dual modulator ACH-000029 or the alpha1-adrenergic blocker prazosin. Serotonin 169-178 FBJ osteosarcoma oncogene Mus musculus 17-22 32088264-3 2020 Serotonin and other agonists induced robust decreases in fluorescence levels in the 5-HT1A/GIRK2- and 5-HT1B/GIRK2-HEK293 cells in a concentration-dependent manner in the assay, and these responses could be inhibited by selective 5-HT1A/5-HT1B antagonists and by the Galphai/o-protein inhibitor pertussis toxin (PTX). Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 84-90 32088264-3 2020 Serotonin and other agonists induced robust decreases in fluorescence levels in the 5-HT1A/GIRK2- and 5-HT1B/GIRK2-HEK293 cells in a concentration-dependent manner in the assay, and these responses could be inhibited by selective 5-HT1A/5-HT1B antagonists and by the Galphai/o-protein inhibitor pertussis toxin (PTX). Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 230-236 7056361-1 1982 The activities of monoamine oxidases A and B towards 5-hydroxytryptamine and beta-phenethylamine, respectively, were compared in the left and right caudatus, hippocampus, parietal cortex, cerebellum and frontal cortex 6 months after gamma-irradiation (single dose of 23 Gy) of either the right hemisphere or of the whole rabbit brain (in which case, a dose of l6 Gy). Serotonin 53-72 amine oxidase [flavin-containing] A Oryctolagus cuniculus 18-44 1871320-9 1991 Using a metabolic pathway approach, it can be shown that the best current candidate gene locus for a subtype of schizophrenia located on chromosome 5q11-13 (HGML10 # SCZD1 and OMIM #181510) is in the serotonergic pathway, i.e. a receptor for 5-hydroxytryptamine (subtype 1A; HGML10 #HTR1A) which also maps in the same chromosomal region. Serotonin 242-261 Schizophrenia susceptibility locus, chromosome 5-related Homo sapiens 166-171 6890835-0 1982 Inhibition of erythrocyte and plasma cholinesterase by 5-hydroxytryptamine. Serotonin 55-74 butyrylcholinesterase Homo sapiens 37-51 32242018-2 2020 In three cohorts of individuals with depression and treated with serotonin-norepinephrine reuptake inhibitor (N = 424) we show that responders, but not non-responders, display an increase of GPR56 mRNA in the blood. Serotonin 65-74 adhesion G protein-coupled receptor G1 Homo sapiens 191-196 1871320-9 1991 Using a metabolic pathway approach, it can be shown that the best current candidate gene locus for a subtype of schizophrenia located on chromosome 5q11-13 (HGML10 # SCZD1 and OMIM #181510) is in the serotonergic pathway, i.e. a receptor for 5-hydroxytryptamine (subtype 1A; HGML10 #HTR1A) which also maps in the same chromosomal region. Serotonin 242-261 5-hydroxytryptamine receptor 1A Homo sapiens 283-288 6890835-1 1982 The inhibition of human erythrocytes and plasma cholinesterase (ChE) by 5-hydroxytryptamine in vitro was studied. Serotonin 72-91 butyrylcholinesterase Homo sapiens 48-62 6890835-1 1982 The inhibition of human erythrocytes and plasma cholinesterase (ChE) by 5-hydroxytryptamine in vitro was studied. Serotonin 72-91 butyrylcholinesterase Homo sapiens 64-67 1701460-9 1990 In addition, the coexistence of 5HT with ENK appears to be much less common than the coexistence of 5HT with either SP or ppT. Serotonin 32-35 proenkephalin Rattus norvegicus 41-44 6890835-3 1982 The inhibition of RBCs and plasma ChE by 5-hydroxy-tryptamine was found to be of the competitive type. Serotonin 41-61 butyrylcholinesterase Homo sapiens 34-37 32146834-0 2020 Impact of host and environmental factors on beta-glucuronidase enzymatic activity: implications for gastrointestinal serotonin. Serotonin 117-126 glucuronidase, beta Mus musculus 44-62 32146834-6 2020 To demonstrate the functional effects of fecal enzymatic activity, we examined beta-glucuronidase-mediated cleavage of serotonin beta-d-glucuronide (5-HT-GLU) and the resultant production of free 5-HT by HPLC. Serotonin 119-128 glucuronidase, beta Mus musculus 79-97 32146834-6 2020 To demonstrate the functional effects of fecal enzymatic activity, we examined beta-glucuronidase-mediated cleavage of serotonin beta-d-glucuronide (5-HT-GLU) and the resultant production of free 5-HT by HPLC. Serotonin 149-153 glucuronidase, beta Mus musculus 79-97 32146834-14 2020 Our results demonstrate that altered beta-glucuronidase activity has implications for the bioavailability of luminal serotonin. Serotonin 117-126 glucuronidase, beta Mus musculus 37-55 7161149-2 1982 The pia mater covering the ventrolateral surface of the medulla oblongata is innervated by numerous varicose serotonin fibers originating from the serotonin neurons of the lower brainstem. Serotonin 109-118 RPTOR independent companion of MTOR complex 2 Homo sapiens 4-7 7161149-2 1982 The pia mater covering the ventrolateral surface of the medulla oblongata is innervated by numerous varicose serotonin fibers originating from the serotonin neurons of the lower brainstem. Serotonin 147-156 RPTOR independent companion of MTOR complex 2 Homo sapiens 4-7 2241900-1 1990 Short-term treatment of rat basophilic leukaemia (RBL-2H3) cells with the phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) activates protein kinase C (PKC) and results in the inhibition of the IgE-dependent formation of inositol phosphates, but in the potentiation of serotonin secretion. Serotonin 276-285 plasminogen activator, tissue type Rattus norvegicus 126-129 7161149-3 1982 Scattered serotonin fibers were observed in the pia mater in every part of the brain and spinal cord. Serotonin 10-19 RPTOR independent companion of MTOR complex 2 Homo sapiens 48-51 31636356-1 2020 Stimulation of the serotonin (5-HT)1A receptor (HTR1A) has been shown to contribute to the mechanism of action of some atypical antipsychotic drugs (APDs), including clozapine and lurasidone. Serotonin 19-28 5-hydroxytryptamine receptor 1A Homo sapiens 48-53 6170352-4 1981 Available evidence suggests that maximal inhibition of the efflux of the acidic metabolites of dopamine and serotonin from the CSF is not achieved with probenecid doses up to 100 mg/kg. Serotonin 108-117 colony stimulating factor 2 Homo sapiens 127-130 2226619-1 1990 Administration of serotonin (5-hydroxytryptamine, 5-HT) to pyramidal cells of the CA1 region of the hippocampus results in a hyperpolarizing response which is followed by a rebound depolarization and a decrease in the calcium-activated afterhyperpolarization (AHP). Serotonin 18-27 carbonic anhydrase 1 Rattus norvegicus 82-85 6779205-0 1981 Serotonin stimulates phosphorylation of protein I in the facial motor nucleus of rat brain. Serotonin 0-9 annexin A2 Rattus norvegicus 40-49 6779205-5 1981 We have now examined the facial motor nucleus and report here that serotonin produces a phosphorylation of Protein I when incubated with facial nucleus slices. Serotonin 67-76 annexin A2 Rattus norvegicus 107-116 31636356-1 2020 Stimulation of the serotonin (5-HT)1A receptor (HTR1A) has been shown to contribute to the mechanism of action of some atypical antipsychotic drugs (APDs), including clozapine and lurasidone. Serotonin 30-34 5-hydroxytryptamine receptor 1A Homo sapiens 48-53 32170814-0 2020 Deletion of murine slc29a4 modifies vascular responses to adenosine and 5-hydroxytryptamine in a sexually dimorphic manner. Serotonin 72-91 solute carrier family 29 (nucleoside transporters), member 4 Mus musculus 19-26 32170814-1 2020 Equilibrative nucleoside transporter 4 (ENT4), encoded by SLC29A4, mediates the flux of both 5-hydroxytryptamine (5-HT) and adenosine across cell membranes. Serotonin 93-112 solute carrier family 29 (nucleoside transporters), member 4 Mus musculus 0-38 32170814-1 2020 Equilibrative nucleoside transporter 4 (ENT4), encoded by SLC29A4, mediates the flux of both 5-hydroxytryptamine (5-HT) and adenosine across cell membranes. Serotonin 93-112 solute carrier family 29 (nucleoside transporters), member 4 Mus musculus 40-44 2226619-1 1990 Administration of serotonin (5-hydroxytryptamine, 5-HT) to pyramidal cells of the CA1 region of the hippocampus results in a hyperpolarizing response which is followed by a rebound depolarization and a decrease in the calcium-activated afterhyperpolarization (AHP). Serotonin 29-48 carbonic anhydrase 1 Rattus norvegicus 82-85 2335520-14 1990 Rapid phosphorylation of a human platelet protein of Mr 40,000-47,000 (P47), a substrate for protein kinase C activation, preceded secretion of serotonin when platelets were triggered by the most active heptaacyl MLA ion, m/z 1953. Serotonin 144-153 pleckstrin Homo sapiens 71-74 32174803-4 2020 NBOMe compounds are ultrapotent and highly efficacious agonists of serotonin 5-HT2A and 5-HT2C receptors (Ki values in low nanomolar range) with more than 1000-fold selectivity for 5-HT2A compared with 5-HT1A. Serotonin 67-76 5-hydroxytryptamine receptor 1A Homo sapiens 202-208 363273-5 1978 During this period, gastrin, cholecystokinin and secretin cells store the biogenic monoamine, 5-hydroxytryptamine a feature not displayed by the adult counter-parts of these cells. Serotonin 94-113 gastrin Homo sapiens 20-27 2335520-15 1990 These events were time-dependent, with half-maximal response of phosphorylation of P47 at 30 s and [14C]serotonin secretion at 45 s. A marked difference in the degree of phosphorylation of P47 was observed with heptaacyl MLA homolog present in TLC-8 inducing complete phosphorylation (97%), whereas less acylated Lipid A homologs present in TLC-1 caused marginal phosphorylation (20%). Serotonin 104-113 pleckstrin Homo sapiens 189-192 1981685-4 1990 Thus, their action closely resembles the action of serotonin in the same cell system, which is mediated through 5-HT1b receptors. Serotonin 51-60 5-hydroxytryptamine receptor 1B Cricetulus griseus 112-118 19605273-3 1978 In contrast, serotonin (10(-7) and 10(-5) M) significantly inhibited the release of LHRH from the MBH but not from the OVLT. Serotonin 13-22 gonadotropin releasing hormone 1 Rattus norvegicus 84-88 31865206-1 2020 Within the family of serotonin (5-HT) receptors, the 5-HT1A subtype is particularly interesting as it may be involved in various physiological processes or psychological disorders. Serotonin 21-30 5-hydroxytryptamine receptor 1A Homo sapiens 53-59 31969269-1 2020 BACKGROUND: The safety and efficacy of cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, was evaluated in 4 randomized, double-blind, placebo-controlled trials in patients with bipolar depression. Serotonin 112-121 5-hydroxytryptamine receptor 1A Homo sapiens 122-137 2138518-1 1990 Serotonin (10(-4) - 10(-7) M) augmented natural killer cell cytotoxicity (NKCC) of human CD16+/non-T lymphocytes in vitro against the NK-sensitive target cells K 562 erythroleukemic, Molt-4 lymphoma, Chang liver cells, and against EBV-transformed Daudi B-lymphoblastoid target cells by a mechanism of action involving a prostaglandin-and IL-1-independent accessory function of monocytes. Serotonin 0-9 interleukin 1 alpha Homo sapiens 338-342 32024542-2 2020 We have previously disclosed that paroxetine, a common selective serotonin reuptake inhibitor, ameliorates LPS-induced microglia activation. Serotonin 65-74 interferon regulatory factor 6 Homo sapiens 107-110 19605273-5 1978 The present results confirm in vivo data suggesting that the inhibitory effect of serotonin on the release of LHRH from median eminence involves a direct action on neurosecretory nerve-endings. Serotonin 82-91 gonadotropin releasing hormone 1 Rattus norvegicus 110-114 31980728-0 2021 Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Serotonin 79-83 adiponectin, C1Q and collagen domain containing Mus musculus 46-57 639364-6 1978 All doses of met5-enkephalin amide (150,200 and 600 microgram) and morphine (134 and 200 microgram) increased the brain levels of 5-hydroxyindoleacetic acid, whereas only the large doses modified the levels of noradrenaline and serotonin. Serotonin 228-237 proenkephalin Rattus norvegicus 18-28 2186420-4 1990 With 5-HT, evidence suggests that 5-HT receptors (in particular 5HT1A) are located on cholinergic projections and behavioral evidence suggests 5-HT modulation of memory function. Serotonin 5-9 5-hydroxytryptamine receptor 1A Homo sapiens 64-69 627836-2 1978 The lipid A-rich LPS of S. minnesota R595 and a lipid A preparation both potentiated platelet serotonin secretion in response to IgG aggregates or immune complexes up to 50-fold but had little effect in the absence of IgG. Serotonin 94-103 interferon regulatory factor 6 Homo sapiens 17-20 31980728-0 2021 Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Serotonin 79-83 adiponectin receptor 1 Mus musculus 58-65 31980728-4 2021 Here we show that adiponectin receptor 1 (AdipoR1) is expressed in the dorsal raphe nucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (5-HT) neurons. Serotonin 164-173 adiponectin receptor 1 Mus musculus 18-40 31980728-4 2021 Here we show that adiponectin receptor 1 (AdipoR1) is expressed in the dorsal raphe nucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (5-HT) neurons. Serotonin 164-173 adiponectin receptor 1 Mus musculus 42-49 31980728-4 2021 Here we show that adiponectin receptor 1 (AdipoR1) is expressed in the dorsal raphe nucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (5-HT) neurons. Serotonin 175-179 adiponectin receptor 1 Mus musculus 18-40 31980728-4 2021 Here we show that adiponectin receptor 1 (AdipoR1) is expressed in the dorsal raphe nucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (5-HT) neurons. Serotonin 175-179 adiponectin receptor 1 Mus musculus 42-49 31980728-5 2021 Selective deletion of AdipoR1 in 5-HT neurons induced anhedonia in male mice, as indicated by reduced female urine sniffing time and saccharin preference, and behavioral despair in female mice and enhanced stress-induced decrease in sucrose preference in both sexes. Serotonin 33-37 adiponectin receptor 1 Mus musculus 22-29 31980728-10 2021 Our results indicate that adiponectin acts on 5-HT neurons through AdipoR1 receptors to regulate depression-related behaviors in a sex-dependent manner. Serotonin 46-50 adiponectin, C1Q and collagen domain containing Mus musculus 26-37 2186420-4 1990 With 5-HT, evidence suggests that 5-HT receptors (in particular 5HT1A) are located on cholinergic projections and behavioral evidence suggests 5-HT modulation of memory function. Serotonin 34-38 5-hydroxytryptamine receptor 1A Homo sapiens 64-69 31980728-10 2021 Our results indicate that adiponectin acts on 5-HT neurons through AdipoR1 receptors to regulate depression-related behaviors in a sex-dependent manner. Serotonin 46-50 adiponectin receptor 1 Mus musculus 67-74 290743-7 1978 Patients with hepatic coma had an elevated concentration of 5-HIAA in the lumbar CSF which may reflect the increase in this compound and in serotonin reported by Jellinger and Riederer (1977). Serotonin 140-149 colony stimulating factor 2 Homo sapiens 81-84 2186420-4 1990 With 5-HT, evidence suggests that 5-HT receptors (in particular 5HT1A) are located on cholinergic projections and behavioral evidence suggests 5-HT modulation of memory function. Serotonin 34-38 5-hydroxytryptamine receptor 1A Homo sapiens 64-69 1706890-3 1990 In the light of the strong depolarisation effect and of the presence of specific binding sites for serotonin, the results are discussed as suggesting that MBP enhances the REMS triggering mechanisms. Serotonin 99-108 myelin basic protein Felis catus 155-158 144573-8 1977 The activities of sarcolemmal adenosinetriphosphatase and acetylcholinesterase were inhibited in vitro by imipramine and serotonin. Serotonin 121-130 acetylcholinesterase Rattus norvegicus 58-78 32399392-0 2020 Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension. Serotonin 91-100 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 52-57 32399392-2 2020 TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chronic hypoxia mice. Serotonin 21-30 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 0-5 32399392-2 2020 TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chronic hypoxia mice. Serotonin 33-37 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 0-5 32399392-2 2020 TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chronic hypoxia mice. Serotonin 119-123 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 0-5 32399392-5 2020 Here, we examined the role of EET-dependent TRPV4 activation in the 5-HT-mediated PA contraction. Serotonin 68-72 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 44-49 32399392-6 2020 In PAs of normoxic mice, inhibition of TRPV4 with a specific inhibitor HC-067047 caused a decrease in the sensitivity of 5-HT-induced PA contraction without affecting the maximal contractile response. Serotonin 121-125 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 39-44 2269460-1 1990 Fluorimetric methods were used to determine adrenaline, dopamine, noradrenaline, serotonin and tryptamine in the pia mater of the brain and spinal cord of various vertebrates (fishes, birds, mammals) and of man. Serotonin 81-90 RPTOR independent companion of MTOR complex 2 Homo sapiens 113-116 32399392-8 2020 In contrast, inhibition of CYP epoxygenase or TRPV4 both attenuated the 5-HT-elicited maximal contraction to a comparable level in PAs of chronic hypoxic mice. Serotonin 72-76 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 46-51 32399392-9 2020 Moreover, the inhibitory effect of MS-PPOH on the 5-HT-induced contraction was obliterated in PAs of chronic hypoxic trpv4-/- mice. Serotonin 50-54 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 117-122 32399392-10 2020 These results suggest that TRPV4 contributes to the enhanced 5-HT-induced vasoconstriction in chronic hypoxic PAs, in part via the CYP-EET-TRPV4 pathway. Serotonin 61-65 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 27-32 32399392-10 2020 These results suggest that TRPV4 contributes to the enhanced 5-HT-induced vasoconstriction in chronic hypoxic PAs, in part via the CYP-EET-TRPV4 pathway. Serotonin 61-65 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 139-144 31998441-7 2020 Increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and stronger hepatic tissue pathology were detected, suggesting that serotonin could mediate Con A-induced liver damage. Serotonin 163-172 glutamic pyruvic transaminase, soluble Mus musculus 26-50 31998441-7 2020 Increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and stronger hepatic tissue pathology were detected, suggesting that serotonin could mediate Con A-induced liver damage. Serotonin 163-172 glutamic pyruvic transaminase, soluble Mus musculus 52-55 31998441-7 2020 Increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and stronger hepatic tissue pathology were detected, suggesting that serotonin could mediate Con A-induced liver damage. Serotonin 163-172 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 61-87 1243080-0 1975 Inhibition of cholinesterase by 5-hydroxytryptamine. Serotonin 32-51 butyrylcholinesterase Homo sapiens 14-28 814560-9 1975 The data are interpreted in the light of the particular endocrine state existing through pregnancy, attributing to serotonin a role in the functioning of PIF-prolactin system. Serotonin 115-124 PIF1 5'-to-3' DNA helicase Homo sapiens 154-157 31998441-7 2020 Increased serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and stronger hepatic tissue pathology were detected, suggesting that serotonin could mediate Con A-induced liver damage. Serotonin 163-172 solute carrier family 17 (anion/sugar transporter), member 5 Mus musculus 89-92 1369711-3 1990 Serotonin is taken up and destroyed by the endothelial cells; these cells also release endothelium-derived relaxing factor (EDRF) when exposed to the monoamine. Serotonin 0-9 alpha hemoglobin stabilizing protein Homo sapiens 87-122 31998441-8 2020 Serotonin significantly facilitated the release of serum and intrahepatic inflammatory cytokines, including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17A (IL-17A), interferon-gamma (IFN-gamma), and tumor necrosis-alpha (TNF-alpha), after the administration of Con A. Serotonin 0-9 interleukin 2 Mus musculus 108-121 31998441-8 2020 Serotonin significantly facilitated the release of serum and intrahepatic inflammatory cytokines, including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17A (IL-17A), interferon-gamma (IFN-gamma), and tumor necrosis-alpha (TNF-alpha), after the administration of Con A. Serotonin 0-9 interleukin 2 Mus musculus 123-127 31819176-8 2020 CONCLUSIONS: We showed that serotonin, through 5-HTR2A/C, interferes with breast cancer cells proliferation and metabolism by triggering two distinct signalling pathways: Jak1/STAT3 that boosts glycolysis through upregulation of PKM2, and adenylyl cyclase/PKA that enhances mitochondrial biogenesis. Serotonin 28-37 pyruvate kinase M1/2 Homo sapiens 229-233 4419680-0 1974 Evidence for a peripheral effect of fusaric acid, a dopamine beta-hydroxylase inhibitor, on serotonin metabolism. Serotonin 92-101 dopamine beta-hydroxylase Homo sapiens 52-77 1369711-3 1990 Serotonin is taken up and destroyed by the endothelial cells; these cells also release endothelium-derived relaxing factor (EDRF) when exposed to the monoamine. Serotonin 0-9 alpha hemoglobin stabilizing protein Homo sapiens 124-128 1369711-4 1990 The release of EDRF evoked by serotonin is not blocked by 5-HT2-serotonergic antagonists and involves a pertussis toxin-sensitive G-protein. Serotonin 30-39 alpha hemoglobin stabilizing protein Homo sapiens 15-19 32342809-3 2020 MAO-A is a flavoenzyme, which binds to the outer mitochondrial membrane and catalyzes the oxidative transformations of neurotransmitters like serotonin, norepinephrine, and dopamine. Serotonin 142-151 monoamine oxidase A Homo sapiens 0-5 1369711-7 1990 The same is true for contractions evoked by aggregating platelets, which release enough serotonin to activate receptors on both the endothelial cells (release of EDRF) and on vascular smooth muscle (contraction). Serotonin 88-97 alpha hemoglobin stabilizing protein Homo sapiens 162-166 1697619-10 1990 The 5HT/5HIAA ratio was significantly increased by IFN-gamma, either when given alone or when given in combination with ISO. Serotonin 4-7 interferon gamma Rattus norvegicus 51-60 32538722-7 2020 Previous studies have found that TRP supplementation aggravates fatty liver degeneration by producing 5-HT which activates mTOR signaling pathway in mice fed a high fat and high fructose diet. Serotonin 102-106 mechanistic target of rapamycin kinase Mus musculus 123-127 13787921-0 1960 Effect of certain compounds on in vitro degradation of serotonin by ceruloplasmin. Serotonin 55-64 ceruloplasmin Homo sapiens 68-81 1697619-11 1990 The results suggest that IFN-gamma enhances melatonin production in the pineal gland by suppressing the oxidative deamination of 5HT to 5HIAA and shunting the biosynthetic pathway toward melatonin production. Serotonin 129-132 interferon gamma Rattus norvegicus 25-34 2141111-6 1990 The changes in potential produced by low concentrations of serotonin and by these agonists were blocked by the 5-HT1A receptor antagonists spiperone and spiroxatrine. Serotonin 59-68 5-hydroxytryptamine receptor 1A Homo sapiens 111-126 33737066-2 2021 Because of the modulatory role of brain-derived neurotrophic factor (BDNF) on the serotonin system and the effects of METH, we included both BDNF heterozygous (HET) mice and wildtype (WT) controls. Serotonin 82-91 brain derived neurotrophic factor Mus musculus 69-73 31706600-4 2020 Monoamine oxidase A (MAOA) aids in serotonin uptake and is often implicated in behavioral and emotional disorders, including ADHD. Serotonin 35-44 monoamine oxidase A Homo sapiens 21-25 2147516-1 1990 Previously, the 5-hydroxytryptamine (5-HT)1A receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone and the 5-HT3 receptor antagonist ICS 205-930 have been shown to exert anxiolytic-like effects in several animal models. Serotonin 16-35 5-hydroxytryptamine receptor 1A Homo sapiens 37-53 31920532-8 2019 However, genetic brain 5-HT deficiency blocks HFD-induced reductions in forced swim immobility and prevents HFD-induced increases in hippocampal GSK3beta phosphorylation despite having no significant effects on HFD-induced changes in body weight or anxiety-like behavior. Serotonin 23-27 glycogen synthase kinase 3 beta Mus musculus 145-153 33836219-4 2021 In a first series of experiments, we found that acute administration of the serotonin reuptake inhibitors citalopram, fluoxetine, or duloxetine all reduced lever pressing reinforced on an FR1 schedule with presentation of a cue that had been previously paired with delivery of food. Serotonin 76-85 aldo-keto reductase family 1, member B8 Mus musculus 188-191 34045888-10 2021 Conclusion: Here, we provided evidence that the human breast cancer cell (MCF-7, Bcap-37) and human breast epithelial cell (MCF-10A) could synthesize intrinsic serotonin and melatonin, and serotonin expression was higher in the breast cancer tissue compared with PCT. Serotonin 160-169 prohibitin 2 Homo sapiens 81-88 34045888-10 2021 Conclusion: Here, we provided evidence that the human breast cancer cell (MCF-7, Bcap-37) and human breast epithelial cell (MCF-10A) could synthesize intrinsic serotonin and melatonin, and serotonin expression was higher in the breast cancer tissue compared with PCT. Serotonin 189-198 prohibitin 2 Homo sapiens 81-88 33973477-5 2021 The most studied drug categories were anticonvulsants and selective serotonin reuptake inhibitors associated with human leukocyte antigen and cytochrome P450 genes (HLA-A, HLA-B, CYP2C9, CYP2D6, CYP2C19), classified as critically low quality/low quality. Serotonin 68-77 major histocompatibility complex, class I, B Homo sapiens 172-177 34006587-9 2021 Shox2 INs were differentially modulated by serotonin (5-HT) in a concentration-dependent manner in uninjured conditions but following SCI, 5-HT predominantly depolarized Shox2 INs. Serotonin 43-52 short stature homeobox 2 Mus musculus 0-5 34006587-9 2021 Shox2 INs were differentially modulated by serotonin (5-HT) in a concentration-dependent manner in uninjured conditions but following SCI, 5-HT predominantly depolarized Shox2 INs. Serotonin 54-58 short stature homeobox 2 Mus musculus 0-5 34006587-9 2021 Shox2 INs were differentially modulated by serotonin (5-HT) in a concentration-dependent manner in uninjured conditions but following SCI, 5-HT predominantly depolarized Shox2 INs. Serotonin 139-143 short stature homeobox 2 Mus musculus 0-5 34006587-9 2021 Shox2 INs were differentially modulated by serotonin (5-HT) in a concentration-dependent manner in uninjured conditions but following SCI, 5-HT predominantly depolarized Shox2 INs. Serotonin 139-143 short stature homeobox 2 Mus musculus 170-175 34006587-11 2021 Overall, SCI alters sensory afferent input pathways to Shox2 INs and 5-HT modulation of Shox2 INs to enhance excitatory responses. Serotonin 69-73 short stature homeobox 2 Mus musculus 88-93 31692380-1 2019 Aims: Circadian rhythm genes including Period 3 (Per3) are associated with major depressive disorder (MDD) and have an effect on the patient"s response to selective serotonin reuptake inhibitor (SSRI) antidepressants. Serotonin 165-174 period circadian regulator 3 Homo sapiens 39-47 31692380-1 2019 Aims: Circadian rhythm genes including Period 3 (Per3) are associated with major depressive disorder (MDD) and have an effect on the patient"s response to selective serotonin reuptake inhibitor (SSRI) antidepressants. Serotonin 165-174 period circadian regulator 3 Homo sapiens 49-53 31771567-11 2019 Intraperitoneal injection of the cathepsin L inhibitor CLIK195 similarly reduced body weight gain and white adipose tissue (WAT) adipogenesis, while elevating brain serotonin level and WAT lipolysis and fatty acid beta-oxidation. Serotonin 165-174 cathepsin L Mus musculus 33-44 31771567-12 2019 These effects of inhibiting cathepsin L were abolished by intracranial injection of p-chlorophenylalanine, inhibitor of a rate-limiting enzyme for serotonin synthesis. Serotonin 147-156 cathepsin L Mus musculus 28-39 31771567-13 2019 CONCLUSION: This study reveals a previously undescribed molecular mechanism by which peripheral CPL-1/cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin signaling. Serotonin 191-200 cathepsin L Mus musculus 102-113 33776821-1 2021 Introduction: The aim of this study was to determine the mRNA expression profile of dopamine D1, D2, D3, D4 and serotonin 5-HT1A, 5-HT2A, and 5-HT3A receptors in peripheral blood mononuclear cells (PBMCs) in schizophrenia and the in vitro effect of antipsychotics on the expression of these receptors in PBMCs of healthy subjects. Serotonin 112-121 5-hydroxytryptamine receptor 1A Homo sapiens 122-128 30716416-2 2019 The best-characterized of these interplays occurs between: a) low-activity alleles of the gene encoding monoamine oxidase A (MAOA), the main serotonin-degrading enzyme; and b) child maltreatment. Serotonin 141-150 monoamine oxidase A Homo sapiens 104-123 30716416-2 2019 The best-characterized of these interplays occurs between: a) low-activity alleles of the gene encoding monoamine oxidase A (MAOA), the main serotonin-degrading enzyme; and b) child maltreatment. Serotonin 141-150 monoamine oxidase A Homo sapiens 125-129 33980291-1 2021 The neurotransmitter serotonin, involved in the regulation of pain and emotion, is critically regulated by the 5-HT1A autoreceptor and the serotonin transporter (5-HTT). Serotonin 21-30 5-hydroxytryptamine receptor 1A Homo sapiens 111-117 33980291-4 2021 Interactions between serotonin-relevant genes were found in affective characteristics, with genetically inferred high serotonergic signalling (5-HT1A CC/5-HTThigh genotypes) being more favourable across groups. Serotonin 21-30 5-hydroxytryptamine receptor 1A Homo sapiens 143-149 33776821-4 2021 The expression of mRNA for dopamine D1-4 and serotonin 5-HT1A-3A receptors was measured using quantitative RT-PCR in peripheral blood mononuclear cells. Serotonin 45-54 5-hydroxytryptamine receptor 1A Homo sapiens 55-61 31754354-5 2019 To better understand the relationship between serotonin and BTIC we expanded our analysis to include monoamine oxidase-A (MAO-A), an enzyme that metabolizes serotonin. Serotonin 157-166 monoamine oxidase A Homo sapiens 101-120 31754354-5 2019 To better understand the relationship between serotonin and BTIC we expanded our analysis to include monoamine oxidase-A (MAO-A), an enzyme that metabolizes serotonin. Serotonin 157-166 monoamine oxidase A Homo sapiens 122-127 25497297-7 2015 RESULTS: Results suggest that MAOA promoter hypermethylation is associated with ASPD and may contribute to downregulation of MAOA gene expression, as indicated by functional assays in vitro, and regression analysis with whole-blood serotonin levels in offenders with ASPD. Serotonin 232-241 monoamine oxidase A Homo sapiens 30-34 31831958-2 2019 Molecular dynamics simulation (MDS) and docking analysis of biogenic monoamines with ceruloplasmin explain the role of Asp1025, Glu935, Glu272, Glu232 and Glu230 together with the binding site water molecules (referred as conserved water molecules) in the stabilization of neurotransmitter (Serotonin, Norepinephrine and Epinephrine) molecules within the binding cavity of hCP. Serotonin 291-300 ceruloplasmin Homo sapiens 85-98 33543768-3 2021 EXPERIMENTAL APPROACH: We performed immunohistochemistry and anatomical experiments to determine whether raphe serotonin cells expressing Fos were directly targeted by the rostral cuneiform nucleus. Serotonin 111-120 FBJ osteosarcoma oncogene Mus musculus 138-141 33464458-2 2021 Although the underlying mechanism remains unknown, the type-1A serotonin receptor (5-HT1A) and cannabinoids type-1 (CB1) and type-2 (CB2) receptors seem to play a central role in mediating the beneficial effects on emotional responses. Serotonin 63-72 cannabinoid receptor 2 Rattus norvegicus 133-136 33567384-0 2021 Associations and interactions of the serotonin receptor genes 5-HT1A, 5-HT2A, and childhood trauma with alexithymia in two independent general-population samples. Serotonin 37-46 5-hydroxytryptamine receptor 1A Homo sapiens 62-68 33567384-2 2021 Specifically, genetic polymorphisms of the serotonin receptors 5-HT1A and 5-HT2A were found to be associated with alexithymia. Serotonin 43-52 5-hydroxytryptamine receptor 1A Homo sapiens 63-69 19614755-10 2009 The cat-2 and tph-1 mutant animals have defects in the synthetic enzymes for dopamine and serotonin, respectively. Serotonin 90-99 BH4_AAA_HYDROXYL_2 domain-containing protein;Tyrosine 3-hydroxylase;Tyrosine 3-monooxygenase Caenorhabditis elegans 4-9 30653836-4 2019 Loss of COUP-TFI in the cortical mouse primordium results in altered area organization and serotonin distribution, abnormal coordination of voluntary movements and learning and memory deficits. Serotonin 91-100 nuclear receptor subfamily 2, group F, member 1 Mus musculus 8-16 34923109-2 2022 Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Serotonin 99-108 monoamine oxidase A Homo sapiens 13-32 33723417-4 2021 Here we report that the p11/SMARCA3 complex represses Neurensin-2 transcription in hippocampal parvalbumin-expressing interneurons after chronic treatment with Selective Serotonin Reuptake Inhibitors (SSRI). Serotonin 170-179 endonuclease, poly(U) specific Homo sapiens 24-27 33723417-4 2021 Here we report that the p11/SMARCA3 complex represses Neurensin-2 transcription in hippocampal parvalbumin-expressing interneurons after chronic treatment with Selective Serotonin Reuptake Inhibitors (SSRI). Serotonin 170-179 helicase like transcription factor Homo sapiens 28-35 31555094-5 2019 In this study, we analyzed the protein expression of the BDNF isoforms, i.e., pro- and mature-BDNF, and their respective receptors p75 and TrkB, in the HC of mice chronically treated with para-chloro-phenyl-alanine (PCPA), an inhibitor of serotonin synthesis. Serotonin 239-248 brain derived neurotrophic factor Mus musculus 57-61 34923109-2 2022 Among these, Monoamine oxidase A (MAOA) catalyzes the degradation of dopamine, norepinephrine, and serotonin into their inactive metabolites. Serotonin 99-108 monoamine oxidase A Homo sapiens 34-38 33112414-0 2021 Selective serotonin reuptake inhibitor attenuates the hyperresponsivenss of TLR2+ and TLR4+ Th17/Tc17-like cells in multiple sclerosis patients with major depression. Serotonin 10-19 toll like receptor 4 Homo sapiens 86-90 34839189-0 2022 Impaired prepulse inhibition in mice with IRSp53 deletion in modulatory neurotransmitter neurons including dopamine, acetylcholine, oxytocin, and serotonin. Serotonin 146-155 brain-specific angiogenesis inhibitor 1-associated protein 2 Mus musculus 42-48 33668396-0 2021 Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT1A Serotonin Receptor Antagonists. Serotonin 107-116 5-hydroxytryptamine receptor 1A Homo sapiens 100-106 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Serotonin 96-105 monoamine oxidase A Homo sapiens 4-23 30456877-1 2019 The monoamine oxidase A (MAOA) enzyme metabolizes monoamine neurotransmitters such as dopamine, serotonin and norepinephrine, and its genetic polymorphism (rs1137070) influences its activity level and is associated with smoking behaviors. Serotonin 96-105 monoamine oxidase A Homo sapiens 25-29 34973493-4 2022 Recently, administering 5HT to a Piezo1 mutant mouse strain with hyposerotonemia, intestinal dysmotility, and a doubling of femoral trabecular bone mass at 2 months of age, was reported to return the animals" intestinal motility and bone mass to normal. Serotonin 24-27 piezo-type mechanosensitive ion channel component 1 Mus musculus 33-39 31460097-1 2019 Mapping different structural forms of serotonin subtypes 5-HT1A-5-HT7 using a selective-specific ligand with good pharmacokinetics and brain permeability can open avenues for personalized medication in depressed population. Serotonin 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 57-63 33466782-3 2021 In the present work, the level of 5-HT in serum and the number of enteroendocrine cells (EECs) as well as the expression of the 5-HT rate-limiting enzyme tryptophan hydroxylase 1 (TPH1) in colonic biopsies and urine 5-hydroxyindoeoacetic acid (5-HIAA) were determined in 36 LC patients that were treated with budesonide and 32 healthy controls. Serotonin 128-132 tryptophan hydroxylase 1 Homo sapiens 154-178 33466782-3 2021 In the present work, the level of 5-HT in serum and the number of enteroendocrine cells (EECs) as well as the expression of the 5-HT rate-limiting enzyme tryptophan hydroxylase 1 (TPH1) in colonic biopsies and urine 5-hydroxyindoeoacetic acid (5-HIAA) were determined in 36 LC patients that were treated with budesonide and 32 healthy controls. Serotonin 128-132 tryptophan hydroxylase 1 Homo sapiens 180-184 33466782-5 2021 The levels of 5-HT and 5-HIAA and the number of EECs were higher in LC patients than in the controls, and positive correlations were observed between the 5-HT and 5-HIAA levels, 5-HT and EEC number, TPH1 mRNA and EEC number, as well as the severity of disease symptoms and 5-HIAA. Serotonin 154-158 tryptophan hydroxylase 1 Homo sapiens 199-203 33466782-5 2021 The levels of 5-HT and 5-HIAA and the number of EECs were higher in LC patients than in the controls, and positive correlations were observed between the 5-HT and 5-HIAA levels, 5-HT and EEC number, TPH1 mRNA and EEC number, as well as the severity of disease symptoms and 5-HIAA. Serotonin 154-158 tryptophan hydroxylase 1 Homo sapiens 199-203 33414449-6 2021 We then explore genetic or pharmacologic modulation of PST activities in mice: variations of PST activities were associated with marked variations of blood serotonin, demonstrating the influence of the sulfation pathway on serotonemia. Serotonin 156-165 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 93-96 33087457-4 2021 RNA sequencing (RNA-Seq) of islets suggested that Sirt3 deficiency over-activated 5-hydroxytryptamine (5-HT) synthesis as evidenced by up-regulation of tryptophan hydroxylase 1 (TPH1). Serotonin 82-101 sirtuin 3 Mus musculus 50-55 33087457-4 2021 RNA sequencing (RNA-Seq) of islets suggested that Sirt3 deficiency over-activated 5-hydroxytryptamine (5-HT) synthesis as evidenced by up-regulation of tryptophan hydroxylase 1 (TPH1). Serotonin 103-107 sirtuin 3 Mus musculus 50-55 33087457-5 2021 5-HT concentration was increased in both islets and serum of Sirt3 f/f;Cre/+ mice. Serotonin 0-4 sirtuin 3 Mus musculus 61-66 33087457-8 2021 These data suggested that under HFD feeding, SIRT3 deficiency in beta cells not only regulates insulin secretion but also modulates hepatic lipid metabolism via the release of 5-HT. Serotonin 176-180 sirtuin 3 Mus musculus 45-50 33380568-12 2021 Conclusions: These observations indicate that systemically administered NTSR1 agonist produces antinociception through the NTSR1 in the RVM, activating descending serotonergic projection to release 5-HT into the spinal dorsal horn. Serotonin 198-202 neurotensin receptor 1 Rattus norvegicus 72-77 33380568-12 2021 Conclusions: These observations indicate that systemically administered NTSR1 agonist produces antinociception through the NTSR1 in the RVM, activating descending serotonergic projection to release 5-HT into the spinal dorsal horn. Serotonin 198-202 neurotensin receptor 1 Rattus norvegicus 123-128 32989626-0 2021 Memory impairment of chewing-side preference mice is associated with 5-HT-BDNF signal pathway. Serotonin 69-73 brain derived neurotrophic factor Mus musculus 74-78 32989626-8 2021 These findings suggest that CSP results in memory impairment, which is associated with the 5-HT-BDNF signaling pathway. Serotonin 91-95 brain derived neurotrophic factor Mus musculus 96-100 33785135-2 2021 The effects of 5-hydroxytryptamine (5-HT) on layer V pyramidal cells primarily reflect a range of excitatory influences through 5-HT2A receptors and inhibitory influences through non-5-HT2A receptors, including 5-HT1A receptors. Serotonin 15-34 5-hydroxytryptamine receptor 1A Homo sapiens 211-217 33785135-2 2021 The effects of 5-hydroxytryptamine (5-HT) on layer V pyramidal cells primarily reflect a range of excitatory influences through 5-HT2A receptors and inhibitory influences through non-5-HT2A receptors, including 5-HT1A receptors. Serotonin 36-40 5-hydroxytryptamine receptor 1A Homo sapiens 211-217 33785138-5 2021 The effect of 5-HT on STN neuronal activity involves several 5-HT receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT2C and 5-HT4 receptors, which have garnered the highest attention on this topic. Serotonin 14-18 5-hydroxytryptamine receptor 1A Homo sapiens 95-101 33785138-5 2021 The effect of 5-HT on STN neuronal activity involves several 5-HT receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT2C and 5-HT4 receptors, which have garnered the highest attention on this topic. Serotonin 61-65 5-hydroxytryptamine receptor 1A Homo sapiens 95-101 33215629-8 2020 The level of serotonin synthesis enzyme TPH-1 was higher in early gestation female placentas and at term serotonin concentration was 3-fold higher in the umbilical vein than in the umbilical artery. Serotonin 13-22 tryptophan hydroxylase 1 Homo sapiens 40-45 33172979-14 2020 Additionally, we also find that FGF13 is involved in 5-HT-induced scratching behavior and hapten 1-fluoro-2,4-dinitrobenzene (DNFB)-induced chronic itch. Serotonin 53-57 fibroblast growth factor 13 Mus musculus 32-37 32958730-7 2020 GLR-1 further positively affected the function of SER-7-mediated serotonin signaling and antagonized the function of DAT-1-mediated dopamine signaling in the regulation of innate immune response to fungal infection. Serotonin 65-74 Glutamate receptor 1 Caenorhabditis elegans 0-5 33155799-9 2020 Activation of Sirt1 by resveratrol or inhibition of MAO-A by moclobemide administration could restore brain NA and 5-HT levels and attenuate the depressive-like behavior of A53T mice. Serotonin 115-119 sirtuin 1 Mus musculus 14-19 33294225-5 2020 Genetic analysis included the SLC6A4 and SLC29A4 genes encoding synaptic serotonin reuptake proteins. Serotonin 73-82 solute carrier family 29 member 4 Homo sapiens 41-48 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Serotonin 175-184 monoamine oxidase A Homo sapiens 20-25 33262691-8 2020 Given the multifaceted other players than MAOA that are involved in the regulation of serotonin levels, potential compensatory effects are surveyed, which may underlie the autism heterogeneity. Serotonin 86-95 monoamine oxidase A Homo sapiens 42-46 33168874-1 2020 5-HT inhibits cardiac sympathetic neurotransmission in normoglycaemic rats, via 5-HT1B, 5-HT1D and 5-HT5A receptor activation. Serotonin 0-4 5-hydroxytryptamine receptor 1D Rattus norvegicus 88-94 33055197-10 2020 Rln3 neurons project to the limbic cortex, septum, hippocampus, and hypothalamus, in a way that resembles the ascending brain systems expressing dopamine, serotonin, and norepinephrine. Serotonin 155-164 relaxin 3 Homo sapiens 0-4 33149591-7 2020 The serotonin 6 and 7 receptors are associated with schizophrenia via modulating cyclic adenosine monophosphate, regulation of Fyn kinase and induction of structural plasticity. Serotonin 4-13 FYN proto-oncogene, Src family tyrosine kinase Homo sapiens 127-130 33066466-4 2020 Here we examined the role of the high-affinity, low-capacity serotonin transporter (SERT), and the plasma membrane monoamine transporter (PMAT), a low-affinity, high-capacity transporter for serotonin, as mechanisms contributing to ketamine"s ability to increase extracellular serotonin and produce antidepressant-like effects. Serotonin 191-200 solute carrier family 29 (nucleoside transporters), member 4 Mus musculus 138-142 32416114-0 2020 The behavioral and neurochemical characterization of a Drosophila dysbindin mutant supports the contribution of serotonin to schizophrenia negative symptoms. Serotonin 112-121 Dysbindin Drosophila melanogaster 66-75 32311818-0 2020 Serotonin homeostasis in the materno-fetal interface at term: role of transporters (SERT/SLC6A4 and OCT3/SLC22A3) and monoamine oxidase A (MAO-A) in uptake and degradation of serotonin by human and rat term placenta. Serotonin 0-9 monoamine oxidase A Homo sapiens 118-137 32418902-7 2020 Furthermore, 5-HT- and DSS-induced changes were accompanied by marked upregulations of increased inflammatory signaling pathways linked to NF-kappaB, AP-1, and STAT3 transcription factors, and to GATA, a cell fate-directing signaling. Serotonin 13-17 glutaminyl-tRNA amidotransferase subunit QRSL1 Homo sapiens 196-200 32801896-1 2020 Purpose: Neuroendocrine tumors (NETs) associated with carcinoid syndrome (CS) overproduce serotonin, mediated by tryptophan hydroxylase-1 (TPH1). Serotonin 90-99 tryptophan hydroxylase 1 Homo sapiens 113-137 32801896-1 2020 Purpose: Neuroendocrine tumors (NETs) associated with carcinoid syndrome (CS) overproduce serotonin, mediated by tryptophan hydroxylase-1 (TPH1). Serotonin 90-99 tryptophan hydroxylase 1 Homo sapiens 139-143 32685863-2 2020 Competitive radioligand binding assays demonstrate that it has a high affinity at human serotonin receptors 5-HT1A, 5-HT2A, and 5-HT2B, though it does not bind at the 5-HT3 receptor, where activity was previously predicted. Serotonin 88-97 5-hydroxytryptamine receptor 1A Homo sapiens 108-114 32416387-0 2020 Brain-derived neurotrophic factor in 5-HT neurons regulates susceptibility to depression-related behaviors induced by subchronic unpredictable stress. Serotonin 37-41 brain derived neurotrophic factor Mus musculus 0-33 32416387-7 2020 Bdnf was highly expressed in 5- Hydroxytryptamine (5-HT) neurons from the DRN. Serotonin 29-49 brain derived neurotrophic factor Mus musculus 0-4 32416387-7 2020 Bdnf was highly expressed in 5- Hydroxytryptamine (5-HT) neurons from the DRN. Serotonin 51-55 brain derived neurotrophic factor Mus musculus 0-4 32416387-8 2020 Selective deletion of Bdnf in 5-HT neurons alone could not induce anhedonia and behavioral despair in male or female mice, as indicated by the unchanged female urine sniffing time and preference for sucrose/saccharin. Serotonin 30-34 brain derived neurotrophic factor Mus musculus 22-26 32416387-12 2020 Our results indicate that BDNF might act on 5-HT neurons to regulate depression-related behaviors and stress vulnerability in a sex-dependent manner. Serotonin 44-48 brain derived neurotrophic factor Mus musculus 26-30 32484164-0 2020 Ginkgolide-Platinum(II) Complex GPt(II) Exhibits Therapeutic Effect on Depression in Mice via Upregulation of DA and 5-HT Neurotransmitters. Serotonin 117-121 glutamic pyruvic transaminase, soluble Mus musculus 32-35 32484164-8 2020 Treatment of mice with GPt(II) significantly elevated dopamine, BDNF, and serotonin levels in hippocampus tissues. Serotonin 74-83 glutamic pyruvic transaminase, soluble Mus musculus 23-26 32390801-4 2020 Methods: A set of 29 SNPs of genes of serotonin receptors HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B, and HTR6 was studied in a population of 449 Caucasians (226 females and 223 males) with verified clinical diagnosis of schizophrenia (according to ICD-10: F20). Serotonin 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 58-63 32390801-4 2020 Methods: A set of 29 SNPs of genes of serotonin receptors HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR3B, and HTR6 was studied in a population of 449 Caucasians (226 females and 223 males) with verified clinical diagnosis of schizophrenia (according to ICD-10: F20). Serotonin 38-47 5-hydroxytryptamine receptor 3B Homo sapiens 93-98 32028177-10 2020 A lack of information on important components for serotonin biosynthesis and vesicle endocytosis (i.e., tryptophan hydroxylase and vesicular monoamine transporter) in Crustacea was also brought to light. Serotonin 50-59 Tryptophan hydroxylase Drosophila melanogaster 104-126 31863855-0 2020 The role of 5-HT4 serotonin receptors in the CA1 hippocampal region on memory acquisition impairment induced by total (TSD) and REM sleep deprivation (RSD). Serotonin 18-27 carbonic anhydrase 1 Rattus norvegicus 45-48 32170814-1 2020 Equilibrative nucleoside transporter 4 (ENT4), encoded by SLC29A4, mediates the flux of both 5-hydroxytryptamine (5-HT) and adenosine across cell membranes. Serotonin 93-112 solute carrier family 29 (nucleoside transporters), member 4 Mus musculus 58-65 32046135-7 2020 Using ex vivo perforated patch-clamp recordings of lumbar MNs coupled with pharmacology, we demonstrated that 5-HT strongly hyperpolarizes the EGABAAR by interacting with KCC2. Serotonin 110-114 solute carrier family 12, member 5 Mus musculus 171-175 32017483-0 2020 Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands. Serotonin 0-9 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 55-61 32017483-4 2020 We hypothesized that 5-HT activates AhR indirectly by interfering with metabolic clearance of AhR ligands by cytochrome P450 1A1 (CYP1A1). Serotonin 21-25 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 109-128 32017483-4 2020 We hypothesized that 5-HT activates AhR indirectly by interfering with metabolic clearance of AhR ligands by cytochrome P450 1A1 (CYP1A1). Serotonin 21-25 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 130-136 32017483-5 2020 METHODS: Inhibition of CYP1A1 activity by 5-HT was assessed in the human intestinal epithelial cell line Caco-2 and recombinant CYP1A1 microsomes using both luciferase and LC-MS/MS. Serotonin 42-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 23-29 32017483-5 2020 METHODS: Inhibition of CYP1A1 activity by 5-HT was assessed in the human intestinal epithelial cell line Caco-2 and recombinant CYP1A1 microsomes using both luciferase and LC-MS/MS. Serotonin 42-46 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 32017483-6 2020 Degradation of 5-HT by recombinant CYP1A1 was measured by LC-MS/MS. Serotonin 15-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-41 32017483-9 2020 RESULTS: We show that 5-HT inhibits metabolism of both the pro-luciferin CYP1A1 substrate Luc-CEE as well as the high affinity AhR ligand 6-formylindolo[3,2-b] carbazole (FICZ). Serotonin 22-26 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 73-79 32017483-10 2020 Recombinant CYP1A1 assays revealed that 5-HT is metabolized by CYP1A1 in an NADPH dependent manner. Serotonin 40-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 12-18 32017483-10 2020 Recombinant CYP1A1 assays revealed that 5-HT is metabolized by CYP1A1 in an NADPH dependent manner. Serotonin 40-44 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 63-69 29847220-8 2020 Furthermore, increase in the hippocampus protein expression of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB, with increased serotonin level were also observed in the treated animals. Serotonin 191-200 brain derived neurotrophic factor Mus musculus 63-96 29847220-8 2020 Furthermore, increase in the hippocampus protein expression of brain-derived neurotrophic factor (BDNF), cAMP response element binding protein (CREB), and phosphorylated CREB, with increased serotonin level were also observed in the treated animals. Serotonin 191-200 brain derived neurotrophic factor Mus musculus 98-102 31905199-4 2020 Here, by performing single-cell transcriptomics, we found that amyloid toxicity-induced interleukin-4 (IL4) promotes NSC proliferation and neurogenesis by suppressing the tryptophan metabolism and reducing the production of serotonin. Serotonin 224-233 interleukin 4 Danio rerio 88-101 31905199-4 2020 Here, by performing single-cell transcriptomics, we found that amyloid toxicity-induced interleukin-4 (IL4) promotes NSC proliferation and neurogenesis by suppressing the tryptophan metabolism and reducing the production of serotonin. Serotonin 224-233 interleukin 4 Danio rerio 103-106 31706600-4 2020 Monoamine oxidase A (MAOA) aids in serotonin uptake and is often implicated in behavioral and emotional disorders, including ADHD. Serotonin 35-44 monoamine oxidase A Homo sapiens 0-19 32144993-3 2020 Here, we showed that specific activation of 5-hydroxytryptamine (5-HT) type 2A receptors by systemic administration of TCB-2 [(4-bromo-3,6-dimethoxybenzocyclobuten-1-yl) methylamine hydrobromide] improved the function of potassium chloride cotransporter 2 (KCC2), resulting in reduction in neuropathic pain after chronic constriction injury (CCI), a rat model that mimics SNPP. Serotonin 44-63 solute carrier family 12 member 5 Rattus norvegicus 257-261 32844633-1 2020 THE AIM OF THE STUDY: Was to evaluate the effect of selective serotonin reuptake inhibitor fluoxetine on the production of cytokines interleukin-6 (IL-6) and interleukin-1beta (IL-1beta) by dendritic cells in multiple sclerosis (MS). Serotonin 62-71 interleukin 1 alpha Homo sapiens 177-185 31725281-6 2019 When implementing the bioassay for the screening of plasma, a pronounced receptor activation was already observed in blank samples, which could be ascribed to endogenous serotonin, as suggested by annihilation of this activity by a 5-HT2AR antagonist or after incubation with MAO-A (monoamine oxidase-A). Serotonin 170-179 monoamine oxidase A Homo sapiens 276-281 31725281-6 2019 When implementing the bioassay for the screening of plasma, a pronounced receptor activation was already observed in blank samples, which could be ascribed to endogenous serotonin, as suggested by annihilation of this activity by a 5-HT2AR antagonist or after incubation with MAO-A (monoamine oxidase-A). Serotonin 170-179 monoamine oxidase A Homo sapiens 283-302 31725281-7 2019 The presence and degradability by MAO-A of serotonin in plasma extracts were confirmed by LC-HRMS. Serotonin 43-52 monoamine oxidase A Homo sapiens 34-39 31541883-3 2019 The 5-HT1A receptor is a key protein in the brain serotonin system, modulating the release of 5-HT and other neurotransmitters. Serotonin 50-59 5-hydroxytryptamine receptor 1A Homo sapiens 4-19 30238388-0 2019 Alterations in the Serotonin and Dopamine Pathways by Cystathionine Beta Synthase Overexpression in Murine Brain. Serotonin 19-28 cystathionine beta-synthase Mus musculus 54-81 30238388-6 2019 Briefly, the serotonin pathway was modified by CBS overexpression in various brain areas in female mice but not in male mice. Serotonin 13-22 cystathionine beta-synthase Mus musculus 47-50 30693567-1 2019 OBJECTIVE: We have previously reported higher brain serotonin 1A (5-HT1A ) autoreceptor binding in antidepressant-naive patients with Major Depressive Disorder (MDD) compared with healthy volunteers, and a decrease in binding in MDD after selective serotonin reuptake inhibitor (SSRI) treatment. Serotonin 52-61 5-hydroxytryptamine receptor 1A Homo sapiens 66-72 31178828-2 2019 Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP). Serotonin 172-181 gonadotropin releasing hormone 1 Mus musculus 71-75 31178828-2 2019 Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP). Serotonin 172-181 gonadotropin releasing hormone 1 Mus musculus 96-100 30625007-11 2019 We show that serotonin produces this inhibition exclusively via 5-HT1D receptors, and yet these receptors are paradoxically mostly confined to C-fibers. Serotonin 13-22 5-hydroxytryptamine receptor 1D Rattus norvegicus 64-70 30807072-0 2019 Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm Major depression and anxiety are highly prevalent and involve chronic dysregulation of serotonin, but they remain poorly understood. Serotonin 216-225 5-hydroxytryptamine receptor 1A Homo sapiens 94-109 30807072-1 2019 Here, we review novel transcriptional (genetic, epigenetic) and posttranscriptional (microRNA, alternative splicing) mechanisms implicated in mental illness, focusing on a key serotonin-related regulator, the serotonin 1A (5-HT1A) receptor. Serotonin 176-185 5-hydroxytryptamine receptor 1A Homo sapiens 209-239 30917312-4 2019 Our search for receptors in Nppb neurons reveals that they express leukotriene, serotonin, and sphingosine-1-phosphate receptors. Serotonin 80-89 natriuretic peptide type B Mus musculus 28-32 30462556-9 2019 5-CT (5-HT1/7 agonist) and L-694,247 (5-HT1D agonist) mimicked the serotonin inhibitory effect while alpha-methyl-5-HT (5-HT2 agonist) was devoid of any action. Serotonin 67-76 5-hydroxytryptamine receptor 1D Rattus norvegicus 38-44 30470662-2 2019 Cariprazine, a dopamine D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, with preferential binding to D3 receptors, is approved for the treatment of adult patients with schizophrenia (US, Europe) and mania associated with bipolar I disorder (US). Serotonin 59-68 5-hydroxytryptamine receptor 1A Homo sapiens 69-84 30563469-4 2018 Both melatonin and serotonin locally induced the expression of the cell-wall-remodeling-related genes LBD16 and XTR6, thereby inducing LR development. Serotonin 19-28 xyloglucan endotransglycosylase 6 Arabidopsis thaliana 112-116 30409162-10 2018 RESULTS: Exposure of liver cancer cells to serotonin induced Notch signaling and autophagy, independent of AKT/mTOR pathway. Serotonin 43-52 mechanistic target of rapamycin kinase Mus musculus 111-115 30043181-2 2018 After the demonstrations that both cardiac neuronal and extraneuronal MAO-A contribute to the degradation of norepinephrine and serotonin, several studies attempted to determine the impact of MAO-A activity in the control of local concentration of the two biogenic amines and in their receptor-mediated effects. Serotonin 128-137 monoamine oxidase A Homo sapiens 70-75 30093565-1 2018 The serotonin-1A (5-HT1A) receptor is a key regulator of serotonergic activity and is implicated in mood and emotion. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 18-34 30093565-14 2018 The serotonin-1A receptor gene (HTR1A) is a regulator of serotonin, which is implicated in mood and emotion. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 32-37 30093565-14 2018 The serotonin-1A receptor gene (HTR1A) is a regulator of serotonin, which is implicated in mood and emotion. Serotonin 57-66 5-hydroxytryptamine receptor 1A Homo sapiens 32-37 30192450-3 2018 The antidepressant duloxetine, acting as a serotonin-norepinephrine reuptake inhibitor, is mainly metabolized via CYP1A2. Serotonin 43-52 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 114-120 30008960-7 2018 In contrast, examination of SERT, the gene product of which is a target for the SSRI-class of antidepressants, and MAO-A, which encodes the predominant catabolic enzyme in the serotonin pathway, reveals that their mRNAs are 51-59% repressed by 10 nM 1,25D treatment of RN46A-B14 cells. Serotonin 176-185 monoamine oxidase A Bos taurus 115-120 29899283-5 2018 An ELISA analysis revealed that the levels of serotonin were elevated in the serum and brain tissue of L. K71-fed mice. Serotonin 46-55 keratin 71 Mus musculus 106-109 29696773-8 2018 A homozygous, missense variant in tryptophan hydroxylase 1 may be clinically important as this gene encodes the rate limiting step in serotonin biosynthesis, a biologic pathway connected with mood disorders. Serotonin 134-143 tryptophan hydroxylase 1 Homo sapiens 34-58 29478144-7 2018 The MAOA gene encodes an enzyme which is involved in the catabolism of dopamine, norepinephrine, serotonin, and other monoaminergic neurotransmitters. Serotonin 97-106 monoamine oxidase A Homo sapiens 4-8 29851973-9 2018 Moreover, leptin associated with tryptophan in support of the possible role of leptin in the regulation of serotonin synthesis pathways in the gut. Serotonin 107-116 leptin Homo sapiens 10-16 29851973-9 2018 Moreover, leptin associated with tryptophan in support of the possible role of leptin in the regulation of serotonin synthesis pathways in the gut. Serotonin 107-116 leptin Homo sapiens 79-85 29141444-11 2018 CONCLUSION: The pro-inflammatory state of obesity in pregnancy may drive activation of IDO-1, resulting in diversion of TRP away from serotonin and melatonin production and toward KYN metabolites. Serotonin 134-143 indoleamine 2,3-dioxygenase 1 Homo sapiens 87-92 29365217-1 2018 BACKGROUND: Positron emission tomography (PET) studies in major depressive disorder (MDD) have reported higher serotonin 1A (5-HT1A ) autoreceptor binding in the raphe. Serotonin 111-120 5-hydroxytryptamine receptor 1A Homo sapiens 125-131 29295855-6 2018 Vasodilation by beta2 AR agonists occurred after pretreatment of pulmonary arteries with phenylephrine and serotonin, both agonists of alpha1 ARs, but was absent after preconstriction with the thromboxane analog U46619. Serotonin 107-116 adrenergic receptor, beta 2 Mus musculus 16-24 29617866-0 2018 Serotonin induces parathyroid hormone-related protein in goat mammary gland. Serotonin 0-9 parathyroid hormone-related protein Capra hircus 18-53 29166705-6 2018 The system allowed a limit of detection between 0.625 and 2.5 pg muL-1 for monoamine analytes and their metabolites, including dopamine, 3,4-dihydroxyphenylacetic acid, 3-methoxytyramine, homovanillic acid, norepinephrine, epinephrine, 3-methoxy-4-hydroxyphenylglycol, serotonin and 5-hydroxyindoleacetic acid. Serotonin 269-278 mitochondrial ubiquitin ligase activator of NFKB 1 Mus musculus 65-70 29331576-2 2018 We examined the normative distribution of SP and NK1R in the serotonergic (5-Hydroxytryptamine, [5-HT]) network of the human infant medulla during postnatal development, to provide a baseline to facilitate future analysis of the SP/NK1R system and its interaction with 5-HT within pediatric brainstem disorders in early life. Serotonin 75-94 tachykinin receptor 1 Homo sapiens 49-53 31757051-10 2019 The SMe1EC2M3-induced suppression of 5-HT, norepinephrine, and dopamine neurons was reversed by the antagonists of serotonin-1A (5-HT1A; WAY100135), alpha-2 adrenergic (alpha2, yohimbine), and dopamine-2 receptors (D2, haloperidol), respectively. Serotonin 115-124 5-hydroxytryptamine receptor 1A Homo sapiens 129-135 34938160-13 2021 Finally, two neurotransmitters, TRH, and 5-HT, which are both known to increase MN IME by TASK1 inhibition, stimulated ROCK2, and depressed background resting currents via Galphaq/ROCK2 signaling. Serotonin 41-45 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 119-124 34938160-13 2021 Finally, two neurotransmitters, TRH, and 5-HT, which are both known to increase MN IME by TASK1 inhibition, stimulated ROCK2, and depressed background resting currents via Galphaq/ROCK2 signaling. Serotonin 41-45 Rho-associated coiled-coil containing protein kinase 2 Rattus norvegicus 180-185 29017334-3 2018 CONCLUSIONS: Brexpiprazole and aripiprazole are both partial agonists at dopamine D2, and serotonin 5-HT1A and antagonists at serotonin 5-HT2A and noradrenergic alpha1B receptors. Serotonin 90-99 5-hydroxytryptamine receptor 1A Homo sapiens 100-106 34119772-0 2021 Colorimetry and SERS dual-mode sensing of serotonin based on functionalized gold nanoparticles. Serotonin 42-51 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 16-20 28807414-10 2018 Moreover, TRPV4-dependent chronic itch requires 5-hydroxytryptamine (5-HT) signaling secondary to activation of distinct 5-HT receptors in mice with allergic and those with nonallergic chronic itch conditions. Serotonin 48-67 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 10-15 31556016-1 2019 BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Serotonin 124-133 monoamine oxidase A Homo sapiens 16-36 31556016-1 2019 BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Serotonin 124-133 monoamine oxidase A Homo sapiens 38-43 34119772-1 2021 In this study, we reported a colorimetry and SERS dual-mode sensing of serotonin (5-HT) based on functionalized gold nanoparticles (AuNPs). Serotonin 71-80 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 45-49 34119772-1 2021 In this study, we reported a colorimetry and SERS dual-mode sensing of serotonin (5-HT) based on functionalized gold nanoparticles (AuNPs). Serotonin 82-86 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 45-49 31668390-0 2019 Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production. Serotonin 123-132 regulatory factor X, 6 Mus musculus 0-4 29375322-2 2017 It was previously demonstrated that the excitability of motoneurons was decreased when a spillover of serotonin could activate extrasynaptic 5-HT1A receptors at the axon initial segment (AIS) of motoneurons. Serotonin 102-111 5-hydroxytryptamine receptor 1A Homo sapiens 141-147 31668390-14 2019 On the contrary, Rfx6 represses Lmx1a and Tph1, two genes essential for serotonin biosynthesis. Serotonin 72-81 regulatory factor X, 6 Mus musculus 17-21 34726359-10 2021 Then we evaluated the co-presence of alpha-syn with serotonin (5-HT), expressed in EECs. Serotonin 63-67 synuclein alpha Homo sapiens 37-46 31421827-0 2019 Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway. Serotonin 121-130 sirtuin 1 Mus musculus 14-19 29424302-7 2018 Furthermore, depending on the tumor type, 5-HT1A receptor antagonists were shown to be capable of blocking the 5HT-induced increase in tumor growth. Serotonin 111-114 5-hydroxytryptamine receptor 1A Homo sapiens 42-57 31421827-0 2019 Inhibition of SIRT1 in hippocampal CA1 ameliorates PTSD-like behaviors in mice by protections of neuronal plasticity and serotonin homeostasis via NHLH2/MAO-A pathway. Serotonin 121-130 carbonic anhydrase 1 Mus musculus 35-38 34224867-5 2021 Increases in respiratory frequency are induced by microinjections of neurokinins, somatostatin as well by serotonin (5-HT) through an action on 5-HT1A and 5-HT3 receptors or the disinhibition of a GABAergic circuit. Serotonin 106-115 5-hydroxytryptamine receptor 1A Homo sapiens 144-150 31610810-6 2019 We demonstrate here that PAI-1 plays a key role in depression by a mechanism independent of the tissue-type Plasminogen Activator (tPA) - Brain-Derived Neurotrophic Factor (BDNF) axis, but associated with impaired metabolisms of serotonin and dopamine. Serotonin 229-238 serpin family E member 1 Homo sapiens 25-30 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Serotonin 68-77 monoamine oxidase A Homo sapiens 7-24 28293733-1 2018 Type A monoamine oxidase (MAOA) catabolizes monoamine transmitters, serotonin, norepinephrine and dopamine, and plays a major role in the onset, progression and therapy of neuropsychiatric disorders. Serotonin 68-77 monoamine oxidase A Homo sapiens 26-30 28293733-3 2018 The functional polymorphism of MAOA gene and genes in serotonin signal pathway are associated with depression. Serotonin 54-63 monoamine oxidase A Homo sapiens 31-35 28293733-5 2018 MAOA and serotonin regulate the prenatal development and postnatal maintenance of brain architecture and neurocircuit, as shown by MAOA-deficient humans and MAO knockout animal models. Serotonin 9-18 monoamine oxidase A Homo sapiens 131-135 31610810-7 2019 Our data also reveal that PAI-1 interferes with therapeutic responses to selective serotonin reuptake inhibitors (escitalopram, fluoxetine). Serotonin 83-92 serpin family E member 1 Homo sapiens 26-31 34224867-5 2021 Increases in respiratory frequency are induced by microinjections of neurokinins, somatostatin as well by serotonin (5-HT) through an action on 5-HT1A and 5-HT3 receptors or the disinhibition of a GABAergic circuit. Serotonin 117-121 5-hydroxytryptamine receptor 1A Homo sapiens 144-150 29490303-7 2018 In addition, beta-catenin can be regulated by neurotransmitters such as serotonin and dopamine. Serotonin 72-81 catenin beta 1 Homo sapiens 13-25 34771469-2 2021 In aggressive PANC-1 and MIA PaCa-2 cells, knock-down (KD) of EZH2, TPH1, or HTR7 induced a decrease in CSCs and recovery from gemcitabine resistance, while preconditioning of less aggressive Capan-1 cells with 5-HT induced gemcitabine resistance with increased expression of EZH2, TPH1, and 5-HT7. Serotonin 211-215 tryptophan hydroxylase 1 Homo sapiens 282-286 34625528-6 2021 The aim of this study was to use the construct pIRES-hrGFP-1a-Tph2-FLAG to treat CD1-male mice and to transfect HEK-293-cells and then to evaluate whether this treatment increases 5-HT production. Serotonin 180-184 CD1 antigen complex Mus musculus 81-84 29020418-11 2017 Extracellular serotonin levels were lower in the dorsal striatum of the dS-Shati/Nat8l and normal mice that were repeatedly administered a selective glutamate carboxypeptidase II inhibitor. Serotonin 14-23 N-acetyltransferase 8-like Mus musculus 75-80 29020418-11 2017 Extracellular serotonin levels were lower in the dorsal striatum of the dS-Shati/Nat8l and normal mice that were repeatedly administered a selective glutamate carboxypeptidase II inhibitor. Serotonin 14-23 N-acetyltransferase 8-like Mus musculus 81-86 31366729-8 2019 Using serotonin 5-HT1A receptors (5-HT1ARs) as a model receptor system, we found that ethanol dose-dependently inhibits 5-HT1AR internalization and that MDM2 knockdown reverses this effect. Serotonin 6-15 transformed mouse 3T3 cell double minute 2 Mus musculus 153-157 34588597-5 2021 Chronic treatment of Lrfn3-/- mice with fluoxetine, a selective serotonin reuptake inhibitor used to treat excessive fear memory that directly inhibits GluN2B-NMDARs, normalizes NMDAR function and contextual fear memory consolidation in Lrfn3-/- mice, although the GluN2B-specific NMDAR antagonist ifenprodil was not sufficient to reverse the enhanced fear memory consolidation. Serotonin 64-73 glutamate receptor, ionotropic, NMDA2B (epsilon 2) Mus musculus 152-158 31477731-0 2019 Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors. Serotonin 29-38 5-hydroxytryptamine receptor 1A Homo sapiens 48-54 28911850-8 2017 Further, it reversed the enhanced serum IL-1beta and IL-6 and reverted the increased activity of IDO as measured by ratio of hippocampal KYN/TRP and 5HT/TRP in stressed mice. Serotonin 149-152 indoleamine 2,3-dioxygenase 1 Mus musculus 97-100 34588597-5 2021 Chronic treatment of Lrfn3-/- mice with fluoxetine, a selective serotonin reuptake inhibitor used to treat excessive fear memory that directly inhibits GluN2B-NMDARs, normalizes NMDAR function and contextual fear memory consolidation in Lrfn3-/- mice, although the GluN2B-specific NMDAR antagonist ifenprodil was not sufficient to reverse the enhanced fear memory consolidation. Serotonin 64-73 glutamate receptor, ionotropic, NMDA1 (zeta 1) Mus musculus 178-183 28991152-6 2017 The proposed method was successfully validated, showing favorable parameters of sensitivity (limit of detection for serotonin was 2.32 ng mL-1), linearity (regression coefficient higher than 0.99), precision (repeatability of the migration time and peak area were in the range of 0.02-1.17% and 5.25-7.88%, respectively), and recovery (ranging in the interval of 90.0-93.6%). Serotonin 116-125 L1 cell adhesion molecule Mus musculus 138-142 34576341-0 2021 Blockade of Serotonin 5-HT6 Receptor Constitutive Activity Alleviates Cognitive Deficits in a Preclinical Model of Neurofibromatosis Type 1. Serotonin 12-21 neurofibromin 1 Mus musculus 115-139 28991152-8 2017 The determined concentrations of serotonin in such samples were in the range of 12.4-491.2 ng mL-1 that was in good agreement with literature data. Serotonin 33-42 L1 cell adhesion molecule Mus musculus 94-98 31253532-5 2019 The affinities for the selected serotonin (5-HT1A,5-HT2A,5-HT6,5-HT7) and dopamine (D2) receptors have been evaluated in vitro. Serotonin 32-41 5-hydroxytryptamine receptor 1A Homo sapiens 43-49 30885841-6 2019 Intracerebroventricular (icv) administration of 5-HT 30 min before LPS administration prevented hypotension and hypothermia, which were accompanied by reduced plasma NO, as well as plasma TNF-alpha, IL-1beta, IL-6, and IL-10 and spleen TNF-alpha and IL-10 levels. Serotonin 48-52 interleukin 10 Rattus norvegicus 219-224 30885841-6 2019 Intracerebroventricular (icv) administration of 5-HT 30 min before LPS administration prevented hypotension and hypothermia, which were accompanied by reduced plasma NO, as well as plasma TNF-alpha, IL-1beta, IL-6, and IL-10 and spleen TNF-alpha and IL-10 levels. Serotonin 48-52 interleukin 10 Rattus norvegicus 250-255 29046648-1 2017 It has been suggested that the metabolic enzyme indoleamine 2,3-dioxygenase (IDO) is a biological mediator of inflammation related to the psychopathology of depression, with a Kynurenine (KYN) increase in the Tryptophan (TRP) metabolic pathway, resulting in reduced Serotonin. Serotonin 266-275 indoleamine 2,3-dioxygenase 1 Homo sapiens 77-80 34576341-3 2021 The serotonin 5-HT6 receptor is a potentially relevant target in view of its ability to associate with neurofibromin and to engage the mTOR pathway to compromise cognition in several cognitive impairment paradigms. Serotonin 4-13 neurofibromin 1 Mus musculus 103-116 28921675-5 2017 These regionally specific alterations are accompanied by an enhanced active coping response during acute stress (forced swim), serotonin neuron Fos activity in the caudal dorsal raphe, and serotonin type 1A receptor-dependent feedback inhibition of the rostral dorsal raphe nuclei. Serotonin 127-136 FBJ osteosarcoma oncogene Mus musculus 144-147 34576341-3 2021 The serotonin 5-HT6 receptor is a potentially relevant target in view of its ability to associate with neurofibromin and to engage the mTOR pathway to compromise cognition in several cognitive impairment paradigms. Serotonin 4-13 mechanistic target of rapamycin kinase Mus musculus 135-139 31294376-1 2019 Background: Tryptophan hydroxylase (TPH)1 catalyzes the biosynthesis of serotonin (5-hydroxytrptamine; 5-HT) in enterochromaffin (EC) cells, the predominant source of gut 5-HT. Serotonin 72-81 tryptophan hydroxylase 1 Homo sapiens 36-41 34368536-6 2021 To evaluate calcification progress, calcium and collagen deposits along with the expression of protein markers, including the rate-limiting enzyme of serotonin synthesis (tryptophan hydroxylase 1 (TPH1)), were assessed. Serotonin 150-159 tryptophan hydroxylase 1 Homo sapiens 197-201 31045220-2 2019 Polymorphisms in genes coding for the serotonin receptor subtype 1A (HTR1A), the serotonin transporter (SLC6A4), and the serotonin degrading enzyme monoamine oxidase A (MAOA) are associated with anxiety, impulsivity, and neurotic personality in humans. Serotonin 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 69-74 28751217-3 2017 Moreover, it is not known if the two tryptophan hydroxylase isoforms (TPH1 and TPH2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 70-74 28751217-10 2017 This study demonstrates that both TPH1 and TPH2 are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development. Serotonin 156-165 tryptophan hydroxylase 1 Homo sapiens 34-38 34251588-6 2022 Tea interventions significantly inhibited the CCl4-provoked increase of duodenal 5-HT and tryptophan hydroxylase and hepatic 5-HT and 5-HTR2A/2B levels. Serotonin 81-85 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 28858536-2 2017 In this present synthesis, we integrate previous perspectives with new and older data to create a novel bipartite model centred on the view that serotonin neurotransmission enhances two distinct adaptive responses to adversity, mediated in large part by its two most prevalent and researched brain receptors: the 5-HT1A and 5-HT2A receptors. Serotonin 145-154 5-hydroxytryptamine receptor 1A Homo sapiens 313-325 28647411-2 2017 Of the various serotonin receptors, 5-HT1A receptors are relevant to AD as they are highly expressed in the human hippocampus and are known to be involved in the regulation of memory processes. Serotonin 15-24 5-hydroxytryptamine receptor 1A Homo sapiens 36-42 29353534-1 2019 Objectives: Recent research suggested an influence of diminished central nervous serotonin (5-HT) synthesis on the leptin axis via immunological mechanisms in healthy adult females. Serotonin 81-90 leptin Homo sapiens 115-121 29353534-1 2019 Objectives: Recent research suggested an influence of diminished central nervous serotonin (5-HT) synthesis on the leptin axis via immunological mechanisms in healthy adult females. Serotonin 92-96 leptin Homo sapiens 115-121 32550449-0 2019 The protein kinase G orthologs, EGL-4 and PKG-2, mediate serotonin-induced paralysis of C. elegans. Serotonin 57-66 cGMP-dependent protein kinase;cGMP-dependent protein kinase egl-4 Caenorhabditis elegans 32-37 28855642-5 2017 Moreover, the deficiency of serotonin reduced the levels of PAI-1 and fibrinogen, and raised the t-PA and t-PA/PAI levels in the peritoneal fluids. Serotonin 28-37 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 60-65 34251588-6 2022 Tea interventions significantly inhibited the CCl4-provoked increase of duodenal 5-HT and tryptophan hydroxylase and hepatic 5-HT and 5-HTR2A/2B levels. Serotonin 125-129 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 0-3 28855642-5 2017 Moreover, the deficiency of serotonin reduced the levels of PAI-1 and fibrinogen, and raised the t-PA and t-PA/PAI levels in the peritoneal fluids. Serotonin 28-37 serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus 60-63 34251588-8 2022 Se-enriched green tea had a more pronounced improvement in liver ECM deposition and scar formation and peripheral 5-HT signals than regular green tea. Serotonin 114-118 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 18-21 34202161-4 2021 To discover candidate genes involved in PG neurogenesis, the transcriptome profiling of sacral NC and developing PG was performed, and we identified the enrichment of the type 3 serotonin receptor (5-HT3, encoded by Htr3a and Htr3b). Serotonin 178-187 5-hydroxytryptamine receptor 3B Homo sapiens 226-231 28196617-6 2017 Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression. Serotonin 6-15 5-hydroxytryptamine receptor 1A Homo sapiens 43-49 28196617-6 2017 Since Serotonin (5-HT), especially through 5-HT1A, and Galanin receptors interact at both pre-and postsynaptic level, the development of drugs targeting potential GAL1-GAL2-5-HT1A heteroreceptor complexes linked to the raphe-hippocampal 5-HT neurons may represent new treatment strategies in depression. Serotonin 6-15 galectin 1 Homo sapiens 163-167 28343185-3 2017 Serotonin (5-hydroxytryptamine [5-HT]) has multiple pharmacological tools, well-characterized downstream signaling in mammals" species, and established 5-HT neural markers showing new insights about memory functions and dysfunctions, including receptors (5-HT1A/1B/1D, 5-HT2A/2B/2C, and 5-HT3-7), transporter (serotonin transporter [SERT]) and volume transmission present in brain areas involved in memory. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 255-261 31192261-0 2019 Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women. Serotonin 9-18 leptin receptor Homo sapiens 61-76 28343185-3 2017 Serotonin (5-hydroxytryptamine [5-HT]) has multiple pharmacological tools, well-characterized downstream signaling in mammals" species, and established 5-HT neural markers showing new insights about memory functions and dysfunctions, including receptors (5-HT1A/1B/1D, 5-HT2A/2B/2C, and 5-HT3-7), transporter (serotonin transporter [SERT]) and volume transmission present in brain areas involved in memory. Serotonin 11-30 5-hydroxytryptamine receptor 1A Homo sapiens 255-261 34060807-6 2021 The results of liver transcriptomic analysis and correlation analysis showed that the Glu, DA, 5-HT, and GABA were impacted by 68 liver genes which were mainly enriched in three pathways including circadian rhythm, serotonergic synapse, and p53 signaling pathway. Serotonin 95-99 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 241-244 28388475-1 2017 The geometry and electronic structures of protonated serotonin have been investigated by the aim of MP2 and CC2 methods. Serotonin 53-62 tryptase pseudogene 1 Homo sapiens 100-103 31019306-5 2019 Here, we present high-resolution room-temperature X-ray free electron laser (XFEL) structures of MT1 in complex with four agonists: the insomnia drug ramelteon11, two melatonin analogues, and the mixed melatonin-serotonin antidepressant agomelatine12,13. Serotonin 212-221 metallothionein 1I, pseudogene Homo sapiens 97-100 30808545-3 2019 Previous research on serotonergic (5-HT) neurons identified microRNA-26a (miR-26a) targeting of the serotonin autoreceptor, 5-HT receptor 1A (HTR1A). Serotonin 35-39 microRNA 26a-1 Mus musculus 74-81 30808545-3 2019 Previous research on serotonergic (5-HT) neurons identified microRNA-26a (miR-26a) targeting of the serotonin autoreceptor, 5-HT receptor 1A (HTR1A). Serotonin 100-109 microRNA 26a-1 Mus musculus 74-81 30713268-1 2019 Serotonin (5-hydroxytryptamine; 5-HT) can induce hepatocyte DNA synthesis and proliferation by autocrine secretion of transforming growth factor (TGF)-alpha through 5-HT2B receptor/phospholipase C (PLC)/Ca2+ and a signaling pathway involving epidermal growth factor (EGF)/TGF-alpha receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase 2 (ERK2)/mammalian target of rapamycin (mTOR). Serotonin 0-9 epidermal growth factor Homo sapiens 267-270 34085306-1 2021 The hormone melatonin is synthesized from serotonin by two enzymatic reactions (AANAT and ASMT/HIOMT) in the pineal gland following a circadian rhythm with low levels during the day and high levels at night. Serotonin 42-51 arylalkylamine N-acetyltransferase Mus musculus 80-85 30713268-1 2019 Serotonin (5-hydroxytryptamine; 5-HT) can induce hepatocyte DNA synthesis and proliferation by autocrine secretion of transforming growth factor (TGF)-alpha through 5-HT2B receptor/phospholipase C (PLC)/Ca2+ and a signaling pathway involving epidermal growth factor (EGF)/TGF-alpha receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase 2 (ERK2)/mammalian target of rapamycin (mTOR). Serotonin 11-30 epidermal growth factor Homo sapiens 267-270 28472632-10 2017 MDMA-induced place preference, behavioral sensitization, and an increase in the levels of extracellular serotonin and dopamine within the nucleus accumbens, were attenuated in BDNF heterozygous knockout mice. Serotonin 104-113 brain derived neurotrophic factor Mus musculus 176-180 34122006-8 2021 A series of experiments further confirmed that Indoleamine 2,3 dioxygenase (IDO)/Kynurenine (Kyn)/Aryl hydrocarbon receptor (AhR) expression was high in the BP group, while Tryptophan hydroxylase 1(TpH1)/5-hydroxytryptamine (5-HT) only changed in the combined group. Serotonin 225-229 indoleamine 2,3-dioxygenase 1 Homo sapiens 47-74 28314816-1 2017 The atypical vesicular glutamate transporter type 3 (VGLUT3) is expressed by subpopulations of neurons using acetylcholine, GABA, or serotonin as neurotransmitters. Serotonin 133-142 solute carrier family 17 member 8 Homo sapiens 53-59 28073937-8 2017 These Tac1-Pet1 neurons may act downstream of Egr2-Pet1 serotonergic neurons, which were previously established in respiratory chemoreception, but do not innervate respiratory motor nuclei.SIGNIFICANCE STATEMENT Serotonin (5-HT) neurons modulate physiological processes and behaviors as diverse as body temperature, respiration, aggression, and mood. Serotonin 212-221 tachykinin 1 Mus musculus 6-10 30712943-7 2019 These results suggest that Cdk5-p35 modulates 5-HT signaling through phosphorylation-dependent degradation of 5-HTlAR. Serotonin 46-50 cyclin dependent kinase 5 Homo sapiens 27-31 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Serotonin 90-94 monoamine oxidase A Homo sapiens 24-43 34093864-6 2021 Among them, we picked out HTR1E, one member of 5-HT receptor family specifically expressed in the ovary and endometrium in addition to brain. Serotonin 47-51 5-hydroxytryptamine (serotonin) receptor 1E Mus musculus 26-31 30852703-4 2019 Finally, the density of monoamine oxidase-A (MAO-A), a mitochondrial enzyme that degrades 5-HT, norepinephrine, and dopamine (DA), was reported as lower in the OFC and ventral striatum of ASPD. Serotonin 90-94 monoamine oxidase A Homo sapiens 45-50 28073937-8 2017 These Tac1-Pet1 neurons may act downstream of Egr2-Pet1 serotonergic neurons, which were previously established in respiratory chemoreception, but do not innervate respiratory motor nuclei.SIGNIFICANCE STATEMENT Serotonin (5-HT) neurons modulate physiological processes and behaviors as diverse as body temperature, respiration, aggression, and mood. Serotonin 212-221 early growth response 2 Mus musculus 46-50 34093864-12 2021 Furthermore, chronic stress results in significantly decreased serotonin in the ovary and the enhanced OC growth and peritoneal dissemination in mice, which can be strongly inhibited by specific HTR1E agonist or the SRC inhibitor. Serotonin 63-72 5-hydroxytryptamine (serotonin) receptor 1E Mus musculus 195-200 28088287-8 2017 Monoaminergic analysis using high-performance liquid chromatography indicated that Igfbp3-null mice had lower levels of dopamine and serotonin compared with wild-type mice, suggesting an abnormal monoaminergic neurotransmission. Serotonin 133-142 insulin-like growth factor binding protein 3 Mus musculus 83-89 30899432-4 2019 These hypermethylated genes were significantly associated with neuronal pathways such as the GABA receptor and serotonin signaling pathways. Serotonin 111-120 GABA type A receptor-associated protein Homo sapiens 93-106 34093864-12 2021 Furthermore, chronic stress results in significantly decreased serotonin in the ovary and the enhanced OC growth and peritoneal dissemination in mice, which can be strongly inhibited by specific HTR1E agonist or the SRC inhibitor. Serotonin 63-72 Rous sarcoma oncogene Mus musculus 216-219 35523285-7 2022 The enzymes that convert serotonin to melatonin, i.e., arylalkylamine-N-acetyltransferase (AANAT) and acetylserotonin-O-methyltransferase, have been identified in brain mitochondria which, when incubated with serotonin, also form melatonin. Serotonin 25-34 arylalkylamine N-acetyltransferase Mus musculus 55-89 35523285-7 2022 The enzymes that convert serotonin to melatonin, i.e., arylalkylamine-N-acetyltransferase (AANAT) and acetylserotonin-O-methyltransferase, have been identified in brain mitochondria which, when incubated with serotonin, also form melatonin. Serotonin 25-34 arylalkylamine N-acetyltransferase Mus musculus 91-96 27344941-2 2017 Aplysia Sec7 protein (ApSec7), a guanine nucleotide exchange factor for ARF1 and ARF6, induces neurite outgrowth and plays a key role in 5-hydroxyltryptamine-induced neurite growth and synaptic facilitation in Aplysia sensory-motor synapses. Serotonin 137-157 ADP ribosylation factor 6 Homo sapiens 81-85 30552180-14 2019 These results suggest that markedly reduced 5-HT1A autoreceptors may provide a marker for aberrant response to SSRI treatment.SIGNIFICANCE STATEMENT Serotonin-selective reuptake inhibitors (SSRIs) are effective in treating anxiety and depression in humans and mouse models. Serotonin 149-158 5-hydroxytryptamine receptor 1A Homo sapiens 44-50 35523285-7 2022 The enzymes that convert serotonin to melatonin, i.e., arylalkylamine-N-acetyltransferase (AANAT) and acetylserotonin-O-methyltransferase, have been identified in brain mitochondria which, when incubated with serotonin, also form melatonin. Serotonin 209-218 arylalkylamine N-acetyltransferase Mus musculus 55-89 35523285-7 2022 The enzymes that convert serotonin to melatonin, i.e., arylalkylamine-N-acetyltransferase (AANAT) and acetylserotonin-O-methyltransferase, have been identified in brain mitochondria which, when incubated with serotonin, also form melatonin. Serotonin 209-218 arylalkylamine N-acetyltransferase Mus musculus 91-96 35248961-5 2022 We identified two target proteins that potentially interacted with carbaryl, the alpha2B adrenoceptor (ADRA2B) and the serotonin 2B receptor (HTR2B). Serotonin 119-128 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Danio rerio 142-147 30777054-11 2019 Both neuropeptides were found to increase expression of the specific serotonin (5HT) receptor htr2a, the activation of which has previously been associated with cellular proliferation, suggesting that production of these factors by osteosarcoma cells may act to sensitize tumors to circulating 5HT of local and/or enteric origin. Serotonin 80-83 5-hydroxytryptamine receptor 2A Canis lupus familiaris 94-99 28147271-0 2017 Serotonin Signaling through Prefrontal Cortex 5-HT1A Receptors during Adolescence Can Determine Baseline Mood-Related Behaviors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 46-52 35379903-6 2022 5-hydroxytryptamine (5-HT) in turn activates PGE2 production in a PGE2+ macrophage subset through its receptors HTR2A/3 A; and PGE2 via binding its receptors EP1/EP4, promotes Wnt/beta-catenin signaling in ISCs to promote their self-renewal. Serotonin 0-19 prostaglandin E receptor 1 Homo sapiens 158-161 27986565-1 2017 In blood vessels, serotonin 5-HT2B receptors mainly mediate relaxation, although their activation by the selective agonist BW723C86 is known to exert contraction of aorta in deoxycorticosterone acetate (DOCA)-salt and N(omega)-nitro-l-arginine (l-NAME) hypertensive rats [Russel et al., 2002; Banes et al., 2003] and in mice with type 2 diabetes [Nelson et al., 2012]. Serotonin 18-27 5-hydroxytryptamine receptor 2B Rattus norvegicus 28-34 27752775-10 2017 Finally, genetic deletion of the eEF2K ortholog efk-1 reduced oxidative stress, and improved chemotaxis and serotonin sensitivity in C. elegans expressing human Abeta42 in neurons. Serotonin 108-117 Eukaryotic elongation factor 2 kinase Caenorhabditis elegans 48-53 31304429-4 2019 The biogenic aldehydes produced from dopamine, norepinephrine and serotonin are known to be toxic, generate reactive oxygen species and/or cause aggregation of proteins such as alpha-synuclein. Serotonin 66-75 synuclein alpha Homo sapiens 177-192 30697191-8 2018 Recent studies show that a subset of ECCs is indeed mechanosensitive and that Piezo2 mechanosensitive ion channels are necessary for coupling force to serotonin release. Serotonin 151-160 piezo type mechanosensitive ion channel component 2 Homo sapiens 78-84 35379903-6 2022 5-hydroxytryptamine (5-HT) in turn activates PGE2 production in a PGE2+ macrophage subset through its receptors HTR2A/3 A; and PGE2 via binding its receptors EP1/EP4, promotes Wnt/beta-catenin signaling in ISCs to promote their self-renewal. Serotonin 0-19 prostaglandin E receptor 4 Homo sapiens 162-165 27814296-10 2017 Together, these findings demonstrate that reduced BMD occurs earlier than overt degeneration in a tau-based AD model and that pathological changes in tau phosphorylation occur in the serotonin-producing neurons of the brainstem raphe in these mice. Serotonin 183-192 microtubule associated protein tau Homo sapiens 150-153 35379903-6 2022 5-hydroxytryptamine (5-HT) in turn activates PGE2 production in a PGE2+ macrophage subset through its receptors HTR2A/3 A; and PGE2 via binding its receptors EP1/EP4, promotes Wnt/beta-catenin signaling in ISCs to promote their self-renewal. Serotonin 0-19 catenin beta 1 Homo sapiens 180-192 35379903-6 2022 5-hydroxytryptamine (5-HT) in turn activates PGE2 production in a PGE2+ macrophage subset through its receptors HTR2A/3 A; and PGE2 via binding its receptors EP1/EP4, promotes Wnt/beta-catenin signaling in ISCs to promote their self-renewal. Serotonin 21-25 prostaglandin E receptor 1 Homo sapiens 158-161 35379903-6 2022 5-hydroxytryptamine (5-HT) in turn activates PGE2 production in a PGE2+ macrophage subset through its receptors HTR2A/3 A; and PGE2 via binding its receptors EP1/EP4, promotes Wnt/beta-catenin signaling in ISCs to promote their self-renewal. Serotonin 21-25 prostaglandin E receptor 4 Homo sapiens 162-165 27392819-5 2017 Activation of Piezo2 by mechanical forces results in a characteristic ionic current, the release of serotonin and stimulation of gastrointestinal secretion. Serotonin 100-109 piezo type mechanosensitive ion channel component 2 Homo sapiens 14-20 35379903-6 2022 5-hydroxytryptamine (5-HT) in turn activates PGE2 production in a PGE2+ macrophage subset through its receptors HTR2A/3 A; and PGE2 via binding its receptors EP1/EP4, promotes Wnt/beta-catenin signaling in ISCs to promote their self-renewal. Serotonin 21-25 catenin beta 1 Homo sapiens 180-192 27392819-6 2017 Piezo2 inhibition by drugs or molecular knockdown decreases mechanosensitive currents, serotonin release and downstream physiological effects. Serotonin 87-96 piezo type mechanosensitive ion channel component 2 Homo sapiens 0-6 35398789-6 2022 On the other hand, the analysis of data from 3 studies describing serum leptin levels in PE patients before and after treatment with selective serotonin reuptake inhibitors (SSRIs) showed that there was a significant decrease with leptin levels in PE patients after treatment (WMD (95%CI) = 22.06 (17.21, 26.92), P < .001). Serotonin 143-152 leptin Homo sapiens 72-78 26995730-2 2017 The balance between the production of the two types of metabolites is controlled by key rate-limiting enzymes such as indoleamine-2,3-dioxygenase (IDO-1), and in turn, molecular signals such as interferon-gamma (IFN-gamma), which activate the KP metabolism of tryptophan by this enzyme, as opposed to alternative pathways for serotonin and melatonin production. Serotonin 326-335 indoleamine 2,3-dioxygenase 1 Homo sapiens 147-152 35398789-6 2022 On the other hand, the analysis of data from 3 studies describing serum leptin levels in PE patients before and after treatment with selective serotonin reuptake inhibitors (SSRIs) showed that there was a significant decrease with leptin levels in PE patients after treatment (WMD (95%CI) = 22.06 (17.21, 26.92), P < .001). Serotonin 143-152 leptin Homo sapiens 231-237 27821364-1 2016 The monoamine oxidases (MAOA/B) and catechol-O-methyltransferase (COMT) enzymes break down regulatory components within serotonin and dopamine pathways, and polymorphisms within these genes are candidates for OCD susceptibility. Serotonin 120-129 monoamine oxidase A Homo sapiens 24-28 35610220-0 2022 Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A. Serotonin 63-72 5-hydroxytryptamine receptor 5A Homo sapiens 82-88 28442790-4 2016 Therefore, we evaluated the fatigue symptoms, classified PD patients into fatigue group and non-fatigue group, and detected the levels of serotonin, iron and related proteins in CSF and serum. Serotonin 138-147 colony stimulating factor 2 Homo sapiens 178-181 28442790-5 2016 In CSF, 5-HT level is significantly decreased and the levels of iron and transferrin are dramatically increased in fatigue group. Serotonin 8-12 colony stimulating factor 2 Homo sapiens 3-6 28442790-6 2016 In fatigue group, mental fatigue score is negatively correlated with 5-HT level in CSF, and positively correlated with the scores of depression and excessive daytime sleepiness, and disease duration, also, mental fatigue is positively correlated with the levels of iron and transferrin in CSF. Serotonin 69-73 colony stimulating factor 2 Homo sapiens 83-86 35610220-1 2022 5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the Gi/o protein. Serotonin 56-60 5-hydroxytryptamine receptor 5A Homo sapiens 0-31 28442790-7 2016 Transferrin level is negatively correlated with 5-HT level in CSF. Serotonin 48-52 colony stimulating factor 2 Homo sapiens 62-65 35610220-1 2022 5-hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals through the Gi/o protein. Serotonin 56-60 5-hydroxytryptamine receptor 5A Homo sapiens 33-39 35610220-3 2022 5-HT5A is the only Gi/o-coupled 5-HT receptor subtype lacking a high-resolution structure, which hampers the mechanistic understanding of ligand binding and Gi/o coupling for 5-HT5A. Serotonin 32-36 5-hydroxytryptamine receptor 5A Homo sapiens 0-6 35610220-3 2022 5-HT5A is the only Gi/o-coupled 5-HT receptor subtype lacking a high-resolution structure, which hampers the mechanistic understanding of ligand binding and Gi/o coupling for 5-HT5A. Serotonin 32-36 5-hydroxytryptamine receptor 5A Homo sapiens 175-181 27980071-5 2017 Consistent with a specific role for PKM Apl I in activity-dependent facilitation, live imaging FRET-based cleavage assays reveal that activity leads to cleavage of the classical PKC Apl I, but not the atypical PKC Apl III in the sensory neuron varicosities of Aplysia In contrast, massed intermediate facilitation (m-ITF) induced by 10 min of 5HT is sufficient for cleavage of the atypical PKC Apl III in the motor neuron. Serotonin 343-346 pyruvate kinase M1/2 Homo sapiens 36-39 35610220-7 2022 These findings provide comprehensive insights into the ligand binding and G protein coupling of Gi/o-coupled 5-HT receptors and offer a template for the design of 5-HT5A-selective drugs. Serotonin 109-113 5-hydroxytryptamine receptor 5A Homo sapiens 163-169 35611784-1 2022 BACKGROUND: Serotonin/5-HT antagonist and reuptake inhibitors (SARIs) ameliorate depression by increasing the terminal 5-HT through the activation of somatodendritic 5-HT1A autoreceptors. Serotonin 12-21 5-hydroxytryptamine receptor 1A Homo sapiens 166-172 28018238-5 2016 Approximately 30% of the c-FOS-positive cells in the parapyramidal group were serotoninergic, whereas only a small portion were labeled for serotonin in the raphe magnus nucleus. Serotonin 78-87 FBJ osteosarcoma oncogene Mus musculus 25-30 35611784-1 2022 BACKGROUND: Serotonin/5-HT antagonist and reuptake inhibitors (SARIs) ameliorate depression by increasing the terminal 5-HT through the activation of somatodendritic 5-HT1A autoreceptors. Serotonin 22-26 5-hydroxytryptamine receptor 1A Homo sapiens 166-172 35611784-1 2022 BACKGROUND: Serotonin/5-HT antagonist and reuptake inhibitors (SARIs) ameliorate depression by increasing the terminal 5-HT through the activation of somatodendritic 5-HT1A autoreceptors. Serotonin 119-123 5-hydroxytryptamine receptor 1A Homo sapiens 166-172 35624030-2 2022 Reported axonal and synaptic morphological alterations in serotonin (5-HT) neurons after selective inactivation of Lmx1b/Pet1 transcriptional networks may help to understand aging and neurodegenerative processes. Serotonin 58-67 LIM homeobox transcription factor 1 beta Homo sapiens 115-120 27734680-1 2016 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines, such as dopamine, serotonin, and noradrenaline (NA), which is why they have been extensively implicated in the etiology and course of various neurodegenerative disorders and, accordingly, used as primary pharmacological targets to treat these debilitating cognitive diseases. Serotonin 120-129 monoamine oxidase A Homo sapiens 0-33 27511837-6 2016 In all neurons investigated, 5HT potentiated capsaicin-evoked currents through TRPV1 channels, an effect that was attenuated by antagonists at 5HT2A (4 F 4 PP), 5HT2B (SB 204741), as well as 5HT2C (RS 102221) receptors. Serotonin 29-32 5-hydroxytryptamine receptor 2B Rattus norvegicus 161-166 35624030-2 2022 Reported axonal and synaptic morphological alterations in serotonin (5-HT) neurons after selective inactivation of Lmx1b/Pet1 transcriptional networks may help to understand aging and neurodegenerative processes. Serotonin 69-73 LIM homeobox transcription factor 1 beta Homo sapiens 115-120 27695066-7 2016 Recent studies in humans and mutant mouse models suggest biological epistasis between BDNF and genes involved in serotonin regulation. Serotonin 113-122 brain derived neurotrophic factor Mus musculus 86-90 35286016-0 2022 Design, synthesis, and characterization of a novel fluoroprobe for live human islet cell imaging of serotonin 5-HT1A receptor. Serotonin 100-109 5-hydroxytryptamine receptor 1A Homo sapiens 110-125 35286016-2 2022 Among the 5-HT receptor subtype found in pancreatic islets, serotonin receptor 1A (5-HT 1A ) demonstrates a unique ability to inhibit beta-cell insulin secretion. Serotonin 10-14 5-hydroxytryptamine receptor 1A Homo sapiens 83-90 27424782-3 2016 Exposure to serotonin or the reuptake inhibitor fluoxetine increased runx1 expression and Flk1(+)/cMyb(+) HSPCs independent of peripheral innervation. Serotonin 12-21 RUNX family transcription factor 1 Homo sapiens 69-74 35286016-2 2022 Among the 5-HT receptor subtype found in pancreatic islets, serotonin receptor 1A (5-HT 1A ) demonstrates a unique ability to inhibit beta-cell insulin secretion. Serotonin 60-69 5-hydroxytryptamine receptor 1A Homo sapiens 83-90 35600957-5 2022 Changes in the expression of IL-1beta, TNF-alpha, and BDNF in NG2 cells were detected after the addition of 5-HT receptor specific blockers and phospholipase C (PLC) specific activators and inhibitors. Serotonin 108-112 chondroitin sulfate proteoglycan 4 Rattus norvegicus 62-65 35600957-7 2022 5-HT treatment of NG2 cells significantly reduced the expression of IL-1beta and BDNF mRNA and increased the expression of TNF-alpha. Serotonin 0-4 chondroitin sulfate proteoglycan 4 Rattus norvegicus 18-21 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Serotonin 209-218 monoamine oxidase A Homo sapiens 130-149 35600957-8 2022 The 5-HT receptor specific inhibitors alverine citrate, ketanserin, ondansetron and SB-399885 blocked the regulatory effects of 5-HT on NG2 cells. Serotonin 4-8 chondroitin sulfate proteoglycan 4 Rattus norvegicus 136-139 26776902-2 2016 In particular, converging lines of evidence have documented that these maladaptive manifestations of aggression are influenced by monoamine oxidase A (MAOA), the enzyme that catalyzes the degradation of brain serotonin, norepinephrine and dopamine. Serotonin 209-218 monoamine oxidase A Homo sapiens 151-155 35600957-8 2022 The 5-HT receptor specific inhibitors alverine citrate, ketanserin, ondansetron and SB-399885 blocked the regulatory effects of 5-HT on NG2 cells. Serotonin 128-132 chondroitin sulfate proteoglycan 4 Rattus norvegicus 136-139 35600957-10 2022 These results indicated that 5-HT affected IL-1beta, TNF-alpha, and BDNF secretion from NG2 cells via the 5-HT1A, 5-HT2A, 5-HT3, 5-HT6 receptors and the PLC signaling pathway. Serotonin 29-33 chondroitin sulfate proteoglycan 4 Rattus norvegicus 88-91 35475616-4 2022 Pu-erh tea boosted the indole and 5-hydroxytryptamine pathways of tryptophan metabolism via the gut-liver-brain axis. Serotonin 34-53 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 7-10 27471444-8 2016 Inhibitors that act mainly on MAO A are used in the treatment of depression, due to their ability to raise serotonin concentrations, while MAO B inhibitors decrease dopamine degradation and improve motor control in patients with Parkinson disease. Serotonin 107-116 monoamine oxidase A Homo sapiens 30-35 27144435-5 2016 Tryptophan hydroxylase 1 (TPH1), the rate limit enzyme in serotonin synthesis, was one of the genes which expression was reduced in DHT-treated SE cells. Serotonin 58-67 tryptophan hydroxylase 1 Homo sapiens 0-24 35475616-7 2022 Collectively, 0.25% (w/v) Pu-erh tea has the potential to prevent CRD by promoting indole and 5-HT pathways of tryptophan metabolism and signaling interactions in the gut-liver-brain axis. Serotonin 94-98 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 33-36 27144435-5 2016 Tryptophan hydroxylase 1 (TPH1), the rate limit enzyme in serotonin synthesis, was one of the genes which expression was reduced in DHT-treated SE cells. Serotonin 58-67 tryptophan hydroxylase 1 Homo sapiens 26-30 35181916-8 2022 We found that critical developmental periods of serotonin depletion caused degeneration and swelling of neurons as well as significant neuronal loss in the hippocampal CA1, CA3, and dentate gyrus (DG) areas. Serotonin 48-57 carbonic anhydrase 1 Rattus norvegicus 168-171 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 69-75 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 monoamine oxidase A Homo sapiens 135-154 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 monoamine oxidase A Homo sapiens 156-161 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 33-42 5-hydroxytryptamine receptor 1A Homo sapiens 69-75 35573352-2 2022 Cariprazine is a partial agonist at dopamine receptors D2 and D3 and serotonin receptor 5HT1A and an antagonist at serotonin receptors 5HT2B and 5HT2A. Serotonin 69-78 5-hydroxytryptamine receptor 1A Homo sapiens 88-93 27274197-5 2016 Brexpiprazole is a dopamine D-2 partial agonist with potent activity at the serotonin 5HT1A and 5HT2A and noradrenergic alpha-1B and alpha-2C receptors. Serotonin 76-85 5-hydroxytryptamine receptor 1A Homo sapiens 86-101 35473609-0 2022 Tryptophan hydroxylase 1 drives glioma progression by modulating the serotonin/L1CAM/NF-kappaB signaling pathway. Serotonin 69-78 tryptophan hydroxylase 1 Homo sapiens 0-24 35473609-9 2022 Mechanistically, TPH-1 increased the production of serotonin in glioma cells. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 17-22 26956991-7 2016 The fluoxetine effect on sleep fragmentation, but not on daytime rest, was modified by the monkey"s genotype for polymorphisms of monoamine oxidase A (MAOA), an enzyme that metabolizes serotonin. Serotonin 185-194 monoamine oxidase A Homo sapiens 130-149 26956991-7 2016 The fluoxetine effect on sleep fragmentation, but not on daytime rest, was modified by the monkey"s genotype for polymorphisms of monoamine oxidase A (MAOA), an enzyme that metabolizes serotonin. Serotonin 185-194 monoamine oxidase A Homo sapiens 151-155 35473609-12 2022 CONCLUSION: Taken together, these data suggested that TPH-1 facilitated cellular proliferation, migration, and chemoresistance in glioma through the serotonin/L1CAM/NF-kappaB pathway. Serotonin 149-158 tryptophan hydroxylase 1 Homo sapiens 54-59 35496291-6 2022 Moreover, MRW activated the 5-HT pathway by increasing the levels of 5-HT, 5-HIAA, 5-HT4R, CFTR, cAMP, and PKA in the colon tissue of STC rats. Serotonin 28-32 CF transmembrane conductance regulator Rattus norvegicus 91-95 27016479-0 2016 Serotonin suppresses beta-casein expression via PTP1B activation in human mammary epithelial cells. Serotonin 0-9 casein beta Homo sapiens 21-32 35294258-3 2022 IDO1 inhibition resulted in efficient blockade of the kynurenine pathway of tryptophan degradation and was accompanied by a metabolic adaptation that shunted tryptophan catabolism toward the serotonin pathway. Serotonin 191-200 indoleamine 2,3-dioxygenase 1 Homo sapiens 0-4 27020886-3 2016 In particular, the LC achiral method developed, employs a pentafluorinated silica based column (Discovery HS-F5) to separate dopamine, acetylcholine, serotonin, (+-)-1 and its two hepatic metabolites. Serotonin 150-159 heat shock transcription factor 5 Homo sapiens 106-111 26820599-0 2016 Increased levels of brain serotonin correlated with MMP-9 activity and IL-4 levels resulted in severe experimental autoimmune encephalomyelitis (EAE) in obese mice. Serotonin 26-35 interleukin 4 Mus musculus 71-75 35300211-0 2022 SAHA Alleviates Diarrhea-Predominant Irritable Bowel Syndrome Through Regulation of the p-STAT3/SERT/5-HT Signaling Pathway. Serotonin 101-105 signal transducer and activator of transcription 3 Rattus norvegicus 90-95 26418163-6 2016 Serum serotonin levels were positively correlated with weight, body mass index, whole body fat mass, leptin, and IGF-1, and negatively with CTX for the entire population. Serotonin 6-15 leptin Homo sapiens 101-107 35300211-7 2022 Results: Construction of short hairpin RNA (sh)-serotonin transporter (SERT) lentivirus vectors verified the regulation of the 5-HT signaling pathway by phosphorylated (p)-STAT/SERT. Serotonin 127-131 signal transducer and activator of transcription 3 Rattus norvegicus 172-176 26837719-6 2016 We found that serotonin and DOI (a selective agonist of 5-HT2A/C receptor) reversibly reduced GABA-activated currents, and this 5-HT2A/C receptor mediated inhibition required G protein, PLC, PKC, and Ca(2+) signaling. Serotonin 14-23 heparan sulfate proteoglycan 2 Homo sapiens 186-189 35300211-12 2022 Conclusion: This study highlights that SAHA treatment can alleviate D-IBS through regulation of the p-STAT3/SERT/5-HT signaling pathway. Serotonin 113-117 signal transducer and activator of transcription 3 Rattus norvegicus 102-107 26573960-0 2016 Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2/PTHrP/RANKL pathway in mice. Serotonin 12-21 runt related transcription factor 2 Mus musculus 95-100 34990844-3 2022 Of interest, preclinical studies point to serotonergic alterations, either induced via selective serotonin reuptake inhibitors or serotonin receptor (ant)agonists, in mitigating AD brain neuropathology next to its clinical symptoms, the latter being supported by a handful of human intervention trials. Serotonin 130-139 solute carrier family 25 member 6 Homo sapiens 150-153 26573960-0 2016 Gut-derived serotonin induced by depression promotes breast cancer bone metastasis through the RUNX2/PTHrP/RANKL pathway in mice. Serotonin 12-21 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 107-112 26560738-5 2016 As proof of concept, this methodology has been applied to selected ligands of the therapeutically relevant serotonin 5-HT1A and 5-HT6 receptors, and we have identified and validated some of their off-targets. Serotonin 107-116 5-hydroxytryptamine receptor 1A Homo sapiens 117-143 29567265-2 2019 Estrogen receptors, mainly ERbeta type, are commonly found in the dorsal raphe nucleus (DRN) neurons, an important nucleus related to anxiety modulation and the primary source of serotonin (5-HT) in the brain. Serotonin 179-188 estrogen receptor 2 Rattus norvegicus 27-33 33092667-5 2022 Alternatively, antidepressant pherines could facilitate the CRH and GABAergic neurons that inhibit the release of NPS from the LC, increase glutamate release from the BNST, and increase norepinephrine (NE), dopamine (DA), and serotonin release from the LC, VTA, and raphe nucleus, respectively. Serotonin 226-235 corticotropin releasing hormone Homo sapiens 60-63 31418663-6 2019 Although functional responses to serotonin are mediated via the activation of multiple receptor types and subtypes, the 5-HT1A subtype is involved in the processing of nociception as well as the pathogenesis and treatment of depression. Serotonin 33-42 5-hydroxytryptamine receptor 1A Homo sapiens 120-126 26721607-5 2016 Therefore the inhibition potential of MDMA and its metabolites on the deamination of the neurotransmitters DA and serotonin (5-HT) by MAO-A and B using recombinant human enzymes in vitro should be investigated. Serotonin 114-123 monoamine oxidase A Homo sapiens 134-139 2505676-2 1989 The experiments using phospholipase A2 or C inhibitor suggested that not only phospholipase C but also phospholipase A2 activity plays an important role in serotonin secretion. Serotonin 156-165 phospholipase A2 Oryctolagus cuniculus 22-38 27687599-6 2016 These data indicate that bone-marrow derived endothelial progenitors play a key role in the pathogenesis of PAH and suggest that interactions involving serotonin and bone morphogenic protein type 2 receptor (BMPR2) could take place at the level of the bone-marrow. Serotonin 152-161 bone morphogenetic protein receptor type 2 Homo sapiens 208-213 30565903-9 2019 Conclusion: These findings suggest that ERbeta alternative splicing and altered responses in the regulatory system for serotonin may mediate the antidepressant efficacy of ET associated with the timing of therapy initiation. Serotonin 119-128 estrogen receptor 2 Rattus norvegicus 40-46 30551684-7 2018 Using biochemical assays, melatonin, norepinephrine, acetylcholine and serotonin levels in the brain were found to be significantly reduced in lepa KO fish, while the levels of dopamine, glycine and cortisol in the brain were significantly elevated. Serotonin 71-80 leptin a Danio rerio 143-147 2505676-2 1989 The experiments using phospholipase A2 or C inhibitor suggested that not only phospholipase C but also phospholipase A2 activity plays an important role in serotonin secretion. Serotonin 156-165 phospholipase A2 Oryctolagus cuniculus 103-119 25975570-9 2016 The number of serotonin-positive fibers was significantly larger in the MNC and CD34 groups than in the vehicle group. Serotonin 14-23 CD34 antigen Mus musculus 80-84 2791236-9 1989 Thus, EDRF protects against contractions induced by histamine and serotonin in the mammary artery but not in the saphenous vein. Serotonin 66-75 alpha hemoglobin stabilizing protein Homo sapiens 6-10 2520772-3 1989 This report concerns specific binding sites for muramyl peptide in preparations of brain tissue, interaction between muramyl peptide and serotonin in binding to glial-derived cells, and the ability of both muramyl peptide and serotonin to induce release of interleukin-1-like activity from these cells. Serotonin 226-235 interleukin 1 alpha Homo sapiens 257-270 26578960-6 2015 In agreement with this hypothesis, serotonin depletion in the SUMn/PHn results in deficient spatial learning and alterations in CA1 theta activity-related learning in a Morris water maze. Serotonin 35-44 carbonic anhydrase 1 Rattus norvegicus 128-131 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 153-177 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 179-183 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 132-141 tryptophan hydroxylase 1 Homo sapiens 153-177 30351987-3 2018 We hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (TPH1)] would preserve maternal bone postweaning without affecting neonatal bone. Serotonin 132-141 tryptophan hydroxylase 1 Homo sapiens 179-183 26307562-9 2015 The activity of SOST and serotonin is either directly or indirectly associated with the canonical Wnt/beta-catenin signaling pathway, the main regulatory pathway of osteoblasts function. Serotonin 25-34 catenin beta 1 Homo sapiens 102-114 2520772-8 1989 We found that low-nanomolar concentrations of either muramyl peptide or serotonin rapidly induced release of interleukin-1-like activity from a glial cell line. Serotonin 72-81 interleukin 1 alpha Homo sapiens 109-122 2538842-2 1989 Using two-dimensional PAGE, we found that exposure to serotonin (5-hydroxytryptamine, 5-HT) for 2 or 3 hr appeared to increase incorporation of labeled amino acids into one protein (P9) and decrease incorporation into two other proteins (P19 and P20). Serotonin 54-63 interleukin 23 subunit alpha Homo sapiens 238-249 26335661-4 2015 Metformin inhibited histamine and serotonin uptake by OCT1, OCT3 and SERT in a dose-dependent manner, with OCT1-mediated amine uptake being most potently inhibited (IC50 = 1.5 mM). Serotonin 34-43 POU class 5 homeobox 1 Homo sapiens 60-64 2538842-2 1989 Using two-dimensional PAGE, we found that exposure to serotonin (5-hydroxytryptamine, 5-HT) for 2 or 3 hr appeared to increase incorporation of labeled amino acids into one protein (P9) and decrease incorporation into two other proteins (P19 and P20). Serotonin 65-84 interleukin 23 subunit alpha Homo sapiens 238-249 30256659-1 2018 ATP-binding cassette, subfamily B, member 1 (ABCB1) transport, or P-glycoprotein (P-gp), is a transport protein that is involved in the absorption and the efflux of some antidepressants, such as selective serotonin reuptake inhibitors. Serotonin 205-214 ATP-binding cassette, sub-family B (MDR/TAP), member 1 Sus scrofa 0-43 2538842-2 1989 Using two-dimensional PAGE, we found that exposure to serotonin (5-hydroxytryptamine, 5-HT) for 2 or 3 hr appeared to increase incorporation of labeled amino acids into one protein (P9) and decrease incorporation into two other proteins (P19 and P20). Serotonin 86-90 interleukin 23 subunit alpha Homo sapiens 238-249 30256659-1 2018 ATP-binding cassette, subfamily B, member 1 (ABCB1) transport, or P-glycoprotein (P-gp), is a transport protein that is involved in the absorption and the efflux of some antidepressants, such as selective serotonin reuptake inhibitors. Serotonin 205-214 ATP-binding cassette, sub-family B (MDR/TAP), member 1 Sus scrofa 45-50 26238767-1 2015 Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which is the rate-limiting enzyme in serotonin synthesis. Serotonin 205-214 tryptophan hydroxylase 1 Homo sapiens 135-159 2566254-4 1989 We also present data on the CSF metabolites dopamine, norepinephrine and serotonin of one patient. Serotonin 73-82 colony stimulating factor 2 Homo sapiens 28-31 26238767-1 2015 Decoy receptor 3 (DcR3) is expressed in rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) and downregulates the expression of tryptophan hydroxylase 1 (TPH1), which is the rate-limiting enzyme in serotonin synthesis. Serotonin 205-214 tryptophan hydroxylase 1 Homo sapiens 161-165 26442099-0 2015 Aging and chronic administration of serotonin-selective reuptake inhibitor citalopram upregulate Sirt4 gene expression in the preoptic area of male mice. Serotonin 36-45 sirtuin 4 Mus musculus 97-102 28761080-0 2018 Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor-dependent manner. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 58-73 2924086-4 1989 The results demonstrated the presence of MAO A and B in human thyroid cells which oxidized 5-hydroxytryptamine and 2-phenylethylamine, respectively, and were selectively inhibited by the MAO inhibitors clorgyline and (-)-deprenyl. Serotonin 91-110 monoamine oxidase A Homo sapiens 41-52 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Serotonin 107-116 monoamine oxidase A Homo sapiens 0-19 30271325-1 2018 Monoamine oxidase A (MAO-A) is an enzyme that regulates the levels of monoamine neurotransmitters, such as serotonin, noradrenaline and dopamine and it has been used as a therapeutic target for depression. Serotonin 107-116 monoamine oxidase A Homo sapiens 21-26 26086546-0 2015 Androgen metabolites impact CSF amines and axonal serotonin via MAO-A and -B in male macaques. Serotonin 50-59 monoamine oxidase A Homo sapiens 64-69 2525178-4 1989 In cortical membranes 3H-serotonin bound to a heterogeneous population of sites, one of which was similar to a binding site labelled by 3H-DPAT (the putative 5HT-1A receptor). Serotonin 25-34 5-hydroxytryptamine receptor 1A Homo sapiens 158-173 26086546-1 2015 A number of studies have shown that mutations or deletions of the monoamine oxidase-A (MAO-A) gene cause elevated CNS serotonin and elevated impulsive aggression in humans and animal models. Serotonin 118-127 monoamine oxidase A Homo sapiens 66-85 26086546-1 2015 A number of studies have shown that mutations or deletions of the monoamine oxidase-A (MAO-A) gene cause elevated CNS serotonin and elevated impulsive aggression in humans and animal models. Serotonin 118-127 monoamine oxidase A Homo sapiens 87-92 26086546-3 2015 To reconcile these different analyses, we hypothesized that CSF 5HIAA reflected degradation of serotonin by the activity of MAO-A; and that low MAO-A activity would result in lower CSF 5HIAA, but overall higher serotonin in the CNS. Serotonin 211-220 monoamine oxidase A Homo sapiens 144-149 26086546-15 2015 Androgens lower MAO-A activity via metabolism to E, thus elevating CNS serotonin and decreasing CSF 5HIAA. Serotonin 71-80 monoamine oxidase A Homo sapiens 16-21 26086546-16 2015 Since androgens increase certain types of aggression, these data are consistent with studies demonstrating that lower MAO-A activity is associated with elevated serotonin and increased aggression. Serotonin 161-170 monoamine oxidase A Homo sapiens 118-123 30036531-2 2018 In healthy subjects, dopamine D2/D3 receptor availability particularly in the striatum and serotonin 5-HT1A and 5-HT2A receptor availabilities in the cortex predict the subject"s response to tonic experimental pain. Serotonin 91-100 5-hydroxytryptamine receptor 1A Homo sapiens 101-113 30036531-8 2018 These findings suggest that dopamine acting on striatal dopamine D2/D3 receptors and serotonin acting on cortical 5-HT1A and 5-HT2A receptors contribute to top-down pain regulation in humans. Serotonin 85-94 5-hydroxytryptamine receptor 1A Homo sapiens 114-126 30037999-0 2018 A population of gut epithelial enterochromaffin cells is mechanosensitive and requires Piezo2 to convert force into serotonin release. Serotonin 116-125 piezo-type mechanosensitive ion channel component 2 Mus musculus 87-93 30037999-8 2018 In these mechanosensitive EE cells force leads to Piezo2-dependent intracellular Ca2+ increase in isolated cells as well as in EE cells within intestinal organoids, and Piezo2-dependent mechanosensitive serotonin release in EC cells. Serotonin 203-212 piezo-type mechanosensitive ion channel component 2 Mus musculus 169-175 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Serotonin 230-239 C-C motif chemokine ligand 2 Homo sapiens 25-31 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Serotonin 230-239 C-C motif chemokine ligand 2 Homo sapiens 31-35 2536429-2 1989 K+-evoked outflow of serotonin was inhibited significantly up to 50% in the presence of the mu-selective agonist [D-Ala2,N-methyl-Phe4,Gly5-ol]enkephalin (DAGO) and of the delta-selective agonist [D-Pen2,D-Pen5]enkephalin (DPDPE). Serotonin 21-30 proenkephalin Rattus norvegicus 143-153 25912293-9 2015 These genes encode for elements involved in circadian rhythm regulation (RBM3 and NR1D1) and in serotonin synthesis (TPH1), processes previously involved in both disorders, and in the mechanism of action of lithium. Serotonin 96-105 tryptophan hydroxylase 1 Homo sapiens 117-121 29874909-0 2018 Noncaloric Sweeteners Induce Peripheral Serotonin Secretion via the T1R3-Dependent Pathway in Human Gastric Parietal Tumor Cells (HGT-1). Serotonin 40-49 solute carrier family 25 member 16 Homo sapiens 130-135 2536429-2 1989 K+-evoked outflow of serotonin was inhibited significantly up to 50% in the presence of the mu-selective agonist [D-Ala2,N-methyl-Phe4,Gly5-ol]enkephalin (DAGO) and of the delta-selective agonist [D-Pen2,D-Pen5]enkephalin (DPDPE). Serotonin 21-30 proenkephalin Rattus norvegicus 211-221 25732261-15 2015 IHC demonstrated microgliosis in and around the injection site and mHTT-positive inclusions in serotonin-producing neurons and a small percentage of astrocytes in animals injected with N171-82Q compared to controls. Serotonin 95-104 huntingtin Mus musculus 67-71 2473413-3 1989 Substance P-like immunoreactivity is first co-localized with serotonin in cells of the caudal medullary raphe (raphe pallidus and raphe obscurus) at embryonic day 13. Serotonin 61-70 tachykinin 1 Mus musculus 0-11 2473413-9 1989 Unexpectedly, we found that neurons containing substance P-like immunoreactivity in the piriform cortex and in the hypothalamus transiently expressed serotonin immunoreactivity during normal ontogenesis. Serotonin 150-159 tachykinin 1 Mus musculus 47-58 25673289-9 2015 These SgIII-expressing cells co-expressed serotonin, somatostatin, gastric inhibitory polypeptide, glucagon-like peptide-1, glucagon, or insulin. Serotonin 42-51 secretogranin III Gallus gallus 6-11 3142274-1 1988 Experiments were designed to determine the role of products of cyclooxygenase in contractions of coronary smooth muscle evoked by serotonin. Serotonin 130-139 prostaglandin-endoperoxide synthase 1 Canis lupus familiaris 63-77 25652393-10 2015 This finding suggests that the interaction between two major serotonergic structures involved in serotonin release, specifically the SERT and 5-HT1B receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-HT1A receptors. Serotonin 97-106 5-hydroxytryptamine receptor 1A Homo sapiens 234-240 29550938-1 2018 Serotonin 1A (5-HT1A) receptors mediate serotonin trophic role in brain neurogenesis. Serotonin 40-49 5-hydroxytryptamine receptor 1A Homo sapiens 14-20 3390156-4 1988 Furthermore, platelet aggregation and 5-hydroxytryptamine release induced by cell-free supernatants from fMet-Leu-Phe-stimulated neutrophils were found to be blocked by antiserum to cathepsin G in a concentration-dependent manner but were unaffected by antiserum to elastase. Serotonin 40-57 cathepsin G Homo sapiens 182-193 29867758-7 2018 The habenular Kiss1 is involved in the modulation of the raphe nuclei and serotonin-related behaviors such as fear response in the zebrafish. Serotonin 74-83 KiSS-1 metastasis suppressor Danio rerio 14-19 25897671-3 2015 The aim of this study was to investigate levels of serotonin in patients with the autoimmune disease systemic lupus erythematosus (SLE), association to clinical phenotype and possible involvement of IDO in regulation of serotonin synthesis. Serotonin 220-229 indoleamine 2,3-dioxygenase 1 Homo sapiens 199-202 25897671-11 2015 Further, our data suggest that type I IFNs, present in SLE sera, are able to up-regulate IDO expression, which may lead to decreased serum serotonin levels. Serotonin 139-148 indoleamine 2,3-dioxygenase 1 Homo sapiens 89-92 3390156-7 1988 Purified cathepsin G from neutrophils cross-reacted with anti-(cathepsin G) serum in a double immunodiffusion assay and elicited platelet calcium mobilization, 5-hydroxytryptamine secretion and aggregation. Serotonin 160-179 cathepsin G Homo sapiens 9-20 29292133-2 2018 5-HT1A autoreceptors in the raphe control serotonin release by means of negative feedback inhibition. Serotonin 42-51 5-hydroxytryptamine receptor 1A Homo sapiens 0-6 2453262-6 1988 T-2 toxin treatment resulted in increased serotonin and 5-hydroxy-3-indoleacetic acid in all brain regions of the rat. Serotonin 42-51 brachyury 2 Rattus norvegicus 0-3 29381782-12 2018 We conclude that serotonin is conveyed from the maternal blood stream through syncytiotrophoblasts, cytotrophoblasts and the villus core to the fetus through a physiological pathway that involves at least SERT, gap junctions, P-gp, OCT3, and MAOA. Serotonin 17-26 phosphoglycolate phosphatase Homo sapiens 226-230 25856052-3 2015 In recent years, there has been a dramatic improvement in the control of CINV with the introduction of effective antiemetic agents, including the serotonin (5-hydroxytryptamine [5-HT3]) receptor antagonists (ondansetron, granisetron, and palonosetron) and the neurokinin-1 (NK1) receptor antagonists (aprepitant and fosaprepitant). Serotonin 146-155 tachykinin receptor 1 Homo sapiens 260-287 29381782-12 2018 We conclude that serotonin is conveyed from the maternal blood stream through syncytiotrophoblasts, cytotrophoblasts and the villus core to the fetus through a physiological pathway that involves at least SERT, gap junctions, P-gp, OCT3, and MAOA. Serotonin 17-26 monoamine oxidase A Homo sapiens 242-246 2897354-5 1988 Administration of T-2 toxin caused increases in brain concentrations of tryptophan and serotonin at the early time intervals after dosing. Serotonin 87-96 brachyury 2 Rattus norvegicus 18-21 25288485-7 2015 This study suggests that serotonin signaling through postsynaptic 5-HT1A receptors in the hippocampus is critical for the antidepressant-like effects of a cholinergic drug and begins to elucidate the molecular mechanisms underlying interactions between the serotonergic and cholinergic systems related to mood disorders. Serotonin 25-34 5-hydroxytryptamine receptor 1A Homo sapiens 66-72 2854052-7 1988 Serotonin, histamine, and angiotensin II produced higher levels of inositol phosphates (IP, IP2, IP3) in SMC than in endothelium. Serotonin 0-9 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 92-95 25429115-3 2015 Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels are the molecular correlate of the hyperpolarization-activated inward current (Ih) and have a high propensity for modulation by serotonin. Serotonin 195-204 cyclic nucleotide gated channel subunit alpha 1 Rattus norvegicus 53-56 26881178-6 2015 In agreement, clinical investigations have shown that grafted tissue may contain a large number of serotonin neurons, in the order of half of the DA cells; moreover, the serotonin 5-HT1A receptor agonist buspirone has been found to produce significant dampening of GID in grafted patients. Serotonin 99-108 5-hydroxytryptamine receptor 1A Homo sapiens 180-195 29523295-6 2018 Furthermore, SNORD115 genes may underlie a genetic vulnerability when environmental triggers result in excess serotonin producing the serotonin syndrome, a condition similar to NMS in which catatonia may occur. Serotonin 110-119 small nucleolar RNA, C/D box 115 cluster Homo sapiens 13-21 2952898-1 1987 The present study was designed to investigate the effect of distinct serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Serotonin 69-78 5-hydroxytryptamine receptor 1A Homo sapiens 80-86 3791042-5 1986 The results of this study suggest that CA1 hippocampus is another structure, innervated by serotonergic neurones, where all (peripherally active) serotonin antagonists tested to date are ineffective against 5-hydroxytryptamine induced inhibition. Serotonin 146-155 carbonic anhydrase 1 Rattus norvegicus 39-42 29266595-0 2018 Differential modulation of CA1 impulse flow by endogenous serotonin along the hippocampal longitudinal axis. Serotonin 58-67 carbonic anhydrase 1 Rattus norvegicus 27-30 3778827-0 1986 Alloantibody-induced platelet serotonin release is blocked by antibody to the platelet PLA1 antigen. Serotonin 30-39 POU class 2 homeobox 3 Homo sapiens 87-91 2420928-1 1986 Monoamine oxidase (MAO) type A and type B were measured using kynuramine, 3,4-dihydroxyphenylethylamine (dopamine, DA), and 5-hydroxytryptamine (5-HT, serotonin) in 20 brain areas. Serotonin 124-143 monoamine oxidase A Homo sapiens 0-41 29456827-9 2018 Moreover, neurotransmitters including serotonin, norepinephrine, and dopamine were significantly increased in different brain regions of the Arhgef10 knockout mice. Serotonin 38-47 Rho guanine nucleotide exchange factor (GEF) 10 Mus musculus 141-149 2420928-1 1986 Monoamine oxidase (MAO) type A and type B were measured using kynuramine, 3,4-dihydroxyphenylethylamine (dopamine, DA), and 5-hydroxytryptamine (5-HT, serotonin) in 20 brain areas. Serotonin 145-149 monoamine oxidase A Homo sapiens 0-41 2420928-1 1986 Monoamine oxidase (MAO) type A and type B were measured using kynuramine, 3,4-dihydroxyphenylethylamine (dopamine, DA), and 5-hydroxytryptamine (5-HT, serotonin) in 20 brain areas. Serotonin 151-160 monoamine oxidase A Homo sapiens 0-41 3838100-1 1985 Serotonin N-acetyltransferase, an enzyme of the pineal gland, converts serotonin to N-acetylserotonin. Serotonin 71-80 aralkylamine N-acetyltransferase Rattus norvegicus 0-29 29194046-7 2018 SUMMARY: The gastrointestinal tract is the largest storage organ for serotonin where its biosynthesis is regulated by TPH1. Serotonin 69-78 tryptophan hydroxylase 1 Homo sapiens 118-122 2582215-2 1985 This article reviews the relationship between the turnover of the neurotransmitter monoamines noradrenaline, serotonin, and dopamine, and the concentrations in CSF of their principal metabolites, 3-methoxy-4-hydroxyphenylglycol (MHPG), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA). Serotonin 109-118 colony stimulating factor 2 Homo sapiens 160-163 29291611-12 2018 Further analysis via real-time polymerase chain reaction suggested that IBS patient-derived RNA exhibited lower levels of tryptophan hydroxylase-1 expression, the enzyme that catalyzes the rate-limiting step in serotonin biosynthesis. Serotonin 211-220 tryptophan hydroxylase 1 Homo sapiens 122-146 29225192-8 2018 Besides binding to transporters, diphenidine bound to adrenergic alpha1A and alpha2A receptors and serotonin 5-hydroxytryptamine 1A (5-HT1A) and 5-HT2A receptors in the range of 4-11muM. Serotonin 99-108 5-hydroxytryptamine receptor 1A Homo sapiens 133-139 6238960-0 1984 Serotonin secretion from human platelets may be modified by Ca2+-activated, phospholipid-dependent myosin phosphorylation. Serotonin 0-9 myosin heavy chain 14 Homo sapiens 99-105 29241538-4 2017 We identified elc-2, an Elongin C ortholog, specifically expressed in stress-sensing amphid neuron dual ciliated sensory ending (ADF) serotonergic sensory neurons, and we found that it plays a role in mediating a long-lasting change in serotonin-dependent feeding behavior induced by heat stress. Serotonin 236-245 Elongin-C Caenorhabditis elegans 24-33 6209991-1 1984 CSF concentrations of serotonin and dopamine metabolites in 16 patients with anorexia nervosa were measured before and after probenecid administration, and the patients were studied before and at intervals after weight recovery. Serotonin 22-31 colony stimulating factor 2 Homo sapiens 0-3 29156899-8 2017 In addition, their results suggest that anti-allodynic effects may also be mediated by additional receptors, including TRPV1 and 5-hydroxytryptamine (5-HT1A). Serotonin 129-148 5-hydroxytryptamine receptor 1A Homo sapiens 150-156 6209595-3 1984 Premortem CSF levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels were elevated. Serotonin 24-43 colony stimulating factor 2 Homo sapiens 10-13 6209595-3 1984 Premortem CSF levels of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) levels were elevated. Serotonin 45-49 colony stimulating factor 2 Homo sapiens 10-13 29066557-7 2017 These Nmb-low RTN neurons also express varying levels of transcripts for Gal, Penk, and Adcyap1, and receptors for substance P, orexin, serotonin, and ATP. Serotonin 136-145 neuromedin B Mus musculus 6-9 6386102-0 1984 Enkephalin-like immunoreactivity in rat area postrema: ultrastructural localization and coexistence with serotonin. Serotonin 105-114 proenkephalin Rattus norvegicus 0-10 29035515-3 2017 TPH1 catalyzes the initial step in the synthesis of serotonin in the peripheral tissues, while TPH2 catalyzes this step in the brain. Serotonin 52-61 tryptophan hydroxylase 1 Homo sapiens 0-4 6386102-1 1984 The ultrastructure of enkephalin-containing neurons and their capacity to take-up [3H]serotonin were examined in the area postrema. Serotonin 86-95 proenkephalin Rattus norvegicus 22-32 6386102-11 1984 We conclude that neurons containing ELI are primarily, but not exclusively, associated with other intrinsic neurons or afferents in the rat area postrema and that some of the enkephalin-labeled terminals have the capacity to take-up serotonin. Serotonin 233-242 proenkephalin Rattus norvegicus 175-185 6477519-6 1984 In permeabilized platelets, as in the intact cells, release of serotonin was associated with the Ca2+-dependent phosphorylation of 47 000 and 20 000 Da polypeptides (P47 and P20). Serotonin 63-72 pleckstrin Homo sapiens 166-169 28864211-12 2017 However, deletion of SPAK not only reduced the elevation of NO levels but also improved vascular hyporeactivity to serotonin and PE in endotoxemic mice. Serotonin 115-124 serine/threonine kinase 39 Mus musculus 21-25 6431801-2 1984 Irreversible aggregation and 14C-serotonin secretion in response to PAF (10(-5) M) was found to be dependent on both thromboxane production and secreted adenosine diphosphate (ADP). Serotonin 33-42 PCNA clamp associated factor Homo sapiens 68-71 28845660-0 2017 Medium-Throughput Screen of Microbially Produced Serotonin via a G-Protein-Coupled Receptor-Based Sensor. Serotonin 49-58 C-X-C motif chemokine receptor 6 Homo sapiens 65-91 28845660-2 2017 Here, we engineer a G-protein-coupled receptor (GPCR)-based sensor to detect serotonin produced by a producer microbe in the producer microbe"s supernatant. Serotonin 77-86 C-X-C motif chemokine receptor 6 Homo sapiens 20-46 28845660-2 2017 Here, we engineer a G-protein-coupled receptor (GPCR)-based sensor to detect serotonin produced by a producer microbe in the producer microbe"s supernatant. Serotonin 77-86 C-X-C motif chemokine receptor 6 Homo sapiens 48-52 6206589-0 1984 Inhibition of thrombin-induced platelet aggregation and serotonin release by antithrombin III and heparin cofactor II in the presence of standard heparin, dermatan sulfate and pentosan polysulfate. Serotonin 56-65 serpin family C member 1 Homo sapiens 77-93 6320925-0 1984 Effect of polyethyleneglycols (PEG 600 and PEG 6000) and bovine serum albumin on myeloperoxidase-mediated release of [3H]-serotonin from rat peritoneal mast cells in vitro. Serotonin 122-131 myeloperoxidase Rattus norvegicus 81-96 6320925-1 1984 Rat peritoneal mast cells in vitro released [3H]-serotonin in the presence of halide (I-), myeloperoxidase (MPO), and a H2O2-generating system. Serotonin 49-58 myeloperoxidase Rattus norvegicus 91-106 29042483-3 2017 Experience-mediated enhancement of chaperone gene expression required serotonin, which primed HSF-1 to enhance the expression of molecular chaperone genes by promoting its localization to RNA polymerase II-enriched nuclear loci, even before transcription occurred. Serotonin 70-79 Heat shock transcription factor hsf-1 Caenorhabditis elegans 94-99 6320925-1 1984 Rat peritoneal mast cells in vitro released [3H]-serotonin in the presence of halide (I-), myeloperoxidase (MPO), and a H2O2-generating system. Serotonin 49-58 myeloperoxidase Rattus norvegicus 108-111 6089242-1 1984 Stimulation of GABA receptors (e.g. by progabide, a new GABA receptor antagonist, or by muscimol) enhances the liberation of norepinephrine in limbic forebrain areas of the rat and reduces 5-hydroxytryptamine turnover. Serotonin 189-208 GABA type A receptor-associated protein Homo sapiens 15-28 27641077-7 2017 The uptake of MPP+, serotonin and dopamine by MDCK/hPMAT, MDCK/rPmat and Flp293/mPmat cells was significantly increased compared with those by the mock transfection control. Serotonin 20-29 solute carrier family 29 member 4 Homo sapiens 51-56 27641077-9 2017 The hPMAT-, rPmat- and mPmat-mediated uptakes of MPP+, serotonin and dopamine were saturable, with Km values of 33.7muM, 70.2muM and 49.5muM (MPP+), 116muM, 82.9muM and 231muM (serotonin), and 201muM, 271muM and 466muM (dopamine), respectively, suggesting similar substrate affinities between human and rodent PMAT/Pmat. Serotonin 55-64 solute carrier family 29 member 4 Homo sapiens 4-9 25003645-2 2014 Although AIH-induced phrenic LTF is serotonin dependent, adenosine constrained in anesthetized rats, this has not been tested in unanesthetized animals. Serotonin 36-45 lactotransferrin Rattus norvegicus 29-32 6198594-0 1983 Behavioural responses induced by intrathecal injection of 5-hydroxytryptamine in mice are inhibited by a substance P antagonist, D-Pro2, D-Trp7,9-substance P. Serotonin 58-77 tachykinin 1 Mus musculus 105-116 24356376-1 2014 Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Serotonin 123-132 monoamine oxidase A Homo sapiens 21-40 24356376-1 2014 Expression levels of monoamine oxidase A (MAOA), the enzyme that related to monoamine neurotransmitters metabolism such as serotonin, are related to schizophrenia and autism spectrum disorder. Serotonin 123-132 monoamine oxidase A Homo sapiens 42-46 24356376-2 2014 Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development and is expressed in several areas of the central nervous system in response to serotonin. Serotonin 185-194 forkhead box P2 Homo sapiens 0-23 27641077-9 2017 The hPMAT-, rPmat- and mPmat-mediated uptakes of MPP+, serotonin and dopamine were saturable, with Km values of 33.7muM, 70.2muM and 49.5muM (MPP+), 116muM, 82.9muM and 231muM (serotonin), and 201muM, 271muM and 466muM (dopamine), respectively, suggesting similar substrate affinities between human and rodent PMAT/Pmat. Serotonin 55-64 solute carrier family 29 member 4 Homo sapiens 5-9 27641077-9 2017 The hPMAT-, rPmat- and mPmat-mediated uptakes of MPP+, serotonin and dopamine were saturable, with Km values of 33.7muM, 70.2muM and 49.5muM (MPP+), 116muM, 82.9muM and 231muM (serotonin), and 201muM, 271muM and 466muM (dopamine), respectively, suggesting similar substrate affinities between human and rodent PMAT/Pmat. Serotonin 55-64 solute carrier family 29 member 4 Homo sapiens 13-17 27641077-9 2017 The hPMAT-, rPmat- and mPmat-mediated uptakes of MPP+, serotonin and dopamine were saturable, with Km values of 33.7muM, 70.2muM and 49.5muM (MPP+), 116muM, 82.9muM and 231muM (serotonin), and 201muM, 271muM and 466muM (dopamine), respectively, suggesting similar substrate affinities between human and rodent PMAT/Pmat. Serotonin 177-186 solute carrier family 29 member 4 Homo sapiens 4-9 27641077-9 2017 The hPMAT-, rPmat- and mPmat-mediated uptakes of MPP+, serotonin and dopamine were saturable, with Km values of 33.7muM, 70.2muM and 49.5muM (MPP+), 116muM, 82.9muM and 231muM (serotonin), and 201muM, 271muM and 466muM (dopamine), respectively, suggesting similar substrate affinities between human and rodent PMAT/Pmat. Serotonin 177-186 solute carrier family 29 member 4 Homo sapiens 5-9 27641077-9 2017 The hPMAT-, rPmat- and mPmat-mediated uptakes of MPP+, serotonin and dopamine were saturable, with Km values of 33.7muM, 70.2muM and 49.5muM (MPP+), 116muM, 82.9muM and 231muM (serotonin), and 201muM, 271muM and 466muM (dopamine), respectively, suggesting similar substrate affinities between human and rodent PMAT/Pmat. Serotonin 177-186 solute carrier family 29 member 4 Homo sapiens 13-17 24356376-2 2014 Forkhead box protein P2 (FOXP2), a transcription factor, is associated with abnormal language development and is expressed in several areas of the central nervous system in response to serotonin. Serotonin 185-194 forkhead box P2 Homo sapiens 25-30 6198594-0 1983 Behavioural responses induced by intrathecal injection of 5-hydroxytryptamine in mice are inhibited by a substance P antagonist, D-Pro2, D-Trp7,9-substance P. Serotonin 58-77 tachykinin 1 Mus musculus 146-157 6365248-6 1983 Serotonin blocked the behavioral effect of LHRH infusion into the ARC-VM, but did not prevent enhancement of lordosis by LHRH infusions into the VL-MCG. Serotonin 0-9 gonadotropin releasing hormone 1 Rattus norvegicus 43-47 25281790-1 2014 The role of the serotonergic system in regulating the expression of estrogen receptor (ER) alpha in the hypothalamus was investigated in ovariectomized rats by injecting a serotonin synthesis inhibitor, parachlorophenylalanine (PCPA), or by destroying the dorsal raphe nucleus (DR). Serotonin 172-181 estrogen receptor 1 Rattus norvegicus 68-96 28242245-0 2017 Inhibition of neuronal mitochondrial complex I or lysosomal glucocerebrosidase is associated with increased dopamine and serotonin turnover. Serotonin 121-130 glucosylceramidase beta Homo sapiens 50-78 6408754-3 1983 During PAF-induced irreversible aggregation a 9 to 40% release of platelet bound serotonin occurred. Serotonin 81-90 PCNA clamp associated factor Homo sapiens 7-10 28899417-3 2017 Serotonin (5-HT) augmentation therapy by treatment with selective serotonin reuptake inhibitors (SSRIs) in patients with AD has had mixed success in improving cognitive function, whereas SSRI administration to mice with AD-like disease has been shown to reduce Abeta pathology. Serotonin 0-9 amyloid beta (A4) precursor protein Mus musculus 261-266 28899417-3 2017 Serotonin (5-HT) augmentation therapy by treatment with selective serotonin reuptake inhibitors (SSRIs) in patients with AD has had mixed success in improving cognitive function, whereas SSRI administration to mice with AD-like disease has been shown to reduce Abeta pathology. Serotonin 11-15 amyloid beta (A4) precursor protein Mus musculus 261-266 28899417-4 2017 The objective of this study was to investigate whether an increase in extracellular levels of 5-HT induced by chronic SSRI treatment reduces Abeta pathology and whether 5-HTergic deafferentation of the cerebral cortex could worsen Abeta pathology in the APPswe/PS1DeltaE9 (APP/PS1) mouse model of AD. Serotonin 94-98 amyloid beta (A4) precursor protein Mus musculus 141-146 28899417-13 2017 CONCLUSIONS: Because this study shows that modulation of the 5-HTergic system has either no effect or increases levels of insoluble/soluble Abeta42 and Abeta40 in the cerebral cortex of APP/PS1 mice, our observations do not support 5-HT augmentation therapy as a preventive strategy for reducing Abeta pathology. Serotonin 61-65 presenilin 1 Mus musculus 190-193 25066466-6 2014 IFN-alpha stimulates indoleamine-2,3 dioxygenase-1, activating the kynurenine pathway with reduced formation of the neurotransmitters serotonin and dopamine, excessive formation of the NMDA agonist quinolinic acid, and reduced formation of the NMDA antagonist kynurenic acid. Serotonin 134-143 indoleamine 2,3-dioxygenase 1 Homo sapiens 21-50 24468700-0 2014 Overexpression of gastric leptin precedes adipocyte leptin during high-fat diet and is linked to 5HT-containing enterochromaffin cells. Serotonin 97-100 leptin Mus musculus 26-32 24468700-7 2014 Finally, mice with an intestine-specific deletion of leptin signaling exhibit significant decrease in duodenal mucosa 5HT content. Serotonin 118-121 leptin Mus musculus 53-59 6408754-4 1983 The specific effect of PAF, however, seems to be limited to induce reversible aggregation since second wave of aggregation and serotonin release were suppressed by a combination of acetylsalicylic acid and an ADP scavenging system. Serotonin 127-136 PCNA clamp associated factor Homo sapiens 23-26 24468700-9 2014 RESULTS from high-fat diet mice showed that overexpression of gastric leptin that is linked to gut "5HT pathway" occurred before the onset of obesity and expansion of fat mass. Serotonin 100-103 leptin Mus musculus 70-76 6295736-1 1982 Serotonin is involved in the control of ACTH secretion, possibly by stimulating corticotropin releasing factor secretion from the hypothalamus. Serotonin 0-9 corticotropin releasing hormone Homo sapiens 80-110 25157819-3 2014 Estrogen-dependent inhibition of binge-like eating was blocked in female mice specifically lacking estrogen receptor-alpha (ERalpha) in serotonin (5-HT) neurons in the dorsal raphe nuclei (DRN). Serotonin 136-145 estrogen receptor 1 (alpha) Mus musculus 99-122 28554847-2 2017 Studies with drugs that interfere with serotonin-mediated neurotransmission suggest that the mu-opioid receptor (MOR) synergistically interacts with the 5-HT1A receptor in the dPAG to inhibit escape, a panic-related behavior. Serotonin 39-48 opioid receptor mu 1 Homo sapiens 93-111 28554847-2 2017 Studies with drugs that interfere with serotonin-mediated neurotransmission suggest that the mu-opioid receptor (MOR) synergistically interacts with the 5-HT1A receptor in the dPAG to inhibit escape, a panic-related behavior. Serotonin 39-48 opioid receptor mu 1 Homo sapiens 113-116 28554847-2 2017 Studies with drugs that interfere with serotonin-mediated neurotransmission suggest that the mu-opioid receptor (MOR) synergistically interacts with the 5-HT1A receptor in the dPAG to inhibit escape, a panic-related behavior. Serotonin 39-48 5-hydroxytryptamine receptor 1A Homo sapiens 153-168 7064189-0 1982 CSF serotonin concentrations and cerebral arterial spasm in patients with ruptured intracranial aneurysm. Serotonin 4-13 colony stimulating factor 2 Homo sapiens 0-3 28655495-4 2017 Serotonin, norepinephrine, dopamine, and trace amines, such as the "endogenous amphetamine" phenylethylamine, are increased in brain, which leads to changes in neuroplasticity by e.g. increased neurotrophic growth factors and translates to reduced stress-induced hypersecretion of corticotropin releasing factor (CRF) and positive testing in animal studies of depression. Serotonin 0-9 corticotropin releasing hormone Homo sapiens 281-311 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 89-98 monoamine oxidase A Homo sapiens 0-19 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 89-98 monoamine oxidase A Homo sapiens 21-26 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 100-119 monoamine oxidase A Homo sapiens 0-19 28962277-1 2014 Monoamine oxidase-A (MAO-A) is the main enzyme in the metabolism of the neurotransmitter serotonin (5-hydroxytryptamine). Serotonin 100-119 monoamine oxidase A Homo sapiens 21-26 7064189-1 1982 In 26 patients with recent rupture of an intracranial saccular aneurysm the CSF concentrations of serotonin (5-HT) were measured repeatedly by a radioimmunoassay. Serotonin 98-107 colony stimulating factor 2 Homo sapiens 76-79 28377303-2 2017 The central inhibition of MAO-A by MB has also been linked to serotonin toxicity (ST) which may arise when MB is used in combination with serotonergic drugs. Serotonin 62-71 monoamine oxidase A Homo sapiens 26-31 6120986-6 1982 Serotonin stimulated release of prolactin and inhibited release of growth hormone from pituitary-hypothalamus co-incubations, and these effects were blocked by its antagonist, methysergide. Serotonin 0-9 prolactin Columba livia 32-41 28418735-8 2017 Patients with parkinsonism with MAO-A TT genotype have a significantly higher level of 5-HT [5-HT (II), p < 0.05] compared to controls. Serotonin 87-91 monoamine oxidase A Homo sapiens 32-37 28418735-8 2017 Patients with parkinsonism with MAO-A TT genotype have a significantly higher level of 5-HT [5-HT (II), p < 0.05] compared to controls. Serotonin 93-97 monoamine oxidase A Homo sapiens 32-37 25040027-7 2014 For example, although serotonin (5-HT) has a stimulatory effect on the HPA axis in humans and rodents that is mediated by the 5-HT1A receptor, only male rodents respond to 5-HT1A antagonism to show increased corticosterone responses to stress. Serotonin 22-31 5-hydroxytryptamine receptor 1A Homo sapiens 126-141 25040027-7 2014 For example, although serotonin (5-HT) has a stimulatory effect on the HPA axis in humans and rodents that is mediated by the 5-HT1A receptor, only male rodents respond to 5-HT1A antagonism to show increased corticosterone responses to stress. Serotonin 22-31 5-hydroxytryptamine receptor 1A Homo sapiens 126-132 24657329-7 2014 All of the nine antidepressant compounds showed moderate inhibitory effects on OCT2-mediated metformin, serotonin and/or norepinephrine uptake. Serotonin 104-113 solute carrier family 22 member 2 Homo sapiens 79-83 6120986-9 1982 These results indicate that the neurotransmitters, dopamine and serotonin, affect the in-vitro release of factors from the hypothalamus which control the secretion of prolactin and growth hormone. Serotonin 64-73 prolactin Columba livia 167-176 28375615-4 2017 We demonstrate that the MET receptor tyrosine kinase (MET) is specifically expressed in a subset of 5-HT neurons within the caudal part of the dorsal raphe nuclei (DRC) that is encompassed by the classic B6 serotonin cell group. Serotonin 207-216 ret proto-oncogene Homo sapiens 28-52 7227455-1 1981 SKF 64139, a potent inhibitor of adrenal and brain phenylethanolamine-N-methyltransferase (PNMT), was found to have effects on catecholamines, serotonin and their metabolites in rat brain which suggest it may act as a potent inhibitor of monoamine oxidase (MAO) "in vivo" after acute administration. Serotonin 143-152 phenylethanolamine-N-methyltransferase Rattus norvegicus 91-95 28559799-0 2017 The Effect of Serotonin-Targeting Antidepressants on Neurogenesis and Neuronal Maturation of the Hippocampus Mediated via 5-HT1A and 5-HT4 Receptors. Serotonin 14-23 5-hydroxytryptamine receptor 1A Homo sapiens 122-148 24854234-9 2014 When these channels are co-expressed with hSERT in HEK293T cells, only cells expressing the lower-threshold L-type CaV1.3 channel show Ca(2+) transients evoked by 5HT or S(+)MDMA. Serotonin 163-166 calcium voltage-gated channel subunit alpha1 D Homo sapiens 115-121 24854234-10 2014 In addition, the electrical coupling between hSERT and CaV1.3 takes place at physiological 5HT concentrations. Serotonin 91-94 calcium voltage-gated channel subunit alpha1 D Homo sapiens 55-61 24982234-1 2014 BACKGROUND/AIM: Indoleamine 2, 3-dioxygenase (IDO) induction has been suggested as a mechanism by which immune activation affects tryptophan metabolism and serotonin synthesis in major depressive disorder (MDD). Serotonin 156-165 indoleamine 2,3-dioxygenase 1 Homo sapiens 16-44 24982234-1 2014 BACKGROUND/AIM: Indoleamine 2, 3-dioxygenase (IDO) induction has been suggested as a mechanism by which immune activation affects tryptophan metabolism and serotonin synthesis in major depressive disorder (MDD). Serotonin 156-165 indoleamine 2,3-dioxygenase 1 Homo sapiens 46-49 7219870-1 1981 The activities of monoamine oxidase (MAO)-A and -B in subcellular fractions of bovine retina were determined using serotonin and beta-phenylethylamine, respectively, as substrates. Serotonin 115-124 monoamine oxidase A Bos taurus 18-50 28185898-13 2017 These results suggest that Sirt2 inhibition induce antidepressant-like action and this effect could be mediated by modulation of glutamate and serotonin system in the PFC. Serotonin 143-152 sirtuin 2 Mus musculus 27-32 6263577-0 1981 Reciprocal relationship between the concentrations of serotonin and the activity of serotonin-N-acetyltransferase in rat pineal glands in culture. Serotonin 54-63 aralkylamine N-acetyltransferase Rattus norvegicus 84-113 27979380-7 2017 Interestingly, NPY decreased brain serotonin and norepinephrine concentrations in fed chicks, but increased concentrations of brain dopamine and its metabolites in fasted and fed chicks, respectively. Serotonin 35-44 neuropeptide Y Homo sapiens 15-18 23719026-6 2014 The melatonin MT1/MT2 agonist and 5-HT(2C) antagonist, agomelatine, which is effective in the short- and long-term treatment of depression, exemplifies the former approach, while evidence-based polypharmacy is illustrated by the adjunctive use of second-generation antipsychotics with serotonin reuptake inhibitors for treatment of resistant depression. Serotonin 285-294 metallothionein 1I, pseudogene Homo sapiens 14-17 23719026-6 2014 The melatonin MT1/MT2 agonist and 5-HT(2C) antagonist, agomelatine, which is effective in the short- and long-term treatment of depression, exemplifies the former approach, while evidence-based polypharmacy is illustrated by the adjunctive use of second-generation antipsychotics with serotonin reuptake inhibitors for treatment of resistant depression. Serotonin 285-294 metallothionein 2A Homo sapiens 18-21 24614691-5 2014 Functionally, we have found that expression of MAP1B-LC1 regulates serotonin signaling in a receptor subtype-specific manner, specifically controlling the activities of 5-HT6R, but not those of 5-HT4R and 5-HT7R. Serotonin 67-76 microtubule associated protein 1B Homo sapiens 47-52 24627634-14 2014 Serotonin toxicity via a low dose of paroxetine that is coadministered with perospirone, which acts agonistically on the 5-HT1A receptor and antagonistically on the 5-HT2A receptor, clearly indicated 5-HT1A receptor involvement in mild serotonin toxicity. Serotonin 236-245 5-hydroxytryptamine receptor 1A Homo sapiens 200-215 24627634-15 2014 Careful measures should be adopted to avoid serotonin toxicity following the combined use of SSRIs and 5-HT1A agonists. Serotonin 44-53 5-hydroxytryptamine receptor 1A Homo sapiens 103-109 28298427-4 2017 To demonstrate the biological relevance of the GPCR interactome, we validated novel interactions of the GPR37, serotonin 5-HT4d, and adenosine ADORA2A receptors. Serotonin 111-120 adenosine A2a receptor Homo sapiens 143-150 6787636-7 1981 The activation, probably centrally elicited, of brain NA and 5-hydroxytryptamine systems by the subchronic salbutamol regimen supports the concept of beta-adrenoceptor mediated regulation of brain monoamine systems, and could contribute to the clinically reported antidepressant activity of beta-2-adrenoceptor agonists. Serotonin 61-80 adrenoceptor beta 2 Rattus norvegicus 291-310 28337123-5 2017 Mecp2-/y mice are an established animal model for RTT displaying most of the cognitive and physical impairments of human patients and the selected areas receive significant modulation through serotonin. Serotonin 192-201 methyl CpG binding protein 2 Mus musculus 0-5 6159865-6 1980 Reduction of CSF concentrations of 5-HIAA, which probably reflects drug action on central serotonin neurons, was maximal at a plasma clomipramine concentration of about 300 nmole/L. Serotonin 90-99 colony stimulating factor 2 Homo sapiens 13-16 27859267-1 2017 KEY POINTS: In the adult turtle spinal cord, action potential generation in motoneurones is inhibited by spillover of serotonin to extrasynaptic serotonin 1A (5-HT1A ) receptors at the axon initial segment. Serotonin 118-127 5-hydroxytryptamine receptor 1A Homo sapiens 159-165 6158559-2 1980 CSF indoleacetic acid reflects CNS tyrptamine metabolism in the same way that CSF 5-hydroxyindoleacetic acid reflects CNS 5-hydroxytryptamine metabolism. Serotonin 122-141 colony stimulating factor 2 Homo sapiens 78-81 28292464-2 2017 Acidic pHo increases the uptake of adenosine and 5-hydroxytryptamine (5HT) via hENT4 in this cell type. Serotonin 49-68 solute carrier family 29 member 4 Homo sapiens 79-84 6155770-0 1980 Effects of the histamine H2-receptor agonists dimaprit and 4-methylhistamine on the central noradrenaline and serotonin system. Serotonin 110-119 histamine receptor H 2 Rattus norvegicus 15-36 28292464-2 2017 Acidic pHo increases the uptake of adenosine and 5-hydroxytryptamine (5HT) via hENT4 in this cell type. Serotonin 70-73 solute carrier family 29 member 4 Homo sapiens 79-84 20227955-2 1980 With 5-hydroxytryptamine (5-HT), beta-phenylethylamine (PEA) and benzylamine (Bz) as substrates and clorgyline and deprenyl, respectively, as selective MAO A and B inhibitors, their activity pattern has been defined and compared with that of human liver. Serotonin 26-30 monoamine oxidase A Homo sapiens 152-157 28052533-3 2017 Inhibitors that act on MAO A are used to treat depression, due to their ability to raise serotonin concentrations, whereas MAO B inhibitors decrease dopamine degradation and improve motor control in patients with Parkinson disease. Serotonin 89-98 monoamine oxidase A Homo sapiens 23-28 7364455-1 1980 Rabbit anti-human platelet antiserum (RPA) has been shown to mediate human platelet aggregation and 14C-serotonin release. Serotonin 104-113 replication protein A1 Homo sapiens 38-41 27866207-5 2017 The genomic DNA collected and stored in a -70 C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of monoamine oxidase A (MAO-A). Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 136-160 6113600-4 1980 In slices of the facial motor nucleus from rat brainstem, serotonin (5-HT) added to the incubation medium stimulates the phosphorylation of Protein I. Serotonin 58-67 annexin A2 Rattus norvegicus 140-149 27657308-0 2016 Serotonin, estrus, and social context influence c-Fos immunoreactivity in the inferior colliculus. Serotonin 0-9 FBJ osteosarcoma oncogene Mus musculus 48-53 27657308-10 2016 These findings show that the effects of serotonin on c-Fos activity in the IC of females is dependent on both external context and reproductive state, and suggest that these effects occur downstream of serotonin release. Serotonin 40-49 FBJ osteosarcoma oncogene Mus musculus 53-58 27657308-10 2016 These findings show that the effects of serotonin on c-Fos activity in the IC of females is dependent on both external context and reproductive state, and suggest that these effects occur downstream of serotonin release. Serotonin 202-211 FBJ osteosarcoma oncogene Mus musculus 53-58 27710862-6 2016 This supports the hypothesis that SPX may be involved in the hypothalamic serotonin-dependent actions of SSRI antidepressants and possibly also in the central mechanism of body mass increase. Serotonin 74-83 spexin hormone Rattus norvegicus 34-37 6248844-2 1980 In this study the effects of pharmacological manipulation of 5-hydroxytryptamine (5-HT) on the antinociceptive activity of morphine and two synthetic enkephalin analogus (D-ala2-leu-enkephalin and D-ala2-met-enkephalin) were investigated in mice and rats. Serotonin 82-86 proenkephalin Rattus norvegicus 150-160 420544-2 1979 The CSF metabolites of serotonin and dopamine, 5-hydroxyindoleacetic acid (5HIAA), and homovanillic acid (HVA) were studied in hospitalized alcoholics. Serotonin 23-32 colony stimulating factor 2 Homo sapiens 4-7 1147723-1 1975 Metoclopramide [(Mcp)-N-diethylaminoethyl-2-methoxy-4-amino-5-chloro-benzamide] was shown by the authors (This Journal 1973, 204, 239) to stimulate the isolated guinea-pig ileum, mainly by an indirecr cholinergic mechanism, to increase responses to acetylcholine (Ac) and transmural stimulation, and to inhibit responses to serotonin (5 HT) and histamine (H). Serotonin 324-333 membrane cofactor protein Cavia porcellus 17-20 29634109-2 2016 The highest affinity for serotonin 5-HT1A/2A/7 receptors was found for compounds containing a tetralin or indane moiety in the imide part. Serotonin 25-34 5-hydroxytryptamine receptor 1A Homo sapiens 35-41 4930475-0 1971 Fusaric (5-butylpicolinic) acid, an inhibitor of dopamine beta-hydroxylase, affects serotonin and noradrenaline. Serotonin 84-93 dopamine beta-hydroxylase Homo sapiens 49-74 27339900-1 2016 Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep. Serotonin 47-56 aralkylamine N-acetyltransferase Rattus norvegicus 0-29 27339900-1 2016 Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep. Serotonin 47-56 aralkylamine N-acetyltransferase Rattus norvegicus 31-36 5312813-0 1970 Stimulation by serotonin of erythropoietin-dependent erythropoiesis in mice. Serotonin 15-24 erythropoietin Mus musculus 28-42 27432060-3 2016 Microglia and toll-like receptor 4 play a crucial role in triggering wide and varied stress-induced responses mediated through activation of the inflammasome; this leads to the secretion of inflammatory cytokines, increased serotonin metabolism, and reduction of neurotransmitter availability along with hypothalamic-pituitary-adrenal axis hyperactivity. Serotonin 224-233 toll like receptor 4 Homo sapiens 14-34 14004499-0 1961 Oxidation of reduced phosphopyridine nucleotides by p-phenylenediamines, catecholamines and serotonin in the presence of ceruloplasmin. Serotonin 92-101 ceruloplasmin Homo sapiens 121-134 27436416-6 2016 Genetic deletion of IDO1 in mice abrogated both the increase in depression-like behavior and the elevation in TRP metabolites" levels, and the turnover of serotonin in the frontal cortex after IFN-gamma gene transfer. Serotonin 155-164 indoleamine 2,3-dioxygenase 1 Mus musculus 20-24 27137992-6 2016 In contrast, damage to the serotonergic innervation of the ARC, which caused a decrease in serotonin level in the hypothalamic area containing the ARC, reduced the concentration of growth hormone and the expression and activity of CYP2C11. Serotonin 91-100 cytochrome P450, subfamily 2, polypeptide 11 Rattus norvegicus 231-238 13785077-1 1961 HC1 on DOPA, dopamine, norepinephrine, epinephrine and serotonin levels in mouse brain. Serotonin 55-64 heterochromatin, Chr 1 Mus musculus 0-3 13847033-0 1960 Serotonin degradation by ceruloplasmin and its inhibition by isoniazid and iproniazid. Serotonin 0-9 ceruloplasmin Homo sapiens 25-38 27497328-2 2016 The first and rate-limiting step in the synthesis of serotonin is catalyzed by tryptophan hydroxylase (TPH) which is encoded by TPH1 and THP2 genes. Serotonin 53-62 tryptophan hydroxylase 1 Homo sapiens 128-132 34000471-3 2021 Fluoxetine and 5-HT suppressed IL-17, IFN-gamma and GM-CSF production by stimulated SD4+ T-cells in both groups. Serotonin 15-19 colony stimulating factor 2 Homo sapiens 52-58 26585288-0 2016 Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling. Serotonin 75-84 brain derived neurotrophic factor Mus musculus 19-23 26585288-7 2016 Bdnf-e1 and -e2 mutant males displayed heightened aggression accompanied by convergent expression changes in specific genes associated with serotonin signaling. Serotonin 140-149 brain derived neurotrophic factor Mus musculus 0-4 23644750-2 2014 Serotonin (5HT) regulates the secretion of pituitary growth hormone (GH), which in turn stimulates the liver to produce insulin-like growth factor-I (IGF-I) that is necessary for development and growth. Serotonin 0-9 insulin-like growth factor 1 Rattus norvegicus 120-148 23644750-2 2014 Serotonin (5HT) regulates the secretion of pituitary growth hormone (GH), which in turn stimulates the liver to produce insulin-like growth factor-I (IGF-I) that is necessary for development and growth. Serotonin 0-9 insulin-like growth factor 1 Rattus norvegicus 150-155 23644750-2 2014 Serotonin (5HT) regulates the secretion of pituitary growth hormone (GH), which in turn stimulates the liver to produce insulin-like growth factor-I (IGF-I) that is necessary for development and growth. Serotonin 11-14 insulin-like growth factor 1 Rattus norvegicus 120-148 33657450-12 2021 Here, we showed a significant SSRI- and relearning-driven interaction effect of hippocampal and thalamic Glx/tCr levels, suggesting differential behavior based on different serotonin transporter and receptor densities. Serotonin 173-182 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 109-112 23644750-2 2014 Serotonin (5HT) regulates the secretion of pituitary growth hormone (GH), which in turn stimulates the liver to produce insulin-like growth factor-I (IGF-I) that is necessary for development and growth. Serotonin 11-14 insulin-like growth factor 1 Rattus norvegicus 150-155 26952453-3 2016 The simultaneous determination of dopamine in the presence of serotonin (5-HT) was found to exhibit very good response at poly-AzrS/MWCNTs/GCE. Serotonin 62-71 aminomethyltransferase Homo sapiens 139-142 33523585-4 2021 Aside from the well-characterized role in immune signalling, JAK2/STAT3, TLR2, and TLR4 are signal transducers linked to both immuno-modulatory actions of acetylcholine and serotonin. Serotonin 173-182 toll like receptor 4 Homo sapiens 83-87 26100147-0 2016 Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. Serotonin 96-105 brain derived neurotrophic factor Mus musculus 45-49 26100147-2 2016 Using a highly sensitive enzyme-linked immunosorbent assay, we studied BDNF concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (Tph)2-deficient (Tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (SERT)-deficient (SERT(-/-)) mice lacking serotonin re-uptake. Serotonin 148-157 brain derived neurotrophic factor Mus musculus 71-75 26100147-5 2016 Our results emphasize the interaction between serotonin signaling and BDNF. Serotonin 46-55 brain derived neurotrophic factor Mus musculus 70-74 26100147-6 2016 Complete lack of brain serotonin induces BDNF expression. Serotonin 23-32 brain derived neurotrophic factor Mus musculus 41-45 24351931-2 2014 This increase is driven by precisely regulated increases in acetylation of serotonin in the pineal gland by arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the synthesis of melatonin. Serotonin 75-84 arylalkylamine N-acetyltransferase 2 Callorhinchus milii 144-149 25087955-0 2014 Serotonin suppresses beta-casein expression via inhibition of the signal transducer and activator of transcription 5 (STAT5) protein phosphorylation in human mammary epithelial cells MCF-12A. Serotonin 0-9 casein beta Homo sapiens 21-32 25087955-0 2014 Serotonin suppresses beta-casein expression via inhibition of the signal transducer and activator of transcription 5 (STAT5) protein phosphorylation in human mammary epithelial cells MCF-12A. Serotonin 0-9 signal transducer and activator of transcription 5A Homo sapiens 118-123 33197939-1 2021 INTRODUCTION: Brain-derived neurotrophic factor (BDNF) has been implicated in the pro-neurogenic effect of selective serotonin reuptake inhibitors. Serotonin 117-126 brain derived neurotrophic factor Mus musculus 14-47 24385311-1 2014 UNLABELLED: The PET radioligand (11)C-CUMI-101 was previously suggested as a putative agonist radioligand for the serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor in recombinant cells expressing human 5-HT1A receptor. Serotonin 114-123 5-hydroxytryptamine receptor 1A Homo sapiens 208-223 24385311-1 2014 UNLABELLED: The PET radioligand (11)C-CUMI-101 was previously suggested as a putative agonist radioligand for the serotonin 1A (5-hydroxytryptamine 1A [5-HT1A]) receptor in recombinant cells expressing human 5-HT1A receptor. Serotonin 127-147 5-hydroxytryptamine receptor 1A Homo sapiens 208-223 26248159-4 2016 Treatment of PASMCs with the PAH mediators platelet-derived growth factor (PDGF), serotonin, H2O2, endothelin-1, and IL-6 caused significant increases in calpain activity, cell proliferation, and collagen-I protein level without changes in protein levels of calpain-1 and -2. Serotonin 82-91 calpain 1 Homo sapiens 258-274 33197939-1 2021 INTRODUCTION: Brain-derived neurotrophic factor (BDNF) has been implicated in the pro-neurogenic effect of selective serotonin reuptake inhibitors. Serotonin 117-126 brain derived neurotrophic factor Mus musculus 49-53 33905796-3 2021 The 5-HT1A receptor is the most widespread serotonin receptor, and participates in many brain-related disorders, including anxiety, depression, and cognitive impairments. Serotonin 43-52 5-hydroxytryptamine receptor 1A Homo sapiens 4-19 26836802-5 2016 By activating 5-HT1A receptors, serotonin inhibits TWIK-related acid-sensitive potassium channels and small conductance calcium-activated potassium channels. Serotonin 32-41 5-hydroxytryptamine receptor 1A Homo sapiens 14-20 26836802-8 2016 The reuptake systems saturate and serotonin spills over to reach extrasynaptic 5-HT1A receptors located on the axon initial segment of motoneurons. Serotonin 34-43 5-hydroxytryptamine receptor 1A Homo sapiens 79-85 24903772-0 2014 Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 35-39 24903772-0 2014 Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression. Serotonin 0-9 5-hydroxytryptamine receptor 5A Homo sapiens 44-49 33454530-10 2021 Meanwhile, KGM + X11 effectively promoted the metabolism of short-chain fatty acids in mice better than other combinations, and the 5-hydroxytryptamine (5-HT) content in the KGM + X11 group was the highest among all the groups. Serotonin 132-151 amyloid beta (A4) precursor protein binding, family A, member 1 Mus musculus 180-183 25322896-3 2014 In this study, two genes, 5HTR2a and MAO-A playing important roles in serotonin function, were analyzed in peripheral blood mononuclear cells (PBMCs) of individuals who had been exposed to air pollution and allergic asthmatic patients as well. Serotonin 70-79 monoamine oxidase A Homo sapiens 37-42 26446044-5 2016 These astrocytes produced high levels of soluble beta-amyloid (Abeta) which could be significantly inhibited by fluoxetine (FLX) via activating serotonin 5-HT2 receptors. Serotonin 144-153 amyloid beta (A4) precursor protein Mus musculus 49-69 33454530-10 2021 Meanwhile, KGM + X11 effectively promoted the metabolism of short-chain fatty acids in mice better than other combinations, and the 5-hydroxytryptamine (5-HT) content in the KGM + X11 group was the highest among all the groups. Serotonin 153-157 amyloid beta (A4) precursor protein binding, family A, member 1 Mus musculus 180-183 26573170-2 2016 This study explores the potential of the monoamine oxidase A (MAO-A) enzyme-based assay with polymeric dendrimers as cofactors and serotonin as substrate, which generates H2O2, quantified by the conversion of the Carboxy-H2DCFDA dye to its fluorescent form. Serotonin 131-140 monoamine oxidase A Homo sapiens 62-67 33454530-13 2021 CONCLUSIONS: The combination laxative konjac glucomannan-probiotic (KGM + X11) promoted defecation in constipated mice, possibly by increasing short-chain fatty acid metabolism and 5-HT hormone release. Serotonin 181-185 amyloid beta (A4) precursor protein binding, family A, member 1 Mus musculus 74-77 33611213-9 2021 Furthermore, the binding affinities and pKi values of WA, fluoxetine and serotonin as natural ligand to Ser-1, Ser-4, Ser-7, Mod-5 and their human orthologues proteins were calculated by molecular docking. Serotonin 73-82 tRNA isopentenyltransferase 1 Homo sapiens 125-130 25547097-3 2016 By decreasing the availability of tryptophan for serotonin synthesis, such IDO and TDO-driven TRYCATs, also decrease the availability of serotonin for N-acetylserotonin (NAS) and melatonin synthesis. Serotonin 49-58 indoleamine 2,3-dioxygenase 1 Homo sapiens 75-78 25547097-3 2016 By decreasing the availability of tryptophan for serotonin synthesis, such IDO and TDO-driven TRYCATs, also decrease the availability of serotonin for N-acetylserotonin (NAS) and melatonin synthesis. Serotonin 137-146 indoleamine 2,3-dioxygenase 1 Homo sapiens 75-78 24376420-8 2013 The influence of cacao extracts on IDO activity could be of particular relevance for some of the beneficial health effects ascribed to cacao: tryptophan breakdown by IDO is strongly involved in immunoregulation, and the diminished availability of tryptophan limits the biosynthesis of neurotransmitter serotonin. Serotonin 302-311 indoleamine 2,3-dioxygenase 1 Homo sapiens 35-38 24376420-8 2013 The influence of cacao extracts on IDO activity could be of particular relevance for some of the beneficial health effects ascribed to cacao: tryptophan breakdown by IDO is strongly involved in immunoregulation, and the diminished availability of tryptophan limits the biosynthesis of neurotransmitter serotonin. Serotonin 302-311 indoleamine 2,3-dioxygenase 1 Homo sapiens 166-169 24239122-7 2013 Importantly, an additive ARM deficit occurred when Tbetah knockdown in the APL neurons was in the radish mutant flies or in the wild-type flies with inhibited serotonin synthesis. Serotonin 159-168 Tyramine beta hydroxylase Drosophila melanogaster 51-57 26763435-0 2016 Involvement of TRPV4 in Serotonin-Evoked Scratching. Serotonin 24-33 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 15-20 23619963-9 2013 Serotonin significantly increased the cytoplasmatic beta-catenin protein levels by the inhibition of the enzyme glycogen synthase kinase-3beta, that by phosphorylating beta-catenin promotes its degradation. Serotonin 0-9 catenin beta 1 Rattus norvegicus 52-64 23619963-9 2013 Serotonin significantly increased the cytoplasmatic beta-catenin protein levels by the inhibition of the enzyme glycogen synthase kinase-3beta, that by phosphorylating beta-catenin promotes its degradation. Serotonin 0-9 catenin beta 1 Rattus norvegicus 168-180 23619963-11 2013 We suggest that serotonin might stimulate canonical Wnt/beta-catenin-dependent bone formation to occur. Serotonin 16-25 catenin beta 1 Rattus norvegicus 56-68 33609226-7 2021 An immunohistochemical analysis revealed TAS2R14 immunoreactivity in enteroendocrine cells positive for cholecystokinin, serotonin, and the G protein GNAT3. Serotonin 121-130 taste 2 receptor member 14 Homo sapiens 41-48 24076393-2 2013 AANAT, which is expressed in the pineal gland, retina, and various other tissues, catalyzes the conversion of serotonin to N-acetylserotonin and is the rate-limiting enzyme in the biosynthetic pathway of melatonin. Serotonin 110-119 aralkylamine N-acetyltransferase Rattus norvegicus 0-5 33210730-3 2021 Here we focus on the possible ionic mechanisms that underlie the observed programming of the electrophysiological properties of serotonin neurons, focusing on the twin-pore K+ channels TREK-1 and TASK-1 that set resting membrane potential and regulate excitability. Serotonin 128-137 potassium channel, subfamily K, member 2 Mus musculus 185-191 23142150-3 2013 In particular, protein levels of Tumor Necrosis Factor (TNF) and the SNPs rs1126757 in interleukin-11 (IL11), and rs7801617 in interleukin-6 (IL6), have previously been implicated in the clinical response to the selective serotonin reuptake inhibitor (SSRI) antidepressant escitalopram. Serotonin 222-231 interleukin 11 Homo sapiens 87-101 26710093-1 2016 OBJECTIVE: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. Serotonin 136-145 tryptophan hydroxylase 1 Homo sapiens 15-39 26710093-1 2016 OBJECTIVE: The tryptophan hydroxylase 1 gene (TPH1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. Serotonin 136-145 tryptophan hydroxylase 1 Homo sapiens 46-50 26711020-0 2016 Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study. Serotonin 73-82 aldehyde dehydrogenase 2, mitochondrial Mus musculus 86-91 23664790-0 2013 Neurokinin-1 receptor-expressing neurons that contain serotonin and gamma-aminobutyric acid in the rat rostroventromedial medulla are involved in pain processing. Serotonin 54-63 tachykinin receptor 1 Rattus norvegicus 0-21 33210730-6 2021 We then quantified Kcnk2 mRNA levels specifically in dorsal raphe 5-HT neurons using triple-label RNAscope. Serotonin 66-70 potassium channel, subfamily K, member 2 Mus musculus 19-24 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 72-81 potassium channel, subfamily K, member 2 Mus musculus 63-68 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 72-81 potassium channel, subfamily K, member 2 Mus musculus 177-183 27336729-1 2016 BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT), originating from the enterochromaffin cells has been reported to mediate the contractile effect of the sensory stimulant and TRPA1 activator allyl isothiocyanate (AITC) in the guinea-pig small intestine [Nozawa et al: Proc Natl Acad Sci U S A 2009;106:3408-3413]. Serotonin 12-21 transient receptor potential cation channel subfamily A member 1 Cavia porcellus 176-181 27336729-1 2016 BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT), originating from the enterochromaffin cells has been reported to mediate the contractile effect of the sensory stimulant and TRPA1 activator allyl isothiocyanate (AITC) in the guinea-pig small intestine [Nozawa et al: Proc Natl Acad Sci U S A 2009;106:3408-3413]. Serotonin 23-42 transient receptor potential cation channel subfamily A member 1 Cavia porcellus 176-181 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 358-362 potassium channel, subfamily K, member 2 Mus musculus 63-68 23858446-2 2013 The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses. Serotonin 83-92 monoamine oxidase A Homo sapiens 27-38 33210730-7 2021 We found that Long photoperiod significantly reduced levels of Kcnk2 in serotonin neurons co-expressing Tph2, and Pet-1, Photoperiodic effects on the function and expression of TREK-1 were blocked in melatonin 1 receptor knockout (MT-1KO) mice, consistent with previous findings that MT-1 signaling is necessary for photoperiodic programming of dorsal raphe 5-HT neurons. Serotonin 358-362 potassium channel, subfamily K, member 2 Mus musculus 177-183 23858446-2 2013 The combined deficiency of MAO A and B results in significantly elevated levels of serotonin (5-hydroxytryptamine), norepinephrine, dopamine, and beta-phenylethylamine; in humans and mice, these neurochemical changes are accompanied by neurodevelopmental perturbations as well as autistic-like responses. Serotonin 94-113 monoamine oxidase A Homo sapiens 27-38 33210730-8 2021 Taken together these results indicate that photoperiodic regulation of TREK-1 expression and function plays a key role in photoperiodic programming the excitability of dorsal raphe 5-HT neurons. Serotonin 181-185 potassium channel, subfamily K, member 2 Mus musculus 71-77 26696889-2 2015 The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5-hydroxytryptamine; 5-HT) receptor binding sites, particularly of the 1A receptor (5-HT1A) subtype. Serotonin 106-115 5-hydroxytryptamine receptor 1A Homo sapiens 201-207 33158691-4 2021 Vilazodone blocks the serotonin reuptake pump and desensitizes serotonin receptors (especially 5HT1A autoreceptors), therefore increasing serotonergic neurotransmission. Serotonin 63-72 5-hydroxytryptamine receptor 1A Homo sapiens 95-100 26696889-2 2015 The hippocampus, which has a central role in spatial cognition, is characterized by high concentration of serotonin (5-hydroxytryptamine; 5-HT) receptor binding sites, particularly of the 1A receptor (5-HT1A) subtype. Serotonin 117-136 5-hydroxytryptamine receptor 1A Homo sapiens 201-207 26373603-4 2015 MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Serotonin 40-49 Transporter Caenorhabditis elegans 0-5 23669068-0 2013 Acute and subchronic treatments with selective serotonin reuptake inhibitors increase Nociceptin/Orphanin FQ (NOP) receptor density in the rat dorsal raphe nucleus; interactions between nociceptin/NOP system and serotonin. Serotonin 47-56 prepronociceptin Rattus norvegicus 86-96 23669068-0 2013 Acute and subchronic treatments with selective serotonin reuptake inhibitors increase Nociceptin/Orphanin FQ (NOP) receptor density in the rat dorsal raphe nucleus; interactions between nociceptin/NOP system and serotonin. Serotonin 47-56 prepronociceptin Rattus norvegicus 97-123 23669068-0 2013 Acute and subchronic treatments with selective serotonin reuptake inhibitors increase Nociceptin/Orphanin FQ (NOP) receptor density in the rat dorsal raphe nucleus; interactions between nociceptin/NOP system and serotonin. Serotonin 47-56 prepronociceptin Rattus norvegicus 186-196 23578138-0 2013 Serotonin and the 5-HT7 receptor: the link between hepatocytes, IGF-1 and small intestinal neuroendocrine tumors. Serotonin 0-9 insulin-like growth factor 1 Rattus norvegicus 64-69 26373603-4 2015 MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Serotonin 40-49 ataxin 3 Mus musculus 174-182 26373603-4 2015 MOD-5, the C. elegans orthologue of the serotonin transporter and cellular target of citalopram, and the serotonin receptors SER-1 and SER-4 were strong genetic modifiers of ataxin 3 neurotoxicity and necessary for therapeutic efficacy. Serotonin 105-114 ataxin 3 Mus musculus 174-182 33517848-4 2021 Fluoxetine treatment increased lipid accumulation in association with increased mRNA expression of tryptophan hydroxylase 1 (Tph1, serotonin biosynthetic enzyme) and intracellular serotonin content. Serotonin 134-143 tryptophan hydroxylase 1 Homo sapiens 99-123 26021702-7 2015 Furthermore, we demonstrate that the reduction of glutamatergic transmission by serotonin is likely to be mediated via a decrease of calcium influx into presynaptic terminals of CA1 pyramidal cells. Serotonin 80-89 carbonic anhydrase 1 Rattus norvegicus 178-181 26250886-3 2015 Previously, we have shown that kisspeptin 1 (Kiss1) expressing in the vHb, regulates the serotonin (5-HT) system in the MR. Serotonin 89-98 KiSS-1 metastasis suppressor Danio rerio 31-43 26250886-3 2015 Previously, we have shown that kisspeptin 1 (Kiss1) expressing in the vHb, regulates the serotonin (5-HT) system in the MR. Serotonin 89-98 KiSS-1 metastasis suppressor Danio rerio 45-50 26260570-3 2015 Ghrelin and leptin are peptide hormones which are involved in the regulation of hunger/satiety and are related to serotonin. Serotonin 114-123 leptin Homo sapiens 12-18 26412054-2 2015 The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain. Serotonin 210-219 5-hydroxytryptamine receptor 1A Homo sapiens 43-49 26412054-2 2015 The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain. Serotonin 210-219 5-hydroxytryptamine receptor 1A Homo sapiens 72-78 26209276-1 2015 Tissue transglutaminase 2 (TG2) is an enzyme with multiple functions, including catalysis of serotonin conjugation to proteins (serotonylation). Serotonin 93-102 transglutaminase 2, C polypeptide Mus musculus 7-25 26209276-1 2015 Tissue transglutaminase 2 (TG2) is an enzyme with multiple functions, including catalysis of serotonin conjugation to proteins (serotonylation). Serotonin 93-102 transglutaminase 2, C polypeptide Mus musculus 27-30 26370232-9 2015 Furthermore, we found that PP2-expressing cells contain serotonin and aanat2, the key enzyme involved in melatonin synthesis from serotonin, whereas PP1-expressing cells do not contain either, suggesting that blue-sensitive PP2 is instead involved in light-regulation of melatonin secretion. Serotonin 56-65 parapinopsin b Danio rerio 27-30 26370232-9 2015 Furthermore, we found that PP2-expressing cells contain serotonin and aanat2, the key enzyme involved in melatonin synthesis from serotonin, whereas PP1-expressing cells do not contain either, suggesting that blue-sensitive PP2 is instead involved in light-regulation of melatonin secretion. Serotonin 56-65 parapinopsin b Danio rerio 224-227 26141847-8 2015 These data are consistent with the hypothesis that relaxin-3 systems in the NI and serotonin systems in the DR interact to form part of a network involved in the control of anxiety-related behavior. Serotonin 83-92 relaxin 3 Rattus norvegicus 51-60 26220374-2 2015 Snap25(S187A/S187A) mice exhibit several distinct phenotypes, including reductions in dopamine and serotonin release in the brain, anxiety-like behavior, and cognitive dysfunctions. Serotonin 99-108 synaptosomal-associated protein 25 Mus musculus 0-6 26675681-2 2015 In this study, we investigated the correlations between the blood levels of each glycero-LPL and serotonin, a biomarker of platelet activation, in human subjects to elucidate the involvement of platelet activation in glycero-LPLs in vivo. Serotonin 97-106 lipoprotein lipase Homo sapiens 89-92 25594545-11 2015 In particular, increased methylation and decreased gene expression were observed in the Aanat gene, which is involved in converting serotonin to the circadian hormone melatonin and is implicated in sleep disturbance and depression associated with traumatic brain injury. Serotonin 132-141 aralkylamine N-acetyltransferase Rattus norvegicus 88-93 25092247-7 2015 In vivo pharmacology and western blot experiments argue for increased serotonin tonus as a main mechanism for impaired GSK3beta signaling in OCT2(-/-) mice brain during acute response to stress. Serotonin 70-79 glycogen synthase kinase 3 beta Mus musculus 119-127 25933983-5 2015 The mechanisms involving NMDA and AMPA glutamate, 5-HT1A serotonin and the GPR39 zinc-sensing receptor and intracellular pathways will be discussed. Serotonin 57-66 5-hydroxytryptamine receptor 1A Homo sapiens 50-56 25537017-6 2015 Leptin reduced ATP and increased serotonin release in response to sweet stimulation. Serotonin 33-42 leptin Mus musculus 0-6 25966107-6 2015 Based on the gene expression profiles of the 8 types of liver cells, 5-hydroxytryptamine promoted hepatocyte proliferation through the RAS and STAT3 signaling pathways, proliferation and differentiation of sinusoidal endothelial cells through the STAT3 signaling pathway, and proliferation and apoptosis of pit cells through the AKT3 signaling pathway. Serotonin 69-88 signal transducer and activator of transcription 3 Rattus norvegicus 143-148 25966107-6 2015 Based on the gene expression profiles of the 8 types of liver cells, 5-hydroxytryptamine promoted hepatocyte proliferation through the RAS and STAT3 signaling pathways, proliferation and differentiation of sinusoidal endothelial cells through the STAT3 signaling pathway, and proliferation and apoptosis of pit cells through the AKT3 signaling pathway. Serotonin 69-88 signal transducer and activator of transcription 3 Rattus norvegicus 247-252 25554480-5 2015 Inflammatory cytokines increase the activity of indoleamine 2,3-dioxygenase (IDO) and kynurenine 3-monooxygenase (KMO), which competitively reduce serotonin synthesis. Serotonin 147-156 indoleamine 2,3-dioxygenase 1 Mus musculus 48-75 25554480-5 2015 Inflammatory cytokines increase the activity of indoleamine 2,3-dioxygenase (IDO) and kynurenine 3-monooxygenase (KMO), which competitively reduce serotonin synthesis. Serotonin 147-156 indoleamine 2,3-dioxygenase 1 Mus musculus 77-80 23675993-1 2013 The discovery and synthesis of potential and novel antipsychotic coumarin derivatives, associated with potent dopamine D2, D3, and serotonin 5-HT1A and 5-HT2A receptor properties, are the focus of the present article. Serotonin 131-140 5-hydroxytryptamine receptor 1A Homo sapiens 141-153 23675993-3 2013 This derivative possesses unique pharmacological features, including high affinity for dopamine D2 and D3 and serotonin 5-HT1A and 5-HT2A receptors. Serotonin 110-119 5-hydroxytryptamine receptor 1A Homo sapiens 120-132 23428704-3 2013 T50 is reduced by acute treatment with 5-hydroxytryptamine (5-HT1A, 5-HT2A) and dopamine (D1-like, D2-like) receptor agonists. Serotonin 39-58 5-hydroxytryptamine receptor 1A Homo sapiens 60-66 23315169-3 2013 We recently demonstrated that, like VEGF-A, histamine and serotonin up-regulate the orphan nuclear receptor and transcription factor TR3 (mouse homolog Nur77) and that TR3/Nur77 is essential for their vascular permeabilizing activities. Serotonin 58-67 nuclear receptor subfamily 4, group A, member 1 Mus musculus 133-136 23315169-3 2013 We recently demonstrated that, like VEGF-A, histamine and serotonin up-regulate the orphan nuclear receptor and transcription factor TR3 (mouse homolog Nur77) and that TR3/Nur77 is essential for their vascular permeabilizing activities. Serotonin 58-67 nuclear receptor subfamily 4, group A, member 1 Mus musculus 152-157 23315169-3 2013 We recently demonstrated that, like VEGF-A, histamine and serotonin up-regulate the orphan nuclear receptor and transcription factor TR3 (mouse homolog Nur77) and that TR3/Nur77 is essential for their vascular permeabilizing activities. Serotonin 58-67 nuclear receptor subfamily 4, group A, member 1 Mus musculus 172-177 23080076-5 2013 In this study, we evaluated the (1) expression of arylalkylamine N-acetyltransferase (AANAT; the rate-limiting enzyme for melatonin synthesis from serotonin) in cholangiocytes and (2) effect of local modulation of biliary AANAT expression on the autocrine proliferative/secretory responses of cholangiocytes. Serotonin 147-156 aralkylamine N-acetyltransferase Rattus norvegicus 50-84 23080076-5 2013 In this study, we evaluated the (1) expression of arylalkylamine N-acetyltransferase (AANAT; the rate-limiting enzyme for melatonin synthesis from serotonin) in cholangiocytes and (2) effect of local modulation of biliary AANAT expression on the autocrine proliferative/secretory responses of cholangiocytes. Serotonin 147-156 aralkylamine N-acetyltransferase Rattus norvegicus 86-91 23090625-1 2013 INTRODUCTION: Serotonin and norepinephrine reuptake inhibitors (SNRIs) are antidepressants which have high affinity to both serotonin transporter (SERT) and norepinephrine transporter (NET). Serotonin 14-23 sodium-dependent serotonin transporter Macaca fascicularis 124-145 23090625-1 2013 INTRODUCTION: Serotonin and norepinephrine reuptake inhibitors (SNRIs) are antidepressants which have high affinity to both serotonin transporter (SERT) and norepinephrine transporter (NET). Serotonin 14-23 sodium-dependent serotonin transporter Macaca fascicularis 147-151 22975078-0 2013 Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes. Serotonin 54-63 insulin receptor substrate 1 Homo sapiens 87-115 23248270-4 2013 We show that activation of 5-hydroxytryptamine (5-HT) type 2A receptors to serotonin hyperpolarizes the reversal potential of inhibitory postsynaptic potentials (IPSPs), E(IPSP), in spinal motoneurons, increases the cell membrane expression of KCC2 and both restores endogenous inhibition and reduces spasticity after SCI in rats. Serotonin 27-46 solute carrier family 12 member 5 Rattus norvegicus 244-248 23248270-4 2013 We show that activation of 5-hydroxytryptamine (5-HT) type 2A receptors to serotonin hyperpolarizes the reversal potential of inhibitory postsynaptic potentials (IPSPs), E(IPSP), in spinal motoneurons, increases the cell membrane expression of KCC2 and both restores endogenous inhibition and reduces spasticity after SCI in rats. Serotonin 75-84 solute carrier family 12 member 5 Rattus norvegicus 244-248 23087024-3 2013 OBJECTIVES: Here we use both imatinib and knockout animals to determine the relationship between platelet-derived growth factor receptor (PDGFR) and serotonin signaling and investigate the PAH pathologies each mediates. Serotonin 149-158 platelet derived growth factor receptor, beta polypeptide Mus musculus 97-136 23087024-3 2013 OBJECTIVES: Here we use both imatinib and knockout animals to determine the relationship between platelet-derived growth factor receptor (PDGFR) and serotonin signaling and investigate the PAH pathologies each mediates. Serotonin 149-158 platelet derived growth factor receptor, beta polypeptide Mus musculus 138-143 24158140-8 2013 These results suggest that EGR-1 plays a role in the interplay of acetylcholine and serotonin in the regulation of neurite extension during development. Serotonin 84-93 early growth response 1 Mus musculus 27-32 23010892-0 2013 Serotonin regulates 6-phosphofructo-1-kinase activity in a PLC-PKC-CaMK II- and Janus kinase-dependent signaling pathway. Serotonin 0-9 calcium/calmodulin-dependent protein kinase II gamma Mus musculus 67-74 23805714-1 2013 Peptides of the insulin superfamily (insulin, insulin-like growth factor, relaxin), epidermal.growth factor (ECF) and biogenic amines (isoproterenol, adrenalin, noradrenalin, serotonin) stimulate the adenylyl cyclase signaling system (ACSS). Serotonin 175-184 epidermal growth factor Homo sapiens 84-107 23469282-6 2013 Here, we examined the expression profile of the HDAC protein family from HDAC1 to HDAC11 in corticotropin-releasing hormone, oxytocin, vasopressin, agouti-related peptide (AgRP), pro-opiomelanocortin (POMC), orexin, histamine, dopamine, serotonin, and noradrenaline neurons. Serotonin 237-246 histone deacetylase 11 Homo sapiens 82-88 22951050-1 2013 Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine originally identified in the pineal gland, where it is synthesised enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole O-methyltransferase). Serotonin 145-154 aralkylamine N-acetyltransferase Rattus norvegicus 205-239 22951050-1 2013 Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine originally identified in the pineal gland, where it is synthesised enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole O-methyltransferase). Serotonin 145-154 aralkylamine N-acetyltransferase Rattus norvegicus 241-246 22951050-1 2013 Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine originally identified in the pineal gland, where it is synthesised enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole O-methyltransferase). Serotonin 156-175 aralkylamine N-acetyltransferase Rattus norvegicus 205-239 22951050-1 2013 Melatonin (N-acetyl-5-methoxytryptamine) is an indoleamine originally identified in the pineal gland, where it is synthesised enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole O-methyltransferase). Serotonin 156-175 aralkylamine N-acetyltransferase Rattus norvegicus 241-246 23759691-4 2013 The MST-KO mice showed significantly increased anxiety-like behaviors with an increase in serotonin level in the prefrontal cortex (PFC), but not with abnormal morphological changes in the brain. Serotonin 90-99 mercaptopyruvate sulfurtransferase Mus musculus 4-7 22917617-0 2012 Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala. Serotonin 73-82 brain derived neurotrophic factor Mus musculus 18-51 22917617-5 2012 Examination of BDNF(2L/2LCk-Cre) mutant mice with brain-selective depletion of BDNF revealed mild decreases in serotonin content in the BLA. Serotonin 111-120 brain derived neurotrophic factor Mus musculus 15-19 22917617-5 2012 Examination of BDNF(2L/2LCk-Cre) mutant mice with brain-selective depletion of BDNF revealed mild decreases in serotonin content in the BLA. Serotonin 111-120 brain derived neurotrophic factor Mus musculus 79-83 22917617-8 2012 Collectively, the results indicate a required role of BDNF in serotonin transmission in the BLA. Serotonin 62-71 brain derived neurotrophic factor Mus musculus 54-58 22819262-4 2012 Here we discuss the recent finding of prodromal behavioral disturbances in a PINK1 deficient mouse that manifest prior to dopaminergic cell death and correlate to 5-HT fiber losses and mitochondrial morphological changes. Serotonin 163-167 PTEN induced putative kinase 1 Mus musculus 77-82 22683950-4 2012 Through G-protein-coupled receptors, serotonin at physiologically relevant concentrations activated Src/PI3K/AKT/mTOR/p70S6K phosphorylation signaling, and this activation was similar to that seen with VEGF. Serotonin 37-46 ribosomal protein S6 kinase B1 Homo sapiens 118-124 22538237-5 2012 CPI-17 transcription was suppressed in response to the proliferative stimulus with platelet-derived growth factor (PDGF) through the ERK1/2 pathway, whereas it was elevated in response to inflammatory, stress-induced and excitatory stimuli with transforming growth factor-beta, IL-1beta, TNFalpha, sorbitol, and serotonin. Serotonin 312-321 protein phosphatase 1 regulatory inhibitor subunit 14A Homo sapiens 0-6 22307675-5 2012 Additionally, 5-hydroxytryptamine-induced aortic contraction, a TG-activity-dependent process, was decreased to a greater extent by general TG inhibitors vs. Z-DON (maximum contraction: cystamine = abolished, monodansylcadaverine = 28.6 +- 14.9%, and Z-DON = 60.2 +- 15.2% vehicle), providing evidence for the importance of TG2-independent activity in the vasculature. Serotonin 14-33 transglutaminase 2, C polypeptide Mus musculus 324-327 25651169-3 2015 (2014) find that peripheral serotonin controls thermogenesis in adipose tissue by modulating beta-adrenergic stimulation of UCP-1, thereby affecting glucose homeostasis and weight gain. Serotonin 28-37 uncoupling protein 1 Homo sapiens 124-129 25557666-7 2015 Serotonin release elicited by direct optogenetic stimulation of serotonergic neurons activates HSF1 and upregulates molecular chaperones through the metabotropic serotonin receptor SER-1. Serotonin 0-9 Heat shock transcription factor hsf-1 Caenorhabditis elegans 95-99 25557666-10 2015 The ability of neurosensory release of serotonin to control cellular stress responses and activate HSF1 has powerful implications for the treatment of protein conformation diseases. Serotonin 39-48 Heat shock transcription factor hsf-1 Caenorhabditis elegans 99-103 25217810-8 2015 Serotonin interacts within the hypothalamus with endogenous orexigenic (Neuropeptide Y/Agouti related protein) and anorectic (alpha-melanocyte stimulating hormone) peptides. Serotonin 0-9 neuropeptide Y Homo sapiens 72-86 25451113-3 2015 Moreover, biochemical studies have revealed the up-regulation of other monoamine transporters (dopamine and serotonin) in the brains of NET-KO mice, similar to the phenomenon observed after the chronic pharmacological blockade of norepinephrine transporter by desipramine in wild-type (WT) animals. Serotonin 108-117 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 230-256 26630957-6 2015 Clinical evidence suggests serotonin (5-HT) 1A receptor agonist improves cognitive disturbances of schizophrenia, consistent with results from preclinical studies, through mechanism that corrects E-I imbalance via the suppression of GABA neural function. Serotonin 27-36 5-hydroxytryptamine receptor 1A Homo sapiens 38-55 25342126-7 2015 Furthermore, Htr4-null mice were more sensitive to serotonin-induced AHR. Serotonin 51-60 5 hydroxytryptamine (serotonin) receptor 4 Mus musculus 13-17 25370860-7 2015 As a study case, we show here the methodology in comparison to analysis with full arterial-line blood sampling in a cohort of 23 available scans with [(11)C]CUMI-101, a partial agonist of the serotonin 5-HT1A receptors. Serotonin 192-201 5-hydroxytryptamine receptor 1A Homo sapiens 202-208 25353084-7 2015 PAR-4 deficiency reduced plasma serotonin levels, increased serum bile acid concentration, and exacerbated ANIT-induced hepatocellular injury and peribiliary fibrosis. Serotonin 32-41 coagulation factor II (thrombin) receptor-like 3 Mus musculus 0-5 24158751-10 2014 As the G/G genotype of HTR1A (rs6295) involves in reducing serotonin neurotransmission, our results provide insight into the serotonin mechanism of cognitive function among women with PMDD. Serotonin 59-68 5-hydroxytryptamine receptor 1A Homo sapiens 23-28 24158751-10 2014 As the G/G genotype of HTR1A (rs6295) involves in reducing serotonin neurotransmission, our results provide insight into the serotonin mechanism of cognitive function among women with PMDD. Serotonin 125-134 5-hydroxytryptamine receptor 1A Homo sapiens 23-28 25247748-2 2014 Inspired by the finding that the receptor 5-HT1A modulates the level of serotonin in the brain, this study investigated to what extent a polymorphism (C-1019G, rs6295) of 5-HT1A gene modulates individuals" alexithymic characteristics and attachment orientation in 504 Chinese Han people. Serotonin 72-81 5-hydroxytryptamine receptor 1A Homo sapiens 42-48 25247748-2 2014 Inspired by the finding that the receptor 5-HT1A modulates the level of serotonin in the brain, this study investigated to what extent a polymorphism (C-1019G, rs6295) of 5-HT1A gene modulates individuals" alexithymic characteristics and attachment orientation in 504 Chinese Han people. Serotonin 72-81 5-hydroxytryptamine receptor 1A Homo sapiens 171-177 24862904-9 2014 Leptin is likely involved in behavioral regulation as leptin receptors are widely distributed in the brain, and leptin influences cortisol release, the mesoaccumbens dopamine pathway, serotonin synthesis, and hippocampal synaptic plasticity. Serotonin 184-193 leptin Homo sapiens 0-6 24862904-9 2014 Leptin is likely involved in behavioral regulation as leptin receptors are widely distributed in the brain, and leptin influences cortisol release, the mesoaccumbens dopamine pathway, serotonin synthesis, and hippocampal synaptic plasticity. Serotonin 184-193 leptin Homo sapiens 112-118 25346662-5 2014 Based on light and electron microscopy combined with anterograde and retrograde tracing, we found evidence that NTR2-immunoreactive (IR) neurons in the RVM receive NT-IR projections originating from the PAG; express NT, serotonin (5-HT), or both; and send projections that terminate in laminae I and II of the SDH. Serotonin 220-229 neurotensin receptor 2 Rattus norvegicus 112-116 25113046-1 2014 This paper reports the synthesis of new norbornene and exo-N-hydroxy-7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboximide derivatives and their binding to the 5-HT1A , 5-HT2A , and 5-HT2C receptors, in order to identify selective ligands for these 5-hydroxytryptamine (5-HT, serotonine) receptor subtypes. Serotonin 244-262 5-hydroxytryptamine receptor 1A Homo sapiens 154-160 24935787-0 2014 Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders. Serotonin 18-27 5-hydroxytryptamine receptor 1A Homo sapiens 28-34 24531562-5 2014 Serotonin promotes interactions with the scaffolding and regulatory protein, betaarrestin2, which results in the recruitment and activation of Akt. Serotonin 0-9 arrestin, beta 2 Mus musculus 77-90 24844635-3 2014 The coexpression of both inhibitory serotonin 5-HT1A receptors on the axon initial segments, and excitatory 5-HT2A receptors throughout the somatodendritic compartments, by layer 5 pyramidal neurons allows serotonin to provide potent top-down regulation of input-output relationships within cortical microcircuits. Serotonin 36-45 5-hydroxytryptamine receptor 1A Homo sapiens 46-52 24802806-7 2014 Based on preclinical studies, certain serotonin (5-HT) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-HT receptors acting at 5-HT1A, 5-HT4 and 5-HT6 receptors. Serotonin 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 189-195 24802806-7 2014 Based on preclinical studies, certain serotonin (5-HT) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-HT receptors acting at 5-HT1A, 5-HT4 and 5-HT6 receptors. Serotonin 49-53 5-hydroxytryptamine receptor 1A Homo sapiens 189-195 24802806-7 2014 Based on preclinical studies, certain serotonin (5-HT) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-HT receptors acting at 5-HT1A, 5-HT4 and 5-HT6 receptors. Serotonin 164-168 5-hydroxytryptamine receptor 1A Homo sapiens 189-195 24595007-3 2014 Brown Norway rat BMSCs stimulated with serotonin had increased expression of the smooth muscle markers smooth muscle myosin heavy chain (MHC) and alpha actin (alpha-SMA) by qPCR and Western blot, indicating smooth muscle differentiation. Serotonin 39-48 myosin heavy chain 11 Rattus norvegicus 103-135 24595007-5 2014 Serotonin upregulated serum response factor (SRF) and myocardin, transcription factors known to induce contractile protein expression in smooth muscle cells, while it down-regulated Elk1 and Kruppel-like factor 4 (KLF4), known to induce proliferation. Serotonin 0-9 serum response factor Rattus norvegicus 22-43 24595007-5 2014 Serotonin upregulated serum response factor (SRF) and myocardin, transcription factors known to induce contractile protein expression in smooth muscle cells, while it down-regulated Elk1 and Kruppel-like factor 4 (KLF4), known to induce proliferation. Serotonin 0-9 serum response factor Rattus norvegicus 45-48 24595007-6 2014 Serotonin increased SRF binding to promoter regions of the MHC and alpha-SMA genes, assessed by chromatin immunoprecipitation assay. Serotonin 0-9 serum response factor Rattus norvegicus 20-23 24595007-7 2014 Induction of smooth muscle differentiation by serotonin was blocked by the knock-down of SRF and myocardin. Serotonin 46-55 serum response factor Rattus norvegicus 89-92 24595007-10 2014 These findings demonstrate that serotonin promotes a smooth muscle-like phenotype in BMSCs by altering the balance of SRF, myocardin, Elk1 and KLF4 and miR-25-5p is involved in modulating this balance. Serotonin 32-41 serum response factor Rattus norvegicus 118-121 24291416-3 2014 In the current study X-chromosomal gene, MAOA responsible for degradation of serotonin is investigated for possible association with ASD using population-based approach. Serotonin 77-86 monoamine oxidase A Homo sapiens 41-45 24443391-3 2014 Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin. Serotonin 146-155 monoamine oxidase A Homo sapiens 244-263 24443391-3 2014 Several genetic variations have been suggested to associate with AD and DE, particularly in genes involved in the serotonergic system such as the serotonin transporter (SERT/SLC6A4), responsible for the removal from the synaptic cleft, and the monoamine-oxidase-A (MAOA), responsible for the presynaptic degradation of serotonin. Serotonin 146-155 monoamine oxidase A Homo sapiens 265-269 24627634-1 2014 We propose the possibility of 5-hydroxytryptamine (5-HT)1A receptor involvement in mild serotonin toxicity. Serotonin 88-97 5-hydroxytryptamine receptor 1A Homo sapiens 51-67 24627634-14 2014 Serotonin toxicity via a low dose of paroxetine that is coadministered with perospirone, which acts agonistically on the 5-HT1A receptor and antagonistically on the 5-HT2A receptor, clearly indicated 5-HT1A receptor involvement in mild serotonin toxicity. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 121-136 24627634-14 2014 Serotonin toxicity via a low dose of paroxetine that is coadministered with perospirone, which acts agonistically on the 5-HT1A receptor and antagonistically on the 5-HT2A receptor, clearly indicated 5-HT1A receptor involvement in mild serotonin toxicity. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 200-215 24231720-13 2014 PERSPECTIVE: This study is the first to show a vagus-mediated estrogenic antinociception, in which the nongenomic estrogen receptor beta-mediated, intestinal mucosal mast cell-derived 5-hydroxytryptamine/5-hydroxytryptamine 3 receptor pathway is involved. Serotonin 184-203 estrogen receptor 2 Rattus norvegicus 114-136 24075852-12 2014 Additionally, Parkin(-/-)DJ-1(-/-) mice exhibit improved rotarod performance and have increased serotonin in the striatum and hippocampus. Serotonin 96-105 Parkinson disease (autosomal recessive, early onset) 7 Mus musculus 25-29 24075852-14 2014 The results of our behavioral, neurochemical and immunohistochemical analyses reveal that PD-linked mutations in Parkin and DJ-1 cause dysregulation of neurotransmitter systems beyond the nigrostriatal dopaminergic circuit and that loss-of-function mutations in Parkin and DJ-1 lead to adaptive changes in dopamine and serotonin especially in the context of Gpx1 deficiency. Serotonin 319-328 Parkinson disease (autosomal recessive, early onset) 7 Mus musculus 124-128 24466315-3 2014 Upregulation of alpha-secretase activity through the 5-hydroxytryptamine 4 (5-HT4) receptor has been shown to reduce Abeta production, amyloid plaque load and to improve cognitive impairment in transgenic mouse models of AD. Serotonin 53-72 amyloid beta (A4) precursor protein Mus musculus 117-122 24903772-2 2014 The tryptophan hydroxylase-1 (TPH1) gene and serotonin 5A receptor (HTR5A) gene are known to be involved in serotonin biosynthesis and signal transduction, respectively. Serotonin 45-54 5-hydroxytryptamine receptor 5A Homo sapiens 68-73 24330646-1 2013 BACKGROUND: The significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2A (5HTR2A) in normal osteoblast proliferation have been previously described; however the role of serotonin in osteosarcoma remains unclear. Serotonin 252-261 5-hydroxytryptamine receptor 2A Canis lupus familiaris 157-163 24341715-5 2013 OPRM1 and the serotonin-related gene that regulates biosynthesis of serotonin (5HTR2A) showed a main effect of parity. Serotonin 68-77 opioid receptor, mu 1 Rattus norvegicus 0-5 24388892-8 2013 To our knowledge, depolarizing influence of 5HT on the single neurons in the IGL has been shown here for the first time. Serotonin 44-47 immunoglobulin lambda locus Homo sapiens 77-80 23602737-2 2013 A search of transcriptome data for the filarial nematode parasites Loa loa, Brugia malayi, and Wucheria bancrofti revealed predicted coding sequences for orthologs of acetylcholine, serotonin and dopamine-gated chloride channels, which correspond to the C. elegans clades acc-1, mod-1 and ggr-3, respectively. Serotonin 182-191 Acetylcholine-gated chloride channel subunit acc-1 Caenorhabditis elegans 272-294 23602737-6 2013 The substitution rate for ligand binding residues was significantly higher for branches leading to the acc-1 and mod-1 clades, where the convergent evolution for binding acetylcholine and serotonin, respectively, is thought to have occurred. Serotonin 188-197 Acetylcholine-gated chloride channel subunit acc-1 Caenorhabditis elegans 103-118 23739180-0 2013 TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. Serotonin 29-38 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 0-5 23739180-5 2013 Inhibition of TRPV4 with 0.5 muM HC-067047 significantly reduced the sensitivity of serotonin (5-HT)-induced contraction in wild-type (WT) PAs but had no effect on endothelin-1 or phenylephrine-activated response. Serotonin 84-93 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 14-19 24089222-3 2013 Piromelatine, a melatonin agonist, serotonin 5-HT-1A and 5-HT-1D agonist and serotonin 5-HT2B antagonist is a multimodal agent with sleep promoting, anti-diabetic, analgesic, anti-neurodegenerative, anxiolytic and antidepressant potential, currently in development for the treatment of insomnia. Serotonin 77-86 5-hydroxytryptamine receptor 2B Rattus norvegicus 87-93 23964727-6 2013 Serotonin, in turn, could bind to HTR1B receptors on osteoblasts and stop their proliferation by activating PKA and CREB.Although different groups have reported controversial results on the existence of an Lrp5-serotonin axis and the action of serotonin in bone remodeling, there is convincing evidence that serotonin modulators such as SSRIs can affect bone turnover. Serotonin 0-9 cAMP responsive element binding protein 1 Rattus norvegicus 116-120 23669068-6 2013 Using microdialysis experiments, we demonstrated that NOP-receptor activation by infusion of nociceptin 10(-6) M or 10(-5) M increased the level of extracellular serotonin in the dorsal raphe nucleus. Serotonin 162-171 prepronociceptin Rattus norvegicus 93-103 24265583-1 2013 In this study, we investigated the association between tryptophan hydroxylase-1 (TPH1 ) (218A>C), tryptophan hydroxylase-2 ( TPH2 ) (1463G>A) and serotonin carrier family 6, member 4 (SLC6A4) [long (L) vs. short (S)] gene polymorphisms with post-partum depression (PPD) in women from Jordan. Serotonin 152-161 tryptophan hydroxylase 1 Homo sapiens 55-79 23506877-2 2013 Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively). Serotonin 164-173 solute carrier family 18 member A3 Homo sapiens 69-76 23506877-2 2013 Members of the SLC18 family perform this function for acetylcholine (SLC18A3, the vesicular acetylcholine transporter or VAChT) and monoamines such as dopamine and serotonin (SLC18A1 and 2, the vesicular monoamine transporters VMAT1 and 2, respectively). Serotonin 164-173 solute carrier family 18 member A3 Homo sapiens 121-126 23355731-3 2013 5HT inhibited the LPS-induced release of proinflammatory cytokines without affecting IL-10 production, upregulated the expression of M2 polarization-associated genes (SERPINB2, THBS1, STAB1, COL23A1), and reduced the expression of M1-associated genes (INHBA, CCR2, MMP12, SERPINE1, CD1B, ALDH1A2). Serotonin 0-3 serpin family B member 2 Homo sapiens 167-175 23355731-3 2013 5HT inhibited the LPS-induced release of proinflammatory cytokines without affecting IL-10 production, upregulated the expression of M2 polarization-associated genes (SERPINB2, THBS1, STAB1, COL23A1), and reduced the expression of M1-associated genes (INHBA, CCR2, MMP12, SERPINE1, CD1B, ALDH1A2). Serotonin 0-3 serpin family E member 1 Homo sapiens 272-280 23355731-3 2013 5HT inhibited the LPS-induced release of proinflammatory cytokines without affecting IL-10 production, upregulated the expression of M2 polarization-associated genes (SERPINB2, THBS1, STAB1, COL23A1), and reduced the expression of M1-associated genes (INHBA, CCR2, MMP12, SERPINE1, CD1B, ALDH1A2). Serotonin 0-3 CD1b molecule Homo sapiens 282-286 23292797-4 2013 In this regard, we evaluate here the efficacy of Smo as it relates to the activation of G(i), by comparing Smo with the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor, a quintessential G(i)-coupled receptor. Serotonin 120-139 smoothened, frizzled class receptor Homo sapiens 49-52 23292797-4 2013 In this regard, we evaluate here the efficacy of Smo as it relates to the activation of G(i), by comparing Smo with the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor, a quintessential G(i)-coupled receptor. Serotonin 120-139 5-hydroxytryptamine receptor 1A Homo sapiens 145-163 23155177-8 2013 The GRP receptor antagonist enhanced scratching evoked by serotonin. Serotonin 58-67 gastrin releasing peptide Bos taurus 4-7 22386242-2 2012 Two serotonin derivatives (4 and 8) showed inhibitory effect of COX (1 and 2). Serotonin 4-13 mitochondrially encoded cytochrome c oxidase I Homo sapiens 64-76 20641293-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Serotonin 30-39 monoamine oxidase A Homo sapiens 0-5 22197914-5 2012 Additionally, the monoamine neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) levels involved in the antidepressant-like effect of HCE were also measured in the mice brain regions of frontal cortex and hippocampus. Serotonin 46-55 RNA guanylyltransferase and 5'-phosphatase Mus musculus 154-157 22308416-5 2012 Cultures from TPH(1)(-/-) in the presence of macrophage colony-stimulating factor and receptor activator for NF-KB ligand (RANKL) displayed fewer osteoclasts, and the decreased differentiation could be rescued by adding serotonin. Serotonin 220-229 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 123-128 22308416-6 2012 Our data also provide evidence that in the presence of RANKL, osteoclast precursors express TPH(1) and synthesize serotonin. Serotonin 114-123 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 55-60 22308416-8 2012 Our findings reveal that serotonin has an important local action in bone, as it can amplify the effect of RANKL on osteoclastogenesis. Serotonin 25-34 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 106-111 22257758-0 2012 Serotonin-mediated modulation of Na+/K+ pump current in rat hippocampal CA1 pyramidal neurons. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 72-75 22257758-1 2012 BACKGROUND: The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons. Serotonin 61-70 carbonic anhydrase 1 Rattus norvegicus 143-146 22257758-1 2012 BACKGROUND: The aim of this study was to investigate whether serotonin (5-hydroxytryptamine, 5-HT) can modulate Na+/K+ pump in rat hippocampal CA1 pyramidal neurons. Serotonin 72-91 carbonic anhydrase 1 Rattus norvegicus 143-146 22106156-10 2012 These results support a novel mechanism for serotonin stimulation of hepatic glycogenesis involving cdk5. Serotonin 44-53 cyclin dependent kinase 5 Homo sapiens 100-104 21990073-10 2012 This is the first report of HTR1A mutation underlying menstrual cycle-dependent febrile episodes, and implies that similar "febrile episode" cases may also result from the dysfunction of serotonin transmission. Serotonin 187-196 5-hydroxytryptamine receptor 1A Homo sapiens 28-33 22754301-1 2012 Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. Serotonin 68-77 tryptophan hydroxylase 1 Homo sapiens 26-30 23320133-7 2012 Serotonin hyperpolarizes entorhinal neurons and inhibits the excitatory synaptic transmission via activation of 5-HT(1A) receptors but facilitates GABA release via activation of 5-HT(2A) receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 112-119 23320133-8 2012 Both 5-HT(1A) and 5-HT(2A) receptors are required for serotonin-induced inhibition of epileptiform activity although 5-HT(3) receptors may be involved in serotonin-mediated inhibition of acetylcholine release in the EC. Serotonin 54-63 5-hydroxytryptamine receptor 1A Homo sapiens 5-12 22912839-0 2012 The effects of glycogen synthase kinase-3beta in serotonin neurons. Serotonin 49-58 glycogen synthase kinase 3 beta Mus musculus 15-45 22912839-2 2012 Increasing evidence has shown that GSK3 acts as a modulator in the serotonin neurotransmission system, including direct interaction with serotonin 1B (5-HT1B) receptors in a highly selective manner and prominent modulating effect on 5-HT1B receptor activity. Serotonin 67-76 glycogen synthase kinase 3 beta Mus musculus 35-39 22912839-6 2012 However, the expression of GSK3beta in snGSK3beta-KO mice was diminished in TpH2-expressing serotonin neurons. Serotonin 92-101 glycogen synthase kinase 3 beta Mus musculus 27-35 22912839-8 2012 The effect of anpirtoline on the horizontal, center, and vertical activities in the open field test was differentially affected by GSK3beta depletion in serotonin neurons, wherein vertical activity, but not horizontal activity, was significantly altered in snGSK3beta-KO mice. Serotonin 153-162 glycogen synthase kinase 3 beta Mus musculus 131-139 22912839-10 2012 Therefore, results of this study demonstrated a serotonin neuron-targeting function of GSK3beta by regulating 5-HT1B autoreceptors, which impacts serotonergic neuron firing, serotonin release, and serotonin-regulated behaviors. Serotonin 48-57 glycogen synthase kinase 3 beta Mus musculus 87-95 22912839-10 2012 Therefore, results of this study demonstrated a serotonin neuron-targeting function of GSK3beta by regulating 5-HT1B autoreceptors, which impacts serotonergic neuron firing, serotonin release, and serotonin-regulated behaviors. Serotonin 174-183 glycogen synthase kinase 3 beta Mus musculus 87-95 22912839-10 2012 Therefore, results of this study demonstrated a serotonin neuron-targeting function of GSK3beta by regulating 5-HT1B autoreceptors, which impacts serotonergic neuron firing, serotonin release, and serotonin-regulated behaviors. Serotonin 174-183 glycogen synthase kinase 3 beta Mus musculus 87-95 22253933-0 2012 Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury. Serotonin 75-84 solute carrier family 18 member A1 Rattus norvegicus 13-19 22253933-10 2012 Thus, transfection of VMAT-1 and TPH-1 induced vesicular storage of serotonin which is triggered release upon cooling and has protective effects against hypothermia. Serotonin 68-77 solute carrier family 18 member A1 Rattus norvegicus 22-28 22120177-5 2011 This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth factor beta1 (TGF-beta1), a powerful suppressor of hepatocyte proliferation, through signaling by mitogen-activated protein kinase 1 (ERK) and the transcription factor JunD. Serotonin 116-125 jun D proto-oncogene Mus musculus 345-349 21851826-8 2011 Inhibition of calcineurin activity by cyclosporine A or loss of NFATc2 protein by siRNA transfection abolished serotonin-induced cyclin A expression and consequent CDK2 activation and DNA synthesis. Serotonin 111-120 nuclear factor of activated T cells 2 Homo sapiens 64-70 21851826-9 2011 We further found that pretreatment of cells with sildenafil suppressed serotonin-triggered activation of calcineurin/NFATc2 signaling pathway and resultant cyclin A expression, CDK2 activation and cell proliferation, while the presence of DT-3 [a specific protein kinase G (PKG) peptide inhibitor] reversed the effects of sildenafil on PASMCs. Serotonin 71-80 nuclear factor of activated T cells 2 Homo sapiens 117-123 21851826-9 2011 We further found that pretreatment of cells with sildenafil suppressed serotonin-triggered activation of calcineurin/NFATc2 signaling pathway and resultant cyclin A expression, CDK2 activation and cell proliferation, while the presence of DT-3 [a specific protein kinase G (PKG) peptide inhibitor] reversed the effects of sildenafil on PASMCs. Serotonin 71-80 protein kinase cGMP-dependent 1 Homo sapiens 256-272 21851826-9 2011 We further found that pretreatment of cells with sildenafil suppressed serotonin-triggered activation of calcineurin/NFATc2 signaling pathway and resultant cyclin A expression, CDK2 activation and cell proliferation, while the presence of DT-3 [a specific protein kinase G (PKG) peptide inhibitor] reversed the effects of sildenafil on PASMCs. Serotonin 71-80 protein kinase cGMP-dependent 1 Homo sapiens 274-277 21699597-3 2011 Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library. Serotonin 140-144 Tryptophan hydroxylase Drosophila melanogaster 21-43 21699597-3 2011 Complementary DNA of tryptophan hydroxylase and phenylalanine-tryptophan hydroxylase, which convert tryptophan into 5-hydroxy-L-tryptophan (5-HTP), and that of aromatic L-amino acid decarboxylase, which converts 5-HTP into 5-HT, were isolated from a cricket brain cDNA library. Serotonin 140-144 Tryptophan hydroxylase Drosophila melanogaster 62-84 21636115-0 2011 Downregulation of basophil-derived IL-4 and in vivo T(H)2 IgE responses by serotonin and other organic cation transporter 3 ligands. Serotonin 75-84 interleukin 4 Mus musculus 35-39 21775495-5 2011 MAO A is a key enzyme that degrades a number of monoamine neurotransmitters, including serotonin. Serotonin 87-96 monoamine oxidase A Homo sapiens 0-5 21741252-1 2011 INTRODUCTION: [(18)F]Mefway is a serotonin 5-HT(1A) PET radiotracer with high specificity and favorable in vivo imaging properties. Serotonin 33-42 5-hydroxytryptamine receptor 1A Homo sapiens 43-50 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Serotonin 108-117 monoamine oxidase A Homo sapiens 0-19 21761555-1 2011 Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Serotonin 108-117 monoamine oxidase A Homo sapiens 21-25 21873959-4 2011 Pro-inflammatory cytokines, such as TNF-alpha, IL-1 and IL-6, stimulate central serotonin (5-HT) neurotransmission and are over-expressed in depression, which has been linked with hypothalamic-pituitary-adrenal axis (HPA) hyperactivity. Serotonin 80-89 interleukin 1 alpha Homo sapiens 47-51 21303932-11 2011 Serotonin and 17beta-estradiol increased CEBPbeta, CYP1B1, and FOS protein expression in PASMCs. Serotonin 0-9 CCAAT/enhancer binding protein (C/EBP), beta Mus musculus 41-49 21303932-11 2011 Serotonin and 17beta-estradiol increased CEBPbeta, CYP1B1, and FOS protein expression in PASMCs. Serotonin 0-9 FBJ osteosarcoma oncogene Mus musculus 63-66 21508359-0 2011 The effect of PTEN on serotonin synthesis and secretion from the carcinoid cell line BON. Serotonin 22-31 phosphatase and tensin homolog Homo sapiens 14-18 21508359-2 2011 The purpose of this study was to investigate the relationship between the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome ten) and serotonin synthesis and secretion in the carcinoid cancer cell line BON. Serotonin 210-219 protein tyrosine kinase 2 beta Homo sapiens 104-120 21508359-2 2011 The purpose of this study was to investigate the relationship between the phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt) inhibitor PTEN (phosphatase and tensin homolog deleted on chromosome ten) and serotonin synthesis and secretion in the carcinoid cancer cell line BON. Serotonin 210-219 phosphatase and tensin homolog Homo sapiens 142-146 21508359-3 2011 MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. Serotonin 118-127 phosphatase and tensin homolog Homo sapiens 23-27 21508359-3 2011 MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. Serotonin 207-216 phosphatase and tensin homolog Homo sapiens 23-27 21508359-3 2011 MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. Serotonin 207-216 tryptophan hydroxylase 1 Homo sapiens 146-170 21508359-3 2011 MATERIALS AND METHODS: PTEN was inhibited by pharmacological and molecular approaches, and the resultant secretion of serotonin and expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, was assessed. Serotonin 207-216 tryptophan hydroxylase 1 Homo sapiens 172-176 21508359-4 2011 RESULTS: Inhibition of PTEN in vitro, with concomitant increased Akt signaling, resulted in decreased secretion of serotonin, as well as decreased serotonin synthesis, as confirmed by reduced expression of TPH1. Serotonin 115-124 phosphatase and tensin homolog Homo sapiens 23-27 21508359-4 2011 RESULTS: Inhibition of PTEN in vitro, with concomitant increased Akt signaling, resulted in decreased secretion of serotonin, as well as decreased serotonin synthesis, as confirmed by reduced expression of TPH1. Serotonin 147-156 phosphatase and tensin homolog Homo sapiens 23-27 21508359-5 2011 Inhibition of PTEN in BON cells in an animal model resulted in decreased serum serotonin. Serotonin 79-88 phosphatase and tensin homolog Homo sapiens 14-18 21508359-6 2011 CONCLUSION: By inhibiting signaling through Akt, PTEN indirectly promotes serotonin synthesis and secretion. Serotonin 74-83 phosphatase and tensin homolog Homo sapiens 49-53 21236359-0 2011 Ceramide induces serotonin release from RBL-2H3 mast cells through calcium mediated activation of phospholipase A2. Serotonin 17-26 phospholipase A2 group IB Rattus norvegicus 98-114 21236359-4 2011 Moreover, cytosolic PLA(2) GIVA (cPLA(2) GIVA) siRNA-transfected RBL-2H3 cells showed a lower level of serotonin release than scramble siRNA-transfected cells. Serotonin 103-112 phospholipase A2 group IB Rattus norvegicus 20-26 21256578-4 2011 DA-8031 exhibits high affinity and selectivity to the serotonin transporter (Ki value 1.94 nM for 5-hydroxytryptamine transporter, 22 020 nM for norepinephrine transporter, and 77 679 nM for dopamine transporter) and potency to inhibit serotonin reuptake into the rat brain synaptosome in vitro (half maximal inhibitory concentration 6.52 nM for 5-hydroxytryptamine, 30.2 muM for norepinephrine, and 136.9 muM for dopamine). Serotonin 54-63 solute carrier family 6 member 2 Rattus norvegicus 145-171 21302344-2 2011 Well-characterized common functional polymorphisms in the genes MAOA, COMT, and 5HTTLPR each have predictable effects on the availability of the monoamine neurotransmitters dopamine, noradrenaline, and serotonin. Serotonin 202-211 monoamine oxidase A Homo sapiens 64-68 21073637-2 2011 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: TPH1 and TPH2. Serotonin 80-89 tryptophan hydroxylase 1 Homo sapiens 112-116 21252298-10 2011 Mutant analysis further showed that lateral root induction elicited by serotonin was independent of the AUX1 and AXR4 loci but required AXR1 and AXR2. Serotonin 71-80 indole-3-acetic acid 7 Arabidopsis thaliana 145-149 21129446-1 2011 Norepinephrine and serotonin involvement in nociceptive functions is supported by observations of analgesic effects of norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitors such as amitriptyline. Serotonin 19-28 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 119-145 20528162-6 2011 We identified a strong expression of the serotonin transporter and confirmed the high-affinity serotonin transporter-mediated uptake of serotonin (5-HT), along with uptake via the norepinephrine transporter, and an evidence of 5-HT breakdown due to the expression of the degradative enzymes monoamine oxidase A and B. Serotonin 41-50 monoamine oxidase A Homo sapiens 291-316 20649486-4 2011 Clones expressing Lmx1b at a low level showed increased neurogenesis and elevated production of neurons expressing serotonin, serotonin transporter, tryptophan hydroxylase 2, and transcription factor Pet1, the landmarks of serotonergic differentiation. Serotonin 115-124 LIM homeobox transcription factor 1 beta Homo sapiens 18-23 20649486-9 2011 Together, our results demonstrate the capacity of Lmx1b to specify a serotonin neurotransmitter phenotype when overexpressed in mES cell-derived NPs. Serotonin 69-78 LIM homeobox transcription factor 1 beta Homo sapiens 50-55 20674511-10 2011 Calbindin immunoreactivity colocalised to a large extent with serotonin immunoreactivity, but not with choline acetyltransferase (ChAT)-immunoreactivity. Serotonin 62-71 calbindin 1 Homo sapiens 0-9 21376255-9 2011 CONCLUSIONS: Overexpression of S100B in the brain resulted in motor coordination impairment, which may have resulted from the downregulation of D2DR and GRK2 expressions, increased DA synthesis and metabolism, and decreased 5-HT level. Serotonin 224-228 S100 protein, beta polypeptide, neural Mus musculus 31-36 20580984-7 2010 The results suggest that TPH1 gene variation participates in the regulation of serotonin and dopamine turnover rates in the central nervous system of healthy human subjects. Serotonin 79-88 tryptophan hydroxylase 1 Homo sapiens 25-29 21209909-11 2010 CONCLUSIONS AND SIGNIFICANCE: Transplantation and short-term survival of Ngn2-expressing hENPs restore weight support after SCI and partially restore serotonin fibers density and 5HT1A receptor pattern caudal to the lesion. Serotonin 150-159 neurogenin 2 Homo sapiens 73-77 21068324-0 2010 Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun. Serotonin 22-31 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 84-112 20204405-1 2010 PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression. Serotonin 116-125 monoamine oxidase A Homo sapiens 23-42 20204405-1 2010 PURPOSE: Inhibitors of monoamine oxidase A (MAOA), a mitochondrial enzyme that degrades neurotransmitters including serotonin and norepinephrine, are commonly used to treat neurological conditions including depression. Serotonin 116-125 monoamine oxidase A Homo sapiens 44-48 20592246-7 2010 Under both neutral (pH 7.4) and acidic (pH 6.6) conditions, adenosine is transported by PMAT at an efficiency (V(max)/K(m)) at least 10-fold lower than that of the organic cation substrates 1-methyl-4-phenylpyridinium and serotonin. Serotonin 222-231 solute carrier family 29 member 4 Homo sapiens 88-92 20695778-6 2010 However, cat-1 and cat-2 mutants, which are respectively defective in serotonin and dopamine secretion and dopamine secretion only, showed no enhancement of the chemotactic response to sodium acetate, even when pre-exposed to this chemical. Serotonin 70-79 BH4_AAA_HYDROXYL_2 domain-containing protein;Tyrosine 3-hydroxylase;Tyrosine 3-monooxygenase Caenorhabditis elegans 19-24 20477771-3 2010 ANX/DEP ALC may be related to dopamine and serotonin, which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 43-52 monoamine oxidase A Homo sapiens 77-96 20477771-3 2010 ANX/DEP ALC may be related to dopamine and serotonin, which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 43-52 monoamine oxidase A Homo sapiens 98-102 20576032-0 2010 Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer"s disease. Serotonin 0-9 carbonic anhydrase 1 Mus musculus 88-91 20576032-0 2010 Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer"s disease. Serotonin 42-51 carbonic anhydrase 1 Mus musculus 88-91 20534837-4 2010 Food or serotonin sensitize the ASHs and stimulate aversive responses through a pathway requiring the release of nlp-3-encoded neuropeptides from the ASHs. Serotonin 8-17 Neuropeptide-Like Protein Caenorhabditis elegans 113-118 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Serotonin 52-61 monoamine oxidase A Homo sapiens 0-19 20332182-1 2010 Monoamine oxidase A (MAOA) and the transporters for serotonin (5-HTT) and norepinephrine (NET) may play important roles in regulating maternal monoamine neurotransmitters transferred across the placenta to the fetus. Serotonin 52-61 monoamine oxidase A Homo sapiens 21-25 20463306-7 2010 Also, for the first time we demonstrate that these ESC-derived serotonin neurons exhibit functional high-affinity transporter sites, as well as high-affinity 5HT(1A) binding sites, which are essential targets of common psychoactive drugs. Serotonin 63-72 5-hydroxytryptamine receptor 1A Homo sapiens 158-164 20177707-1 2010 We previously demonstrated that tryptophan hydroxylase (TPH), the rate-limiting enzyme of serotonin (5-HT) synthesis, was commonly present in the brains of some insects. Serotonin 90-99 Tryptophan hydroxylase Drosophila melanogaster 32-54 20177707-1 2010 We previously demonstrated that tryptophan hydroxylase (TPH), the rate-limiting enzyme of serotonin (5-HT) synthesis, was commonly present in the brains of some insects. Serotonin 90-99 Tryptophan hydroxylase Drosophila melanogaster 56-59 19933401-3 2010 We have uncovered a novel regulatory mechanism whereby p90 ribosomal S6 kinase 2 (RSK2) interacts with 5-hydroxytryptamine(2A) (5-HT(2A)) serotonin receptors and attenuates receptor signaling via direct receptor phosphorylation (Proc Natl Acad Sci U S A 103:4717-4722, 2006; J Biol Chem 284:5557-5573, 2009). Serotonin 103-122 ribosomal protein S6 kinase polypeptide 3 Mus musculus 82-86 32987057-6 2021 Hence, here we are exploring the role of 5-HT in memory retrieval by using its metabolic precursor L-tryptophan and several ligands at 5-HT1A and 5-HT7 receptors. Serotonin 41-45 5-hydroxytryptamine receptor 1A Homo sapiens 135-141 20337188-9 2010 The serotonin metabolism in the CSF was reduced, and the serum melatonin profile was flat, while cortisol and core temperature profiles were normal. Serotonin 4-13 colony stimulating factor 2 Homo sapiens 32-35 20133677-4 2010 NAS, a precursor of melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). Serotonin 50-59 arylalkylamine N-acetyltransferase Mus musculus 63-68 33390474-6 2021 We previously revealed that several antiepileptic drugs, serotonin 5-HT1A receptor agonists, plant-derived chemicals (phytochemicals) increased xCT expression, Nrf2 activation, GSH or MT expression and release in/from astrocytes, and exerted a neuroprotective effect against dopaminergic neurodegeneration in Parkinson"s disease model. Serotonin 57-66 5-hydroxytryptamine receptor 1A Homo sapiens 67-82 20133677-4 2010 NAS, a precursor of melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). Serotonin 50-59 arylalkylamine N-acetyltransferase Mus musculus 70-104 19890267-1 2010 Reversible inhibitors of monoamine oxidase-A (RIMA) inhibit the breakdown of three major neurotransmitters, serotonin, norepinephrine and dopamine, offering a multi-neurotransmitter strategy for the treatment of depression. Serotonin 108-117 monoamine oxidase A Homo sapiens 25-44 20204739-4 2010 Synthesis of serotonin can occur in pulmonary artery endothelial cells by the enzyme tryptophan hydroxylase 1 (TPH1). Serotonin 13-22 tryptophan hydroxylase 1 Homo sapiens 85-109 33390474-6 2021 We previously revealed that several antiepileptic drugs, serotonin 5-HT1A receptor agonists, plant-derived chemicals (phytochemicals) increased xCT expression, Nrf2 activation, GSH or MT expression and release in/from astrocytes, and exerted a neuroprotective effect against dopaminergic neurodegeneration in Parkinson"s disease model. Serotonin 57-66 solute carrier family 7 member 11 Homo sapiens 144-147 20204739-4 2010 Synthesis of serotonin can occur in pulmonary artery endothelial cells by the enzyme tryptophan hydroxylase 1 (TPH1). Serotonin 13-22 tryptophan hydroxylase 1 Homo sapiens 111-115 33383868-7 2020 Furthermore, we disclose that the serotonin/5-HT1A signaling enhances endothelial CLDN5 expression in BMVECs under two-dimensional co-culture conditions. Serotonin 34-43 5-hydroxytryptamine receptor 1A Homo sapiens 44-50 33424630-13 2020 Conclusion: Disruptions of the intestinal flora structure due to oral administration of penicillin may significantly increase serum 5-HT level and inhibit intestinal motility, at least partially through up-regulating the expression of HCN2. Serotonin 132-136 hyperpolarization-activated, cyclic nucleotide-gated K+ 2 Mus musculus 235-239 22615590-0 2010 Formalin pain increases the concentration of serotonin and its 5-hydroxyindoleacetic acid metabolite in the CA1 region of hippocampus. Serotonin 45-54 carbonic anhydrase 1 Rattus norvegicus 108-111 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 70-79 tryptophan hydroxylase 1 Homo sapiens 0-24 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 70-79 tryptophan hydroxylase 1 Homo sapiens 26-30 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 172-181 tryptophan hydroxylase 1 Homo sapiens 0-24 20329492-2 2010 Tryptophan hydroxylase 1 (TPH1) is the limiting enzyme for peripheral serotonin synthesis, and its expression by valve interstitial cells (IC) could implicate an autocrine serotonin signaling mechanism in primary degenerative myxomatous mitral valve disease. Serotonin 172-181 tryptophan hydroxylase 1 Homo sapiens 26-30 33362253-2 2020 GNAT enzymes transfer an acyl moiety from acyl coenzyme A to a wide range of substrates including aminoglycosides, serotonin, glucosamine-6-phosphate, protein N-termini and lysine residues of histones and other proteins. Serotonin 115-124 glycine-N-acyltransferase like 1 Homo sapiens 0-4 20184120-0 2010 [Effect of serotonin on the formation of neurons producing gonadotropin-releasing hormone in Wistar rats]. Serotonin 11-20 gonadotropin releasing hormone 1 Rattus norvegicus 59-89 20184120-1 2010 The effect of serotonin on the formation of neurons producing gonadotropin-releasing hormone (GnRH) during embryogenesis of Wistar rats was studied. Serotonin 14-23 gonadotropin releasing hormone 1 Rattus norvegicus 62-92 20184120-1 2010 The effect of serotonin on the formation of neurons producing gonadotropin-releasing hormone (GnRH) during embryogenesis of Wistar rats was studied. Serotonin 14-23 gonadotropin releasing hormone 1 Rattus norvegicus 94-98 20184120-2 2010 The neurons producing GnRH were detected immunocytochemically on days 18 and 21 of embryonic development and on day 15 of postnatal development of rats with normal serotonin metabolism and rats in which the synthesis of serotonin was inhibited by p-chlorophenylalanine. Serotonin 164-173 gonadotropin releasing hormone 1 Rattus norvegicus 22-26 20184120-2 2010 The neurons producing GnRH were detected immunocytochemically on days 18 and 21 of embryonic development and on day 15 of postnatal development of rats with normal serotonin metabolism and rats in which the synthesis of serotonin was inhibited by p-chlorophenylalanine. Serotonin 220-229 gonadotropin releasing hormone 1 Rattus norvegicus 22-26 20184120-8 2010 Thus, serotonin inhibits the proliferation of GnRH neuron progenitor cells and thereby has a morphogenetic effect on the development of these neurons. Serotonin 6-15 gonadotropin releasing hormone 1 Rattus norvegicus 46-50 32454163-8 2020 MAO-A inhibitors prevent neurotransmitter breakdown and increase dopamine and serotonin concentrations in the brain. Serotonin 78-87 monoamine oxidase A Homo sapiens 0-5 19844076-0 2010 Sequence variants in BMPR2 and genes involved in the serotonin and nitric oxide pathways in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: relation to clinical parameters and comparison with left heart disease. Serotonin 53-62 bone morphogenetic protein receptor type 2 Homo sapiens 21-26 19812368-5 2009 ROS production and the suppression of Cdc42GAP activity in response to stimulation with 5-hydroxytryptamine (5-HT) were attenuated in cells producing p47(phox) shRNA compared with cells producing luciferase shRNA. Serotonin 88-107 inhibitor of growth family member 1 Homo sapiens 150-153 33007358-6 2020 Some 5-HT receptors are still the object of numerous investigations including 5-HT1A, 5-HT2A, and 5-HT6 receptor subtypes. Serotonin 5-9 5-hydroxytryptamine receptor 1A Homo sapiens 78-84 19467322-2 2009 However, the role of VGLUT3-containing axons in modulating activity of serotonin (5-HT) neurons within the DR remains poorly understood. Serotonin 71-80 solute carrier family 17 member 8 Homo sapiens 21-27 32967429-6 2020 The mRNA of the rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase 1 was unregulated. Serotonin 40-49 tryptophan hydroxylase 1 Homo sapiens 61-85 19105200-2 2009 The norepinephrine transporter (NET; SLC6A2) and the serotonin (5-HT)(1A) receptor (5-HT(1A) receptor; HTR1A) play an important role in central nervous monoaminergic homeostasis. Serotonin 53-62 5-hydroxytryptamine receptor 1A Homo sapiens 84-101 19105200-2 2009 The norepinephrine transporter (NET; SLC6A2) and the serotonin (5-HT)(1A) receptor (5-HT(1A) receptor; HTR1A) play an important role in central nervous monoaminergic homeostasis. Serotonin 53-62 5-hydroxytryptamine receptor 1A Homo sapiens 103-108 32812654-8 2020 We found that the serum level of both CRH and 5-HT was significantly correlated with EPDS score; the AUC for CRH was 0.79, and 5-HT was 0.85, which indicated that both CRH and 5-HT are a reliable biomarker for PPD. Serotonin 127-131 corticotropin releasing hormone Homo sapiens 38-41 19666839-10 2009 Addition of serotonin to recombinant human MAO-A generated (O2*.-), and this effect was prevented by an MAO inhibitor. Serotonin 12-21 monoamine oxidase A Homo sapiens 43-48 19666839-11 2009 In conclusion, we have identified a novel mechanism whereby MAO-A can contribute to increased oxidative stress in human heart valves and pulmonary artery exposed to serotonin and dopamine. Serotonin 165-174 monoamine oxidase A Homo sapiens 60-65 32812654-8 2020 We found that the serum level of both CRH and 5-HT was significantly correlated with EPDS score; the AUC for CRH was 0.79, and 5-HT was 0.85, which indicated that both CRH and 5-HT are a reliable biomarker for PPD. Serotonin 127-131 corticotropin releasing hormone Homo sapiens 38-41 19614678-6 2009 The effect of Abeta is mediated by G-protein coupled receptors, neuropeptide Y1 (NPY1R) and serotonin (5-hydroxytryptamine) receptor 2B, via phosphatidylinositol-3-OH kinase-dependent activation of the MAPK/ERK1/2. Serotonin 92-101 amyloid beta (A4) precursor protein Mus musculus 14-19 19614678-6 2009 The effect of Abeta is mediated by G-protein coupled receptors, neuropeptide Y1 (NPY1R) and serotonin (5-hydroxytryptamine) receptor 2B, via phosphatidylinositol-3-OH kinase-dependent activation of the MAPK/ERK1/2. Serotonin 103-122 amyloid beta (A4) precursor protein Mus musculus 14-19 32842837-12 2020 CONCLUSION: RGS12 is a critical modulator of serotonergic neurotransmission and serotonergically modulated behavior in mice; lack of hyperlocomotion to low dose MDMA in RGS12-null mice is related to an alteration of steady-state SERT expression and 5-HT uptake. Serotonin 249-253 regulator of G-protein signaling 12 Mus musculus 12-17 33184794-4 2021 Recently, selective serotonin recapture inhibitors including sertraline and citalopram were shown to inhibit TLR-3 activity, but the direct effects of these antidepressant drugs on the gut mucosa barrier remain largely unexplored. Serotonin 20-29 toll-like receptor 3 Rattus norvegicus 109-114 19619137-7 2009 Further, inhibition of monoamine oxidase A prevents the degradation of serotonin in bipolar neurons, suggesting that monoamine oxidase A is present in these neurons. Serotonin 71-80 monoamine oxidase A Homo sapiens 23-42 19619137-7 2009 Further, inhibition of monoamine oxidase A prevents the degradation of serotonin in bipolar neurons, suggesting that monoamine oxidase A is present in these neurons. Serotonin 71-80 monoamine oxidase A Homo sapiens 117-136 19560507-1 2009 BACKGROUND: Four serotonin-related genes including guanine nucleotide binding protein beta polypeptide 3 (GNB3), 5-hydroxytryptamine receptor 1A (HTR1A; serotonin receptor 1A), 5-hydroxytryptamine receptor 2A (HTR2A; serotonin receptor 2A), and solute carrier family 6 member 4 (SLC6A4; serotonin neurotransmitter transporter) have been suggested to be candidate genes for influencing antidepressant treatment outcome. Serotonin 17-26 G protein subunit beta 3 Homo sapiens 51-104 19560507-1 2009 BACKGROUND: Four serotonin-related genes including guanine nucleotide binding protein beta polypeptide 3 (GNB3), 5-hydroxytryptamine receptor 1A (HTR1A; serotonin receptor 1A), 5-hydroxytryptamine receptor 2A (HTR2A; serotonin receptor 2A), and solute carrier family 6 member 4 (SLC6A4; serotonin neurotransmitter transporter) have been suggested to be candidate genes for influencing antidepressant treatment outcome. Serotonin 17-26 G protein subunit beta 3 Homo sapiens 106-110 19560507-1 2009 BACKGROUND: Four serotonin-related genes including guanine nucleotide binding protein beta polypeptide 3 (GNB3), 5-hydroxytryptamine receptor 1A (HTR1A; serotonin receptor 1A), 5-hydroxytryptamine receptor 2A (HTR2A; serotonin receptor 2A), and solute carrier family 6 member 4 (SLC6A4; serotonin neurotransmitter transporter) have been suggested to be candidate genes for influencing antidepressant treatment outcome. Serotonin 17-26 5-hydroxytryptamine receptor 1A Homo sapiens 113-144 19560507-1 2009 BACKGROUND: Four serotonin-related genes including guanine nucleotide binding protein beta polypeptide 3 (GNB3), 5-hydroxytryptamine receptor 1A (HTR1A; serotonin receptor 1A), 5-hydroxytryptamine receptor 2A (HTR2A; serotonin receptor 2A), and solute carrier family 6 member 4 (SLC6A4; serotonin neurotransmitter transporter) have been suggested to be candidate genes for influencing antidepressant treatment outcome. Serotonin 17-26 5-hydroxytryptamine receptor 1A Homo sapiens 146-151 23123701-1 2013 The phenethylamine and indoleamine classes of hallucinogens demonstrate distinct pharmacological properties, although they share a serotonin(2A) (5-HT(2A)) receptor mechanism of action (MOA). Serotonin 131-140 5-hydroxytryptamine receptor 2A Oryctolagus cuniculus 146-164 23018753-6 2013 These results argue for a mechanism of lowering extracellular serotonin in the prefrontal and anterior cingulate cortex, consequent to elevated MAO-A level. Serotonin 62-71 monoamine oxidase A Homo sapiens 144-149 23089803-4 2013 Glucuronidation of endogenous neurotransmitter serotonin was catalyzed by Ugt1a6b with k(cat)/K(m) (4.5 M(-1) s(-1)) slightly higher than that of Ugt1a6a (2.4 M(-1) s(-1)). Serotonin 47-56 UDP glucuronosyltransferase 1 family, polypeptide A6B Mus musculus 74-81 23089803-7 2013 Our new findings indicate that Ugt1a6a and Ugt1a6b play different roles in mice, driven by differences in expression and kinetic properties for serotonin glucuronidation. Serotonin 144-153 UDP glucuronosyltransferase 1 family, polypeptide A6B Mus musculus 43-50 19772578-1 2009 BACKGROUND: We previously reported risk haplotypes for two genes related with serotonin and dopamine metabolism: MAOA in migraine without aura and DDC in migraine with aura. Serotonin 78-87 monoamine oxidase A Homo sapiens 113-117 33177592-8 2020 In addition, the total brain serotonin levels were significantly increased in AS- and Kiss1-treated groups as compared to control and morphine treated group. Serotonin 29-38 KiSS-1 metastasis suppressor Danio rerio 86-91 19744316-3 2009 Notch signalling regulates expression of TPH1, the rate limiting enzyme in the biosynthesis of serotonin. Serotonin 95-104 tryptophan hydroxylase 1 Homo sapiens 41-45 19827295-1 2009 A series of 4-substituted piperazine derivatives bearing a norbornene nucleus have been prepared and their affinity for serotonin 5-HT1A, 5-HT2A and 5-HT2C receptors has been evaluated. Serotonin 120-129 5-hydroxytryptamine receptor 1A Homo sapiens 130-136 24553000-1 2013 This article focuses on recent research on the cytochrome P450 2D (CYP2D) catalyzed synthesis of the monoaminergic neurotransmitters dopamine and serotonin in the brain and on the influence of psychotropic drugs on the activity of brain CYP2D. Serotonin 146-155 cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) Homo sapiens 47-65 24553000-1 2013 This article focuses on recent research on the cytochrome P450 2D (CYP2D) catalyzed synthesis of the monoaminergic neurotransmitters dopamine and serotonin in the brain and on the influence of psychotropic drugs on the activity of brain CYP2D. Serotonin 146-155 cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) Homo sapiens 67-72 24553000-1 2013 This article focuses on recent research on the cytochrome P450 2D (CYP2D) catalyzed synthesis of the monoaminergic neurotransmitters dopamine and serotonin in the brain and on the influence of psychotropic drugs on the activity of brain CYP2D. Serotonin 146-155 cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) Homo sapiens 237-242 33177592-9 2020 These results suggest that habenular Kiss1 might be involved in consolidation or retrieval of fear memory through the serotonin system. Serotonin 118-127 KiSS-1 metastasis suppressor Danio rerio 37-42 24553000-2 2013 Recent in vitro and in vivo studies performed in rodents indicate that dopamine and serotonin may be formed in the brain via alternative CYP2D-mediated pathways, i.e., tyramine hydroxylation and 5-methoxytryptamine O-demethylation, respectively. Serotonin 84-93 cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) Homo sapiens 137-142 32913022-2 2020 Serotonin signaling through a subset of serotonin receptors suppresses Abeta generation. Serotonin 0-9 amyloid beta (A4) precursor protein Mus musculus 71-76 22836370-1 2013 RATIONALE: The serotonin (5-HT) system is involved in pain modulation, and 5-HT receptor agonists can enhance antinociceptive effects of mu opioid receptor agonists. Serotonin 15-24 opioid receptor mu 1 Macaca mulatta 137-155 19524439-2 2009 The serotonin derivatives such as N-caffeoylserotonin (3) and N-protocatechuoylserotonin (9) were inhibitory to tyrosinase from mouse B16 and human HMV-II melanoma cells, while the corresponding derivatives of tryptamine and 5-methoxytryptamine were almost inactive or less active than the serotonin derivatives. Serotonin 4-13 tyrosinase Mus musculus 112-122 19564617-3 2009 We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1. Serotonin 218-227 endothelin 1 Mus musculus 349-361 19564617-3 2009 We provide evidence that at least 3 different molecular pathways contribute to the transduction of itch responses to different pruritogens: 1) histamine requires the function of both PLCbeta3 and the TRPV1 channel; 2) serotonin, or a selective agonist, alpha-methyl-serotonin (alpha-Me-5-HT), requires the presence of PLCbeta3 but not TRPV1, and 3) endothelin-1 (ET-1) does not require either PLCbeta3 or TRPV1. Serotonin 218-227 endothelin 1 Mus musculus 363-367 32913022-2 2020 Serotonin signaling through a subset of serotonin receptors suppresses Abeta generation. Serotonin 40-49 amyloid beta (A4) precursor protein Mus musculus 71-76 32913022-3 2020 We proposed that escitalopram, the most specific selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter , SERT, would suppress Abeta levels in mice. Serotonin 59-68 amyloid beta (A4) precursor protein Mus musculus 158-163 19470879-3 2009 We found that the beta(2)-adrenoceptor antagonist ICI 118,551 (ICI) evoked a decrease of vascular tone in large pulmonary arteries and reduced the sensitivity of pulmonary arteries toward different contracting agents, eg, norepinephrine, serotonin, or endothelin. Serotonin 238-247 adrenergic receptor, beta 2 Mus musculus 18-38 23152612-0 2012 IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway. Serotonin 82-91 Inward rectifier potassium channel irk-1 Caenorhabditis elegans 0-5 32913022-3 2020 We proposed that escitalopram, the most specific selective serotonin reuptake inhibitor (SSRI) that inhibits the serotonin transporter , SERT, would suppress Abeta levels in mice. Serotonin 113-122 amyloid beta (A4) precursor protein Mus musculus 158-163 32667794-3 2020 In this current study, the potentials of alpha-lactalbumin (ALA), a tryptophan rich dietary protein acting as a precursor of neurotransmitter serotonin, to promote the burn wound healing and reduce the scar formation were investigated. Serotonin 142-151 lactalbumin, alpha Rattus norvegicus 41-58 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Serotonin 182-191 monoamine oxidase A Homo sapiens 61-66 22826345-0 2012 Selective deletion of forebrain glycogen synthase kinase 3beta reveals a central role in serotonin-sensitive anxiety and social behaviour. Serotonin 89-98 glycogen synthase kinase 3 beta Mus musculus 32-62 22579773-2 2012 Although the mechanism underlying the appearance of GID is unknown, in a recent clinical study the partial 5-HT(1A) agonist buspirone was found to markedly reduce GID in three grafted patients, who showed significant serotonin (5-HT) hyperinnervation in the grafted striatum in positron emission tomography scanning (Politis et al., 2010, 2011). Serotonin 217-226 5-hydroxytryptamine receptor 1A Homo sapiens 107-114 19506905-5 2009 Indeed, a series of recent studies, particularly concentrating on the serotonin and norepinephrine metabolising enzyme, monoamine oxidase A, has emphasised the necessity of examining gene by environmental interactions if the contributions of individual loci are to be understood. Serotonin 70-79 monoamine oxidase A Homo sapiens 120-139 19302089-1 2009 BACKGROUND: Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 61-70 monoamine oxidase A Homo sapiens 94-113 19302089-1 2009 BACKGROUND: Antisocial alcoholism is related to dopamine and serotonin which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 61-70 monoamine oxidase A Homo sapiens 115-119 19194374-10 2009 Monoamines such as noradrenalin and serotonin may modulate these relationships, given that their metabolism varies according to MAOA variants, and that they modulate both emotional brain systems and antisocial aggression. Serotonin 36-45 monoamine oxidase A Homo sapiens 128-132 32615138-0 2020 Improvement of lower urinary tract function by a selective serotonin 5-HT1A receptor agonist, NLX-112, after chronic spinal cord injury. Serotonin 59-68 5-hydroxytryptamine receptor 1A Homo sapiens 69-84 19145225-1 2009 Certain polymorphisms reduce serotonin (5-HT) reuptake transporter (5-HTT) function and increase susceptibility to psychiatric disorders. Serotonin 29-38 huntingtin Mus musculus 70-73 32711369-4 2020 Because serotonin is involved in the development of the HPG axis which is required for puberty establishment, serotonin could also alter expression patterns of for instance the estrogen receptor alpha (ERalpha). Serotonin 110-119 estrogen receptor 1 Rattus norvegicus 202-209 19418633-0 2009 Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor. Serotonin 14-23 prepronociceptin Rattus norvegicus 35-45 22759908-3 2012 Serotonin neurons, included into the dopaminergic cell suspension due to the nature of the dissection process, have been suggested as a key factor for the development of GID, since the administration of the serotonin (5-HT)(1A)-receptor agonist buspirone reduced dyskinesia in transplanted PD patients. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 218-236 22759908-3 2012 Serotonin neurons, included into the dopaminergic cell suspension due to the nature of the dissection process, have been suggested as a key factor for the development of GID, since the administration of the serotonin (5-HT)(1A)-receptor agonist buspirone reduced dyskinesia in transplanted PD patients. Serotonin 207-216 5-hydroxytryptamine receptor 1A Homo sapiens 218-236 22609378-5 2012 Interestingly, the evoked release of [(14)C]glutamate and [(3)H]serotonin was significantly greater in the CB(1)R knockout CD-1 mice. Serotonin 64-73 CD1 antigen complex Mus musculus 123-127 19418633-0 2009 Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor. Serotonin 14-23 prepronociceptin Rattus norvegicus 46-56 32961761-8 2020 The experiments in B16F10 cells show that 5-HT promotes melanin synthesis by up-regulating the expression of key proteins MITF, TYR, TRP-1, and TRP-2. Serotonin 42-46 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 133-138 32961761-8 2020 The experiments in B16F10 cells show that 5-HT promotes melanin synthesis by up-regulating the expression of key proteins MITF, TYR, TRP-1, and TRP-2. Serotonin 42-46 tRNA proline 2 Mus musculus 144-149 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase A Homo sapiens 5-24 32942346-2 2020 Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist with serotonin 5-HT1A receptor partial agonist and serotonin 5-HT2A antagonist properties, is approved to treat manic and depressive episodes of bipolar disorder. Serotonin 74-83 5-hydroxytryptamine receptor 1A Homo sapiens 84-99 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase A Homo sapiens 26-31 22412189-3 2012 This study examines the effect of escitalopram (CIT) administration to SS and SR monkeys on corticotrophin-releasing factor (CRF) receptor 1 (CRF-R1) and CRF receptor 2 (CRF-R2) gene expression in the serotonin cell body region of the midbrain dorsal raphe. Serotonin 201-210 corticotropin releasing hormone receptor 2 Homo sapiens 170-176 19334715-1 2009 Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer"s disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). Serotonin 0-9 amyloid beta (A4) precursor protein Mus musculus 225-230 19334715-1 2009 Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer"s disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). Serotonin 28-32 amyloid beta (A4) precursor protein Mus musculus 225-230 32330588-7 2020 Alcohol-induced changes in BDNF and 5-HT systems were revealed in the raphe nuclei area where the majority of the cell bodies of the 5-HT neurons are localized, as well as in the cortex, hippocampus and amygdala. Serotonin 133-137 brain derived neurotrophic factor Mus musculus 27-31 18848359-7 2009 Six polymorphisms in the four serotonin-related genes (5-HTT, 5-HTR1A, 5-HTR1B and 5-HTR2A) were selected to detect. Serotonin 30-39 5-hydroxytryptamine receptor 1A Homo sapiens 64-69 22365943-4 2012 Patients who lack both MAOA and MAOB have the most extreme laboratory values (urine, blood, and CSF serotonin 4-6 times normal, with elevated O-methylated amine metabolites and reduced deaminated metabolites) in addition to severe intellectual deficiency and behavioral problems. Serotonin 100-109 monoamine oxidase A Homo sapiens 23-27 32330588-8 2020 Our data allow suggesting that BDNF/5-HT interaction contribute to the mechanism underlying chronic alcohol-induced neurodegenerative disorders. Serotonin 36-40 brain derived neurotrophic factor Mus musculus 31-35 32590336-7 2020 IDO and TDO are especially of interest in NETs since some tumours produce serotonin but the majority do not, which potentially deplete the precursor tryptophan. Serotonin 74-83 indoleamine 2,3-dioxygenase 1 Homo sapiens 0-3 22428927-6 2012 The upregulation was partially suppressed by treatment with 5-HT2A agonists (serotonin and alpha-Me-5-HT), suggesting that safflomide may upregulate adiponectin expression more than by blocking 5-HT2A receptors in 3T3-L1 cells. Serotonin 77-86 adiponectin, C1Q and collagen domain containing Mus musculus 149-160 32459080-0 2020 Key role of the 5-HT1A receptor addressing protein Yif1B in serotonin neurotransmission and SSRI treatment. Serotonin 60-69 Yip1 interacting factor homolog B (S. cerevisiae) Mus musculus 51-56 32459080-4 2020 Results: Compared with wild-type mice, Yif1B-knockout mice showed a significant decrease in the forebrain density of 5-HT projection fibres and a hypofunctionality of 5-HT1A autoreceptors expressed on raphe 5-HT neurons. Serotonin 117-121 Yip1 interacting factor homolog B (S. cerevisiae) Mus musculus 39-44 32459080-4 2020 Results: Compared with wild-type mice, Yif1B-knockout mice showed a significant decrease in the forebrain density of 5-HT projection fibres and a hypofunctionality of 5-HT1A autoreceptors expressed on raphe 5-HT neurons. Serotonin 167-171 Yip1 interacting factor homolog B (S. cerevisiae) Mus musculus 39-44 32459080-9 2020 Conclusion: These data support the concept that Yif1B plays a critical role in 5-HT1AR functioning and brain 5-HT homeostasis. Serotonin 79-83 Yip1 interacting factor homolog B (S. cerevisiae) Mus musculus 48-53 31905370-2 2020 ErbB4, a receptor tyrosine kinase, is expressed in 5-HT neurons. Serotonin 51-55 erb-b2 receptor tyrosine kinase 4 Mus musculus 0-5 31905370-4 2020 Here, using transgenic and viral approaches, we show that mice with ErbB4 deficiency in 5-HT neurons exhibit heightened anxiety-like behavior and impaired fear extinction, possibly due to an increased excitability of 5-HT neurons in the dorsal raphe nucleus (DRN). Serotonin 88-92 erb-b2 receptor tyrosine kinase 4 Mus musculus 68-73 31905370-4 2020 Here, using transgenic and viral approaches, we show that mice with ErbB4 deficiency in 5-HT neurons exhibit heightened anxiety-like behavior and impaired fear extinction, possibly due to an increased excitability of 5-HT neurons in the dorsal raphe nucleus (DRN). Serotonin 217-221 erb-b2 receptor tyrosine kinase 4 Mus musculus 68-73 31905370-5 2020 Notably, the chemogenetic inhibition of 5-HT neurons in the DRN of ErbB4 mutant mice rescues anxiety-like behaviors. Serotonin 40-44 erb-b2 receptor tyrosine kinase 4 Mus musculus 67-72 31905370-6 2020 Altogether, our results unravel a previously unknown role of ErbB4 signaling in the regulation of DRN 5-HT neuronal function and anxiety-like behaviors, providing novel insights into the treatment of anxiety disorders. Serotonin 102-106 erb-b2 receptor tyrosine kinase 4 Mus musculus 61-66 32640190-0 2020 RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis. Serotonin 52-61 piezo-type mechanosensitive ion channel component 1 Mus musculus 19-25 32640190-3 2020 Here, we reveal that the cation channel Piezo1 in the gut acts as a sensor of single-stranded RNA (ssRNA) governing 5-HT production. Serotonin 116-120 piezo-type mechanosensitive ion channel component 1 Mus musculus 40-46 32640190-4 2020 Intestinal epithelium-specific deletion of mouse Piezo1 profoundly disturbed gut peristalsis, impeded experimental colitis, and suppressed serum 5-HT levels. Serotonin 145-149 piezo-type mechanosensitive ion channel component 1 Mus musculus 49-55 32311818-10 2020 CONCLUSION: We demonstrate that OCT3, localized on the fetus-facing membrane of syncytiotrophoblast, is an essential component of feto-placental homeostasis of 5-HT. Serotonin 160-164 solute carrier family 22 member 8 Rattus norvegicus 32-36 32311818-11 2020 Together with 5-HT degrading enzyme, monoamine oxidase-A, this offers a protective mechanism against local vasoconstriction effects of 5-HT in the placenta. Serotonin 135-139 monoamine oxidase A Homo sapiens 37-56 31943210-6 2020 An in-vivo microdialysis study in EFhd2 knock out (KO) mice revealed that EFhd2 controls METH- and cocaine-induced changes in extracellular dopamine (DA), serotonin and noradrenaline levels through different mechanisms in the nucleus accumbens (NAc) and prefrontal cortex (PFC). Serotonin 155-164 EF hand domain containing 2 Mus musculus 74-79 32243582-1 2020 KEY POINTS: During maximal effort contractions, intense serotonin release via the raphe-spinal pathway spills over from the somato-dendritic compartment to activate inhibitory 5-HT1A receptors on the axon initial segment of motoneurons to reduce motoneuronal output. Serotonin 56-65 5-hydroxytryptamine receptor 1A Homo sapiens 176-182 22241550-0 2012 Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. Serotonin 83-92 tryptophan hydroxylase 2 Macaca mulatta 12-36 32594910-1 2020 The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 122-151 22282879-3 2012 The presence of additional IDO directs more tryptophan down the kynurenine pathway, leaving less available for synthesis of serotonin and its metabolites. Serotonin 124-133 indoleamine 2,3-dioxygenase 1 Homo sapiens 27-30 32594910-1 2020 The serotonin (5-HT) system is the target of multiple anxiolytics, including Buspirone, which is a partial agonist of the serotonin 1A receptor (5-HT1A). Serotonin 15-19 5-hydroxytryptamine receptor 1A Homo sapiens 122-151 32594910-11 2020 These observations suggest that most glutamatergic neurons can respond to 5-HT through 5-HT1A or 5-HT2A in the insula, and that 5-HT directly affects a limited number of GABAergic neurons. Serotonin 74-78 5-hydroxytryptamine receptor 1A Homo sapiens 87-93 32169543-3 2020 To examine LDAEP"s relationship with the serotonin system, we performed PET using serotonin-1A (5-HT1A) imaging via [11C]CUMI-101 and serotonin transporter (5-HTT) imaging via [11C]DASB on a mixed sample of healthy controls (n = 4: 4 females, 0 males), patients with unipolar (MDD, n = 11: 4 females, 7 males) and bipolar depression (BD, n = 8: 4 females, 4 males). Serotonin 82-91 5-hydroxytryptamine receptor 1A Homo sapiens 96-102 22222679-5 2012 It has been reported that HFS-STN decreases serotonin release in several regions, mostly via inhibition of serotonergic neuron activity. Serotonin 44-53 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 30-33 32244397-3 2020 Chemical stressors influence behavioral outcomes by affecting the monoamine oxidase A (MAOA) enzyme, which is involved in serotonin metabolism and the neuroendocrine response to stress. Serotonin 122-131 monoamine oxidase A Homo sapiens 66-85 21946431-0 2012 Functional significance of glycogen synthase kinase-3 regulation by serotonin. Serotonin 68-77 glycogen synthase kinase 3 beta Mus musculus 27-53 21946431-2 2012 Enhancing brain serotonin has been found to regulate glycogen synthase Kinase-3 (GSK3), but the signaling mechanism and functional significance of this regulation remain to be determined. Serotonin 16-25 glycogen synthase kinase 3 beta Mus musculus 53-79 21946431-2 2012 Enhancing brain serotonin has been found to regulate glycogen synthase Kinase-3 (GSK3), but the signaling mechanism and functional significance of this regulation remain to be determined. Serotonin 16-25 glycogen synthase kinase 3 beta Mus musculus 81-85 32244397-3 2020 Chemical stressors influence behavioral outcomes by affecting the monoamine oxidase A (MAOA) enzyme, which is involved in serotonin metabolism and the neuroendocrine response to stress. Serotonin 122-131 monoamine oxidase A Homo sapiens 87-91 22166418-3 2012 In this neurorescue/neurorestorative paradigm, M30 was orally administered to mice for 14 days (2.5-5 mg/kg/day) following post MPTP or lactacystin lesion and was shown to significantly elevate striatal dopamine, serotonin and noradrenaline levels, reduce their metabolism, and elevate tyrosine-hydroxylase protein levels. Serotonin 213-222 olfactory receptor family 10 subfamily N member 1 Mus musculus 47-50 32125287-5 2020 The brain transitivity and the serotonin reuptake inhibition of Alk-S-Cit were not significantly different as compared to S-Cit. Serotonin 31-40 anaplastic lymphoma kinase Mus musculus 64-67 22762012-7 2012 Interestingly, the 5-HT(1A) receptor agonist buspirone has been shown to suppress GID in these patients, suggesting that serotonin neurons might be involved in the etiology of GID as for LID. Serotonin 121-130 5-hydroxytryptamine receptor 1A Homo sapiens 19-36 22108649-3 2012 Monoamine release is facilitated by nAChR stimulation, and nicotine-evoked serotonin (5-HT) release has been shown to depend on alpha7 nAChR activation. Serotonin 75-84 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 135-140 22792172-8 2012 Intraluminal IGFBP-3 decreased both pressure- and serotonin-induced constrictions by stimulating nitric oxide (NO) release that were blocked by L-NAME or scavenger receptor-B1 neutralizing antibody (SRB1-Ab). Serotonin 50-59 insulin-like growth factor binding protein 3 Mus musculus 13-20 22169038-3 2011 Here we used mice with increased or decreased brain SIRT1 to show that this sirtuin regulates anxiety and exploratory drive by activating transcription of the gene encoding the monoamine oxidase A (MAO-A) to reduce serotonin levels in the brain. Serotonin 215-224 sirtuin 1 Mus musculus 52-57 22396896-3 2011 Activation of IDO shunts TRY metabolism from production of serotonin (substrate of antidepressant effect) and its derivatives: N-acetylserotonin (an agonist to the receptors of brain derived neurotropic factor), and melatonin (regulator of sleep and other circadian rhythms), towards production of KYN and its derivatives (anxiogenic, neurotoxic and pro-oxidant factors). Serotonin 59-68 indoleamine 2,3-dioxygenase 1 Homo sapiens 14-17 21798367-10 2011 Preliminary data showed that several of the serotonin conjugates are able to inhibit glucagon-like peptide-1 secretion and FAAH activity in vitro. Serotonin 44-53 fatty acid amide hydrolase Mus musculus 123-127 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 95-104 interleukin 4 Mus musculus 40-44 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 95-104 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 270-298 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 95-104 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 300-304 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 95-104 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 309-316 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 106-125 interleukin 4 Mus musculus 40-44 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 106-125 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 270-298 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 106-125 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 300-304 21636115-5 2011 RESULTS: We found a drastic decrease in IL-4 production by stimulated basophils on exposure to serotonin (5-hydroxytryptamine [5-HT]) that is taken up by basophils through the specific high-affinity transporters serotonin transporter and the polyspecific, high-capacity organic cation transporter 3 (OCT3; or Slc22a3) but inhibits their function exclusively through the latter. Serotonin 106-125 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 309-316 21873225-4 2011 We assessed the ability of serotonin signaling to alter brain Abeta levels and plaques in a mouse model of AD and in humans. Serotonin 27-36 amyloid beta (A4) precursor protein Mus musculus 62-67 21873225-6 2011 Similarly, direct infusion of serotonin into the hippocampus reduced ISF Abeta levels. Serotonin 30-39 amyloid beta (A4) precursor protein Mus musculus 73-78 21194755-3 2011 In this view, we aimed to analyse the specific effect of the -1019C/G functional polymorphism of the serotonin 1A receptor (5-HT1A-R), involved in both serotonin and dopamine transmission regulation. Serotonin 101-110 5-hydroxytryptamine receptor 1A Homo sapiens 124-130 21660541-5 2011 In Calliphora, PDF-immunoreactive processes of LN(v)s in the lamina closely impinge on branching serotonin-immunoreactive axon terminations in the same region. Serotonin 97-106 Pigment-dispersing factor Drosophila melanogaster 15-18 21660541-9 2011 However, peptidergic neurons with branches converging on the serotonin-immunoreactive neurons in the lamina are of different morphological types and express PDF in blowflies and MIP in Drosophila. Serotonin 61-70 Pigment-dispersing factor Drosophila melanogaster 157-160 21660541-9 2011 However, peptidergic neurons with branches converging on the serotonin-immunoreactive neurons in the lamina are of different morphological types and express PDF in blowflies and MIP in Drosophila. Serotonin 61-70 Myoinhibiting peptide precursor Drosophila melanogaster 178-181 21515689-14 2011 Serotonin (5-HT) also increased GDNF production through FGFR2 (Tsuchioka, M., Takebayashi, M., Hisaoka, K., Maeda, N., and Nakata, Y. Serotonin 0-9 fibroblast growth factor receptor 2 Homo sapiens 56-61 21653851-3 2011 Here we show that serotonin via 5-HT(1B) heteroreceptors substantially reduces synaptic excitation of cholecystokinin-expressing interneurons in area CA1 of the rat hippocampus, in contrast to parvalbumin-expressing basket cells. Serotonin 18-27 carbonic anhydrase 1 Rattus norvegicus 150-153 21653851-5 2011 As a result, serotonin selectively decreases feedback inhibition via 5-HT(1B) receptor activation and subsequently increases the integration time window for spike generation in CA1 pyramidal cells. Serotonin 13-22 carbonic anhydrase 1 Rattus norvegicus 177-180 21426346-3 2011 Our lab has previously shown that treatment with the facilitating neurotransmitter, 5-hydroxytryptamine (5-HT), causes a target of rapamycin complex 1-mediated decrease in phosphorylation of eukaryotic elongation factor 2 (eEF2) within the neurites of sensory neurons involved in LTF. Serotonin 84-103 eukaryotic translation elongation factor 2 Homo sapiens 191-221 21426346-3 2011 Our lab has previously shown that treatment with the facilitating neurotransmitter, 5-hydroxytryptamine (5-HT), causes a target of rapamycin complex 1-mediated decrease in phosphorylation of eukaryotic elongation factor 2 (eEF2) within the neurites of sensory neurons involved in LTF. Serotonin 84-103 eukaryotic translation elongation factor 2 Homo sapiens 223-227 21382916-2 2011 Some neurotransmitters, such as serotonin, can regulate T- and B-cell proliferation via the 5-HT1A receptor and are involved in the pathology of SLE. Serotonin 32-41 5-hydroxytryptamine receptor 1A Homo sapiens 92-107 21609470-9 2011 CONCLUSIONS: We have identified that the level of catecholamines and serotonin is differentially affected in Mecp2(-/y) brain areas in a time-dependent fashion. Serotonin 69-78 methyl CpG binding protein 2 Mus musculus 109-114 21377330-1 2011 PURPOSE: Indoleamine 2,3-dioxygenase (IDO) is a cytokine-inducible enzyme that participates in tryptophan (trp) and serotonin metabolism with an ability to modulate neuroinflammation. Serotonin 116-125 indoleamine 2,3-dioxygenase 1 Homo sapiens 9-36 21377330-1 2011 PURPOSE: Indoleamine 2,3-dioxygenase (IDO) is a cytokine-inducible enzyme that participates in tryptophan (trp) and serotonin metabolism with an ability to modulate neuroinflammation. Serotonin 116-125 indoleamine 2,3-dioxygenase 1 Homo sapiens 38-41 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Serotonin 98-107 monoamine oxidase A Homo sapiens 12-31 20810002-1 2011 BACKGROUND: Monoamine oxidase A (MAOA) is an important enzyme that metabolizes monoamines such as serotonin, norepinephrine and dopamine in the brain. Serotonin 98-107 monoamine oxidase A Homo sapiens 33-37 21247719-5 2011 A good linear relationship with coefficients >=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK). Serotonin 121-140 proenkephalin Rattus norvegicus 202-212 21247719-5 2011 A good linear relationship with coefficients >=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK). Serotonin 121-140 proenkephalin Rattus norvegicus 216-219 21247719-5 2011 A good linear relationship with coefficients >=0.99 was achieved over the concentration ranges of 10-1000ngmL(-1) for 5-hydroxytryptamine (5-HT) and norepinephrine (NE); 2-250ngmL(-1) for methionine-enkephalin (M-ENK) and leucine-enkephalin (L-ENK). Serotonin 121-140 proenkephalin Rattus norvegicus 247-250 21118676-0 2011 Hippocampal serotonin depletion facilitates place learning concurrent with an increase in CA1 high frequency theta activity expression in the rat. Serotonin 12-21 carbonic anhydrase 1 Rattus norvegicus 90-93 21161299-9 2011 IFN-induced up-regulation of IDO triggers depression by shifting TRY metabolism from formation of serotonin to production of neuroactive kynurenines. Serotonin 98-107 indoleamine 2,3-dioxygenase 1 Homo sapiens 29-32 21181116-2 2011 The present study aims to verify the effects of single and repeated injections of MDMA on dynorphin and nociceptin systems gene regulation in the brainstem, an area rich in neurons containing serotonin. Serotonin 192-201 prepronociceptin Rattus norvegicus 104-114 21187319-1 2011 Recent evidence indicates that leptin regulates appetite and energy expenditure, at least in part by inhibiting serotonin synthesis and release from brainstem neurons. Serotonin 112-121 leptin Mus musculus 31-37 21187319-2 2011 To demonstrate that this pathway works postnatally, we used a conditional, brainstem-specific mouse CreER(T2) driver to show that leptin signals in brainstem neurons after birth to decrease appetite by inhibiting serotonin synthesis. Serotonin 213-222 leptin Mus musculus 130-136 21187319-3 2011 Cell-specific gene deletion experiments and intracerebroventricular leptin infusions reveal that serotonin signals in arcuate nuclei of the hypothalamus through the Htr1a receptor to favor food intake and that this serotonin function requires the expression of Creb, which regulates the expression of several genes affecting appetite. Serotonin 97-106 leptin Mus musculus 68-74 21187319-5 2011 Collectively, these results establish that leptin inhibition of serotonin is necessary to inhibit appetite postnatally and provide a proof of principle that selective inhibition of this pathway may be a viable option to treat appetite disorders. Serotonin 64-73 leptin Mus musculus 43-49 21123435-0 2011 Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model. Serotonin 51-60 corticotropin releasing hormone Homo sapiens 21-24 20858707-4 2010 hPMAT is highly selective toward serotonin (5-HT) and dopamine, with the rank order of transport efficiency (V(max)/K(m)) being: dopamine, 5-HT >> histamine, norepinephrine, epinephrine. Serotonin 33-42 solute carrier family 29 member 4 Homo sapiens 0-5 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase A Homo sapiens 157-176 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase A Homo sapiens 178-183 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Serotonin 137-146 monoamine oxidase A Homo sapiens 20-25 19339602-2 2009 Here, we show that the Hh receptor Patched-related factor DAF-6 and intraflagellar transport modulate serotonin production in Caenorhabditis elegans animals, by remodeling the architecture of dendritic cilia of a pair of ADF serotonergic chemosensory neurons. Serotonin 102-111 SSD domain-containing protein Caenorhabditis elegans 58-63 19339602-3 2009 Wild-type animals under aversive environment drastically reduce DAF-6 expression in glia-like cells surrounding the cilia of chemosensory neurons, resulting in cilium structural remodeling and upregulation of the serotonin-biosynthesis enzyme tryptophan hydroxylase tph-1 in the ADF neurons. Serotonin 213-222 SSD domain-containing protein Caenorhabditis elegans 64-69 19308295-0 2009 Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. Serotonin 13-22 nitric oxide synthase 3, endothelial cell Mus musculus 107-140 19237285-0 2009 Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation. Serotonin 22-31 5-hydroxytryptamine receptor 1A Homo sapiens 32-38 19374846-0 2009 Intracolonical administration of protease-activated receptor-2 agonists produced visceral hyperalgesia by up-regulating serotonin in the colon of rats. Serotonin 120-129 F2R like trypsin receptor 1 Rattus norvegicus 33-62 18830239-2 2009 This encourages interest in association of NK(1) receptor blockade with inhibition of serotonin (5-HT) reuptake. Serotonin 86-95 tachykinin receptor 1 Rattus norvegicus 43-57 19095043-0 2009 Extra-nuclear estrogen receptor GPR30 regulates serotonin function in rat hypothalamus. Serotonin 48-57 G protein-coupled estrogen receptor 1 Rattus norvegicus 32-37 18810510-7 2009 Findings are discussed considering the metabolic association among DAT, 5-HTT and MAOA with special emphasis on the linked action of 5-HTT/MAOA in regulating serotonin metabolism of SIDS and SIUD infants. Serotonin 158-167 monoamine oxidase A Homo sapiens 139-143 19029097-4 2009 We aimed to investigate the alteration in the density of 5-HT(1A) receptors, that may also alter the effect of serotonin in the pACC in alcoholics. Serotonin 111-120 5-hydroxytryptamine receptor 1A Homo sapiens 57-64 18781376-2 2009 Here, we investigated the mechanism of hERG K(+) channel current (I(hERG)) blockade expressed in HEK-293 cells by sibutramine HCl, a serotonin-norepinephrine reuptake inhibitor. Serotonin 133-142 potassium voltage-gated channel subfamily H member 2 Homo sapiens 39-73 18606193-4 2008 Pharmacological challenge studies using 5-HT(1A) agonism and antagonism to manipulate the serotonin system support involvement of the 5-HT(1A) receptor in human cognition, mainly in verbal memory functioning. Serotonin 90-99 5-hydroxytryptamine receptor 1A Homo sapiens 134-151 19033200-0 2008 Organic cation transporter 3: Keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. Serotonin 65-74 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 0-28 18565198-8 2008 The present study demonstrates that vascular smooth muscle (VSM) contractions to phenylephrine and serotonin, but not to U46619, were blunted in Gla(-/0) mice. Serotonin 99-108 galactosidase, alpha Mus musculus 145-148 18761712-7 2008 The knowledge of the phenotype of the prefrontal cortex (PFC) cells expressing 5-HT(1A) will help understanding serotonin actions in PFC. Serotonin 112-121 5-hydroxytryptamine receptor 1A Homo sapiens 79-86 20799027-0 2010 [(3)H]-F13640, a novel, selective and high-efficacy serotonin 5-HT(1A) receptor agonist radioligand. Serotonin 52-61 5-hydroxytryptamine receptor 1A Homo sapiens 62-79 20073575-3 2010 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Serotonin 32-41 monoamine oxidase A Homo sapiens 59-78 18602929-4 2008 When not bound to syntaxin 1A, SERT shows both substrate-independent Na(+) fluxes and substrate-dependent Na(+) fluxes of variable stoichiometry; these fluxes are eliminated in the presence of syntaxin 1A as Na(+) flux becomes strictly coupled to 5HT uptake. Serotonin 247-250 syntaxin 1A Homo sapiens 193-204 32256314-7 2020 Outside of those excitatory neurons, over 90% of Oxtr-expressing neurons co-express glutamic acid decarboxylase-1 (Gad-1) with progressively decreasing numbers of co-expressing cholecystokinin, somatostatin, parvalbumin, neuronal nitric oxide synthase, the serotonin 3a receptor, the vesicular glutamate transporter 3, calbindin 2 (calretinin), and vasoactive intestinal polypeptide neurons. Serotonin 257-266 oxytocin receptor Mus musculus 49-53 18602929-6 2008 In the present experiments, we show that inhibitors of calcium/calmodulin-dependent kinase II (CaM kinase II) modulate the stoichiometry of 5HT flux and that this effect requires syntaxin 1A. Serotonin 140-143 syntaxin 1A Homo sapiens 179-190 18653660-0 2008 Serotonin facilitates long-term depression induction in prefrontal cortex via p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization. Serotonin 0-9 RAB5A, member RAS oncogene family Homo sapiens 87-91 18653660-8 2008 The serotonin-facilitated LTD induction was prevented by blocking the activation of the small GTPase Rab5, as well as by blocking the clathrin-dependent internalization of AMPA receptors with postsynaptic injection of a dynamin inhibitory peptide, while it was unaffected by manipulating the cytoskeleton. Serotonin 4-13 RAB5A, member RAS oncogene family Homo sapiens 101-105 20073575-3 2010 We have recently shown that the serotonin-degrading enzyme monoamine oxidase A (MAO-A) generates large amount of hydrogen peroxide (H2O2) responsible for cell apoptosis. Serotonin 32-41 monoamine oxidase A Homo sapiens 80-85 20073575-5 2010 In the present study, we investigated whether MAO-A is expressed in MSCs and we defined its role in serotonin-dependent MSCs apoptosis. Serotonin 100-109 monoamine oxidase A Homo sapiens 46-51 20073575-7 2010 As shown by enzyme assays using [14C]serotonin or [14C]beta-phenylethylamine as selective MAO-A or MAO-B substrates, MAO-A is largely predominant in MSCs. Serotonin 37-46 monoamine oxidase A Homo sapiens 117-122 31628858-0 2020 Dual roles for the TSPYL family in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors in MDD patients. Serotonin 45-54 TSPY like 1 Homo sapiens 19-24 20689986-5 2010 The release of EDRF from the endothelium can be mediated by both pertussis toxin-sensitive G(i) (alpha(2)-adrenergic activation, serotonin, thrombin) and insensitive G(q) (adenosine diphosphate, bradykinin) coupling proteins. Serotonin 129-138 alpha hemoglobin stabilizing protein Homo sapiens 15-19 20729489-8 2010 Intriguing aspects of this regulation include the intracellular interplay of SERT with the small G protein Rab4 and the concerted 5HT-mediated phosphorylation of vimentin. Serotonin 130-133 vimentin Homo sapiens 162-170 18047755-1 2008 5-HT1A receptors are key components of the serotonin system, acting both pre- and post- synaptically in different brain areas. Serotonin 43-52 5-hydroxytryptamine receptor 1A Homo sapiens 0-6 18628395-10 2008 In the brains of ns3 mutants, excess serotonin and insulin accumulate, while peripheral insulin pathway activation is low. Serotonin 37-46 Nucleostemin 3 Drosophila melanogaster 17-20 31628858-0 2020 Dual roles for the TSPYL family in mediating serotonin transport and the metabolism of selective serotonin reuptake inhibitors in MDD patients. Serotonin 97-106 TSPY like 1 Homo sapiens 19-24 31759303-4 2020 The mostly prescribed antidepressants for sleep are trazodone (a weak, but specific inhibitor of the synaptosomal uptake of serotonin, that also binds to alpha-1 and alpha-2 adrenoreceptor sites) and mirtazapine (a postsynaptic drug which enhances noradrenergic and 5-HT1A-mediated serotonergic neurotransmission via antagonism of central alpha-2-auto- and hetero-adrenoreceptors). Serotonin 124-133 adrenoceptor alpha 1D Homo sapiens 154-161 17957216-4 2008 This effect seems to be mediated by enhanced intraseptal serotonergic transmission via serotonin (5-HT)1A receptors since NK1R blockade reversed the swim stress-induced decrease to an increase in extracellular 5-HT efflux, and furthermore the behavioral effects of L-822429 were blocked by intraseptal 5-HT1A receptor antagonism. Serotonin 87-96 tachykinin receptor 1 Rattus norvegicus 122-126 18442977-9 2008 Taken together, our study suggests that serotonin, via 5-HT(1A) and 5-HT(2A/C) receptor activation, regulates NMDAR functions in PFC neurons in a counteractive manner. Serotonin 40-49 5-hydroxytryptamine receptor 1A Homo sapiens 55-62 20660258-9 2010 We conclude that synapsins play different roles in the control of release of dopamine and serotonin, with release of dopamine being negatively regulated by synapsins, specifically synapsin III, while serotonin release appears to be relatively independent of synapsins. Serotonin 90-99 synapsin III Mus musculus 180-192 31806625-7 2020 Growth hormone (GH) was found to induce serotonin production in beta-cells through activation of STAT5 during the perinatal period. Serotonin 40-49 growth hormone Mus musculus 0-14 20633138-0 2010 Neuromedin U is necessary for normal gastrointestinal motility and is regulated by serotonin. Serotonin 83-92 neuromedin U Mus musculus 0-12 18501009-1 2008 BACKGROUND: Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin. Serotonin 134-143 monoamine oxidase A Homo sapiens 12-31 18501009-1 2008 BACKGROUND: Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in degrading several different biological amines, including serotonin. Serotonin 134-143 monoamine oxidase A Homo sapiens 33-37 20592420-4 2010 The dyskinesias were markedly attenuated by systemic administration of a serotonin [5-hydroxytryptamine (5-HT)] receptor (5-HT(1A)) agonist, which dampens transmitter release from serotonergic neurons, indicating that the dyskinesias were caused by the serotonergic hyperinnervation. Serotonin 73-82 5-hydroxytryptamine receptor 1A Homo sapiens 122-129 31806625-7 2020 Growth hormone (GH) was found to induce serotonin production in beta-cells through activation of STAT5 during the perinatal period. Serotonin 40-49 growth hormone Mus musculus 16-18 20592420-4 2010 The dyskinesias were markedly attenuated by systemic administration of a serotonin [5-hydroxytryptamine (5-HT)] receptor (5-HT(1A)) agonist, which dampens transmitter release from serotonergic neurons, indicating that the dyskinesias were caused by the serotonergic hyperinnervation. Serotonin 84-103 5-hydroxytryptamine receptor 1A Homo sapiens 122-129 20592420-4 2010 The dyskinesias were markedly attenuated by systemic administration of a serotonin [5-hydroxytryptamine (5-HT)] receptor (5-HT(1A)) agonist, which dampens transmitter release from serotonergic neurons, indicating that the dyskinesias were caused by the serotonergic hyperinnervation. Serotonin 105-109 5-hydroxytryptamine receptor 1A Homo sapiens 122-129 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Serotonin 128-137 monoamine oxidase A Homo sapiens 24-43 31806625-7 2020 Growth hormone (GH) was found to induce serotonin production in beta-cells through activation of STAT5 during the perinatal period. Serotonin 40-49 signal transducer and activator of transcription 5A Mus musculus 97-102 18463263-1 2008 The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Serotonin 128-137 monoamine oxidase A Homo sapiens 45-50 31806625-8 2020 Thus, our results indicate that GH-GH receptor-STAT5-serotonin-HTR2B signaling plays a critical role in determining the beta-cell mass by regulating perinatal beta-cell proliferation, and defects in this pathway affect metabolic phenotypes in adults. Serotonin 53-62 signal transducer and activator of transcription 5A Mus musculus 47-52 31776207-4 2020 LY344864, a 5-hydroxytryptamine 1F (5-HT1F) receptor agonist, is a potent inducer of MB in multiple organ systems. Serotonin 12-34 5-hydroxytryptamine (serotonin) receptor 1F Mus musculus 36-42 17945348-3 2008 Because tryptophan is a precursor of the neurotransmitter 5-hydroxytryptamine (serotonin), tryptophan depletion by IDO can cause mood disturbances in patients with chronic immune activation. Serotonin 58-77 indoleamine 2,3-dioxygenase 1 Homo sapiens 115-118 17945348-3 2008 Because tryptophan is a precursor of the neurotransmitter 5-hydroxytryptamine (serotonin), tryptophan depletion by IDO can cause mood disturbances in patients with chronic immune activation. Serotonin 79-88 indoleamine 2,3-dioxygenase 1 Homo sapiens 115-118 20481570-0 2010 Discovery of bishomo(hetero)arylpiperazines as novel multifunctional ligands targeting dopamine D(3) and serotonin 5-HT(1A) and 5-HT(2A) receptors. Serotonin 105-114 5-hydroxytryptamine receptor 1A Homo sapiens 115-122 31912839-8 2020 In wild-type N2 worms, luteolin treatment not only elevated the expression of tph-1, but also enhanced the mRNA levels of mod-1 and ser-6, which are two serotonin-related receptors and play specific roles in serotonin-mediated fat reduction. Serotonin 153-162 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 132-137 20520823-4 2010 Quantitative morphological examination demonstrated that our newly generated tryptophan hydroxylase (TRH)-Gal4 driver line was highly selective for 5HT-containing neurons. Serotonin 148-151 Tryptophan hydroxylase Drosophila melanogaster 77-99 17574270-2 2008 Brainstem 5-HT1A somatodendritic autoreceptors regulate serotonin neuron firing but studies of autoreceptor binding in the dorsal raphe nucleus (DRN) in depressed suicides report conflicting results. Serotonin 56-65 5-hydroxytryptamine receptor 1A Homo sapiens 10-16 31912839-8 2020 In wild-type N2 worms, luteolin treatment not only elevated the expression of tph-1, but also enhanced the mRNA levels of mod-1 and ser-6, which are two serotonin-related receptors and play specific roles in serotonin-mediated fat reduction. Serotonin 208-217 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 132-137 20520823-4 2010 Quantitative morphological examination demonstrated that our newly generated tryptophan hydroxylase (TRH)-Gal4 driver line was highly selective for 5HT-containing neurons. Serotonin 148-151 Tryptophan hydroxylase Drosophila melanogaster 101-104 31998441-10 2020 Additionally, serotonin promoted hepatocyte apoptosis and autophagy based on B-cell lymphoma-2 (Bcl-2), Bcl-2-asociated X protein (Bax), and Beclin-1 levels and TUNEL staining. Serotonin 14-23 beclin 1, autophagy related Mus musculus 141-149 18313943-4 2008 In the present PET study, we used an antagonist of 5-HT(1A) receptors, the [(18)F]MPPF (1) to explore 5-HT(1A) receptor density in the whole brain of AD patients at a mild stage of dementia and amnestic mild cognitive impairment (aMCI) patients compared to a control population; (2) to explore more precisely the 5-HT(1A) receptor density in the limbic brain regions of AD patients and aMCI patients compared to controls. Serotonin 51-55 5-hydroxytryptamine receptor 1A Homo sapiens 102-119 31771567-0 2019 Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis. Serotonin 100-109 cathepsin L Mus musculus 11-22 20456957-0 2010 Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors. Serotonin 0-9 ret proto-oncogene Homo sapiens 60-84 20456957-4 2010 We describe here serotonin derivatives as a new class of multiple targeted RTK inhibitors. Serotonin 17-26 ret proto-oncogene Homo sapiens 75-78 18094327-7 2008 3H-serotonin and ATP secretion were greatly reduced in SG-/- platelets. Serotonin 3-12 serglycin Mus musculus 55-57 31771567-4 2019 We now provide evidence from Caenorhabditis elegans and mouse models to suggest a conserved regulatory circuit in which peripheral cathepsin L inhibition lowers fat accumulation through promoting central serotonin synthesis. Serotonin 204-213 cathepsin L Mus musculus 131-142 20332520-0 2010 Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity. Serotonin 50-59 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 16-21 31771567-10 2019 Cathepsin L knockout promoted fat loss and central serotonin synthesis. Serotonin 51-60 cathepsin L Mus musculus 0-11 20332520-2 2010 We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating histamine- and serotonin-induced visceral hypersensitivity. Serotonin 105-114 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 21-26 31612178-0 2019 Hierarchical Au nanoclusters electrodeposited on amine-terminated ITO glass as a SERS-active substrate for the reliable and sensitive detection of serotonin in a Tris-HCl buffer solution. Serotonin 147-156 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 81-85 20332520-7 2010 Serotonin or histamine treatments enhanced TRPV4 expression at the plasma membrane by a MAPKK mechanism. Serotonin 0-9 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 43-48 20332520-8 2010 Hypersensitivity induced by serotonin or histamine were both significantly inhibited by TRPV4 SiRNA intrathecal injection. Serotonin 28-37 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 88-93 20332520-10 2010 CONCLUSIONS: Serotonin and histamine sensitise TRPV4 response to 4alphaPDD both in vivo (increased visceral hypersensitivity) and in vitro, in sensory neurons, by a PKC, PLA(2), PLCbeta and MAPKK-dependent mechanism. Serotonin 13-22 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 47-52 20332520-11 2010 Serotonin and histamine caused a MAPKK-dependent increase in TRPV4 expression in colonic sensory neurons plasma membranes. Serotonin 0-9 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 61-66 20332520-12 2010 Further, histamine- or serotonin-mediated visceral hypersensitivity depend on TRPV4 expression in sensory neurons. Serotonin 23-32 transient receptor potential cation channel, subfamily V, member 4 Mus musculus 78-83 20099302-11 2010 Serotonin could override rapamycin by an mTOR-independent pathway and activate common downstream signals such as p70S6K and 4E-BP1. Serotonin 0-9 ribosomal protein S6 kinase B1 Homo sapiens 113-130 17669489-0 2008 Serotonin-induced activation of TRPV4-like current in rat intrapulmonary arterial smooth muscle cells. Serotonin 0-9 transient receptor potential cation channel, subfamily V, member 4 Rattus norvegicus 32-37 18234316-6 2008 The amounts of histamine/serotonin stored were reflected by the expression levels of histidine decarboxylase and tryptophan hydroxylase 1, respectively. Serotonin 25-34 tryptophan hydroxylase 1 Homo sapiens 113-137 18339980-1 2008 Serotonin (5-HT) regulates aggressive behavior via binding to its receptors, such as 5-HT1A and 1B, in humans and rodents. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 85-98 18211820-5 2008 Consistent results of the upstream regulatory element search and the co-localization search of these genes indicated that the regulation may be executed by Pax5, Pax7 and Gata3, known to be involved in the survival, proliferation, and migration of serotonergic neurons in the developing brain, and these factors are supposed to keep functioning to regulate downstream genes related to serotonin system in the adult brain. Serotonin 385-394 paired box 5 Mus musculus 156-160 31612178-1 2019 Although serotonin (5-HT) is one of the most important neurotransmitters that are responsible for critical roles in the central nervous system, only few studies have been reported on the reliable and sensitive detection of 5-HT by the SERS technique owing to the lower Raman cross-section and lack of a common extraction method of 5-HT. Serotonin 9-18 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 235-239 18211820-5 2008 Consistent results of the upstream regulatory element search and the co-localization search of these genes indicated that the regulation may be executed by Pax5, Pax7 and Gata3, known to be involved in the survival, proliferation, and migration of serotonergic neurons in the developing brain, and these factors are supposed to keep functioning to regulate downstream genes related to serotonin system in the adult brain. Serotonin 385-394 GATA binding protein 3 Mus musculus 171-176 31612178-1 2019 Although serotonin (5-HT) is one of the most important neurotransmitters that are responsible for critical roles in the central nervous system, only few studies have been reported on the reliable and sensitive detection of 5-HT by the SERS technique owing to the lower Raman cross-section and lack of a common extraction method of 5-HT. Serotonin 223-227 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 235-239 31612178-1 2019 Although serotonin (5-HT) is one of the most important neurotransmitters that are responsible for critical roles in the central nervous system, only few studies have been reported on the reliable and sensitive detection of 5-HT by the SERS technique owing to the lower Raman cross-section and lack of a common extraction method of 5-HT. Serotonin 223-227 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 235-239 18294618-2 2008 The X-linked Mono-Amine Oxidase A (MAO A) gene, coding for an enzyme especially involved in the serotonin (5-HT) catabolism, presents a well-characterized functional polymorphism consisting in a variable number of tandem repeats (VNTR) in the promoter region with high activity and low activity variants. Serotonin 96-105 monoamine oxidase A Homo sapiens 35-40 31612178-2 2019 In this study, a SERS-active substrate was fabricated by electrodepositing hierarchical Au nanostructures on amine-terminated ITO (indium tin oxide) glass to achieve an enhanced Raman signal of 5-HT. Serotonin 194-198 seryl-tRNA synthetase 2, mitochondrial Homo sapiens 17-21 29683396-3 2019 However, a clear biological framework linking dysfunctions in Trp metabolism via 5-HT and Kyn, cortisol, and the activities of tryptophan and indoleamino 2,3-dioxygenase (TDO, IDO) enzymes has not been yet clarified in MDD with or without suicidal behaviours.Methods: We analysed peripheral markers of Trp via 5-HT and Kyn pathways, Kyn/Trp ratio as a measure of TDO/IDO activities, cortisol, and psychopathology in 73 non-suicidal and 56 suicidal MDD patients, and in 40 healthy controls.Results: Plasma Trp levels were lower and the ratio Kyn/Trp higher in suicidal MDD than in non-suicidal MDD patients and controls. Serotonin 310-314 indoleamine 2,3-dioxygenase 1 Homo sapiens 176-179 18366702-7 2008 RESULTS: Our analysis found that significant downregulation of MAO-A, the enzyme that metabolizes serotonin, occurred in multiple tissues from humans, rodents, and fish. Serotonin 98-107 monoamine oxidase A Homo sapiens 63-68 20084070-1 2010 OBJECTIVE: Mice deficient of the serotonin transporter (5-HTT ko) mice have a reduced brain serotonin content and develop late-onset obesity. Serotonin 33-42 huntingtin Mus musculus 58-61 20084070-10 2010 CONCLUSIONS: We propose that low brain serotonin level due to the 5-HTT ko genotype leads to reduced physical activity and low BDNF, which together with the lack of fasting-induced hypothalamic BDNF and LR production results in late-onset obesity. Serotonin 39-48 huntingtin Mus musculus 68-71 20084070-10 2010 CONCLUSIONS: We propose that low brain serotonin level due to the 5-HTT ko genotype leads to reduced physical activity and low BDNF, which together with the lack of fasting-induced hypothalamic BDNF and LR production results in late-onset obesity. Serotonin 39-48 brain derived neurotrophic factor Mus musculus 127-131 20084070-10 2010 CONCLUSIONS: We propose that low brain serotonin level due to the 5-HTT ko genotype leads to reduced physical activity and low BDNF, which together with the lack of fasting-induced hypothalamic BDNF and LR production results in late-onset obesity. Serotonin 39-48 leptin receptor Mus musculus 203-205 31421827-11 2019 And we also provided evidence that SIRT1 inhibition might exert therapeutic effects on PTSD by maintaining serotonin homeostasis through transcriptional inhibition of MAO-A, and thereby remodeled synaptic plasticity in the vCA1 region. Serotonin 107-116 sirtuin 1 Mus musculus 35-40 18096160-3 2008 Antidepressants selectively blocking serotonin reuptake can increase BDNF levels, and also may increase neurogenesis. Serotonin 37-46 brain derived neurotrophic factor Mus musculus 69-73 31251077-2 2019 Serotonin, or 5-hydroxytryptamine (5-HT), induces apnea via acting on 5-HT receptor 3 (5-HT3R) in PCFs, and among the 5-HT3R subunits, 5-HT3B is responsible for shortening the decay time of 5-HT3R-mediated currents. Serotonin 0-9 5-hydroxytryptamine receptor 3B Rattus norvegicus 135-141 20043001-2 2010 We tested the hypothesis that variations in serotonergic genes (TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. Serotonin 108-117 tryptophan hydroxylase 1 Homo sapiens 70-74 20043001-2 2010 We tested the hypothesis that variations in serotonergic genes (TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. Serotonin 108-117 5-hydroxytryptamine receptor 1A Homo sapiens 84-89 31251077-2 2019 Serotonin, or 5-hydroxytryptamine (5-HT), induces apnea via acting on 5-HT receptor 3 (5-HT3R) in PCFs, and among the 5-HT3R subunits, 5-HT3B is responsible for shortening the decay time of 5-HT3R-mediated currents. Serotonin 14-33 5-hydroxytryptamine receptor 3B Rattus norvegicus 135-141 18258310-5 2008 We propose that the MAOA-L, by causing an ontogenic excess of 5-hydroxytryptamine, labilizes critical neural circuitry for social evaluation and emotion regulation (the "socioaffective scaffold"), thereby amplifying the effects of adverse early-life experience and creating deleterious sociocognitive biases. Serotonin 62-81 monoamine oxidase A Homo sapiens 20-24 31571826-1 2019 Introduction : Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, has two major human metabolites, desmethyl-cariprazine (DCAR) and didesmethyl-cariprazine (DDCAR). Serotonin 88-97 5-hydroxytryptamine receptor 1A Homo sapiens 98-113 20641390-16 2004 Although 5-HT1A receptor agonist ligands can elicit pharmacologic effects, there are some distinct potential applications of radiolabeled 5-HT1A receptor agonist ligands because they behave like serotonin, which binds preferentially to the HA sites (1, 9). Serotonin 195-204 5-hydroxytryptamine receptor 1A Homo sapiens 138-153 17973628-1 2008 TPH (tryptophan hydroxylase) catalyses the rate-limiting step in the synthesis of serotonin, and exists in two isoforms: TPH1, mainly found in peripheral tissues and the pineal body, and TPH2, a neuronal form. Serotonin 82-91 tryptophan hydroxylase 1 Homo sapiens 121-125 20377624-7 2010 Second, a behavioral phase-resetting stimulus (wheel-running at midday that induces IGL serotonin release) acutely stimulated SCN NPY release. Serotonin 88-97 neuropeptide Y Homo sapiens 130-133 31492908-0 2019 Serotonin is elevated in risk-genotype carriers of TCF7L2 - rs7903146. Serotonin 0-9 transcription factor 7 like 2 Homo sapiens 51-57 19909795-2 2010 This study explored whether hormone regulation/dysregulation of these systems could be related to gonadal steroid effects on catechol-O-methyltransferase and monoamine oxidase which are principal enzymatic controllers of forebrain dopamine, serotonin and norepinephrine levels. Serotonin 241-250 catechol-O-methyltransferase Rattus norvegicus 125-153 17884271-5 2008 The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression. Serotonin 99-108 monoamine oxidase A Homo sapiens 47-52 31492908-5 2019 Given the role of peripheral serotonin in metabolic homeostasis and type 2 diabetes, this finding provides a first hint that the well-known impact of the TCF7L2 polymorphism on type 2 diabetes risk may involve a serotonin-dependent pathway. Serotonin 29-38 transcription factor 7 like 2 Homo sapiens 154-160 31492908-5 2019 Given the role of peripheral serotonin in metabolic homeostasis and type 2 diabetes, this finding provides a first hint that the well-known impact of the TCF7L2 polymorphism on type 2 diabetes risk may involve a serotonin-dependent pathway. Serotonin 212-221 transcription factor 7 like 2 Homo sapiens 154-160 31371490-5 2019 By modeling the kinetics of intracellular cAMP level changes in relation to the 5-HT7R:5-HT1AR stoichiometry, we were able to decipher the complex signaling characteristics of endogenous serotonin receptors in cultured hippocampal neurons. Serotonin 187-196 5-hydroxytryptamine receptor 1A Homo sapiens 87-94 17890358-0 2007 Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex. Serotonin 86-95 tachykinin 1 Mus musculus 0-11 17890358-0 2007 Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex. Serotonin 86-95 tachykinin 1 Mus musculus 12-24 17890358-2 2007 This therapeutic activity could be mediated via stimulation of serotonin (5-HT) neurons located in the dorsal raphe nucleus (DRN), which receive important SP-NK1 receptor immunoreactive innervations. Serotonin 63-72 tachykinin 1 Mus musculus 158-161 19913081-2 2010 AIM OF THE STUDY: The aim of the present study is to clarify the intrinsic activity of YKS on serotonin (5-HT)1A and 5-HT2A receptors and also to determine the constituent herbs which are responsible for the effect of YKS. Serotonin 94-103 5-hydroxytryptamine receptor 1A Homo sapiens 105-118 19854260-4 2010 The examined neurotransmitters, with the exception of serotonin, were able to potently and transiently increase NT-3 mRNA and NT-3 protein content; their maximal effects were dose- and time-dependent. Serotonin 54-63 neurotrophin 3 Rattus norvegicus 112-116 19854260-4 2010 The examined neurotransmitters, with the exception of serotonin, were able to potently and transiently increase NT-3 mRNA and NT-3 protein content; their maximal effects were dose- and time-dependent. Serotonin 54-63 neurotrophin 3 Rattus norvegicus 126-130 17721552-0 2007 Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Serotonin 19-28 monoamine oxidase A Homo sapiens 53-72 30864194-2 2019 As a potassium channel distributed in hypoglossal motoneurons, TWIK-related acid-sensitive K+ channel-1 (TASK-1) could be inhibited by 5-HT. Serotonin 135-139 potassium two pore domain channel subfamily K member 3 Homo sapiens 63-103 17721552-0 2007 Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Serotonin 19-28 monoamine oxidase A Homo sapiens 74-79 17721552-10 2007 This inhibition of MAO A would be expected to lead to perturbations of 5-hydroxytryptamine metabolism and hence account for ST occurring when administered to patients on SSRI treatment. Serotonin 71-90 monoamine oxidase A Homo sapiens 19-24 21437070-8 2009 Further, expression of mRNA of ACO, medium-chain acyl-CoA dehydrogenase, FAT, and UCP-2 were significantly elevated in serotonin (400 nM)-treated Caco-2 cells compared with cells incubated without serotonin by 28.7%, 30.1%, and 39.2%, respectively. Serotonin 119-128 CD36 molecule Homo sapiens 73-76 19544046-8 2009 In contrast, 5-hydroxytryptamine-induced PE was biphasically regulated by nociceptin and was not antagonized by CGRP8-37. Serotonin 13-32 prepronociceptin Rattus norvegicus 74-84 30807103-3 2019 Early investigation noted that the initial increases in extracellular serotonin engaged strong feedback inhibition of serotonin neurons via 5-HT1A autoreceptors, resulting in a profound reduction in their firing rate. Serotonin 70-79 5-hydroxytryptamine receptor 1A Homo sapiens 140-146 17376153-1 2007 In Drosophila, one enzyme (Drosophila tryptophan-phenylalanine hydroxylase, DTPHu) hydroxylates both tryptophan to yield 5-hydroxytryptophan, the first step in serotonin synthesis, and phenylalanine, to generate tyrosine. Serotonin 160-169 Tryptophan hydroxylase Drosophila melanogaster 76-81 30807103-3 2019 Early investigation noted that the initial increases in extracellular serotonin engaged strong feedback inhibition of serotonin neurons via 5-HT1A autoreceptors, resulting in a profound reduction in their firing rate. Serotonin 118-127 5-hydroxytryptamine receptor 1A Homo sapiens 140-146 30807103-8 2019 That is, baseline serotonin firing rate returns to normal not because of 5-HT1A desensitization but rather despite ongoing feedback inhibition. Serotonin 18-27 5-hydroxytryptamine receptor 1A Homo sapiens 73-79 20157577-5 2009 Recent mouse genetic, electrophysiological and neuroanatomical studies provide evidence that leptin inhibits appetite and bone mass accrual through a two-step pathway: it decreases synthesis and the release by brainstem neurons of serotonin that in turn targets hypothalamic neurons to regulate appetite and bone mass accrual. Serotonin 231-240 leptin Mus musculus 93-99 31027996-4 2019 Compared with IgE-FcepsilonRI stimulation, Mrgprb2 activation of mast cells was distinct in both released substances (histamine, serotonin, and tryptase) and the pattern of activated itch-sensory neurons. Serotonin 129-138 MAS-related GPR, member B2 Mus musculus 43-50 19661285-1 2009 Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions. Serotonin 134-143 monoamine oxidase A Homo sapiens 0-19 19661285-1 2009 Monoamine oxidase A (MAO A), encoded by the X chromosome, catalyzes the oxidative deamination of monoamine neurotransmitters, such as serotonin, and plays a critically important role in brain development and functions. Serotonin 134-143 monoamine oxidase A Homo sapiens 21-26 19837372-3 2009 We determined that the SARM-ASK1-MKK3 module has dual tissue-specific roles in the C. elegans response to pathogens--in the cell-autonomous regulation of innate immunity and the neuroendocrine regulation of serotonin-dependent aversive behavior. Serotonin 207-216 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 28-32 17457312-5 2007 Proinflammatory cytokines such as interleukin-2, interferon-gamma, or tumor necrosis factor-alpha activate the tryptophan- and serotonin-degrading enzyme indoleamine 2,3-dioxygenase (IDO). Serotonin 127-136 indoleamine 2,3-dioxygenase 1 Homo sapiens 183-186 17457312-7 2007 An enhanced consumption of serotonin and its precursor tryptophan through IDO activation could well explain the reduced availability of serotonergic neurotransmission in MD. Serotonin 27-36 indoleamine 2,3-dioxygenase 1 Homo sapiens 74-77 17928982-5 2007 Immune activation with increased production of proinflammatory cytokines activate the tryptophan- and serotonin-degradating enzyme indolamine-2,3-dioxygenase (IDO). Serotonin 102-111 indoleamine 2,3-dioxygenase 1 Homo sapiens 131-157 17928982-5 2007 Immune activation with increased production of proinflammatory cytokines activate the tryptophan- and serotonin-degradating enzyme indolamine-2,3-dioxygenase (IDO). Serotonin 102-111 indoleamine 2,3-dioxygenase 1 Homo sapiens 159-162 17928982-6 2007 The increased consumption of serotonin and its precursor tryptophan due to IDO activation may explain the reduced availability of serotonin in depression. Serotonin 29-38 indoleamine 2,3-dioxygenase 1 Homo sapiens 75-78 30995231-1 2019 Dihydropteridine reductase (QDPR) catalyzes the recycling of tetrahydrobiopterin (BH4), a cofactor in dopamine, serotonin, and phenylalanine metabolism. Serotonin 112-121 quinoid dihydropteridine reductase b, tandem duplicate 1 Danio rerio 0-26 17616645-3 2007 In comparison with acetylcholine (ACh) or serotonin (5-HT), ET induced a stronger and long-lasting contraction of both bronchioles and arterioles. Serotonin 42-51 endothelin 1 Mus musculus 60-62 19737523-4 2009 We show here that brainstem-derived serotonin (BDS) favors bone mass accrual following its binding to Htr2c receptors on ventromedial hypothalamic neurons and appetite via Htr1a and 2b receptors on arcuate neurons. Serotonin 36-45 5-hydroxytryptamine receptor 1A Homo sapiens 172-184 30866469-8 2019 Novel aspects in SCC tissue were increased in Vitamin B complex cofactors, serotonin and a reduction of gamma-aminobutyric acid (GABA). Serotonin 75-84 serpin family B member 3 Homo sapiens 17-20 19631608-5 2009 The ADP-induced secretion of platelet-derived growth factor (PDGF)-AB and serotonin (5-HT) were significantly suppressed by AT-III. Serotonin 74-83 serpin family C member 1 Homo sapiens 124-130 17826688-2 2007 5-HT(1A) receptors are expressed as somatodendritic autoreceptors in serotonin neurons of the raphe nuclei (presynaptic) and as postsynaptic receptors in cortical and subcortical serotonin terminal fields in the brain. Serotonin 69-78 5-hydroxytryptamine receptor 1A Homo sapiens 0-7 17826688-2 2007 5-HT(1A) receptors are expressed as somatodendritic autoreceptors in serotonin neurons of the raphe nuclei (presynaptic) and as postsynaptic receptors in cortical and subcortical serotonin terminal fields in the brain. Serotonin 179-188 5-hydroxytryptamine receptor 1A Homo sapiens 0-7 17663674-2 2007 Serotonin can be synthesised in the pulmonary endothelium with the rate-limiting step being the activity of tryptophan hydroxylase1 (Tph1). Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 108-131 17663674-2 2007 Serotonin can be synthesised in the pulmonary endothelium with the rate-limiting step being the activity of tryptophan hydroxylase1 (Tph1). Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 133-137 30641120-5 2019 Besides, Tyrosine Hydroxylase (TH) immunoreactive cells decreased in reserpine (RES) group in CA1 and serotonin (5-HT) immunoreactive cells decreased in RES group in CA1, CA3 and medial prefrontal cortex (mPFC). Serotonin 102-111 carbonic anhydrase 1 Rattus norvegicus 166-169 17661792-2 2007 We claim that PC follows serotonin depletion that raises the binding potential (p(B)) of the 5-HT(1A) receptor antagonist [carbonyl-(11)C]WAY-100635, which is reversible by selective serotonin re-uptake inhibitor (SSRI) treatment. Serotonin 25-34 5-hydroxytryptamine receptor 1A Homo sapiens 93-110 17661792-2 2007 We claim that PC follows serotonin depletion that raises the binding potential (p(B)) of the 5-HT(1A) receptor antagonist [carbonyl-(11)C]WAY-100635, which is reversible by selective serotonin re-uptake inhibitor (SSRI) treatment. Serotonin 183-192 5-hydroxytryptamine receptor 1A Homo sapiens 93-110 19623039-4 2009 The level of endothelin-converting enzyme was upregulated at that site where, upon exposure to serotonin, there were also increases in p47(phox), ROS, and ET-1 fluorescence intensities, and myosin light chain phosphorylation and RhoA activation were detected. Serotonin 95-104 pleckstrin Homo sapiens 135-138 19447286-1 2009 In an attempt to clarify conflicting results about serotonin (5-hydroxytryptamine, 5-HT) 5-HT(1A) and 5-HT(7) receptors in memory formation, their mRNA expression was determined by RT-PCR in key brain areas for explicit and implicit memory. Serotonin 51-60 5-hydroxytryptamine receptor 1A Homo sapiens 89-96 19356039-1 2007 Three neurotransmitters, namely adrenaline, serotonin and tryptamine inhibit the in vitro activity of several cytochrome P450 (CYP) isozymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A). Serotonin 44-53 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 142-148 30541912-10 2019 These results showed that the activation of 5-HT1A receptors in retinas facilitated presynaptic GABA release functions by suppressing cAMP-PKA signaling and decreasing PKA phosphorylation, which could lead to the de-excitation of RGC circuits and suppress excitotoxic processes in glaucoma.SIGNIFICANCE STATEMENT We found that serotonin (5-HT) receptors in the retina (5-HT1A receptors) were downregulated after intraocular pressure elevation. Serotonin 44-48 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 139-142 19356039-1 2007 Three neurotransmitters, namely adrenaline, serotonin and tryptamine inhibit the in vitro activity of several cytochrome P450 (CYP) isozymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A). Serotonin 44-53 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 150-156 19397907-1 2009 The serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) G protein-coupled receptors signal primarily through G alpha(q) to activate phospholipase C (PLC) and formation of inositol phosphates (IP) and diacylglycerol. Serotonin 4-13 heparan sulfate proteoglycan 2 Homo sapiens 140-143 30541912-10 2019 These results showed that the activation of 5-HT1A receptors in retinas facilitated presynaptic GABA release functions by suppressing cAMP-PKA signaling and decreasing PKA phosphorylation, which could lead to the de-excitation of RGC circuits and suppress excitotoxic processes in glaucoma.SIGNIFICANCE STATEMENT We found that serotonin (5-HT) receptors in the retina (5-HT1A receptors) were downregulated after intraocular pressure elevation. Serotonin 44-48 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 168-171 30450838-6 2019 Mechanistically, GCH1 overexpression increased BH4, nitric oxide and hydrogen peroxide, and these changes were associated with increased release of histamine and serotonin and degranulation of mast cells. Serotonin 162-171 GTP cyclohydrolase 1 Mus musculus 17-21 18562401-1 2009 Tardive dyskinesia (TD) is associated with polymorphisms of the dopamine D(3), serotonin 2A and 2C receptors (DRD3, HTR2A and HTR2C, respectively). Serotonin 79-88 dopamine receptor D3 Homo sapiens 110-114 19500158-1 2009 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 0-24 17605607-5 2007 RESULTS: In the absence of extracellular Ca(2+), maximal responses of veins to 5-HT, phenylephrine, ET-1 and PGF(2) were reduced by 80%, 50%, 50%, and 45%, respectively; responses of arteries to 5-HT, phenylephrine, and ET-1 were reduced by 95%, 90%, and 20%, respectively. Serotonin 195-199 endothelin 1 Equus caballus 100-104 17156118-2 2007 At 18 months of age, mice with constitutive reductions in BDNF expression show decreased serotonin innervation in the hippocampus compared with age-matched wildtype mice. Serotonin 89-98 brain derived neurotrophic factor Mus musculus 58-62 30423430-12 2019 Since OCT3 transports serotonin and tryptophan, impaired placental OCT3 function is one common mechanism that could persistently impact central serotonin systems and social behavior. Serotonin 22-31 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 6-10 17915535-5 2007 Their appearance was prevented, correspondingly, by serotonin and its lipophilic (or hydrophilic) analogs and antagonists of cannabinoid (CB1/CB2)-receptors. Serotonin 52-61 cannabinoid receptor 2 Homo sapiens 142-145 17446559-7 2007 In M-07e cells, serotonin exerted antiapoptotic effects (annexin V, caspase-3, and propidium iodide staining) and reduced mitochondria membrane potential damage. Serotonin 16-25 annexin A5 Homo sapiens 57-66 19500158-1 2009 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 26-30 19500158-1 2009 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and allelic variations at the TPH1 locus have been implicated in the pathophysiology of depression. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 117-121 30423430-12 2019 Since OCT3 transports serotonin and tryptophan, impaired placental OCT3 function is one common mechanism that could persistently impact central serotonin systems and social behavior. Serotonin 22-31 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 67-71 17944104-3 2007 5-HT2A and MAOA genes, regulating activity of serotonin, influence on subjective time flow. Serotonin 46-55 monoamine oxidase A Homo sapiens 11-15 30423430-12 2019 Since OCT3 transports serotonin and tryptophan, impaired placental OCT3 function is one common mechanism that could persistently impact central serotonin systems and social behavior. Serotonin 144-153 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 67-71 30707744-0 2019 Retraction: The Cellular Distribution of Serotonin Transporter Is Impeded on Serotonin-Altered Vimentin Network. Serotonin 41-50 vimentin Homo sapiens 95-103 20144064-1 2007 The histamine H(3) receptor is involved in the central and peripheral regulation of levels of histamine and other neurotransmitters (e.g., acetylcholine, noradrenaline, dopamine, serotonin and GABA), which sets it up as a target in the treatment of various CNS (e.g., depression, schizophrenia, ADHD, dementia, neuropathic pain and sleep disorders), metabolic syndrome (e.g., obesity) and allergic disorders. Serotonin 179-188 histamine receptor H3 Homo sapiens 4-27 19283364-4 2009 OBJECTIVES: Although BMY-14802 is widely used as a sigma-1 antagonist, it is also an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. Serotonin 96-105 5-hydroxytryptamine receptor 1A Homo sapiens 107-148 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 56-65 tryptophan hydroxylase 1 Homo sapiens 69-93 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 56-65 tryptophan hydroxylase 1 Homo sapiens 95-99 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 69-93 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 95-99 17325130-11 2007 Upon coexpression, serotonin-induced 5-HT(2B) receptor internalization became partially Caveolin1-dependent, and serotonin-induced 5-HT(1B) receptor internalization became entirely Caveolin1-independent in a protein kinase Cepsilon-dependent fashion. Serotonin 19-28 caveolin 1, caveolae protein Mus musculus 88-97 17325130-11 2007 Upon coexpression, serotonin-induced 5-HT(2B) receptor internalization became partially Caveolin1-dependent, and serotonin-induced 5-HT(1B) receptor internalization became entirely Caveolin1-independent in a protein kinase Cepsilon-dependent fashion. Serotonin 113-122 caveolin 1, caveolae protein Mus musculus 181-190 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 69-93 29685068-4 2019 Animal models, particularly mouse models carrying variants of AD-related gene(s), many of which lead to an accumulation of Abeta, suggest that a fundamental shift in depression-related monoaminergic systems (including serotonin and noradrenaline) is a strong indicator of the altered cellular function associated with the earlier(est) stages of AD-related pathology. Serotonin 218-227 amyloid beta (A4) precursor protein Mus musculus 123-128 19286424-3 2009 The rate-limiting enzyme in the synthesis of peripheral serotonin is tryptophan hydroxylase 1 (TPH1), serotonin can mediate pulmonary arterial smooth muscle cell proliferation via the serotonin transporter (SERT) and serotonin can induce pulmonary vasoconstriction via the 5-HT1B receptor in man. Serotonin 102-111 tryptophan hydroxylase 1 Homo sapiens 95-99 18928402-2 2009 Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT). Serotonin 283-292 glycogen synthase kinase 3 beta Mus musculus 203-229 17456220-11 2007 In addition, instillation of serotonin to immunized mice induced eosinophil recruitment to BAL, Th2 cytokine production and fibronectin release in lung as well as collagen deposition. Serotonin 29-38 fibronectin 1 Mus musculus 124-135 17303090-2 2007 The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradrenaline (NA), dopamine (DA) and nitric oxide (NO). Serotonin 76-85 gonadotropin releasing hormone 1 Rattus norvegicus 15-19 18928402-2 2009 Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT). Serotonin 283-292 glycogen synthase kinase 3 beta Mus musculus 231-235 17203304-8 2007 The most significant models contributing to serotonin distribution were found for interactions between TPH1 rs4537731 and SLC6A4 haplotypes (P = 0.002) and between HTR1D rs6300 and SLC6A4 haplotypes (P = 0.013). Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 103-107 30336258-4 2019 To address this gap, we employed a nocturnal mouse food refusal model to test the hypothesis that neurotransmitters 5-hydroxytryptamine (5-HT) and substance P (SP) mediate anorexia induction by T-2 toxin. Serotonin 116-135 brachyury 2 Mus musculus 194-197 16900104-4 2007 As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity. Serotonin 46-55 neural cell adhesion molecule 1 Rattus norvegicus 25-29 16900104-4 2007 As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity. Serotonin 46-55 neural cell adhesion molecule 1 Rattus norvegicus 146-150 19903352-5 2009 METHODS: Serotonin biosynthetic capacity was analyzed in human breast tumor tissue microarrays using immunohistochemistry for tryptophan hydroxylase 1 (TPH1). Serotonin 9-18 tryptophan hydroxylase 1 Homo sapiens 126-150 19903352-5 2009 METHODS: Serotonin biosynthetic capacity was analyzed in human breast tumor tissue microarrays using immunohistochemistry for tryptophan hydroxylase 1 (TPH1). Serotonin 9-18 tryptophan hydroxylase 1 Homo sapiens 152-156 16900104-4 2007 As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity. Serotonin 109-118 neural cell adhesion molecule 1 Rattus norvegicus 25-29 30468670-5 2019 Peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (Tph), which exists in two different isoforms: Tph2 being responsible for serotonin synthesis in neurons and Tph1 for generation of serotonin in peripheral organs. Serotonin 11-20 tryptophan hydroxylase 1 Homo sapiens 182-186 16900104-4 2007 As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity. Serotonin 109-118 neural cell adhesion molecule 1 Rattus norvegicus 146-150 17184738-8 2007 These observations demonstrate that the EC cell-related BON cells express functional CRF2 receptors linked to the release of serotonin. Serotonin 125-134 corticotropin releasing hormone receptor 2 Homo sapiens 85-89 17295220-4 2007 Common alleles of some serotonin pathway genes, including those involved in its degradation (monoamine oxidase A, MAOA), or its re-uptake into pre-synaptic neurones (serotonin transporter, SERT) have been shown to confer functional variation. Serotonin 23-32 monoamine oxidase A Homo sapiens 93-112 19209222-2 2009 Here we show that variants of two genes that regulate dopamine and serotonin neurotransmission and have been previously linked to emotional behavior, anxiety and addiction (5-HTTLPR and DRD4) are significant determinants of risk taking in investment decisions. Serotonin 67-76 dopamine receptor D4 Homo sapiens 186-190 30005281-2 2018 The balance of inflammatory signals in the tryptophan pathway can skew the activity of indoleamine-pyrrole 2,3 dioxygenase (IDO1) towards the metabolization of tryptophan into kynurenine (rather than serotonin), and towards neuroprotective or neurotoxic metabolites. Serotonin 200-209 indoleamine 2,3-dioxygenase 1 Mus musculus 87-122 19010890-5 2008 Specifically, there was an increased expression of tryptophan hydroxylase 1 and a suppression of monoamine oxidase A expression (enzymes responsible for the synthesis and degradation of serotonin, respectively) in cholangiocarcinoma. Serotonin 186-195 monoamine oxidase A Homo sapiens 97-116 19198338-1 2008 We report the highly selective and sensitive voltammetric dopamine quantification in the presence of ascorbic acid and serotonin by using glassy carbon electrodes modified with a dispersion of multi-wall carbon nanotubes (MWCNT) in polyethylenimine, PEI (GCE/MWCNT-PEI). Serotonin 119-128 aminomethyltransferase Homo sapiens 255-268 17088403-4 2007 We show that acetaminophen indirectly stimulates spinal 5-hydroxytryptamine (5-HT)1A receptors in the formalin test, thereby increasing transcript and protein levels of low-affinity neurotrophin receptor, insulin-like growth factor-1 (IGF-1) receptor alpha subunit, and growth hormone receptor and reducing the amount of somatostatin 3 receptor (sst3R) mRNA. Serotonin 56-75 insulin-like growth factor 1 Rattus norvegicus 235-240 30005281-2 2018 The balance of inflammatory signals in the tryptophan pathway can skew the activity of indoleamine-pyrrole 2,3 dioxygenase (IDO1) towards the metabolization of tryptophan into kynurenine (rather than serotonin), and towards neuroprotective or neurotoxic metabolites. Serotonin 200-209 indoleamine 2,3-dioxygenase 1 Mus musculus 124-128 19198338-3 2008 The sensitivities for dopamine in the presence and absence of 1.0 mM ascorbic acid and serotonin were (2.18 +/- 0.03) x 10(5) microAM(-1) (r = 0.9998); and (2.10 +/- 0.07) x 10(5) miroAM(-1) (r=0.9985), respectively, demonstrating the excellent performance of the GCE/MWCNT-PEI. Serotonin 87-96 aminomethyltransferase Homo sapiens 264-277 17110048-3 2007 Recently plasma membrane monoamine transporter (PMAT), a transporter from the SLC29 (equilibrative nucleoside transporter) family, was shown to transport in vitro monoaminergic neurotransmitters, in particular dopamine and serotonin, nearly as efficiently as the high-affinity transporters. Serotonin 223-232 solute carrier family 29 member 4 Homo sapiens 48-52 30373627-13 2018 Additionally, IDO1 and SERT, key serotonin-system-related genes activated by proinflammatory cytokines, were upregulated in HT mice, accompanied by reduced frontal cortex serotonin levels. Serotonin 33-42 indoleamine 2,3-dioxygenase 1 Mus musculus 14-18 16806099-5 2007 RESULTS: A suggestive association of sequence variations in genes responsible for the synthesis (TPH), recognition (5-HTR2A), and degradation (MAOA) of serotonin with depression symptomatology was found, although the effect was generally restricted to men. Serotonin 152-161 monoamine oxidase A Homo sapiens 143-147 18971477-3 2008 Monoamine oxidase A (MAO-A) is a key regulator of serotonin metabolism, and polymorphic variation in the X-linked MAO-A gene influences its expression. Serotonin 50-59 monoamine oxidase A Homo sapiens 0-19 18971477-3 2008 Monoamine oxidase A (MAO-A) is a key regulator of serotonin metabolism, and polymorphic variation in the X-linked MAO-A gene influences its expression. Serotonin 50-59 monoamine oxidase A Homo sapiens 21-26 30373627-13 2018 Additionally, IDO1 and SERT, key serotonin-system-related genes activated by proinflammatory cytokines, were upregulated in HT mice, accompanied by reduced frontal cortex serotonin levels. Serotonin 171-180 indoleamine 2,3-dioxygenase 1 Mus musculus 14-18 18971477-3 2008 Monoamine oxidase A (MAO-A) is a key regulator of serotonin metabolism, and polymorphic variation in the X-linked MAO-A gene influences its expression. Serotonin 50-59 monoamine oxidase A Homo sapiens 114-119 16876135-1 2007 BACKGROUND: Past studies in the neurobiology of suicide have reported alterations in serotonin and downstream effectors, such as Akt/protein kinase B. Serotonin 85-94 protein tyrosine kinase 2 beta Homo sapiens 133-149 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Serotonin 202-211 monoamine oxidase A Homo sapiens 25-44 17095746-7 2007 MEASUREMENTS AND MAIN RESULTS: Estrogen receptor-alpha knockout mice exhibit a variety of lung function abnormalities and have enhanced airway responsiveness to inhaled methacholine and serotonin under basal conditions. Serotonin 186-195 estrogen receptor 1 (alpha) Mus musculus 31-54 30003648-4 2018 The mitochondrial enzyme monoamine oxidase-A (MAO-A) is a relevant source of ROS in the heart through the formation of H2 O2 derived from the degradation of its main substrates, norepinephrine (NE) and serotonin. Serotonin 202-211 monoamine oxidase A Homo sapiens 46-51 29760450-5 2018 Cav-3 deficiency fully abrogated serotonin-induced constriction of extrapulmonary airways in organ baths while leaving intrapulmonary airways unaffected, as assessed in precision cut lung slices. Serotonin 33-42 caveolin 3 Mus musculus 0-5 17187587-1 2007 Sumatriptan, a 5-hydroxytryptamine(1D) (5-HT(1D))-receptor agonist used in the treatment in migraine, inhibits gastric motility via the enteric nervous system. Serotonin 15-34 5-hydroxytryptamine receptor 1D Cavia porcellus 40-58 18675266-0 2008 Antidepressant-like behavioral effects of IGF-I produced by enhanced serotonin transmission. Serotonin 69-78 insulin-like growth factor 1 Rattus norvegicus 42-47 18675266-8 2008 Depletion of serotonin, by the tryptophan hydroxylase inhibitor para-chlorophenylalanine, blocked the antidepressant-like effects of IGF-I. Serotonin 13-22 insulin-like growth factor 1 Rattus norvegicus 133-138 18675266-9 2008 Administration of IGF-I increased basal serotonin levels in the ventral hippocampus and altered the effects of acute citalopram. Serotonin 40-49 insulin-like growth factor 1 Rattus norvegicus 18-23 18675266-12 2008 Thus, IGF-I administration initiates a long-lasting cascade of neurochemical effects involving increased serotonin levels that results in antidepressant-like behavioral effects. Serotonin 105-114 insulin-like growth factor 1 Rattus norvegicus 6-11 17064686-7 2006 Treatment with serotonin caused strong inductions in the phosphorylation states of Ser(63)-ATF-1 and Ser(133)-CREB. Serotonin 15-24 activating transcription factor 1 Homo sapiens 91-96 29505805-3 2018 Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane enzyme which is involved in the metabolic pathway of serotonin degradation. Serotonin 116-125 monoamine oxidase A Homo sapiens 0-19 16958027-1 2006 The TPH1 and TPH2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. Serotonin 70-79 tryptophan hydroxylase 1 Homo sapiens 4-8 16958027-1 2006 The TPH1 and TPH2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. Serotonin 98-107 tryptophan hydroxylase 1 Homo sapiens 4-8 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Serotonin 123-132 monoamine oxidase A Homo sapiens 0-19 18361446-1 2008 Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin. Serotonin 123-132 monoamine oxidase A Homo sapiens 21-25 29505805-3 2018 Monoamine oxidase A (MAO-A) is an outer mitochondrial membrane enzyme which is involved in the metabolic pathway of serotonin degradation. Serotonin 116-125 monoamine oxidase A Homo sapiens 21-26 17141627-0 2006 Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses. Serotonin 0-9 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 22-28 29666456-0 2018 Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR. Serotonin 0-9 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 51-57 17141627-2 2006 Here we describe how serotonin (5HT) governs stress behavior by regulating DAF-2 insulin/IGF-1 receptor signaling to the DAF-16/FOXO transcription factor at the nexus of development, metabolism, immunity, and stress responses in C. elegans. Serotonin 21-30 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 121-127 17141627-2 2006 Here we describe how serotonin (5HT) governs stress behavior by regulating DAF-2 insulin/IGF-1 receptor signaling to the DAF-16/FOXO transcription factor at the nexus of development, metabolism, immunity, and stress responses in C. elegans. Serotonin 32-35 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 121-127 17141627-3 2006 Serotonin-deficient tph-1 mutants, like daf-2 mutants, exhibit DAF-16 nuclear accumulation and constitutive physiological stress states. Serotonin 0-9 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 63-69 18721140-5 2008 The release of the 35 k Da annexin II by matrilysin was significantly enhanced in the presence of serotonin or heparin. Serotonin 98-107 matrix metallopeptidase 7 Homo sapiens 41-51 29642911-8 2018 RESULTS: We demonstrate that GnRH and LH inhibitory neurotransmitters - serotonin, dopamine, GABA and acetylcholine - are reduced while glutamate, a major stimulator of GnRH and LH release, is increased in the PCOS condition. Serotonin 72-81 gonadotropin releasing hormone 1 Rattus norvegicus 29-33 18981671-1 2008 Tryptophan hydroxylase (TPH) serves as the rate-limiting enzyme in the biosynthesis of serotonin, and two forms of TPH genes, TPH1 and TPH2, have been reported with specific nucleotide sequences and expression patterns. Serotonin 87-96 tryptophan hydroxylase 2 Canis lupus familiaris 135-139 18783955-0 2008 N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands. Serotonin 74-83 5-hydroxytryptamine receptor 1A Homo sapiens 84-101 17141627-4 2006 Exogenous 5HT and fluoxetine (Prozac) prevented DAF-16 nuclear accumulation in wild-type animals under stresses. Serotonin 10-13 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 48-54 17034589-3 2006 In this study we examined the effect of serotonin, a prototypic mediator of allergic inflammation released mainly by activated platelets at the inflammatory site, on the granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4-driven differentiation of monocytes into monocyte-derived DC. Serotonin 40-49 colony stimulating factor 2 Homo sapiens 170-218 17034589-3 2006 In this study we examined the effect of serotonin, a prototypic mediator of allergic inflammation released mainly by activated platelets at the inflammatory site, on the granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4-driven differentiation of monocytes into monocyte-derived DC. Serotonin 40-49 colony stimulating factor 2 Homo sapiens 220-226 16894392-5 2006 The increased production of proinflammatory cytokines such as IL-1beta, TNF-alpha or IL-18 resulting from stroke may lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia. Serotonin 297-306 indoleamine 2,3-dioxygenase 1 Homo sapiens 230-257 17009264-2 2006 Two serotonin-related gene polymorphisms, the serotonin receptor 1A (5-HT1A) polymorphism at -1019C>G and the serotonin transporter LS polymorphism, have been reported to affect stress-related behaviors. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 69-75 18653660-10 2008 Taken together, these results suggest that serotonin, by cooperating with mGluRs, regulates synaptic plasticity through a mechanism dependent on p38 MAPK/Rab5-mediated enhancement of AMPA receptor internalization in a clathrin/dynamin-dependent manner. Serotonin 43-52 RAB5A, member RAS oncogene family Homo sapiens 154-158 29642911-8 2018 RESULTS: We demonstrate that GnRH and LH inhibitory neurotransmitters - serotonin, dopamine, GABA and acetylcholine - are reduced while glutamate, a major stimulator of GnRH and LH release, is increased in the PCOS condition. Serotonin 72-81 gonadotropin releasing hormone 1 Rattus norvegicus 169-173 29543650-6 2018 IDO catabolizes tryptophan, the amino acid precursor of serotonin and melatonin, to the metabolites collectively called TRYCATs. Serotonin 56-65 indoleamine 2,3-dioxygenase 1 Homo sapiens 0-3 18840973-2 2008 They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. Serotonin 59-68 solute carrier family 6 member 3 Canis lupus familiaris 103-109 16458487-1 2006 The firing rate of dorsal raphe serotonergic neurons is modulated by somatodendritic 5-hydroxytryptamine 1A (HTR1A) autoreceptors. Serotonin 85-104 5-hydroxytryptamine receptor 1A Homo sapiens 109-114 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 22-31 tryptophan hydroxylase 1 Homo sapiens 71-75 16847459-1 2006 Tryptophan hydroxylase-2 (TPH2) is a newly identified second form of TPH responsible for serotonin synthesis in the brain and has been increasingly implicated as a contributor to the etiology of various psychiatric disorders. Serotonin 89-98 tryptophan hydroxylase 2 Macaca mulatta 0-24 18583156-2 2008 Several lines of evidence indicate that 5HT(1A) receptors exert a negative feedback in the synthesis and release of serotonin. Serotonin 116-125 5-hydroxytryptamine receptor 1A Homo sapiens 40-46 18583156-4 2008 This study aims to assess the correlation between serotonin synthesis and 5-HT(1A) receptor binding using positron emission tomography (PET) in humans. Serotonin 50-59 5-hydroxytryptamine receptor 1A Homo sapiens 74-91 16847459-1 2006 Tryptophan hydroxylase-2 (TPH2) is a newly identified second form of TPH responsible for serotonin synthesis in the brain and has been increasingly implicated as a contributor to the etiology of various psychiatric disorders. Serotonin 89-98 tryptophan hydroxylase 2 Macaca mulatta 26-30 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 71-75 29468941-4 2018 Pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (TPH1) is increased in patients with PAH and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (PASMCs), In humans, serotonin can enter PASMCs via the serotonin transporter (SERT) or activate the 5-HT1B receptor; 5-HT1B activation and SERT activity cooperate to induce PASMC contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. Serotonin 115-124 tryptophan hydroxylase 1 Homo sapiens 71-75 29367404-5 2018 Using unbiased translational profiling in mouse brain, we show that phospho-eIF4E differentially regulates the translation of a subset of mRNAs linked to inflammation, the extracellular matrix, pituitary hormones, and the serotonin pathway. Serotonin 222-231 eukaryotic translation initiation factor 4E Mus musculus 76-81 16894346-0 2006 Mutations within the selectivity filter of the NMDA receptor-channel influence voltage dependent block by 5-hydroxytryptamine. Serotonin 106-125 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 47-60 16894346-2 2006 Inhibition of NMDA receptor currents by 5-hydroxytryptamine (5-HT) indicated that 5-HT, similar to Mg2+, binds within the membrane electric field. Serotonin 40-59 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 14-27 18505819-1 2008 In Aplysia californica, the serotonin-mediated translocation of protein kinase C (PKC) Apl II to neuronal membranes is important for synaptic plasticity. Serotonin 28-37 calcium-independent protein kinase C Aplysia californica 87-93 18505819-5 2008 In Aplysia neurons, the inhibition of endogenous PA production by 1-butanol inhibited the physiological translocation of PKC Apl II by serotonin in the cell body and at the synapse but not the translocation of PKC Apl II-R273H. Serotonin 135-144 calcium-independent protein kinase C Aplysia californica 125-131 18665222-2 2008 In an earlier study, we found that serotonin (5-HT), acting through the 5-HT1A receptor subtype, promotes axonal transport of mitochondria in cultured hippocampal neurons by increasing Akt activity, and consequently decreasing glycogen synthase kinase (GSK3beta) activity. Serotonin 35-44 5-hydroxytryptamine receptor 1A Homo sapiens 72-87 29367404-12 2018 These phenotypes are accompanied by selective translation of extracellular matrix, pituitary hormones, and serotonin pathway genes, in eIF4E phospho-mutant mice. Serotonin 107-116 eukaryotic translation initiation factor 4E Mus musculus 135-140 16873718-5 2006 In contrast, serotonin transport by ENT4 was relatively insensitive to pH. Serotonin 13-22 solute carrier family 29 member 4 Homo sapiens 36-40 29362726-11 2018 In conclusion, estradiol may improve perimenopause symptoms by increasing progesterone and boosting serotonin pathway from the caudal DRN to the dorsal HPC potentially through an increment in ERbeta expression in the DRN. Serotonin 100-109 estrogen receptor 2 Rattus norvegicus 192-198 16873718-7 2006 We hypothesize that ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia. Serotonin 66-75 solute carrier family 29 member 4 Homo sapiens 20-24 16942467-9 2006 Serotonin was present in trigeminal neurons containing CGRP, a potent vasoactive neuropeptide, peripherin, an intermediate filament present in neurons with unmyelinated axons, neurofilament H, which is present in neurons with myelinated axons, and in neurons binding IB4, a marker of nonpeptidergic nociceptors. Serotonin 0-9 peripherin Homo sapiens 95-105 17081078-3 2006 Several putative molecular targets for treating cognition in schizophrenia show promise, such as treatments that act on the D(1) receptor of the dopamine system; the 5HT(1A), 5HT(2A), and 5HT(6), receptors of the serotonin system; and ampakines, Glycine/D-cycloserine, D-serine, and mGluR 2/3 agonists of the glutamatergic system. Serotonin 213-222 5-hydroxytryptamine receptor 1A Homo sapiens 166-172 18418630-5 2008 The immuno-positive results of such an antibody in brains from diverse orders of insects suggest that specific tryptophan hydroxylase responsible for central serotonin synthesis is probably present in the brains of all insects. Serotonin 158-167 Tryptophan hydroxylase Drosophila melanogaster 111-133 17711450-2 2008 The serotonin 5-hydroxytryptamine(1A) (5-HT(1A)) receptor gene sequence in typical seasonal hibernator, ground squirrel (Spermophilus undulatus), was specified. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 39-46 17711450-2 2008 The serotonin 5-hydroxytryptamine(1A) (5-HT(1A)) receptor gene sequence in typical seasonal hibernator, ground squirrel (Spermophilus undulatus), was specified. Serotonin 14-33 5-hydroxytryptamine receptor 1A Homo sapiens 39-46 30430940-4 2018 RESULTS: This review shows that sex may interact with many serotonin functions thereby modulating anxiety, including 5-HT1A and 5-HT2C receptors, 5-HT transporter and central 5-HT concentrations and metabolism. Serotonin 59-68 5-hydroxytryptamine receptor 1A Homo sapiens 117-162 16737974-2 2006 5-hydroxy-tryptamine (5-HT) resulted in rapid activation of TACE, HB-EGF shedding, EGFR activation, ERK phosphorylation, and longer term increases in DNA content in mesangial cells. Serotonin 0-20 heparin binding EGF like growth factor Homo sapiens 66-72 16737974-2 2006 5-hydroxy-tryptamine (5-HT) resulted in rapid activation of TACE, HB-EGF shedding, EGFR activation, ERK phosphorylation, and longer term increases in DNA content in mesangial cells. Serotonin 0-20 EPH receptor B2 Homo sapiens 100-103 29251109-8 2017 Because both serotonin and RYR can enhance Purkinje cell maturation, these effects may account for the therapeutic benefits mediated by intracranial hOEC transplantation in SCA3 mice. Serotonin 13-22 ataxin 3 Mus musculus 173-177 16805803-1 2006 We present evidence that the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor antagonist, N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide (WAY-100635), can induce receptor internalization in a human (h)5-HT(1A) receptor Chinese hamster ovary (CHO-K1) cell system. Serotonin 29-48 5-hydroxytryptamine receptor 1A Homo sapiens 54-72 16805803-1 2006 We present evidence that the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor antagonist, N-{2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl}-N-(2-pyridinyl)cyclohexanecarboxamide (WAY-100635), can induce receptor internalization in a human (h)5-HT(1A) receptor Chinese hamster ovary (CHO-K1) cell system. Serotonin 29-48 5-hydroxytryptamine receptor 1A Homo sapiens 235-252 16804755-0 2006 Regional variations of 5HT concentrations in Rorasg (staggerer) mutants. Serotonin 23-26 RAR-related orphan receptor alpha Mus musculus 53-62 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Serotonin 104-113 monoamine oxidase A Homo sapiens 0-19 18388730-1 2008 Monoamine oxidase A (MAOA) enzymatically degrades biogenic amines such as norepinephrine, dopamine, and serotonin, and plays a key role in the regulation of their neurotransmission. Serotonin 104-113 monoamine oxidase A Homo sapiens 21-25 16804755-2 2006 In Rora(sg) cerebellum, 5HT concentrations increased relative to controls, while tryptophan concentrations decreased. Serotonin 24-27 RAR-related orphan receptor alpha Mus musculus 3-7 27457815-4 2017 Here we show that chronic restraint stress induces the selective loss of p11 (also known as annexin II light chain, S100A10), a multifunctional protein binding to 5-HT receptors, in layer II/III neurons of the prelimbic cortex (PrL), as well as depression-like behaviors, both of which are reversed by selective serotonin reuptake inhibitors (SSRIs) and the tricyclic class of antidepressant (TCA) agents. Serotonin 312-321 annexin A2 Mus musculus 92-102 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Serotonin 112-121 monoamine oxidase A Homo sapiens 16-35 18227761-1 2008 BACKGROUND: The monoamine oxidase-A (MAOA) gene plays a vital role in the metabolism of neurotransmitters, e.g, serotonin, norepinephrine, and dopamine. Serotonin 112-121 monoamine oxidase A Homo sapiens 37-41 28931427-1 2017 BACKGROUND: Serotonin receptor 5-HT6 is involved in cognition and Alzheimer"s disease (AD) development. Serotonin 12-21 5-hydroxytryptamine (serotonin) receptor 6 Mus musculus 31-36 18036835-9 2008 Sex differences in 5-HT(1A) receptor and 5-HTT BP(ND) may reflect biological distinctions in the serotonin system contributing to sex differences in the prevalence of psychiatric disorders such as depression and anxiety. Serotonin 97-106 5-hydroxytryptamine receptor 1A Homo sapiens 19-36 16940699-10 2006 U-II also activates nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and plasminogen activator inhibitor-1 in human VSMCs, and stimulates VSMC proliferation with synergistic effects observed when combined with oxidized low-density lipoprotein, lysophosphatidylcholine, reactive oxygen species or serotonin. Serotonin 307-316 urotensin 2 Homo sapiens 0-4 28677022-2 2017 Our aim was to determine among cancer patients the correlation of the 4T score and H-PF4 ab with the serotonin release assay (SRA). Serotonin 101-110 zinc finger protein 85 Homo sapiens 83-88 16495364-3 2006 In vitro data suggest that serotonin (5-HT), through the 5-HT2A receptor subtype, plays a key role in controlling the excitability of IHMNs. Serotonin 27-36 5-hydroxytryptamine receptor 2A Canis lupus familiaris 57-72 16442134-7 2006 Increased dopamine turnover in cortex and reduced dopamine and serotonin turnover in amygdala were observed in both male and female Wa-1 mice. Serotonin 63-72 transforming growth factor alpha Mus musculus 132-136 18405062-6 2008 In addition, when TPH-cc and MAOA-4 were combined as "high 5HT" genotypes, a correlative increase in PSL was observed with the increase in the number of "high 5HT" genotypes. Serotonin 59-62 monoamine oxidase A Homo sapiens 29-33 18405062-6 2008 In addition, when TPH-cc and MAOA-4 were combined as "high 5HT" genotypes, a correlative increase in PSL was observed with the increase in the number of "high 5HT" genotypes. Serotonin 159-162 monoamine oxidase A Homo sapiens 29-33 17888505-1 2008 Serotonin 5-HT1A and 5-HT1B/1D receptors control serotonin (5-HT) release and are targets for the pharmacological treatment of psychiatric disorders. Serotonin 0-9 5-hydroxytryptamine receptor 1A Cavia porcellus 10-16 17888505-1 2008 Serotonin 5-HT1A and 5-HT1B/1D receptors control serotonin (5-HT) release and are targets for the pharmacological treatment of psychiatric disorders. Serotonin 49-58 5-hydroxytryptamine receptor 1A Cavia porcellus 10-16 16537434-4 2006 Initial studies of 5-hydroxytryptamine (5-HT)(2A) receptor signaling in fibroblasts obtained from RSK2 wild-type (+/+) and knockout (-/-) mice showed that 5-HT(2A) receptor-mediated phosphoinositide hydrolysis and both basal and 5-HT-stimulated extracellular signal-regulated kinase 1/2 phosphorylation are augmented in RSK2 knockout fibroblasts. Serotonin 19-38 ribosomal protein S6 kinase polypeptide 3 Mus musculus 98-102 16537434-4 2006 Initial studies of 5-hydroxytryptamine (5-HT)(2A) receptor signaling in fibroblasts obtained from RSK2 wild-type (+/+) and knockout (-/-) mice showed that 5-HT(2A) receptor-mediated phosphoinositide hydrolysis and both basal and 5-HT-stimulated extracellular signal-regulated kinase 1/2 phosphorylation are augmented in RSK2 knockout fibroblasts. Serotonin 19-38 ribosomal protein S6 kinase polypeptide 3 Mus musculus 320-324 28599322-4 2017 The MAO-A upregulation resulted in increased 5-hydroxyindoleacetic acid/serotonin ratio, oxidative stress, leading to NF-kappaB activation, inflammation and apoptosis. Serotonin 72-81 monoamine oxidase A Homo sapiens 4-9 17094659-0 2006 [Effect of nociceptin on histamine and serotonin release in the central nervous system]. Serotonin 39-48 prepronociceptin Rattus norvegicus 11-21 17094659-3 2006 administered NC (5.5 nmol/rat) on histamine and serotonin levels in blood plasma, CSF and brain areas (hypothalamus and hippocampus) was studies and compared to the effect of the mast cell degranulator Compound 48/80(100microg/kg, i.c.v.) Serotonin 48-57 prepronociceptin Rattus norvegicus 13-15 18772047-5 2008 Suppressing the activity of these 5-HT inputs to the striatum via presynaptic 5-HT(1A) agonists may reduce LID. Serotonin 34-38 5-hydroxytryptamine receptor 1A Homo sapiens 78-85 17976961-1 2007 Using PET neuroimaging, we demonstrated that four frontotemporal lobar dementia (FTLD) patients had significantly decreased serotonin 5-HT(1A) binding potential (BP) compared with controls in all 10 brain regions examined. Serotonin 124-133 5-hydroxytryptamine receptor 1A Homo sapiens 134-141 28599322-5 2017 Also, the expression of cytokine-responsive indoleamine 2,3-dioxygenase-1 (IDO-1) was significantly augmented in hypoxia, resulting in increased kynurenine/tryptophan ratio and lowered serotonin level in the hippocampus. Serotonin 185-194 indoleamine 2,3-dioxygenase 1 Homo sapiens 75-80 16409475-2 2006 5-Hydroxytryptamine (5-HT) is a potent vasoactive and platelet-aggregating substance that is predominantly mediated by 5-HT2A receptor. Serotonin 0-19 5-hydroxytryptamine receptor 2A Oryctolagus cuniculus 119-134 16409475-2 2006 5-Hydroxytryptamine (5-HT) is a potent vasoactive and platelet-aggregating substance that is predominantly mediated by 5-HT2A receptor. Serotonin 21-25 5-hydroxytryptamine receptor 2A Oryctolagus cuniculus 119-134 28599322-9 2017 Collectively, the MAO-A upregulation induced by chronic intermittent hypoxia plays significant pathogenic role in oxidative stress, inflammation and IDO-1 activation resulting in serotonin depletion and neurodegeneration. Serotonin 179-188 monoamine oxidase A Homo sapiens 18-23 28599322-9 2017 Collectively, the MAO-A upregulation induced by chronic intermittent hypoxia plays significant pathogenic role in oxidative stress, inflammation and IDO-1 activation resulting in serotonin depletion and neurodegeneration. Serotonin 179-188 indoleamine 2,3-dioxygenase 1 Homo sapiens 149-154 28555112-0 2017 Caveolin-1: Functional Insights into Its Role in Muscarine- and Serotonin-Induced Smooth Muscle Constriction in Murine Airways. Serotonin 64-73 caveolin 1, caveolae protein Mus musculus 0-10 16452654-11 2006 Moreover, activation of raphe 5-HT1a autoreceptors, which inhibits serotonin release, attenuated LTP induction even in familiar environments. Serotonin 67-76 5-hydroxytryptamine receptor 1A Homo sapiens 30-36 28185898-0 2017 SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action. Serotonin 40-49 sirtuin 2 Mus musculus 0-5 16302021-2 2006 The firing rate of dorsal raphe serotonergic neurons is controlled by somatodendritic 5-hydroxytryptamine 1A (HTR1A) autoreceptors, and desensitization of these receptors is implicated in the antidepressant mechanism of selective serotonin reuptake inhibitors. Serotonin 86-105 5-hydroxytryptamine receptor 1A Homo sapiens 110-115 16302021-2 2006 The firing rate of dorsal raphe serotonergic neurons is controlled by somatodendritic 5-hydroxytryptamine 1A (HTR1A) autoreceptors, and desensitization of these receptors is implicated in the antidepressant mechanism of selective serotonin reuptake inhibitors. Serotonin 230-239 5-hydroxytryptamine receptor 1A Homo sapiens 110-115 17989282-3 2007 To identify genes downstream of BDNF that may play roles in psychiatric disorders, we examined a subset of BDNF-induced genes also regulated by 5-HT (serotonin), which includes the neuropeptide VGF (nonacronymic). Serotonin 150-159 brain derived neurotrophic factor Mus musculus 107-111 28443016-5 2017 Interestingly, (i) the expression of three of these six genes (COMT, DBH, NOS1) are highly variable; (ii) three of these six genes (COMT, DBH, TPH1) are involved in DA or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (AR, BDNF, COMT, DBH, NOS1) have been implicated in the development, onset and/or propagation of schizophrenia. Serotonin 171-180 dopamine beta-hydroxylase Homo sapiens 69-72 28443016-5 2017 Interestingly, (i) the expression of three of these six genes (COMT, DBH, NOS1) are highly variable; (ii) three of these six genes (COMT, DBH, TPH1) are involved in DA or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (AR, BDNF, COMT, DBH, NOS1) have been implicated in the development, onset and/or propagation of schizophrenia. Serotonin 171-180 dopamine beta-hydroxylase Homo sapiens 138-141 16369834-2 2006 The existence of inverse agonists that retard learning through an action at the 5-HT2A receptor suggests the existence of constitutive activity at that receptor and that depletion of serotonin should have minimal effects on learning. Serotonin 183-192 5-hydroxytryptamine receptor 2A Oryctolagus cuniculus 80-95 28443016-5 2017 Interestingly, (i) the expression of three of these six genes (COMT, DBH, NOS1) are highly variable; (ii) three of these six genes (COMT, DBH, TPH1) are involved in DA or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (AR, BDNF, COMT, DBH, NOS1) have been implicated in the development, onset and/or propagation of schizophrenia. Serotonin 171-180 tryptophan hydroxylase 1 Homo sapiens 143-147 28443016-5 2017 Interestingly, (i) the expression of three of these six genes (COMT, DBH, NOS1) are highly variable; (ii) three of these six genes (COMT, DBH, TPH1) are involved in DA or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (AR, BDNF, COMT, DBH, NOS1) have been implicated in the development, onset and/or propagation of schizophrenia. Serotonin 171-180 dopamine beta-hydroxylase Homo sapiens 138-141 17968878-10 2007 Eliminating the 5-hydroxytryptamine-mediated component of this response with methysergide unveiled an enhanced PAR-2-mediated vasodilatation to compound 48/80 in PAR-2(+/+) mice and ablated the vasoconstrictor response in PAR-2(-/-) mice. Serotonin 16-35 coagulation factor II (thrombin) receptor-like 1 Mus musculus 111-116 28213524-0 2017 G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. Serotonin 54-63 G protein-coupled receptor kinase 2 Caenorhabditis elegans 0-35 17968878-10 2007 Eliminating the 5-hydroxytryptamine-mediated component of this response with methysergide unveiled an enhanced PAR-2-mediated vasodilatation to compound 48/80 in PAR-2(+/+) mice and ablated the vasoconstrictor response in PAR-2(-/-) mice. Serotonin 16-35 coagulation factor II (thrombin) receptor-like 1 Mus musculus 162-167 17968878-10 2007 Eliminating the 5-hydroxytryptamine-mediated component of this response with methysergide unveiled an enhanced PAR-2-mediated vasodilatation to compound 48/80 in PAR-2(+/+) mice and ablated the vasoconstrictor response in PAR-2(-/-) mice. Serotonin 16-35 coagulation factor II (thrombin) receptor-like 1 Mus musculus 162-167 17928982-6 2007 The increased consumption of serotonin and its precursor tryptophan due to IDO activation may explain the reduced availability of serotonin in depression. Serotonin 130-139 indoleamine 2,3-dioxygenase 1 Homo sapiens 75-78 15990280-3 2005 Preclinical studies in rats and mice have suggested that NK-1-RA do increase the neuronal release of serotonin (5-HT). Serotonin 101-110 tachykinin receptor 1 Homo sapiens 57-61 28213524-0 2017 G protein-coupled receptor kinase-2 (GRK-2) regulates serotonin metabolism through the monoamine oxidase AMX-2 in Caenorhabditis elegans. Serotonin 54-63 G protein-coupled receptor kinase 2 Caenorhabditis elegans 37-42 16314763-0 2005 Serotonin receptor genes HTR3A and HTR3B are not involved in Gilles de la Tourette syndrome. Serotonin 0-9 5-hydroxytryptamine receptor 3B Homo sapiens 35-40 28213524-3 2017 To further elucidate the role of GRKs in regulating GPCR-mediated behaviors, we utilized the genetic model system Caenorhabditis elegans Our studies demonstrate that grk-2 loss-of-function strains are egg laying-defective and contain low levels of serotonin (5-HT) and high levels of the 5-HT metabolite 5-hydroxyindole acetic acid (5-HIAA). Serotonin 248-257 G protein-coupled receptor kinase 2 Caenorhabditis elegans 166-171 28113063-4 2017 Here, we show that 5-hydoxytryptophan (5-HTP), the first product of an alternative branch of Trp degradation and a serotonin precursor, is essential to protect virus growth against IDO in cell culture. Serotonin 115-124 indoleamine 2,3-dioxygenase 1 Homo sapiens 181-184 16168406-6 2005 In lim-4 mutants, many aspects of ADF differentiation occur, however, they fail to express serotonin phenotype and exhibit aberrant cilia properties. Serotonin 91-100 LIM/homeobox protein lim-4 Caenorhabditis elegans 3-8 17567932-1 2007 OBJECTIVE: The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT(1A)]) receptors in cognition, behavior, and drug response is increasingly being recognized. Serotonin 33-42 5-hydroxytryptamine receptor 1A Homo sapiens 71-79 17567932-1 2007 OBJECTIVE: The important role of serotonin-1A (5-hydroxytryptamine-1A [5-HT(1A)]) receptors in cognition, behavior, and drug response is increasingly being recognized. Serotonin 47-66 5-hydroxytryptamine receptor 1A Homo sapiens 71-79 27686024-2 2017 The present study investigated the effect of serotonin 5-HT4 agents into the dorsal hippocampus (the CA1 region) on spatial and object novelty detection deficits induced by activation of cannabinoid CB1 receptors (CB1Rs) using arachidonylcyclopropylamide (ACPA) in a non-associative behavioral task designed to forecast the ability of rodents to encode spatial and non-spatial relationships between distinct stimuli. Serotonin 45-54 carbonic anhydrase 1 Mus musculus 101-104 17720915-5 2007 We show that exogenous serotonin and the antidepressant fluoxetine can attenuate DAF-16::GFP nuclear accumulation in WT animals exposed to hypergravity. Serotonin 23-32 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 81-87 16039851-2 2005 The template was N-substituted to give a series of compounds showing binding to human cloned 5-HT1A, 5-HT1B and 5-HT1D receptors with pKi"s greater than 9 and selectivities up to 1000-fold against other serotonin, dopamine and adrenergic receptors. Serotonin 203-212 5-hydroxytryptamine receptor 1A Homo sapiens 93-99 16433012-14 2005 These results highlight the link between a neurotransmitter (serotonin) and a neuropeptide (substance P). Serotonin 61-70 tachykinin 1 Mus musculus 92-103 28294055-6 2017 Selective inhibition of MAO-A results in the elevated level of serotonin and noradrenaline. Serotonin 63-72 monoamine oxidase A Homo sapiens 24-29 17763374-0 2007 1-cinnamyl-4-(2-methoxyphenyl)piperazines: synthesis, binding properties, and docking to dopamine (D(2)) and serotonin (5-HT(1A)) receptors. Serotonin 109-118 5-hydroxytryptamine receptor 1A Homo sapiens 120-127 27899892-5 2016 We found a statistically significant increase (nominal p < 0.05) in the expression of UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT2B7, and UGT2B17, as well as glucuronidation activities of serotonin, testosterone, and vorinostat during the first 25 years of life. Serotonin 191-200 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 105-111 17613938-4 2007 Serotonin (5-HT) seems to exert a protective role in the hippocampus and attenuates the behavioural consequences of stress by activating 5-HT1A receptors in this structure. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 137-143 27899892-5 2016 We found a statistically significant increase (nominal p < 0.05) in the expression of UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT2B7, and UGT2B17, as well as glucuronidation activities of serotonin, testosterone, and vorinostat during the first 25 years of life. Serotonin 191-200 UDP glucuronosyltransferase family 1 member A5 Homo sapiens 113-119 16079074-4 2005 CPF exposure on GD17-20 or PN1-4 evoked long-term increases in 5HT turnover across multiple regions; the effects were not secondary to changes in neurotransmitter content, which was unaffected or even decreased. Serotonin 63-66 serpin family E member 2 Rattus norvegicus 27-32 27642077-2 2016 Anxiolytic agents like selective serotonin re-uptake inhibitors (SSRIs) and neurokinin-1 receptor (NK1R) antagonists reduce amygdala activity and may attenuate serotonin formation according to animal studies. Serotonin 160-169 tachykinin receptor 1 Homo sapiens 76-97 17561096-2 2007 This study aimed to investigate the role of ROS in the mitogenic signaling activated during tyramine and serotonin oxidation by MAO-A in smooth muscle cells (SMC). Serotonin 105-114 monoamine oxidase A Homo sapiens 128-133 17561096-3 2007 Incubation of SMC with serotonin or tyramine induced intracellular ROS generation, and a signaling cascade involving metalloproteases and the neutral sphingomyelinase-2 (nSMase2, the initial step of the sphingolipid pathway), ERK1/2 phosphorylation, and DNA synthesis. Serotonin 23-32 sphingomyelin phosphodiesterase 3 Homo sapiens 142-168 17561096-3 2007 Incubation of SMC with serotonin or tyramine induced intracellular ROS generation, and a signaling cascade involving metalloproteases and the neutral sphingomyelinase-2 (nSMase2, the initial step of the sphingolipid pathway), ERK1/2 phosphorylation, and DNA synthesis. Serotonin 23-32 sphingomyelin phosphodiesterase 3 Homo sapiens 170-177 15791634-0 2005 Effects of serotonin 5-HT1A agonist in advanced Parkinson"s disease. Serotonin 11-20 5-hydroxytryptamine receptor 1A Homo sapiens 21-27 27642077-2 2016 Anxiolytic agents like selective serotonin re-uptake inhibitors (SSRIs) and neurokinin-1 receptor (NK1R) antagonists reduce amygdala activity and may attenuate serotonin formation according to animal studies. Serotonin 160-169 tachykinin receptor 1 Homo sapiens 99-103 15791634-3 2005 If 5-HT1A autoreceptors regulate dopamine as well as serotonin release, in parkinsonian patients inhibition of striatal serotonergic neuron firing might help maintain more physiological intrasynaptic dopamine concentrations and thus ameliorate motor fluctuations and dyskinesias. Serotonin 53-62 5-hydroxytryptamine receptor 1A Homo sapiens 3-9 27791021-0 2016 Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity. Serotonin 47-56 neurofibromin 1 Mus musculus 29-42 15739093-2 2005 The purpose of the present study was to investigate the effect of citalopram hydrobromide (a selective serotonin re-uptake inhibitor) on the 5-HT(2A) receptor and brain perfusion in impulsive-aggressive dogs by means of single-photon emission computed tomography. Serotonin 103-112 5-hydroxytryptamine receptor 2A Canis lupus familiaris 141-158 17499930-0 2007 Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux. Serotonin 33-42 prepronociceptin Rattus norvegicus 0-10 17499930-0 2007 Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux. Serotonin 33-42 prepronociceptin Rattus norvegicus 11-22 28404070-5 2016 Underlying mechanisms that could lead to irritable bowel syndrome include genetic factors (most notably an identified mutation of SCN5A); post-infectious changes, chronic infections and disturbances in the intestinal microbiota; low-grade mucosal inflammation, immune activation, and altered intestinal permeability; disordered bile salt metabolism (in 10-20% of cases with diarrhoea); abnormalities in serotonin metabolism; and alterations in brain function, which could be primary or secondary factors. Serotonin 403-412 sodium voltage-gated channel alpha subunit 5 Homo sapiens 130-135 17481962-9 2007 CONCLUSIONS: CD patients in remission who experience IBS-like symptoms have increased mucosal TpH-1 levels in the colon, suggesting that increased serotonin biosynthesis in the colon plays a role in the generation of the symptoms. Serotonin 147-156 tryptophan hydroxylase 1 Homo sapiens 94-99 17417058-1 2007 OBJECTIVE: Monoamine oxidase A is a mitochondrial enzyme involved in the degradation of certain neurotransmitter amines: serotonin and norepinephrine. Serotonin 121-130 monoamine oxidase A Homo sapiens 11-30 17725036-0 2007 [Migration and differentiation of neurons producing gonadotropin-releasing hormone under conditions of serotonin excess in the brain of mouse embryos]. Serotonin 103-112 gonadotropin releasing hormone 1 Mus musculus 52-82 17725036-2 2007 An immunocytochemical study has been performed of development of neurons producing gonadotropin-releasing hormone (GnRH) under conditions of excess of serotonin and noradrenaline in the mice in embryogenesis. Serotonin 151-160 gonadotropin releasing hormone 1 Mus musculus 83-113 17725036-2 2007 An immunocytochemical study has been performed of development of neurons producing gonadotropin-releasing hormone (GnRH) under conditions of excess of serotonin and noradrenaline in the mice in embryogenesis. Serotonin 151-160 gonadotropin releasing hormone 1 Mus musculus 115-119 17725036-5 2007 The percent of the GnRH-neurons in the Tg8 mouse embryos in caudal parts of the migration trajectory was lower than in rostral parts, the opposite distribution of the neurons being observed in the C3H line mouse embryos; at the excess of serotonin and noradrenaline in the Tg8 line mouse embryos, the total amount of GnRH-neurons in the brain was lower than in the C3H mice. Serotonin 238-247 gonadotropin releasing hormone 1 Mus musculus 19-23 17725036-6 2007 In males of the Tg8 line mice under conditions of excess of serotonin and noradrenaline the optical density of neurons, which correlated with the GnRH concentration in the cell, was higher than in control mice. Serotonin 60-69 gonadotropin releasing hormone 1 Mus musculus 146-150 17725036-7 2007 Thus, in the Tg8 mice under conditions of the serotonin and noradrenaline excess, migration of the GnRH-neurons to their final anlage in hypothalamus is accelerated as well as the total number of the GnRH-neurons decreases, which indicates a decrease of proliferation of cells-precursors and the earlier differentiation of neurons. Serotonin 46-55 gonadotropin releasing hormone 1 Mus musculus 99-103 17725036-7 2007 Thus, in the Tg8 mice under conditions of the serotonin and noradrenaline excess, migration of the GnRH-neurons to their final anlage in hypothalamus is accelerated as well as the total number of the GnRH-neurons decreases, which indicates a decrease of proliferation of cells-precursors and the earlier differentiation of neurons. Serotonin 46-55 gonadotropin releasing hormone 1 Mus musculus 200-204 17430116-2 2007 The synthesis of serotonin is dependent on the availability of tryptophan--an amino acid that is linked to the immune system by its catabolism via the enzyme indoleamine-2,3-dioxygenase (IDO). Serotonin 17-26 indoleamine 2,3-dioxygenase 1 Homo sapiens 158-185 17430116-2 2007 The synthesis of serotonin is dependent on the availability of tryptophan--an amino acid that is linked to the immune system by its catabolism via the enzyme indoleamine-2,3-dioxygenase (IDO). Serotonin 17-26 indoleamine 2,3-dioxygenase 1 Homo sapiens 187-190 17430117-10 2007 We here review the potential pathogenic links between chronic immune activation and decreased IDO mediated tryptophan and serotonin levels in morbid obesity. Serotonin 122-131 indoleamine 2,3-dioxygenase 1 Homo sapiens 94-97 17220354-0 2007 RGS4 modulates serotonin signaling in prefrontal cortex and links to serotonin dysfunction in a rat model of schizophrenia. Serotonin 15-24 regulator of G-protein signaling 4 Rattus norvegicus 0-4 17220354-8 2007 Thus, our study has revealed an important coupling of RGS4 to serotonin signaling in cortical neurons and provided a molecular and cellular mechanism underlying the potential involvement of RGS4 in the pathophysiology of schizophrenia. Serotonin 62-71 regulator of G-protein signaling 4 Rattus norvegicus 54-58 17301183-6 2007 Knockdown experiments of NGFI-A in hippocampal primary cell culture show that NGFI-A is required for serotonin-induced DNA demethylation and increased exon 1(7) GR promoter expression. Serotonin 101-110 early growth response 1 Homo sapiens 25-31 17301183-6 2007 Knockdown experiments of NGFI-A in hippocampal primary cell culture show that NGFI-A is required for serotonin-induced DNA demethylation and increased exon 1(7) GR promoter expression. Serotonin 101-110 early growth response 1 Homo sapiens 78-84 17188659-4 2007 In vitro data suggest that serotonin (5-hydroxytryptamine, 5-HT), via the 5-HT(2A) receptor (5-HT(2A)R) subtype, plays a key role in controlling the excitability of IHMNs. Serotonin 27-36 5-hydroxytryptamine receptor 2A Canis lupus familiaris 74-91 17188659-4 2007 In vitro data suggest that serotonin (5-hydroxytryptamine, 5-HT), via the 5-HT(2A) receptor (5-HT(2A)R) subtype, plays a key role in controlling the excitability of IHMNs. Serotonin 27-36 5-hydroxytryptamine receptor 2A Canis lupus familiaris 93-102 17188659-4 2007 In vitro data suggest that serotonin (5-hydroxytryptamine, 5-HT), via the 5-HT(2A) receptor (5-HT(2A)R) subtype, plays a key role in controlling the excitability of IHMNs. Serotonin 38-57 5-hydroxytryptamine receptor 2A Canis lupus familiaris 74-91 17188659-4 2007 In vitro data suggest that serotonin (5-hydroxytryptamine, 5-HT), via the 5-HT(2A) receptor (5-HT(2A)R) subtype, plays a key role in controlling the excitability of IHMNs. Serotonin 38-57 5-hydroxytryptamine receptor 2A Canis lupus familiaris 93-102 17241888-5 2007 Serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, TpH1 and TpH2, which are found, respectively, in EC cells and neurons. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 85-89 17198543-6 2007 Serotonin, which is a substrate for AANAT and a melatonin precursor, was also found in this region. Serotonin 0-9 aralkylamine N-acetyltransferase Rattus norvegicus 36-41 17097612-1 2006 Serotonin (5-hydroxytryptamine; 5-HT) 2A receptors contribute to the effects of 5-HT on platelet aggregation and vascular smooth muscle cell proliferation, and are reportedly involved in decreases in plasma levels of adiponectin, an adipokine, in diabetic subjects. Serotonin 0-9 adiponectin, C1Q and collagen domain containing Mus musculus 217-228 17097612-1 2006 Serotonin (5-hydroxytryptamine; 5-HT) 2A receptors contribute to the effects of 5-HT on platelet aggregation and vascular smooth muscle cell proliferation, and are reportedly involved in decreases in plasma levels of adiponectin, an adipokine, in diabetic subjects. Serotonin 11-30 adiponectin, C1Q and collagen domain containing Mus musculus 217-228 16940330-8 2006 Similar to activation of Epac1, stimulation of cells with serotonin to induce cAMP production resulted in Rap1 activation, increased cell adhesion and polarization, and enhanced chemotaxis. Serotonin 58-67 RAP1A, member of RAS oncogene family Homo sapiens 106-110 17010132-1 2006 BACKGROUND: It is widely accepted that, in addition to removing acetaldehyde produced during the metabolism of ethanol, mitochondrial aldehyde dehydrogenase (ALDH2) functions in the pathway by which aldehyde metabolites of the monoamines dopamine (DA) and serotonin (5-HT) are converted to their acidic metabolites. Serotonin 256-265 aldehyde dehydrogenase 2, mitochondrial Mus musculus 158-163 17010132-1 2006 BACKGROUND: It is widely accepted that, in addition to removing acetaldehyde produced during the metabolism of ethanol, mitochondrial aldehyde dehydrogenase (ALDH2) functions in the pathway by which aldehyde metabolites of the monoamines dopamine (DA) and serotonin (5-HT) are converted to their acidic metabolites. Serotonin 267-271 aldehyde dehydrogenase 2, mitochondrial Mus musculus 158-163 16889758-2 2006 In this study, we demonstrated that XBP-1 splicing is promptly induced in the rat brain including the hippocampus by both inescapable electric foot shock (IS) and pharmacologically manipulated activation of 5-hydroxytryptamine release in a dose-dependent manner. Serotonin 209-226 X-box binding protein 1 Rattus norvegicus 36-41 15822093-5 2005 When DTRH uses tryptophan as a substrate, substrate inhibition, catecholamine inhibition, and decreased tryptophan hydroxylase activity in the presence of serotonin synthesis inhibitors are observed. Serotonin 155-164 Tryptophan hydroxylase Drosophila melanogaster 5-9 15822093-5 2005 When DTRH uses tryptophan as a substrate, substrate inhibition, catecholamine inhibition, and decreased tryptophan hydroxylase activity in the presence of serotonin synthesis inhibitors are observed. Serotonin 155-164 Tryptophan hydroxylase Drosophila melanogaster 104-126 15822093-6 2005 When DTRH uses phenylalanine as a substrate, end product inhibition, increased phenylalanine hydroxylase activity after phosphorylation by cAMP-dependent protein kinase, and a decrease in phenylalanine hydroxylase activity in the presence of the serotonin synthesis inhibitor, alpha-methyl-(DL)-tryptophan are observed. Serotonin 246-255 Tryptophan hydroxylase Drosophila melanogaster 5-9 15822093-6 2005 When DTRH uses phenylalanine as a substrate, end product inhibition, increased phenylalanine hydroxylase activity after phosphorylation by cAMP-dependent protein kinase, and a decrease in phenylalanine hydroxylase activity in the presence of the serotonin synthesis inhibitor, alpha-methyl-(DL)-tryptophan are observed. Serotonin 246-255 Henna Drosophila melanogaster 188-213 15822093-7 2005 These experiments suggest that the presence of distinct tryptophan hydroxylase enzymes may be evolutionarily conserved and serve as an ancient mechanism to appropriately regulate the production of serotonin in its target tissues. Serotonin 197-206 Tryptophan hydroxylase Drosophila melanogaster 56-78 15891069-3 2005 By means of double immunofluorescence applied to sections of the monkey GIT, we demonstrated that, in the stomach, PrP(c) immunostaining occurs in subsets of histamine, somatostatin (Som), ghrelin (Ghr), gastrin (G), and serotonin (5HT) cells. Serotonin 221-230 major prion protein Macaca fascicularis 115-118 15891069-3 2005 By means of double immunofluorescence applied to sections of the monkey GIT, we demonstrated that, in the stomach, PrP(c) immunostaining occurs in subsets of histamine, somatostatin (Som), ghrelin (Ghr), gastrin (G), and serotonin (5HT) cells. Serotonin 232-235 major prion protein Macaca fascicularis 115-118 15736059-12 2005 Galanin and serotonin, on the other hand, increased the expression of EGF. Serotonin 12-21 epidermal growth factor Homo sapiens 70-73 15623815-4 2005 In contrast, both vascular tissues and trophoblasts showed decreased expressions for CRLR and RAMP1 proteins and declined CGRP binding sites in preeclamptic placentas; and 3) CGRP produced a dose-dependent relaxation of serotonin-induced contraction of umbilical and chorionic arteries from normal pregnancies, but the response to CGRP was significantly attenuated in the vessels from preeclampsia. Serotonin 220-229 receptor activity modifying protein 1 Homo sapiens 94-99 15672416-1 2005 To study the neurochemical and behavioral effects of altered brain-derived neurotrophic factor (BDNF) expression on a brain serotonin system with diminished serotonin transport capability, a double-mutant mouse model was developed by interbreeding serotonin transporter (SERT) knockout mice with BDNF heterozygous knockout mice (BDNF +/-), producing SERT -/- x BDNF +/- (sb) mice. Serotonin 124-133 brain derived neurotrophic factor Mus musculus 96-100 15672416-8 2005 These findings support the hypothesis that genetic changes in BDNF expression interact with serotonin and other circuits that modulate anxiety and stress-related behaviors. Serotonin 92-101 brain derived neurotrophic factor Mus musculus 62-66 27567324-1 2016 The serotonin neurotransmitter system is modulated in part by the uptake of synaptically released serotonin (5-HT) by the serotonin transporter (5-HTT), and by specific serotonin autoreceptors such as the somatodendritic 5-HT1A receptor, which can limit serotonin neuron depolarization. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 221-236 15734726-9 2005 Other genes of the endogenous opioid and monoaminergic systems, particularly genes encoding dopamine beta-hydroxylase, and the dopamine, serotonin, and norepinephrine transporters have also been implicated. Serotonin 137-146 dopamine beta-hydroxylase Homo sapiens 92-117 27567324-1 2016 The serotonin neurotransmitter system is modulated in part by the uptake of synaptically released serotonin (5-HT) by the serotonin transporter (5-HTT), and by specific serotonin autoreceptors such as the somatodendritic 5-HT1A receptor, which can limit serotonin neuron depolarization. Serotonin 98-107 5-hydroxytryptamine receptor 1A Homo sapiens 221-236 27567324-1 2016 The serotonin neurotransmitter system is modulated in part by the uptake of synaptically released serotonin (5-HT) by the serotonin transporter (5-HTT), and by specific serotonin autoreceptors such as the somatodendritic 5-HT1A receptor, which can limit serotonin neuron depolarization. Serotonin 98-107 5-hydroxytryptamine receptor 1A Homo sapiens 221-236 17003259-0 2006 Serotonin stimulates GnRH secretion through the c-Src-PLC gamma1 pathway in GT1-7 hypothalamic cells. Serotonin 0-9 gonadotropin releasing hormone 1 Mus musculus 21-25 27567324-1 2016 The serotonin neurotransmitter system is modulated in part by the uptake of synaptically released serotonin (5-HT) by the serotonin transporter (5-HTT), and by specific serotonin autoreceptors such as the somatodendritic 5-HT1A receptor, which can limit serotonin neuron depolarization. Serotonin 98-107 5-hydroxytryptamine receptor 1A Homo sapiens 221-236 17003259-0 2006 Serotonin stimulates GnRH secretion through the c-Src-PLC gamma1 pathway in GT1-7 hypothalamic cells. Serotonin 0-9 Rous sarcoma oncogene Mus musculus 50-53 15669056-10 2005 Some long projection neurons such as the pyramidal, mitral, principal neurons of several cranial nuclei, and presumably monoaminergic cells containing noradrenalin, dopamine, and serotonin, expressed high levels of L1cam. Serotonin 179-188 L1 cell adhesion molecule Mus musculus 215-220 27567324-7 2016 The lack of correlation between 5-HT1A and 5-HTT binding observed in the current study may be due to the different temporal responsiveness of regulatory processes controlling the somatodendritic 5-HT1A receptor and 5-HTT in response to changing availability of intrasynaptic serotonin. Serotonin 275-284 5-hydroxytryptamine receptor 1A Homo sapiens 195-210 17003259-3 2006 In this study, we report that serotonin activates phospholipase C (PLC) gamma1 in an Src-dependent manner in hypothalamic GT1-7 cells, and that pretreatment with either 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazole [3, 4-d] pyrimidine, an Src-kinase inhibitor, or U73122, a PLC inhibitor, attenuates the serotonin-induced increase in calcium levels. Serotonin 30-39 Rous sarcoma oncogene Mus musculus 85-88 17003259-3 2006 In this study, we report that serotonin activates phospholipase C (PLC) gamma1 in an Src-dependent manner in hypothalamic GT1-7 cells, and that pretreatment with either 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazole [3, 4-d] pyrimidine, an Src-kinase inhibitor, or U73122, a PLC inhibitor, attenuates the serotonin-induced increase in calcium levels. Serotonin 30-39 Rous sarcoma oncogene Mus musculus 241-244 17003259-4 2006 Also, PLC gamma1 binds to c-Src through the Src-homology (SH) 223 domain upon serotonin treatment. Serotonin 78-87 Rous sarcoma oncogene Mus musculus 28-31 17003259-4 2006 Also, PLC gamma1 binds to c-Src through the Src-homology (SH) 223 domain upon serotonin treatment. Serotonin 78-87 Rous sarcoma oncogene Mus musculus 44-47 15813642-8 2005 Furthermore, antagonism or genetic inactivation of the NK1R causes alterations in serotonin and norepinephrine neuronal transmission that are likely to contribute to the antidepressant/anxiolytic activity of NK1R antagonists but that are--at least partially--distinct from those produced by established antidepressant drugs. Serotonin 82-91 tachykinin receptor 1 Homo sapiens 208-212 27207911-9 2016 Furthermore, the usage of brain derived neurotrophic factor signaling cascade inhibitors, K252a and anti-brain derived neurotrophic factor antibody, each abolished the antidepressant-like effects of monosialotetrahexosylganglioside, while the usage of a serotonin system inhibitor did not. Serotonin 254-263 brain derived neurotrophic factor Mus musculus 26-59 15893820-3 2005 Recent research indicates that (a) uncontrollable stressors sensitize serotonergic neurons in the dorsal raphe, and that a corticotropin-releasing factor-related ligand, acting at the Type II receptor, is essential to this sensitization process, and (b) the consequent exaggerated release of serotonin in response to subsequent input is at least in part responsible for the behavioral changes that occur. Serotonin 292-301 corticotropin releasing hormone Homo sapiens 123-153 15664701-4 2005 Using dual-label immunocytochemistry for ER-alpha or ER-beta with tryptophan hydroxylase (TPH), the rate-limiting enzyme for 5-hydroxytryptamine (5-HT) synthesis, over 90% of ER-beta ir cells exhibited TPH-ir in all DRN subdivisions, whereas only 23% of ER-alpha ir cells contained TPH. Serotonin 125-144 estrogen receptor 1 (alpha) Mus musculus 41-49 17003259-6 2006 Furthermore, the inhibition of the activities of either PLC or Src results in a significant diminution of the serotonin-induced release of gonadotropin-releasing hormone (GnRH). Serotonin 110-119 Rous sarcoma oncogene Mus musculus 63-66 17003259-6 2006 Furthermore, the inhibition of the activities of either PLC or Src results in a significant diminution of the serotonin-induced release of gonadotropin-releasing hormone (GnRH). Serotonin 110-119 gonadotropin releasing hormone 1 Mus musculus 139-169 17003259-6 2006 Furthermore, the inhibition of the activities of either PLC or Src results in a significant diminution of the serotonin-induced release of gonadotropin-releasing hormone (GnRH). Serotonin 110-119 gonadotropin releasing hormone 1 Mus musculus 171-175 17003259-8 2006 Taken together, our findings demonstrate that serotonin stimulates the release of GnRH through the Src-PLC gamma1 pathway, via the modulation of intracellular calcium levels. Serotonin 46-55 gonadotropin releasing hormone 1 Mus musculus 82-86 17003259-8 2006 Taken together, our findings demonstrate that serotonin stimulates the release of GnRH through the Src-PLC gamma1 pathway, via the modulation of intracellular calcium levels. Serotonin 46-55 Rous sarcoma oncogene Mus musculus 99-102 27207911-9 2016 Furthermore, the usage of brain derived neurotrophic factor signaling cascade inhibitors, K252a and anti-brain derived neurotrophic factor antibody, each abolished the antidepressant-like effects of monosialotetrahexosylganglioside, while the usage of a serotonin system inhibitor did not. Serotonin 254-263 brain derived neurotrophic factor Mus musculus 105-138 15447813-1 2004 Antidepressants, such as serotonin or noradrenaline reuptake inhibitors (e.g. fluoxetine, nefadozone) or 5-HT1A agonists (flibanserin), desensitize the 5-HT1A autoreceptor, which may contribute to their clinical efficacy. Serotonin 25-34 5-hydroxytryptamine receptor 1A Homo sapiens 152-158 27328460-0 2016 Serotonin excites hippocampal CA1 GABAergic interneurons at the stratum radiatum-stratum lacunosum moleculare border. Serotonin 0-9 carbonic anhydrase 1 Mus musculus 30-33 15572344-8 2004 Carbon-fiber amperometry was used to assay quantal exocytosis of serotonin (5-HT) from insulin-containing granules following preincubation of INS-1 cells with 5-HT and a precursor. Serotonin 65-74 insulin 1 Rattus norvegicus 142-147 16395308-1 2006 Serotonin 1A (5-HT1A) binding potential (BP) as assessed by positron emission tomography (PET) is higher in major depressive disorder (MDD) in association with the higher expressing GG genotype of the 5-HT1A C-1019G polymorphism. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 14-20 16395308-1 2006 Serotonin 1A (5-HT1A) binding potential (BP) as assessed by positron emission tomography (PET) is higher in major depressive disorder (MDD) in association with the higher expressing GG genotype of the 5-HT1A C-1019G polymorphism. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 201-207 27328460-8 2016 These results indicate that serotonin interneurons expressing 5-HT2A Rs are localized primarily along the SR-SLM border of the CA1 region and represent a newly identified target for serotonin regulation in the hippocampus. Serotonin 28-37 carbonic anhydrase 1 Mus musculus 127-130 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Serotonin 147-156 monoamine oxidase A Homo sapiens 0-19 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Serotonin 37-46 monoamine oxidase A Homo sapiens 0-19 16829576-1 2006 Monoamine oxidase A (MAO A) degrades serotonin, norepinephrine, and dopamine and produces reactive oxygen that may cause neuronal cell death. Serotonin 37-46 monoamine oxidase A Homo sapiens 21-26 15534042-1 2004 The serotonin system is implicated in major depression and suicide and is negatively regulated by somatodendritic 5-HT1A autoreceptors. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 114-120 26227907-1 2016 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the metabolism of several biological amines such as dopamine, norepinephrine, and serotonin, which are important neurochemicals in the pathogenesis of major psychiatric illnesses. Serotonin 147-156 monoamine oxidase A Homo sapiens 21-25 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Serotonin 204-213 monoamine oxidase A Homo sapiens 0-19 15564894-1 2004 Monoamine oxidase A (MAOA) has been suggested to be involved in human behaviour and physiology due to its key role in the metabolism of several different biological amines including the neurotransmitters serotonin, norepinephrin and dopamine.Recently, a 30 bp repeat in the MAOA gene promoter (uMAOA) has been demonstrated to be polymorphic and to affect transcriptional activity. Serotonin 204-213 monoamine oxidase A Homo sapiens 21-25 26935476-7 2016 CONCLUSION: A maternal vitamin B6 -deficient diet affects the expression of genes related to GABA, glutamate, and serotonin metabolisms in offspring by regulating Gad1, Glul, Gls, and Tph1 mRNA expression. Serotonin 114-123 glutaminase Rattus norvegicus 175-178 15541318-0 2004 ApTrkl, a Trk-like receptor, mediates serotonin- dependent ERK activation and long-term facilitation in Aplysia sensory neurons. Serotonin 38-47 EPH receptor B2 Homo sapiens 59-62 16603234-4 2006 Moreover, the relationship between ERbeta and serotonin may be critical for the regulation of this behavior by estradiol. Serotonin 46-55 estrogen receptor 2 Rattus norvegicus 35-41 16861147-12 2006 Thus, progressive degeneration of 5-HT neurons affecting motoneuron activity constitutes the prime mover of the disease and its progression and treatment of ALS needs to be focused primarily on boosting 5-HT functions (e.g., pharmacologically via its precursors, reuptake inhibitors, selective 5-HT1A receptor agonists/5-HT2 receptor antagonists, and electrically through transcranial administration of AC pulsed picotesla electromagnetic fields) to prevent excessive glutamate activity in the motoneurons. Serotonin 34-38 5-hydroxytryptamine receptor 1A Homo sapiens 294-309 15541318-4 2004 Serotonin, the facilitatory neurotransmitter, activates ApTrkl, which, in turn, leads to activation of ERK. Serotonin 0-9 EPH receptor B2 Homo sapiens 103-106 15541318-5 2004 Finally, inhibiting the activation of ApTrkl with the Trk inhibitor K252a or using dsRNA to inhibit ApTrkl blocks the serotonin-mediated activation of ERK in the cell body, as well as the cell-wide long-term facilitation induced by 5-HT application to the cell body. Serotonin 118-127 EPH receptor B2 Homo sapiens 151-154 27211987-0 2016 alpha-Synuclein induced toxicity in brain stem serotonin neurons mediated by an AAV vector driven by the tryptophan hydroxylase promoter. Serotonin 47-56 synuclein alpha Homo sapiens 0-15 15138763-10 2004 The ALC treatment increased NA levels in the CC and the 5HIAA/5HT ratio in both CC and MFC. Serotonin 62-65 allantoicase Homo sapiens 4-7 27211987-1 2016 We studied the impact of alpha-synuclein overexpression in brainstem serotonin neurons using a novel vector construct where the expression of human wildtype alpha-synuclein is driven by the tryptophan hydroxylase promoter, allowing expression of alpha-synuclein at elevated levels, and with high selectivity, in serotonergic neurons. Serotonin 69-78 synuclein alpha Homo sapiens 25-40 16723097-5 2006 The K(m) value of serotonin to MAO-A was 1.66 micromol/L, while that of benzylamine to MAO-B was 0.80 micromol/L. Serotonin 18-27 monoamine oxidase A Homo sapiens 31-36 27163811-2 2016 OBJECTIVE: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Serotonin 31-35 microtubule associated protein tau Homo sapiens 171-174 16408289-5 2006 RT-PCR on the human osteoclasts demonstrated several serotonin receptors, the serotonin transporter, and the rate-limiting enzyme in serotonin synthesis, tryptophan hydroxylase 1 (Tph1). Serotonin 53-62 tryptophan hydroxylase 1 Homo sapiens 180-184 16408289-12 2006 Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF-kappaB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast-induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect. Serotonin 0-9 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 56-94 16408289-12 2006 Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF-kappaB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast-induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect. Serotonin 0-9 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 96-101 15496296-0 2004 Endogenously released 5-hydroxytryptamine depresses the spinal monosynaptic reflex via 5-HT1D receptors. Serotonin 22-41 5-hydroxytryptamine receptor 1D Rattus norvegicus 87-93 27163811-2 2016 OBJECTIVE: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Serotonin 31-35 microtubule associated protein tau Homo sapiens 178-181 27163811-2 2016 OBJECTIVE: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Serotonin 31-35 microtubule associated protein tau Homo sapiens 178-181 15480914-4 2004 Deficiencies in DTPH could affect the production of dopamine and serotonin, and thus dopaminergic and serotonergic signaling pathways. Serotonin 65-74 Henna Drosophila melanogaster 16-20 27163811-2 2016 OBJECTIVE: We aimed to measure 5-HT level in platelets in AD and explore its association with cerebrospinal fluid (CSF), AD biomarkers (amyloid-beta 1-42 (Abeta42), total tau (t-tau), and phosphorylated tau (p-tau)), and clinical symptoms. Serotonin 31-35 microtubule associated protein tau Homo sapiens 178-181 16275016-2 2006 Binding of the radioligand [18F]MPPF to 5HT1A receptors is sensitive to levels of endogenous serotonin. Serotonin 93-102 5-hydroxytryptamine receptor 1A Homo sapiens 40-45 27163811-6 2016 SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/Abeta42 ratio (p = 0.001), compared to those with high 5-HT levels. Serotonin 24-28 microtubule associated protein tau Homo sapiens 72-75 16503648-4 2006 Consequently, after validation of the docking procedure, we performed computational docking of melatonin and serotonin to structural models of the ferric and compound I and II (co I and co II, respectively) states of HRP and MPO. Serotonin 109-118 mitochondrially encoded cytochrome c oxidase I Homo sapiens 177-181 15340966-1 2004 In this work, a sub-minute and sensitive capillary electrophoresis with laser-induced fluorescence (CE-LIF) method was developed for the analysis and quantitation of the neurotransmitter 5-hydroxytryptamine (5-HT) or serotonin in urine. Serotonin 187-206 LIF interleukin 6 family cytokine Homo sapiens 103-106 27163811-6 2016 SCI patients with lower 5-HT level have higher AD CSF biomarkers, total tau (p = 0.026) and tau/Abeta42 ratio (p = 0.001), compared to those with high 5-HT levels. Serotonin 24-28 microtubule associated protein tau Homo sapiens 92-95 15340966-1 2004 In this work, a sub-minute and sensitive capillary electrophoresis with laser-induced fluorescence (CE-LIF) method was developed for the analysis and quantitation of the neurotransmitter 5-hydroxytryptamine (5-HT) or serotonin in urine. Serotonin 208-212 LIF interleukin 6 family cytokine Homo sapiens 103-106 15340966-1 2004 In this work, a sub-minute and sensitive capillary electrophoresis with laser-induced fluorescence (CE-LIF) method was developed for the analysis and quantitation of the neurotransmitter 5-hydroxytryptamine (5-HT) or serotonin in urine. Serotonin 217-226 LIF interleukin 6 family cytokine Homo sapiens 103-106 26876117-0 2016 Dopamine D2 and serotonin 5-HT1A receptor interaction in the context of the effects of antipsychotics - in vitro studies. Serotonin 16-25 5-hydroxytryptamine receptor 1A Homo sapiens 26-32 26373539-6 2016 In contrast, dopamine (DA)- and serotonin (5HT)-induced S(35)-GTPgammaS binding to Galphas/olf and Galphaq/11 were significantly increased in schizophrenia cases, while these parameters were strikingly reduced by in vitro treatment with antipsychotics. Serotonin 32-41 G protein subunit alpha q Homo sapiens 99-106 15262269-1 2004 Transgenic mice expressing both mutant amyloid precursor protein (APPswe) and presenilin-1 (PS1DeltaE9) develop amyloid deposits as early as 4 months of age and preliminary evidence suggests that this may be associated with degenerative changes in serotonin axons innervating the dentate gyrus of the hippocampus. Serotonin 248-257 presenilin 1 Mus musculus 78-90 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Serotonin 81-90 monoamine oxidase A Homo sapiens 4-23 16202396-2 2006 The monoamine oxidase-A (MAO-A) gene, coding for an enzyme primarily involved in serotonin and noradrenaline catabolism, presents a well-characterized functional polymorphism consisting of a variable number of tandem repeats in the promoter region, with high-activity and low-activity variants. Serotonin 81-90 monoamine oxidase A Homo sapiens 25-30 16195541-0 2006 Serotonin-induced growth of pulmonary artery smooth muscle requires activation of phosphatidylinositol 3-kinase/serine-threonine protein kinase B/mammalian target of rapamycin/p70 ribosomal S6 kinase 1. Serotonin 0-9 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 82-111 15262269-2 2004 In the present investigation, which focused on further delineating the effects of amyloid deposition on hippocampal neurochemistry, decreases in serotonin neurotransmitter levels (-25%) were discovered to be present at 18 months in APP+/PS1+ mice, while norepinephrine was reduced in the hippocampus of 12- (-30%) and 18-month-old (-45%) APP+/PS1+ double mutants. Serotonin 145-154 presenilin 1 Mus musculus 237-240 15262269-2 2004 In the present investigation, which focused on further delineating the effects of amyloid deposition on hippocampal neurochemistry, decreases in serotonin neurotransmitter levels (-25%) were discovered to be present at 18 months in APP+/PS1+ mice, while norepinephrine was reduced in the hippocampus of 12- (-30%) and 18-month-old (-45%) APP+/PS1+ double mutants. Serotonin 145-154 presenilin 1 Mus musculus 343-346 15262269-5 2004 Furthermore, in a different model of serotonergic and noradrenergic degeneration, BDNF protein levels were similarly increased in response to depletions in hippocampal serotonin and norepinephrine caused by the chemical neurotoxin 1-methyl-4-(2"-aminophenyl)-1,2,3,6-tetrahydropyridine (2"-NH2-MPTP). Serotonin 168-177 brain derived neurotrophic factor Mus musculus 82-86 26373539-6 2016 In contrast, dopamine (DA)- and serotonin (5HT)-induced S(35)-GTPgammaS binding to Galphas/olf and Galphaq/11 were significantly increased in schizophrenia cases, while these parameters were strikingly reduced by in vitro treatment with antipsychotics. Serotonin 43-46 G protein subunit alpha q Homo sapiens 99-106 26901633-5 2016 To this aim, serotonin synthesis was evaluated in vitro after treatment with GCs of either islets from CD1 mice or MIN6 cells, a beta-cell line. Serotonin 13-22 CD1 antigen complex Mus musculus 103-106 26634895-9 2016 Functional expression of B2R was confirmed by a transient disruptive action of BK on fictive locomotion generated by a combination of NMDA, 5-HT and dopamine. Serotonin 140-144 bradykinin receptor B2 Homo sapiens 25-28 15172095-1 2004 Episodic vagus nerve stimulation (VNS) induces phrenic long-term facilitation (LTF, a persistent augmentation of phrenic nerve activity after the stimulation ends), sensitive to the serotonin 5-HT(1,2,5,6,7) receptor antagonist methysergide and similar to that elicited by episodic hypoxia or carotid sinus nerve stimulation. Serotonin 182-191 lactotransferrin Rattus norvegicus 79-82 26474915-0 2016 5-Hydroxytryptamine promotes hepatocellular carcinoma proliferation by influencing beta-catenin. Serotonin 0-19 catenin beta 1 Homo sapiens 83-95 15251892-5 2004 Sequence variation within serotonin system genes, for example, a repeat polymorphism in the transcriptional control region of the monoamine oxidase gene (MAOA-LPR), increases the propensity for adolescent males to consume alcohol. Serotonin 26-35 monoamine oxidase A Homo sapiens 154-158 16475960-0 2006 Microdialysis approach to study serotonin outflow in mice following selective serotonin reuptake inhibitors and substance P (neurokinin 1) receptor antagonist administration: a review. Serotonin 32-41 tachykinin 1 Mus musculus 112-147 17094659-6 2006 NC could release histamine from both the mast cells and the neurons and it decreased CNS serotonin levels. Serotonin 89-98 prepronociceptin Rattus norvegicus 0-2 26654772-9 2016 A consequence of increased pro-inflammatory cytokines, is their induction of indoleamine 2,3-dioxygenase (IDO), which takes tryptophan away from serotonin, Nacetylserotonin and melatonin synthesis, driving it to the synthesis of neuroregulatory TRYCATs. Serotonin 145-154 indoleamine 2,3-dioxygenase 1 Homo sapiens 77-104 26654772-9 2016 A consequence of increased pro-inflammatory cytokines, is their induction of indoleamine 2,3-dioxygenase (IDO), which takes tryptophan away from serotonin, Nacetylserotonin and melatonin synthesis, driving it to the synthesis of neuroregulatory TRYCATs. Serotonin 145-154 indoleamine 2,3-dioxygenase 1 Homo sapiens 106-109 15088153-3 2004 One of the key enzymes in the degradation of serotonin and to a lesser extent of dopamine is monoamine oxidase A (MAO-A). Serotonin 45-54 monoamine oxidase A Homo sapiens 93-112 27478308-0 2016 Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon. Serotonin 0-9 matrix metallopeptidase 3 Mus musculus 73-78 17017970-8 2006 In these nuclei, 5-HT1A receptors function as somatodendritic autoreceptors controlling the release of serotonin in terminal areas. Serotonin 103-112 5-hydroxytryptamine receptor 1A Homo sapiens 17-23 26159182-1 2016 Acute estradiol treatment was reported to slow the clearance of serotonin via activation of estrogen receptors (ER)beta and/or GPR30 and to block the ability of a selective serotonin reuptake inhibitor (SSRI) to slow serotonin clearance via activation of ERalpha. Serotonin 64-73 estrogen receptor 2 Rattus norvegicus 112-119 16931444-5 2006 As tyrosine hydroxylase levels in the LC are regulated by serotonin and in a previous study we demonstrated that this neurotransmitter was increased in 2,4-D-exposed pups, an indirect effect through serotonergic inhibition could be involved in the decreased DbetaH synthesis in the LC of these pups. Serotonin 58-67 dopamine beta-hydroxylase Rattus norvegicus 258-264 15102340-7 2004 CONCLUSIONS: The present results suggest that the HTR3A and DBH genes may participate in the regulation of dopamine and serotonin turnover rates in the central nervous system. Serotonin 120-129 dopamine beta-hydroxylase Homo sapiens 60-63 26159182-1 2016 Acute estradiol treatment was reported to slow the clearance of serotonin via activation of estrogen receptors (ER)beta and/or GPR30 and to block the ability of a selective serotonin reuptake inhibitor (SSRI) to slow serotonin clearance via activation of ERalpha. Serotonin 64-73 G protein-coupled estrogen receptor 1 Rattus norvegicus 127-132 14751404-2 2004 The blockade of 5-HT(1A) autoreceptors occurring on administration of a selective serotonin reuptake inhibitor together with a 5-HT(1A) autoreceptor antagonist is responsible for the acute increase in 5-hydroxytryptamine (serotonin, 5-HT) levels observed under these circumstances. Serotonin 201-220 5-hydroxytryptamine receptor 1A Homo sapiens 16-23 14751404-2 2004 The blockade of 5-HT(1A) autoreceptors occurring on administration of a selective serotonin reuptake inhibitor together with a 5-HT(1A) autoreceptor antagonist is responsible for the acute increase in 5-hydroxytryptamine (serotonin, 5-HT) levels observed under these circumstances. Serotonin 201-220 5-hydroxytryptamine receptor 1A Homo sapiens 127-134 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Serotonin 117-126 monoamine oxidase A Homo sapiens 0-19 16139427-1 2005 Monoamine oxidase A (MAO-A) is an enzyme involved in the metabolism of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline in the brain. Serotonin 117-126 monoamine oxidase A Homo sapiens 21-26 14751404-2 2004 The blockade of 5-HT(1A) autoreceptors occurring on administration of a selective serotonin reuptake inhibitor together with a 5-HT(1A) autoreceptor antagonist is responsible for the acute increase in 5-hydroxytryptamine (serotonin, 5-HT) levels observed under these circumstances. Serotonin 82-91 5-hydroxytryptamine receptor 1A Homo sapiens 16-23 26677330-11 2015 CONCLUSION: These results demonstrate that serum levels of interleukin-6, interleukin-8, and macrophage inflammatory protein-1beta as potential blood biomarkers could be utilized to identify the responsiveness of patients to serotonin and norepinephrine reuptake inhibitor like milnacipran, or to identify those patients who may experience AEs strong enough to warrant discontinuation of treatment. Serotonin 225-234 C-C motif chemokine ligand 4 like 2 Homo sapiens 93-130 14991225-1 2004 RATIONALE: Central 5-hydroxytryptamine (5-HT) release is regulated by inhibitory 5-HT autoreceptors, including 5-HT(1A) and 5-HT(1B) receptors. Serotonin 19-38 5-hydroxytryptamine receptor 1A Cavia porcellus 111-118 26207892-2 2015 Selective serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A or 5-HT1B receptor agonists, and, very recently, the mixed 5-HT1A /5-HT1B receptor agonist, eltoprazine, proved effective in inhibiting L-dopa-induced dyskinesias in experimental animals and parkinsonian patients. Serotonin 10-19 5-hydroxytryptamine receptor 1A Homo sapiens 48-54 14719046-3 2004 In addition, the enzyme indoleamine 2,3-dioxygenase (IDO), which converts tryptophan into kynurenine, may play an important role, first, because IDO activation leads to reduced levels of tryptophan, the precursor of serotonin (5-HT), and thus to reduced central 5-HT synthesis. Serotonin 216-225 indoleamine 2,3-dioxygenase 1 Homo sapiens 53-56 14719046-3 2004 In addition, the enzyme indoleamine 2,3-dioxygenase (IDO), which converts tryptophan into kynurenine, may play an important role, first, because IDO activation leads to reduced levels of tryptophan, the precursor of serotonin (5-HT), and thus to reduced central 5-HT synthesis. Serotonin 216-225 indoleamine 2,3-dioxygenase 1 Homo sapiens 145-148 15489027-9 2004 In addition, we show that 5-HT(4) receptors remain functional in the presence of excess Abeta peptide and may therefore be a useful target in AD. Serotonin 26-30 amyloid beta (A4) precursor protein Mus musculus 88-93 14697878-6 2004 The presence of repeat units within the 2 kb human MAO A promoter which is associated with promoter activity and enzymatic activity in human fibroblast culture provided a tool to study human population with abnormal behaviors related to serotonin and other neurotransmitters. Serotonin 237-246 monoamine oxidase A Homo sapiens 51-56 14993070-7 2003 In the second study, responses of CA1 hippocampal neurons to serotonin were recorded with microelectrodes. Serotonin 61-70 carbonic anhydrase 1 Rattus norvegicus 34-37 14660743-8 2003 These results demonstrate that oral allergen-induced diarrhea associated with experimental Th2 intestinal inflammation is largely mast cell, IgE, serotonin, and PAF dependent. Serotonin 146-155 heart and neural crest derivatives expressed 2 Mus musculus 91-94 14671188-7 2003 The precursor of melatonin, serotonin was stepwise depleted during the course of AD, as indicated by the up-regulated monoamine oxidase A mRNA and activity (5-hydroxyindoleacetic acid:serotonin ratio). Serotonin 28-37 monoamine oxidase A Homo sapiens 118-137 14671188-7 2003 The precursor of melatonin, serotonin was stepwise depleted during the course of AD, as indicated by the up-regulated monoamine oxidase A mRNA and activity (5-hydroxyindoleacetic acid:serotonin ratio). Serotonin 184-193 monoamine oxidase A Homo sapiens 118-137 14671188-8 2003 We conclude that a dysfunction of noradrenergic regulation and the depletion of serotonin by increased monoamine oxidase A result in the loss of melatonin rhythm already in preclinical AD. Serotonin 80-89 monoamine oxidase A Homo sapiens 103-122 14651728-3 2003 We aimed to assess the MAO type A (MAO-A) involvement in the metabolic pathway of rizatriptan (RIZ), an antimigraine 5-hydroxytryptamine (5-HT)1B/1D agonist, and the interethnic difference in MAO activities between Caucasians and Japanese using RIZ as a model drug in in vitro experiments. Serotonin 117-136 monoamine oxidase A Homo sapiens 23-33 14651728-3 2003 We aimed to assess the MAO type A (MAO-A) involvement in the metabolic pathway of rizatriptan (RIZ), an antimigraine 5-hydroxytryptamine (5-HT)1B/1D agonist, and the interethnic difference in MAO activities between Caucasians and Japanese using RIZ as a model drug in in vitro experiments. Serotonin 117-136 monoamine oxidase A Homo sapiens 35-40 12898089-1 2003 Tetrodotoxin-resistant (TTX-R) sodium current in small-size dorsal root ganglia (DRG) neurons is upregulated by prostaglandin E(2) and serotonin through a protein kinase A (PKA)/protein kinase (PKC) pathway, suggesting G protein modulation of one or more TTX-R channels in these neurons. Serotonin 135-144 protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus 155-177 12969236-1 2003 This study evaluated the influence of monoamines, serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline, on differentiating gonadotropin-releasing hormone (GnRH)-producing neurones in foetal mice. Serotonin 82-86 gonadotropin releasing hormone 1 Mus musculus 126-156 14557952-3 2003 On stimulation of 5-HT1A autoreceptors, they regulate serotonin release in the distal regions of the neuron by inhibitory firing activity. Serotonin 54-63 5-hydroxytryptamine receptor 1A Homo sapiens 18-24 12784114-1 2003 Brain-derived neurotrophic factor (BDNF) affects the development of brain neurotransmitter systems, including dopamine and serotonin systems that are important for cocaine"s rewarding and locomotor stimulatory properties. Serotonin 123-132 brain derived neurotrophic factor Mus musculus 0-33 12784114-1 2003 Brain-derived neurotrophic factor (BDNF) affects the development of brain neurotransmitter systems, including dopamine and serotonin systems that are important for cocaine"s rewarding and locomotor stimulatory properties. Serotonin 123-132 brain derived neurotrophic factor Mus musculus 35-39 12784114-8 2003 These data confirm important roles for BDNF in psychostimulant actions, presumably via neurotrophic effects on dopamine and serotonin systems. Serotonin 124-133 brain derived neurotrophic factor Mus musculus 39-43 12738797-7 2003 Serotonin via phosphatidylinositol-3 kinase/Akt can activate NF-kappaB that is required for the regulation of the mitochondrial adenine nucleotide translocator (ANT-1). Serotonin 0-9 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Mus musculus 161-166 12716405-0 2003 Influence of serotonin on the development and migration of gonadotropin-releasing hormone neurones in rat foetuses. Serotonin 13-22 gonadotropin releasing hormone 1 Rattus norvegicus 59-89 12676650-13 2003 Conversely, nearly all cells expressing chromogranin A or substance P and approximately 50% of the cells expressing secretin or serotonin exhibited Kir 6.2 staining. Serotonin 128-137 potassium inwardly rectifying channel, subfamily J, member 11 Mus musculus 148-155 12629534-2 2003 Our objective in this study was to determine whether functional polymorphisms of the genes that encode for the serotonin transporter promoter (5HTTLPR) and monoamine oxidase A (MAOA-uVNTR) are associated with CNS serotonin turnover-indexed by cerebrospinal fluid levels of 5-hydroxyindoleacetic acid (5-HIAA)-in a community sample of healthy adults. Serotonin 111-120 monoamine oxidase A Homo sapiens 177-181 12574815-3 2003 Selective antagonists of both CB1 and CB2 cannabinoid receptors inhibited this binding, which was enhanced up to approximately 230% over the controls by 1 micro M serotonin (5-hydroxytryptamine, 5-HT). Serotonin 163-172 cannabinoid receptor 2 Homo sapiens 38-41 12574815-3 2003 Selective antagonists of both CB1 and CB2 cannabinoid receptors inhibited this binding, which was enhanced up to approximately 230% over the controls by 1 micro M serotonin (5-hydroxytryptamine, 5-HT). Serotonin 174-193 cannabinoid receptor 2 Homo sapiens 38-41 12574815-3 2003 Selective antagonists of both CB1 and CB2 cannabinoid receptors inhibited this binding, which was enhanced up to approximately 230% over the controls by 1 micro M serotonin (5-hydroxytryptamine, 5-HT). Serotonin 195-199 cannabinoid receptor 2 Homo sapiens 38-41 12574815-9 2003 Also, 1 micro M 5-HT enhanced the effect of 2-AG on inositol-1,4,5-trisphosphate ( approximately 500% of the controls), cyclic AMP ( approximately 20%) and [(3)H]2-AG release ( approximately 570%), and the latter process was shown to be partly ( approximately 50%) involved in the 5-HT-dependent platelet activation. Serotonin 16-20 H2A clustered histone 11 Homo sapiens 160-166 12522077-0 2003 Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex. Serotonin 84-103 prepronociceptin Rattus norvegicus 40-50 16180022-0 2005 The macaque inferior parietal lobule: cytoarchitecture and distribution pattern of serotonin 5-HT1A binding sites. Serotonin 83-92 5-hydroxytryptamine receptor 1A Homo sapiens 93-99 16005635-1 2005 Long-term potentiation in sympathetic ganglia (gLTP) is an activity-dependent unique form of synaptic plasticity in that it is serotonin-dependent and can be completely inhibited by 5-HT3 receptor antagonists. Serotonin 127-136 glycolipid transfer protein Rattus norvegicus 47-51 16219295-0 2005 5-Hydroxytryptamine augments migration of human aortic smooth muscle cells through activation of RhoA and ERK. Serotonin 0-19 EPH receptor B2 Homo sapiens 106-109 16309229-9 2005 Studies were also performed after incubating the PC3 cells with 5HT or 5HT(1B) agonists for a short duration, followed by the addition of doxazosin. Serotonin 64-67 proprotein convertase subtilisin/kexin type 1 Homo sapiens 49-52 16309229-12 2005 Furthermore, prior incubation of PC3 cells with 5HT or 5HT(1B) agonist increased cell viability as compared to treatment with doxazosin alone. Serotonin 48-51 proprotein convertase subtilisin/kexin type 1 Homo sapiens 33-36 15975715-2 2005 After 14 postnatal days, concentrations of biogenic amines were smaller in mecp2-null mice than those in control mice and at 42 postnatal days, norepinephrine, dopamine and serotonin concentrations in mecp2-null mice were significantly smaller by 25, 24 and 16%, respectively. Serotonin 173-182 methyl CpG binding protein 2 Mus musculus 201-206 16081104-8 2005 Finally, electrophysiological recording of the pharyngeal activity showed a high sensitivity of the nep-1 pharynx to serotonin (5-HT) and to the neuropeptide AF1 (C.elegans FLP-8), indicating that NEP-1 is a central component that controls the neuronal innervation of pharyngeal pumping in C.elegans. Serotonin 117-126 Neprilysin-1 Caenorhabditis elegans 100-105 16093733-2 2005 In addition, we administered serotonin antagonist (sarpogrelate hydrochloride) to type 2 diabetes patients who had increased soluble E-selectin levels. Serotonin 29-38 selectin E Homo sapiens 133-143 16126914-0 2005 Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1. Serotonin 0-9 solute carrier family 36 member 1 Homo sapiens 100-104 16126914-5 2005 When PAT1 was expressed in Xenopus laevis oocytes and analyzed by the two-electrode voltage clamp technique, glycine elicited high inward currents that were dependent on membrane potential but no currents were observed with l-tryptophan, tryptamine, 5-hydroxy-l-tryptophan, or serotonin. Serotonin 277-286 solute carrier family 36 member 1 Homo sapiens 5-9 16126914-7 2005 We conclude that serotonin, l-tryptophan, and tryptamine bind to PAT1 with potencies similar to the prototype substrates, inhibit transport function but are not transported by this carrier protein. Serotonin 17-26 solute carrier family 36 member 1 Homo sapiens 65-69 15956165-3 2005 Animal data and the high incidence of myoclonic seizures in serotonin-intoxicated patients suggest that the serotonin system may be disturbed in JME. Serotonin 60-69 myoclonic epilepsy, juvenile, 2 Homo sapiens 145-148 15956165-3 2005 Animal data and the high incidence of myoclonic seizures in serotonin-intoxicated patients suggest that the serotonin system may be disturbed in JME. Serotonin 108-117 myoclonic epilepsy, juvenile, 2 Homo sapiens 145-148 15956165-4 2005 OBJECTIVE: To test the hypothesis that JME is associated with a disturbed serotonin system and that this disturbance could be reflected in altered serotonin 1A receptor binding. Serotonin 74-83 myoclonic epilepsy, juvenile, 2 Homo sapiens 39-42 15893579-0 2005 A serotonin 5-HT1A receptor agonist prevents behavioral sensitization to L-DOPA in a rodent model of Parkinson"s disease. Serotonin 2-11 5-hydroxytryptamine receptor 1A Homo sapiens 12-27 15769739-5 2005 Siglec-5 could efficiently inhibit FcepsilonRI-mediated calcium fluxing and serotonin release after co-cross-linking. Serotonin 76-85 sialic acid binding Ig like lectin 5 Homo sapiens 0-8 15769739-6 2005 Surprisingly, a double tyrosine to alanine mutant of Siglec-5 could still mediate strong inhibition of serotonin release in the absence of detectable tyrosine phosphorylation, whereas a double tyrosine to phenylalanine mutant lost all inhibitory activity. Serotonin 103-112 sialic acid binding Ig like lectin 5 Homo sapiens 53-61 15836614-0 2005 Serotonin via 5-HT7 receptors activates p38 mitogen-activated protein kinase and protein kinase C epsilon resulting in interleukin-6 synthesis in human U373 MG astrocytoma cells. Serotonin 0-9 protein kinase C epsilon Homo sapiens 81-105 15634943-6 2005 Moreover, inhibition of gamma-GT with acivicin increases the concentration of GSH and N-acetylcysteine conjugates of N-methyl-alpha-MeDA in brain dialysate, and there is a direct correlation between the concentrations of metabolites in dialysate and the extent of neurotoxicity, measured by decreases in serotonin (5-HT) and 5-hydroxyindole acetic (5-HIAA) levels. Serotonin 304-313 gamma-glutamyltransferase 1 Rattus norvegicus 24-32 15758168-5 2005 In the PET group, we also studied the influence of a common variable number tandem repeat polymorphism [short (S) and long (L) alleles] of the 5-HT transporter (5-HTT) gene on 5-HT1A receptor density. Serotonin 143-147 5-hydroxytryptamine receptor 1A Homo sapiens 176-191 15825548-1 2005 BACKGROUND AND PURPOSE: Repinotan is a potent, serotonin (5-HT1A) full receptor agonist that interferes with ischemia-mediated neuronal cell death in animal models. Serotonin 47-56 5-hydroxytryptamine receptor 1A Homo sapiens 58-64 15787701-1 2005 The somatodendritic 5-HT(1A) autoreceptor has been considered a major determinant of the output of the serotonin (5-HT) neuronal system. Serotonin 103-112 5-hydroxytryptamine receptor 1A Homo sapiens 20-27 15680262-0 2005 The 5-HT1A receptor modulates the effects of cocaine on extracellular serotonin and dopamine levels in the nucleus accumbens. Serotonin 70-79 5-hydroxytryptamine receptor 1A Homo sapiens 4-19 15680262-1 2005 The regulation of extracellular levels of serotonin (5-HT) and dopamine in response to cocaine by 5-HT1A receptors was examined using in vivo microdialysis and the 5-HT1A receptor antagonist 4-(2"-methoxy-)-phenyl-1-[2"-(N-2""-pyridinyl)-p-fluorobenzamido-]ethyl-piperazine (p-MPPF). Serotonin 42-51 5-hydroxytryptamine receptor 1A Homo sapiens 98-104 15680262-1 2005 The regulation of extracellular levels of serotonin (5-HT) and dopamine in response to cocaine by 5-HT1A receptors was examined using in vivo microdialysis and the 5-HT1A receptor antagonist 4-(2"-methoxy-)-phenyl-1-[2"-(N-2""-pyridinyl)-p-fluorobenzamido-]ethyl-piperazine (p-MPPF). Serotonin 42-51 5-hydroxytryptamine receptor 1A Homo sapiens 98-113 15621007-1 2005 Serotonin (5-HT) can induce a release of intraglial S-100B and produce a change in glial morphology. Serotonin 0-9 S100 protein, beta polypeptide, neural Mus musculus 52-58 12522077-0 2003 Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex. Serotonin 84-103 prepronociceptin Rattus norvegicus 51-62 12522077-1 2003 1 The pharmacological profiles of presynaptic nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) modulating 5-hydroxytryptamine (5-HT) and noradrenaline (NE) release in the rat neocortex were characterized in a preparation of superfused synaptosomes challenged with 10 mM KCl. Serotonin 112-131 prepronociceptin Rattus norvegicus 46-56 12522077-1 2003 1 The pharmacological profiles of presynaptic nociceptin/orphanin FQ (N/OFQ) peptide receptors (NOP) modulating 5-hydroxytryptamine (5-HT) and noradrenaline (NE) release in the rat neocortex were characterized in a preparation of superfused synaptosomes challenged with 10 mM KCl. Serotonin 112-131 prepronociceptin Rattus norvegicus 57-68 12519858-0 2003 Luteinizing hormone (LH)-responsive Cushing"s syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro. Serotonin 191-200 luteinizing hormone/choriogonadotropin receptor Homo sapiens 77-88 26207892-2 2015 Selective serotonin (5-hydroxytryptamine; 5-HT) 5-HT1A or 5-HT1B receptor agonists, and, very recently, the mixed 5-HT1A /5-HT1B receptor agonist, eltoprazine, proved effective in inhibiting L-dopa-induced dyskinesias in experimental animals and parkinsonian patients. Serotonin 42-46 5-hydroxytryptamine receptor 1A Homo sapiens 48-54 12678665-8 2003 When added to the culture medium, specific serotonin 5-HT1D agonist sumatriptan (1 microM) significantly inhibited the development of mouse embryos cultured in vitro. Serotonin 43-52 5-hydroxytryptamine (serotonin) receptor 1D Mus musculus 53-59 26496594-1 2015 Flibanserin acts at cortical, limbic, hypothalamic, and brainstem nuclei to inhibit serotonin release by binding to 5-HT1A autoreceptors and block postsynaptic action of serotonin at 5-HT2A receptors. Serotonin 84-93 5-hydroxytryptamine receptor 1A Homo sapiens 116-122 14583800-1 2003 Alteration of monoaminergic neurotransmission has been implicated in the pathophysiology of mood disorders, and CYP2C9 enzyme activity has been shown to be modulated by serotonin in vitro. Serotonin 169-178 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 112-118 15813642-8 2005 Furthermore, antagonism or genetic inactivation of the NK1R causes alterations in serotonin and norepinephrine neuronal transmission that are likely to contribute to the antidepressant/anxiolytic activity of NK1R antagonists but that are--at least partially--distinct from those produced by established antidepressant drugs. Serotonin 82-91 tachykinin receptor 1 Homo sapiens 55-59 26412054-2 2015 The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain. Serotonin 33-42 5-hydroxytryptamine receptor 1A Homo sapiens 43-49 15448960-2 2005 The targetting of NK-1R neurons by serotoninergic (5-hydroxytryptamine, 5-HT) axons would provide a straightforward means to exert an inhibitory analgesic effect at spinal level. Serotonin 52-70 tachykinin receptor 1 Rattus norvegicus 18-23 12486159-7 2002 An analysis of the promoter region of the ASIC3 encoding gene, an ASIC specifically expressed in sensory neurons and associated with chest pain that accompanies cardiac ischemia, reveals that gene transcription is controlled by NGF and serotonin. Serotonin 236-245 acid sensing ion channel subunit 3 Homo sapiens 42-47 12486159-7 2002 An analysis of the promoter region of the ASIC3 encoding gene, an ASIC specifically expressed in sensory neurons and associated with chest pain that accompanies cardiac ischemia, reveals that gene transcription is controlled by NGF and serotonin. Serotonin 236-245 acid sensing ion channel subunit 1 Homo sapiens 42-46 26412054-2 2015 The drug has a high affinity for serotonin 5-HT1A and 5-HT2A receptors (5-HT1A agonist/5-HT2A antagonist) and is believed to treat HSDD by increasing levels of dopamine and noradrenaline and lowering levels of serotonin in the brain. Serotonin 33-42 5-hydroxytryptamine receptor 1A Homo sapiens 72-78 16251523-0 2005 Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). Serotonin 58-67 5-hydroxytryptamine receptor 2A Canis lupus familiaris 131-152 26370232-9 2015 Furthermore, we found that PP2-expressing cells contain serotonin and aanat2, the key enzyme involved in melatonin synthesis from serotonin, whereas PP1-expressing cells do not contain either, suggesting that blue-sensitive PP2 is instead involved in light-regulation of melatonin secretion. Serotonin 130-139 parapinopsin b Danio rerio 27-30 26370232-9 2015 Furthermore, we found that PP2-expressing cells contain serotonin and aanat2, the key enzyme involved in melatonin synthesis from serotonin, whereas PP1-expressing cells do not contain either, suggesting that blue-sensitive PP2 is instead involved in light-regulation of melatonin secretion. Serotonin 130-139 parapinopsin b Danio rerio 224-227 12472894-3 2002 In this study, we report that levels of ApC/EBP mRNA in the eye of Aplysia are modulated by serotonin or light. Serotonin 92-101 ApC/EBP Aplysia californica 40-47 12472894-4 2002 These responses of ApC/EBP to serotonin and light are mimicked by analogs of cAMP and cGMP. Serotonin 30-39 ApC/EBP Aplysia californica 19-26 26081758-5 2015 The pharmacology of these compounds is thus qualitatively different from the endogenous agonist serotonin, indicating functional selectivity of 5-HT1AR-mediated response pathways. Serotonin 96-105 5-hydroxytryptamine receptor 1A Homo sapiens 144-151 12502014-1 2002 Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). Serotonin 104-113 monoamine oxidase A Homo sapiens 0-19 15693702-5 2005 PAF was originally characterized by inducing aggregation and secretion of serotonin and histamine from rabbit platelets. Serotonin 74-83 PCNA clamp associated factor Homo sapiens 0-3 15677425-9 2004 That raised 5HT activity may mediate hippocampal 5HT(1A) receptor changes evoked by stress suggests a bidirectional role for 5HT in the development of PTSD. Serotonin 12-15 5-hydroxytryptamine receptor 1A Homo sapiens 49-65 12502014-1 2002 Monoamine oxidase A (MAOA) and tryptophan hydroxylase (TPH) are the staple enzymes in the metabolism of serotonin (5-HT). Serotonin 104-113 monoamine oxidase A Homo sapiens 21-25 26053941-0 2015 Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats. Serotonin 6-15 ATP binding cassette subfamily B member 4 Rattus norvegicus 62-66 12502025-0 2002 Interleukin 1alpha alters hippocampal serotonin and norepinephrine release during open-field behavior in Sprague-Dawley animals: differences from the Fawn-Hooded animal model of depression. Serotonin 38-47 interleukin 1 alpha Homo sapiens 0-18 15677436-3 2004 Previously, we found that rises in the corticosterone level, as after acute stressors, enhance the response of hippocampal CA1 neurons to serotonin (5-HT), which hyperpolarizes the membrane via the 5-HT1A receptor. Serotonin 138-147 carbonic anhydrase 1 Rattus norvegicus 123-126 26136513-10 2015 Finally, serotonin expression was attenuated in islets of beta-cell-specific Stat5-deficient mice compared with that of control littermates during pregnancy. Serotonin 9-18 signal transducer and activator of transcription 5A Mus musculus 77-82 15544576-3 2004 Since tryptophan hydroxylase (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, its role in the pathophysiology of these psychiatric diseases has been intensively studied. Serotonin 67-76 tryptophan hydroxylase 1 Homo sapiens 30-34 15569254-9 2004 Most importantly, ser-2 null mutants (pk1357) fail to suppress head movements while reversing in response to nose-touch, suggesting a role for SER-2 in the regulation of foraging behavior, and fail to respond to tyramine in assays measuring serotonin-dependent pharyngeal pumping. Serotonin 241-250 G_PROTEIN_RECEP_F1_2 domain-containing protein;Tyramine receptor Ser-2 Caenorhabditis elegans 18-23 12882365-8 2002 The most prominent neurochemical alterations in the forebrains of aged eNOS-/- mice were: (a) increased acetylcholine levels in the neostriatum; (b) decreased noradrenaline concentrations in the ventral striatum; and (c) lower serotonin levels in the frontal cortex and ventral striatum. Serotonin 227-236 nitric oxide synthase 3, endothelial cell Mus musculus 71-75 12112407-0 2002 Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 19-22 25818845-1 2015 Kiss1, a neuropeptide predominantly expressed in the habenula, modulates the serotonin (5-HT) system to decrease odorant cue [alarm substance (AS)]-evoked fear behaviour in the zebrafish. Serotonin 77-86 KiSS-1 metastasis suppressor Danio rerio 0-5 12015221-1 2002 The semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) from crude homogenates of human dental pulp was shown to catalyse the oxidative deamination of 5-hydroxytryptamine (serotonin; 5-HT) with a K(m) of 318+/-52 microM. Serotonin 177-186 amine oxidase copper containing 2 Homo sapiens 4-41 12015221-1 2002 The semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) from crude homogenates of human dental pulp was shown to catalyse the oxidative deamination of 5-hydroxytryptamine (serotonin; 5-HT) with a K(m) of 318+/-52 microM. Serotonin 177-186 amine oxidase copper containing 2 Homo sapiens 55-59 26034313-7 2015 Monkeys carrying a relatively infrequent "long" allele of TPH2, a regulatory gene that influences serotonin production in the brain, were significantly less vigilant compared to monkeys that did not carry the allele. Serotonin 98-107 tryptophan hydroxylase 2 Macaca mulatta 58-62 11952922-1 2002 Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]). Serotonin 88-97 5-hydroxytryptamine receptor 1A Homo sapiens 108-131 11952922-1 2002 Tandospirone citrate (tandospirone) is an anti-anxiety drug that acts by combining with serotonin receptor (5-hydroxytryptamine-1 A [5-HT1A]). Serotonin 88-97 5-hydroxytryptamine receptor 1A Homo sapiens 133-139 16019587-11 2004 Finally, we observed reduced responses to serotonin in the CA1 area, which could contribute to the onset of symptoms of depression in predisposed individuals. Serotonin 42-51 carbonic anhydrase 1 Rattus norvegicus 59-62 25765937-10 2015 Serotonin can increase ERalpha expression in hPASMCs and antagonism of ERalpha reverses serotonin-dependent PH in the mouse and increases BMPR2 expression. Serotonin 0-9 estrogen receptor 1 (alpha) Mus musculus 23-30 15175423-2 2004 We have previously shown that withdrawal after 14 days of cocaine treatment produces a supersensitivity of hypothalamic 5-hydroxytryptamine (serotonin) 2A (5-HT(2A)) receptors, which is accompanied by increases in the levels of Galpha(q) and Galpha(11) proteins. Serotonin 120-139 G protein subunit alpha 11 Rattus norvegicus 242-252 11999724-3 2002 We tested whether the functional responses of CA1 hippocampal cells to serotonin are also reduced in long attack latency mice. Serotonin 71-80 carbonic anhydrase 1 Mus musculus 46-49 11999724-4 2002 To this end, serotonin-induced changes in the membrane potential and input resistance were recorded in vitro with microelectrodes in CA1 pyramidal neurones of long and short attack latency mice. Serotonin 13-22 carbonic anhydrase 1 Mus musculus 133-136 25765937-10 2015 Serotonin can increase ERalpha expression in hPASMCs and antagonism of ERalpha reverses serotonin-dependent PH in the mouse and increases BMPR2 expression. Serotonin 88-97 estrogen receptor 1 (alpha) Mus musculus 71-78 25773578-1 2015 In our previous paper, we have reported that some 8-alkoxy-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives possessed high affinity and displayed agonistic activity for the serotonin 5-HT1A receptor. Serotonin 176-185 5-hydroxytryptamine receptor 1A Homo sapiens 186-201 11804958-7 2002 Production of PAF and lyso-PAF was measured with a biological assay using [3H]serotonin release from rabbit platelets. Serotonin 78-87 PCNA clamp associated factor Homo sapiens 14-17 15360211-0 2004 A new class of arylpiperazine derivatives: the library synthesis on SynPhase lanterns and biological evaluation on serotonin 5-HT(1A) and 5-HT(2A) receptors. Serotonin 115-124 5-hydroxytryptamine receptor 1A Homo sapiens 125-132 25613051-9 2015 Methylene blue and its metabolite, azure B, are potent, reversible inhibitors of monoamine oxidase A which is responsible for serotonin metabolism. Serotonin 126-135 monoamine oxidase A Homo sapiens 81-100 15341530-5 2004 We have cloned the 5"-terminal oligopyrimidine mRNA encoding eukaryotic elongation factor 2 and shown that serotonin increased its translation in synaptosomes. Serotonin 107-116 eukaryotic translation elongation factor 2 Homo sapiens 72-91 15341530-8 2004 Serotonin application decreased eukaryotic elongation factor 2 phosphorylation in synaptosomes and in isolated neurites, and this was blocked by rapamycin. Serotonin 0-9 eukaryotic translation elongation factor 2 Homo sapiens 43-62 11804958-7 2002 Production of PAF and lyso-PAF was measured with a biological assay using [3H]serotonin release from rabbit platelets. Serotonin 78-87 PCNA clamp associated factor Homo sapiens 27-30 12065904-5 2002 To test this hypothesis, we evaluated the potential of histamine or serotonin to induce the release of eotaxin by the human fetal lung fibroblast cell line, HFL-1. Serotonin 68-77 complement factor H related 1 Homo sapiens 157-162 12065904-6 2002 HFL-1 released eotaxin in response to histamine and serotonin in a dose- and time-dependent manner (p < 0.05). Serotonin 52-61 complement factor H related 1 Homo sapiens 0-5 12065904-7 2002 Histamine or serotonin treatment of HFL-1 augmented the expression of eotaxin mRNA. Serotonin 13-22 complement factor H related 1 Homo sapiens 36-41 25514185-2 2015 We aimed to correlate clinical phenotypes of 55 children with neurodevelopmental disorders with dopamine (HVA) and serotonin (5-HIIA) metabolites in CSF. Serotonin 115-124 colony stimulating factor 2 Homo sapiens 149-152 11795484-4 2001 However, low concentrations of 5-HT (2 microM) potentiated platelet aggregation induced by subthreshold concentration of PAF (40 nM) indicating a synergistic interaction between the two agonists and this synergism was blocked by receptor antagonists to either 5-HT or PAF. Serotonin 31-35 PCNA clamp associated factor Homo sapiens 121-124 11795484-4 2001 However, low concentrations of 5-HT (2 microM) potentiated platelet aggregation induced by subthreshold concentration of PAF (40 nM) indicating a synergistic interaction between the two agonists and this synergism was blocked by receptor antagonists to either 5-HT or PAF. Serotonin 31-35 PCNA clamp associated factor Homo sapiens 268-271 11795484-4 2001 However, low concentrations of 5-HT (2 microM) potentiated platelet aggregation induced by subthreshold concentration of PAF (40 nM) indicating a synergistic interaction between the two agonists and this synergism was blocked by receptor antagonists to either 5-HT or PAF. Serotonin 260-264 PCNA clamp associated factor Homo sapiens 121-124 12101361-7 2001 Furthermore, serotonin was found to inhibit the MVN neuronal activities via the 5-HT1A receptors. Serotonin 13-22 5-hydroxytryptamine receptor 1A Homo sapiens 80-86 15158072-1 2004 Previously, this laboratory showed that in utero and in vitro ethanol exposure significantly reduces developing serotonin (5-HT) neurons and that treatment with a 5-HT1A agonist such as buspirone or ipsapirone prevents the ethanol-associated loss. Serotonin 112-121 5-hydroxytryptamine receptor 1A Homo sapiens 163-169 15016478-6 2004 Platelet pre-incubation with 5HT(1A) and 5HT(2A) antagonists, pindobind and ritanserin, significantly inhibited serotonin-mediated kinase activation with an EC(50) of 3.2 +/- 0.2 and 1.99 +/- 0.08 nM, respectively, suggesting an involvement of these specific receptor subtypes in serotonin-mediated response. Serotonin 112-121 5-hydroxytryptamine receptor 1A Homo sapiens 29-35 25712017-1 2015 The firing activity of serotonergic neurons in raphe nuclei is regulated by negative feedback exerted by extracellular serotonin (5-HT)o acting through somatodendritic 5-HT1A autoreceptors. Serotonin 119-128 5-hydroxytryptamine receptor 1A Homo sapiens 168-174 15145704-1 2004 We recently demonstrated that mice lacking the gene for substance P (neurokinin 1) receptors (NK1-/-) show improved cortical dialysate serotonin (5-HT) responses to paroxetine [J. Neurosci. Serotonin 135-144 tachykinin 1 Mus musculus 56-67 15145704-1 2004 We recently demonstrated that mice lacking the gene for substance P (neurokinin 1) receptors (NK1-/-) show improved cortical dialysate serotonin (5-HT) responses to paroxetine [J. Neurosci. Serotonin 135-144 tachykinin 1 Mus musculus 69-81 11743138-1 2001 Long-term potentiation of sympathetic ganglia (gLTP), a unique form of synaptic plasticity, is serotonin dependent and can be blocked with 5-HT3 receptor antagonists. Serotonin 95-104 glycolipid transfer protein Rattus norvegicus 47-51 11706103-1 2001 BACKGROUND: [(11)C] alpha-methyl-L-tryptophan (alpha-MTrp) has been developed as a tracer for the study of the synthesis of serotonin in the brain with PET. Serotonin 124-133 lysosomal protein transmembrane 4 alpha Homo sapiens 53-57 15145704-1 2004 We recently demonstrated that mice lacking the gene for substance P (neurokinin 1) receptors (NK1-/-) show improved cortical dialysate serotonin (5-HT) responses to paroxetine [J. Neurosci. Serotonin 135-144 tachykinin 1 Mus musculus 94-97 24915981-0 2015 Attenuation of serotonin-induced itch responses by inhibition of endocannabinoid degradative enzymes, fatty acid amide hydrolase and monoacylglycerol lipase. Serotonin 15-24 fatty acid amide hydrolase Mus musculus 113-128 15088153-3 2004 One of the key enzymes in the degradation of serotonin and to a lesser extent of dopamine is monoamine oxidase A (MAO-A). Serotonin 45-54 monoamine oxidase A Homo sapiens 114-119 11706103-3 2001 Increased levels of serotonin and quinolinic acid have been described in resected epileptogenic cortex, raising the possibility that alpha-MTrp can localize seizure foci in patients with intractable partial epilepsy. Serotonin 20-29 lysosomal protein transmembrane 4 alpha Homo sapiens 139-143 24872079-0 2015 Endogenous serotonin facilitates hippocampal long-term potentiation at CA3/CA1 synapses. Serotonin 11-20 carbonic anhydrase 1 Rattus norvegicus 75-78 11640963-0 2001 Histamine H1 receptor-mediated inhibition of potassium-evoked release of 5-hydroxytryptamine from mouse forebrains. Serotonin 73-92 histamine receptor H1 Mus musculus 0-21 11455205-0 2001 Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation. Serotonin 41-50 C-C motif chemokine ligand 2 Homo sapiens 0-30 15173897-0 2004 Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response. Serotonin 49-58 tachykinin receptor 1 Rattus norvegicus 10-30 25497735-8 2015 In view of the crucial role of serotonin in brain development, these findings suggest that the enduring outcome of neonatal treatment with fluoxetine may be due to MeCP2-dependent restoration of the 5-HT1A-R. Serotonin 31-40 methyl CpG binding protein 2 Mus musculus 164-169 15116257-3 2004 Platelets from a SEPT5 knockout mouse showed an altered serotonin secretion and platelet aggregation, suggesting that SEPT5 is involved in secretion in platelets. Serotonin 56-65 septin 5 Mus musculus 17-22 15116257-3 2004 Platelets from a SEPT5 knockout mouse showed an altered serotonin secretion and platelet aggregation, suggesting that SEPT5 is involved in secretion in platelets. Serotonin 56-65 septin 5 Mus musculus 118-123 25108244-8 2015 Based on growing evidence pointing to a medial prefrontal cortex-amygdala system in mediating adaptive and maladaptive stress responses, we propose a brain circuit in which serotonin neurons in the dorsal raphe depending on the CRF (corticotropin releasing factor) regulatory action engage a prefrontal cortical-amygdala pathway through 5-HT1A receptors, GABA and Glutamate to moderate coping behavior. Serotonin 173-182 corticotropin releasing hormone Homo sapiens 233-263 15170061-8 2004 We confirmed that GA-ir fibers were closely associated with serotonin-ir neurons in the PVO and IF. Serotonin 60-69 galanin peptides Coturnix japonica 18-20 25757927-0 2015 Serotonin regulates beta-casein expression via 5-HT7 receptors in human mammary epithelial MCF-12A cells. Serotonin 0-9 casein beta Homo sapiens 20-31 15170061-9 2004 GA-ir neurons have at least 2 routes of regulating GnRH neurons directly, and indirectly via the serotonin-ir cells in the PVO and IF. Serotonin 97-106 galanin peptides Coturnix japonica 0-2 25757927-1 2015 We previously reported that serotonin (5-hydroxytryptamine; 5-HT) suppresses beta-casein expression, a differentiation marker in mammary epithelial cells, via inhibition of the signal transducer and activator of transcription 5 (STAT5) phosphorylation in the human mammary epithelial cell line, MCF-12A. Serotonin 28-37 casein beta Homo sapiens 77-88 25757927-1 2015 We previously reported that serotonin (5-hydroxytryptamine; 5-HT) suppresses beta-casein expression, a differentiation marker in mammary epithelial cells, via inhibition of the signal transducer and activator of transcription 5 (STAT5) phosphorylation in the human mammary epithelial cell line, MCF-12A. Serotonin 28-37 signal transducer and activator of transcription 5A Homo sapiens 177-227 15048901-1 2004 We report that administration of paroxetine, a widely prescribed antidepressant drug that acts by inhibiting reuptake of the neurotransmitter serotonin, suppresses the neurodegenerative process and increases the survival of huntingtin mutant mice, an animal model of Huntington"s disease (HD). Serotonin 142-151 huntingtin Mus musculus 224-234 25757927-1 2015 We previously reported that serotonin (5-hydroxytryptamine; 5-HT) suppresses beta-casein expression, a differentiation marker in mammary epithelial cells, via inhibition of the signal transducer and activator of transcription 5 (STAT5) phosphorylation in the human mammary epithelial cell line, MCF-12A. Serotonin 28-37 signal transducer and activator of transcription 5A Homo sapiens 229-234 25757927-1 2015 We previously reported that serotonin (5-hydroxytryptamine; 5-HT) suppresses beta-casein expression, a differentiation marker in mammary epithelial cells, via inhibition of the signal transducer and activator of transcription 5 (STAT5) phosphorylation in the human mammary epithelial cell line, MCF-12A. Serotonin 39-58 casein beta Homo sapiens 77-88 25757927-1 2015 We previously reported that serotonin (5-hydroxytryptamine; 5-HT) suppresses beta-casein expression, a differentiation marker in mammary epithelial cells, via inhibition of the signal transducer and activator of transcription 5 (STAT5) phosphorylation in the human mammary epithelial cell line, MCF-12A. Serotonin 39-58 signal transducer and activator of transcription 5A Homo sapiens 177-227 14976250-4 2004 In a high-throughput screen for small molecules capable of regulating MCIP1 expression in muscle cells, we identified a unique 4-aminopyridine derivative exhibiting an embedded partial structural motif of serotonin (5-hydroxytryptamine, 5-HT). Serotonin 205-214 regulator of calcineurin 1 Homo sapiens 70-75 14976250-4 2004 In a high-throughput screen for small molecules capable of regulating MCIP1 expression in muscle cells, we identified a unique 4-aminopyridine derivative exhibiting an embedded partial structural motif of serotonin (5-hydroxytryptamine, 5-HT). Serotonin 216-235 regulator of calcineurin 1 Homo sapiens 70-75 25757927-1 2015 We previously reported that serotonin (5-hydroxytryptamine; 5-HT) suppresses beta-casein expression, a differentiation marker in mammary epithelial cells, via inhibition of the signal transducer and activator of transcription 5 (STAT5) phosphorylation in the human mammary epithelial cell line, MCF-12A. Serotonin 39-58 signal transducer and activator of transcription 5A Homo sapiens 229-234 24807817-1 2015 Animal studies suggest that serotonin, mediated by the 5-HT1A receptor, plays a key role in spatial learning and memory. Serotonin 28-37 5-hydroxytryptamine receptor 1A Homo sapiens 55-70 14976250-4 2004 In a high-throughput screen for small molecules capable of regulating MCIP1 expression in muscle cells, we identified a unique 4-aminopyridine derivative exhibiting an embedded partial structural motif of serotonin (5-hydroxytryptamine, 5-HT). Serotonin 237-241 regulator of calcineurin 1 Homo sapiens 70-75 26502818-8 2015 Negative correlations between the levels of 5-HT and Abeta were evident in the amygdala, but not in the hippocampus. Serotonin 44-48 amyloid beta (A4) precursor protein Mus musculus 53-58 25817861-0 2015 The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study. Serotonin 86-95 piccolo presynaptic cytomatrix protein Homo sapiens 4-11 14962671-3 2004 The monoamine oxidases A and B (MAO-A and -B) genes, which are involved in serotonin and dopamine metabolism, are possible candidate genes for susceptibility to PD. Serotonin 75-84 monoamine oxidase A Homo sapiens 32-44 25326539-3 2015 Tumor growth and angiogenesis induced by VEGF-A, histamine, and serotonin are almost completely inhibited in Nur77 knockout mice. Serotonin 64-73 nuclear receptor subfamily 4, group A, member 1 Mus musculus 109-114 14720318-1 2004 The 5-HT1A/beta-adrenoceptor ligand (+/-)pindolol has been used in clinical trials to enhance the antidepressant effect of selective serotonin (5-HT) reuptake inhibitors (SSRIs). Serotonin 133-142 5-hydroxytryptamine receptor 1A Homo sapiens 4-10 24809685-10 2015 However, the presently observed trend towards CpG-specific MAO-A gene hypomethylation-possibly via increased gene expression and consecutively decreased serotonin and/or norepinephrine availability-to potentially drive impaired antidepressant treatment response in female patients might be worthwhile to be followed up in larger pharmacoepigenetic studies. Serotonin 153-162 monoamine oxidase A Homo sapiens 59-64 14718257-0 2004 5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide. Serotonin 0-19 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 41-47 25584932-4 2015 Black and Hispanic populations are known to have a higher prevalence of cardiovascular risk factors and disease, and a substantial proportion of black and Hispanic individuals possess genotypes of the cytochrome P450 (CYP) 2C9 enzyme involved in the metabolism of many NSAIDs and the CYP2D6 enzyme involved in metabolism of the dual opioid agonist/norepinephrine-serotonin reuptake inhibitor tramadol. Serotonin 363-372 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 201-226 14754568-7 2004 Although CPF exposure on GD17-20, PN1-4, or PN11-14 altered the ability of 5HT to modulate adenylyl cyclase, this change did not correspond with the effects on 5HT receptors, suggesting an additional set of effects on proteins that transduce the 5HT signal. Serotonin 75-78 serpin family E member 2 Homo sapiens 34-39 15021971-1 2004 OBJECTIVE AND DESIGN: The aim of this study was to investigate whether leukotrienes synthesized by 5-lipoxygenase (5-LO) and acting via leukotriene (LT) receptors contribute to 5-hydroxytryptamine (5-HT)-induced knee joint plasma extravasation (PE). Serotonin 177-196 arachidonate 5-lipoxygenase Rattus norvegicus 99-113 24817649-7 2014 Although not estrogenic, Nomega -methylserotonin has been identified in black cohosh as a potent agonist of serotonin 5-HT1A and 5-HT7 receptors. Serotonin 39-48 5-hydroxytryptamine receptor 1A Homo sapiens 118-144 14725625-8 2004 The density of serotonin (5-HT) innervation of the strata lacunosum moleculare and radiatum of the CA1 region of the hippocampus was reduced in response to estradiol, as shown by a decrease in the length of fibers (27.6 and 48.3% decrease, respectively) and the number of large varicosities (32.5 and 38.8% decrease, respectively). Serotonin 15-24 carbonic anhydrase 1 Rattus norvegicus 99-102 25220264-1 2014 Monoamine oxidases (MAOs) A and B are flavoenzymes responsible for the metabolism of biogenic amines such as dopamine, serotonin and noradrenaline. Serotonin 119-128 monoamine oxidase A Homo sapiens 0-33 14697876-10 2004 MAO-A oxidizes noradrenaline and serotonin; and MAO-B, mainly beta-phenylethylamine. Serotonin 33-42 monoamine oxidase A Homo sapiens 0-5 14697899-5 2004 The cheese reaction is a consequence of inhibition of MAO-A, the enzyme responsible for metabolism of noradrenaline and serotonin, located in peripheral adrenergic neurons. Serotonin 120-129 monoamine oxidase A Homo sapiens 54-59 25192038-0 2014 Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling. Serotonin 0-9 sonic hedgehog Mus musculus 81-89 25041947-1 2014 AIMS: Positron emission tomography (PET) imaging using 5-HT1A receptor radioligands shows a decreased expression of this serotonin receptor in the hippocampus of patients with Alzheimer"s disease (AD) at advanced stages. Serotonin 121-130 5-hydroxytryptamine receptor 1A Homo sapiens 55-70 14980728-3 2004 Parallel immunohistochemistry studies showing serotonin fibers contacting calbindin- and parvalbumin-positive neurons have led to the assumption that raphe fibers projecting on these types of neurons are mainly serotonergic. Serotonin 46-55 calbindin 1 Homo sapiens 74-84 25157819-3 2014 Estrogen-dependent inhibition of binge-like eating was blocked in female mice specifically lacking estrogen receptor-alpha (ERalpha) in serotonin (5-HT) neurons in the dorsal raphe nuclei (DRN). Serotonin 136-145 estrogen receptor 1 (alpha) Mus musculus 124-131 12958079-14 2003 This 4.96 Mb region contains, among others, the genes for monoamine oxidase A (MAOA) and B (MAOB), which are involved in the oxidative deamination of several neurotransmitters, including dopamine and serotonin. Serotonin 200-209 monoamine oxidase A Homo sapiens 58-77 23761378-1 2014 OBJECTIVES: Monoamine oxidase A (MAOA) modulates metabolism of serotonin and dopamine metabolism, neurotransmitters involved in regulation of appetite and food intake. Serotonin 63-72 monoamine oxidase A Homo sapiens 12-31 12958079-14 2003 This 4.96 Mb region contains, among others, the genes for monoamine oxidase A (MAOA) and B (MAOB), which are involved in the oxidative deamination of several neurotransmitters, including dopamine and serotonin. Serotonin 200-209 monoamine oxidase A Homo sapiens 79-83 14592780-0 2003 Cytokine-serotonin interaction through IDO: a neurodegeneration hypothesis of depression. Serotonin 9-18 indoleamine 2,3-dioxygenase 1 Homo sapiens 39-42 14592780-4 2003 Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. Serotonin 105-114 indoleamine 2,3-dioxygenase 1 Homo sapiens 134-161 14592780-4 2003 Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. Serotonin 105-114 indoleamine 2,3-dioxygenase 1 Homo sapiens 163-166 14592780-4 2003 Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. Serotonin 218-222 indoleamine 2,3-dioxygenase 1 Homo sapiens 134-161 23761378-1 2014 OBJECTIVES: Monoamine oxidase A (MAOA) modulates metabolism of serotonin and dopamine metabolism, neurotransmitters involved in regulation of appetite and food intake. Serotonin 63-72 monoamine oxidase A Homo sapiens 33-37 25802735-0 2014 Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Serotonin 45-54 solute carrier family 29 member 4 Homo sapiens 91-128 14592780-4 2003 Recently, pro-inflammatory cytokines have been found to have profound effects on the metabolism of brain serotonin through the enzyme indoleamine-2,3-dioxygenase (IDO) that metabolizes the tryptophan, the precursor of 5-HT to neurodegenerative quinolinate and neuroprotective kynurenate. Serotonin 218-222 indoleamine 2,3-dioxygenase 1 Homo sapiens 163-166 25802735-0 2014 Autism spectrum disorder associated with low serotonin in CSF and mutations in the SLC29A4 plasma membrane monoamine transporter (PMAT) gene. Serotonin 45-54 solute carrier family 29 member 4 Homo sapiens 130-134 25802735-7 2014 Expression of mutations PMAT-p.Ala138Thr and p.Asp326Glu in cellulae revealed significant reduced transport uptake activity towards a variety of substrates including serotonin, dopamine, and 1-methyl-4-phenylpyridinium (MPP(+)), while mutation p.Asp29Gly had reduced transport activity only towards MPP(+). Serotonin 166-175 solute carrier family 29 member 4 Homo sapiens 24-28 25802735-8 2014 At least two ASD subjects with either the PMAT-Ala138Thr or the PMAT-Asp326Glu mutation with altered serotonin transport activity had, besides low 5HIAA in CSF, elevated serotonin levels in blood and platelets. Serotonin 101-110 solute carrier family 29 member 4 Homo sapiens 42-46 25802735-8 2014 At least two ASD subjects with either the PMAT-Ala138Thr or the PMAT-Asp326Glu mutation with altered serotonin transport activity had, besides low 5HIAA in CSF, elevated serotonin levels in blood and platelets. Serotonin 101-110 solute carrier family 29 member 4 Homo sapiens 64-68 12855685-1 2003 Monoamine oxidase (MAO) A and B catalyze the oxidative deamination of neuroactive and dietary monoamines such as serotonin, tyramine, and phenylethylamine. Serotonin 113-122 monoamine oxidase A Homo sapiens 0-25 11306635-0 2001 Regulation of serotonin release in the lateral septum and striatum by corticotropin-releasing factor. Serotonin 14-23 corticotropin releasing hormone Homo sapiens 70-100 25802735-8 2014 At least two ASD subjects with either the PMAT-Ala138Thr or the PMAT-Asp326Glu mutation with altered serotonin transport activity had, besides low 5HIAA in CSF, elevated serotonin levels in blood and platelets. Serotonin 170-179 solute carrier family 29 member 4 Homo sapiens 42-46 25802735-8 2014 At least two ASD subjects with either the PMAT-Ala138Thr or the PMAT-Asp326Glu mutation with altered serotonin transport activity had, besides low 5HIAA in CSF, elevated serotonin levels in blood and platelets. Serotonin 170-179 solute carrier family 29 member 4 Homo sapiens 64-68 24752854-0 2014 Serotonin (5-HT) regulates neurite outgrowth through 5-HT1A and 5-HT7 receptors in cultured hippocampal neurons. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 53-59 11304467-0 2001 Role of sex differences and effects of endothelial NO synthase deficiency in responses of carotid arteries to serotonin. Serotonin 110-119 nitric oxide synthase 3, endothelial cell Mus musculus 39-62 11304467-1 2001 We examined the hypothesis that contraction of the carotid arteries to serotonin is normally inhibited by endothelial NO synthase (eNOS) and is enhanced in mice lacking the gene for eNOS. Serotonin 71-80 nitric oxide synthase 3, endothelial cell Mus musculus 106-129 11304467-1 2001 We examined the hypothesis that contraction of the carotid arteries to serotonin is normally inhibited by endothelial NO synthase (eNOS) and is enhanced in mice lacking the gene for eNOS. Serotonin 71-80 nitric oxide synthase 3, endothelial cell Mus musculus 131-135 14615704-2 2003 The onset of antidepressant action of Serotonin (5HT) selective reuptake inhibitors (SSRIs) was attributed in part to the decrease in firing activity of serotonin neurons produced by the activation of raphe 5HT1A autoreceptors at the time of treatment initiation. Serotonin 38-47 5-hydroxytryptamine receptor 1A Homo sapiens 207-212 14615704-2 2003 The onset of antidepressant action of Serotonin (5HT) selective reuptake inhibitors (SSRIs) was attributed in part to the decrease in firing activity of serotonin neurons produced by the activation of raphe 5HT1A autoreceptors at the time of treatment initiation. Serotonin 49-52 5-hydroxytryptamine receptor 1A Homo sapiens 207-212 14615704-2 2003 The onset of antidepressant action of Serotonin (5HT) selective reuptake inhibitors (SSRIs) was attributed in part to the decrease in firing activity of serotonin neurons produced by the activation of raphe 5HT1A autoreceptors at the time of treatment initiation. Serotonin 153-162 5-hydroxytryptamine receptor 1A Homo sapiens 207-212 11304467-1 2001 We examined the hypothesis that contraction of the carotid arteries to serotonin is normally inhibited by endothelial NO synthase (eNOS) and is enhanced in mice lacking the gene for eNOS. Serotonin 71-80 nitric oxide synthase 3, endothelial cell Mus musculus 182-186 24904340-7 2014 Glutamate, serotonin, noradrenaline, and histamine are activated by stress and exert an inhibitory effect on serotonin outflow, in part by "flooding" 5-HT1A autoreceptors by serotonin itself. Serotonin 11-20 5-hydroxytryptamine receptor 1A Homo sapiens 150-156 11304467-4 2001 Contraction to serotonin was greater in male eNOS(+/+) mice than in female eNOS(+/+) mice. Serotonin 15-24 nitric oxide synthase 3, endothelial cell Mus musculus 45-49 11304467-4 2001 Contraction to serotonin was greater in male eNOS(+/+) mice than in female eNOS(+/+) mice. Serotonin 15-24 nitric oxide synthase 3, endothelial cell Mus musculus 75-79 11304467-5 2001 In male mice, contraction to serotonin increased by approximately 40% and 2.5-fold in male eNOS(+/-) and eNOS(-/-) mice, respectively. Serotonin 29-38 nitric oxide synthase 3, endothelial cell Mus musculus 91-95 11304467-5 2001 In male mice, contraction to serotonin increased by approximately 40% and 2.5-fold in male eNOS(+/-) and eNOS(-/-) mice, respectively. Serotonin 29-38 nitric oxide synthase 3, endothelial cell Mus musculus 105-109 11304467-6 2001 Contraction to serotonin was more than doubled in female eNOS(+/-) mice and increased >5-fold in arteries from eNOS(-/-) mice. Serotonin 15-24 nitric oxide synthase 3, endothelial cell Mus musculus 57-61 14513797-5 2003 IL-1ra (1 x 10(-7)-1 x 10(-5) mol.L-1) concentration-dependently inhibited the contraction of TSM induced by 1 x 10(-3) mol.L-1 histamine (His), 1 x 10(-3) mol.L-1 acetylcholine (ACh) and 1 x 10(-6) mol.L-1 5-hydroxytryptamine (5-HT) (P < 0.05 or 0.01). Serotonin 228-232 interleukin 1 receptor antagonist Homo sapiens 0-6 12759158-4 2003 Assuming that genes regulating the serotonin system are involved in the pathogenesis of panic disorder, the authors searched for a genetic association of panic disorder with the serotonin 1A (HTR1A), 2A (HTR2A), and 2C (HTR2C) receptor genes. Serotonin 35-44 5-hydroxytryptamine receptor 1A Homo sapiens 192-197 11304467-6 2001 Contraction to serotonin was more than doubled in female eNOS(+/-) mice and increased >5-fold in arteries from eNOS(-/-) mice. Serotonin 15-24 nitric oxide synthase 3, endothelial cell Mus musculus 114-118 11304467-10 2001 eNOS deficiency in gene-targeted mice is associated with enhanced contraction to serotonin, particularly in female mice, providing direct evidence that eNOS is a major determinant of vascular effects of serotonin. Serotonin 81-90 nitric oxide synthase 3, endothelial cell Mus musculus 0-4 11304467-10 2001 eNOS deficiency in gene-targeted mice is associated with enhanced contraction to serotonin, particularly in female mice, providing direct evidence that eNOS is a major determinant of vascular effects of serotonin. Serotonin 203-212 nitric oxide synthase 3, endothelial cell Mus musculus 0-4 11304467-10 2001 eNOS deficiency in gene-targeted mice is associated with enhanced contraction to serotonin, particularly in female mice, providing direct evidence that eNOS is a major determinant of vascular effects of serotonin. Serotonin 203-212 nitric oxide synthase 3, endothelial cell Mus musculus 152-156 11304467-11 2001 The results with eNOS(+/-) mice suggest a "gene-dosing" effect for vascular responses to serotonin. Serotonin 89-98 nitric oxide synthase 3, endothelial cell Mus musculus 17-21 24904340-7 2014 Glutamate, serotonin, noradrenaline, and histamine are activated by stress and exert an inhibitory effect on serotonin outflow, in part by "flooding" 5-HT1A autoreceptors by serotonin itself. Serotonin 109-118 5-hydroxytryptamine receptor 1A Homo sapiens 150-156 24904340-7 2014 Glutamate, serotonin, noradrenaline, and histamine are activated by stress and exert an inhibitory effect on serotonin outflow, in part by "flooding" 5-HT1A autoreceptors by serotonin itself. Serotonin 109-118 5-hydroxytryptamine receptor 1A Homo sapiens 150-156 11259568-9 2001 Furthermore, administration of the 5-HT(1A) and 5-HT7 agonist 8-hydroxydipropylaminotetralin mimicked and antagonized the effect of serotonin, suggesting it acted as a partial agonist. Serotonin 132-141 5-hydroxytryptamine receptor 1A Homo sapiens 35-42 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 85-104 monoamine oxidase A Homo sapiens 0-19 11316327-1 2001 Serotonin N-acetyltransferase (AANAT; EC 2.3.1.87) metabolizes serotonin into N-acetylserotonin (NAS). Serotonin 63-72 arylalkylamine N-acetyltransferase Mus musculus 0-29 11316327-1 2001 Serotonin N-acetyltransferase (AANAT; EC 2.3.1.87) metabolizes serotonin into N-acetylserotonin (NAS). Serotonin 63-72 arylalkylamine N-acetyltransferase Mus musculus 31-36 11171669-2 2001 Previously, we showed that serotonin-induced production of IL-1alpha by myometrial smooth muscle cells in vitro is also essential for the synthesis of interstitial collagenase. Serotonin 27-36 matrix metallopeptidase 1 Rattus norvegicus 151-175 12626670-1 2003 The modulatory effects of serotonin mediated by 5-HT1A receptors in adult spinal motoneurons were investigated by intracellular recordings in a slice preparation from the turtle. Serotonin 26-35 5-hydroxytryptamine receptor 1A Homo sapiens 48-54 12626670-6 2003 Our results show that activation of 5-HT1A receptors contributes to the excitatory effect of serotonin on spinal motoneurons by inhibition of a TASK-1 potassium channel leading to depolarization and increased input resistance. Serotonin 93-102 5-hydroxytryptamine receptor 1A Homo sapiens 36-42 12668044-1 2003 Previously we have shown that 17beta-estradiol (in vivo and in vitro) rapidly decreases the function of serotonin(1A) (5-HT(1A)) receptors, allowing us to hypothesize that 17beta-estradiol accomplished this via activation of a membrane estrogen receptor. Serotonin 104-113 estrogen receptor 1 Rattus norvegicus 236-253 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 85-104 monoamine oxidase A Homo sapiens 21-25 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 106-110 monoamine oxidase A Homo sapiens 0-19 12595443-5 2003 Furthermore, the genetic contribution of Bphs/Hrh1 to vasoactive amine sensitization is specific for histamine, since hypersensitivity to serotonin was unaffected by Bphs/Hrh1. Serotonin 138-147 histamine receptor H1 Mus musculus 41-45 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 106-110 monoamine oxidase A Homo sapiens 21-25 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 112-121 monoamine oxidase A Homo sapiens 0-19 11120396-1 2001 The present study was performed to examine an overall effect of endogenous serotonin (5-HT) on the spontaneous firing activity of the dorsal hippocampus CA1 pyramidal neurons in quiet awake rats. Serotonin 75-84 carbonic anhydrase 1 Rattus norvegicus 153-156 24510409-1 2014 Monoamine oxidase A (MAOA) catalyzes monoamine neurotransmitters including dopamine, 5-hydroxytryptamine (5-HT, serotonin), and norepinephrine. Serotonin 112-121 monoamine oxidase A Homo sapiens 21-25 12584728-9 2003 Up-regulation of OCT3 expression and enhanced low-affinity 5HT uptake may limit the adverse effects of elevated extracellular 5HT and may play a critical role in maintaining 5HT-dependent functions of the hippocampus in the absence of 5HTT. Serotonin 126-129 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 17-21 12584728-9 2003 Up-regulation of OCT3 expression and enhanced low-affinity 5HT uptake may limit the adverse effects of elevated extracellular 5HT and may play a critical role in maintaining 5HT-dependent functions of the hippocampus in the absence of 5HTT. Serotonin 126-129 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 17-21 24559277-1 2014 OBJECT: The biogenic amines (dopamine, epinephrine, norepinephrine, and serotonin) are involved in the regulation of multiple neuronal functions, and changes in monoamine concentrations in the CSF have been detected in several disorders. Serotonin 72-81 colony stimulating factor 2 Homo sapiens 193-196 11481861-1 2001 We reported a 74-year-old male case of progressive supranuclear palsy (PSP) who responded to tandospirone citrate, a serotonin receptor (5-HT1A) agonist. Serotonin 117-126 5-hydroxytryptamine receptor 1A Homo sapiens 137-143 24429224-2 2014 In particular, much interest is focused on the understanding of clozapine activity on serotonin (5-HT) neurotransmission, particularly on 5-HT receptor of type 1A (5-HT(1A)) that seems to play a pivotal role in the control of the 5-HT system. Serotonin 86-95 5-hydroxytryptamine receptor 1A Homo sapiens 164-171 11173978-2 2001 The ADH1 enzymes, the classical liver forms, are involved in several metabolic pathways beside the oxidation of ethanol, e.g. norepinephrine, dopamine, serotonin and bile acid metabolism. Serotonin 152-161 alcohol dehydrogenase 1A (class I), alpha polypeptide Homo sapiens 4-8 12509487-1 2003 Functional coupling between Ca(2+)-induced Ca(2+) release (CICR) and quantal exocytosis in 5-hydroxytryptamine-loaded INS-1 beta cells was assessed through the use of carbon fibre amperometry in combination with Fura-2. Serotonin 91-110 insulin 1 Rattus norvegicus 118-123 12849755-4 2003 Functionally, interleukin-1 has been shown to induce the release of serotonin (5-HT), a neurotransmitter known to potently affect aggression and rage behavior. Serotonin 68-77 interleukin 1 alpha Homo sapiens 14-27 11152718-4 2001 CC3 is immunopositive for serotonin and may be the same cell (CB-1) previously described as located in the B cluster rather than the C cluster. Serotonin 26-35 C-C motif chemokine ligand 14 Homo sapiens 0-3 24874107-2 2014 The past 2 decades have witnessed a dramatic increase in the number of effective antiemetic agents, with the introduction of the serotonin (5-hydroxytryptamine [5-HT3]) receptor antagonists (ondansetron, granisetron, and palonosetron), the neurokinin-1 (NK1) receptor antagonists (aprepitant and fosaprepitant), and the identification of other agents that have demonstrated efficacy against CINV, including corticosteroids. Serotonin 129-138 tachykinin receptor 1 Homo sapiens 240-267 11889652-3 2001 The neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP), and neuropeptide Y (NPY) have all been found at high levels in the synovial fluid of arthritic TMJs in association with spontaneous pain, while serotonin (5-HT) has been found in association with hyperalgesia/allodynia of the TMJ. Serotonin 220-229 neuropeptide Y Homo sapiens 80-94 11889652-3 2001 The neuropeptides substance P (SP), calcitonin gene-related peptide (CGRP), and neuropeptide Y (NPY) have all been found at high levels in the synovial fluid of arthritic TMJs in association with spontaneous pain, while serotonin (5-HT) has been found in association with hyperalgesia/allodynia of the TMJ. Serotonin 220-229 neuropeptide Y Homo sapiens 96-99 12472894-1 2002 The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. Serotonin 129-138 ApC/EBP Aplysia californica 26-33 12472894-1 2002 The transcription factor, ApC/EBP (Aplysia CCAAT enhancer-binding protein) is an immediate early gene that is rapidly induced by serotonin and the cAMP signaling pathway. Serotonin 129-138 ApC/EBP Aplysia californica 35-73 23982114-2 2014 Of particular interest is OCT3 expression and function in the brain, where it plays a role in serotonin clearance and influences mood and behavior. Serotonin 94-103 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 26-30 12444499-0 2002 Differential characteristics of endogenous serotonin-mediated synaptic transmission in the hippocampal CA1 and CA3 fields of anaesthetized rats. Serotonin 43-52 carbonic anhydrase 1 Rattus norvegicus 103-106 23982114-8 2014 ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam. Serotonin 150-159 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 17-22 23982114-9 2014 The half maximal inhibitory concentrations of mOCT3 and hOCT3 for TPA(+), serotonin, diazepam, and ketamine are significantly different. Serotonin 74-83 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 46-51 23319000-6 2014 A post hoc analysis of loci significantly associated with psychiatric disorders suggested that genetic variation at CSMD1, a schizophrenia susceptibility locus, plays a role in the ratio between dopamine and serotonin metabolites in CSF. Serotonin 208-217 CUB and Sushi multiple domains 1 Homo sapiens 116-121 12370375-7 2002 IL-4C and IL-13 increased mucosal permeability, decreased glucose absorption, and decreased chloride secretion in response to 5-hydroxytryptamine. Serotonin 126-145 interleukin 4 Mus musculus 0-5 12149253-6 2002 Application of serotonin or 5-HT(1A) agonists to PFC slices reduced CaMKII activity and the phosphorylation of AMPA receptor subunit GluR1 at the CaMKII site in a PP1-dependent manner. Serotonin 15-24 calcium/calmodulin-dependent protein kinase II alpha Mus musculus 68-74 12149253-6 2002 Application of serotonin or 5-HT(1A) agonists to PFC slices reduced CaMKII activity and the phosphorylation of AMPA receptor subunit GluR1 at the CaMKII site in a PP1-dependent manner. Serotonin 15-24 calcium/calmodulin-dependent protein kinase II alpha Mus musculus 146-152 12149253-7 2002 We concluded that serotonin, by activating 5-HT(1A) receptors, suppress glutamatergic signaling through the inhibition of CaMKII, which is achieved by the inhibition of PKA and ensuing activation of PP1. Serotonin 18-27 calcium/calmodulin-dependent protein kinase II alpha Mus musculus 122-128 24337875-1 2014 RATIONALE: Serotonin (5-HT) neurotransmission is intimately linked to anxiety and depression and a diverse body of evidence supports the involvement of the main inhibitory serotonergic receptor, the serotonin-1A (5-HT(1A)) subtype, in both disorders. Serotonin 11-20 5-hydroxytryptamine receptor 1A Homo sapiens 213-220 12225691-1 2002 It has been proposed that antidepressant effects of neurokinin NK(1) receptor blockade may result from an increase in serotonin (5-HT) transmission. Serotonin 118-127 tachykinin receptor 1 Rattus norvegicus 63-77 24144647-8 2014 Chronic hypoxia caused significant increase in serotonin-induced vasoconstriction; the augmented vasoreactivity was attenuated in Trpc1(-/-) and eliminated in Trpc6(-/-) PAs. Serotonin 47-56 transient receptor potential cation channel, subfamily C, member 1 Mus musculus 130-135 12185402-1 2002 RATIONALE: 5-Hydroxytryptamine(1A) (5-HT(1A)) receptor function has been shown to be attenuated by corticosteroid hormones in a variety of animal experimental paradigms. Serotonin 11-30 5-hydroxytryptamine receptor 1A Homo sapiens 36-54 12107377-4 2002 Among the most detailed mediators studied are corticotropin-releasing factor and serotonin which, via the hypothalamic-pituitary-adrenal axis and the sympathetic and parasympathetic nervous system, stimulate catecholamines and cortisol and inhibit anabolic hormones, insulin, leptin, ghrelin, including neuropeptide Y and other neuropeptides, among them the paracrine-acting cytokines. Serotonin 81-90 leptin Homo sapiens 276-282 24367510-7 2013 Since BDNF/serotonin and CREB signaling could orchestrate a positive feedback loop, our findings suggest that the induction of oxidative stress, reduction of BDNF and serotonin expression, and attenuation of CREB signaling induced by prenatal exposure to supra-therapeutic dose of buprenorphine provide evidence of potential mechanism for the development of depression-like neurobehavior. Serotonin 167-176 cAMP responsive element binding protein 1 Rattus norvegicus 25-29 12122466-4 2002 Intraperitoneal treatment with bovine insulin (4 mg kg(-1)) decreased the 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio in hypothalamus after 1 h. Intraperitoneal administration of fenfluramine (3 mg kg(-1)) caused a depression in food intake coincident with a significant decrease of the hypothalamic 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio. Serotonin 101-120 insulin Bos taurus 38-45 12122466-4 2002 Intraperitoneal treatment with bovine insulin (4 mg kg(-1)) decreased the 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio in hypothalamus after 1 h. Intraperitoneal administration of fenfluramine (3 mg kg(-1)) caused a depression in food intake coincident with a significant decrease of the hypothalamic 5-hydroxyindoleacetic acid/5-hydroxytryptamine ratio. Serotonin 336-355 insulin Bos taurus 38-45 23770339-5 2013 Aprepitant (10 mg/kg) augmented the serotonin elevation produced by fluoxetine (1 or 10 mg/kg) in the gerbil prefrontal cortex; i.e. NK1R antagonism can modulate serotonin responses. Serotonin 36-45 tachykinin receptor 1 Homo sapiens 133-137 11979502-4 2002 Enzymic activity was measured with a radiochemical method using serotonin and beta-phenylethylamine as preferential substrates for MAO A and MAO B, respectively. Serotonin 64-73 monoamine oxidase B Gallus gallus 141-146 12110114-0 2002 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Serotonin 0-19 FBJ osteosarcoma oncogene Mus musculus 89-94 23770339-5 2013 Aprepitant (10 mg/kg) augmented the serotonin elevation produced by fluoxetine (1 or 10 mg/kg) in the gerbil prefrontal cortex; i.e. NK1R antagonism can modulate serotonin responses. Serotonin 162-171 tachykinin receptor 1 Homo sapiens 133-137 24205443-2 2013 In drug-free patients, CSF levels of the metabolites of noradrenaline (MHPG), serotonin (5-HIAA), and dopamine (HVA), neurotransmitters involved in eating behavior, were estimated in searching for associations with body mass index (BMI). Serotonin 78-87 colony stimulating factor 2 Homo sapiens 23-26 12015221-0 2002 Immunolocalization of semicarbazide-sensitive amine oxidase in human dental pulp and its activity towards serotonin. Serotonin 106-115 amine oxidase copper containing 2 Homo sapiens 22-59 23719069-1 2013 This study evaluated the effect of a one month 17beta-estradiol treatment on brain serotonin (5-HT) reuptake transporter (SERT) in long-term ovariectomized (OVX) female monkeys (Macaca fascicularis) bearing a unilateral lesion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injected directly into the left substantia nigra modeling Parkinson disease (PD). Serotonin 83-92 sodium-dependent serotonin transporter Macaca fascicularis 122-126 12015221-1 2002 The semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) from crude homogenates of human dental pulp was shown to catalyse the oxidative deamination of 5-hydroxytryptamine (serotonin; 5-HT) with a K(m) of 318+/-52 microM. Serotonin 156-175 amine oxidase copper containing 2 Homo sapiens 4-41 12015221-1 2002 The semicarbazide-sensitive amine oxidase (EC 1.4.3.6; SSAO) from crude homogenates of human dental pulp was shown to catalyse the oxidative deamination of 5-hydroxytryptamine (serotonin; 5-HT) with a K(m) of 318+/-52 microM. Serotonin 156-175 amine oxidase copper containing 2 Homo sapiens 55-59 23633214-12 2013 In controls, whole-blood serotonin was positively correlated with osteocalcin, PINP, and CTX (R values = 0.40-0.47, all P < .05.). Serotonin 25-34 cytochrome P450 family 27 subfamily A member 1 Homo sapiens 89-92 11852052-0 2002 Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents. Serotonin 36-45 potassium voltage-gated channel subfamily H member 2 Homo sapiens 80-84 11852052-1 2002 Using whole-cell patch clamp recording of heterologous HERG-mediated currents in transfected mammalian cells, we observed that the selective serotonin re-uptake inhibitor citalopram blocks HERG with an IC(50) of 3.97 microM. Serotonin 141-150 potassium voltage-gated channel subfamily H member 2 Homo sapiens 55-59 11852052-1 2002 Using whole-cell patch clamp recording of heterologous HERG-mediated currents in transfected mammalian cells, we observed that the selective serotonin re-uptake inhibitor citalopram blocks HERG with an IC(50) of 3.97 microM. Serotonin 141-150 potassium voltage-gated channel subfamily H member 2 Homo sapiens 189-193 23499801-4 2013 Reg IV showed cellular co-distribution with serotonin and chromogranin A in all parts of GI-tract. Serotonin 44-53 regenerating family member 4 Homo sapiens 0-6 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Serotonin 130-139 monoamine oxidase A Homo sapiens 0-19 12140786-1 2002 Monoamine oxidase A (MAO A) is located on the X chromosome and metabolizes biogenic amines including dopamine, norepinephrine and serotonin. Serotonin 130-139 monoamine oxidase A Homo sapiens 21-26 23665899-2 2013 Tryptophan hydroxylase-1 (TPH1) is a key enzyme of serotonin synthesis. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 0-24 11927162-0 2002 Selective innervation of lamina I projection neurones that possess the neurokinin 1 receptor by serotonin-containing axons in the rat spinal cord. Serotonin 96-105 tachykinin receptor 1 Rattus norvegicus 71-92 23665899-2 2013 Tryptophan hydroxylase-1 (TPH1) is a key enzyme of serotonin synthesis. Serotonin 51-60 tryptophan hydroxylase 1 Homo sapiens 26-30 23333373-5 2013 The rs6295 G-/C-allelic variant is located in the promoter region of the human HTR1a gene, encoding the G-protein-coupled receptor for 5-hydroxytryptamine (5HT1AR). Serotonin 135-154 5-hydroxytryptamine receptor 1A Homo sapiens 79-84 11150894-1 2001 It is a fairly well-known fact that the CSF collection time (tapping time) at lumbar puncture may influence CSF levels of monoamine compounds (e.g. the serotonin metabolite 5-hydroxyindoleacetic acid, 5-HIAA) and some neuropeptides. Serotonin 152-161 colony stimulating factor 2 Homo sapiens 40-43 11150894-1 2001 It is a fairly well-known fact that the CSF collection time (tapping time) at lumbar puncture may influence CSF levels of monoamine compounds (e.g. the serotonin metabolite 5-hydroxyindoleacetic acid, 5-HIAA) and some neuropeptides. Serotonin 152-161 colony stimulating factor 2 Homo sapiens 108-111 23408467-11 2013 PTSD and MDD have in common an upregulation of 5-HT1A binding including midbrain autoreceptors that would favor less firing and serotonin release. Serotonin 128-137 5-hydroxytryptamine receptor 1A Homo sapiens 47-53 11842879-8 2001 Serotonin application resulted in a significant increase in the frequency of mIPSCs in CA1 pyramidal cells but there was no significant difference between cells from the two nutritional groups in the characteristics of this effect. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 87-90 11732903-0 2001 Loss of serotonin oxidation as a component of the altered substrate specificity in the Y444F mutant of recombinant human liver MAO A. Serotonin 8-17 monoamine oxidase A Homo sapiens 127-132 23180809-0 2013 Increasing brain serotonin corrects CO2 chemosensitivity in methyl-CpG-binding protein 2 (Mecp2)-deficient mice. Serotonin 17-26 methyl CpG binding protein 2 Mus musculus 60-88 11732903-6 2001 Y444F MAO A oxidizes kynuramine with a k(cat) <2% of WT enzyme and is greater than 100-fold slower in catalyzing the oxidation of phenylethylamine or of serotonin. Serotonin 156-165 monoamine oxidase A Homo sapiens 6-11 11732903-10 2001 These data show that mutation of Y444F in MAO A results in a mutant that has lost its ability to efficiently oxidize serotonin (its physiological substrate) but, however, exhibits unaltered quantitative structure-activity parameters in the binding and rate of benzylamine analogues. Serotonin 117-126 monoamine oxidase A Homo sapiens 42-47 11011048-0 2000 Serum leptin levels after central and systemic injection of a serotonin precursor, 5-hydroxytryptophan, in mice. Serotonin 62-71 leptin Mus musculus 6-12 11011048-1 2000 Effects of peripheral and central injections of a serotonin (5-hydroxytryptamine, 5-HT) precursor, 5-hydroxytryptophan (5-HTP), on serum leptin levels were studied in mice. Serotonin 61-80 leptin Mus musculus 137-143 11704418-5 2001 The serotonin system, and the serotonin(1A) (5-HT(1A)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-HT(1A) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 204-221 23180809-0 2013 Increasing brain serotonin corrects CO2 chemosensitivity in methyl-CpG-binding protein 2 (Mecp2)-deficient mice. Serotonin 17-26 methyl CpG binding protein 2 Mus musculus 90-95 11704418-5 2001 The serotonin system, and the serotonin(1A) (5-HT(1A)) receptor in particular, have been under intense investigation, mostly due to the fact that serotonergic drugs that directly or indirectly affect the 5-HT(1A) receptor, are effective therapeutic agents in treating patients with various neuropsychiatric disorders, including anxiety and depression. Serotonin 30-39 5-hydroxytryptamine receptor 1A Homo sapiens 204-221 10941137-1 2000 Serotonin 5-HT(1A) receptor antagonists potentiate the effects of serotonin reuptake inhibitors on extracellular serotonin levels in a variety of brain regions. Serotonin 66-75 5-hydroxytryptamine receptor 1A Homo sapiens 10-27 23180809-2 2013 In addition, patients with Rett syndrome and male mice that are null for Mecp2 show reduced levels of brain serotonin (5-HT). Serotonin 108-117 methyl CpG binding protein 2 Mus musculus 73-78 23585722-0 2013 Effects of serotonin on erythropoietin expression in mouse hippocampus. Serotonin 11-20 erythropoietin Mus musculus 24-38 10964974-9 2000 The neurochemical evaluation of the eNOS-/- mice revealed increases in the concentrations of the serotonin metabolite 5-HIAA in the cerebellum, together with an accelerated serotonin turnover in the frontal cortex. Serotonin 97-106 nitric oxide synthase 3, endothelial cell Mus musculus 36-43 10964974-9 2000 The neurochemical evaluation of the eNOS-/- mice revealed increases in the concentrations of the serotonin metabolite 5-HIAA in the cerebellum, together with an accelerated serotonin turnover in the frontal cortex. Serotonin 173-182 nitric oxide synthase 3, endothelial cell Mus musculus 36-43 10998536-2 2000 Nociceptin inhibits the electrically or K(+)-evoked noradrenaline, dopamine, serotonin, and glutamate release in brain slices from guinea-pig, rat, and mouse. Serotonin 77-86 prepronociceptin Rattus norvegicus 0-10 11750182-12 2001 Less feedback inhibition of serotonin DRN firing via 5-HT(1A) autoreceptors and enhancement of serotonin action due to less uptake of serotonin, is consistent with compensatory changes in response to hypofunction in depressed suicides. Serotonin 28-37 5-hydroxytryptamine receptor 1A Homo sapiens 53-60 23407616-0 2013 Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Serotonin 89-98 solute carrier family 29 member 4 Homo sapiens 48-85 11689160-6 2001 METH produced a significant decrease in striatal dopamine level, reaching a very low level after 24 h. Striatal serotonin level significantly increased and returned to control levels after 2 h. These data show that METH induced egr-1 and c-fos mRNA expression in selective brain areas, which correlated with an alteration in monoamines. Serotonin 112-121 early growth response 1 Mus musculus 228-233 10831475-2 2000 Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. Serotonin 246-255 monoamine oxidase A Homo sapiens 175-194 10831475-2 2000 Given the link between abnormalities in serotonergic neurotransmission and bipolar disorder, a candidate gene association approach was applied to study the involvement of the monoamine oxidase A (MAOA) gene, which codes for a catabolic enzyme of serotonin, in the susceptibility to bipolar disorder. Serotonin 246-255 monoamine oxidase A Homo sapiens 196-200 23392679-3 2013 However, a significant 5-HTTLPR effect on receptor binding at the 5-HT(1A) receptor site has been reported in humans, suggesting the 5-HTTLPR polymorphism may play a role in serotonin (5-HT) function. Serotonin 174-183 5-hydroxytryptamine receptor 1A Homo sapiens 66-83 10942111-1 2000 Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space. Serotonin 233-252 solute carrier family 22 member 2 Homo sapiens 42-46 10942111-1 2000 Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space. Serotonin 233-252 IL2 inducible T cell kinase Homo sapiens 52-55 11679052-5 2001 FG-labelled serotonin neurones expressed ERbeta mRNA in the DRN, and the number of the serotonin neurones containing ERbeta mRNA between the OVX-group and the E2-treated group was not significantly different. Serotonin 12-21 estrogen receptor 2 Rattus norvegicus 41-47 11679052-5 2001 FG-labelled serotonin neurones expressed ERbeta mRNA in the DRN, and the number of the serotonin neurones containing ERbeta mRNA between the OVX-group and the E2-treated group was not significantly different. Serotonin 87-96 estrogen receptor 2 Rattus norvegicus 117-123 23531214-9 2013 In this context, the antioxidant suppression of leptin release and Th1-type activity is beneficial to increase serotonin and melatonin levels. Serotonin 111-120 leptin Mus musculus 48-54 11590969-1 2001 The alpha-methyl-L-trypotophan (alpha-MTrp) method for the study of the brain serotonergic system is based on the fact that labelled alpha-MTrp is taken up by and, in part, retained in the brain, and this retention (trapping) is proportional to brain serotonin (5-HT) synthesis. Serotonin 251-260 lysosomal protein transmembrane 4 alpha Homo sapiens 38-42 10807682-0 2000 Modulation of 5-hydroxytryptamine efflux from rat cortical synaptosomes by opioids and nociceptin. Serotonin 14-33 prepronociceptin Rattus norvegicus 87-97 24092348-7 2013 Serotonin is contained in platelets but is also synthesized by pulmonary endothelial cells which express tryptophan hydroxylase 1, the rate-limiting enzyme of 5-HT synthesis. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 105-129 10817615-2 2000 The present study aimed to determine the effect of the selective non-peptide rat neurokinin-1 (NK1) receptor antagonists WIN 51,708 and CP-96,345 on the firing activity of rat dorsal raphe serotonin (5-HT) and locus coeruleus noradrenaline (NA) neurons. Serotonin 189-198 tachykinin receptor 1 Rattus norvegicus 81-108 11487610-0 2001 Mutations in the Caenorhabditis elegans serotonin reuptake transporter MOD-5 reveal serotonin-dependent and -independent activities of fluoxetine. Serotonin 40-49 Transporter Caenorhabditis elegans 71-76 22962332-10 2012 However, the mutant SNAP-25 could no longer support 5-hydroxytryptamine-mediated inhibition of exocytosis. Serotonin 52-71 synaptosome associated protein 25 Homo sapiens 20-27 11432998-0 2001 Selective inhibition of local excitatory synaptic transmission by serotonin through an unconventional receptor in the CA1 region of rat hippocampus. Serotonin 66-75 carbonic anhydrase 1 Rattus norvegicus 118-121 11268009-1 2001 Cutaneous antidromic vasodilatation and plasma extravasation, two phenomena that occur in neurogenic inflammation, are partially blocked by substance P (SP) receptor antagonists and are known to be mediated in part by mast cell-released substances, such as histamine, serotonin, and nitric oxide. Serotonin 268-277 tachykinin receptor 1 Rattus norvegicus 140-165 10737591-8 2000 These results suggest that the mechanism by which d-fenfluramine induces c-fos and jun B expression in the rat caudoputamen depends at least in part on activation of the dopaminergic system by serotonin. Serotonin 193-202 JunB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 83-88 22955057-0 2012 RhoA localization with caveolin-1 regulates vascular contractions to serotonin. Serotonin 69-78 caveolin 1, caveolae protein Mus musculus 23-33 10665620-2 2000 The aim of the present study was to use positron emission tomography with the selective 5-HT1A receptor antagonist [11C]WAY-100635 to measure 5-HT1A receptor binding in depressed patients before and during treatment with selective serotonin reuptake inhibitors. Serotonin 231-240 5-hydroxytryptamine receptor 1A Homo sapiens 142-157 10729753-5 2000 These findings suggest that the higher plasma-free serotonin levels observed in severe pre-eclampsia are mainly due to a reduction in MAO-A activity and not limited by the rate of serotonin uptake into the cells. Serotonin 51-60 monoamine oxidase A Homo sapiens 134-139 11332694-7 2001 In antrum, substance P immunoreactivity was found exclusively in serotonin-IR cells. Serotonin 65-74 tachykinin 1 Mus musculus 11-22 11332694-11 2001 The proportion of serotonin-IR cells showing substance P-immuno-reactivity was decreased in both diabetic models, thus indicating a shut-off of substance P-gene expression. Serotonin 18-27 tachykinin 1 Mus musculus 45-56 22955057-6 2012 RhoA-dependent contractions in response to serotonin were markedly augmented in arteries from cav-1 KO mice despite a modest reduction in rhoA expression compared with WT. Serotonin 43-52 caveolin 1, caveolae protein Mus musculus 94-99 23008335-2 2012 Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses the conversion of tryptophan to serotonin and exhausts tryptophan, is a potent regulator of immunity. Serotonin 131-140 tryptophan hydroxylase 1 Homo sapiens 38-43 11332694-11 2001 The proportion of serotonin-IR cells showing substance P-immuno-reactivity was decreased in both diabetic models, thus indicating a shut-off of substance P-gene expression. Serotonin 18-27 tachykinin 1 Mus musculus 144-155 23531135-6 2000 Inhibitors of MAO A are clinically useful to treat anxiety and depression since they are expected to increase both noradrenalin and serotonin levels in the brain. Serotonin 132-141 monoamine oxidase A Homo sapiens 14-19 23008335-2 2012 Here we report the novel finding that Tph-1 (tryptophan hydroxylase-1), a synthase which catalyses the conversion of tryptophan to serotonin and exhausts tryptophan, is a potent regulator of immunity. Serotonin 131-140 tryptophan hydroxylase 1 Homo sapiens 45-69 11332694-14 2001 However, pre-diabetic NOD mice showed a decreased proportion of substance P in serotonin-IR cells, which might be explained by the increased number of serotonin-IR cells, combined with an unchanged number of substance P-IR cells. Serotonin 79-88 tachykinin 1 Mus musculus 64-75 11332694-14 2001 However, pre-diabetic NOD mice showed a decreased proportion of substance P in serotonin-IR cells, which might be explained by the increased number of serotonin-IR cells, combined with an unchanged number of substance P-IR cells. Serotonin 151-160 tachykinin 1 Mus musculus 64-75 22534195-5 2012 Most of the literature supports the idea that leptin suppresses bone mass by acting in the brainstem to reduce serotonin-dependent sympathetic signaling from the ventromedial hypothalamus to bone. Serotonin 111-120 leptin Homo sapiens 46-52 11332694-15 2001 In conclusion, diabetic animal models of both type 1 and type 2 appear to have a combination of decreased expression of substance P in serotonin-IR cells of both antrum and duodenum, as well as a change in the number of mono-expressed cells. Serotonin 135-144 tachykinin 1 Mus musculus 120-131 11277981-5 2001 We hypothesized that dexamethasone, corticosterone and serotonin exposure modify GR and MR mRNA levels in fetal mouse hippocampal cultures, and that these effects are confined to neurons. Serotonin 55-64 nuclear receptor subfamily 3, group C, member 2 Mus musculus 88-90 10457081-0 1999 Serotonin via 5-HT1B and 5-HT2B receptors stimulates anion secretion in the rat epididymal epithelium. Serotonin 0-9 5-hydroxytryptamine receptor 2B Rattus norvegicus 25-31 10498859-12 1999 The effects of serotonin on field potential responses were mimicked by 5-HT1A-receptor agonists (8-OH-DPAT, 5-CT) and partially prevented by the 5-HT1A-receptor antagonist (S-UH-301). Serotonin 15-24 5-hydroxytryptamine receptor 1A Homo sapiens 71-86 22819790-1 2012 The aim of this study was to determine whether intrauterine malnutrition (IUM) produces a change in the expression of tryptophan-5-hydroxylase (TPH) 1 and/or 2 as the primary mechanism to explain the observed chronic cerebral acceleration of the synthesis of 5-hydroxytryptamine (5-HT). Serotonin 259-278 tryptophan hydroxylase 1 Homo sapiens 118-150 10498859-12 1999 The effects of serotonin on field potential responses were mimicked by 5-HT1A-receptor agonists (8-OH-DPAT, 5-CT) and partially prevented by the 5-HT1A-receptor antagonist (S-UH-301). Serotonin 15-24 5-hydroxytryptamine receptor 1A Homo sapiens 145-160 10510173-0 1999 Action of serotonin on the hyperpolarization-activated cation current (Ih) in rat CA1 hippocampal neurons. Serotonin 10-19 carbonic anhydrase 1 Rattus norvegicus 82-85 11320658-4 2001 Our studies showed that IFN-gamma enhanced 5-hydroxytryptamine (5-HT) content (measured by high-performance liquid chromatography, HPLC) and increased pinealocyte process length in pineal cultures. Serotonin 43-62 interferon gamma Rattus norvegicus 24-33 10510173-1 1999 We studied the effects of serotonin (5-HT) on hippocampal CA1 pyramidal neurons. Serotonin 26-35 carbonic anhydrase 1 Rattus norvegicus 58-61 22945629-0 2012 FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. Serotonin 64-73 forkhead box O1 Mus musculus 0-5 11202445-1 2001 The 5-HT1A subtype of receptors for the neurotransmitter serotonin is predominantly located in the limbic forebrain and is involved in the modulation of emotion and the function of the hypothalamus. Serotonin 57-66 5-hydroxytryptamine receptor 1A Homo sapiens 4-10 22945629-4 2012 We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element-binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4). Serotonin 105-114 forkhead box O1 Mus musculus 39-44 22945629-4 2012 We found that the transcription factor FOXO1 is a crucial determinant of the effects of duodenum-derived serotonin on bone formation We identified two key FOXO1 complexes in osteoblasts, one with the transcription factor cAMP-responsive element-binding protein 1 (CREB) and another with activating transcription factor 4 (ATF4). Serotonin 105-114 forkhead box O1 Mus musculus 155-160 11125028-6 2001 The substrate selectivity of dDAT parallels that of the mammalian DATs in that dopamine and tyramine are the preferred substrates, whereas octopamine is transported less efficiently, and serotonin not at all. Serotonin 187-196 Dopamine transporter Drosophila melanogaster 29-33 22945629-5 2012 Under normal levels of circulating serotonin, the proliferative activity of FOXO1 was promoted by a balance between its interaction with CREB and ATF4. Serotonin 35-44 forkhead box O1 Mus musculus 76-81 10400249-1 1999 Recent studies have shown that behavioral and neurochemical changes induced by selective serotonin (5-HT) reuptake inhibitors such as fluoxetine are potentiated by coadministration of a 5-HT1A receptor antagonist. Serotonin 89-98 5-hydroxytryptamine receptor 1A Homo sapiens 186-201 22945629-6 2012 However, high circulating serotonin levels prevented the association of FOXO1 with CREB, resulting in suppressed osteoblast proliferation. Serotonin 26-35 forkhead box O1 Mus musculus 72-77 11301215-0 2001 Bi-directional modulation of 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint by nociceptin. Serotonin 29-48 prepronociceptin Rattus norvegicus 103-113 22945629-7 2012 These observations identify FOXO1 as the molecular node of an intricate transcriptional machinery that confers the signal of duodenal-derived serotonin to inhibit bone formation. Serotonin 142-151 forkhead box O1 Mus musculus 28-33 11301215-3 2001 The present study investigates the effect of nociceptin on synovial plasma extravasation and its ability to modulate 5-hydroxytryptamine-induced synovial plasma extravasation using the rat knee joint model of inflammation. Serotonin 117-136 prepronociceptin Rattus norvegicus 45-55 11301215-5 2001 Nociceptin at concentrations up to 1 nM enhances 5-hydroxytryptamine-induced synovial plasma extravasation (up to 50%) and nociceptin at concentrations above 100 nM inhibits 5-hydroxytryptamine-induced synovial plasma extravasation (down to 45%). Serotonin 49-68 prepronociceptin Rattus norvegicus 0-10 11301215-5 2001 Nociceptin at concentrations up to 1 nM enhances 5-hydroxytryptamine-induced synovial plasma extravasation (up to 50%) and nociceptin at concentrations above 100 nM inhibits 5-hydroxytryptamine-induced synovial plasma extravasation (down to 45%). Serotonin 174-193 prepronociceptin Rattus norvegicus 123-133 10224140-10 1999 Acidic metabolites of neurotransmitters derived from dopamine, epinephrine, norepinephrine, and serotonin inhibited the uptake of estrone sulfate via OAT3. Serotonin 96-105 solute carrier family 22 member 8 Rattus norvegicus 150-154 22906985-2 2012 Monoamine oxidase A (MAOA), the degradation enzyme of serotonin and dopamine, is suppressed in cholangiocarcinoma via an unknown mechanism. Serotonin 54-63 monoamine oxidase A Homo sapiens 0-19 10188955-6 1999 Input to sensory neurons from L16 can be altered by two neuromodulators of the reflex, the small cardioactive peptide and serotonin. Serotonin 122-131 immunoglobulin kappa variable 3D-15 Homo sapiens 30-33 10188955-8 1999 Part of the effect of serotonin on the transmission between L16 and the sensory neurons is due to a postsynaptic mechanism, since responses to acetylcholine application in these cells are decreased by serotonin. Serotonin 22-31 immunoglobulin kappa variable 3D-15 Homo sapiens 60-63 10188955-8 1999 Part of the effect of serotonin on the transmission between L16 and the sensory neurons is due to a postsynaptic mechanism, since responses to acetylcholine application in these cells are decreased by serotonin. Serotonin 201-210 immunoglobulin kappa variable 3D-15 Homo sapiens 60-63 22906985-2 2012 Monoamine oxidase A (MAOA), the degradation enzyme of serotonin and dopamine, is suppressed in cholangiocarcinoma via an unknown mechanism. Serotonin 54-63 monoamine oxidase A Homo sapiens 21-25 23035305-2 2004 The human H3R gene is located on chromosome 20q13.33, and its products are expressed predominantly in the basal ganglia, hippocampus, and cortical areas, which participate in the synthesis and release of neurotransmitters (e.g., acetylcholine, dopamine, serotonin, and noradrenaline) from histaminergic neurons (2-4). Serotonin 254-263 histamine receptor H3 Homo sapiens 10-13 10085157-1 1999 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT, EC 2.3.1.87) is the first enzyme in the conversion of serotonin to melatonin. Serotonin 128-137 aralkylamine N-acetyltransferase Gallus gallus 67-72 10085157-7 1999 The pike AANAT-1 and AANAT-2 enzymes (66% identical amino acids) exhibit marked differences in their affinity for serotonin, relative affinity for indoleethylamines versus phenylethylamines and temperature-activity relationships. Serotonin 114-123 aralkylamine N-acetyltransferase Gallus gallus 9-14 10085157-7 1999 The pike AANAT-1 and AANAT-2 enzymes (66% identical amino acids) exhibit marked differences in their affinity for serotonin, relative affinity for indoleethylamines versus phenylethylamines and temperature-activity relationships. Serotonin 114-123 aralkylamine N-acetyltransferase Gallus gallus 21-26 11063979-1 2000 Preclinical studies suggest that augmentation of selective serotonin (5-HT) reuptake inhibitors by the 5-HT(1A) receptor agent pindolol might reduce the delay between initiation of treatment and antidepressant response, an effect largely mediated by blockade of 5-HT(1A) autoreceptors in the dorsal raphe nuclei. Serotonin 59-68 5-hydroxytryptamine receptor 1A Homo sapiens 103-120 11063979-1 2000 Preclinical studies suggest that augmentation of selective serotonin (5-HT) reuptake inhibitors by the 5-HT(1A) receptor agent pindolol might reduce the delay between initiation of treatment and antidepressant response, an effect largely mediated by blockade of 5-HT(1A) autoreceptors in the dorsal raphe nuclei. Serotonin 59-68 5-hydroxytryptamine receptor 1A Homo sapiens 103-110 22774769-2 2012 In the marine mollusk, Aplysia californica, an increase in phosphorylation of the novel PKC, Apl II, at the hydrophobic site is associated with a protein synthesis-dependent increase in synaptic strength seen after continuous application of serotonin. Serotonin 241-250 calcium-independent protein kinase C Aplysia californica 93-99 10915831-4 2000 We investigated the effects of Na(+) on the intrinsic activity of 5-hydroxytryptamine(1A) (5-HT(1A)) receptor ligands, measured as maximal effect (E(MAX)), using guanosine 5"-0-(3-[35S]thio)-triphosphate ([35S]GTPgammaS) binding to membranes prepared from human epithelioid carcinoma (HeLa) cells, expressing 500 fmol/mg protein of cloned human 5-HT(1A) receptor (HA7 cells). Serotonin 66-85 5-hydroxytryptamine receptor 1A Homo sapiens 91-109 10826917-8 2000 Other MPO systems inactivating LADH were (a) MPO/H2O2/chlorpromazine; (b) MPO/H2O2/monophenolic systems, including L-tyrosine, serotonin and acetaminophen and (c) MPO/H2O2/di- and polyphenolic systems, including norepinephrine, catechol, nordihydroguaiaretic acid, caffeic acid, quercetin and catechin. Serotonin 127-136 myeloperoxidase Sus scrofa 6-9 22774769-6 2012 Continuous application of serotonin increased phosphorylation of PKC Apl II at the hydrophobic site in cultured sensory neurons, and this was blocked by Torin, which inhibits both TORC1 and TORC2. Serotonin 26-35 calcium-independent protein kinase C Aplysia californica 69-75 10063483-1 1999 The reversible inhibitors of monoamine oxidase type A (RIMAs) are a newer group of antidepressants that have had much less impact on clinical psychopharmacology than another contemporary class of medications, the selective serotonin reuptake-inhibitors (SSRIs). Serotonin 223-232 monoamine oxidase A Homo sapiens 29-53 22929065-1 2012 OBJECTIVE: To examine whether the activation of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in serotonin production, is associated with depressive symptoms. Serotonin 105-114 indoleamine 2,3-dioxygenase 1 Homo sapiens 77-80 9988712-2 1999 The Gi-coupled serotonin (5-hydroxytryptamine (5-HT)) 5-HT1A receptor, heterologously expressed in Chinese hamster ovary or human embryonic kidney 293 cells, mediated rapid activation of Erk1/2 via a mechanism dependent upon both Ras activation and clathrin-mediated endocytosis. Serotonin 15-24 5-hydroxytryptamine receptor 1A Homo sapiens 54-69 10962249-5 2000 There are also needs for other types of 5-HT(1A) receptor radioligands, for example, ligands sensitive to elevated serotonin levels, ligands labelled with longer-lived fluorine-18 for distribution to "satellite" PET centres, and ligands labelled with iodine-123 for single photon emission computerised tomography (SPECT) imaging. Serotonin 115-124 5-hydroxytryptamine receptor 1A Homo sapiens 40-57 10962254-2 2000 is a positron-emission tomography (PET) radioligand for in vivo imaging of the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor. Serotonin 79-98 5-hydroxytryptamine receptor 1A Homo sapiens 104-122 10962256-1 2000 In several positron-emission tomography studies of human subjects, analyses of data from the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor radioligand, [(11)C]WAY-100635 ? Serotonin 93-112 5-hydroxytryptamine receptor 1A Homo sapiens 118-136 10962258-1 2000 Regional 5-hydroxytryptamine(1A) (5-HT(1A)) receptor binding potential (BP) of depressed subjects with primary, recurrent, familial mood disorders was compared to that of healthy controls by using positron emission tomography and [carbonyl-(11)C]WAY-100635 ?[(11)C]N-(2-(4-(2-methoxyphenyl)-1-piperazin-1-yl)ethyl)-N-(2- pyridy l)cyclohexanecarboxamide?. Serotonin 9-28 5-hydroxytryptamine receptor 1A Homo sapiens 34-52 10962261-1 2000 Preclinical studies in rodents suggest that augmentation of serotonin reuptake inhibitors (SSRIs) therapy by the 5-hydroxytryptamine(1A) (5-HT(1A)) receptor agent pindolol might reduce the delay between initiation of treatment and antidepressant response. Serotonin 113-132 5-hydroxytryptamine receptor 1A Homo sapiens 138-156 10962261-2 2000 This hypothesis is based on the ability of pindolol to potentiate the increase in serotonin (5-HT) transmission induced by SSRIs, an effect achieved by blockade of the 5-HT(1A) autoreceptors in the dorsal raphe nuclei (DRN). Serotonin 82-91 5-hydroxytryptamine receptor 1A Homo sapiens 168-175 10721046-5 1999 By inference, we conclude that interleukin-1 induced anorexia is mediated by at least two different mechanism: i) interleukin-1 direct action within the hypothalamus; ii) increased brain serotonergic activity, secondary to interleukin-1 induced increased brain availability of the serotonin precursor, tryptophan. Serotonin 281-290 interleukin 1 alpha Homo sapiens 31-44 10197774-2 1999 At embryonic day 14, saturating concentrations of brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4 and basic fibroblast growth factor elicited a two- to 2.5-fold increase in numbers of tryptophan hydroxylase- and serotonin-immunoreactive neurons over a four-day culture period. Serotonin 230-239 neurotrophin 3 Rattus norvegicus 85-99 22607670-1 2012 It is suggested that the ratio of dopamine D(2) to 5-hydroxytryptamine 5-HT(1A) activity is an important parameter that determines the efficiency of antipsychotic drugs. Serotonin 51-70 5-hydroxytryptamine receptor 1A Homo sapiens 71-78 9868741-1 1998 The selective serotonin re-uptake inhibitor, fluvoxamine, is a very potent inhibitor of CYP1A2, and accordingly causes pharmacokinetic interactions with drugs metabolised by CYP1A2, such as caffeine, theophylline, imipramine, tacrine and clozapine. Serotonin 14-23 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 88-94 22919723-1 2012 Compounds with serotonin reuptake inhibition/5-HT(1A) dual activity were used to build 3D pharmacophore model as a training molecules by Discover Studio. Serotonin 15-24 5-hydroxytryptamine receptor 1A Homo sapiens 45-52 9868741-1 1998 The selective serotonin re-uptake inhibitor, fluvoxamine, is a very potent inhibitor of CYP1A2, and accordingly causes pharmacokinetic interactions with drugs metabolised by CYP1A2, such as caffeine, theophylline, imipramine, tacrine and clozapine. Serotonin 14-23 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 174-180 9771557-6 1998 T-2 treatment increased 5-hydroxy-3-indoleacetic acid and serotonin throughout the brain, and produced a transient increase in norepinephrine in the nucleus raphe magnus and a temporary decrease in the substantia nigra. Serotonin 58-67 brachyury 2 Rattus norvegicus 0-3 10845941-6 2000 In MKs of intermediary maturation stage, granulophysin was mainly localized within dense granules and multivesicular bodies (MVBs), which were also labeled for serotonin. Serotonin 160-169 CD63 molecule Homo sapiens 41-54 10867119-5 2000 The results suggest that MAOA genotypes may participate differentially in the regulation of dopamine and serotonin turnover rates under presumed steady state in the central nervous system. Serotonin 105-114 monoamine oxidase A Homo sapiens 25-29 22357950-9 2012 In addition, heterodimerization is crucially involved in initiation of the serotonin-mediated 5-HT(1A) receptor internalization and also enhances the ability of the 5-HT(1A) receptor to activate the mitogen-activated protein kinases. Serotonin 75-84 5-hydroxytryptamine receptor 1A Homo sapiens 94-111 10760362-2 2000 The neurochemical effects of a novel dopamine (DA) D(2)-like and serotonin (5-HT) 5-HT(1A) agonist, PD 158771, are described. Serotonin 65-74 5-hydroxytryptamine receptor 1A Homo sapiens 82-89 9744926-0 1998 Serotonin reduces polysynaptic inhibition via 5-HT1A receptors in the superficial entorhinal cortex. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 46-52 22357950-9 2012 In addition, heterodimerization is crucially involved in initiation of the serotonin-mediated 5-HT(1A) receptor internalization and also enhances the ability of the 5-HT(1A) receptor to activate the mitogen-activated protein kinases. Serotonin 75-84 5-hydroxytryptamine receptor 1A Homo sapiens 165-182 22454151-8 2012 Kiss1 administration significantly increased the c-fos mRNA levels in the raphe nuclei (2.5-fold, P < 0.001) and genes involved in the regulation of serotonin levels (pet1 and slc6a4a; 3.3- and 2.2-fold, P < 0.01). Serotonin 152-161 KiSS-1 metastasis suppressor Danio rerio 0-5 10876805-3 2000 This mini-review focuses on the issues (1) how the immune system transmits information to the brain and (2) how pro-inflammatory cytokines, interleukin-1 in particular, alter the activities of monoamines (catecholamines and serotonin) and some peptides (CRF, alpha MSH) for the manifestation of acute phase responses. Serotonin 224-233 interleukin 1 alpha Homo sapiens 140-153 22487062-10 2012 Gut-derived Lrp5 has been shown to regulate serotonin synthesis by controlling the production of serotonin rate-limiting enzyme, Tph1. Serotonin 44-53 tryptophan hydroxylase 1 Homo sapiens 129-133 10757762-5 2000 Although flp-1 mutants were sensitive to stimulation of egg-laying by serotonin, the magnitude of their serotonin response was abnormally low. Serotonin 70-79 SQPNFLRF-amide Caenorhabditis elegans 9-14 10757762-5 2000 Although flp-1 mutants were sensitive to stimulation of egg-laying by serotonin, the magnitude of their serotonin response was abnormally low. Serotonin 104-113 SQPNFLRF-amide Caenorhabditis elegans 9-14 9881863-0 1998 5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation. Serotonin 2-19 opioid receptor mu 1 Homo sapiens 116-134 9680375-5 1998 BMCMC in SCF exhibited cytochemical staining properties, protease and histamine content, and increased serotonin uptake consistent with more mature differentiated mast cells as compared with BMCMC in CM or Cl.MC/ C57.1 cells. Serotonin 103-112 kit ligand Mus musculus 9-12 9680375-6 1998 BMCMC in SCF released serotonin, 14C-labeled arachidonic acid metabolites and tumor necrosis factor-alpha (TNF-alpha) on stimulation with MBP, while no response was seen from either BMCMC in CM or Cl.MC/C57.1 cells. Serotonin 22-31 kit ligand Mus musculus 9-12 10685879-7 2000 Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells. Serotonin 58-67 solute carrier family 6 member 2 Rattus norvegicus 82-108 22487062-10 2012 Gut-derived Lrp5 has been shown to regulate serotonin synthesis by controlling the production of serotonin rate-limiting enzyme, Tph1. Serotonin 97-106 tryptophan hydroxylase 1 Homo sapiens 129-133 10685879-7 2000 Procaine also inhibited uptake of norepinephrine (NE) and serotonin (5-HT) by the norepinephrine transporter (NET) or serotonin transporter (SERT) expressed in COS cells. Serotonin 58-67 solute carrier family 6 member 2 Rattus norvegicus 110-113 22068459-3 2012 OBJECTIVES: We provide an overview of the many recent studies that have used SOR to explore the mnemonic effects of manipulation of the key transmitter systems relevant to schizophrenia-the dopamine, glutamate, GABA, acetylcholine, serotonin and cannabinoid systems-alone or in combination. Serotonin 232-241 sorcin Mus musculus 77-80 21430799-6 1999 Fall in the level of serotonin and 5-HIAA in the CSF and in hind brain is found in subjects dying from suicide. Serotonin 21-30 colony stimulating factor 2 Homo sapiens 49-52 9787266-0 1998 Serotonin and carbachol induced suppression of synaptic responses in rat CA1 hippocampal area: effects of corticosteroid receptor activation in vivo. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 73-76 9787266-1 1998 Previous studies have shown that corticosteroids affect the changes in membrane potential evoked in CA1 hippocampal neurons by serotonin and the metabolically stable cholinergic analogue carbachol: Low corticosteroid levels induced by steroid administration to adrenalectomized rats or obtained in adrenally intact rats were associated with small transmitter responses. Serotonin 127-136 carbonic anhydrase 1 Rattus norvegicus 100-103 9787266-5 1998 The data show that the effect of in vivo activation of corticosteroid receptors on the serotonin-induced hyperpolarization of the membrane responses is clearly reflected in the inhibitory effect of serotonin on synaptic responsiveness in the CA1 area. Serotonin 87-96 carbonic anhydrase 1 Rattus norvegicus 242-245 9787266-5 1998 The data show that the effect of in vivo activation of corticosteroid receptors on the serotonin-induced hyperpolarization of the membrane responses is clearly reflected in the inhibitory effect of serotonin on synaptic responsiveness in the CA1 area. Serotonin 198-207 carbonic anhydrase 1 Rattus norvegicus 242-245 22331903-1 2012 N-acetylserotonin (NAS) is synthesized from serotonin by arylalkylamine N-acetyltransferase (AANAT), which is predominantly expressed in the pineal gland and retina. Serotonin 8-17 arylalkylamine N-acetyltransferase Mus musculus 57-91 9705076-9 1998 The phorbol myristate acetate (PMA), which mimics the induction of interstitial collagenase by serotonin, fails to affect the inhibition of alpha2M production. Serotonin 95-104 matrix metallopeptidase 1 Rattus norvegicus 67-91 9753154-11 1998 Interestingly, intracerebroventricular pretreatment with the IL-1 receptor antagonist showed that the effects of IL-2 on hippocampal serotonin were completely dependent on endogenous brain IL-1. Serotonin 133-142 interleukin 2 Rattus norvegicus 113-117 22331903-1 2012 N-acetylserotonin (NAS) is synthesized from serotonin by arylalkylamine N-acetyltransferase (AANAT), which is predominantly expressed in the pineal gland and retina. Serotonin 8-17 arylalkylamine N-acetyltransferase Mus musculus 93-98 21570786-2 2012 We report four cases of fatal serotonin toxicity caused by the combination of MDMA and moclobemide, a reversible MAO-A inhibitor with potent serotonergic activity. Serotonin 30-39 monoamine oxidase A Homo sapiens 113-118 9486827-6 1998 In contrast, few enkephalin-containing neuronal afferents to the hypoglossal nucleus also contain serotonin. Serotonin 98-107 proenkephalin Rattus norvegicus 17-27 9510054-0 1998 Serotonin and carbachol induced suppression of synaptic excitability in rat CA1 hippocampal area: effects of corticosteroid receptor activation. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 76-79 9510054-1 1998 Serotonin (5HT) and the cholinergic analogue carbachol (CCh) act on neurons in the hippocampal CA1 area through pre- and post-synaptic receptors. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 95-98 10510338-0 1999 Leptin increases serotonin turnover by inhibition of brain nitric oxide synthesis. Serotonin 17-26 leptin Mus musculus 0-6 10510338-1 1999 Leptin administration inhibits diencephalic nitric oxide synthase (NOS) activity and increases brain serotonin (5-HT) metabolism in mice. Serotonin 101-110 leptin Mus musculus 0-6 10501177-2 1999 AA-NAT catalyzes the key regulatory step controlling rhythmic melatonin output: the acetylation of serotonin. Serotonin 99-108 aralkylamine N-acetyltransferase Rattus norvegicus 0-6 9510054-1 1998 Serotonin (5HT) and the cholinergic analogue carbachol (CCh) act on neurons in the hippocampal CA1 area through pre- and post-synaptic receptors. Serotonin 11-14 carbonic anhydrase 1 Rattus norvegicus 95-98 22787593-9 2012 Chronic infusion of recombinant interleukin receptor antagonist into the hippocampus, as well as infusion of a selective glucocorticoid receptor antagonist or selective 5-HT1A blocker into the raphe restored evoked serotonin release and behavior. Serotonin 215-224 5-hydroxytryptamine receptor 1A Homo sapiens 169-175 9510054-3 1998 In the present study, we examined the consequences of steroid modulation of these post-synaptic membrane effects and/or possible pre-synaptic effects by 5HT and CCh for the excitability in the CA1 area, using extracellular field potential or intracellular recordings from individual pyramidal neurons. Serotonin 153-156 carbonic anhydrase 1 Rattus norvegicus 193-196 9510054-5 1998 In slices from adrenally intact rats, both 5HT (3-30 microM) and CCh (1-10 microM) induced a dose-dependent suppression of the synaptic field responses evoked in the CA1 area by stimulation of the Schaffer collaterals. Serotonin 43-46 carbonic anhydrase 1 Rattus norvegicus 166-169 9884126-2 1998 Pharmacological studies have shown that serotonin, via its action at 5HT1A and/or 5HT1B receptor sites, modulates the display of intermale aggressive behavior and that its effects serve to decrease behavioral expression. Serotonin 40-49 5-hydroxytryptamine receptor 1A Homo sapiens 69-74 9884126-5 1998 As an initial step toward characterizing the interaction between the systems, studies were conducted that assessed hormonal modulation of serotonin function at 5HT1A and 5HT1B receptor sites. Serotonin 138-147 5-hydroxytryptamine receptor 1A Homo sapiens 160-175 9886141-6 1998 Microinjection of serotonin into the region of the cholinergic basalis neurons produces an increase in slow wave activity, presumably by stimulating 5-HT1A receptors. Serotonin 18-27 5-hydroxytryptamine receptor 1A Homo sapiens 149-155 10527409-5 1999 After 15 minute incubation with 400 nM cathepsin G at 37 degrees C, 52+/-3% of [14C]serotonin had been released, and glycoprotein Ib was degraded. Serotonin 84-93 cathepsin G Homo sapiens 39-50 10527409-8 1999 Aggregation and release of residual [14C]serotonin in response to 0.1-1.0 U/mL thrombin was blocked or greatly reduced by the cathepsin G pretreatment. Serotonin 41-50 cathepsin G Homo sapiens 126-137 22162429-1 2012 Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. Serotonin 113-122 monoamine oxidase A Homo sapiens 0-19 10498842-2 1999 The effect of nociceptin (NC) on 5-hydroxytryptamine (5-HT) release was studied in rat cerebral cortex slices preincubated with [3H]-5-HT and electrically stimulated (3 Hz, for 2 min) at the 45th (St1) and the 75th (St2) min of superfusion. Serotonin 33-52 prepronociceptin Rattus norvegicus 14-24 10498842-2 1999 The effect of nociceptin (NC) on 5-hydroxytryptamine (5-HT) release was studied in rat cerebral cortex slices preincubated with [3H]-5-HT and electrically stimulated (3 Hz, for 2 min) at the 45th (St1) and the 75th (St2) min of superfusion. Serotonin 54-58 prepronociceptin Rattus norvegicus 14-24 9408240-6 1997 Precontraction of umbilical artery with serotonin followed by forskolin treatment led to increases in the phosphorylation of HSP27. Serotonin 40-49 heat shock protein family B (small) member 1 Homo sapiens 125-130 9348548-4 1997 Substantial regional differences in the density and distribution of CRH-immunoreactive axons were found in the dopamine-, noradrenaline- and serotonin-containing cell body regions of the human brainstem. Serotonin 141-150 corticotropin releasing hormone Homo sapiens 68-71 9517442-0 1997 Serotonin inhibits epileptiform discharge by activation of 5-HT1A receptors in CA1 pyramidal neurons. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 79-82 22162429-1 2012 Monoamine oxidase A (MAOA) is the enzyme responsible for degradation of several monoamines, such as dopamine and serotonin that are considered as being two of the most important neurotransmitters involved in the pathophysiology of schizophrenia. Serotonin 113-122 monoamine oxidase A Homo sapiens 21-25 9353800-4 1997 Neurochemicals commonly reported in the vLGN and IGL are neuropeptide Y, GABA, enkephalin, and nitric oxide synthase (localized in cells) and serotonin, acetylcholine, histamine, dopamine and noradrenalin (localized in fibers). Serotonin 142-151 immunoglobulin lambda locus Homo sapiens 49-52 10530928-12 1999 In the serotonin 5-HT1A receptor model, the benzamide phenyl rings of both enantiomers were involved in hydrophobic face-to-face interactions with Phe112 in TM3, while their protonated nitrogen atoms formed a reinforced electrostatic interaction with Asp116 in TM3. Serotonin 7-16 5-hydroxytryptamine receptor 1A Homo sapiens 17-32 22133459-1 2012 N"-cyanopicolinamidine derivatives, linked to an arylpiperazine moiety, were prepared and their affinity to serotonin 5-HT(1A), 5-HT(2A) and 5-HT(2C) receptors were evaluated. Serotonin 108-117 5-hydroxytryptamine receptor 1A Homo sapiens 118-125 9311654-0 1997 Adenosine A3 receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine. Serotonin 102-121 adenosine A3 receptor Rattus norvegicus 0-21 22754301-1 2012 Tryptophan hydroxylase-1 (TPH1) is a key enzyme in the synthesis of serotonin. Serotonin 68-77 tryptophan hydroxylase 1 Homo sapiens 0-24 10566952-3 1999 Such changes can be reconstituted in dissociated cell culture by repeated presentations of the modulatory neurotransmitter serotonin (5HT) and are associated with an activity-dependent downregulation of NCAM-related cell adhesion molecules thought to contribute to cell recognition and axonal outgrowth during development. Serotonin 123-132 neural cell adhesion molecule 1 Homo sapiens 203-207 10566952-3 1999 Such changes can be reconstituted in dissociated cell culture by repeated presentations of the modulatory neurotransmitter serotonin (5HT) and are associated with an activity-dependent downregulation of NCAM-related cell adhesion molecules thought to contribute to cell recognition and axonal outgrowth during development. Serotonin 134-137 neural cell adhesion molecule 1 Homo sapiens 203-207 21956448-0 2012 Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Serotonin 76-85 methyl CpG binding protein 2 Mus musculus 27-32 9292630-1 1997 Animal experimental studies suggest that the therapeutic effect of selective serotonin re-uptake inhibitors (SSRIs) may involve neuroadaptive changes in pre- and post-synaptic serotonin1A (5-HT1A) receptors. Serotonin 77-86 5-hydroxytryptamine receptor 1A Homo sapiens 189-195 23119095-2 2012 Serotonin (5-HT) is significantly increased in the null mutants of Drosophila Fmr1, and elevated 5-HT brain levels result in cognitive and behavioral deficits in human patients. Serotonin 0-9 Fmr1 Drosophila melanogaster 78-82 9268195-0 1997 Different requirement of intracellular calcium and protein kinase C for arachidonic acid release and serotonin secretion in cathepsin G-activated platelets. Serotonin 101-110 cathepsin G Homo sapiens 124-135 10329462-2 1999 Presently, we find the expression of the serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) mRNA, the rate-limiting enzyme in the conversion of serotonin to melatonin, in the rat suprachiasmatic nucleus (SCN) which contains the biological circadian clock in mammals. Serotonin 41-50 aralkylamine N-acetyltransferase Rattus norvegicus 72-106 10329462-2 1999 Presently, we find the expression of the serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT) mRNA, the rate-limiting enzyme in the conversion of serotonin to melatonin, in the rat suprachiasmatic nucleus (SCN) which contains the biological circadian clock in mammals. Serotonin 41-50 aralkylamine N-acetyltransferase Rattus norvegicus 108-114 10340308-3 1999 The P2X1-7 active P2 purinoceptor agonist, 2-methylthioATP (2-MeSATP: 100 microM) increased the extracellular serotonin level drastically (638%), while the P2X1,3 active P2 purinoceptor agonist, alpha, beta-methylene-L-ATP (alpha, beta-meATP: 100 microM) produced a small increase (132%) in the serotonin level. Serotonin 110-119 purinergic receptor P2X 1 Homo sapiens 4-10 9242958-2 1997 Serotonin alone did not stimulate SMC migration but stimulated it at physiological concentrations in the presence of other migration factors such as SMC-derived migration factor, platelet-derived migration factor and fibronectin. Serotonin 0-9 fibronectin 1 Rattus norvegicus 217-228 22403677-8 2012 Expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, and the 5-HT(7) receptor (HTR7), which regulates mammary gland involution, were significantly increased in mammary glands of HFD animals. Serotonin 75-84 tryptophan hydroxylase 1 Homo sapiens 14-38 9205951-5 1997 In contrast, serotonin, dihydroergotamine, sumatriptan, naratriptan and alniditan, which are effective in acute interruption of migraine attacks, each displayed high efficacy (Emax = 100, 100, 92.6, 79.3, 79.1% respectively) and marked affinity (Ki = 18.7, 0.6, 127, 26.4 and 3.0 nM respectively) at 5-HT1A receptors. Serotonin 13-22 5-hydroxytryptamine receptor 1A Homo sapiens 300-306 10340308-3 1999 The P2X1-7 active P2 purinoceptor agonist, 2-methylthioATP (2-MeSATP: 100 microM) increased the extracellular serotonin level drastically (638%), while the P2X1,3 active P2 purinoceptor agonist, alpha, beta-methylene-L-ATP (alpha, beta-meATP: 100 microM) produced a small increase (132%) in the serotonin level. Serotonin 110-119 pyrimidinergic receptor P2Y6 Homo sapiens 18-33 10340308-3 1999 The P2X1-7 active P2 purinoceptor agonist, 2-methylthioATP (2-MeSATP: 100 microM) increased the extracellular serotonin level drastically (638%), while the P2X1,3 active P2 purinoceptor agonist, alpha, beta-methylene-L-ATP (alpha, beta-meATP: 100 microM) produced a small increase (132%) in the serotonin level. Serotonin 110-119 pyrimidinergic receptor P2Y6 Homo sapiens 170-185 10435012-8 1999 Studies of aortic rings from eNOS-/- mice revealed a complete lack of endothelium-dependent vascular relaxation in response to acetylcholine and the calcium ionophore A23187 and an increase in sensitivity to phenylephrine, serotonin and nitroglycerin. Serotonin 223-232 nitric oxide synthase 3, endothelial cell Mus musculus 29-33 9109104-1 1997 It has been reported that the 5-HT1A autoreceptor antagonist pindolol can accelerate the antidepressant response to the selective serotonin (5-HT) reuptake inhibitor (SSRI) paroxetine, presumably by preventing the initial decrease in firing activity of 5-HT neurons produced by the SSRI. Serotonin 130-139 5-hydroxytryptamine receptor 1A Homo sapiens 30-36 22403677-8 2012 Expression of tryptophan hydroxylase 1 (TPH1), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, and the 5-HT(7) receptor (HTR7), which regulates mammary gland involution, were significantly increased in mammary glands of HFD animals. Serotonin 75-84 tryptophan hydroxylase 1 Homo sapiens 40-44 9151945-2 1997 Dopamine (10 and 100 microM) and 5-hydroxytryptamine (1 to 100 microM) enhanced the inward current activated by extracellular ATP through P2X2 and P2X4 purinoceptors. Serotonin 33-52 purinergic receptor P2X, ligand gated ion channel, 4 L homeolog Xenopus laevis 147-151 9930750-2 1999 A quantitative double-label in situ hybridization technique was used to examine CNS GTPCH mRNA expression within serotonin, dopamine, and norepinephrine neurons of male and female wild-type and hph-1 mice. Serotonin 113-122 GTP cyclohydrolase 1 Mus musculus 84-89 9930750-3 1999 In wild-type male and female animals the highest levels of GTPCH mRNA expression were observed within serotonin neurons, followed by norepinephrine and then dopamine neurons. Serotonin 102-111 GTP cyclohydrolase 1 Mus musculus 59-64 9930750-5 1999 GTPCH mRNA abundance in all three cell types was lower in hph-1 male than in wild-type male mice, with the greatest reduction in serotonin neurons. Serotonin 129-138 GTP cyclohydrolase 1 Mus musculus 0-5 9930750-6 1999 GTPCH mRNA levels were also lower in hph-1 female than in wild-type female mice, again with the greatest reduction occurring in serotonin neurons. Serotonin 128-137 GTP cyclohydrolase 1 Mus musculus 0-5 22413019-4 2012 METHODOLOGY/PRINCIPAL FINDINGS: We showed previously that the profibrotic GPCR agonist serotonin (5-HT) induced kidney mesangial cell proliferation through ADAM17 activation and heparin-binding epidermal growth factor (HB-EGF) shedding. Serotonin 87-96 C-X-C motif chemokine receptor 6 Homo sapiens 74-78 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Serotonin 54-63 monoamine oxidase A Homo sapiens 244-263 22413019-4 2012 METHODOLOGY/PRINCIPAL FINDINGS: We showed previously that the profibrotic GPCR agonist serotonin (5-HT) induced kidney mesangial cell proliferation through ADAM17 activation and heparin-binding epidermal growth factor (HB-EGF) shedding. Serotonin 87-96 heparin binding EGF like growth factor Homo sapiens 178-217 9112832-3 1997 Superimposition of norepinephrine and gauche forms of serotonin and mociobemide suggest that the phenyl ring, electronegative group attached to the aromatic ring and the amine terminal group may serve as the recognition elements for binding to monoamine oxidase-A (MAO-A). Serotonin 54-63 monoamine oxidase A Homo sapiens 265-270 22413019-4 2012 METHODOLOGY/PRINCIPAL FINDINGS: We showed previously that the profibrotic GPCR agonist serotonin (5-HT) induced kidney mesangial cell proliferation through ADAM17 activation and heparin-binding epidermal growth factor (HB-EGF) shedding. Serotonin 87-96 heparin binding EGF like growth factor Homo sapiens 219-225 9878747-2 1999 Further, the treatment with NPFF decreased the levels of serotonin, and increased the glutamate and GABA content in the medial prefrontal cortex of amphetamine-sensitized rats. Serotonin 57-66 neuropeptide FF-amide peptide precursor Rattus norvegicus 28-32 21835768-11 2011 We conclude that rOct1, or rOct1 and rOct2 limit the rate of the renal excretion of serotonin. Serotonin 84-93 solute carrier family 22 member 2 Rattus norvegicus 37-42 9951564-3 1999 AA-NAT leads to formation of N-acetylserotonin from serotonin, and in the pineal gland, to melatonin synthesis. Serotonin 37-46 aralkylamine N-acetyltransferase Rattus norvegicus 0-6 9138675-1 1997 At recombinant human 5-hydroxytryptamine (5-HT)5-HT1A receptors expressed in Chinese hamster ovary cells (CHO-5-HT1A), 5-carboxamidotryptamine (5-CT), acted as a full agonist (relative to 5-HT = 100%) for stimulation of receptor-mediated [35S]-GTP gamma S (guanylyl 5"-[gamma-thio]-tryphosphate) binding. Serotonin 21-40 5-hydroxytryptamine receptor 1A Homo sapiens 47-53 9138675-1 1997 At recombinant human 5-hydroxytryptamine (5-HT)5-HT1A receptors expressed in Chinese hamster ovary cells (CHO-5-HT1A), 5-carboxamidotryptamine (5-CT), acted as a full agonist (relative to 5-HT = 100%) for stimulation of receptor-mediated [35S]-GTP gamma S (guanylyl 5"-[gamma-thio]-tryphosphate) binding. Serotonin 42-46 5-hydroxytryptamine receptor 1A Homo sapiens 47-53 9176059-1 1997 Serotonin stimulates inositol phosphate production and intracellular calcium mobilization in cultured rat retinal pigment epithelial (RPE) cells through interaction with 5-HT2A receptors, but decreases cAMP production in cultured human RPE cells via 5-HT1A receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 250-256 9176059-6 1997 The antagonists ketanserin, methysergide and spiperone attenuated the action of serotonin, while yohimbine and spiroxatrine were ineffectual, thus indicating that the potentiating effect was through the 5-HT1A receptor. Serotonin 80-89 5-hydroxytryptamine receptor 1A Homo sapiens 203-209 21871532-6 2011 TREK1 gender differences may be related to gender differences in serotonin and require further research. Serotonin 65-74 potassium channel, subfamily K, member 2 Mus musculus 0-5 9016944-1 1996 We previously reported a significant mitogenic effect of serotonin (5-hydroxytryptamine, 5-HT) on human small-cell lung carcinoma cells (SCLC, GLC-8), mediated by both 5-HT1D and 5-HT1A receptors. Serotonin 57-66 5-hydroxytryptamine receptor 1A Homo sapiens 179-185 9016944-1 1996 We previously reported a significant mitogenic effect of serotonin (5-hydroxytryptamine, 5-HT) on human small-cell lung carcinoma cells (SCLC, GLC-8), mediated by both 5-HT1D and 5-HT1A receptors. Serotonin 68-87 5-hydroxytryptamine receptor 1A Homo sapiens 179-185 9017248-0 1996 Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats. Serotonin 11-20 carbonic anhydrase 1 Rattus norvegicus 57-60 9017248-6 1996 Serotonin (20 microM) inhibited the directly and synaptically evoked action potentials in GEPR-9 CA1 neurons, as it did in the Sprague Dawley neurons, but only in some and not all of the neurons tested (blocked the directly evoked potentials in 57% and synaptically evoked potentials in 33.3% of the total neurons). Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 97-100 9017248-9 1996 The effects of the selective serotonin 5-HT1A receptor agonist, 8-OH-DPAT (20 microM) on GEPR-9 pyramidal CA1 neurons were similar to those of serotonin, except the magnitude of hyperpolarization and reduction of membrane input resistance were less than those produced by serotonin. Serotonin 29-38 carbonic anhydrase 1 Rattus norvegicus 106-109 9017248-10 1996 We conclude that the apparent decrease in sensitivity of the GEPR-9 CA1 pyramidal neurons to serotonin may represent a deficiency of serotonin 5-HT1A receptor. Serotonin 93-102 carbonic anhydrase 1 Rattus norvegicus 68-71 10333979-10 1998 The hypothesis to explain why SSRIs have such diverse therapeutic actions is that somatodendritic 5HT1A autoreceptor desensitization increases serotonin in those critical brain regions and at those key serotonin receptor subtype(s) which may mediate the pathophysiologies of the various disorders. Serotonin 143-152 5-hydroxytryptamine receptor 1A Homo sapiens 98-103 9832151-2 1998 The glycosylation inhibitor tunicamycin induced a dose-dependent decrease in the rVMAT1-mediated uptake of [3H]serotonin. Serotonin 111-120 solute carrier family 18 member A1 Rattus norvegicus 81-87 20818612-2 2011 Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 96-100 8921260-8 1996 In contrast, NT-3 selectively increased behaviours that are mediated primarily by serotonin, such as wet-dog shakes. Serotonin 82-91 neurotrophin 3 Rattus norvegicus 13-17 20818612-2 2011 Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Serotonin 0-9 LIM homeobox transcription factor 1 beta Homo sapiens 203-208 8921260-11 1996 Most of the behavioural effects of the neurotrophins are consistent with the view that BDNF increases activity of both dopaminergic and serotonergic systems within the nigrostriatal system, and that NT-3 increases serotonin activity. Serotonin 214-223 neurotrophin 3 Rattus norvegicus 199-203 9881101-1 1998 A new chemical class of potential atypical antipsychotic agents, based on the pharmacological concept of mixed dopamine D2 receptor antagonism and serotonin 5-HT1A receptor agonism, was designed by combining the structural features of the 2-(N,N-di-n-propylamino)tetralins (DPATs) and the 2-pyrrolidinylmethyl-derived substituted benzamides in a structural hybrid. Serotonin 147-156 5-hydroxytryptamine receptor 1A Homo sapiens 157-172 8832571-7 1996 Progesterone analogs, which inhibit the serotonin-dependent activation of the gene for interstitial collagenase, had no effect on the ability of serotonin to decrease collagen mRNA. Serotonin 40-49 matrix metallopeptidase 1 Rattus norvegicus 87-111 22379463-4 2011 Pharmacological and neurochemical data are relevant that facilitation of serotonin neurotransmission via hippocampus due to desensitization of somatodendritic 5-HT1A receptors may lead to adaptation to stress. Serotonin 73-82 5-hydroxytryptamine receptor 1A Homo sapiens 159-165 8832571-9 1996 Serotonin also decreased levels of the mRNAs for type III collagen and fibronectin, but had no effect on the mRNAs for type IV collagen. Serotonin 0-9 fibronectin 1 Rattus norvegicus 71-82 8832571-10 1996 These results indicate that serotonin, previously shown to upregulate the interstitial collagenase gene, downregulates the gene for type I collagen and other extracellular matrix proteins, possibly by a novel mechanism of action downstream of 5-HT2 receptor binding. Serotonin 28-37 matrix metallopeptidase 1 Rattus norvegicus 74-98 9692713-0 1998 Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine1A receptor activation. Serotonin 11-20 carbonic anhydrase 1 Rattus norvegicus 71-74 21611977-5 2011 Inhibition of serotonin neuron activity by systemic administration of a 5-HT(1A) agonist suppressed graft-induced dyskinesias. Serotonin 14-23 5-hydroxytryptamine receptor 1A Homo sapiens 72-79 9738019-0 1998 Serotonin-mediated production of interstitial collagenase by uterine smooth muscle cells requires interleukin-1alpha, but not interleukin-1beta. Serotonin 0-9 matrix metallopeptidase 1 Homo sapiens 33-57 9738019-0 1998 Serotonin-mediated production of interstitial collagenase by uterine smooth muscle cells requires interleukin-1alpha, but not interleukin-1beta. Serotonin 0-9 interleukin 1 alpha Homo sapiens 98-116 8981559-1 1996 Pinoline (6-methoxy-1,2,3,4-tetrahydro-beta-carboline) is a naturally occurring compound in the mammalian body which inhibits serotonin (5-hydroxytryptamine) uptake and monoamine oxidase-A activity. Serotonin 126-135 monoamine oxidase A Homo sapiens 169-188 9738019-1 1998 The activation of the gene for interstitial collagenase in myometrial smooth muscle cells is absolutely dependent upon the presence of serotonin. Serotonin 135-144 matrix metallopeptidase 1 Homo sapiens 31-55 21602053-0 2011 Towards a serotonin-dependent leptin roadmap in the brain. Serotonin 10-19 leptin Homo sapiens 30-36 9738019-2 1998 Our previous studies investigating the mechanisms of this induction demonstrated that the mRNAs of both interleukin-1 (IL-1) isoforms, IL-1alpha and IL-1beta, are induced by serotonin and that the induction of IL-1 is required for the subsequent induction of collagenase. Serotonin 174-183 interleukin 1 alpha Homo sapiens 135-144 9738019-7 1998 Western analysis indicated that detectable levels of IL-1alpha protein, but not that of IL-1beta, are produced at the time of serotonin-dependent collagenase induction. Serotonin 126-135 interleukin 1 alpha Homo sapiens 53-62 9738019-9 1998 Taken together, the results of our study indicate that IL-1alpha, but not IL-1beta, plays an obligatory role in multiple serotonin-mediated gene regulations in the myometrial smooth muscle cell. Serotonin 121-130 interleukin 1 alpha Homo sapiens 55-64 8669487-7 1996 Serotonin inhibited cAMP production, had no effect on inositol phosphate production, and activated phospholipase A2, causing release of arachidonic acid. Serotonin 0-9 phospholipase A2 group IB Rattus norvegicus 99-115 9005353-4 1996 The development of new serotonin selective antidepressants and selective reversible inhibitors of monoamine oxidase A has led to the use of more and more substances that can cause these life-threatening complications if they are taken in too high doses or together with other drugs. Serotonin 23-32 monoamine oxidase A Homo sapiens 98-117 21602053-3 2011 Recent genetic studies, however, indicate that these physiological functions, notably the regulation of appetite and bone mass accrual by leptin, take place for the most part through inhibition of serotonin (5-hydroxytryptamine) synthesis and release by brainstem neurons. Serotonin 197-206 leptin Homo sapiens 138-144 21602053-5 2011 This has led to proof-of-principle studies showing that selective inhibition of the leptin-serotonin axis is a viable therapeutic approach to treat appetite disorders. Serotonin 91-100 leptin Homo sapiens 84-90 9639277-0 1998 Apposition of enkephalin- and neurotensin-immunoreactive neurons by serotonin-immunoreactive varicosities in the rat spinal cord. Serotonin 68-77 proenkephalin Rattus norvegicus 14-24 21693154-2 2011 In the present study we demonstrate that the life-long deletion of the noradrenaline transporter (NET) induced up-regulation of two other monoamine transporters, dopamine and serotonin (DAT and SERT, respectively). Serotonin 175-184 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 71-96 9639277-4 1998 Using a double immunofluorescence technique, serotonin-immunoreactive varicosities were observed to abut the soma or proximal dendrites of [Met]enkephalin- and neurotensin-immunoreactive neurons. Serotonin 45-54 proenkephalin Rattus norvegicus 144-154 9639277-5 1998 Nearly 75% of all [Met]enkephalin- and neurotensin-immunoreactive neurons were apposed by serotonin-immunoreactive varicosities in the marginal zone and dorsal gray commissure. Serotonin 90-99 proenkephalin Rattus norvegicus 23-33 9639277-7 1998 [Met]enkephalin-immunoreactive neurons also were bordered by serotonin-immunoreactive varicosities in the nucleus proprius (65%) and sacral parasympathetic nucleus (75%). Serotonin 61-70 proenkephalin Rattus norvegicus 5-15 9639277-9 1998 The mode of action of spinal serotonin on enkephalin and neurotensin neurons may be through "volume" transmission vs synaptic or "wiring" transmission. Serotonin 29-38 proenkephalin Rattus norvegicus 42-52 8732267-9 1996 The selective NK1 receptor antagonist, FK 888 (1 microM) markedly attenuated the contractions to 5-HT and 5-MeOT. Serotonin 97-101 substance-P receptor Cavia porcellus 14-26 8793911-2 1996 The selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and 5-hydroxytryptamine (5-HT) caused concentration-dependent inhibitions of the electrically evoked release of [3H]acetylcholine from myenteric plexus preparations that had been preincubated with [3H]choline. Serotonin 94-113 5-hydroxytryptamine receptor 1A Cavia porcellus 14-20 21693154-2 2011 In the present study we demonstrate that the life-long deletion of the noradrenaline transporter (NET) induced up-regulation of two other monoamine transporters, dopamine and serotonin (DAT and SERT, respectively). Serotonin 175-184 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 98-101 8626761-0 1996 Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. Serotonin 0-9 amyloid beta (A4) precursor protein Mus musculus 48-73 21730126-3 2011 To determine whether TR3/Nur77 had a more general role in regulating vascular permeability, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular permeabilizing agents, also increased TR3/Nur77 expression acutely in EC. Serotonin 117-126 nuclear receptor subfamily 4, group A, member 1 Mus musculus 21-24 8548905-1 1996 BACKGROUND: We previously reported that mast cell degranulation causes histamine and P-selectin-dependent leukocyte rolling and platelet-activating factor (PAF)- and CD18-associated leukocyte adhesion, whereas others have reported serotonin-induced edema formation. Serotonin 231-240 selectin P Homo sapiens 85-95 8917909-2 1996 Generally, in anestrous ewes beta-endorphin and/or corticoliberin significantly change extracellular concentrations of monoamine metabolites in the MBH-ME, but in estrous ewes both beta-endorphin and CRF alters also dopamine, noradrenaline and serotonin levels. Serotonin 244-253 corticotropin releasing hormone Homo sapiens 51-65 8750929-5 1996 Both human keratinocytes and melanocytes expressed significant levels of monoamine oxidase A (MAO-A) activities as shown using 14C-labelled 5-hydroxytryptamine as substrate and immunohistochemical staining with mouse monoclonal antibody. Serotonin 140-159 monoamine oxidase A Homo sapiens 73-92 21730126-3 2011 To determine whether TR3/Nur77 had a more general role in regulating vascular permeability, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular permeabilizing agents, also increased TR3/Nur77 expression acutely in EC. Serotonin 117-126 nuclear receptor subfamily 4, group A, member 1 Mus musculus 25-30 8750929-5 1996 Both human keratinocytes and melanocytes expressed significant levels of monoamine oxidase A (MAO-A) activities as shown using 14C-labelled 5-hydroxytryptamine as substrate and immunohistochemical staining with mouse monoclonal antibody. Serotonin 140-159 monoamine oxidase A Homo sapiens 94-99 21730126-3 2011 To determine whether TR3/Nur77 had a more general role in regulating vascular permeability, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular permeabilizing agents, also increased TR3/Nur77 expression acutely in EC. Serotonin 117-126 nuclear receptor subfamily 4, group A, member 1 Mus musculus 222-225 8880055-1 1996 OBJECTIVE: The purpose of this pharmacokinetic study was to investigate the dose-dependent inhibition of model substrates for CYP2D6, CYP2C19 and CYP1A2 by four marketed selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine and paroxetine. Serotonin 180-189 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 146-152 21730126-3 2011 To determine whether TR3/Nur77 had a more general role in regulating vascular permeability, we found that histamine, serotonin, and platelet-activating factor, small molecule vascular permeabilizing agents, also increased TR3/Nur77 expression acutely in EC. Serotonin 117-126 nuclear receptor subfamily 4, group A, member 1 Mus musculus 226-231 8698676-1 1996 The article focuses on the effects of the serotonin selective reuptake inhibitors (SSRIs) on specific drug metabolizing isoenzymes: CYP2D6, CYP3A3/4, CYP1A2, CYP2C9, and CYP2C19. Serotonin 42-51 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 158-164 21372171-2 2011 We found previously that GSK3beta selectively interacts with 5-hydroxytryptamine-1B receptors (5-HT1BR) that have important functions in serotonin neurotransmission and behavior. Serotonin 137-146 glycogen synthase kinase 3 beta Mus musculus 25-33 7589574-3 1995 Treatment of rat mesangial cells with platelet products PDGF-AB, PDGF-BB or serotonin transiently induced MCP-1 expression with a maximum after 2 to 4 h and a decline to baseline after 6 to 8 h. Different kinetics were observed with interleukin-1 beta (IL-1 beta), which induced a long lasting elevation of MCP-1 mRNA for more than 20 h. Together, PDGF and IL-1 beta synergistically induced MCP-1 expression. Serotonin 76-85 C-C motif chemokine ligand 2 Rattus norvegicus 307-312 8566173-0 1995 Mitogenic effect of serotonin in human small cell lung carcinoma cells via both 5-HT1A and 5-HT1D receptors. Serotonin 20-29 5-hydroxytryptamine receptor 1A Homo sapiens 80-97 7495925-1 1995 Previous reports based on studies with serotonin (5-HT) precursors or direct acting agonists have suggested that postsynaptic 5-HT1A and 5-HT2A/5-HT2C receptors may stimulate cortisol and prolactin (PRL) secretion in man. Serotonin 39-48 5-hydroxytryptamine receptor 1A Homo sapiens 126-138 21372171-5 2011 Molecular ablation of GSK3beta and GSK3 inhibitors abolished serotonin-induced change of 5-HT1BR coupling to G(i)alpha(2) and associated signaling but had no effect on serotonin-induced recruitment of beta-arrestin2 to 5-HT1BR. Serotonin 61-70 glycogen synthase kinase 3 beta Mus musculus 22-30 21372171-5 2011 Molecular ablation of GSK3beta and GSK3 inhibitors abolished serotonin-induced change of 5-HT1BR coupling to G(i)alpha(2) and associated signaling but had no effect on serotonin-induced recruitment of beta-arrestin2 to 5-HT1BR. Serotonin 61-70 glycogen synthase kinase 3 beta Mus musculus 22-26 8739199-7 1995 In the brain of untreated OB rats, the concentrations of noradrenaline were reduced; IL-2 treatment significantly increased the concentrations of noradrenaline and serotonin. Serotonin 164-173 interleukin 2 Rattus norvegicus 85-89 21372171-5 2011 Molecular ablation of GSK3beta and GSK3 inhibitors abolished serotonin-induced change of 5-HT1BR coupling to G(i)alpha(2) and associated signaling but had no effect on serotonin-induced recruitment of beta-arrestin2 to 5-HT1BR. Serotonin 61-70 arrestin, beta 2 Mus musculus 201-215 21471224-0 2011 Alpha1,6-fucosyltransferase-deficient mice exhibit multiple behavioral abnormalities associated with a schizophrenia-like phenotype: importance of the balance between the dopamine and serotonin systems. Serotonin 184-193 fucosyltransferase 8 Mus musculus 0-27 7547436-0 1995 Serotonin causes acute gastric mucosal injury in rats, probably via 5HT1D receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1D Rattus norvegicus 68-73 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Serotonin 66-75 monoamine oxidase A Homo sapiens 14-33 7792602-1 1995 Deficiency in monoamine oxidase A (MAOA), an enzyme that degrades serotonin and norepinephrine, has recently been shown to be associated with aggressive behavior in men of a Dutch family. Serotonin 66-75 monoamine oxidase A Homo sapiens 35-39 21471224-10 2011 The levels of serotonin metabolites were significantly decreased in both the striatum and nucleus accumbens of the Fut8(-/-) mice. Serotonin 14-23 fucosyltransferase 8 Mus musculus 115-119 21619616-1 2011 The serotonin-1A (5-HT1A) receptor is among the most abundant and widely distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an autoreceptor where it plays a critical role in regulating the activity of the entire serotonin system. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 18-24 7791083-1 1995 Corticosterone (CT) treatment decreases the magnitude of the 5-hydroxytryptamine (5-HT)1A receptor-mediated hyperpolarization in rat CA1 hippocampal pyramidal neurons. Serotonin 61-80 carbonic anhydrase 1 Rattus norvegicus 133-136 21619616-1 2011 The serotonin-1A (5-HT1A) receptor is among the most abundant and widely distributed 5-HT receptors in the brain, but is also expressed on serotonin neurons as an autoreceptor where it plays a critical role in regulating the activity of the entire serotonin system. Serotonin 139-148 5-hydroxytryptamine receptor 1A Homo sapiens 18-24 7545013-4 1995 4-Hydroxyphenylethanol inhibits monoamine oxidase A in an incompetitive manner with respect to the substrate, serotonin (Ki = 1.4 mM). Serotonin 110-119 amine oxidase [flavin-containing] A Oryctolagus cuniculus 32-51 21376144-0 2011 The neurotransmitter serotonin interrupts alpha-synuclein amyloid maturation. Serotonin 21-30 synuclein alpha Homo sapiens 42-57 21726200-4 2011 The present review provides a detailed analysis of the core promoters of NHE2, NHE3, DRA and PAT-1 and outlines the transcription factors involved in their basal regulation as well as in response to both physiological (butyrate, protein kinases and probiotics) and pathophysiological (cytokines and high levels of serotonin) stimuli. Serotonin 314-323 solute carrier family 36 member 1 Homo sapiens 93-98 7612161-0 1995 Serotonin depletion in the adult rat causes loss of the dendritic marker MAP-2. Serotonin 0-9 microtubule-associated protein 2 Rattus norvegicus 73-78 21195096-4 2011 Blockade of 5-HT1A receptor, but not that of the 5-HT2A/2C receptor, enhanced the effects of acute administration of mirtazapine on extracellular serotonin level in raphe nuclei. Serotonin 146-155 5-hydroxytryptamine receptor 1A Homo sapiens 12-27 21310276-4 2011 The characterization of this disorder provides evidence for the link between DHFR and metabolism of cerebral tetrahydrobiopterin, which is required for the formation of dopamine, serotonin, and norepinephrine and for the hydroxylation of aromatic amino acids. Serotonin 179-188 dihydrofolate reductase Homo sapiens 77-81 20658274-4 2011 Differences in the activation of the enzyme indoleamine 2,3-dioxygenase (IDO) and in the tryptophan-kynurenine metabolism resulting in an increased tryptophan and serotonin degradation and probably in an increased production of quinolinic acid might play a key role in major depression (MD). Serotonin 163-172 indoleamine 2,3-dioxygenase 1 Homo sapiens 73-76 20945066-1 2011 RATIONALE: Tryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (MDD); however, its actual role is uncertain. Serotonin 129-138 tryptophan hydroxylase 1 Homo sapiens 11-35 20945066-1 2011 RATIONALE: Tryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (MDD); however, its actual role is uncertain. Serotonin 129-138 tryptophan hydroxylase 1 Homo sapiens 37-41 20699107-8 2011 Altogether, the results support the idea that serotonin plays an active role in wakefulness, probably through the activation of 5-HT(1A) receptors that increases wake activities and reduces sleep in ring doves. Serotonin 46-55 5-hydroxytryptamine receptor 1A Homo sapiens 128-135 20940053-10 2011 Our results support the hypothesis that the increased IDO-mediated tryptophan metabolism along the Kyn pathway, leading to plasma Trp depletion and a decline of serotonin pathway, concurs to the development of depressive symptoms observed in HCV patients undergoing IFN-alpha therapy. Serotonin 161-170 indoleamine 2,3-dioxygenase 1 Homo sapiens 54-57 20121623-0 2010 Interactions of melatonin and serotonin with lactoperoxidase enzyme. Serotonin 30-39 lactoperoxidase Bos taurus 45-60 20121623-7 2010 The effect of melatonin and serotonin on lactoperoxidase was determined using ABTS as chromogenic substrate. Serotonin 28-37 lactoperoxidase Bos taurus 41-56 20739712-5 2010 We show that fluoxetine treatment and null mutation in the sole SERT gene mod-5 eliminate serotonin in specific neurons. Serotonin 90-99 Transporter Caenorhabditis elegans 74-79 20739712-6 2010 These neurons do not synthesize serotonin but import extracellular serotonin via MOD-5/SERT. Serotonin 67-76 Transporter Caenorhabditis elegans 81-86 20926677-0 2010 Serotonin, but not N-methyltryptamines, activates the serotonin 2A receptor via a ss-arrestin2/Src/Akt signaling complex in vivo. Serotonin 0-9 Rous sarcoma oncogene Mus musculus 95-98 20926677-3 2010 Here we report that serotonin differs from the psychoactive N-methyltryptamines by its ability to engage a beta-arrestin2-mediated signaling cascade in the frontal cortex. Serotonin 20-29 arrestin, beta 2 Mus musculus 107-121 20926677-8 2010 Biochemical studies demonstrate that serotonin stimulates Akt phosphorylation in the frontal cortex and in primary cortical neurons through the activation of a beta-arrestin2/phosphoinositide 3-kinase/Src/Akt cascade, whereas N-methyltryptamines do not. Serotonin 37-46 arrestin, beta 2 Mus musculus 160-174 20926677-8 2010 Biochemical studies demonstrate that serotonin stimulates Akt phosphorylation in the frontal cortex and in primary cortical neurons through the activation of a beta-arrestin2/phosphoinositide 3-kinase/Src/Akt cascade, whereas N-methyltryptamines do not. Serotonin 37-46 Rous sarcoma oncogene Mus musculus 201-204 20802307-4 2010 The involvement of the serotonin system in anxiety, particularly of 5HT1A receptors, has been widely documented. Serotonin 23-32 5-hydroxytryptamine receptor 1A Homo sapiens 68-73 11281940-1 1998 Desensitisation of serotonin 1A (5-HT-1A) receptors is a leading hypothesis for the mechanism of action of antidepressants which block serotonin reuptake. Serotonin 19-28 5-hydroxytryptamine receptor 1A Homo sapiens 33-40 11281940-10 1998 Results of this study demonstrate that ipsapirone, at a dose of 7.5 mg t.i.d., is an effective antidepressant agent in the treatment of MDD, supporting the hypothesised role of 5-HT-1A receptors in the mechanism of action of serotonin reuptake inhibitors. Serotonin 225-234 5-hydroxytryptamine receptor 1A Homo sapiens 177-184 9682270-0 1998 Modulation of CYP1A2 enzyme activity by indoleamines: inhibition by serotonin and tryptamine. Serotonin 68-77 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 14-20 9558376-9 1998 The introduction of +-MITF but not of mi-MITF normalized the serotonin content in mi/mi CMCs. Serotonin 61-70 melanocyte inducing transcription factor Homo sapiens 22-26 9580630-1 1998 5-Hydroxytryptamine (5-HT; serotonin) administration enhances GABAergic synaptic activity recorded in pyramidal neurons of the CA1 region of hippocampus. Serotonin 0-19 carbonic anhydrase 1 Rattus norvegicus 127-130 9580630-1 1998 5-Hydroxytryptamine (5-HT; serotonin) administration enhances GABAergic synaptic activity recorded in pyramidal neurons of the CA1 region of hippocampus. Serotonin 27-36 carbonic anhydrase 1 Rattus norvegicus 127-130 9705076-2 1998 Serotonin activates the genes for interstitial collagenase, interleukin-1alpha, -1beta and interleukin-6, among others. Serotonin 0-9 matrix metallopeptidase 1 Rattus norvegicus 34-58 9705076-3 1998 On the other hand, serotonin down-regulates the genes for types I and III collagen and fibronectin. Serotonin 19-28 fibronectin 1 Rattus norvegicus 58-98 10094179-6 1998 This abnormal behaviour of the stenotic artery has been associated with the occurrence of myocardial ischaemia, and has been thought to be either due to: endothelial dysfunction with reduced release or production of the endothelial derived relaxant factor (EDRF); an increased sympathetic stimulation during exercise; enhanced platelet aggregation with release of thromboxane A2 and serotonin; and/or a passive collapse of the disease-free vessel segment within the stenosis when blood-flow velocity increases during exercise. Serotonin 383-392 alpha hemoglobin stabilizing protein Homo sapiens 257-261 9442097-5 1998 Similarly, protein phosphatase (PP1/PP2A) inhibitors down-regulate 5HT transport and significantly elevate hSERT 32P incorporation, effects that are additive with those of PKC activators. Serotonin 67-70 protein phosphatase 2 phosphatase activator Homo sapiens 36-40 9444479-4 1998 Under physiological fluctuations of corticosteroid concentrations, predominantly MR-mediated effects suppress the activity of the raphe-hippocampal system, notably serotonin (5-HT)1A receptor-related activity: 5-HT1A receptors are down-regulated, and the cellular response to 5-HT1A receptor activation is attenuated. Serotonin 164-173 5-hydroxytryptamine receptor 1A Homo sapiens 210-225 9564621-1 1998 The deamination of 5-hydroxytryptamine, phenylethylamine and benzylamine by monoamine oxidases (MAO-A and B) and semicarbazide sensitive amine oxidase (SSAO) respectively has been studied in homogenates of human cystic and colonic arteries by radiochemical assays. Serotonin 19-38 monoamine oxidase A Homo sapiens 96-107 9564621-1 1998 The deamination of 5-hydroxytryptamine, phenylethylamine and benzylamine by monoamine oxidases (MAO-A and B) and semicarbazide sensitive amine oxidase (SSAO) respectively has been studied in homogenates of human cystic and colonic arteries by radiochemical assays. Serotonin 19-38 amine oxidase copper containing 2 Homo sapiens 113-150 9564621-1 1998 The deamination of 5-hydroxytryptamine, phenylethylamine and benzylamine by monoamine oxidases (MAO-A and B) and semicarbazide sensitive amine oxidase (SSAO) respectively has been studied in homogenates of human cystic and colonic arteries by radiochemical assays. Serotonin 19-38 amine oxidase copper containing 2 Homo sapiens 152-156 27406198-12 1998 Individual measurements of both C-peptide and insulin correlated significantly with LH 5HT turnover and VMH dopamine turnover in lean rats but not obese rats. Serotonin 87-90 insulin 2 Rattus norvegicus 32-41 9541929-6 1998 It is proposed that serotonin stimulates migration of LHRH neurons in rostral-caudal direction, and this effect of serotonin is more significant in males, since it is potentiated by testosterone. Serotonin 20-29 gonadotropin releasing hormone 1 Rattus norvegicus 54-58 9541929-6 1998 It is proposed that serotonin stimulates migration of LHRH neurons in rostral-caudal direction, and this effect of serotonin is more significant in males, since it is potentiated by testosterone. Serotonin 115-124 gonadotropin releasing hormone 1 Rattus norvegicus 54-58 9437738-1 1998 A guinea pig antibody against rabbit motilin was generated to study the localization of motilin-containing cells in the rabbit small intestine with special reference to the co-localization of motilin and serotonin. Serotonin 204-213 promotilin Oryctolagus cuniculus 37-44 9437738-8 1998 In serotonin-containing cells, immunogold particles reacted to serotonin were aggregated over the secretory granules and a large number of gold particles were scattered diffusely at the extragranular cytoplasm; however, very few or no immunogold particles were observed within the cells which reacted to motilin. Serotonin 3-12 promotilin Oryctolagus cuniculus 304-311 20595415-1 2010 OBJECTIVE: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes. Serotonin 237-246 monoamine oxidase A Homo sapiens 140-159 9515109-7 1997 Release of EDRF by the cell membrane may be mediated by G proteins sensitive to pertussis toxin (activation of the alpha 2 adrenoreceptor, serotonin, platelet aggregation, leukotrienes) or non-sensitive G proteins (adenosine-diphosphate (ADP), bradykinin). Serotonin 139-148 alpha hemoglobin stabilizing protein Homo sapiens 11-15 20630715-0 2010 Gender differences in alpha-[(11)C]MTrp brain trapping, an index of serotonin synthesis, in medication-free individuals with major depressive disorder: a positron emission tomography study. Serotonin 68-77 lysosomal protein transmembrane 4 alpha Homo sapiens 35-39 9402468-7 1997 The release of EDRF from the endothelium can be mediated by both pertussis toxin-sensitive (alpha 2-adrenoceptor activation, serotonin, aggregating platelets, leukotrienes) and insensitive (adenosine diphosphate (ADP), bradykinin) G proteins. Serotonin 125-134 alpha hemoglobin stabilizing protein Homo sapiens 15-19 9517442-10 1997 This study provides evidence suggesting that in rat CA1 pyramidal neurons, serotonin can inhibit epileptiform activity in a variety of accepted epilepsy cellular models and that inhibition of epileptiform bursts by serotonin may be mediated by activation of the 5-HT1A receptor subtype. Serotonin 75-84 carbonic anhydrase 1 Rattus norvegicus 52-55 9503561-4 1997 MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline. Serotonin 32-41 monoamine oxidase A Homo sapiens 0-5 9503561-4 1997 MAO-A preferentially deaminates serotonin (5HT) and is selectively inhibited by harmine and clorgyline, while MAO-B preferentially deaminates phenethylamine and benzylamine, and is selectively inhibited by (-)deprenyl as well as low concentrations of pargyline. Serotonin 43-46 monoamine oxidase A Homo sapiens 0-5 20642018-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Serotonin 30-39 monoamine oxidase A Homo sapiens 0-5 9392522-1 1997 Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step in the synthesis of serotonin and participates (in a non-rate-limiting fashion) in melatonin biosynthesis. Serotonin 82-91 tryptophan 5-hydroxylase 1 Oryctolagus cuniculus 0-22 20477771-3 2010 ANX/DEP ALC may be related to dopamine and serotonin, which are catalyzed by monoamine oxidase A (MAOA) and acetaldehyde dehydrogenase 2 (ALDH2). Serotonin 43-52 allantoicase Homo sapiens 8-11 9392522-1 1997 Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step in the synthesis of serotonin and participates (in a non-rate-limiting fashion) in melatonin biosynthesis. Serotonin 82-91 tryptophan 5-hydroxylase 1 Oryctolagus cuniculus 24-27 20213726-1 2010 The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. Serotonin 97-106 tryptophan hydroxylase 1 Homo sapiens 4-34 9549053-4 1997 The present studies were undertaken in order to examine whether LHRH secretion from immortalized LHRH cell lines is directly regulated by serotonin and, if so, to identify the receptor subtype involved. Serotonin 138-147 gonadotropin releasing hormone 1 Mus musculus 64-68 9549053-4 1997 The present studies were undertaken in order to examine whether LHRH secretion from immortalized LHRH cell lines is directly regulated by serotonin and, if so, to identify the receptor subtype involved. Serotonin 138-147 gonadotropin releasing hormone 1 Mus musculus 97-101 9549053-10 1997 These results demonstrate a direct stimulatory effect of serotonin on LHRH release via 5-HT7 receptor. Serotonin 57-66 gonadotropin releasing hormone 1 Mus musculus 70-74 20213726-1 2010 The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. Serotonin 97-106 tryptophan hydroxylase 1 Homo sapiens 36-40 9326303-1 1997 Tryptophan hydroxylase (TPH) catalyzes the rate-limiting and committed step in serotonin biosynthesis. Serotonin 79-88 tryptophan 5-hydroxylase 1 Oryctolagus cuniculus 0-22 20393059-0 2010 Multiple effects of serotonin and acetylcholine on hyperpolarization-activated inward current in locomotor activity-related neurons in Cfos-EGFP mice. Serotonin 20-29 FBJ osteosarcoma oncogene Mus musculus 135-139 9326303-1 1997 Tryptophan hydroxylase (TPH) catalyzes the rate-limiting and committed step in serotonin biosynthesis. Serotonin 79-88 tryptophan 5-hydroxylase 1 Oryctolagus cuniculus 24-27 9369309-3 1997 Serotonin (5-HT) injected locally at the SCN reduces light-induced glutamate release and decreases the expression of c-fos, a marker of photic transduction. Serotonin 0-9 FBJ osteosarcoma oncogene Mus musculus 117-122 20402963-6 2010 However, OCT3 was determined to be a high-capacity and low-affinity transporter for the neurotransmitters dopamine (DA), norepinephrine (NE), and serotonin (5-HT). Serotonin 146-155 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 9-13 9369342-5 1997 Here, 5-HT1A receptor activation was examined in vitro, by measuring forskolin-stimulated cAMP accumulation in HeLa cells expressing human 5-HT1A receptors, and in vivo, by using microdialysis to measure the extracellular concentration of hippocampal 5-hydroxytryptamine (5-HT) in rats. Serotonin 251-270 5-hydroxytryptamine receptor 1A Homo sapiens 6-21 9369342-5 1997 Here, 5-HT1A receptor activation was examined in vitro, by measuring forskolin-stimulated cAMP accumulation in HeLa cells expressing human 5-HT1A receptors, and in vivo, by using microdialysis to measure the extracellular concentration of hippocampal 5-hydroxytryptamine (5-HT) in rats. Serotonin 251-270 5-hydroxytryptamine receptor 1A Homo sapiens 6-12 9321821-6 1997 The increase in coronary flow seen with 10 or 100 micrograms VEGF was significantly greater than the maximal vasodilation achieved with serotonin or nitroglycerin and was equivalent to a maximal adenosine response. Serotonin 136-145 vascular endothelial growth factor A Sus scrofa 61-65 9321821-7 1997 In summary, VEGF stimulates nitric oxide (NO)-dependent dilation of coronary microvessels, and repeat administrations of VEGF resulted in rapid development of tachyphylaxis to VEGF as well as serotonin, but not to nitroglycerin or adenosine, which appeared to be secondary to impaired NO production. Serotonin 192-201 vascular endothelial growth factor A Sus scrofa 121-125 9321821-7 1997 In summary, VEGF stimulates nitric oxide (NO)-dependent dilation of coronary microvessels, and repeat administrations of VEGF resulted in rapid development of tachyphylaxis to VEGF as well as serotonin, but not to nitroglycerin or adenosine, which appeared to be secondary to impaired NO production. Serotonin 192-201 vascular endothelial growth factor A Sus scrofa 121-125 9268195-6 1997 Both BAPTA and Ro 31-8220 prevented 5HT secretion from intact platelets; however, in Ca2+-depleted, -permeable platelets, cathepsin G was able to evoke 5HT secretion and p47 phosphorylation independently of [Ca2+]i increase, both effects being hampered by Ro 31-8220. Serotonin 36-39 cathepsin G Homo sapiens 122-133 9268195-6 1997 Both BAPTA and Ro 31-8220 prevented 5HT secretion from intact platelets; however, in Ca2+-depleted, -permeable platelets, cathepsin G was able to evoke 5HT secretion and p47 phosphorylation independently of [Ca2+]i increase, both effects being hampered by Ro 31-8220. Serotonin 152-155 cathepsin G Homo sapiens 122-133 9315349-9 1997 In a co-axial bioassay system involving HUA strips denuded of endothelium and rabbit aorta with intact endothelium, HUA strips precontracted with 0.1 microM 5HT were relaxed in response to 1 microM SNP but not 1 microM carbachol, which released EDRF from the endothelium of rabbit aorta. Serotonin 157-160 alpha hemoglobin stabilizing protein Homo sapiens 245-249 9166757-1 1997 5-HT1A autoreceptor antagonists enhance the effects of antidepressants by preventing a negative feedback of serotonin (5-HT) at somatodendritic level. Serotonin 108-117 5-hydroxytryptamine receptor 1A Homo sapiens 0-6 9175891-9 1997 In contrast, ENK inhibited/hyperpolarized only 28% of serotonergic neurons; in the affected cells, the ENK effect, blocked by CTOP, had its reversal potential shifted with change of extracellular potassium in agreement with the value predicted by the Nernst equation for a potassium conductance; serotonin occluded the ENK inhibition. Serotonin 296-305 proenkephalin Rattus norvegicus 13-16 9175891-9 1997 In contrast, ENK inhibited/hyperpolarized only 28% of serotonergic neurons; in the affected cells, the ENK effect, blocked by CTOP, had its reversal potential shifted with change of extracellular potassium in agreement with the value predicted by the Nernst equation for a potassium conductance; serotonin occluded the ENK inhibition. Serotonin 296-305 proenkephalin Rattus norvegicus 103-106 9175891-9 1997 In contrast, ENK inhibited/hyperpolarized only 28% of serotonergic neurons; in the affected cells, the ENK effect, blocked by CTOP, had its reversal potential shifted with change of extracellular potassium in agreement with the value predicted by the Nernst equation for a potassium conductance; serotonin occluded the ENK inhibition. Serotonin 296-305 proenkephalin Rattus norvegicus 103-106 9103201-4 1997 Overexpression of Cbl led to inhibition of Syk and suppression of serotonin release from mast cells, demonstrating its ability to inhibit a nonreceptor tyrosine kinase. Serotonin 66-75 Cbl proto-oncogene Homo sapiens 18-21 9196609-2 1997 We aimed to evaluate in premenopausal women with abdominal obesity, (i) the hypothalamic-pituitary-adrenal (HPA) axis responses to direct pituitary stimulation with corticotrophin releasing hormone (CRH) and to opioid blockade with naloxone, and (ii) the interaction between short-term serotoninergic activation with dexfenfluramine (dF), a serotonin-release agonist, and these responses. Serotonin 286-295 corticotropin releasing hormone Homo sapiens 199-202 9120070-7 1997 We show here that amnesiac, a neurological mutation, and Dihydroxyphenylalanine decarboxylasetemperature sensitive, a mutation that interferes with synthesis of dopamine, norepinephrine, and serotonin, result in slower heart rate and reduced regularity across a normal range of temperatures for these flies. Serotonin 191-200 amnesiac Drosophila melanogaster 18-26 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Serotonin 100-109 monoamine oxidase A Homo sapiens 0-26 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Serotonin 100-109 monoamine oxidase A Homo sapiens 28-32 8960551-2 1996 Binding experiments at cloned human 5-HT(1B), 5-HT(1D), and 5-HT(1A) receptors show that all of these dimers are very potent ligands at 5-HT(1B/1D) receptors with increased binding selectivity vs the 5-HT(1A) receptor when compared to serotonin. Serotonin 235-244 5-hydroxytryptamine receptor 1A Homo sapiens 60-77 9112695-1 1996 Effects of repeated treatment with antidepressant drugs on the reactivity of CA1 neurons to 5-hydroxytryptamine (5-HT), (+/-)-8-hydroxy-2-(dipropyl-amino)-tetralin (8-OH-DPAT)--the 5-HT1A receptor agonist, and the zacopride-5-HT4 receptor agonist were examined in the rat hippocampus ex vivo. Serotonin 92-111 carbonic anhydrase 1 Rattus norvegicus 77-80 9112695-1 1996 Effects of repeated treatment with antidepressant drugs on the reactivity of CA1 neurons to 5-hydroxytryptamine (5-HT), (+/-)-8-hydroxy-2-(dipropyl-amino)-tetralin (8-OH-DPAT)--the 5-HT1A receptor agonist, and the zacopride-5-HT4 receptor agonist were examined in the rat hippocampus ex vivo. Serotonin 113-117 carbonic anhydrase 1 Rattus norvegicus 77-80 8936495-7 1996 Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release. Serotonin 138-147 interleukin 1 alpha Homo sapiens 15-19 8936495-7 1996 Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release. Serotonin 138-147 interleukin 1 alpha Homo sapiens 102-106 8936495-7 1996 Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release. Serotonin 138-147 interleukin 1 alpha Homo sapiens 102-106 8936495-7 1996 Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release. Serotonin 234-243 interleukin 1 alpha Homo sapiens 15-19 8936495-7 1996 Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release. Serotonin 234-243 interleukin 1 alpha Homo sapiens 102-106 8936495-7 1996 Interestingly, IL-1 and the VMH serotonergic system appear to be closely linked: peripherally infused IL-1 increases brain tryptophan and serotonin concentrations, while intracerebrally infused IL-1 increases neuronal firing rate and serotonin release. Serotonin 234-243 interleukin 1 alpha Homo sapiens 102-106 8936495-9 1996 IL-1 can then also act on the VHM itself, where IL-1 receptors exist, to increase its neuronal activity and serotonin release. Serotonin 108-117 interleukin 1 alpha Homo sapiens 0-4 8936495-9 1996 IL-1 can then also act on the VHM itself, where IL-1 receptors exist, to increase its neuronal activity and serotonin release. Serotonin 108-117 interleukin 1 alpha Homo sapiens 48-52 8936495-10 1996 In other words, we believe that centrally acting IL-1 increases hypothalamic neuronal firing rate and serotonin release, while peripherally acting IL-1 is critical in supplying the hypothalamus with the precursor, tryptophan, in order to maintain the high rate of serotonin synthesis. Serotonin 102-111 interleukin 1 alpha Homo sapiens 49-53 8936495-10 1996 In other words, we believe that centrally acting IL-1 increases hypothalamic neuronal firing rate and serotonin release, while peripherally acting IL-1 is critical in supplying the hypothalamus with the precursor, tryptophan, in order to maintain the high rate of serotonin synthesis. Serotonin 264-273 interleukin 1 alpha Homo sapiens 147-151 8865198-3 1996 Serotonin and serotonin agonists with relative selectivity for the receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A/2C and 5-HT3 all significantly (P < 0.01) inhibited glutamate-evoked firing of cells in the nucleus accumbens compared to the effects of an acidic saline control solution (30-60 nA, 60 s ejection currents for all). Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 85-91 8865198-3 1996 Serotonin and serotonin agonists with relative selectivity for the receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A/2C and 5-HT3 all significantly (P < 0.01) inhibited glutamate-evoked firing of cells in the nucleus accumbens compared to the effects of an acidic saline control solution (30-60 nA, 60 s ejection currents for all). Serotonin 14-23 5-hydroxytryptamine receptor 1A Homo sapiens 85-91 8880226-2 1996 In this study we report that the anti-inflammatory glucocorticoid dexamethasone (DEX) and the immunosuppressive cyclosporin A (CsA) are both effective inhibitors of SCF-induced degranulation of rat peritoneal mast cells in vitro, measured as release of serotonin (5-HT). Serotonin 253-262 KIT ligand Rattus norvegicus 165-168 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Serotonin 165-174 monoamine oxidase A Homo sapiens 24-29 8714642-9 1996 These data suggest that the 5HT effects were mediated by 5HT1A receptors. Serotonin 28-31 5-hydroxytryptamine receptor 1A Homo sapiens 57-62 8522955-0 1996 Serotonin 5-HT1D and 5-HT1A receptors respectively mediate inhibition of glutamate release and inhibition of cyclic GMP production in rat cerebellum in vitro. Serotonin 0-9 5-hydroxytryptamine receptor 1D Rattus norvegicus 10-16 9025111-0 1996 Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors. Serotonin 0-9 5-hydroxytryptamine receptor 1D Rattus norvegicus 126-132 8719928-8 1995 Immunohistochemistry revealed the presence of immunoreactive guanylin in carcinoid tissues, suggesting that these tumours co-release guanylin along with their usual resident hormone, serotonin. Serotonin 183-192 guanylate cyclase activator 2A Homo sapiens 61-69 8538158-8 1995 Pretreatment with a therapeutic concentration of SMS (10(-8) M) resulted in a significant inhibition of 5HT-stimulated electrogenic Cl- secretion (9 +/- 1 microA/cm2) (P < 0.005). Serotonin 104-107 spermine synthase Oryctolagus cuniculus 49-52 8550082-0 1995 Monocyte chemotactic protein-1 provokes mast cell aggregation and [3H]5HT release. Serotonin 70-73 C-C motif chemokine ligand 2 Rattus norvegicus 0-30 8550082-3 1995 Our data clearly show that MCP-1 (200 nM) causes a marked release of [3H]serotonin ([3H]5HT and histamine, which reach a peak at 40 min of incubation (56.6 +/- 5.3 and 34.7 +/- 6 above the control, respectively). Serotonin 73-82 C-C motif chemokine ligand 2 Rattus norvegicus 27-32 8550082-3 1995 Our data clearly show that MCP-1 (200 nM) causes a marked release of [3H]serotonin ([3H]5HT and histamine, which reach a peak at 40 min of incubation (56.6 +/- 5.3 and 34.7 +/- 6 above the control, respectively). Serotonin 88-91 C-C motif chemokine ligand 2 Rattus norvegicus 27-32 8550082-11 1995 Our report describes additional biological activities for MCP-1, suggesting for the first time that this human monocyte chemoattractant plays a fundamental role in histamine and serotonin release and cell aggregation in rat peritoneal mast cells. Serotonin 178-187 C-C motif chemokine ligand 2 Homo sapiens 58-63 8787955-0 1995 The influence of chronic administration of the serotonin agonist dexfenfluramine on responsiveness to corticotropin releasing hormone and growth hormone-releasing hormone in moderately obese people. Serotonin 47-56 corticotropin releasing hormone Homo sapiens 102-133 7671319-0 1995 Serotonin-induced calcium signaling via 5-HT1A receptors in human leukemia (K 562) cells. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 40-46 7671319-5 1995 Spiperone and NAN-190, antagonists to 5-HT1A receptor subtype, abolished the serotonin effects on calcium signaling, whereas an agonist to 5-HT1A receptor, 8OHDPAT, mimicked the serotonin-like action on the diminution of the intracellular calcium contents. Serotonin 77-86 5-hydroxytryptamine receptor 1A Homo sapiens 38-53 7671319-5 1995 Spiperone and NAN-190, antagonists to 5-HT1A receptor subtype, abolished the serotonin effects on calcium signaling, whereas an agonist to 5-HT1A receptor, 8OHDPAT, mimicked the serotonin-like action on the diminution of the intracellular calcium contents. Serotonin 178-187 5-hydroxytryptamine receptor 1A Homo sapiens 139-154 9026257-1 1995 Metergoline and 5, 7-dihydroxytryptamine were found to suppress and to prevent an electroanalgesic effect, resp. An increase in the serotonine contents in the CSF after electroanalgesia suggests an activation of the brain serotoninergic system. Serotonin 132-142 colony stimulating factor 2 Homo sapiens 159-162 8548182-0 1995 Gi proteins and the response to 5-hydroxytryptamine in porcine cultured endothelial cells with impaired release of EDRF. Serotonin 32-51 alpha hemoglobin stabilizing protein Homo sapiens 115-119 8548182-3 1995 Release of EDRF in response to 5-hydroxytryptamine (5-HT), which involves activation of pertussis toxin-sensitive Gi proteins, is impaired in both regenerated endothelium of the coronary artery following balloon catheterization and in porcine cultured endothelial cells. Serotonin 31-50 alpha hemoglobin stabilizing protein Homo sapiens 11-15 8846425-7 1995 A role for NK2 receptor stimulation has also been clearly demonstrated in bronchoconstriction induced by various agents known to induce the release of tachykinins (capsaicin, resiniferatoxin, citric acid, sodium metabisulfite diethyl ether, serotonin, and bradykinin), in allergen-induced airway constriction in the guinea pig sensitized to ovalbumin, and in hyperpnea-induced bronchoconstriction. Serotonin 241-250 substance-K receptor Cavia porcellus 11-23 7708749-2 1995 Both agonists and antagonists specific for various serotonin (5-hydroxytryptamine, 5HT) receptor subtypes interacted directly with alpha 2 beta 4 nAcChoRs: 5HT, (+/-)-8-hydroxy-2-(di-n-propylamino)tetralin, methysergide, spiperone, and ketanserin reversibly reduced the amplitude of AcCho currents and accelerated their decay. Serotonin 83-86 MGC75582, possible similarity to act2 S homeolog Xenopus laevis 131-138 7864272-0 1995 Exclusion of the 5-HT1A serotonin neuroreceptor and tryptophan oxygenase genes in a large British kindred multiply affected with Tourette"s syndrome, chronic motor tics, and obsessive-compulsive behavior. Serotonin 24-33 5-hydroxytryptamine receptor 1A Homo sapiens 17-23 7620698-0 1995 Evidence that 5-hydroxytryptamine release in rat dorsal raphe nucleus is controlled by 5-HT1A, 5-HT1B and 5-HT1D autoreceptors. Serotonin 16-33 5-hydroxytryptamine receptor 1B Rattus norvegicus 95-101 7891145-1 1995 We investigated whether interleukin-1 (IL-1) activity in the rat hypothalamus was increased by immobilization stress (IS), and whether pretreatment with an interleukin-1 receptor antagonist (IL-1Ra) is capable of inhibiting IS-induced elevations of hypothalamic norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and the levels of their metabolites as well as of plasma adrenocorticotropic hormone (ACTH). Serotonin 302-311 interleukin 1 receptor antagonist Rattus norvegicus 156-189 7891145-1 1995 We investigated whether interleukin-1 (IL-1) activity in the rat hypothalamus was increased by immobilization stress (IS), and whether pretreatment with an interleukin-1 receptor antagonist (IL-1Ra) is capable of inhibiting IS-induced elevations of hypothalamic norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and the levels of their metabolites as well as of plasma adrenocorticotropic hormone (ACTH). Serotonin 302-311 interleukin 1 receptor antagonist Rattus norvegicus 191-197 7736561-0 1995 Serotonin elevates intracellular Ca2+ in rat choroid plexus epithelial cells by acting on 5-HT2C receptors. Serotonin 0-9 5-hydroxytryptamine receptor 2C Rattus norvegicus 90-96 7583341-3 1995 Fluoxetine appears to act on a different subtype of receptor (the 5-HT2C receptor [in original terminology the 5-HT1C receptor]) than the one on which micromolar concentrations of serotonin are known to act in astrocytes (the 5-HT2A receptor [in original terminology the 5-HT2 receptor]). Serotonin 180-189 5-hydroxytryptamine receptor 2C Homo sapiens 111-117 7890297-5 1995 Both expression of IL-2R and proliferation in response to Con A by spleen cells from serotonin-depleted mice were increased or completely restored by supplementation of the cultures with serotonin. Serotonin 85-94 interleukin 2 receptor, alpha chain Mus musculus 19-24 7890297-5 1995 Both expression of IL-2R and proliferation in response to Con A by spleen cells from serotonin-depleted mice were increased or completely restored by supplementation of the cultures with serotonin. Serotonin 187-196 interleukin 2 receptor, alpha chain Mus musculus 19-24 7724701-2 1995 Both serotonin (5-HT) releasers and agonists at 5-HT1A, 5-HT1B, and 5-HT2 receptors reduce PPI in the rat. Serotonin 5-14 5-hydroxytryptamine receptor 1B Rattus norvegicus 56-62 7889278-3 1994 In this study we have examined the effects of the specific PKC inhibitors Ro31-8220 and Ro31-7549 and the non-specific inhibitor H7 on carbachol-, 5-hydroxytryptamine (5-HT)- and 4 beta-phorbol dibutyrate (4 beta-PDBu)-induced contractions in large and small bronchioles. Serotonin 147-166 protein kinase C, gamma Rattus norvegicus 59-62 7814348-7 1994 CONCLUSION: The hypothesis that trazodone corrects behavioral and affective disturbance induced by serotonin depletion in DAT requires confirmation in a double-blind placebo-controlled trial. Serotonin 99-108 solute carrier family 6 member 3 Homo sapiens 122-125 7965075-9 1994 Low levels of serotonin immunoreactivity are detected in differentiated RN46A cells, and this was potentiated by differentiating RN46A cells with BDNF for 8 d and 40 mM KCl for days 4-8. Serotonin 14-23 brain-derived neurotrophic factor Rattus norvegicus 146-150 7519657-8 1994 Compared with vehicle, BDNF increased striatal levels of homovanillic acid (HVA; 86%), 3,4-dihydroxyphenylacetic acid (DOPAC; 42%), and 5-hydroxyindoleacetic acid (5-HIAA; 32%) and the HVA/DA (43%) and 5-HIAA/serotonin (34%) ratios in the DA-denervated striatum. Serotonin 209-218 brain-derived neurotrophic factor Rattus norvegicus 23-27 20534514-5 2010 Mice expressing RGS-insensitive G(alpha)i2 also exhibited increased cortical and hippocampal phosphorylation of glycogen synthase kinase-3beta, a constitutively active proapoptotic kinase that is inhibited through phosphorylation in response to serotonin, SSRIs, and 5-HT1 receptor agonists. Serotonin 245-254 glycogen synthase kinase 3 beta Mus musculus 112-142 7525113-3 1994 The effect of postnatal handling on glucocorticoid receptor expression appears to be mediated by an increase in serotonin (5-HT) activity, acting via a 5-HT2 receptor with a high affinity for 5-HT (i.e. the 5-HT2H receptor). Serotonin 112-121 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 36-59 8090811-0 1994 ICV injection of the serotonin 5-HT1B agonist CP-93,129 increases the secretion of ACTH, prolactin, and renin and increases blood pressure by nonserotonergic mechanisms. Serotonin 21-30 5-hydroxytryptamine receptor 1B Rattus norvegicus 31-37 8090811-1 1994 This study tested whether a new serotonin (5-HT1B) agonist, 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxy-pyrrolo[3,2-b]pyridine (CP-93,129), could be used to study the potential role of 5-HT1B receptors in the secretion of adrenocorticotropic hormone (ACTH), prolactin, and renin. Serotonin 32-41 5-hydroxytryptamine receptor 1B Rattus norvegicus 43-49 8090811-1 1994 This study tested whether a new serotonin (5-HT1B) agonist, 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxy-pyrrolo[3,2-b]pyridine (CP-93,129), could be used to study the potential role of 5-HT1B receptors in the secretion of adrenocorticotropic hormone (ACTH), prolactin, and renin. Serotonin 32-41 5-hydroxytryptamine receptor 1B Rattus norvegicus 184-190 20633104-5 2010 Activation of IDO shifts TRY metabolism from serotonin synthesis to formation of "kynurenines." Serotonin 45-54 indoleamine 2,3-dioxygenase 1 Homo sapiens 14-17 7855226-1 1994 Previous studies with direct-acting serotonin (5-HT) agonists and antagonists have demonstrated that stimulation of 5-HT1A, 5-HT1C and 5-HT2 receptors may promote cortisol and prolactin (PRL) secretion in man. Serotonin 36-45 5-hydroxytryptamine receptor 2C Homo sapiens 124-130 8028479-1 1994 Because of their similarities, serotonin 5-HT2, 5-HT1C, and the recently described 5-HT2F receptors have been classified as members of the 5-HT2 receptor family, and they have been renamed 5-HT2A, 5-HT2C and 5-HT2B, respectively. Serotonin 31-40 5-hydroxytryptamine receptor 2C Rattus norvegicus 197-203 20518729-7 2010 These lines of evidences encourage us to design new generation 5-HT(1A) ligands such as 5-HT(1A) agonists with greater potency, higher selectivity and improved pharmacokinetic properties, and 5-HT(1A) ligands which combine multiple pharmacological actions (e.g., inhibition of serotonin transporter, dopamine D(2) receptors and other 5-HT receptor subtypes). Serotonin 63-67 5-hydroxytryptamine receptor 1A Homo sapiens 88-95 8018847-3 1994 Application of exogenous 5-hydroxytryptamine (5-HT) directly to the substantia nigra similarly enhanced release of AChE, whilst local application of cinanserin, a 5-HT antagonist, inhibited electrically-evoked release. Serotonin 25-44 acetylcholinesterase Cavia porcellus 115-119 8016407-1 1994 It has been proposed that there might be a link between the anorectic actions of cholecystokinin (CCK) and serotonin (5HT). Serotonin 107-116 cholecystokinin Rattus norvegicus 81-96 20518729-7 2010 These lines of evidences encourage us to design new generation 5-HT(1A) ligands such as 5-HT(1A) agonists with greater potency, higher selectivity and improved pharmacokinetic properties, and 5-HT(1A) ligands which combine multiple pharmacological actions (e.g., inhibition of serotonin transporter, dopamine D(2) receptors and other 5-HT receptor subtypes). Serotonin 63-67 5-hydroxytryptamine receptor 1A Homo sapiens 88-95 8016407-1 1994 It has been proposed that there might be a link between the anorectic actions of cholecystokinin (CCK) and serotonin (5HT). Serotonin 107-116 cholecystokinin Rattus norvegicus 98-101 8016407-1 1994 It has been proposed that there might be a link between the anorectic actions of cholecystokinin (CCK) and serotonin (5HT). Serotonin 118-121 cholecystokinin Rattus norvegicus 81-96 7984293-1 1994 Specific binding for the serotonin 5-HT4 receptor (5-HT4R) radioligand [3H]GR 113808 was identified in pig caudate nucleus and characterized by serotonin subtype selective drugs. Serotonin 25-34 5-hydroxytryptamine receptor 4 Sus scrofa 51-57 7984293-2 1994 Binding was inhibited by serotonin and by synthetic indoles, benzamides and benzimidazolones known to characterize the 5-HT4R in functional tests. Serotonin 25-34 5-hydroxytryptamine receptor 4 Homo sapiens 119-125 7984293-5 1994 Rank order of potency of 5-HT4R agonists was: SC 53116 (Ki, 21 nM) > BIMU 1 > cisapride > BIMU 8 > serotonin > renzapride > S-zacopride > metoclopramide > R-zacopride > 5-methoxytryptamine >> 5-carboxamidotryptamine. Serotonin 111-120 5-hydroxytryptamine receptor 4 Homo sapiens 25-31 7912195-1 1994 The action of serotonin on growth hormone (GH) secretion is controversial because of interspecies differences and lack of specificity of serotoninergic drugs. Serotonin 14-23 somatotropin Ovis aries 27-41 7912195-1 1994 The action of serotonin on growth hormone (GH) secretion is controversial because of interspecies differences and lack of specificity of serotoninergic drugs. Serotonin 14-23 somatotropin Ovis aries 43-45 7912195-2 1994 Serotonin (5-HT) appears to inhibit GH release in the sheep and in man. Serotonin 0-9 somatotropin Ovis aries 36-38 7902421-2 1993 Tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) catalyze the rate-limiting steps in dopamine and serotonin biosynthesis, respectively, and are the subject of dynamic regulatory mechanisms that could be sensitive to the actions of cocaine. Serotonin 108-117 tryptophan hydroxylase 1 Rattus norvegicus 30-52 20592043-3 2010 Genetic association studies suggest that variation within the genes of central neurotransmitter systems, particularly the serotonin (5-HTTLPR, MAOA-uVNTR) and opioid (OPRM1 A118G), are associated with individual differences in social sensitivity, which reflects the degree of emotional responsivity to social events and experiences. Serotonin 122-131 monoamine oxidase A Homo sapiens 143-147 7902421-2 1993 Tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) catalyze the rate-limiting steps in dopamine and serotonin biosynthesis, respectively, and are the subject of dynamic regulatory mechanisms that could be sensitive to the actions of cocaine. Serotonin 108-117 tryptophan hydroxylase 1 Rattus norvegicus 54-57 8245704-1 1993 A peptide homologous to a region of murine granulocyte-macrophage colony-stimulating factor (mGM-CSF), P27-38, which was shown to be a GM-CSF antagonist, inhibited the function of serotonin release from murine mast cells. Serotonin 180-189 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 94-100 8245704-5 1993 The inhibitory effect of P27-38 and the neutralizing antibodies on serotonin release could be reversed by the addition of exogenous GM-CSF to the stimulated mast cells, indicating that the inhibitory activity was probably due to an effect on endogenously produced GM-CSF. Serotonin 67-76 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 132-138 8245704-5 1993 The inhibitory effect of P27-38 and the neutralizing antibodies on serotonin release could be reversed by the addition of exogenous GM-CSF to the stimulated mast cells, indicating that the inhibitory activity was probably due to an effect on endogenously produced GM-CSF. Serotonin 67-76 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 264-270 20443629-0 2010 The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists. Serotonin 86-95 5-hydroxytryptamine receptor 1A Homo sapiens 96-102 8274274-2 1993 Here, we show that the modulation of this current by norepinephrine, serotonin, and histamine is mediated by protein kinase A in hippocampal CA1 neurons. Serotonin 69-78 carbonic anhydrase 1 Homo sapiens 141-144 8265809-8 1993 These data suggest that a serotonergic influence on CNS IGF-II exists and that IGF-II secretion may be altered by factors affecting serotonin metabolism or efficacy. Serotonin 132-141 insulin-like growth factor 2 Rattus norvegicus 79-85 7905821-7 1993 Pharmacological investigations with these ligands revealed that serotonin is probably involved in the behavioural disorders associated with schizophrenia through its binding to three distinct classes of receptors: 5-HT1A, 5-HT2 (or the closely related class 5-HT1C) and 5-HT3. Serotonin 64-73 5-hydroxytryptamine receptor 2C Homo sapiens 258-264 20159029-2 2010 Searching for a correlation between them, we estimated serum total cholesterol and CSF levels of the main serotonin metabolite 5-HIAA in medication free male and female subjects for whom diagnostic lumbar puncture was performed. Serotonin 106-115 colony stimulating factor 2 Homo sapiens 83-86 8401931-2 1993 [3H]-5-hydroxytryptamine (5-HT) has been shown to radiolabel at least five types of 5-HT binding sites in mammalian brain tissue, 5-HT1A, 5-HT1C, 5-HT1D and 5-HT1D and 5-HT1E (Frazer et al., 1990). Serotonin 5-24 5-hydroxytryptamine receptor 2C Homo sapiens 138-144 8401931-2 1993 [3H]-5-hydroxytryptamine (5-HT) has been shown to radiolabel at least five types of 5-HT binding sites in mammalian brain tissue, 5-HT1A, 5-HT1C, 5-HT1D and 5-HT1D and 5-HT1E (Frazer et al., 1990). Serotonin 5-24 5-hydroxytryptamine receptor 1D Homo sapiens 146-152 8401931-2 1993 [3H]-5-hydroxytryptamine (5-HT) has been shown to radiolabel at least five types of 5-HT binding sites in mammalian brain tissue, 5-HT1A, 5-HT1C, 5-HT1D and 5-HT1D and 5-HT1E (Frazer et al., 1990). Serotonin 5-24 5-hydroxytryptamine receptor 1D Homo sapiens 157-163 20556201-1 2010 Trytophan Hydroxylase Type I (TPH1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. Serotonin 121-130 tryptophan hydroxylase 1 Homo sapiens 30-34 8407286-5 1993 Moreover, the release of [3H]serotonin from IgE-sensitized mast cells showed a time-course more rapid than PAF production and occurred in cells sensitized with IgE at concentrations lower than those required for PAF formation. Serotonin 29-38 PCNA clamp associated factor Rattus norvegicus 212-215 8395390-4 1993 injection of PAF (1 microgram/cavity) (ED50 = 6.1 mg/kg), partially (42% reduction) the one induced by serotonin (100 micrograms/cavity), but was inactive against histamine (200 micrograms/cavity) or bradykinin (50 micrograms/cavity). Serotonin 103-112 PCNA clamp associated factor Rattus norvegicus 13-16 20556201-2 2010 We have previously described three series of novel, periphery-specific TPH1 inhibitors that selectively deplete serotonin in the gastrointestinal tract. Serotonin 112-121 tryptophan hydroxylase 1 Homo sapiens 71-75 20059554-1 2010 Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal serotonin and is linked to numerous behavioral traits. Serotonin 53-62 tryptophan hydroxylase 2 Macaca mulatta 0-24 8214611-1 1993 Serotonin-synthesizing neurons in the retina of Xenopus laevis have been identified using anti-phenylalanine hydroxylase (PH) antibody which recognizes tryptophan 5-hydroxylase, the rate-limiting enzyme for serotonin synthesis. Serotonin 0-9 tryptophan hydroxylase 1 L homeolog Xenopus laevis 152-176 8214611-1 1993 Serotonin-synthesizing neurons in the retina of Xenopus laevis have been identified using anti-phenylalanine hydroxylase (PH) antibody which recognizes tryptophan 5-hydroxylase, the rate-limiting enzyme for serotonin synthesis. Serotonin 207-216 tryptophan hydroxylase 1 L homeolog Xenopus laevis 152-176 8382263-0 1993 Release-regulating serotonin 5-HT1D autoreceptors in human cerebral cortex. Serotonin 19-28 5-hydroxytryptamine receptor 1D Homo sapiens 29-35 8382263-1 1993 Release-regulating 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain belong to the 5-HT1B subtype. Serotonin 19-38 5-hydroxytryptamine receptor 1B Rattus norvegicus 91-97 8444354-1 1993 Molecular cloning studies have now identified six HTR genes encoding the biosynthesis of the structurally homologous human serotonin (5-hydroxytryptamine; 5-HT) receptors, namely 5-HTR1A, 5-HTR1B, 5-HTR1C, 5-HTR1D, 5-HTR2 and 5-HTRS31. Serotonin 123-132 5-hydroxytryptamine receptor 2C Homo sapiens 199-204 8444354-1 1993 Molecular cloning studies have now identified six HTR genes encoding the biosynthesis of the structurally homologous human serotonin (5-hydroxytryptamine; 5-HT) receptors, namely 5-HTR1A, 5-HTR1B, 5-HTR1C, 5-HTR1D, 5-HTR2 and 5-HTRS31. Serotonin 134-153 5-hydroxytryptamine receptor 2C Homo sapiens 199-204 20059554-1 2010 Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal serotonin and is linked to numerous behavioral traits. Serotonin 53-62 tryptophan hydroxylase 2 Macaca mulatta 26-30 20210853-1 2010 Serotonin N-acetyltransferase (AANAT) catalyzes the conversion of serotonin to N-acetylserotonin, which is the immediate precursor for formation of melatonin. Serotonin 66-75 aralkylamine N-acetyltransferase Rattus norvegicus 0-29 8462655-1 1993 Serotonin-synthesizing neurons in the retinas of goldfish, axolotl, turtle, chick, rabbit and cat were identified using double labelling with anti-serotonin and anti-phenylalanine hydroxylase antibodies. Serotonin 0-9 phenylalanine-4-hydroxylase Oryctolagus cuniculus 166-191 7680801-2 1993 The subcortical innervation of a recently described subpopulation of non-pyramidal neurons, containing the calcium binding protein, calretinin, was investigated in the rat hippocampus using the anterograde tracer Phaseolus vulgaris-leucoagglutinin and double immunocytochemistry for calretinin and serotonin at the light and electron microscopic levels. Serotonin 298-307 calbindin 2 Rattus norvegicus 132-142 20210853-1 2010 Serotonin N-acetyltransferase (AANAT) catalyzes the conversion of serotonin to N-acetylserotonin, which is the immediate precursor for formation of melatonin. Serotonin 66-75 aralkylamine N-acetyltransferase Rattus norvegicus 31-36 20403031-0 2010 Immunostaining of gastric cancer with neuroendocrine differentiation: Reg IV-positive neuroendocrine cells are associated with gastrin, serotonin, pancreatic polypeptide and somatostatin. Serotonin 136-145 regenerating family member 4 Homo sapiens 70-76 8310791-0 1993 p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. Serotonin 25-34 glial fibrillary acidic protein Rattus norvegicus 80-111 8310791-12 1993 The results indicate that serotonin influences the increase of GFAP immunoreactivity following spinal cord injury either directly or indirectly, for instance by its microvascular reactions. Serotonin 26-35 glial fibrillary acidic protein Rattus norvegicus 63-67 8221154-1 1993 This study tested the effect of brain serotonin (5-HT) depletion on the secretion of oxytocin (OT), vasopressin (VP), and adrenocorticotropin (ACTH) due to an osmotic load. Serotonin 38-47 oxytocin/neurophysin I prepropeptide Homo sapiens 85-93 1289916-5 1992 Since a steep ASF slope seems to indicate low central serotonergic function, it is speculated that a steep ASF slope characterizes those patients with a serotonin deficit who respond to serotonin agonists like lithium. Serotonin 153-162 arylsulfatase F Homo sapiens 107-110 1390897-4 1992 The later stage of platelet adhesion was inhibited by an antibody against the GPIIb/IIIa complex and a concomitant release of 14C-labeled serotonin was observed. Serotonin 138-147 integrin subunit alpha 2b Homo sapiens 78-83 20403031-6 2010 In 205 cases with NE differentiation, Reg IV-positive cases expressed serotonin (P= 0.0032) and somatostatin (P= 0.036) more frequently than Reg IV-negative cases. Serotonin 70-79 regenerating family member 4 Homo sapiens 38-44 20403031-7 2010 Double immunofluorescence staining revealed co-expression of Reg IV with gastrin, serotonin and PP. Serotonin 82-91 regenerating family member 4 Homo sapiens 61-67 1403796-1 1992 5-hydroxytryptamine (5-HT) hyperpolarizes hippocampal pyramidal cells in both areas CA1 and CA3 through an increase in potassium conductance. Serotonin 0-19 carbonic anhydrase 1 Homo sapiens 84-87 20384866-11 2010 Additionally, inhibition of phosphoinositol-3-kinase (PI3K) with wortmannin only had a partial effect on serotonin signaling, despite the fact that the concentrations used completely abolished phagocytic signaling. Serotonin 105-114 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Rattus norvegicus 28-52 1505525-9 1992 After expression of this receptor in Xenopus oocytes, the application of serotonin triggered the typical chloride current which presumably results from the activation of phospholipase C. The coupling to this response system was less efficient than that of the 5-HT1C or 5-HT2 receptors. Serotonin 73-82 5-hydroxytryptamine receptor 2C Rattus norvegicus 260-266 1356432-6 1992 These studies indicate that, in addition to the dopamine system, the norepinephrine and serotonin systems also play prominent roles in the activation of zif268 and c-fos by cocaine and amphetamine. Serotonin 88-97 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 164-169 20144688-2 2010 Although a genetic association of tryptophan hydroxylase isoform 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform TPH2 is more relevant to the central nervous system and the association of TPH2 gene with schizophrenia has been much less explored. Serotonin 103-112 tryptophan hydroxylase 1 Homo sapiens 34-66 1390395-7 1992 Both large SLI and 5,7-DHT-accumulating amacrine cells in Xenopus and Bufo were labeled with an antibody raised against phenylalanine hydroxylase (PH), which binds to tryptophan 5-hydroxylase, one of the synthesizing enzymes for serotonin. Serotonin 229-238 tryptophan hydroxylase 1 L homeolog Xenopus laevis 167-191 1281015-7 1992 The serotonin level in GpF was significantly lower at 5 min of CPB than in GpC. Serotonin 4-13 glycophorin C (Gerbich blood group) Homo sapiens 75-78 20144688-2 2010 Although a genetic association of tryptophan hydroxylase isoform 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform TPH2 is more relevant to the central nervous system and the association of TPH2 gene with schizophrenia has been much less explored. Serotonin 103-112 tryptophan hydroxylase 1 Homo sapiens 68-72 20006676-3 2010 Neuroanatomical mapping of conventional Ca(2+)-sensitive PKC53E activity uncovers a previously uncharacterized role of Drosophila serotonin neurons in alcohol sensitivity. Serotonin 130-139 Protein C kinase 53E Drosophila melanogaster 57-63 1399685-0 1992 Synthesis and biodistribution of a new radiotracer for in vivo labeling of serotonin uptake sites by PET, cis-N,N-[11C]dimethyl-3-(2",4"-dichlorophenyl)-indanamine (cis-[11C]DDPI). Serotonin 75-84 thyroid stimulating hormone receptor Mus musculus 101-104 1399685-1 1992 A new PET radiotracer for in vivo labeling of serotonin (5-HT) uptake sites, cis-N,N-[11C]dimethyl-3-(2",4"-dichlorophenyl)-indanamine, cis-[11C]DDPI, was synthesized and its biological behavior was studied. Serotonin 46-55 thyroid stimulating hormone receptor Mus musculus 6-9 1399685-1 1992 A new PET radiotracer for in vivo labeling of serotonin (5-HT) uptake sites, cis-N,N-[11C]dimethyl-3-(2",4"-dichlorophenyl)-indanamine, cis-[11C]DDPI, was synthesized and its biological behavior was studied. Serotonin 57-61 thyroid stimulating hormone receptor Mus musculus 6-9 1360291-0 1992 Relationship between brain serotonin and calmodulin in young, genetically obese (ob/ob) mice. Serotonin 27-36 calmodulin 2 Mus musculus 41-51 1360291-6 1992 Regardless of age and sex, brain serotonin was positively correlated to the brain calmodulin in the lean mice (r = 0.559, p < 0.01), yet this was not found in obese mice. Serotonin 33-42 calmodulin 2 Mus musculus 82-92 1360291-9 1992 The results also suggest that abnormal brain serotonin synthesis in obese mouse regulated by calmodulin might interact with certain factors, such as calcium ions, to complete the activation of serotonin-synthesized enzymes in the development of obesity. Serotonin 45-54 calmodulin 2 Mus musculus 93-103 20006676-4 2010 The deficiency of PKC53E but not novel Ca(2+)-independent PKC98E appears to reduce synaptic serotonin levels, since acute inhibition of serotonin reuptake by citalopram and Prozac reversed alcohol insensitivity in flies expressing PKC53E double-stranded RNA in serotonin neurons. Serotonin 92-101 Protein C kinase 53E Drosophila melanogaster 18-24 1360291-9 1992 The results also suggest that abnormal brain serotonin synthesis in obese mouse regulated by calmodulin might interact with certain factors, such as calcium ions, to complete the activation of serotonin-synthesized enzymes in the development of obesity. Serotonin 193-202 calmodulin 2 Mus musculus 93-103 20006676-4 2010 The deficiency of PKC53E but not novel Ca(2+)-independent PKC98E appears to reduce synaptic serotonin levels, since acute inhibition of serotonin reuptake by citalopram and Prozac reversed alcohol insensitivity in flies expressing PKC53E double-stranded RNA in serotonin neurons. Serotonin 136-145 Protein C kinase 53E Drosophila melanogaster 18-24 20006676-4 2010 The deficiency of PKC53E but not novel Ca(2+)-independent PKC98E appears to reduce synaptic serotonin levels, since acute inhibition of serotonin reuptake by citalopram and Prozac reversed alcohol insensitivity in flies expressing PKC53E double-stranded RNA in serotonin neurons. Serotonin 136-145 Protein C kinase 53E Drosophila melanogaster 18-24 20006676-5 2010 Together, findings from this and our previous studies indicate that PKC53E and PKC98E differentially regulate fly alcohol sensitivity through independent modulation of conserved serotonin and neuropeptide Y-like systems. Serotonin 178-187 Protein C kinase 53E Drosophila melanogaster 68-74 1351684-3 1992 Membranes prepared from CHO cells stably expressing the receptor bound [3H]serotonin with high affinity (Kd 4 nM) and displayed a pharmacological profile consistent, but not identical, with that of the characterized serotonin 5HT1D receptor. Serotonin 75-84 5-hydroxytryptamine receptor 1D Homo sapiens 226-231 20036056-0 2010 Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. Serotonin 68-77 prepronociceptin Rattus norvegicus 0-10 1351684-7 1992 The existence of multiple neuronal 5HT1D-like receptors may help account for some of the complexities associated with [3H]serotonin binding patterns in native membranes. Serotonin 122-131 5-hydroxytryptamine receptor 1D Homo sapiens 35-40 1379825-3 1992 Serotonin-immunoreactive paraneurons were first detected in the pulmonary mesenchyma of 8-day-old embryos, while in the 12-day-old embryos the following neurons and paraneurons were first detected in their respective locations: serotonin-immunoreactive paraneurons in the bronchial epithelium; VIP- and galanin-immunoreactive ganglionic cells and SP-immunoreactive nerve fibres in the intrapulmonary ganglia. Serotonin 0-9 galanin and GMAP prepropeptide Gallus gallus 303-310 20036056-0 2010 Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats. Serotonin 68-77 prepronociceptin Rattus norvegicus 11-22 20396435-0 2010 Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population. Serotonin 20-29 tryptophan hydroxylase 1 Homo sapiens 62-66 1733778-4 1992 Expression of this receptor in murine Ltk- cells conferred upon these cells the ability to respond to serotonin by inhibition of adenylyl cyclase. Serotonin 102-111 leukocyte tyrosine kinase Mus musculus 38-41 19932741-5 2010 The levels of hippocampal serotonin (5-HT) and its main metabolite, 5-hydroxyindoleacetic acid (5-HIAA), were significantly lower in Mecp2-null mice than in age-matched wild-type mice on P28, P42 and P56. Serotonin 26-35 methyl CpG binding protein 2 Mus musculus 133-138 1534765-7 1992 On the basis of the similarities between the inhibitory effects of serotonin and TFMPP, the present results further support the idea that endogenous serotonin acts via the stimulation of 5-HT1B receptors to inhibit male sexual behaviour. Serotonin 149-158 5-hydroxytryptamine receptor 1B Rattus norvegicus 187-193 19900455-2 2010 Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal serotonin and is closely related to the hypothalamic-pituitary-adrenal (HPA) axis, while early life experience is a critical environmental factor programming the HPA axis response to stress. Serotonin 53-62 tryptophan hydroxylase 2 Macaca mulatta 0-24 1582705-5 1992 It thus seems as if the inhibiting effect of serotonin on T lymphocytes is mediated by 5-HT1c or 5-HT2 receptors, while the mechanism for the intrinsic inhibiting effect of the antagonists at present is unknown. Serotonin 45-54 5-hydroxytryptamine receptor 2C Homo sapiens 87-93 1732716-1 1992 The relationship between the serotonin 5-hydroxytryptamine1B (5-HT1B) and 5-HT1D receptors has been the topic of much investigation and speculation since their complementary species distribution was first appreciated. Serotonin 29-38 5-hydroxytryptamine receptor 1B Rattus norvegicus 62-68 1741773-8 1991 The ratio, MAO A molecular activity:MAO B molecular activity decreased in the order: serotonin (35:1) greater than tryptamine (12:1) greater than tyramine (3.3:1) greater than dopamine (2.4:1) greater than benzylamine (1:23). Serotonin 85-94 monoamine oxidase B Homo sapiens 36-41 19900455-2 2010 Tryptophan hydroxylase-2 (TPH2) synthesizes neuronal serotonin and is closely related to the hypothalamic-pituitary-adrenal (HPA) axis, while early life experience is a critical environmental factor programming the HPA axis response to stress. Serotonin 53-62 tryptophan hydroxylase 2 Macaca mulatta 26-30 19747494-1 2010 The effects of nociceptin/orphanin FQ on putative serotonin (5HT) neurons of the dorsal raphe nucleus (DRN), known to modulate the behavioral responses to stress, were investigated in vivo and in vitro. Serotonin 50-59 prepronociceptin Rattus norvegicus 15-25 1920135-1 1991 DOI [(+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCI] is a serotonin (5-HT1C/5-HT2) agonist, with potent cardiovascular effects. Serotonin 67-76 5-hydroxytryptamine receptor 2C Rattus norvegicus 78-84 19747494-1 2010 The effects of nociceptin/orphanin FQ on putative serotonin (5HT) neurons of the dorsal raphe nucleus (DRN), known to modulate the behavioral responses to stress, were investigated in vivo and in vitro. Serotonin 61-64 prepronociceptin Rattus norvegicus 15-25 19747494-13 2010 Together, these findings suggest that CRF and the nociceptin/orphanin FQ/NOP system interact in the DRN during stress to control 5HT transmission; this may play a role in stress-related neuropsychopathologies. Serotonin 129-132 prepronociceptin Rattus norvegicus 50-60 19747494-13 2010 Together, these findings suggest that CRF and the nociceptin/orphanin FQ/NOP system interact in the DRN during stress to control 5HT transmission; this may play a role in stress-related neuropsychopathologies. Serotonin 129-132 prepronociceptin Rattus norvegicus 61-72 1666183-6 1991 Furthermore, the effects of NT on plasma LTC4 and hematocrit were reduced by pretreating animals with antagonists to histamine and serotonin. Serotonin 131-140 neurotensin Rattus norvegicus 28-30 21033078-8 2010 CONCLUSIONS: In patients with MO FB hormone levels (Leptin, Ghrelin) elevated to normal values, reduced levels of serotonin, there is an infringement of their reciprocal correlations. Serotonin 114-123 leptin Homo sapiens 52-58 1888687-8 1991 In more recent years, using a hippocampal cell culture system, we have provided evidence for the importance of serotonin-induced changes in cAMP levels in mediating the effect of postnatal handling on hippocampal glucocorticoid receptor density. Serotonin 111-120 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 213-236 19541671-0 2009 Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptake. Serotonin 0-9 coagulation factor III, tissue factor Homo sapiens 97-110 1893246-1 1991 The distribution and levels of glial fibrillary acidic protein (GFAP) were determined in the adult rat hypothalamus following axotomy of serotonin (5-HT) neurons. Serotonin 137-146 glial fibrillary acidic protein Rattus norvegicus 64-68 1710012-2 1991 Serotonin caused a 15% increase in POMC mRNA levels, an effect which was blocked by the 5-HT2 receptor antagonist ketanserin. Serotonin 0-9 proopiomelanocortin Rattus norvegicus 35-39 19808015-1 2009 In a paper by Yadav and colleagues, a novel pathway linking the central nervous system effects of leptin on bone mass and energy expenditure to serotonin signaling in brainstem circuits is described. Serotonin 144-153 leptin Homo sapiens 98-104 1710012-6 1991 It is concluded that serotonin exerts a positive control and dopamine a negative control on POMC mRNA concentrations in primary cultures of rat hypothalamic neurons. Serotonin 21-30 proopiomelanocortin Rattus norvegicus 92-96 1905236-0 1991 Serotonin-induced renin release in the dog kidney. Serotonin 0-9 renin Canis lupus familiaris 18-23 1905236-1 1991 The effect of serotonin (5-HT) on renin release was examined in denervated kidney of the pentobarbital-anesthetized dog. Serotonin 14-23 renin Canis lupus familiaris 34-39 2004780-4 1991 The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism. Serotonin 131-140 tryptophan 2,3-dioxygenase Homo sapiens 4-24 19654143-6 2009 Serotonin suppressed milk protein mRNA expression (alpha-lactalbumin and beta-casein mRNA) in lactogen-treated primary bovine mammary epithelial cell (BMEC) cultures. Serotonin 0-9 lactalbumin alpha Bos taurus 51-68 1883989-5 1991 Thus, GR may play a role in the maturation of these hypothalamic nuclei and the 5-hydroxytryptamine and noradrenaline neurons, and GR may provide a basis for the ability of stress-induced increases of glucocorticoids to influence distinct brain circuits during postnatal development. Serotonin 80-99 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 6-8 19607848-6 2009 MAPKK1 and PP-1G are known 5-HT(1A) R-dependent signaling compounds and are in agreement with receptor knock-out and septin-5 is involved in serotonin transport, although regulation by 5-HT(1A) R has not been reported. Serotonin 141-150 septin 5 Mus musculus 117-125 2289525-0 1990 Endothelin-1 increases arterial sensitivity to 5-hydroxytryptamine. Serotonin 47-66 endothelin-1 Oryctolagus cuniculus 0-12 19718454-7 2009 We demonstrate that AZIN2 localizes in the Vamp-8 positive, serotonin-containing subset of MC granules, but not in tryptase-containing granules, as revealed by double immunofluorescence stainings. Serotonin 60-69 antizyme inhibitor 2 Homo sapiens 20-25 2387654-2 1990 The aggregation was inhibited with a KI-value of 8.8 microM and the 5HT uptake in a noncompetitive way with KI1 = 15.3 microM and K12 = 10.6 microM. Serotonin 68-71 TNF receptor superfamily member 8 Homo sapiens 108-111 19718454-11 2009 The granule subtype-specific expression and its induction after MC activation suggest a role for AZIN2 as a local, in situ regulator of polyamine biosynthesis in association with serotonin-containing granules of MCs. Serotonin 179-188 antizyme inhibitor 2 Homo sapiens 97-102 19664204-3 2009 Here we have tested if this hypothesis applies to other pain states by using a combination of approaches in a rat model of osteoarthritis (OA) to ascertain if 1) a role for descending 5HT mediated facilitation exists, and 2) if pregabalin (a newer analogue of gabapentin) is an effective antinociceptive agent in this model. Serotonin 184-187 ATP synthase inhibitory factor subunit 1 Rattus norvegicus 156-160 2196436-5 1990 Using three ligands with high affinity at the 5HT1C receptor, LY53857, ritanserin, and SCH23390, the contractile response to serotonin was inhibited by all three ligands. Serotonin 125-134 5-hydroxytryptamine receptor 2C Rattus norvegicus 46-51 19278673-9 2009 CONCLUSIONS: Higher 5-HT1A BP(F) in bipolar depressed males suggests higher raphe autoreceptor binding, potentially causing less serotonin release and compensatory upregulation of forebrain postsynaptic 5-HT1A receptors. Serotonin 129-138 5-hydroxytryptamine receptor 1A Homo sapiens 20-26 2357926-0 1990 [Changes in the level of regulatory peptides and serotonin in the hippocampus of opiate-dependent animals treated with oxytocin]. Serotonin 49-58 oxytocin/neurophysin I prepropeptide Homo sapiens 119-127 19524439-2 2009 The serotonin derivatives such as N-caffeoylserotonin (3) and N-protocatechuoylserotonin (9) were inhibitory to tyrosinase from mouse B16 and human HMV-II melanoma cells, while the corresponding derivatives of tryptamine and 5-methoxytryptamine were almost inactive or less active than the serotonin derivatives. Serotonin 44-53 tyrosinase Mus musculus 112-122 12106075-6 1990 Double immunohistochemical staining using the anti-5-HT1A receptor antibodies and an anti-serotonin (5-HT) antiserum showed that all the 5-HT1A receptor immunoreactive neurons in the dorsal raphe, and the vast majority of them in the median raphe, are serotoninergic neurons. Serotonin 90-99 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 137-143 19236729-3 2009 Neurochemical data revealed that BDNF (100 ng) potentiated the effects of the systemic administration of a serotonin selective reuptake inhibitor (SSRI; paroxetine 4 mg/kg i.p.) Serotonin 107-116 brain derived neurotrophic factor Mus musculus 33-37 33760672-2 2021 While previous in vitro preparations have provided some evidence that 5-HT acts through type 2A receptors (5-HT2A) to facilitate eupnea and gasping, here the hypothesis addressed is that 5-HT2A receptor activation is necessary for eupnea and the proper generation of gasping in vivo. Serotonin 70-74 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 107-113 19541673-7 2009 In contrast, the 5-HT1A receptor exhibited a significantly preferential coupling for Galpha(16/i3) compared with Galpha(16/i2) when serotonin was used as a ligand. Serotonin 132-141 5-hydroxytryptamine receptor 1A Homo sapiens 17-32 33762731-4 2021 Here we report five structures of 5-HT receptor-G-protein complexes: 5-HT1A in the apo state, bound to 5-HT or bound to the antipsychotic drug aripiprazole; 5-HT1D bound to 5-HT; and 5-HT1E in complex with a 5-HT1E- and 5-HT1F-selective agonist, BRL-54443. Serotonin 34-38 5-hydroxytryptamine receptor 1D Homo sapiens 157-163 19280114-5 2009 Interestingly, OCT3 mRNA is however also significantly up-regulated in the hippocampus of serotonin transporter knockout mice where it might serve as an alternative reuptake mechanism for serotonin. Serotonin 90-99 solute carrier family 22 (organic cation transporter), member 3 Mus musculus 15-19 33809253-6 2021 N-(p-Coumaroyl) serotonin and N-feruloyl serotonin, but not serotonin, reduced MMP3, MMP13, and ADAMTS5 expression in IL-1beta-treated chondrocytes. Serotonin 16-25 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) Mus musculus 96-103 33774619-5 2021 We hypothesized that perturbed brain GLUT1/GLUT3 regulated 5-HT-SERT imbalance, which serves as a contributing factor to postnatal neuropsychiatric phenotypes, with OXT/OXTR providing a counterbalance. Serotonin 59-63 oxytocin Mus musculus 165-168 19663258-4 2009 We have reported that serotonin (5-HT), which is important for the effect of antidepressant, increases glial cell line-derived neurotrophic factor (GDNF) via the 5-HT2R-mediated fibroblast growth factor receptor 2 transactivation pathway in glial cells (Tsuchioka et al, 2008). Serotonin 22-31 fibroblast growth factor receptor 2 Homo sapiens 178-213 32890970-9 2020 XBXT could blunt the overexpression of tryptophan hydroxylase 1 (the rate-limiting enzyme of serotonin synthesis) in ileum. Serotonin 93-102 tryptophan hydroxylase 1 Rattus norvegicus 39-63 19437362-4 2009 Platelets from SEPT5 knockout mice show an enhanced serotonin secretion and platelet aggregation in response to subthreshold levels of agonists. Serotonin 52-61 septin 5 Mus musculus 15-20 34971898-6 2022 We determined monoamines in the prefrontal cortex (PFC) using high-performance liquid chromatography and observed a decreased content of serotonin in the PFC of MyD88-KO mice. Serotonin 137-146 myeloid differentiation primary response gene 88 Mus musculus 161-166 19214141-1 2009 OBJECTIVE: Monoamine oxidase-A (MAO-A) is a key mitochondrial enzyme that metabolizes biogenic amine neurotransmitters such as dopamine and serotonin. Serotonin 140-149 monoamine oxidase A Homo sapiens 11-30 34841582-9 2022 Third, early-life selective serotonin reuptake inhibitor exposure alters serotonergic levels, transcription factors expression and brain derived neurotrophic factor levels, resulting in hyperconnectivity within the amygdala and the prefrontal cortex. Serotonin 28-37 brain derived neurotrophic factor Homo sapiens 131-164 19214141-1 2009 OBJECTIVE: Monoamine oxidase-A (MAO-A) is a key mitochondrial enzyme that metabolizes biogenic amine neurotransmitters such as dopamine and serotonin. Serotonin 140-149 monoamine oxidase A Homo sapiens 32-37 34935630-3 2022 In the present study, we have investigated whether beta-catenin activation may also trigger illegitimate expression of GIP and 5-HT receptors. Serotonin 127-131 catenin (cadherin associated protein), beta 1 Mus musculus 51-63 34816281-7 2022 And the expressions of AANAT and ASMT were upregulated by serotonin in luteal cells. Serotonin 58-67 aralkylamine N-acetyltransferase Homo sapiens 23-28 34816281-7 2022 And the expressions of AANAT and ASMT were upregulated by serotonin in luteal cells. Serotonin 58-67 acetylserotonin O-methyltransferase Homo sapiens 33-37 18668366-7 2009 VR1-immunoreactive cells were identified by double-staining immunohistochemistry against gastrin, somatostatin, and serotonin. Serotonin 116-125 vault RNA 1-1 Homo sapiens 0-3 34182358-4 2021 Antidepressant study in vivo of the compound A20 showed that A20 could potently antagonize the p-chloroamphetamine (PCA)-induced depletion of serotonin in hypothalamus and reduce immobility times in the rat forced swimming test (FST). Serotonin 142-151 immunoglobulin kappa variable 1-27 Homo sapiens 45-48 34182358-4 2021 Antidepressant study in vivo of the compound A20 showed that A20 could potently antagonize the p-chloroamphetamine (PCA)-induced depletion of serotonin in hypothalamus and reduce immobility times in the rat forced swimming test (FST). Serotonin 142-151 immunoglobulin kappa variable 1-27 Homo sapiens 61-64 19067144-8 2009 Recently, the role of certain pro-inflammatory cytokines that could enhance the activity of the enzyme, indoleamine 2-3, dioxygenase (IDO) which in turn would increase tryptophan degradation into kynurenine and decrease tryptophan availability of tryptophan in the brain to synthesize serotonin, a neurotransmitter which is necessary for the normal mood state became of interest in pathophysiology of psychiatric disorders. Serotonin 285-294 indoleamine 2,3-dioxygenase 1 Homo sapiens 104-132 34637552-6 2021 VSMC-specific deletion of miR-214 blunts the response of blood vessels to the stimulation of endothelium-dependent and -independent vasorelaxation and phenylephrine and 5-HT induced vasocontraction. Serotonin 169-173 microRNA 214 Mus musculus 26-33 34675083-5 2021 Activation of the endogenous 5-HT receptors on pinealocytes evoked an intracellular Ca2+ rise that was blocked by RS-102221, an antagonist of 5-HT2C receptors. Serotonin 29-33 5-hydroxytryptamine receptor 2C Homo sapiens 142-148 34309872-2 2021 In the absence of Galphaq, SERT mediated uptake of 5-hydroxytryptamine (5HT) was enhanced in midbrain and frontal cortex synaptosomes, but only in female mice. Serotonin 72-75 guanine nucleotide binding protein, alpha q polypeptide Mus musculus 18-25 34309872-10 2021 BIM-46187, which promotes the nucleotide-free form of Galpha proteins, substantially inhibited 5HT uptake, prompting us to hypothesise that Galphaq interacts with SERT similarly as with G protein-coupled receptors and inhibits SERT activity by modulating transport associated conformational changes. Serotonin 95-98 guanine nucleotide binding protein, alpha q polypeptide Mus musculus 140-147 34564712-10 2022 Prior studies suggested that stress-induced dynorphin release within the mNAc activates KOR to potentiate cocaine preference by a reduction in 5-HT tone. Serotonin 143-147 opioid receptor, kappa 1 Mus musculus 88-91 34564712-12 2022 5-HT1B is known to be expressed on 5-HT terminals in NAc, and 5-HT1B transcript was also detected in Pdyn+, Adora2a+ and ChAT+ (markers for direct pathway, indirect pathway, and cholinergic interneurons, respectively). Serotonin 35-39 NLR family, pyrin domain containing 1A Mus musculus 53-56 34564712-14 2022 These findings suggest that Dyn/KOR regulates serotonin activation of 5HT1B receptors within the mNAc and dynamically controls stress response, affect, and drug reward. Serotonin 46-55 opioid receptor, kappa 1 Mus musculus 32-35 7730990-13 1995 injection of CCK increased the concentrations in the dialysate of noradrenaline and serotonin, but not of either adrenaline or dopamine. Serotonin 84-93 cholecystokinin Rattus norvegicus 13-16 7730990-17 1995 Inclusion of morphine in the dialysate also blocked the increase in noradrenaline and serotonin in response to CCK in a naloxone-reversible manner. Serotonin 86-95 cholecystokinin Rattus norvegicus 111-114 7531598-2 1994 Serotonin (5-HT) denervation with 5,7-dihydroxytryptamine (5,7-DHT) caused a significant increase in the density of 5-HT1B receptors in both the ventral (62%) and dorsal (53%) parts of the SCN as early as 3 days after axotomy. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 116-122 7531598-2 1994 Serotonin (5-HT) denervation with 5,7-dihydroxytryptamine (5,7-DHT) caused a significant increase in the density of 5-HT1B receptors in both the ventral (62%) and dorsal (53%) parts of the SCN as early as 3 days after axotomy. Serotonin 11-15 5-hydroxytryptamine receptor 1B Rattus norvegicus 116-122 7821394-6 1994 Striatal indoleamine metabolism, determined by the ratio of 5-hydroxyindoleacetic acid (5HIAA)/serotonin was also elevated by NT-4/5 and BDNF in the caudate-putamen (29, 32%), and the 5HIAA content of the substantia nigra was elevated by both factors (43, 40%). Serotonin 95-104 neurotrophin 4 Rattus norvegicus 126-132 7821394-6 1994 Striatal indoleamine metabolism, determined by the ratio of 5-hydroxyindoleacetic acid (5HIAA)/serotonin was also elevated by NT-4/5 and BDNF in the caudate-putamen (29, 32%), and the 5HIAA content of the substantia nigra was elevated by both factors (43, 40%). Serotonin 95-104 brain-derived neurotrophic factor Rattus norvegicus 137-141 7926490-5 1994 RESULTS: The total volumes of gastrin- and serotonin-immunoreactive cells were significantly increased in the gastric mucosa of germfree rats (P < 0.05), as well as the total volumes of serotonin- and motilin-immunoreactive cells in the ileum (P < 0.05) and serotonin-immunoreactive cells in the colonic mucosa (P < 0.05). Serotonin 189-198 gastrin Rattus norvegicus 30-37 7926490-5 1994 RESULTS: The total volumes of gastrin- and serotonin-immunoreactive cells were significantly increased in the gastric mucosa of germfree rats (P < 0.05), as well as the total volumes of serotonin- and motilin-immunoreactive cells in the ileum (P < 0.05) and serotonin-immunoreactive cells in the colonic mucosa (P < 0.05). Serotonin 189-198 gastrin Rattus norvegicus 30-37 11224238-0 1994 Blockade of the discriminative stimulus effects of d-amphetamine in rhesus monkeys with serotonin 5-HT(1A) agonists. Serotonin 88-97 5-hydroxytryptamine receptor 1A Macaca mulatta 98-105 34475397-4 2021 Inactivation of orexin receptor type 1 in serotonin transporter-expressing cells of mice reduced insulin sensitivity in diet-induced obesity, mainly by decreasing glucose utilization in brown adipose tissue and skeletal muscle. Serotonin 42-51 hypocretin (orexin) receptor 1 Mus musculus 16-38 34239069-0 2021 Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex. Serotonin 73-82 5-hydroxytryptamine receptor 1F Homo sapiens 92-98 19067144-8 2009 Recently, the role of certain pro-inflammatory cytokines that could enhance the activity of the enzyme, indoleamine 2-3, dioxygenase (IDO) which in turn would increase tryptophan degradation into kynurenine and decrease tryptophan availability of tryptophan in the brain to synthesize serotonin, a neurotransmitter which is necessary for the normal mood state became of interest in pathophysiology of psychiatric disorders. Serotonin 285-294 indoleamine 2,3-dioxygenase 1 Homo sapiens 134-137 7870311-12 1994 Many unspecific afferents to the cerebral cortex are potentially regulated by glucocorticoid receptors such as the noradrenaline and 5-hydroxytryptamine afferents, since their nerve cells of origin contain strong glucocorticoid receptor immunoreactivity. Serotonin 133-152 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 78-101 18996226-12 2009 Sonic hedgehog (Shh), PTCH (Shh-R) and Fev1 transcription factor expression coincided with the induction of serotonin specific marker genes during N1-selection. Serotonin 108-117 sonic hedgehog signaling molecule Macaca mulatta 0-14 34448462-8 2021 Melatonin increased the expression of tryptophan hydroxylase 2 (TPH2, serotonin-synthesizing enzyme). Serotonin 70-79 tryptophan hydroxylase 2 Rattus norvegicus 38-62 34448462-8 2021 Melatonin increased the expression of tryptophan hydroxylase 2 (TPH2, serotonin-synthesizing enzyme). Serotonin 70-79 tryptophan hydroxylase 2 Rattus norvegicus 64-68 18996226-12 2009 Sonic hedgehog (Shh), PTCH (Shh-R) and Fev1 transcription factor expression coincided with the induction of serotonin specific marker genes during N1-selection. Serotonin 108-117 sonic hedgehog signaling molecule Macaca mulatta 16-19 34392133-0 2021 Amplification by tramadol of PGD2-induced osteoprotegerin synthesis in osteoblasts: Involvement of mu-opioid receptor and 5-HT transporter. Serotonin 122-126 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 42-57 7915903-1 1994 Several possible mechanisms for 5-hydroxytryptamine (5-HT)-induced tachycardia in rat have been suggested: an activation of 5-HT1C or 5-HT2 receptors, an indirect sympathomimetic effect or a mechanism independent of 5-HT2 receptor stimulation. Serotonin 32-51 5-hydroxytryptamine receptor 2C Rattus norvegicus 124-130 18996226-12 2009 Sonic hedgehog (Shh), PTCH (Shh-R) and Fev1 transcription factor expression coincided with the induction of serotonin specific marker genes during N1-selection. Serotonin 108-117 sonic hedgehog signaling molecule Macaca mulatta 28-31 18826425-1 2009 The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Serotonin 247-256 tryptophan hydroxylase 1 Homo sapiens 196-220 8001641-1 1994 Neonatal destruction of the nigrostriatal dopamine projection by intraventricular 6-hydroxydopamine leads to a serotonin (5-hydroxytryptamine, 5-HT) hyperinnervation of the adult neostriatum accompanied by increased radioligand binding to 5-HT1B, 5-HT1nonAB and 5-HT2 receptors. Serotonin 111-120 5-hydroxytryptamine receptor 1B Rattus norvegicus 239-245 34397817-4 2021 The expression of the Silent Information Regulator 2 Related Enzyme 1 (SIRT1) gene is closely related to the level of serotonin in molecular mechanisms, and may be closely related to the occurrence and development of depressive disorder. Serotonin 118-127 sirtuin 1 Homo sapiens 22-69 34397817-4 2021 The expression of the Silent Information Regulator 2 Related Enzyme 1 (SIRT1) gene is closely related to the level of serotonin in molecular mechanisms, and may be closely related to the occurrence and development of depressive disorder. Serotonin 118-127 sirtuin 1 Homo sapiens 71-76 18826425-1 2009 The Iowa Gambling Task (IGT) was used to examine (i) social decision-making in women with borderline personality disorder (BPD), and (ii) the relationship between impaired decision-making and the tryptophan hydroxylase-1 (TPH-1) gene, involved in serotonin synthesis. Serotonin 247-256 tryptophan hydroxylase 1 Homo sapiens 222-227 34207786-3 2021 In this study, we cloned and characterized the full-length cDNA of three serotonin receptor genes (HTR1B, HTR1E and HTR1F) in chicken pituitaries. Serotonin 73-82 5-hydroxytryptamine receptor 1B Gallus gallus 99-104 34207786-3 2021 In this study, we cloned and characterized the full-length cDNA of three serotonin receptor genes (HTR1B, HTR1E and HTR1F) in chicken pituitaries. Serotonin 73-82 5-hydroxytryptamine receptor 1E Gallus gallus 106-111 8026022-0 1994 Insulin inhibits serotonin-induced Ca2+ influx in vascular smooth muscle. Serotonin 17-26 insulin Canis lupus familiaris 0-7 18823877-3 2009 Here, we investigated whether brain FoxO1 and FoxO3a can be regulated by serotonin and antidepressant treatment and whether their genetic deletion affects behaviors. Serotonin 73-82 forkhead box O1 Mus musculus 36-41 8026022-3 1994 METHODS AND RESULTS: Insulin (40 microU/mL) attenuated the 5-hydroxytryptamine (5-HT, serotonin; 10(-5) mol/L)-induced [Ca2+]i transient (measured by fura 2 fluorescence) in primary confluent canine femoral artery VSMCs in the presence of extracellular Ca2+. Serotonin 59-78 insulin Canis lupus familiaris 21-28 8026022-3 1994 METHODS AND RESULTS: Insulin (40 microU/mL) attenuated the 5-hydroxytryptamine (5-HT, serotonin; 10(-5) mol/L)-induced [Ca2+]i transient (measured by fura 2 fluorescence) in primary confluent canine femoral artery VSMCs in the presence of extracellular Ca2+. Serotonin 86-95 insulin Canis lupus familiaris 21-28 7931509-4 1994 Under current-clamp conditions, 5-hydroxytryptamine (5-HT) or baclofen (BAC) perfusion hyperpolarized CA3 cells. Serotonin 32-51 carbonic anhydrase 3 Rattus norvegicus 102-105 34976083-2 2021 Materials and Methods: In this study, at first, the changes in the expression pattern of 5 dopamine and 2 serotonin (5HTR2B & 5HTR2C) gene receptors were examined in the two groups of healthy and Tuberculosis patients using Real-Time PCR. Serotonin 106-115 5-hydroxytryptamine receptor 2C Homo sapiens 126-132 19124686-1 2009 CONTEXT: Serotonin 1A (5-hydroxytryptamine 1A [5-HT(1A)]) autoreceptors mediate negative feedback inhibition of serotonergic neurons and play a critical role in regulating serotonin signaling involved in shaping the functional response of major forebrain targets, such as the amygdala, supporting complex behavioral processes. Serotonin 9-18 5-hydroxytryptamine receptor 1A Homo sapiens 47-54 35596811-5 2022 In fact, > 90% of 5-HT cells were positive for Rxfp4 labelling. Serotonin 18-22 relaxin family peptide receptor 4 Mus musculus 47-52 35596811-6 2022 A small proportion of cells with Rxfp4-dependent labelling was 5-HT-negative, 11-15% in the distal colon and rectum, and 35% in the proximal colon. Serotonin 63-67 relaxin family peptide receptor 4 Mus musculus 33-38 35596811-12 2022 We conclude that stimuli that excite INSL5-containing colonic L-cells release INSL5 that, through RXFP4, excites 5-HT release from neighbouring endocrine cells, which in turn acts on 5-HT3 receptors of enteric sensory neurons to elicit propulsive reflexes. Serotonin 113-117 insulin-like 5 Mus musculus 37-42 35596811-12 2022 We conclude that stimuli that excite INSL5-containing colonic L-cells release INSL5 that, through RXFP4, excites 5-HT release from neighbouring endocrine cells, which in turn acts on 5-HT3 receptors of enteric sensory neurons to elicit propulsive reflexes. Serotonin 113-117 insulin-like 5 Mus musculus 78-83 35596811-12 2022 We conclude that stimuli that excite INSL5-containing colonic L-cells release INSL5 that, through RXFP4, excites 5-HT release from neighbouring endocrine cells, which in turn acts on 5-HT3 receptors of enteric sensory neurons to elicit propulsive reflexes. Serotonin 113-117 relaxin family peptide receptor 4 Mus musculus 98-103 7931509-4 1994 Under current-clamp conditions, 5-hydroxytryptamine (5-HT) or baclofen (BAC) perfusion hyperpolarized CA3 cells. Serotonin 53-57 carbonic anhydrase 3 Rattus norvegicus 102-105 8080969-3 1994 We now report that lithium also potentiates the response to a serotonin (5-HT) agonist, DOI, that activates 5-HT2/5-HT1C receptors coupled to phosphoinositide hydrolysis. Serotonin 62-71 5-hydroxytryptamine receptor 2C Rattus norvegicus 114-120 19124686-1 2009 CONTEXT: Serotonin 1A (5-hydroxytryptamine 1A [5-HT(1A)]) autoreceptors mediate negative feedback inhibition of serotonergic neurons and play a critical role in regulating serotonin signaling involved in shaping the functional response of major forebrain targets, such as the amygdala, supporting complex behavioral processes. Serotonin 23-42 5-hydroxytryptamine receptor 1A Homo sapiens 47-54 7920184-0 1994 The mouse 5-HT2B receptor: possible involvement in trophic functions of serotonin. Serotonin 72-81 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 10-16 35301029-7 2022 Furthermore, abnormal expression of mRNA levels associated with GABA and serotonin were found in nematodes treated with FB1, such as unc-30, unc-47, unc-49, exp-1, mod-5, cat-1, and tph-1. Serotonin 73-82 Neur_chan_LBD domain-containing protein;Neur_chan_memb domain-containing protein;Uncharacterized protein Caenorhabditis elegans 149-155 19124686-1 2009 CONTEXT: Serotonin 1A (5-hydroxytryptamine 1A [5-HT(1A)]) autoreceptors mediate negative feedback inhibition of serotonergic neurons and play a critical role in regulating serotonin signaling involved in shaping the functional response of major forebrain targets, such as the amygdala, supporting complex behavioral processes. Serotonin 172-181 5-hydroxytryptamine receptor 1A Homo sapiens 47-54 19124686-12 2009 CONCLUSIONS: Our findings further implicate relatively increased serotonin signaling, associated with a genetic variation that mediates increased 5-HT(1A) autoreceptors, in driving amygdala reactivity and trait anxiety. Serotonin 65-74 5-hydroxytryptamine receptor 1A Homo sapiens 146-153 19122313-2 2009 These compounds, which were designed by pharmacophore analysis, bind to both serotonin subtype 1A (5-HT1A) and subtype 3 (5-HT3) receptors. Serotonin 77-86 5-hydroxytryptamine receptor 1A Homo sapiens 99-105 35357273-12 2022 The glutaminergic pathway sensed Glu, subsequently activated GRIK5, DLG4, and NMDA 1 proteins to excite dopaminergic neurons, and finally promoted the production of 5-HT. Serotonin 165-169 discs large MAGUK scaffold protein 4 Mus musculus 68-72 7812819-5 1994 The reduction of MHC-antigens expressiveness, which takes place due to serotonin, is intermediated by the classical 5-HT2 receptor. Serotonin 71-80 major histocompatibility complex, class I, C Homo sapiens 17-20 7908336-7 1994 The activation of swimming by 5HT was associated with a tonic depolarization of cerebral cell 2 (C2) and the dorsal swim interneurons (DSI) which form part of the swim CPG network. Serotonin 30-33 carboxyl ester lipase pseudogene Homo sapiens 89-95 7908336-7 1994 The activation of swimming by 5HT was associated with a tonic depolarization of cerebral cell 2 (C2) and the dorsal swim interneurons (DSI) which form part of the swim CPG network. Serotonin 30-33 carboxyl ester lipase pseudogene Homo sapiens 97-99 19199921-8 2009 U-II produces reactive oxygen species (ROS) via nicotinamide adenine dinucleotide phosphate oxidase activation in human VSMCs, and stimulates VSMC proliferation with synergistic effects when combined with ROS, oxidized LDL, and serotonin. Serotonin 228-237 urotensin 2 Homo sapiens 0-4 8307150-5 1994 The order of affinity of the bovine VMAT2 transporter to substrates is: serotonin > dopamine = norepinephrine > epinephrine. Serotonin 72-81 solute carrier family 18 member A2 Rattus norvegicus 36-41 35337298-2 2022 5-HT biosynthesis is regulated by the rate-limiting enzyme tryptophan hydroxylase-2 (TPH2). Serotonin 0-4 tryptophan hydroxylase 2 Homo sapiens 59-83 35337298-2 2022 5-HT biosynthesis is regulated by the rate-limiting enzyme tryptophan hydroxylase-2 (TPH2). Serotonin 0-4 tryptophan hydroxylase 2 Homo sapiens 85-89 19270731-0 2009 The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network. Serotonin 29-38 vimentin Homo sapiens 83-91 35051377-3 2022 Here, we identify serotonergic (5-HT) neurons as critical mediators that transform gustatory detection by sensory neurons into the activation of insulin-producing cells and enteric neurons in Drosophila. Serotonin 32-36 Insulin-like receptor Drosophila melanogaster 145-152 35051377-4 2022 One class of 5-HT neurons responds to gustatory detection of sugars, excites insulin-producing cells, and limits consumption, suggesting that they anticipate increased nutrient levels and prevent overconsumption. Serotonin 13-17 Insulin-like receptor Drosophila melanogaster 77-84 7931249-8 1994 Increases of tissue and extracellular concentrations of NA and 5HT were highest after Pargyline suggesting that both monoamines may be metabolized by MAO-A and MAO-B. Serotonin 63-66 monoamine oxidase B Rattus norvegicus 160-165 19270731-3 2009 It has been reported that 5HT-stimulation of cells leads to disassembly and spatial reorientation of vimentin filaments. Serotonin 26-29 vimentin Homo sapiens 101-109 35202708-11 2022 Investigation of CCl4-induced ALI mice showed that hepatic injury and apoptosis occur at the site of 5DS activation and are significantly inhibited by the 5-HT2A receptor antagonist and 5-HT synthetic inhibitor in a synergistic manner, as well as mitochondrial damage. Serotonin 186-190 chemokine (C-C motif) ligand 4 Mus musculus 17-21 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 56-59 vimentin Homo sapiens 75-83 19270731-4 2009 METHODOLOGY/PRINCIPAL FINDINGS: We tested the impact of 5HT-stimulation on vimentin-SERT association and found that 5HT-stimulation accelerates the translocation of SERT from the plasma membrane via enhancing the level of association between phosphovimentin and SERT. Serotonin 116-119 vimentin Homo sapiens 75-83 19270731-12 2009 Conversely, following 5HT stimulation, the association between vimentin-SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Serotonin 22-25 vimentin Homo sapiens 63-71 35372578-11 2022 Negative correlation was found between the concentration of VASH-1 and serotonin (r S = -0.19, p < 0.05). Serotonin 71-80 vasohibin 1 Homo sapiens 60-66 35235945-2 2022 Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal. Serotonin 33-37 tryptophan 5-hydroxylase 1 Capra hircus 125-129 8133898-7 1993 The 5-HT1B selective agonist CP 93,129 mimicked the effects of serotonin, but was more potent (EC50 4.1 x 10(-7) mol/l). Serotonin 63-72 5-hydroxytryptamine receptor 1B Rattus norvegicus 4-10 8242348-2 1993 Activities of both MAOA and MAOB were significantly increased in frontal cortex and caudate nucleus, two brain regions shown previously to be the site of functional and morphological alterations of astrocytes and increased concentrations of the acid metabolites of dopamine and serotonin. Serotonin 278-287 monoamine oxidase B Homo sapiens 28-32 19270731-12 2009 Conversely, following 5HT stimulation, the association between vimentin-SERT is enhanced which changes the cellular distribution of SERT on an altered vimentin network. Serotonin 22-25 vimentin Homo sapiens 151-159 35210396-7 2022 We showed that adeno-associated virus (AAV5)-induced overexpression of wild-type human alpha-Syn (h-alpha-Syn) in raphe 5-HT neurons triggers progressive accumulation, phosphorylation, and aggregation of h-alpha-Syn protein in the 5-HT system. Serotonin 120-124 synemin Homo sapiens 106-109 35210396-7 2022 We showed that adeno-associated virus (AAV5)-induced overexpression of wild-type human alpha-Syn (h-alpha-Syn) in raphe 5-HT neurons triggers progressive accumulation, phosphorylation, and aggregation of h-alpha-Syn protein in the 5-HT system. Serotonin 231-235 synemin Homo sapiens 106-109 7694158-2 1993 Stimulation of 5-HT1C receptors with serotonin (5-HT) evoked calcium-dependent outward currents of 109 pA in cells clamped at -50 mV. Serotonin 37-46 5-hydroxytryptamine receptor 2C Rattus norvegicus 15-21 18930727-0 2008 Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions. Serotonin 67-76 tachykinin receptor 1 Rattus norvegicus 0-21 8413046-1 1993 The serum concentration of serotonin (S-5-HT) was measured in 31 patients with primary fibromyalgia, 21 patients with rheumatoid arthritis (RA) (15 of them with secondary fibromyalgia) and 20 healthy volunteers. Serotonin 27-36 ribosomal protein S5 Homo sapiens 38-41 35078807-2 2022 5-HT, synthesized via tryptophan hydroxylase 2 (Tph2), is a widely functioning neuromodulator implicated in fear learning. Serotonin 0-4 tryptophan hydroxylase 2 Rattus norvegicus 22-46 35078807-2 2022 5-HT, synthesized via tryptophan hydroxylase 2 (Tph2), is a widely functioning neuromodulator implicated in fear learning. Serotonin 0-4 tryptophan hydroxylase 2 Rattus norvegicus 48-52 18718470-4 2008 Pharmacological manipulation of serotonin levels regulates synaptophysin and PSA-NCAM expression in the adult mPFC. Serotonin 32-41 neural cell adhesion molecule 1 Rattus norvegicus 81-85 35007690-7 2022 In addition, Western blotting revealed that the increase in 5-HT inhibited ERK2 phosphorylation and upregulated neurogenin1 expression. Serotonin 60-64 neurogenin 1 Rattus norvegicus 112-123 35007690-8 2022 In conclusion, fluoxetine increased the 5-HT level and promoted neuronal differentiation, thereby upregulating neurogenin1 expression and downregulating ERK2 phosphorylation. Serotonin 40-44 neurogenin 1 Rattus norvegicus 111-122 8394988-1 1993 Serotonin [5-hydroxytryptamine (5-HT)] has been implicated in the pathophysiology of migraine, and the clinical efficacy of the 5-HT1B/5-HT1D receptor agonist sumatriptan points to neural and/or vascular 5-HT1D receptors as relevant targets in migraine therapy. Serotonin 0-9 5-hydroxytryptamine receptor 1D Homo sapiens 135-141 8394988-1 1993 Serotonin [5-hydroxytryptamine (5-HT)] has been implicated in the pathophysiology of migraine, and the clinical efficacy of the 5-HT1B/5-HT1D receptor agonist sumatriptan points to neural and/or vascular 5-HT1D receptors as relevant targets in migraine therapy. Serotonin 0-9 5-hydroxytryptamine receptor 1D Homo sapiens 204-210 8232769-10 1993 This embryonic GR may modulate the development of inter alia neuro-endocrine areas such as the paraventricular and arcuate nuclei and arousal-related areas such as the central 5-hydroxytryptamine and noradrenaline neuronal systems. Serotonin 176-195 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 15-17 18536742-7 2008 Serotonin is synthesized, through Tph1, in the endothelial cells of the pulmonary artery and can then act on underlying pulmonary arterial smooth muscle cells and pulmonary arterial fibroblasts in a paracrine fashion causing constriction and remodelling. Serotonin 0-9 tryptophan hydroxylase 1 Homo sapiens 34-38 8513278-8 1993 An interesting linkage appears to exist in the brain between 5-hydroxytryptamine (5-HT) and CCK. Serotonin 61-80 cholecystokinin Rattus norvegicus 92-95 35168555-3 2022 We have previously synthesized serotoninergic receptor ligands (SER) with high affinity and selectivity towards 5-HT2A and 5-HT2C receptors, the main mediators of mitogenic effect of serotonin in breast cancer (BC). Serotonin 183-192 5-hydroxytryptamine receptor 2C Homo sapiens 123-129 35114904-5 2022 Recent studies point out that serotonin (5-hydroxytryptamine, 5-HT) receptors, especially the 2a (5-HT2a) subtype, play an important role in BDNF-related neural plasticity in the VTA. Serotonin 30-39 brain derived neurotrophic factor Homo sapiens 141-145 35114904-5 2022 Recent studies point out that serotonin (5-hydroxytryptamine, 5-HT) receptors, especially the 2a (5-HT2a) subtype, play an important role in BDNF-related neural plasticity in the VTA. Serotonin 41-60 brain derived neurotrophic factor Homo sapiens 141-145 8513278-8 1993 An interesting linkage appears to exist in the brain between 5-hydroxytryptamine (5-HT) and CCK. Serotonin 82-86 cholecystokinin Rattus norvegicus 92-95 18721140-5 2008 The release of the 35 k Da annexin II by matrilysin was significantly enhanced in the presence of serotonin or heparin. Serotonin 98-107 annexin A2 Homo sapiens 27-37 35114904-5 2022 Recent studies point out that serotonin (5-hydroxytryptamine, 5-HT) receptors, especially the 2a (5-HT2a) subtype, play an important role in BDNF-related neural plasticity in the VTA. Serotonin 62-66 brain derived neurotrophic factor Homo sapiens 141-145 18690111-1 2008 Antidepressant drugs produce therapeutic actions and many of their side effects via blockade of the plasma membrane transporters for serotonin (SERT/SLC6A2), norepinephrine (NET/SLC6A1), and dopamine (DAT/SLC6A3). Serotonin 133-142 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus 149-155 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Serotonin 185-194 monoamine oxidase A Homo sapiens 0-19 35046821-12 2021 Plasma Cystatin-C, a cysteine protease, was increased while serotonin and melatonin levels were decreased in Abeta-injected rats. Serotonin 60-69 amyloid beta precursor protein Rattus norvegicus 109-114 1475314-1 1992 The activity of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase (TPH), was studied in the brain of rats bred for 20 generations for predisposition to catalepsy (an excessive freezing). Serotonin 44-53 tryptophan hydroxylase 1 Rattus norvegicus 68-90 1475314-1 1992 The activity of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase (TPH), was studied in the brain of rats bred for 20 generations for predisposition to catalepsy (an excessive freezing). Serotonin 44-53 tryptophan hydroxylase 1 Rattus norvegicus 92-95 1362034-3 1992 The results pose an interesting problem, the possible relation of Fos protein to the biosynthesis of serotonin, awaiting further investigation. Serotonin 101-110 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 66-69 2547897-4 1989 The 5-HT1A [5-hydroxytryptamine (serotonin) type 1A] receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone mimic the serotonin response in reducing the forskolin-stimulated cyclic AMP levels, as do the indole derivatives 5-methoxytryptamine, 5-hydroxtryptophan, and tryptamine. Serotonin 14-31 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 4-10 2547897-4 1989 The 5-HT1A [5-hydroxytryptamine (serotonin) type 1A] receptor agonists 8-hydroxy-2-(di-n-propylamino)tetralin and buspirone mimic the serotonin response in reducing the forskolin-stimulated cyclic AMP levels, as do the indole derivatives 5-methoxytryptamine, 5-hydroxtryptophan, and tryptamine. Serotonin 33-42 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 4-10 1357094-1 1992 In the rat brain, the presynaptic 5-hydroxytryptamine (5-HT) autoreceptors located on 5-HT terminals correspond to the 5-HT1B subtype. Serotonin 34-53 5-hydroxytryptamine receptor 1B Rattus norvegicus 119-125 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Serotonin 185-194 monoamine oxidase A Homo sapiens 21-25 18437281-1 2008 Monoamine oxidase A (MAOA) abnormality has been suggested as a crucial factor in the pathogenesis of mood disorder, because MAOA is associated with the metabolism of monoamines such as serotonin and norepinephrine. Serotonin 185-194 monoamine oxidase A Homo sapiens 124-128 2774768-1 1989 Nerve growth factor (NGF) displays an inhibitory effect on peritoneal dye leakage in mice and on some types of acute inflammation in rats, i.e. acetic acid peritonitis and paw oedema induced by carrageenin, serotonin and dextran. Serotonin 207-216 nerve growth factor Mus musculus 0-19 2774768-1 1989 Nerve growth factor (NGF) displays an inhibitory effect on peritoneal dye leakage in mice and on some types of acute inflammation in rats, i.e. acetic acid peritonitis and paw oedema induced by carrageenin, serotonin and dextran. Serotonin 207-216 nerve growth factor Mus musculus 21-24 18598674-11 2008 ERbeta and PR were detected in CART neurons and CART fibers appeared to innervate TPH-positive serotonin neurons in the dorsal raphe. Serotonin 95-104 CART prepropeptide Macaca mulatta 31-35 2544916-1 1989 The inhibitory potencies of imipramine (IC50-values for IMI) and trazodone (IC50-values for TRA) on platelet [3H]serotonin uptake were measured in depressed patients. Serotonin 113-122 T cell receptor alpha locus Homo sapiens 92-95 2544916-7 1989 The results support the hypothesis that the mechanisms of the regulation of [3H]serotonin uptake sensitivity to IMI and TRA in patients are different. Serotonin 80-89 T cell receptor alpha locus Homo sapiens 120-123 1330642-6 1992 However, the transient cyclic GMP response to serotonin which is due to Ca2+ influx into the neuronal cell line via 5-hydroxytryptamine3 (5-HT3) receptors was not affected by raising the cyclic AMP levels by forskolin pretreatment. Serotonin 46-55 5'-nucleotidase, cytosolic II Homo sapiens 30-33 1355262-3 1992 Also [3H]5HT labels 5HT1C receptors and not 5HT2 receptors. Serotonin 9-12 5-hydroxytryptamine receptor 2C Homo sapiens 20-25 1355262-5 1992 The second messenger studies confirmed the approximately 10-fold higher potency of 5HT in stimulating intracellular responses through 5HT1C receptors (EC50 = 8.3 nM) than in stimulating intracellular responses through 5HT2 receptors (EC50 = 101 nM). Serotonin 83-86 5-hydroxytryptamine receptor 2C Homo sapiens 134-139 1355262-10 1992 The apparent higher affinity of 5HT for the radiolabeled 5HT1C receptors was due to the higher affinity 5HT displayed for the agonist low affinity state of the 5HT1C receptor, compared with the affinity of 5HT for the agonist low affinity state of the 5HT2 receptor. Serotonin 32-35 5-hydroxytryptamine receptor 2C Homo sapiens 57-62 1355262-10 1992 The apparent higher affinity of 5HT for the radiolabeled 5HT1C receptors was due to the higher affinity 5HT displayed for the agonist low affinity state of the 5HT1C receptor, compared with the affinity of 5HT for the agonist low affinity state of the 5HT2 receptor. Serotonin 32-35 5-hydroxytryptamine receptor 2C Homo sapiens 160-165 1355262-10 1992 The apparent higher affinity of 5HT for the radiolabeled 5HT1C receptors was due to the higher affinity 5HT displayed for the agonist low affinity state of the 5HT1C receptor, compared with the affinity of 5HT for the agonist low affinity state of the 5HT2 receptor. Serotonin 57-60 5-hydroxytryptamine receptor 2C Homo sapiens 160-165 1355262-10 1992 The apparent higher affinity of 5HT for the radiolabeled 5HT1C receptors was due to the higher affinity 5HT displayed for the agonist low affinity state of the 5HT1C receptor, compared with the affinity of 5HT for the agonist low affinity state of the 5HT2 receptor. Serotonin 57-60 5-hydroxytryptamine receptor 2C Homo sapiens 160-165 1355262-11 1992 The correspondence between the higher affinity of 5HT for the agonist low affinity state of the 5HT1C receptor, relative to the 5HT2 receptor, and the higher potency of 5HT in stimulating 5HT1C responses indicates that 5HT interacts with the agonist low affinity state of the 5HT1C and 5HT2 receptors in initiating its biological effects. Serotonin 50-53 5-hydroxytryptamine receptor 2C Homo sapiens 96-101 1355262-11 1992 The correspondence between the higher affinity of 5HT for the agonist low affinity state of the 5HT1C receptor, relative to the 5HT2 receptor, and the higher potency of 5HT in stimulating 5HT1C responses indicates that 5HT interacts with the agonist low affinity state of the 5HT1C and 5HT2 receptors in initiating its biological effects. Serotonin 50-53 5-hydroxytryptamine receptor 2C Homo sapiens 188-193 1355262-11 1992 The correspondence between the higher affinity of 5HT for the agonist low affinity state of the 5HT1C receptor, relative to the 5HT2 receptor, and the higher potency of 5HT in stimulating 5HT1C responses indicates that 5HT interacts with the agonist low affinity state of the 5HT1C and 5HT2 receptors in initiating its biological effects. Serotonin 50-53 5-hydroxytryptamine receptor 2C Homo sapiens 188-193 1355262-11 1992 The correspondence between the higher affinity of 5HT for the agonist low affinity state of the 5HT1C receptor, relative to the 5HT2 receptor, and the higher potency of 5HT in stimulating 5HT1C responses indicates that 5HT interacts with the agonist low affinity state of the 5HT1C and 5HT2 receptors in initiating its biological effects. Serotonin 96-99 5-hydroxytryptamine receptor 2C Homo sapiens 188-193 2642918-5 1989 The bronchoconstricting effects of KCl and serotonin, which, like histamine, contract airway smooth muscle by a mechanism predominantly involving membrane potential-dependent Ca2+ transport, were also potentiated by tryptase. Serotonin 43-52 tryptase Canis lupus familiaris 216-224 2811600-0 1989 Characterization of a [3H]-5-hydroxytryptamine binding site in rabbit caudate nucleus that differs from the 5-HT1A, 5-HT1B, 5-HT1C and 5-HT1D subtypes. Serotonin 27-46 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 116-122 1355262-11 1992 The correspondence between the higher affinity of 5HT for the agonist low affinity state of the 5HT1C receptor, relative to the 5HT2 receptor, and the higher potency of 5HT in stimulating 5HT1C responses indicates that 5HT interacts with the agonist low affinity state of the 5HT1C and 5HT2 receptors in initiating its biological effects. Serotonin 96-99 5-hydroxytryptamine receptor 2C Homo sapiens 188-193 18598674-11 2008 ERbeta and PR were detected in CART neurons and CART fibers appeared to innervate TPH-positive serotonin neurons in the dorsal raphe. Serotonin 95-104 CART prepropeptide Macaca mulatta 48-52 1355262-11 1992 The correspondence between the higher affinity of 5HT for the agonist low affinity state of the 5HT1C receptor, relative to the 5HT2 receptor, and the higher potency of 5HT in stimulating 5HT1C responses indicates that 5HT interacts with the agonist low affinity state of the 5HT1C and 5HT2 receptors in initiating its biological effects. Serotonin 96-99 5-hydroxytryptamine receptor 2C Homo sapiens 188-193 1355262-11 1992 The correspondence between the higher affinity of 5HT for the agonist low affinity state of the 5HT1C receptor, relative to the 5HT2 receptor, and the higher potency of 5HT in stimulating 5HT1C responses indicates that 5HT interacts with the agonist low affinity state of the 5HT1C and 5HT2 receptors in initiating its biological effects. Serotonin 96-99 5-hydroxytryptamine receptor 2C Homo sapiens 188-193 1385164-4 1992 In addition to its contractile activity, NPY greatly reduced the maximal response to vasoactive intestinal peptide (VIP), noradrenaline (NA), substance P (SP) and 5-hydroxytryptamine (5-HT), without affecting their pD2 values. Serotonin 163-182 pro-neuropeptide Y Cavia porcellus 41-44 2622528-3 1989 The serotonin perikarya were contacted by a few unlabeled axon terminals containing round synaptic vesicles, and gave rise to dendrites which often ran perpendicularly to the midline. Serotonin 4-13 RAN, member RAS oncogene family Rattus norvegicus 148-151 2622531-1 1989 The binding of [3H]dihydrotetrabenazine, a specific ligand of the monoamine transporter present on serotonin and catecholamine synaptic vesicles, was studied on rat brain sections. Serotonin 99-108 solute carrier family 18 member A2 Rattus norvegicus 66-87 1385164-4 1992 In addition to its contractile activity, NPY greatly reduced the maximal response to vasoactive intestinal peptide (VIP), noradrenaline (NA), substance P (SP) and 5-hydroxytryptamine (5-HT), without affecting their pD2 values. Serotonin 184-188 pro-neuropeptide Y Cavia porcellus 41-44 18187350-1 2008 Mice lacking the serotonin-transporter (5-HTT-/- mice) develop reduced thermal hyperalgesia after nerve injury, concomitant with reduced serotonin (5-HT) levels in nervous tissue. Serotonin 17-26 huntingtin Mus musculus 42-45 2788831-8 1989 In contrast, serotonin-immunostaining was always demonstrable after intrahypothalamic injection of 5-hydroxytryptophan without monoamine oxidase inhibitor in magnocellular neurons located in the ventrolateral posterior hypothalamus and which contain exclusively monoamine oxidase-B and histidine decarboxylase. Serotonin 13-22 histidine decarboxylase Felis catus 286-309 2788831-9 1989 It appears that in these cells and axons, serotonin, possibly formed by histidine decarboxylase, is not rapidly oxidized by monoamine oxidase-B. Serotonin 42-51 histidine decarboxylase Felis catus 72-95 17980409-0 2008 Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. Serotonin 42-51 brain derived neurotrophic factor Mus musculus 27-31 3247254-1 1988 This investigation was undertaken in the unrestrained rat to determine the localized effect of neurotensin (NT) on the profile of release and turnover of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) within the hypothalamus. Serotonin 193-202 neurotensin Rattus norvegicus 95-106 3247254-1 1988 This investigation was undertaken in the unrestrained rat to determine the localized effect of neurotensin (NT) on the profile of release and turnover of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) within the hypothalamus. Serotonin 193-202 neurotensin Rattus norvegicus 108-110 3419153-1 1988 We previously reported that motilin induced both motility and endoluminal release of serotonin (5-HT) in canine jejunum. Serotonin 85-94 motilin Canis lupus familiaris 28-35 1627875-0 1992 Amplification of serotonin-induced arterial contractions with thrombin. Serotonin 17-26 prothrombin Oryctolagus cuniculus 62-70 1627875-1 1992 The purpose of this study was to determine if exposure of arteries to thrombin increases arterial sensitivity to serotonin and could thereby promote vasospasm. Serotonin 113-122 prothrombin Oryctolagus cuniculus 70-78 1627875-8 1992 In contrast, maximal serotonin-induced contractile force was increased after pretreatment with thrombin (107% vs 121% for rings with and without endothelium, respectively; P less than .01). Serotonin 21-30 prothrombin Oryctolagus cuniculus 95-103 1627875-10 1992 However, thrombin pretreatment increased (P less than .01) arterial sensitivity to serotonin 2.6-fold and 4.7-fold for rings with and without endothelium, respectively. Serotonin 83-92 prothrombin Oryctolagus cuniculus 9-17 1627875-11 1992 The results of this study demonstrate that arterial contractions due to serotonin are amplified by thrombin and suggest that vasospasm may be more likely to occur at sites in arteries where the endothelium is absent and both thrombin and serotonin are present. Serotonin 72-81 prothrombin Oryctolagus cuniculus 99-107 1627875-11 1992 The results of this study demonstrate that arterial contractions due to serotonin are amplified by thrombin and suggest that vasospasm may be more likely to occur at sites in arteries where the endothelium is absent and both thrombin and serotonin are present. Serotonin 72-81 prothrombin Oryctolagus cuniculus 225-233 1315531-3 1992 Remarkably, [3H]5-hydroxytryptamine binding studies with transfected HeLa cells show that the human 5-HT1B receptor has a pharmacological profile that is markedly different from that of the corresponding rat receptor. Serotonin 16-35 5-hydroxytryptamine receptor 1B Rattus norvegicus 100-106 18582527-4 2008 Moreover, we found that serotonin (possibly via the 5HT1A receptor) reduces S100B secretion and antagonizes the effect of fluoxetine on S100B secretion. Serotonin 24-33 5-hydroxytryptamine receptor 1A Homo sapiens 52-66 1318161-4 1992 The IC50 value of nifedipine for inhibition of ET-1 mediated contractions was 3.0 +/- 0.8 x 10(-8) M. ET-1 produced a marked prolonged homologous desensitization of its contractile response but did not affect the responses mediated by carbachol, histamine, serotonin, substance P, and PLA2. Serotonin 257-266 endothelin-1 Cavia porcellus 47-51 2839669-1 1988 In the present electrophysiological studies, the effects of the putative 5-hydroxytryptamine (5-HT) receptor antagonist, BMY 7378, on the response of dorsal raphe nucleus 5-HT neurons and of CA3 dorsal hippocampus pyramidal neurons to 5-HT and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) were investigated in chloral hydrate-anesthetized rats. Serotonin 94-98 carbonic anhydrase 3 Rattus norvegicus 191-194 1318161-4 1992 The IC50 value of nifedipine for inhibition of ET-1 mediated contractions was 3.0 +/- 0.8 x 10(-8) M. ET-1 produced a marked prolonged homologous desensitization of its contractile response but did not affect the responses mediated by carbachol, histamine, serotonin, substance P, and PLA2. Serotonin 257-266 endothelin-1 Cavia porcellus 102-106 3399053-6 1988 The major accumulation of monoamine oxidase B-positive neurons was observed in the same regions in which monoamine oxidase B is found to co-localize with serotonin in monkey tissues, including the nucleus raphe dorsalis and the nucleus centralis superior. Serotonin 154-163 monoamine oxidase B Homo sapiens 26-45 18596609-1 2008 The X-linked monoamine oxidase A (MAO A) gene, coding for an enzyme especially involved in the serotonin catabolism, presents a well-characterized functional polymorphism (long and short variants) in the promoter region that alters the transcriptional activity of the gene and hence the function of the corresponding proteins. Serotonin 95-104 monoamine oxidase A Homo sapiens 34-39 3399053-6 1988 The major accumulation of monoamine oxidase B-positive neurons was observed in the same regions in which monoamine oxidase B is found to co-localize with serotonin in monkey tissues, including the nucleus raphe dorsalis and the nucleus centralis superior. Serotonin 154-163 monoamine oxidase B Homo sapiens 105-124 3411442-3 1988 When rabbit platelets were activated by thrombin which induces maximum response, approximately 80% of the platelet serotonin and calcium, but only 50% of platelet magnesium were released. Serotonin 115-124 prothrombin Oryctolagus cuniculus 40-48 1311328-4 1992 The level of PEPCK mRNA in the liver was significantly elevated within 30 min of serotonin administration, whereas 60 min was required in the small intestine and the kidney. Serotonin 81-90 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 13-18 1311328-5 1992 The direct effect of serotonin on PEPCK mRNA was also assessed in hepatocytes maintained in primary culture. Serotonin 21-30 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 34-39 1311328-6 1992 Serotonin (10(-8) M to 10(-4) M) caused a dose-dependent increase in the level of PEPCK mRNA and a transient increase in cAMP concentration. Serotonin 0-9 phosphoenolpyruvate carboxykinase 1 Rattus norvegicus 82-87 1323803-0 1992 Coordinative mineralocorticoid and glucocorticoid receptor-mediated control of responses to serotonin in rat hippocampus. Serotonin 92-101 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 35-58 18254726-6 2008 Since melatonin is known to inhibit QR2 activity, but its binding site and mode of inhibition are not known, we determined the mechanism of inhibition of QR2 by melatonin and a series of melatonin and 5-hydroxytryptamine (serotonin) analogues, and we determined the X-ray structures of melatonin and 2-iodomelatonin in complex with QR2 to between 1.5 and 1.8 A (1 A=0.1 nm) resolution. Serotonin 222-231 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 154-157 1371218-0 1992 Loss of extrasynaptic channel modulation by protein kinase C underlies the selection of serotonin responses in an identified leech neuron. Serotonin 88-97 protein kinase C, gamma Rattus norvegicus 44-60 2966313-0 1988 Serotonin-1A receptor activation in hippocampal CA1 neurons by 8-hydroxy-2-(di-n-propylamino)tetralin, 5-methoxytryptamine and 5-hydroxytryptamine. Serotonin 127-146 carbonic anhydrase 1 Homo sapiens 48-51 2966313-1 1988 Serotonin (5-HT) usually induced a slow hyperpolarization lasting several minutes on first drop-application onto CA1 neurons. Serotonin 0-9 carbonic anhydrase 1 Homo sapiens 113-116 2966310-1 1988 In human caudate and cortex membranes, [3H]serotonin ([3H]5-HT) labels 5-HT1A and 5-HT1C recognition sites which show nanomolar affinity for 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)-tetralin) and mesulergine respectively, whereas no 5-HT1B binding could be identified. Serotonin 43-52 5-hydroxytryptamine receptor 2C Homo sapiens 82-88 1371218-1 1992 Pressure-sensitive (P) neurons contacted by serotonergic Retzius (R) neurons of the leech in culture selectively reduce a protein kinase C (PKC)-dependent cation response to serotonin and are innervated by the inhibitory, Cl(-)-dependent synapse seen in vivo. Serotonin 174-183 protein kinase C, gamma Rattus norvegicus 122-138 1371218-1 1992 Pressure-sensitive (P) neurons contacted by serotonergic Retzius (R) neurons of the leech in culture selectively reduce a protein kinase C (PKC)-dependent cation response to serotonin and are innervated by the inhibitory, Cl(-)-dependent synapse seen in vivo. Serotonin 174-183 protein kinase C, gamma Rattus norvegicus 140-143 3341767-0 1988 A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. Serotonin 86-95 prothrombin Oryctolagus cuniculus 69-77 18254726-6 2008 Since melatonin is known to inhibit QR2 activity, but its binding site and mode of inhibition are not known, we determined the mechanism of inhibition of QR2 by melatonin and a series of melatonin and 5-hydroxytryptamine (serotonin) analogues, and we determined the X-ray structures of melatonin and 2-iodomelatonin in complex with QR2 to between 1.5 and 1.8 A (1 A=0.1 nm) resolution. Serotonin 222-231 N-ribosyldihydronicotinamide:quinone reductase 2 Homo sapiens 154-157 3341767-1 1988 Zinc ions at micromolar levels exhibited a significant inhibitory activity toward platelet activating factor (AGEPC)- and thrombin-induced serotonin release from washed rabbit platelets. Serotonin 139-148 prothrombin Oryctolagus cuniculus 122-130 3341767-9 1988 It is apparent that zinc ions influence a site(s) on the rabbit platelet of considerable importance to the activation (or signaling) process by AGEPC and thrombin in these cells, as expressed by serotonin release. Serotonin 195-204 prothrombin Oryctolagus cuniculus 154-162 17971260-0 2008 Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635. Serotonin 16-25 5-hydroxytryptamine receptor 1A Homo sapiens 26-41 3337452-5 1988 In the cystic fibrosis (n = 55, 3 days to 29 yr of age) and prolonged ventilation (n = 24, 4 months to 18 yr of age) groups, there was a significant increase (p less than 0.035) in bombesin, calcitonin, and serotonin immunoreactive bronchioles/cm2 from 1 to 11 yr of age. Serotonin 207-216 gastrin releasing peptide Homo sapiens 181-189 12106322-0 1992 On the Distribution of GAP-43 and its Relation to Serotonin in Adult Monkey and Cat Spinal Cord and Lower Brainstem. Serotonin 50-59 neuromodulin Felis catus 23-29 20641420-2 2004 MAO-A preferentially oxidizes serotonin and noradrenaline, whereas MAO-B preferentially oxidizes phenethylamine. Serotonin 30-39 monoamine oxidase A Homo sapiens 0-5 1291694-7 1992 After application of superoxide dismutase and catalase, the normal vasoconstrictor response to serotonin was restored. Serotonin 95-104 catalase Felis catus 46-54 3282654-2 1988 In analogy, we have studied whether it is possible to enhance the number of intratumoral macrophages by injecting serotonin into a s.c. SL2 lymphosarcoma. Serotonin 114-123 matrix metallopeptidase 10 Homo sapiens 136-139 18389517-2 2008 With the purpose of designing new chemical entities with enhanced antagonist potencies against 5-HT1A and 5-HT1B, a QSAR study carried out on thienopyrimidinone derivatives as antagonists of serotonin autoreceptors is presented. Serotonin 191-200 5-hydroxytryptamine receptor 1A Homo sapiens 95-112 2456276-1 1988 The platelet-activating factor (PAF) has been shown to stimulate the release of prostaglandins, leukotrienes and 5HT from a number of cell types. Serotonin 113-116 PCNA clamp associated factor Rattus norvegicus 4-30 1507551-0 1992 Potentiation by endothelin-1 of 5-hydroxytryptamine-induced contraction in coronary artery of the pig. Serotonin 32-51 endothelin-1 Sus scrofa 16-28 17949690-7 2008 RESULTS: Mice experiencing low maternal care showed deficient gamma-aminobutyric acid-A receptor binding in the amygdala and 5-HTT heterozygous null mice showed decreased serotonin turnover in hippocampus and striatum. Serotonin 171-180 huntingtin Mus musculus 127-130 1545496-4 1992 These results indicate that the actions of PGD2 depend upon serotonin and norepinephrine systems. Serotonin 60-69 prostaglandin D2 synthase (brain) Mus musculus 43-47 1726120-0 1991 Enkephalin, substance P, and serotonin axonal input to c-fos-like immunoreactive neurons of the rat spinal cord. Serotonin 29-38 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 55-60 3429259-6 1987 Serotonin immunoreactivity in the absence of an argentaffin reaction was evident in some G (gastrin) cells, and in some D1 and possibly also some D (somatostatin) cells; but not all the endocrine cells of the non-enterochromaffin type displayed serotonin immunoreactivity. Serotonin 0-9 gastrin Rattus norvegicus 92-99 18332855-0 2008 Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT(1A) receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 87-94 2444183-1 1987 In rats the effect of inhibition of the brain cholinesterase activity on the pressor and heart rate responses to 5-hydroxytryptamine (5-HT), administered into the lateral cerebral ventricle (l.c.v.) Serotonin 113-132 butyrylcholinesterase Rattus norvegicus 46-60 3498585-11 1987 It markedly inhibits C3a-induced 3H-serotonin release from platelets in vitro and similarly inhibits the C3a-induced extravasation of Evans blue into the skin in vivo. Serotonin 36-45 complement C3 Homo sapiens 21-24 2442053-6 1987 Synaptophysin was identified throughout, the whole range of these NE neoplasms, i.e., from benign to low-grade to aggressive and rapidly metastasizing carcinomas; its presence was unaffected by the highly variable expression of serotonin and/or neuropeptides in these neoplasms, and was unrelated to the presence or absence of associated endocrine syndromes. Serotonin 228-237 synaptophysin Homo sapiens 0-13 1726120-4 1991 The analysis of vibratome and semithin plastic-embedded tissue sections demonstrated that the majority of c-fos-like immunoreactive neurons received input from enkephalin-, substance P- or serotonin-immunoreactive axonal varicosities. Serotonin 189-198 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 106-111 1895098-0 1991 Acetylation of serotonin in the rabbit pineal gland: an N-acetyltransferase with properties distinct from NAT1 and NAT2 is responsible. Serotonin 15-24 arylamine N-acetyltransferase 2 Oryctolagus cuniculus 115-119 1895098-4 1991 Similarity of the liver enzymes and the pineal gland arylalkylamine N-acetyltransferase (AA-NAT) has been suggested, because pineal gland homogenates were shown to metabolize arylamine substrates as p-phenetidine, aniline, or phenylethylamine, and liver homogenates or partially purified liver enzyme preparations catalyzed the N-acetylation of serotonin. Serotonin 345-354 serotonin N-acetyltransferase Oryctolagus cuniculus 53-87 1895098-4 1991 Similarity of the liver enzymes and the pineal gland arylalkylamine N-acetyltransferase (AA-NAT) has been suggested, because pineal gland homogenates were shown to metabolize arylamine substrates as p-phenetidine, aniline, or phenylethylamine, and liver homogenates or partially purified liver enzyme preparations catalyzed the N-acetylation of serotonin. Serotonin 345-354 serotonin N-acetyltransferase Oryctolagus cuniculus 89-95 3566833-0 1986 Behavioral effects and general pharmacology of 4-(5-chloro-benzofuranyl-2)-1-methylpiperidine HC1, an antidepressant inhibiting both monoamine oxidase A and 5-hydroxytryptamine uptake. Serotonin 157-176 Hypercalciuria QTL 1 Rattus norvegicus 94-97 18366201-16 2008 In most cases, the experimental thresholds are well reproduced by calculated transition states separating the conformational wells; however, tunneling effects may artificially reduce the thresholds observed for isomerization of SERO(A,Gpy(out)) and SERO(B,Gpy(up)) into SERO(C,Gph(out)). Serotonin 228-232 gephyrin Homo sapiens 277-280 2949988-1 1986 The effects of intracerebroventricular injection of atrial natriuretic polypeptide (ANP) and angiotensin II (AII) on the concentration of dopamine, noradrenaline, serotonin and their primary metabolites in the rat brain were studied using high performance liquid chromatography with electrochemical detection. Serotonin 163-172 natriuretic peptide A Rattus norvegicus 84-87 1656340-0 1991 Inhibitory effects of KN-62, a specific inhibitor of Ca/calmodulin-dependent protein kinase II, on serotonin-evoked C1-current and 36-C1-efflux in Xenopus oocytes. Serotonin 99-108 calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog Xenopus laevis 56-94 1922690-4 1991 Modes of inhibition of MAO-A and MAO-B by ifenprodil were competitive towards oxidation of their respective substrates, 5-hydroxytryptamine and benzylamine, with Ki values of 75 microM for inhibition of MAO-A and 110 microM for inhibition of MAO-B. Serotonin 120-139 monoamine oxidase B Rattus norvegicus 33-38 18366201-16 2008 In most cases, the experimental thresholds are well reproduced by calculated transition states separating the conformational wells; however, tunneling effects may artificially reduce the thresholds observed for isomerization of SERO(A,Gpy(out)) and SERO(B,Gpy(up)) into SERO(C,Gph(out)). Serotonin 249-253 gephyrin Homo sapiens 277-280 18366201-16 2008 In most cases, the experimental thresholds are well reproduced by calculated transition states separating the conformational wells; however, tunneling effects may artificially reduce the thresholds observed for isomerization of SERO(A,Gpy(out)) and SERO(B,Gpy(up)) into SERO(C,Gph(out)). Serotonin 249-253 gephyrin Homo sapiens 277-280 18198200-0 2008 Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments. Serotonin 26-45 heart and neural crest derivatives expressed 2 Mus musculus 103-106 1718052-6 1991 VM16d also inhibited 14C-serotonin secretion induced by low dose thrombin and binding of 125I-thrombin but not ristocetin-dependent binding of 125I-vWF to platelets. Serotonin 25-34 coagulation factor II, thrombin Bos taurus 65-73 3024235-2 1986 PAF caused serotonin release from platelets and a characteristic shape change and adhesion of neutrophils. Serotonin 11-20 PCNA clamp associated factor Rattus norvegicus 0-3 17680805-0 2008 Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice. Serotonin 40-49 general transcription factor II I repeat domain-containing 1 Mus musculus 64-72 3738764-0 1986 Motilin"s induction of phasic contractility in canine jejunum is mediated by the luminal release of serotonin. Serotonin 100-109 motilin Canis lupus familiaris 0-7 3738764-8 1986 These findings suggest that motilin initiates phasic contractility in canine jejunum through the cholinergically mediated release of mucosal serotonin. Serotonin 141-150 motilin Canis lupus familiaris 28-35 1654599-3 1991 TFC-612 also inhibited thrombin induced (14C) serotonin release in rabbit platelets. Serotonin 46-55 prothrombin Oryctolagus cuniculus 23-31 2020669-2 1991 Preincubation of rat serosal mast cells with synthetic 1-34 bovine parathyroid hormone (1-34bPTH) significantly enhanced antigen-induced 5-hydroxytryptamine (5-HT) release. Serotonin 137-156 parathyroid hormone Bos taurus 67-86 18195357-7 2008 In mice, we find that serotonin induces a head twitch response by a beta-arrestin-2-dependent mechanism. Serotonin 22-31 arrestin, beta 2 Mus musculus 68-83 1852219-0 1991 Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex. Serotonin 35-44 5-hydroxytryptamine receptor 1B Rattus norvegicus 67-73 1852219-13 1991 The results confirm the view that the serotonin axons of rat brain possess 5-HT1B autoreceptors. Serotonin 38-47 5-hydroxytryptamine receptor 1B Rattus norvegicus 75-81 1852219-16 1991 The serotonin axons of rat brain cortex may possess 5-HT1D in addition to 5-HT1B autoreceptors. Serotonin 4-13 5-hydroxytryptamine receptor 1B Rattus norvegicus 74-80 3016436-3 1986 In blowfly salivary gland membranes, 5-hydroxytryptamine stimulates a guanine-nucleotide dependent breakdown of both endogenous and exogenous phosphoinositide substrate through activation of phospholipase C. These data suggest that a GTP-binding protein modulates phospholipase C activity. Serotonin 37-56 RAS like proto-oncogene B Rattus norvegicus 234-253 3810119-5 1986 A large number of cells containing serotonin (5-HT) in the B2 and B6 areas were labeled by FB, while only a few FB-labeled 5-HT cells in B8, B9 were seen. Serotonin 35-44 UDP glucuronosyltransferase 1 family, polypeptide A2 Rattus norvegicus 59-68 18195357-10 2008 Our study suggests that the 5-HT2AR-beta-arrestin interaction may be particularly important in receptor function in response to endogenous serotonin levels, which could have major implications in drug development for treating neuropsychiatric disorders such as depression and schizophrenia. Serotonin 139-148 S-antigen, retina and pineal gland (arrestin) Mus musculus 41-49 3702610-3 1986 We describe here a method based on the prior acetylation of lyso PAF extracted from plasma to PAF before bioassay using 14C-serotonin labelled platelets. Serotonin 124-133 PCNA clamp associated factor Rattus norvegicus 65-68 2054606-3 1991 In both organs, melatonin is synthesized from serotonin by the sequential action of the enzymes, N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), and can be stimulated by increases in cyclic AMP through a mechanism requiring protein synthesis. Serotonin 46-55 bromodomain containing 2 Homo sapiens 97-116 2054606-3 1991 In both organs, melatonin is synthesized from serotonin by the sequential action of the enzymes, N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), and can be stimulated by increases in cyclic AMP through a mechanism requiring protein synthesis. Serotonin 46-55 bromodomain containing 2 Homo sapiens 118-121 2054606-3 1991 In both organs, melatonin is synthesized from serotonin by the sequential action of the enzymes, N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), and can be stimulated by increases in cyclic AMP through a mechanism requiring protein synthesis. Serotonin 46-55 acetylserotonin O-methyltransferase Homo sapiens 127-160 18799894-1 2008 Alpha-synuclein (alpha-Syn) is a neuronal protein involved in the regulation of brain serotonin and dopamine levels. Serotonin 86-95 synuclein alpha Homo sapiens 0-15 2054606-3 1991 In both organs, melatonin is synthesized from serotonin by the sequential action of the enzymes, N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT), and can be stimulated by increases in cyclic AMP through a mechanism requiring protein synthesis. Serotonin 46-55 acetylserotonin O-methyltransferase Homo sapiens 162-167 3487052-6 1986 It is proposed that the conversion of MPTP to MPP+ occurs via MAO-B within serotonin and histamine neurons which may innervate the substantia nigra where the toxin MPP+ could be released and then taken up into the dopamine neurons. Serotonin 75-84 monoamine oxidase B Rattus norvegicus 62-67 1665042-1 1991 Effect of serotonin and DBcAMP on the expression of GFAP and its encoding message. Serotonin 10-19 glial fibrillary acidic protein Homo sapiens 52-56 18799894-1 2008 Alpha-synuclein (alpha-Syn) is a neuronal protein involved in the regulation of brain serotonin and dopamine levels. Serotonin 86-95 synuclein alpha Homo sapiens 17-26 18052766-7 2007 However, it is likely that cholinesterase inhibitors, antipsychotics and anti-5-hydroxytryptamine(3) agents and drugs acting on sleep regulation will have different and perhaps opposite effects on different types of hallucinations, whether they are accompanied by disturbed insight, sleep disorders or other psychotic features. Serotonin 78-97 butyrylcholinesterase Homo sapiens 27-41 1988650-0 1991 Protein kinase C translocation in rat stomach fundus: effects of serotonin, carbamylcholine and phorbol dibutyrate. Serotonin 65-74 protein kinase C, gamma Rattus norvegicus 0-16 1988650-6 1991 Focusing on PKC, serotonin"s ability to translocate PKC from cytosol to membrane in rat fundus was examined. Serotonin 17-26 protein kinase C, gamma Rattus norvegicus 52-55 1988650-9 1991 These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus. Serotonin 327-336 protein kinase C, gamma Rattus norvegicus 52-55 2421460-2 1986 The present study was designed primarily to quantify the inhibition produced by antithrombin III of the phasic responses elicited by cumulative doses of KCl, serotonin (5-HT), uridine triphosphate (UTP), and thrombin in isolated canine basilar arteries, and to ascertain whether other proteins might act similarly. Serotonin 158-167 serpin family C member 1 Canis lupus familiaris 80-96 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 8-17 monoamine oxidase B Homo sapiens 268-273 3008207-7 1986 As both serotonin and norepinephrine are preferentially metabolized by MAO-A rather than MAO-B, an increased availability of serotonin (the precursor of melatonin) or enhanced noradrenergic function might mediate the melatonin changes observed to follow MAO-A but not MAO-B inhibition. Serotonin 125-134 monoamine oxidase B Homo sapiens 268-273 17874074-9 2007 A suggested clinical implication is that the inter-individual variability in 5-HT1A-receptor and 5-HTT densities, as well as the ratio of these, is of particular interest in relation to individual responses to selective serotonin reuptake inhibitor treatment. Serotonin 220-229 5-hydroxytryptamine receptor 1A Homo sapiens 77-92 3720689-9 1986 These results demonstrate that both 5HT and BOM content in endocrine cells of explants from human fetal airways can be well maintained in organ culture for at least 5 days and that they are responsive to pharmacologic inhibition of 5HT synthesis. Serotonin 232-235 gastrin releasing peptide Homo sapiens 44-47 1684835-10 1991 The concentrations of somatostatin were highest in CA1; those of serotonin were highest in CA3. Serotonin 65-74 carbonic anhydrase 3 Rattus norvegicus 91-94 18265561-3 2007 Study of degeneration, mitotic activity, and differentiation (by using immunohistochemical detection of nerve cell nuclear protein--NeuN) of transplanted cells has allowed establishing that serotonin promotes survival and differentiation of transplant neuroepithelial cells as well as participates in regulation of their proliferation. Serotonin 190-199 RNA binding fox-1 homolog 3 Rattus norvegicus 132-136 2932194-3 1985 Synthetic ANF was found to cause relaxation of the renal vessels when these were sub-maximally activated with K+, noradrenaline or 5-hydroxytryptamine, but had no effect on the responses of the other vessels to these agonists. Serotonin 131-150 natriuretic peptide A Rattus norvegicus 10-13 1701964-2 1990 Pancreatic generation of PAF, as measured by bioassay (ie, platelet [3H]serotonin secretion), was determined at various times after induction of inflammation. Serotonin 72-81 PCNA clamp associated factor Rattus norvegicus 25-28 17620344-6 2007 The coexpression of both UGT1A1 and UGT1A4 increased the V(max) values of UGT1A6-catalyzed serotonin and diclofenac O-glucuronide formation. Serotonin 91-100 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 36-42 17640952-0 2007 The time-course for up- and down-regulation of the cortical 5-hydroxytryptamine (5-HT)2A receptor density predicts 5-HT2A receptor-mediated behavior in the rabbit. Serotonin 60-79 5-hydroxytryptamine receptor 2A Oryctolagus cuniculus 115-130 2078982-0 1990 EOG and ERG modifications induced in the chicken eye after blockade of catecholamine and 5-hydroxytryptamine biosynthesis. Serotonin 89-108 ETS transcription factor ERG Gallus gallus 8-11 2264020-4 1990 In contrast, two other antibodies, named P14 and P34, themselves caused aggregation of rat platelets in platelet-rich plasma (PRP) and the secretion of 14C-serotonin from 14C-serotonin-labeled PRP. Serotonin 156-165 proline rich protein 2-like 1 Rattus norvegicus 193-196 2264020-4 1990 In contrast, two other antibodies, named P14 and P34, themselves caused aggregation of rat platelets in platelet-rich plasma (PRP) and the secretion of 14C-serotonin from 14C-serotonin-labeled PRP. Serotonin 175-184 proline rich protein 2-like 1 Rattus norvegicus 193-196 2581166-1 1985 Intracarotid infusions of neurotensin (NT) into the isolated, perfused head of rats trigger concentration-dependent histamine and 5-hydroxytryptamine (5-HT) release from the perfused organ. Serotonin 130-149 neurotensin Rattus norvegicus 26-37 2581275-0 1985 The effects produced by prostaglandin D2 on serotonin turnover and release and tryptophan uptake. Serotonin 44-53 prostaglandin D2 synthase (brain) Mus musculus 24-40 2581275-2 1985 The actions of PGD2 on neuronal turnover and release of serotonin and uptake of tryptophan were examined in mice. Serotonin 56-65 prostaglandin D2 synthase (brain) Mus musculus 15-19 3967936-2 1985 The responsiveness of the animals" peritoneal mast cells to in vitro challenge with beta-LG was determined by measurement of release of radiolabelled 5-hydroxytryptamine. Serotonin 150-169 beta-lactoglobulin Bos taurus 84-91 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Serotonin 128-137 solute carrier family 23 member 1 Homo sapiens 73-80 2410561-4 1985 These results confirm the view that CSF 5-HIAA may serve as a good index of brain serotonin turnover. Serotonin 82-91 colony stimulating factor 2 Rattus norvegicus 36-39 2374139-0 1990 3-(1,2,5,6-Tetrahydropyrid-4-yl)pyrrolo[3,2-b]pyrid-5-one: a potent and selective serotonin (5-HT1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. Serotonin 82-91 5-hydroxytryptamine receptor 1B Rattus norvegicus 93-99 2170629-8 1990 Acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) activated neuronal PKC by 3- to 8-fold. Serotonin 24-43 protein kinase C, gamma Rattus norvegicus 70-73 17592150-0 2007 Enteroendocrine precursors differentiate independently of Wnt and form serotonin expressing adenomas in response to active beta-catenin. Serotonin 71-80 catenin beta 1 Homo sapiens 123-135 2170629-8 1990 Acetylcholine (ACh) and 5-hydroxytryptamine (5-HT) activated neuronal PKC by 3- to 8-fold. Serotonin 45-49 protein kinase C, gamma Rattus norvegicus 70-73 2170629-12 1990 Pre-treatment of sympathetic neurons or adrenal medulla with a PKC inhibitor H7 (1-(5-isoquinolinyl-sulphonyl)-2-methyl-piperazine) almost completely blocked activation of the enzyme induced by PDB, ACh or 5-HT. Serotonin 206-210 protein kinase C, gamma Rattus norvegicus 63-66 2161757-6 1990 The serotonin-induced rise of cyclic-GMP level depends on the presence of extracellular Ca2+ with half-maximal stimulation at 0.3 mM Ca2+. Serotonin 4-13 5'-nucleotidase, cytosolic II Homo sapiens 37-40 6505225-7 1984 These results suggest that PAF elicits edema at vascular sites of the rat hindpaw which are partially dependent on extracellular Ca2+ movement, are not due to alpha-1 or alpha-2-adrenoreceptor stimulation, histamine, serotonin, or prostaglandin activity, and demonstrates variable sensitivities to agents blocking Ca2+ entry. Serotonin 217-226 PCNA clamp associated factor Rattus norvegicus 27-30 6425408-2 1984 The granule markers, endogenous beta-hexosaminidase and exogenously added [3H]serotonin, were released from 2.5 X 10(5) RMC in 50 microliters in parallel and in dose-response fashion, reaching a maximum net percent release of approximately 50% with 0.5 to 1.0 units chymase (15 U/mg)/ml. Serotonin 78-87 chymase 1 Rattus norvegicus 266-273 6422173-0 1984 Participation of mast cell 5-hydroxytryptamine in the vasoconstrictor effect of neurotensin in the rat perfused hindquarter. Serotonin 27-46 neurotensin Rattus norvegicus 80-91 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Serotonin 127-136 monoamine oxidase A Homo sapiens 38-57 17561096-1 2007 The degradation of biogenic amines by monoamine oxidase A (MAO-A) generates reactive oxygen species (ROS) which participate in serotonin and tyramine signaling. Serotonin 127-136 monoamine oxidase A Homo sapiens 59-64 2323038-0 1990 Neuron-glia interactions: effect of serotonin on the astroglial expression of GFAP and of its encoding message. Serotonin 36-45 glial fibrillary acidic protein Rattus norvegicus 78-82 2323038-1 1990 The trophic effect of serotonin on the glial fibrillary acidic protein (GFAP) expression was investigated in rat brainstem astrocytes in primary culture. Serotonin 22-31 glial fibrillary acidic protein Rattus norvegicus 39-70 17156118-5 2007 Age-related loss of serotonin axons in the hippocampus was potentiated in BDNF(+/-) mice compared with wildtype mice at this late age, particularly in the CA1 subregion. Serotonin 20-29 brain derived neurotrophic factor Mus musculus 74-78 2323038-1 1990 The trophic effect of serotonin on the glial fibrillary acidic protein (GFAP) expression was investigated in rat brainstem astrocytes in primary culture. Serotonin 22-31 glial fibrillary acidic protein Rattus norvegicus 72-76 2323038-4 1990 Serotonin may act as an inhibitor of GFAP expression either on the transcription or on the stability of the GFAP-mRNA. Serotonin 0-9 glial fibrillary acidic protein Rattus norvegicus 37-41 2323038-4 1990 Serotonin may act as an inhibitor of GFAP expression either on the transcription or on the stability of the GFAP-mRNA. Serotonin 0-9 glial fibrillary acidic protein Rattus norvegicus 108-112 6205560-0 1984 Effect of beta 2-adrenoceptor agonists on serotonin biochemistry and function. Serotonin 42-51 adrenoceptor beta 2 Homo sapiens 10-29 6096645-2 1984 After the treatment cycles with Triton X-100 about 23 and 36% of the original mitochondrial MAO-A and MAO-B activity, respectively, towards 0.1 mM serotonin and benzylamine remained in the residue. Serotonin 147-156 monoamine oxidase B Rattus norvegicus 102-107 6227192-0 1983 Mechanism of serotonin effects on prolactin and growth hormone secretion in domestic fowl. Serotonin 13-22 prolactin Gallus gallus 34-43 17156118-6 2007 By contrast, aging BDNF(+/-) mice showed increased serotonin innervation of the basomedial nucleus of the amygdala. Serotonin 51-60 brain derived neurotrophic factor Mus musculus 19-23 6227192-8 1983 These results suggest that serotonin stimulates prolactin secretion in chickens by increasing pituitary responsiveness to hypothalamic releasing factors and by increasing the prolactin releasing activity of the hypothalamus. Serotonin 27-36 prolactin Gallus gallus 48-57 17156118-8 2007 In vivo zero net flux microdialysis in awake mice showed a significant decrease in extracellular serotonin levels in the hippocampus in BDNF(+/-) mice at 20 months of age. Serotonin 97-106 brain derived neurotrophic factor Mus musculus 136-140 17452494-5 2007 Application of serotonin inhibited the excitability of stellate and pyramidal neurons in the superficial layers of the EC by activating the TWIK-1 type of the two-pore domain K(+) channels. Serotonin 15-24 potassium two pore domain channel subfamily K member 1 Homo sapiens 140-146 6648902-2 1983 When bovine unwashed platelets were preincubated with 5-hydroxytryptamine (5HT) (or ADP), they became non responding to that agonist (refractory) but they responded quite normally to collagen, thrombin and ADP (or 5HT). Serotonin 54-73 coagulation factor II, thrombin Bos taurus 193-201 6648902-2 1983 When bovine unwashed platelets were preincubated with 5-hydroxytryptamine (5HT) (or ADP), they became non responding to that agonist (refractory) but they responded quite normally to collagen, thrombin and ADP (or 5HT). Serotonin 75-78 coagulation factor II, thrombin Bos taurus 193-201 2351370-4 1990 Administered alone, sulfated CCK octapeptide (CCK 8 S) (5 micrograms/kg ip) and diazepam (5 mg/kg ip) were found to decrease DOPAC levels in the cortex and to induce 5-hydroxy-tryptamine accumulation in the hippocampus. Serotonin 166-186 cholecystokinin Rattus norvegicus 29-32 2351370-4 1990 Administered alone, sulfated CCK octapeptide (CCK 8 S) (5 micrograms/kg ip) and diazepam (5 mg/kg ip) were found to decrease DOPAC levels in the cortex and to induce 5-hydroxy-tryptamine accumulation in the hippocampus. Serotonin 166-186 cholecystokinin Rattus norvegicus 46-49 33794383-6 2021 NOX4 and TRPM2 were upregulated in pulmonary arteries of CHPH rats, which was associated with elevated levels of 5-HT and ROS, and enhanced proliferation and migration in PASMCs. Serotonin 113-117 NADPH oxidase 4 Rattus norvegicus 0-4 33794383-8 2021 5-HT and CH-induced ROS production were reversed by catalase, the NOX1/NOX4 inhibitor GKT137831, and Nox4 siRNA. Serotonin 0-4 NADPH oxidase 1 Rattus norvegicus 66-70 33794383-8 2021 5-HT and CH-induced ROS production were reversed by catalase, the NOX1/NOX4 inhibitor GKT137831, and Nox4 siRNA. Serotonin 0-4 NADPH oxidase 4 Rattus norvegicus 71-75 33794383-8 2021 5-HT and CH-induced ROS production were reversed by catalase, the NOX1/NOX4 inhibitor GKT137831, and Nox4 siRNA. Serotonin 0-4 NADPH oxidase 4 Rattus norvegicus 101-105 33794383-10 2021 Moreover, 5-HT and CH-induced proliferation and migration were suppressed by Nox4 or Trpm2 siRNA; and simultaneous transfection of both siRNA did not cause further inhibition. Serotonin 10-14 NADPH oxidase 4 Rattus norvegicus 77-81 6604123-5 1983 C3a and C3a des-arg were equally reactive in mediating platelet aggregation and release of serotonin. Serotonin 91-100 complement C3 Homo sapiens 0-3 6604123-5 1983 C3a and C3a des-arg were equally reactive in mediating platelet aggregation and release of serotonin. Serotonin 91-100 complement C3 Homo sapiens 8-11 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Serotonin 106-115 monoamine oxidase A Homo sapiens 4-23 6319457-11 1983 Finally it was observed that serotonin stimulated cyclic GMP levels; 10(-5) M serotonin optimally stimulated cyclic GMP with a spike of stimulation (6.1-fold) within 30 sec. Serotonin 29-38 5'-nucleotidase, cytosolic II Homo sapiens 57-60 6319457-11 1983 Finally it was observed that serotonin stimulated cyclic GMP levels; 10(-5) M serotonin optimally stimulated cyclic GMP with a spike of stimulation (6.1-fold) within 30 sec. Serotonin 78-87 5'-nucleotidase, cytosolic II Homo sapiens 57-60 6319457-11 1983 Finally it was observed that serotonin stimulated cyclic GMP levels; 10(-5) M serotonin optimally stimulated cyclic GMP with a spike of stimulation (6.1-fold) within 30 sec. Serotonin 78-87 5'-nucleotidase, cytosolic II Homo sapiens 116-119 6319457-12 1983 In summary, serotonin in palate cells stimulates both protein carboxyl methylation and cyclic GMP. Serotonin 12-21 5'-nucleotidase, cytosolic II Homo sapiens 94-97 33794383-11 2021 These results suggest that the 5-HT and CH-induced PASMC proliferation and migration were mediated, at least in part, by TRPM2 via activation of NOX4-dependent ROS production; and revealed a novel NOX4-ROS-TRPM2 signaling pathway for the pathogenesis of CHPH. Serotonin 31-35 NADPH oxidase 4 Rattus norvegicus 145-149 33794383-11 2021 These results suggest that the 5-HT and CH-induced PASMC proliferation and migration were mediated, at least in part, by TRPM2 via activation of NOX4-dependent ROS production; and revealed a novel NOX4-ROS-TRPM2 signaling pathway for the pathogenesis of CHPH. Serotonin 31-35 NADPH oxidase 4 Rattus norvegicus 197-201 33807811-3 2021 The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. Serotonin 81-100 5-hydroxytryptamine receptor 2C Homo sapiens 147-152 33807811-3 2021 The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. Serotonin 183-192 5-hydroxytryptamine receptor 2C Homo sapiens 147-152 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Serotonin 106-115 monoamine oxidase A Homo sapiens 25-29 17585061-2 2007 The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. Serotonin 106-115 monoamine oxidase A Homo sapiens 195-199 7175524-4 1982 The rank order of inhibition of serotonin uptake without Ca2+ was: Al3+ (IC50 = 370 microM) greater than Cd2+ (IC50 = 610 microM) greater than Mn2+ (IC50 = 3.4 mM) and the rank order in the presence of 1 mM Ca2+ was: Al3+ (IC50 = 290 microM) greater than Cd2+ (IC50 = 1.5 mM) greater than Mn2+ (IC50 = 4.0 mM). Serotonin 32-41 Cd2 molecule Rattus norvegicus 105-108 17337123-1 2007 Serotonin (5-HT) 5-HT1A receptor seems to play an important role in the pathophysiology of major depression and in the mechanism of action of antidepressants. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 17-32 7175524-4 1982 The rank order of inhibition of serotonin uptake without Ca2+ was: Al3+ (IC50 = 370 microM) greater than Cd2+ (IC50 = 610 microM) greater than Mn2+ (IC50 = 3.4 mM) and the rank order in the presence of 1 mM Ca2+ was: Al3+ (IC50 = 290 microM) greater than Cd2+ (IC50 = 1.5 mM) greater than Mn2+ (IC50 = 4.0 mM). Serotonin 32-41 Cd2 molecule Rattus norvegicus 255-258 7175524-5 1982 Ca2+, at 1 mM, definitely antagonized the inhibitory actions of Cd2+ on noradrenaline and serotonin uptake. Serotonin 90-99 Cd2 molecule Rattus norvegicus 64-67 7057191-5 1982 The Ki for 5-hydroxytryptamine as a competitive inhibitor of beta-phenethylamine oxidation by MAO-B was found to be 1400 microM. Serotonin 11-30 monoamine oxidase B Rattus norvegicus 94-99 17355134-7 2007 The conformational preferences of serotonin differ from those of tryptamine most notably in the selective stabilization observed for the Gph(out)/anti-OH conformer SERO(C), which makes it the second-most intense transition in the ultraviolet spectrum, surpassed only by the Gpy(out)/anti-OH conformer SERO(A). Serotonin 34-43 gephyrin Homo sapiens 137-140 6265598-3 1981 An overall increase in the synthesis of gangliosides more complex than GM3 was also observed in the mouse neuroblastoma x hamster brain explant hybrid cell line NCB-20 following elevation of cyclic AMP levels by treatment with serotonin and pargyline. Serotonin 227-236 granulocyte macrophage antigen 3 Mus musculus 71-74 17430111-3 2007 Enhanced tryptophan degradation by the enzyme indoleamine-2, 3-dioxygenase (IDO) contributes importantly to disease progression and "complications" of HIV infection: By a subsequent impairment of protein metabolism and serotonin formation, the development of neuropsychiatric disorders and weight loss in HIV infected patients can be enforced. Serotonin 219-228 indoleamine 2,3-dioxygenase 1 Homo sapiens 46-74 17430111-3 2007 Enhanced tryptophan degradation by the enzyme indoleamine-2, 3-dioxygenase (IDO) contributes importantly to disease progression and "complications" of HIV infection: By a subsequent impairment of protein metabolism and serotonin formation, the development of neuropsychiatric disorders and weight loss in HIV infected patients can be enforced. Serotonin 219-228 indoleamine 2,3-dioxygenase 1 Homo sapiens 76-79 7248106-0 1981 [Serum transaminase activity (GOT and GPT) in rats injected with serotonin]. Serotonin 65-74 glutamic--pyruvic transaminase Rattus norvegicus 38-41 17408646-8 2007 CONCLUSIONS: Our findings suggest an impact of allelic variation in 5-HT(1A) receptor expression on the development of interferon alfa-induced depression during antiviral treatment of chronic hepatitis C. Prediction models of interferon-induced depressive symptoms based on HTR1A variation offer a perspective for an antidepressant selective serotonin reuptake inhibitor prophylaxis in patients genetically at risk for interferon-induced depression. Serotonin 342-351 5-hydroxytryptamine receptor 1A Homo sapiens 68-85 6993660-3 1980 In response to stimulation by norepinephrine and serotonin, aortic strips from 2 to 28 day AHR developed the same tension as controls, whereas aortas of 6 and 14 day AHR had reduced maximal responses. Serotonin 49-58 aryl hydrocarbon receptor Rattus norvegicus 91-94 6993660-5 1980 Relaxation by isoproterenol and papaverine in serotonin-contracted aortas was the same in AHR and normotensive controls 2 and 28 days postoperatively but was reduced at 6 and 14 days. Serotonin 46-55 aryl hydrocarbon receptor Rattus norvegicus 90-93 17234339-5 2007 In monoaminergic neuronal B65 cells, which contain serotonin rather than dopamine, methamphetamine-induced cell death was also significantly but partially protected by transient transfection of PAG608 antisense cDNA. Serotonin 51-60 zinc finger, matrin type 3 Rattus norvegicus 194-200 6771334-5 1980 Inhibition of chymase by serotonin stored in its active site and of chymase and acid hydrolases by their interaction with heparin probably occurs. Serotonin 25-34 chymase 1 Rattus norvegicus 14-21 7225193-2 1980 Two arginine derivatives that were developed as thrombin inhibitors (TI-189 and TI-233) selectively inhibited the 5-hydroxytryptamine (5-HT)-induced contraction of rabbit aortic strips in a competitive manner. Serotonin 114-133 prothrombin Oryctolagus cuniculus 48-56 7225193-2 1980 Two arginine derivatives that were developed as thrombin inhibitors (TI-189 and TI-233) selectively inhibited the 5-hydroxytryptamine (5-HT)-induced contraction of rabbit aortic strips in a competitive manner. Serotonin 135-139 prothrombin Oryctolagus cuniculus 48-56 17295220-4 2007 Common alleles of some serotonin pathway genes, including those involved in its degradation (monoamine oxidase A, MAOA), or its re-uptake into pre-synaptic neurones (serotonin transporter, SERT) have been shown to confer functional variation. Serotonin 23-32 monoamine oxidase A Homo sapiens 114-118 17346140-1 2007 In this paper we report the study of tryptophan metabolism via serotonin in ventricular CSF in HIV-1 infection in order to investigate the origin of tryptophan metabolites in the human brain. Serotonin 63-72 colony stimulating factor 2 Homo sapiens 88-91 44380-0 1979 Effect of exogenous serotonin on intragastric pH and its influence on serum gastrin levels in rats. Serotonin 20-29 gastrin Rattus norvegicus 76-83 17346140-13 2007 This is the first report on the measurement of tryptophan metabolites via serotonin in ventricular CSF in HIV-1 infection. Serotonin 74-83 colony stimulating factor 2 Homo sapiens 99-102 44380-1 1979 The effect of various doses of serotonin on the serum gastrin levels and intragastric pH in rats, was studied. Serotonin 31-40 gastrin Rattus norvegicus 54-61 44380-2 1979 After serotonin administration of 10 mg/kg i.p., a significant increase in serum gastrin levels was noted, as well as a strong increase in the intragastric pH. Serotonin 6-15 gastrin Rattus norvegicus 81-88 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Serotonin 142-151 monoamine oxidase A Homo sapiens 0-19 44380-4 1979 These results suggest that the increase observed in serum gastrin levels after administration of exogenous serotonin is not mediated by increase in intragastric pH. Serotonin 107-116 gastrin Rattus norvegicus 58-65 17328795-3 2007 Monoamine oxidase A (MAO-A) encodes an enzyme that degrades biogenic amines, including neurotransmitters such as norepinephrine, dopamine and serotonin. Serotonin 142-151 monoamine oxidase A Homo sapiens 21-26 537285-9 1979 Treatment with the 5-HK analogues antagonized the contractile response to 5-hydroxytryptamine in a dose-dependent manner, the antagonistic potency being in the order of 5-HK greater than Cpd. Serotonin 74-93 carboxypeptidase D Canis lupus familiaris 187-190 16672106-3 2007 We previously reported that serotonin, a major neurotransmitter involved in mood disorders, regulates GSK3 by acutely increasing its N-terminal serine phosphorylation. Serotonin 28-37 glycogen synthase kinase 3 beta Mus musculus 102-106 378326-6 1979 Interactions of neurotensin with other neurotransmitter candidates are also suggested by its presence in areas enriched in norepinephrine, dopamine, serotonin, and substance P. Certain neurotensin localizations suggest an association of the peptide with functional brain systems preferentially involving these regions. Serotonin 149-158 neurotensin Rattus norvegicus 16-27 16979275-1 2007 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and selective serotonin reuptake inhibitors (SSRIs) exert their activity enhancing the general serotonergic tone. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 0-24 454816-1 1979 In incubation of rabbit platelets with ADF, adrenalin, serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides they show, determined with respect to malonic dialdehyde, rises simultaneously with the enhancement of aggregation activity. Serotonin 55-64 prothrombin Oryctolagus cuniculus 122-130 454816-1 1979 In incubation of rabbit platelets with ADF, adrenalin, serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides they show, determined with respect to malonic dialdehyde, rises simultaneously with the enhancement of aggregation activity. Serotonin 55-64 prothrombin Oryctolagus cuniculus 122-130 454816-1 1979 In incubation of rabbit platelets with ADF, adrenalin, serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides they show, determined with respect to malonic dialdehyde, rises simultaneously with the enhancement of aggregation activity. Serotonin 108-117 prothrombin Oryctolagus cuniculus 69-77 454816-1 1979 In incubation of rabbit platelets with ADF, adrenalin, serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides serotonin and thrombin the level of hydroxyperoxides they show, determined with respect to malonic dialdehyde, rises simultaneously with the enhancement of aggregation activity. Serotonin 108-117 prothrombin Oryctolagus cuniculus 69-77 16979275-1 2007 Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and selective serotonin reuptake inhibitors (SSRIs) exert their activity enhancing the general serotonergic tone. Serotonin 63-72 tryptophan hydroxylase 1 Homo sapiens 26-30 21204459-0 2007 The 5-HT1A Receptor: A Signaling Hub Linked to Emotional Balance Serotonin or 5-hydroxytryptamine (5-HT) is an ancient chemical that is synthesized in the brain and also in the peripheral system. Serotonin 65-74 5-hydroxytryptamine receptor 1A Homo sapiens 4-19 740049-8 1978 Both neurotensin and [Gln4]-neurotensin also accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine after inhibition of monoamine synthesis. Serotonin 106-125 neurotensin Rattus norvegicus 5-16 740049-8 1978 Both neurotensin and [Gln4]-neurotensin also accelerated the disappearance of dopamine, noradrenaline and 5-hydroxytryptamine after inhibition of monoamine synthesis. Serotonin 106-125 neurotensin Rattus norvegicus 28-39 659964-1 1978 HAL, a congener of clofibrate, has previously been shown to inhibit epinephrine- and ADP-induced platelet aggregation and 14C-serotonin release. Serotonin 126-135 histidine ammonia-lyase Homo sapiens 0-3 21204459-0 2007 The 5-HT1A Receptor: A Signaling Hub Linked to Emotional Balance Serotonin or 5-hydroxytryptamine (5-HT) is an ancient chemical that is synthesized in the brain and also in the peripheral system. Serotonin 78-97 5-hydroxytryptamine receptor 1A Homo sapiens 4-19 18320716-6 2007 As determined by HPLC, striatal dopamine (DA) and serotonin levels in mice treated with either MOG 35-55 in CFA or CFA alone were significantly higher compared to vehicle-treated controls on 13th day after induction. Serotonin 50-59 myelin oligodendrocyte glycoprotein Mus musculus 95-98 201683-0 1977 Elevation of the cyclic GMP concentration in human platelets by sodium ascorbate and 5-hydroxytryptamine. Serotonin 85-104 5'-nucleotidase, cytosolic II Homo sapiens 24-27 17046718-0 2007 Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain. Serotonin 92-101 solute carrier family 29 member 4 Homo sapiens 83-87 850134-1 1977 Although hydroxylation of tryptophan (TP) is considered to be the rate-limiting step in serotonin synthesis, the mechanism whereby tryptophan hydroxylase (TPH) participates in the regulation of serotonin synthesis is still in question. Serotonin 194-203 tryptophan hydroxylase 1 Rattus norvegicus 131-153 850134-1 1977 Although hydroxylation of tryptophan (TP) is considered to be the rate-limiting step in serotonin synthesis, the mechanism whereby tryptophan hydroxylase (TPH) participates in the regulation of serotonin synthesis is still in question. Serotonin 194-203 tryptophan hydroxylase 1 Rattus norvegicus 155-158 272843-4 1977 PRP of essential fatty acid deficient (EFAD) rats, however, generates far less PG-endoperoxide like activity, TXA2 and PGE, though the release of serotonin (5-HT) is unaltered. Serotonin 146-155 proline rich protein 2-like 1 Rattus norvegicus 0-3 24926868-3 2007 Initially, raised 5-HT levels, resulting from serotonin (5-HT) reuptake inhibition, over-activates the cell body 5-HT1A autoreceptor, which has an inhibitory effect on the neuronal firing rate. Serotonin 46-55 5-hydroxytryptamine receptor 1A Homo sapiens 113-119 812572-4 1976 When the amount of thrombin bound to platelets is related to the extent of 14C-serotonin release, bovine and human thrombin are equally effective. Serotonin 79-88 coagulation factor II, thrombin Bos taurus 19-27 934359-1 1976 The effect of graded doses of clorgyline, a preferential inhibitor of MAO A, and of deprenil, a preferential inhibitor of MAO B, on the activities of serotonin-deaminating MAO (MAO A) of dopamine-deaminating MAO, and of phenethylamine-deaminating MAO, (MAO B), in rat corpus striatum were compared with the effects of the drugs on striatal levels of homovanillic acid(HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC). Serotonin 150-159 monoamine oxidase B Rattus norvegicus 122-127 934359-1 1976 The effect of graded doses of clorgyline, a preferential inhibitor of MAO A, and of deprenil, a preferential inhibitor of MAO B, on the activities of serotonin-deaminating MAO (MAO A) of dopamine-deaminating MAO, and of phenethylamine-deaminating MAO, (MAO B), in rat corpus striatum were compared with the effects of the drugs on striatal levels of homovanillic acid(HVA) and 3,4-dihydroxyphenylacetic acid (DOPAC). Serotonin 150-159 monoamine oxidase B Rattus norvegicus 253-259 17570737-10 2007 CONCLUSION: While the study has several limitations, the results are consistent with a growing body of literature that suggests that the pharmacogenetics of depression (an inherently complex disorder) may turn out to be multifactorial, and may include the HTR1A gene in concert with other serotonin-related genes. Serotonin 289-298 5-hydroxytryptamine receptor 1A Homo sapiens 256-261 4814-0 1975 Alpha-MSH and MIF-2 effects on serotonin levels and accumulation in various rat brain areas. Serotonin 31-40 proopiomelanocortin Rattus norvegicus 0-9 18337624-6 2007 RESULTS: The CYR61-expressing cells mostly coincided with the serotonin-containing cells, not only in nontumoral epithelia, but also among tumor cells. Serotonin 62-71 cellular communication network factor 1 Homo sapiens 13-18 1221789-0 1975 Proceedings: The effect of LS 519 CL2 on the level and uptake of serotonin by thrombocytes. Serotonin 65-74 endogenous retrovirus group W member 5 Homo sapiens 34-37 2463-0 1975 Glutamine synthetase, glutaminase and phosphodiesterase activities in brain under hypoxia: in vitro effect of cortisol, GABA and serotonin on glutamine synthetase. Serotonin 129-138 glutamate-ammonia ligase Rattus norvegicus 142-162 34537284-11 2022 In inflammatory-mediated depression state, Rb1 improved impaired glucocorticoid receptor, suppressed indoleamine 2,3-dioxygenase activity, increased 5-HT level and 5-HT1A receptor expression. Serotonin 149-153 RB transcriptional corepressor 1 Mus musculus 43-46 18337624-11 2007 CONCLUSIONS: CYR61 is expressed in serotonin-containing cells, and downregulation of the expression might contribute to the progression of cancer by promoting MMP-7 expression in human gastric carcinomas. Serotonin 35-44 cellular communication network factor 1 Homo sapiens 13-18 4746448-0 1973 Influence of orphenadrine HC1 and its N-demethylated derivatives on the in vitro uptake of noradrenaline and 5-hydroxytryptamine by rat brain slices. Serotonin 109-128 Hypercalciuria QTL 1 Rattus norvegicus 26-29 34966948-10 2021 Thus, NF-alpha1/CPE uniquely interacts with serotonin receptor 5-HTR1E to activate the beta-arrestin/ERK/CREB/BCL2 pathway to mediate stress-induced neuroprotection. Serotonin 44-53 cAMP responsive element binding protein 1 Homo sapiens 105-109 16945529-2 2006 6-Oxygenated beta-carboline and beta-carbolinium derivatives based on the serotonin template were synthesized and tested in vitro for their ability to inhibit AChE and BChE, respectively. Serotonin 74-83 butyrylcholinesterase Homo sapiens 168-172 34976857-7 2021 In vitro simulation experiments further revealed that synchronization of microbial-driven serotonin rhythm and eating activity-driven body temperature oscillations, which are important zeitgebers, could promote the diurnal expression of clock genes and CLAUDIN-1 in rabbit intestinal epithelial cells (RIEC), and enhance RIEC proliferation. Serotonin 90-99 claudin-1 Oryctolagus cuniculus 253-262 34925531-7 2021 Besides, our results implied that PAE concentration-dependently promoted the content of 5-hydroxytryptamine (5-HT) catalyzed by tryptophan hydroxylase (Tph)-1 in the serum of loperamide-induced rats and in RIN-14B cells. Serotonin 88-107 tryptophan hydroxylase 1 Rattus norvegicus 128-158 34925531-7 2021 Besides, our results implied that PAE concentration-dependently promoted the content of 5-hydroxytryptamine (5-HT) catalyzed by tryptophan hydroxylase (Tph)-1 in the serum of loperamide-induced rats and in RIN-14B cells. Serotonin 109-113 tryptophan hydroxylase 1 Rattus norvegicus 128-158 4646034-0 1972 [Effect of reserpine and serotonin on hexokinase and cholinesterase activity in rat myocardium]. Serotonin 25-34 butyrylcholinesterase Rattus norvegicus 53-67 16455786-6 2006 Live post-FACS-sorted cells were cultured, and the effects of forskolin, isoproterenol, acetylcholine, GABAA, PACAP-38, and gastrin on serotonin secretion were measured by ELISA. Serotonin 135-144 gastrin Homo sapiens 124-131 4624450-2 1972 Staphylococcal protein A (SPA) causes rabbit platelet injury as manifested by release of platelet 5-hydroxytryptamine (5HT). Serotonin 98-117 pulmonary surfactant-associated protein A Oryctolagus cuniculus 0-24 4624450-2 1972 Staphylococcal protein A (SPA) causes rabbit platelet injury as manifested by release of platelet 5-hydroxytryptamine (5HT). Serotonin 98-117 pulmonary surfactant-associated protein A Oryctolagus cuniculus 26-29 4624450-2 1972 Staphylococcal protein A (SPA) causes rabbit platelet injury as manifested by release of platelet 5-hydroxytryptamine (5HT). Serotonin 119-122 pulmonary surfactant-associated protein A Oryctolagus cuniculus 0-24 4624450-2 1972 Staphylococcal protein A (SPA) causes rabbit platelet injury as manifested by release of platelet 5-hydroxytryptamine (5HT). Serotonin 119-122 pulmonary surfactant-associated protein A Oryctolagus cuniculus 26-29 5355978-0 1969 In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of C14-tryptophan to C14-5-hydroxytryptamine. Serotonin 23-42 anti-Mullerian hormone receptor type 2 Rattus norvegicus 97-100 5355978-0 1969 In vivo measurement of 5-hydroxytryptamine turnover rate in the rat brain from the conversion of C14-tryptophan to C14-5-hydroxytryptamine. Serotonin 23-42 anti-Mullerian hormone receptor type 2 Rattus norvegicus 115-118 5949137-0 1966 Distribution and placental transfer of C-14-serotonin in pregnant rats. Serotonin 44-53 anti-Mullerian hormone receptor type 2 Rattus norvegicus 39-43 34874128-0 2022 The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor. Serotonin 124-133 tryptophan hydroxylase 2 Rattus norvegicus 20-44 34874128-1 2022 BACKGROUND: Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase-2 (TPH2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation. Serotonin 242-261 tryptophan hydroxylase 2 Rattus norvegicus 154-178 34874128-1 2022 BACKGROUND: Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase-2 (TPH2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation. Serotonin 242-261 tryptophan hydroxylase 2 Rattus norvegicus 180-184 34874128-1 2022 BACKGROUND: Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase-2 (TPH2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation. Serotonin 263-267 tryptophan hydroxylase 2 Rattus norvegicus 154-178 34874128-1 2022 BACKGROUND: Although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (PE), tryptophan hydroxylase-2 (TPH2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-HT) and few studies have reported that brain TPH2 is involved in the regulation of ejaculation. Serotonin 263-267 tryptophan hydroxylase 2 Rattus norvegicus 180-184 34874128-6 2022 RESULTS: The results showed that the concentration of 5-HT and the expression of TPH2 in rapid rats were the lowest, while those in sluggish rats were the highest. Serotonin 54-58 tryptophan hydroxylase 2 Rattus norvegicus 81-85 34618686-7 2021 Enhanced 5-HT signaling through HTR2B directly activated lipolysis through phosphorylation of hormone sensitive lipase in visceral adipocytes. Serotonin 9-13 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 32-37 34618686-7 2021 Enhanced 5-HT signaling through HTR2B directly activated lipolysis through phosphorylation of hormone sensitive lipase in visceral adipocytes. Serotonin 9-13 lipase E, hormone sensitive type Homo sapiens 94-118 33219573-6 2021 The last to show Fgf8 lineage are those serotonin neurons in the lateral wings and those at the rostral-dorsal pole of dorsal raphe nucleus. Serotonin 40-49 fibroblast growth factor 8 Mus musculus 17-21 33219573-7 2021 Thus the temporal succession of Fgf8 lineage correlates with organizational features of serotonin neurons in these nuclei. Serotonin 88-97 fibroblast growth factor 8 Mus musculus 32-36 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Serotonin 78-87 monoamine oxidase A Homo sapiens 0-19 33913004-8 2021 The intravenous administration of serotonin increased significantly mesenteric lymph flow and the concentrations of albumin and IL-22; both were significantly reduced by the intravenous pretreatment with ketanserin. Serotonin 34-43 albumin Rattus norvegicus 116-123 33913004-10 2021 Additionally, serotonin in blood was found to increase mesenteric lymph formation with permeant albumin in the jejunal villi via the activation of 5-HT2 receptor. Serotonin 14-23 albumin Rattus norvegicus 96-103 34884655-0 2021 Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish (Danio rerio). Serotonin 102-106 tryptophan hydroxylase 1b Danio rerio 0-24 34884655-3 2021 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in 5-HT synthesis in the brain. Serotonin 63-67 tryptophan hydroxylase 1b Danio rerio 0-24 34884655-3 2021 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in 5-HT synthesis in the brain. Serotonin 63-67 tryptophan hydroxylase 1b Danio rerio 26-30 17088501-2 2006 Monoamine oxidase A (MAO-A) is an enzyme that metabolizes monoamines, such as serotonin, norepinephrine, and dopamine. Serotonin 78-87 monoamine oxidase A Homo sapiens 21-26 34797444-0 2021 Bacillus Subtilis Promotes the Release of 5-HT to Regulate Intestinal Peristalsis in STC Mice via Bile Acid and Its Receptor TGR5 Pathway. Serotonin 42-46 G protein-coupled bile acid receptor 1 Mus musculus 125-129 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Serotonin 137-146 monoamine oxidase A Homo sapiens 0-19 34797444-8 2021 The release of 5-HT from ECs and the bile acid receptor TGR5/TRPA1 pathway were significantly increased in STC mice treated with B. subtilis. Serotonin 15-19 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 61-66 34797444-10 2021 CONCLUSION: Bacillus subtilis regulates intestinal peristalsis of STC by promoting the release of 5-HT from ECs through bile acid metabolism and its receptor TGR5 pathway and plays a positive role in the treatment of STC. Serotonin 98-102 G protein-coupled bile acid receptor 1 Mus musculus 158-162 33625560-7 2021 The DA + /5-HT-group had c-Fos activation in areas related to anti-predatory defensive behaviors, such as the ventromedial hypothalamic nucleus, premammillary nucleus, and periaqueductal gray. Serotonin 10-14 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 25-30 33981243-7 2021 We confirmed the melatonin biosynthesis pathway"s molecular regulation dysfunctions, with a specific pattern for unipolar and bipolar depression, at the AANAT gene, its polymorphisms (rs8150 and rs3760138), and examined the serum biomarkers (serotonin, AANAT, ASMT, and melatonin). Serotonin 242-251 aralkylamine N-acetyltransferase Homo sapiens 153-158 34828419-8 2021 It was shown for the first time that, in both groups of experimental mice, the changes in the transcription of genes controlling the synthesis and transport of serotonin directly correlate with the expression of genes Crh and Trh, which control the synthesis of corticotrophin- and thyrotropin-releasing hormones. Serotonin 160-169 corticotropin releasing hormone Mus musculus 218-221 16896926-1 2006 Monoamine oxidase A (MAOA) catalyses the oxidative deamination of biogenic amines including neurotransmitters, mainly norepinephrine and serotonin in the brain and peripheral tissues. Serotonin 137-146 monoamine oxidase A Homo sapiens 21-25 34828419-8 2021 It was shown for the first time that, in both groups of experimental mice, the changes in the transcription of genes controlling the synthesis and transport of serotonin directly correlate with the expression of genes Crh and Trh, which control the synthesis of corticotrophin- and thyrotropin-releasing hormones. Serotonin 160-169 thyrotropin releasing hormone Mus musculus 226-229 34828419-8 2021 It was shown for the first time that, in both groups of experimental mice, the changes in the transcription of genes controlling the synthesis and transport of serotonin directly correlate with the expression of genes Crh and Trh, which control the synthesis of corticotrophin- and thyrotropin-releasing hormones. Serotonin 160-169 thyrotropin releasing hormone Mus musculus 262-312 33935664-7 2021 Thus, the reduction of 5-HT in fruit flies" brains may be the mechanistic basis of an adaptive bet-hedging strategy in a less predictable boreal climate. Serotonin 23-27 bet Drosophila melanogaster 95-98 33935645-0 2021 Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory. Serotonin 76-85 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 13-17 33935645-6 2021 Our data indicates that BDNF-TrkB signaling regulates the functional phenotype of 5-HT neurons with long-term behavioral consequences. Serotonin 82-86 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 29-33 34782755-1 2021 The Dutch Pharmacogenetics Working Group (DPWG) guideline presented here, presents the gene-drug interaction between the genes CYP2C19 and CYP2D6 and antidepressants of the selective serotonin reuptake inhibitor type (SSRIs). Serotonin 183-192 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 127-134 16934536-1 2006 The past 20 years have seen notable advances in our understanding of the physiology and pharmacology of the emetic reflex leading to the identification of the anti-emetic effects of 5-hydroxytryptamine(3) (5-HT(3)) and neurokinin(1) receptor (NK(1)) antagonists. Serotonin 182-201 tachykinin receptor 1 Homo sapiens 243-248 34834271-3 2021 The aim of this work was to characterize the serotonin receptor 5-HT4 in the hCMEC/D3 cell line, in the rat and the human BBB. Serotonin 45-54 5-hydroxytryptamine receptor 4 Homo sapiens 64-69 33859334-8 2021 5-HT-mediated extravasation was significantly reduced by pharmacological inhibition of the 5-HT2A receptor subtype, or with antagonism or deletion of TRPV4, consistent with functional interaction between 5-HT receptors and TRPV4. Serotonin 0-4 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 91-106 33404066-0 2021 Serotonin depletion during the postnatal developmental period causes behavioral and cognitive alterations and decreases BDNF level in the brain of rats. Serotonin 0-9 brain-derived neurotrophic factor Rattus norvegicus 120-124 33404066-8 2021 In addition, postnatal days serotonin depletion decreased BDNF level in the hippocampus and PFC of both male and female rats. Serotonin 28-37 brain-derived neurotrophic factor Rattus norvegicus 58-62 16781815-6 2006 However, the demonstration of both serotonin, and dopamine beta hydroxylase immunoreactive terminals on both parasympathetic and sympathetic preganglionic neurones provides evidence for direct modulation of these cells by both serotonin and norepinephrine. Serotonin 227-236 dopamine beta-hydroxylase Rattus norvegicus 50-75 33712280-9 2021 STX3 knockdown marginally but significantly decreased the serotonin uptake activity of Caco-2 cells, suggesting that STX3 positively regulates SERT function in Caco-2 cells, as opposed to SERT regulation by STX3 in overexpressing cells. Serotonin 58-67 syntaxin 3 Homo sapiens 0-4 33712280-9 2021 STX3 knockdown marginally but significantly decreased the serotonin uptake activity of Caco-2 cells, suggesting that STX3 positively regulates SERT function in Caco-2 cells, as opposed to SERT regulation by STX3 in overexpressing cells. Serotonin 58-67 syntaxin 3 Homo sapiens 117-121 33712280-9 2021 STX3 knockdown marginally but significantly decreased the serotonin uptake activity of Caco-2 cells, suggesting that STX3 positively regulates SERT function in Caco-2 cells, as opposed to SERT regulation by STX3 in overexpressing cells. Serotonin 58-67 syntaxin 3 Homo sapiens 117-121 34118174-1 2021 Fluoxetine is a selective serotonin reuptake inhibitor that is metabolized to norfluoxetine by CYP2D6, CYP2C19, and CYP3A4. Serotonin 26-35 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 103-110 34720020-1 2021 INTRODUCTION: Alterations in the activity of tryptophan 2,3-dioxygenase (TDO) cause imbalances in the levels of serotonin and other neuroactive metabolites which can contribute to motor, psychiatric, gastrointestinal, and other dysfunctions often seen in Parkinson"s disease (PD). Serotonin 112-121 tryptophan 2,3-dioxygenase Homo sapiens 45-71 34720020-1 2021 INTRODUCTION: Alterations in the activity of tryptophan 2,3-dioxygenase (TDO) cause imbalances in the levels of serotonin and other neuroactive metabolites which can contribute to motor, psychiatric, gastrointestinal, and other dysfunctions often seen in Parkinson"s disease (PD). Serotonin 112-121 tryptophan 2,3-dioxygenase Homo sapiens 73-76 16770335-2 2006 Monoamine oxidase A deaminates the monoamine neurotransmitters serotonin, dopamine (DA), and noradrenaline. Serotonin 63-72 monoamine oxidase A Homo sapiens 0-19 34452265-3 2021 We hypothesize that antidepressants disturb serotonin homeostasis in the fetoplacental unit by inhibiting serotonin transporter (SERT) and organic cation transporter 3 (OCT3) in the maternal- and fetal-facing placental membranes, respectively. Serotonin 44-53 OCTN3 Homo sapiens 139-167 34452265-3 2021 We hypothesize that antidepressants disturb serotonin homeostasis in the fetoplacental unit by inhibiting serotonin transporter (SERT) and organic cation transporter 3 (OCT3) in the maternal- and fetal-facing placental membranes, respectively. Serotonin 44-53 OCTN3 Homo sapiens 169-173 34452265-5 2021 All tested antidepressants significantly inhibited SERT- and OCT3-mediated serotonin uptake in a dose-dependent manner. Serotonin 75-84 OCTN3 Homo sapiens 61-65 33607146-7 2021 Autoradiographic quantification of serotonin transporters showed that both the TDO inhibitor 680C91 and the AhR antagonist CH-223191 potentiated the neurotoxicity induced by MDMA, while administration of exogenous L-kynurenine or of the AhR positive modulator 3,3"-diindolylmethane (DIM) partially prevented the serotonergic damage induced by the drug. Serotonin 35-44 aryl hydrocarbon receptor Rattus norvegicus 108-111 33789079-7 2021 Since 5-HT2AR signaling is involved in the etiology of different psychiatric disorders and mediates the psychological effects of many psychoactive serotonergic drugs, we propose that the newly discovered link between Sst interneurons and 5-HT will contribute to our understanding of these complex topics. Serotonin 6-10 somatostatin Homo sapiens 217-220 16944667-5 2006 We hypothesized that the risk of sleep disturbance is, at least in part, influenced by the availability of serotonin used for melatonin synthesis secondary to polymorphic variation at the enzyme monoamine oxidase A (MAO-A). Serotonin 107-116 monoamine oxidase A Homo sapiens 195-214 33705592-0 2021 Estrogen and serotonin enhance stress-induced visceral hypersensitivity in female rats by up-regulating brain-derived neurotrophic factor in spinal cord. Serotonin 13-22 brain-derived neurotrophic factor Rattus norvegicus 104-137 34452265-10 2021 As accurate fetal programming requires optimal serotonin levels in the fetoplacental unit throughout gestation, inhibition of SERT-/OCT3-mediated serotonin uptake may help explain the poor outcomes of antidepressant use in pregnancy. Serotonin 146-155 OCTN3 Homo sapiens 132-136 34440174-9 2021 The results show that 5-HT is not involved in the development of oxaliplatin-induced allodynia, but increasing the activity of the 5-HT1A, 5-HT2A, and 5-HT3 receptors and decreasing the action of 5-HT2C and 5-HT6 receptors may help inhibit pain. Serotonin 22-26 5-hydroxytryptamine receptor 2C Homo sapiens 196-202 34246927-13 2021 Whereas, OB-induced behavioral changes were attenuated, which were associated with increasing 5-HT turnover, decrease macrophage activity, restored S100beta/BDNF and n-3/n-6 PUFAs ratios, and total cholesterol concentrations in Fat-1 mice. Serotonin 94-98 FAT atypical cadherin 1 Mus musculus 228-233 33536244-3 2021 Here, we uncovered a signaling pathway involving the adhesion molecule L1 and serotonin receptor 5-HT4 (5-HT4R). Serotonin 78-87 5-hydroxytryptamine receptor 4 Homo sapiens 97-102 33536244-3 2021 Here, we uncovered a signaling pathway involving the adhesion molecule L1 and serotonin receptor 5-HT4 (5-HT4R). Serotonin 78-87 5-hydroxytryptamine receptor 4 Homo sapiens 104-110 16944667-5 2006 We hypothesized that the risk of sleep disturbance is, at least in part, influenced by the availability of serotonin used for melatonin synthesis secondary to polymorphic variation at the enzyme monoamine oxidase A (MAO-A). Serotonin 107-116 monoamine oxidase A Homo sapiens 216-221 34282222-3 2021 We recently found that fluoxetine, a selective serotonin (5-HT) reuptake inhibitor and antidepressant drug, fully rescued motor coordination deficits in Mecp2 heterozygous (Mecp2 HET) mice acting through brain 5-HT. Serotonin 210-214 NADPH oxidase 3 Mus musculus 179-182 16728402-1 2006 Monoamine oxidase (MAO) A is a key enzyme for the degradation of neurotransmitters serotonin, norepinephrine, and dopamine. Serotonin 83-92 monoamine oxidase A Homo sapiens 0-25 34282222-8 2021 These findings suggest that boosting 5-HT transmission is sufficient to enhance the expression of MeCP2 in several brain regions of Mecp2 HET mice. Serotonin 37-41 NADPH oxidase 3 Mus musculus 138-141 33603523-4 2021 Serotonin/T-HydroxyTriptamine (5-HT) plays a key role in ventilatory stimulation, while the polymorphism of the serotonin transporter gene (STG) leads to alterations in serotonin level, making it important in OSA. Serotonin 112-121 chromosome 6 open reading frame 15 Homo sapiens 140-143 33628192-5 2021 Molecular and morphological evidence showed that chronic MA administration reduced the expression of the 5-hydroxytryptamine (5-HT) rate-limiting enzyme, tryptophan hydroxylase 2, in the dorsal raphe and the concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid in the basolateral amygdala (BLA) nuclei. Serotonin 105-124 tryptophan hydroxylase 2 Homo sapiens 154-178 34231053-2 2022 Clinical guidelines provide recommendations for selective serotonin reuptake inhibitor (SSRI) drug choice and dose based on CYP2D6 and CYP2C19 genotype; however, they are based on evidence from non-pregnant cohorts. Serotonin 58-67 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 135-142 17029036-2 2006 Brain-derived neurotrophic factor (BDNF) supports serotonergic neuronal development and our recent study found that heterozygous mice lacking one BDNF gene allele interbred with male serotonin transporter (SERT) knockout mice had greater reductions in brain tissue serotonin concentrations, greater increases in anxiety-like behaviors and greater ACTH responses to stress than found in the SERT knockout mice alone. Serotonin 183-192 brain derived neurotrophic factor Mus musculus 0-33 33628192-5 2021 Molecular and morphological evidence showed that chronic MA administration reduced the expression of the 5-hydroxytryptamine (5-HT) rate-limiting enzyme, tryptophan hydroxylase 2, in the dorsal raphe and the concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid in the basolateral amygdala (BLA) nuclei. Serotonin 126-130 tryptophan hydroxylase 2 Homo sapiens 154-178 17029036-2 2006 Brain-derived neurotrophic factor (BDNF) supports serotonergic neuronal development and our recent study found that heterozygous mice lacking one BDNF gene allele interbred with male serotonin transporter (SERT) knockout mice had greater reductions in brain tissue serotonin concentrations, greater increases in anxiety-like behaviors and greater ACTH responses to stress than found in the SERT knockout mice alone. Serotonin 183-192 brain derived neurotrophic factor Mus musculus 35-39 32901992-5 2021 Real-time reverse transcription-polymerase chain reaction analysis showed that murine aortic valve interstitial cells (VICs) expressed both serotonin receptor types 2A and 2B (Htr2a and Htr2b). Serotonin 140-149 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 176-181 32901992-7 2021 5-HT also augmented TNF-alpha-induced osteoblastic differentiation and matrix mineralization of VIC, but 5-HT alone had no effects. Serotonin 0-4 endothelin 2 Mus musculus 96-99 17029036-11 2006 These findings support the hypothesis that estrogen may enhance BDNF function via its TrkB receptor, leading to alterations in the serotonin circuits, which modulate anxiety-like behaviors. Serotonin 131-140 brain derived neurotrophic factor Mus musculus 64-68 32901992-8 2021 Inhibition of serotonin receptor type 2B, using specific inhibitors or lentiviral knockdown in VIC, attenuated 5-HT effects on TNF-alpha-induced osteoblastic differentiation and mineralization. Serotonin 14-23 endothelin 2 Mus musculus 95-98 32901992-8 2021 Inhibition of serotonin receptor type 2B, using specific inhibitors or lentiviral knockdown in VIC, attenuated 5-HT effects on TNF-alpha-induced osteoblastic differentiation and mineralization. Serotonin 111-115 endothelin 2 Mus musculus 95-98 32901992-9 2021 5-HT treatment also augmented TNF-alpha-induced matrix metalloproteinase-3 expression, which was also attenuated by Htr2b knockdown. Serotonin 0-4 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 116-121 34131274-5 2021 Importantly, these effects are mediated by serotonin signaling, as a mutation in serotonin receptor 2A (5-HT2A) eliminated the effects of nutrient choice. Serotonin 43-52 5-hydroxytryptamine (serotonin) receptor 1A Drosophila melanogaster 81-102 16652315-3 2006 The concomitant administration of nonselective MAO inhibitors or MAO-A inhibitors with drugs that increase serotonin concentrations is associated with serotonin toxicity. Serotonin 107-116 monoamine oxidase A Homo sapiens 65-70 34066363-3 2021 A ~50 nm-thick nafion-200-nm-thick MWCNT-modified BDUNCD microelectrode provided an excellent combination of sensitivity and selectivity for the detection of dopamine (DA; 6.75 muA muM-1 cm-2) and serotonin (5-HT; 4.55 muA muM-1 cm-2) in the presence of excess amounts of ascorbic acid (AA), the most common interferent. Serotonin 208-212 PWWP domain containing 3A, DNA repair factor Homo sapiens 223-228 34104992-3 2021 One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine. Serotonin 261-270 OCTN3 Homo sapiens 139-167 34104992-3 2021 One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine. Serotonin 261-270 OCTN3 Homo sapiens 169-173 33243689-1 2021 BACKGROUND: We previously reported that the combination of the dopamine (DA) receptor agonist apomorphine and the 5-hydroxytryptamine (5-HT2) receptor agonist m-chlorophenylpiperazine (m-CPP) in rats potently and selectively facilitates the ejaculatory response through activation of D2-like and 5-HT2C receptors, respectively. Serotonin 114-133 5-hydroxytryptamine receptor 2C Rattus norvegicus 284-302 32956676-6 2021 The present studies focused on the initial characterization of a novel atypical DAT inhibitor, CT-005404, which binds to DAT with high selectivity relative to serotonin and norepinephrine transport, and produces long-term elevations of extracellular DA. Serotonin 159-168 solute carrier family 6 member 3 Homo sapiens 80-83 16652315-3 2006 The concomitant administration of nonselective MAO inhibitors or MAO-A inhibitors with drugs that increase serotonin concentrations is associated with serotonin toxicity. Serotonin 151-160 monoamine oxidase A Homo sapiens 65-70 34980821-0 2021 5-HT2A, 5-HT1B/D, 5HT3 and 5-HT7 receptors as mediators of serotonin-induced direct contractile response of bovine airway smooth muscle. Serotonin 59-68 5-hydroxytryptamine receptor 2A Bos taurus 0-6 16819984-0 2006 Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus. Serotonin 79-88 tachykinin receptor 1 Rattus norvegicus 49-69 33188842-1 2021 The complexity of oxytocin-mediated functions is strongly associated with its modulatory effects on other neurotransmission systems, including the serotonin (5-hydroxytryptamine, 5-HT) system. Serotonin 147-156 oxytocin Mus musculus 18-26 16819984-2 2006 In rodents, treatment with NK1r antagonists has been shown to increase the firing of dorsal raphe nucleus (DRN) serotonin (5-hydroxytryptamine, 5-HT) neurons and to induce a desensitization of their 5-HT1A autoreceptors, suggesting local interactions between the SP and 5-HT systems. Serotonin 112-121 tachykinin receptor 1 Rattus norvegicus 27-31 33188842-1 2021 The complexity of oxytocin-mediated functions is strongly associated with its modulatory effects on other neurotransmission systems, including the serotonin (5-hydroxytryptamine, 5-HT) system. Serotonin 158-177 oxytocin Mus musculus 18-26 33188842-1 2021 The complexity of oxytocin-mediated functions is strongly associated with its modulatory effects on other neurotransmission systems, including the serotonin (5-hydroxytryptamine, 5-HT) system. Serotonin 179-183 oxytocin Mus musculus 18-26 35367299-11 2022 The expression of IgfII and SynIIb increased in males and decreased in females and the expression of serotonin receptor Htr2A did not change in both genders. Serotonin 101-110 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 120-125 16819984-2 2006 In rodents, treatment with NK1r antagonists has been shown to increase the firing of dorsal raphe nucleus (DRN) serotonin (5-hydroxytryptamine, 5-HT) neurons and to induce a desensitization of their 5-HT1A autoreceptors, suggesting local interactions between the SP and 5-HT systems. Serotonin 123-142 tachykinin receptor 1 Rattus norvegicus 27-31 16298130-3 2006 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinities at the 5-HT1A receptor and serotonin reuptake site in vitro. Serotonin 139-148 5-hydroxytryptamine receptor 1A Homo sapiens 119-134 35253069-2 2022 The serotonin 5-HT2A receptor agonist N,N-dimethyltryptamine (DMT) is the main psychoactive component of ayahuasca, suggesting that its therapeutic effects may be mediated by 5-HT2A receptors. Serotonin 4-13 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 175-181 35452231-5 2022 To systematically assess GPCR signaling in response to serotonin, we characterized reporter gene expression at two different pHs of a 144-sized library encoding all 12 human serotonin GPCRs in combination with 12 different Galpha proteins engineered in yeast. Serotonin 55-64 vomeronasal 1 receptor 17 pseudogene Homo sapiens 25-29 32745213-3 2021 Several awake-active neurotransmitters with inputs to the HMN (e.g., serotonin, 5-HT) inhibit K+ leak mediated by TASK-1/3 channels on hypoglossal motoneurons, leading to increased neuronal activity in-vitro. Serotonin 69-78 potassium two pore domain channel subfamily K member 3 Rattus norvegicus 114-122 32745213-3 2021 Several awake-active neurotransmitters with inputs to the HMN (e.g., serotonin, 5-HT) inhibit K+ leak mediated by TASK-1/3 channels on hypoglossal motoneurons, leading to increased neuronal activity in-vitro. Serotonin 80-84 potassium two pore domain channel subfamily K member 3 Rattus norvegicus 114-122 33448546-11 2021 CONCLUSIONS AND INFERENCES: F1-7, F34-3, and FWDG promoted 5-HT secretion in ECs of constipation mice by activating the CGA/ADRalpha2A cascade signal and regulating the TRP/TPH-OR pathways. Serotonin 59-63 chromogranin A Mus musculus 120-123 33126185-5 2021 The constructed electrochemical sensor for the detection of 5-hydroxytryptamine (STN) showed a wide working range (0.1-522.6 muM), high sensitivity (19.377 muA muM-1 cm-2), and nano-molar detection limit (3.1 nM). Serotonin 60-79 PWWP domain containing 3A, DNA repair factor Homo sapiens 160-165 16508167-0 2006 Involvement of leptin in hypophagia induced by the serotonin precursor 5-hydroxytryptophan (5-HTP) in mice. Serotonin 51-60 leptin Mus musculus 15-21 33002595-7 2020 Oppositely, fluvoxamine and sertraline, agents belonging to the class of selective serotonin reuptake inhibitor, upregulated the PGE1-stimulated release of both OPG and IL-6. Serotonin 83-92 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 161-164 35585132-10 2022 Human neuroblastoma SH-SY5Y cells incubated with bacteria-free mouse colonic supernatant, 5-HT, nerve growth factor, or brain-derived neurotrophic factor exhibited nerve fibre elongation, which was inhibited by 5-HT7 antagonists. Serotonin 90-94 basigin Mus musculus 213-216 35585132-13 2022 A positive-feedback loop was observed between serotonin and neurotrophin pathways via 5-HT7 activation to aggravate fibre elongation, whereby 5-HT3 and 5-HT4 had no roles. Serotonin 46-55 basigin Mus musculus 88-91 35585132-13 2022 A positive-feedback loop was observed between serotonin and neurotrophin pathways via 5-HT7 activation to aggravate fibre elongation, whereby 5-HT3 and 5-HT4 had no roles. Serotonin 46-55 hypothermia due to alcohol sensitivity 3 Mus musculus 144-147 35600957-0 2022 The 5-HT and PLC Signaling Pathways Regulate the Secretion of IL-1beta, TNF-alpha and BDNF from NG2 Cells. Serotonin 4-8 brain-derived neurotrophic factor Rattus norvegicus 86-90 35545425-6 2022 5HT effect on TRH mRNA was not affected by PKA inhibition, but it diminished in the presence of PKCi suggesting involvement of PKC in 5HT-induced TRH increased transcription. Serotonin 0-3 thyrotropin releasing hormone Mus musculus 14-17 35545425-6 2022 5HT effect on TRH mRNA was not affected by PKA inhibition, but it diminished in the presence of PKCi suggesting involvement of PKC in 5HT-induced TRH increased transcription. Serotonin 134-137 thyrotropin releasing hormone Mus musculus 146-149 16508167-1 2006 We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. Serotonin 34-43 leptin Mus musculus 105-111 35614949-9 2022 Moreover, the system pharmacology assays were used to assess the physiological targets involved in the action of CKF, with results suggesting that CKF putatively functioned through the 5-HT-PKA-CREB-BDNF pathway. Serotonin 185-189 brain-derived neurotrophic factor Rattus norvegicus 199-203 33138259-2 2020 The bulk of dietary TRP flows into the synthesis of body"s proteins, but the TRP metabolism also involves several biochemical reactions (i.e., serotonin and kynurenine pathways). Serotonin 143-152 transient receptor potential cation channel subfamily C member 5 Bos taurus 77-80 16508167-1 2006 We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. Serotonin 45-49 leptin Mus musculus 105-111 16530518-7 2006 BDNF stimulated and immunoneutralization of endogenous BDNF reduced ascending contraction and descending relaxation of circular muscle and release of serotonin and calcitonin gene-related peptide during the peristaltic reflex induced by mucosal stimulation but not muscle stretch. Serotonin 150-159 brain derived neurotrophic factor Mus musculus 55-59 33122957-3 2020 Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. Serotonin 95-99 solute carrier family 6 member 3 Homo sapiens 0-20 33122957-3 2020 Dopamine transporter (DAT) and serotonin transporter play a key role in the reuptake of DA and 5-HT from the synaptic cleft into presynaptic neurons. Serotonin 95-99 solute carrier family 6 member 3 Homo sapiens 22-25 33082287-3 2020 Here, we showed that the class A serotonin 5-HT2A receptors (5-HT2ARs) affected the localization and trafficking of class C metabotropic glutamate receptor 2 (mGluR2) through a mechanism that required their assembly as heteromers in mammalian cells. Serotonin 33-42 glutamate metabotropic receptor 2 Homo sapiens 124-157 35550066-6 2022 5-HT receptors HTR1B/1D/1F are highly expressed in colorectal CSCs and engage with 5-HT to initiate Wnt/beta-catenin signaling. Serotonin 0-4 catenin (cadherin associated protein), beta 1 Mus musculus 104-116 35550066-6 2022 5-HT receptors HTR1B/1D/1F are highly expressed in colorectal CSCs and engage with 5-HT to initiate Wnt/beta-catenin signaling. Serotonin 83-87 catenin (cadherin associated protein), beta 1 Mus musculus 104-116 35391733-6 2022 Intriguingly, Tryptophan hydroxylase 2 (TPH2), the neuronal specific rate-limiting enzyme for serotonin synthesis, was the most significantly upregulated gene by HSV in an amino acid metabolism PCR array. Serotonin 94-103 tryptophan hydroxylase 2 Homo sapiens 14-38 35391733-6 2022 Intriguingly, Tryptophan hydroxylase 2 (TPH2), the neuronal specific rate-limiting enzyme for serotonin synthesis, was the most significantly upregulated gene by HSV in an amino acid metabolism PCR array. Serotonin 94-103 tryptophan hydroxylase 2 Homo sapiens 40-44 35391733-10 2022 HSV infection induced expression of the critical serotonin synthesis enzymes TPH-1, TPH-2, and DOPA decarboxylase (DDC), as well as the serotonin transporter, SERT. Serotonin 49-58 tryptophan hydroxylase 2 Homo sapiens 84-89 16408297-1 2006 BDNF is thought to provide critical trophic support for serotonin neurons. Serotonin 56-65 brain derived neurotrophic factor Mus musculus 0-4 35235945-2 2022 Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal. Serotonin 0-9 tryptophan 5-hydroxylase 1 Capra hircus 99-123 35235945-2 2022 Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal. Serotonin 0-9 tryptophan 5-hydroxylase 1 Capra hircus 125-129 35235945-2 2022 Serotonin (5-hydroxytryphtamine, 5-HT), the product of 5-hydroxy-l-tryptophan (5-HTP) catalysed by tryptophan hydroxylase 1 (TPH1), is a multifunctional monoamine thought to be a homeostatic regulator of the animal. Serotonin 33-37 tryptophan 5-hydroxylase 1 Capra hircus 99-123 32968778-6 2020 This module was mainly expressed by interneurons, pyramidal CA1, and pyramidal SS cells, and pathway analysis showed association with hormonal signalling (thyrotropin-releasing hormone receptor and oxytocin receptor signalling pathways), Alzheimer"s disease pathway, serotonin receptor pathway and general heterotrimeric G-protein signalling pathways. Serotonin 267-276 carbonic anhydrase 1 Homo sapiens 60-63 16408297-9 2006 These findings suggest that postnatal levels of BDNF play a relatively limited role in maintaining presynaptic aspects of the serotonin system and a much greater role in maintaining postsynaptic 5-HT2A and possibly other receptors than previously suspected. Serotonin 126-135 brain derived neurotrophic factor Mus musculus 48-52 32485258-0 2020 Cholesterol-mediated oligomerization pathways of serotonin G-coupled receptor 5-HT2C. Serotonin 49-58 5-hydroxytryptamine receptor 2C Homo sapiens 78-84 35094016-1 2022 BACKGROUND: Variation within the CYP2C19 gene has been linked to differential metabolism of selective serotonin reuptake inhibitors (SSRIs). Serotonin 102-111 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 33-40 16165107-1 2006 BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Serotonin 92-101 tryptophan hydroxylase 1 Homo sapiens 12-35 35115687-5 2022 The new risk loci include genes encoding recent migraine-specific drug targets, namely calcitonin gene-related peptide (CALCA/CALCB) and serotonin 1F receptor (HTR1F). Serotonin 137-146 5-hydroxytryptamine receptor 1F Homo sapiens 160-165 32870377-5 2020 In the epithelium, HTR2A, HTR2B, and HTR4 colocalized with 5-HT, and HTR4 colocalized with glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). Serotonin 59-63 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 19-24 32870377-5 2020 In the epithelium, HTR2A, HTR2B, and HTR4 colocalized with 5-HT, and HTR4 colocalized with glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). Serotonin 59-63 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 26-31 32870377-6 2020 Murine intestinal organoids show a colocalization pattern that is similar to in vivo HTR2A and HTR4 with 5-HT, GLP-1, and PYY. Serotonin 105-109 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 85-90 32999279-5 2020 5-HT synapses and synaptic triads were identified as synaptophysin-stained sites on 5-HT axons located proximal to gephyrin-stained or PSD95-stained spines. Serotonin 0-4 discs large MAGUK scaffold protein 4 Mus musculus 135-140 16401478-8 2006 GLP-2R protein was co-localized by confocal immunohistochemistry with serotonin in enteroendocrine cells and also with endothelial nitric oxide synthase (eNOS)-expressing and vasoactive intestinal polypeptide-positive enteric neurons. Serotonin 70-79 glucagon like peptide 2 receptor Sus scrofa 0-6 32981537-0 2021 Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a TPH2 imaging genetics approach. Serotonin 0-9 tryptophan hydroxylase 2 Homo sapiens 103-107 35163491-0 2022 Contribution of the STAT Family of Transcription Factors to the Expression of the Serotonin 2B (HTR2B) Receptor in Human Uveal Melanoma. Serotonin 82-91 signal transducer and activator of transcription 1 Homo sapiens 20-24 16336631-3 2006 An endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, an MAO-A inhibitor, reduced membrane potential, DeltaPsim, in isolated mitochondria, and induced apoptosis in the cells, which 5-hydroxytryptamine, an MAO-A substrate, prevented. Serotonin 189-208 monoamine oxidase A Homo sapiens 65-70 35087467-2 2021 Previous studies have suggested a potential role of the tryptophan-serotonin (5-HT)-kynurenine (TSK) axis in ischemic stroke. Serotonin 67-76 tsukushi, small leucine rich proteoglycan Homo sapiens 96-99 35240891-4 2022 5-HT2A is a G protein-coupled receptor and it is involved in 5-HT descending pain modulation system. Serotonin 61-65 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 0-6 32978487-2 2020 On the other hand, increased expression of hepatic serotonin receptor 2a (htr2a) in diet-induced obesity contributes to hepatosteatosis. Serotonin 51-60 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 74-79 32895458-3 2020 Recent studies described that serotonin (5-HT) inhibits benign prostate growth through the modulation of the androgen receptor, in the presence of TES. Serotonin 30-39 androgen receptor Mus musculus 109-126 32895458-3 2020 Recent studies described that serotonin (5-HT) inhibits benign prostate growth through the modulation of the androgen receptor, in the presence of TES. Serotonin 41-45 androgen receptor Mus musculus 109-126 32769108-3 2020 The CeA receives dense innervation from the dorsal raphe nucleus, the major source of 5-HT, and expresses 5-HT-receptor subtypes (e.g., 5-HT2C and 5-HT1A) critically linked to AUD. Serotonin 106-110 5-hydroxytryptamine receptor 2C Rattus norvegicus 136-142 2476913-0 1989 Increased levels of substance P and cholecystokinin in rat cerebral cortex following repeated electroconvulsive shock and subchronic treatment with a serotonin uptake inhibitor. Serotonin 150-159 cholecystokinin Rattus norvegicus 36-51 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Serotonin 181-190 monoamine oxidase A Homo sapiens 0-26 2815668-1 1989 Dissimilar effect of emotional stress on activity of the A and B forms of brain monoamine oxidase (MAO) was found in motionless rats within 1 and 5 hrs: increase in the rate of serotonin deamination catalyzed by MAO A and decrease in the rate of catalyzed by MAO B benzylamine deamination. Serotonin 177-186 monoamine oxidase B Rattus norvegicus 259-264 2815668-3 1989 Both low 10(-11) 10(-13) M and high 10(-5) 10(-6) M concentrations of corticosterone stimulated the MAO A deamination of serotonin, while the steroid high concentrations inhibited the MAO B deamination of benzylamine either in vitro and in vivo (after intraperitoneal administration of 5 mg/kg). Serotonin 121-130 monoamine oxidase B Rattus norvegicus 184-189 32446903-11 2020 Restoration of lncRNA XIST resulted in increased AWR score, counts of peristaltic wave, abdominal wall contraction and defecation particles along with stimulated 5-HT expression and SERT methylation level, while downregulation of lncRNA XIST reversed these effects. Serotonin 162-166 inactive X specific transcripts Mus musculus 22-26 32446903-12 2020 In conclusion, the key findings from our study indicated that lncRNA XIST acts as a regulator in 5-HT-induced visceral hypersensitivity in mice with IBS-D, providing a new insight into the regulatory effect of lncRNA XIST and its epigenetic diagnostic and therapeutic properties in IBS-D. Serotonin 97-101 inactive X specific transcripts Mus musculus 69-73 32446903-12 2020 In conclusion, the key findings from our study indicated that lncRNA XIST acts as a regulator in 5-HT-induced visceral hypersensitivity in mice with IBS-D, providing a new insight into the regulatory effect of lncRNA XIST and its epigenetic diagnostic and therapeutic properties in IBS-D. Serotonin 97-101 inactive X specific transcripts Mus musculus 217-221 17447416-1 2006 Monoamine oxidases A and B (MAO A and MAO B) are the major enzymes that catalyze the oxidative deamination of monoamine neurotaransmitters such as dopamine (DA), noradrenaline, and serotonin in the central and peripheral nervous systems. Serotonin 181-190 monoamine oxidase A Homo sapiens 28-43 2491757-0 1989 Effect of age on brain cortical protein kinase C and its mediation of 5-hydroxytryptamine release. Serotonin 70-89 protein kinase C, gamma Rattus norvegicus 32-48 16185722-5 2006 Expression of egr-1 in the CeA and lateral nucleus of the amygdala following administration of anxiolytic and anxiogenic benzodiazepine and serotonin agonists and antagonists was investigated. Serotonin 140-149 early growth response 1 Homo sapiens 14-19 2491757-1 1989 The effects of age on the activity and translocation of protein kinase C (PKC) and on the facilitation of 5-hydroxytryptamine (5-HT, serotonin) release induced by PKC activation with the phorbol ester phorbol 12-myristate 13-acetate were investigated. Serotonin 106-125 protein kinase C, gamma Rattus norvegicus 163-166 32711172-1 2020 TPH2, the rate-limiting enzyme in the synthesis of serotonin, has been connected to several psychiatric outcomes. Serotonin 51-60 tryptophan hydroxylase 2 Homo sapiens 0-4 32437889-9 2020 Bilateral VH infusion of Ang (1-7) recovered NMDAR-nNOS-NO signaling and MAO-mediated serotonin metabolism, as well as reducing anxiety-like behaviors in stressed rats. Serotonin 86-95 angiogenin Rattus norvegicus 25-33 2547173-3 1989 Contrastively, exogenous 5-HT and the selective 5-HT1B agonist 1-(m-chlorophenyl) piperazine HCl (mCPP) produced a dose-dependent increase in depolarization-evoked 3H-5-HT release from spinal cord of aged rats. Serotonin 25-29 5-hydroxytryptamine receptor 1B Rattus norvegicus 48-54 16330560-2 2005 2"-Methoxyphenyl-(N-2"-pyridinyl)-p-18F-fluoro-benzamidoethylpiperazine (18F-MPPF) is a specific serotonin 5-HT1A antagonist PET tracer recently characterized, modeled, and used for clinical research to explore abnormalities in the serotoninergic system. Serotonin 97-106 5-hydroxytryptamine receptor 1A Homo sapiens 107-113 2622533-3 1989 While dopaminergic neurons of the substantia nigra revealed no staining for monoamine oxidase, noradrenergic neurons of the locus coeruleus stained positively with the monoamine oxidase-A substrate serotonin, and serotonergic neurons of the raphe nuclei were stained by the monoamine oxidase-B substrate beta-phenylethylamine. Serotonin 198-207 monoamine oxidase B Homo sapiens 274-293 2567038-5 1989 The 5-HT1B or the 5-HT1D receptors play a role in the "defensive burying" anxiety model and probably mediate antidepressant and antianxiety effects of serotonin-uptake inhibitors. Serotonin 151-160 5-hydroxytryptamine receptor 1D Homo sapiens 18-24 32641996-0 2020 Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. Serotonin 32-41 tryptophan hydroxylase 1 Rattus norvegicus 114-118 32615731-0 2020 Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 67-88 16157418-1 2005 The main objective of this investigation was to test the hypothesis that brain serotonin (5-HT) synthesis, as measured by trapping of alpha-[(11)C]methyl-L-tryptophan (alpha-MTrp) using positron emission tomography (PET), can be modulated by changes in blood oxygen. Serotonin 79-88 lysosomal protein transmembrane 4 alpha Homo sapiens 174-178 15944205-6 2005 Six tryptophan metabolites, including the bioactive substances KYNA, XA, and the serotonin metabolite 5-hydroxyindol acetate inhibited [(3)H]p-aminohippurate (PAH) or 6-carboxyfluorescein (6-CF) uptake by 50-85%, demonstrating that these compounds interact with OAT1 as well as with OAT3. Serotonin 81-90 solute carrier family 22 (organic anion transporter), member 8 Mus musculus 283-287 3196741-3 1988 PAF was quantified by bioassay, its ability to cause [3H]serotonin release from washed rabbit platelets. Serotonin 57-66 PCNA clamp associated factor Rattus norvegicus 0-3 15951403-0 2005 Differential effects of the 5-hydroxytryptamine (5-HT)1A receptor inverse agonists Rec 27/0224 and Rec 27/0074 on electrophysiological responses to 5-HT1A receptor activation in rat dorsal raphe nucleus and hippocampus in vitro. Serotonin 28-47 5-hydroxytryptamine receptor 1A Homo sapiens 148-163 2459224-3 1988 PC1-F initiates PC1 CS by mediating an early 2-h skin swelling reaction that is due to local release of the vasoactive amine serotonin (5-HT) by mast cells, and perhaps other 5-HT-containing cells. Serotonin 125-134 minisatellite 6 hypermutable Mus musculus 0-3 15908219-2 2005 Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin. Serotonin 188-197 monoamine oxidase A Homo sapiens 172-177 2459224-3 1988 PC1-F initiates PC1 CS by mediating an early 2-h skin swelling reaction that is due to local release of the vasoactive amine serotonin (5-HT) by mast cells, and perhaps other 5-HT-containing cells. Serotonin 125-134 minisatellite 6 hypermutable Mus musculus 16-19 2843570-6 1988 beta-EP, alpha-MSH, and CLIP also inhibited 5HT-induced iCRH secretion. Serotonin 44-47 proopiomelanocortin Rattus norvegicus 9-18 3399126-0 1988 Visualization of a novel serotonin recognition site (5-HT1D) in the human brain by autoradiography. Serotonin 25-34 5-hydroxytryptamine receptor 1D Homo sapiens 53-59 15766329-0 2005 Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Serotonin 167-186 vimentin Homo sapiens 45-53 3399126-1 1988 The localization of a novel serotonin (5-hydroxytryptamine, 5-HT) recognition site named 5-HT1D was studied by autoradiography in human postmortem brain material. Serotonin 28-37 5-hydroxytryptamine receptor 1D Homo sapiens 89-95 3399126-1 1988 The localization of a novel serotonin (5-hydroxytryptamine, 5-HT) recognition site named 5-HT1D was studied by autoradiography in human postmortem brain material. Serotonin 39-58 5-hydroxytryptamine receptor 1D Homo sapiens 89-95 3283237-10 1988 Human C3a, but not C3a des Arg induces serotonin release and aggregation of the guinea pig platelets. Serotonin 39-48 complement C3 Homo sapiens 6-9 15766329-0 2005 Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Serotonin 167-186 vimentin Homo sapiens 105-113 15766329-3 2005 Vimentin filaments became straight and were arranged along the long axis of cells upon stimulation with 5-hydroxytryptamine (5-HT; serotonin). Serotonin 104-123 vimentin Homo sapiens 0-8 15766329-3 2005 Vimentin filaments became straight and were arranged along the long axis of cells upon stimulation with 5-hydroxytryptamine (5-HT; serotonin). Serotonin 131-140 vimentin Homo sapiens 0-8 3402898-0 1988 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Serotonin 0-19 5-hydroxytryptamine receptor 1B Rattus norvegicus 165-171 3402898-0 1988 5-Hydroxytryptamine stimulates two distinct adenylate cyclase activities in rat brain: high-affinity activation is related to a 5-HT1 subtype different from 5-HT1A, 5-HT1B, and 5-HT1C. Serotonin 0-19 5-hydroxytryptamine receptor 2C Rattus norvegicus 177-183 15944377-2 2005 Here we show that serotonin, by activating 5-HT(1A) receptors, inhibited NMDA receptor-mediated ionic and synaptic currents in PFC pyramidal neurons, and the NR2B subunit-containing NMDA receptor is the primary target of 5-HT(1A) receptors. Serotonin 18-27 5-hydroxytryptamine receptor 1A Homo sapiens 43-50 2456276-1 1988 The platelet-activating factor (PAF) has been shown to stimulate the release of prostaglandins, leukotrienes and 5HT from a number of cell types. Serotonin 113-116 PCNA clamp associated factor Rattus norvegicus 32-35 15944377-2 2005 Here we show that serotonin, by activating 5-HT(1A) receptors, inhibited NMDA receptor-mediated ionic and synaptic currents in PFC pyramidal neurons, and the NR2B subunit-containing NMDA receptor is the primary target of 5-HT(1A) receptors. Serotonin 18-27 5-hydroxytryptamine receptor 1A Homo sapiens 221-228 15944377-8 2005 The 5-HT(1A)-NMDAR interaction provides a potential mechanism underlying the role of serotonin in controlling emotional and cognitive processes subserved by PFC. Serotonin 85-94 5-hydroxytryptamine receptor 1A Homo sapiens 4-11 15916420-2 2005 Novel binding profiles of ferrocenylcarboxamides combining subnanomolar Ki values for the dopamine D4 receptor (1a, 0.52 nM; 1b, 0.63 nM) with superpotent serotonin 5-hydroxytryptamine1A (1a, 0.50 nM) and dopamine D3 receptor binding (1b, 0.64 nM) and selective D4 agonist properties of the ruthenocene 1c may be a starting point for highly beneficial central nervous system active drugs. Serotonin 155-164 dopamine receptor D4 Homo sapiens 90-110 3339401-1 1988 The actions of 5-hydroxytryptamine (5-HT) and buspirone, an anxiolytic agent that displays high and selective affinity for 5-HT1A receptor sites, on synaptic activation of hippocampal CA1 pyramidal cells were studied in vitro. Serotonin 15-34 carbonic anhydrase 1 Homo sapiens 184-187 15869768-6 2005 In specific, recent studies using PET with serotonin specific radioligands implicate alterations of 5-HT1A and 5-HT2A receptors and the 5-HT transporter. Serotonin 43-52 5-hydroxytryptamine receptor 1A Homo sapiens 100-112 3172981-2 1988 In contrast, serotonin (5-HT) agonists with 5-HT1A site specificity (8-OH-DPAT, buspirone) as well as trazodone, ritanserin, and metergoline were no different from saline in producing penile erections. Serotonin 13-22 5-hydroxytryptamine receptor 1A Macaca mulatta 44-50 15862800-0 2005 Molecular and pharmacological characterization of serotonin 5-HT2A and 5-HT2B receptor subtypes in dog. Serotonin 50-59 5-hydroxytryptamine receptor 2A Canis lupus familiaris 60-66 3694251-2 1987 The effect of serotonin (5-HT) and forskolin on a hyperpolarization activated Cl- conductance (gCl-) was studied using voltage-clamp techniques in identified Aplysia neurons maintained in primary cell culture. Serotonin 14-23 germ cell-less 2, spermatogenesis associated Homo sapiens 95-98 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Serotonin 90-99 monoamine oxidase A Homo sapiens 0-26 2890079-5 1987 Then the effect of a spike concentration of SRIF or GH on hepatic portal and peripheral levels of free serotonin and catecholamines was studied, all by radioenzymatic methods. Serotonin 103-112 somatotropin Canis lupus familiaris 52-54 2890079-6 1987 The intravenous injection of ovine GH (100 micrograms/kg) or equimolar amounts of SRIF (7.5 micrograms/kg) produced in the hepatic portal circulation a transient but statistically significant rise of serotonin and a concomitant reduction in the concentration of dopamine, norepinephrine, and epinephrine. Serotonin 200-209 somatotropin Canis lupus familiaris 35-37 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Serotonin 90-99 monoamine oxidase A Homo sapiens 28-33 3668856-2 1987 The present study was designed to explore the possibility that 5HT-induced contractions in the rat stomach fundus were mediated by interaction with receptors identical with either 5HT1A, 5HT1B or 5HT1C binding sites or 5HT3 receptors. Serotonin 63-66 5-hydroxytryptamine receptor 1B Rattus norvegicus 187-192 15634690-7 2005 Consistently brain neurochemical assays show that both dopamine and serotonin are significantly increased in dfmr1 null mutants. Serotonin 68-77 Fmr1 Drosophila melanogaster 109-114 3668856-2 1987 The present study was designed to explore the possibility that 5HT-induced contractions in the rat stomach fundus were mediated by interaction with receptors identical with either 5HT1A, 5HT1B or 5HT1C binding sites or 5HT3 receptors. Serotonin 63-66 5-hydroxytryptamine receptor 2C Rattus norvegicus 196-201 3600775-0 1987 Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin. Serotonin 87-96 carbonic anhydrase 1 Homo sapiens 72-75 2435172-3 1987 We explored the possibility that CCK-mediated contractions in the guinea pig colon occur via a serotonin and/or substance P pathway. Serotonin 95-104 cholecystokinin Cavia porcellus 33-36 2435172-8 1987 Desensitization to serotonin antagonized the action of CCK-8 but had no effect on substance P-mediated contractions. Serotonin 19-28 cholecystokinin Cavia porcellus 55-60 15655527-0 2005 Voltage-dependent inhibition of recombinant NMDA receptor-mediated currents by 5-hydroxytryptamine. Serotonin 79-98 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 44-57 2435172-9 1987 Pretreatment with the serotonin antagonist mianserin inhibited CCK-8- but not substance P-generated contractions. Serotonin 22-31 cholecystokinin Cavia porcellus 63-68 2435172-12 1987 In contrast, CCK-8 generated contractions in guinea pig colon longitudinal layer, mediated by a pathway involving serotonin and substance P. Serotonin 114-123 cholecystokinin Cavia porcellus 13-18 3817298-1 1987 Two types of monoamine oxidase activity (MAO-A and MAO-B) help regulate the levels of biogenic amines such as catecholamines and serotonin. Serotonin 129-138 monoamine oxidase B Rattus norvegicus 51-56 15654302-1 2005 BACKGROUND: We reported previously that a moderate level of fetal alcohol treatment reduces the birth, maturation, and migration of serotonin (5-HT) neurons at embryonic days 11 to 15 (E11-E15). Serotonin 132-141 RNA, U105C small nucleolar Homo sapiens 189-192 3019887-2 1986 Norepinephrine, epinephrine, and phenylephrine stimulated tonin release, an effect that was inhibited by phentolamine but not by propranolol, whereas isoproterenol, carbachol, histamine, and serotonin did not stimulate tonin release. Serotonin 191-200 kallikrein 1-related peptidase C2 Rattus norvegicus 58-63 15813642-5 2005 In addition, the SP/NK1R system shows significant spatial overlap with neurotransmitters such as serotonin and noradrenaline (norepinephrine), which are known to be involved in the regulation of stress, mood and anxiety. Serotonin 97-106 tachykinin receptor 1 Homo sapiens 20-24 15663479-7 2005 The differences between TPH1 and TPH2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for TPH from different sources in the past. Serotonin 88-97 tryptophan hydroxylase 1 Homo sapiens 24-28 3763057-2 1986 The mammalian choroid plexus is enriched in a newly described serotonin recognition site, the 5-HT1C site. Serotonin 62-71 5-hydroxytryptamine receptor 2C Homo sapiens 94-100 3742199-1 1986 Tryptophan hydroxylase (TPH) is the rate limiting enzyme in serotonin biosynthesis, so its development is very important to the functional maturation of the serotonergic neurons. Serotonin 60-69 tryptophan hydroxylase 1 Rattus norvegicus 0-22 16080341-8 2005 In the neocortex of animals that developed during the serotonin depletion, GFAP-positive cells were formed in decreased numbers, in particular, in the white matter, at all the stages of postnatal development studied. Serotonin 54-63 glial fibrillary acidic protein Mus musculus 75-79 3742199-1 1986 Tryptophan hydroxylase (TPH) is the rate limiting enzyme in serotonin biosynthesis, so its development is very important to the functional maturation of the serotonergic neurons. Serotonin 60-69 tryptophan hydroxylase 1 Rattus norvegicus 24-27 3705019-2 1986 When rabbit platelets were stimulated with 0.1 U/ml thrombin, they changed their shape, secreted serotonin, and incorporated actin-binding protein (ABP), myosin, and actin into their cytoskeletons. Serotonin 97-106 prothrombin Oryctolagus cuniculus 52-60 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Serotonin 94-103 monoamine oxidase A Homo sapiens 0-19 3705019-3 1986 Platelets treated with 2 microM cytochalasin E and stimulated with 0.1 U/ml thrombin secreted serotonin and assembled myosin and actin into their cytoskeletons, but did not change in shape. Serotonin 94-103 prothrombin Oryctolagus cuniculus 76-84 15990460-1 2005 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. Serotonin 94-103 monoamine oxidase A Homo sapiens 21-25 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Serotonin 131-140 monoamine oxidase A Homo sapiens 0-19 2432823-3 1986 Evidence indicates that results obtained proportionately reflect changes of 5HT metabolism in whole brain (CSF method) and in the striatum (intracerebral dialysis). Serotonin 76-79 colony stimulating factor 2 Rattus norvegicus 107-110 2432823-5 1986 The first suggested that 5HT turnover values (determined two weeks prior to behavioral testing by the CSF method) were predictive for neck + body biting in a social interaction test. Serotonin 25-28 colony stimulating factor 2 Rattus norvegicus 102-105 32314850-8 2020 Acetyl-CoA is a necessary cosubstrate for arylalkylamine N-acetyltransferase, providing an acetyl group to serotonin, and thereby initiating the melatonergic pathway. Serotonin 107-116 aralkylamine N-acetyltransferase Homo sapiens 42-76 16110245-1 2005 Monoamine oxidase A (MAOA), a mitochondrial outer membrane enzyme, degrades biogenic amines including norepinephrine, dopamine and serotonin, which have been implicated in the expression of personality traits. Serotonin 131-140 monoamine oxidase A Homo sapiens 21-25 3632910-1 1986 The effect of 0.01 U/ml of kallikrein on serotonin and bradykinin contractile action in the isolated intestinal segment has been described. Serotonin 41-50 kallikrein related peptidase 4 Homo sapiens 27-37 3632910-4 1986 Kallikrein is supposed to serve as a modulator of intestinal serotonin- and bradykininergic myotropic reactions. Serotonin 61-70 kallikrein related peptidase 4 Homo sapiens 0-10 15780474-16 2005 Thus, all serotonin-related mRNAs examined in the dorsal raphe to date were lower (SERT, MAO-A) or exhibited a lower trend (5HT1A, MAO-B) in the stress sensitive animals, which probably reflects the lower number of serotonin neurons present. Serotonin 10-19 sodium-dependent serotonin transporter Macaca fascicularis 83-87 32410942-6 2020 Neurochemical tests showed lower dopamine concentrations in specific brain regions of VMAT2DATcre-HET mice, especially the ventral tegmental area/substantia nigra and striatum, together with relatively unchanging concentrations of norepinephrine and serotonin, demonstrating the dopaminergic specificity of this mouse model. Serotonin 250-259 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 86-91 15589338-0 2004 Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression. Serotonin 35-44 brain derived neurotrophic factor Mus musculus 49-82 20493117-5 1986 This hyperdensity in 5HT1B sites in the SNR likely explains the functional hypersensitivity previously demonstrated by local injection of exogenous 5HT into the SN and systemic administration of RU 24969, a preferential 5HT1B agonist. Serotonin 21-24 5-hydroxytryptamine receptor 1B Rattus norvegicus 220-225 15589338-1 2004 Serotonin (5-HT) has been proposed to promote neuronal plasticity during the treatment of mood and anxiety disorders and following neurodegenerative insult by altering the expression of critical genes including brain-derived neurotrophic factor (BDNF). Serotonin 0-9 brain derived neurotrophic factor Mus musculus 211-244 15589338-1 2004 Serotonin (5-HT) has been proposed to promote neuronal plasticity during the treatment of mood and anxiety disorders and following neurodegenerative insult by altering the expression of critical genes including brain-derived neurotrophic factor (BDNF). Serotonin 0-9 brain derived neurotrophic factor Mus musculus 246-250 32327735-8 2021 Here we showed that n-3 PUFAs and escitalopram (selective serotonin reuptake inhibitors, SSRIs) treatment increased adenylyl cyclase (AC) and BDNF gene expression in LCLs. Serotonin 58-67 brain derived neurotrophic factor Homo sapiens 142-146 3903555-3 1985 Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc. Serotonin 106-125 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 9-11 15572052-1 2004 Serotonin (5-hydroxytryptamine [5-HT]), which induces vasoconstriction via 5-HT2A receptors in smooth muscle cells and vasodilation through activating nitric oxide (NO) synthase (NOS) via 5-HT1B receptors in endothelial cells, possesses divergent effects on regulating vascular tone. Serotonin 0-9 5-hydroxytryptamine receptor 2A Canis lupus familiaris 75-81 2862637-6 1985 Thus, the effects of spike concentrations of GH on plasma serotonin and catecholamines are apparently mediated by SRIF, a novel and unexpected function for a hormone that is known as an inhibitor of GH secretion. Serotonin 58-67 somatotropin Canis lupus familiaris 45-47 32368008-7 2020 Studies have suggested that GAL enhances the action of selective serotonin reuptake inhibitors (SSRIs) and promotes availability of transcription proteins. Serotonin 65-74 galanin and GMAP prepropeptide Homo sapiens 28-31 15572052-1 2004 Serotonin (5-hydroxytryptamine [5-HT]), which induces vasoconstriction via 5-HT2A receptors in smooth muscle cells and vasodilation through activating nitric oxide (NO) synthase (NOS) via 5-HT1B receptors in endothelial cells, possesses divergent effects on regulating vascular tone. Serotonin 11-30 5-hydroxytryptamine receptor 2A Canis lupus familiaris 75-81 15574139-11 2004 5-HTRA inhibited vasoconstriction and the reduction of blood flow in chronically compressed nerve roots challenged with serotonin. Serotonin 120-129 HtrA serine peptidase 1 Homo sapiens 2-6 31746551-2 2020 Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. Serotonin 41-50 brain derived neurotrophic factor Homo sapiens 109-113 2995061-2 1985 A first series of experiments served to assess the responsiveness of CA3 hippocampal pyramidal neurons to microiontophoretically applied serotonin (5-HT) and norepinephrine (NE). Serotonin 137-146 carbonic anhydrase 3 Rattus norvegicus 69-72 4041988-1 1985 The effects of a spike concentration of growth hormone (GH) on hepatic portal and peripheral levels of free serotonin and catecholamines were studied by improved radioenzymatic methods in trained, conscious, normal, adult dogs fitted with an indwelling portal catheter. Serotonin 108-117 somatotropin Canis lupus familiaris 40-54 4041988-1 1985 The effects of a spike concentration of growth hormone (GH) on hepatic portal and peripheral levels of free serotonin and catecholamines were studied by improved radioenzymatic methods in trained, conscious, normal, adult dogs fitted with an indwelling portal catheter. Serotonin 108-117 somatotropin Canis lupus familiaris 56-58 4041988-2 1985 An injection of ovine GH (6 or 100 micrograms/kg) into a cephalic vein produced in the hepatic portal circulation a transient, statistically significant rise of serotonin and a concomitant significant reduction in the concentration of dopamine, norepinephrine, and epinephrine. Serotonin 161-170 somatotropin Canis lupus familiaris 22-24 15574139-12 2004 This fact suggests that 5-HTRA might be effective at improving blood flow in chronically compressed nerve roots in patients with spinal canal stenosis and changes in circulation levels of serotonin. Serotonin 188-197 HtrA serine peptidase 1 Homo sapiens 26-30 32041793-6 2020 Importantly, serotonin signaling through 5-HT4 mimicked the effects of L3740, acting downstream of GLP-1. Serotonin 13-22 5-hydroxytryptamine receptor 4 Homo sapiens 41-46 15448143-7 2004 When expressed in Madin-Darby canine kidney cells and Xenopus laevis oocytes, PMAT efficiently transports serotonin (K(m) = 114 mum), dopamine (K(m) = 329 mum), and the neurotoxin 1-methyl-4-phenylpyridinium (K(m) = 33 mum). Serotonin 106-115 solute carrier family 29 member 4 Homo sapiens 78-82 6427633-6 1984 In addition, 5HT caused a concentration-dependent rise of intracellular free Ca2+ in platelets which was counteracted by ketanserin. Serotonin 13-16 carbonic anhydrase 2 Homo sapiens 77-80 15467993-4 2004 Although the exact role of serotonergic neurotransmission in PFC remains largely unknown, the PFC contains a very large density or serotonin 5-HT1A (inhibitory) and 5-HT2A (excitatory) receptors. Serotonin 131-140 5-hydroxytryptamine receptor 1A Homo sapiens 141-147 6145355-4 1984 Serotonin stimulates cell motility, protein carboxyl methylation, and cyclic GMP. Serotonin 0-9 5'-nucleotidase, cytosolic II Homo sapiens 77-80 31897573-4 2020 Given that the serotonin 5-HT2C receptor and histaminergic H1 receptor are involved in aspects of feeding behaviour, the effect of clozapine on feeding may be linked to its action at these receptors. Serotonin 15-24 5-hydroxytryptamine receptor 2C Rattus norvegicus 25-31 15152026-1 2004 The serotonin (5-hydroxytryptamine1A) 5-HT1A receptor agonist 8-OH-DPAT [(R)- (+)-8-hydroxy-2-(di-n-propylamino)tetralin] inhibits bladder activity under nociceptive but not innocuous conditions in cats with an intact spinal cord, suggestive of an effect on primary afferent C fibers or their targets. Serotonin 4-13 5-hydroxytryptamine receptor 1A Homo sapiens 38-44 6200170-1 1984 The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. Serotonin 179-198 somatostatin Homo sapiens 40-52 6200170-1 1984 The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. Serotonin 179-198 gastrin releasing peptide Homo sapiens 58-66 15272208-1 2004 We previously demonstrated that repeated electroconvulsive shock (ECS) treatment enhanced serotonin (5-HT)(1A)- and 5-HT(3)-receptor-mediated responses in hippocampal CA1 pyramidal neurons. Serotonin 90-99 carbonic anhydrase 1 Rattus norvegicus 167-170 6295549-0 1982 Effects of norepinephrine and serotonin upon spontaneous activity and responses to mossy fiber stimulation of CA3 neurons in hippocampal slices. Serotonin 30-39 carbonic anhydrase 3 Rattus norvegicus 110-113 31959933-4 2020 Here we report that serotonin 2c receptor (Htr2c)-expressing neurons in the lateral parabrachial nucleus (LPBNHtr2c neurons) inhibit sodium appetite. Serotonin 20-29 5-hydroxytryptamine receptor 2C Homo sapiens 43-48 31959933-4 2020 Here we report that serotonin 2c receptor (Htr2c)-expressing neurons in the lateral parabrachial nucleus (LPBNHtr2c neurons) inhibit sodium appetite. Serotonin 20-29 5-hydroxytryptamine receptor 2C Homo sapiens 106-115 6890383-6 1982 (4) Verapamil, tetracaine and lanthanum inhibited thrombin-induced release of serotonin. Serotonin 78-87 prothrombin Oryctolagus cuniculus 50-58 15084420-0 2004 Serotonin modifies corticotropin-releasing factor-induced behaviors of chicks. Serotonin 0-9 corticotropin releasing hormone Homo sapiens 19-49 6890383-9 1982 It is concluded that the serotonin release induced by some calcium blockers and the inhibition of the thrombin-induced release by the same drugs are two separate phenomena. Serotonin 25-34 prothrombin Oryctolagus cuniculus 102-110 6281503-0 1982 Effect of cholecystokinin on thyrotropin releasing hormone (TRH)-induced serotonin potentiation in rats. Serotonin 73-82 cholecystokinin Rattus norvegicus 10-25 32078638-6 2020 Pharmacological studies revealed that enhanced depressive-like behavior in GluD1-KO mice was restored by the serotonin reuptake inhibitors imipramine and fluoxetine, but not the norepinephrine transporter inhibitor desipramine. Serotonin 109-118 glutamate dehydrogenase 1 Mus musculus 75-80 7111338-2 1982 In addition to norepinephrine, serotonin and gamma-aminobutyric acid (GABA) seem to modulate NAT activity. Serotonin 31-40 bromodomain containing 2 Homo sapiens 93-96 15166637-7 2004 In nonalcoholic suicides, there is a localized increase in 5-HT1A binding in ventral prefrontal cortex, hypothesized to be a response to less serotonin input. Serotonin 142-151 5-hydroxytryptamine receptor 1A Homo sapiens 59-65 7274094-3 1981 Since TPH is thought to be rate-limiting for serotonin (5-HT) synthesis in the developing animal as well as in the adult altered TPH activity as a result of maternal influences could change 5-HT synthesis in the embryo. Serotonin 45-54 tryptophan hydroxylase 1 Rattus norvegicus 6-9 31819986-0 2020 Association Between Side Effects and Blood microRNA Expression Levels and Their Targeted Pathways in Patients With Major Depressive Disorder Treated by a Selective Serotonin Reuptake Inhibitor, Escitalopram: A CAN-BIND-1 Report. Serotonin 164-173 3-hydroxyacyl-CoA dehydratase 3 Homo sapiens 214-220 31801810-6 2020 The expression ratios of 5-HT3A receptors and p11, a serotonin receptor-interacting protein, were higher in PSA-NCAM+/CCK+ cells than in PSA-NCAM-/CCK+ cells. Serotonin 53-62 cholecystokinin Mus musculus 118-121 31940833-4 2020 Under the optimized conditions, the analytical performance demonstrated a convenient degree of sensitivity: 0.0369 and 0.0256 muA mM-1 cm-2, selectivity in a broad linear range (0.1-200) x 10-6 M) with detection limits of 48 and 73 nM (for the serotonin and dopamine biosensors, respectively). Serotonin 246-255 Mix1 homeobox-like 1 (Xenopus laevis) Mus musculus 130-139 14985263-2 2004 Experimental data in animals show that 5-HT1A receptors are predominantly located in limbic areas, and that serotonin, via these receptors, mediates an antiepileptic and anticonvulsant effect. Serotonin 108-117 5-hydroxytryptamine receptor 1A Homo sapiens 39-45 32148370-1 2019 Context: Polymorphism on tryptophan hydroxylase 2 (TPH2) gene rs120074175 can cause the synthesis of neurotransmitter serotonin in the brain to reduce up to 80%. Serotonin 118-127 tryptophan hydroxylase 2 Homo sapiens 25-49 32148370-1 2019 Context: Polymorphism on tryptophan hydroxylase 2 (TPH2) gene rs120074175 can cause the synthesis of neurotransmitter serotonin in the brain to reduce up to 80%. Serotonin 118-127 tryptophan hydroxylase 2 Homo sapiens 51-55 106542-1 1979 Effects of biogenic amines--noradrenaline and serotonin--on phosphorylase, acid alpha-glucosidase (gamma-amilase), glycogen synthetase as well as on content of glycogen in rat liver tissue, heart and skeletal muscles were studied in vivo. Serotonin 46-55 alpha glucosidase Rattus norvegicus 75-97 15030389-0 2004 Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. Serotonin 72-81 tachykinin 1 Mus musculus 12-23 694207-1 1978 The effect of serotonin (10 mg/kg weight) on the gastrin serum levels in rats has been studied. Serotonin 14-23 gastrin Rattus norvegicus 49-56 31184239-14 2019 Expression of tryptophan hydroxylase 2 mRNA and protein, which catalyses serotonin synthesis, as well as numbers of serotonin-immunoreactive neurons, were decreased in the brainstem raphe nuclei. Serotonin 73-82 tryptophan hydroxylase 2 Rattus norvegicus 14-38 15030389-0 2004 Blockade of substance P (neurokinin 1) receptors enhances extracellular serotonin when combined with a selective serotonin reuptake inhibitor: an in vivo microdialysis study in mice. Serotonin 72-81 tachykinin 1 Mus musculus 25-37 31472147-6 2019 KEY FINDINGS: First, cultured human ovary cumulus cells synthesized melatonin in vitro, and it expressed serotonin (the precursor of melatonin) and the two key enzymes, i.e. N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 105-114 bromodomain containing 2 Homo sapiens 174-193 14755456-1 2004 Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Serotonin 251-260 monoamine oxidase A Homo sapiens 0-19 31261385-1 2019 Pyridox (am) ine 5"-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (VB6) to pyridoxal 5"-phosphate (PLP), the biologically active form of VB6 and involved in the synthesis of neurotransmitters including gamma-aminobutyric acid (GABA), dopamine, and serotonin. Serotonin 286-295 pyridoxamine 5'-phosphate oxidase Homo sapiens 39-43 30959513-3 2019 We hypothesize that 5-HT acts as an endogenous modulator of the central GLP-1 system to mediate satiation and malaise in rats. Serotonin 20-24 glucagon Rattus norvegicus 72-77 30959513-5 2019 Results show that the anorexia and body weight changes induced by administration of exogenous hindbrain 5-HT are dependent on central GLP-1 receptor signaling. Serotonin 104-108 glucagon-like peptide 1 receptor Rattus norvegicus 134-148 30959513-9 2019 Our findings highlight 5-HT as a novel endogenous modulator of the central GLP-1 system and suggest that the central interaction between 5-HT and GLP-1 is involved in the control of food intake in rats. Serotonin 23-27 glucagon Rattus norvegicus 75-80 80935-4 1978 Receptor interaction studies of MBP with H3-labelled 5-hydroxytryptamine and naloxone gave negative results. Serotonin 53-72 myelin basic protein Rattus norvegicus 32-35 734357-1 1978 3H-serotonin release from guinea-pig platelets was demonstrated to be the consequence of C3a binding to these cells. Serotonin 3-12 complement C3 Homo sapiens 89-92 734357-5 1978 The release of serotonin may be induced by a combined reaction of C3a with HA receptors and LA receptors on the platelet membrane. Serotonin 15-24 complement C3 Homo sapiens 66-69 14755456-1 2004 Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Serotonin 251-260 monoamine oxidase A Homo sapiens 21-25 14684242-0 2004 Alpha-lactalbumin-enriched diets enhance serotonin release and induce anxiolytic and rewarding effects in the rat. Serotonin 41-50 lactalbumin, alpha Rattus norvegicus 0-17 305702-1 1978 In experiments on rabbits a study was made of the influence of serotonin"s precursor, 5-oxytriptophane (5-OTP), on trace processes in spike activity of neurones in the visual and sensorimotor cortical areas. Serotonin 63-72 homeobox protein orthopedia Oryctolagus cuniculus 106-109 1087792-1 1976 As a result of intravenous administration of 100 mg/kg of 5-oxytryptophane (5-OTP) to mice, the serotonin content in the brain rises in ten minutes by 35 to 37 per cent, and in an hour, by 58 to 60 per cent, and declines in a day to its initial level. Serotonin 96-105 orthopedia homeobox Mus musculus 78-81 31216440-0 2019 Chemerin influences endothelin- and serotonin-induced pulmonary artery vasoconstriction in rats. Serotonin 36-45 retinoic acid receptor responder 2 Rattus norvegicus 0-8 31216440-8 2019 Chemerin potentiated phenylephrine-, endothelin-1- and serotonin-induced vasoconstriction, which was further enhanced by endothelium removal. Serotonin 55-64 retinoic acid receptor responder 2 Rattus norvegicus 0-8 14684242-2 2004 Consequently, contrary to casein (CAS), LAC ingestion increases Trp access to the brain leading to enhanced serotonin (5-HT) synthesis. Serotonin 108-117 lactalbumin, alpha Rattus norvegicus 40-43 31216212-1 2019 Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Serotonin 82-91 tryptophan hydroxylase 2 Homo sapiens 14-38 14719046-3 2004 In addition, the enzyme indoleamine 2,3-dioxygenase (IDO), which converts tryptophan into kynurenine, may play an important role, first, because IDO activation leads to reduced levels of tryptophan, the precursor of serotonin (5-HT), and thus to reduced central 5-HT synthesis. Serotonin 216-225 indoleamine 2,3-dioxygenase 1 Homo sapiens 24-51 31216212-1 2019 Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Serotonin 82-91 tryptophan hydroxylase 2 Homo sapiens 40-44 31216212-1 2019 Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Serotonin 93-97 tryptophan hydroxylase 2 Homo sapiens 14-38 31216212-1 2019 Introduction: Tryptophan hydroxylase 2 (TPH2) is the key, rate-limiting enzyme of serotonin (5-HT) synthesis in the brain. Serotonin 93-97 tryptophan hydroxylase 2 Homo sapiens 40-44 31072928-0 2019 Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2A receptor and SIRT1-PGC-1alpha axis. Serotonin 0-9 sirtuin 1 Homo sapiens 113-118 31072928-3 2019 Here, we identify an important role for serotonin (5-HT) as a regulator of mitochondrial biogenesis and function in rodent cortical neurons, via a 5-HT2A receptor-mediated recruitment of the SIRT1-PGC-1alpha axis, which is relevant to the neuroprotective action of 5-HT. Serotonin 40-49 sirtuin 1 Homo sapiens 191-196 819038-9 1976 Thrombin produces an immediate release of platelet calcium and labeled serotonin and an increase in the 45Ca2+ uptake of both the surface and internal compartments. Serotonin 71-80 coagulation factor II, thrombin Bos taurus 0-8 24271344-3 1976 We found that PDEA can be released from brain particulate fraction by 1 muM norepinephrine, dopamine, adenosine, and histamine in the presence of ATP and a purified cAMP-dependent protein kinase; in similar conditions, serotonin is ineffective in concentrations up to 0.1 mM. Serotonin 219-228 phosphodiesterase 6A Homo sapiens 14-18 31072928-3 2019 Here, we identify an important role for serotonin (5-HT) as a regulator of mitochondrial biogenesis and function in rodent cortical neurons, via a 5-HT2A receptor-mediated recruitment of the SIRT1-PGC-1alpha axis, which is relevant to the neuroprotective action of 5-HT. Serotonin 51-55 sirtuin 1 Homo sapiens 191-196 15489027-4 2004 Previous electrophysiological studies have shown that the 5-HT(4) agonist, Zacopride, can increase population spike amplitude recorded in region CA1 of rat hippocampal slices in a cyclic AMP (cAMP)/cAMP-dependent protein kinase A-dependent manner. Serotonin 58-62 carbonic anhydrase 1 Rattus norvegicus 145-148 31072928-3 2019 Here, we identify an important role for serotonin (5-HT) as a regulator of mitochondrial biogenesis and function in rodent cortical neurons, via a 5-HT2A receptor-mediated recruitment of the SIRT1-PGC-1alpha axis, which is relevant to the neuroprotective action of 5-HT. Serotonin 147-151 sirtuin 1 Homo sapiens 191-196 31072928-6 2019 Mechanistically, the effects of 5-HT were mediated via the 5-HT2A receptor and master modulators of mitochondrial biogenesis, SIRT1 and PGC-1alpha. Serotonin 32-36 sirtuin 1 Homo sapiens 126-131 31072928-7 2019 SIRT1 was required to mediate the effects of 5-HT on mitochondrial biogenesis and function in cortical neurons. Serotonin 45-49 sirtuin 1 Homo sapiens 0-5 785686-3 1976 After treatment with high concentrations of thrombin (0.5 units/ml) single platelets can be recovered that have lost practically all of their releasable serotonin and adenine nucleotides. Serotonin 153-162 prothrombin Oryctolagus cuniculus 44-52 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Serotonin 94-103 monoamine oxidase A Homo sapiens 0-19 933208-2 1976 Alpha-MSH increased the incorporation of tritiated trytophan into serotonin in the cortex and slightly decreased that of tryosine into the dopamine in the hypothalamus. Serotonin 66-75 proopiomelanocortin Rattus norvegicus 0-9 31072928-10 2019 In cortical neurons, 5-HT enhanced expression of antioxidant enzymes, decreased cellular reactive oxygen species, and exhibited neuroprotection against excitotoxic and oxidative stress, an effect that required SIRT1. Serotonin 21-25 sirtuin 1 Homo sapiens 210-215 15539858-2 2004 Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine. Serotonin 94-103 monoamine oxidase A Homo sapiens 21-25 14638386-7 2003 In percent of tissue-[3H], the 3,4-DAP-evoked overflow of [3H]serotonin was increased (+28%), and that of [3H]acetylcholine was reduced (-23%) in the aged rats. Serotonin 62-71 death-associated protein Rattus norvegicus 35-38 30735758-0 2019 Serotonin type 6 receptor antagonist attenuates the impairment of long-term potentiation and memory induced by Abeta. Serotonin 0-9 amyloid beta precursor protein Rattus norvegicus 111-116 810812-10 1975 TRH was also found active in potentiating the central effects of serotonin. Serotonin 65-74 thyrotropin releasing hormone Mus musculus 0-3 15073568-0 2003 In humans, corticotropin releasing hormone antagonizes some of the negative immunoregulatory effects of serotonin. Serotonin 104-113 corticotropin releasing hormone Homo sapiens 11-42 1168649-0 1975 Transport and storage of serotonin by thrombin-treated platelets. Serotonin 25-34 prothrombin Oryctolagus cuniculus 38-46 1168649-1 1975 Repeated thrombin treatment of washed platelets prepared from rabbits can decrease the serotonin content of the platelets by about 80%. Serotonin 87-96 prothrombin Oryctolagus cuniculus 9-17 30983508-1 2019 Aim: To examine the impact of CYP2C19 genotype on selective serotonin reuptake inhibitor (SSRI) prescribing patterns. Serotonin 60-69 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 30-37 14594742-2 2003 The purpose of this positron emission tomography (PET) study was to search for relationships between serotonin 5-HT(1A) receptor density and personality traits. Serotonin 101-110 5-hydroxytryptamine receptor 1A Homo sapiens 111-128 30661441-3 2019 Area covered: This paper concentrates on the interaction between 5-HT and BDNF systems and its implication in different plasticity levels, from neurons to behavior. Serotonin 65-69 brain derived neurotrophic factor Homo sapiens 74-78 30661441-5 2019 Expert opinion: Dysregulation in 5-HT-BDNF interaction may be responsible for development of neuropsychiatric and behavioral abnormalities. Serotonin 33-37 brain derived neurotrophic factor Homo sapiens 38-42 30661441-6 2019 5-HT-BDNF cross-talk is a potential target for the treatment of various neurological diseases. Serotonin 0-4 brain derived neurotrophic factor Homo sapiens 5-9 30661441-7 2019 Understanding the function of the members of BDNF system in response to challenges of the environment and the interaction with different 5-HT receptors in health and disease will one day lead to new classes of drugs. Serotonin 137-141 brain derived neurotrophic factor Homo sapiens 45-49 4537396-0 1972 New degradative routes of 5-hydroxytryptophan and serotonin by intestinal tryptophan 2,3-dioxygenase. Serotonin 50-59 tryptophan 2,3-dioxygenase Homo sapiens 74-100 5643059-6 1968 These data support a previous suggestion that inhibition of tryptophan pyrrolase in endotoxin-poisoned mice has the effect of funneling injected tryptophan into the serotonin pathway. Serotonin 165-174 tryptophan 2,3-dioxygenase Mus musculus 60-80 14519961-1 2003 We previously reported that a serotonin precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. Serotonin 30-39 leptin Mus musculus 94-100 13499722-0 1957 [Activity of an anti-serotonin molecule: 1-benzyl-2-methyl-5-methoxytryptamine (BAS) on several isolated organs and on diuresis]. Serotonin 21-30 BAS Homo sapiens 80-83 30904940-10 2019 5-MeO-AI exhibited some selectivity for SERT, having sixfold lower potency at NET and 20-fold lower potency at DAT. Serotonin 40-44 solute carrier family 6 member 3 Homo sapiens 111-114 30787865-2 2019 This association has been further strengthened by our discovery that integrin beta3-containing receptors (alphavbeta3) physically interact with, and thereby define, a subpopulation of SERTs that may represent the main target of selective serotonin reuptake inhibitors (SSRIs). Serotonin 238-247 integrin beta 3 Mus musculus 69-83 34052271-7 2021 ZA2G is related to tryptophan metabolism, which is a main serotonin synthesis pathway. Serotonin 58-67 alpha-2-glycoprotein 1, zinc-binding Homo sapiens 0-4 14510955-8 2003 Interestingly, despite the absence of clinical symptoms, two relatives carrying only one HPS-1 mutation (insC974) presented a decreased content of platelet-dense granules and showed significant reductions in platelet aggregation, expression of CD63 after platelet activation and serotonin uptake. Serotonin 279-288 HPS1 biogenesis of lysosomal organelles complex 3 subunit 1 Homo sapiens 89-94 34039946-9 2021 In addition, both the decreased level of dopamine (DA) and 5-hydroxytryptamine (5-HT) in serum and hippocampus caused by CUMS were improved after the treatments with acupuncture and fluoxetine, and the decreased expression of brain-derived neurotrophic factor signaling and the astrocytes in the hippocampus caused by CUMS were increased after the treatments with acupuncture and fluoxetine. Serotonin 80-84 brain-derived neurotrophic factor Rattus norvegicus 226-259 30055194-4 2019 In contrast to NET, DAT and SERT, OCT3 has higher capacity and lower affinity for substrates, is sodium-independent, and is multi-specific, with the capacity to transport norepinephrine, dopamine, serotonin and histamine. Serotonin 197-206 OCTN3 Homo sapiens 34-38 14622177-7 2003 Cell aggregates treated with an antibody against FGF-4 or with the serotonergic toxin 5,7-dyhydroxytryptamine or the serotonin synthesis inhibitor dl-p-chlorophenylalanine showed a marked decrease in the number of 5-HT-ir cells (10-20% of controls) and a marked increase in that of TH-ir neurons (700-900% of controls). Serotonin 117-126 fibroblast growth factor 4 Rattus norvegicus 49-54 30382587-5 2019 When activated alone, spinal Gq protein-coupled serotonin 2A receptors (5-HT2A ) initiate pMF by a mechanism that requires ERK-MAP kinase signalling and new BDNF protein synthesis (Q pathway). Serotonin 48-57 brain-derived neurotrophic factor Rattus norvegicus 157-161 34045888-8 2021 In addition, serotonin N-acetyltransferase (NAT) and acetylserotonin methyltransferase (ASMT), the key enzymes in the pathway of melatonin synthesis from serotonin, were also detectable. Serotonin 13-22 bromodomain containing 2 Homo sapiens 44-47 34045888-8 2021 In addition, serotonin N-acetyltransferase (NAT) and acetylserotonin methyltransferase (ASMT), the key enzymes in the pathway of melatonin synthesis from serotonin, were also detectable. Serotonin 13-22 acetylserotonin O-methyltransferase Homo sapiens 88-92 34054418-5 2021 The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism. Serotonin 206-215 vitamin D receptor Homo sapiens 81-99 34054418-5 2021 The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism. Serotonin 206-215 vitamin D receptor Homo sapiens 101-104 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 110-129 indoleamine 2,3-dioxygenase 1 Homo sapiens 372-399 34054418-5 2021 The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism. Serotonin 206-215 tryptophan hydroxylase 2 Homo sapiens 144-168 34054418-5 2021 The signaling of 1,25-dihydroxyvitamin D3, the active form of vitamin D, through vitamin D receptor (VDR) induces the expression of the gene of tryptophan hydroxylase 2 (TPH2), influences the expression of serotonin reuptake transporter (SERT) as well as the levels of monoamine oxidase-A (MAO-A), the enzyme responsible for serotonin catabolism. Serotonin 206-215 tryptophan hydroxylase 2 Homo sapiens 170-174 30031694-2 2018 Serotonin increases the expression of S100A4/Mts1, which in turn stimulates the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH in vitro. Serotonin 0-9 S100 calcium binding protein A4 Homo sapiens 38-44 30031694-2 2018 Serotonin increases the expression of S100A4/Mts1, which in turn stimulates the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH in vitro. Serotonin 0-9 S100 calcium binding protein A4 Homo sapiens 45-49 30031694-2 2018 Serotonin increases the expression of S100A4/Mts1, which in turn stimulates the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH in vitro. Serotonin 0-9 advanced glycosylation end-product specific receptor Homo sapiens 183-187 30031694-2 2018 Serotonin increases the expression of S100A4/Mts1, which in turn stimulates the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH in vitro. Serotonin 0-9 advanced glycosylation end-product specific receptor Homo sapiens 189-233 30031694-2 2018 Serotonin increases the expression of S100A4/Mts1, which in turn stimulates the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH in vitro. Serotonin 0-9 S100 calcium binding protein A4 Homo sapiens 244-250 30031694-2 2018 Serotonin increases the expression of S100A4/Mts1, which in turn stimulates the proliferation and migration of human pulmonary artery smooth muscle cells through the interaction with RAGE (receptor for advanced glycation end products) and thus S100A4/Mts1 has been implicated in the development of PAH in vitro. Serotonin 0-9 S100 calcium binding protein A4 Homo sapiens 251-255 33957677-5 2021 Quantitative real-time RT-PCR was applied to investigate the effect of WN or fluoxetine on the expression of serotonin receptors (ser-1, ser-4, ser-7) and serotonin transporter (mod-5). Serotonin 109-118 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 144-149 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 110-129 indoleamine 2,3-dioxygenase 1 Homo sapiens 401-404 33894423-2 2021 Recent animal models suggest that the anxiolytic effects of OXT are critically mediated by the serotonin (5-HT) system, yet direct evidence in humans is lacking. Serotonin 95-104 oxytocin/neurophysin I prepropeptide Homo sapiens 60-63 33894423-2 2021 Recent animal models suggest that the anxiolytic effects of OXT are critically mediated by the serotonin (5-HT) system, yet direct evidence in humans is lacking. Serotonin 106-110 oxytocin/neurophysin I prepropeptide Homo sapiens 60-63 33894423-3 2021 METHODS: To determine the role of 5-HT in OXT-induced attenuation of amygdala threat reactivity and sensitization/ desensitization, we conducted a parallel-group randomized placebo-controlled double-blind experiment during which n = 121 healthy subjects underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD+) or the corresponding placebo-control protocols before the administration of intranasal OXT or placebo intranasal spray, respectively. Serotonin 34-38 oxytocin/neurophysin I prepropeptide Homo sapiens 42-45 30538587-10 2018 Conclusion: Overall, the results of the in vitro SPN-810M pharmacological studies provide some insight into how SPN-810M modulates the serotonin and dopamine pathways that play a role in IA. Serotonin 135-144 DEAF1 transcription factor Homo sapiens 49-52 30538587-10 2018 Conclusion: Overall, the results of the in vitro SPN-810M pharmacological studies provide some insight into how SPN-810M modulates the serotonin and dopamine pathways that play a role in IA. Serotonin 135-144 DEAF1 transcription factor Homo sapiens 112-115 33894423-3 2021 METHODS: To determine the role of 5-HT in OXT-induced attenuation of amygdala threat reactivity and sensitization/ desensitization, we conducted a parallel-group randomized placebo-controlled double-blind experiment during which n = 121 healthy subjects underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD+) or the corresponding placebo-control protocols before the administration of intranasal OXT or placebo intranasal spray, respectively. Serotonin 288-292 oxytocin/neurophysin I prepropeptide Homo sapiens 42-45 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 131-140 indoleamine 2,3-dioxygenase 1 Homo sapiens 372-399 33894423-5 2021 RESULTS: No treatment main or interaction effects on amygdala threat reactivity were observed, yet OXT switched bilateral amygdala threat sensitization to desensitization and this effect was significantly attenuated during decreased central 5-HT signaling via pretreatment with ATD+ CONCLUSIONS: The present findings provide the first evidence for a role of OXT in threat-specific amygdala desensitization in humans and suggest that these effects are critically mediated by the 5-HT system. Serotonin 241-245 oxytocin/neurophysin I prepropeptide Homo sapiens 99-102 33894423-5 2021 RESULTS: No treatment main or interaction effects on amygdala threat reactivity were observed, yet OXT switched bilateral amygdala threat sensitization to desensitization and this effect was significantly attenuated during decreased central 5-HT signaling via pretreatment with ATD+ CONCLUSIONS: The present findings provide the first evidence for a role of OXT in threat-specific amygdala desensitization in humans and suggest that these effects are critically mediated by the 5-HT system. Serotonin 478-482 oxytocin/neurophysin I prepropeptide Homo sapiens 99-102 30409162-14 2018 Treatment with serotonin receptor antagonists 5-HTr1B and 5-HTr2B reduced serotonin-mediated cell steatosis; in contrast, treatment with selective serotonin reuptake inhibitors (SSRIs) increased steatosis. Serotonin 15-24 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 60-65 33894423-6 2021 OXT may have a therapeutic potential to facilitate amygdala desensitization and adjunct up-regulation of 5-HT neurotransmission may facilitate OXT"s anxiolytic potential. Serotonin 105-109 oxytocin/neurophysin I prepropeptide Homo sapiens 143-146 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 131-140 indoleamine 2,3-dioxygenase 1 Homo sapiens 401-404 12767050-2 2003 Evaluation of serotonin (5HT), melatonin (MT), and melatonin-related receptors (MRR) showed expression of the isoforms 5HT2B, 5HT7, and MT1 genes in almost all the tested samples. Serotonin 14-23 metallothionein 1I, pseudogene Homo sapiens 136-139 33917814-5 2021 Results showed increased hippocampal ROS and NOX2 levels, serotonin turnover, kynurenine, and noradrenaline contents in Abeta-treated rats. Serotonin 58-67 amyloid beta precursor protein Rattus norvegicus 120-125 30058725-0 2018 Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas. Serotonin 0-9 Rac family small GTPase 1 Homo sapiens 33-37 30058725-0 2018 Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas. Serotonin 0-9 KRAS proto-oncogene, GTPase Homo sapiens 52-56 12749894-3 2003 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT(1A) receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities. Serotonin 139-148 5-hydroxytryptamine receptor 1A Homo sapiens 117-134 30105641-2 2018 Experiments were performed to find out whether the RRF-induced relaxation is influenced by serotonin, glutamate, L-cysteine, the cytochrome P450 pathway, the cyclooxygenase pathway, or oxidative stress. Serotonin 91-100 mitochondrial ribosome recycling factor Mus musculus 51-54 32575133-8 2021 Aripiprazole also partially agonises D3 receptors and serotonin 2 C receptors (5-HT2 C), which may contribute to its antidepressant properties. Serotonin 54-63 5-hydroxytryptamine receptor 2C Homo sapiens 79-86 33156956-3 2021 Here we demonstrated that the serotonin receptor 4 (5-HT4 R) is expressed in hippocampal astrocytes, both in vitro and in vivo. Serotonin 30-39 5-hydroxytryptamine receptor 4 Homo sapiens 52-59 12706246-4 2003 All neurons (>98%) examined in catecholamine groups A1, A2, A5, A6, C1, and serotonin groups B1-3 and B6-8 were immunoreactive for the GABA(B)R1 subunit. Serotonin 79-88 gamma-aminobutyric acid (GABA) B receptor, 1 Mus musculus 138-147 33464458-2 2021 Although the underlying mechanism remains unknown, the type-1A serotonin receptor (5-HT1A) and cannabinoids type-1 (CB1) and type-2 (CB2) receptors seem to play a central role in mediating the beneficial effects on emotional responses. Serotonin 63-72 cannabinoid receptor 1 Rattus norvegicus 116-119 12706246-8 2003 In general, our results suggest that GABA(B)R1 and GABA(B)R2 co-exist in the great majority of brainstem catecholamine and serotonin neurons. Serotonin 123-132 gamma-aminobutyric acid (GABA) B receptor, 1 Mus musculus 37-46 33723417-4 2021 Here we report that the p11/SMARCA3 complex represses Neurensin-2 transcription in hippocampal parvalbumin-expressing interneurons after chronic treatment with Selective Serotonin Reuptake Inhibitors (SSRI). Serotonin 170-179 neurensin 2 Homo sapiens 54-65 33723417-4 2021 Here we report that the p11/SMARCA3 complex represses Neurensin-2 transcription in hippocampal parvalbumin-expressing interneurons after chronic treatment with Selective Serotonin Reuptake Inhibitors (SSRI). Serotonin 170-179 parvalbumin Homo sapiens 95-106 33112414-8 2021 Finally, in vitro addition of serotonin and treatment of MDD patients with selective serotonin reuptake inhibitors (SSRIs) reduced the production of Th17/Tc17-related cytokines by CD4+ and CD8+ T-cells in response to Pam3C and LPS. Serotonin 30-39 CD8a molecule Homo sapiens 189-192 33112414-8 2021 Finally, in vitro addition of serotonin and treatment of MDD patients with selective serotonin reuptake inhibitors (SSRIs) reduced the production of Th17/Tc17-related cytokines by CD4+ and CD8+ T-cells in response to Pam3C and LPS. Serotonin 85-94 CD8a molecule Homo sapiens 189-192 30019623-5 2018 We found that 1) pro- and anti-inflammatory cytokine levels in the brain injury area were differentially regulated in a time-dependent manner post-injury; 2) indoleamine 2,3 dioxygeenase 1 (IDO1) was upregulated around the injury area in TBI kits that persisted at 21 days post-injury; 3) mean length of serotonin-staining fibers was significantly reduced in the injured brain region in TBI kits for at least 21 days post-injury; and 4) kynurenine level significantly increased at 7 days post-injury. Serotonin 304-313 indoleamine 2,3-dioxygenase 1 Oryctolagus cuniculus 158-188 30019623-5 2018 We found that 1) pro- and anti-inflammatory cytokine levels in the brain injury area were differentially regulated in a time-dependent manner post-injury; 2) indoleamine 2,3 dioxygeenase 1 (IDO1) was upregulated around the injury area in TBI kits that persisted at 21 days post-injury; 3) mean length of serotonin-staining fibers was significantly reduced in the injured brain region in TBI kits for at least 21 days post-injury; and 4) kynurenine level significantly increased at 7 days post-injury. Serotonin 304-313 indoleamine 2,3-dioxygenase 1 Oryctolagus cuniculus 190-194 30057120-6 2018 Neuronal expression of the Wnt ligand/EGL-20 is sufficient to induce cell-non-autonomous UPRmt in a retromer complex-, Wnt signaling-, and serotonin-dependent manner, clearly implicating Wnt signaling as a strong candidate for the "mitokine" signal. Serotonin 139-148 Uncharacterized protein Caenorhabditis elegans 38-44 12629664-7 2003 BDNF mainly colocalizes with markers of type II and type III taste cells: ubiquitin carboxyl terminal hydrolase (PGP 9.5), serotonin (5-HT), neural cell adhesion molecule (N-CAM), synaptic associated protein of 25 kDa (SNAP-25), and to a lesser extent with alpha-gustducin. Serotonin 123-132 brain derived neurotrophic factor Mus musculus 0-4 33599748-1 2021 BACKGROUND: To investigate the function of transient receptor potential melastatin 2 (TRPM2) in vascular reactivity induced by 5-hydroxytryptamine (5-HT) in the aorta during development of atherosclerosis in mice. Serotonin 127-146 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 43-84 12660805-7 2003 These findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis that CRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects. Serotonin 91-100 corticotropin releasing hormone Homo sapiens 27-30 33599748-1 2021 BACKGROUND: To investigate the function of transient receptor potential melastatin 2 (TRPM2) in vascular reactivity induced by 5-hydroxytryptamine (5-HT) in the aorta during development of atherosclerosis in mice. Serotonin 127-146 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 86-91 33599748-1 2021 BACKGROUND: To investigate the function of transient receptor potential melastatin 2 (TRPM2) in vascular reactivity induced by 5-hydroxytryptamine (5-HT) in the aorta during development of atherosclerosis in mice. Serotonin 148-152 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 43-84 33599748-1 2021 BACKGROUND: To investigate the function of transient receptor potential melastatin 2 (TRPM2) in vascular reactivity induced by 5-hydroxytryptamine (5-HT) in the aorta during development of atherosclerosis in mice. Serotonin 148-152 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 86-91 12660805-7 2003 These findings reveal that CRH-IR levels are specifically increased in norepinephrine- and serotonin-containing pontine nuclei of depressed suicide men, and thus they are consistent with the hypothesis that CRH neurotransmission is elevated in extra-hypothalamic brain regions of depressed subjects. Serotonin 91-100 corticotropin releasing hormone Homo sapiens 207-210 33599748-8 2021 The enhanced reactivity to 5-HT was significantly inhibited by TRPM2 inhibitors, N-p-amylcinnamoyl anthranilic acid (1 micromol/l) and 2-aminoethyl diphenylborinate (10 micromol/l). Serotonin 27-31 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 63-68 12701881-13 2003 A cross-talk between insulin and leptin receptors has been observed in the brain, and a regulation of central insulin actions, potentially via serotonin modulation, by leptin, galanin, melancortins, and neuropeptide Y (NPY) is suggested. Serotonin 143-152 neuropeptide Y Homo sapiens 203-217 33599748-10 2021 Upregulation of TRPM2 enhances 5-HT vascular reactivity during development of atherosclerosis. Serotonin 31-35 transient receptor potential cation channel, subfamily M, member 2 Mus musculus 16-21 14584974-1 2003 Xaliproden [SR 57746A, xaliprodene; Xaprila] is a compound that mimics the effects of nerve growth factor and is also a serotonin 5-HT1A receptor agonist. Serotonin 120-129 5-hydroxytryptamine receptor 1A Homo sapiens 130-145 33633868-10 2021 In view of these findings, we conclude that acupuncture may produce therapeutic effects on autism by triggering the hypothalamic oxytocin system, which in turn activates the release of neurotransmitters such as endocannabinoids, dopamine and serotonin. Serotonin 242-251 oxytocin Mus musculus 129-137 12536053-3 2003 [11C] alpha-methyl-L-tryptophan (alpha-MTrp) was originally developed to measure serotonin synthesis in vivo with positron emission tomography (PET). Serotonin 81-90 lysosomal protein transmembrane 4 alpha Homo sapiens 39-43 33352109-4 2021 Microbial, pharmacological, or optogenetic activation of Trpa1+EECs directly stimulates vagal sensory ganglia and activates cholinergic enteric neurons by secreting the neurotransmitter 5-hydroxytryptamine (5-HT). Serotonin 186-205 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 57-62 33352109-4 2021 Microbial, pharmacological, or optogenetic activation of Trpa1+EECs directly stimulates vagal sensory ganglia and activates cholinergic enteric neurons by secreting the neurotransmitter 5-hydroxytryptamine (5-HT). Serotonin 207-211 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 57-62 33603523-4 2021 Serotonin/T-HydroxyTriptamine (5-HT) plays a key role in ventilatory stimulation, while the polymorphism of the serotonin transporter gene (STG) leads to alterations in serotonin level, making it important in OSA. Serotonin 0-9 chromosome 6 open reading frame 15 Homo sapiens 140-143 12454997-12 2003 The ventromedial group of calbindin-immunoreactive neurons also is immunoreactive for serotonin and, therefore, represents the ventromedial group of dopamine/serotonin spinal neurons. Serotonin 86-95 calbindin 1 Homo sapiens 26-35 33537987-3 2021 Among them, clozapine is one of the atypical antipsychotics prescribed in schizophrenia wing to its blocking effect on dopamine (D2) and serotonin (5-HT1c ) receptors. Serotonin 137-146 5-hydroxytryptamine receptor 2C Rattus norvegicus 148-154 33536397-1 2022 AIM: Previously, we found that diabetes-related liver dysfunction is due to activation of the 5-HT2A receptor (5-HT2AR) and increased synthesis and degradation of 5-HT. Serotonin 94-98 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 111-118 12454997-12 2003 The ventromedial group of calbindin-immunoreactive neurons also is immunoreactive for serotonin and, therefore, represents the ventromedial group of dopamine/serotonin spinal neurons. Serotonin 158-167 calbindin 1 Homo sapiens 26-35 33441874-7 2021 A significant upregulation of serotonin receptors, Htr2a and Htr2c, was observed in the bladders from mice with constipation, paralleled with augmented spontaneous contractions after pre-incubation of the bladder strips with 0.5 microM of serotonin. Serotonin 30-39 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 51-56 12852256-1 2003 Serotonin (5-hydroxytryptamine, 5-HT)-containing neurons in the midbrain directly innervate corticotropin-releasing hormone (CRH)-containing cells located in paraventricular nucleus of the hypothalamus. Serotonin 0-9 corticotropin releasing hormone Homo sapiens 92-123 33441874-7 2021 A significant upregulation of serotonin receptors, Htr2a and Htr2c, was observed in the bladders from mice with constipation, paralleled with augmented spontaneous contractions after pre-incubation of the bladder strips with 0.5 microM of serotonin. Serotonin 239-248 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 51-56 33369003-3 2021 5HT2A receptor (5HT2A R) is a subtype of 5HT2 receptor belonging to the serotonin receptor family, and its antagonists have been clinically used as antipsychotics to relieve psychopathy. Serotonin 72-81 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 0-14 12852256-1 2003 Serotonin (5-hydroxytryptamine, 5-HT)-containing neurons in the midbrain directly innervate corticotropin-releasing hormone (CRH)-containing cells located in paraventricular nucleus of the hypothalamus. Serotonin 0-9 corticotropin releasing hormone Homo sapiens 125-128 33369003-3 2021 5HT2A receptor (5HT2A R) is a subtype of 5HT2 receptor belonging to the serotonin receptor family, and its antagonists have been clinically used as antipsychotics to relieve psychopathy. Serotonin 72-81 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 16-23 12852256-1 2003 Serotonin (5-hydroxytryptamine, 5-HT)-containing neurons in the midbrain directly innervate corticotropin-releasing hormone (CRH)-containing cells located in paraventricular nucleus of the hypothalamus. Serotonin 11-30 corticotropin releasing hormone Homo sapiens 92-123 12852256-1 2003 Serotonin (5-hydroxytryptamine, 5-HT)-containing neurons in the midbrain directly innervate corticotropin-releasing hormone (CRH)-containing cells located in paraventricular nucleus of the hypothalamus. Serotonin 11-30 corticotropin releasing hormone Homo sapiens 125-128 12391366-3 2002 They hypothesize that CSF serotonin may be acting in an endocrine-like manner through activation of known leptomeningeal serotonin receptors and possibly participating in modulation of choroidal production of CSF. Serotonin 26-35 colony stimulating factor 2 Homo sapiens 22-25 32935845-1 2021 The type 4 serotonin receptor (5-HT4R) is highly involved in cognitive processes such as learning and memory. Serotonin 11-20 5-hydroxytryptamine receptor 4 Homo sapiens 31-37 12391366-3 2002 They hypothesize that CSF serotonin may be acting in an endocrine-like manner through activation of known leptomeningeal serotonin receptors and possibly participating in modulation of choroidal production of CSF. Serotonin 26-35 colony stimulating factor 2 Homo sapiens 209-212 12374464-8 2002 The signaling between the OTR and the SERT was analyzed by measuring the extent of inhibition of OT and PMA (activator of protein kinase C on 5HT uptake and the capability of Ro318220 (specific inhibitor of PKC) to increase 5HT uptake and block the effect of the above compounds in mast cells. Serotonin 142-145 oxytocin receptor Mus musculus 26-29 32731218-0 2021 Association of Serum Biomarker Levels and BDNF Gene Polymorphism with Response to Selective Serotonin Reuptake Inhibitors in Indian Patients with Major Depressive Disorder. Serotonin 92-101 brain derived neurotrophic factor Homo sapiens 42-46 12374464-8 2002 The signaling between the OTR and the SERT was analyzed by measuring the extent of inhibition of OT and PMA (activator of protein kinase C on 5HT uptake and the capability of Ro318220 (specific inhibitor of PKC) to increase 5HT uptake and block the effect of the above compounds in mast cells. Serotonin 224-227 oxytocin receptor Mus musculus 26-29 33785138-5 2021 The effect of 5-HT on STN neuronal activity involves several 5-HT receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT2C and 5-HT4 receptors, which have garnered the highest attention on this topic. Serotonin 14-18 5-hydroxytryptamine receptor 2C Homo sapiens 111-117 33785138-5 2021 The effect of 5-HT on STN neuronal activity involves several 5-HT receptor subtypes, including 5-HT1A, 5-HT1B, 5-HT2C and 5-HT4 receptors, which have garnered the highest attention on this topic. Serotonin 61-65 5-hydroxytryptamine receptor 2C Homo sapiens 111-117 12374464-9 2002 The results showed that in murine peritoneal mast cells in vitro (1) ovarian hormones modulate OTR but not SERT expression, (2) the magnitude of OT action on 5HT uptake depends on the number of OTRs expressed in mast cells, and (3) the signaling between OTR and the SERT is mediated through the activation of protein kinase C. It is concluded that the ovarian hormones have a modulatory action on 5HT uptake which involves OT-mediated mechanism. Serotonin 158-161 oxytocin receptor Mus musculus 194-197 12021050-0 2002 Serotonergic activation rescues reproductive function in fasted mice: does serotonin mediate the metabolic effects of leptin on reproduction? Serotonin 75-84 leptin Mus musculus 118-124 33372187-2 2020 Vitamin D has been shown to stimulate the expression of the tryptophan hydroxylase 2 (TPH2) gene, which is the rate-limiting enzyme for serotonin production in the brain. Serotonin 136-145 tryptophan hydroxylase 2 Homo sapiens 60-84 33372187-2 2020 Vitamin D has been shown to stimulate the expression of the tryptophan hydroxylase 2 (TPH2) gene, which is the rate-limiting enzyme for serotonin production in the brain. Serotonin 136-145 tryptophan hydroxylase 2 Homo sapiens 86-90 11992564-2 2002 Serotonin 1A (5-HT1A) receptors are known to be located on serotonergic nerve terminals and to be involved in the presynaptic regulation of serotonin release. Serotonin 140-149 5-hydroxytryptamine receptor 1A Homo sapiens 14-20 11985883-1 2002 The role of arylalkylamine N-acetyltransferase (AANAT) in neuronal functioning has been suggested based on biochemical assays; only scarce evidence indicates neuronal expression of the mRNA encoding for this enzyme that catalyzes the conversion of serotonin into N-acetylserotonin. Serotonin 248-257 aralkylamine N-acetyltransferase Rattus norvegicus 12-46 33249495-5 2020 We also found the upregulation of serotonin and brain derived neurotrophic factor expression in the c-fos-positive areas of rats treated with blue light compared with those maintained in darkness. Serotonin 34-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 100-105 33270791-4 2020 This study aimed to demonstrate the effects of a tricyclic antidepressant (amitriptyline) and a selective 5-hydroxy-tryptamine 2A (5-HT2A) antagonist (MDL 100907) that adjust serotonergic transmission, on secondary sleep disturbance induced in a preclinical chronic pain model. Serotonin 106-126 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 131-137 32958730-7 2020 GLR-1 further positively affected the function of SER-7-mediated serotonin signaling and antagonized the function of DAT-1-mediated dopamine signaling in the regulation of innate immune response to fungal infection. Serotonin 65-74 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 50-55 11985883-1 2002 The role of arylalkylamine N-acetyltransferase (AANAT) in neuronal functioning has been suggested based on biochemical assays; only scarce evidence indicates neuronal expression of the mRNA encoding for this enzyme that catalyzes the conversion of serotonin into N-acetylserotonin. Serotonin 248-257 aralkylamine N-acetyltransferase Rattus norvegicus 48-53 11880646-8 2002 As compared with platelets from wild-type littermates, CDCrel-1(Null) platelets aggregate and release stored [14C]serotonin in the presence of subthreshold levels of collagen. Serotonin 114-123 septin 5 Mus musculus 55-63 33237915-4 2020 Thus, the objective of this study was to determine if genetic ablation or pharmacological antagonism of the 5-HT2B serotonin receptor (gene: Htr2b) could improve the hemodynamic and histological progression of calcific aortic valve disease. Serotonin 115-124 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 141-146 11945082-1 2002 A feature of pre-eclampsia is that circulating levels of maternal serotonin (5-hydroxytryptamine) are elevated and placental monoamine oxidase-A (MAO-A) activity, the major factor in the regulation of serotonin levels in pregnancy, is reduced. Serotonin 201-210 monoamine oxidase A Homo sapiens 125-144 33262643-11 2020 Results: The results demonstrated that Tph, the rate-limiting enzyme in 5-HT synthesis, was significantly upregulated in the RVM, and that spinal 5-HT release was increased in CIPN rats. Serotonin 72-76 tryptophan hydroxylase 1 Rattus norvegicus 39-42 33262643-12 2020 Intra-RVM microinjection of Tph inhibitor PCPA significantly attenuated mechanical and thermal pain behavior through Tph downregulation and decreased spinal 5-HT. Serotonin 157-161 tryptophan hydroxylase 1 Rattus norvegicus 28-31 11945082-1 2002 A feature of pre-eclampsia is that circulating levels of maternal serotonin (5-hydroxytryptamine) are elevated and placental monoamine oxidase-A (MAO-A) activity, the major factor in the regulation of serotonin levels in pregnancy, is reduced. Serotonin 201-210 monoamine oxidase A Homo sapiens 146-151 11945082-2 2002 It is not known whether this is due to a reduced MAO-A protein content or a reduced catalytic turnover of the serotonin by MAO-A; this question has been addressed in the present work. Serotonin 110-119 monoamine oxidase A Homo sapiens 123-128 11812236-7 2002 The steady-state kinetic properties of P. pastoris-expressed MAO-A are similar to those of S. cerevisiae-expressed MAO-A using the following substrates: phenethylamine, p-CF(3)-benzylamine, dopamine, serotonin, and kynuramine. Serotonin 200-209 monoamine oxidase A Homo sapiens 61-66 33485192-3 2021 To this end, we have constructed isoform-specific inhibitors of the human cytosolic sulfotransferase 1A3 (SULT1A3)-the isoform responsible for sulfonating ~80% of the serotonin in the extracellular brain fluid. Serotonin 167-176 sulfotransferase family 1A member 3 Homo sapiens 106-113 11812236-7 2002 The steady-state kinetic properties of P. pastoris-expressed MAO-A are similar to those of S. cerevisiae-expressed MAO-A using the following substrates: phenethylamine, p-CF(3)-benzylamine, dopamine, serotonin, and kynuramine. Serotonin 200-209 monoamine oxidase A Homo sapiens 115-120 33214666-4 2020 In myeloid precursors, the granulocyte-macrophage progenitors (GMPs), loss of NSP4 results in the decrease of cellular levels of histamine, serotonin and heparin/heparan sulfate. Serotonin 140-149 protease, serine 57 Mus musculus 78-82 12143407-18 2002 Serotonin, by acting on the astroglial 5-HT1A receptor, releases S-100 beta and regulates neuronal morphology and apoptosis. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 39-54 32942081-1 2020 Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine, serotonin, and some other amines. Serotonin 175-184 monoamine oxidase B Homo sapiens 30-35 11742209-0 2001 Serotonin induces a decrease of 5-HT(1A) immunoreactivity in organotypic hippocampal cultures. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 32-39 33168874-1 2020 5-HT inhibits cardiac sympathetic neurotransmission in normoglycaemic rats, via 5-HT1B, 5-HT1D and 5-HT5A receptor activation. Serotonin 0-4 5-hydroxytryptamine receptor 1B Rattus norvegicus 80-86 11742209-2 2001 However, the effect of increased levels of serotonin on postsynaptic 5-HT(1A) receptor density is unknown. Serotonin 43-52 5-hydroxytryptamine receptor 1A Homo sapiens 69-86 32871117-6 2020 Metabolism of Trp to serotonin and its metabolites resulted in an increase in 5-Hydroxyindole-3-acetic acid in the Tdo2 and dual KO mice. Serotonin 21-30 tryptophan 2,3-dioxygenase Mus musculus 115-119 11742209-3 2001 The purpose of this study was to investigate, in a culture model, how postsynaptic 5-HT(1A) receptors are influenced by serotonin. Serotonin 120-129 5-hydroxytryptamine receptor 1A Homo sapiens 83-90 29738736-4 2018 One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine. Serotonin 268-277 OCTN3 Homo sapiens 146-174 11742209-6 2001 5-HT(1A) levels decreased with increasing serotonin concentrations, being significant at 10, 50 and 100 microM. Serotonin 42-51 5-hydroxytryptamine receptor 1A Homo sapiens 0-7 29738736-4 2018 One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine. Serotonin 268-277 OCTN3 Homo sapiens 176-180 33061309-18 2020 Conclusion: This suggests that the antiemetic effect of [6]-gingerol against cisplatin-induced emesis may be due to 5-HT attenuation via modulating the TPH/MAO-A/SERT/5-HT/5-HT3 receptor system. Serotonin 116-120 tryptophan hydroxylase 1 Rattus norvegicus 152-155 11742209-7 2001 These results indicate that at increasing serotonin levels the density of postsynaptic 5-HT(1A) receptors is down-regulated. Serotonin 42-51 5-hydroxytryptamine receptor 1A Homo sapiens 87-94 11723272-0 2001 Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 10-16 11588191-0 2001 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization. Serotonin 0-19 tachykinin 1 Mus musculus 62-73 32338242-4 2020 A variant (rs4570625) of the gene encoding tryptophan hydroxylase 2 (TPH2) that is responsible for the synthesis of central serotonin was genotyped. Serotonin 124-133 tryptophan hydroxylase 2 Homo sapiens 43-67 32338242-4 2020 A variant (rs4570625) of the gene encoding tryptophan hydroxylase 2 (TPH2) that is responsible for the synthesis of central serotonin was genotyped. Serotonin 124-133 tryptophan hydroxylase 2 Homo sapiens 69-73 32712253-10 2020 Injection of SCAP BDNF-PAMs at the lesion site improved rat BBB scoring, reduced the expression of inducible nitric oxide synthase and increased the expression of betaIII tubulin, GAP43, and 5-HT. Serotonin 191-195 brain-derived neurotrophic factor Rattus norvegicus 18-22 29649585-9 2018 RESULTS: Elevated serum serotonin levels were significantly reduced after 5-HT2A antagonist treatment as was 5-HT2A receptor expression. Serotonin 24-33 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 74-80 29798691-6 2018 However, TAAR1"s influences on serotonin and glutamate neurotransmission will also be highlighted. Serotonin 31-40 trace amine associated receptor 1 Homo sapiens 9-14 29798691-9 2018 Continued focus on the mechanisms underlying TAAR1"s regulation of serotonin and glutamate signaling, as well as dopamine, will yield further disease-relevant insights. Serotonin 67-76 trace amine associated receptor 1 Homo sapiens 45-50 11588191-0 2001 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization. Serotonin 0-19 tachykinin 1 Mus musculus 75-87 29453444-9 2018 In Htr2b 5-HTKO mice, dorsal raphe serotonin neurons displayed a lower firing frequency compared to control Htr2b lox/lox mice as assessed by in vivo extracellular recordings and a stronger hypothermic effect of 5-HT1A-autoreceptor stimulation was observed. Serotonin 35-44 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 3-8 32512137-5 2020 Furthermore, corticosterone administration into male rats as a rodent model of depression induced significantly higher c-Fos expression in 5-HT3AR-positive GABAergic neurons compared to that in 5-HT neurons within the DRN. Serotonin 139-143 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 119-124 11595206-3 2001 Diazepam (0.1 mg/kg) and the 5-HT(1A) receptor agonist 8-OH-DPAT (0.003 and 0.01 mg/kg) also increased social interaction, whereas an acute dose of the selective serotonin re-uptake inhibitor fluoxetine (10 mg/kg) decreased the time spent in social interaction. Serotonin 162-171 5-hydroxytryptamine receptor 1A Homo sapiens 29-46 32267363-0 2020 ARMC5 mutations are associated with high levels of proliferating cell nuclear antigen and the presence of the serotonin receptor 5HT4R in PMAH nodules. Serotonin 110-119 5-hydroxytryptamine receptor 4 Homo sapiens 129-134 29453444-11 2018 Together, these observations indicate that the 5-HT2B receptor acts as a direct positive modulator of serotonin Pet1-positive neurons in an opposite way as the known 5-HT1A-negative autoreceptor. Serotonin 102-111 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 47-53 29524394-2 2018 The current study aimed to clarify the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the enzymatic characteristics of the sulfation of dopamine, epinephrine, norepinephrine and serotonin by SULT1A3 allozymes. Serotonin 219-228 sulfotransferase family 1A member 3 Homo sapiens 98-105 11579128-1 2001 alpha-Methyl-L-tryptophan (alpha-MTrp) is an artificial amino acid and an analog of tryptophan (Trp), the precursor of the neurotransmitter serotonin (5-HT). Serotonin 140-149 lysosomal protein transmembrane 4 alpha Homo sapiens 33-37 29524394-6 2018 Purified SULT1A3 allozymes exhibited differential sulfating activity toward catecholamines and serotonin. Serotonin 95-104 sulfotransferase family 1A member 3 Homo sapiens 9-16 29524394-8 2018 Collectively, these findings provide useful information relevant to the differential metabolism of dopamine, epinephrine, norepinephrine and serotonin through sulfoconjugation in individuals having different SULT1A3/SULT1A4 genotypes. Serotonin 141-150 sulfotransferase family 1A member 3 Homo sapiens 208-215 29081505-7 2018 In parallel, serotonin led to 3-6-fold reduction in the gene expression of brown adipocyte differentiation markers, that is, Prdm16 (positive regulatory domain 16), Bmp7 (bone morphogenic protein 7) and Ppargamma (peroxisome-proliferator-activated receptor gamma). Serotonin 13-22 PR domain containing 16 Mus musculus 125-131 29081505-7 2018 In parallel, serotonin led to 3-6-fold reduction in the gene expression of brown adipocyte differentiation markers, that is, Prdm16 (positive regulatory domain 16), Bmp7 (bone morphogenic protein 7) and Ppargamma (peroxisome-proliferator-activated receptor gamma). Serotonin 13-22 PR domain containing 16 Mus musculus 133-162 29081505-7 2018 In parallel, serotonin led to 3-6-fold reduction in the gene expression of brown adipocyte differentiation markers, that is, Prdm16 (positive regulatory domain 16), Bmp7 (bone morphogenic protein 7) and Ppargamma (peroxisome-proliferator-activated receptor gamma). Serotonin 13-22 bone morphogenetic protein 7 Mus musculus 165-169 32418902-8 2020 In addition, AMPKalpha deletion significantly fortified 5-HT- or DSS-induced downregulations of cytoprotective signaling pathways (Nrf2, HIF-1alpha, and KLF4). Serotonin 56-60 Kruppel like factor 4 Homo sapiens 153-157 32305492-9 2020 In addition, our data demonstrated that decreased serotonin and increased homovanillic acid emerged after probiotics + FOS intervention. Serotonin 50-59 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 119-122 32305492-11 2020 Probiotics + FOS intervention can modulate gut microbiota, SCFAs and serotonin in association with improved ASD symptoms, including a hyper-serotonergic state and dopamine metabolism disorder. Serotonin 69-78 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 13-16 29081505-7 2018 In parallel, serotonin led to 3-6-fold reduction in the gene expression of brown adipocyte differentiation markers, that is, Prdm16 (positive regulatory domain 16), Bmp7 (bone morphogenic protein 7) and Ppargamma (peroxisome-proliferator-activated receptor gamma). Serotonin 13-22 bone morphogenetic protein 7 Mus musculus 171-197 11771247-0 2001 [Effect of serotonin on the development of luteinizing hormone-releasing hormone system in Wistar rat embryos]. Serotonin 11-20 gonadotropin releasing hormone 1 Rattus norvegicus 43-80 29487480-2 2018 Euphoria, arousal, and decreased anxiety observed with moderate use and exercise may involve enhanced cerebral serotonin synthesis and function by increased release of albumin-bound Trp and estrogen-mediated liver Trp 2,3-dioxygenase (TDO) inhibition and enhancement of serotonin function. Serotonin 270-279 tryptophan 2,3-dioxygenase Homo sapiens 235-238 29487480-3 2018 Aggression, anxiety, depression, personality disorders, and psychosis, observed on withdrawal of AAS or with use of large doses, can be caused by decreased serotonin synthesis due to TDO induction on withdrawal, excess Trp inhibiting the 2 enzymes of serotonin synthesis, and increased cerebral levels of neuroactive kynurenines. Serotonin 156-165 tryptophan 2,3-dioxygenase Homo sapiens 183-186 32354877-3 2020 Here, we found that serotonin N-acetyltransferase1 (SNAT1) and caffeic acid O-methyltransferase (COMT) genes were ubiquitously and highly expressed and essential for melatonin biosynthesis in A. thaliana developing seeds. Serotonin 20-29 O-methyltransferase 1 Arabidopsis thaliana 97-101 11454948-3 2001 In the present study, we examined the effects of PD098059 and U0126, two structurally dissimilar inhibitors of MAP kinase kinase (MEK1/2), on the activation of ERK and Akt stimulated by human 5-hydroxytryptamine(1B) (serotonin) (5-HT1B) receptors. Serotonin 192-211 mitogen-activated protein kinase kinase 1 Homo sapiens 130-136 31868091-10 2020 Additionally, 5-HT1AR and 5-HTT, two genes that regulate 5-HT activity were up-regulated during the middle of the light cycle. Serotonin 14-18 huntingtin Rattus norvegicus 28-31 11400181-1 2001 By using a combination of positron emission tomography (PET) and postmortem tissue dissection, the effect of increased endogenous serotonin on specific binding of [(11)C]WAY 100635 to the 5-HT(1A) receptor was investigated in rat brain in vivo. Serotonin 130-139 5-hydroxytryptamine receptor 1A Homo sapiens 188-205 29082818-3 2018 Agomelatine is a melatonin (MT1/MT2) agonist and serotonin (5-HT2C) antagonist purported to be anxiolytic in clinical and some pre-clinical studies. Serotonin 49-58 5-hydroxytryptamine receptor 2C Rattus norvegicus 60-66 11340335-4 2001 High degrees of co-existence of leptin receptor immunoreactivity with serotonin in the raphe system were observed in B1, B5, B6, B7, B8 and B9. Serotonin 70-79 leptin receptor Rattus norvegicus 32-47 29367674-1 2018 Tryptophan hydroxylase (TRH) is the rate limiting enzyme in the serotonin synthesis. Serotonin 64-73 thyrotropin releasing hormone Mus musculus 24-27 29367674-3 2018 Mono-allelic indel TRH-/+ clones showed normal levels of serotonin, measured by both immunohistochemistry and mass spectrometry (LC-MS/MS), whereas bi-allelic indel TRH-/- clones showed no detectable levels of serotonin. Serotonin 57-66 thyrotropin releasing hormone Mus musculus 19-22 29367674-8 2018 Results obtained with the TRH mutants are in line with reported ones in TRH knockouts of Caenorhabditis elegans, Drosophila and mice, indicating that there is one gene encoding TRH, which is the serotonin limiting enzyme in both the central and the periphery nervous system in Daphnia and that deprivation of serotonin increases anxiety-like behavior. Serotonin 195-204 thyrotropin releasing hormone Mus musculus 26-29 29367674-8 2018 Results obtained with the TRH mutants are in line with reported ones in TRH knockouts of Caenorhabditis elegans, Drosophila and mice, indicating that there is one gene encoding TRH, which is the serotonin limiting enzyme in both the central and the periphery nervous system in Daphnia and that deprivation of serotonin increases anxiety-like behavior. Serotonin 195-204 thyrotropin releasing hormone Mus musculus 72-75 29367674-8 2018 Results obtained with the TRH mutants are in line with reported ones in TRH knockouts of Caenorhabditis elegans, Drosophila and mice, indicating that there is one gene encoding TRH, which is the serotonin limiting enzyme in both the central and the periphery nervous system in Daphnia and that deprivation of serotonin increases anxiety-like behavior. Serotonin 195-204 thyrotropin releasing hormone Mus musculus 72-75 29367674-8 2018 Results obtained with the TRH mutants are in line with reported ones in TRH knockouts of Caenorhabditis elegans, Drosophila and mice, indicating that there is one gene encoding TRH, which is the serotonin limiting enzyme in both the central and the periphery nervous system in Daphnia and that deprivation of serotonin increases anxiety-like behavior. Serotonin 309-318 thyrotropin releasing hormone Mus musculus 26-29 32532168-1 2021 Tryptophan hydroxylase-2 mRNA (TPH, the rate limiting enzyme in 5-HT synthesis) expression levels display circadian variations in the median and dorsal raphe nuclei. Serotonin 64-68 tryptophan hydroxylase 2 Rattus norvegicus 0-24 32532168-1 2021 Tryptophan hydroxylase-2 mRNA (TPH, the rate limiting enzyme in 5-HT synthesis) expression levels display circadian variations in the median and dorsal raphe nuclei. Serotonin 64-68 tryptophan hydroxylase 1 Rattus norvegicus 31-34 32532168-9 2021 The present results suggest that TPH2 mRNA expression pattern within DR and MR is affected by photoperiod which might in turn affect TPH content and 5-HT release within the circadian structures, but also in all the serotonergic projection areas of the brain. Serotonin 149-153 tryptophan hydroxylase 2 Rattus norvegicus 33-37 32532168-9 2021 The present results suggest that TPH2 mRNA expression pattern within DR and MR is affected by photoperiod which might in turn affect TPH content and 5-HT release within the circadian structures, but also in all the serotonergic projection areas of the brain. Serotonin 149-153 tryptophan hydroxylase 1 Rattus norvegicus 33-36 32393533-4 2020 First, we assessed the association of region-specific expression of the serotonin transporter (SLC6A4) and serotonin receptor (HTR1A, HTR2A, HTR2C) genes with anxiety-like behavior and second, we investigated their causal role in two key features of the high trait anxious phenotype: high responsivity to anxiety-provoking stimuli, and an exaggerated conditioned threat response. Serotonin 72-81 sodium-dependent serotonin transporter Callithrix jacchus 95-101 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase A Homo sapiens 7-12 32253244-2 2020 In fact, pro- and anti-inflammatory macrophages differ in the expression of serotonin receptors, with 5-HT2B and 5-HT7 expression restricted to M-CSF-primed monocyte-derived macrophages (M-MO). Serotonin 76-85 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 102-108 32281745-2 2020 This study investigates the effect of chronic administration of the serotonin-norepinephrine reuptake inhibitor, venlafaxine, on the expression and methylation status of SOD1, SOD2, GPx1, GPx4, CAT, NOS1 and NOS2 in the brain and blood of rats exposed to a chronic mild stress (CMS) model of depression. Serotonin 68-77 superoxide dismutase 2 Rattus norvegicus 176-180 32281745-2 2020 This study investigates the effect of chronic administration of the serotonin-norepinephrine reuptake inhibitor, venlafaxine, on the expression and methylation status of SOD1, SOD2, GPx1, GPx4, CAT, NOS1 and NOS2 in the brain and blood of rats exposed to a chronic mild stress (CMS) model of depression. Serotonin 68-77 nitric oxide synthase 1 Rattus norvegicus 199-203 31981722-0 2020 Serotonin induces Arcadlin in hippocampal neurons. Serotonin 0-9 protocadherin 8 Homo sapiens 18-26 29520369-1 2018 Expression of TPH2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the dorsal raphe nucleus (DR) of depressed suicide victims. Serotonin 55-64 tryptophan hydroxylase 2 Rattus norvegicus 14-18 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase A Homo sapiens 112-117 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase A Homo sapiens 112-117 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 149-168 monoamine oxidase A Homo sapiens 7-12 32119710-1 2020 The tryptophan hydroxylase 2 (TPH2) enzyme catalyzes the first step of serotonin biosynthesis. Serotonin 71-80 tryptophan hydroxylase 2 Homo sapiens 4-28 32119710-1 2020 The tryptophan hydroxylase 2 (TPH2) enzyme catalyzes the first step of serotonin biosynthesis. Serotonin 71-80 tryptophan hydroxylase 2 Homo sapiens 30-34 11277522-2 2001 This new compound 1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine (2) was found to be a potent serotonin 5-HT1A agonist. Serotonin 91-100 5-hydroxytryptamine receptor 1A Homo sapiens 101-107 32119710-3 2020 As the reaction catalyzed by TPH2 is the rate-limiting step of serotonin biosynthesis, mutations in TPH2 have been associated with several psychiatric disorders (PD). Serotonin 63-72 tryptophan hydroxylase 2 Homo sapiens 29-33 32119710-3 2020 As the reaction catalyzed by TPH2 is the rate-limiting step of serotonin biosynthesis, mutations in TPH2 have been associated with several psychiatric disorders (PD). Serotonin 63-72 tryptophan hydroxylase 2 Homo sapiens 100-104 11284452-2 2001 Pharmacological evidence obtained in rodents suggests that terminal and somatodendritic autoreceptors controlling serotonin (5-hydroxytryptamine, 5-HT) release belong to the 5-HT1B/D subtype of receptors, whereas somatodendritic autoreceptors controlling neuronal cell firing are predominantly of the 5-HT1A subtype. Serotonin 114-123 5-hydroxytryptamine receptor 1A Homo sapiens 301-307 31935571-10 2020 In addition, exposure to AS increased the plasma level of cortisol and down-regulated the mRNA expression levels of genes involved in 5-HT synthesis (such as tph1b and pet1) in both control and TBT-treated fish. Serotonin 134-138 tryptophan hydroxylase 1b Danio rerio 158-163 11207028-0 2001 Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline. Serotonin 55-74 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 14-33 31571657-7 2020 Using dual immunolabeling for Fos protein, a marker for neuronal activity, and serotonin (5-hydroxytrypamine; 5-HT), numbers of Fos-positive 5-HT neurons were determined in five dorsal raphe nuclei. Serotonin 141-145 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 128-131 31571657-8 2020 We found that restraint stress alone increased numbers of Fos-positive 5-HT neurons in all five dorsal raphe nuclei compared to control animals. Serotonin 71-75 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 58-61 31571657-9 2020 However, following P3 HI, the number of stress-induced Fos-positive 5-HT neurons was decreased significantly in the dorsal raphe ventrolateral, interfascicular and ventral nuclei compared with control animals exposed to restraint stress. Serotonin 68-72 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 55-58 31571657-10 2020 In contrast, numbers of stress-induced Fos-positive 5-HT neurons in the dorsal raphe dorsal and caudal nuclei were not affected by P3 HI. Serotonin 52-56 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 39-42 11160454-4 2001 A postmortem brain analysis revealed that both dopamine and serotonin metabolism were increased in the frontal cortex and striatum of GluRepsilon1 mutant mice. Serotonin 60-69 glutamate receptor, ionotropic, NMDA2A (epsilon 1) Mus musculus 134-146 32085796-10 2020 Tegaserod (TM) is a serotonin receptor 4 agonist (HTR4) used in the treatment of irritable bowel syndrome (IBS). Serotonin 20-29 5-hydroxytryptamine receptor 4 Homo sapiens 50-54 11667949-0 2001 Inability of serotonin to activate the c-Jun N-terminal kinase and p38 kinase pathways in rat aortic vascular smooth muscle cells. Serotonin 13-22 mitogen-activated protein kinase 8 Rattus norvegicus 39-62 11752890-2 2001 IL-1 and LPS are known to affect cerebral neurotransmission involving norepinephrine and serotonin, both of which have been implicated in feeding behavior and in the pharmacotherapy of depression in man. Serotonin 89-98 interleukin 1 alpha Homo sapiens 0-4 32047194-8 2020 NaV1.8-/- impaired histamine and 5-HT-induced scratching while NaV1.9 was involved in itch signalling towards 5-HT, C48/80 and SLIGRL. Serotonin 110-114 sodium channel, voltage-gated, type XI, alpha Mus musculus 63-69 31882369-1 2020 The serotonin 5-HT7 G protein-coupled receptor (GPCR) is a proposed pharmacotherapeutic target for a variety of central and peripheral indications, albeit, there are no approved drugs selective for binding 5-HT7. Serotonin 4-13 atypical chemokine receptor 3 Homo sapiens 20-46 31882369-1 2020 The serotonin 5-HT7 G protein-coupled receptor (GPCR) is a proposed pharmacotherapeutic target for a variety of central and peripheral indications, albeit, there are no approved drugs selective for binding 5-HT7. Serotonin 4-13 atypical chemokine receptor 3 Homo sapiens 48-52 31882369-1 2020 The serotonin 5-HT7 G protein-coupled receptor (GPCR) is a proposed pharmacotherapeutic target for a variety of central and peripheral indications, albeit, there are no approved drugs selective for binding 5-HT7. Serotonin 4-13 basigin Mus musculus 16-19 11067904-4 2000 Moreover, OVA sensitization/aerosol challenge of wild-type and mMBP-1(-/-) mice resulted in identical dose-response changes to either methacholine or serotonin. Serotonin 150-159 proteoglycan 2, bone marrow Mus musculus 63-69 31806625-3 2020 Here, we report that serotonin regulates beta-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. Serotonin 21-30 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 73-94 31875487-5 2020 We found that 5-HT reduces GABAA IPSCs via presynaptic 5-HT1B receptors. Serotonin 14-18 5-hydroxytryptamine receptor 1B Rattus norvegicus 55-61 11053216-5 2000 Radioligand binding assays using either [(3)H]-5-CT or [(3)H]-GR125743 on Cos-7 cell membranes showed that pK(i) values of 14 serotonin ligands were highly correlated with those obtained with the human 5-HT(1D) receptor. Serotonin 126-135 5-hydroxytryptamine receptor 1D Cavia porcellus 202-219 31905199-5 2020 NSC proliferation was suppressed by serotonin via down-regulation of brain-derived neurotrophic factor (BDNF)-expression in serotonin-responsive periventricular neurons. Serotonin 36-45 brain derived neurotrophic factor Homo sapiens 104-108 31905199-5 2020 NSC proliferation was suppressed by serotonin via down-regulation of brain-derived neurotrophic factor (BDNF)-expression in serotonin-responsive periventricular neurons. Serotonin 124-133 brain derived neurotrophic factor Homo sapiens 104-108 31914916-8 2020 Moreover, CORT+ FPR2/3 KO and ANXA1 KO, exhibited an higher expression of brain derived neurotrophic factor (BDNF), phospho-ERK, cAMP response element-binding protein (pCREB) and a decrease of serotonin transporter expression (SERT) compared to WT(CORT+) mice. Serotonin 193-202 cortistatin Mus musculus 10-14 10936212-2 2000 Serotonin, (R)-8-hydroxy-2-dipropylaminotetralin [(R)-8-OH-DPAT], and buspirone inhibited cyclic AMP production in cells expressing native and mutant 5-HT(1A) receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 150-157 31914916-8 2020 Moreover, CORT+ FPR2/3 KO and ANXA1 KO, exhibited an higher expression of brain derived neurotrophic factor (BDNF), phospho-ERK, cAMP response element-binding protein (pCREB) and a decrease of serotonin transporter expression (SERT) compared to WT(CORT+) mice. Serotonin 193-202 formyl peptide receptor 2 Mus musculus 16-20 10936212-3 2000 Serotonin, however, produced inverse bell-shaped cyclic AMP concentration-response curves at native and mutant 5-HT(1A) receptors, indicating coupling not only to G(i)/G(o), but also to G(s). Serotonin 0-9 5-hydroxytryptamine receptor 1A Homo sapiens 111-118 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase A Homo sapiens 19-24 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase A Homo sapiens 26-31 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase A Homo sapiens 26-31 11081224-2 2000 Results of the biochemical analysis of the MAO A activity with serotonin or noradrenaline as substrates revealed a seasonal dependence of the substrate specific changes of this enzyme activity in hibernating animals. Serotonin 63-72 monoamine oxidase A Homo sapiens 43-48 31977880-1 2020 Human serotonin receptor 4 (HTR4) encodes a 5-HT4 receptor involved in learning, memory, depression, anxiety, and feeding behavior. Serotonin 6-15 5-hydroxytryptamine receptor 4 Homo sapiens 28-32 10928397-11 2000 It has been hypothesized that serotonin (5-HT1A) antagonism may decrease the responsiveness of the pancreatic beta-cells. Serotonin 30-39 5-hydroxytryptamine receptor 1A Homo sapiens 41-47 31863005-3 2019 Based on these and other observations, we hypothesized that serotonin (5-HT)-dependent activation of spinal CXC Motif Chemokine Receptor 2 (CXCR2) may support TBI-related nociceptive sensitization in a mouse model of mild TBI (mTBI). Serotonin 60-69 chemokine (C-X-C motif) receptor 2 Mus musculus 108-138 31863005-3 2019 Based on these and other observations, we hypothesized that serotonin (5-HT)-dependent activation of spinal CXC Motif Chemokine Receptor 2 (CXCR2) may support TBI-related nociceptive sensitization in a mouse model of mild TBI (mTBI). Serotonin 60-69 chemokine (C-X-C motif) receptor 2 Mus musculus 140-145 31863005-3 2019 Based on these and other observations, we hypothesized that serotonin (5-HT)-dependent activation of spinal CXC Motif Chemokine Receptor 2 (CXCR2) may support TBI-related nociceptive sensitization in a mouse model of mild TBI (mTBI). Serotonin 71-75 chemokine (C-X-C motif) receptor 2 Mus musculus 108-138 31863005-3 2019 Based on these and other observations, we hypothesized that serotonin (5-HT)-dependent activation of spinal CXC Motif Chemokine Receptor 2 (CXCR2) may support TBI-related nociceptive sensitization in a mouse model of mild TBI (mTBI). Serotonin 71-75 chemokine (C-X-C motif) receptor 2 Mus musculus 140-145 30326484-3 2018 The proinflammatory cytokine IL-18, with a recognized role in brain functions, may influence serotonin metabolism and appears to be associated with alexithymia. Serotonin 93-102 interleukin 18 Homo sapiens 29-34 31699607-1 2019 A series of novel alkoxy-piperidine derivatives were synthesized and evaluated for their serotonin reuptake inhibitory and binding affinities for 5-HT1A/5-HT7 receptors. Serotonin 89-98 basigin Mus musculus 155-158 12404310-2 2000 Much of the evidence for the role of serotonin (5-HT) in these disorders comes from treatment studies with serotonergic drugs, including selective serotonin reuptake inhibitors (SSRIs), 5-HT(1A) agonists and 5-HT antagonists. Serotonin 37-46 5-hydroxytryptamine receptor 1A Homo sapiens 186-193 31606593-4 2019 Additionally, while BDNF is strongly regulated by serotonin levels and inherited serotonin transporter down-regulation is associated with increased vulnerability to cocaine addiction, the effects of serotonin transporter genotype on BDNF signaling in the amygdala under naive and cocaine exposure conditions are unknown. Serotonin 50-59 brain-derived neurotrophic factor Rattus norvegicus 20-24 28844871-4 2017 We have previously demonstrated that central soluble beta amyloid 1-42 (Abeta) administration peptide induces a depressive like-behavior in rats, with altered HPA axis activation, reduced cortical serotonin and neurotrophin levels. Serotonin 197-206 amyloid beta precursor protein Rattus norvegicus 72-77 10862804-1 2000 BACKGROUND: The ability of pindolol to block 5-HT(1A) autoreceptors on serotonin-containing neurons in the raphe nuclei is thought to underlie the clinical reports of enhanced efficacy and rate of improvement in depressed patients treated with pindolol/selective serotonin reuptake inhibitor (SSRI) combinations. Serotonin 71-80 5-hydroxytryptamine receptor 1A Homo sapiens 45-52 10837296-0 2000 The bovine protein alpha-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brain serotonin activity, reduces cortisol concentration, and improves mood under stress. Serotonin 158-167 lactalbumin alpha Bos taurus 19-36 31582824-1 2019 Head-twitch behavior (HTR) is the behavioral signature of psychedelic drugs upon stimulation of the serotonin 5-HT2A receptor (5-HT2AR) in rodents. Serotonin 100-109 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 127-134 31322231-2 2019 It has been reported that selective serotonin reuptake inhibitors promote the expression of tryptophan hydroxylase (TPH), which is involved in the synthesis of serotonin. Serotonin 36-45 tryptophan hydroxylase 1 Rattus norvegicus 92-114 10783401-9 2000 These studies provide novel, suggestive evidence that BDNF and NT-3, possibly through their trophic effects on serotonergic neurons and/or motoneurons, may underlie serotonin-dependent plasticity in (spinal) respiratory motor control after CDR. Serotonin 165-174 neurotrophin 3 Rattus norvegicus 63-67 31322231-2 2019 It has been reported that selective serotonin reuptake inhibitors promote the expression of tryptophan hydroxylase (TPH), which is involved in the synthesis of serotonin. Serotonin 36-45 tryptophan hydroxylase 1 Rattus norvegicus 116-119 31322231-2 2019 It has been reported that selective serotonin reuptake inhibitors promote the expression of tryptophan hydroxylase (TPH), which is involved in the synthesis of serotonin. Serotonin 160-169 tryptophan hydroxylase 1 Rattus norvegicus 92-114 31322231-2 2019 It has been reported that selective serotonin reuptake inhibitors promote the expression of tryptophan hydroxylase (TPH), which is involved in the synthesis of serotonin. Serotonin 160-169 tryptophan hydroxylase 1 Rattus norvegicus 116-119 31322231-3 2019 However, limited evidence of TPH alteration has been found in selective serotonin and noradrenaline reuptake inhibitors (SNRIs), and more key enzymes need to be investigated. Serotonin 72-81 tryptophan hydroxylase 1 Rattus norvegicus 29-32 10727532-5 2000 Similar results were obtained with serotonin receptor 5-hydroxytryptamine(2C), which is coupled to Galphaq. Serotonin 54-73 G protein subunit alpha q Homo sapiens 99-106 30977636-0 2019 Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. Serotonin 31-40 tryptophan hydroxylase 2 Rattus norvegicus 69-93 30977636-1 2019 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT). Serotonin 103-112 tryptophan hydroxylase 1 Rattus norvegicus 0-22 30977636-1 2019 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT). Serotonin 103-112 tryptophan hydroxylase 1 Rattus norvegicus 24-27 30977636-1 2019 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT). Serotonin 114-133 tryptophan hydroxylase 1 Rattus norvegicus 0-22 30977636-1 2019 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT). Serotonin 114-133 tryptophan hydroxylase 1 Rattus norvegicus 24-27 30977636-1 2019 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT). Serotonin 135-139 tryptophan hydroxylase 1 Rattus norvegicus 0-22 30977636-1 2019 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of the biogenic monoamine serotonin (5-hydroxytryptamine, 5-HT). Serotonin 135-139 tryptophan hydroxylase 1 Rattus norvegicus 24-27 11125474-7 2000 C5a activates local mast cells to release serotonin (5-HT) and TNF alpha to induce endothelial ICAM-1 and VCAM-1, leading to T cell recruitment. Serotonin 42-51 vascular cell adhesion molecule 1 Mus musculus 106-112 30977636-3 2019 TPH1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-HT biosynthesis in non-neuronal tissues, while TPH2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-HT in the brain. Serotonin 87-91 tryptophan hydroxylase 1 Rattus norvegicus 0-4 30977636-3 2019 TPH1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-HT biosynthesis in non-neuronal tissues, while TPH2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-HT in the brain. Serotonin 231-235 tryptophan hydroxylase 1 Rattus norvegicus 0-4 30977636-3 2019 TPH1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-HT biosynthesis in non-neuronal tissues, while TPH2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-HT in the brain. Serotonin 231-235 tryptophan hydroxylase 2 Rattus norvegicus 136-140 10647887-7 1999 The uVNTR genotype may be a common genetic determinant of significant individual differences in oxidizing capacity for critical MAO-A substrates, which include serotonin, norepinephrine, and tyramine. Serotonin 160-169 monoamine oxidase A Homo sapiens 128-133 31078489-3 2019 The present study showed that tryptophan hydroxylase 2 (Tph2) knockout (KO) rats, which exhibit profoundly diminished extracellular serotonin levels, display increased aggressiveness compared to their Tph2 wildtype (WT) counterparts. Serotonin 132-141 tryptophan hydroxylase 2 Rattus norvegicus 30-54 31078489-3 2019 The present study showed that tryptophan hydroxylase 2 (Tph2) knockout (KO) rats, which exhibit profoundly diminished extracellular serotonin levels, display increased aggressiveness compared to their Tph2 wildtype (WT) counterparts. Serotonin 132-141 tryptophan hydroxylase 2 Rattus norvegicus 56-60 10582616-0 1999 Vesicular monoamine transporter 1 is responsible for storage of 5-hydroxytryptamine in rat pinealocytes. Serotonin 64-83 solute carrier family 18 member A1 Rattus norvegicus 0-33 31456825-3 2019 Brain-Derived Neurotrophic Factor (BDNF) plays a role in maintaining the survival of neuronal cells and in the regulation of synapse plasticity, affecting serotonin production in the hippocampus and thus the depressive symptoms. Serotonin 155-164 brain derived neurotrophic factor Homo sapiens 0-33 31456825-3 2019 Brain-Derived Neurotrophic Factor (BDNF) plays a role in maintaining the survival of neuronal cells and in the regulation of synapse plasticity, affecting serotonin production in the hippocampus and thus the depressive symptoms. Serotonin 155-164 brain derived neurotrophic factor Homo sapiens 35-39 10582619-2 1999 GTP-CH catalyses the first step in the biosynthesis of tetrahydrobiopterin (BH4), a cofactor necessary for the synthesis of catecholamines and serotonin. Serotonin 143-152 GTP cyclohydrolase 1 Mus musculus 0-6 10557342-0 1999 Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons. Serotonin 60-69 carbonic anhydrase 1 Rattus norvegicus 99-102 31017740-8 2019 We show the expression of two serotonin synthesizing enzymes, tryptophan hydroxylase 1a and 1b in the blastema, suggesting the local production of this monoamine. Serotonin 30-39 tryptophan hydroxylase 1b Danio rerio 62-94 10557342-4 1999 Rats were injected daily for 3 weeks with a high dose of corticosterone; electrophysiological responses to serotonin were recorded intracellularly from CA1 pyramidal neurons in vitro. Serotonin 107-116 carbonic anhydrase 1 Rattus norvegicus 152-155 30578843-7 2019 Evaluation of metabolic and behavioral response to the pharmacotherapy with these antipsychotics demonstrates an important unbalance in serotonin pathway in both nud-1 and nud-2 knockout worms, with more significant effects for nud-2 knockout. Serotonin 136-145 Protein nud-2 Caenorhabditis elegans 172-177 10527123-6 1999 Serotonin agonist quipazine increased GH levels but failed to enhance the stimulatory effect of melatonin. Serotonin 0-9 somatotropin Coturnix japonica 38-40 10511003-11 1999 In addition, both TTX and the gamma-amino-N-butyric acid (GABA) receptor blocker bicuculline inhibited the 5HT-induced Ca2+ transients. Serotonin 107-110 GABA type A receptor-associated protein Homo sapiens 30-72 31008593-6 2019 Milk yield increased by Trp was linked to 5-hydroxytryptamine-mediated synthesis of FAS, LS, and beta-casein in PMECs, while the increase in calcium concentration was attributed to increasing CaM expression and CAMKII activity. Serotonin 42-61 fatty acid synthase Homo sapiens 84-87 30689993-2 2019 For example, activation of serotonin 5-HT2C GPCRs is pharmacotherapeutic for obesity, but there is tolerance to the anorectic effect of the only approved 5-HT2C agonist, lorcaserin. Serotonin 27-36 5-hydroxytryptamine receptor 2C Homo sapiens 37-43 10504491-9 1999 MAO activity measured in intact cells showed that after accumulation into mesangial cells, [14C]serotonin was metabolized by MAO-A. Serotonin 96-105 monoamine oxidase A Homo sapiens 125-130 30808545-7 2019 We confirmed that miR-26a-2 downregulates Htr1a expression in 5-HT neurons in vitro. Serotonin 62-66 microRNA 26a-2 Mus musculus 18-27 10502659-4 1999 Serotonin (10-9-10-5 M) caused a concentration-related vasoconstriction in renal arcuate arteries which was shifted to the right in the time control study (P < 0.001) but this was abolished by both 0.1 and 20 U ml-1 of EPO. Serotonin 0-9 erythropoietin Rattus norvegicus 222-225 30169377-6 2019 The observed pattern of c-Fos expression suggests that the first exposure to the maze activates serotonin cells in the rostral and dorsal regions of the DRN and that only the dorsal subregion is activated by a second exposure. Serotonin 96-105 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 24-29 10495272-5 1999 The peak of serotonin synthesis at the beginning of germband extension appears strictly dependent upon the maternal deposition of biopterins, products of GTP-cyclohydrolase and cofactors of tryptophan hydroxylase and upon the zygotic synthesis of both tryptophan hydroxylase and DOPA decarboxylase enzymes. Serotonin 12-21 Tryptophan hydroxylase Drosophila melanogaster 190-212 30713268-1 2019 Serotonin (5-hydroxytryptamine; 5-HT) can induce hepatocyte DNA synthesis and proliferation by autocrine secretion of transforming growth factor (TGF)-alpha through 5-HT2B receptor/phospholipase C (PLC)/Ca2+ and a signaling pathway involving epidermal growth factor (EGF)/TGF-alpha receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase 2 (ERK2)/mammalian target of rapamycin (mTOR). Serotonin 0-9 transforming growth factor alpha Rattus norvegicus 272-281 30713268-1 2019 Serotonin (5-hydroxytryptamine; 5-HT) can induce hepatocyte DNA synthesis and proliferation by autocrine secretion of transforming growth factor (TGF)-alpha through 5-HT2B receptor/phospholipase C (PLC)/Ca2+ and a signaling pathway involving epidermal growth factor (EGF)/TGF-alpha receptor tyrosine kinase (RTK)/extracellular signal-regulated kinase 2 (ERK2)/mammalian target of rapamycin (mTOR). Serotonin 11-30 transforming growth factor alpha Rattus norvegicus 272-281 10495272-5 1999 The peak of serotonin synthesis at the beginning of germband extension appears strictly dependent upon the maternal deposition of biopterins, products of GTP-cyclohydrolase and cofactors of tryptophan hydroxylase and upon the zygotic synthesis of both tryptophan hydroxylase and DOPA decarboxylase enzymes. Serotonin 12-21 Tryptophan hydroxylase Drosophila melanogaster 252-274 10485589-8 1999 It is proposed that interactions between IL-6 and brain serotonin is a complex process which involves corticotropin-releasing factor (CRF) and opioid peptides. Serotonin 56-65 corticotropin releasing hormone Homo sapiens 102-132 10451024-2 1999 This enzyme converts serotonin to N-acetylserotonin by the transfer of an acetyl group from acetyl coenzyme A. Endogenous AA-NAT instability during routine purification has made enzyme characterization difficult, but now a stable recombinant protein for AA-NAT has been synthesized to investigate the intrinsic biochemical properties of AA-NAT from a rat pineal cDNA encoding a 205 amino acid, 23 kilodalton protein, by using a glutathione-S-transferase (GST) fusion protein system. Serotonin 21-30 aralkylamine N-acetyltransferase Rattus norvegicus 122-128 30610839-1 2019 Mephedrone (4-methyl-N-methylcathinone) is a psychostimulant that promotes release of monoamines via the high affinity transporters for dopamine (DAT), norepinephrine (NET) and serotonin (SERT). Serotonin 177-186 solute carrier family 6 member 3 Homo sapiens 146-149 30712943-7 2019 These results suggest that Cdk5-p35 modulates 5-HT signaling through phosphorylation-dependent degradation of 5-HTlAR. Serotonin 46-50 cyclin dependent kinase 5 regulatory subunit 1 Homo sapiens 32-35 10451024-2 1999 This enzyme converts serotonin to N-acetylserotonin by the transfer of an acetyl group from acetyl coenzyme A. Endogenous AA-NAT instability during routine purification has made enzyme characterization difficult, but now a stable recombinant protein for AA-NAT has been synthesized to investigate the intrinsic biochemical properties of AA-NAT from a rat pineal cDNA encoding a 205 amino acid, 23 kilodalton protein, by using a glutathione-S-transferase (GST) fusion protein system. Serotonin 21-30 aralkylamine N-acetyltransferase Rattus norvegicus 254-260 10451024-2 1999 This enzyme converts serotonin to N-acetylserotonin by the transfer of an acetyl group from acetyl coenzyme A. Endogenous AA-NAT instability during routine purification has made enzyme characterization difficult, but now a stable recombinant protein for AA-NAT has been synthesized to investigate the intrinsic biochemical properties of AA-NAT from a rat pineal cDNA encoding a 205 amino acid, 23 kilodalton protein, by using a glutathione-S-transferase (GST) fusion protein system. Serotonin 21-30 aralkylamine N-acetyltransferase Rattus norvegicus 254-260 10432488-4 1999 Recent evidence suggests that serotonin can enhance the production of new neurons via activation of the 5HT1A receptor. Serotonin 30-39 5-hydroxytryptamine receptor 1A Homo sapiens 104-118 10366650-3 1999 We demonstrate that virtually all neurons in the caudal raphe nuclei that express GATA-3 also produce serotonin. Serotonin 102-111 GATA binding protein 3 Mus musculus 82-88 28687902-8 2017 It was also observed that SAS increased the availability of tryptophan in blood and brain and hence increases 5-hydroxytryptamine (Serotonin: 5HT) in the brain. Serotonin 110-129 methionine adenosyltransferase 1A Rattus norvegicus 26-29 28687902-8 2017 It was also observed that SAS increased the availability of tryptophan in blood and brain and hence increases 5-hydroxytryptamine (Serotonin: 5HT) in the brain. Serotonin 131-140 methionine adenosyltransferase 1A Rattus norvegicus 26-29 28687902-8 2017 It was also observed that SAS increased the availability of tryptophan in blood and brain and hence increases 5-hydroxytryptamine (Serotonin: 5HT) in the brain. Serotonin 142-145 methionine adenosyltransferase 1A Rattus norvegicus 26-29 10431754-0 1999 Actions of roxindole at recombinant human dopamine D2, D3 and D4 and serotonin 5-HT1A, 5-HT1B and 5-HT1D receptors. Serotonin 69-78 5-hydroxytryptamine receptor 1A Homo sapiens 79-85 28687902-9 2017 At the end, it was concluded that SAS contains some active principles which increase the availability of neurochemical (tryptophan and 5HT) and decrease the 5HT turnover rate thus causes antidepressant and anxiolytic effects in experimental animals. Serotonin 135-138 methionine adenosyltransferase 1A Rattus norvegicus 34-37 28687902-9 2017 At the end, it was concluded that SAS contains some active principles which increase the availability of neurochemical (tryptophan and 5HT) and decrease the 5HT turnover rate thus causes antidepressant and anxiolytic effects in experimental animals. Serotonin 157-160 methionine adenosyltransferase 1A Rattus norvegicus 34-37 10385247-7 1999 Mutations of threonine 100 and arginine 102 at the extracellular side of transmembrane II of the guinea-pig 5-HT1D receptor to the corresponding primate residues, isoleucine and histidine, respectively, enhanced its affinity for isochromans to that of the gorilla receptor, with little effects on its affinities for serotonin, sumatriptan and metergoline. Serotonin 316-325 5-hydroxytryptamine receptor 1D Cavia porcellus 108-123 29038237-0 2017 The Gain-of-Function Integrin beta3 Pro33 Variant Alters the Serotonin System in the Mouse Brain. Serotonin 61-70 integrin beta 3 Mus musculus 21-35 29038237-2 2017 Multiple lines of evidence link the ITGB3 gene encoding the integrin beta3 subunit with the serotonin (5-HT) system, likely via its modulation of the 5-HT transporter (SERT). Serotonin 92-101 integrin beta 3 Mus musculus 36-41 10385247-10 1999 For G protein-coupling, serotonin marginally enhanced GTPgamma35S binding in membranes expressing the guinea-pig 5-HT1D receptor and its mutants, but robustly in membranes expressing the gorilla receptor. Serotonin 24-33 5-hydroxytryptamine receptor 1D Cavia porcellus 113-128 29038237-2 2017 Multiple lines of evidence link the ITGB3 gene encoding the integrin beta3 subunit with the serotonin (5-HT) system, likely via its modulation of the 5-HT transporter (SERT). Serotonin 92-101 integrin beta 3 Mus musculus 60-74 10220583-0 1999 Serotonin derivative, N-(p-Coumaroyl)serotonin, isolated from safflower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibroblasts in synergy with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). Serotonin 0-9 epidermal growth factor Mus musculus 229-252 10220583-0 1999 Serotonin derivative, N-(p-Coumaroyl)serotonin, isolated from safflower (Carthamus tinctorius L.) oil cake augments the proliferation of normal human and mouse fibroblasts in synergy with basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). Serotonin 0-9 epidermal growth factor Mus musculus 254-257 10340308-3 1999 The P2X1-7 active P2 purinoceptor agonist, 2-methylthioATP (2-MeSATP: 100 microM) increased the extracellular serotonin level drastically (638%), while the P2X1,3 active P2 purinoceptor agonist, alpha, beta-methylene-L-ATP (alpha, beta-meATP: 100 microM) produced a small increase (132%) in the serotonin level. Serotonin 295-304 purinergic receptor P2X 1 Homo sapiens 4-10 28757258-1 2017 In addition to its role in neuronal survival, the brain neurotrophic factor (BDNF) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of l-DOPA-induced dyskinesia (LID), a motor complication occurring in parkinsonian patients after long-term treatment with the dopamine precursor. Serotonin 111-120 neurotrophin 3 Homo sapiens 56-75 28757258-1 2017 In addition to its role in neuronal survival, the brain neurotrophic factor (BDNF) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of l-DOPA-induced dyskinesia (LID), a motor complication occurring in parkinsonian patients after long-term treatment with the dopamine precursor. Serotonin 111-120 brain derived neurotrophic factor Homo sapiens 77-81 10340308-3 1999 The P2X1-7 active P2 purinoceptor agonist, 2-methylthioATP (2-MeSATP: 100 microM) increased the extracellular serotonin level drastically (638%), while the P2X1,3 active P2 purinoceptor agonist, alpha, beta-methylene-L-ATP (alpha, beta-meATP: 100 microM) produced a small increase (132%) in the serotonin level. Serotonin 295-304 pyrimidinergic receptor P2Y6 Homo sapiens 18-33 28757258-5 2017 Results showed that the AAV-BDNF vector injection induced striatal over-expression of BDNF, as well as striatal and pallidal serotonin axon hyperinnervation. Serotonin 125-134 brain-derived neurotrophic factor Rattus norvegicus 28-32 10340308-3 1999 The P2X1-7 active P2 purinoceptor agonist, 2-methylthioATP (2-MeSATP: 100 microM) increased the extracellular serotonin level drastically (638%), while the P2X1,3 active P2 purinoceptor agonist, alpha, beta-methylene-L-ATP (alpha, beta-meATP: 100 microM) produced a small increase (132%) in the serotonin level. Serotonin 295-304 purinergic receptor P2X 1 Homo sapiens 156-162 10340308-4 1999 The P2X1,2,3,5,7 active P2 purinoceptor antagonist, suramin (100 microM), reduced the basal serotonin level (86%) and the ATP-evoked initial rise phase (from 309 to 254%) without affecting the late reduction phase. Serotonin 92-101 purinergic receptor P2X 1 Homo sapiens 4-8 28849191-6 2017 PHC normalized CUMS-induced disorders of dihydroxyphenylacetic acid, dopamine, 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid in serum and/or hypothalamus of depression-like rats. Serotonin 79-98 solute carrier family 25 member 3 Rattus norvegicus 0-3 28849191-6 2017 PHC normalized CUMS-induced disorders of dihydroxyphenylacetic acid, dopamine, 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid in serum and/or hypothalamus of depression-like rats. Serotonin 100-104 solute carrier family 25 member 3 Rattus norvegicus 0-3 10340308-4 1999 The P2X1,2,3,5,7 active P2 purinoceptor antagonist, suramin (100 microM), reduced the basal serotonin level (86%) and the ATP-evoked initial rise phase (from 309 to 254%) without affecting the late reduction phase. Serotonin 92-101 pyrimidinergic receptor P2Y6 Homo sapiens 24-39 28751217-3 2017 Moreover, it is not known if the two tryptophan hydroxylase isoforms (TPH1 and TPH2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. Serotonin 115-124 tryptophan hydroxylase 2 Homo sapiens 79-83 28751217-10 2017 This study demonstrates that both TPH1 and TPH2 are expressed in human and mouse placenta throughout pregnancy and helps to better understand the placental serotonin system, which is crucial for healthy pregnancy and fetal development. Serotonin 156-165 tryptophan hydroxylase 2 Homo sapiens 43-47 10390727-2 1999 Serotonin has been implicated as a mediator involved in migraine headache, an effect that may involve central 5-HT2B receptor activation. Serotonin 0-9 5-hydroxytryptamine receptor 2B Rattus norvegicus 110-116 28655604-3 2017 Melatonin is synthesized from serotonin through two enzymes, the first limiting step into the synthesis of melatonin being aralkylamine N-acetyltransferase (AANAT). Serotonin 30-39 aralkylamine N-acetyltransferase Homo sapiens 123-155 28655604-3 2017 Melatonin is synthesized from serotonin through two enzymes, the first limiting step into the synthesis of melatonin being aralkylamine N-acetyltransferase (AANAT). Serotonin 30-39 aralkylamine N-acetyltransferase Homo sapiens 157-162 10390727-5 1999 Rat stomach fundus contraction to serotonin has been used as a model for 5-HT2B receptor activation. Serotonin 34-43 5-hydroxytryptamine receptor 2B Rattus norvegicus 73-79 28729116-2 2017 It is known that different classes of ADs affects the GR action via modifying its phosphorylation, while the mechanism through which ADs alter GR phosphorylation targeted by GSK3beta, a kinase modulated via serotonin neurotransmission, are unclear. Serotonin 207-216 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 54-56 28729116-2 2017 It is known that different classes of ADs affects the GR action via modifying its phosphorylation, while the mechanism through which ADs alter GR phosphorylation targeted by GSK3beta, a kinase modulated via serotonin neurotransmission, are unclear. Serotonin 207-216 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 143-145 10231022-4 1999 The synergistic interaction of 5-HT (1-5 microM) and epinephrine (0.5-2 microM) was inhibited by alpha2-adrenoceptor blocker (yohimbine; IC50= 0.4 microM), calcium channel blockers (verapamil and diltiazem with IC50 of 10 and 48 mM, respectively), PLC inhibitor (U73122; IC50=6 microM) and nitric oxide (NO) donor, SNAP (IC50=1.6 microM)). Serotonin 31-35 heparan sulfate proteoglycan 2 Homo sapiens 248-251 28811310-4 2017 Here, we find that regulatory sequences of tph1b, which encodes an enzyme that synthesizes serotonin, mark a subpopulation of fibroblast-like cells restricted to the joints of uninjured adult zebrafish fins. Serotonin 91-100 tryptophan hydroxylase 1b Danio rerio 43-48 9988712-2 1999 The Gi-coupled serotonin (5-hydroxytryptamine (5-HT)) 5-HT1A receptor, heterologously expressed in Chinese hamster ovary or human embryonic kidney 293 cells, mediated rapid activation of Erk1/2 via a mechanism dependent upon both Ras activation and clathrin-mediated endocytosis. Serotonin 26-45 5-hydroxytryptamine receptor 1A Homo sapiens 54-69 28343167-4 2017 The strategic location of CCK(1)r in mesolimbic structures and specific hypothalamic and brainstem nuclei lead to complex interactions with neurotransmitters like dopamine, serotonin, and glutamate, as well as hypothalamic hormones and neuropeptides. Serotonin 173-182 cholecystokinin A receptor Homo sapiens 26-33 28343167-5 2017 The activity of CCK(1)r maintains adequate levels of dopamine and regulates the activity of serotonin neurons of raphe nuclei, which makes CCK(1)r an interesting therapeutic target for the development of adjuvant treatments for schizophrenia, drug addiction, and mood disorders. Serotonin 92-101 cholecystokinin A receptor Homo sapiens 16-23 10636468-1 1999 Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step in the biosynthesis of serotonin. Serotonin 85-94 tryptophan 5-hydroxylase 1 Oryctolagus cuniculus 0-22 28343167-5 2017 The activity of CCK(1)r maintains adequate levels of dopamine and regulates the activity of serotonin neurons of raphe nuclei, which makes CCK(1)r an interesting therapeutic target for the development of adjuvant treatments for schizophrenia, drug addiction, and mood disorders. Serotonin 92-101 cholecystokinin A receptor Homo sapiens 139-146 28461009-0 2017 Reduced Vesicular Acetylcholine Transporter favors antidepressant behaviors and modulates serotonin and dopamine in female mouse brain. Serotonin 90-99 solute carrier family 18 (vesicular monoamine), member 3 Mus musculus 8-43 10636468-1 1999 Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step in the biosynthesis of serotonin. Serotonin 85-94 tryptophan 5-hydroxylase 1 Oryctolagus cuniculus 24-27 10446735-5 1999 The rapid increase in serotonin (5-HT) synaptic levels by blockade of alpha2-heteroreceptors indirectly enhances 5-HT1A-mediated neurotransmission since 5-HT2 and 5-HT3 are blocked by mirtazapine. Serotonin 22-31 5-hydroxytryptamine receptor 1A Homo sapiens 113-119 28336394-0 2017 Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism. Serotonin 172-181 Trichinella spiralis resistance 1 Mus musculus 0-3 28336394-6 2017 Furthermore, Ts1Cje mice showed monoamine abnormalities, including increased extracellular dopamine and serotonin, and enhanced catabolism in the striatum and ventral forebrain. Serotonin 104-113 reciprocal translocation, Chr 12 and 16, Epstein 1 Mus musculus 13-19 28103616-1 2017 In the normal human adrenal gland, serotonin (5-HT) stimulates aldosterone secretion through the 5-HT4 receptor (5-HT4R). Serotonin 35-44 5-hydroxytryptamine receptor 4 Homo sapiens 97-111 30700110-10 2019 CONCLUSIONS: Findings provide preliminary evidence for genes potentially important in cortisol response to an acute stressor in children in the serotonin, dopamine, and brain-derived neurotrophic factor pathways, the hypothalamic-pituitary-adrenal axis, and the inflammatory response. Serotonin 144-153 brain derived neurotrophic factor Homo sapiens 169-202 30552180-10 2019 FosB+ cells were reduced in entorhinal cortex and hippocampus (CA2/3) and increased in dorsal raphe 5-HT cells of 1AcKO mice, suggesting increased raphe activation. Serotonin 100-104 FBJ osteosarcoma oncogene B Mus musculus 0-4 28103616-1 2017 In the normal human adrenal gland, serotonin (5-HT) stimulates aldosterone secretion through the 5-HT4 receptor (5-HT4R). Serotonin 35-44 5-hydroxytryptamine receptor 4 Homo sapiens 113-119 9914282-0 1999 Serotonin modulates spike backpropagation and associated [Ca2+]i changes in the apical dendrites of hippocampal CA1 pyramidal neurons. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 112-115 28282869-5 2017 This is the first time that melatonin, 3-indolacetic acid, 5-hydroxytryptophol, and serotonin are proved to significantly inhibit VEGF-induced VEGFR-2 activation in human umbilical vein endothelial cells and subsequent angiogenesis. Serotonin 84-93 kinase insert domain receptor Homo sapiens 143-150 30575146-7 2019 It improved the serotonin content in many brain regions by upregulating tryptophan hydroxylase-2 and 5-hydroxytryptamine1A,2A receptor messenger RNA (mRNA) and downregulating monoamine oxidase A mRNA in the limbic system. Serotonin 16-25 tryptophan hydroxylase 2 Rattus norvegicus 72-102 9928258-1 1998 A very important element controlling serotonin (5-HT) release throughout the brain is the 5-HT1A autoreceptor present on the soma and dendrites of 5-HT neurons since it exerts a negative feedback influence on their firing activity. Serotonin 37-46 5-hydroxytryptamine receptor 1A Homo sapiens 90-96 30446669-3 2018 Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Serotonin 51-60 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 130-151 30446669-3 2018 Here we demonstrate that inhibition of gut-derived serotonin synthesis ameliorates hepatic steatosis through a reduction in liver serotonin receptor 2A (HTR2A) signaling. Serotonin 51-60 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 153-158 27862146-9 2017 Conversely, inactivation of VDR increased serotonin release in cultured HUVECs. Serotonin 42-51 vitamin D receptor Homo sapiens 28-31 9861441-3 1998 The endothelin 1 stimulation of the mouse stomach tone was abolished by the specific serotonin antagonist methizergid. Serotonin 85-94 endothelin 1 Mus musculus 4-16 28103158-1 2017 INTRODUCTION: Research has focused on serotonin (5-HT) 5-HT1D and 5-HT1F receptors to develop drugs acting through non-vasoconstrictive mechanisms for treating acute migraine and those targeting 5-HT2B and 5-HT7 receptors for preventing migraine. Serotonin 38-47 5-hydroxytryptamine receptor 1D Homo sapiens 55-61 28195567-10 2017 Our finding adds to emerging evidence that BDNF val66met contributes to differences in the human brain serotonin system, informing how variability in the 5-HTT level emerges and may represent an important molecular mediator of BDNF val66met effects on behavior and related risk for neuropsychiatric illness. Serotonin 103-112 brain derived neurotrophic factor Homo sapiens 43-47 30142376-0 2018 Axis of serotonin -pERK-YAP in liver regeneration. Serotonin 8-17 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 19-23 30209293-5 2018 In this study, we examined whether serotonin-OXT interaction during the early postnatal period plays a critical role in the restoration of social abnormality in 15q dup mice. Serotonin 35-44 oxytocin Mus musculus 45-48 28195567-10 2017 Our finding adds to emerging evidence that BDNF val66met contributes to differences in the human brain serotonin system, informing how variability in the 5-HTT level emerges and may represent an important molecular mediator of BDNF val66met effects on behavior and related risk for neuropsychiatric illness. Serotonin 103-112 brain derived neurotrophic factor Homo sapiens 227-231 9865811-3 1998 The comorbidity of these disorders may reflect shared neurochemical alterations in the function of serotonin, dopamine, and peptide systems, such as corticotropin releasing factor (CRF) and neuropeptide Y (NPY). Serotonin 99-108 corticotropin releasing hormone Homo sapiens 149-179 27344941-2 2017 Aplysia Sec7 protein (ApSec7), a guanine nucleotide exchange factor for ARF1 and ARF6, induces neurite outgrowth and plays a key role in 5-hydroxyltryptamine-induced neurite growth and synaptic facilitation in Aplysia sensory-motor synapses. Serotonin 137-157 ADP ribosylation factor 1 Homo sapiens 72-76 30209293-8 2018 Thus, serotonin-OXT interaction via 5-HT1A receptors plays a critical role in the normal development of social behavior in 15q dup mice. Serotonin 6-15 oxytocin Mus musculus 16-19 30209293-9 2018 Therefore, targeting serotonin-OXT interaction may provide a novel therapeutic strategy for treatment of ASD. Serotonin 21-30 oxytocin Mus musculus 31-34 9865516-4 1998 The histamine H3 receptor antagonists iodophenpropit and thioperamide did not generate inward currents but were able to inhibit 5-hydroxytryptamine (5-HT) responses with an IC50 of 1.57+/-0.3 microM and 13.7+/-3.5 microM, respectively. Serotonin 128-147 histamine receptor H3 Mus musculus 4-25 30233224-4 2018 Lorcaserin is thought to reduce weight by targeting the serotonin (5HT2c) system to induce satiety. Serotonin 56-65 5-hydroxytryptamine receptor 2C Homo sapiens 67-72 29898451-4 2017 Melatonin is produced via the metabolism of serotonin in two steps which are catalyzed by serotonin N-acetyltransferase (SNAT) and acetylserotonin-O-methyltransferase (ASMT). Serotonin 44-53 aralkylamine N-acetyltransferase Homo sapiens 90-119 29898451-4 2017 Melatonin is produced via the metabolism of serotonin in two steps which are catalyzed by serotonin N-acetyltransferase (SNAT) and acetylserotonin-O-methyltransferase (ASMT). Serotonin 44-53 aralkylamine N-acetyltransferase Homo sapiens 121-125 29898451-4 2017 Melatonin is produced via the metabolism of serotonin in two steps which are catalyzed by serotonin N-acetyltransferase (SNAT) and acetylserotonin-O-methyltransferase (ASMT). Serotonin 44-53 acetylserotonin O-methyltransferase Homo sapiens 131-166 9778657-7 1998 Calculated serotonin synthesis rates reported for [11C]alpha MTP PET studies of humans (Nishizawa et al. Serotonin 11-20 metallothionein 1B Homo sapiens 61-64 29898451-4 2017 Melatonin is produced via the metabolism of serotonin in two steps which are catalyzed by serotonin N-acetyltransferase (SNAT) and acetylserotonin-O-methyltransferase (ASMT). Serotonin 44-53 acetylserotonin O-methyltransferase Homo sapiens 168-172 27824354-4 2016 Subjects were genotyped for the tryptophan hydroxylase-2 (TPH2; G-703T; rs4570625) variant, an enzyme specific for brain serotonin synthesis. Serotonin 121-130 tryptophan hydroxylase 2 Homo sapiens 32-56 27824354-4 2016 Subjects were genotyped for the tryptophan hydroxylase-2 (TPH2; G-703T; rs4570625) variant, an enzyme specific for brain serotonin synthesis. Serotonin 121-130 tryptophan hydroxylase 2 Homo sapiens 58-62 29879404-7 2018 Across both basal and activated inflammatory states, PCB exposure caused greater expression of a subset of inflammatory genes in the hypothalamus and lower expression of genes involved in dopamine, serotonin, and opioid systems compared to oil controls. Serotonin 198-207 pyruvate carboxylase Rattus norvegicus 53-56 29792935-1 2018 LP533401 is an orally bioavailable small molecule that inhibits tryptophan hydroxylase-1, an enzyme responsible for the synthesis of gut-derived serotonin (GDS). Serotonin 145-154 tryptophan hydroxylase 1 Rattus norvegicus 64-88 9778657-10 1998 It seems that the [11C]alpha MTP model for the computation of serotonin synthesis rates is very dependent on plasma free TP concentration and that it may not accurately determine actual serotonin synthesis rates. Serotonin 62-71 metallothionein 1B Homo sapiens 29-32 29759300-0 2018 Decreased contractile response of peripheral arterioles to serotonin after CPB in patients with diabetes. Serotonin 59-68 carboxypeptidase B1 Homo sapiens 75-78 9786223-1 1998 The aim of the present study was to investigate whether the voltage-dependent inhibition of calcium currents by serotonin 5-HT1A agonists can be alleviated (facilitated) by action potential-like depolarizations. Serotonin 112-121 5-hydroxytryptamine receptor 1A Cavia porcellus 122-128 27381555-0 2016 Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males. Serotonin 32-41 monoamine oxidase B Homo sapiens 20-24 9786223-2 1998 In dissociated cholinergic basal forebrain neurons using whole-cell recordings, it is shown that a selective serotonin 5-HT1A agonist (8-OH-DPAT) predominantly blocks N-type HVA calcium current, although a minor reduction of P-type current was also observed. Serotonin 109-118 5-hydroxytryptamine receptor 1A Cavia porcellus 119-125 27509352-8 2016 First, we demonstrated that Nesp55 is co-localized with serotonin and then went on to show that in midbrain regions there were reductions in mRNA expression of the serotonin-specific genes Tph2 and Slc6a4, but not the dopamine-specific gene Th in Nespm/+ mice; suggesting an altered serotonergic system could contribute, in part, to the changes in impulsive behaviour. Serotonin 56-65 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 28-34 27509352-8 2016 First, we demonstrated that Nesp55 is co-localized with serotonin and then went on to show that in midbrain regions there were reductions in mRNA expression of the serotonin-specific genes Tph2 and Slc6a4, but not the dopamine-specific gene Th in Nespm/+ mice; suggesting an altered serotonergic system could contribute, in part, to the changes in impulsive behaviour. Serotonin 164-173 GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Mus musculus 28-34 29501089-0 2018 Oxidative polymerization of 5-hydroxytryptamine to physically and chemically immobilize glucose oxidase for electrochemical biosensing. Serotonin 28-47 hydroxyacid oxidase 1 Homo sapiens 88-103 29453444-4 2018 In this work, we tested the hypothesis that 5-HT2B receptors directly and positively regulate raphe serotonin neuron activity. Serotonin 100-109 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 44-50 29453444-5 2018 By ex vivo electrophysiological recordings, we report that stimulation by the 5-HT2B receptor agonist, BW723C86, increased the firing frequency of serotonin Pet1-positive neurons. Serotonin 147-156 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 78-84 29453444-8 2018 By a conditional genetic ablation that eliminates 5-HT2B receptor expression specifically and exclusively from Pet1-positive serotonin neurons (Htr2b 5-HTKO mice), we demonstrated that behavioral and sensitizing effects of MDMA (3,4-methylenedioxy-methamphetamine), as well as acute behavioral and chronic neurogenic effects of the antidepressant fluoxetine, require 5-HT2B receptor expression in serotonergic neurons. Serotonin 125-134 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 144-149 9845002-4 1998 The main response to serotonin application (2-20 microM) was an inhibition that could be mimicked by 8-OH-DPAT (a 5-HT1A receptor agonist). Serotonin 21-30 5-hydroxytryptamine receptor 1A Homo sapiens 114-129 9787933-4 1998 In addition, serotonin appears to regulate the response of the SCN circadian clock to light through postsynaptic 5-HT1A or 5-ht7 receptors, as well as presynaptic 5-HT1B heteroreceptors on RHT terminals. Serotonin 13-22 5-hydroxytryptamine receptor 1A Homo sapiens 113-119 29555426-1 2018 Brain CYP2D is responsible for the synthesis of endogenous neurotransmitters such as dopamine and serotonin. Serotonin 98-107 cytochrome P450, 2d region Mus musculus 6-11 29524394-0 2018 Sulfation of catecholamines and serotonin by SULT1A3 allozymes. Serotonin 32-41 sulfotransferase family 1A member 3 Homo sapiens 45-52 27108933-1 2016 BACKGROUND: Serotonin (5-HT) and its neurotrophic support system, specifically brain-derived neurotrophic factor (BDNF), are thought to modulate energy homeostasis and susceptibility to obesity. Serotonin 12-21 brain derived neurotrophic factor Homo sapiens 79-112 27108933-1 2016 BACKGROUND: Serotonin (5-HT) and its neurotrophic support system, specifically brain-derived neurotrophic factor (BDNF), are thought to modulate energy homeostasis and susceptibility to obesity. Serotonin 12-21 brain derived neurotrophic factor Homo sapiens 114-118 27511837-0 2016 Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca(2+)-activated chloride channels. Serotonin 42-51 5-hydroxytryptamine receptor 2C Rattus norvegicus 61-66 27511837-6 2016 In all neurons investigated, 5HT potentiated capsaicin-evoked currents through TRPV1 channels, an effect that was attenuated by antagonists at 5HT2A (4 F 4 PP), 5HT2B (SB 204741), as well as 5HT2C (RS 102221) receptors. Serotonin 29-32 5-hydroxytryptamine receptor 2C Rattus norvegicus 191-196 9754116-1 1998 PURPOSE: We sought to create functional images of the serotonin (5-HT) synthesis rate obtained with alpha-[11C]methyl-L-tryptophan (alpha-MTrp) and PET and standardize them into the stereotaxic coordinate system. Serotonin 54-63 lysosomal protein transmembrane 4 alpha Homo sapiens 138-142 28886249-1 2018 Serotonin (5-hydroxytryptamine; 5-HT) inhibits the rat cardioaccelerator sympathetic outflow by 5-HT1B/1D/5 receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 96-102 28886249-1 2018 Serotonin (5-hydroxytryptamine; 5-HT) inhibits the rat cardioaccelerator sympathetic outflow by 5-HT1B/1D/5 receptors. Serotonin 11-30 5-hydroxytryptamine receptor 1B Rattus norvegicus 96-102 27605388-0 2016 ONIOM calculations on serotonin degradation by monoamine oxidase B: insight into the oxidation mechanism and covalent reversible inhibition. Serotonin 22-31 monoamine oxidase B Homo sapiens 47-66 29381782-12 2018 We conclude that serotonin is conveyed from the maternal blood stream through syncytiotrophoblasts, cytotrophoblasts and the villus core to the fetus through a physiological pathway that involves at least SERT, gap junctions, P-gp, OCT3, and MAOA. Serotonin 17-26 solute carrier family 22 member 3 Homo sapiens 232-236 9744926-11 1998 We conclude that serotonin suppresses polysynaptic inhibition in projection neurons of layers II and III of the EC by depression of EPSPs on inhibitory interneurons via 5-HT1A receptors. Serotonin 17-26 5-hydroxytryptamine receptor 1A Homo sapiens 169-175 9732398-0 1998 S 16924 ((R)-2-[1-[2-(2,3-dihydro-benzo[1,4] dioxin-5-Yloxy)-ethyl]-pyrrolidin-3yl]-1-(4-fluoro-phenyl)-ethanone), a novel, potential antipsychotic with marked serotonin (5-HT)1A agonist properties: I. Receptorial and neurochemical profile in comparison with clozapine and haloperidol. Serotonin 160-169 5-hydroxytryptamine receptor 1A Homo sapiens 171-178 27425420-1 2016 The transporters for the neurotransmitters serotonin and dopamine (SERT and DAT, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. Serotonin 43-52 solute carrier family 6 member 3 Homo sapiens 76-79 9690691-1 1998 Ipsapirone, an azapirone with 5-hydroxytryptamine (5-HT1A) partial agonist activity, has been shown in preliminary studies to be effective in the treatment of major depressive disorder. Serotonin 30-49 5-hydroxytryptamine receptor 1A Homo sapiens 51-57 27364433-4 2016 Therefore, this study examined the serotonin-system"s impact on food intake in rat neonates at postnatal day (P) 10 and P18 and the manner in which protein undernutrition during pregnancy and lactation interferes in this behavior. Serotonin 35-44 cyclin-dependent kinase inhibitor 2C Rattus norvegicus 120-123 29203442-10 2018 Furthermore, n-3 PUFA rich diet exposure reverted also serotonin and neurotrophin level reduction in prefrontal cortex of Abeta treated rats. Serotonin 55-64 amyloid beta precursor protein Rattus norvegicus 122-127 29497362-0 2018 Repeated Clozapine Increases the Level of Serotonin 5-HT1AR Heterodimerization with 5-HT2A or Dopamine D2 Receptors in the Mouse Cortex. Serotonin 42-51 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 84-90 9660250-0 1998 Serotonin derivative, N-(p-coumaroyl) serotonin, inhibits the production of TNF-alpha, IL-1alpha, IL-1beta, and IL-6 by endotoxin-stimulated human blood monocytes. Serotonin 0-9 interleukin 1 alpha Homo sapiens 87-96 27891342-7 2016 H score of serotonin expression was significantly higher in cases with totally absent Granular Cell Layer (GCL) as opposed to those with thin/focally absent GCL (p=0.011), and in cases with moderate/strong epidermal inflammation compared to cases with mild inflammation (p=0.035). Serotonin 11-20 germ cell-less 2, spermatogenesis associated Homo sapiens 86-105 27891342-7 2016 H score of serotonin expression was significantly higher in cases with totally absent Granular Cell Layer (GCL) as opposed to those with thin/focally absent GCL (p=0.011), and in cases with moderate/strong epidermal inflammation compared to cases with mild inflammation (p=0.035). Serotonin 11-20 germ cell-less 2, spermatogenesis associated Homo sapiens 107-110 27891342-7 2016 H score of serotonin expression was significantly higher in cases with totally absent Granular Cell Layer (GCL) as opposed to those with thin/focally absent GCL (p=0.011), and in cases with moderate/strong epidermal inflammation compared to cases with mild inflammation (p=0.035). Serotonin 11-20 germ cell-less 2, spermatogenesis associated Homo sapiens 157-160 27424782-3 2016 Exposure to serotonin or the reuptake inhibitor fluoxetine increased runx1 expression and Flk1(+)/cMyb(+) HSPCs independent of peripheral innervation. Serotonin 12-21 kinase insert domain receptor Homo sapiens 90-94 29329285-7 2018 We also provide evidence, from coarse grain MD simulations that the CHOL sites observed in the DAT crystal structures are preserved in all human monoamine transporters (dopamine, serotonin and norepinephrine), suggesting that our findings might extend to the entire family. Serotonin 179-188 solute carrier family 6 member 3 Homo sapiens 95-98 9682221-4 1998 The levels of MAo and B were assayed: MAO A showed a K(m) of 137.1 +/- 16.2 microM and a V(m) of 10.4 +/- 2.5 nmol mg-1 min-1 for serotonin; MAo B had a K(m) of 9.9 +/- 1.6 microM and V(m) of 4.3 +/- 1.1 nmol mg-1 min-1 for beta-phenylethylamine (mean +/- SE of seven hearts). Serotonin 130-139 monoamine oxidase A Homo sapiens 38-43 29206101-5 2017 Here, we show that serotonin (5HT), which is known to regulate gamma power, acts via 5HT2A receptors to suppress an inward-rectifying potassium conductance in FSIs. Serotonin 19-28 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 85-90 29206101-5 2017 Here, we show that serotonin (5HT), which is known to regulate gamma power, acts via 5HT2A receptors to suppress an inward-rectifying potassium conductance in FSIs. Serotonin 30-33 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 85-90 27857753-0 2016 Serotonin regulates brain-derived neurotrophic factor expression in select brain regions during acute psychological stress. Serotonin 0-9 brain-derived neurotrophic factor Rattus norvegicus 20-53 27857753-1 2016 Previous studies suggest that serotonin (5-HT) might interact with brain-derived neurotrophic factor (BDNF) during the stress response. Serotonin 30-39 brain-derived neurotrophic factor Rattus norvegicus 67-100 9703624-4 1998 The administration of MAO a inhibitor pyrazidol promoted the increase in brain serotonin content, normalized brain catecholamine contents and demonstrated positive effect on the animal state. Serotonin 79-88 monoamine oxidase A Homo sapiens 22-27 27857753-1 2016 Previous studies suggest that serotonin (5-HT) might interact with brain-derived neurotrophic factor (BDNF) during the stress response. Serotonin 30-39 brain-derived neurotrophic factor Rattus norvegicus 102-106 26864878-4 2016 A suite of JA- and Et-related mutants including coronatine insensitive1, jasmonic acid resistant1 (jar1), etr1, ein2 and ein3 showed tolerance to serotonin in the inhibition of primary root growth and ROS redistribution within the root tip when compared with wild-type (WT) seedlings. Serotonin 146-155 Signal transduction histidine kinase, hybrid-type, ethylene sensor Arabidopsis thaliana 106-110 27282784-5 2016 Alterations in 5-HT2A and 5-HT2C receptors explain the increase of the response to serotonin in TLR2(-/-) mice. Serotonin 83-92 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 15-21 28948999-9 2017 Taken together, these observations indicate notable changes in endogenous serotonin signaling in 16p11.2 deletion mice and support the therapeutic utility of 5-HT2A receptor antagonists. Serotonin 74-83 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 158-173 9539397-9 1998 The effect on the pituitary-adrenal-axis by depressive disorders and changes in serotonin metabolism have been investigated repeatedly; mainly reported are increased levels of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) in the depressive interval, which may lead to a growth of the adrenal glands. Serotonin 80-89 corticotropin releasing hormone Homo sapiens 176-207 28993428-3 2017 GM1 administration results in decreased levels of mutant huntingtin, the protein that causes HD, and in a wide array of beneficial effects that include changes in levels of DARPP32, ferritin, Iba1 and GFAP, modulation of dopamine and serotonin metabolism, and restoration of normal levels of glutamate, GABA, L-Ser and D-Ser. Serotonin 234-243 coenzyme Q10A Mus musculus 0-3 28757258-8 2017 This study suggests that BDNF over-expression, by inducing changes in pre-synaptic serotonin axonal trophism, is able to exacerbate maladaptive responses to l-DOPA administration. Serotonin 83-92 brain-derived neurotrophic factor Rattus norvegicus 25-29 28668716-10 2017 Further, co-expression analysis of candidate genes in brain suggested ACP1 is important to the regulation of a number of brain mechanisms linked to suicide, including cholesterol synthesis, beta-catenin-mediated signaling pathway, serotonin, GABA, and the stress response via ARHGAP35 (p190rhogap), a repressor of glucocorticoid receptor (NR3C1) transcription. Serotonin 231-240 acid phosphatase 1 Homo sapiens 70-74 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 aralkylamine N-acetyltransferase Homo sapiens 81-115 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 aralkylamine N-acetyltransferase Homo sapiens 117-122 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 aralkylamine N-acetyltransferase Homo sapiens 158-162 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 bromodomain containing 2 Homo sapiens 119-122 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 acetylserotonin O-methyltransferase Homo sapiens 238-275 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 acetylserotonin O-methyltransferase Homo sapiens 277-281 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 acetylserotonin O-methyltransferase Homo sapiens 297-330 27112772-5 2016 It is common knowledge that serotonin is acetylated to form N-acetylserotonin by arylalkylamine N-acetyltransferase (AANAT) or arylamine N-acetyltransferase (SNAT or NAT) and N-acetylserotonin is, subsequently, methylated to melatonin by N-acetylserotonin O-methyltransferase (ASMT; also known as hydroxyindole-O-methyltransferase, HIOMT). Serotonin 28-37 acetylserotonin O-methyltransferase Homo sapiens 332-337 26954509-2 2016 Tryptophan hydroxylase (TPH2) synthesizes serotonin and is over-expressed in suicides. Serotonin 42-51 tryptophan hydroxylase 2 Homo sapiens 24-28 27836486-1 2017 Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. Serotonin 114-123 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 0-33 27836486-1 2017 Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. Serotonin 114-123 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 35-40 27836486-1 2017 Vesicular monoamine transporter 2 (VMAT2, SLC18A2) is a transmembrane transporter protein that packages dopamine, serotonin, norepinephrine, and histamine into vesicles in preparation for neurotransmitter release from the presynaptic neuron. Serotonin 114-123 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 42-49 9539397-9 1998 The effect on the pituitary-adrenal-axis by depressive disorders and changes in serotonin metabolism have been investigated repeatedly; mainly reported are increased levels of corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) in the depressive interval, which may lead to a growth of the adrenal glands. Serotonin 80-89 corticotropin releasing hormone Homo sapiens 209-212 9498802-6 1998 2-MeS-ADP-induced platelet aggregation was also inhibited by A3P5PS but was restored when platelets were further activated by serotonin, a non-aggregating compound, therefore suggesting that P2Y1-mediated stimulation is an absolute prerequisite for ADP to induce platelet aggregation and a key event for platelet activation and aggregation to occur. Serotonin 126-135 purinergic receptor P2Y1 Homo sapiens 191-195 28738293-0 2017 Oxytocin effects on emotional response to others" faces via serotonin system in autism: A pilot study. Serotonin 60-69 oxytocin/neurophysin I prepropeptide Homo sapiens 0-8 9635159-5 1998 The metabolically stable NK1 receptor agonist, [Sar9,Met(O2)11] substance P, caused a 49% increase in 5-hydroxytryptamine release above basal levels. Serotonin 102-121 tachykinin receptor 1 Rattus norvegicus 25-37 28794131-1 2017 BACKGROUND: Autosomal recessive mutations in DNAJC12, encoding a cochaperone of HSP70 with hitherto unknown function, were recently described to lead to hyperphenylalaninemia, central monoamine neurotransmitter (dopamine and serotonin) deficiency, dystonia and intellectual disability in six subjects affected by homozygous variants. Serotonin 225-234 heat shock protein family A (Hsp70) member 4 Homo sapiens 80-85 9794145-5 1998 The relative risk with different drug combinations is assessed from available evidence and argued to be strongly associated with the degree of elevation of 5-hydroxytryptamine, which is greatest following combinations of irreversible inhibitors of monoamine oxidase A and B with potent serotonin reuptake inhibitors. Serotonin 156-175 monoamine oxidase A Homo sapiens 248-267 27895323-10 2017 Altogether, this study indicates that elevated CYP2C19 expression is associated with depressive symptoms, reduced hippocampal volume and impairment of hippocampal serotonin and BDNF homeostasis. Serotonin 163-172 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 47-54 28657744-1 2017 A series of N-substituted (2-phenylcyclopropyl)methylamines were designed and synthesized, with the aim of finding serotonin 2C (5-HT2C)-selective agonists with a preference for Gq signaling. Serotonin 115-124 5-hydroxytryptamine receptor 2C Homo sapiens 129-135 9541929-0 1998 [Relationship between regulatory effects of serotonin and testosterone on the development of the LHRH producing system of the rat brain during the prenatal period of development]. Serotonin 44-53 gonadotropin releasing hormone 1 Rattus norvegicus 97-101 28316078-2 2017 The sour sensing cells, Type III cells, release serotonin (5-HT) in response to the presence of sour (acidic) tastants and this released 5-HT activates 5-HT3 receptors on the gustatory nerves. Serotonin 48-57 hypothermia due to alcohol sensitivity 3 Mus musculus 154-157 28041791-0 2017 Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin. Serotonin 91-100 ETS variant transcription factor 5b Danio rerio 22-27 9427346-5 1997 These data suggest the involvement of 5-HT1D receptors in the mitogenic and proliferative effects of serotonin during early embryonic development. Serotonin 101-110 5-hydroxytryptamine (serotonin) receptor 1D Mus musculus 38-44 27788626-6 2017 The loss of 5HT can enhance neural excitability by reducing membrane-bound K+-Cl- cotransporter 2, a cotransporter that regulates the outward flow of Cl-. Serotonin 12-15 solute carrier family 12 member 5 Homo sapiens 75-97 9314028-0 1997 Postsynaptic 5-HT1A receptors mediate 5-hydroxytryptamine release in the amygdala through a feedback to the caudal linear raphe. Serotonin 38-57 5-hydroxytryptamine receptor 1A Homo sapiens 13-19 29050222-2 2017 Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system. Serotonin 355-364 brain-derived neurotrophic factor Rattus norvegicus 139-172 29050222-2 2017 Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system. Serotonin 355-364 brain-derived neurotrophic factor Rattus norvegicus 174-178 29050222-2 2017 Our previous study demonstrated that purely psychological stress without any physic stimuli induces a biphasic change in the expression of brain-derived neurotrophic factor (BDNF), which immediately decrease and then gradually increase after the stress; and that the latter BDNF increase in response to the psychological stress involves the activation of serotonin system. Serotonin 355-364 brain-derived neurotrophic factor Rattus norvegicus 274-278 9314028-1 1997 Using brain microdialysis, it was demonstrated that the release of 5-hydroxytryptamine (5-HT) in the central nucleus of the amygdala is under inhibitory control of somatodendritic and postsynaptic 5-HT1A receptors. Serotonin 67-86 5-hydroxytryptamine receptor 1A Homo sapiens 197-203 28057699-5 2017 Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin 134-143 glucagon-like peptide 1 receptor Rattus norvegicus 215-221 9255139-3 1997 In most cases, two or more types of medications known to increase the activity of serotonin at the 5-HT1A receptor are required to produce it, and it frequently begins soon after the initiation of a new treatment regimen. Serotonin 82-91 5-hydroxytryptamine receptor 1A Homo sapiens 99-114 28057699-6 2017 Serotonin turnover and expression of 5-hydroxytryptamine (5-HT) 2A (5-HT2A) and 5-HT2C serotonin receptors in the hypothalamus were altered by GLP-1R activation. Serotonin 0-9 glucagon-like peptide 1 receptor Rattus norvegicus 143-149 28057699-10 2017 We show that GLP-1R stimulation in DR is sufficient to induce hypophagia and increase the electrical activity of the DR serotonin neurons. Serotonin 120-129 glucagon-like peptide 1 receptor Rattus norvegicus 13-19 28057699-12 2017 This study identifies serotonin as a new critical neural substrate for GLP-1 impact on energy homeostasis and expands the current map of brain areas impacted by GLP-1R activation. Serotonin 22-31 glucagon Rattus norvegicus 71-76 9223549-0 1997 S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. Serotonin 48-57 5-hydroxytryptamine receptor 1A Homo sapiens 59-66 28368307-4 2017 It is synthesized from serotonin in two steps, with a rate-limiting step carried out by arylalkymine N-acetyltransferase (AANAT). Serotonin 23-32 aralkylamine N-acetyltransferase Homo sapiens 88-120 9135093-7 1997 5-hydroxytryptamine2C receptor messenger RNA was decreased in ventral CA1 only in adrenal-intact rats, suggesting a corticosterone effect, and decreased in the subiculum in both groups, indicating 5-hydroxytryptamine mediation. Serotonin 0-19 carbonic anhydrase 1 Rattus norvegicus 70-73 28368307-4 2017 It is synthesized from serotonin in two steps, with a rate-limiting step carried out by arylalkymine N-acetyltransferase (AANAT). Serotonin 23-32 aralkylamine N-acetyltransferase Homo sapiens 122-127 26975194-0 2017 Serotonin and the Brain"s Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome. Serotonin 0-9 tryptophan hydroxylase 2 Homo sapiens 91-95 26975194-3 2017 Tryptophane hydroxylase 2 (TPH2) is a rate-limiting enzyme in the biosynthesis of serotonin and is known to inhibit, in addition to its role as a trans-synaptic messenger, axonal and dendritic growth. Serotonin 82-91 tryptophan hydroxylase 2 Homo sapiens 0-25 26975194-3 2017 Tryptophane hydroxylase 2 (TPH2) is a rate-limiting enzyme in the biosynthesis of serotonin and is known to inhibit, in addition to its role as a trans-synaptic messenger, axonal and dendritic growth. Serotonin 82-91 tryptophan hydroxylase 2 Homo sapiens 27-31 28128367-4 2017 FLP-7 is secreted as a neuroendocrine peptide in proportion to fluctuations in neural serotonin circuit functions, and its release is regulated from secretory neurons via the nutrient sensor AMPK. Serotonin 86-95 TPMQRSSMVRF-amide 2 Caenorhabditis elegans 0-5 27926628-6 2017 In a sample of normal human individuals, we studied the effects of a single nucleotide polymorphism (rs4570625) in the gene that encodes the rate-limiting enzyme in serotonin synthesis, TPH2, on metacontrast masking. Serotonin 165-174 tryptophan hydroxylase 2 Homo sapiens 186-190 28053672-0 2017 Serotonin improves glucose metabolism by Serotonylation of the small GTPase Rab4 in L6 skeletal muscle cells. Serotonin 0-9 RAB4A, member RAS oncogene family Mus musculus 76-80 27289535-2 2017 Acetylcholine, serotonin, and dopamine (DA) are released from cell soma and/or dendrites if ATP6V0C is expressed in cultured cells. Serotonin 15-24 ATPase, H+ transporting, lysosomal V0 subunit C Mus musculus 92-99 28009296-4 2016 Serotonin secretion from beta cells decreases cyclic AMP (cAMP) levels in neighboring alpha cells via 5-HT1F receptors and inhibits glucagon secretion. Serotonin 0-9 5-hydroxytryptamine receptor 1F Homo sapiens 102-108 27694974-1 2016 Indatraline is an antidepressive agent and a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Serotonin 148-157 solute carrier family 18 member A2 Rattus norvegicus 59-80 26620050-4 2016 Previously, we found that HL had increased levels of transcriptional expression of the receptors for serotonin (HTR1a, HTR1b), estrogen (Eralpha), dopamine (D1a), and prolactin (Prlr) than LL in the olfactory bulb (OB); however, the molecular mechanisms behind this phenomenon are unknown. Serotonin 101-110 5-hydroxytryptamine receptor 1B Rattus norvegicus 119-124 26740292-1 2016 BACKGROUND AND OBJECTIVE: LP533401 is an inhibitor of tryptophan hydroxylase 1, which regulates serotonin production in the gut. Serotonin 96-105 tryptophan hydroxylase 1 Rattus norvegicus 54-78 27189957-2 2016 Here, we evaluated whether our recent finding of elevated neural serotonin synthesis rate in patients with social anxiety disorder could be reproduced in a separate cohort, and whether allelic variation in the tryptophan hydroxylase-2 (TPH2) G-703T polymorphism relates to differences in serotonin synthesis assessed with positron emission tomography. Serotonin 288-297 tryptophan hydroxylase 2 Homo sapiens 236-240 27189957-7 2016 In patients, the serotonin synthesis rate in the amygdala and anterior cingulate cortex was significantly elevated in TPH2 T carriers in comparison with GG homozygotes. Serotonin 17-26 tryptophan hydroxylase 2 Homo sapiens 118-122 27320409-4 2016 Oxytocin is involved in sexual function and is interconnected with serotonin within the brain. Serotonin 67-76 oxytocin/neurophysin I prepropeptide Homo sapiens 0-8 27761358-1 2016 Tryptophan hydroxylase 2 (TPH2) catalyses the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia. Serotonin 100-109 tryptophan hydroxylase 2 Homo sapiens 0-24 27761358-1 2016 Tryptophan hydroxylase 2 (TPH2) catalyses the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia. Serotonin 100-109 tryptophan hydroxylase 2 Homo sapiens 26-30 27466333-7 2016 Because serotonin- and adenosine-dependent pMF interact via cross talk inhibition, we hypothesized that pMF is obscured because the competing mechanisms of pMF are balanced and offsetting during mASH. Serotonin 8-17 growth factor receptor bound protein 2 Mus musculus 195-199 27167299-0 2016 BDNF isoforms: a round trip ticket between neurogenesis and serotonin? Serotonin 60-69 brain derived neurotrophic factor Homo sapiens 0-4 27190169-6 2016 Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum). Serotonin 154-163 solute carrier family 6 member 3 Homo sapiens 52-72 27190169-6 2016 Inasmuch as they increase synaptic dopamine levels, dopamine transporter (DAT) inhibitors, whether they are selective or have actions on noradrenaline or serotonin transporters, theoretically represent an attractive way to alleviate parkinsonism per se and potentially enhance l-DOPA antiparkinsonian action (provided that sufficient dopamine terminals remain within the striatum). Serotonin 154-163 solute carrier family 6 member 3 Homo sapiens 74-77 27512006-6 2016 These results suggest that serotonin mediates the leptin- and AM 251-dependent regulation of feeding behavior in rats via the 5-HT1B and 5-HT2C receptors. Serotonin 27-36 5-hydroxytryptamine receptor 1B Rattus norvegicus 126-132 26822114-8 2016 Interestingly, we also found a significant decrease of serotonin in the heads of homozygous scn1Lab(-/-) mutants as compared to the wild type zebrafish, which suggest that neurochemical defects might play a crucial role in the pathophysiology of DS. Serotonin 55-64 sodium channel, voltage-gated, type I like, alpha b Danio rerio 92-99 9059863-2 1997 This study describes a method whereby the degree of receptor reserve, with respect to 5-hydroxytryptamine (5-HT), was determined for a HeLa cell line expressing the human 5-HT1A receptor using the agonist-induced [35S]guanosine 5"[gamma-thio]triphosphate ([35S]GTP gamma S) binding assay, followed by a comparison of the potencies and relative efficacies of several compounds. Serotonin 86-105 5-hydroxytryptamine receptor 1A Homo sapiens 171-186 27147980-2 2016 In addition to mediating vesicular loading of glutamate, it has been proposed that VGLUT3 enhances serotonin (5-HT) vesicular loading by the vesicular monoamine transporter (VMAT2) in 5-HT neurons. Serotonin 99-108 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 174-179 9030094-3 1997 In the present study, the effects of preformed inflammatory mediators (histamine and serotonin) on the induction and expression of MHC class II, E-selectin, and ICAM-1 molecules by human umbilical vein endothelial cells were examined. Serotonin 85-94 selectin E Homo sapiens 145-155 27800509-3 2016 We have previously reported hyperplasia of NEBs in the lungs of Phd1-/- mice associated with enhanced serotonin secretion. Serotonin 102-111 egl-9 family hypoxia-inducible factor 2 Mus musculus 64-68 26693696-7 2016 In vitro, SER significantly reduced osteogenic differentiation and mineralization of rat calvarial cells with concomitant reduction of osteoblast marker genes including alkaline phosphatase (Alpl), osterix (Sp7), and osteocalcin (Bglap). Serotonin 10-13 Sp7 transcription factor Rattus norvegicus 198-205 26693696-7 2016 In vitro, SER significantly reduced osteogenic differentiation and mineralization of rat calvarial cells with concomitant reduction of osteoblast marker genes including alkaline phosphatase (Alpl), osterix (Sp7), and osteocalcin (Bglap). Serotonin 10-13 Sp7 transcription factor Rattus norvegicus 207-210 29897692-1 2016 Tryptophan hydroxylase I(TPH1) catalases the 5-hydroxylation reaction of L-Trp, which is the rate-limiting step in the synthesis of serotonin. Serotonin 132-141 tryptophan hydroxylase 1 L homeolog Xenopus laevis 25-29 27112704-5 2016 Serotonin"s homeostasis involves serotoninergic autoreceptor such as 5-HT1A, 5-HT1B, 5-HT1D, the enzymatic degradation of serotonin by monoamine oxidase A (MAO-A), and a transporter (serotoninergic transporter [SERT]). Serotonin 0-9 5-hydroxytryptamine receptor 1D Homo sapiens 85-91 27194330-3 2016 This serotonin- or morphine-dependent modulation can be rescued in npr-17-null animals by the expression of npr-17 or a human kappa opioid receptor in the two ASI sensory neurons, with ASI opioid signaling selectively inhibiting ASI neuropeptide release. Serotonin 5-14 opioid receptor kappa 1 Homo sapiens 126-147 9605843-3 1997 Serotonin is acetylated to N-acetylserotonin by serotonin N-acetyltransferase (SNAT) and then methylated to form melatonin by hydroxyindole-O-methyltransferase (HIOMT). Serotonin 0-9 arylalkylamine N-acetyltransferase Mus musculus 48-77 9605843-3 1997 Serotonin is acetylated to N-acetylserotonin by serotonin N-acetyltransferase (SNAT) and then methylated to form melatonin by hydroxyindole-O-methyltransferase (HIOMT). Serotonin 0-9 arylalkylamine N-acetyltransferase Mus musculus 79-83 26744351-4 2016 Here we observed that the serotonin 2B receptor (5-HT2B), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of ALS. Serotonin 26-35 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 49-55 26744351-4 2016 Here we observed that the serotonin 2B receptor (5-HT2B), a serotonin receptor expressed in microglia, is upregulated in the spinal cord of three different transgenic mouse models of ALS. Serotonin 60-69 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 49-55 27212180-2 2016 Previous studies have shown a significant interaction between serotonin and brain-derived neurotrophic factor (BDNF) in brain function. Serotonin 62-71 brain derived neurotrophic factor Homo sapiens 76-109 9097028-1 1997 We examined the effects of diminished serotonin (5-hydroxytryptamine, 5-HT) levels on the postnatal development of striatal tachykinin and enkephalin neuropeptide systems. Serotonin 38-47 proenkephalin Rattus norvegicus 139-149 27212180-2 2016 Previous studies have shown a significant interaction between serotonin and brain-derived neurotrophic factor (BDNF) in brain function. Serotonin 62-71 brain derived neurotrophic factor Homo sapiens 111-115 26023064-2 2016 Neurons expressing the neuropeptide, relaxin-3 (RLN3), and its cognate receptor, RXFP3, constitute a putative "ascending arousal system", which shares neuroanatomical and functional similarities with serotonin (5-HT)/dorsal raphe and noradrenaline (NA)/locus coeruleus monoamine systems. Serotonin 200-209 relaxin 3 Mus musculus 37-46 9285924-4 1997 In the gut, expression of IAPP varied among species; when present, IAPP was most abundant in the proximal part and co-localized with somatostatin, PYY, gastrin/cholecystokinin, enteroglucagon or serotonin. Serotonin 195-204 islet amyloid polypeptide Rattus norvegicus 67-71 26023064-2 2016 Neurons expressing the neuropeptide, relaxin-3 (RLN3), and its cognate receptor, RXFP3, constitute a putative "ascending arousal system", which shares neuroanatomical and functional similarities with serotonin (5-HT)/dorsal raphe and noradrenaline (NA)/locus coeruleus monoamine systems. Serotonin 200-209 relaxin 3 Mus musculus 48-52 26887983-2 2016 AA-NAT converts serotonin to N-acetylserotonin, the ultimate precursor of melatonin. Serotonin 16-25 aralkylamine N-acetyltransferase Homo sapiens 0-6 27016479-0 2016 Serotonin suppresses beta-casein expression via PTP1B activation in human mammary epithelial cells. Serotonin 0-9 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 48-53 26907598-6 2016 Daily oral administration of the TPH1 inhibitor (LX1032) for 6 weeks reduced PSL and increased the trabecular bone volume and trabecular number of the spine and femur in high-5HT rats. Serotonin 175-178 tryptophan hydroxylase 1 Rattus norvegicus 33-37 9238850-25 1997 By using the CREM-deficient mice and by analysis of the regulatory region of the gene encoding the serotonin NAT, we have established that ICER is responsible for the amplitude and rhythmicity of NAT and thus for the oscillation in the hormonal synthesis of melatonin. Serotonin 99-108 solute carrier family 38, member 3 Mus musculus 109-112 26844389-5 2016 TpH2 is the rate-limiting enzyme for serotonin (5-HT) synthesis and has been implicated in the etiology of human affective disorders. Serotonin 37-46 tryptophan hydroxylase 2 Homo sapiens 0-4 9238850-25 1997 By using the CREM-deficient mice and by analysis of the regulatory region of the gene encoding the serotonin NAT, we have established that ICER is responsible for the amplitude and rhythmicity of NAT and thus for the oscillation in the hormonal synthesis of melatonin. Serotonin 99-108 solute carrier family 38, member 3 Mus musculus 196-199 9031588-3 1996 Biosynthesis enzymes of catecholamines such as DBH (dopamine beta hydroxylase) and PNMT (phenylethanol amine-N-methyl transferase) as well as the neurotransmitter serotonin , can be detected by immunohistochemical techniques from 15 to 20 prenatal days. Serotonin 163-172 dopamine beta-hydroxylase Homo sapiens 52-77 26968113-8 2016 Ex vivo serotonin and agonists of the 5-HT2A and 5-HT2B receptors restored IL-17 secretion from splenocytes and Th17 cell differentiation in Tph1(-/-) mice. Serotonin 8-17 interleukin 17A Mus musculus 75-80 26899501-0 2016 Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin. Serotonin 97-106 brain derived neurotrophic factor Homo sapiens 14-47 26899501-0 2016 Regulation of brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain by serotonin. Serotonin 97-106 brain derived neurotrophic factor Homo sapiens 49-53 8944643-3 1996 Tyrosine phosphorylation of paxillin increased by three- to fourfold with a time course similar to force development during contractile stimulation with acetylcholine (ACh), 5-hydroxytryptamine, and KCl and decreased during washout of contractile stimuli and during relaxation induced by forskolin. Serotonin 174-193 paxillin Homo sapiens 28-36 26877074-2 2016 Upon exposure of sensory neurons to the neurotransmitter serotonin (5-HT), CREB1 is activated via activation of the protein kinase A (PKA) intracellular signaling pathways, and CREB2 as a transcriptional repressor is relieved possibly via phosphorylation of CREB2 by mitogen-activated protein kinase (MAPK). Serotonin 57-66 cAMP responsive element binding protein 1 Homo sapiens 75-80 26877074-2 2016 Upon exposure of sensory neurons to the neurotransmitter serotonin (5-HT), CREB1 is activated via activation of the protein kinase A (PKA) intracellular signaling pathways, and CREB2 as a transcriptional repressor is relieved possibly via phosphorylation of CREB2 by mitogen-activated protein kinase (MAPK). Serotonin 57-66 activating transcription factor 2 Homo sapiens 177-182 26877074-2 2016 Upon exposure of sensory neurons to the neurotransmitter serotonin (5-HT), CREB1 is activated via activation of the protein kinase A (PKA) intracellular signaling pathways, and CREB2 as a transcriptional repressor is relieved possibly via phosphorylation of CREB2 by mitogen-activated protein kinase (MAPK). Serotonin 57-66 activating transcription factor 2 Homo sapiens 258-263 8889283-8 1996 The most reliable variables to assess inhibition of MAO-A and -B in humans proved to be DHPG in plasma and serotonin in platelets and MAO-B activity in platelets, respectively. Serotonin 107-116 monoamine oxidase A Homo sapiens 52-64 26930051-6 2016 These actions of serotonin were mimicked by the activation of either 5-HT1B or 5-HT2A receptors, but not by the activation of the 5-HT1A subtype. Serotonin 17-26 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 79-85 8873352-1 1996 At clinically relevant doses, selective serotonin (5-HT) reuptake inhibitors (SSRIs) and MAO inhibitors (MAOIs) increase the extracellular concentration of 5-HT in the midbrain raphe nuclei, thereby activating inhibitory somatodendritic 5-HT1A autoreceptors. Serotonin 40-49 5-hydroxytryptamine receptor 1A Homo sapiens 237-243 27162617-9 2016 Thus, increased intracellular serotonin caused by increased SERT expression may contribute to PAH pathobiology by dysregulation of estrogen metabolic pathways via increased CYP1B1 activity. Serotonin 30-39 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 173-179 8883849-0 1996 Acute and chronic actions of ethanol on CA1 hippocampal responses to serotonin. Serotonin 69-78 carbonic anhydrase 1 Rattus norvegicus 40-43 8883849-1 1996 The effects of acute or chronic ethanol on serotonin (5-HT)-induced membrane hyperpolarization and inhibition of the slow Ca2(+)-dependent after hyperpolarization (sAHP) were recorded in rat CA1 pyramidal neurons in hippocampal slices using sharp intracellular electrodes. Serotonin 43-52 carbonic anhydrase 1 Rattus norvegicus 191-194 8843032-1 1996 Modulation of N-methyl-D-aspartate (NMDA) receptor-mediated ion currents by serotonin was investigated with a two-electrode voltage clamp technique in Xenopus oocytes injected with rat brain RNA. Serotonin 76-85 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 14-50 8843032-2 1996 After a 1-min application of 200 nM serotonin a transient potentiation of the NMDA receptor-mediated ion currents was observed. Serotonin 36-45 glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis 78-91 8709108-3 1996 As the first compounds reported with such selectivity and enhanced receptor affinity, these tetrahydro-beta-carboline antagonists are useful tools for elucidating the role of serotonin acting at the 5HT2B receptor in normal and disease physiology. Serotonin 175-184 5-hydroxytryptamine receptor 2B Rattus norvegicus 199-204 8807295-6 1996 Mutations in several other genes, including unc-8, unc-10, unc-20, unc-35, unc-75, unc-77, and snt-1 also result in hypersensitivity to serotonin. Serotonin 136-145 Degenerin unc-8 Caenorhabditis elegans 44-49 8807295-6 1996 Mutations in several other genes, including unc-8, unc-10, unc-20, unc-35, unc-75, unc-77, and snt-1 also result in hypersensitivity to serotonin. Serotonin 136-145 RRM domain-containing protein Caenorhabditis elegans 75-81 8809673-1 1996 In this study we describe modulatory effects exerted by in vivo activation of corticosteroid receptors on 5HT responsiveness of rat CA1 pyramidal neurons. Serotonin 106-109 carbonic anhydrase 1 Rattus norvegicus 132-135 8809673-8 1996 Altogether, this study presents further evidence that 5HT transmission in hippocampal CA1 area is modulated by differential steroid receptor activation as may occur under physiological circumstances due to different plasma concentrations of corticosterone. Serotonin 54-57 carbonic anhydrase 1 Rattus norvegicus 86-89 8601816-1 1996 The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants, including serotonin- and norepinephrine-selective reuptake inhibitors, increases the expression of cAMP response element binding protein (CREB) mRNA in rat hippocampus. Serotonin 133-142 cAMP responsive element binding protein 1 Rattus norvegicus 222-259 8601816-1 1996 The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants, including serotonin- and norepinephrine-selective reuptake inhibitors, increases the expression of cAMP response element binding protein (CREB) mRNA in rat hippocampus. Serotonin 133-142 cAMP responsive element binding protein 1 Rattus norvegicus 261-265 8882616-0 1996 Antagonistic actions of renal dopamine and 5-hydroxytryptamine: increase in Na+, K(+)-ATPase activity in renal proximal tubules via activation of 5-HT1A receptors. Serotonin 43-62 5-hydroxytryptamine receptor 1A Homo sapiens 146-152 8965658-5 1996 They also suggest the coexistence of the isoenzymes in raphe neurons as well as the potential role of MAO-A in metabolizing serotonin in vivo. Serotonin 124-133 monoamine oxidase A Homo sapiens 102-107 8919640-6 1996 We conclude that the 5-HT1A receptor modulates these two pathways differently, and that the overall response to challenge with serotonin, in terms of both phosphatidyl inositol hydrolysis and cyclic AMP production, is dependent upon receptor number. Serotonin 127-136 5-hydroxytryptamine receptor 1A Homo sapiens 21-36 8992611-1 1996 A potent and selective serotonin (5-HT1A) partial agonist with potential as a human anxiolytic drug was given in oral doses of 0, 5, 15, or 50 mg/kg/day by gavage to Sprague-Dawley rats for 6 or 12 mo. Serotonin 23-32 5-hydroxytryptamine receptor 1A Homo sapiens 34-40 8645269-0 1996 A serotonin receptor gene (5HT1A) variant found in a Tourette"s syndrome patient. Serotonin 2-11 5-hydroxytryptamine receptor 1A Homo sapiens 27-32 9199118-2 1996 The aim of the presented study is to evaluate the linear correlation between: 1) serum dopamine-beta hydroxylase activity and the dopamine concentration in plasma as well as 24-hours adrenaline and noradrenaline excretion in the urine; and 2) between catechol-0-methyltransferase and monoaminoxidase activity and the 24-hours excretion of catecholamine in the urine; next the serum and platelet concentration of serotonin and the arterial blood pressure in women chronically exposed to carbon disulfide. Serotonin 412-421 dopamine beta-hydroxylase Homo sapiens 87-112 8632725-6 1996 Serotonin (5-HT), a preferred substrate for MAO-A, was not oxidized by AB(161-375)A or wild-type MAO-B. Serotonin 0-9 monoamine oxidase A Homo sapiens 44-49 8925288-0 1995 Serotonin and 8-OH-DPAT reduce excitatory transmission in rat hippocampal area CA1 via reduction in presumed presynaptic Ca2+ entry. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 79-82 7589574-3 1995 Treatment of rat mesangial cells with platelet products PDGF-AB, PDGF-BB or serotonin transiently induced MCP-1 expression with a maximum after 2 to 4 h and a decline to baseline after 6 to 8 h. Different kinetics were observed with interleukin-1 beta (IL-1 beta), which induced a long lasting elevation of MCP-1 mRNA for more than 20 h. Together, PDGF and IL-1 beta synergistically induced MCP-1 expression. Serotonin 76-85 C-C motif chemokine ligand 2 Rattus norvegicus 106-111 7589574-3 1995 Treatment of rat mesangial cells with platelet products PDGF-AB, PDGF-BB or serotonin transiently induced MCP-1 expression with a maximum after 2 to 4 h and a decline to baseline after 6 to 8 h. Different kinetics were observed with interleukin-1 beta (IL-1 beta), which induced a long lasting elevation of MCP-1 mRNA for more than 20 h. Together, PDGF and IL-1 beta synergistically induced MCP-1 expression. Serotonin 76-85 C-C motif chemokine ligand 2 Rattus norvegicus 307-312 26842107-2 2016 This paper describes the protocol for a randomised controlled trial (MIR) to investigate the extent to which the addition of the antidepressant mirtazapine is effective in reducing the symptoms of depression compared with placebo in patients who are still depressed after they have been treated with a selective serotonin reuptake inhibitor (SSRI) or serotonin and noradrenaline reuptake inhibitor (SNRI) for at least 6 weeks in primary care. Serotonin 312-321 membrane associated ring-CH-type finger 8 Homo sapiens 69-72 7472476-0 1995 Serotonin reduces inhibition via 5-HT1A receptors in area CA1 of rat hippocampal slices in vitro. Serotonin 0-9 carbonic anhydrase 1 Rattus norvegicus 58-61 26808090-8 2016 KEY FINDINGS: Consecutive administration of any agents increased PVR dose-dependently with the maximal responsiveness being PAF>LTC4>serotonin>>histamine=PGD2. Serotonin 139-148 prostaglandin D2 synthase (brain) Mus musculus 166-170 26808090-12 2016 SIGNIFICANCE: Anaphylactic mediators exert non-uniform actions on the pulmonary and systemic circulation and airway in anesthetized BALB/c mice: PAF, LTC4 and serotonin cause substantial pulmonary vasoconstriction, while histamine biphasic responses of the initial nitric oxide dependent vasodilation followed by vasoconstriction; PAF, serotonin, and histamine, but not LTC4 or PGD2, evoke systemic vasodilatation; only serotonin induces airway constriction. Serotonin 159-168 prostaglandin D2 synthase (brain) Mus musculus 378-382 7472476-1 1995 We studied the effects of serotonin (5-HT) on intrinsic and synaptic responses of hippocampal CA1 cells. Serotonin 26-35 carbonic anhydrase 1 Rattus norvegicus 94-97 26790951-2 2016 Here we show that in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible transcription factor, and that 5-HT subsequently promotes axon regeneration by autocrine signalling through the SER-7 5-HT receptor. Serotonin 83-92 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 282-287 26573960-10 2016 Free serotonin led to an increase in the expression of RUNX2 in breast cancer cells (MDA-MB-231), which directly inhibited osteoblast differentiation and stimulated osteoclast differentiation by the PTHrP/RANKL pathway, which caused bone destruction and formed osteolytic bone lesions. Serotonin 5-14 TNF superfamily member 11 Homo sapiens 205-210 7576268-5 1995 This syndrome is caused by excess serotonin (5-hydroxytryptamine; 5-HT) availability in the CNS at the 5-HT1A-receptor. Serotonin 34-43 5-hydroxytryptamine receptor 1A Homo sapiens 103-118 26219576-8 2016 Medial prefrontal cortex expression of tryptophan hydroxylase-2 (TPH2; enzyme necessary for serotonin synthesis) was negatively associated with early maternal licking received. Serotonin 92-101 tryptophan hydroxylase 2 Rattus norvegicus 39-63 26219576-8 2016 Medial prefrontal cortex expression of tryptophan hydroxylase-2 (TPH2; enzyme necessary for serotonin synthesis) was negatively associated with early maternal licking received. Serotonin 92-101 tryptophan hydroxylase 2 Rattus norvegicus 65-69 26790951-2 2016 Here we show that in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible transcription factor, and that 5-HT subsequently promotes axon regeneration by autocrine signalling through the SER-7 5-HT receptor. Serotonin 94-98 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 282-287 27040628-10 2016 In conclusion, allergic mediators exert non-uniform actions on pulmonary and systemic circulation and airways in anesthetized SD rats: PAF, LTC4 and PGD2, but not histamine or serotonin, caused substantial pulmonary vasoconstriction; LTC4 yielded systemic vasoconstriction, while the others caused systemic vasodilatation; only two mediators, PAF and serotonin, induce airway constriction. Serotonin 351-360 PCNA clamp associated factor Rattus norvegicus 135-138 7576268-5 1995 This syndrome is caused by excess serotonin (5-hydroxytryptamine; 5-HT) availability in the CNS at the 5-HT1A-receptor. Serotonin 45-64 5-hydroxytryptamine receptor 1A Homo sapiens 103-118 7543257-4 1995 With norepinephrine, serotonin, prostaglandin F2 alpha, and K+, Cao from 0.025 to 0.8 mM induced a graded increase in Cai and active stress. Serotonin 21-30 carbonic anhydrase 1 Rattus norvegicus 118-121 25547097-3 2016 By decreasing the availability of tryptophan for serotonin synthesis, such IDO and TDO-driven TRYCATs, also decrease the availability of serotonin for N-acetylserotonin (NAS) and melatonin synthesis. Serotonin 49-58 tryptophan 2,3-dioxygenase Homo sapiens 83-86 25547097-3 2016 By decreasing the availability of tryptophan for serotonin synthesis, such IDO and TDO-driven TRYCATs, also decrease the availability of serotonin for N-acetylserotonin (NAS) and melatonin synthesis. Serotonin 137-146 tryptophan 2,3-dioxygenase Homo sapiens 83-86 26655496-4 2016 The serotonin neurons express a series of molecules essential for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiological properties and release serotonin in an activity-dependent manner. Serotonin 4-13 tryptophan hydroxylase 2 Homo sapiens 102-126 26655496-4 2016 The serotonin neurons express a series of molecules essential for serotonergic development, including tryptophan hydroxylase 2, exhibit typical electrophysiological properties and release serotonin in an activity-dependent manner. Serotonin 188-197 tryptophan hydroxylase 2 Homo sapiens 102-126 7566509-0 1995 Involvement of serotonin in the regulation of GnRH gene expression in the male rat brain. Serotonin 15-24 gonadotropin releasing hormone 1 Rattus norvegicus 46-50 26259125-12 2015 Finally, a subendocardial left ventricular fibrosis was induced by chronic serotonin in wild-type mice, which was increased in Htr2B animals, but prevented in Htr2A and Htr2A/2B mice, and could be explained by a contribution of the endothelial 5-HT2BRs to coronary vasodilatation. Serotonin 75-84 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 127-132 26259125-12 2015 Finally, a subendocardial left ventricular fibrosis was induced by chronic serotonin in wild-type mice, which was increased in Htr2B animals, but prevented in Htr2A and Htr2A/2B mice, and could be explained by a contribution of the endothelial 5-HT2BRs to coronary vasodilatation. Serotonin 75-84 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 169-174 26428905-3 2016 Adult (4-6 months of age), VMAT2 LO mice exhibit dramatically reduced (90%) serotonin release capacity, as measured by fast scan cyclic voltammetry. Serotonin 76-85 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 27-32 26393369-1 2015 The isozymes of monoamine oxidase (MAO-A and MAO-B) are important enzymes involved in the metabolism of numerous biogenic amines, including the neurotransmitters serotonin, dopamine, and norepinephrine. Serotonin 162-171 monoamine oxidase B Rattus norvegicus 45-50 26256010-9 2015 A multivariable stepwise regression model showed that only serotonin 5-HT2c (AOR=2.13, CI 95% 1.72-2.64) and histamine H1 (AOR=1.91, CI 95% 1.38-2.64) predicted the risk for diabetes mellitus (p<0.001). Serotonin 59-68 5-hydroxytryptamine receptor 2C Homo sapiens 69-75 7663989-0 1995 Activation of glycogen phosphorylase by serotonin and 3,4-methylenedioxymethamphetamine in astroglial-rich primary cultures: involvement of the 5-HT2A receptor. Serotonin 40-49 glycogen phosphorylase L Rattus norvegicus 14-36 26234927-1 2015 BACKGROUND: Transient postnatal exposure of rodents to the selective serotonin (5-HT) reuptake inhibitor (SSRI) fluoxetine alters behavior and brain 5-HT neurotransmission during adulthood, and also reduces brain arachidonic (ARA) metabolic consumption and protein level of the ARA metabolizing enzyme, cytochrome P4504A (CYP4A). Serotonin 69-78 cytochrome P450, family 4, subfamily a, polypeptide 10 Mus musculus 303-309 26234927-1 2015 BACKGROUND: Transient postnatal exposure of rodents to the selective serotonin (5-HT) reuptake inhibitor (SSRI) fluoxetine alters behavior and brain 5-HT neurotransmission during adulthood, and also reduces brain arachidonic (ARA) metabolic consumption and protein level of the ARA metabolizing enzyme, cytochrome P4504A (CYP4A). Serotonin 69-78 cytochrome P450, family 4, subfamily a, polypeptide 10 Mus musculus 322-327 26538650-10 2015 Our findings demonstrate an instructive role for serotonin in axon guidance acting through ephrinB2a and reveal a novel mechanism for developmental interpretation of the environmental milieu in the generation of mature neural circuitry. Serotonin 49-58 ephrin-B2a Danio rerio 91-100 26151099-0 2015 The induction of Per1 expression by the combined treatment with glutamate, 5-hydroxytriptamine and dopamine initiates a ripple effect on Bmal1 and Cry1 mRNA expression via the ERK signaling pathway in cultured rat spinal astrocytes. Serotonin 75-94 aryl hydrocarbon receptor nuclear translocator-like Rattus norvegicus 137-142 7542063-2 1995 SCF, but not IL-4, induced low levels of serotonin release from mouse or rat peritoneal mast cells; rat mast cells acquired enhanced responsiveness to SCF during culture. Serotonin 41-50 kit ligand Mus musculus 0-3 25824009-11 2015 We show that genes that regulate serotonin signaling and action in the ovary are altered in prenatally FLX-exposed offspring, which when coupled with increased expression of components of the core Circadian Locomotor Output Cycles Kaput (CLOCK) gene regulatory loop may suggest an interaction between serotonergic signaling and clock gene signaling pathways leading to the altered reproductive phenotype. Serotonin 33-42 clock circadian regulator Rattus norvegicus 197-236 25824009-11 2015 We show that genes that regulate serotonin signaling and action in the ovary are altered in prenatally FLX-exposed offspring, which when coupled with increased expression of components of the core Circadian Locomotor Output Cycles Kaput (CLOCK) gene regulatory loop may suggest an interaction between serotonergic signaling and clock gene signaling pathways leading to the altered reproductive phenotype. Serotonin 33-42 clock circadian regulator Rattus norvegicus 238-243 25824009-11 2015 We show that genes that regulate serotonin signaling and action in the ovary are altered in prenatally FLX-exposed offspring, which when coupled with increased expression of components of the core Circadian Locomotor Output Cycles Kaput (CLOCK) gene regulatory loop may suggest an interaction between serotonergic signaling and clock gene signaling pathways leading to the altered reproductive phenotype. Serotonin 33-42 clock circadian regulator Rattus norvegicus 328-333 26224775-3 2015 Moderate AIH (mAIH; three 5-min episodes, PaO2 ~35-55 mmHG) elicits pLTF by a serotonin (5-HT)-dependent mechanism that requires new synthesis of brain-derived neurotrophic factor (BDNF), activation of its high-affinity receptor (TrkB), and ERK MAPK signaling. Serotonin 78-87 brain derived neurotrophic factor Homo sapiens 146-179 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Serotonin 230-239 C-C motif chemokine ligand 5 Homo sapiens 12-18 26038194-7 2015 Chemokines, RANTES/CCL5, MCP-1/CCL2, and related molecules, constitute the C-C class of chemokine supergene family, play a role in regulating T helper-cell cytokine production and MC trafficking, and are involved in histamine and serotonin generation and MC functions. Serotonin 230-239 C-C motif chemokine ligand 5 Homo sapiens 19-23 7617706-2 1995 The female TGF alpha mice showed elevated levels of norepinephrine (NE) in the hypothalamus and serotonin (5-HT) in the cortex and brain stem when compared with nontransgenic CD-1 females. Serotonin 96-105 transforming growth factor alpha Mus musculus 11-20 26192455-6 2015 In isolated PASMCs, hypoxia-induced BDNF increased intracellular Ca2+ responses to serotonin: an effect altered by HIF1alpha inhibition or by neutralization of extracellular BDNF via chimeric TrkB-Fc. Serotonin 83-92 brain derived neurotrophic factor Homo sapiens 36-40 26192455-6 2015 In isolated PASMCs, hypoxia-induced BDNF increased intracellular Ca2+ responses to serotonin: an effect altered by HIF1alpha inhibition or by neutralization of extracellular BDNF via chimeric TrkB-Fc. Serotonin 83-92 brain derived neurotrophic factor Homo sapiens 174-178 25732325-11 2015 Live calcium imaging indicates that serotonin inhibits spontaneous activity in abdominal LK neurons. Serotonin 36-45 Leucokinin Drosophila melanogaster 89-91 25732325-12 2015 Our results suggest that serotonin via 5-HT1B diminishes activity in the LK neurons and thereby modulates functions regulated by LK peptide, but the action of the dInR in these neurons remains less clear. Serotonin 25-34 Leucokinin Drosophila melanogaster 73-75 25732325-12 2015 Our results suggest that serotonin via 5-HT1B diminishes activity in the LK neurons and thereby modulates functions regulated by LK peptide, but the action of the dInR in these neurons remains less clear. Serotonin 25-34 Leucokinin Drosophila melanogaster 129-131 7887978-5 1995 The average increase in the rate of serotonin synthesis on the lesion side when compared with the contralateral side was between 3% (amygdala) and 52% (dorsal hippocampus; CA3 layer of hippocampus). Serotonin 36-45 carbonic anhydrase 3 Rattus norvegicus 172-175 25955598-1 2015 Tryptophan hydroxylase-2 (TPH2) contributes to alterations in the function of neuronal serotonin (5-HT), which are associated with various psychopathologies, including major depressive disorder (MDD) or suicidal behavior. Serotonin 87-96 tryptophan hydroxylase 2 Homo sapiens 0-24 25955598-1 2015 Tryptophan hydroxylase-2 (TPH2) contributes to alterations in the function of neuronal serotonin (5-HT), which are associated with various psychopathologies, including major depressive disorder (MDD) or suicidal behavior. Serotonin 87-96 tryptophan hydroxylase 2 Homo sapiens 26-30 25877746-1 2015 RATIONALE: 5-Hydroxytryptamine (5-HT) transport inhibitors can attenuate the abuse-related effects of cocaine, and the mechanisms underlying this attenuation may involve activation of 5-HT2C receptors. Serotonin 11-30 5-hydroxytryptamine receptor 2C Homo sapiens 184-190 25934037-8 2015 Together these findings further the notion that 5-HT6 signaling causes balanced activation of opposing MSN pathways by serotonin in sub-regions of the dorsal striatum allowing for more reflective modalities of behavior. Serotonin 119-128 5-hydroxytryptamine receptor 6 Rattus norvegicus 48-53 25934037-8 2015 Together these findings further the notion that 5-HT6 signaling causes balanced activation of opposing MSN pathways by serotonin in sub-regions of the dorsal striatum allowing for more reflective modalities of behavior. Serotonin 119-128 moesin Rattus norvegicus 103-106 25684064-0 2015 Integrin beta3 Haploinsufficiency Modulates Serotonin Transport and Antidepressant-Sensitive Behavior in Mice. Serotonin 44-53 integrin beta 3 Mus musculus 0-14 26705044-2 2015 METHODS: Expression levels of collagen I and lysyl oxidase (LOX) in osteoblast were measured by RT-PCR after treated by (50, 100, 200 and 400 ng/L) serotonin. Serotonin 148-157 lysyl oxidase Homo sapiens 60-63 26705044-5 2015 RESULTS: Serotonin promoted collagen I and LOX expression. Serotonin 9-18 lysyl oxidase Homo sapiens 43-46 26705044-7 2015 Furthermore, serotonin up-regulated the expression of Smad2 and Smad3 in osteoblasts, and the expression level of LOX was inhibited by Smad3 siRNA. Serotonin 13-22 lysyl oxidase Homo sapiens 114-117 26705044-8 2015 CONCLUSION: Serotonin promoted collagen I expression by activating Smads signaling pathway and up-regulating the LOX expression. Serotonin 12-21 lysyl oxidase Homo sapiens 113-116 25660244-8 2015 Moreover, exposure to IL-33 increased secretion of serotonin from allergen-challenged isolated airways. Serotonin 51-60 interleukin 33 Mus musculus 22-27 25660244-9 2015 In cultured mast cells, IL-33 enhanced the expression of tryptophan hydroxylase 1, serotonin synthesis, and storage, as well as the secretion of serotonin following IgE receptor cross-linking. Serotonin 83-92 interleukin 33 Mus musculus 24-29 25660244-9 2015 In cultured mast cells, IL-33 enhanced the expression of tryptophan hydroxylase 1, serotonin synthesis, and storage, as well as the secretion of serotonin following IgE receptor cross-linking. Serotonin 145-154 interleukin 33 Mus musculus 24-29 25660244-10 2015 CONCLUSION: These results demonstrate that IL-33 exacerbates allergic bronchoconstriction by increasing synthesis, storage, and secretion of serotonin from the mast cell. Serotonin 141-150 interleukin 33 Mus musculus 43-48 25966107-6 2015 Based on the gene expression profiles of the 8 types of liver cells, 5-hydroxytryptamine promoted hepatocyte proliferation through the RAS and STAT3 signaling pathways, proliferation and differentiation of sinusoidal endothelial cells through the STAT3 signaling pathway, and proliferation and apoptosis of pit cells through the AKT3 signaling pathway. Serotonin 69-88 AKT serine/threonine kinase 3 Rattus norvegicus 329-333 25637699-4 2015 Alpha-synuclein oligomers were quantified by western blotting after incubation of alpha-synuclein with serotonin and monoamine oxidase-A (MAO-A) to generate 5-HIAL or dopamine to generate DOPAL. Serotonin 103-112 synuclein alpha Rattus norvegicus 0-15 25637699-4 2015 Alpha-synuclein oligomers were quantified by western blotting after incubation of alpha-synuclein with serotonin and monoamine oxidase-A (MAO-A) to generate 5-HIAL or dopamine to generate DOPAL. Serotonin 103-112 synuclein alpha Rattus norvegicus 82-97 25774879-9 2015 These web tools revealed that hepatocyte nuclear factor 4 alpha (Hnf4a) may exert direct effects on various genes specifically associated with amine synthesis, such as genes involved in serotonin metabolism and related immunological functions. Serotonin 186-195 hepatic nuclear factor 4, alpha Mus musculus 30-63 25774879-9 2015 These web tools revealed that hepatocyte nuclear factor 4 alpha (Hnf4a) may exert direct effects on various genes specifically associated with amine synthesis, such as genes involved in serotonin metabolism and related immunological functions. Serotonin 186-195 hepatic nuclear factor 4, alpha Mus musculus 65-70 25666387-1 2015 Serotonin 5-HT2B receptor antagonists have been proposed as migraine prophylactic drugs, but previously available 5-HT2B receptor antagonists displayed multiple monoaminergic side effects and had to be withdrawn from the market. Serotonin 0-9 5-hydroxytryptamine receptor 2B Cavia porcellus 10-16 25542888-6 2015 Tryptophan hydroxylase 1 (TPH1) and monoamine oxidase (MAO), two important rate-limiting enzymes in serotonin synthesis and metabolic process respectively, were detected. Serotonin 100-109 tryptophan hydroxylase 1 Rattus norvegicus 0-24 25542888-6 2015 Tryptophan hydroxylase 1 (TPH1) and monoamine oxidase (MAO), two important rate-limiting enzymes in serotonin synthesis and metabolic process respectively, were detected. Serotonin 100-109 tryptophan hydroxylase 1 Rattus norvegicus 26-30 25716782-5 2015 Supporting these differences to be important for the behavioral differences, serotonin depletion obtained by the tryptophan hydroxylase-2 inhibitor p-chlorophenylalanine eliminated them by reducing anxiety in "anxious" but not "non-anxious" rats. Serotonin 77-86 tryptophan hydroxylase 2 Rattus norvegicus 113-137 25120077-5 2015 With blonanserin, both of these effects were antagonized by DOI (a serotonin 5-HT2A receptor agonist) and 7-OH-DPAT (a dopamine-D3 receptor agonist), whereas the effects of olanzapine were antagonized by DOI but not by 7-OH-DPAT. Serotonin 67-76 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 77-83 25542858-2 2015 Lack of response could be due to inhibition of dopamine (DA) release by serotonin (5-HT) through 5-HT2C receptors. Serotonin 72-81 5-hydroxytryptamine receptor 2C Homo sapiens 97-103 25448824-1 2015 5-HT2c G-protein coupled receptors located in the central nervous system bind the endogenous neurotransmitters serotonin and couple to G protein to mediate excitatory neurotransmission, which inhibits dopamine and norepinephrine release in the brain. Serotonin 111-120 5-hydroxytryptamine receptor 2C Rattus norvegicus 0-6 25217810-8 2015 Serotonin interacts within the hypothalamus with endogenous orexigenic (Neuropeptide Y/Agouti related protein) and anorectic (alpha-melanocyte stimulating hormone) peptides. Serotonin 0-9 agouti related neuropeptide Homo sapiens 87-109 26630956-4 2015 Several FAAH or MAGL inhibitors are reported to have no cannabimimetic side effects and, therefore, are new potential therapeutic options for patients with MDD who are resistant to first-line antidepressants (selective serotonin and serotonin-norepinephrine reuptake inhibitors). Serotonin 219-228 monoglyceride lipase Homo sapiens 16-20 26630956-4 2015 Several FAAH or MAGL inhibitors are reported to have no cannabimimetic side effects and, therefore, are new potential therapeutic options for patients with MDD who are resistant to first-line antidepressants (selective serotonin and serotonin-norepinephrine reuptake inhibitors). Serotonin 233-242 monoglyceride lipase Homo sapiens 16-20 26630961-0 2015 An Endogenous Tachykinergic NK2/NK3 Receptor Cascade System Controlling the Release of Serotonin from Colonic Mucosa. Serotonin 87-96 neuromedin-K receptor Cavia porcellus 32-44 25220079-0 2015 BDNF Val66met and 5-HTTLPR polymorphisms predict a human in vivo marker for brain serotonin levels. Serotonin 82-91 brain derived neurotrophic factor Homo sapiens 0-4 25220079-1 2015 Brain-derived neurotrophic factor (BDNF) has been implicated in multiple aspects of brain function including regulation of serotonin signaling. Serotonin 123-132 brain derived neurotrophic factor Homo sapiens 0-33 25220079-1 2015 Brain-derived neurotrophic factor (BDNF) has been implicated in multiple aspects of brain function including regulation of serotonin signaling. Serotonin 123-132 brain derived neurotrophic factor Homo sapiens 35-39 25220079-2 2015 The BDNF val66met polymorphism (rs6265) has been linked to aspects of serotonin signaling in humans but its effects are not well understood. Serotonin 70-79 brain derived neurotrophic factor Homo sapiens 4-8 25220079-9 2015 Our findings indicate that BDNF val66met significantly predicts a common regulator of brain [11C]SB207145 binding, which we hypothesize reflects brain serotonin levels. Serotonin 151-160 brain derived neurotrophic factor Homo sapiens 27-31 25220079-11 2015 These findings implicate serotonin signaling as an important molecular mediator underlying the effects of BDNF val66met and 5-HTTLPR on behavior and related risk for neuropsychiatric illness in humans. Serotonin 25-34 brain derived neurotrophic factor Homo sapiens 106-110 25347540-2 2014 In light of evidence for biological connections between BDNF and serotonin, it is prudent to consider genetic epistasis between variants in these genes in the development of depressive symptoms. Serotonin 65-74 brain derived neurotrophic factor Homo sapiens 56-60 25314256-1 2014 BACKGROUND: The serotonin toxicity syndrome (STS) is a potential risk with concurrent use of the monoamine oxidase type-B inhibitor rasagiline and antidepressants. Serotonin 16-25 monoamine oxidase B Homo sapiens 97-121 25250906-6 2014 Interestingly, AtCOMT can methylate serotonin into 5-MT with low catalytic activity (Km , 3.396 mm; Vmax , 528 pmol/min/mg protein). Serotonin 36-45 O-methyltransferase 1 Arabidopsis thaliana 15-21 25250906-7 2014 These data suggest that serotonin can be converted into either N-acetylserotonin by SNAT or into 5-MT by COMT, after which it is metabolized into melatonin by COMT or SNAT, respectively. Serotonin 24-33 O-methyltransferase 1 Arabidopsis thaliana 105-109 25250906-7 2014 These data suggest that serotonin can be converted into either N-acetylserotonin by SNAT or into 5-MT by COMT, after which it is metabolized into melatonin by COMT or SNAT, respectively. Serotonin 24-33 O-methyltransferase 1 Arabidopsis thaliana 159-163 25250906-8 2014 To support this hypothesis, serotonin was incubated in the presence of both AtSNAT and AtCOMT enzymes. Serotonin 28-37 O-methyltransferase 1 Arabidopsis thaliana 87-93 24917195-0 2014 Prevention of alcohol-heightened aggression by CRF-R1 antagonists in mice: critical role for DRN-PFC serotonin pathway. Serotonin 101-110 corticotropin releasing hormone receptor 1 Mus musculus 47-53 24917195-3 2014 The serotonin (5-HT) pathway from the dorsal raphe nucleus (DRN) to the medial prefrontal cortex (mPFC) by CRF-R1 was investigated as a possible target for the prevention of alcohol-heightened aggressive behavior. Serotonin 4-13 corticotropin releasing hormone receptor 1 Mus musculus 107-113 25332063-1 2014 BACKGROUND: The novel antidepressant agomelatine, a melatonergic MT1/MT2 agonist combined with 5-HT2c serotonin antagonist properties, showed antidepressant action in preclinical and clinical studies. Serotonin 102-111 5-hydroxytryptamine receptor 2C Rattus norvegicus 95-101 24752421-6 2014 The glucuronides of estradiol, imipramine, serotonin, propofol, 3"-azido-3"-deoxythymidine (AZT) and morphine, selective substrates of human UGT1A1, 1A4, 1A6, 1A9 and 2B7 (AZT and morphine), respectively, were measured using LC-MS/MS. Serotonin 43-52 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 141-147 24899127-1 2014 Human TPH2 (hTPH2) catalyzes the rate-limiting step in CNS serotonin biosynthesis. Serotonin 59-68 tryptophan hydroxylase 2 Homo sapiens 6-10 24899127-1 2014 Human TPH2 (hTPH2) catalyzes the rate-limiting step in CNS serotonin biosynthesis. Serotonin 59-68 tryptophan hydroxylase 2 Homo sapiens 12-17 24881576-5 2014 We demonstrate that PEX13 brain mutants display changes that reflect an abnormal serotonergic system - decreased levels of tryptophan hydroxylase-2, the rate-limiting enzyme of serotonin (5-hydroxytryptamine, 5-HT) synthesis, dysmorphic 5-HT-positive neurons, abnormal distribution of 5-HT neurons, and dystrophic serotonergic axons. Serotonin 177-186 peroxisomal biogenesis factor 13 Mus musculus 20-25 24881576-5 2014 We demonstrate that PEX13 brain mutants display changes that reflect an abnormal serotonergic system - decreased levels of tryptophan hydroxylase-2, the rate-limiting enzyme of serotonin (5-hydroxytryptamine, 5-HT) synthesis, dysmorphic 5-HT-positive neurons, abnormal distribution of 5-HT neurons, and dystrophic serotonergic axons. Serotonin 188-207 peroxisomal biogenesis factor 13 Mus musculus 20-25 25089244-1 2014 Tryptophan hydroxylase (TPH) catalyses l-tryptophan into 5-hydroxy-l-tryptophan, which is the first and rate-limiting step of serotonin (5-HT) biosynthesis. Serotonin 126-135 tryptophan hydroxylase 1 Rattus norvegicus 0-22 25089244-1 2014 Tryptophan hydroxylase (TPH) catalyses l-tryptophan into 5-hydroxy-l-tryptophan, which is the first and rate-limiting step of serotonin (5-HT) biosynthesis. Serotonin 126-135 tryptophan hydroxylase 1 Rattus norvegicus 24-27 25089244-1 2014 Tryptophan hydroxylase (TPH) catalyses l-tryptophan into 5-hydroxy-l-tryptophan, which is the first and rate-limiting step of serotonin (5-HT) biosynthesis. Serotonin 137-141 tryptophan hydroxylase 1 Rattus norvegicus 0-22 25089244-1 2014 Tryptophan hydroxylase (TPH) catalyses l-tryptophan into 5-hydroxy-l-tryptophan, which is the first and rate-limiting step of serotonin (5-HT) biosynthesis. Serotonin 137-141 tryptophan hydroxylase 1 Rattus norvegicus 24-27 25089244-9 2014 Interactions with these residues may critically regulate TPH function and thus serotonin synthesis. Serotonin 79-88 tryptophan hydroxylase 1 Rattus norvegicus 57-60 24710314-3 2014 Evidence has suggested that nNOS inhibition increases serotonin signaling in the brain. Serotonin 54-63 nitric oxide synthase 1 Rattus norvegicus 28-32 24583042-5 2014 The increased serotonin causes a decrease of oxytocin in the paraventricular nucleus of the hypothalamus and an increase in calcitonin gene-related peptide (CGRP) in the central nucleus of the amygdale, which are associated with social interactions and vital in autism. Serotonin 14-23 oxytocin/neurophysin I prepropeptide Homo sapiens 45-53 24802806-7 2014 Based on preclinical studies, certain serotonin (5-HT) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-HT receptors acting at 5-HT1A, 5-HT4 and 5-HT6 receptors. Serotonin 38-47 5-hydroxytryptamine receptor 4 Homo sapiens 197-222 24802806-7 2014 Based on preclinical studies, certain serotonin (5-HT) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-HT receptors acting at 5-HT1A, 5-HT4 and 5-HT6 receptors. Serotonin 49-53 5-hydroxytryptamine receptor 4 Homo sapiens 197-222 24802806-7 2014 Based on preclinical studies, certain serotonin (5-HT) receptor ligands have been suggested to have the ability to modify or improve memory/cognition, specifically 5-HT receptors acting at 5-HT1A, 5-HT4 and 5-HT6 receptors. Serotonin 164-168 5-hydroxytryptamine receptor 4 Homo sapiens 197-222 24451568-0 2014 Pharmacological characterization of BDNF promoters I, II and IV reveals that serotonin and norepinephrine input is sufficient for transcription activation. Serotonin 77-86 brain-derived neurotrophic factor Rattus norvegicus 36-40 24650663-0 2014 Effects of serotonin on expression of the LDL receptor family member LR11 and 7-ketocholesterol-induced apoptosis in human vascular smooth muscle cells. Serotonin 11-20 sortilin related receptor 1 Homo sapiens 69-73 24442491-6 2014 In the duodenum and jejunum, TRPA1 occurred in EEC that contained both cholecystokinin (CCK) and 5-hydroxytryptamine (5HT) and in a small number of cells expressing 5HT but not CCK. Serotonin 97-116 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 29-34 24442491-6 2014 In the duodenum and jejunum, TRPA1 occurred in EEC that contained both cholecystokinin (CCK) and 5-hydroxytryptamine (5HT) and in a small number of cells expressing 5HT but not CCK. Serotonin 118-121 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 29-34 24375143-11 2014 The enzyme showed low activity for 5-aminosalicylic acid and 5-hydroxytryptamine, which are reported as good substrates of a known arylamine N-acetyltransferase and an arylalkylamine N-acetyltransferase. Serotonin 61-80 aralkylamine N-acetyltransferase Homo sapiens 168-202 24525204-4 2014 RESULTS: In vitro tracer uptake in endocrine cells (INS-1 and human islets), but not PANC1 and exocrine cells, was mediated specifically by intracellular conversion into serotonin. Serotonin 170-179 forkhead box M1 Homo sapiens 52-57 24239560-8 2014 Furthermore, HPLC analyses revealed that Cnr1/Gad1 mice have enhanced serotonin levels, but not dopamine levels in response to amphetamine. Serotonin 70-79 glutamate decarboxylase 1 Mus musculus 46-50 26491607-11 2014 Other significant predictors of BDNF levels at the last visit included receiving selective serotonin reuptake inhibitors and PPP serotonin levels. Serotonin 91-100 brain derived neurotrophic factor Homo sapiens 32-36 26491607-11 2014 Other significant predictors of BDNF levels at the last visit included receiving selective serotonin reuptake inhibitors and PPP serotonin levels. Serotonin 129-138 brain derived neurotrophic factor Homo sapiens 32-36 24493647-3 2014 Here we report that compounds activating serotonin (5HT) subtype 2B receptors (5HT2B-Rs) or dopamine (DA) subtype 1-like receptors (D1-Rs) and/or those inhibiting 5HT2A-Rs or D2-Rs moderately enhance Ras-PI3K/PKB signaling input, GluA1-dependent synaptic plasticity, and learning in Fmr1 knockout mice. Serotonin 41-50 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 79-84 24493647-4 2014 Unexpectedly, combinations of these 5HT and DA compounds at low doses synergistically stimulate Ras-PI3K/PKB signal transduction and GluA1-dependent synaptic plasticity and remarkably restore normal learning in Fmr1 knockout mice without causing anxiety-related side effects. Serotonin 36-39 fragile X messenger ribonucleoprotein 1 Mus musculus 211-215 24333411-6 2014 High dose CORT exposure significantly increased platelet serotonin (5-HT) uptake, decreased whole blood 5-HT concentration (p<0.05), downregulated hypothalamic tryptophan hydroxylase 1 (TPH1) mRNA and upregulated 5-HT receptor 1A (5-HTR1A) and monoamine oxidase A (MAO-A) mRNA, but not monoamine oxidase B (MAO-B). Serotonin 57-66 CORT Gallus gallus 10-14 24316738-4 2014 VMAT2-controlled monoamines, such as dopamine, histamine and serotonin, negatively regulated beta-cell differentiation. Serotonin 61-70 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 0-5 24664769-7 2014 We have now shown that TrkB activation in the retina and hippocampus is circadian in C3H/f(+/+) mice, which synthesize NAS, but not in C57BL/6 mice, which have a mutation in the gene encoding the enzyme that converts serotonin to NAS. Serotonin 217-226 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 23-27 24649064-0 2014 Serotonin induces the migration of PC12 cells via the serotonin receptor 6/cAMP/ERK pathway. Serotonin 0-9 5-hydroxytryptamine receptor 6 Rattus norvegicus 54-74 24369991-6 2013 Additionally, the mechanisms involved in the antidepressant-like action of MAK were investigated by the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP)- or 5-HT2A agonist (+-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI)-induced head twitch responses. Serotonin 104-113 male germ cell-associated kinase Rattus norvegicus 75-78 24336234-0 2013 Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase. Serotonin 0-9 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 126-129 23990339-8 2013 Meanwhile, the anti-inflammatory IL-10 may exert a neuroprotective effect and prevent the putative reduced capacity for 5-hydroxytryptamine synthesis in the brain. Serotonin 120-139 interleukin 10 Homo sapiens 33-38 24223727-7 2013 Moreover, serotonin released from the ADF sensory neurons might act through the G-protein-coupled serotonin receptors of SER-4 and SER-7 to regulate the thermotaxis memory behavior. Serotonin 10-19 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 131-136 24024533-3 2013 S100B is a glia-derived calcium-binding protein, which may influence the development of serotonergic fibers and, vice versa, serotonin may influence the expression of S100B. Serotonin 125-134 S100 calcium binding protein B Rattus norvegicus 167-172 23964727-6 2013 Serotonin, in turn, could bind to HTR1B receptors on osteoblasts and stop their proliferation by activating PKA and CREB.Although different groups have reported controversial results on the existence of an Lrp5-serotonin axis and the action of serotonin in bone remodeling, there is convincing evidence that serotonin modulators such as SSRIs can affect bone turnover. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 34-39 23628433-3 2013 Therefore, in the present study we investigate the association of TPH2, the rate limiting enzyme in 5-HT biosynthesis and ITGB3, a serotonin quantitative trait locus with ASD in the Indian population. Serotonin 131-140 tryptophan hydroxylase 2 Homo sapiens 66-70 24265583-1 2013 In this study, we investigated the association between tryptophan hydroxylase-1 (TPH1 ) (218A>C), tryptophan hydroxylase-2 ( TPH2 ) (1463G>A) and serotonin carrier family 6, member 4 (SLC6A4) [long (L) vs. short (S)] gene polymorphisms with post-partum depression (PPD) in women from Jordan. Serotonin 152-161 tryptophan hydroxylase 2 Homo sapiens 101-125 24265583-1 2013 In this study, we investigated the association between tryptophan hydroxylase-1 (TPH1 ) (218A>C), tryptophan hydroxylase-2 ( TPH2 ) (1463G>A) and serotonin carrier family 6, member 4 (SLC6A4) [long (L) vs. short (S)] gene polymorphisms with post-partum depression (PPD) in women from Jordan. Serotonin 152-161 tryptophan hydroxylase 2 Homo sapiens 128-132 23337130-9 2013 The interaction observed between the associated polymorphisms, could indicate that there is a biological interaction between the serotonin (TPH2 and SLC18A1) and glutamate (GRIA3) pathways and the factors related to neurogenesis (CDH9, OLIG2 and NTRK3) for the explanation of etiopathophysiology in both diseases. Serotonin 129-138 tryptophan hydroxylase 2 Homo sapiens 140-144 23337130-9 2013 The interaction observed between the associated polymorphisms, could indicate that there is a biological interaction between the serotonin (TPH2 and SLC18A1) and glutamate (GRIA3) pathways and the factors related to neurogenesis (CDH9, OLIG2 and NTRK3) for the explanation of etiopathophysiology in both diseases. Serotonin 129-138 cadherin 9 Homo sapiens 230-234 23337130-9 2013 The interaction observed between the associated polymorphisms, could indicate that there is a biological interaction between the serotonin (TPH2 and SLC18A1) and glutamate (GRIA3) pathways and the factors related to neurogenesis (CDH9, OLIG2 and NTRK3) for the explanation of etiopathophysiology in both diseases. Serotonin 129-138 neurotrophic receptor tyrosine kinase 3 Homo sapiens 246-251 23353550-10 2013 We find that addition of exogenous 5HT to ascl1a-/- embryos at near physiological levels (measured by differential pulse voltammetry) induce anterograde motility at similar levels to wild type velocity, distance, and frequency. Serotonin 35-38 achaete-scute family bHLH transcription factor 1a Danio rerio 42-48 23333670-0 2013 c-Fos activity mapping reveals differential effects of noradrenaline and serotonin depletion on the regulation of ocular dominance plasticity in rats. Serotonin 73-82 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 23333670-3 2013 Applying this new method, here we studied the unique modification of the degree of c-Fos expression induced in the visual cortex, in that endogenous noradrenaline (NA) and serotonin (5HT) in the cortex were significantly reduced, respectively by specific pharmacological agents. Serotonin 172-181 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 83-88 23333670-3 2013 Applying this new method, here we studied the unique modification of the degree of c-Fos expression induced in the visual cortex, in that endogenous noradrenaline (NA) and serotonin (5HT) in the cortex were significantly reduced, respectively by specific pharmacological agents. Serotonin 183-186 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 83-88 23502536-3 2013 We found that endogenous serotonin selectively potentiated excitatory synapses formed by the temporoammonic pathway with CA1 pyramidal cells via activation of serotonin receptors (5-HT(1B)Rs), without affecting nearby Schaffer collateral synapses. Serotonin 25-34 5-hydroxytryptamine receptor 1B Rattus norvegicus 180-187 23532449-5 2013 Recent pharmacological and biochemical studies point toward altered function of GABA-, 5-hydroxytryptamine-, and dopaminergic systems in Lsamp-deficient mice. Serotonin 87-106 limbic system-associated membrane protein Mus musculus 137-142 23355731-3 2013 5HT inhibited the LPS-induced release of proinflammatory cytokines without affecting IL-10 production, upregulated the expression of M2 polarization-associated genes (SERPINB2, THBS1, STAB1, COL23A1), and reduced the expression of M1-associated genes (INHBA, CCR2, MMP12, SERPINE1, CD1B, ALDH1A2). Serotonin 0-3 stabilin 1 Homo sapiens 184-189 23355731-3 2013 5HT inhibited the LPS-induced release of proinflammatory cytokines without affecting IL-10 production, upregulated the expression of M2 polarization-associated genes (SERPINB2, THBS1, STAB1, COL23A1), and reduced the expression of M1-associated genes (INHBA, CCR2, MMP12, SERPINE1, CD1B, ALDH1A2). Serotonin 0-3 matrix metallopeptidase 12 Homo sapiens 265-270 23355731-3 2013 5HT inhibited the LPS-induced release of proinflammatory cytokines without affecting IL-10 production, upregulated the expression of M2 polarization-associated genes (SERPINB2, THBS1, STAB1, COL23A1), and reduced the expression of M1-associated genes (INHBA, CCR2, MMP12, SERPINE1, CD1B, ALDH1A2). Serotonin 0-3 aldehyde dehydrogenase 1 family member A2 Homo sapiens 288-295 23390589-5 2013 The released serotonin activates the feeding response mainly by acting humorally and directly activates SER-7, a type 7 serotonin receptor, in MC motor neurons in the feeding organ. Serotonin 13-22 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 104-109 23174863-8 2013 Expression of 5-hydroxytryptamine (5-HT) and its synthesizing enzyme tryptophan hydroxylase (TPH) in the dorsal raphe was increased compared with unstressed rats. Serotonin 14-33 tryptophan hydroxylase 1 Rattus norvegicus 69-91 23174863-8 2013 Expression of 5-hydroxytryptamine (5-HT) and its synthesizing enzyme tryptophan hydroxylase (TPH) in the dorsal raphe was increased compared with unstressed rats. Serotonin 14-33 tryptophan hydroxylase 1 Rattus norvegicus 93-96 23157625-2 2013 BDNF is also believed to interact with other neurotransmitter systems implicated in schizophrenia, such as dopamine, glutamate, serotonin and GABA. Serotonin 128-137 brain derived neurotrophic factor Homo sapiens 0-4 21898033-6 2012 The present study aims to examine the association between three common BDNF single-nucleotid polymorphisms (SNPs; rs7103411, rs7124442, and rs6265) and depressive symptoms in a community-based elderly population taking into account the serum levels of four neurotransmitters, serotonin, dopamine, adrenalin, and noradrenalin, as potential mediating factors. Serotonin 276-285 brain derived neurotrophic factor Homo sapiens 71-75 22961814-1 2012 Serotonin-1B (5-HT(1B) ) autoreceptors are located in serotonin (5-HT) terminals, along with serotonin transporters (SERT), and play a critical role in autoregulation of serotonergic neurotransmission and are implicated in disorders of serotonergic function, particularly emotional regulation. Serotonin 54-63 5-hydroxytryptamine receptor 1B Rattus norvegicus 14-21 22961814-9 2012 Because SERT clearance rate varies as a function of 5-HT(1B) autoreceptor expression levels and is modulated by both activation and inhibition of 5-HT(1B) autoreceptors, this dynamic interaction may be an important mechanism of serotonin autoregulation with therapeutic implications. Serotonin 228-237 5-hydroxytryptamine receptor 1B Rattus norvegicus 52-59 22961814-9 2012 Because SERT clearance rate varies as a function of 5-HT(1B) autoreceptor expression levels and is modulated by both activation and inhibition of 5-HT(1B) autoreceptors, this dynamic interaction may be an important mechanism of serotonin autoregulation with therapeutic implications. Serotonin 228-237 5-hydroxytryptamine receptor 1B Rattus norvegicus 146-153 26593027-1 2012 Monoamine oxidase (MAO), which exists in two isozymic forms, MAO A and MAO B, is an important flavoenzyme responsible for the metabolism of amine neurotransmitters such as dopamine, serotonin, and norepinephrine. Serotonin 182-191 monoamine oxidase B Homo sapiens 71-76 22454242-3 2012 We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain. Serotonin 70-79 D-amino acid oxidase activator Homo sapiens 21-25 23019496-1 2012 The human serotonin transporter (hSERT), the human dopamine transporter (hDAT), and the human norepinephrine transporter (hNET) facilitate the active uptake of the neurotransmitters serotonin, dopamine, and norepinephrine from the synaptic cleft. Serotonin 10-19 solute carrier family 6 member 3 Homo sapiens 51-71 22826348-0 2012 Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade. Serotonin 103-112 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 39-62 22721547-2 2012 The aim of this study was to investigate whether genetic polymorphisms in the TPH2 gene, the gene product of which is the rate-limiting enzyme in the biosynthesis of serotonin in the central nervous system, are associated with depressive symptoms in pregnancy and the postpartum period. Serotonin 166-175 tryptophan hydroxylase 2 Homo sapiens 78-82 22826223-7 2012 This increment of Tph2 was accompanied by increases in the levels of total serotonin in vitro. Serotonin 75-84 tryptophan hydroxylase 2 Rattus norvegicus 18-22 22826223-8 2012 Moreover, the MIF receptor CD74 and the ERK1/2 pathway mediate the MIF-induced Tph2 and Bdnf gene expression as well as serotonin content. Serotonin 120-129 CD74 molecule Rattus norvegicus 27-31 22297159-0 2012 A link between oxytocin and serotonin in humans: supporting evidence from peripheral markers. Serotonin 28-37 oxytocin/neurophysin I prepropeptide Homo sapiens 15-23 22297159-2 2012 In particular, some selective serotonin (5-HT) reuptake inhibitors, such as citalopram and fluvoxamine, seem to exert part of their antidepressant effects through oxytocin (OT) release. Serotonin 30-39 oxytocin/neurophysin I prepropeptide Homo sapiens 163-171 22297159-2 2012 In particular, some selective serotonin (5-HT) reuptake inhibitors, such as citalopram and fluvoxamine, seem to exert part of their antidepressant effects through oxytocin (OT) release. Serotonin 30-39 oxytocin/neurophysin I prepropeptide Homo sapiens 173-175 22739376-7 2012 Dopamine (DA) receptor D1 was upregulated in the hippocampus of Fe+DHA/EPA rats (fold-change = 1.25; P < 0.05) and there were significant Fe x DHA/EPA interactions on serotonin (5-HT) in the OB and on the DA metabolite dihydroxyphenylacetic acid in the FC and striatum. Serotonin 170-179 dopamine receptor D1 Rattus norvegicus 0-25 22764241-2 2012 Serotonin 2C (5-HT(2C)) receptors mediate the inhibitory effects of serotonin on dopaminergic circuitry in experimental animals, and preclinical findings have implicated 5-HT(2C) receptors in motivated behaviors and psychotropic drug mechanisms. Serotonin 68-77 5-hydroxytryptamine receptor 2C Homo sapiens 14-22 22764241-2 2012 Serotonin 2C (5-HT(2C)) receptors mediate the inhibitory effects of serotonin on dopaminergic circuitry in experimental animals, and preclinical findings have implicated 5-HT(2C) receptors in motivated behaviors and psychotropic drug mechanisms. Serotonin 68-77 5-hydroxytryptamine receptor 2C Homo sapiens 170-178 22404309-3 2012 We found that noggin, a known antagonist of bone morphogenic protein, induces ES cells to express genes involved in serotonergic differentiation, such as Nkx2.2, Pet-1, Sonic hedgehog, tryptophan hydroxylase 2, and serotonin transporter, as well as increases high potassium-induced release of serotonin. Serotonin 215-224 noggin Mus musculus 14-20 23204981-0 2012 Immunomodulation Mechanism of Antidepressants: Interactions between Serotonin/Norepinephrine Balance and Th1/Th2 Balance. Serotonin 68-77 negative elongation factor complex member C/D Homo sapiens 105-108 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase B Homo sapiens 37-56 22890201-2 2012 Both monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) regulate neurochemistry by degrading monoamine neurotransmitters (serotonin, dopamine, and norepinephrine). Serotonin 131-140 monoamine oxidase B Homo sapiens 58-63 22436011-6 2012 By targeting the tetanus toxin light chain (TNT) and the human inwardly rectifying potassium channel (Kir2.1) to the serotonin neurons with two different GAL4 driver combinations, the serotonergic system was inhibited. Serotonin 117-126 galectin 4 Homo sapiens 154-158 22318196-8 2012 In cultured hippocampal neurons, application of serotonin or norepinephrine (10-50 muM) induced increase in synaptic transmission and targeting of BDNF mRNA in dendrites. Serotonin 48-57 brain derived neurotrophic factor Homo sapiens 147-151 22365943-4 2012 Patients who lack both MAOA and MAOB have the most extreme laboratory values (urine, blood, and CSF serotonin 4-6 times normal, with elevated O-methylated amine metabolites and reduced deaminated metabolites) in addition to severe intellectual deficiency and behavioral problems. Serotonin 100-109 monoamine oxidase B Homo sapiens 32-36 22328573-6 2012 In vivo effects of PDE9A inhibition included reversal of the respective disruptions of working memory by ketamine, episodic and spatial memory by scopolamine, and auditory gating by amphetamine, as well as potentiation of risperidone-induced improvements in sensorimotor gating and reversal of the stereotypic scratching response to the hallucinogenic 5-hydroxytryptamine 2A agonist mescaline. Serotonin 352-371 phosphodiesterase 9A Homo sapiens 19-24 22428927-6 2012 The upregulation was partially suppressed by treatment with 5-HT2A agonists (serotonin and alpha-Me-5-HT), suggesting that safflomide may upregulate adiponectin expression more than by blocking 5-HT2A receptors in 3T3-L1 cells. Serotonin 77-86 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 60-66 21947356-5 2012 Pre-perfusion with CRF1 antagonist into DRN inhibited 0.1 muM CRF-induced serotonin reduction, whereas pre-perfusion with CRF2 antagonist in DRN inhibited 10 muM CRF-induced serotonin elevation, without affecting 0.1 muM CRF-induced serotonin reduction. Serotonin 74-83 corticotropin releasing hormone receptor 1 Rattus norvegicus 19-23 21947356-5 2012 Pre-perfusion with CRF1 antagonist into DRN inhibited 0.1 muM CRF-induced serotonin reduction, whereas pre-perfusion with CRF2 antagonist in DRN inhibited 10 muM CRF-induced serotonin elevation, without affecting 0.1 muM CRF-induced serotonin reduction. Serotonin 174-183 corticotropin releasing hormone receptor 2 Rattus norvegicus 122-126 21947356-5 2012 Pre-perfusion with CRF1 antagonist into DRN inhibited 0.1 muM CRF-induced serotonin reduction, whereas pre-perfusion with CRF2 antagonist in DRN inhibited 10 muM CRF-induced serotonin elevation, without affecting 0.1 muM CRF-induced serotonin reduction. Serotonin 174-183 corticotropin releasing hormone receptor 2 Rattus norvegicus 122-126 21947356-8 2012 Pre-perfusion with sub-therapeutic concentration LTG inhibited CRF1-induced serotonin reduction without affecting CRF2-induced serotonin release, whereas pre-perfusion with therapeutic concentration of LTG inhibited both CRF1- and CRF2-actions. Serotonin 76-85 corticotropin releasing hormone receptor 1 Rattus norvegicus 63-67 22460157-5 2012 Also, most of the commonly used DAT tracers bind not only to striatal DATs, but to serotonin transporters in extrastriatal brain areas as well. Serotonin 83-92 solute carrier family 6 member 3 Homo sapiens 32-35 21976671-2 2012 Previously we reported a deficiency of serotonin (5-HT) and its key biosynthetic enzyme, tryptophan hydroxylase (TPH2), in SIDS infants in the medullary 5-HT system that modulates homeostatic responses during sleep. Serotonin 39-48 tryptophan hydroxylase 2 Homo sapiens 113-117 23406739-1 2012 While a recent study has reported that early citalopram exposure alters cortical network function and produces autistic-like behaviors in male rats, when evaluating antidepressant animal models of autism spectrum disorder (ASD) it is important to note that some selective serotonin (5-HT) reuptake inhibitors alter 3alpha-hydroxysteroid dehydrogenase activity, and thus steroidogenesis. Serotonin 272-281 aldo-keto reductase family 1, member C14 Rattus norvegicus 315-350 22693556-1 2012 BACKGROUND: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Serotonin 107-116 tryptophan hydroxylase 2 Homo sapiens 12-36 22693556-1 2012 BACKGROUND: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Serotonin 107-116 tryptophan hydroxylase 2 Homo sapiens 38-42 22693556-1 2012 BACKGROUND: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Serotonin 169-178 tryptophan hydroxylase 2 Homo sapiens 12-36 22693556-1 2012 BACKGROUND: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Serotonin 169-178 tryptophan hydroxylase 2 Homo sapiens 38-42 21814181-0 2011 Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Serotonin 7-16 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 61-94 21814181-0 2011 Severe serotonin depletion after conditional deletion of the vesicular monoamine transporter 2 gene in serotonin neurons: neural and behavioral consequences. Serotonin 103-112 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 61-94 21814181-1 2011 The vesicular monoamine transporter type 2 gene (VMAT2) has a crucial role in the storage and synaptic release of all monoamines, including serotonin (5-HT). Serotonin 140-149 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 49-54 21763405-2 2011 In macaques, ovarian steroid administration to ovariectomized (Ovx) individuals improves serotonin neural function through actions on pivotal serotonin-related genes and proteins, such as TPH2 (tryptophan hydroxylase 2), SERT (serotonin reuptake transporter), and the 5HT1A autoreceptor. Serotonin 89-98 tryptophan hydroxylase 2 Homo sapiens 188-192 21763405-2 2011 In macaques, ovarian steroid administration to ovariectomized (Ovx) individuals improves serotonin neural function through actions on pivotal serotonin-related genes and proteins, such as TPH2 (tryptophan hydroxylase 2), SERT (serotonin reuptake transporter), and the 5HT1A autoreceptor. Serotonin 89-98 tryptophan hydroxylase 2 Homo sapiens 194-218 21740969-1 2011 We sought to develop a mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model to characterize the effects of ginsenoside Rb1 (Rb1) and estradiol (E(2)) on neural 5-hydroxytryptamine (5-HT) concentration in ovariectomized mice. Serotonin 169-188 RB transcriptional corepressor 1 Mus musculus 128-131 21740969-1 2011 We sought to develop a mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model to characterize the effects of ginsenoside Rb1 (Rb1) and estradiol (E(2)) on neural 5-hydroxytryptamine (5-HT) concentration in ovariectomized mice. Serotonin 169-188 RB transcriptional corepressor 1 Mus musculus 133-136 21740969-1 2011 We sought to develop a mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) model to characterize the effects of ginsenoside Rb1 (Rb1) and estradiol (E(2)) on neural 5-hydroxytryptamine (5-HT) concentration in ovariectomized mice. Serotonin 190-194 RB transcriptional corepressor 1 Mus musculus 133-136 21340718-11 2011 Enterochromaffin cells and serotonin in colon were related to the elevated c-fos in CNS (P < 0.05). Serotonin 27-36 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 75-80 21527662-12 2011 Downregulation of MAPK1 may be related to the significant upregulation of HTR2A and downregulation of DRD1, suggesting an interaction in the medial thalamus serotonin-dopamine pathway elicited by airway obstruction. Serotonin 157-166 dopamine receptor D1 Rattus norvegicus 102-106 21543617-1 2011 Accumulating evidence suggests that the transcriptional activator cAMP response element-binding protein 1 (CREB1) is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia. Serotonin 131-140 cAMP responsive element binding protein 1 Homo sapiens 66-105 21543617-1 2011 Accumulating evidence suggests that the transcriptional activator cAMP response element-binding protein 1 (CREB1) is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia. Serotonin 131-140 cAMP responsive element binding protein 1 Homo sapiens 107-112 21441301-0 2011 Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia. Serotonin 0-9 activating transcription factor 2 Homo sapiens 54-59 21886586-2 2011 We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in a Japanese population. Serotonin 129-138 tryptophan hydroxylase 2 Homo sapiens 64-88 21886586-2 2011 We analyzed the association between the variations in the brain tryptophan hydroxylase 2 (TPH2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (METH) dependence/psychosis in a Japanese population. Serotonin 129-138 tryptophan hydroxylase 2 Homo sapiens 90-94 20724079-0 2011 Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Ralpha receptor. Serotonin 23-32 interleukin 15 Mus musculus 0-14 20724079-9 2011 Thus, the effect of IL15 on serotonin transmission may underlie the depressive-like behavior of IL15Ralpha knockout mice. Serotonin 28-37 interleukin 15 Mus musculus 20-24 22076148-6 2011 In vivo, chronic treatment with the non-selective antidepressant imipramine as well as the norepinephrine-selective reuptake inhibitor desipramine or the serotonin-selective reuptake inhibitor fluoxetine all decrease p21 expression, and this was associated with increased neurogenesis. Serotonin 154-163 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 217-220 22046257-7 2011 Spinal L4-L5 immunohistochemistry demonstrated a unique increase in serotonin fibre innervation up to 4.2 +- 1.1 and 2.3 +- 0.3 fold within the dorsal and ventral horn respectively with Alb-OA treatment when compared to uninjured tissue, in addition to a reduction in NR1 NMDA receptor phosphorylation and microglia reactivity. Serotonin 68-77 albumin Rattus norvegicus 186-189 20852044-7 2010 In addition, the contractile responses to serotonin and endothelin-1 were attenuated in Bbs2(-/-) but not Bbs6(-/-) mice. Serotonin 42-51 Bardet-Biedl syndrome 2 (human) Mus musculus 88-92 21087442-8 2010 To evaluate the role of monoamine transporters in the psychostimulant-induced expression of FosB/DeltaFosB, we tested the antidepressant drugs reboxetine, nortriptyline, fluoxetine and venlafaxine (which target the noradrenaline and/or the 5-hydroxytryptamine transporters), the 5-hydroxytryptamine releasing agent dexfenfluramine, and the dopamine transporter inhibitor GBR12909. Serotonin 241-259 FosB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 92-96 20937572-2 2010 In the present study, binding of known ligands (5-Hydroxytryptamine, dopamine and naloxone) to the Celuca pugilator RXR was modeled computationally using the human RXR-alpha as a homology template. Serotonin 48-67 retinoid X receptor alpha Homo sapiens 164-173 20974893-5 2010 Here, we present mass spectral data for authentic N-hydroxytryptamine, 5-hydroxytryptamine (serotonin), and tryptamine to demonstrate that at least some of the published mass spectral data for the YUC in vitro product are not consistent with N-hydroxytryptamine. Serotonin 71-90 flavin monooxygenase Zea mays 197-200 20974893-5 2010 Here, we present mass spectral data for authentic N-hydroxytryptamine, 5-hydroxytryptamine (serotonin), and tryptamine to demonstrate that at least some of the published mass spectral data for the YUC in vitro product are not consistent with N-hydroxytryptamine. Serotonin 92-101 flavin monooxygenase Zea mays 197-200 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase B Homo sapiens 125-144 20679667-5 2010 Affected males in this family showed an inherited hemizygous deletion restricted to NDP and two immediately telomeric genes, monoamine oxidase-B (MAO-B) and monoamine oxidase-A (MAO-A), which encode closely related enzymes that metabolize biogenic amines including serotonin, dopamine, and norepinephrine. Serotonin 265-274 monoamine oxidase B Homo sapiens 146-151 20828630-10 2010 The metabolite of serotonin, 5-hydroxyindole acetic acid (5-HIAA), was increased in the PFC and CA3, by approximately 20%. Serotonin 18-27 carbonic anhydrase 3 Rattus norvegicus 96-99 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 48-57 calcium/calmodulin-dependent protein kinase IV Mus musculus 267-271 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 48-57 calcium/calmodulin-dependent protein kinase kinase 2, beta Mus musculus 311-320 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 48-57 calcium/calmodulin-dependent protein kinase IV Mus musculus 325-331 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 231-240 calcium/calmodulin-dependent protein kinase IV Mus musculus 267-271 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 231-240 calcium/calmodulin-dependent protein kinase kinase 2, beta Mus musculus 311-320 20952540-5 2010 We show here--through gene expression analysis, serotonin treatment of wild-type and Htr2c(-/-) hypothalamic explants, and cell-specific gene deletion in the mouse--that, following its binding to the Htr2c receptor on VMH neurons, serotonin uses a calmodulin kinase (CaMK)-dependent signaling cascade involving CaMKKbeta and CaMKIV to decrease the sympathetic tone and increase bone mass accrual. Serotonin 231-240 calcium/calmodulin-dependent protein kinase IV Mus musculus 325-331 20952540-6 2010 We further show that the transcriptional mediator of these events is CREB, whose phosphorylation on Ser 133 is increased by CaMKIV following serotonin treatment of hypothalamic explants. Serotonin 141-150 calcium/calmodulin-dependent protein kinase IV Mus musculus 124-130 20485326-1 2010 Monoamine oxidases (MAO-A and MAO-B) have a key role in the degradation of amine neurotransmitters, such as dopamine, norepinephrine and serotonin. Serotonin 137-146 monoamine oxidase B Homo sapiens 30-35 20662941-3 2010 We found that BDNF levels in autistic children (n = 146) were significantly higher (t = 6.82; P < 0.0001) than in control children (n = 50) and were positively correlated with platelet serotonin distribution (r = 0.22; P = 0.004). Serotonin 188-197 brain derived neurotrophic factor Homo sapiens 14-18 22127900-5 2010 We investigated the tryptophan hydroxylase gene (TPH2), the rate-limiting enzyme in the production of brain serotonin, by analyzing three different TPH2 gene polymorphisms, transcript expression, and correlation with PWS genetic subtype. Serotonin 108-117 tryptophan hydroxylase 2 Homo sapiens 49-53 19401681-12 2010 Conversion of serotonin to N-acetylserotonin by serotonin N-acetyltransferase may be upregulated in FENNS patients, possibly related to the observed alteration in Trp-5HIAA correlation. Serotonin 14-23 aralkylamine N-acetyltransferase Homo sapiens 48-77 20346991-9 2010 The following agents raised the concentration of microdialysate gastrin (peak response): gastrin-releasing peptide (GRP) (11-fold increase at a near-maximal dose), carbachol (5-fold increase), serotonin (2-fold increase) and isoprenaline (20-fold increase). Serotonin 193-202 gastrin Rattus norvegicus 64-71 19125159-3 2010 This led us to investigate whether variants in the gene coding for tryptophan hydroxylase 2 (TPH2), the brain-specific and rate-limiting enzyme for serotonin biosynthesis, might be predictive for an increased liability for the development of MetS in depressed patients. Serotonin 148-157 tryptophan hydroxylase 2 Homo sapiens 67-91 19125159-3 2010 This led us to investigate whether variants in the gene coding for tryptophan hydroxylase 2 (TPH2), the brain-specific and rate-limiting enzyme for serotonin biosynthesis, might be predictive for an increased liability for the development of MetS in depressed patients. Serotonin 148-157 tryptophan hydroxylase 2 Homo sapiens 93-97 20332520-6 2010 RESULTS: Pre-exposure of DRG neurons projecting from the colon, to histamine or serotonin, increased Ca(2+) responses induced by 4alphaPDD by a protein kinase C (PKC), phospholipase Cbeta (PLCbeta), mitogen-activated protein kinase kinase (MAPKK) and phospholipase A(2) (PLA(2))-dependent mechanisms. Serotonin 80-89 phospholipase A2, group IB, pancreas Mus musculus 251-269 20332520-6 2010 RESULTS: Pre-exposure of DRG neurons projecting from the colon, to histamine or serotonin, increased Ca(2+) responses induced by 4alphaPDD by a protein kinase C (PKC), phospholipase Cbeta (PLCbeta), mitogen-activated protein kinase kinase (MAPKK) and phospholipase A(2) (PLA(2))-dependent mechanisms. Serotonin 80-89 phospholipase A2, group IB, pancreas Mus musculus 271-277 25944668-6 2015 In sgk1(-/-) platelets serotonin content was significantly reduced and activation-dependent secretion of ATP, serotonin and CD63 significantly impaired. Serotonin 23-32 serum/glucocorticoid regulated kinase 1 Homo sapiens 3-12 25944668-6 2015 In sgk1(-/-) platelets serotonin content was significantly reduced and activation-dependent secretion of ATP, serotonin and CD63 significantly impaired. Serotonin 110-119 serum/glucocorticoid regulated kinase 1 Homo sapiens 3-12 25944668-10 2015 Sgk1(-/-) megakaryocytes show significantly reduced expression of Rab27b and serotonin/CD63 levels compared with sgk1(+/+) megakaryocytes. Serotonin 77-86 serum/glucocorticoid regulated kinase 1 Homo sapiens 0-4 25770211-0 2015 Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers. Serotonin 29-38 5-hydroxytryptamine receptor 2C Homo sapiens 63-69 25088178-6 2015 In addition to OT, serotonin receives some attention as one of the main mechanisms controlling the effects of OT. Serotonin 19-28 oxytocin/neurophysin I prepropeptide Homo sapiens 110-112 25154631-11 2015 Using a conditional logistic regression analysis, seizures (p = 0.04) and serotonin syndrome (p = 0.01 based on Sternbach"s criteria and p = 0.004 based on Hunter"s serotonin toxicity criteria) more frequently occurred in SRI-exposed patients. Serotonin 74-83 sorcin Homo sapiens 222-225 25637699-7 2015 Dopamine and serotonin incubated with MAO-A both strongly oligomerized alpha-synuclein (more than 10 times control); pargyline blocked the oligomerization. Serotonin 13-22 synuclein alpha Rattus norvegicus 71-86 25650137-2 2015 The nonsynonymous single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene (rs6265/Val66Met) modulates the central nervous system activity of neurotransmitters involved in reward processing such as serotonin, dopamine, and glutamate. Serotonin 225-234 brain derived neurotrophic factor Homo sapiens 56-89 25650137-2 2015 The nonsynonymous single nucleotide polymorphism in the brain-derived neurotrophic factor (BDNF) gene (rs6265/Val66Met) modulates the central nervous system activity of neurotransmitters involved in reward processing such as serotonin, dopamine, and glutamate. Serotonin 225-234 brain derived neurotrophic factor Homo sapiens 91-95 25528336-2 2015 Concomitant insertion of a hydroxymethyl in the beta-acetamide position and aliphatic groups in C-3 position produced a positive effect on both melatonin (MT1, MT2) and serotonin (5-HT2C) binding affinities. Serotonin 169-178 complement C3 Homo sapiens 96-99 25528336-2 2015 Concomitant insertion of a hydroxymethyl in the beta-acetamide position and aliphatic groups in C-3 position produced a positive effect on both melatonin (MT1, MT2) and serotonin (5-HT2C) binding affinities. Serotonin 169-178 5-hydroxytryptamine receptor 2C Homo sapiens 180-186 25152196-3 2015 Tryptophan hydroxylase isoform-2 (TPH2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for BDP. Serotonin 73-82 tryptophan hydroxylase 2 Homo sapiens 0-32 25152196-3 2015 Tryptophan hydroxylase isoform-2 (TPH2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for BDP. Serotonin 73-82 tryptophan hydroxylase 2 Homo sapiens 34-38 25308507-11 2014 We also observed changes in regulation of the serotonin pathway (Sert, Tph1, Tph2, Htr2a, Lrp5) after treatment with citalopram. Serotonin 46-55 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 83-88 25463650-11 2014 We show that both serotonin content and 5HT2a receptors are increased in the frontal cortex of Ts65Dn mice and that pharmacological blockage of 5HT2a receptors in Ts65Dn mice rescues their context dependent nest building impairment. Serotonin 18-27 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 144-149 25091390-2 2014 Agomelatine is a novel antidepressant drug with melatonin receptor agonistic and serotonin 5-HT2C antagonistic properties. Serotonin 81-90 5-hydroxytryptamine receptor 2C Homo sapiens 91-97 25220896-2 2014 The goal of this work was to directly observe in vivo effects of chronic ethanol self-administration on serotonin 5-HT1A receptor binding with [(18)F]mefway PET neuroimaging in rhesus monkeys. Serotonin 104-113 5-hydroxytryptamine receptor 1A Macaca mulatta 114-120 25220896-12 2014 CONCLUSIONS: The increase in 5-HT1A binding levels during chronic ethanol self-administration demonstrates an important modulation of the serotonin system due to chronic alcohol exposure. Serotonin 138-147 5-hydroxytryptamine receptor 1A Macaca mulatta 29-35 25220896-13 2014 Furthermore, the correlation between 5-HT1A binding in the raphe nuclei and daily ethanol self-administration indicates a relationship between the serotonin system and alcohol self-administration. Serotonin 147-156 5-hydroxytryptamine receptor 1A Macaca mulatta 37-43 24700614-8 2014 Downstream of serotonin, systemic protection was spread through up-regulation of circulating Vegf. Serotonin 14-23 vascular endothelial growth factor A Mus musculus 93-97 25224451-7 2014 Serotonin and noradrenaline reuptake inhibitors, used to treat both depression and SUI, result in enhanced BDNF levels. Serotonin 0-9 brain derived neurotrophic factor Homo sapiens 107-111 25016211-9 2014 To evaluate the involvement of HK-1 and SP in pruritic processing, the effect of [Leu(11)]-HK-1 and [Leu(11)]-SP on the induction of scratching behavior and c-Fos expression by serotonin (5-HT) and histamine was evaluated. Serotonin 177-186 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 157-162 25190618-5 2014 METHODS AND ANALYSIS: To evaluate the role of the 5-HTR2C gene in suicidal behaviour, we will perform a systematic review and a meta-analysis of worldwide reports that have investigated the association between the serotonin system and suicidal behaviour. Serotonin 214-223 5-hydroxytryptamine receptor 2C Homo sapiens 50-57 25017242-0 2014 Peripheral injected cholecystokinin-8S modulates the concentration of serotonin in nerve fibers of the rat brainstem. Serotonin 70-79 cholecystokinin Rattus norvegicus 20-35 25017242-2 2014 It is known that peripheral injection of CCK increases c-Fos-immunoreactivity (Fos-IR) in the nucleus of the solitary tract (NTS) in rats, and injection of the serotonin antagonist ondansetron decreases the number of c-Fos-IR cells in the NTS. Serotonin 160-169 cholecystokinin Rattus norvegicus 41-44 25017242-3 2014 This supports the idea of serotonin contributing to the effects of CCK. Serotonin 26-35 cholecystokinin Rattus norvegicus 67-70 25017242-4 2014 The aim of the present study was to elucidate whether peripherally injected CCK-8S modulates the concentration of serotonin in brain feeding-regulatory nuclei. Serotonin 114-123 cholecystokinin Rattus norvegicus 76-79 25017242-9 2014 In the NTS and DMV we observed a decrease of serotonin-immunoreactivity 90 min after injection of CCK-8S (46+-2 and 49+-8 pixel/section, respectively) compared to vehicle (81+-8 pixel/section, P<0.05). Serotonin 45-54 cholecystokinin Rattus norvegicus 98-101 25017242-11 2014 Our results suggest that serotonin is involved in the mediation of CCK-8"s effects in the brainstem. Serotonin 25-34 cholecystokinin Rattus norvegicus 67-70 24844139-1 2014 Tryptophan hydroxylase 1 (Tph-1), the principal enzyme for peripheral serotonin biosynthesis, provides a novel target to design anabolic agents for osteoporosis. Serotonin 70-79 tryptophan hydroxylase 1 Rattus norvegicus 0-24 24844139-1 2014 Tryptophan hydroxylase 1 (Tph-1), the principal enzyme for peripheral serotonin biosynthesis, provides a novel target to design anabolic agents for osteoporosis. Serotonin 70-79 tryptophan hydroxylase 1 Rattus norvegicus 26-31 24912179-0 2014 Switching brain serotonin with oxytocin. Serotonin 16-25 oxytocin/neurophysin I prepropeptide Homo sapiens 31-39 25019073-4 2014 For example, while gastrin, somatostatin and serotonin inhibit bile duct hyperplasia of cholestatic rats by downregulation of cAMP signaling, secretin has been shown to stimulate the proliferation of normal mice by activation of cyclic adenosine 3",5"-monophosphate (cAMP)-dependent signaling. Serotonin 45-54 secretin Rattus norvegicus 142-150 25244785-1 2014 OBJECTIVE: The changes of pain threshold and expression of 5-hydroxytryptamine(5-HT) and c-Fos in spinal dorsal horn of rats were observed after targetedly damaged the cerebraspinal fluid-contacting nucleus (CSF-contacting nucleus) to provide experimental evidence for the mechanism of regulating pain CSF-contacting nucleus involved in. Serotonin 59-78 colony stimulating factor 2 Rattus norvegicus 208-211 24744682-5 2014 The interaction among cytokines, glucocorticoid, and neurotrophin results in the decrease of hippocampal neurogenesis which has been proved to be important for mood control and pharmaceutical effect of selective serotonin reuptake inhibitors and might be another promising pathway to understand the pathogenesis of PSD. Serotonin 212-221 brain derived neurotrophic factor Homo sapiens 53-65 23172723-2 2014 TPH is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms, TPH1 and TPH2. Serotonin 55-64 tryptophan hydroxylase 2 Homo sapiens 96-100 24144647-8 2014 Chronic hypoxia caused significant increase in serotonin-induced vasoconstriction; the augmented vasoreactivity was attenuated in Trpc1(-/-) and eliminated in Trpc6(-/-) PAs. Serotonin 47-56 transient receptor potential cation channel, subfamily C, member 6 Mus musculus 159-164 25147442-7 2014 In contrast, IL-10 did not alter these parameters but was able to reduce the prooxidant effects yielded by serotonin, adenosine, melatonin, or TNFalpha, in part by restoring the antioxidant enzymes activities. Serotonin 107-116 interleukin 10 Homo sapiens 13-18 24269538-8 2014 Chemerin administration (8 and 16mug/kg) decreased both food intake and body weight compared to vehicle, possibly associated with a significant increase in serotonin synthesis and release, in the hypothalamus. Serotonin 156-165 retinoic acid receptor responder 2 Rattus norvegicus 0-8 24292660-6 2013 This review provides an overview of 5-HT receptor pharmacology and discusses two recent 5-HT receptor subtype-selective drugs, lorcaserin and pimavanserin, which target the 5HT2C and 5HT2A receptors and provide new treatments for obesity and Parkinson"s disease psychosis, respectively. Serotonin 88-92 5-hydroxytryptamine receptor 2C Homo sapiens 173-178 24006087-6 2013 The results of this study showed that the hypophagic effect of serotonin was significantly attenuated by pretreatment with MK- 801 and CNQX (p < 0.05) but AIDA, LY341495 and UBP1112 had no effect (p > 0.05). Serotonin 63-72 axin interactor, dorsalization associated Gallus gallus 158-162 23841447-8 2013 sGCalpha1(-/-) mice exposed to CS exhibited bronchial hyperresponsiveness to serotonin. Serotonin 77-86 guanylate cyclase 1, soluble, alpha 1 Mus musculus 0-9 24041919-1 2013 The recent US Food and Drug Administration (FDA) approval of the serotonin (5-hydroxytryptamine, 5-HT) 5-HT2C receptor agonist lorcaserin for the treatment of obesity represents a new therapeutic drug class available to the clinic. Serotonin 65-74 5-hydroxytryptamine receptor 2C Homo sapiens 103-109 24041919-1 2013 The recent US Food and Drug Administration (FDA) approval of the serotonin (5-hydroxytryptamine, 5-HT) 5-HT2C receptor agonist lorcaserin for the treatment of obesity represents a new therapeutic drug class available to the clinic. Serotonin 76-95 5-hydroxytryptamine receptor 2C Homo sapiens 103-109 23722916-4 2013 Hapten-challenged skin of TRPA1-deficient mice contained diminished levels of inflammatory cytokines, nerve growth factor, and endogenous pruritogens, such as substance P (SP) and serotonin. Serotonin 180-189 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 26-31 23995203-5 2013 Studies investigating suicide, alcohol-related suicide and the rate limiting enzyme of serotonin synthesis, tryptophan hydroxylase 2 (TPH2), remain to date rather limited. Serotonin 87-96 tryptophan hydroxylase 2 Homo sapiens 108-132 23995203-5 2013 Studies investigating suicide, alcohol-related suicide and the rate limiting enzyme of serotonin synthesis, tryptophan hydroxylase 2 (TPH2), remain to date rather limited. Serotonin 87-96 tryptophan hydroxylase 2 Homo sapiens 134-138 23754283-6 2013 In this study, we present evidence that th2 co-localizes with serotonin in the ventral diencephalon and caudal hypothalamus in zebrafish embryos. Serotonin 62-71 tyrosine hydroxylase 2 Danio rerio 40-43 23754283-7 2013 In addition, knockdown of th2 reduces the level of serotonin in the corresponding th2-positive neurons. Serotonin 51-60 tyrosine hydroxylase 2 Danio rerio 26-29 23754283-7 2013 In addition, knockdown of th2 reduces the level of serotonin in the corresponding th2-positive neurons. Serotonin 51-60 tyrosine hydroxylase 2 Danio rerio 82-85 22884959-5 2013 In the present investigation, we demonstrated that acute or repeated infusion of IFN-alpha into the lateral ventricles provoked depressive-like behavior and concomitant changes in serotonin (5-HT) and mRNA expression of particular 5-HT receptors and pro-inflammatory cytokines. Serotonin 180-189 interferon alpha Mus musculus 81-90 23759926-8 2013 These results indicate a possible link between a CML-induced calcium-mediated serotonin release and RAGE. Serotonin 78-87 advanced glycosylation end-product specific receptor Homo sapiens 100-104 23658167-6 2013 Lack of brain serotonin further results in alterations at the stage of Sox2-positive precursor cells, suggesting physiological adaptations to changes in serotonin supply to maintain homeostasis in the neurogenic niche. Serotonin 14-23 SRY (sex determining region Y)-box 2 Mus musculus 71-75 23514379-3 2013 The cause of serotonin deficiency in depression was attributed to the shunt of TRP "metabolism away from serotonin production towards KYN production" due to cortisol-induced activation of liver enzyme, tryptophan 2,3- dioxygenase, the rate-limiting enzyme of TRP - KYN pathway. Serotonin 13-22 tryptophan 2,3-dioxygenase Homo sapiens 202-229 23593198-2 2013 Serotonin levels and turnover are also increased by brain-derived neurotrophic factor (BDNF). Serotonin 0-9 brain derived neurotrophic factor Homo sapiens 52-85 23593198-2 2013 Serotonin levels and turnover are also increased by brain-derived neurotrophic factor (BDNF). Serotonin 0-9 brain derived neurotrophic factor Homo sapiens 87-91 23149761-2 2013 The TRA (3-[2-aminoethyl]indole) is an important neurotransmitter with a close structural and chemical similarity to the neurotransmitter serotonin (5-hydroxytryptamine), and to melatonin (5-methoxy-N-acetyltryptamine), which plays a key role in daily human behavior. Serotonin 138-147 T cell receptor alpha locus Homo sapiens 4-7 23149761-2 2013 The TRA (3-[2-aminoethyl]indole) is an important neurotransmitter with a close structural and chemical similarity to the neurotransmitter serotonin (5-hydroxytryptamine), and to melatonin (5-methoxy-N-acetyltryptamine), which plays a key role in daily human behavior. Serotonin 149-168 T cell receptor alpha locus Homo sapiens 4-7 23159831-0 2013 Serotonin hyperinnervation and upregulated 5-HT2A receptor expression and motor-stimulating function in nigrostriatal dopamine-deficient Pitx3 mutant mice. Serotonin 0-9 paired-like homeodomain transcription factor 3 Mus musculus 137-142 22954717-1 2013 Central injections of serotonin (5-HT) produce hyperdipsic and hypnogenic behavioral effects that are correlated to decreased Fos-immunorreactivity of 5-HT neurons in free-feeding pigeons. Serotonin 22-31 LOW QUALITY PROTEIN: proto-oncogene c-Fos Columba livia 126-129 23505381-1 2013 In Caenorhabditis elegans the Toll-interleukin receptor domain adaptor protein TIR-1 via a conserved mitogen-activated protein kinase (MAPK) signaling cascade induces innate immunity and upregulates serotonin (5-HT) biosynthesis gene tph-1 in a pair of ADF chemosensory neurons in response to infection. Serotonin 199-208 Mitogen-activated protein kinase 15 Caenorhabditis elegans 101-133 23505381-1 2013 In Caenorhabditis elegans the Toll-interleukin receptor domain adaptor protein TIR-1 via a conserved mitogen-activated protein kinase (MAPK) signaling cascade induces innate immunity and upregulates serotonin (5-HT) biosynthesis gene tph-1 in a pair of ADF chemosensory neurons in response to infection. Serotonin 199-208 Mitogen-activated protein kinase 15 Caenorhabditis elegans 135-139 23428688-9 2013 Sibutramine, serotonin and noradrenalin reuptake inhibitor, in MC4R mutation carriers induced weight reduction and improved cardiometabolic health risks. Serotonin 13-22 melanocortin 4 receptor Homo sapiens 63-67 23223282-7 2012 Together, these results support the hypothesis that stress-induced activation of the dynorphin/KOR system produces a transient increase in serotonin transport locally in the ventral striatum that may underlie some of the adverse consequences of stress exposure, including the potentiation of the rewarding effects of cocaine. Serotonin 139-148 opioid receptor, kappa 1 Mus musculus 95-98 22948388-2 2012 Recently, attention has been focused on nerve-growth factor (NGF), a neurotrophin that is a key regulator of peripheral nociception because it mediates overexpression of proinflammatory neuron-derived molecules such as substance P, serotonin, and calcitonin gene-related peptide. Serotonin 232-241 brain derived neurotrophic factor Homo sapiens 69-81 22923644-8 2012 Inhibition of serotonin synthesis pharmacologically or by small interfering RNAs to Tph1 in PAECs inhibited the PAEC-induced activation of TGF-beta signaling and differentiation of PASMCs. Serotonin 14-23 tryptophan hydroxylase 1 Rattus norvegicus 84-88 23087410-9 2012 Serotonin antagonists of receptors 1B and 2B consistently decreased viability and proliferation in Huh7 and HepG2 cell lines. Serotonin 0-9 MIR7-3 host gene Homo sapiens 99-103 25205989-12 2012 Since TPH and MAO levels regulate circulating and physiologically available serotonin content, the regulation of serotonin metabolizing enzymes suggest a plausible mechanism by which estrogen alleviates migraine in women. Serotonin 76-85 tryptophan hydroxylase 1 Rattus norvegicus 6-9 22704666-2 2012 CRFR2 in the midbrain raphe nuclei modulate serotonergic activity of this key source of serotonin (5-HT) forebrain innervation. Serotonin 88-97 corticotropin releasing hormone receptor 2 Mus musculus 0-5 22954188-4 2012 Here we report a novel MPO-sensing probe obtained by replacing the reducing substrate serotonin (5-HT) with 5-hydroxytryptophan (HTrp). Serotonin 86-95 myeloperoxidase Mus musculus 23-26 22659115-1 2012 Serotonin (5-HT) can constrict cerebral arteries via activation of 5-HT(1B) and 5-HT(2A) receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 67-74 22733632-4 2012 Research shows that not all infants and children are equally affected; thus appreciating the effects of prenatal and postnatal maternal mental illness and of genetic variations that influence early serotonin signaling offers critical new insights into factors that contribute to developmental risk, plasticity, and resiliency in children with prenatal SRI exposure. Serotonin 198-207 sorcin Homo sapiens 352-355 22738345-6 2012 RESULTS: MALDI-TOF spectrum showed that the 5HT base agent can self oligomerize after activating by MPO. Serotonin 44-47 myeloperoxidase Mus musculus 100-103 22721594-4 2012 Reciprocal relationships have been described between brain oxytocin and serotonin systems during development. Serotonin 72-81 oxytocin/neurophysin I prepropeptide Homo sapiens 59-67 22158544-6 2012 A recently discovered isoform, TPH2, is responsible for serotonin biosynthesis in the brain. Serotonin 56-65 tryptophan hydroxylase 2 Homo sapiens 31-35 22557981-1 2012 The integrinbeta3 (ITGbeta3) gene has been associated with both autism and the serotonin system. Serotonin 79-88 integrin beta 3 Mus musculus 4-27 22511363-1 2012 BACKGROUND: Allelic variations in TPH2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-HT) biosynthesis, may be genetic predictors of panic disorder and panic responses to panicogenic challenges in healthy volunteers. Serotonin 119-128 tryptophan hydroxylase 2 Rattus norvegicus 34-38 22511363-1 2012 BACKGROUND: Allelic variations in TPH2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-HT) biosynthesis, may be genetic predictors of panic disorder and panic responses to panicogenic challenges in healthy volunteers. Serotonin 119-128 tryptophan hydroxylase 2 Rattus norvegicus 58-82 21947356-9 2012 In contrast, both therapeutic and supratherapeutic concentrations of CBZ inhibited CRF2-induced serotonin release without affecting CRF1-induced serotonin reduction. Serotonin 96-105 corticotropin releasing hormone receptor 2 Rattus norvegicus 83-87 21818550-11 2012 Our findings suggest that serotonin acts on brain IPCs via the 5-HT(1A) receptor, thereby affecting their activity and probably insulin signaling. Serotonin 26-35 5-hydroxytryptamine (serotonin) receptor 1A Drosophila melanogaster 63-70 21818550-11 2012 Our findings suggest that serotonin acts on brain IPCs via the 5-HT(1A) receptor, thereby affecting their activity and probably insulin signaling. Serotonin 26-35 Insulin-like receptor Drosophila melanogaster 128-135 22123816-6 2012 Taken together, our results indicate that Ahi1 mediates feeding behavior by interacting with 5-HT(2C)R to modulate the serotonin signaling pathway. Serotonin 119-128 5-hydroxytryptamine receptor 2C Homo sapiens 93-100 22177902-0 2012 Serotonin signaling is required for Wnt-dependent GRP specification and leftward flow in Xenopus. Serotonin 0-9 upper zone of growth plate and cartilage matrix associated S homeolog Xenopus laevis 50-53 22177902-6 2012 Here, we report that serotonin signaling is required for specification of the superficial mesoderm (SM), which gives rise to the ciliated gastrocoel roof plate (GRP) where flow occurs [5, 9]. Serotonin 21-30 upper zone of growth plate and cartilage matrix associated S homeolog Xenopus laevis 161-164 22177902-8 2012 Serotonin, which we found uniformly distributed along the main body axes in the early embryo, was required for Wnt signaling, which provides the instructive signal to specify the GRP. Serotonin 0-9 upper zone of growth plate and cartilage matrix associated S homeolog Xenopus laevis 179-182 23346101-0 2012 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. Serotonin 44-53 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 0-6 23346101-0 2012 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. Serotonin 44-53 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 12-18 23346101-1 2012 Although 5HT(2A) receptors mediate contractions of normal arteries to serotonin (5HT), in some cardiovascular diseases, other receptor subtypes contribute to the marked increase in serotonin contractions. Serotonin 70-79 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 9-15 24244046-0 2012 Human Serotonin 5-HT2C G Protein-Coupled Receptor Homology Model from the beta2 Adrenoceptor Structure: Ligand Docking and Mutagenesis Studies. Serotonin 6-15 5-hydroxytryptamine receptor 2C Homo sapiens 16-22 23094101-2 2012 A genetically identified population of ventromedial interneurons, called Hb9, in the mouse spinal cord has been shown to generate TTX-resistant membrane potential oscillations in the presence of NMDA, serotonin and dopamine, but these oscillatory properties are not well characterized. Serotonin 201-210 motor neuron and pancreas homeobox 1 Mus musculus 73-76 22900031-7 2012 Inhalation of the small molecule synthetic Pak1 inhibitor, IPA3, also significantly reduced in vivo airway responsiveness to ACh and 5-hydroxytryptamine (5-Ht) in wild type mice. Serotonin 133-152 p21 (RAC1) activated kinase 1 Mus musculus 43-47 22253933-0 2012 Induction of VMAT-1 and TPH-1 expression induces vesicular accumulation of serotonin and protects cells and tissue from cooling/rewarming injury. Serotonin 75-84 tryptophan hydroxylase 1 Rattus norvegicus 24-29 22253933-10 2012 Thus, transfection of VMAT-1 and TPH-1 induced vesicular storage of serotonin which is triggered release upon cooling and has protective effects against hypothermia. Serotonin 68-77 tryptophan hydroxylase 1 Rattus norvegicus 33-38 21930121-11 2011 The inhibitory action by the selective serotonin re-uptake inhibitor (SSRI) paroxetine on hippocampal BDNF mRNA was also attenuated by CGP 46381. Serotonin 39-48 brain-derived neurotrophic factor Rattus norvegicus 102-106 21732322-0 2011 Interactions of beta-lactoglobulin with serotonin and arachidonyl serotonin. Serotonin 40-49 beta-lactoglobulin Bos taurus 16-34 21732322-6 2011 In this study, the interaction of serotonin and one of its derivatives, arachidonyl serotonin (AA-5HT), with beta-LG was investigated using circular dichroism (CD) and fluorescence intensity measurements. Serotonin 34-43 beta-lactoglobulin Bos taurus 109-116 21732322-8 2011 The binding constant for the serotonin/beta-LG interaction is between 105 and 106 M(-1) , whereas for the AA-5HT/beta-LG complex it is between 104 and 105 M(-1) as determined by measurements of either protein or ligand fluorescence. Serotonin 29-38 beta-lactoglobulin Bos taurus 39-46 21732322-10 2011 The interactions between serotonin/beta-LG and AA-5HT/beta-LG may compete with self-association (micellization) of both the ligand and the protein. Serotonin 25-34 beta-lactoglobulin Bos taurus 35-42 21732322-10 2011 The interactions between serotonin/beta-LG and AA-5HT/beta-LG may compete with self-association (micellization) of both the ligand and the protein. Serotonin 25-34 beta-lactoglobulin Bos taurus 54-61 21732322-12 2011 Their binding by beta-LG may be one of the peripheral mechanisms of the regulation of the content of serotonin and its derivatives in the bowel of milk-fed animals. Serotonin 101-110 beta-lactoglobulin Bos taurus 17-24 21910766-2 2011 Previously, we reported that STX1A null mutant (STX1A KO) mice unexpectedly showed normal glutamatergic and GABAergic fast synaptic transmission but exhibited disturbances in monoaminergic transmission, such as serotonin, 5-hydroxytryptamine (5-HT), which may induce attenuation of latent inhibition. Serotonin 211-220 syntaxin 1A (brain) Mus musculus 29-34 21910766-2 2011 Previously, we reported that STX1A null mutant (STX1A KO) mice unexpectedly showed normal glutamatergic and GABAergic fast synaptic transmission but exhibited disturbances in monoaminergic transmission, such as serotonin, 5-hydroxytryptamine (5-HT), which may induce attenuation of latent inhibition. Serotonin 211-220 syntaxin 1A (brain) Mus musculus 48-53 21910766-2 2011 Previously, we reported that STX1A null mutant (STX1A KO) mice unexpectedly showed normal glutamatergic and GABAergic fast synaptic transmission but exhibited disturbances in monoaminergic transmission, such as serotonin, 5-hydroxytryptamine (5-HT), which may induce attenuation of latent inhibition. Serotonin 222-241 syntaxin 1A (brain) Mus musculus 29-34 21910766-2 2011 Previously, we reported that STX1A null mutant (STX1A KO) mice unexpectedly showed normal glutamatergic and GABAergic fast synaptic transmission but exhibited disturbances in monoaminergic transmission, such as serotonin, 5-hydroxytryptamine (5-HT), which may induce attenuation of latent inhibition. Serotonin 222-241 syntaxin 1A (brain) Mus musculus 48-53 21910766-2 2011 Previously, we reported that STX1A null mutant (STX1A KO) mice unexpectedly showed normal glutamatergic and GABAergic fast synaptic transmission but exhibited disturbances in monoaminergic transmission, such as serotonin, 5-hydroxytryptamine (5-HT), which may induce attenuation of latent inhibition. Serotonin 243-247 syntaxin 1A (brain) Mus musculus 29-34 21910766-2 2011 Previously, we reported that STX1A null mutant (STX1A KO) mice unexpectedly showed normal glutamatergic and GABAergic fast synaptic transmission but exhibited disturbances in monoaminergic transmission, such as serotonin, 5-hydroxytryptamine (5-HT), which may induce attenuation of latent inhibition. Serotonin 243-247 syntaxin 1A (brain) Mus musculus 48-53 22120177-5 2011 This negative regulatory function requires stimulation of the 5-hydroxytryptamine 2B receptor (5-HT(2B)) on HSCs by serotonin, which activates expression of transforming growth factor beta1 (TGF-beta1), a powerful suppressor of hepatocyte proliferation, through signaling by mitogen-activated protein kinase 1 (ERK) and the transcription factor JunD. Serotonin 116-125 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 95-103 21977017-8 2011 Finally, because serotonin (5-HT) neurons are pivotal to respiratory and thermoregulatory circuits and depend on Phox2b for their differentiation, we studied 5-HT metabolism using high pressure liquid chromatography, and found that it was altered in Phox2b(+/-) pups. Serotonin 17-26 paired-like homeobox 2b Mus musculus 113-119 21977017-8 2011 Finally, because serotonin (5-HT) neurons are pivotal to respiratory and thermoregulatory circuits and depend on Phox2b for their differentiation, we studied 5-HT metabolism using high pressure liquid chromatography, and found that it was altered in Phox2b(+/-) pups. Serotonin 17-26 paired-like homeobox 2b Mus musculus 250-256 22040433-8 2011 RESULTS: Serotonin (10 micromol/L) induced the upregulation of phosphorylation of ERK1/ERK2 and PCNA, an increase in the percentage of cells in S phase and subsequent cell proliferation. Serotonin 9-18 mitogen-activated protein kinase 3 Sus scrofa 82-86 22040433-11 2011 CONCLUSION: This study shows that sildenafil potentiated the proliferative effect of serotonin on PASMCs via phosphorylation of ERK1/ERK2. Serotonin 85-94 mitogen-activated protein kinase 3 Sus scrofa 128-132 21401876-1 2011 Brain-derived neurotrophic factor (BDNF) gene has an important link to neurotransmitter systems, including serotonin, and seems to play a major role in emotional decision making. Serotonin 107-116 brain derived neurotrophic factor Homo sapiens 0-33 21401876-1 2011 Brain-derived neurotrophic factor (BDNF) gene has an important link to neurotransmitter systems, including serotonin, and seems to play a major role in emotional decision making. Serotonin 107-116 brain derived neurotrophic factor Homo sapiens 35-39 21420449-0 2011 CB-1 receptors modulate the effect of the selective serotonin reuptake inhibitor, citalopram on extracellular serotonin levels in the rat prefrontal cortex. Serotonin 52-61 cannabinoid receptor 1 Rattus norvegicus 0-4 21420449-4 2011 Stimulating CB-1 decreased the effect of citalopram on increasing serotonin levels in the prefrontal cortex. Serotonin 66-75 cannabinoid receptor 1 Rattus norvegicus 12-16 21494145-7 2011 Further, serotonin metabolites act as endogenous agonists for peroxisome proliferator-activated receptor gamma and serotonin accelerates adipocyte differentiation via serotonin receptor 2A and 2C. Serotonin 9-18 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 167-195 21494145-7 2011 Further, serotonin metabolites act as endogenous agonists for peroxisome proliferator-activated receptor gamma and serotonin accelerates adipocyte differentiation via serotonin receptor 2A and 2C. Serotonin 115-124 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 167-195 21599922-3 2011 In Xenopus, movement of maternal serotonin (5HT) through gap-junctional paths at cleavage stages dictates asymmetry upstream of Nr1. Serotonin 33-42 nodal homolog 1 L homeolog Xenopus laevis 128-131 21599922-3 2011 In Xenopus, movement of maternal serotonin (5HT) through gap-junctional paths at cleavage stages dictates asymmetry upstream of Nr1. Serotonin 44-47 nodal homolog 1 L homeolog Xenopus laevis 128-131 21599922-11 2011 While Mad3 overexpression led to an absence of Nr1 transcription and randomized the LR axis, a mutant form of Mad3 lacking 5HT binding sites was not able to induce heterotaxia, showing that Mad3"s biological activity is dependent on 5HT binding. Serotonin 123-126 MAX dimerization protein 3 S homeolog Xenopus laevis 110-114 21599922-11 2011 While Mad3 overexpression led to an absence of Nr1 transcription and randomized the LR axis, a mutant form of Mad3 lacking 5HT binding sites was not able to induce heterotaxia, showing that Mad3"s biological activity is dependent on 5HT binding. Serotonin 123-126 MAX dimerization protein 3 S homeolog Xenopus laevis 110-114 21599922-13 2011 The HDAC binding partner Mad3 may be a new serotonin-dependent regulator of asymmetry linking early physiological asymmetries to stable changes in gene expression during organogenesis. Serotonin 43-52 MAX dimerization protein 3 S homeolog Xenopus laevis 25-29 21518801-2 2011 In this study, we show that serotonin (5-hydroxytryptamine [5-HT]) stored in platelets strongly induces extracellular matrix synthesis in interstitial fibroblasts via activation of 5-HT(2B) receptors (5-HT(2B)) in a transforming growth factor beta (TGF-beta)-dependent manner. Serotonin 28-37 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 181-188 21518801-2 2011 In this study, we show that serotonin (5-hydroxytryptamine [5-HT]) stored in platelets strongly induces extracellular matrix synthesis in interstitial fibroblasts via activation of 5-HT(2B) receptors (5-HT(2B)) in a transforming growth factor beta (TGF-beta)-dependent manner. Serotonin 28-37 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 201-208 21518801-2 2011 In this study, we show that serotonin (5-hydroxytryptamine [5-HT]) stored in platelets strongly induces extracellular matrix synthesis in interstitial fibroblasts via activation of 5-HT(2B) receptors (5-HT(2B)) in a transforming growth factor beta (TGF-beta)-dependent manner. Serotonin 39-58 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 181-188 21518801-2 2011 In this study, we show that serotonin (5-hydroxytryptamine [5-HT]) stored in platelets strongly induces extracellular matrix synthesis in interstitial fibroblasts via activation of 5-HT(2B) receptors (5-HT(2B)) in a transforming growth factor beta (TGF-beta)-dependent manner. Serotonin 39-58 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 201-208 21648199-3 2011 Serotonin-related genes that are found in OCD include those coding for the 5-HT transporter (5-HTT) and receptors (5-HT(2A), 5-HT(2B), 5-HT(2C) and 5-HT(1B)) as well the 5-HT enzyme tryptophan hydroxylase. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 125-132 21266593-2 2011 The development of UGT1A1 and 1A6 was studied in 50 pediatric liver samples using bilirubin, serotonin activity assays, and Western blot as well as pharmacokinetic scaling. Serotonin 93-102 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 19-33 21418060-2 2011 As aberrant serotonergic functioning is strongly implicated in PWS, we examined associations between the PWS phenotype and polymorphisms in tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of serotonin in the brain. Serotonin 221-230 tryptophan hydroxylase 2 Homo sapiens 140-164 21418060-2 2011 As aberrant serotonergic functioning is strongly implicated in PWS, we examined associations between the PWS phenotype and polymorphisms in tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of serotonin in the brain. Serotonin 221-230 tryptophan hydroxylase 2 Homo sapiens 166-170 20869124-1 2011 The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. Serotonin 165-174 tryptophan hydroxylase 2 Homo sapiens 63-87 20869124-1 2011 The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. Serotonin 165-174 tryptophan hydroxylase 2 Homo sapiens 89-93 21303932-11 2011 Serotonin and 17beta-estradiol increased CEBPbeta, CYP1B1, and FOS protein expression in PASMCs. Serotonin 0-9 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 51-57 21262218-0 2011 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected]. Serotonin 0-19 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 103-106 21262218-0 2011 5-Hydroxytryptamine induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation [corrected]. Serotonin 0-19 protein kinase C, gamma Rattus norvegicus 108-111 21272616-2 2011 TPH2 is the genetic isoform of TPH that catalyzes the rate-limiting step in serotonin biosynthesis within the central nervous system. Serotonin 76-85 tryptophan hydroxylase 2 Rattus norvegicus 0-4 21272616-2 2011 TPH2 is the genetic isoform of TPH that catalyzes the rate-limiting step in serotonin biosynthesis within the central nervous system. Serotonin 76-85 tryptophan hydroxylase 1 Rattus norvegicus 0-3 21257271-1 2011 Based on genetic variation, there is accumulating evidence that altered function of tryptophan hydroxylase-2 (TPH2), the enzyme critical for synthesis of serotonin (5-HT) in the brain, plays a role in anxiety-, aggression- and depression-related personality traits and in the pathogenesis of disorders featuring deficits in cognitive control and emotion regulation. Serotonin 154-163 tryptophan hydroxylase 2 Homo sapiens 84-108 21257271-1 2011 Based on genetic variation, there is accumulating evidence that altered function of tryptophan hydroxylase-2 (TPH2), the enzyme critical for synthesis of serotonin (5-HT) in the brain, plays a role in anxiety-, aggression- and depression-related personality traits and in the pathogenesis of disorders featuring deficits in cognitive control and emotion regulation. Serotonin 154-163 tryptophan hydroxylase 2 Homo sapiens 110-114 21143251-9 2011 RESULTS: The top signals included clusters of SNPs in tryptophan hydroxylase 2 (TPH2) (e.g., rs1386496, p = 0.0003) and dopa decarboxylase (DDC) (e.g., rs3779084, p = 0.0008), genes that encode proteins responsible for serotonin synthesis. Serotonin 219-228 tryptophan hydroxylase 2 Homo sapiens 54-78 21143251-9 2011 RESULTS: The top signals included clusters of SNPs in tryptophan hydroxylase 2 (TPH2) (e.g., rs1386496, p = 0.0003) and dopa decarboxylase (DDC) (e.g., rs3779084, p = 0.0008), genes that encode proteins responsible for serotonin synthesis. Serotonin 219-228 tryptophan hydroxylase 2 Homo sapiens 80-84 21143251-13 2011 CONCLUSIONS: While no results survive the burden of multiple testing, nominal findings in TPH2 and DDC suggest the potential role of the serotonin synthesis pathway in alcohol consumption. Serotonin 137-146 tryptophan hydroxylase 2 Homo sapiens 90-94 20938755-3 2011 Tryptophan hydroxylase 2 (TPH2), a newly identified isoform of tryptophan hydroxylase (the rate limiting enzyme in the biosynthesis of serotonin), regulates the brain-specific serotonin synthesis. Serotonin 135-144 tryptophan hydroxylase 2 Homo sapiens 0-24 20938755-3 2011 Tryptophan hydroxylase 2 (TPH2), a newly identified isoform of tryptophan hydroxylase (the rate limiting enzyme in the biosynthesis of serotonin), regulates the brain-specific serotonin synthesis. Serotonin 135-144 tryptophan hydroxylase 2 Homo sapiens 26-30 20938755-3 2011 Tryptophan hydroxylase 2 (TPH2), a newly identified isoform of tryptophan hydroxylase (the rate limiting enzyme in the biosynthesis of serotonin), regulates the brain-specific serotonin synthesis. Serotonin 176-185 tryptophan hydroxylase 2 Homo sapiens 0-24 20938755-3 2011 Tryptophan hydroxylase 2 (TPH2), a newly identified isoform of tryptophan hydroxylase (the rate limiting enzyme in the biosynthesis of serotonin), regulates the brain-specific serotonin synthesis. Serotonin 176-185 tryptophan hydroxylase 2 Homo sapiens 26-30 21073637-2 2011 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: TPH1 and TPH2. Serotonin 80-89 tryptophan hydroxylase 2 Homo sapiens 121-125 21252298-10 2011 Mutant analysis further showed that lateral root induction elicited by serotonin was independent of the AUX1 and AXR4 loci but required AXR1 and AXR2. Serotonin 71-80 NAD(P)-binding Rossmann-fold superfamily protein Arabidopsis thaliana 136-140 20843634-1 2011 Serotonin 1B (5-HT(1B)) heteroreceptors on nucleus accumbens shell (NAcSh) projection neurons have been shown to enhance the voluntary consumption of alcohol by rats, presumably by modulating the activity of the mesolimbic reward pathway. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 14-21 21325831-0 2011 Regulation of serotonin transport in human platelets by tyrosine kinase Syk. Serotonin 14-23 spleen associated tyrosine kinase Homo sapiens 72-75 22035029-10 2011 In patients treated with selective MAO-B inhibitors, the risk of serotonin toxicity (ST) due to a concomitant serotonergic agent (e.g., antidepressants, dextromethorphan, serotonergic analgesics) or hypertensive crisis due to dietary tyramine or sympathomimetic amines appears to be minimal and is based on isolated case reports and overgeneralizations from nonselective MAO inhibitor pharmacology. Serotonin 65-74 monoamine oxidase B Homo sapiens 35-40 20837046-4 2010 Recent refined genetic studies now indicate that a primary mechanism through which serotonin influences appetite and body weight is via serotonin 2C receptor (5-HT(2C)R) and serotonin 1B receptor (5-HT(1B)R) influencing the activity of endogenous melanocortin receptor agonists and antagonists at the melanocortin 4 receptor (MC4R). Serotonin 83-92 melanocortin 4 receptor Homo sapiens 301-324 20837046-4 2010 Recent refined genetic studies now indicate that a primary mechanism through which serotonin influences appetite and body weight is via serotonin 2C receptor (5-HT(2C)R) and serotonin 1B receptor (5-HT(1B)R) influencing the activity of endogenous melanocortin receptor agonists and antagonists at the melanocortin 4 receptor (MC4R). Serotonin 83-92 melanocortin 4 receptor Homo sapiens 326-330 20600751-11 2010 CONCLUSIONS: Treatment with TXL, similar to that with fasudil, can effectively prevent collar-induced vasoconstriction and vascular hyperreactivity to serotonin through inhibiting the RhoA/Rho-kinase pathway. Serotonin 151-160 ras homolog family member A Rattus norvegicus 184-188 23051576-4 2010 I present a case report of PLP showing good response to Milnacipran - a novel antidepressant (SNRI) with dual mechanism of action through serotonin and norepinephrine reuptake inhibition similar to TCAs. Serotonin 138-147 proteolipid protein 1 Homo sapiens 27-30 20660061-4 2010 In contrast, genetically engineered mouse models have demonstrated a bimodal control system whereby gut-derived serotonin under the control of the Wnt/Lrp/beta-catenin system acts systemically to suppress bone formation, whereas CNS serotonin activated by leptin modulates sympathetic outflow to the skeleton. Serotonin 112-121 low density lipoprotein receptor-related protein 1 Mus musculus 151-154 20660061-4 2010 In contrast, genetically engineered mouse models have demonstrated a bimodal control system whereby gut-derived serotonin under the control of the Wnt/Lrp/beta-catenin system acts systemically to suppress bone formation, whereas CNS serotonin activated by leptin modulates sympathetic outflow to the skeleton. Serotonin 112-121 catenin (cadherin associated protein), beta 1 Mus musculus 155-167 20332520-10 2010 CONCLUSIONS: Serotonin and histamine sensitise TRPV4 response to 4alphaPDD both in vivo (increased visceral hypersensitivity) and in vitro, in sensory neurons, by a PKC, PLA(2), PLCbeta and MAPKK-dependent mechanism. Serotonin 13-22 phospholipase A2, group IB, pancreas Mus musculus 170-176 19800079-3 2010 Tryptophan hydroxylase 2 (TPH2) which is a rate limiting enzyme in the serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. Serotonin 71-80 tryptophan hydroxylase 2 Homo sapiens 0-24 19800079-3 2010 Tryptophan hydroxylase 2 (TPH2) which is a rate limiting enzyme in the serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. Serotonin 71-80 tryptophan hydroxylase 2 Homo sapiens 26-30 19800635-0 2010 Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c. Serotonin 56-65 integrin subunit alpha M Homo sapiens 100-105 20043001-2 2010 We tested the hypothesis that variations in serotonergic genes (TPH2, TPH1, SLC6A4, HTR1A), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. Serotonin 108-117 tryptophan hydroxylase 2 Homo sapiens 64-68 20407608-3 2010 There was some evidence that serotonin-related genes might interact with the alcohol dehydrogenase (ADH) and the aldehyde dehydrogenase (ALDH) genes in the development of alcohol dependence. Serotonin 29-38 aldo-keto reductase family 1 member A1 Homo sapiens 77-98 20133816-2 2010 We now demonstrate by immunoblotting and immunofluorescence microscopy that platelet MRP4 is absent in two patients with a platelet delta-storage pool deficiency (delta-SPD)-like phenotype with reduced platelet adenine nucleotide (AN) but normal serotonin levels, whereas their other membrane marker proteins of platelet granules were normally expressed and localized. Serotonin 246-255 ATP binding cassette subfamily C member 4 Homo sapiens 85-89 20163460-5 2010 Cells pre-exposed to rosiglitazone showed a dose-dependent reduction in proliferation in response to serotonin; this was abolished by pretransfection of cells with sequence-specific small interfering RNA against HO-1. Serotonin 101-110 heme oxygenase 1 Rattus norvegicus 212-216 19995940-2 2010 Here we examined the effect of in vivo exposure to the selective serotonin uptake inhibitor fluoxetine on cannabinoid type 1 (CB(1)) receptor density and functionality in the rat prefrontal cortex (PFC) and cerebellum. Serotonin 65-74 cannabinoid receptor 1 Rattus norvegicus 126-131 20606323-4 2010 At the same time, L-type amino acid transporter 1 (LAT1) mRNA expression in the brain capillary fraction of the MPTP-treated mice was significantly reduced by 62.6% compared with saline-treated mice, while no significant change was observed in the expression of glucose transporter 1, creatine transporter 1, taurine transporter, organic cation transporter 2, serotonin transporter, norepinephrine transporter and dopamine transporter. Serotonin 360-369 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 Mus musculus 18-49 20606323-4 2010 At the same time, L-type amino acid transporter 1 (LAT1) mRNA expression in the brain capillary fraction of the MPTP-treated mice was significantly reduced by 62.6% compared with saline-treated mice, while no significant change was observed in the expression of glucose transporter 1, creatine transporter 1, taurine transporter, organic cation transporter 2, serotonin transporter, norepinephrine transporter and dopamine transporter. Serotonin 360-369 solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 Mus musculus 51-55 19656124-4 2009 RESULTS: Reducing maternal corticosterone (mCORT) during gestation led to alterations in dopamine and serotonin levels in all three brain areas studied at PN 23. Serotonin 102-111 cortistatin Mus musculus 43-48 19817843-6 2009 These results suggest that serotonin signaling through NAc 5-HT(1B) heteroreceptors can interact with stress to increase susceptibility to the enduring forms of drug-induced plasticity that are associated with addiction. Serotonin 27-36 5-hydroxytryptamine receptor 1B Rattus norvegicus 59-66 19552725-1 2009 Colocalization of the classic neurotransmitters serotonin (5-HT) and gamma-aminobutyric acid (GABA) (or the enzyme that synthesizes the latter, glutamate decarboxylase) has been reported in a few neurons of the rat raphe magnus-obscurus nuclei. Serotonin 48-57 glutamate-ammonia ligase Rattus norvegicus 144-167 19737523-4 2009 We show here that brainstem-derived serotonin (BDS) favors bone mass accrual following its binding to Htr2c receptors on ventromedial hypothalamic neurons and appetite via Htr1a and 2b receptors on arcuate neurons. Serotonin 36-45 5-hydroxytryptamine receptor 2C Homo sapiens 102-107 19360904-0 2009 Histone deacetylase inhibitors promote neurosteroid-mediated cell differentiation and enhance serotonin-stimulated brain-derived neurotrophic factor gene expression in rat C6 glioma cells. Serotonin 94-103 brain-derived neurotrophic factor Rattus norvegicus 115-148 19360904-1 2009 Progesterone treatment has previously been reported to promote the differentiation of glial cells probably through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated brain-derived neurotrophic factor (BDNF) gene expression, which is considered to contribute to the survival, regeneration, and plasticity of neuronal cells in the brain and hence has been suggested to improve mood disorders and other symptoms in depressive patients. Serotonin 195-204 brain derived neurotrophic factor Homo sapiens 216-249 19360904-1 2009 Progesterone treatment has previously been reported to promote the differentiation of glial cells probably through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated brain-derived neurotrophic factor (BDNF) gene expression, which is considered to contribute to the survival, regeneration, and plasticity of neuronal cells in the brain and hence has been suggested to improve mood disorders and other symptoms in depressive patients. Serotonin 195-204 brain derived neurotrophic factor Homo sapiens 251-255 19494238-5 2009 Stimulation of smooth muscle cells with 5-hydroxytryptamine (5-HT) resulted in the decrease in Cdc42GAP activity. Serotonin 40-59 Rho GTPase activating protein 1 Homo sapiens 95-103 19461660-2 2009 Brain-derived neurotrophic factor (BDNF) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of PD. Serotonin 112-121 brain derived neurotrophic factor Homo sapiens 0-33 19461660-2 2009 Brain-derived neurotrophic factor (BDNF) gene, which has regulatory effects on neurotransmitter systems such as serotonin and dopamine, is a candidate for susceptibility locus of PD. Serotonin 112-121 brain derived neurotrophic factor Homo sapiens 35-39 8566934-2 1995 PAF (1 microgram/kg, iv) induced a marked increase in Evans blue dye content in trachea, main bronchi and small bronchi, that was significantly reduced upon pretreatment of the rats with BN 50730 (25 mg/kg, orally) and by the serotonin antagonist, methysergide (1 mg/kg, iv), only in the small bronchi. Serotonin 226-235 PCNA clamp associated factor Rattus norvegicus 0-3 19244313-0 2009 Serotonin induces Rho/ROCK-dependent activation of Smads 1/5/8 in pulmonary artery smooth muscle cells. Serotonin 0-9 SMAD family member 5 Bos taurus 51-62 19496825-3 2009 A functional polymorphism 68G>C (Cys23Ser) and a promoter polymorphism-995G>A of serotonin receptor 2C (HTR2C) have already been investigated, but no associations with suicide were determined. Serotonin 81-90 5-hydroxytryptamine receptor 2C Homo sapiens 104-109 7838128-1 1995 In the CA1 region of the hippocampus, activation of serotonin receptors of the 5-hydroxytryptamine (5-HT)4 subtype increases membrane excitability by reducing the calcium-activated potassium current responsible for the slow afterhyperpolarization observed in these cells. Serotonin 79-98 carbonic anhydrase 1 Homo sapiens 7-10 25346645-6 2009 Significant interaction and reversal effects between KA and the serotonin/2A (5-HT2A) system - the serotonin sub-type associated with classical psychedelics - were observed in three BPM measures. Serotonin 64-73 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 78-84 7838128-8 1995 Together, these results indicate that serotonin reduces the afterhyperpolarization in the CA1 region by acting on 5-HT4 receptors that increase intracellular cAMP levels and activate protein kinase A. Serotonin 38-47 carbonic anhydrase 1 Homo sapiens 90-93 19272410-1 2009 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. Serotonin 80-89 tryptophan hydroxylase 2 Homo sapiens 0-24 7995014-2 1994 Although not all features of its antiParkinson action are known, studies that used brains obtained at autopsy from patients who took l-deprenyl show that the selective inhibition of MAO-B with a concomitant increase of phenylethylamine and dopamine, but not of serotonin or noradrenaline, in the basal ganglia may be responsible for its mode of action. Serotonin 261-270 monoamine oxidase B Homo sapiens 182-187 19272410-1 2009 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. Serotonin 80-89 tryptophan hydroxylase 2 Homo sapiens 26-30 7814348-1 1994 BACKGROUND: Central serotonin depletion may contribute to the anxiety, restlessness, irritability, and affective disturbance seen in a variety of psychiatric conditions, particularly dementia of the Alzheimer"s type (DAT) in which brain concentrations of both 5-hydroxytryptamine (5-HT) and its 5-hydroxyindoleacetic acid (5-HIAA) metabolite are reduced. Serotonin 20-29 solute carrier family 6 member 3 Homo sapiens 217-220 19429102-1 2009 Exposure of rats to unpredictable loud sound pulses increases activity of the rate-limiting enzyme for serotonin synthesis, tryptophan hydroxylase (TPH), in the median raphe nucleus (MnR) and a mesolimbocortical serotonergic system. Serotonin 103-112 tryptophan hydroxylase 1 Rattus norvegicus 124-146 19429102-1 2009 Exposure of rats to unpredictable loud sound pulses increases activity of the rate-limiting enzyme for serotonin synthesis, tryptophan hydroxylase (TPH), in the median raphe nucleus (MnR) and a mesolimbocortical serotonergic system. Serotonin 103-112 tryptophan hydroxylase 1 Rattus norvegicus 148-151 7814348-1 1994 BACKGROUND: Central serotonin depletion may contribute to the anxiety, restlessness, irritability, and affective disturbance seen in a variety of psychiatric conditions, particularly dementia of the Alzheimer"s type (DAT) in which brain concentrations of both 5-hydroxytryptamine (5-HT) and its 5-hydroxyindoleacetic acid (5-HIAA) metabolite are reduced. Serotonin 260-279 solute carrier family 6 member 3 Homo sapiens 217-220 7814348-1 1994 BACKGROUND: Central serotonin depletion may contribute to the anxiety, restlessness, irritability, and affective disturbance seen in a variety of psychiatric conditions, particularly dementia of the Alzheimer"s type (DAT) in which brain concentrations of both 5-hydroxytryptamine (5-HT) and its 5-hydroxyindoleacetic acid (5-HIAA) metabolite are reduced. Serotonin 281-285 solute carrier family 6 member 3 Homo sapiens 217-220 7964734-2 1994 Endogenous PAF levels, determined by a bioassay using PAF-stimulated platelet release of [3H]serotonin, averaged 2.32 +/- 2.14 pg/mg in control brains and was reduced to 1.10 +/- 1.06 pg/mg after 20 min of maternal-fetal blood flow occlusion. Serotonin 93-102 PCNA clamp associated factor Rattus norvegicus 11-14 19356604-2 2009 Tryptophan hydroxylase isoform 2 (TPH2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. Serotonin 99-108 tryptophan hydroxylase 2 Homo sapiens 0-32 19356604-2 2009 Tryptophan hydroxylase isoform 2 (TPH2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. Serotonin 99-108 tryptophan hydroxylase 2 Homo sapiens 34-38 7964734-2 1994 Endogenous PAF levels, determined by a bioassay using PAF-stimulated platelet release of [3H]serotonin, averaged 2.32 +/- 2.14 pg/mg in control brains and was reduced to 1.10 +/- 1.06 pg/mg after 20 min of maternal-fetal blood flow occlusion. Serotonin 93-102 PCNA clamp associated factor Rattus norvegicus 54-57 7821394-0 1994 The neurotrophins NT-4/5 and BDNF augment serotonin, dopamine, and GABAergic systems during behaviorally effective infusions to the substantia nigra. Serotonin 42-51 neurotrophin 4 Rattus norvegicus 18-24 19318153-8 2009 The response to serotonin in males and to thromboxane in females was lower in the HF sFlt-1 and HF mFc groups. Serotonin 16-25 FMS-like tyrosine kinase 1 Mus musculus 85-91 7821394-0 1994 The neurotrophins NT-4/5 and BDNF augment serotonin, dopamine, and GABAergic systems during behaviorally effective infusions to the substantia nigra. Serotonin 42-51 brain-derived neurotrophic factor Rattus norvegicus 29-33 7824037-1 1994 The hypothesis that 5-hydroxytryptamine (5-HT) acting through 5-HT2C receptors is a key factor in the initiation of migraine has been re-evaluated in the light of recent basic and clinical scientific developments. Serotonin 20-39 5-hydroxytryptamine receptor 2C Homo sapiens 62-68 18936914-11 2009 CONCLUSION: These data suggest that CB1 antagonists may prevent locomotor sensitization to nicotine and reverse nicotine-induced elevations in hippocampal 5HT in high novelty seekers. Serotonin 155-158 cannabinoid receptor 1 Rattus norvegicus 36-39 7520441-7 1994 We demonstrate that the secondary wave of platelet aggregation and serotonin secretion induced by epinephrine and ADP, but not by the thromboxane analog U46619, was augmented by KL/SCF. Serotonin 67-76 KIT ligand Homo sapiens 178-180 18983874-5 2009 One class of genes regulated by both BDNF and serotonin (5-HT) are neuropeptides including VGF (non-acryonimic) which has a novel role in depression. Serotonin 46-55 VGF nerve growth factor inducible Homo sapiens 91-94 18973248-2 2009 Therefore, the neurotransmitter transporter genes, SLC6A3 (dopamine) and SLC6A4 (serotonin) are candidates for depression in PD. Serotonin 81-90 solute carrier family 6 member 3 Homo sapiens 51-57 7520441-7 1994 We demonstrate that the secondary wave of platelet aggregation and serotonin secretion induced by epinephrine and ADP, but not by the thromboxane analog U46619, was augmented by KL/SCF. Serotonin 67-76 KIT ligand Homo sapiens 181-184 7805767-0 1994 5-HT1D receptor type is involved in stimulation of cell proliferation by serotonin in human small cell lung carcinoma. Serotonin 73-82 5-hydroxytryptamine receptor 1D Homo sapiens 0-6 19218753-4 2009 At 1 to 3 wk after birth, brain levels of DA, DOPAC, HVA, 5HT and 5HIAA in PCB-exposed groups were higher than those of the control group. Serotonin 58-61 pyruvate carboxylase Rattus norvegicus 75-78 8049200-8 1994 Primary ADP-induced aggregation was not affected by cholesterol feeding or chronic ethanol intake, but thrombin-induced aggregation and secretion of [14C]serotonin from prelabeled platelets, which were enhanced by cholesterol feeding, were diminished by administration of ethanol to hypercholesterolemic rabbits. Serotonin 154-163 prothrombin Oryctolagus cuniculus 103-111 18835308-0 2008 Stimulation by neurotensin of dopamine and 5-hydroxytryptamine (5-HT) release from rat prefrontal cortex: possible role of NTR1 receptors in neuropsychiatric disorders. Serotonin 43-62 neurotensin Rattus norvegicus 15-26 18835308-1 2008 The modulation of cortical dopaminergic and serotonergic neurotransmissions by neurotensin (NT) was studied by measuring the release of dopamine (DA) and 5-hydroxytryptamine (5-HT) from the prefrontal cortex (PFC) of freely moving rats. Serotonin 154-173 neurotensin Rattus norvegicus 79-90 19067259-2 2008 Although platelet monoamine oxidase activity (MAO-B) has been proposed as an index of cerebral serotonin activity, studies in patients with AN are scarce. Serotonin 95-104 monoamine oxidase B Homo sapiens 46-51 7957607-1 1994 Electrophysiological studies have suggested that a subpopulation of interneurons near the border of layer II and III in rat piriform cortex are excited by serotonin (5-hydroxytryptamine; 5-HT) via 5-HT2A (formerly 5-HT2) rather than 5-HT2C (formerly 5-HT1C) receptors. Serotonin 155-164 5-hydroxytryptamine receptor 2C Rattus norvegicus 233-239 7957607-1 1994 Electrophysiological studies have suggested that a subpopulation of interneurons near the border of layer II and III in rat piriform cortex are excited by serotonin (5-hydroxytryptamine; 5-HT) via 5-HT2A (formerly 5-HT2) rather than 5-HT2C (formerly 5-HT1C) receptors. Serotonin 155-164 5-hydroxytryptamine receptor 2C Rattus norvegicus 250-256 7957607-1 1994 Electrophysiological studies have suggested that a subpopulation of interneurons near the border of layer II and III in rat piriform cortex are excited by serotonin (5-hydroxytryptamine; 5-HT) via 5-HT2A (formerly 5-HT2) rather than 5-HT2C (formerly 5-HT1C) receptors. Serotonin 166-185 5-hydroxytryptamine receptor 2C Rattus norvegicus 233-239 18722360-0 2008 Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized rat. Serotonin 83-92 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 47-52 20467835-3 2010 Magel2 gene knockout mice showed altered concentrations of both dopamine and serotonin in several parts of the brain compared with controls. Serotonin 77-86 MAGE family member L2 Mus musculus 0-6 7957607-1 1994 Electrophysiological studies have suggested that a subpopulation of interneurons near the border of layer II and III in rat piriform cortex are excited by serotonin (5-hydroxytryptamine; 5-HT) via 5-HT2A (formerly 5-HT2) rather than 5-HT2C (formerly 5-HT1C) receptors. Serotonin 166-185 5-hydroxytryptamine receptor 2C Rattus norvegicus 250-256 7922518-1 1994 We evaluated the effects of adrenalectomy (ADX) and replacement with glucocorticoid receptor agonists on serotonin (5-HT) 5-HT1A and 5-HT2 receptor binding in rat brain. Serotonin 105-114 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 69-92 20739005-1 2010 LeuT is a member of the neurotransmitter/sodium symporter family, which includes the neuronal transporters for serotonin, norepinephrine, and dopamine. Serotonin 111-120 Leucine transport, high Homo sapiens 0-4 18234415-2 2008 Recently some molecular genetic studies reported associations between a functional promoter polymorphism of the tryptophan hydroxylase 2 gene (TPH2), that regulates the synthesis of serotonin, and attention. Serotonin 182-191 tryptophan hydroxylase 2 Homo sapiens 112-136 18234415-2 2008 Recently some molecular genetic studies reported associations between a functional promoter polymorphism of the tryptophan hydroxylase 2 gene (TPH2), that regulates the synthesis of serotonin, and attention. Serotonin 182-191 tryptophan hydroxylase 2 Homo sapiens 143-147 18840973-2 2008 They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. Serotonin 59-68 solute carrier family 6 member 2 Canis lupus familiaris 95-101 8075479-3 1994 Serotonin-IR was demonstrable in the carotid bodies of adult humans and it was coexpressed mostly with synaptophysin or PGP 9.5 in type I cells. Serotonin 0-9 synaptophysin Homo sapiens 103-116 7515401-1 1994 In mammals, a large proportion of the bulbospinal 5-hydroxytryptamine (5-HT) neurons also contain neuropeptides, such as substance P (SP) and galanin (GAL). Serotonin 50-69 tachykinin precursor 1 S homeolog Xenopus laevis 121-132 18537141-2 2008 Noggin antagonism of BMP signaling increased total numbers of enteric neurons and those of subpopulations derived from precursors that exit the cell cycle early in neurogenesis (serotonin, calretinin, calbindin). Serotonin 178-187 noggin Mus musculus 0-6 20092861-1 2010 Receptors of the 5-HT2C subtype are of importance for the influence of serotonin on food intake, and 2 single nucleotide polymorphisms in this gene (HTR2C)--Cys23Ser (rs6318) and -759C>T (rs3813929)--have been reported to be associated with weight and/or antipsychotic-induced weight gain. Serotonin 71-80 5-hydroxytryptamine receptor 2C Homo sapiens 17-23 20092861-1 2010 Receptors of the 5-HT2C subtype are of importance for the influence of serotonin on food intake, and 2 single nucleotide polymorphisms in this gene (HTR2C)--Cys23Ser (rs6318) and -759C>T (rs3813929)--have been reported to be associated with weight and/or antipsychotic-induced weight gain. Serotonin 71-80 5-hydroxytryptamine receptor 2C Homo sapiens 149-154 8015380-1 1994 Tryptophan hydroxylase (TPH) is the first and presumably rate-limiting enzyme in serotonin (5-HT) biosynthesis. Serotonin 81-90 tryptophan hydroxylase 1 Rattus norvegicus 0-22 18400843-2 2008 We hypothesize that stimulation of 5-HT(2A) receptors in neurons activates TGase, resulting in transamidation of serotonin to a small G protein, Rac1, thereby constitutively activating Rac1. Serotonin 113-122 Rac family small GTPase 1 Homo sapiens 145-149 18400843-2 2008 We hypothesize that stimulation of 5-HT(2A) receptors in neurons activates TGase, resulting in transamidation of serotonin to a small G protein, Rac1, thereby constitutively activating Rac1. Serotonin 113-122 Rac family small GTPase 1 Homo sapiens 185-189 18400843-7 2008 Time course studies demonstrate that transamidation of Rac1 is significantly elevated after 5 and 15 min of serotonin treatment, but returns it to control levels after 30 min. Serotonin 108-117 Rac family small GTPase 1 Homo sapiens 55-59 8015380-1 1994 Tryptophan hydroxylase (TPH) is the first and presumably rate-limiting enzyme in serotonin (5-HT) biosynthesis. Serotonin 81-90 tryptophan hydroxylase 1 Rattus norvegicus 24-27 18400843-8 2008 The activity of Rac1 is also transiently increased following serotonin stimulation. Serotonin 61-70 Rac family small GTPase 1 Homo sapiens 16-20 18400843-10 2008 Serotonin itself is bound to Rac1 by TGase following 5-HT(2A) receptor stimulation as demonstrated by coimmunoprecipitation experiments and a dose-dependent decrease of serotonin-associated Rac1 by cystamine. Serotonin 0-9 Rac family small GTPase 1 Homo sapiens 29-33 20488463-1 2010 Melatonin is synthesized from serotonin by the action of arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole-O-methyltransferase. Serotonin 30-39 aralkylamine N-acetyltransferase Homo sapiens 57-91 20488463-1 2010 Melatonin is synthesized from serotonin by the action of arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole-O-methyltransferase. Serotonin 30-39 aralkylamine N-acetyltransferase Homo sapiens 93-98 20488463-1 2010 Melatonin is synthesized from serotonin by the action of arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole-O-methyltransferase. Serotonin 30-39 acetylserotonin O-methyltransferase Homo sapiens 104-137 8074747-0 1994 Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine. Serotonin 84-93 brain-derived neurotrophic factor Rattus norvegicus 0-33 18172756-0 2008 BDNF level in the rat prefrontal cortex increases following chronic but not acute treatment with duloxetine, a dual acting inhibitor of noradrenaline and serotonin re-uptake. Serotonin 154-163 brain-derived neurotrophic factor Rattus norvegicus 0-4 7984276-0 1994 A single point mutation increases the affinity of serotonin 5-HT1D alpha, 5-HT1D beta, 5-HT1E and 5-HT1F receptors for beta-adrenergic antagonists. Serotonin 50-59 5-hydroxytryptamine receptor 1D Homo sapiens 60-72 18172756-2 2008 The brain level of BDNF is changed by several mood stabilizers and antidepressant drugs acting on neurotransmitters such as noradrenaline and serotonin. Serotonin 142-151 brain-derived neurotrophic factor Rattus norvegicus 19-23 20570529-0 2010 Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes. Serotonin 133-142 5-hydroxytryptamine receptor 2C Homo sapiens 159-165 7984276-0 1994 A single point mutation increases the affinity of serotonin 5-HT1D alpha, 5-HT1D beta, 5-HT1E and 5-HT1F receptors for beta-adrenergic antagonists. Serotonin 50-59 5-hydroxytryptamine receptor 1F Homo sapiens 98-104 18197473-2 2008 Two isoforms of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, TPH1 and TPH2, are known. Serotonin 44-53 tryptophan hydroxylase 1 Rattus norvegicus 92-96 8301563-1 1994 5-Hydroxytryptamine (5-HT) 5-HT2c receptors mediate the enhanced oral activity response to the dopamine (DA) D1 agonist, (+/-)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol (SKF 38393) in neonatal 6-hydroxydopamine (6-OHDA)-lesioned rats. Serotonin 1-19 5-hydroxytryptamine receptor 2C Rattus norvegicus 27-33 18197473-2 2008 Two isoforms of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, TPH1 and TPH2, are known. Serotonin 44-53 tryptophan hydroxylase 2 Rattus norvegicus 101-105 18310473-5 2008 We confirmed that TAAR1 was activated by dopamine, norepinephrine, and serotonin and demonstrated that TAAR1 signaling was attenuated by monoamine autoreceptors at exposure to dopamine, norepinephrine, and serotonin. Serotonin 206-215 trace amine associated receptor 1 Homo sapiens 18-23 18310473-5 2008 We confirmed that TAAR1 was activated by dopamine, norepinephrine, and serotonin and demonstrated that TAAR1 signaling was attenuated by monoamine autoreceptors at exposure to dopamine, norepinephrine, and serotonin. Serotonin 206-215 trace amine associated receptor 1 Homo sapiens 103-108 18310473-6 2008 In transfected cells, TAAR1 in response to dopamine, norepinephrine, and serotonin significantly inhibited uptake and promoted efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin, respectively, whereas the monoamine autoreceptors, D2s, alpha(2A), and 5-HT(1B) enhanced the uptake function under the same condition. Serotonin 73-82 trace amine associated receptor 1 Homo sapiens 22-27 18310473-6 2008 In transfected cells, TAAR1 in response to dopamine, norepinephrine, and serotonin significantly inhibited uptake and promoted efflux of [3H]dopamine, [3H]norepinephrine, and [3H]serotonin, respectively, whereas the monoamine autoreceptors, D2s, alpha(2A), and 5-HT(1B) enhanced the uptake function under the same condition. Serotonin 179-188 trace amine associated receptor 1 Homo sapiens 22-27 19823180-8 2010 Double immunocytochemistry for TUNEL and tryptophan hydroxylase (TPH) indicated that DNA fragmentation was prominent in serotonin neurons. Serotonin 120-129 tryptophan hydroxylase 1 Macaca mulatta 41-63 19823180-8 2010 Double immunocytochemistry for TUNEL and tryptophan hydroxylase (TPH) indicated that DNA fragmentation was prominent in serotonin neurons. Serotonin 120-129 tryptophan hydroxylase 1 Macaca mulatta 65-68 19637400-8 2010 The second finding is novel and might be accounted for by BDNF-mediated serotonin or dopamine pathways. Serotonin 72-81 brain derived neurotrophic factor Homo sapiens 58-62 8245704-1 1993 A peptide homologous to a region of murine granulocyte-macrophage colony-stimulating factor (mGM-CSF), P27-38, which was shown to be a GM-CSF antagonist, inhibited the function of serotonin release from murine mast cells. Serotonin 180-189 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 43-91 19800635-9 2010 The present results suggest that the combination of high environmental stress and low CNS serotonin function could contribute to atherogenesis through processes that lead to increased expression of the beta(2)-integrins CD11b and CD11c on monocyte cell surfaces. Serotonin 90-99 integrin subunit alpha M Homo sapiens 220-225 8245704-1 1993 A peptide homologous to a region of murine granulocyte-macrophage colony-stimulating factor (mGM-CSF), P27-38, which was shown to be a GM-CSF antagonist, inhibited the function of serotonin release from murine mast cells. Serotonin 180-189 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 93-100 17604842-2 2008 TPH2 is a recently discovered isoform that is expressed predominantly in serotonin neurons. Serotonin 73-82 tryptophan hydroxylase 2 Homo sapiens 0-4 8288316-2 1993 The first approach showed that pretreatment of mice with p-cholorphenylalanine (PCPA) to deplete intracellular stores of serotonin reduced the capacity of their splenic T cells to proliferate and to express interleukin-2 receptor (IL-2R) in response to concanavalin A (Con A). Serotonin 121-130 interleukin 2 receptor, alpha chain Mus musculus 207-229 8288316-2 1993 The first approach showed that pretreatment of mice with p-cholorphenylalanine (PCPA) to deplete intracellular stores of serotonin reduced the capacity of their splenic T cells to proliferate and to express interleukin-2 receptor (IL-2R) in response to concanavalin A (Con A). Serotonin 121-130 interleukin 2 receptor, alpha chain Mus musculus 231-236 20165787-1 2010 UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements. Serotonin 45-54 translocator protein Homo sapiens 242-245 8214946-11 1993 Moreover, NEP also affects the airway histamine and serotonin release caused by these tachykinins in the Fisher 344 rat. Serotonin 52-61 membrane metallo-endopeptidase Rattus norvegicus 10-13 20163460-7 2010 Like loss of HO-1, loss of p21(WAF1) through siRNA transfection also reversed the inhibitory effect of rosiglitazone on PASMC proliferation triggered by serotonin. Serotonin 153-162 KRAS proto-oncogene, GTPase Rattus norvegicus 27-30 17972101-1 2008 Tryptophan hydroxylase-2 (TPH2) is a recently identified TPH isoform responsible for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a range of behavioral traits and psychiatric disorders. Serotonin 94-103 tryptophan hydroxylase 2 Homo sapiens 0-24 17972101-1 2008 Tryptophan hydroxylase-2 (TPH2) is a recently identified TPH isoform responsible for neuronal serotonin (5-HT) synthesis, and TPH2 polymorphisms are associated with a range of behavioral traits and psychiatric disorders. Serotonin 94-103 tryptophan hydroxylase 2 Homo sapiens 26-30 8223911-5 1993 The effect of 1 microM serotonin on channel activity was inhibited by ritanserin (30 and 100 nM) which has a high affinity for serotonin 5-HT1C receptors and 5-HT2 receptors. Serotonin 23-32 5-hydroxytryptamine receptor 2C Rattus norvegicus 137-143 17917719-2 2008 Tacrine is a centrally acting, reversible cholinesterase inhibitor that also inhibits monoamine oxidase (MAO) and blocks reuptake of dopamine (DA) and serotonin. Serotonin 151-160 butyrylcholinesterase Rattus norvegicus 42-56 17568567-1 2007 BACKGROUND: Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin (5-HT) biosynthesis. Serotonin 81-90 tryptophan hydroxylase 2 Homo sapiens 12-36 17568567-1 2007 BACKGROUND: Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin (5-HT) biosynthesis. Serotonin 81-90 tryptophan hydroxylase 2 Homo sapiens 38-42 20113875-6 2010 Furthermore, genetic variants that alter functioning of the serotonin, endogenous opioid, and corticotropin-releasing hormone systems are shown to influence both physiological and behavioral outcomes, in some cases interacting with early experience to indicate gene by environment interactions. Serotonin 60-69 corticotropin releasing hormone Macaca mulatta 94-125 8223911-7 1993 These data suggest that serotonin increases Cl- channel activity by acting on the 5-HT1C receptors on the epithelium. Serotonin 24-33 5-hydroxytryptamine receptor 2C Rattus norvegicus 82-88 20087163-3 2010 Using kidney mesangial cells we investigated whether profibrotic serotonin (5-HT) induces phosphorylation of ADAM-17 with concomitant increase in the enzyme activity. Serotonin 65-74 ADAM metallopeptidase domain 17 Homo sapiens 109-116 7901378-1 1993 The effect of platelet activating factor (PAF) on contractions evoked by acetylcholine, 5-hydroxytryptamine (5-HT) and prostaglandin E2 (PGE2) was studied in-vitro on rat stomach strip. Serotonin 88-107 PCNA clamp associated factor Rattus norvegicus 42-45 19995401-1 2010 BACKGROUND: A possible role of 5-hydroxytryptamine (5-HT) in the origin of antigen-induced airway hyperresponsiveness (AI-AHR) has been scarcely investigated. Serotonin 31-50 aryl hydrocarbon receptor Cavia porcellus 122-125 17613521-1 2007 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of TPH2 are implicated in vulnerability to psychiatric disorders. Serotonin 69-78 tryptophan hydroxylase 2 Homo sapiens 0-24 17613521-1 2007 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of TPH2 are implicated in vulnerability to psychiatric disorders. Serotonin 69-78 tryptophan hydroxylase 2 Homo sapiens 26-30 17613521-1 2007 Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of TPH2 are implicated in vulnerability to psychiatric disorders. Serotonin 69-78 tryptophan hydroxylase 2 Homo sapiens 114-118 7901378-1 1993 The effect of platelet activating factor (PAF) on contractions evoked by acetylcholine, 5-hydroxytryptamine (5-HT) and prostaglandin E2 (PGE2) was studied in-vitro on rat stomach strip. Serotonin 109-113 PCNA clamp associated factor Rattus norvegicus 42-45 20134153-8 2010 Fibers containing NPY-ir and serotonin (5-HT)-ir were most concentrated in the areas containing VIP-ir and CalB-ir cells, respectively. Serotonin 29-38 calbindin 1 Mus musculus 107-111 17768266-1 2007 CONTEXT: The tryptophan hydroxylase 2 (TPH2) gene encodes the first (also the rate-limiting) enzyme in the serotonin biosynthetic pathway. Serotonin 107-116 tryptophan hydroxylase 2 Homo sapiens 13-37 8402156-12 1993 The modulation of these channels by serotonin may be important to CSF secretion and its regulation. Serotonin 36-45 colony stimulating factor 2 (granulocyte-macrophage) Mus musculus 66-69 17768266-1 2007 CONTEXT: The tryptophan hydroxylase 2 (TPH2) gene encodes the first (also the rate-limiting) enzyme in the serotonin biosynthetic pathway. Serotonin 107-116 tryptophan hydroxylase 2 Homo sapiens 39-43 8325896-4 1993 Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in isoprenoid and sterol biosynthesis, by the cholesterol-lowering drug, lovastatin, blocks Fc epsilon RI-dependent [3H] serotonin ([3H]5HT) release from the mast cell line, RBL-2H3. Serotonin 219-228 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 14-71 17854596-0 2007 Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors. Serotonin 10-19 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 100-106 19475557-9 2010 Coexpression of UGT2B7 also affected the kinetics of estradiol 3-O-glucuronidation by UGT1A1, imipramine N-glucuronidation by UGT1A4, serotonin O-glucuronidation by UGT1A6, and propofol O-glucuronidation by UGT1A9. Serotonin 134-143 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 16-22 20738025-2 2010 We studied the association between two polymorphisms (5-HTTLPR and Val66Met BDNF) and the platelet serotonin content in 47 patients with stroke. Serotonin 99-108 brain derived neurotrophic factor Homo sapiens 76-80 8325896-4 1993 Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in isoprenoid and sterol biosynthesis, by the cholesterol-lowering drug, lovastatin, blocks Fc epsilon RI-dependent [3H] serotonin ([3H]5HT) release from the mast cell line, RBL-2H3. Serotonin 234-237 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 14-71 19812368-5 2009 ROS production and the suppression of Cdc42GAP activity in response to stimulation with 5-hydroxytryptamine (5-HT) were attenuated in cells producing p47(phox) shRNA compared with cells producing luciferase shRNA. Serotonin 88-107 Rho GTPase activating protein 1 Homo sapiens 38-46 17603158-5 2007 These results suggest that both initial inflammatory mediators (serotonin and histamine) and later inflammatory mediators (prostaglandin and bradykinin) are involved in the anti-inflammatory effects of AGP. Serotonin 64-73 orosomucoid 1 Rattus norvegicus 202-205 8361548-1 1993 The regional distribution and the pharmacology of the binding sites labelled with the novel 5-hydroxytryptamine (serotonin) 5-HT1B/1D selective radioligand serotonin-O-carboxy-methyl-glycyl-[125I]tyrosinamide (abbreviated [125I]GTI for the sake of simplicity) was determined using quantitative autoradiography in rat brain. Serotonin 92-111 5-hydroxytryptamine receptor 1B Rattus norvegicus 124-130 17532569-0 2007 In vitro effects of adrenomedullin and calcitonin gene related peptide on the release of serotonin and amino acids from rat dorsal spinal cord. Serotonin 89-98 adrenomedullin Rattus norvegicus 20-34 8361548-1 1993 The regional distribution and the pharmacology of the binding sites labelled with the novel 5-hydroxytryptamine (serotonin) 5-HT1B/1D selective radioligand serotonin-O-carboxy-methyl-glycyl-[125I]tyrosinamide (abbreviated [125I]GTI for the sake of simplicity) was determined using quantitative autoradiography in rat brain. Serotonin 113-122 5-hydroxytryptamine receptor 1B Rattus norvegicus 124-130 17346884-0 2007 CART peptides increase 5-hydroxytryptamine in the dorsal raphe and nucleus accumbens of freely behaving rats. Serotonin 23-42 CART prepropeptide Rattus norvegicus 0-4 17453063-1 2007 Tryptophan hydroxylase isoform 2 (TPH2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. Serotonin 181-190 tryptophan hydroxylase 2 Homo sapiens 0-32 17453063-1 2007 Tryptophan hydroxylase isoform 2 (TPH2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. Serotonin 181-190 tryptophan hydroxylase 2 Homo sapiens 34-38 19588223-1 2009 The rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase 2 (TPH2), is one of the most promising candidate genes for psychiatric disorders. Serotonin 28-37 tryptophan hydroxylase 2 Homo sapiens 52-76 19588223-1 2009 The rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase 2 (TPH2), is one of the most promising candidate genes for psychiatric disorders. Serotonin 28-37 tryptophan hydroxylase 2 Homo sapiens 78-82 8387861-1 1993 This study tests the effect of serotonin (5-HT) (1 microM) on the induction of long-term potentiation (LTP) at the commissural/associational (C/A)-CA3 synapse. Serotonin 31-40 carbonic anhydrase 3 Rattus norvegicus 147-150 17039513-5 2007 In this study, the ability of a novel platelet GPIIb/IIIa antagonist, a free acid form of roxifiban (XV459), to block platelet activation/aggregation in response to highly characterized heparin-PF4 antibody-positive plasma/heparin was examined using light transmittance aggregometry, serotonin release, and (125)I-fibrinogen binding assays to human platelets. Serotonin 284-293 integrin subunit alpha 2b Homo sapiens 47-52 8384716-10 1993 HeLa cells transfected with the MR77 gene exhibited inhibition of adenylate cyclase in response to serotonin. Serotonin 99-108 5-hydroxytryptamine receptor 1F Homo sapiens 32-36 17237153-4 2007 We found that coumarin 7-hydroxylation and cotinine 3"-hydroxylation by recombinant CYP2A6 expressed in baculovirus-infected insect cells were competitively inhibited by tryptamine (both K(i) = 0.2 microM), serotonin (K(i) = 252 microM and 167 microM), dopamine (K(i) = 49 microM and 22 microM), and histamine (K(i) = 428 microM and 359 microM). Serotonin 207-216 cytochrome P450 family 2 subfamily A member 6 Homo sapiens 84-90 8366770-2 1993 Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated the melatonin effect on the kinetic parameters of platelet 5HT uptake. Serotonin 108-111 proline rich protein 2-like 1 Rattus norvegicus 42-45 17346350-1 2007 BACKGROUND: The TPH2 gene encodes the enzyme responsible for serotonin (5-HT) synthesis in the Central Nervous System (CNS). Serotonin 61-70 tryptophan hydroxylase 2 Homo sapiens 16-20 8366770-2 1993 Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated the melatonin effect on the kinetic parameters of platelet 5HT uptake. Serotonin 246-249 proline rich protein 2-like 1 Rattus norvegicus 42-45 8446179-5 1993 The data suggest that 5-HT3 receptor antagonists prevent the release of CCK evoked by endogenous 5-hydroxytryptamine. Serotonin 97-116 cholecystokinin Rattus norvegicus 72-75 17181551-3 2007 Variants of TPH2 have recently reported to be associated with reduced serotonin production and behavioural alterations in man and mice. Serotonin 70-79 tryptophan hydroxylase 2 Homo sapiens 12-16 17287506-9 2007 Altogether, these results suggest that high levels of serotonin, acting through 5-HT2 receptors, have neuroprotective action on cortical neurons by controlling Bcl-X(L) mRNA levels and that this action is independent of trkB signaling. Serotonin 54-63 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 220-224 8072785-0 1993 [Comparative analysis of the effect of active immunization of rats with bovine serum albumin and serotonin-bovine serum albumin conjugate on brain biogenic amine levels and behavioral reactions]. Serotonin 97-106 albumin Rattus norvegicus 114-127 17142836-0 2007 Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells. Serotonin 60-69 ras homolog family member A Rattus norvegicus 27-31 17142836-2 2007 Here we analyze the mechanisms of RhoA regulation by serotonin (5-HT) in arterial smooth muscle. Serotonin 53-62 ras homolog family member A Rattus norvegicus 34-38 8072785-1 1993 The authors studied the effect of active immunization of rats with bovine serum albumin and serotonin-bovine serum albumin conjugate on the distribution of biogenic amines in the brain and the behaviour of the animals. Serotonin 92-101 albumin Rattus norvegicus 109-122 7831446-1 1993 There is considerable interest in the role of serotonin (5-HT) in the pathophysiology of schizophrenia and in the mechanism of action of clozapine, an atypical antipsychotic agent and a potent dopamine (DA), 5-HT2/5-HT1C and histamine (H) antagonist. Serotonin 46-55 5-hydroxytryptamine receptor 2C Homo sapiens 214-220 16806108-3 2007 These data suggest that polymorphisms in both the serotonin 1D (HTR1D) and opioid delta 1 (OPRD1) receptor genes show a significant association with restricting AN (RAN). Serotonin 50-59 5-hydroxytryptamine receptor 1D Homo sapiens 64-69 7678181-5 1993 The biogenic amine serotonin abrogated monocyte-induced suppression of NK-cell functions as well as down-modulation of CD16/56 NK-cell antigen. Serotonin 19-28 Fc gamma receptor IIIa Homo sapiens 119-123 17102981-11 2007 CONCLUSIONS: Combined 5-HT and opioid properties result in a greater efficacy in antagonizing 5-HT2A-related behavior. Serotonin 22-26 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 94-100 17123708-1 2007 Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Serotonin 83-92 tryptophan hydroxylase 2 Homo sapiens 0-24 1334504-0 1992 Serotonin agonists increase transferrin levels via activation of 5-HT1C receptors in choroid plexus epithelium. Serotonin 0-9 5-hydroxytryptamine receptor 2C Rattus norvegicus 65-71 17123708-1 2007 Tryptophan Hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. Serotonin 83-92 tryptophan hydroxylase 2 Homo sapiens 26-30 17113567-8 2007 Here we describe specific genetic interaction between tax-6 and kin-29 in regulating body size, serotonin mediated egg laying, and chemoreceptor expression. Serotonin 96-105 Serine/threonine-protein kinase kin-29 Caenorhabditis elegans 64-70 17241888-5 2007 Serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, TpH1 and TpH2, which are found, respectively, in EC cells and neurons. Serotonin 0-9 tryptophan hydroxylase 2 Homo sapiens 94-98 1448490-2 1992 We examined the effect of pretreatment with the CCK-A antagonist devazepide (DVZ) on anorexia produced by peripheral administration of serotonin [5-hydroxytryptamine (5-HT)] or CCK-8 in 3-h food-deprived rats consuming a 30-min test meal of sweetened mash. Serotonin 135-144 cholecystokinin Rattus norvegicus 48-51 1481137-0 1992 Reduction of GABAB inhibitory postsynaptic potentials by serotonin via pre- and postsynaptic mechanisms in CA3 pyramidal cells of rat hippocampus in vitro. Serotonin 57-66 carbonic anhydrase 3 Rattus norvegicus 107-110 17146777-1 2007 Although serotonin (5-HT) is an important neuromodulator in the superficial layers of the medial entorhinal cortex (mEC), there is some disagreement concerning its influences upon the membrane properties of neurons within this region. Serotonin 9-18 chemokine (C-C motif) ligand 28 Mus musculus 116-119 17146777-9 2007 Serotonin is thus likely to influence, in a composite fashion, the information processing of Layer II neurons in the mEC and thus, the passage of neocortical information via the perforant pathway to the hippocampus. Serotonin 0-9 chemokine (C-C motif) ligand 28 Mus musculus 117-120 17099886-3 2006 Serotonin-1D receptors are autoreceptors which can regulate the release of serotonin in brain, so the HTR1D gene may be predisposing. Serotonin 75-84 5-hydroxytryptamine receptor 1D Homo sapiens 102-107 16940330-8 2006 Similar to activation of Epac1, stimulation of cells with serotonin to induce cAMP production resulted in Rap1 activation, increased cell adhesion and polarization, and enhanced chemotaxis. Serotonin 58-67 Rap guanine nucleotide exchange factor 3 Homo sapiens 25-30 1481137-1 1992 The action of serotonin (5-HT) on GABAergic synaptic transmission was investigated with intracellular recordings in CA3 pyramidal cells of rat hippocampal slices. Serotonin 14-23 carbonic anhydrase 3 Rattus norvegicus 116-119 16940330-9 2006 The effects of serotonin on U937 cell adhesion were dependent on cAMP production but could not be blocked by a protein kinase A inhibitor, implicating Epac in the regulation of serotonin-induced adhesion. Serotonin 15-24 Rap guanine nucleotide exchange factor 3 Homo sapiens 151-155 1467932-1 1992 This study was designed to assess the effects of the 5-hydroxytryptamine (5-HT) indirect agonist fenfluramine on the brain distribution of Fos- and corticotropin-releasing factor-like immunoreactivity (F-LI and CRF-LI). Serotonin 53-72 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 139-142 16940330-9 2006 The effects of serotonin on U937 cell adhesion were dependent on cAMP production but could not be blocked by a protein kinase A inhibitor, implicating Epac in the regulation of serotonin-induced adhesion. Serotonin 177-186 Rap guanine nucleotide exchange factor 3 Homo sapiens 151-155 1333968-1 1992 Endocrine responses to the serotonin (5-HT) 5-HT1C/5-HT2 agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) were utilised to evaluate cocaine-induced alterations in postsynaptic 5-HT receptor function. Serotonin 27-36 5-hydroxytryptamine receptor 2C Rattus norvegicus 44-50 17192569-7 2006 injection of synthetic double-stranded RNAs, polyriboinosinic: polyribocytidylic acid (poly I:C) in rats, we show an involvement of brain interferon-alpha (IFN-alpha) and serotonin (5-HT) transporter (5-HTT) in the central mechanisms of fatigue. Serotonin 171-180 huntingtin Rattus norvegicus 203-206 1422584-2 1992 Despite the fact that 5-hydroxytryptamine (5-HT)-induced contractions of the rabbit isolated renal artery are mediated by a receptor belonging to the heterogeneous 5-HT1-like category, we observed that the so-called selective 5-HT3 receptor agonist, 2-methyl-5-HT, caused a concentration-dependent contraction of this vessel. Serotonin 22-41 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 164-174 17067154-5 2006 Barettin selectively interacted with the serotonin receptors 5-HT2A, 5-HT2C, and 5-HT4 at concentrations close to that of endogenous serotonin, with the corresponding Ki values being 1.93, 0.34, and 1.91 microM, respectively. Serotonin 41-50 5-hydroxytryptamine receptor 2C Homo sapiens 69-75 19956756-0 2009 Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice. Serotonin 8-17 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 22-28 16487493-0 2006 Low cerebrospinal fluid transthyretin levels in depression: correlations with suicidal ideation and low serotonin function. Serotonin 104-113 transthyretin Homo sapiens 24-37 1409786-0 1992 Further evidence showing that the inhibitory action of serotonin on rat masculine sexual behavior is mediated after the stimulation of 5-HT1B receptors. Serotonin 55-64 5-hydroxytryptamine receptor 1B Rattus norvegicus 135-141 17003259-0 2006 Serotonin stimulates GnRH secretion through the c-Src-PLC gamma1 pathway in GT1-7 hypothalamic cells. Serotonin 0-9 phospholipase C, gamma 1 Mus musculus 54-64 17003259-3 2006 In this study, we report that serotonin activates phospholipase C (PLC) gamma1 in an Src-dependent manner in hypothalamic GT1-7 cells, and that pretreatment with either 4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazole [3, 4-d] pyrimidine, an Src-kinase inhibitor, or U73122, a PLC inhibitor, attenuates the serotonin-induced increase in calcium levels. Serotonin 30-39 phospholipase C, gamma 1 Mus musculus 50-78 17003259-4 2006 Also, PLC gamma1 binds to c-Src through the Src-homology (SH) 223 domain upon serotonin treatment. Serotonin 78-87 phospholipase C, gamma 1 Mus musculus 6-16 19748542-2 2009 The newly identified neuronal tryptophan hydroxylase isoform 2 (TPH2), the rate-limiting enzyme in serotonin synthesis, represents a prime candidate in numerous genetic association analyses of suicidal behavior; however, the results are still inconclusive. Serotonin 99-108 tryptophan hydroxylase 2 Homo sapiens 64-68 17003259-7 2006 In addition, the results of our small-interfering RNA experiment confirm that endogenous PLC gamma1 is a prerequisite for serotonin-mediated signaling pathways. Serotonin 122-131 phospholipase C, gamma 1 Mus musculus 89-99 1351370-3 1992 Paraneurons containing 5-hydroxytryptamine colocalized with chromogranin A or cholecystokinin were also found in all subjects. Serotonin 23-42 chromogranin A Equus caballus 60-74 17003259-8 2006 Taken together, our findings demonstrate that serotonin stimulates the release of GnRH through the Src-PLC gamma1 pathway, via the modulation of intracellular calcium levels. Serotonin 46-55 phospholipase C, gamma 1 Mus musculus 103-113 19474802-3 2009 Recent studies suggest that cis-UCA binds to serotonin (5-hydroxytryptamine) 2A (5-HT(2A)) receptor and that antagonists of 5-HT(2A) and the platelet-activating factor (PAF) receptor can block cis-UCA-induced immune suppression in mice. Serotonin 45-54 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 81-99 19474802-3 2009 Recent studies suggest that cis-UCA binds to serotonin (5-hydroxytryptamine) 2A (5-HT(2A)) receptor and that antagonists of 5-HT(2A) and the platelet-activating factor (PAF) receptor can block cis-UCA-induced immune suppression in mice. Serotonin 45-54 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 81-88 16146581-3 2006 The aim of this study was to investigate the effect of polymorphic variants in the gene of the novel brain-specific tryptophan hydroxylase-2 (TPH2), the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain, in OCD with disease onset in childhood and adolescence. Serotonin 177-186 tryptophan hydroxylase 2 Homo sapiens 116-140 1379825-3 1992 Serotonin-immunoreactive paraneurons were first detected in the pulmonary mesenchyma of 8-day-old embryos, while in the 12-day-old embryos the following neurons and paraneurons were first detected in their respective locations: serotonin-immunoreactive paraneurons in the bronchial epithelium; VIP- and galanin-immunoreactive ganglionic cells and SP-immunoreactive nerve fibres in the intrapulmonary ganglia. Serotonin 0-9 vasoactive intestinal peptide Gallus gallus 294-298 16146581-3 2006 The aim of this study was to investigate the effect of polymorphic variants in the gene of the novel brain-specific tryptophan hydroxylase-2 (TPH2), the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain, in OCD with disease onset in childhood and adolescence. Serotonin 177-186 tryptophan hydroxylase 2 Homo sapiens 142-146 18427560-2 2009 In that respect, several variants of the tryptophan hydroxylase gene (TPH2), which codes for the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), have been associated with ADHD. Serotonin 141-150 tryptophan hydroxylase 2 Homo sapiens 70-74 19652718-11 2009 Noteworthy, TNAP may contribute to the regulation of serotonin or catecholamine synthesis in 1C11(5-HT) and 1C11(NE) bioaminergic cells by controlling pyridoxal phosphate levels. Serotonin 53-62 alkaline phosphatase, liver/bone/kidney Mus musculus 12-16 1379862-8 1992 Comparison of these activities (NAT versus HIOMT) permits the suggestion that NAT is a limiting enzyme in serotonin metabolism in this tissue. Serotonin 106-115 bromodomain containing 2 Homo sapiens 32-35 19342454-0 2009 Influence of sex and corticotropin-releasing factor pathways as determinants in serotonin sensitivity. Serotonin 80-89 corticotropin releasing hormone Mus musculus 21-51 19342454-2 2009 Serotonin (5-HT) pathway recruitment by corticotropin-releasing factor (CRF) during stress is necessary in adaptive coping behaviors, but sex differences in such responses have not been investigated. Serotonin 0-9 corticotropin releasing hormone Mus musculus 40-70 16682118-3 2006 In the present study, we investigated the three serotonin-related genes, 5-HT(2C), 5-HT(6), and TPH1 genes, in relation to personality traits in the Japanese population. Serotonin 48-57 5-hydroxytryptamine receptor 2C Homo sapiens 73-80 16401665-7 2006 Moreover, a recently described loss-of-function mutation of TPH2 which results in an 80% reduction of serotonin production, was assessed. Serotonin 102-111 tryptophan hydroxylase 2 Homo sapiens 60-64 1379862-8 1992 Comparison of these activities (NAT versus HIOMT) permits the suggestion that NAT is a limiting enzyme in serotonin metabolism in this tissue. Serotonin 106-115 acetylserotonin O-methyltransferase Homo sapiens 43-48 1379862-8 1992 Comparison of these activities (NAT versus HIOMT) permits the suggestion that NAT is a limiting enzyme in serotonin metabolism in this tissue. Serotonin 106-115 bromodomain containing 2 Homo sapiens 78-81 1548463-1 1992 3-(1,2,5,6-Tetrahydro-4-pyridyl)-5-n-propoxyindole (CP-96,501) was found to be more selective ligand at the serotonin 5-HT1B receptor than the commonly used 5-HT1B agonist, 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-methoxyindole (RU 24969). Serotonin 108-117 5-hydroxytryptamine receptor 1B Rattus norvegicus 118-124 16927961-2 2006 Although the importance of serotonin to migraine tendency suggests a link between serotonergic signaling and CACNA1A function, the nature of this connection remains unclear in vertebrate studies. Serotonin 27-36 calcium voltage-gated channel subunit alpha1 A Homo sapiens 109-116 16927961-9 2006 The evolutionary and functional relationship between the UNC-2 channel and the migraine-associated CACNA1A channel was further confirmed through experiments showing that transgenic expression of human CACNA1A can suppress the lethargic and serotonin-deficient phenotypes of unc-2 mutant animals. Serotonin 240-249 calcium voltage-gated channel subunit alpha1 A Homo sapiens 99-106 16927961-9 2006 The evolutionary and functional relationship between the UNC-2 channel and the migraine-associated CACNA1A channel was further confirmed through experiments showing that transgenic expression of human CACNA1A can suppress the lethargic and serotonin-deficient phenotypes of unc-2 mutant animals. Serotonin 240-249 calcium voltage-gated channel subunit alpha1 A Homo sapiens 201-208 16927961-10 2006 The findings in this invertebrate model constitute the first direct demonstration of how CACNA1A function might affect the levels of serotonin, a neurotransmitter known to be important in migraine. Serotonin 133-142 calcium voltage-gated channel subunit alpha1 A Homo sapiens 89-96 16408289-8 2006 Proliferation of human mesenchymal stem cells (MSC) and primary osteoblasts (NHO), and 5-HT2A receptor expression was enhanced by serotonin. Serotonin 130-139 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 87-93 19570918-3 2009 Here, we investigate how Rac1 activity affects release of Ca(2+) from intracellular endoplasmic reticulum (ER) stores stimulated by application of serotonin (5-hydroxytriptamine). Serotonin 147-156 Rac family small GTPase 1 Homo sapiens 25-29 19570918-3 2009 Here, we investigate how Rac1 activity affects release of Ca(2+) from intracellular endoplasmic reticulum (ER) stores stimulated by application of serotonin (5-hydroxytriptamine). Serotonin 158-177 Rac family small GTPase 1 Homo sapiens 25-29 19433074-2 2009 The present study identified these neurons in cats by combining the transneuronal retrograde transport of rabies virus from the diaphragm with the immunohistochemical detection of the N-terminal region of tryptophan hydroxylase-2 (TPH2), the brain-specific isoform of the enzyme responsible for the initial and rate-limiting step in serotonin synthesis. Serotonin 333-342 tryptophan hydroxylase 2 Homo sapiens 231-235 16408289-11 2006 Serotonin-induced proliferation of MC3T3-E1 cells was inhibited by the PKC inhibitor (GF109203) and was also markedly reduced when antagonists of the serotonin receptors 5-HT2B/C or 5-HT2A/C were added. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 170-176 1548463-1 1992 3-(1,2,5,6-Tetrahydro-4-pyridyl)-5-n-propoxyindole (CP-96,501) was found to be more selective ligand at the serotonin 5-HT1B receptor than the commonly used 5-HT1B agonist, 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-methoxyindole (RU 24969). Serotonin 108-117 5-hydroxytryptamine receptor 1B Rattus norvegicus 157-163 16408289-11 2006 Serotonin-induced proliferation of MC3T3-E1 cells was inhibited by the PKC inhibitor (GF109203) and was also markedly reduced when antagonists of the serotonin receptors 5-HT2B/C or 5-HT2A/C were added. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 182-188 1738002-1 1992 There is a lack of radioactive probes, particularly radioiodinated probes, for the direct labeling of serotonin-1B (5-HT1B) and serotonin-1D (5-HT1D) binding sites. Serotonin 102-111 5-hydroxytryptamine receptor 1B Rattus norvegicus 116-122 16408289-12 2006 Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF-kappaB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast-induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect. Serotonin 0-9 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 20-35 16408289-12 2006 Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF-kappaB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast-induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect. Serotonin 0-9 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 37-40 19568484-2 2009 Animal and cell-culture experiments suggest multiple interrelations between BDNF and the serotonin (5-HT) system. Serotonin 89-98 brain derived neurotrophic factor Homo sapiens 76-80 1401336-6 1992 Compared with the effects of acetylcholine, serotonin and histamine, eel atrial natriuretic peptide was the most potent inhibitor, with 100% inhibition at 10(-7) M; 50% inhibition was obtained at 10(-2) M in acetylcholine, and 30% inhibition in serotonin (10(-5) M) and histamine (10(-3) M). Serotonin 44-53 natriuretic peptide A Rattus norvegicus 73-99 19344641-1 2009 Tryptophan hydroxylase-2 (TPH2) catalyzes the synthesis of neuronal serotonin, a major neurotransmitter involved in many brain functions and psychiatric disorders. Serotonin 68-77 tryptophan hydroxylase 2 Homo sapiens 0-24 19344641-1 2009 Tryptophan hydroxylase-2 (TPH2) catalyzes the synthesis of neuronal serotonin, a major neurotransmitter involved in many brain functions and psychiatric disorders. Serotonin 68-77 tryptophan hydroxylase 2 Homo sapiens 26-30 16023217-2 2006 In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on the availability of tryptophan and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO). Serotonin 101-110 tryptophan 2,3-dioxygenase Homo sapiens 271-297 16023217-2 2006 In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on the availability of tryptophan and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO). Serotonin 101-110 tryptophan 2,3-dioxygenase Homo sapiens 299-302 16475958-4 2006 In this article we review data that describe the role of serotonin in regulating dopamine release, via 5HT2C and 5HT3 receptors. Serotonin 57-66 5-hydroxytryptamine receptor 2C Homo sapiens 103-108 16436194-1 2006 Tryptophan hydroxylase isoform 2 (TPH2) is a rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and is predominantly localized in the brain. Serotonin 89-98 tryptophan hydroxylase 2 Homo sapiens 0-32 16436194-1 2006 Tryptophan hydroxylase isoform 2 (TPH2) is a rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and is predominantly localized in the brain. Serotonin 89-98 tryptophan hydroxylase 2 Homo sapiens 34-38 19225146-7 2009 When animals were pretreated with the antiemetic palonosetron, a long-term serotonin type 3 (5-HT(3)) receptor antagonist, cisplatin-induced Fos expression was significantly attenuated in the NTS, DMN, and CeA at 6 h but not at 48 h. These results indicate that cisplatin activates a neural system that includes the dorsal vagal complex and forebrain in the musk shrew, which is partially suppressed by a 5-HT(3) receptor antagonist. Serotonin 75-84 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 141-144 1401336-6 1992 Compared with the effects of acetylcholine, serotonin and histamine, eel atrial natriuretic peptide was the most potent inhibitor, with 100% inhibition at 10(-7) M; 50% inhibition was obtained at 10(-2) M in acetylcholine, and 30% inhibition in serotonin (10(-5) M) and histamine (10(-3) M). Serotonin 245-254 natriuretic peptide A Rattus norvegicus 73-99 1348566-2 1992 Out of the established endocrine cell types only insulin (B-) cells contained immunoreactivity for serotonin and noradrenaline. Serotonin 99-108 insulin Cavia porcellus 49-56 19323847-4 2009 Compared with wild-type littermates, Tdo(-/-) mice showed increased plasma levels of Trp and its metabolites 5-hydroxyindoleacetic acid (5-HIAA) and kynurenine, as well as increased levels of Trp, 5-HT and 5-HIAA in the hippocampus and midbrain. Serotonin 197-201 tryptophan 2,3-dioxygenase Mus musculus 37-40 16360124-6 2006 These results suggest that the desensitization of 5-HT2A receptor function occurs in the same way as that of 5-HT2C receptor function through chronic treatment with either fluvoxamine or paroxetine as a consequence of prolonged exposure to elevated levels of serotonin. Serotonin 259-268 5-hydroxytryptamine receptor 2C Rattus norvegicus 109-115 1615133-4 1992 These studies indicate that acute release of serotonin evoked by these releasing agents has inhibitory effects on sexual sexual drive, capacity to achieve erection and threshold for ejaculation, and these effects are mediated by either the 5-HT1c or 5-HT2 receptor. Serotonin 45-54 5-hydroxytryptamine receptor 2C Rattus norvegicus 240-246 16378243-2 2006 Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. Serotonin 84-93 tryptophan hydroxylase 2 Homo sapiens 0-24 16378243-2 2006 Tryptophan hydroxylase-2 (TPH2) is the neuronal-specific enzyme that controls brain serotonin synthesis. Serotonin 84-93 tryptophan hydroxylase 2 Homo sapiens 26-30 16378243-3 2006 There is growing genetic evidence for the possible involvement of TPH2 in serotonin-related neuropsychiatric disorders; however, the degree of genetic variation in TPH2 and, in particular, its possible functional consequences remain unknown. Serotonin 74-83 tryptophan hydroxylase 2 Homo sapiens 66-70 19383422-0 2009 Decreased immobility in swimming test by homologous interferon-alpha in mice accompanied with increased cerebral tryptophan level and serotonin turnover. Serotonin 134-143 interferon alpha Mus musculus 52-68 19383422-8 2009 Interestingly, neurochemical analysis revealed significantly increased concentrations of tryptophan and 5-hydroxyindoleacetic acid (5-HIAA)/serotonin (5-HT) ratios following IFN-alpha treatment in selected brain regions. Serotonin 140-149 interferon alpha Mus musculus 174-183 1810605-0 1991 Potentiation by endothelin-1 of 5-hydroxytryptamine-induced contraction in coronary artery of the pig. Serotonin 32-51 endothelin-1 Sus scrofa 16-28 19132526-3 2009 The novel brain-specific serotonin synthesizing enzyme, tryptophan hydroxylase 2 (TPH2), which represents the rate-limiting enzyme of serotonin production in the brain, may therefore be of particular importance in PD. Serotonin 25-34 tryptophan hydroxylase 2 Homo sapiens 56-80 16863269-19 2006 On the other hand, stimulation of the GAL2 receptor at the raphe level by local application of the GAL2 receptor agonist galanin (2-11) has been shown to increase serotonin levels in the hippocampus and dorsal raphe. Serotonin 163-172 galectin 2 Homo sapiens 38-42 16863269-19 2006 On the other hand, stimulation of the GAL2 receptor at the raphe level by local application of the GAL2 receptor agonist galanin (2-11) has been shown to increase serotonin levels in the hippocampus and dorsal raphe. Serotonin 163-172 galectin 2 Homo sapiens 99-103 16848216-1 2005 We studied the effect of immunization with a serotonin-bovine serum albumin conjugate on parameters of stress reaction to immobilization stress in rats. Serotonin 45-54 albumin Rattus norvegicus 62-75 16848216-4 2005 Active immunization of rats with a serotonin-bovine serum albumin conjugate was accompanied by production of autoantibodies against serotonin and dopamine. Serotonin 35-44 albumin Rattus norvegicus 52-65 19132526-3 2009 The novel brain-specific serotonin synthesizing enzyme, tryptophan hydroxylase 2 (TPH2), which represents the rate-limiting enzyme of serotonin production in the brain, may therefore be of particular importance in PD. Serotonin 25-34 tryptophan hydroxylase 2 Homo sapiens 82-86 16848216-4 2005 Active immunization of rats with a serotonin-bovine serum albumin conjugate was accompanied by production of autoantibodies against serotonin and dopamine. Serotonin 132-141 albumin Rattus norvegicus 52-65 1776132-0 1991 Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Serotonin 24-33 5-hydroxytryptamine receptor 2C Rattus norvegicus 106-112 16848216-5 2005 The role of autoantibodies against dopamine in modulation of the effect of immunization with serotonin-bovine serum albumin conjugate on the stress reaction in rats is discussed. Serotonin 93-102 albumin Rattus norvegicus 110-123 19228979-4 2009 Examination of the Venus expression revealed that, in the raphe nuclei, about one-half of tryptophan hydroxylase-immunoreactive neurons were positive for Venus, suggesting a potential role for oxytocin in the modulation of serotonin release. Serotonin 223-232 oxytocin Mus musculus 193-201 19228979-5 2009 Oxytocin infusion facilitated serotonin release within the median raphe nucleus and reduced anxiety-related behavior. Serotonin 30-39 oxytocin Mus musculus 0-8 19228979-7 2009 This is the first demonstration that oxytocin may regulate serotonin release and exert anxiolytic effects via direct activation of oxytocin receptor expressed in serotonergic neurons of the raphe nuclei. Serotonin 59-68 oxytocin Mus musculus 37-45 1895098-5 1991 The present study was undertaken to elucidate the possible role of NAT1 or NAT2 in serotonin acetylation in the pineal gland. Serotonin 83-92 arylamine N-acetyltransferase 2 Oryctolagus cuniculus 75-79 16237719-10 2005 In the striatum of male AQP4-knockout mice, the levels of dopamine and serotonin were remarkably increased, which was not found in female mice. Serotonin 71-80 aquaporin 4 Mus musculus 24-28 16237719-11 2005 In the hypothalamus of AQP4-knockout mice, only the serotonin level was altered. Serotonin 52-61 aquaporin 4 Mus musculus 23-27 16152573-1 2005 Brain-derived neurotrophic factor (BDNF) influences dopamine and serotonin neurotransmission in the brain, both of which are involved in the reward system of addiction. Serotonin 65-74 brain derived neurotrophic factor Homo sapiens 0-33 19004821-8 2009 In addition, Ca(v)2.2(-/-) mice showed an increase of serotonin in the hypothalamus. Serotonin 54-63 calcium channel, voltage-dependent, N type, alpha 1B subunit Mus musculus 13-21 18601957-0 2008 Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. Serotonin 11-20 brain-derived neurotrophic factor Rattus norvegicus 60-64 1759390-6 1991 After selective inhibition of MAO-A by chlorgyline the order of MAO-B-dependent effects of biogenic amines on mitochondrial enzymes studied was as follows: tyramine greater than or equal to 2-phenylethylamine much greater than serotonin. Serotonin 227-236 monoamine oxidase B Homo sapiens 64-69 16152573-1 2005 Brain-derived neurotrophic factor (BDNF) influences dopamine and serotonin neurotransmission in the brain, both of which are involved in the reward system of addiction. Serotonin 65-74 brain derived neurotrophic factor Homo sapiens 35-39 1872891-3 1991 The 1,4-diamines putrescine, spermidine, spermine, agmatine, histamine, serotonin, tryptamine, chlorpheniramine and harmaline at 55 microM strongly suppressed ODC induction by 0.5 mM ornithine in perifused Ehrlich ascites cells. Serotonin 72-81 ornithine decarboxylase, structural 1 Mus musculus 159-162 18930035-3 2008 We showed that, among these neuromodulators, serotonin acting via the 5-HT2B receptor, is involved in the control of retinoblasts proliferation and survival in Xenopus embryogenesis. Serotonin 45-54 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled L homeolog Xenopus laevis 70-76 18930035-6 2008 The in vivo experiments revealed that an over serotonin signaling, via 5-HT2B receptors, resulted in the formation of eyes with an irregular form, position and orientation. Serotonin 46-55 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled L homeolog Xenopus laevis 71-77 1658963-3 1991 TFC-612 also inhibited thrombin induced (14C) serotonin release in rabbit platelets. Serotonin 46-55 prothrombin Oryctolagus cuniculus 23-31 18604533-1 2008 PURPOSE: Pretreatment with cyclosporine, a P-glycoprotein (P-gp) modulator increases brain uptake of 4-(2"-methoxyphenyl)-1-[2"-(N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethylpiperazine ([(18)F]MPPF) for binding to hydroxytryptamine(1A) (5-HT(1A)) receptors. Serotonin 215-232 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 43-57 18604533-1 2008 PURPOSE: Pretreatment with cyclosporine, a P-glycoprotein (P-gp) modulator increases brain uptake of 4-(2"-methoxyphenyl)-1-[2"-(N-2"-pyridinyl)-p-[(18)F]fluorobenzamido]ethylpiperazine ([(18)F]MPPF) for binding to hydroxytryptamine(1A) (5-HT(1A)) receptors. Serotonin 215-232 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 59-63 1828363-2 1991 Here, we show that platelet activation following addition of a monoclonal antibody directed against GPIIb/IIIa, P256 is completely blocked by IV-3, as monitored by serotonin release, calcium and pH modifications. Serotonin 164-173 integrin subunit alpha 2b Homo sapiens 100-105 18693086-7 2008 When compared to controls, there was a significant decrease in serotonin levels in the cerebella of offspring of virally exposed mice at P14. Serotonin 63-72 procollagen C-endopeptidase enhancer protein Mus musculus 137-140 1901210-1 1991 Peroxidase (EC 1.11.1.7)/H2O2, ceruloplasmin (human type X)/O2, and tyrosinase (EC 1.14.18.1)/O2 all oxidized the indolic neurotransmitter 5-hydroxytryptamine (5-HT) in the physiological pH domain. Serotonin 139-158 tyrosinase Homo sapiens 52-78 18784307-0 2008 Serotonin hyperinnervation abolishes seizure susceptibility in Otx2 conditional mutant mice. Serotonin 0-9 orthodenticle homeobox 2 Mus musculus 63-67 18784307-5 2008 Adult En1(cre/+); Otx2(flox/flox) mice showed increased serotonin (5-HT) levels in the pons, ventral midbrain, hippocampus (CA3 subfield), and cerebral cortex, as indicated by HPLC and immunohistochemistry. Serotonin 56-65 orthodenticle homeobox 2 Mus musculus 18-22 1829353-0 1991 Depletion of brain serotonin differently affects behaviors induced by 5HT1A, 5HT1C, and 5HT2 receptor activation in rats. Serotonin 19-28 5-hydroxytryptamine receptor 2C Rattus norvegicus 77-82 1829353-1 1991 5-hydroxytryptamine (5HT)-depleted rats were subjected to behavioral experiments in which the response to activation of 5HT1A, 5HT1c, and 5HT2 receptor subtypes was measured. Serotonin 0-19 5-hydroxytryptamine receptor 2C Rattus norvegicus 127-132 18782386-2 2008 Tryptophan hydroxylase (TPH2) plays an important role in serotonergic neurotransmission by serving as the rate-limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. Serotonin 131-140 tryptophan hydroxylase 2 Homo sapiens 24-28 1829353-4 1991 The dose-response curve for penile erections, a 5HT1c receptor-mediated response after mCPP (0.1-1.0 mg/kg), a direct 5HT1c agonist, is shifted to the left after 5HT depletion, whereas the response to indirect activation of the 5HT1c receptor with the 5HT reuptake inhibitors citalopram (2.2-4.6 mg/kg) and paroxetine (0.22-2.2 mg/kg) was inhibited after 5HT depletion. Serotonin 48-51 5-hydroxytryptamine receptor 2C Rattus norvegicus 118-123 1829353-4 1991 The dose-response curve for penile erections, a 5HT1c receptor-mediated response after mCPP (0.1-1.0 mg/kg), a direct 5HT1c agonist, is shifted to the left after 5HT depletion, whereas the response to indirect activation of the 5HT1c receptor with the 5HT reuptake inhibitors citalopram (2.2-4.6 mg/kg) and paroxetine (0.22-2.2 mg/kg) was inhibited after 5HT depletion. Serotonin 48-51 5-hydroxytryptamine receptor 2C Rattus norvegicus 118-123 1829353-4 1991 The dose-response curve for penile erections, a 5HT1c receptor-mediated response after mCPP (0.1-1.0 mg/kg), a direct 5HT1c agonist, is shifted to the left after 5HT depletion, whereas the response to indirect activation of the 5HT1c receptor with the 5HT reuptake inhibitors citalopram (2.2-4.6 mg/kg) and paroxetine (0.22-2.2 mg/kg) was inhibited after 5HT depletion. Serotonin 118-121 5-hydroxytryptamine receptor 2C Rattus norvegicus 48-53 18599541-7 2008 5-Hydroxytryptamine increased Src kinase activity and PP2-sensitive tyrosine-phosphorylated proteins. Serotonin 0-19 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 30-33 1829353-4 1991 The dose-response curve for penile erections, a 5HT1c receptor-mediated response after mCPP (0.1-1.0 mg/kg), a direct 5HT1c agonist, is shifted to the left after 5HT depletion, whereas the response to indirect activation of the 5HT1c receptor with the 5HT reuptake inhibitors citalopram (2.2-4.6 mg/kg) and paroxetine (0.22-2.2 mg/kg) was inhibited after 5HT depletion. Serotonin 118-121 5-hydroxytryptamine receptor 2C Rattus norvegicus 48-53 1987274-3 1991 Released serotonin locally recruits and activates CD4+ Th-1 classical DTH effector T cells that secrete lymphokines that attract and activate a nonspecific perivascular infiltrate of circulating, bone marrow-derived leukocytes. Serotonin 9-18 CD4 antigen Mus musculus 50-53 18774444-7 2008 In this article, the mechanism of action of MAO-B inhibitors, their potential neuroprotective effects, interactions such as the cheese reaction, and serotonin syndrome are discussed. Serotonin 149-158 monoamine oxidase B Homo sapiens 44-49 1913239-0 1991 [Synthesis and pharmacological study of radioiodinated serotonin derivative specific of 5-HT1B and 5-HT1D binding sites of the central nervous system]. Serotonin 55-64 5-hydroxytryptamine receptor 1B Rattus norvegicus 88-94 18657242-2 2008 Several family and population-based studies have reported associations between the BDNF gene and serotonin-related genes, specifically the serotonin transporter (5HTT) gene, with bipolar disorder (BD) and SB. Serotonin 97-106 brain derived neurotrophic factor Homo sapiens 83-87 1834089-8 1991 All data further support the idea that endogenous serotonin acts via the stimulation of 5-HT1B receptors to induce its inhibitory effects on masculine sexual behaviour. Serotonin 50-59 5-hydroxytryptamine receptor 1B Rattus norvegicus 88-94 18680475-8 2008 The present review also makes a comment on the role of arylalkylamine N-acetyltransferase, an important enzyme involved in the conversion of serotonin to melatonin, in asthma pathogenesis. Serotonin 141-150 aralkylamine N-acetyltransferase Homo sapiens 55-89 2213008-0 1990 Physicochemical properties of serotonin 5-HT3 binding sites solubilized from membranes of NG 108-15 neuroblastoma-glioma cells. Serotonin 30-39 hypothermia due to alcohol sensitivity 3 Mus musculus 42-45 18385101-5 2008 Here we show that Mbd1 mutant (Mbd1(-/-)) mice exhibit several core deficits frequently associated with autism, including reduced social interaction, learning deficits, anxiety, defective sensory motor gating, depression and abnormal brain serotonin activity. Serotonin 240-249 methyl-CpG binding domain protein 1 Mus musculus 18-22 18385101-5 2008 Here we show that Mbd1 mutant (Mbd1(-/-)) mice exhibit several core deficits frequently associated with autism, including reduced social interaction, learning deficits, anxiety, defective sensory motor gating, depression and abnormal brain serotonin activity. Serotonin 240-249 methyl-CpG binding domain protein 1 Mus musculus 31-35 2389798-9 1990 The low blood serotonin and tryptophan levels in TS are consistent with the wide range of behavioral disorders seen in TS and suggest tryptophan oxygenase as a possible candidate gene. Serotonin 14-23 tryptophan 2,3-dioxygenase Homo sapiens 134-154 18543980-3 2008 Here, we built structural models of human transporters of dopamine, norepinephrine, and serotonin using the LeuT structure. Serotonin 88-97 Leucine transport, high Homo sapiens 108-112 18400843-10 2008 Serotonin itself is bound to Rac1 by TGase following 5-HT(2A) receptor stimulation as demonstrated by coimmunoprecipitation experiments and a dose-dependent decrease of serotonin-associated Rac1 by cystamine. Serotonin 0-9 Rac family small GTPase 1 Homo sapiens 190-194 2121313-3 1990 In humans, depression was shown to be accompanied by increases in plasma cortisol, inability to decrease cortisol in the dexamethasone suppression test and increases in plasma alpha-1 acid glycoprotein (AGP), an endogenous modulator for the serotonin uptake site. Serotonin 241-250 orosomucoid 1 Rattus norvegicus 203-206 18400843-10 2008 Serotonin itself is bound to Rac1 by TGase following 5-HT(2A) receptor stimulation as demonstrated by coimmunoprecipitation experiments and a dose-dependent decrease of serotonin-associated Rac1 by cystamine. Serotonin 169-178 Rac family small GTPase 1 Homo sapiens 29-33 18400843-10 2008 Serotonin itself is bound to Rac1 by TGase following 5-HT(2A) receptor stimulation as demonstrated by coimmunoprecipitation experiments and a dose-dependent decrease of serotonin-associated Rac1 by cystamine. Serotonin 169-178 Rac family small GTPase 1 Homo sapiens 190-194 18400843-11 2008 These data support the hypothesis that Rac1 activity is transiently increased due to TGase-catalyzed transamidation of serotonin to Rac1 via stimulation of 5-HT(2A) receptors. Serotonin 119-128 Rac family small GTPase 1 Homo sapiens 39-43 18400843-11 2008 These data support the hypothesis that Rac1 activity is transiently increased due to TGase-catalyzed transamidation of serotonin to Rac1 via stimulation of 5-HT(2A) receptors. Serotonin 119-128 Rac family small GTPase 1 Homo sapiens 132-136 1697219-2 1990 Responses of both types of SPN to iontophoretic application of serotonin were characterized by an increase in the rate of discharge that was slow in onset (mean +/- SD = 36 +/- 21 s) and prolonged in afterdischarge (115 +/- 70 s) following termination of application. Serotonin 63-72 DEAF1 transcription factor Homo sapiens 27-30 1981686-0 1990 Activation by serotonin of starfish eggs expressing the rat serotonin 1c receptor. Serotonin 14-23 5-hydroxytryptamine receptor 2C Rattus norvegicus 60-81 2340447-0 1990 Serotonin agonist and antagonist actions in hippocampal CA1 neurons. Serotonin 0-9 carbonic anhydrase 1 Homo sapiens 56-59 16206279-6 2005 Immunohistochemical localization of serotonin revealed a fourfold increase in the density of serotonergic fibers surrounding the injection sites of Adv.BDNF and Adv.NT-3, corresponding to a 50% increase in cortical serotonin concentration, compared with a control vector containing the cDNA for enhanced green fluorescent protein (Adv.EGFP). Serotonin 36-45 brain-derived neurotrophic factor Rattus norvegicus 152-156 16206279-6 2005 Immunohistochemical localization of serotonin revealed a fourfold increase in the density of serotonergic fibers surrounding the injection sites of Adv.BDNF and Adv.NT-3, corresponding to a 50% increase in cortical serotonin concentration, compared with a control vector containing the cDNA for enhanced green fluorescent protein (Adv.EGFP). Serotonin 215-224 brain-derived neurotrophic factor Rattus norvegicus 152-156 2340447-1 1990 The actions of serotonin (5-HT) and its putative agonists and antagonists were examined in vitro on hippocampal CA1 neurons using intracellular recordings, demonstrating that the cellular pharmacological effects can not necessarily be predicted from binding characteristics alone. Serotonin 15-24 carbonic anhydrase 1 Homo sapiens 112-115 2138518-1 1990 Serotonin (10(-4) - 10(-7) M) augmented natural killer cell cytotoxicity (NKCC) of human CD16+/non-T lymphocytes in vitro against the NK-sensitive target cells K 562 erythroleukemic, Molt-4 lymphoma, Chang liver cells, and against EBV-transformed Daudi B-lymphoblastoid target cells by a mechanism of action involving a prostaglandin-and IL-1-independent accessory function of monocytes. Serotonin 0-9 Fc gamma receptor IIIa Homo sapiens 89-93 16044172-1 2005 Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. Serotonin 181-190 tryptophan hydroxylase 2 Homo sapiens 105-109 2308260-2 1990 PAF content was assessed following extraction, isolation and quantification of this alkyl ether lipid using a bioassay based on [3H]-serotonin release from labelled rabbit platelets. Serotonin 133-142 PCNA clamp associated factor Rattus norvegicus 0-3 15955429-2 2005 Serotonin (5-HT), an anorectic monoamine acts primarily via 5-HT 1B-receptors in hypothalamic nuclei while neuropeptide Y (NPY) acts an orexigenic peptide. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 60-67 2329057-0 1990 Secretin-cells of the mammalian intestine contain serotonin. Serotonin 50-59 secretin Homo sapiens 0-8 15927553-1 2005 In cancer anorexia, a decrease in food intake (FI) occurs concomitant with changes in orexigenic peptides such as neuropeptide Y (NPY) and anorexigenic peptides such as alpha-melanocyte-stimulating hormone (alpha-MSH) and anorexigenic neurotransmitter serotonin. Serotonin 252-261 proopiomelanocortin Rattus norvegicus 169-205 15853814-4 2005 Serotonin stimulation of HEK293 cells transiently expressing Gs-coupled 5-HT7 receptors induced protein kinase A-dependent phosphorylation of the endogenous human Ras-GRF1 on Ser927 and of transfected mouse Ras-GRF1 on Ser916. Serotonin 0-9 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 163-171 15853814-4 2005 Serotonin stimulation of HEK293 cells transiently expressing Gs-coupled 5-HT7 receptors induced protein kinase A-dependent phosphorylation of the endogenous human Ras-GRF1 on Ser927 and of transfected mouse Ras-GRF1 on Ser916. Serotonin 0-9 RAS protein-specific guanine nucleotide-releasing factor 1 Mus musculus 207-215 15853814-5 2005 Ras-GRF1 overexpression increased basal and serotonin-stimulated ERK1/2 phosphorylation. Serotonin 44-53 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 0-8 15853814-7 2005 However, the deletion of amino acids 1-225, including the Ca2+/calmodulin-binding IQ domain, from Ras-GRF1 reduced both basal and serotonin-stimulated ERK1/2 phosphorylation. Serotonin 130-139 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 98-106 2222781-3 1990 In view of the part that MAO B plays in metabolizing serotonin (5HT) and of the relationship which exists between 3H-IMI binding and 5HT uptake, our results would suggest that with AD there occurs a complex dysfunction in the 5HT system, at least at a peripheral level. Serotonin 53-62 monoamine oxidase B Homo sapiens 25-30 15857682-1 2005 Recently, a second gene that codes for the rate-limiting enzyme in serotonin synthesis was found in brain, named tryptophan hydroxylase-2 (TPH-2). Serotonin 67-76 tryptophan hydroxylase 2 Homo sapiens 113-137 15857682-1 2005 Recently, a second gene that codes for the rate-limiting enzyme in serotonin synthesis was found in brain, named tryptophan hydroxylase-2 (TPH-2). Serotonin 67-76 tryptophan hydroxylase 2 Homo sapiens 139-144 15857682-8 2005 In conclusion, ovarian steroids stimulate TPH-2 mRNA expression, which could in turn cause an increase in serotonin synthesis. Serotonin 106-115 tryptophan hydroxylase 2 Homo sapiens 42-47 2222781-3 1990 In view of the part that MAO B plays in metabolizing serotonin (5HT) and of the relationship which exists between 3H-IMI binding and 5HT uptake, our results would suggest that with AD there occurs a complex dysfunction in the 5HT system, at least at a peripheral level. Serotonin 64-67 monoamine oxidase B Homo sapiens 25-30 15722186-7 2005 We have earlier shown that AP-2beta genotype is associated with serotonergic phenotypes and that brainstem levels of AP-2beta correlate positively to serotonin metabolism in rat frontal cortex. Serotonin 150-159 transcription factor AP-2 beta Homo sapiens 117-125 2141111-7 1990 In contrast, application of high concentrations of alpha-methyl-5-hydroxytryptamine, a serotonin analog which activates 5-HT1C and 5-HT2 receptor subtypes, depolarized motoneurons. Serotonin 87-96 5-hydroxytryptamine receptor 2C Homo sapiens 120-126 2141111-8 1990 These depolarizations, and those produced by high concentrations of serotonin, were blocked by the 5-HT1C/5-HT2 antagonists ketanserin, methysergide and mianserin. Serotonin 68-77 5-hydroxytryptamine receptor 2C Homo sapiens 99-105 33794383-0 2021 Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration. Serotonin 0-9 NADPH oxidase 4 Rattus norvegicus 64-79 15629698-2 2005 Here, we identify a (G1463A) single nucleotide polymorphism (SNP) in the rate-limiting enzyme of neuronal serotonin synthesis, human tryptophan hydroxylase-2 (hTPH2). Serotonin 106-115 tryptophan hydroxylase 2 Homo sapiens 133-157 15629698-2 2005 Here, we identify a (G1463A) single nucleotide polymorphism (SNP) in the rate-limiting enzyme of neuronal serotonin synthesis, human tryptophan hydroxylase-2 (hTPH2). Serotonin 106-115 tryptophan hydroxylase 2 Homo sapiens 159-164 34906639-1 2022 BACKGROUND: Pharmacological studies have yielded valuable insights into the role of the serotonin 4 receptor (HTR4) in major depressive episodes (MDE) and response to antidepressant drugs (AD). Serotonin 88-97 5-hydroxytryptamine receptor 4 Homo sapiens 110-114 15629698-3 2005 The functional SNP in hTPH2 replaces the highly conserved Arg441 with His, which results in approximately 80% loss of function in serotonin production when hTPH2 is expressed in PC12 cells. Serotonin 130-139 tryptophan hydroxylase 2 Homo sapiens 22-27 15629698-3 2005 The functional SNP in hTPH2 replaces the highly conserved Arg441 with His, which results in approximately 80% loss of function in serotonin production when hTPH2 is expressed in PC12 cells. Serotonin 130-139 tryptophan hydroxylase 2 Homo sapiens 156-161 15629698-6 2005 Identification of a loss-of-function mutation in hTPH2 suggests that defect in brain serotonin synthesis may represent an important risk factor for unipolar major depression. Serotonin 85-94 tryptophan hydroxylase 2 Homo sapiens 49-54 15634783-3 2005 Here, we show that a new target for cAMP, exchange protein activated by cAMP (Epac) or cAMP-regulated guanine nucleotide exchange protein, is involved in the hormonal enhancement of synaptic transmission by serotonin. Serotonin 207-216 Rap guanine nucleotide exchange factor 3 Homo sapiens 42-76 15634783-3 2005 Here, we show that a new target for cAMP, exchange protein activated by cAMP (Epac) or cAMP-regulated guanine nucleotide exchange protein, is involved in the hormonal enhancement of synaptic transmission by serotonin. Serotonin 207-216 Rap guanine nucleotide exchange factor 3 Homo sapiens 78-82 34780807-9 2022 In summary, the aging process and TPH2 deficit affect the CYP2D activity and protein level in female rats, which may have a negative impact on the compensatory capacity of CYP2D in the synthesis of serotonin and dopamine in cerebral structures involved in cognitive and emotional functions. Serotonin 198-207 tryptophan hydroxylase 2 Rattus norvegicus 34-38 15466248-0 2005 Up-regulation of P-glycoprotein expression in small intestine under chronic serotonin-depleted conditions in rats. Serotonin 76-85 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 17-31 34649926-2 2021 We previously found that mouse insulin gene (Ins2) isoforms are expressed in brain choroid plexus (ChP) epithelium cells where insulin secretion is regulated by serotonin and not by glucose. Serotonin 161-170 insulin II Mus musculus 45-49 15466248-1 2005 To investigate the role of serotonin (5-HT), an important neurotransmitter and hormone/paracrine agent in the small intestine, in the transport activity of P-glycoprotein (P-gp), the intestinal transport of quinidine, a P-gp substrate, was examined in 5-HT-depleted rats prepared by intraperitoneal administration of p-chlorophenylalanine, a specific inhibitor of tryptophan hydroxylase in 5-HT biosynthesis. Serotonin 27-36 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 156-170 15466248-1 2005 To investigate the role of serotonin (5-HT), an important neurotransmitter and hormone/paracrine agent in the small intestine, in the transport activity of P-glycoprotein (P-gp), the intestinal transport of quinidine, a P-gp substrate, was examined in 5-HT-depleted rats prepared by intraperitoneal administration of p-chlorophenylalanine, a specific inhibitor of tryptophan hydroxylase in 5-HT biosynthesis. Serotonin 27-36 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 172-176 15466248-1 2005 To investigate the role of serotonin (5-HT), an important neurotransmitter and hormone/paracrine agent in the small intestine, in the transport activity of P-glycoprotein (P-gp), the intestinal transport of quinidine, a P-gp substrate, was examined in 5-HT-depleted rats prepared by intraperitoneal administration of p-chlorophenylalanine, a specific inhibitor of tryptophan hydroxylase in 5-HT biosynthesis. Serotonin 27-36 ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus 220-224 34759890-0 2021 PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization. Serotonin 31-40 adenylate cyclase activating polypeptide 1 receptor 1 Mus musculus 6-10 16084651-4 2005 Indeed, systemic as well as local administrations of the serotonin agonist quipazine in the region of the suprachiasmatic nucleus mimic the effects of light on the circadian system of rats, i.e. they induce phase-advances of the locomotor activity rhythm as well as c-FOS expression in the suprachiasmatic nucleus during late subjective night. Serotonin 57-66 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 268-271 15730876-7 2005 Pharmacological tests with serotonin receptor antagonists and agonists reveal that 5HT action on juxtaglomerular cells would be mainly mediated by 5HT2C receptors. Serotonin 83-86 5-hydroxytryptamine receptor 2C Rattus norvegicus 147-152 15730876-11 2005 The involved GABAergic neurons are hypothesized to be juxtaglomerular and granular cells, on which serotonin would act mainly via 5HT2C and via 5HT2A receptors respectively. Serotonin 99-108 5-hydroxytryptamine receptor 2C Rattus norvegicus 130-135 34759890-1 2021 Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Serotonin 169-178 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 199-205 34759890-1 2021 Mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP) display psychomotor abnormalities, most of which are ameliorated by atypical antipsychotics with serotonin (5-HT) 2A receptor (5-HT2A) antagonism. Serotonin 180-184 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 199-205 34771469-7 2021 Overall, the results revealed that long-term exposure to 5-HT upregulated EZH2, and the noncanonical action of EZH2 allowed the expression of TPH1-5-HT7 axis leading to gemcitabine resistance and CSC population in PDAC. Serotonin 57-61 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 74-78 15126246-3 2004 Our results indicate that ANP(1-28), CNP(1-22), and C-ANF inhibit cAMP synthesis directly stimulated by forskolin or by the physiological agonists histamine and 5-hydroxytryptamine. Serotonin 161-180 natriuretic peptide C Rattus norvegicus 37-40 34909684-8 2021 Key findings: Drug treatment substantially reduced 5-HT- and ATP-evoked intracellular Ca2+ release and TLR4 expression compared to those in untreated chondrocytes. Serotonin 51-55 toll like receptor 4 Equus caballus 103-107 15595639-6 2004 Bombesin and VIP appeared to be located in enterochromaffin-like (ECL) endocrine cells primarily responsible for the production of serotonin. Serotonin 131-140 gastrin releasing peptide Homo sapiens 0-8 18607747-4 2008 The different behavioral effects of administration of neurotensin corresponded to identifiable changes in the levels of serotonin and its metabolite 5-hydroxyindoleacetic acid in the caudate nuclei of the brain. Serotonin 120-129 neurotensin Rattus norvegicus 54-65 18362150-1 2008 Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Serotonin 74-83 aralkylamine N-acetyltransferase Homo sapiens 0-34 34388373-4 2021 Intriguingly, we also find that a novel serotonin-gated cation channel, LGC-50, is essential for aversive olfactory learning of pathogenic bacteria, a process known to depend on serotonergic neurotransmission. Serotonin 40-49 Ligand-gated ion channel 50 Caenorhabditis elegans 72-78 18362150-1 2008 Arylalkylamine N-acetyltransferase (AANAT) catalyzes the N-acetylation of serotonin, the penultimate step in the synthesis of melatonin. Serotonin 74-83 aralkylamine N-acetyltransferase Homo sapiens 36-41 15308297-2 2004 Several studies have suggested that dopamine (DA) uptake into serotonin (5-HT) terminals by the 5-HT reuptake transporter (SERT) and subsequent deamination by monoamine oxidase-B (MAO-B) leads to the formation of hydrogen peroxide and may be major contributors to this serotonergic toxicity. Serotonin 62-71 monoamine oxidase B Homo sapiens 180-185 34625528-1 2021 Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Serotonin 69-78 tryptophan hydroxylase 2 Homo sapiens 0-29 15272612-8 2004 These findings suggest that secretin promotes the metabolism of serotonin and dopamine in the central nervous system, which may contribute to improvement in clinical symptoms of autism. Serotonin 64-73 secretin Homo sapiens 28-36 18387300-1 2008 SAR for dual serotonin & noradrenaline reuptake inhibition. Serotonin 13-22 sarcosine dehydrogenase Homo sapiens 0-3 34625528-1 2021 Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Serotonin 69-78 tryptophan hydroxylase 2 Homo sapiens 31-35 18211820-5 2008 Consistent results of the upstream regulatory element search and the co-localization search of these genes indicated that the regulation may be executed by Pax5, Pax7 and Gata3, known to be involved in the survival, proliferation, and migration of serotonergic neurons in the developing brain, and these factors are supposed to keep functioning to regulate downstream genes related to serotonin system in the adult brain. Serotonin 385-394 paired box 7 Mus musculus 162-166 34625528-1 2021 Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Serotonin 80-84 tryptophan hydroxylase 2 Homo sapiens 0-29 34625528-1 2021 Tryptophan hydroxylase type 2 (Tph2) is the rate-limiting enzyme for serotonin (5-HT) biosynthesis in the brain. Serotonin 80-84 tryptophan hydroxylase 2 Homo sapiens 31-35 15075741-11 2004 This scenario may occur in carcinoid valve disease because serotonin can induce interstitial cell expression of tumor growth factor beta1. Serotonin 59-68 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens 132-137 34625528-2 2021 Dysfunctional Tph2 alters 5-HT biosynthesis, leading to a deficiency of 5-HT, which could have repercussions on human behavior. Serotonin 26-30 tryptophan hydroxylase 2 Homo sapiens 14-18 34625528-2 2021 Dysfunctional Tph2 alters 5-HT biosynthesis, leading to a deficiency of 5-HT, which could have repercussions on human behavior. Serotonin 72-76 tryptophan hydroxylase 2 Homo sapiens 14-18 14755447-2 2004 Tryptophan 2,3 dioxygenase (TDO2) is the rate-limiting enzyme in the catabolism of tryptophan, the precursor of serotonin. Serotonin 112-121 tryptophan 2,3-dioxygenase Homo sapiens 0-26 18219447-4 2008 In the present study, to evaluate BDNF expression in differentiated glial cells, the glioma cells were pretreated with progesterone, and the effect of serotonin on BDNF messenger RNA levels in these cells was examined. Serotonin 151-160 brain-derived neurotrophic factor Rattus norvegicus 164-168 34684446-12 2021 In conclusion, the results of this study suggest that Klamin exerts spasmolytic effects in human colon contractility through beta-PEA, that, by activating neural TAAR1, induce serotonin release from serotoninergic neurons of the myenteric plexus. Serotonin 177-186 trace amine associated receptor 1 Homo sapiens 163-168 18219447-5 2008 Progesterone pretreatment enhanced the stimulatory action of serotonin on BDNF gene expression, and the enhancement of serotonin action observed in the cells pretreated with progesterone was almost completely abolished by finasteride, an inhibitor of the enzyme involved in the production of 5alpha-reduced neurosteroids. Serotonin 61-70 brain-derived neurotrophic factor Rattus norvegicus 74-78 18219447-6 2008 These findings propose the possibility that neurosteroid-mediated glial cell differentiation may result in the enhancement of serotonin-stimulated BDNF gene expression, which is considered to contribute to the survival, regeneration, and plasticity of neuronal cells in the brain, and hence, leading to the improvement of mood disorders and other symptoms in depressive patients. Serotonin 126-135 brain derived neurotrophic factor Homo sapiens 147-151 14755447-2 2004 Tryptophan 2,3 dioxygenase (TDO2) is the rate-limiting enzyme in the catabolism of tryptophan, the precursor of serotonin. Serotonin 112-121 tryptophan 2,3-dioxygenase Homo sapiens 28-32 14755447-3 2004 A mutation that results in decreased activity of the TDO2 can decrease catabolism of tryptophan and increase the level of whole body serotonin. Serotonin 133-142 tryptophan 2,3-dioxygenase Homo sapiens 53-57 14571255-6 2004 The 5-HT(6)/ChAT ratio was related to aggression both in the frontal and temporal cortex. Serotonin 4-8 choline O-acetyltransferase Homo sapiens 12-16 18094048-2 2008 Caenorhabditis elegans fat-3 mutants lack long-chain polyunsaturated fatty acids (LC-PUFAs); they release abnormally low levels of serotonin and acetylcholine and are depleted of synaptic vesicles, but the mechanistic basis of these defects is unclear. Serotonin 131-140 Delta(6)-fatty-acid desaturase fat-3;FA_desaturase domain-containing protein Caenorhabditis elegans 23-28 17973628-1 2008 TPH (tryptophan hydroxylase) catalyses the rate-limiting step in the synthesis of serotonin, and exists in two isoforms: TPH1, mainly found in peripheral tissues and the pineal body, and TPH2, a neuronal form. Serotonin 82-91 tryptophan hydroxylase 2 Homo sapiens 187-191 34550535-7 2022 The addition of Cr to the diet, irrespective of its form, also increased the serotonin level, which should be considered a beneficial effect. Serotonin 77-86 calbindin 2 Rattus norvegicus 16-18 17899022-1 2008 RATIONALE: It has been suggested that the increase in serotonin transmission induced by indirect agonists such as fenfluramine and fluoxetine attenuates cue-elicited reinstatement of cocaine-seeking in rats through a 5-HT2C receptor-dependent mechanism. Serotonin 54-63 5-hydroxytryptamine receptor 2C Homo sapiens 217-223 34120066-1 2021 Agomelatine (AGO) is an antidepressant drug with agonistic activity at melatonin receptor 1 (MT1) and MT2 and with neutral antagonistic activity at serotonin receptor 5-HT2C. Serotonin 148-157 5-hydroxytryptamine receptor 2C Rattus norvegicus 167-173 17908235-0 2007 Hydroxylated serotonin and dopamine as substrates and inhibitors for human cytosolic SULT1A3. Serotonin 13-22 sulfotransferase family 1A member 3 Homo sapiens 85-92 34384732-2 2021 Recent studies have suggested a close relationship between the serotonin (5-hydroxytryptamine (5-HT)) system and brain-derived neurotrophic factor (BDNF), raising the question of whether BDNF plays a role in ejaculation regulation. Serotonin 63-72 brain-derived neurotrophic factor Rattus norvegicus 113-146 17908235-10 2007 By serving as substrates for SULT1A3, these hydroxylated monoamines may interfere with the homeostasis of endogenous serotonin and dopamine. Serotonin 117-126 sulfotransferase family 1A member 3 Homo sapiens 29-36 17822443-8 2007 Inhibitors of cyclooxygenase and antibody to PGE(2) abrogated the inhibitory and stimulatory effect of serotonin on TNF and IL-10 production, respectively, whereas NO synthase inhibitor eliminated serotonin-stimulated IL-10 increase. Serotonin 103-112 interleukin 10 Homo sapiens 124-129 17822443-8 2007 Inhibitors of cyclooxygenase and antibody to PGE(2) abrogated the inhibitory and stimulatory effect of serotonin on TNF and IL-10 production, respectively, whereas NO synthase inhibitor eliminated serotonin-stimulated IL-10 increase. Serotonin 103-112 interleukin 10 Homo sapiens 218-223 34384732-2 2021 Recent studies have suggested a close relationship between the serotonin (5-hydroxytryptamine (5-HT)) system and brain-derived neurotrophic factor (BDNF), raising the question of whether BDNF plays a role in ejaculation regulation. Serotonin 63-72 brain-derived neurotrophic factor Rattus norvegicus 148-152 34384732-2 2021 Recent studies have suggested a close relationship between the serotonin (5-hydroxytryptamine (5-HT)) system and brain-derived neurotrophic factor (BDNF), raising the question of whether BDNF plays a role in ejaculation regulation. Serotonin 74-93 brain-derived neurotrophic factor Rattus norvegicus 113-146 17357148-1 2007 Polymorphic enzyme cytochrome P450 (CYP) 2C19 is expressed not only in the liver but also in the brain and mediates the biotransformation of 5-hydroxytriptamine (5-HT). Serotonin 141-160 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 19-45 34384732-2 2021 Recent studies have suggested a close relationship between the serotonin (5-hydroxytryptamine (5-HT)) system and brain-derived neurotrophic factor (BDNF), raising the question of whether BDNF plays a role in ejaculation regulation. Serotonin 74-93 brain-derived neurotrophic factor Rattus norvegicus 148-152 17357148-1 2007 Polymorphic enzyme cytochrome P450 (CYP) 2C19 is expressed not only in the liver but also in the brain and mediates the biotransformation of 5-hydroxytriptamine (5-HT). Serotonin 162-166 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 19-45 34384732-2 2021 Recent studies have suggested a close relationship between the serotonin (5-hydroxytryptamine (5-HT)) system and brain-derived neurotrophic factor (BDNF), raising the question of whether BDNF plays a role in ejaculation regulation. Serotonin 95-99 brain-derived neurotrophic factor Rattus norvegicus 113-146 34384732-2 2021 Recent studies have suggested a close relationship between the serotonin (5-hydroxytryptamine (5-HT)) system and brain-derived neurotrophic factor (BDNF), raising the question of whether BDNF plays a role in ejaculation regulation. Serotonin 95-99 brain-derived neurotrophic factor Rattus norvegicus 148-152 34384732-5 2021 AIM: The aim of this study was to investigate the interaction between BDNF and 5-HT levels in raphe nuclei which contains the serotonergic neurons in a rat animal model with different ejaculatory behavior. Serotonin 79-83 brain-derived neurotrophic factor Rattus norvegicus 70-74 34384732-8 2021 Real-Time Quantitative PCR and Western blot analyses were used to measure the mRNA level of Tryptophan Hydroxylase-2 (TPH2) gene and the expression of TPH2 protein (the rate-limiting enzyme in central 5-HT synthesis) in raphe nuclei, respectively. Serotonin 201-205 tryptophan hydroxylase 2 Rattus norvegicus 151-155 17617391-5 2007 In rat aortas, recombinant adiponectin at serum levels (2-5 microg/ml) inhibited serotonin-induced contractions. Serotonin 81-90 adiponectin, C1Q and collagen domain containing Rattus norvegicus 27-38 34384732-11 2021 There was a strong positive correlation between the levels of BDNF and 5-HT (r = 0.944, P < .001). Serotonin 71-75 brain-derived neurotrophic factor Rattus norvegicus 62-66 34384732-16 2021 CONCLUSION: BDNF may act via increasing the synthesis of central 5-HT in the process of ejaculation regulation. Serotonin 65-69 brain derived neurotrophic factor Homo sapiens 12-16 34384732-17 2021 Our results suggest lack of endogenous BDNF induces the downregulation of TPH2 gene expression and the decrease of 5-HT synthesis in raphe nuclei of rapid ejaculator rats. Serotonin 115-119 brain-derived neurotrophic factor Rattus norvegicus 39-43 34392133-7 2021 Not the selective norepinephrine reuptake inhibitor reboxetine but the selective serotonin reuptake inhibitors fluvoxamine and sertraline upregulated the PGD2-induced osteoprotegerin release, which was further amplified by morphine. Serotonin 81-90 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 167-182 17092970-2 2007 The purpose of the present study was to investigate whether the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with the antidepressant effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, and fluvoxamine, a selective serotonin reuptake inhibitor. Serotonin 199-208 brain derived neurotrophic factor Homo sapiens 90-123 17092970-2 2007 The purpose of the present study was to investigate whether the G196A polymorphism of the brain-derived neurotrophic factor (BDNF) gene is associated with the antidepressant effect of milnacipran, a serotonin norepinephrine reuptake inhibitor, and fluvoxamine, a selective serotonin reuptake inhibitor. Serotonin 199-208 brain derived neurotrophic factor Homo sapiens 125-129 34392133-11 2021 These results suggest that tramadol amplifies the PGD2-induced osteoprotegerin synthesis at the upstream of p38 MAP kinase and SAPK/JNK in the involvement of both MOR and 5-HT transporter in osteoblasts. Serotonin 171-175 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 63-78 17463043-9 2007 5HT had inhibitory effects on Adelta and C fibre input to all types of SDH neurones. Serotonin 0-3 serine dehydratase Rattus norvegicus 71-74 34146338-2 2021 This study assessed the role of a modified maternal diet on the levels of serotonin (5-HT)2C and 5-HT2A receptors in the offspring brain. Serotonin 74-83 5-hydroxytryptamine receptor 2C Rattus norvegicus 85-98 17203017-0 2007 Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies. Serotonin 32-41 5-hydroxytryptamine receptor 2C Homo sapiens 45-51 34143529-8 2021 The concentrations of 5-hydroxytryptamine (5-HT) in platelet-rich plasma (PRP) and serum in SERT KO rats were lower than those in WT rats, but the numbers of enterochromaffin cells (ECs) and the concentrations of 5-HT in colon of SERT KO rats were higher than those of WT rats. Serotonin 22-41 proline rich protein 2-like 1 Rattus norvegicus 74-77 34143529-8 2021 The concentrations of 5-hydroxytryptamine (5-HT) in platelet-rich plasma (PRP) and serum in SERT KO rats were lower than those in WT rats, but the numbers of enterochromaffin cells (ECs) and the concentrations of 5-HT in colon of SERT KO rats were higher than those of WT rats. Serotonin 43-47 proline rich protein 2-like 1 Rattus norvegicus 74-77 17317133-7 2007 Analysis of the platelet marker serotonin (5-HT) suggested that the decrease of platelet BDNF is part of a non-specific release of platelet-derived mediators in this condition. Serotonin 32-41 brain derived neurotrophic factor Homo sapiens 89-93 34376915-3 2021 5-Hydroxytryptamine is a substrate for myeloperoxidase and is converted into reactive tryptamine-4,5-dione. Serotonin 0-19 myeloperoxidase Mus musculus 39-54 17446559-4 2007 Our results showed that serotonin at 200 nM significantly enhanced the expansion of CD34+ cells to early stem/progenitors (CD34+ cells, colony-forming unit-mixed [CFU-GEMM]) and multilineage committed progenitors (burst-forming unit/colony-forming unit-erythroid [BFU/CFU-E], colony-forming unit-granulocyte macrophage, colony-forming unit-megakaryocyte, CD61+ CD41+ cells). Serotonin 24-33 integrin subunit alpha 2b Homo sapiens 361-365 17446559-5 2007 Serotonin also increased nonobese diabetic/severe combined immunodeficient repopulating cells in the expansion culture in terms of human CD45+, CD33+, CD14+ cells, BFU/CFU-E, and CFU-GEMM engraftment in BM of animals 6 weeks post-transplantation. Serotonin 0-9 protein tyrosine phosphatase receptor type C Homo sapiens 137-141 17325130-6 2007 Upon coexpression, serotonin-induced internalization of 5-HT(2B) receptors was accelerated 5-fold and was insensitive to a 5-HT(2B) receptor antagonist. Serotonin 19-28 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 56-63 17325130-6 2007 Upon coexpression, serotonin-induced internalization of 5-HT(2B) receptors was accelerated 5-fold and was insensitive to a 5-HT(2B) receptor antagonist. Serotonin 19-28 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 123-130 17325130-11 2007 Upon coexpression, serotonin-induced 5-HT(2B) receptor internalization became partially Caveolin1-dependent, and serotonin-induced 5-HT(1B) receptor internalization became entirely Caveolin1-independent in a protein kinase Cepsilon-dependent fashion. Serotonin 19-28 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 37-44 34112797-2 2021 Here, we report that energy expenditure is regulated by a subgroup of AgRP neurons that send non-collateral projections to neurons within the dorsal lateral part of dorsal raphe nucleus (dlDRN) expressing the melanocortin 4 receptor (MC4R), which in turn innervate nearby serotonergic (5-HT) neurons. Serotonin 286-290 agouti related neuropeptide Homo sapiens 70-74 17203304-8 2007 The most significant models contributing to serotonin distribution were found for interactions between TPH1 rs4537731 and SLC6A4 haplotypes (P = 0.002) and between HTR1D rs6300 and SLC6A4 haplotypes (P = 0.013). Serotonin 44-53 5-hydroxytryptamine receptor 1D Homo sapiens 164-169 17287506-2 2007 We report that genetic depletion of serotonin, dopamine, and norepinephrine in mice lacking the vesicular monoamine transporter (VMAT2 KO mice) causes an increase in cell death in the superficial layers of the cingulate and retrosplenial cortices during early postnatal life (postnatal days 0-4). Serotonin 36-45 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 129-134 17241828-1 2007 BACKGROUND: Family-based evidence for association at serotonin system genes SLC6A4, HTR1B, HTR2A, and brain-derived neurotrophic factor (BDNF) has been previously reported in obsessive-compulsive disorder (OCD). Serotonin 53-62 brain derived neurotrophic factor Homo sapiens 102-135 17241828-1 2007 BACKGROUND: Family-based evidence for association at serotonin system genes SLC6A4, HTR1B, HTR2A, and brain-derived neurotrophic factor (BDNF) has been previously reported in obsessive-compulsive disorder (OCD). Serotonin 53-62 brain derived neurotrophic factor Homo sapiens 137-141 34112797-2 2021 Here, we report that energy expenditure is regulated by a subgroup of AgRP neurons that send non-collateral projections to neurons within the dorsal lateral part of dorsal raphe nucleus (dlDRN) expressing the melanocortin 4 receptor (MC4R), which in turn innervate nearby serotonergic (5-HT) neurons. Serotonin 286-290 melanocortin 4 receptor Homo sapiens 209-232 34112797-2 2021 Here, we report that energy expenditure is regulated by a subgroup of AgRP neurons that send non-collateral projections to neurons within the dorsal lateral part of dorsal raphe nucleus (dlDRN) expressing the melanocortin 4 receptor (MC4R), which in turn innervate nearby serotonergic (5-HT) neurons. Serotonin 286-290 melanocortin 4 receptor Homo sapiens 234-238 17102981-2 2007 RATIONALE: The selective serotonin (5-HT) reuptake inhibitors (SSRIs) represent the first-line pharmacotherapy for obsessive-compulsive disorder (OCD), and atypical antipsychotic drugs, which block 5-HT2A receptors, are used in augmentation strategies. Serotonin 25-34 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 198-204 17102981-2 2007 RATIONALE: The selective serotonin (5-HT) reuptake inhibitors (SSRIs) represent the first-line pharmacotherapy for obsessive-compulsive disorder (OCD), and atypical antipsychotic drugs, which block 5-HT2A receptors, are used in augmentation strategies. Serotonin 36-40 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 198-204 34065591-7 2021 Surprisingly, adiponectin levels were increased in plasma but reduced in the WAT of high-5HT rats. Serotonin 89-92 adiponectin, C1Q and collagen domain containing Rattus norvegicus 14-25 16806105-3 2007 Serotonin signaling has long been implicated in both BPAD and suicide, and the gene encoding the brain-expressed isoform of tryptophan hydroxlyase (TPH2) has been described. Serotonin 0-9 tryptophan hydroxylase 2 Homo sapiens 148-152 14675129-9 2004 The absence of AANAT suggests that in human gallbladder, HIOMT might be involved in the formation of 5-hydroxytryptamine products other than melatonin. Serotonin 101-120 acetylserotonin O-methyltransferase Homo sapiens 57-62 34348317-9 2021 Finally, the addition of serotonin reduced the production of Th2- and Th17-related cytokines, but elevated IL-10 secretion in cell cultures from both AR and AA patients. Serotonin 25-34 interleukin 10 Homo sapiens 107-112 17158340-6 2007 In contrast, enforced expression of SphK1 protected H9c2 cells from serotonin- or H(2)O(2)-induced apoptosis. Serotonin 68-77 sphingosine kinase 1 Rattus norvegicus 36-41 35413276-7 2022 Our data indicate the basal, non-induced expression of KPEs in the pineal gland, liver, and hearts, with a few first-step enzyme exceptions, such as Tdo and Ido1, and the first-step enzyme of serotonin pathway Tph1. Serotonin 192-201 tryptophan hydroxylase 1 Rattus norvegicus 210-214 17052843-2 2007 The polymorphic cytochrome P450 (CYP) 2C19 metabolizes sex hormones and 5-hydroxytryptamine, which are involved in multiple brain functions. Serotonin 72-91 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 16-42 14642444-13 2003 Phosphorylation of MARCKS has been reported to play an important role in the release of neurotransmitters, such as noradrenaline and serotonin. Serotonin 133-142 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 19-25 14568345-0 2003 Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists. Serotonin 65-74 cholinergic receptor nicotinic alpha 2 subunit Rattus norvegicus 124-156 12958079-14 2003 This 4.96 Mb region contains, among others, the genes for monoamine oxidase A (MAOA) and B (MAOB), which are involved in the oxidative deamination of several neurotransmitters, including dopamine and serotonin. Serotonin 200-209 monoamine oxidase B Homo sapiens 92-96 16973367-2 2006 Efforts to design selective norepinephrine reuptake inhibitors based on SAR from the aryloxypropanamine series of monoamine reuptake inhibitors have led to the identification of a potent new class of dual acting norepinephrine and serotonin reuptake inhibitors, namely the 3-(1H-indol-1-yl)-3-arylpropan-1-amines. Serotonin 231-240 sarcosine dehydrogenase Homo sapiens 72-75 35430211-2 2022 alpha-MSH, a potent POMC-derived neuropeptide, binds to melanocortin 4 receptor (MC4R) in the brain to reduce food intake (via appetite suppression) and increase energy expenditure (via sympathetic nervous system) after integration of central neuronal signal (e.g. serotonin, glutamate) and peripheral signals such as anorexigenic hormones (e.g. leptin, insulin) and nutrient (e.g. glucose). Serotonin 265-274 melanocortin 4 receptor Homo sapiens 56-79 17064686-7 2006 Treatment with serotonin caused strong inductions in the phosphorylation states of Ser(63)-ATF-1 and Ser(133)-CREB. Serotonin 15-24 cAMP responsive element binding protein 1 Homo sapiens 110-114 16958027-1 2006 The TPH1 and TPH2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. Serotonin 70-79 tryptophan hydroxylase 2 Homo sapiens 13-17 16958027-1 2006 The TPH1 and TPH2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. Serotonin 98-107 tryptophan hydroxylase 2 Homo sapiens 13-17 14535948-2 2003 We have previously shown that serotonin excites histaminergic tuberomamillary (TM) neurones by activation of 5-HT2C-receptors and Na+/Ca2+ exchange. Serotonin 30-39 5-hydroxytryptamine receptor 2C Homo sapiens 109-115 35430211-2 2022 alpha-MSH, a potent POMC-derived neuropeptide, binds to melanocortin 4 receptor (MC4R) in the brain to reduce food intake (via appetite suppression) and increase energy expenditure (via sympathetic nervous system) after integration of central neuronal signal (e.g. serotonin, glutamate) and peripheral signals such as anorexigenic hormones (e.g. leptin, insulin) and nutrient (e.g. glucose). Serotonin 265-274 melanocortin 4 receptor Homo sapiens 81-85 35420371-3 2022 The brain-derived neurotrophic factor (BDNF) promotes the growth and sprouting of 5-HT neurons and its differential response to MDMA administration was suggested to mediate dose- and region-dependent 5-HT damage by MDMA. Serotonin 82-86 brain derived neurotrophic factor Homo sapiens 4-37 12874131-0 2003 The regulation of apoptosis by Numb/Notch signaling in the serotonin lineage of Drosophila. Serotonin 59-68 numb Drosophila melanogaster 31-35 12874131-2 2003 In this paper, we examine the role of Numb/Notch signaling in the development of the serotonin lineage of Drosophila and show that it is necessary for regulating apoptosis. Serotonin 85-94 numb Drosophila melanogaster 38-42 16861698-0 2006 A new signaling paradigm for serotonin: use of Crk-associated substrate in arterial contraction. Serotonin 29-38 BCAR1 scaffold protein, Cas family member Rattus norvegicus 47-71 35420371-3 2022 The brain-derived neurotrophic factor (BDNF) promotes the growth and sprouting of 5-HT neurons and its differential response to MDMA administration was suggested to mediate dose- and region-dependent 5-HT damage by MDMA. Serotonin 82-86 brain derived neurotrophic factor Homo sapiens 39-43 12871047-9 2003 Physiological substrates for EMT include the monoamines serotonin, dopamine, noradrenaline, adrenaline and histamine. Serotonin 56-65 solute carrier family 22 member 3 Homo sapiens 29-32 35420371-7 2022 Our findings confirmed that BDNF levels can influence MDMA-induced 5-HT damage, and support BDNF to be a crucial target for neuroprotective interventions of the 5-HT system. Serotonin 161-165 brain-derived neurotrophic factor Rattus norvegicus 92-96 17011525-1 2006 OBJECTIVE: The novel tryptophan hydroxylase isoform (TPH2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. Serotonin 114-123 tryptophan hydroxylase 2 Homo sapiens 53-57 35452231-8 2022 Lastly, we used the yeast platform to characterize 19 serotonin GPCR polymorphisms found in human populations. Serotonin 54-63 vomeronasal 1 receptor 17 pseudogene Homo sapiens 64-68 16894392-5 2006 The increased production of proinflammatory cytokines such as IL-1beta, TNF-alpha or IL-18 resulting from stroke may lead to an amplification of the inflammatory process, particularly in limbic areas, and widespread activation of indoleamine 2,3-dioxygenase (IDO) and subsequently to depletion of serotonin in paralimbic regions such as the ventral lateral frontal cortex, polar temporal cortex and basal ganglia. Serotonin 297-306 interleukin 18 Homo sapiens 85-90 16847459-1 2006 Tryptophan hydroxylase-2 (TPH2) is a newly identified second form of TPH responsible for serotonin synthesis in the brain and has been increasingly implicated as a contributor to the etiology of various psychiatric disorders. Serotonin 89-98 tryptophan hydroxylase 1 Macaca mulatta 26-29 35506370-7 2022 TDO inhibition remains the major common property of antidepressants and TDO induction the most likely mechanism of defective serotonin synthesis in MDD. Serotonin 125-134 tryptophan 2,3-dioxygenase Homo sapiens 72-75 16699769-1 2006 PURPOSE: The purpose of this study was to investigate the monoamine transporter status of dopamine, serotonin and norepinephrine throughout the brain in spinocerebellar ataxia type 2 (SCA2). Serotonin 100-109 ataxin 2 Homo sapiens 153-182 12877987-4 2003 Treatment of mice with serotonin, serotonin precursors, or serotonin agonists results in a quantifiable head twitch response (HTR), which is drug dosage-dependent and dependent on the 5-HT2A receptor system. Serotonin 23-32 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 184-199 12877987-4 2003 Treatment of mice with serotonin, serotonin precursors, or serotonin agonists results in a quantifiable head twitch response (HTR), which is drug dosage-dependent and dependent on the 5-HT2A receptor system. Serotonin 34-43 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 184-199 12877987-4 2003 Treatment of mice with serotonin, serotonin precursors, or serotonin agonists results in a quantifiable head twitch response (HTR), which is drug dosage-dependent and dependent on the 5-HT2A receptor system. Serotonin 34-43 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 184-199 12759158-4 2003 Assuming that genes regulating the serotonin system are involved in the pathogenesis of panic disorder, the authors searched for a genetic association of panic disorder with the serotonin 1A (HTR1A), 2A (HTR2A), and 2C (HTR2C) receptor genes. Serotonin 35-44 5-hydroxytryptamine receptor 2C Homo sapiens 220-225 12694948-6 2003 Our findings suggest that S-100beta could indeed be the mediator of serotonin"s effects on barrel field formation. Serotonin 68-77 S100 calcium binding protein B Rattus norvegicus 26-35 12670312-9 2003 Triple antigen immunohistochemistry and confocal microscopy supported both a pre- and post-synaptic interaction of retinohypothalamic tract (PACAP-immunoreactive) and serotonin projections on vasoactive intestinal peptide- and gastrin-releasing peptide-containing cell bodies in the ventro-lateral suprachiasmatic nucleus. Serotonin 167-176 gastrin releasing peptide Rattus norvegicus 227-252 16699769-1 2006 PURPOSE: The purpose of this study was to investigate the monoamine transporter status of dopamine, serotonin and norepinephrine throughout the brain in spinocerebellar ataxia type 2 (SCA2). Serotonin 100-109 ataxin 2 Homo sapiens 184-188 16903785-5 2006 In npr-1(215V) animals, the switch from weak aerotaxis on food to strong aerotaxis in its absence requires close regulation of the neurotransmitter serotonin in the ADF neurons; high levels of ADF serotonin promote hyperoxia avoidance. Serotonin 148-157 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 3-8 16903785-5 2006 In npr-1(215V) animals, the switch from weak aerotaxis on food to strong aerotaxis in its absence requires close regulation of the neurotransmitter serotonin in the ADF neurons; high levels of ADF serotonin promote hyperoxia avoidance. Serotonin 197-206 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 3-8 35610178-2 2022 Previously, using structure-based virtual screening we found a virtual hit D2AAK1 with nanomolar affinity to dopamine and serotonin receptors important in schizophrenia pharmacotherapy. Serotonin 122-131 AP2 associated kinase 1 Mus musculus 77-81 16737974-2 2006 5-hydroxy-tryptamine (5-HT) resulted in rapid activation of TACE, HB-EGF shedding, EGFR activation, ERK phosphorylation, and longer term increases in DNA content in mesangial cells. Serotonin 0-20 ADAM metallopeptidase domain 17 Homo sapiens 60-64 35600957-5 2022 Changes in the expression of IL-1beta, TNF-alpha, and BDNF in NG2 cells were detected after the addition of 5-HT receptor specific blockers and phospholipase C (PLC) specific activators and inhibitors. Serotonin 108-112 brain-derived neurotrophic factor Rattus norvegicus 54-58 12614326-1 2003 The aim of the present studies was to determine the effects of reduced or absent serotonin (5-HT) transporters (5-HTTs) on 5-HT2A and 5-HT2C receptors. Serotonin 81-90 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 123-140 12588512-1 2003 Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin. Serotonin 0-9 oxytocin/neurophysin I prepropeptide Homo sapiens 154-162 16581042-2 2006 Stimulation of these cells with isoproterenol and serotonin elevated GFAP mRNA levels followed by an increase in its protein contents, thus suggesting that both adrenergic and serotonergic stimulation might induce the differentiation of the glioma cells. Serotonin 50-59 glial fibrillary acidic protein Rattus norvegicus 69-73 35600957-7 2022 5-HT treatment of NG2 cells significantly reduced the expression of IL-1beta and BDNF mRNA and increased the expression of TNF-alpha. Serotonin 0-4 brain-derived neurotrophic factor Rattus norvegicus 81-85 16581042-4 2006 Further studies showed that the elevation of GFAP mRNA levels induced by isoproterenol and serotonin as well as progesterone was abolished by pretreatment of the glioma cells with finasteride, an inhibitor of 5alpha-reduced steroid production. Serotonin 91-100 glial fibrillary acidic protein Rattus norvegicus 45-49 35600957-10 2022 These results indicated that 5-HT affected IL-1beta, TNF-alpha, and BDNF secretion from NG2 cells via the 5-HT1A, 5-HT2A, 5-HT3, 5-HT6 receptors and the PLC signaling pathway. Serotonin 29-33 brain-derived neurotrophic factor Rattus norvegicus 68-72 16581042-5 2006 Moreover, the stimulatory actions of isoproterenol and serotonin on GFAP gene expression were inhibited by pretreatment with a GABA(A) receptor antagonist bicuculline and a progesterone receptor antagonist RU486. Serotonin 55-64 glial fibrillary acidic protein Rattus norvegicus 68-72 35181916-8 2022 We found that critical developmental periods of serotonin depletion caused degeneration and swelling of neurons as well as significant neuronal loss in the hippocampal CA1, CA3, and dentate gyrus (DG) areas. Serotonin 48-57 carbonic anhydrase 3 Rattus norvegicus 173-176 12566172-6 2003 The aim of the present study was to investigate the effects of serotonin depletion on acute CRF-induced c-fos expression, corticosterone levels and behavioural responses. Serotonin 63-72 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 104-109 35383830-7 2022 As a proof-of-concept, we visualized GPCR signaling dynamics of 5 dopamine receptors and 12 serotonin receptors, and found heterogeneity between GPCRs and between cells. Serotonin 92-101 vomeronasal 1 receptor 17 pseudogene Homo sapiens 37-41 12591155-7 2003 Furthermore, evidence was obtained that (i) adrenaline and noradrenaline share the same binding site, and that this site would correspond to a repeated sequence present in the SCO-spondin, the major protein component of RF; and (ii) serotonin has its own binding site in RF. Serotonin 233-242 SCO-spondin Bos taurus 176-187 16406667-0 2006 5-HT1A receptor activation counteracts c-Fos immunoreactivity induced in serotonin neurons of the raphe nuclei after immobilization stress in the male rat. Serotonin 73-82 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 39-44 35563331-1 2022 Serotonin is synthetized through the action of tryptophan hydroxylase (TPH) enzymes. Serotonin 0-9 tryptophan hydroxylase 1 Rattus norvegicus 47-69 12693968-3 2003 Suppression of GP IIb-IIIa receptor activity by both preparations led to 100% inhibition of [(14)C]serotonin secretion from dense granules upon platelet activation with ADP, to partial inhibition upon activation with thromboxane A(2) analog U46619 (by 60-70%) and thrombin at 0.1 U/ml (by 40-50%), but did not decrease serotonin secretion induced by thrombin at 1 U/ml. Serotonin 99-108 integrin subunit alpha 2b Homo sapiens 15-21 12693968-3 2003 Suppression of GP IIb-IIIa receptor activity by both preparations led to 100% inhibition of [(14)C]serotonin secretion from dense granules upon platelet activation with ADP, to partial inhibition upon activation with thromboxane A(2) analog U46619 (by 60-70%) and thrombin at 0.1 U/ml (by 40-50%), but did not decrease serotonin secretion induced by thrombin at 1 U/ml. Serotonin 319-328 integrin subunit alpha 2b Homo sapiens 15-21 12693968-5 2003 MonAB CRC54 against GP IIb-IIIa, which induced its interaction with fibrinogen and platelet aggregation, also stimulated serotonin and P-selectin secretion. Serotonin 121-130 integrin subunit alpha 2b Homo sapiens 20-26 12693968-8 2003 Upon platelet activation by concanavalin A (Con A), caused by clusterization of membrane glycoproteins, GP IIb-IIIa blockade only slightly (by 15-20%) decreased serotonin secretion. Serotonin 161-170 integrin subunit alpha 2b Homo sapiens 104-110 35563331-1 2022 Serotonin is synthetized through the action of tryptophan hydroxylase (TPH) enzymes. Serotonin 0-9 tryptophan hydroxylase 1 Rattus norvegicus 71-74 35563331-2 2022 While the TPH2 isoform is responsible for the production of serotonin in the brain, TPH1 is expressed in peripheral organs. Serotonin 60-69 tryptophan hydroxylase 2 Rattus norvegicus 10-14 35571111-10 2022 KOR are also acting as inhibitory heteroreceptors on serotonin neurons. Serotonin 53-62 opioid receptor kappa 1 Homo sapiens 0-3 12974395-0 2002 Serotonin/dopamine interaction--focus on 5-HT2C receptor, a new target of psychotropic drugs. Serotonin 0-9 5-hydroxytryptamine receptor 2C Homo sapiens 41-47 12974395-4 2002 This article reviews current knowledge on interaction between 5-hydroxytryptamine (5-HT), acting at 5-HT2C receptors in the central dopamine (DA) systems. Serotonin 62-81 5-hydroxytryptamine receptor 2C Homo sapiens 100-106 12472905-4 2002 Concomitant blockade of tyrosine kinases by genistein suppressed all the up-regulating effects of BDNF and cAMP on 5-hydroxytryptamine (5-HT) neurones. Serotonin 115-134 brain-derived neurotrophic factor Rattus norvegicus 98-102 14516688-12 2002 The co-expression of tphD1, tphD2 and 5-HT in the zebrafish diencephalon appears in striking contrast to the situation in mammals, where diencephalic serotonin results from re-uptake rather than from local production. Serotonin 150-159 tryptophan hydroxylase 1b Danio rerio 28-33 12444499-0 2002 Differential characteristics of endogenous serotonin-mediated synaptic transmission in the hippocampal CA1 and CA3 fields of anaesthetized rats. Serotonin 43-52 carbonic anhydrase 3 Rattus norvegicus 111-114 35148838-0 2022 GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. Serotonin 53-62 G protein-coupled receptor 35 Mus musculus 0-5 12213812-7 2002 Furthermore, the mitogen-activated protein kinase kinase (MEK) inhibitor PD98059 blocked serotonin-dependent activation of p44/42 MAPK (pERK1/2), a downstream effector of PKC and also down-regulated MMP-13 protein expression. Serotonin 89-98 matrix metallopeptidase 13 Rattus norvegicus 199-205 12213812-9 2002 From these studies, serotonin, binding through the 5-HT(2A) receptor, initiates a signaling cascade whereby stimulation of PLC leads to the activation of PKC and subsequently the ERK1/2 pathway, which ultimately results in MMP-13 production. Serotonin 20-29 matrix metallopeptidase 13 Rattus norvegicus 223-229 12373419-1 2002 RATIONALE: 5-HT(1B) receptors are thought to be one of the receptor subtypes that mediate the inhibitory control of serotonin on food intake and satiety. Serotonin 116-125 5-hydroxytryptamine receptor 1B Rattus norvegicus 11-18 35148838-4 2022 Using a bioassay, we find that serum and activated platelet supernatant stimulate GPR35, and we identify the platelet-derived serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) as a GPR35 ligand. Serotonin 126-135 G protein-coupled receptor 35 Mus musculus 188-193 12421573-1 2002 BACKGROUND: Serotonin (5-HT) has negative immunoregulatory effects by reducing the interferon-gamma (IFNgamma)/interleukin-10 (IL-10) production ratio by stimulated immune cells. Serotonin 12-21 interleukin 10 Homo sapiens 111-125 35001075-0 2022 Acute sleep deprivation upregulates serotonin 2A receptors in the frontal cortex of mice via the immediate early gene Egr3. Serotonin 36-45 early growth response 3 Mus musculus 118-122 12421573-1 2002 BACKGROUND: Serotonin (5-HT) has negative immunoregulatory effects by reducing the interferon-gamma (IFNgamma)/interleukin-10 (IL-10) production ratio by stimulated immune cells. Serotonin 12-21 interleukin 10 Homo sapiens 127-132 35177004-4 2022 METHODS: Utilizing immunohistochemistry, the localization of 5-HT and of 5-HT1B/1D/1F receptors was examined in rat trigeminal ganglion (TG) and combined with quantitative polymerase chain reaction to quantify the level of expression for 5-HT1B/1D/1F receptors in the TG. Serotonin 61-65 5-hydroxytryptamine receptor 1B Rattus norvegicus 238-244 12003787-0 2002 Src modulates serotonin-induced calcium signaling by regulating phosphatidylinositol 4,5-bisphosphate. Serotonin 14-23 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 0-3 35111079-9 2021 In this study, we prepared RNA probes for chick orthologs of the following serotonin receptor genes: 5-HTR1A, 5-HTR1B, 5-HTR1D, 5-HTR1E, 5-HTR1F, 5-HTR2A, 5-HTR2B, 5-HTR2C, 5-HTR3A, 5-HTR4, 5-HTR5A, and 5-HTR7. Serotonin 75-84 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled Gallus gallus 205-209 12003787-2 2002 Stimulation of cultured rat tracheal smooth muscle cells with serotonin (5-HT) induced an increase in Src activity, Ca(2+) mobilization, and contraction (decrease in cell area). Serotonin 62-71 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 102-105 12022964-9 2002 These results suggest that 5-HT(1B) autoreceptors in unstressed and acutely stressed animals differ, indicating the importance of state versus trait changes in serotonin function in animal models of anxiety and depression. Serotonin 160-169 5-hydroxytryptamine receptor 1B Rattus norvegicus 27-34 12052171-1 2002 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) catalyzes the rate-limiting step in the biosynthesis of the circadian hormone melatonin from serotonin. Serotonin 167-176 aralkylamine N-acetyltransferase Homo sapiens 0-29 12052171-1 2002 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) catalyzes the rate-limiting step in the biosynthesis of the circadian hormone melatonin from serotonin. Serotonin 167-176 aralkylamine N-acetyltransferase Homo sapiens 31-65 12052171-1 2002 Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) catalyzes the rate-limiting step in the biosynthesis of the circadian hormone melatonin from serotonin. Serotonin 167-176 aralkylamine N-acetyltransferase Homo sapiens 67-72 11859080-0 2002 The serotonin binding site of human and murine 5-HT2B receptors: molecular modeling and site-directed mutagenesis. Serotonin 4-13 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 47-53 11859080-1 2002 Bacteriorhodopsin and rhodopsin crystal structures were used as templates to build structural models of the mouse and human serotonin (5-HT)-2B receptors (5-HT(2B)Rs). Serotonin 124-133 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 155-162 11919704-8 2002 The l(4)16/ciD line, containing a mutation in CaM kinase II, eliminates pacemaker responsiveness to serotonin but is without effect on norepinephrine sensitivity. Serotonin 100-109 Calcium/calmodulin-dependent protein kinase II Drosophila melanogaster 46-59 11801601-1 2002 5-Hydroxytryptamine 2A (5-HT2A) receptors are essential for the actions of serotonin (5-hydroxytryptamine (5-HT)) on physiological processes as diverse as vascular smooth muscle contraction, platelet aggregation, perception, and emotion. Serotonin 75-84 5-hydroxytryptamine receptor 2A Bos taurus 24-30 11801601-1 2002 5-Hydroxytryptamine 2A (5-HT2A) receptors are essential for the actions of serotonin (5-hydroxytryptamine (5-HT)) on physiological processes as diverse as vascular smooth muscle contraction, platelet aggregation, perception, and emotion. Serotonin 86-105 5-hydroxytryptamine receptor 2A Bos taurus 24-30 11936691-0 2002 Determination of the cell lytic properties of amphiphilic inhibitors of the cytosolic phospholipase A2 against human platelets by measuring the liberation of serotonin with high-performance liquid chromatography and fluorescence detection. Serotonin 158-167 phospholipase A2 group IVA Homo sapiens 76-102 11880481-0 2002 Activation by serotonin and noradrenaline of vasopressin and oxytocin expression in the mouse paraventricular and supraoptic nuclei. Serotonin 14-23 oxytocin Mus musculus 61-69 11880481-1 2002 Noradrenaline and serotonin are known to control arginine-vasopressin (AVP) and oxytocin (OT) secretion in the systemic circulation. Serotonin 18-27 oxytocin Mus musculus 80-88 11827701-9 2002 In contrast, the response to 5HT was attenuated in the HTG-SIR group compared to controls (low and high dose by, respectively, -60 and -44%, both P<0.01), and tended to be lower than in the HTG-MIR group (-43%, P=0.068 and -41%, P=0.100, respectively). Serotonin 29-32 membrane associated ring-CH-type finger 8 Homo sapiens 197-200 11882579-1 2002 Previous studies have established a role for 5-hydroxytryptamine (5-HT)(2B) and 5-HT(1B) receptors in mediating enhanced contraction to serotonin (5-HT) in arteries from hypertensive deoxycorticosterone acetate (DOCA)-salt rats. Serotonin 136-145 5-hydroxytryptamine receptor 1B Rattus norvegicus 80-87 11573980-0 2001 Serotonin modulates expression of VIP and GRP mRNA via the 5-HT(1B) receptor in the suprachiasmatic nucleus of the rat. Serotonin 0-9 gastrin releasing peptide Rattus norvegicus 42-45 11573980-0 2001 Serotonin modulates expression of VIP and GRP mRNA via the 5-HT(1B) receptor in the suprachiasmatic nucleus of the rat. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 59-66 11573980-3 2001 In the present study we investigated the involvement of serotonin (5-HT) in the expression of VIP and GRP messenger RNA in the SCN of the rat. Serotonin 56-65 gastrin releasing peptide Rattus norvegicus 102-105 11567651-0 2001 MS-377, a novel selective sigma(1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain. Serotonin 107-116 sigma non-opioid intracellular receptor 1 Rattus norvegicus 26-43 11559032-0 2001 A putative metabolite of serotonin, tryptamine-4,5-dione, is an irreversible inhibitor of tryptophan hydroxylase: possible relevance to the serotonergic neurotoxicity of methamphetamine. Serotonin 25-34 tryptophan hydroxylase 1 Rattus norvegicus 90-112 11532381-1 2001 Citalopram is a selective serotonin reuptake inhibitor that is N-demethylated to N-desmethylcitalopram partially by CYP2C19 and partially by CYP3A4 and N-desmethylcitalopram is further N-demethylated by CYP2D6 to the likewise inactive metabolite di-desmethylcitalopram. Serotonin 26-35 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 116-123 11445277-1 2001 Effect of caffeine on the expression of tryptophan hydroxylase (TPH), rate limiting enzyme of serotonin synthesis, in dorsal and median raphe was investigated via immunohistochemistry. Serotonin 94-103 tryptophan hydroxylase 1 Rattus norvegicus 64-67 11358440-3 2001 We have previously demonstrated a role for serotonin (5-HT) as one potential modulator of respiratory recovery following cervical hemisection, a mechanism that likely occurs via 5-HT2A and/or 5-HT2C receptors. Serotonin 43-52 5-hydroxytryptamine receptor 2C Rattus norvegicus 192-198 11270917-9 2001 Tricyclic antidepressants, selective serotonin reuptake inhibitors, and serotonin-noradrenaline reuptake inhibitors, as well as the immediate precursor of serotonin, have a common, negative immunoregulatory effect by suppressing the IFN-gamma/IL-10 production ratio. Serotonin 72-81 interleukin 10 Homo sapiens 243-248 11238110-0 2001 Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells. Serotonin 0-9 coagulation factor III, tissue factor Rattus norvegicus 36-49 11167155-4 2001 The aim of the present study was to investigate, if PCB-induced effects on concentrations of catecholamines and serotonin can be attributed to PCB-induced reductions in thyroid hormone concentrations. Serotonin 112-121 pyruvate carboxylase Rattus norvegicus 52-55 11167155-4 2001 The aim of the present study was to investigate, if PCB-induced effects on concentrations of catecholamines and serotonin can be attributed to PCB-induced reductions in thyroid hormone concentrations. Serotonin 112-121 pyruvate carboxylase Rattus norvegicus 143-146 11162889-13 2000 In contrast, Fra-1 expression and binding are serotonin-dependent suggesting that the activation of Fra-1 may be a key component of collagenase transcriptional activation. Serotonin 46-55 FOS like 1, AP-1 transcription factor subunit Rattus norvegicus 13-18 11162889-13 2000 In contrast, Fra-1 expression and binding are serotonin-dependent suggesting that the activation of Fra-1 may be a key component of collagenase transcriptional activation. Serotonin 46-55 FOS like 1, AP-1 transcription factor subunit Rattus norvegicus 100-105 10926932-1 2000 The gamma-aminobutyric acid (GABA) transporter GAT-1 is a prototype of a large family of neurotransmitter transporters that includes those of dopamine and serotonin. Serotonin 155-164 solute carrier family 6 member 12 Rattus norvegicus 47-52 11294005-3 2000 In the present study, the effect of A beta(1-42) upon the release of granular hexosaminidase and serotonin has been investigated using the cognate rat mast cell line, RBL-2H3. Serotonin 97-106 amyloid beta precursor protein Rattus norvegicus 36-42 10984628-5 2000 Double fluorescence immunohistochemistry for c-Fos and serotonin revealed that PAG/NRD/EW neurons expressing c-Fos were non-serotonergic. Serotonin 55-64 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 109-114 10993216-5 2000 These results suggest that serotonin and noradrenaline are likely involved in the modulation of the expression of Fos-ir cells in response to the urine in the accessory olfactory bulb. Serotonin 27-36 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 114-117 10864974-0 2000 Nigrostriatal lesions alter oral dyskinesia and c-Fos expression induced by the serotonin agonist 1-(m-chlorophenyl)piperazine in adult rats. Serotonin 80-89 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 48-53 10911894-0 2000 Dopamine, serotonin, and noradrenaline strongly inhibit the direct perforant path-CA1 synaptic input, but have little effect on the Schaffer collateral input. Serotonin 10-19 carbonic anhydrase 1 Homo sapiens 82-85 10833495-0 2000 Serotonin released from intestinal enterochromaffin cells mediates luminal non-cholecystokinin-stimulated pancreatic secretion in rats. Serotonin 0-9 cholecystokinin Rattus norvegicus 79-94 10804232-4 2000 In primary hippocampal cell cultures, serotonin (5-HT) increases glucocorticoid receptor expression, and this effect appears to be mediated by increased cAMP levels. Serotonin 38-47 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 65-88 10833301-6 2000 Serotonin also increased BDNF mRNA and protein in embryonic raphe cultures. Serotonin 0-9 brain-derived neurotrophic factor Rattus norvegicus 25-29 10833301-8 2000 Taken together, our data indicate that serotonin acts on 5-HT1(A) autoreceptors, causing up-regulation of BDNF, which activates trkB to promote serotonergic phenotype-specific markers. Serotonin 39-48 brain-derived neurotrophic factor Rattus norvegicus 106-110 10767055-8 2000 The mechanisms underlying dendritic remodeling in CA3 pyramidal neurons are likely to involve stress-induced changes in glucocorticoids and in 5HT and other transmitters. Serotonin 143-146 carbonic anhydrase 3 Rattus norvegicus 50-53 10790876-0 2000 Serotonin depletion decreases light induced c-fos in the rat suprachiasmatic nucleus. Serotonin 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 44-49 10848798-3 2000 The normal range (median, 2.5 and 97.5 percentiles) of serotonin release from platelets in healthy subjects (n = 149) is 38 ng/ml (19 and 62) measured by EIA-SRA. Serotonin 55-64 steroid receptor RNA activator 1 Homo sapiens 158-161 10722724-1 2000 Arylalkylamine N-acetyltransferase (AANAT) catalyzes the reaction of serotonin with acetyl-CoA to form N-acetylserotonin and plays a major role in the regulation of the melatonin circadian rhythm in vertebrates. Serotonin 69-78 aralkylamine N-acetyltransferase Homo sapiens 0-34 10722724-1 2000 Arylalkylamine N-acetyltransferase (AANAT) catalyzes the reaction of serotonin with acetyl-CoA to form N-acetylserotonin and plays a major role in the regulation of the melatonin circadian rhythm in vertebrates. Serotonin 69-78 aralkylamine N-acetyltransferase Homo sapiens 36-41 16513807-4 2006 We also show that Galpha(s) is the major Galpha isoform in fly brains, and define a second AC pathway stimulated by serotonin and histamine requiring NF1 and Galpha(s), as well as a third, classical Galpha(s)-dependent AC pathway, which is stimulated by Phe-Met-Arg-Phe-amide (FMRFamide) and dopamine. Serotonin 116-125 Neurofibromin 1 Drosophila melanogaster 150-164 16759340-2 2006 The focus of the present study is to determine whether genetic variation in the tryptophan hydroxylase-2 (TPH2) gene, which encodes the enzyme responsible for synthesis of the majority of the serotonin contained in neurons of the central nervous system, contributes to the pathophysiology of cocaine dependence. Serotonin 192-201 tryptophan hydroxylase 2 Homo sapiens 80-104 16759340-2 2006 The focus of the present study is to determine whether genetic variation in the tryptophan hydroxylase-2 (TPH2) gene, which encodes the enzyme responsible for synthesis of the majority of the serotonin contained in neurons of the central nervous system, contributes to the pathophysiology of cocaine dependence. Serotonin 192-201 tryptophan hydroxylase 2 Homo sapiens 106-110 16395128-7 2006 An intronic genetic marker of the neuronal tryptophan hydroxylase-2 (the rate-limiting enzyme for serotonin biosynthesis) gene, however, was associated with the Stop Signal reaction time. Serotonin 98-107 tryptophan hydroxylase 2 Homo sapiens 43-67 15959855-3 2006 The aim of the present study was therefore to investigate if platelet MAO-B activity could be related to hormonal and temperature responses to the serotonin active drug DL-fenfluramine in healthy men. Serotonin 147-156 monoamine oxidase B Homo sapiens 70-75 16310967-9 2006 These data confirm alterations in hypothalamic-adrenalaxis function that may stem from decreases in glucocorticoid receptor levels, in response to early adverse experiences, and demonstrate that these alterations are reversed by serotonin re-uptake inhibitor pretreatment. Serotonin 229-238 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 100-123 16529815-2 2006 Research in humans and rats have indicated that increased serotonin levels in the central nervous system elevate the ejaculatory threshold, probably via 5-HT(1B) and 5-HT(2C) receptors, whereas depletion of serotonin decreases the ejaculatory threshold. Serotonin 58-67 5-hydroxytryptamine receptor 1B Rattus norvegicus 153-160 16245070-1 2005 The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Serotonin 65-74 tryptophan hydroxylase 2 Homo sapiens 4-28 16245070-1 2005 The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Serotonin 65-74 tryptophan hydroxylase 2 Homo sapiens 35-39 16245070-1 2005 The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Serotonin 76-80 tryptophan hydroxylase 2 Homo sapiens 4-28 16245070-1 2005 The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Serotonin 76-80 tryptophan hydroxylase 2 Homo sapiens 35-39 16245070-1 2005 The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Serotonin 76-80 tryptophan hydroxylase 2 Homo sapiens 122-126 16144662-2 2005 It is well known that stress induces tryptophan hydroxylase (TPH) activation, resulting in increased serotonin (5-HT) synthesis. Serotonin 101-110 tryptophan hydroxylase 1 Rattus norvegicus 37-59 16144662-2 2005 It is well known that stress induces tryptophan hydroxylase (TPH) activation, resulting in increased serotonin (5-HT) synthesis. Serotonin 101-110 tryptophan hydroxylase 1 Rattus norvegicus 61-64 15993514-4 2005 We propose that downstream activation of MC4R-expressing neurons substantially contributes to serotonin"s effects on energy homeostasis. Serotonin 94-103 melanocortin 4 receptor Homo sapiens 41-45 15888447-8 2005 In support of this suggestion, treatment with serotonin enhanced binding of CREB1 to its promoter region and increased mRNA levels of creb1. Serotonin 46-55 cAMP responsive element binding protein 1 Homo sapiens 76-81 15888447-8 2005 In support of this suggestion, treatment with serotonin enhanced binding of CREB1 to its promoter region and increased mRNA levels of creb1. Serotonin 46-55 cAMP responsive element binding protein 1 Homo sapiens 134-139 16142281-1 2005 We demonstrated a possibility of inducing antibody production against serotonin in high titers in rats by active immunization with serotonin conjugated with a homologous protein carrier (rat serum albumin) and with a foreign protein carrier (BSA). Serotonin 70-79 albumin Rattus norvegicus 191-204 16142281-1 2005 We demonstrated a possibility of inducing antibody production against serotonin in high titers in rats by active immunization with serotonin conjugated with a homologous protein carrier (rat serum albumin) and with a foreign protein carrier (BSA). Serotonin 131-140 albumin Rattus norvegicus 191-204 15663485-5 2005 A K4.45M mutation decreased serotonin-dependent activity (Emax) of the rat 5-HT2C receptor by 60% and that of the C. elegans homologue by 40%, as determined by a fluorometric plate-based calcium assay. Serotonin 28-37 5-hydroxytryptamine receptor 2C Rattus norvegicus 75-81 15663485-8 2005 The same mutations of the cognate C7.45 in rat 5-HT2C produced a smaller fourfold change in the affinity for serotonin and decreased agonist efficacy by up to 50%. Serotonin 109-118 5-hydroxytryptamine receptor 2C Rattus norvegicus 47-53 15522306-5 2004 Genetic interactions between tax-6 and several mutants including egl-30 and egl-10, which are known to be involved in G-protein signaling pathways suggest that calcineurin indeed regulates locomotion and serotonin-mediated egg laying through goa-1(Goalpha) and egl-30(Gqalpha). Serotonin 204-213 Regulator of G-protein signaling egl-10 Caenorhabditis elegans 76-82 15547445-1 2004 OBJECTIVE: Brain-derived neurotrophic factor (BDNF) influences dopamine and serotonin neurotransmitters that are heavily linked to addiction. Serotonin 76-85 brain derived neurotrophic factor Homo sapiens 11-44 15547445-1 2004 OBJECTIVE: Brain-derived neurotrophic factor (BDNF) influences dopamine and serotonin neurotransmitters that are heavily linked to addiction. Serotonin 76-85 brain derived neurotrophic factor Homo sapiens 46-50 15587807-3 2004 The neuronal effects of antibody SMP-69 were similar to changes in the activity of cells LP11 and RP11 induced by serotonin and cAMP, and to changes seen when snails acquired nociceptive sensitization. Serotonin 114-123 pre-mRNA processing factor 31 Homo sapiens 98-102 15374669-2 2004 These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Serotonin 52-56 brain derived neurotrophic factor Homo sapiens 86-90 15374669-2 2004 These two signals co-regulate one another such that 5-HT stimulates the expression of BDNF, and BDNF enhances the growth and survival of 5-HT neurons. Serotonin 137-141 brain derived neurotrophic factor Homo sapiens 96-100 15322265-1 2004 The neurotoxin 1-methyl-4-(2"-aminophenyl)-1,2,3,6-tetrahydropyridine (2"-NH(2)-MPTP) damages forebrain serotonin (5-HT) and norepinephrine (NE) nerve terminals while sparing striatal dopaminergic innervation. Serotonin 104-113 protein tyrosine phosphatase, non-receptor type 2 Mus musculus 80-84 15517368-8 2004 Nuclear CDX2 immunoreactivity was found in all EC-cells (serotonin-producing cells), in about 10% of G-cells (gastrin-producing cells), in about 30% of GIP-cells (gastric inhibitory peptide cells) and in a few motilin-positive cells of the normal intestinal mucosa, while other gastrointestinal endocrine cell types were CDX2 negative. Serotonin 57-66 caudal type homeobox 2 Homo sapiens 8-12 15309378-1 2004 Desensitisation of 5-HT(1A) and 5-HT(1B) autoreceptors is thought to be the mechanism underlying the therapeutic effects of fluoxetine and other selective serotonin re-uptake inhibitors (SSRIs) when these are administered chronically, while blockade of these autoreceptors occurring on administration of an SSRI together with an autoreceptor antagonist is responsible for the acute increase in 5-HT levels in vivo observed under these circumstances. Serotonin 155-164 5-hydroxytryptamine receptor 1B Rattus norvegicus 32-39 15174080-9 2004 CRF-R2 mRNA was mainly expressed at the middle and caudal levels of the DR. At midlevels, CRF-R2 mRNA was expressed exclusively in serotonin neurons, whereas, at caudal levels, approximately half the CRF-R2 mRNA was expressed in GABAergic neurons. Serotonin 131-140 corticotropin releasing hormone receptor 2 Rattus norvegicus 0-6 15174080-9 2004 CRF-R2 mRNA was mainly expressed at the middle and caudal levels of the DR. At midlevels, CRF-R2 mRNA was expressed exclusively in serotonin neurons, whereas, at caudal levels, approximately half the CRF-R2 mRNA was expressed in GABAergic neurons. Serotonin 131-140 corticotropin releasing hormone receptor 2 Rattus norvegicus 90-96 15174080-9 2004 CRF-R2 mRNA was mainly expressed at the middle and caudal levels of the DR. At midlevels, CRF-R2 mRNA was expressed exclusively in serotonin neurons, whereas, at caudal levels, approximately half the CRF-R2 mRNA was expressed in GABAergic neurons. Serotonin 131-140 corticotropin releasing hormone receptor 2 Rattus norvegicus 90-96 15003288-1 2004 In the mouse and the rat brain, the Ets transcription factor pet-1 is exclusively expressed in the central serotonin (5-hydroxytryptaminergic: 5-HT) system. Serotonin 107-116 FEV transcription factor, ETS family member Rattus norvegicus 61-66 14960297-2 2004 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin biosynthesis, but brainstem TPH mRNA expression has been difficult to measure and study. Serotonin 60-69 tryptophan hydroxylase 1 Rattus norvegicus 0-22 14960297-2 2004 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in serotonin biosynthesis, but brainstem TPH mRNA expression has been difficult to measure and study. Serotonin 60-69 tryptophan hydroxylase 1 Rattus norvegicus 24-27 14960297-11 2004 The robust expression of TPH2 in brainstem should facilitate studies on the transcriptional regulation of raphe serotonin biosynthesis. Serotonin 112-121 tryptophan hydroxylase 2 Rattus norvegicus 25-29 14744469-2 2004 We examined the effect of immobilization stress (IMO) on gene expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, and the role of cortisol in that response. Serotonin 134-143 tryptophan hydroxylase 1 Rattus norvegicus 76-98 14744469-2 2004 We examined the effect of immobilization stress (IMO) on gene expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin biosynthesis, and the role of cortisol in that response. Serotonin 134-143 tryptophan hydroxylase 1 Rattus norvegicus 100-103 14600156-2 2004 Angiotensin II (Ang II) and 5-hydroxytryptamine (5-HT) stimulated both ERK and NHE-1 activities, with activation of NHE-1 preceding that of ERK. Serotonin 28-47 solute carrier family 9 member A1 Rattus norvegicus 79-84 14600156-2 2004 Angiotensin II (Ang II) and 5-hydroxytryptamine (5-HT) stimulated both ERK and NHE-1 activities, with activation of NHE-1 preceding that of ERK. Serotonin 28-47 solute carrier family 9 member A1 Rattus norvegicus 116-121 14661109-4 2004 We have analyzed the distribution of CPE in the antropyloric mucosa of rat stomach and report that gastrin cells and progenitor gastrin-somatostatin (G/D) cells express CPE while mature somatostatin cells and the majority of serotonin cells fail to express CPE. Serotonin 225-234 gastrin Rattus norvegicus 99-106 14661109-4 2004 We have analyzed the distribution of CPE in the antropyloric mucosa of rat stomach and report that gastrin cells and progenitor gastrin-somatostatin (G/D) cells express CPE while mature somatostatin cells and the majority of serotonin cells fail to express CPE. Serotonin 225-234 gastrin Rattus norvegicus 128-135 14660752-8 2003 The SLC6A14 gene is an interesting novel candidate for obesity because it encodes an amino acid transporter, which potentially regulates tryptophan availability for serotonin synthesis and thus possibly affects appetite control. Serotonin 165-174 solute carrier family 6 member 14 Homo sapiens 4-11 10660896-10 2000 The localization of 5-HT1B receptors to the membrane of preterminal axons suggests that they control transmitter release from nonserotonin as well as serotonin neurons by mediating serotonin effects on axonal conduction. Serotonin 129-138 5-hydroxytryptamine receptor 1B Rattus norvegicus 20-26 10660896-10 2000 The localization of 5-HT1B receptors to the membrane of preterminal axons suggests that they control transmitter release from nonserotonin as well as serotonin neurons by mediating serotonin effects on axonal conduction. Serotonin 150-159 5-hydroxytryptamine receptor 1B Rattus norvegicus 20-26 10686528-1 2000 The role of serotonin (5-HT) in the regulation of growth hormone (GH) secretion remains unclear due to the existence of many different receptors that mediate the 5-HT actions, and the lack of suitable specific agonist and antagonist drugs. Serotonin 12-21 somatotropin Canis lupus familiaris 50-64 10686528-1 2000 The role of serotonin (5-HT) in the regulation of growth hormone (GH) secretion remains unclear due to the existence of many different receptors that mediate the 5-HT actions, and the lack of suitable specific agonist and antagonist drugs. Serotonin 12-21 somatotropin Canis lupus familiaris 66-68 11450029-0 2000 Spinal cord injury induced c-fos expression is reduced by p-CPA, a serotonin synthesis inhibitor. Serotonin 67-76 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 27-32 11450029-2 2000 Influence of serotonin on upregulation of cellular-fos (c-fos) following a focal spinal cord injury was examined using immunohistochemistry in a rat model. Serotonin 13-22 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 42-54 11450029-2 2000 Influence of serotonin on upregulation of cellular-fos (c-fos) following a focal spinal cord injury was examined using immunohistochemistry in a rat model. Serotonin 13-22 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 56-61 11450029-5 2000 Pretreatment with p-CPA, a serotonin synthesis inhibitor, significantly attenuated the c-fos upregulation along with the edematous expansion of the cord. Serotonin 27-36 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 87-92 10658625-0 2000 c-fos expression, behavioural, endocrine and autonomic responses to acute social stress in male rats after chronic restraint: modulation by serotonin. Serotonin 140-149 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 10658625-7 2000 Serotonin depletion reduced the expression of c-fos in the frontal cortex, lateral preoptic area, medial amygdala, central gray, medial and dorsal raphe, and locus coeruleus after social stress, but this was not altered by previous restraint. Serotonin 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 46-51 14645470-0 2003 Opioid modulation of scratching and spinal c-fos expression evoked by intradermal serotonin. Serotonin 82-91 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 43-48 34136961-0 2022 Kappa Opioid Receptor Mediated Differential Regulation of Serotonin and Dopamine Transporters in Mood and Substance Use Disorder. Serotonin 58-67 opioid receptor kappa 1 Homo sapiens 0-21 12972322-1 2003 This study was conducted to determine if serotonin (5-hydroxytryptamine; 5-HT) system correlates with the hypothalamic expression of cocaine-amphetamine-regulated transcript (CART) gene. Serotonin 41-50 CART prepropeptide Rattus norvegicus 133-173 12972322-1 2003 This study was conducted to determine if serotonin (5-hydroxytryptamine; 5-HT) system correlates with the hypothalamic expression of cocaine-amphetamine-regulated transcript (CART) gene. Serotonin 41-50 CART prepropeptide Rattus norvegicus 175-179 12972322-1 2003 This study was conducted to determine if serotonin (5-hydroxytryptamine; 5-HT) system correlates with the hypothalamic expression of cocaine-amphetamine-regulated transcript (CART) gene. Serotonin 52-71 CART prepropeptide Rattus norvegicus 133-173 12972322-1 2003 This study was conducted to determine if serotonin (5-hydroxytryptamine; 5-HT) system correlates with the hypothalamic expression of cocaine-amphetamine-regulated transcript (CART) gene. Serotonin 52-71 CART prepropeptide Rattus norvegicus 175-179 10717436-9 2000 These results indicate that during acute thalamic hypoxia an increased release of noradrenaline, serotonin, histamine and nitric oxide is responsible for transforming I(h) into an instantaneously activating current via cyclic AMP- and cyclic GMP-mediated mechanisms. Serotonin 97-106 5'-nucleotidase, cytosolic II Homo sapiens 242-245 12874224-5 2003 Accordingly, the mutated HLA-G transfectants were less effective in the inhibition of NK killing and RBL/LIR-1 induced serotonin release. Serotonin 119-128 major histocompatibility complex, class I, G Homo sapiens 25-30 34136961-5 2022 Also, we discuss the recent findings on KOR-mediated differential regulation of serotonin and dopamine transporters (SERT and DAT). Serotonin 80-89 opioid receptor kappa 1 Homo sapiens 40-43 12874224-5 2003 Accordingly, the mutated HLA-G transfectants were less effective in the inhibition of NK killing and RBL/LIR-1 induced serotonin release. Serotonin 119-128 leukocyte immunoglobulin like receptor B1 Homo sapiens 105-110 10668104-1 1999 Our previous studies indicating that the function of excitatory amino acids, NMDA type receptor, is modulated by serotonin focused on the interaction between serotonin 5HT1B/1D and glutamate, NMDA receptor in brain cortex. Serotonin 113-122 5-hydroxytryptamine receptor 1B Rattus norvegicus 168-173 10668104-1 1999 Our previous studies indicating that the function of excitatory amino acids, NMDA type receptor, is modulated by serotonin focused on the interaction between serotonin 5HT1B/1D and glutamate, NMDA receptor in brain cortex. Serotonin 158-167 5-hydroxytryptamine receptor 1B Rattus norvegicus 168-173 2557964-0 1989 Regulation of alpha-melanocyte-stimulating hormone release from superfused slices of rat hypothalamus by serotonin and the interaction of serotonin with the dopaminergic system inhibiting peptide release. Serotonin 105-114 proopiomelanocortin Rattus norvegicus 14-50 10421712-4 1999 Previously, we reported that serotonin (5-HT) synthesis inhibition by parachlorophenylalanine increases 5-HT(1B) binding site labeling in the SCN. Serotonin 29-38 5-hydroxytryptamine receptor 1B Rattus norvegicus 104-111 12761825-5 2003 LYAAT-1-IR (immunoreactivity) levels varied among different neuroanatomical structures but were present in neurons independently of the neurotransmitter used (glutamate, GABA, acetylcholine, noradrenaline, serotonin, or glycine). Serotonin 206-215 solute carrier family 36 member 1 Rattus norvegicus 0-7 10530928-12 1999 In the serotonin 5-HT1A receptor model, the benzamide phenyl rings of both enantiomers were involved in hydrophobic face-to-face interactions with Phe112 in TM3, while their protonated nitrogen atoms formed a reinforced electrostatic interaction with Asp116 in TM3. Serotonin 7-16 tropomyosin 3 Homo sapiens 157-160 12738797-6 2003 Serotonin binding to 5-HT2B-receptor activates ERK kinases to inhibit Bax expression induced by serum deprivation. Serotonin 0-9 BCL2-associated X protein Mus musculus 70-73 2479300-7 1989 When dinitrophenylated bovine serum albumin (DNP-BSA) as a model allergen was added to RBL-1 cells sensitized with anti-DNP IgE, the peak current decreased because of the degranulation of RBL-1 cells leading to serotonin release. Serotonin 211-220 RB transcriptional corepressor like 1 Rattus norvegicus 188-193 12957218-1 2003 Serotonergic neurons in the dorsal raphe nucleus, the major source of forebrain serotonin projections, synthesize a terminal autoreceptor that inhibits serotonin release-the 5-HT(1B) autoreceptor. Serotonin 80-89 5-hydroxytryptamine receptor 1B Rattus norvegicus 174-181 10530928-12 1999 In the serotonin 5-HT1A receptor model, the benzamide phenyl rings of both enantiomers were involved in hydrophobic face-to-face interactions with Phe112 in TM3, while their protonated nitrogen atoms formed a reinforced electrostatic interaction with Asp116 in TM3. Serotonin 7-16 tropomyosin 3 Homo sapiens 261-264 2505676-1 1989 Incubation of rabbit platelets with thrombin resulted in rapid accumulations of inositol trisphosphate (IP3) in [3H]inositol-labeled platelets, increases of [3H]arachidonic acid [( 3H]AA) release, and [3H]serotonin secretion from the platelets prelabeled with these labeled compounds. Serotonin 205-214 prothrombin Oryctolagus cuniculus 36-44 10454495-10 1999 These observations suggested that serotonergic nerves or other cell types in the saphenous vein are activated by field stimulation to release serotonin, which in turn activates presynaptic 5-HT(1A) receptors on adrenergic neurons to effect norepinephrine release. Serotonin 142-151 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 189-196 12957218-1 2003 Serotonergic neurons in the dorsal raphe nucleus, the major source of forebrain serotonin projections, synthesize a terminal autoreceptor that inhibits serotonin release-the 5-HT(1B) autoreceptor. Serotonin 152-161 5-hydroxytryptamine receptor 1B Rattus norvegicus 174-181 2795467-7 1989 These and previous findings suggest that activation of NK-2 and NK-3 receptors in the midbrain raphe leads to behavioral arousal through their influence on serotonin neurons. Serotonin 156-165 NK3 homeobox 1 Homo sapiens 64-68 12771001-6 2003 At baseline, ABCA1 heterozygotes had decreased HDL levels (0.4+/-0.2 mmol/L; P<0.05), and their forearm blood flow responses to both 5HT (maximum, 49.0+/-10.4%) and L-NMMA (maximum, -22.8+/-22.9%) were blunted compared with control subjects (both P< or =0.005). Serotonin 136-139 ATP binding cassette subfamily A member 1 Homo sapiens 13-18 12771001-7 2003 Infusion of apoA-I/PC disks increased plasma HDL to 1.3+/-0.4 mmol/L in ABCA1 heterozygotes, which resulted in complete restoration of vasomotor responses to both 5HT and L-NMMA (both P</=0.001). Serotonin 163-166 ATP binding cassette subfamily A member 1 Homo sapiens 72-77 10455264-1 1999 The effects of various phorbol-based protein kinase C (PKC) activators on the electrical stimulation-induced (S-I) release of serotonin and acetylcholine was studied in rat brain cortical slices pre-incubated with [3H]-serotonin or [3H]-choline to investigate possible structure-activity relationships. Serotonin 126-135 protein kinase C, alpha Rattus norvegicus 55-58 2753136-0 1989 Histamine and serotonin inhibit induction of ornithine decarboxylase by ornithine in perifused Ehrlich ascites tumour cells. Serotonin 14-23 ornithine decarboxylase, structural 1 Mus musculus 45-68 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 116-125 aralkylamine N-acetyltransferase Homo sapiens 176-210 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 116-125 bromodomain containing 2 Homo sapiens 212-215 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 116-125 acetylserotonin O-methyltransferase Homo sapiens 221-254 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 116-125 acetylserotonin O-methyltransferase Homo sapiens 256-261 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 127-146 aralkylamine N-acetyltransferase Homo sapiens 176-210 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 127-146 bromodomain containing 2 Homo sapiens 212-215 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 127-146 acetylserotonin O-methyltransferase Homo sapiens 221-254 10350570-1 1999 In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Serotonin 127-146 acetylserotonin O-methyltransferase Homo sapiens 256-261 10338362-4 1999 These findings strongly suggest that the human ovary, like the pineal gland, may synthesize melatonin from serotonin by the sequential action of NAT and HIOMT. Serotonin 107-116 bromodomain containing 2 Homo sapiens 145-148 10338362-4 1999 These findings strongly suggest that the human ovary, like the pineal gland, may synthesize melatonin from serotonin by the sequential action of NAT and HIOMT. Serotonin 107-116 acetylserotonin O-methyltransferase Homo sapiens 153-158 12700426-17 2003 There was a slight increase in striatal levels of the serotonin metabolite 5-hydroxyindole acetic acid at all times after treatment with CS2. Serotonin 54-63 calsyntenin 2 Rattus norvegicus 137-140 12606631-5 2003 The beta(2)-selective agonist clenbuterol (0.3 mg/kg) induced increases in brain tryptophan that reached a peak ( approximately 60%) 1 h following injection and small but statistically significant increases ( approximately 20%) in 5-hydroxyindoleacetic acid: serotonin ratios 2 h following injection. Serotonin 259-268 hemoglobin, beta adult minor chain Mus musculus 4-10 12594062-6 2003 The mechanism for IL-16 production was shown to be caspase-3-dependent, and serotonin-induced secretion of IL-16 required binding of the serotonin type 2 receptor. Serotonin 76-85 interleukin 16 Mus musculus 107-112 12594062-7 2003 The relevance of the priming effect associated with sensitization for IL-16 production and storage was confirmed in vivo by serotonin airway challenge of OVA-sensitized mice, resulting in rapid secretion of IL-16 into BAL fluid. Serotonin 124-133 interleukin 16 Mus musculus 70-75 12594062-7 2003 The relevance of the priming effect associated with sensitization for IL-16 production and storage was confirmed in vivo by serotonin airway challenge of OVA-sensitized mice, resulting in rapid secretion of IL-16 into BAL fluid. Serotonin 124-133 interleukin 16 Mus musculus 207-212 12754847-0 2003 [Immunization of rats with bovine serum albumin conjugate with dopamine or 5-hydroxytryptamine prevents the development of experimental MPTP-induced depressive syndrome. Serotonin 75-94 albumin Rattus norvegicus 34-47 2569698-3 1989 During the perioperative period, treatment with somatostatin, thanks to the ease of administration of the drug and the reductive action of gastroenteric secretion, demonstrated its usefulness in countering the action of serotonin. Serotonin 220-229 somatostatin Homo sapiens 48-60 12754847-2 2003 In electrophysiological experiments in Wistar rats it was shown that preventive immunization of animals with bovine serum albumin conjugated with dopamine or 5-hydroxytryptamine or with bovine serum albumin alone partly protects against the development of experimental MPTP-induced depressive syndrome. Serotonin 158-177 albumin Rattus norvegicus 116-129 12809693-9 2003 In serotonin-lesioned rats, the significant increases in full-length BDNF, exon I and exon II mRNA levels were sustained without alteration (with the exception of exon IV in the cornus ammonis subregion 4, CA4). Serotonin 3-12 brain-derived neurotrophic factor Rattus norvegicus 69-73 12617810-12 2002 The co-expression of tphD1, tphD2 and 5-HT in the zebrafish diencephalon appears in striking contrast to the situation in mammals, where diencephalic serotonin results from re-uptake rather than from local production. Serotonin 150-159 tryptophan hydroxylase 1b Danio rerio 28-33 10319816-1 1999 Serotonin N-acetyltransferase, a member of the GNAT acetyltransferase superfamily, is the penultimate enzyme in the conversion of serotonin to melatonin, the circadian neurohormone. Serotonin 130-139 aralkylamine N-acetyltransferase Homo sapiens 0-29 10198381-7 1999 In contrast, dilation of arteries in response to serotonin from apoE -/- and apoE + LDLR -/- mice was impaired compared with normal. Serotonin 49-58 low density lipoprotein receptor Mus musculus 84-88 10323592-2 1999 The involvement of phospholipase D (PLD) in the 5-hydroxytryptamine 5-HT1B/5-HT1D-signalling pathway was assessed in the rabbit isolated mesenteric artery. Serotonin 48-67 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 68-74 12502025-1 2002 Detection of two biogenic amine neurotransmitters, serotonin (5-HT) and norepinephrine (NE) within the CA1 region of the hippocampus (HPC) of behaving male laboratory animals (Rattus norvegicus), was performed with miniature carbon sensors (BRODERICK PROBES) and in vivo semidifferential microvoltammetry after acute administration of the soluble immune factor, human recombinant, interleukin (IL) 1alpha (10 and 100 ng/kg i.p.). Serotonin 51-60 carbonic anhydrase 1 Homo sapiens 103-106 2548882-0 1989 Serotonin raises the cyclic GMP level in a neuronal cell line via 5-HT3 receptors. Serotonin 0-9 5'-nucleotidase, cytosolic II Homo sapiens 28-31 12411459-3 2002 After chronic administration of the Gq agonists phenylephrine, serotonin, and angiotensin II, we observed an attenuation of mean arterial blood pressure and an inhibition of cardiac hypertrophy in the transgenic mice with vascular-specific GqI expression. Serotonin 63-72 guanine nucleotide binding protein, alpha q polypeptide Mus musculus 240-243 12491807-1 2002 Following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, NET, DAT, and SERT, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, VMAT. Serotonin 98-107 solute carrier family 6 member 3 Homo sapiens 180-183 10780831-1 1999 Behavioural and neurochemical evidence indicates a facilitatory effect of 5-hydroxytryptamine (5-HT), acting via 5-HT1B receptors, on dopamine (DA) systems. Serotonin 74-93 5-hydroxytryptamine receptor 1B Rattus norvegicus 113-119 10780831-1 1999 Behavioural and neurochemical evidence indicates a facilitatory effect of 5-hydroxytryptamine (5-HT), acting via 5-HT1B receptors, on dopamine (DA) systems. Serotonin 95-99 5-hydroxytryptamine receptor 1B Rattus norvegicus 113-119 12391293-4 2002 Functional experiments in human and rat show that inhibitors of Src (Lavendustin A, PP2) but not inactive compounds (Lavendustin B, PP3) induce a pronounced relaxation of coronary or aortic smooth muscle precontracted with 5-hydroxytriptamine, phenylephrine, or Angiotensin II. Serotonin 223-242 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 64-67 12354109-0 2002 Proteasome-driven turnover of tryptophan hydroxylase is triggered by phosphorylation in RBL2H3 cells, a serotonin producing mast cell line. Serotonin 104-113 tryptophan hydroxylase 1 Rattus norvegicus 30-52 10089382-1 1999 DOPA decarboxylase is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3, 4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. Serotonin 94-103 dopa decarboxylase Sus scrofa 0-18 2548882-1 1989 Serotonin (5-HT) induced a transient rise of the cyclic GMP level in neuroblastoma X glioma hybrid cells, half-maximally at 1 microM 5-HT. Serotonin 0-9 5'-nucleotidase, cytosolic II Homo sapiens 56-59 2548883-0 1989 Memantine inhibits serotonin-induced rise of cytosolic Ca2+ activity and of cyclic GMP level in a neuronal cell line. Serotonin 19-28 5'-nucleotidase, cytosolic II Homo sapiens 83-86 10219109-1 1999 The present study was undertaken to investigate the effects of extracellular pH (pHe) and intracellular pH (pHi) on 5-hydroxytryptamine (5-HT)-induced contraction and Ca2+ mobilization in vascular smooth muscles. Serotonin 116-135 glucose-6-phosphate isomerase Oryctolagus cuniculus 108-111 10219109-1 1999 The present study was undertaken to investigate the effects of extracellular pH (pHe) and intracellular pH (pHi) on 5-hydroxytryptamine (5-HT)-induced contraction and Ca2+ mobilization in vascular smooth muscles. Serotonin 137-141 glucose-6-phosphate isomerase Oryctolagus cuniculus 108-111 12231467-0 2002 Effect of a 5-HT(2C) serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs. Serotonin 21-30 5-hydroxytryptamine receptor 2C Cavia porcellus 12-19 2548883-1 1989 Serotonin (5-HT) evoked a rise of cytosolic Ca2+ activity in neuroblastoma X glioma hybrid cells, most probably due to the entry of extracellular Ca2+; cyclic GMP synthesis was also stimulated. Serotonin 0-9 5'-nucleotidase, cytosolic II Homo sapiens 159-162 2548883-1 1989 Serotonin (5-HT) evoked a rise of cytosolic Ca2+ activity in neuroblastoma X glioma hybrid cells, most probably due to the entry of extracellular Ca2+; cyclic GMP synthesis was also stimulated. Serotonin 11-15 5'-nucleotidase, cytosolic II Homo sapiens 159-162 12231491-6 2002 In sensitized and challenged CCSP-NGF-tg mice, early-phase reaction, airway inflammation, as well as percental relative increases in serotonin levels were augmented compared with wild-type mice. Serotonin 133-142 secretoglobin, family 1A, member 1 (uteroglobin) Mus musculus 29-33 2471032-3 1989 We examined the effects of activators and an inhibitor of protein kinase C (PKC) on responses to serotonin (5-HT), acetylcholine (ACh), kainate, and gamma-aminobutyric acid (GABA) in oocytes injected with RNA from rat brain. Serotonin 97-106 protein kinase C, gamma Rattus norvegicus 58-74 12231491-6 2002 In sensitized and challenged CCSP-NGF-tg mice, early-phase reaction, airway inflammation, as well as percental relative increases in serotonin levels were augmented compared with wild-type mice. Serotonin 133-142 nerve growth factor Mus musculus 34-37 12196560-4 2002 In 5-HT3A-expressing VIP/CCK interneurons, serotonin induced fast membrane potential depolarizations by activating an inward current that was blocked by the selective 5-HT3R antagonist tropisetron. Serotonin 43-52 cholecystokinin Rattus norvegicus 25-28 10721131-2 1999 The role of tyrosinase and peroxidase in melanogenesis of 5-hydroxytryptamine, 5,6- and 5,7-dihydroxytryptamines was investigated by matrix-assisted laser desorption/ionization mass spectrometry. Serotonin 58-77 tyrosinase Homo sapiens 12-22 10634350-7 1999 Medications with dual effects--blocking reuptake of both serotonin and norepinephrine (e.g., clomipramine and venlafaxine XR)--have superior benefits in achieving remission in major depression and GAD. Serotonin 57-66 glutamate decarboxylase 1 Homo sapiens 197-200 2471032-3 1989 We examined the effects of activators and an inhibitor of protein kinase C (PKC) on responses to serotonin (5-HT), acetylcholine (ACh), kainate, and gamma-aminobutyric acid (GABA) in oocytes injected with RNA from rat brain. Serotonin 97-106 protein kinase C, gamma Rattus norvegicus 76-79 2919672-11 1989 The present study suggests that PAF initially acts directly on smooth muscle and through histamine and serotonin release with a secondary motility response due to activation of nonadrenergic noncholinergic, neuronal activity. Serotonin 103-112 PCNA clamp associated factor Rattus norvegicus 32-35 10408610-0 1999 Central serotonin depletion modulates the behavioural, endocrine and physiological responses to repeated social stress and subsequent c-fos expression in the brains of male rats. Serotonin 8-17 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 134-139 12124378-3 2002 This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters. Serotonin 220-229 small nuclear ribonucleoprotein polypeptide A S homeolog Xenopus laevis 134-137 12124378-3 2002 This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters. Serotonin 220-229 solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog Xenopus laevis 248-251 12124378-3 2002 This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters. Serotonin 231-235 small nuclear ribonucleoprotein polypeptide A S homeolog Xenopus laevis 134-137 12124378-3 2002 This tyrosine residue is conserved within the third transmembrane domain in members of the Na(+):neurotransmitter transporter family (SNF), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (SERT), dopamine (DAT) and norepinephrine (NET) transporters. Serotonin 231-235 solute carrier family 6 (neurotransmitter transporter), member 3 S homeolog Xenopus laevis 248-251 2494988-2 1989 The production of PAF is concentration- and time-dependent and, based upon [3H]serotonin release assays, approx. Serotonin 79-88 PCNA clamp associated factor Rattus norvegicus 18-21 9973692-0 1999 Effect of endothelin-1 on the serotonin-induced contraction of smooth muscle in the guinea pig trachea. Serotonin 30-39 endothelin-1 Cavia porcellus 10-22 9928240-0 1998 Mouse 5-HT2B receptor-mediated serotonin trophic functions. Serotonin 31-40 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 6-12 9928240-6 1998 Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT2B receptors. Serotonin 7-16 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 88-94 9928240-6 1998 Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT2B receptors. Serotonin 40-49 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 88-94 2491757-1 1989 The effects of age on the activity and translocation of protein kinase C (PKC) and on the facilitation of 5-hydroxytryptamine (5-HT, serotonin) release induced by PKC activation with the phorbol ester phorbol 12-myristate 13-acetate were investigated. Serotonin 127-131 protein kinase C, gamma Rattus norvegicus 163-166 12422559-9 2002 Indirect activation of neurotransmitter receptors by antidepressants may also lead, via increases in endogenous levels of serotonin in synapses in specific brain regions, to activation of various G proteins coupled to a receptor, signal of transduction, transcription factors and neurotrophic factors such as brain-derived neurotrophic factor (BDNF). Serotonin 122-131 brain derived neurotrophic factor Homo sapiens 309-342 12422559-9 2002 Indirect activation of neurotransmitter receptors by antidepressants may also lead, via increases in endogenous levels of serotonin in synapses in specific brain regions, to activation of various G proteins coupled to a receptor, signal of transduction, transcription factors and neurotrophic factors such as brain-derived neurotrophic factor (BDNF). Serotonin 122-131 brain derived neurotrophic factor Homo sapiens 344-348 9739147-0 1998 Serotonin 5-HT2c agonists mimic the effect of light pulses on circadian rhythms. Serotonin 0-9 5-hydroxytryptamine receptor 2C Rattus norvegicus 10-16 9739147-1 1998 The serotonin agonist quipazine has been shown to cause phase shifts in melatonin and activity rhythms and to induce c-fos in the suprachiasmatic nucleus of rats. Serotonin 4-13 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 117-122 9739147-6 1998 At a dose of 0.07 micromole/kg, the serotonin antagonist, ritanserin inhibited the DOI induced phase delay whereas ketanserin was ineffective at this dose, providing strong evidence that DOI was acting through 5-HT2c receptors. Serotonin 36-45 5-hydroxytryptamine receptor 2C Rattus norvegicus 210-216 9639277-0 1998 Apposition of enkephalin- and neurotensin-immunoreactive neurons by serotonin-immunoreactive varicosities in the rat spinal cord. Serotonin 68-77 neurotensin Rattus norvegicus 30-41 2491757-1 1989 The effects of age on the activity and translocation of protein kinase C (PKC) and on the facilitation of 5-hydroxytryptamine (5-HT, serotonin) release induced by PKC activation with the phorbol ester phorbol 12-myristate 13-acetate were investigated. Serotonin 133-142 protein kinase C, gamma Rattus norvegicus 163-166 9639277-4 1998 Using a double immunofluorescence technique, serotonin-immunoreactive varicosities were observed to abut the soma or proximal dendrites of [Met]enkephalin- and neurotensin-immunoreactive neurons. Serotonin 45-54 neurotensin Rattus norvegicus 160-171 9639277-5 1998 Nearly 75% of all [Met]enkephalin- and neurotensin-immunoreactive neurons were apposed by serotonin-immunoreactive varicosities in the marginal zone and dorsal gray commissure. Serotonin 90-99 neurotensin Rattus norvegicus 39-50 12031545-1 2002 This study examined the influence of brain-derived neurotrophic factor (BDNF) on the basal and depolarisation-induced release of the neurotransmitters GABA, dopamine and serotonin from rat striatal brain slices in vitro. Serotonin 170-179 brain-derived neurotrophic factor Rattus norvegicus 72-76 12031545-2 2002 BDNF potentiated the potassium or veratrine-stimulated release of GABA, dopamine and serotonin. Serotonin 85-94 brain-derived neurotrophic factor Rattus norvegicus 0-4 9639277-9 1998 The mode of action of spinal serotonin on enkephalin and neurotensin neurons may be through "volume" transmission vs synaptic or "wiring" transmission. Serotonin 29-38 neurotensin Rattus norvegicus 57-68 3401632-10 1988 The hypoactivity induced by mCPP was opposed by three antagonists with high affinity for the 5-hydroxytryptamine (5-HT1C) site; metergoline, mianserin, cyproheptadine and possibly also by a fourth antagonist mesulergine. Serotonin 93-112 5-hydroxytryptamine receptor 2C Rattus norvegicus 114-120 9630494-9 1998 It appears that ovarian steroids may play a crucial role in the regulation of VMAT2 gene expression in the dopamine and serotonin systems. Serotonin 120-129 solute carrier family 18 member A2 Rattus norvegicus 78-83 12077195-7 2002 This study reveals the following: (1) expression of trkB, BDNF, and NT-4 are not modulated by an excess of serotonin during barrel formation, (2) TrkB signaling limits branching of TCAs in inappropriate supragranular cortical layers, and (3) serotonin and TrkB signaling act together to cluster thalamocortical axons in layer IV. Serotonin 242-251 neurotrophic tyrosine kinase, receptor, type 2 Mus musculus 146-150 2845440-3 1988 In Experiment 1, quipazine (serotonin type II agonist) was found to significantly attenuate the short-term effect of MSH while only partially attenuating the long-term action of MSH. Serotonin 28-37 proopiomelanocortin Rattus norvegicus 117-120 9673827-11 1998 5-Hydroxytryptamine regulates serotonergic neuronal activity of the caudal raphe by decreasing spontaneous activity via somatodendritic 5-HT1A receptors and by inhibiting excitatory synaptic transmission onto these neurons via presynaptic 5-HT1B receptors. Serotonin 0-19 5-hydroxytryptamine receptor 1B Rattus norvegicus 239-245 3057797-5 1988 A dense innervation by varicose serotonin fibers was found in the stratum lacunosum-moleculare, but a few serotonin fibers were also distributed in the stratum lucidum of the CA2 and CA3 fields. Serotonin 106-115 carbonic anhydrase 2 Homo sapiens 175-178 9603221-0 1998 Distinct effects of imipramine on 5-hydroxytryptamine uptake mediated by the recombinant rat serotonin transporter SERT1. Serotonin 34-53 Sertoli cell protein 1 Rattus norvegicus 115-120 9578395-4 1998 Serotonin transporter, a plasma membrane protein located on serotonin neurons, regulates the amount of serotonin available for neurotransmission by re-accumulating released serotonin into presynaptic neurons; expression of Fos in the suprachiasmatic nucleus identifies light-activated cells involved in photic resetting of circadian clock phase. Serotonin 103-112 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 223-226 12007749-1 2002 Receptors of the 5-HT2C subtype are assumed to be involved in the influence of serotonin on food intake. Serotonin 79-88 5-hydroxytryptamine receptor 2C Homo sapiens 17-23 3427094-6 1987 The inhibition by thyroid hormones may have implications for regulation of ADH catalysis of ethanol and alcohols in the intermediary metabolism of dopamine, norepinephrine, and serotonin and in steroid metabolism. Serotonin 177-186 aldo-keto reductase family 1 member A1 Homo sapiens 75-78 11939620-8 2002 Pyruvate also blocked insulin"s inhibition of serotonin-induced contraction in nonproliferated cells. Serotonin 46-55 insulin Canis lupus familiaris 22-29 9668668-4 1998 We confirmed this possibility by observing that both tryptophan hydroxylase (the synthesizing enzyme for serotonin) and the DA transporter, proteins particularly susceptible to oxidative modification, were rapidly (within 30 min), but reversibly (returned to control levels by 36 hr) inactivated by a single administration of METH. Serotonin 105-114 solute carrier family 6 member 3 Homo sapiens 124-138 3429143-0 1987 The indium-113m-transferrin complex as an indicator of serotonin-induced vascular changes in the golden hamster lung. Serotonin 55-64 serotransferrin Mesocricetus auratus 16-27 9526020-5 1998 The alpha2C-AR-altered mice appear grossly normal, but subtle changes have been observed in their brain dopamine (DA) and serotonin (5-HT) metabolism. Serotonin 122-131 adrenergic receptor, alpha 2c Mus musculus 4-14 9526020-5 1998 The alpha2C-AR-altered mice appear grossly normal, but subtle changes have been observed in their brain dopamine (DA) and serotonin (5-HT) metabolism. Serotonin 133-137 adrenergic receptor, alpha 2c Mus musculus 4-14 11852032-0 2002 Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus. Serotonin 100-109 glucagon Rattus norvegicus 48-71 3662697-0 1987 Effects of RU 24969 on serotonin release in rat brain cortex: further support for the identity of serotonin autoreceptors with 5-HT1B sites. Serotonin 98-107 5-hydroxytryptamine receptor 1B Rattus norvegicus 127-133 11834300-4 2002 Along with these behavioral findings, the homozygous Fyn-deficient mice showed an increase in extracellular serotonin (5-HT) and dopamine (DA) in the prefrontal cortex and 5-HT in the hippocampus when they were exposed to bright light, while heterozygous and wild-type mice did not show such changes. Serotonin 108-117 Fyn proto-oncogene Mus musculus 53-56 12403357-3 2002 Efficient coligation of PIR-B with FcepsilonRI inhibited IgE-induced mast cell activation and serotonin release. Serotonin 94-103 leukocyte immunoglobulin like receptor B1 Homo sapiens 24-29 9452496-10 1998 Sc5-6 and Sc-ABP3 also prevented the actin severing activity of recombinant full-length scinderin (r-Sc) and inhibited the potentiation by r-Sc of Ca2+-evoked release of serotonin from permeabilized platelets. Serotonin 170-179 scinderin Homo sapiens 88-97 9484853-0 1998 Glutamate release in human cerebral cortex and its modulation by 5-hydroxytryptamine acting at h 5-HT1D receptors. Serotonin 65-84 5-hydroxytryptamine receptor 1D Homo sapiens 97-103 9449433-3 1997 Serotonin and quinolinic acid slightly increased NGF synthesis. Serotonin 0-9 nerve growth factor Mus musculus 49-52 2888915-2 1987 The inhibition was shown to be specific and competitive with PAF on its receptor by the following observations: parallel shift of the dose-response curve; crossing of double reciprocal plots on the intersection of the ordinate; and no inhibition on other autacoids such as bradykinin, histamine, 5-hydroxytryptamine and LTC4. Serotonin 296-315 PCNA clamp associated factor Rattus norvegicus 61-64 9464657-3 1997 Recent findings have shown that intracerebroventricular administration of 5-HT3 or 5-HT1b antagonists decrease both LMA and striatal DA increase suggesting that pressure could enhance the serotonin (5-HT) neurotransmission. Serotonin 188-197 5-hydroxytryptamine receptor 1B Rattus norvegicus 83-89 12095161-1 2002 It has recently been suggested that an increase in brain-derived neurotrophic factor (BDNF) expression may mediate some of the therapeutic effect of antidepressant drugs, via their effects on the neurotransmitter 5-hydroxytryptamine (5-HT). Serotonin 213-232 brain derived neurotrophic factor Homo sapiens 51-84 12095161-1 2002 It has recently been suggested that an increase in brain-derived neurotrophic factor (BDNF) expression may mediate some of the therapeutic effect of antidepressant drugs, via their effects on the neurotransmitter 5-hydroxytryptamine (5-HT). Serotonin 213-232 brain derived neurotrophic factor Homo sapiens 86-90 11801362-8 2002 Homozygous CRH-R1-deficient mice showed enhanced hippocampal levels of 5-hydroxyindoleacetic acid but not of serotonin during the light and the dark phase of the diurnal cycle, which may point to an enhanced synthesis of serotonin in the raphe-hippocampal system. Serotonin 221-230 corticotropin releasing hormone receptor 1 Mus musculus 11-17 11801362-13 2002 These data provide further evidence for the intricate relationship between corticotropin-releasing hormone and serotonin and the important role of the CRH-R1 herein. Serotonin 111-120 corticotropin releasing hormone Mus musculus 75-106 9452197-4 1997 The present study determined whether D-fenfluramine induces the expression of Fos in the brain through the release of serotonin. Serotonin 118-127 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 78-81 3573983-7 1987 Addition of neurotensin (0.001 - 1.0 microM) to the bathing media produced a concentration-dependent increase in dopamine, but not serotonin, release. Serotonin 131-140 neurotensin Rattus norvegicus 12-23 9452197-9 1997 It is likely that D-fenfluramine-induced Fos expression at various sites in the brain is mediated via a combination of serotonin release and other, as yet unidentified, neurotransmitters. Serotonin 119-128 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 41-44 9402050-0 1997 NK1- and NK3-receptor mediated inhibition of 5-hydroxytryptamine release from the vascularly perfused small intestine of the guinea-pig. Serotonin 45-64 neuromedin-K receptor Cavia porcellus 9-21 9503561-12 1997 In rat and primate brain MAO-A is restricted to catecholamine neurons, while MAO-B is largely restricted to serotonin neurons and astrocytes. Serotonin 108-117 monoamine oxidase B Rattus norvegicus 77-82 11734183-1 2001 The stimulation of terminal 5-HT(1B/1D) autoreceptors limits the effects of selective serotonin reuptake inhibitors on extracellular levels of 5-hydroxytryptamine (5-HT, serotonin) in vivo. Serotonin 86-95 5-hydroxytryptamine receptor 1B Rattus norvegicus 28-35 11734183-1 2001 The stimulation of terminal 5-HT(1B/1D) autoreceptors limits the effects of selective serotonin reuptake inhibitors on extracellular levels of 5-hydroxytryptamine (5-HT, serotonin) in vivo. Serotonin 143-162 5-hydroxytryptamine receptor 1B Rattus norvegicus 28-35 11734183-1 2001 The stimulation of terminal 5-HT(1B/1D) autoreceptors limits the effects of selective serotonin reuptake inhibitors on extracellular levels of 5-hydroxytryptamine (5-HT, serotonin) in vivo. Serotonin 170-179 5-hydroxytryptamine receptor 1B Rattus norvegicus 28-35 3495447-11 1987 The data are discussed in the light of the hypothesis that penile erections induction by serotonin-mimetic compounds is mediated by 5HT1B receptors in the striatum. Serotonin 89-98 5-hydroxytryptamine receptor 1B Rattus norvegicus 132-137 11696111-7 2001 Acetylcholine, substance P and serotonin (all at 10(-5) mol L(-1)) induced transient [Ca2+]i changes in subpopulations of myenteric neurones (45.1%, 42.9 and 21.9%, respectively). Serotonin 31-40 carbonic anhydrase 2 Homo sapiens 86-89 9406963-1 1997 The purpose of the present study was to examine the role of 5-hydroxytryptamine (5-HT) neurons in mediating the effects of stress on proopiomelanocortin (POMC) gene expression in the anterior and intermediate lobes of the pituitary gland. Serotonin 60-79 proopiomelanocortin Rattus norvegicus 154-158 2951274-3 1987 Addition of IP3 rapidly induced a dose-related formation of thromboxane B2 and release into the medium, leading to the responses of shape change, aggregation and [14C]5HT release. Serotonin 167-170 immunoglobulin kappa variable 5-2 Homo sapiens 72-86 9361365-1 1997 Inhibition of aggregation by Ro 44-9883, a potent and selective non-peptide GPIIb/IIIa antagonist, resulted in inhibition of serotonin secretion induced by weak agonists such as ADP or low doses of either thrombin receptor agonist peptide (TRAP) or collagen. Serotonin 125-134 integrin subunit alpha 2b Homo sapiens 76-81 9326273-0 1997 The serotonin 5-HT2C receptor is a prominent serotonin receptor in basal ganglia: evidence from functional studies on serotonin-mediated phosphoinositide hydrolysis. Serotonin 4-13 5-hydroxytryptamine receptor 2C Rattus norvegicus 14-20 11594443-0 2001 Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment. Serotonin 16-25 5-hydroxytryptamine receptor 2C Rattus norvegicus 26-32 11764524-0 2001 [Effect of immunizing rats with a serotonin-bovine serum albumin conjugate on the structure of diurnal sleep and electrical activity of the brain]. Serotonin 34-43 albumin Rattus norvegicus 51-64 3815073-2 1987 All 3 sites are solubilized by 3% Triton X-100, 1% Tween-80 and can be enriched by serotonin-linked-Sepharose 4B affinity chromatography. Serotonin 83-92 paired box 5 Homo sapiens 0-5 11764524-1 2001 Rats were immunized with bovine serum albumin conjugated with 5-hydroxytriptamine (5-HT). Serotonin 62-81 albumin Rattus norvegicus 32-45 11764524-1 2001 Rats were immunized with bovine serum albumin conjugated with 5-hydroxytriptamine (5-HT). Serotonin 83-87 albumin Rattus norvegicus 32-45 3815085-1 1987 Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. Serotonin 0-9 5-hydroxytryptamine receptor 2C Rattus norvegicus 97-104 9332732-1 1997 A potential long-term target of glucocorticoid modulation of serotonin (5-HT) production is tryptophan hydroxylase (TPH) gene expression. Serotonin 61-70 tryptophan hydroxylase 1 Rattus norvegicus 92-114 9332732-1 1997 A potential long-term target of glucocorticoid modulation of serotonin (5-HT) production is tryptophan hydroxylase (TPH) gene expression. Serotonin 61-70 tryptophan hydroxylase 1 Rattus norvegicus 116-119 9332732-4 1997 We observed a tissue-specific modulation of TPH mRNA levels in the melatonin producing pineal gland and the serotonin producing raphe nuclei of the brain. Serotonin 108-117 tryptophan hydroxylase 1 Rattus norvegicus 44-47 9332732-10 1997 Hence, glucocorticoids may alter serotonin and melatonin biosynthetic capacity by cell-specific modulation of the TPH gene. Serotonin 33-42 tryptophan hydroxylase 1 Rattus norvegicus 114-117 9239754-4 1997 Thus the B1, B2 and B3 serotonin cell groups all showed high GAP-43 expression in all contained many GAP-43 expressing serotonin cells with spinal cord projections. Serotonin 23-32 B.burgdorferi-associated arthritis 2 Mus musculus 9-21 9239754-4 1997 Thus the B1, B2 and B3 serotonin cell groups all showed high GAP-43 expression in all contained many GAP-43 expressing serotonin cells with spinal cord projections. Serotonin 119-128 B.burgdorferi-associated arthritis 2 Mus musculus 9-21 11445277-1 2001 Effect of caffeine on the expression of tryptophan hydroxylase (TPH), rate limiting enzyme of serotonin synthesis, in dorsal and median raphe was investigated via immunohistochemistry. Serotonin 94-103 tryptophan hydroxylase 1 Rattus norvegicus 40-62 2449619-3 1987 The reduction in 5HT content corresponded to the depression of TPH activity in all regions examined. Serotonin 17-20 tryptophan hydroxylase 1 Rattus norvegicus 63-66 11426759-8 2001 Sarpogrelate inhibited the serotonin-induced increase in intracellular free ionized calcium concentration, prevented mitogen-activated protein kinase activation, and down-regulated expression of the protooncogenes c-fos and c-jun. Serotonin 27-36 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 214-219 11426759-8 2001 Sarpogrelate inhibited the serotonin-induced increase in intracellular free ionized calcium concentration, prevented mitogen-activated protein kinase activation, and down-regulated expression of the protooncogenes c-fos and c-jun. Serotonin 27-36 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 224-229 9276148-1 1997 We have previously reported that neuropeptide Y (NPY) inhibits responses induced by various agonists (noradrenaline, vasoactive intestinal peptide, substance P,5-hydroxytryptamine) in isolated guinea pig trachea. Serotonin 160-179 pro-neuropeptide Y Cavia porcellus 33-47 9276148-1 1997 We have previously reported that neuropeptide Y (NPY) inhibits responses induced by various agonists (noradrenaline, vasoactive intestinal peptide, substance P,5-hydroxytryptamine) in isolated guinea pig trachea. Serotonin 160-179 pro-neuropeptide Y Cavia porcellus 49-52 11441041-4 2001 Evidence for secretion of ADA during blood feeding by Aedes aegypti includes the presence of ADA activity in warm solutions probed through a membrane by mosquitoes and in serotonin-induced saliva and a statistically significant reduction in the levels of the enzyme in Aedes aegypti following a blood meal. Serotonin 171-180 adenosine deaminase-like protein Culex quinquefasciatus 26-29 2436247-5 1987 These dose-dependent reductions are consistent with in vitro biochemical and anatomical data from primate brain suggesting that at low doses of deprenyl, MAO-B inhibition might be expected to selectively affect dopamine and serotonin-containing neurons, while at higher doses (which lead to MAO-A as well as MAO-B inhibition), noradrenergic neurons may become relatively more affected by the drug. Serotonin 224-233 monoamine oxidase B Homo sapiens 154-159 3490854-2 1986 PIR inhibited the 3H-5-hydroxytryptamine (5-HT) uptake in the rat cerebral cortex, not affecting the uptake of 3H-noradrenaline. Serotonin 42-46 pirin Rattus norvegicus 0-3 11513471-0 2001 The effect of serotonin, its precursors and metabolites on brain glutathione-S-transferase. Serotonin 14-23 microsomal glutathione S-transferase 1 Sus scrofa 65-90 11513471-6 2001 Therefore precursors and endogenous derivatives of serotonin but not serotonin itself may affect the detoxification function of brain glutathione-S-transferase and increase the exposure of brain to toxic electrophiles. Serotonin 51-60 microsomal glutathione S-transferase 1 Sus scrofa 134-159 11513471-6 2001 Therefore precursors and endogenous derivatives of serotonin but not serotonin itself may affect the detoxification function of brain glutathione-S-transferase and increase the exposure of brain to toxic electrophiles. Serotonin 69-78 microsomal glutathione S-transferase 1 Sus scrofa 134-159 3467626-5 1986 Concurrent determination of 5HT turnover on the same CSF samples revealed a significant positive correlation between the turnovers of the two transmitters together with considerable inter-individual differences. Serotonin 28-31 colony stimulating factor 2 Rattus norvegicus 53-56 11325593-1 2001 BACKGROUND: Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) catalyzes the first, rate-limiting step in the biosynthesis of the circadian hormone melatonin (5-methoxy-N-acetyltryptamine) from serotonin. Serotonin 217-226 aralkylamine N-acetyltransferase Homo sapiens 12-41 11325593-1 2001 BACKGROUND: Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) catalyzes the first, rate-limiting step in the biosynthesis of the circadian hormone melatonin (5-methoxy-N-acetyltryptamine) from serotonin. Serotonin 217-226 aralkylamine N-acetyltransferase Homo sapiens 43-77 11325593-1 2001 BACKGROUND: Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AANAT) catalyzes the first, rate-limiting step in the biosynthesis of the circadian hormone melatonin (5-methoxy-N-acetyltryptamine) from serotonin. Serotonin 217-226 aralkylamine N-acetyltransferase Homo sapiens 79-84 2936965-0 1986 Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites. Serotonin 35-54 5-hydroxytryptamine receptor 1B Rattus norvegicus 105-111 11330876-0 2001 Angiotensin II and serotonin potentiate endothelin-1-induced vascular smooth muscle cell proliferation. Serotonin 19-28 endothelin-1 Oryctolagus cuniculus 40-52 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 149-168 monoamine oxidase B Homo sapiens 31-36 3005900-8 1986 However, since circulating levels of beta-LPH serve as a marker for anterior lobe (AL) beta-END-LI secretion, serotonin and dopamine appear to exert stimulatory and inhibitory control, respectively, over AL beta-END-LI release. Serotonin 110-119 albumin Rattus norvegicus 204-211 11134050-6 2001 The reciprocal mutant MAO B-Y326I exhibited an increased preference for 5-hydroxytryptamine, a decreased preference for beta-phenylethylamine, and, similar to MAO A, was more sensitive to clorgyline than to deprenyl. Serotonin 72-91 monoamine oxidase B Homo sapiens 22-27 11238275-5 2001 Serotonin-evoked contractions in both groups were inhibited by GR127935 (5-HT(1B/1D) antagonist; 0.1 to 1 nmol/L) and pertussis toxin but not by ketanserin (5-HT(2) antagonist; 0.01 to 1 micromol/L), suggesting that the hypercontraction is most likely mediated by 5-HT(1B/1D) receptors through a pertussis toxin-sensitive pathway. Serotonin 0-9 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 73-80 2942955-8 1986 Furthermore, it is proposed that 5-HT1A receptors mediate inhibitory effects, whereas 5-HT1B receptors mediate presynaptic, facilitatory effects of serotonin. Serotonin 148-157 5-hydroxytryptamine receptor 1B Rattus norvegicus 86-92 11238275-5 2001 Serotonin-evoked contractions in both groups were inhibited by GR127935 (5-HT(1B/1D) antagonist; 0.1 to 1 nmol/L) and pertussis toxin but not by ketanserin (5-HT(2) antagonist; 0.01 to 1 micromol/L), suggesting that the hypercontraction is most likely mediated by 5-HT(1B/1D) receptors through a pertussis toxin-sensitive pathway. Serotonin 0-9 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 264-271 11238275-9 2001 The 5-HT(1B) receptor, which is upregulated by atherosclerosis, most likely mediates the augmenting effects of serotonin. Serotonin 111-120 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 4-11 11168844-13 2001 Together these data suggest (i) that oestrogen decreases expression of GAD67 mRNA in the infundibular region which could lead to decreased GABA synthesis, but addition of progesterone had no further effect and (ii) that GABA neurones in the same region also express mRNA for the stimulatory 5-HT2C receptor which could promote GABA release during serotonin input. Serotonin 347-356 glutamate decarboxylase 1 Homo sapiens 71-76 2415092-5 1985 One of the coelution compounds, observed in DAT but not in control CSF, behaved like a partially oxidized 5-HT. Serotonin 106-110 solute carrier family 6 member 3 Homo sapiens 44-47 11124162-1 2001 We demonstrated previously that atrial natriuretic peptide (ANP) enhances reflex bradycardia to intravenous serotonin [5-hydroxytryptamine (5-HT)] (von Bezold-Jarisch reflex) in rats. Serotonin 108-117 natriuretic peptide A Rattus norvegicus 32-58 11124162-1 2001 We demonstrated previously that atrial natriuretic peptide (ANP) enhances reflex bradycardia to intravenous serotonin [5-hydroxytryptamine (5-HT)] (von Bezold-Jarisch reflex) in rats. Serotonin 108-117 natriuretic peptide A Rattus norvegicus 60-63 11124162-1 2001 We demonstrated previously that atrial natriuretic peptide (ANP) enhances reflex bradycardia to intravenous serotonin [5-hydroxytryptamine (5-HT)] (von Bezold-Jarisch reflex) in rats. Serotonin 119-138 natriuretic peptide A Rattus norvegicus 32-58 11124162-1 2001 We demonstrated previously that atrial natriuretic peptide (ANP) enhances reflex bradycardia to intravenous serotonin [5-hydroxytryptamine (5-HT)] (von Bezold-Jarisch reflex) in rats. Serotonin 119-138 natriuretic peptide A Rattus norvegicus 60-63 2415092-7 1985 Concentrations of 5-HTP, 5-HT, and 5-HIAA were lower in DAT CSF than in a corresponding fraction of control CSF. Serotonin 18-22 solute carrier family 6 member 3 Homo sapiens 56-59 2856724-2 1985 Synthetic ANF caused a relaxation of the renal vessels when these were submaximally activated with noradrenaline or serotonin, but had no effect on the responses of the other vessels to these agonists. Serotonin 116-125 natriuretic peptide A Rattus norvegicus 10-13 11460889-3 2001 The migraine-specific drugs all act as agonists at certain subclasses of serotonin (5-hydroxytryptamine; 5-HT) receptor, particularly those of the 5-HT1D subtype, and produce vasoconstriction through these receptor-mediated mechanisms. Serotonin 73-82 5-hydroxytryptamine receptor 1D Homo sapiens 147-153 11460889-3 2001 The migraine-specific drugs all act as agonists at certain subclasses of serotonin (5-hydroxytryptamine; 5-HT) receptor, particularly those of the 5-HT1D subtype, and produce vasoconstriction through these receptor-mediated mechanisms. Serotonin 84-103 5-hydroxytryptamine receptor 1D Homo sapiens 147-153 2864978-4 1985 These results supply direct evidence for the labeling of a subclass of serotonin receptors, the 5-HT-1B class, providing anatomical and pharmacological basis for some known serotonin-related effects of beta-adrenoceptor drugs. Serotonin 71-80 5-hydroxytryptamine receptor 1B Rattus norvegicus 96-103 11063982-1 2000 Serotonin (5HT) is involved in the development and plasticity of the CNS through the release of S-100beta, a glial trophic factor which stabilizes synapses and neuronal cytoskeleton and promotes neuronal development. Serotonin 0-9 S100 calcium binding protein B Rattus norvegicus 96-105 11063982-1 2000 Serotonin (5HT) is involved in the development and plasticity of the CNS through the release of S-100beta, a glial trophic factor which stabilizes synapses and neuronal cytoskeleton and promotes neuronal development. Serotonin 11-14 S100 calcium binding protein B Rattus norvegicus 96-105 11063982-8 2000 We propose that S-100beta could be accumulated in glial cells during the 5HT depletion period, to be released once 5HT levels have recovered. Serotonin 73-76 S100 calcium binding protein B Rattus norvegicus 16-25 11063982-8 2000 We propose that S-100beta could be accumulated in glial cells during the 5HT depletion period, to be released once 5HT levels have recovered. Serotonin 115-118 S100 calcium binding protein B Rattus norvegicus 16-25 2993947-4 1985 Cholecystokinin appreciably inhibited the circulation of serotonin and dopamine in the brain structures in comparison with physiological saline solution. Serotonin 57-66 cholecystokinin Rattus norvegicus 0-15 2579347-6 1985 Antithrombin III (1.0 unit/ml) relaxed basilar arteries that were precontracted with plasmin (0.5 unit/ml), thrombin (1.0 unit/ml), serotonin (10(-5) M), uridine triphosphate (10(-4) M), or KCl (8 X 10(-2) M). Serotonin 132-141 serpin family C member 1 Canis lupus familiaris 0-16 11032901-0 2000 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo. Serotonin 41-50 5-hydroxytryptamine receptor 1B Rattus norvegicus 0-7 2858863-11 1985 The serotonin effects on protein carboxyl methylation and cyclic GMP could function to stimulate palate reorientation by modulating cell contractility and protein secretion. Serotonin 4-13 5'-nucleotidase, cytosolic II Homo sapiens 65-68 11146399-1 2000 The potential of primary cultures of rabbit renal artery vascular smooth muscle cells (VSMCs) was assessed as a means to investigate the signalling pathways linked to 5-hydroxytryptamine (5-HT) 5-HT(1B)/5-HT(1D) receptors in native arteries. Serotonin 167-186 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 194-201 6548381-1 1984 A novel potential antidepressant, AHR-9377, was evaluated for its inhibition of norepinephrine (NE), serotonin (5-HT) and dopamine (DA) reuptake in hypothalmic, cortical, and striatal rat synaptosomal preparations. Serotonin 101-110 aryl hydrocarbon receptor Rattus norvegicus 34-37 11177291-2 2000 Both catabolism and concentration of 5-hydroxytryptamine increased in the dopaminergic nuclei A11, A10, A9, and in the amygdala. Serotonin 37-56 UDP glucuronosyltransferase 1 family, polypeptide A7C Mus musculus 99-102 6469990-9 1984 These results clearly establish that the pineal gland contains an arylamine N-acetyltransferase and a second, independently regulated arylalkylamine N-acetyltransferase which appears to be primarily responsible for the physiological conversion of serotonin to melatonin via the intermediate N-acetylserotonin. Serotonin 247-256 aralkylamine N-acetyltransferase Homo sapiens 134-168 10940905-7 2000 The physical association between SIRPbeta1 and KARAP/DAP-12 results in the functional coupling of SIRPbeta1 engagement to the recruitment of the protein tyrosine kinase Syk and to serotonin release in RBL cell transfectants. Serotonin 180-189 signal regulatory protein beta 1 Homo sapiens 33-42 10940905-7 2000 The physical association between SIRPbeta1 and KARAP/DAP-12 results in the functional coupling of SIRPbeta1 engagement to the recruitment of the protein tyrosine kinase Syk and to serotonin release in RBL cell transfectants. Serotonin 180-189 signal regulatory protein beta 1 Homo sapiens 98-107 10899966-2 2000 Serotonin (5-HT), a transmitter that regulates the rate of translation in APLYSIA: neurons, had mixed effects on eIF4E phosphorylation. Serotonin 0-9 eukaryotic translation initiation factor 4E Aplysia californica 113-118 6477519-6 1984 In permeabilized platelets, as in the intact cells, release of serotonin was associated with the Ca2+-dependent phosphorylation of 47 000 and 20 000 Da polypeptides (P47 and P20). Serotonin 63-72 tubulin polymerization promoting protein family member 3 Homo sapiens 174-177 10883409-2 2000 The action of 5-hydroxytryptamine (5-HT1B/1D) agonists--so-called triptans--on receptors located in meningeal arteries (5-HT1B) and trigeminovascular fiber endings (5-HT1D) has an inhibitory effect on this neurogenic inflammation. Serotonin 14-33 5-hydroxytryptamine receptor 1D Homo sapiens 165-171 6150515-1 1984 The influence of exogenous serotonin on the secretion of gastric somatostatin and gastrin was investigated under in vitro conditions using an isolated, vascularly perfused rat stomach preparation. Serotonin 27-36 gastrin Rattus norvegicus 82-89 10861803-1 2000 Serotonin release from dorsal raphe projections in the forebrain is regulated by terminal 5-HT(1B) autoreceptors; dysregulation of these receptors may be involved in the pathophysiology of clinical depression. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 90-97 10861803-3 2000 In this study we examined longer term treatment (8 weeks) with several different serotonin-selective reuptake inhibitors (SSRIs) or a tricyclic antidepressant on 5-HT(1B) mRNA regulation in DRN and hippocampus, and evaluated the stability of these drugs" effects after drug discontinuation. Serotonin 81-90 5-hydroxytryptamine receptor 1B Rattus norvegicus 162-169 6150515-2 1984 Serotonin stimulated gastrin release, maximal effects were observed at 10(-6) M which increased gastrin levels by 78%; on the contrary, somatostatin secretion was inhibited (maximal inhibition of 56% at 10(-6) M). Serotonin 0-9 gastrin Rattus norvegicus 21-28 10869889-0 2000 Effects of serotonin and serotonergic agonists and antagonists on the production of interferon-gamma and interleukin-10. Serotonin 11-20 interleukin 10 Homo sapiens 105-119 6150515-2 1984 Serotonin stimulated gastrin release, maximal effects were observed at 10(-6) M which increased gastrin levels by 78%; on the contrary, somatostatin secretion was inhibited (maximal inhibition of 56% at 10(-6) M). Serotonin 0-9 gastrin Rattus norvegicus 96-103 6150515-4 1984 It is concluded that in rats in vitro serotonin inhibits release of gastric somatostatin and stimulates gastrin secretion via specific serotonin receptors but muscarinic cholinergic receptors are also involved. Serotonin 38-47 gastrin Rattus norvegicus 104-111 6748374-3 1984 The selective and potent MAO-A and MAO-B inhibitors FLA 788(+), FLA 336(+), MD 780236 and benzylcyanide caused dose-dependent inhibitions of MAO activity in both carp brain and liver; the inhibition curves were all single-sigmoidal, and the degrees of inhibition of the activities towards 5-hydroxytryptamine (5-HT, selective MAO-A substrate), tyramine (substrate for both forms of MAO) and beta-phenylethylamine (PEA, selective MAO-B substrate) were similar. Serotonin 289-308 monoamine oxidase B Rattus norvegicus 35-40 11021986-0 2000 Effect of corticotropin releasing factor receptor 1 antagonist on extracellular norepinephrine, dopamine and serotonin in hippocampus and prefrontal cortex of rats in vivo. Serotonin 109-118 corticotropin releasing hormone receptor 1 Rattus norvegicus 10-51 10788695-0 2000 Calretinin is present in serotonin- and gamma-aminobutyric acid-positive amacrine cell populations in the retina of Xenopus laevis. Serotonin 25-34 calbindin 2 L homeolog Xenopus laevis 0-10 10788695-2 2000 Double-label immunocytochemistry shows that in the Xenopus retina many calretinin positive amacrine cells are also gamma-aminobutyric acid (GABA)-immunoreactive (IR), none colocalizes glycine or dopamine but some contain serotonin (SER). Serotonin 221-230 calbindin 2 L homeolog Xenopus laevis 71-81 10788695-2 2000 Double-label immunocytochemistry shows that in the Xenopus retina many calretinin positive amacrine cells are also gamma-aminobutyric acid (GABA)-immunoreactive (IR), none colocalizes glycine or dopamine but some contain serotonin (SER). Serotonin 232-235 calbindin 2 L homeolog Xenopus laevis 71-81 10788695-4 2000 Only 4.6% of the CaR-positive cells contain SER. Serotonin 44-47 calbindin 2 L homeolog Xenopus laevis 17-20 10788695-5 2000 The SER-positive cells are present in two sizes in the anuran retina: the large cells never contain CaR but some of the small cells do. Serotonin 4-7 calbindin 2 L homeolog Xenopus laevis 100-103 10788695-8 2000 However, the small SER-synthesizing amacrine cells are invariably CaR-positive. Serotonin 19-22 calbindin 2 L homeolog Xenopus laevis 66-69 10788695-9 2000 Thus the anuran retina contains three neurochemically distinct SER-positive amacrine cell types, one of which (the small SER-synthesizing cell type) is also CaR-IR. Serotonin 121-124 calbindin 2 L homeolog Xenopus laevis 157-160 10800950-1 2000 Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in serotonin biosynthesis. Serotonin 72-81 tryptophan hydroxylase 1 Rattus norvegicus 0-22 10800950-1 2000 Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in serotonin biosynthesis. Serotonin 72-81 tryptophan hydroxylase 1 Rattus norvegicus 24-27 10821328-6 2000 A better understanding of the role played by these and other serotonin receptor subtypes in learning and memory is likely to result from the recent availability of highly specific ligands, such as 5-HT1A, 5-HT1B, 5-HT2A receptor antagonists, and new molecular tools, such as gene knock-out mice, especially inducible mice in which a specific genetic alteration can be restricted both temporally and anatomically. Serotonin 61-70 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 213-228 10737591-8 2000 These results suggest that the mechanism by which d-fenfluramine induces c-fos and jun B expression in the rat caudoputamen depends at least in part on activation of the dopaminergic system by serotonin. Serotonin 193-202 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 73-78 10771023-6 2000 We, as well as others, have shown that the release of the autocrine growth factors 5-hydroxytryptamine (5-HT, serotonin) and mammalian bombesin/gastrin releasing peptide (MB/GRP) by cell lines derived from human small cell lung carcinoma or fetal hamster pulmonary neuroendocrine cells are regulated by a neuronal nicotinic acetylcholine receptor comprised of alpha(7) subunits. Serotonin 83-102 gastrin releasing peptide Homo sapiens 174-177 10771023-6 2000 We, as well as others, have shown that the release of the autocrine growth factors 5-hydroxytryptamine (5-HT, serotonin) and mammalian bombesin/gastrin releasing peptide (MB/GRP) by cell lines derived from human small cell lung carcinoma or fetal hamster pulmonary neuroendocrine cells are regulated by a neuronal nicotinic acetylcholine receptor comprised of alpha(7) subunits. Serotonin 110-119 gastrin releasing peptide Homo sapiens 144-169 10757529-3 2000 Depletion of neocortical serotonin or catecholamine afferents with selective neurotoxins resulted in a permanent alteration of the dendritic arborization of calretinin-containing interneurons, and a transient delay of parvalbumin and calbindin expression in a number of cortical neurones during the second postnatal week. Serotonin 25-34 calbindin 1 Mus musculus 234-243 10694371-8 2000 Furthermore, we show that IA-2 is co-localised with serotonin in carcinoid tumours as well as in the pancreatic tumour cell line, BON1, which is interesting as serotonin secretion rate is presumably higher in tumour cells than in resting EC cells. Serotonin 52-61 protein tyrosine phosphatase receptor type N Homo sapiens 26-30 10694371-8 2000 Furthermore, we show that IA-2 is co-localised with serotonin in carcinoid tumours as well as in the pancreatic tumour cell line, BON1, which is interesting as serotonin secretion rate is presumably higher in tumour cells than in resting EC cells. Serotonin 160-169 protein tyrosine phosphatase receptor type N Homo sapiens 26-30 10791693-7 2000 Surprisingly, serotonin- and/or histamine-containing cells in the connective tissue compartments of the stomach (i.e., lamina propria and submucosa), immunoreactive for a mast cell specific antigen, displayed neither VMATI nor VMAT2 immunoreactivity. Serotonin 14-23 solute carrier family 18 member A2 Rattus norvegicus 227-232 10684976-3 2000 The rat GPR26 cDNA encoded a protein of 317 amino acids, most similar (albeit distantly related) to the serotonin 5-HT(5A) and gastrin releasing hormone BB2 receptors. Serotonin 104-113 G protein-coupled receptor 26 Rattus norvegicus 8-13 10655481-1 2000 The third transmembrane domain (TM3) of serotonin transporter (SERT) contains two isoleucine residues previously proposed to be involved in binding and transport of serotonin. Serotonin 40-49 tropomyosin 3 Homo sapiens 32-35 10618388-0 2000 Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. Serotonin 46-65 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 85-118 11450029-6 2000 These results for the first time suggest that trauma induced release of serotonin and edema formation are important biological signals inducing c-fos expression. Serotonin 72-81 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 144-149 10731674-0 2000 Rapid turnover of tryptophan hydroxylase is driven by proteasomes in RBL2H3 cells, a serotonin producing mast cell line. Serotonin 85-94 tryptophan hydroxylase 1 Rattus norvegicus 18-40 10731674-1 2000 Previously we demonstrated that tryptophan hydroxylase (TPH) undergoes very fast turnover driven by ATP-dependent proteolysis in serotonin producing mast cells [Hasegawa et al. Serotonin 129-138 tryptophan hydroxylase 1 Rattus norvegicus 32-54 10731674-1 2000 Previously we demonstrated that tryptophan hydroxylase (TPH) undergoes very fast turnover driven by ATP-dependent proteolysis in serotonin producing mast cells [Hasegawa et al. Serotonin 129-138 tryptophan hydroxylase 1 Rattus norvegicus 56-59 10670444-9 2000 Most of the Fos-labeled cells co-expressed pro-thyrotropin-releasing hormone messenger RNA signal and/or were serotonin immunoreactive. Serotonin 110-119 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 12-15 10592341-3 1999 We have utilized the polymerase chain reaction (PCR) to directly incorporate a T7 RNA polymerase promoter sequence onto the cDNA for the 5-hydroxytryptamine(1B) (5-HT(1B)) receptor. Serotonin 137-156 5-hydroxytryptamine receptor 1B Rattus norvegicus 162-169 11285147-1 1999 Biogenic amine transporters, namely the dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (serotonin, 5-HT) transporters (DAT, NET and 5-HTT, respectively) appear to be the key elements in regulating biogenic amine neurotransmission. Serotonin 79-98 solute carrier family 6 member 3 Homo sapiens 131-134 10529449-2 1999 This study investigated the effects of the NMDA receptor antagonist, MK-801 on the phase shift of the melatonin rhythm and the induction of c-fos in the rat suprachiasmatic nucleus (SCN) provoked by the administration of the serotonin agonist DOI ((+/-)-1-(4-Iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride). Serotonin 225-234 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 140-145 10504491-3 1999 METHODS: MAOs were characterized in membrane preparations and intact mesangial cells by enzyme assay using [14C]5-hydroxytryptamine and [14C]beta-phenylethylamine as specific substrates for MAO-A and MAO-B, respectively, and by Western blot analysis. Serotonin 112-131 monoamine oxidase B Rattus norvegicus 200-205 10457081-0 1999 Serotonin via 5-HT1B and 5-HT2B receptors stimulates anion secretion in the rat epididymal epithelium. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 14-20 10511460-5 1999 By contrast, BMCMC grown in SCF-containing medium or freshly isolated peritoneal mast cells exhibited significant 3H-hydroxytrypamine (5-HT) release in response to PACAP peptides or VIP. Serotonin 135-139 KIT ligand Homo sapiens 28-31 10421874-8 1999 The present results show evidence that EC cells, mast cells, and nerve cell bodies and fibers in the gastrointestinal tracts of both the human and the rat contain TPH and therefore may have the ability to synthesize serotonin from tryptophan. Serotonin 216-225 tryptophan hydroxylase 1 Rattus norvegicus 163-166 10454462-1 1999 Recently, several novel approaches to the treatment of migraine have been advanced, including selective 5-hydroxytryptamine (or serotonin) 1B/1D (5-HT(1B/1D)) receptor agonists such as sumatriptan and 5-HT(1F) receptor agonists such as LY344864. Serotonin 106-123 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 146-153 10454462-1 1999 Recently, several novel approaches to the treatment of migraine have been advanced, including selective 5-hydroxytryptamine (or serotonin) 1B/1D (5-HT(1B/1D)) receptor agonists such as sumatriptan and 5-HT(1F) receptor agonists such as LY344864. Serotonin 128-137 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 146-153 10507690-5 1999 These results are compatible with previous pharmacological evidence obtained in our laboratory showing that serotonin acting through the 5-HT2c receptor subtype may be important in the phase shifting effects of light on the circadian system. Serotonin 108-117 5-hydroxytryptamine receptor 2C Rattus norvegicus 137-143 10587097-10 1999 Displacement binding of altanserin to cloned serotonin 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 receptors showed Ki values of 0.3, 6.0, 1,756, and 15 nM; the binding of FBP and altanserinol to these four 5-HT subtypes was negligible. Serotonin 45-54 5-hydroxytryptamine receptor 2C Homo sapiens 63-69 10424687-1 1999 Tryptophan hydroxylase (TPH) is the first enzyme in the biosynthetic pathways of melatonin in photoreceptor cells and of serotonin in amacrine cells. Serotonin 121-130 tryptophan hydroxylase 1 L homeolog Xenopus laevis 0-22 10424687-1 1999 Tryptophan hydroxylase (TPH) is the first enzyme in the biosynthetic pathways of melatonin in photoreceptor cells and of serotonin in amacrine cells. Serotonin 121-130 tryptophan hydroxylase 1 L homeolog Xenopus laevis 24-27 10385678-1 1999 The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters. Serotonin 180-199 POU class 2 homeobox 2 Homo sapiens 80-84 10385678-1 1999 The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters. Serotonin 180-199 solute carrier family 22 member 3 Homo sapiens 90-125 10385678-1 1999 The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters. Serotonin 180-199 solute carrier family 22 member 3 Homo sapiens 127-130 10414442-2 1999 The rank order of potency of drugs for the endogenous 5-HT1B receptor was 5-Hydroxytryptamine (5-HT) > zolmitriptan > dihydroergocristine > (-)lisuride (with no response to bromocriptine). Serotonin 74-93 5-hydroxytryptamine receptor 1B Rattus norvegicus 54-60 10364442-1 1999 In the present study we have further studied the previous findings that rat hypothalamic dopaminergic neuronal cell groups may express tryptophan hydroxylase (TpH), the serotonin synthesizing enzyme, without a detectable serotonin synthesis. Serotonin 169-178 tryptophan hydroxylase 1 Rattus norvegicus 135-157 10364442-6 1999 A possible serotonin synthesis by TpH was examined by giving drugs that increase brain serotonin synthesis, but no immunohistochemically detectable serotonin synthesis could be found in any of the TpH expressing neurons. Serotonin 11-20 tryptophan hydroxylase 1 Rattus norvegicus 34-37 10364442-6 1999 A possible serotonin synthesis by TpH was examined by giving drugs that increase brain serotonin synthesis, but no immunohistochemically detectable serotonin synthesis could be found in any of the TpH expressing neurons. Serotonin 87-96 tryptophan hydroxylase 1 Rattus norvegicus 34-37 10349846-0 1999 The endogenous lipid oleamide activates serotonin 5-HT7 neurons in mouse thalamus and hypothalamus. Serotonin 40-49 basigin Mus musculus 52-55 10340628-9 1999 On the basis of these results and previous in vivo measurements of TPH activity (e.g., 5-HT synthesis), we suggest that this upregulation in TPH mRNA expression results from the loss of pre-synaptic and/or post-synaptic regulation of serotonin synthesis. Serotonin 234-243 tryptophan hydroxylase 1 Rattus norvegicus 141-144 10465699-0 1999 5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus. Serotonin 55-64 5-hydroxytryptamine receptor 1B Rattus norvegicus 0-6 10465699-3 1999 In the CA3 region, local application of 5-HT1B antagonists decreased the rate of clearance of the serotonin signal comparably to the selective 5-HT uptake inhibitor (SSRI), fluvoxamine. Serotonin 98-107 5-hydroxytryptamine receptor 1B Rattus norvegicus 40-46 9236722-0 1997 Analysis of [C-11]alpha-methyl-tryptophan kinetics for the estimation of serotonin synthesis rate in vivo. Serotonin 73-82 RNA polymerase III subunit K Homo sapiens 13-17 9236722-1 1997 We describe the tracer kinetic analysis of [C-11]-labeled alpha-methyl-tryptophan (AMT), an analogue of tryptophan, which has been developed as a tracer for serotonin synthesis using positron emission tomography (PET) in human brain. Serotonin 157-166 RNA polymerase III subunit K Homo sapiens 44-48 9236722-9 1997 These results indicate that the Patlak-plot method can be readily applied to [C-11]AMT data in order to create functional images of the K-complex, reflecting serotonin synthesis rate, within an acceptable error margin. Serotonin 158-167 RNA polymerase III subunit K Homo sapiens 78-82 9154322-5 1997 At the "5-HT1B-like" receptor mediating vascular contraction (rabbit saphenous vein), the compound was a potent (p[A50] = 6.79 +/- 0.06) partial agonist achieving 77 +/- 4% of the maximum effect to 5-hydroxytryptamine (5-HT). Serotonin 198-217 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 8-14 9170337-2 1997 The serotonin (5HT1B/D) agonist zolmitriptan (311C90) has been shown to be effective in the treatment of acute attacks of migraine and experimental data suggest that it may have both peripheral and central sites of action. Serotonin 4-13 5-hydroxytryptamine receptor 1B Felis catus 15-20 9096150-10 1997 We suggest that serotonin through the 5-HT3R may regulate GABA and CCK neurotransmission in the telencephalon. Serotonin 16-25 cholecystokinin Rattus norvegicus 67-70 9103201-2 1997 In mast cells stimulated through the FcvarepsilonRI receptor, activation of several PTKs including Syk leads to degranulation and release of such mediators of the allergic response as histamine and serotonin. Serotonin 198-207 spleen associated tyrosine kinase Homo sapiens 99-102 9066990-2 1997 Our hypothesis was that presynaptic 5-hydroxytryptamine1B (5-HT1B) receptors, which inhibit the synthesis and release of serotonin in nerve terminals, may be increased in learned helplessness. Serotonin 121-130 5-hydroxytryptamine receptor 1B Rattus norvegicus 36-57 9066990-2 1997 Our hypothesis was that presynaptic 5-hydroxytryptamine1B (5-HT1B) receptors, which inhibit the synthesis and release of serotonin in nerve terminals, may be increased in learned helplessness. Serotonin 121-130 5-hydroxytryptamine receptor 1B Rattus norvegicus 59-65 9066990-5 1997 The detection of increased 5-HT1B mRNA levels in the dorsal raphe nucleus suggests an increased capacity to synthesize presynaptic 5-HT1B receptors and could account for diminished serotonin neurotransmission in learned helplessness. Serotonin 181-190 5-hydroxytryptamine receptor 1B Rattus norvegicus 27-33 9046014-1 1997 In vivo effects of single and repeated interferon-alpha administrations on the dynamics of noradrenaline, dopamine and 5-hydroxytryptamine were investigated in the mouse brain. Serotonin 119-138 interferon alpha Mus musculus 39-55 9393391-2 1997 It is hypothesized that SRI-refractory patients may have altered serotonin neurotransmission different from patients responsive to SRIs, or that they may have abnormalities in their dopamine function. Serotonin 65-74 sorcin Homo sapiens 24-27 8987145-1 1997 Monoamine oxidases A and B (MAOA and MAOB) are the major catabolic isoenzymes of catecholamines and serotonin in the mammalian brain. Serotonin 100-109 monoamine oxidase B Homo sapiens 37-41 8960551-2 1996 Binding experiments at cloned human 5-HT(1B), 5-HT(1D), and 5-HT(1A) receptors show that all of these dimers are very potent ligands at 5-HT(1B/1D) receptors with increased binding selectivity vs the 5-HT(1A) receptor when compared to serotonin. Serotonin 235-244 5-hydroxytryptamine receptor 1D Homo sapiens 46-53 8954759-2 1996 Serotonin (5-HT) was recently shown to stimulate PRL secretion through VIP. Serotonin 0-9 prolactin Gallus gallus 49-52 8954759-2 1996 Serotonin (5-HT) was recently shown to stimulate PRL secretion through VIP. Serotonin 0-9 vasoactive intestinal peptide Gallus gallus 71-74 8972551-1 1996 CP-135,807 [3-(N-methylpyrrolidin-2R-ylmethyl)-5-(3-nitropyrid-2- yl)amino-1H-indole] binds with high affinity to central 5-HT1D receptors, and in functional studies produces dose-dependent decreases in extracellular serotonin. Serotonin 217-226 5-hydroxytryptamine receptor 1D Homo sapiens 122-128 8913363-1 1996 Serotonin acting on 5-hydroxytryptamine4 receptors increases membrane excitability in CA1 hippocampal pyramidal cells by reducing the slow calcium-activated afterhyperpolarization. Serotonin 0-9 carbonic anhydrase 1 Homo sapiens 86-89 8913363-9 1996 These results indicate that serotonin inhibits the afterhyperpolarization in the CA1 region of hippocampus by reducing the ability of extracellular calcium to trigger calcium release from intracellular stores. Serotonin 28-37 carbonic anhydrase 1 Homo sapiens 81-84 8914125-7 1996 These results suggest that chronic fluoxetine may increase serotonin release from axonal terminals by down-regulating the messenger RNA coding for presynaptic 5-HT1B autoreceptors while causing only transient effects on serotonin transporter mRNA. Serotonin 59-68 5-hydroxytryptamine receptor 1B Rattus norvegicus 159-165 8910861-0 1996 Involvement of prostaglandins and 5-hydroxytryptamine in the contractile effect of platelet-activating factor in rat isolated gastric corpus. Serotonin 34-53 PCNA clamp associated factor Rattus norvegicus 83-109 8910861-6 1996 The present study supports the view that the effect of PAF is mediated by activation of specific PAF receptors and the release of prostaglandins and 5-hydroxytryptamine in isolated gastric corpus. Serotonin 149-168 PCNA clamp associated factor Rattus norvegicus 55-58 8910861-7 1996 Furthermore, our results suggest a role of the gastric mucosa via the release of 5-hydroxytryptamine which contributes to the contractile effect of PAF in the gastric smooth muscle. Serotonin 81-100 PCNA clamp associated factor Rattus norvegicus 148-151 8843032-3 1996 The serotonin-induced enhancement was mimicked by the protein kinase C activators 1-oleoyl-2-acetyl-sn-glycerol (100 microM) and phorbol 12-myristate 13-acetate (10 nM), whereas the inactive phorbol ester 4-alpha-phorbol 12-myristate 13-acetate (10 nM) had no effect. Serotonin 4-13 protein kinase C, gamma Rattus norvegicus 54-70 8843032-5 1996 In agreement with this conclusion, it was found that the serotonin effect was inhibited by the protein kinase C inhibitors sphingosine (1 microM) or staurosporine (1 microM) added 20 min before NMDA application and by oocyte injection of protein kinase C (PKC)-inhibitor peptide (500 ng/oocyte) 1 hr prior to recordings. Serotonin 57-66 protein kinase C, gamma Rattus norvegicus 95-111 8843032-5 1996 In agreement with this conclusion, it was found that the serotonin effect was inhibited by the protein kinase C inhibitors sphingosine (1 microM) or staurosporine (1 microM) added 20 min before NMDA application and by oocyte injection of protein kinase C (PKC)-inhibitor peptide (500 ng/oocyte) 1 hr prior to recordings. Serotonin 57-66 protein kinase C, gamma Rattus norvegicus 238-254 8843032-5 1996 In agreement with this conclusion, it was found that the serotonin effect was inhibited by the protein kinase C inhibitors sphingosine (1 microM) or staurosporine (1 microM) added 20 min before NMDA application and by oocyte injection of protein kinase C (PKC)-inhibitor peptide (500 ng/oocyte) 1 hr prior to recordings. Serotonin 57-66 protein kinase C, gamma Rattus norvegicus 256-259 8767925-6 1996 It is released under basal conditions and in response to mechanical stimuli such as shear stress and in response to receptor-operated agonists such as bradykinin, serotonin, ADP/ATP, thrombin, histamine and substance P. NO is the mediator of endothelium-dependent relaxation in the circulation and exerts its effects by activating soluble guanylyl cyclase in vascular smooth muscle, which in turn leads to the formation of cyclic guanosine monophosphate (cyclic GMP) and to relaxation. Serotonin 163-172 5'-nucleotidase, cytosolic II Homo sapiens 462-465 8661026-6 1996 Brain and pituitary AA-NAT could modulate serotonin-dependent aspects of human behavior and pituitary function. Serotonin 42-51 aralkylamine N-acetyltransferase Homo sapiens 20-26 8627564-0 1996 Endogenous serotonin facilitates in vivo acetylcholine release in rat frontal cortex through 5-HT 1B receptors. Serotonin 11-20 5-hydroxytryptamine receptor 1B Rattus norvegicus 93-100 8731458-7 1996 These findings suggest that exaggerated increases in [Ca++]i in response to serotonin are a characteristic of depressed patients not shared with schizophrenic and substance abuse patients. Serotonin 76-85 carbonic anhydrase 1 Homo sapiens 54-60 8774757-7 1996 These results suggest that BK, PAF, histamine/serotonin and prostaglandins are involved in the LPS-induced increase in vascular permeability, where PAF, in addition to its direct action, potentiates the response to BK and histamine, and prostaglandins potentiate the actions of other mediators without its direct action. Serotonin 46-55 PCNA clamp associated factor Rattus norvegicus 148-151 8814905-1 1996 Previous studies have reported a neuromodulatory effect of brain-derived neurotrophic factor (BDNF) on serotonin neurons in the central nervous system. Serotonin 103-112 brain-derived neurotrophic factor Rattus norvegicus 59-92 8814905-1 1996 Previous studies have reported a neuromodulatory effect of brain-derived neurotrophic factor (BDNF) on serotonin neurons in the central nervous system. Serotonin 103-112 brain-derived neurotrophic factor Rattus norvegicus 94-98 8698885-9 1996 The localization of CYP2D1 in several regions known to harbor catecholamines and serotonin may suggest a role for CYP2D1 in the metabolism of monoamines. Serotonin 81-90 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 20-26 8698885-9 1996 The localization of CYP2D1 in several regions known to harbor catecholamines and serotonin may suggest a role for CYP2D1 in the metabolism of monoamines. Serotonin 81-90 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 114-120 8726104-5 1996 As with the primary neurons, removal and replacement of CNTF with BDNF after 4 days resulted in a partial restitution of 5HT expression. Serotonin 121-124 brain-derived neurotrophic factor Rattus norvegicus 66-70 8678123-1 1996 The monoamine oxidases (MAO-A and MAO-B) are the enzymes primarily responsible for the degradation of amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. Serotonin 165-174 monoamine oxidase B Homo sapiens 34-39 8547642-6 1996 Recombinant scinderin and peptides Sc-ABP1 and Sc-ABP2 were tested for their effects on Ca(2+)-induced serotonin release from digitonin permeabilized platelets. Serotonin 103-112 scinderin Homo sapiens 12-21 8547642-7 1996 The results indicated that recombinant scinderin potentiates Ca(2+)-evoked serotonin release, an effect blocked in the presence of Sc-ABP1, Sc-ABP2, exogenous gamma-actin, or the addition of phosphatidylinositol 4,5-bisphosphate (PIP2). Serotonin 75-84 scinderin Homo sapiens 39-48 8598470-14 1996 These results suggest that C2-ceramide inhibits Ag-induced PLD activation and serotonin release, probably through the blockage of Ca2+ influx and translocation of Ca(2+)-dependent PKC isozymes in RBL-2H3 cells. Serotonin 78-87 protein kinase C, alpha Rattus norvegicus 180-183 8613795-4 1996 Locomoter-like activity was induced by bath-applying a mixture of serotonin and NMDA to segments L1/L2. Serotonin 66-75 ribosomal protein L4 Rattus norvegicus 97-102 9025111-0 1996 Serotonin efflux in the rat ventral lateral geniculate nucleus assessed by fast cyclic voltammetry is modulated by 5-HT1B and 5-HT1D autoreceptors. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 115-121 8788910-14 1995 Our data confirm that cholinergic terminals in the intact hippocampus possess inhibitory muscarinic autoreceptors and serotonin heteroreceptors of the 5-HT1B subtype. Serotonin 118-127 5-hydroxytryptamine receptor 1B Rattus norvegicus 151-157 8538158-2 1995 Although SMS inhibits tumor release of serotonin (5HT) and other bioactive agents, it also inhibits the diarrhea in patients who continue to exhibit elevated serum levels of 5HT. Serotonin 39-48 spermine synthase Homo sapiens 9-12 8538158-2 1995 Although SMS inhibits tumor release of serotonin (5HT) and other bioactive agents, it also inhibits the diarrhea in patients who continue to exhibit elevated serum levels of 5HT. Serotonin 50-53 spermine synthase Homo sapiens 9-12 8538158-2 1995 Although SMS inhibits tumor release of serotonin (5HT) and other bioactive agents, it also inhibits the diarrhea in patients who continue to exhibit elevated serum levels of 5HT. Serotonin 174-177 spermine synthase Homo sapiens 9-12 8544984-1 1995 The immunocytochemical localization of the immediate-early gene c-fos has been used to map sites of neuronal activity in the rat brain associated with 5-hydroxytryptamine function. Serotonin 151-170 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 64-69 8544984-3 1995 We now report that such treatment induces a specific anatomical pattern of expression of c-fos in rat forebrain in many limbic, striatal and cortical areas which corresponds well with the distribution of 5-hydroxytryptamine-immunoreactive terminals. Serotonin 204-223 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 89-94 8544984-7 1995 The results of this study suggest that the elevation in Fos-like immunoreactivity following treatment with tryptophan and a monoamine oxidase inhibitor is mainly due to increased 5-hydroxytryptamine synthesis and release. Serotonin 179-198 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 56-59 8548293-0 1995 Action potential-dependent output of 5-hydroxytryptamine in the anaesthetized rat amygdalopiriform cortex is strongly inhibited by tonic 5-HT1B-receptor stimulation. Serotonin 37-56 5-hydroxytryptamine receptor 1B Rattus norvegicus 137-143 7664446-1 1995 BACKGROUND: Insulin attenuates serotonin-induced Ca2+ influx, the intracellular Ca2+ transient, and contraction of cultured vascular smooth muscle cells from dog femoral artery. Serotonin 31-40 insulin Canis lupus familiaris 12-19 7658447-0 1995 Synthesis and serotonergic activity of arylpiperazide derivatives of serotonin: potent agonists for 5-HT1D receptors. Serotonin 69-78 5-hydroxytryptamine receptor 1D Homo sapiens 100-106 7658447-1 1995 A series of new arylpiperazide derivatives of serotonin has been prepared and evaluated as 5-HT1D receptor agonists. Serotonin 46-55 5-hydroxytryptamine receptor 1D Homo sapiens 91-97 10216194-5 1999 Neural activity was characterized using immunohistochemistry to detect the immediate early gene product Fos in serotonin-immunoreactive cells in the DRN. Serotonin 111-120 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 104-107 10194650-0 1999 Serotonin agonist quipazine induces photic-like phase shifts of the circadian activity rhythm and c-Fos expression in the rat suprachiasmatic nucleus. Serotonin 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 98-103 10188949-3 1999 In the present study, we investigated the relationship of the cloned kappa-opioid receptor to spinally projecting neurons immunoreactive for serotonin or GABA. Serotonin 141-150 opioid receptor kappa 1 Homo sapiens 69-90 10036306-1 1999 Arylalkylamine N-acetyltransferase (AA-NAT, E. C. 2.3.1.87) is the enzyme that catalyzes the transfer of an acetyl group from acetyl-CoA to serotonin to form N-acetylserotonin (NAS) in the indoleamine biosynthetic pathway. Serotonin 140-149 serotonin N-acetyltransferase Bos taurus 0-34 10036306-1 1999 Arylalkylamine N-acetyltransferase (AA-NAT, E. C. 2.3.1.87) is the enzyme that catalyzes the transfer of an acetyl group from acetyl-CoA to serotonin to form N-acetylserotonin (NAS) in the indoleamine biosynthetic pathway. Serotonin 140-149 serotonin N-acetyltransferase Bos taurus 36-42 10079007-16 1999 These results suggest that serotonin, primarily via 5-HT2A receptors, may modulate CCK-mediated gastrointestinal functions in rats. Serotonin 27-36 cholecystokinin Rattus norvegicus 83-86 6320925-0 1984 Effect of polyethyleneglycols (PEG 600 and PEG 6000) and bovine serum albumin on myeloperoxidase-mediated release of [3H]-serotonin from rat peritoneal mast cells in vitro. Serotonin 122-131 albumin Rattus norvegicus 64-77 8561965-1 1995 14.3.3 protein, a brain-specific protein, is an activator of tyrosine and tryptophan hydroxylases, key enzymes for biosynthesis of dopamine and serotonin. Serotonin 144-153 tubulin polymerization promoting protein family member 3 Homo sapiens 18-40 9950921-1 1999 The present study investigated the relationship between endogenous CCK and serotonin (5-HT) in fat-induced satiety. Serotonin 75-84 cholecystokinin Rattus norvegicus 67-70 6227192-8 1983 These results suggest that serotonin stimulates prolactin secretion in chickens by increasing pituitary responsiveness to hypothalamic releasing factors and by increasing the prolactin releasing activity of the hypothalamus. Serotonin 27-36 prolactin Gallus gallus 175-184 7601307-5 1995 5HT synthesis in RN46A cells requires initial treatment with BDNF, followed by growth under partial membrane depolarizing conditions. Serotonin 0-3 brain-derived neurotrophic factor Rattus norvegicus 61-65 6604123-1 1983 C3a liberated from C3 by treatment with C3 convertase (or by trypsin) induced aggregation of gel-filtered human platelets and stimulated serotonin release. Serotonin 137-146 complement C3 Homo sapiens 0-3 7601307-6 1995 Embryonic raphe cultures treated similarly with BDNF and partial depolarizing conditions also demonstrate increased 5HT synthesis. Serotonin 116-119 brain-derived neurotrophic factor Rattus norvegicus 48-52 9890434-0 1999 Serotonin depletion in the adult rat produces differential changes in highly polysialylated form of neural cell adhesion molecule and tenascin-C immunoreactivity. Serotonin 0-9 tenascin C Rattus norvegicus 134-144 6604123-3 1983 However, at lower concentrations (2 X 10(-12) M) C3a did not aggregate platelets directly but exhibited highly significant synergism (two-way analysis of variance P less than 0.0001) with ADP in mediating platelet aggregation and release of serotonin. Serotonin 241-250 complement C3 Homo sapiens 49-52 6849980-7 1983 The [14C]serotonin release induced by sodium arachidonate and thrombin was unaffected. Serotonin 9-18 prothrombin Oryctolagus cuniculus 62-70 10024876-1 1999 Conversion of serotonin to N-acetylserotonin, the precursor of the circadian neurohormone melatonin, is catalyzed by serotonin N-acetyltransferase (AANAT) in a reaction requiring acetyl coenzyme A (AcCoA). Serotonin 14-23 aralkylamine N-acetyltransferase Homo sapiens 117-146 10024876-1 1999 Conversion of serotonin to N-acetylserotonin, the precursor of the circadian neurohormone melatonin, is catalyzed by serotonin N-acetyltransferase (AANAT) in a reaction requiring acetyl coenzyme A (AcCoA). Serotonin 14-23 aralkylamine N-acetyltransferase Homo sapiens 148-153 10897801-4 1999 MAO-A and MAO-B activities were estimated with radioassays employing serotonin and beta-phenylethylamine, respectively and specific inhibitors, clorgyline and deprenyl. Serotonin 69-78 monoamine oxidase B Rattus norvegicus 10-15 10197774-2 1999 At embryonic day 14, saturating concentrations of brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4 and basic fibroblast growth factor elicited a two- to 2.5-fold increase in numbers of tryptophan hydroxylase- and serotonin-immunoreactive neurons over a four-day culture period. Serotonin 230-239 brain-derived neurotrophic factor Rattus norvegicus 50-83 7623124-3 1995 When a mixture of serotonin and N-methyl-D,L-aspartate was bath applied to the upper lumbar cord (L1/L2 segments), rhythmic locomotor-like activity was induced and recorded in all the lumbar segments (from L1 to L5). Serotonin 18-27 ribosomal protein L4 Rattus norvegicus 98-103 8642901-6 1995 The second response on repeated administration of acetylcholine was augmented and that of serotonin attenuated in both GPT and RT. Serotonin 90-99 glutamic--pyruvic transaminase Rattus norvegicus 119-122 6191240-3 1983 The results show that the hypotensive activity of NT and of compound 48/80 (C48/80), in contrast to that of histamine, of 5-hydroxytryptamine and of hexamethonium, is markedly reduced, especially for NT, in nephrectomized as compared to sham operated rats. Serotonin 122-141 neurotensin Rattus norvegicus 50-52 10197774-2 1999 At embryonic day 14, saturating concentrations of brain-derived neurotrophic factor, neurotrophin-3, neurotrophin-4 and basic fibroblast growth factor elicited a two- to 2.5-fold increase in numbers of tryptophan hydroxylase- and serotonin-immunoreactive neurons over a four-day culture period. Serotonin 230-239 neurotrophin 4 Rattus norvegicus 101-115 10197774-9 1999 The ability of cells to specifically take up the serotonin analog 5,7-dihydroxytryptamine was also up-regulated by brain-derived neurotrophic factor in both rostral and caudal raphe cultures. Serotonin 49-58 brain-derived neurotrophic factor Rattus norvegicus 115-148 6191761-1 1983 The biologically active fragment of human parathormone (PTH) and intact bovine PTH were found to induce secretion of both serotonin and histamine from rat peritoneal mast cells in vitro. Serotonin 122-131 parathyroid hormone Bos taurus 79-82 9920348-7 1998 [Ca2+]cyt-tension relationships in the stretch-induced contraction changed counterclockwise as those in the contractions induced by high KC1 and pharmacological agonistic stimulants such as 5-hydroxytryptamine (5-HT) and endothelin-1 (ET-1). Serotonin 190-209 carbonic anhydrase 2 Canis lupus familiaris 1-4 9920348-7 1998 [Ca2+]cyt-tension relationships in the stretch-induced contraction changed counterclockwise as those in the contractions induced by high KC1 and pharmacological agonistic stimulants such as 5-hydroxytryptamine (5-HT) and endothelin-1 (ET-1). Serotonin 211-215 carbonic anhydrase 2 Canis lupus familiaris 1-4 8527368-5 1995 Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the serotonin synthetic pathway, was recently cloned from Xenopus laevis retina, providing a specific probe for localization of serotonin synthesis. Serotonin 62-71 tryptophan hydroxylase 1 L homeolog Xenopus laevis 0-22 8527368-5 1995 Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the serotonin synthetic pathway, was recently cloned from Xenopus laevis retina, providing a specific probe for localization of serotonin synthesis. Serotonin 62-71 tryptophan hydroxylase 1 L homeolog Xenopus laevis 24-27 8527368-5 1995 Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the serotonin synthetic pathway, was recently cloned from Xenopus laevis retina, providing a specific probe for localization of serotonin synthesis. Serotonin 186-195 tryptophan hydroxylase 1 L homeolog Xenopus laevis 0-22 8527368-5 1995 Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the serotonin synthetic pathway, was recently cloned from Xenopus laevis retina, providing a specific probe for localization of serotonin synthesis. Serotonin 186-195 tryptophan hydroxylase 1 L homeolog Xenopus laevis 24-27 7758187-7 1995 In untreated control animals with an ischemic limb, serotonin administered at day 10 or 40 produced a decrease in hindlimb blood flow (71 +/- 2% and 33 +/- 6% reduction from baseline, respectively); in contrast, among animals treated with a single 500-micrograms bolus dose of VEGF administered selectively into the internal iliac artery at day 10 and studied at day 40, serotonin produced an increase in flow (119 +/- 8% from baseline; P < .05 versus control animals). Serotonin 52-61 vascular endothelial growth factor A Oryctolagus cuniculus 277-281 9825023-0 1998 Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer"s disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT. Serotonin 0-9 solute carrier family 6 member 3 Homo sapiens 94-97 6839209-0 1983 Growth hormone stimulates serotonin secretion into the hepatic portal circulation. Serotonin 26-35 somatotropin Canis lupus familiaris 0-14 9825023-0 1998 Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer"s disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT. Serotonin 0-9 solute carrier family 6 member 3 Homo sapiens 202-205 9723944-2 1998 In the human temporal artery both 5-HT1-like and 5-HT2A receptors mediate the contractile effects of 5-hydroxytryptamine (5-HT) and we have suggested that the 5-HT1-like receptors resemble more closely recombinant 5-HT1B than 5-HT1D receptors. Serotonin 101-120 5-hydroxytryptamine receptor 1D Homo sapiens 226-232 7714755-1 1995 In this study, the involvement of serotonergic and dopaminergic receptors in the modulation of the head-twitch (HTW) response to the 5-hydroxytryptamine (5-HT)2A/5-HT2C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, was characterized in rats using novel and selective ligands at 5-HT2A, 5-HT2C, D1, D2 and 5-HT1A receptors. Serotonin 133-152 5-hydroxytryptamine receptor 2C Rattus norvegicus 162-168 7714755-1 1995 In this study, the involvement of serotonergic and dopaminergic receptors in the modulation of the head-twitch (HTW) response to the 5-hydroxytryptamine (5-HT)2A/5-HT2C agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, was characterized in rats using novel and selective ligands at 5-HT2A, 5-HT2C, D1, D2 and 5-HT1A receptors. Serotonin 133-152 5-hydroxytryptamine receptor 2C Rattus norvegicus 296-302 7781701-2 1995 We investigated the effect of the cholinesterase inhibitor, MDL 73,745 (2,2,2-trifluoro-1-(3-trimethylsilylphenyl)ethanone), on the extracellular levels of acetylcholine, norepinephrine, dopamine and 5-hydroxytryptamine in the cerebral cortex of the rat by high-performance liquid chromatography coupled with electrochemical detection. Serotonin 200-219 butyrylcholinesterase Rattus norvegicus 34-48 6839209-1 1983 Hepatic portal plasma concentrations of free serotonin were found to be transiently but significantly elevated in normal dogs following a single injection of ovine growth hormone into a peripheral vein. Serotonin 45-54 somatotropin Canis lupus familiaris 164-178 9716307-6 1998 It is also speculated that serotonin/benzodiazepine interactions existing in the brain may functionally involve the 5HT2C receptor subtypes and that the anxiogenic action reported under certain circumstances for 5HT mimetics are not mediated by 5HT2C receptor subtypes. Serotonin 27-36 5-hydroxytryptamine receptor 2C Rattus norvegicus 116-121 6129770-7 1982 Among a wide range of other CNS active compounds tested, CAR was inhibited by alpha 1-adrenergic antagonists, benzodiazepines, a barbiturate, GABA agonists, morphine and a serotonin agonist, but in doses inducing other motor disturbances. Serotonin 172-181 nuclear receptor subfamily 1, group I, member 3 Rattus norvegicus 57-60 6755469-2 1982 MAO-B is specifically located in two major central nervous system cell classes, astrocytes and serotonin-containing neurons. Serotonin 95-104 monoamine oxidase B Rattus norvegicus 0-5 9671650-7 1998 Application of 5-HT or its agonists 5-carboxamidotryptamine maleate and (+/-)-8-hydroxy-2-(di-n-propyl-amino) tetralin hydrobromide on cells transformed with 5-HTap1 produced a dose-dependent inhibition of forskolin-stimulated cAMP accumulation. Serotonin 15-19 G-protein-coupled 5-hydroxytryptamine receptor Aplysia californica 158-165 9687576-3 1998 In Xenopus laevis oocytes expressing hOCT2, electrogenic transport of norepinephrine, histamine, dopamine, serotonin, and the antiparkinsonian drugs memantine and amantadine was demonstrated by tracer influx, tracer efflux, electrical measurements, or a combination. Serotonin 107-116 POU class 2 homeobox 2 Homo sapiens 37-42 7173435-2 1982 Cholecystokinin suppressing markedly dopamine and serotonin turnover in various brain structures, completely blocked the behavioral effects of amphetamine (2.5 mg/kg) and 5-hydroxytryptophan (150 mg/kg). Serotonin 50-59 cholecystokinin Rattus norvegicus 0-15 9651336-8 1998 Surprisingly, serotonin activation of 5-HT7A stimulated AC1 and AC8 by increasing intracellular Ca2+. Serotonin 14-23 adenylate cyclase 8 Homo sapiens 64-67 9690735-5 1998 The results showed that 1500 nM [3H]ouabain binding was sensitive to serotonin 10(-3) M and significantly increased in the following brain regions: frontal cortex, areas CA1, CA2, and CA3 of the hippocampus, presubiculum, zona incerta, caudate putamen and the amygdaloid area, confirming and extending previous results. Serotonin 69-78 carbonic anhydrase 3 Rattus norvegicus 184-187 6129617-9 1982 Both dopamine and serotonin, however, dose-dependently inhibited the formation of radiolabelled TPI and PA. Serotonin 18-27 triosephosphate isomerase 1 Rattus norvegicus 96-99 9630672-1 1998 Tryptophan hydroxylase (TPH) is the rate limiting enzyme in serotonin biosynthesis [D.G. Serotonin 60-69 tryptophan hydroxylase 1 Rattus norvegicus 0-22 9630672-1 1998 Tryptophan hydroxylase (TPH) is the rate limiting enzyme in serotonin biosynthesis [D.G. Serotonin 60-69 tryptophan hydroxylase 1 Rattus norvegicus 24-27 6179569-5 1982 Before probenecid treatment, comparisons of metabolite concentrations in samples from normal versus narcoleptic dogs showed significantly lower amounts of the dopamine and of the 5-hydroxytryptamine metabolites in CSF from the affected animals. Serotonin 179-198 colony stimulating factor 2 Canis lupus familiaris 214-217 9578395-0 1998 A role for serotonin in the circadian system revealed by the distribution of serotonin transporter and light-induced Fos immunoreactivity in the suprachiasmatic nucleus and intergeniculate leaflet. Serotonin 11-20 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 117-120 9578395-4 1998 Serotonin transporter, a plasma membrane protein located on serotonin neurons, regulates the amount of serotonin available for neurotransmission by re-accumulating released serotonin into presynaptic neurons; expression of Fos in the suprachiasmatic nucleus identifies light-activated cells involved in photic resetting of circadian clock phase. Serotonin 60-69 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 223-226 9578395-4 1998 Serotonin transporter, a plasma membrane protein located on serotonin neurons, regulates the amount of serotonin available for neurotransmission by re-accumulating released serotonin into presynaptic neurons; expression of Fos in the suprachiasmatic nucleus identifies light-activated cells involved in photic resetting of circadian clock phase. Serotonin 103-112 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 223-226 9630549-0 1998 Selective increases in serotonin 5-HT1B/1D and 5-HT2A/2C binding sites in adult rat basal ganglia following lesions of serotonergic neurons. Serotonin 23-32 5-hydroxytryptamine receptor 1B Rattus norvegicus 33-39 9630549-1 1998 Quantitative autoradiography was used to examine possible adaptive changes in serotonin 5-HT1B/1D and 5-HT2A/2C receptor binding sites in adult rat basal ganglia, after partial or severe lesions of serotonergic neurons produced by intraraphe injections of variable amounts of 5,7-dihydroxytryptamine. Serotonin 78-87 5-hydroxytryptamine receptor 1B Rattus norvegicus 88-94 9669494-1 1998 Pretreatment with the dopamine D2 receptor agonist quinpirole (0.025-2.5 mg/kg) produced a marked, dose-dependent, attenuation of the striatal Fos expression induced by the serotonin (5-Hydroxytryptamine, 5-HT) releasing agent fenfluramine (25 mg/kg). Serotonin 173-182 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 143-146 9669494-1 1998 Pretreatment with the dopamine D2 receptor agonist quinpirole (0.025-2.5 mg/kg) produced a marked, dose-dependent, attenuation of the striatal Fos expression induced by the serotonin (5-Hydroxytryptamine, 5-HT) releasing agent fenfluramine (25 mg/kg). Serotonin 184-203 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 143-146 29090817-4 1998 We confirmed this possibility by observing that both tryptophan hydroxylase (the synthesizing enzyme for serotonin) and the DA transporter, proteins particularly susceptible to oxidative modification, were rapidly (within 30 min), but reversibly (returned to control levels by 36 hr) inactivated by a single administration of METH. Serotonin 105-114 solute carrier family 6 member 3 Homo sapiens 124-138 6973044-4 1981 An intracerebral injection of L-5-hydroxytryptamine (5-HT) induced a similar backward walking which was potentiated by a MAOI. Serotonin 53-57 kinocilin Mus musculus 30-33 9695134-1 1998 Neonatal handling (during the first 3 weeks of age) has been reported by others to diminish the hypothalamo-pituitary-adrenal (HPA) responsivity to stress in adult Long Evans rats, an effect involving a serotonin (5-HT)2A receptor-mediated increase in glucocorticoid receptor (GR) gene expression in the frontal cortex and the hippocampus. Serotonin 203-212 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 252-275 9695134-1 1998 Neonatal handling (during the first 3 weeks of age) has been reported by others to diminish the hypothalamo-pituitary-adrenal (HPA) responsivity to stress in adult Long Evans rats, an effect involving a serotonin (5-HT)2A receptor-mediated increase in glucocorticoid receptor (GR) gene expression in the frontal cortex and the hippocampus. Serotonin 203-212 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 277-279 7218373-4 1981 This potentiating action of p-TA was related to the amount of the trace amine applied and was apparently specific for catecholamines, since depressant responses to 5-hydroxytryptamine and gamma-aminobutyric acid were unaffected. Serotonin 164-183 pre T-cell antigen receptor alpha Rattus norvegicus 28-32 9425141-3 1998 We find that loss-of-function eagle mutations produce an unusual differential phenotype with respect to the sister serotonin cells and that eagle is necessary for the maintenance of engrailed and zfh-2 expression in the serotonin neurons. Serotonin 115-124 engrailed Drosophila melanogaster 182-191 9425141-3 1998 We find that loss-of-function eagle mutations produce an unusual differential phenotype with respect to the sister serotonin cells and that eagle is necessary for the maintenance of engrailed and zfh-2 expression in the serotonin neurons. Serotonin 220-229 engrailed Drosophila melanogaster 182-191 7438716-5 1980 Motilin, whether detected by N-terminal or C-terminal specific antibodies showed similar density distributions with a modal density of 1.20, coinciding with the denser peak of serotonin. Serotonin 176-185 motilin Homo sapiens 0-7 9328047-0 1998 Cell body infusions of brain-derived neurotrophic factor increase forebrain dopamine release and serotonin metabolism determined with in vivo microdialysis. Serotonin 97-106 brain derived neurotrophic factor Homo sapiens 23-56 7438716-7 1980 These results lend support to the histochemical suggestions that motilin is located in a a serotonin-containing granule. Serotonin 91-100 motilin Homo sapiens 65-72 6968237-1 1980 The responsiveness of hippocampal CA3 pyramidal neurons to microiontophoretic applications of serotonin (5-HT), norepinephrine (NE), gamma-aminobutyric acid (GABA) and isoproterenol (ISO) was assessed in rats following 5,7-dihydroxy-tryptamine (5,7-DHT) and 6-hydroxydopamine (6-OHDA) pretreatments and bilateral locus coeruleus lesions. Serotonin 94-103 carbonic anhydrase 3 Rattus norvegicus 34-37 9414016-2 1998 [C-11]AMT is an analog of tryptophan, the precursor for serotonin synthesis, and is converted to alpha-[C-11]methyl-serotonin ([C-11]AM-5HT), which is trapped in serotonergic neurons because [C-11]AM-5HT is not degraded by monoamine oxidase. Serotonin 56-65 RNA polymerase III subunit K Homo sapiens 1-5 9414016-2 1998 [C-11]AMT is an analog of tryptophan, the precursor for serotonin synthesis, and is converted to alpha-[C-11]methyl-serotonin ([C-11]AM-5HT), which is trapped in serotonergic neurons because [C-11]AM-5HT is not degraded by monoamine oxidase. Serotonin 56-65 RNA polymerase III subunit K Homo sapiens 104-108 9414016-2 1998 [C-11]AMT is an analog of tryptophan, the precursor for serotonin synthesis, and is converted to alpha-[C-11]methyl-serotonin ([C-11]AM-5HT), which is trapped in serotonergic neurons because [C-11]AM-5HT is not degraded by monoamine oxidase. Serotonin 56-65 RNA polymerase III subunit K Homo sapiens 104-108 9414016-2 1998 [C-11]AMT is an analog of tryptophan, the precursor for serotonin synthesis, and is converted to alpha-[C-11]methyl-serotonin ([C-11]AM-5HT), which is trapped in serotonergic neurons because [C-11]AM-5HT is not degraded by monoamine oxidase. Serotonin 56-65 RNA polymerase III subunit K Homo sapiens 104-108 9414016-10 1998 This study demonstrates the suitability of [C-11]AMT as a tracer for PET scanning of serotonin synthesis capacity in human brain and provides normal adult values for future comparison with patient groups. Serotonin 85-94 RNA polymerase III subunit K Homo sapiens 44-48 6249462-0 1980 The action of 5-hydroxytryptamine on neuronal membranes and synaptic transmission in area CA1 of the hippocampus in vitro. Serotonin 14-33 carbonic anhydrase 1 Homo sapiens 90-93 9416904-4 1997 Two weeks after the operation, intracoronary serotonin repeatedly induced coronary hyperconstrictions at the IL-1beta-treated site both in vivo and in vitro, which were markedly inhibited by fasudil, an inhibitor of protein kinases, including protein kinase C and MLC kinase. Serotonin 45-54 myosin light chain 1 Sus scrofa 264-267 9416904-5 1997 Western blot analysis showed that during serotonin-induced contractions, MLC monophosphorylation was significantly increased and sustained in the spastic segment compared with the control segment, whereas MLC diphosphorylation was noted only in the spastic segment. Serotonin 41-50 myosin light chain 1 Sus scrofa 73-76 6249462-1 1980 Cell membrane properties and synaptic transmission were examined by intracellular recording from the CA1 region of hippocampal slices during application of 5-hydroxytryptamine (5-HT). Serotonin 156-175 carbonic anhydrase 1 Homo sapiens 101-104 9416904-5 1997 Western blot analysis showed that during serotonin-induced contractions, MLC monophosphorylation was significantly increased and sustained in the spastic segment compared with the control segment, whereas MLC diphosphorylation was noted only in the spastic segment. Serotonin 41-50 myosin light chain 1 Sus scrofa 205-208 6254118-0 1980 Possible mechanism of stimulation of gastrin secretion by exogenous serotonin in rats. Serotonin 68-77 gastrin Rattus norvegicus 37-44 9704050-5 1997 The present studies describe an additional biological activity of IL-1RA, inhibiting histamine and 5HT spontaneous release from RBLC cultures. Serotonin 99-102 interleukin 1 receptor antagonist Rattus norvegicus 66-72 9406963-1 1997 The purpose of the present study was to examine the role of 5-hydroxytryptamine (5-HT) neurons in mediating the effects of stress on proopiomelanocortin (POMC) gene expression in the anterior and intermediate lobes of the pituitary gland. Serotonin 60-79 proopiomelanocortin Rattus norvegicus 133-152 6254118-1 1980 The effect of 6-hydroxydopamine, propranolol, phentolamine, alpha-methyl-tyrosine and alpha-methyl-tyrosine plus propranolol on serotonin-stimulated gastrin secretion in rats has been examined. Serotonin 128-137 gastrin Rattus norvegicus 149-156 6254118-2 1980 Gastrin secretion in response to administration of serotonin alone (10 mg/kg i.p.) Serotonin 51-60 gastrin Rattus norvegicus 0-7 9325342-4 1997 Both [125I]AZIK and [125I]TBZ-AIPP photoaffinity labeling of purified rVMAT2 were protectable by 10 microM tetrabenazine (TBZ), 10 microM 7-aminoketanserin, and 1 mM concentrations of the transporter substrates dopamine, norepinephrine, and serotonin. Serotonin 241-250 solute carrier family 18 member A2 Rattus norvegicus 70-76 6254118-4 1980 These results suggest that the effect of exogenous serotonin on gastrin secretion can be described as sympathomimetic and indirect. Serotonin 51-60 gastrin Rattus norvegicus 64-71 6254118-5 1980 The serotonin-stimulated gastrin secretion was significantly enhanced by previous administration of phentolamine. Serotonin 4-13 gastrin Rattus norvegicus 25-32 9383015-9 1997 The present data suggest that serotonin, a preferential substrate for MAOA, can be oxidized by MAOB in MAOA-deficient Tg8 mice. Serotonin 30-39 monoamine oxidase B Rattus norvegicus 95-99 6254118-6 1980 Pretreatment with alpha-methyl-tyrosine also elevated serotonin-stimulated gastrin secretion, indicating that in the presence of diminished concentrations of the catecholamines, the influence of exogenous serotonin on secretion by G cells is increased. Serotonin 54-63 gastrin Rattus norvegicus 75-82 6254118-6 1980 Pretreatment with alpha-methyl-tyrosine also elevated serotonin-stimulated gastrin secretion, indicating that in the presence of diminished concentrations of the catecholamines, the influence of exogenous serotonin on secretion by G cells is increased. Serotonin 205-214 gastrin Rattus norvegicus 75-82 6254118-7 1980 This enhancement in the serum gastrin levels was also reduced to a significant extent by simultaneous administration of propranolol, which suggested the activation of G-cell beta-adrenergic receptors after serotonin administration. Serotonin 206-215 gastrin Rattus norvegicus 30-37 6985917-7 1980 At 0.25-0.5 U/ml of thrombin, phosphorylation preceded [3H]serotonin release with the time for half-maximal release being 26.0 +/- 1.3 s SE (n = 3) and the time for half-maximal phosphorylation being 12.3 +/- 1.3 s SE (n = 3) for P7P and 3.7 +/- 0.17 s SE (n = 3) for P9P. Serotonin 59-68 prothrombin Oryctolagus cuniculus 20-28 9406907-2 1997 Our results showed that the 5-hydroxytryptamine (5-HT) content in platelets was: (1) increased in the subgroup of anti-social alcoholics; (2) transiently and differently altered in alcoholics compared to opiate addicts; and (3) lowered in drinking alcoholics and normal in alcoholics who were drinking as well as smoking (that may occur via MAO-B inhibition by smoke). Serotonin 28-47 monoamine oxidase B Homo sapiens 341-346 9336334-1 1997 Administration of a single high dose of methamphetamine (METH) causes a rapid and reversible decrease in the activity of the tryptophan hydroxylase (TPH), the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine. Serotonin 200-219 tryptophan hydroxylase 1 Rattus norvegicus 125-147 6985917-8 1980 P9P phosphorylation was significantly inhibited (P less than 0.015) by removal by Ca2+ from the medium at a time point before any thrombin- or ionophore-induced serotonin release was detectable. Serotonin 161-170 prothrombin Oryctolagus cuniculus 130-138 9336334-1 1997 Administration of a single high dose of methamphetamine (METH) causes a rapid and reversible decrease in the activity of the tryptophan hydroxylase (TPH), the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine. Serotonin 200-219 tryptophan hydroxylase 1 Rattus norvegicus 149-152 6986577-1 1980 To determine if serotonin plays a role in the regulation of renin secretion, pentobarbital-anesthetized dogs were injected intravenously with drugs which modify serotonin metabolism. Serotonin 16-25 renin Canis lupus familiaris 60-65 314308-1 1979 The responses of isolated frog skin to 5-hydroxytryptamine (increased active sodium transport and decreased passive chloride permeability) are diminished by incubation with the enzymes neuraminidase and N-acetylneuraminic acid aldolase but only in the absence of Ca2+ and presence of EDTA. Serotonin 39-58 N-acetylneuraminate pyruvate lyase Homo sapiens 203-235 9437667-10 1997 These observations indicated that astrocytes are sensitive to the 5HT level, and in presence of low 5HT concentration in the intercellular space, astrocytes could react by synthesizing glial proteins like GFAP and S-100 protein. Serotonin 66-69 glial fibrillary acidic protein Rattus norvegicus 205-209 9437667-10 1997 These observations indicated that astrocytes are sensitive to the 5HT level, and in presence of low 5HT concentration in the intercellular space, astrocytes could react by synthesizing glial proteins like GFAP and S-100 protein. Serotonin 100-103 glial fibrillary acidic protein Rattus norvegicus 205-209 37558-1 1979 p,p"-DDT (600 mg/kg) produces myoclonic activity in mice which can be reduced by L-5-hydroxytryptophan (L-5HTP) (200 mg/kg), H75/12 (25 mg/kg), serotonin uptake blockers and two alpha-receptor blockers, phenoxybenzamine (5 mg/kg) and trazodone (5 mg/kg). Serotonin 144-153 histocompatibility 12 Mus musculus 125-131 9165122-11 1997 This report indicates for the first time that 5-HT2B receptors are actively mediating the action of serotonin on embryonic morphogenesis, probably by preventing the differentiation of cranial neural crest cells and myocardial precursor cells. Serotonin 100-109 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 46-52 361755-2 1978 In our studies serotonin was found to inhibit insulin responses to intravenous glucose. Serotonin 15-24 insulin Canis lupus familiaris 46-53 9088878-6 1997 In agreement with previous contraction studies, the generation of InsPs stimulated by 5-hydroxytryptamine was blocked by 10 nM ketanserin, a specific 5-HT2A receptor antagonist. Serotonin 86-105 5-hydroxytryptamine receptor 2A Ovis aries 150-156 9088878-8 1997 Our results suggest that through activation of 5-HT2A receptors, the generation of InsP3 plays a critical role in the contraction induced by 5-hydroxytryptamine in the ovine umbilical artery. Serotonin 141-160 5-hydroxytryptamine receptor 2A Ovis aries 47-53 9118699-0 1997 Serotonin-induced cortisol release in CPAP-treated obstructive sleep apnea patients. Serotonin 0-9 centromere protein J Homo sapiens 38-42 140743-1 1976 The effect of serotonin on glutamate decarboxylase and GABA-transaminase was studied, in vitro, in synaptosome homogenates from rat mesencephalon. Serotonin 14-23 glutamate-ammonia ligase Rattus norvegicus 27-50 140743-2 1976 Serotonin dissolved in the incubation medium inhibits glutamate decarboxylase activity and stimulates GABA-transaminase activity. Serotonin 0-9 glutamate-ammonia ligase Rattus norvegicus 54-77 9051332-1 1997 Long-acting somatostatin analogue (SMS 201-995) inhibits serotonin, bradykinin, prostaglandins, substance P, and vasoactive intestinal peptide, which may be involved in migraine. Serotonin 57-66 somatostatin Homo sapiens 12-24 1168649-5 1975 The primary reason for the reduced serotonin accumulation by the thrombin-treated platelets appears to be loss of amine storage granules or of the storage capacity within the granules. Serotonin 35-44 prothrombin Oryctolagus cuniculus 65-73 9241443-0 1997 Synergism of 5-HT 1B/D antagonists with paroxetine on serotonin efflux in rat ventral lateral geniculate nucleus slices. Serotonin 54-63 5-hydroxytryptamine receptor 1B Rattus norvegicus 13-20 793302-0 1975 The effect of serotonin (5-HT) on insulin secretion. Serotonin 14-23 insulin Canis lupus familiaris 34-41 9042572-0 1997 5-Hydroxytryptamine induces TIS8/egr-1 and c-fos expression in PC12 cells. Serotonin 0-19 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 43-48 9015328-2 1997 Serotonin and antidepressant drugs increase glucocorticoid receptor and mineralocorticoid receptor gene expression in hippocampal neurons over a few days. Serotonin 0-9 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 44-67 793302-1 1975 The present study was aimed at observing the effect on insulin secretion of serotonin (5-HT) administered intraportally to anesthetized adult dogs. Serotonin 76-85 insulin Canis lupus familiaris 55-62 9016944-1 1996 We previously reported a significant mitogenic effect of serotonin (5-hydroxytryptamine, 5-HT) on human small-cell lung carcinoma cells (SCLC, GLC-8), mediated by both 5-HT1D and 5-HT1A receptors. Serotonin 57-66 5-hydroxytryptamine receptor 1D Homo sapiens 168-174 793302-7 1975 In the in vitro studies, 5-HT at 100 mug/ml stimulated the output of insulin in the presence of a low concentration of glucose (0.6 mg/ml); when the islets were incubated with glucose at a higher concentration (3.0 mg/ml) there was a lower insulin release in the presence of serotonin (100 mug/ml) than that obtained with glucose alone at the same concentration (3.0 mug/ml). Serotonin 275-284 insulin Canis lupus familiaris 69-76 9016944-1 1996 We previously reported a significant mitogenic effect of serotonin (5-hydroxytryptamine, 5-HT) on human small-cell lung carcinoma cells (SCLC, GLC-8), mediated by both 5-HT1D and 5-HT1A receptors. Serotonin 68-87 5-hydroxytryptamine receptor 1D Homo sapiens 168-174 793302-8 1975 The results obtained suggest that serotonin stimulates insulin release under certain conditions in the intact dog and also in the isolated pancreatic islets of the mouse incubated in vitro. Serotonin 34-43 insulin Canis lupus familiaris 55-62 14282870-0 1964 [POSSIBILITIES OF INTERFERENCE OF KALLIKREIN ON THE PATHOGENIC MECHANISM OF EXPERIMENTAL PLACENTAL DETACHMENT DUE TO ADMINISTRATION OF 5-HYDROXYTRYPTAMINE (SEROTONIN)]. Serotonin 135-154 kallikrein related peptidase 4 Homo sapiens 34-44 8989773-6 1996 Furthermore, PF cells and PF cell lines are capable of expressing the fundamental properties of serotonergic neurons, including: (1) serotonin (5-HT) biosynthesis by tryptophan hydroxylase (TPH), (2) vesicular 5-HT storage and regulated release, (3) expression of a 5-HT autoreceptor, and (4) expression of the 5-HT transporter. Serotonin 133-142 tryptophan hydroxylase 1 Rattus norvegicus 166-188 14282870-0 1964 [POSSIBILITIES OF INTERFERENCE OF KALLIKREIN ON THE PATHOGENIC MECHANISM OF EXPERIMENTAL PLACENTAL DETACHMENT DUE TO ADMINISTRATION OF 5-HYDROXYTRYPTAMINE (SEROTONIN)]. Serotonin 156-165 kallikrein related peptidase 4 Homo sapiens 34-44 8923659-8 1996 The existence of 5-HT1B terminal heteroreceptors localised on primary visual afferents shows that serotonin might modulate the transmission of visual messages to the superior colliculus. Serotonin 98-107 5-hydroxytryptamine receptor 1B Rattus norvegicus 17-23 13729628-3 1961 The vasodepressor action of intravenously administered human salivary kallikrein in the anaesthetized dog was very markedly inhibited by the intravenous administration of doses of various analgesic-antipyretic drugs which only partially antagonized the responses to kallidin and bradykinin and which left the vasodepressor responses to histamine, acetylcholine and 5-hydroxytryptamine unaffected. Serotonin 365-384 kallikrein related peptidase 4 Homo sapiens 70-80 34000471-3 2021 Fluoxetine and 5-HT suppressed IL-17, IFN-gamma and GM-CSF production by stimulated SD4+ T-cells in both groups. Serotonin 15-19 interleukin 17A Homo sapiens 31-36 8898084-2 1996 In voltage-clamp experiments with rOCT1-expressing Xenopus oocytes, superfusion with dopamine, serotonin, noradrenaline, histamine and the permanent cation acetylcholine induced saturable inwardly directed currents with apparent Km values ranging from 20 to 100 microM. Serotonin 95-104 solute carrier family 22 member 1 Rattus norvegicus 34-39 8863849-1 1996 We previously reported that in Chinese hamster ovary (CHO) cells, 5-hydroxytryptamine (5-HT)1B-like (CHO/5-HT1B) receptor-mediated inhibition of forskolin-stimulated cAMP accumulation is inhibited by activation of transfected human 5-HT2C receptors but not 5-HT2A receptors. Serotonin 66-85 5-hydroxytryptamine receptor 2C Homo sapiens 232-238 34053940-5 2021 A docking simulation using a triple reuptake inhibitor 8k and a serotonin/norepinephrine reuptake inhibitor 7j showed that the regions spanning transmembrane domain (TM)1, TM3, and TM6 form the ligand binding pocket. Serotonin 64-73 tropomyosin 3 Homo sapiens 172-175 8841350-13 1996 In contrast, control vessels challenged with 2 to 8 mumol/L serotonin, which induced a magnitude of constriction similar to those of SAH and ET-1 (22%), completely relaxed in response to Ca(2+)-free solution and verapamil. Serotonin 60-69 endothelin-1 Oryctolagus cuniculus 141-145 33785354-1 2021 The early characterization of ligands at the dopamine and serotonin transporters, DAT and SERT, respectively, is important for drug discovery, forensic sciences, and drug abuse research. Serotonin 58-67 solute carrier family 6 member 3 Homo sapiens 82-85 33984269-3 2021 Here, we show that in C. elegans, loss of neuronal fzo-1/mitofusin induces nonautonomous UPRmt through multiple neurotransmitters and neurohormones, including acetylcholine, serotonin, glutamate, tyramine, and insulin-like peptides. Serotonin 174-183 Transmembrane GTPase fzo-1 Caenorhabditis elegans 51-56 8756010-4 1996 The post-embedding immunocytochemistry, which can detect levels of label in individual cells, showed that there was a significant decrease in endothelial NO synthase (NOS3)-labeled, serotonin (5-HT)-labeled, and substance P (SP)-labeled, but a significant increase in endothelin-1 (ET-1)-labeled, gold particles in ECs after long-term, but not after short-term (3-day), sympathectomy. Serotonin 182-191 nitric oxide synthase 3 Rattus norvegicus 167-171 8756010-4 1996 The post-embedding immunocytochemistry, which can detect levels of label in individual cells, showed that there was a significant decrease in endothelial NO synthase (NOS3)-labeled, serotonin (5-HT)-labeled, and substance P (SP)-labeled, but a significant increase in endothelin-1 (ET-1)-labeled, gold particles in ECs after long-term, but not after short-term (3-day), sympathectomy. Serotonin 193-197 nitric oxide synthase 3 Rattus norvegicus 167-171 33949019-0 2021 Serotonin 5-HT7 receptors require Cyclin-Dependent Kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome. Serotonin 0-9 cyclin-dependent kinase 5 Mus musculus 34-59 8877164-6 1996 Serotonin release was measured after challenge of sensitized cells with trinitrophenylated human serum albumin (TNP-HSA). Serotonin 0-9 albumin Rattus norvegicus 97-110 8690054-3 1996 Brain-derived neurotrophic factor (BDNF) regulates the in vitro survival and serotonergic phenotype of RN46A cells, and we hypothesized that expression of BDNF in RN46A cells would potentiate their survival and serotonin (5HT) expression in vivo. Serotonin 211-220 brain-derived neurotrophic factor Rattus norvegicus 0-33 33949019-3 2021 We have previously demonstrated that activation of serotonin 5-HT7 receptors reverses mGluR-LTD in the hippocampus of wild-type and Fmr1 KO mice, thus correcting a synaptic dysfunction typically observed in this disease model. Serotonin 51-60 fragile X messenger ribonucleoprotein 1 Mus musculus 132-136 8690054-3 1996 Brain-derived neurotrophic factor (BDNF) regulates the in vitro survival and serotonergic phenotype of RN46A cells, and we hypothesized that expression of BDNF in RN46A cells would potentiate their survival and serotonin (5HT) expression in vivo. Serotonin 211-220 brain-derived neurotrophic factor Rattus norvegicus 35-39 8690054-3 1996 Brain-derived neurotrophic factor (BDNF) regulates the in vitro survival and serotonergic phenotype of RN46A cells, and we hypothesized that expression of BDNF in RN46A cells would potentiate their survival and serotonin (5HT) expression in vivo. Serotonin 211-220 brain-derived neurotrophic factor Rattus norvegicus 155-159 8690054-3 1996 Brain-derived neurotrophic factor (BDNF) regulates the in vitro survival and serotonergic phenotype of RN46A cells, and we hypothesized that expression of BDNF in RN46A cells would potentiate their survival and serotonin (5HT) expression in vivo. Serotonin 222-225 brain-derived neurotrophic factor Rattus norvegicus 0-33 8690054-3 1996 Brain-derived neurotrophic factor (BDNF) regulates the in vitro survival and serotonergic phenotype of RN46A cells, and we hypothesized that expression of BDNF in RN46A cells would potentiate their survival and serotonin (5HT) expression in vivo. Serotonin 222-225 brain-derived neurotrophic factor Rattus norvegicus 35-39 8690054-3 1996 Brain-derived neurotrophic factor (BDNF) regulates the in vitro survival and serotonergic phenotype of RN46A cells, and we hypothesized that expression of BDNF in RN46A cells would potentiate their survival and serotonin (5HT) expression in vivo. Serotonin 222-225 brain-derived neurotrophic factor Rattus norvegicus 155-159 8690054-4 1996 The gene encoding rat BDNF was transfected into RN46A cells and the clonal 46A-B14 cell line isolated, 46A-B14 cells synthesize and secrete biologically active BDNF in vitro and synthesize 5HT following partial membrane depolarization. Serotonin 189-192 brain-derived neurotrophic factor Rattus norvegicus 22-26 8690054-8 1996 Autocrine secretion of BDNF by RN46A cells thus potentiates survival and can be used to deliver both BDNF and 5HT in vivo. Serotonin 110-113 brain-derived neurotrophic factor Rattus norvegicus 23-27 33571572-3 2021 However, it is still unknown whether this mechanism accounts for the antipanic effect of other classes of antidepressants drugs (ADs) and whether the 5-HT interaction with 5-HT2C receptors in this midbrain area (which increases anxiety) is implicated in the anxiogenic effect caused by short-term treatment with ADs. Serotonin 150-154 5-hydroxytryptamine receptor 2C Rattus norvegicus 172-178 8921260-7 1996 In addition, BDNF increased backwards walking, a behaviour that requires the activation of both dopamine and serotonin systems. Serotonin 109-118 brain-derived neurotrophic factor Rattus norvegicus 13-17 8755606-3 1996 cis-9,10-Octadecenamide (ODA) markedly potentiated the action of 5-hydroxytryptamine (5-HT) on 5-HT2A and 5-HT2C receptors, but this action was not shared by related compounds such as oleic acid and trans-9,10-octacenamide. Serotonin 65-84 5-hydroxytryptamine receptor 2C Rattus norvegicus 106-112 33895323-6 2021 Importantly, Gsx1 reduces reactive astrogliosis and glial scar formation, promotes 5-HT neuronal activity, and improves the locomotor function of the injured mice. Serotonin 83-87 GS homeobox 1 Mus musculus 13-17 8807295-4 1996 Here we report that mutants defective in the unc-36 gene, which encodes a homologue of a calcium channel auxiliary subunit, are also serotonin-hypersensitive. Serotonin 133-142 VWFA domain-containing protein;Voltage-dependent calcium channel unc-36 Caenorhabditis elegans 45-51 8792040-1 1996 The oral absorption of a 10-mg oral dose of the novel 5-hydroxytryptamine (5HT1D) agonist, 311C90, was compared during a moderate or severe migraine headache and in a migraine-free period in an open, two-period study. Serotonin 54-73 5-hydroxytryptamine receptor 1D Homo sapiens 75-80 33930757-2 2021 Keeping in mind the favorable effects of oxytocin on animal models of anxiety and depression, we postulated that synergy between prescribed first choice drugs, selective serotonin reuptake inhibitors (SSRIs) and oxytocin could improve the treatment outcome compared with SSRI monotherapy. Serotonin 170-179 oxytocin/neurophysin I prepropeptide Homo sapiens 41-49 8738141-0 1996 Fenfluramine-induced activation of the immediate-early gene c-fos in the striatum: possible interaction between serotonin and dopamine. Serotonin 112-121 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 60-65 33930757-2 2021 Keeping in mind the favorable effects of oxytocin on animal models of anxiety and depression, we postulated that synergy between prescribed first choice drugs, selective serotonin reuptake inhibitors (SSRIs) and oxytocin could improve the treatment outcome compared with SSRI monotherapy. Serotonin 170-179 oxytocin/neurophysin I prepropeptide Homo sapiens 212-220 8743190-9 1996 Immunoelectron microscopy indicated the presence of LAMP-2 in the membranes of serotonin-containing granules as identified by an anti-serotonin polyclonal antibody. Serotonin 79-88 lysosomal associated membrane protein 2 Homo sapiens 52-58 33837045-10 2021 Significance Statement 5-hydroxytryptamine (serotonin) type 2C (5-HT2C) receptor stimulation by TAK-233 enhanced urethral resistance in rats during an evoked momentary event in which the bladder afferent-independent or -dependent reflex functions via striated muscle-mediated mechanisms. Serotonin 23-42 5-hydroxytryptamine receptor 2C Rattus norvegicus 64-70 8814905-4 1996 These results suggest that the ability of similar infusions of BDNF to produce behavioral effects (i.e. analgesia and an antidepressant-like effect) associated with elevated serotonin turnover may be in part the result of more irregular firing patterns of dorsal raphe neurons. Serotonin 174-183 brain-derived neurotrophic factor Rattus norvegicus 63-67 8626761-0 1996 Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 10-16 33837045-10 2021 Significance Statement 5-hydroxytryptamine (serotonin) type 2C (5-HT2C) receptor stimulation by TAK-233 enhanced urethral resistance in rats during an evoked momentary event in which the bladder afferent-independent or -dependent reflex functions via striated muscle-mediated mechanisms. Serotonin 44-53 5-hydroxytryptamine receptor 2C Rattus norvegicus 64-70 8626761-11 1996 Serotonin also stimulated the release of the APLP2 ectodomain, suggesting that additional members of the APP multigene family are processed via similar regulated pathways. Serotonin 0-9 amyloid beta (A4) precursor-like protein 2 Mus musculus 45-50 33909316-4 2021 The serotonin 2C receptor (5-HT2C R) is the primary receptor through which 5-HT impacts feeding and body weight and 5-HT2C R agonist lorcaserin was released for obesity treatment in 2012. Serotonin 4-13 5-hydroxytryptamine receptor 2C Homo sapiens 27-33 8621713-2 1996 Here, we show that agonist stimulation of the 5-HT2B receptor subtype stably expressed in the mouse fibroblast LMTK- cell line causes a rapid and transient activation of the proto-oncogene product p21ras as measured by an increase in GTP-bound Ras in response to serotonin. Serotonin 263-272 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 197-200 8869564-7 1996 There was a significant and positive correlation (r = +0.86) between plasma levels of BDNF and serotonin, an indoleamine that is specifically released from activated platelets. Serotonin 95-104 brain derived neurotrophic factor Homo sapiens 86-90 33581143-1 2021 Within the hindbrain, serotonin (5-HT) functions as a modulator of the central glucagon-like peptide-1 (GLP-1) system. Serotonin 22-31 glucagon Rattus norvegicus 79-102 8772497-0 1996 Role of endogenous 5-hydroxytryptamine in the regulation of gastric contractions by motilin in dogs. Serotonin 19-38 motilin Canis lupus familiaris 84-91 8788473-9 1996 The activating effects of indirect agonists such as 3,4-methylenedioxy-methamphetamine (MDMA), para-chloroamphetamine (PCA), or alpha-ethyltryptamine are dependent upon the release of serotonin from presynaptic terminals and are mimicked by direct agonists at 5-HT1B receptors. Serotonin 184-193 5-hydroxytryptamine receptor 1B Rattus norvegicus 260-266 33581143-1 2021 Within the hindbrain, serotonin (5-HT) functions as a modulator of the central glucagon-like peptide-1 (GLP-1) system. Serotonin 22-31 glucagon Rattus norvegicus 104-109 8880055-1 1996 OBJECTIVE: The purpose of this pharmacokinetic study was to investigate the dose-dependent inhibition of model substrates for CYP2D6, CYP2C19 and CYP1A2 by four marketed selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine and paroxetine. Serotonin 180-189 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 134-141 33581143-1 2021 Within the hindbrain, serotonin (5-HT) functions as a modulator of the central glucagon-like peptide-1 (GLP-1) system. Serotonin 33-37 glucagon Rattus norvegicus 79-102 33581143-1 2021 Within the hindbrain, serotonin (5-HT) functions as a modulator of the central glucagon-like peptide-1 (GLP-1) system. Serotonin 33-37 glucagon Rattus norvegicus 104-109 8881571-6 1996 CONCLUSION: These results suggest that the CCK control in triggering transient lower esophageal sphincter relaxations is modulated by serotonin via 5-HT3 receptors subtypes. Serotonin 134-143 cholecystokinin Canis lupus familiaris 43-46 33581143-2 2021 This interaction between 5-HT and GLP-1 is achieved via 5-HT2C and 5-HT3 receptors and is relevant for GLP-1-mediated feeding behavior. Serotonin 25-29 glucagon Rattus norvegicus 34-39 8698676-1 1996 The article focuses on the effects of the serotonin selective reuptake inhibitors (SSRIs) on specific drug metabolizing isoenzymes: CYP2D6, CYP3A3/4, CYP1A2, CYP2C9, and CYP2C19. Serotonin 42-51 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 170-177 33581143-2 2021 This interaction between 5-HT and GLP-1 is achieved via 5-HT2C and 5-HT3 receptors and is relevant for GLP-1-mediated feeding behavior. Serotonin 25-29 5-hydroxytryptamine receptor 2C Rattus norvegicus 56-62 8812058-3 1996 Here we show that the normal differentiation of the serotonin neurons of the Drosophila nerve cord is dependent on the expression of two pattern formation genes, huckebein (hkb) and engrailed (en). Serotonin 52-61 engrailed Drosophila melanogaster 182-191 33581143-2 2021 This interaction between 5-HT and GLP-1 is achieved via 5-HT2C and 5-HT3 receptors and is relevant for GLP-1-mediated feeding behavior. Serotonin 25-29 glucagon Rattus norvegicus 103-108 8812058-3 1996 Here we show that the normal differentiation of the serotonin neurons of the Drosophila nerve cord is dependent on the expression of two pattern formation genes, huckebein (hkb) and engrailed (en). Serotonin 52-61 engrailed Drosophila melanogaster 35-37 33581143-4 2021 Whether 5-HT modulates GLP-1"s role in the stress response in unknown. Serotonin 8-12 glucagon Rattus norvegicus 23-28 33581143-8 2021 Additionally, stressors that depend on 5-HT signaling to activate PPG neurons (i.e., LiCl and RES) increased c-Fos expression in 5-HT-expressing neurons within the caudal raphe (CR), specifically in the raphe magnus (RMg). Serotonin 39-43 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 109-114 9025099-5 1996 It is concluded that: (1) serotonin interacts with the mesolimbic dopaminergic system through 5-HT1B, but not 5-HT1A, receptors: and (2) serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5-HT1B heteroreceptors located in the ventral subicular area, which modulate the activity of glutamatergic hippocampo-accumbens pathways and only secondarily alter DA levels in the n. acc. Serotonin 26-35 5-hydroxytryptamine receptor 1B Rattus norvegicus 94-100 9025099-5 1996 It is concluded that: (1) serotonin interacts with the mesolimbic dopaminergic system through 5-HT1B, but not 5-HT1A, receptors: and (2) serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5-HT1B heteroreceptors located in the ventral subicular area, which modulate the activity of glutamatergic hippocampo-accumbens pathways and only secondarily alter DA levels in the n. acc. Serotonin 26-35 5-hydroxytryptamine receptor 1B Rattus norvegicus 223-229 33581143-8 2021 Additionally, stressors that depend on 5-HT signaling to activate PPG neurons (i.e., LiCl and RES) increased c-Fos expression in 5-HT-expressing neurons within the caudal raphe (CR), specifically in the raphe magnus (RMg). Serotonin 129-133 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 109-114 9025099-5 1996 It is concluded that: (1) serotonin interacts with the mesolimbic dopaminergic system through 5-HT1B, but not 5-HT1A, receptors: and (2) serotonin interaction with the mesolimbic dopaminergic system involves postjunctional 5-HT1B heteroreceptors located in the ventral subicular area, which modulate the activity of glutamatergic hippocampo-accumbens pathways and only secondarily alter DA levels in the n. acc. Serotonin 137-146 5-hydroxytryptamine receptor 1B Rattus norvegicus 223-229 33581143-10 2021 Together, these findings identify a direct RMg to NTS pathway responsible for the modulatory effect of 5-HT on the central GLP-1 system-specifically via activation of 5-HT2C and 5-HT3 receptors-in the facilitation of acute stress responses. Serotonin 103-107 glucagon Rattus norvegicus 123-128 8871296-0 1995 [The involvement of protein kinase C isozymes in activation of phospholipase D and secretion of serotonin in rat basophilic leukemia cells]. Serotonin 96-105 protein kinase C, gamma Rattus norvegicus 20-36 33581143-10 2021 Together, these findings identify a direct RMg to NTS pathway responsible for the modulatory effect of 5-HT on the central GLP-1 system-specifically via activation of 5-HT2C and 5-HT3 receptors-in the facilitation of acute stress responses. Serotonin 103-107 5-hydroxytryptamine receptor 2C Rattus norvegicus 167-173 8871296-11 1995 These results indicate that translocation of PKC alpha and beta may be associated with PLD activation and also that both translocation of PKCalpha and epsilon and intracellular calcium increase are required for serotonin secretion in RBL cells. Serotonin 211-220 protein kinase C, alpha Rattus norvegicus 45-54 33611213-9 2021 Furthermore, the binding affinities and pKi values of WA, fluoxetine and serotonin as natural ligand to Ser-1, Ser-4, Ser-7, Mod-5 and their human orthologues proteins were calculated by molecular docking. Serotonin 73-82 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 118-123 8871296-11 1995 These results indicate that translocation of PKC alpha and beta may be associated with PLD activation and also that both translocation of PKCalpha and epsilon and intracellular calcium increase are required for serotonin secretion in RBL cells. Serotonin 211-220 protein kinase C, alpha Rattus norvegicus 138-146 33833791-2 2021 To characterize gene regulation mediated by small noncoding RNAs associated with long-term memory in Aplysia, we consider two noncoding RNAs stimulated by 5-HT into a gene regulatory network motif model, including miR-124 that binds to and inhibits the mRNA of CREB1 and piR-F that facilitates serotonin-dependent DNA methylation to lead to repression of CREB2. Serotonin 155-159 cAMP responsive element binding protein 1 Homo sapiens 261-266 7585805-2 1995 We aimed to determine if ET-1 is involved in serotonin-induced coronary spasm in the swine model. Serotonin 45-54 endothelin-1 Sus scrofa 25-29 33833791-2 2021 To characterize gene regulation mediated by small noncoding RNAs associated with long-term memory in Aplysia, we consider two noncoding RNAs stimulated by 5-HT into a gene regulatory network motif model, including miR-124 that binds to and inhibits the mRNA of CREB1 and piR-F that facilitates serotonin-dependent DNA methylation to lead to repression of CREB2. Serotonin 155-159 activating transcription factor 2 Homo sapiens 355-360 7790867-4 1995 The greatest increase (given as a percentage of rates in control animals) in the rate of serotonin synthesis was observed in the substantia nigra compacta (344%), hippocampus-CA3 (337%), dorsal hippocampus (283%), and caudate-putamen (232%). Serotonin 89-98 carbonic anhydrase 3 Rattus norvegicus 175-178 33833791-4 2021 More importantly, we verify three stimulus protocols of 5-HT in experiments by our model and find that application of five pulses of 5-HT leads to a transient decrease of miR-124 but increase of piR-F concentrations, which matters sustained high level of CREB1 concentration associated with long-term memory. Serotonin 56-60 cAMP responsive element binding protein 1 Homo sapiens 255-260 33833791-4 2021 More importantly, we verify three stimulus protocols of 5-HT in experiments by our model and find that application of five pulses of 5-HT leads to a transient decrease of miR-124 but increase of piR-F concentrations, which matters sustained high level of CREB1 concentration associated with long-term memory. Serotonin 133-137 cAMP responsive element binding protein 1 Homo sapiens 255-260 7539147-7 1995 The enhanced vasoconstriction to angiotensin II, serotonin, KCl, and phenylephrine could be mimicked in normal vessels by addition of subthreshold concentrations of endothelin 1, and this effect was prevented by calphostin C. Serotonin 49-58 endothelin-1 Oryctolagus cuniculus 165-177 33677046-1 2021 BACKGROUND: Tryptophan hydroxylase 2 (TPH2) is a key enzyme in the biosynthesis of serotonin in the brain. Serotonin 83-92 tryptophan hydroxylase 2 Homo sapiens 12-36 7612155-4 1995 In addition, c-fos induction in response to acute restraint stress was down-regulated by chronic, but not acute, administration of tranylcypromine or imipramine, two drugs that nonselectively increase synaptic levels of norepinephrine and serotonin by inhibition of monoamine oxidase or neurotransmitter reuptake, respectively. Serotonin 239-248 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 7612155-5 1995 Moreover, chronic administration of desipramine or sertraline, selective re-uptake inhibitors of norepinephrine, or serotonin, respectively, also significantly down-regulated the induction of c-fos mRNA in response to restraint stress. Serotonin 116-125 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 192-197 7485253-0 1995 Mapping of the serotonin 5-HT1D alpha autoreceptor gene (HTR1D) on chromosome 1 using a silent polymorphism in the coding region. Serotonin 15-24 5-hydroxytryptamine receptor 1D Homo sapiens 25-37 7485253-0 1995 Mapping of the serotonin 5-HT1D alpha autoreceptor gene (HTR1D) on chromosome 1 using a silent polymorphism in the coding region. Serotonin 15-24 5-hydroxytryptamine receptor 1D Homo sapiens 57-62 33677046-1 2021 BACKGROUND: Tryptophan hydroxylase 2 (TPH2) is a key enzyme in the biosynthesis of serotonin in the brain. Serotonin 83-92 tryptophan hydroxylase 2 Homo sapiens 38-42 33679889-5 2021 The analysis of whole exome sequencing (WES) data with bioinformatic tools for oligogenic diseases helped us to identify two major previously unreported pathogenetic variants: a maternally inherited missense variant (p.R4122H) in HUWE1, an ubiquitin protein ligase associated to X-linked intellectual disability and ASD; and a de novo stop variant (p.Q259X) in TPH2, encoding the tryptophan hydroxylase 2 enzyme involved in serotonin synthesis and associated with susceptibility to attention deficit-hyperactivity disorder (ADHD). Serotonin 424-433 tryptophan hydroxylase 2 Homo sapiens 361-365 33679889-5 2021 The analysis of whole exome sequencing (WES) data with bioinformatic tools for oligogenic diseases helped us to identify two major previously unreported pathogenetic variants: a maternally inherited missense variant (p.R4122H) in HUWE1, an ubiquitin protein ligase associated to X-linked intellectual disability and ASD; and a de novo stop variant (p.Q259X) in TPH2, encoding the tryptophan hydroxylase 2 enzyme involved in serotonin synthesis and associated with susceptibility to attention deficit-hyperactivity disorder (ADHD). Serotonin 424-433 tryptophan hydroxylase 2 Homo sapiens 380-404 32991927-0 2021 The effect of 5-HT4 serotonin receptors in the CA3 hippocampal region on D-AP5-induced anxiolytic-like effects: isobolographic analyses. Serotonin 20-29 carbonic anhydrase 3 Rattus norvegicus 47-50 33451281-3 2021 Acute treadmill running at low speed, regardless of exercise duration, significantly increased c-Fos expression in 5-HT neurons in the DRN compared with controls, whereas high-speed running significantly activated 5-HT neurons only at 60-min duration. Serotonin 115-119 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 95-100 33451281-5 2021 c-Fos expression in 5-HT neurons in the DRN induced by the acute treadmill running for 30 or 60 min, but not 15 min, was positively correlated with the time spent on the open arms in the EPM and was negatively correlated with the immobility time in the FST. Serotonin 20-24 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 0-5 33598202-0 2021 Involvement of 5-HT-BDNF signaling axis in mediating synergistic antidepressant-like effects after combined administration of two oligosaccharide esters. Serotonin 15-19 brain derived neurotrophic factor Homo sapiens 20-24 33598202-2 2021 To identify potentially new combined therapeutic strategies, 3,6"-disinapoylsucrose (DISS) and tenuifoliside A (TFSA) have been observed to show antidepressant-like effects and its related 5-HT-BDNF pathway. Serotonin 189-193 brain derived neurotrophic factor Homo sapiens 194-198 33231727-3 2021 The inhibitory effects of CRF on 5-HT DRN neurons are indirect, mediated by CRF-R1 receptors located on GABAergic afferents. Serotonin 33-37 corticotropin releasing hormone receptor 1 Rattus norvegicus 76-82 33364514-0 2020 Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice. Serotonin 28-37 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 38-43 33364514-0 2020 Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice. Serotonin 28-37 stromal cell-derived factor 2-like 1 Mus musculus 115-121 33364514-0 2020 Pharmacologic inhibition of serotonin htr2b ameliorates hyperglycemia and the altered expression of hepatic FGF21, Sdf2l1, and htr2a in db/db mice and KKAy mice. Serotonin 28-37 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 127-132 33161374-5 2020 In the present study, the expression of HAP1 in pyloric stomach in adult male rats and its relationships with different chemical markers for EEC [gastrin, marker of gastrin (G) cells; somatostatin, marker of delta (D) cells; 5-HT, marker of enterochromaffin (EC) cells; histamine, marker of enterochromaffin-like (ECL) cells] were examined employing single- or double-labelled immunohistochemistry and with light-, fluorescence- or electron-microscopy. Serotonin 225-229 huntingtin-associated protein 1 Rattus norvegicus 40-44 32710540-2 2020 Serotonin 5-HT2C receptor (HTR2C) plays a critical role in hyperphagia and weight gain induced by AAPs, and expression of phosphatase tensin homolog (PTEN) in the hypothalamus also affects feeding behavior and weight change. Serotonin 0-9 5-hydroxytryptamine receptor 2C Rattus norvegicus 27-32 32738671-1 2020 INTRODUCTION: The gene tryptophan hydroxylase 2 (TPH2) encodes the associated rate-limiting enzyme in the biosynthesis 5-HT (serotonin). Serotonin 119-123 tryptophan hydroxylase 2 Homo sapiens 23-47 32738671-1 2020 INTRODUCTION: The gene tryptophan hydroxylase 2 (TPH2) encodes the associated rate-limiting enzyme in the biosynthesis 5-HT (serotonin). Serotonin 119-123 tryptophan hydroxylase 2 Homo sapiens 49-53 32738671-1 2020 INTRODUCTION: The gene tryptophan hydroxylase 2 (TPH2) encodes the associated rate-limiting enzyme in the biosynthesis 5-HT (serotonin). Serotonin 125-134 tryptophan hydroxylase 2 Homo sapiens 23-47 32738671-1 2020 INTRODUCTION: The gene tryptophan hydroxylase 2 (TPH2) encodes the associated rate-limiting enzyme in the biosynthesis 5-HT (serotonin). Serotonin 125-134 tryptophan hydroxylase 2 Homo sapiens 49-53 32828972-2 2020 We have previously shown elevated serotonin (5-HT) turnover rate in Lsamp-deficient mice. Serotonin 34-43 limbic system-associated membrane protein Mus musculus 68-73 32828972-2 2020 We have previously shown elevated serotonin (5-HT) turnover rate in Lsamp-deficient mice. Serotonin 45-49 limbic system-associated membrane protein Mus musculus 68-73 32828972-4 2020 Chronic (18 days) administration of serotonin reuptake inhibitor (SSRI) escitalopram (10 mg/kg) significantly increased general activity in wild-type mice in the open field and protected exploration in Lsamp-/- mice in the elevated-plus maze. Serotonin 36-45 limbic system-associated membrane protein Mus musculus 202-207 32828972-5 2020 An important psychopathology-related endophenotype, elevated 5-HT turnover in the brain of Lsamp-deficient mice, was reproduced in the saline group. Serotonin 61-65 limbic system-associated membrane protein Mus musculus 91-96 32828972-6 2020 Escitalopram restored the elevated 5-HT turnover of Lsamp-deficient mice to a level comparable with their wild-type littermates, suggesting that high 5-HT turnover in mutants is mediated by the increased activity of serotonin transporter (SERT protein encoded by Slc6a4 gene). Serotonin 35-39 limbic system-associated membrane protein Mus musculus 52-57 32828972-6 2020 Escitalopram restored the elevated 5-HT turnover of Lsamp-deficient mice to a level comparable with their wild-type littermates, suggesting that high 5-HT turnover in mutants is mediated by the increased activity of serotonin transporter (SERT protein encoded by Slc6a4 gene). Serotonin 150-154 limbic system-associated membrane protein Mus musculus 52-57 32828972-6 2020 Escitalopram restored the elevated 5-HT turnover of Lsamp-deficient mice to a level comparable with their wild-type littermates, suggesting that high 5-HT turnover in mutants is mediated by the increased activity of serotonin transporter (SERT protein encoded by Slc6a4 gene). Serotonin 216-225 limbic system-associated membrane protein Mus musculus 52-57 32828972-10 2020 The activity of Lsamp gene promoters varied in 5-HT producing nuclei: both Lsamp 1a and 1b promoters were active in the dorsal raphe; most of the expression in the median raphe was from 1b promoter, whereas Lsamp 1a promoter was almost exclusively active in the caudal subgroup of raphe nuclei. Serotonin 47-51 limbic system-associated membrane protein Mus musculus 16-21 33088927-4 2020 Relevant to potential behavioral effects of vitamin D, urolithin A elicits enhancement of 1,25D-dependent mRNA encoding tryptophan hydroxylase-2 (TPH2), the serotonergic neuron-expressed initial enzyme in tryptophan metabolism to serotonin. Serotonin 230-239 tryptophan hydroxylase 2 Rattus norvegicus 146-150 32666125-9 2020 CONCLUSIONS: These results are the first strong evidence supporting the hypothesis that dehydroleucodine and xanthatin inhibit substance P- and neurotensin-induced serotonin release from rat peritoneal mast cells. Serotonin 164-173 neurotensin Rattus norvegicus 144-155 32827262-0 2020 Serotonin receptor HTR4 as a counter actor of lipid-induced increases of serum glucagon-like peptide-1 levels. Serotonin 0-9 5-hydroxytryptamine receptor 4 Homo sapiens 19-23 32590336-7 2020 IDO and TDO are especially of interest in NETs since some tumours produce serotonin but the majority do not, which potentially deplete the precursor tryptophan. Serotonin 74-83 tryptophan 2,3-dioxygenase Homo sapiens 8-11 32868775-0 2020 CXCR4hi effector neutrophils in sickle cell anemia: potential role for elevated circulating serotonin (5-HT) in CXCR4hi neutrophil polarization. Serotonin 92-101 C-X-C motif chemokine receptor 4 Homo sapiens 112-117 32868775-0 2020 CXCR4hi effector neutrophils in sickle cell anemia: potential role for elevated circulating serotonin (5-HT) in CXCR4hi neutrophil polarization. Serotonin 103-107 C-X-C motif chemokine receptor 4 Homo sapiens 112-117 32868775-6 2020 SCA individuals had significantly increased plasma levels of serotonin (5-HT), and serotonin molecule and SCA plasma induced neutrophil CXCR4 expression in a serotonin-receptor-dependent manner. Serotonin 83-92 C-X-C motif chemokine receptor 4 Homo sapiens 136-141 32868775-6 2020 SCA individuals had significantly increased plasma levels of serotonin (5-HT), and serotonin molecule and SCA plasma induced neutrophil CXCR4 expression in a serotonin-receptor-dependent manner. Serotonin 83-92 C-X-C motif chemokine receptor 4 Homo sapiens 136-141 32868775-7 2020 Thus, the augmented CXCR4hi neutrophil population may contribute to mechanisms that promote vaso-occlusion in SCA; furthermore, circulating serotonin, derived from platelet activation, may play a role in the polarization of neutrophils, suggesting that serotonin-receptor antagonists or serotonin reuptake inhibitors could represent therapeutic approaches to reduce neutrophil activation in SCA. Serotonin 140-149 C-X-C motif chemokine receptor 4 Homo sapiens 20-25 32868775-7 2020 Thus, the augmented CXCR4hi neutrophil population may contribute to mechanisms that promote vaso-occlusion in SCA; furthermore, circulating serotonin, derived from platelet activation, may play a role in the polarization of neutrophils, suggesting that serotonin-receptor antagonists or serotonin reuptake inhibitors could represent therapeutic approaches to reduce neutrophil activation in SCA. Serotonin 253-262 C-X-C motif chemokine receptor 4 Homo sapiens 20-25 32868775-7 2020 Thus, the augmented CXCR4hi neutrophil population may contribute to mechanisms that promote vaso-occlusion in SCA; furthermore, circulating serotonin, derived from platelet activation, may play a role in the polarization of neutrophils, suggesting that serotonin-receptor antagonists or serotonin reuptake inhibitors could represent therapeutic approaches to reduce neutrophil activation in SCA. Serotonin 253-262 C-X-C motif chemokine receptor 4 Homo sapiens 20-25 32640190-6 2020 Notably, fecal ssRNA was identified as a natural Piezo1 ligand, and ssRNA-stimulated 5-HT synthesis from the gut was evoked in a MyD88/TRIF-independent manner. Serotonin 85-89 myeloid differentiation primary response gene 88 Mus musculus 129-134 32640190-6 2020 Notably, fecal ssRNA was identified as a natural Piezo1 ligand, and ssRNA-stimulated 5-HT synthesis from the gut was evoked in a MyD88/TRIF-independent manner. Serotonin 85-89 toll-like receptor adaptor molecule 2 Mus musculus 135-139 32311818-6 2020 RESULTS: We obtained the first evidence that serotonin is massively taken up from the fetal circulation by OCT3. Serotonin 45-54 solute carrier family 22 member 3 Homo sapiens 107-111 31785784-0 2020 Corrigendum to "Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c" [J. Psychiatr Res. Serotonin 72-81 integrin subunit alpha M Homo sapiens 116-121 32547368-3 2020 In this context, we investigated if the glucocorticoid receptor (GR) genomic pathway activation was altered by the lack of serotonin in the central nervous system. Serotonin 123-132 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 40-63 32547368-3 2020 In this context, we investigated if the glucocorticoid receptor (GR) genomic pathway activation was altered by the lack of serotonin in the central nervous system. Serotonin 123-132 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 65-67 32547368-11 2020 Overall our findings suggest that the absence of serotonin within the brain interferes with the ability of the HPA axis to correctly modulate the response to acute stress, by altering the nuclear mechanisms of the GR and modulation of clock genes expression. Serotonin 49-58 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 214-216 32509985-1 2020 Escitalopram (ESC), a selective serotonin reuptake inhibitor indicated for the treatment of depression and anxiety disorders, is primarily metabolized by cytochrome P450 (CYP) 2C19, which is a highly polymorphic enzyme known to cause inter-individual differences in pharmacokinetics. Serotonin 32-41 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 154-180 32486261-7 2020 Interestingly, platelet aggregation induced by co-stimulation of serotonin and epinephrine which activate Gq-coupled 5HT2A and Gz-coupled 2A adrenergic receptors, respectively, was not affected in GRK6-/- platelets, suggesting that GRK6 was involved in specific GPCR regulation. Serotonin 65-74 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 117-122 32126536-2 2020 MiR-124, widely known as a memory-related miRNA, can regulate LTM by binding to the mRNA of CREB1 stimulated with 5-HT. Serotonin 114-118 cAMP responsive element binding protein 1 Homo sapiens 92-97 32126536-3 2020 In this paper, we establish a regulatory network model of CREB1 and miR-124 stimulated by 5-HT, in which miR-124 inhibits CREB1, which in turn enhances miR-124. Serotonin 90-94 cAMP responsive element binding protein 1 Homo sapiens 58-63 32126536-3 2020 In this paper, we establish a regulatory network model of CREB1 and miR-124 stimulated by 5-HT, in which miR-124 inhibits CREB1, which in turn enhances miR-124. Serotonin 90-94 cAMP responsive element binding protein 1 Homo sapiens 122-127 32126536-7 2020 Furthermore, we specifically show a change in the transition from a reversible switch to an irreversible switch via bifurcations of the negative regulation of miR-124 on CREB1, which eventually maintains a high phosphorylated CREB1 level after initially elevated by 5-HT. Serotonin 266-270 cAMP responsive element binding protein 1 Homo sapiens 170-175 32126536-7 2020 Furthermore, we specifically show a change in the transition from a reversible switch to an irreversible switch via bifurcations of the negative regulation of miR-124 on CREB1, which eventually maintains a high phosphorylated CREB1 level after initially elevated by 5-HT. Serotonin 266-270 cAMP responsive element binding protein 1 Homo sapiens 226-231 32035145-5 2020 Electrophysiological recordings confirmed that this approach enabled reliable optogenetic stimulation of MRN 5-HT neurons, and this stimulation produced downstream 5-HT release in the dHC as measured by in vivo microdialysis. Serotonin 164-168 Dynein heavy chain 64C Drosophila melanogaster 184-187 32035145-8 2020 Stimulation of 5-HT terminals in the dHC recapitulated the anxiety-like behaviour in the novelty-suppressed feeding and marbleburying tests. Serotonin 15-19 Dynein heavy chain 64C Drosophila melanogaster 37-40 32035145-9 2020 These results show that activation of 5-HT efferents from the MRN rapidly induces expression of anxiety-like behaviour, in part via projections to the dHC. Serotonin 38-42 Dynein heavy chain 64C Drosophila melanogaster 151-154 31997472-6 2020 Furthermore, tryptophan hydroxylase 1 (TPH1), an enzyme that catalyzes the reaction of Trp to serotonin, was significantly increased in liver and spleen of AT-2 engrafted rats. Serotonin 94-103 tryptophan hydroxylase 1 Rattus norvegicus 13-37 31997472-6 2020 Furthermore, tryptophan hydroxylase 1 (TPH1), an enzyme that catalyzes the reaction of Trp to serotonin, was significantly increased in liver and spleen of AT-2 engrafted rats. Serotonin 94-103 tryptophan hydroxylase 1 Rattus norvegicus 39-43 31911191-9 2020 In summary, NP or/and OP exposure might cause anxiety-related behaviors in rats through regulating neurotransmitter 5-HT levels by altering the expression of 5-HT decomposition enzyme MAOA, transporters SERT and VMAT2, and 5-HT receptors 5-HT1A, 5-HT2A, and 5-HT2C. Serotonin 158-162 5-hydroxytryptamine receptor 2C Rattus norvegicus 258-264 31911191-9 2020 In summary, NP or/and OP exposure might cause anxiety-related behaviors in rats through regulating neurotransmitter 5-HT levels by altering the expression of 5-HT decomposition enzyme MAOA, transporters SERT and VMAT2, and 5-HT receptors 5-HT1A, 5-HT2A, and 5-HT2C. Serotonin 158-162 5-hydroxytryptamine receptor 2C Rattus norvegicus 258-264 31787571-0 2020 Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 34-39 32319618-2 2020 Colonic SERT expression is decreased in colonic sensitized rats, and the glucagon-like peptide-1 analogue, exendin-4, reduces visceral hypersensitivity by decreasing 5-HT levels and increasing SERT expression. Serotonin 166-170 glucagon Rattus norvegicus 73-96 32319618-3 2020 The present in vitro study aimed to further investigate the effects of exendin-4 on SERT expression, and to examine the role of GLP-1 and its receptor in the regulation of 5-HT. Serotonin 172-176 glucagon Rattus norvegicus 128-133 32231214-6 2020 In addition, the neurochemical profiles of GABA, glutamate, dopamine, and serotonin were disturbed and these changes also affected courtship behaviors in dUbqn-depleted flies. Serotonin 74-83 Ubiquilin Drosophila melanogaster 154-159 31520576-2 2020 Genetic variants in cytochrome P450 (CYP) (CYP2D6), dopamine receptor (DRD2, DRD3) and serotonin receptor (HTR2A, HTR2C) genes were previously associated with antipsychotic-induced hyperprolactinaemia. Serotonin 87-96 5-hydroxytryptamine receptor 2C Homo sapiens 114-119 32084491-2 2020 VMAT2 is present in the membrane of secretory vesicles and transports dopamine (DA), norepinephrine (NE), serotonin (5-HT), histamine, glutamate (Glu), and GABA into vesicles for presynaptic release. Serotonin 106-115 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 0-5 32084491-2 2020 VMAT2 is present in the membrane of secretory vesicles and transports dopamine (DA), norepinephrine (NE), serotonin (5-HT), histamine, glutamate (Glu), and GABA into vesicles for presynaptic release. Serotonin 117-121 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 0-5 32060357-3 2020 Here, we employ high-resolution time-lapse FRET imaging in neuroblastoma cells and neuronal dendrites to establish that activation of serotonin receptor 5-HT4 (5-HT4R) rapidly triggers spatially-restricted RhoA activity and G13-mediated phosphorylation of cofilin, thus locally boosting the filamentous actin fraction. Serotonin 134-143 5-hydroxytryptamine receptor 4 Homo sapiens 160-166 32116750-10 2020 In the antrum, Tas2r126 labeling was observed in serotonin-storing EC cells and ghrelin cells, both representing only minor populations of enteroendocrine cells in this compartment. Serotonin 49-58 taste receptor, type 2, member 126 Mus musculus 15-23 31806625-3 2020 Here, we report that serotonin regulates beta-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. Serotonin 21-30 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 96-101 31806625-8 2020 Thus, our results indicate that GH-GH receptor-STAT5-serotonin-HTR2B signaling plays a critical role in determining the beta-cell mass by regulating perinatal beta-cell proliferation, and defects in this pathway affect metabolic phenotypes in adults. Serotonin 53-62 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 63-68 31801810-14 2020 The expression ratios of 5-HT3A receptors and p11, a serotonin receptor-interacting protein, were higher in PSA-NCAM+/CCK+ cells than in PSA-NCAM-/CCK+ cells. Serotonin 53-62 cholecystokinin Mus musculus 118-121 31792153-5 2020 Susceptible, but not resilient, rats displayed an increased number of neurons expressing the biosynthetic enzyme for serotonin, tryptophan-hydroxylase-2 (TPH2), in the ventral subnucleus of the dorsal raphe nucleus (DRv). Serotonin 117-126 tryptophan hydroxylase 2 Rattus norvegicus 128-152 31792153-5 2020 Susceptible, but not resilient, rats displayed an increased number of neurons expressing the biosynthetic enzyme for serotonin, tryptophan-hydroxylase-2 (TPH2), in the ventral subnucleus of the dorsal raphe nucleus (DRv). Serotonin 117-126 tryptophan hydroxylase 2 Rattus norvegicus 154-158 31998441-8 2020 Serotonin significantly facilitated the release of serum and intrahepatic inflammatory cytokines, including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17A (IL-17A), interferon-gamma (IFN-gamma), and tumor necrosis-alpha (TNF-alpha), after the administration of Con A. Serotonin 0-9 interleukin 17A Mus musculus 152-167 31998441-8 2020 Serotonin significantly facilitated the release of serum and intrahepatic inflammatory cytokines, including interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-17A (IL-17A), interferon-gamma (IFN-gamma), and tumor necrosis-alpha (TNF-alpha), after the administration of Con A. Serotonin 0-9 interleukin 17A Mus musculus 169-175 31998441-9 2020 In addition, serotonin significantly increased the intrahepatic levels of oxidative stress markers malonaldehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) and decreased antioxidant stress indicator glutathione (GSH) in Con A-treated mice. Serotonin 13-22 myeloperoxidase Mus musculus 120-135 31998441-9 2020 In addition, serotonin significantly increased the intrahepatic levels of oxidative stress markers malonaldehyde (MDA), myeloperoxidase (MPO), and nitric oxide (NO) and decreased antioxidant stress indicator glutathione (GSH) in Con A-treated mice. Serotonin 13-22 myeloperoxidase Mus musculus 137-140 31998441-10 2020 Additionally, serotonin promoted hepatocyte apoptosis and autophagy based on B-cell lymphoma-2 (Bcl-2), Bcl-2-asociated X protein (Bax), and Beclin-1 levels and TUNEL staining. Serotonin 14-23 BCL2-associated X protein Mus musculus 104-129 31998441-10 2020 Additionally, serotonin promoted hepatocyte apoptosis and autophagy based on B-cell lymphoma-2 (Bcl-2), Bcl-2-asociated X protein (Bax), and Beclin-1 levels and TUNEL staining. Serotonin 14-23 BCL2-associated X protein Mus musculus 131-134 31509772-11 2019 Moreover, this study suggests that alteration of placental 5-HT levels due to depression and/or SRI treatment during pregnancy may be associated with disruption of placental estrogen production. Serotonin 59-63 sorcin Homo sapiens 96-99 31674727-5 2019 RESULTS: Nondifferentiated HIB1B brown adipocytes treated with serotonin showed increased brown adipocyte markers alongside increased brain-muscle Arnt-like protein 1 (Bmal1) and RAR related orphan receptor A (Rora) but decreased nuclear receptor Rev-erbalpha mRNA levels. Serotonin 63-72 aryl hydrocarbon receptor nuclear translocator like Homo sapiens 134-166 31674727-5 2019 RESULTS: Nondifferentiated HIB1B brown adipocytes treated with serotonin showed increased brown adipocyte markers alongside increased brain-muscle Arnt-like protein 1 (Bmal1) and RAR related orphan receptor A (Rora) but decreased nuclear receptor Rev-erbalpha mRNA levels. Serotonin 63-72 aryl hydrocarbon receptor nuclear translocator like Homo sapiens 168-173 31674727-5 2019 RESULTS: Nondifferentiated HIB1B brown adipocytes treated with serotonin showed increased brown adipocyte markers alongside increased brain-muscle Arnt-like protein 1 (Bmal1) and RAR related orphan receptor A (Rora) but decreased nuclear receptor Rev-erbalpha mRNA levels. Serotonin 63-72 RAR related orphan receptor A Homo sapiens 210-214 31674727-8 2019 After differentiation, serotonin treatment significantly decreased brown adipocyte markers and reduced BMAL1 and RORalpha but increased REV-ERBalpha protein levels. Serotonin 23-32 aryl hydrocarbon receptor nuclear translocator like Homo sapiens 103-108 31674727-8 2019 After differentiation, serotonin treatment significantly decreased brown adipocyte markers and reduced BMAL1 and RORalpha but increased REV-ERBalpha protein levels. Serotonin 23-32 RAR related orphan receptor A Homo sapiens 113-121 31674727-9 2019 Addition of serotonin to the differentiation medium or addition after differentiation reduced activity of calcium/calmodulin-dependent protein kinase type II subunit gamma, which interferes with circadian locomoter output cycles protein kaput (CLOCK):BMAL1 dimerization and transactivation. Serotonin 12-21 aryl hydrocarbon receptor nuclear translocator like Homo sapiens 251-256 31687714-5 2019 infantis strain CCFM687 could significantly enhance the biosynthesis of 5-hydroxytryptamine (5-HTP) in vitro in RIN14B cells through up-regulation of the Tph1 gene expression. Serotonin 72-91 tryptophan hydroxylase 1 Rattus norvegicus 154-158 31687714-5 2019 infantis strain CCFM687 could significantly enhance the biosynthesis of 5-hydroxytryptamine (5-HTP) in vitro in RIN14B cells through up-regulation of the Tph1 gene expression. Serotonin 93-98 tryptophan hydroxylase 1 Rattus norvegicus 154-158 31074783-1 2019 CONTEXT: In the human adrenal, serotonin (5-HT), released by mast cells stimulates corticosteroid secretion through activation of type 4 serotonin receptors (5-HT4R). Serotonin 31-40 5-hydroxytryptamine receptor 4 Homo sapiens 158-164 31074783-1 2019 CONTEXT: In the human adrenal, serotonin (5-HT), released by mast cells stimulates corticosteroid secretion through activation of type 4 serotonin receptors (5-HT4R). Serotonin 42-46 5-hydroxytryptamine receptor 4 Homo sapiens 158-164 31074783-1 2019 CONTEXT: In the human adrenal, serotonin (5-HT), released by mast cells stimulates corticosteroid secretion through activation of type 4 serotonin receptors (5-HT4R). Serotonin 137-146 5-hydroxytryptamine receptor 4 Homo sapiens 158-164 31074783-9 2019 In paraCS cultured cells, the cortisol response to 5-HT was exaggerated compared with normal adrenal cells and the stimulatory action of 5-HT was reduced by 5-HT4R antagonist. Serotonin 137-141 5-hydroxytryptamine receptor 4 Homo sapiens 157-163 29683396-3 2019 However, a clear biological framework linking dysfunctions in Trp metabolism via 5-HT and Kyn, cortisol, and the activities of tryptophan and indoleamino 2,3-dioxygenase (TDO, IDO) enzymes has not been yet clarified in MDD with or without suicidal behaviours.Methods: We analysed peripheral markers of Trp via 5-HT and Kyn pathways, Kyn/Trp ratio as a measure of TDO/IDO activities, cortisol, and psychopathology in 73 non-suicidal and 56 suicidal MDD patients, and in 40 healthy controls.Results: Plasma Trp levels were lower and the ratio Kyn/Trp higher in suicidal MDD than in non-suicidal MDD patients and controls. Serotonin 310-314 tryptophan 2,3-dioxygenase Homo sapiens 171-174 31616600-0 2019 Optimizing drug selection in psychopharmacology based on 40 significant CYP2C19- and CYP2D6-biased adverse drug reactions of selective serotonin reuptake inhibitors. Serotonin 135-144 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 72-79 31185197-8 2019 Furthermore, serotonin depletion also prevented the TBI-induced bilateral increase in c-Fos positive cells within the Rexed laminae I and II of the dorsal horns. Serotonin 13-22 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 86-91 31451801-2 2019 Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). Serotonin 43-62 somatostatin Homo sapiens 125-137 31451801-2 2019 Here we identify a novel pathway involving 5-hydroxytryptamine (5-HT) projections from the dorsal raphe nucleus (5-HTDRN) to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA). Serotonin 64-68 somatostatin Homo sapiens 125-137 30959513-0 2019 Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Serotonin 32-41 glucagon Rattus norvegicus 70-75 30959513-0 2019 Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation. Serotonin 32-41 5-hydroxytryptamine receptor 2C Rattus norvegicus 99-105 30959513-2 2019 The interaction between serotonin (5-HT) and glucagon-like peptide-1 (GLP-1) could play a role as upstream effectors involved in mediating associations between anorectic and noxious/stressful stimuli. Serotonin 24-33 glucagon Rattus norvegicus 45-68 30959513-2 2019 The interaction between serotonin (5-HT) and glucagon-like peptide-1 (GLP-1) could play a role as upstream effectors involved in mediating associations between anorectic and noxious/stressful stimuli. Serotonin 24-33 glucagon Rattus norvegicus 70-75 30959513-2 2019 The interaction between serotonin (5-HT) and glucagon-like peptide-1 (GLP-1) could play a role as upstream effectors involved in mediating associations between anorectic and noxious/stressful stimuli. Serotonin 35-39 glucagon Rattus norvegicus 70-75 31412049-5 2019 Moreover, we show that egg-laying defects in fahd-1(-) worms can be fully rescued by external dopamine administration and that depletion of fahd-1 expression induces expression of several enzymes involved in serotonin biosynthesis. Serotonin 208-217 Fumarylacetoacetate hydrolase domain-containing protein 1 Caenorhabditis elegans 140-146 31412049-6 2019 Together, our results support a role for fahd-1 in modulating serotonin levels and suggest this protein as a novel link between metabolism and neurotransmitter signaling in the nervous system. Serotonin 62-71 Fumarylacetoacetate hydrolase domain-containing protein 1 Caenorhabditis elegans 41-47 31270129-1 2019 Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4). Serotonin 231-240 solute carrier family 6 member 3 Homo sapiens 215-218 31270129-1 2019 Transporters of the solute carrier 6 (SLC6) family translocate their cognate substrate together with Na+ and Cl- Detailed kinetic models exist for the transporters of GABA (GAT1/SLC6A1) and the monoamines dopamine (DAT/SLC6A3) and serotonin (SERT/SLC6A4). Serotonin 231-240 solute carrier family 6 member 3 Homo sapiens 219-225 31150804-1 2019 Cisapride is a selective 5-hydroxytryptamine (5-HT)4 receptor (5-HT4R) agonist. Serotonin 25-44 5-hydroxytryptamine receptor 4 Homo sapiens 45-61 31150804-1 2019 Cisapride is a selective 5-hydroxytryptamine (5-HT)4 receptor (5-HT4R) agonist. Serotonin 25-44 5-hydroxytryptamine receptor 4 Homo sapiens 63-69 30513372-4 2019 In 2003 it became evident that two distinct isoforms of tryptophan hydroxylase (Tph), the rate-limiting enzyme for the synthesis of serotonin, are selectively expressed in peripheral tissues and in the CNS, with Tph2 as the brain specific isoform. Serotonin 132-141 tryptophan hydroxylase 2 Homo sapiens 212-216 30513372-6 2019 We mainly focus on the analysis of animal models generated by genetic manipulation of Tph2, in which the synthesis of brain serotonin was either reduced or disrupted. Serotonin 124-133 tryptophan hydroxylase 2 Homo sapiens 86-90 30635928-6 2019 Intra-IL GLAST or GLT-1 knockdown markedly reduced serotonin (5-HT) release in the dorsal raphe nucleus (DR) and induced an overall reduction of brain-derived neurotrophic factor (BDNF) expression in ipsilateral and contralateral hemispheres. Serotonin 51-60 solute carrier family 1 (glial high affinity glutamate transporter), member 2 Mus musculus 18-23 31133792-0 2019 Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala. Serotonin 84-93 cholecystokinin Mus musculus 18-33 31142902-7 2019 With the effect of BDNF, dopamine and serotonin play important roles on neurogenesis, survival, and synaptic plasticity. Serotonin 38-47 brain derived neurotrophic factor Homo sapiens 19-23 31019472-1 2019 Purpose: TPH2 and 5-HT2A appear to play vital roles in the homeostatic regulation of serotonin levels in the brain, their genetic variations may lead to impaired homeostatic regulation of serotonin resulting in abnormal levels of serotonin in the brain, thus predisposing individuals to MDD. Serotonin 85-94 tryptophan hydroxylase 2 Homo sapiens 9-13 31019472-1 2019 Purpose: TPH2 and 5-HT2A appear to play vital roles in the homeostatic regulation of serotonin levels in the brain, their genetic variations may lead to impaired homeostatic regulation of serotonin resulting in abnormal levels of serotonin in the brain, thus predisposing individuals to MDD. Serotonin 188-197 tryptophan hydroxylase 2 Homo sapiens 9-13 31019472-1 2019 Purpose: TPH2 and 5-HT2A appear to play vital roles in the homeostatic regulation of serotonin levels in the brain, their genetic variations may lead to impaired homeostatic regulation of serotonin resulting in abnormal levels of serotonin in the brain, thus predisposing individuals to MDD. Serotonin 188-197 tryptophan hydroxylase 2 Homo sapiens 9-13 30543903-1 2019 The 5-HT7 receptor is the most recently identified receptor subtype within a family of 5-HT receptors activated by the neurotransmitter serotonin. Serotonin 136-145 basigin Mus musculus 6-9 30792464-3 2019 Altered serotonin neurotransmission provides a plausible explanation for amygdala dysfunction in psychopathic traits and recent research suggests that this may be associated with serotonin 1B (5-HT1B) receptor function. Serotonin 8-17 5-hydroxytryptamine receptor 1B Rattus norvegicus 193-199 30793039-1 2019 The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors (5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular signaling domain. Serotonin 72-81 vomeronasal 1 receptor 17 pseudogene Homo sapiens 55-59 30793039-1 2019 The signal specificity of G protein-coupled receptors (GPCRs) including serotonin receptors (5-HT-R) depends on the trafficking and localization of the GPCR within its subcellular signaling domain. Serotonin 93-97 vomeronasal 1 receptor 17 pseudogene Homo sapiens 55-59 30586717-5 2019 RESULTS: Platelet-derived serotonin induced neutrophil degranulation with release of myeloperoxidase and hydrogen peroxide (H2O2) and increased expression of membrane-bound leukocyte adhesion molecule CD11b, leading to enhanced inflammation in the infarct area and reduced myocardial salvage. Serotonin 26-35 integrin subunit alpha M Homo sapiens 201-206 30586717-6 2019 In patients hospitalized with acute coronary syndrome, plasmatic serotonin levels correlated with CD11b expression on neutrophils and myeloperoxidase plasma levels. Serotonin 65-74 integrin subunit alpha M Homo sapiens 98-103 30586717-9 2019 In line, patients with depression using serotonin reuptake inhibition, presented with suppressed levels of CD11b surface expression on neutrophils and lower myeloperoxidase levels in blood. Serotonin 40-49 integrin subunit alpha M Homo sapiens 107-112 30827242-3 2019 In addition, tryptophan hydroxylase-2 (Tph2), a second tryptophan hydroxylase isoform, controls brain serotonin synthesis. Serotonin 102-111 tryptophan hydroxylase 2 Homo sapiens 39-43 30468670-5 2019 Peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (Tph), which exists in two different isoforms: Tph2 being responsible for serotonin synthesis in neurons and Tph1 for generation of serotonin in peripheral organs. Serotonin 11-20 tryptophan hydroxylase 2 Homo sapiens 120-124 30468670-5 2019 Peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (Tph), which exists in two different isoforms: Tph2 being responsible for serotonin synthesis in neurons and Tph1 for generation of serotonin in peripheral organs. Serotonin 147-156 tryptophan hydroxylase 2 Homo sapiens 120-124 30468670-5 2019 Peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (Tph), which exists in two different isoforms: Tph2 being responsible for serotonin synthesis in neurons and Tph1 for generation of serotonin in peripheral organs. Serotonin 147-156 tryptophan hydroxylase 2 Homo sapiens 120-124 30419272-0 2019 Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin. Serotonin 171-180 5-hydroxytryptamine receptor 2C Rattus norvegicus 181-187 30419272-8 2019 Serotonin through its actions on 5-HT2C receptors has been shown to play a key role in modulating the reinforcement of addictive drugs, including nicotine and alcohol. Serotonin 0-9 5-hydroxytryptamine receptor 2C Rattus norvegicus 33-39 30618598-8 2018 Agonist stimulation of 5-HT2B receptors mimicked behavioral and neurogenic SSRI actions, and increased extracellular serotonin in dorsal raphe. Serotonin 117-126 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 23-29 30355630-11 2018 Therefore, descending 5-HT sensitize PKCgamma interneurons, a putative "gate" in allodynia circuits, via 5-HT2A receptor-induced structural reorganization. Serotonin 22-26 protein kinase C, gamma Rattus norvegicus 37-45 29800645-0 2018 Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats. Serotonin 38-47 brain-derived neurotrophic factor Rattus norvegicus 33-37 28963041-7 2018 The molecular mechanism triggering respective changes in ER stress markers in these brain regions is likely related to altered levels of monoamine neurotransmitters (serotonin, dopamine) in Wfs1KO mice. Serotonin 166-175 wolframin ER transmembrane glycoprotein Mus musculus 190-196 30243647-13 2018 SIGNIFICANCE: According to these results, it may be suggested that curcumin exerts anticonvulsive effects by increasing the serotonin levels in the brain that influence receptors, including 5-HT1A, 5-HT2C, and 5-HT4 and likely through the reduction of 5-HT7 gene expression. Serotonin 124-133 basigin Mus musculus 254-257 29908119-9 2018 Together, these findings suggest that ASM-inhibiting antidepressants, including a fraction of the serotonin re-uptake inhibitors (SSRIs), are moderately immunosuppressive and should be considered for the therapy of inflammatory and autoimmune disorders. Serotonin 98-107 sphingomyelin phosphodiesterase 1, acid lysosomal Mus musculus 38-41 29969651-6 2018 The pituitary expression of the 5HT2C mRNA may constitute a previously unknown mechanism whereby serotonin in the circulation or drugs targeting the 5HT2C might induce side-effects. Serotonin 97-106 5-hydroxytryptamine receptor 2C Homo sapiens 32-37 29969651-6 2018 The pituitary expression of the 5HT2C mRNA may constitute a previously unknown mechanism whereby serotonin in the circulation or drugs targeting the 5HT2C might induce side-effects. Serotonin 97-106 5-hydroxytryptamine receptor 2C Homo sapiens 149-154 29750841-0 2018 High Serum Serotonin Predicts Increased Risk for Hip Fracture and Nonvertebral Osteoporotic Fractures: The MrOS Sweden Study. Serotonin 11-20 MROS Homo sapiens 107-111 29775696-1 2018 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin synthesis. Serotonin 69-78 tryptophan hydroxylase 2 Homo sapiens 0-24 29775696-1 2018 Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin synthesis. Serotonin 69-78 tryptophan hydroxylase 2 Homo sapiens 26-30 29775696-9 2018 Characterizing how exactly the different TPH2 variants influence the serotonergic neurotransmission is a next necessary step in understanding the psychiatric disorders where serotonin is implicated. Serotonin 174-183 tryptophan hydroxylase 2 Homo sapiens 41-45 30186170-8 2018 A subsequent validation showed that the serum level of superoxide dismutase and catalase were indeed up-regulated, while the serotonin level in a tryptophan hydroxylase 1 (TPH1) high expressing cells (rats RBL-2H3 cells) was down regulated after treatment with SWR. Serotonin 125-134 tryptophan hydroxylase 1 Rattus norvegicus 146-170 30186170-8 2018 A subsequent validation showed that the serum level of superoxide dismutase and catalase were indeed up-regulated, while the serotonin level in a tryptophan hydroxylase 1 (TPH1) high expressing cells (rats RBL-2H3 cells) was down regulated after treatment with SWR. Serotonin 125-134 tryptophan hydroxylase 1 Rattus norvegicus 172-176 29719048-0 2018 Serotonin decreases the production of Th1/Th17 cytokines and elevates the frequency of regulatory CD4+ T-cell subsets in multiple sclerosis patients. Serotonin 0-9 negative elongation factor complex member C/D Homo sapiens 38-41 29373946-9 2018 Treatment with RB1 also resulted in an increase in serotonin eight days post-treatment in chronically injured spinal cords. Serotonin 51-60 RB transcriptional corepressor 1 Rattus norvegicus 15-18 29972203-8 2018 Incubation with the RAGE antagonist FPS-ZM1 abolished the effect of AGE-BSA on serotonin release, while no impact on CML-induced serotonin release was observed. Serotonin 79-88 long intergenic non-protein coding RNA 914 Homo sapiens 20-24 29281252-3 2018 Combining the acridone fluorophore with the ethylamine recognition element of serotonin, we identified FFN54 and FFN246 as substrates for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2). Serotonin 78-87 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 177-210 29281252-3 2018 Combining the acridone fluorophore with the ethylamine recognition element of serotonin, we identified FFN54 and FFN246 as substrates for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2). Serotonin 78-87 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 212-217 28540658-6 2018 DYRK1A overexpression induced dramatic deficits in the serotonin contents of the four brain areas tested and major deficits in dopamine and adrenaline contents especially in the hypothalamus. Serotonin 55-64 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a Mus musculus 0-6 29044927-14 2018 The decreased levels of dopamine and serotonin provide the first direct evidence that knockout of HRH3 alters these systems. Serotonin 37-46 histamine receptor H3 Danio rerio 98-102 29052845-7 2018 Co-incubation with the RAGE antagonist FPS-ZM1 reduced CML-induced serotonin release by 34%, suggesting a RAGE-mediated mechanism. Serotonin 67-76 long intergenic non-protein coding RNA 914 Homo sapiens 23-27 29052845-7 2018 Co-incubation with the RAGE antagonist FPS-ZM1 reduced CML-induced serotonin release by 34%, suggesting a RAGE-mediated mechanism. Serotonin 67-76 long intergenic non-protein coding RNA 914 Homo sapiens 106-110 29131485-8 2018 Moreover, serotonin increased the expression of SIRT-1 and 2, heat shock protein 70, and heme oxygenase activity, this being a possible mechanism underlying the observed neuroprotective effect. Serotonin 10-19 sirtuin 1 Homo sapiens 48-60 29924134-1 2018 Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Serotonin 47-56 5-hydroxytryptamine receptor 2C Homo sapiens 24-29 29246092-0 2018 Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome. Serotonin 45-54 p21 (RAC1) activated kinase 3 Homo sapiens 106-110 28899958-4 2018 Availability of DAT and SERT may thus provide an in vivo measure for the integrity of both dopamine and serotonin neurons. Serotonin 104-113 solute carrier family 6 member 3 Homo sapiens 16-19 29258493-10 2017 PM21 increased intracellular cAMP level and reduced the release of ATP, TXA2, and serotonin. Serotonin 82-91 2-oxoglutarate-dependent dioxygenase DAO-like Prunus mume 0-4 29054488-5 2017 Jmjd2a responded to 5-hydroxytryptamine (5-HT) and promoted the expression of the brain-derived neurotrophic factor (Bdnf), which is a protein critically involved in neuropathic pain. Serotonin 20-39 lysine (K)-specific demethylase 4A Mus musculus 0-6 29123193-7 2017 WAP-Cre x Lrp5 FL/FL dams had elevated serotonin concentrations in both the mammary gland and circulation compared to controls. Serotonin 39-48 whey acidic protein Mus musculus 0-3 29123193-8 2017 In contrast, WAP-Cre x Tph1 FL/FL dams had decreased mammary gland and serum serotonin concentrations compared to controls. Serotonin 77-86 whey acidic protein Mus musculus 13-16 28774871-9 2017 Moreover, we suggest that mucosally restricted inhibition of 5-HT biosynthesis and/or administration of OT may be useful in the treatment of NEC.NEW & NOTEWORTHY Serotonin (5-HT) and oxytocin reciprocally regulate the severity of intestinal inflammation and hepatotoxicity in a murine model of necrotizing enterocolitis (NEC). Serotonin 166-175 oxytocin Mus musculus 187-195 28942992-0 2017 A new Drosophila octopamine receptor responds to serotonin. Serotonin 49-58 Octopamine receptor in mushroom bodies Drosophila melanogaster 17-36 28856708-10 2017 INTERPRETATION: Degeneration of serotonin neurons is necessary to trigger spasticity through the 5-HT2B/C receptor. Serotonin 32-41 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 97-103 28464229-1 2017 Tryptophan hydroxylase 2 (TPH2) is the key enzyme in the synthesis of neuronal serotonin. Serotonin 79-88 tryptophan hydroxylase 2 Rattus norvegicus 0-24 28464229-1 2017 Tryptophan hydroxylase 2 (TPH2) is the key enzyme in the synthesis of neuronal serotonin. Serotonin 79-88 tryptophan hydroxylase 2 Rattus norvegicus 26-30 28714031-5 2017 The findings demonstrated that the NL cells produced by neuritin treatment expressed the neuronal markers neuron-specific enolase and microtubule associate protein 2, and secreted the neurotransmitter 5-hydroxytryptamine. Serotonin 201-220 neuritin 1 Rattus norvegicus 56-64 28754344-0 2017 The effect of childhood trauma on serum BDNF in bipolar depression is modulated by the serotonin promoter genotype. Serotonin 87-96 brain derived neurotrophic factor Homo sapiens 40-44 28915571-9 2017 Furthermore, p62 plasmid partially restored levels of the satiety hormone, serotonin, and tryptophan, simultaneously reducing activity of monoamine oxidase (MAO) in the brain affected by the HCD. Serotonin 75-84 sequestosome 1 Homo sapiens 13-16 28461009-10 2017 Moreover, female homozygous VAChT KD mice exhibited higher levels of dopamine and serotonin in the striatum, and increased dopamine in the hippocampus. Serotonin 82-91 solute carrier family 18 (vesicular monoamine), member 3 Mus musculus 28-33 28607170-10 2017 Our results show that oxytocin administration in nonhuman primates influences serotoninergic neurotransmission via at least two ways: (1) by provoking a release of serotonin in key limbic regions; and (2) by increasing the availability of 5-HT1AR receptors in the same limbic areas. Serotonin 78-87 oxytocin/neurophysin I prepropeptide Homo sapiens 22-30 28607170-11 2017 Because these two molecules are important for social behavior, our study sheds light on the specific nature of their interaction, therefore helping to develop new mechanisms-based therapies for psychiatric disorders.SIGNIFICANCE STATEMENT Social behavior is largely controlled by brain neuromodulators, such as oxytocin and serotonin. Serotonin 324-333 oxytocin/neurophysin I prepropeptide Homo sapiens 311-319 28607170-14 2017 We found that oxytocin provokes the release of serotonin, which in turn impacts on the serotonin 1A receptor system, by modulating its availability. Serotonin 47-56 oxytocin/neurophysin I prepropeptide Homo sapiens 14-22 27938488-8 2017 Interestingly, coexpression of TH and serotonin was found to be dependent on the time in culture, the plating density, and the exposure to neurotrophic factors, that is, higher cell densities and treatment with brain-derived neurotrophic factor resulted in a significantly reduced coexpression rate. Serotonin 38-47 brain-derived neurotrophic factor Rattus norvegicus 211-244 28443016-5 2017 Interestingly, (i) the expression of three of these six genes (COMT, DBH, NOS1) are highly variable; (ii) three of these six genes (COMT, DBH, TPH1) are involved in DA or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (AR, BDNF, COMT, DBH, NOS1) have been implicated in the development, onset and/or propagation of schizophrenia. Serotonin 171-180 brain derived neurotrophic factor Homo sapiens 271-275 28057699-0 2017 Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight. Serotonin 85-94 glucagon Rattus norvegicus 0-23 28057699-5 2017 Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin 0-9 glucagon Rattus norvegicus 73-78 28057699-5 2017 Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin 0-9 glucagon-like peptide 1 receptor Rattus norvegicus 199-213 28057699-5 2017 Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin 0-9 glucagon-like peptide 1 receptor Rattus norvegicus 215-221 28057699-5 2017 Serotonin depletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that serotonin is a critical mediator of the energy balance impact of GLP-1 receptor (GLP-1R) activation. Serotonin 134-143 glucagon-like peptide 1 receptor Rattus norvegicus 199-213 27869544-1 2017 Dopa decarboxylase (DDC) protein is involved in the synthesis of dopamine and serotonin. Serotonin 78-87 aromatic-L-amino-acid decarboxylase Bombyx mori 0-18 27869544-1 2017 Dopa decarboxylase (DDC) protein is involved in the synthesis of dopamine and serotonin. Serotonin 78-87 aromatic-L-amino-acid decarboxylase Bombyx mori 20-23 28144708-10 2017 Although preliminary, the results may indicate that disrupted serotonin signaling produces a vulnerability to undesirable effects of CB1 inverse agonists, which is not evident in the general population. Serotonin 62-71 cannabinoid receptor 1 Rattus norvegicus 133-136 27743931-4 2017 KOR agonists modulate serotonin (5-HT) transmission in the brain regions implicated in mood and motivation regulation. Serotonin 22-31 opioid receptor kappa 1 Homo sapiens 0-3 28245760-7 2017 The CRF-R2 mediated inhibition of antral and corpus contractility involves a direct action on gastric myenteric neurons where CRF-R2 is expressed and may also involve the activation of serotonin acting on 5-HT3 receptor. Serotonin 185-194 corticotropin releasing hormone receptor 2 Rattus norvegicus 4-10 27686964-3 2016 Serotonin plays important roles in alveolar macrophages function through 5-HT2C receptors activation. Serotonin 0-9 5-hydroxytryptamine receptor 2C Rattus norvegicus 73-79 27899892-5 2016 We found a statistically significant increase (nominal p < 0.05) in the expression of UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT2B7, and UGT2B17, as well as glucuronidation activities of serotonin, testosterone, and vorinostat during the first 25 years of life. Serotonin 191-200 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 89-95 27899892-5 2016 We found a statistically significant increase (nominal p < 0.05) in the expression of UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT2B7, and UGT2B17, as well as glucuronidation activities of serotonin, testosterone, and vorinostat during the first 25 years of life. Serotonin 191-200 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 97-103 27899892-5 2016 We found a statistically significant increase (nominal p < 0.05) in the expression of UGT1A1, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT2B7, and UGT2B17, as well as glucuronidation activities of serotonin, testosterone, and vorinostat during the first 25 years of life. Serotonin 191-200 UDP glucuronosyltransferase family 2 member B7 Homo sapiens 129-135 27503749-3 2016 Benzylamine and serotonin oxidation were catalyzed by MAO-B and MAO-A, respectively, to aldehydes. Serotonin 16-25 monoamine oxidase B Rattus norvegicus 54-59 27562857-14 2016 A significantly lower percentage of serotonin with CTB double-labeled neurons in CTB-labeled neurons was demonstrated after ovariectomy, and both estradiol and Remifemin countered this OVX-induced decrease. Serotonin 36-45 phosphate cytidylyltransferase 1B, choline Rattus norvegicus 51-54 27562857-14 2016 A significantly lower percentage of serotonin with CTB double-labeled neurons in CTB-labeled neurons was demonstrated after ovariectomy, and both estradiol and Remifemin countered this OVX-induced decrease. Serotonin 36-45 phosphate cytidylyltransferase 1B, choline Rattus norvegicus 81-84 26616386-14 2016 There is insufficient knowledge of how oxytocin interacts with vasopressin, testosterone, dopamine, and serotonin, which are also important key players in the experience of social reward and stress responsivity. Serotonin 104-113 oxytocin/neurophysin I prepropeptide Homo sapiens 39-47 27191890-8 2016 The correlations between genetic variants of the HCRTR1 gene, the polymorphism 5-HTTLPR and hypocretin-1, and serotonin were observed. Serotonin 110-119 hypocretin receptor 1 Homo sapiens 49-55 27208490-1 2016 Amphetamine withdrawal is associated with heightened anxiety-like behavior, which is directly driven by blunted stress-induced glucocorticoid receptor-dependent serotonin release in the ventral hippocampus. Serotonin 161-170 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 127-150 27444653-1 2016 The biogenic amine serotonin (5-HT) is a multi-faceted hormone that is synthesized from dietary tryptophan with the rate limiting step being catalyzed by the enzyme tryptophan hydroxylase (TPH). Serotonin 19-28 tryptophan hydroxylase 1 Rattus norvegicus 165-187 27444653-1 2016 The biogenic amine serotonin (5-HT) is a multi-faceted hormone that is synthesized from dietary tryptophan with the rate limiting step being catalyzed by the enzyme tryptophan hydroxylase (TPH). Serotonin 19-28 tryptophan hydroxylase 1 Rattus norvegicus 189-192 26935476-7 2016 CONCLUSION: A maternal vitamin B6 -deficient diet affects the expression of genes related to GABA, glutamate, and serotonin metabolisms in offspring by regulating Gad1, Glul, Gls, and Tph1 mRNA expression. Serotonin 114-123 glutamate-ammonia ligase Rattus norvegicus 169-173 26935476-7 2016 CONCLUSION: A maternal vitamin B6 -deficient diet affects the expression of genes related to GABA, glutamate, and serotonin metabolisms in offspring by regulating Gad1, Glul, Gls, and Tph1 mRNA expression. Serotonin 114-123 tryptophan hydroxylase 1 Rattus norvegicus 184-188 26894483-3 2016 Here, we investigated in healthy individuals if cerebral serotonin 4 receptor (5-HT4r) binding, reported to be a proxy for serotonin levels, is associated with CAR. Serotonin 57-66 5-hydroxytryptamine receptor 4 Homo sapiens 79-85 26894483-10 2016 We suggest that higher synaptic serotonin concentration, here indexed by lower 5-HT4r binding, supports HPA-axis dynamics, which in healthy volunteers is reflected by a robust CAR. Serotonin 32-41 5-hydroxytryptamine receptor 4 Homo sapiens 79-85 26699077-11 2016 Serotonin was further shown to prevent the loss of cells and cellular alpha-ketoglutarate dehydrogenase complex activity caused by HOCl. Serotonin 0-9 oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) Mus musculus 70-103 26920358-0 2016 Serotonin-to-dopamine transporter ratios in Parkinson disease: Relevance for dyskinesias. Serotonin 0-9 solute carrier family 6 member 3 Homo sapiens 13-33 26920358-9 2016 CONCLUSIONS: Serotonin-to-dopamine transporter binding ratio increases as PD progresses and patients experience LIDs. Serotonin 13-22 solute carrier family 6 member 3 Homo sapiens 26-46 26365518-2 2016 Tryptophan hydroxylase-2 (TPH2) is an important rate-limiting enzyme in the synthetic pathway for brain serotonin and has been suggested to play a role in BD. Serotonin 104-113 tryptophan hydroxylase 2 Homo sapiens 0-24 26365518-2 2016 Tryptophan hydroxylase-2 (TPH2) is an important rate-limiting enzyme in the synthetic pathway for brain serotonin and has been suggested to play a role in BD. Serotonin 104-113 tryptophan hydroxylase 2 Homo sapiens 26-30 27021111-6 2016 Furthermore, oxytocin evened the revealed asymmetry in serotonin and 5-hydroxyindoleacetic acid concentrations in the hippocampus. Serotonin 55-64 oxytocin Mus musculus 13-21 26724568-8 2016 Acute central GLP-1 receptor stimulation also altered serotonin signaling in the amygdala. Serotonin 54-63 glucagon-like peptide 1 receptor Rattus norvegicus 14-28 26724568-11 2016 Collectively we show a striking impact of central GLP-1 on emotionality and the amygdala serotonin signaling that is divergent under acute versus chronic GLP-1 activation conditions. Serotonin 89-98 glucagon Rattus norvegicus 154-159 27162617-4 2016 We hypothesized that an increase in intracellular serotonin via increased SERT expression may dysregulate estrogen metabolism via CYP1B1 to facilitate PAH. Serotonin 50-59 cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus 130-136 26373539-6 2016 In contrast, dopamine (DA)- and serotonin (5HT)-induced S(35)-GTPgammaS binding to Galphas/olf and Galphaq/11 were significantly increased in schizophrenia cases, while these parameters were strikingly reduced by in vitro treatment with antipsychotics. Serotonin 32-41 transmembrane O-mannosyltransferase targeting cadherins 1 Homo sapiens 91-94 26373539-6 2016 In contrast, dopamine (DA)- and serotonin (5HT)-induced S(35)-GTPgammaS binding to Galphas/olf and Galphaq/11 were significantly increased in schizophrenia cases, while these parameters were strikingly reduced by in vitro treatment with antipsychotics. Serotonin 43-46 transmembrane O-mannosyltransferase targeting cadherins 1 Homo sapiens 91-94 26901633-12 2016 In conclusion, our results demonstrate an original inhibition of serotonin synthesis by GCs, both in basal condition and after stimulation by prolactin or activators of the GLP-1 receptor. Serotonin 65-74 glucagon-like peptide 1 receptor Mus musculus 173-187 26809779-6 2016 A number of common genes were identified as differentially methylated in schizophrenia/bipolar disorder, which were related to reelin, brain-derived neurotrophic factor, dopamine (including the catechol-O-methyltransferase gene), serotonin and glutamate, despite inconsistent findings of hyper-, hypo-, or lack of methylation at these and other loci. Serotonin 230-239 reelin Homo sapiens 127-133 26730407-6 2015 Furthermore, putative serotonin neurons exhibit an increase in both excitatory and GABAA receptor-mediated spontaneous postsynaptic currents during this developmental period. Serotonin 22-31 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 Mus musculus 83-88 27069689-6 2016 Single nucleotide polymorphisms in the SLC6A4, TPH2, and GALM genes may affect the activity of serotonin and increase the risk of HAND. Serotonin 95-104 tryptophan hydroxylase 2 Homo sapiens 47-51 26454419-0 2016 Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Serotonin 91-100 corticotropin releasing hormone receptor 1 Rattus norvegicus 37-42 26454419-0 2016 Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Serotonin 91-100 corticotropin releasing hormone receptor 2 Rattus norvegicus 47-52 26454419-1 2016 Anxiety and affective disorders are often associated with hypercortisolism and dysfunctional serotonergic systems, including increased expression of TPH2, the gene encoding the rate-limiting enzyme of neuronal serotonin synthesis. Serotonin 210-219 tryptophan hydroxylase 2 Rattus norvegicus 149-153 26454419-10 2016 Our data demonstrate that chronically elevated glucocorticoids sensitize stress- and anxiety-related serotonergic systems, and for the first time reveal competing roles of CRHR1 and CRHR2 on stress-induced in vivo serotonin synthesis. Serotonin 214-223 corticotropin releasing hormone receptor 1 Rattus norvegicus 172-177 26454419-10 2016 Our data demonstrate that chronically elevated glucocorticoids sensitize stress- and anxiety-related serotonergic systems, and for the first time reveal competing roles of CRHR1 and CRHR2 on stress-induced in vivo serotonin synthesis. Serotonin 214-223 corticotropin releasing hormone receptor 2 Rattus norvegicus 182-187 26376956-6 2015 serotonin (5-HT), due to genetic alteration in key enzyme MTHFR in the homocysteine metabolism pathway that leads to depression. Serotonin 0-9 methylenetetrahydrofolate reductase Homo sapiens 58-63 27004312-3 2015 CASE REPORT: The authors reported a case of serotonin syndrome associated with combined therapy of monoamine oxidase-B inhibitors and selective serotonin reuptake inhibitor A 77-year-old Thai man had been taking escitalopram for depression for three years. Serotonin 44-53 monoamine oxidase B Homo sapiens 99-118 26460149-9 2015 Selective antagonists for 5-HT1B, 5-HT2A, 5-HT3 receptors at doses of 0.1, 1 and 10 microg, reversed the antihyperalgesic effect induced by 250 ng serotonin. Serotonin 147-156 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 34-40 26352512-0 2015 Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells. Serotonin 49-58 chromogranin A Mus musculus 21-35 26557063-7 2015 We discovered that injections of the neurotoxins 5,6/5,7-DHT as well as serotonin, caused a decrease in the resting and threshold potentials of the premotor interneurons LPa3 and RPa3. Serotonin 72-81 replication protein A3 Homo sapiens 179-183 26243683-7 2015 Furthermore, serotonin regulates diet intake, leptin, corticosterone, inflammatory mechanisms, altered plasma glucose, insulin resistance and BDNF concentration in brain. Serotonin 13-22 brain derived neurotrophic factor Homo sapiens 142-146 26370232-9 2015 Furthermore, we found that PP2-expressing cells contain serotonin and aanat2, the key enzyme involved in melatonin synthesis from serotonin, whereas PP1-expressing cells do not contain either, suggesting that blue-sensitive PP2 is instead involved in light-regulation of melatonin secretion. Serotonin 130-139 arylalkylamine N-acetyltransferase 2 Danio rerio 70-76 26071405-3 2015 Brain TPH2 mRNA, encoding the rate-limiting enzyme in serotonin synthesis, was induced 2.2-fold by 10 nM 1,25D in human U87 glioblastoma cells and 47.8-fold in rat serotonergic RN46A-B14 cells. Serotonin 54-63 TPH2 Bos taurus 6-10 26215117-3 2015 PCB 153 exposure at p8, p14 and p20 had no effects on levels of these transmitters when examined at p55, but led to increased levels of both homovanillic acid and 5-hydroxyindoleacetic acid, the degradation products of dopamine and serotonin, respectively, in all groups except the female SHR. Serotonin 232-241 pyruvate carboxylase Rattus norvegicus 0-3 25930119-1 2015 Tryptophan hydroxylase 1 (Tph-1) initiates the biosynthesis of peripheral serotonin. Serotonin 74-83 tryptophan hydroxylase 1 Rattus norvegicus 0-24 25930119-1 2015 Tryptophan hydroxylase 1 (Tph-1) initiates the biosynthesis of peripheral serotonin. Serotonin 74-83 tryptophan hydroxylase 1 Rattus norvegicus 26-31 25930119-2 2015 As peripheral serotonin suppresses bone formation, inhibitor of Tph-1 provides a useful tool to discover anabolic agents for osteoporosis. Serotonin 14-23 tryptophan hydroxylase 1 Rattus norvegicus 64-69 25642596-0 2015 Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. Serotonin 76-85 solute carrier family 22 member 3 Homo sapiens 47-54 25642596-1 2015 Coordinated serotonin (5-HT) synthesis and reuptake depends on coexpression of Tph2, Aadc (Ddc), and Sert (Slc6a4) in brain 5-HT neurons. Serotonin 12-21 tryptophan hydroxylase 2 Homo sapiens 79-83 25857335-0 2015 Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 48-54 25857335-7 2015 We found expression of the serotonin 5-HT2B receptor on postnatal microglia, suggesting that serotonin could participate in temporal and spatial synchronization of microglial functions. Serotonin 27-36 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 37-43 25857335-8 2015 Using two-photon microscopy, acute brain slices, and local delivery of serotonin, we observed that microglial processes moved rapidly toward the source of serotonin in Htr2B(+/+) mice, but not in Htr2B(-/-) mice lacking the 5-HT2B receptor. Serotonin 155-164 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 168-173 26074006-5 2015 In addition, acute itch triggered by serotonin or a selective serotonin reuptake inhibitor required both HTR7 and TRPA1. Serotonin 37-46 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 114-119 25865680-7 2015 Moreover, Gongjin-Dan considerably normalized the forced running stress-induced changes in serum corticosterone and adrenaline levels, as well as brain serotonin level. Serotonin 152-161 NBL1, DAN family BMP antagonist Mus musculus 18-21 25713056-5 2015 Brain serotonin is synthesized from tryptophan by tryptophan hydroxylase 2, which is transcriptionally activated by vitamin D hormone. Serotonin 6-15 tryptophan hydroxylase 2 Homo sapiens 50-74 25903497-8 2015 We show that serotonin-increased feeding leads to increased protein synthesis in a SER-7-dependent manner, including proteins known to promote aging. Serotonin 13-22 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 83-88 25720309-2 2015 The neurotransmitter serotonin is distinguished as food intake mediator; within its multiples receptors, the 5-HT2C type is characterized by its inhibitory appetite action but there is no information about 5-HT5A receptors involvement in obesity disease. Serotonin 21-30 5-hydroxytryptamine receptor 2C Rattus norvegicus 109-115 25849355-5 2015 Thus, endocytosis resulting from the simultaneous activation of co-expressed MOP and serotonin 5-HT2C receptors by morphine plus serotonin was significantly different, in kinetics as well as in maximal response parameters, from the one caused by DAMGO, sufentanyl or methadone. Serotonin 85-94 5-hydroxytryptamine receptor 2C Homo sapiens 95-101 25773907-0 2015 New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Serotonin 122-131 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 140-146 25773907-0 2015 New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors. Serotonin 122-131 basigin Mus musculus 150-153 25532499-1 2015 BACKGROUND: Serotonin (5-HT) release and serotonin reuptake transporter (5-HTT) expression have been reported to be decreased in experimental colitis, in interleukin-10 knockout-associated colitis, and in patients with ulcerative colitis. Serotonin 12-21 interleukin 10 Homo sapiens 154-168 25747464-10 2015 Such an effect might be caused by the influence of DHEAS on serotonin neurotransmission, as this steroid decreased serotonin concentration and turnover in the striatum. Serotonin 60-69 sulfotransferase family 2A member 1 Homo sapiens 51-56 25747464-10 2015 Such an effect might be caused by the influence of DHEAS on serotonin neurotransmission, as this steroid decreased serotonin concentration and turnover in the striatum. Serotonin 115-124 sulfotransferase family 2A member 1 Homo sapiens 51-56 25747464-11 2015 When DHEAS and cocaine were administered together, the levels of serotonin in the striatum and hippocampus remained unchanged. Serotonin 65-74 sulfotransferase family 2A member 1 Homo sapiens 5-10 25455586-1 2015 The tryptophan hydroxylase-2 gene (TPH2) is coding for the key enzyme of serotonin (5-HT) synthesis in the brain and has been associated with a number of psychiatric conditions. Serotonin 73-82 tryptophan hydroxylase 2 Homo sapiens 4-28 25455586-1 2015 The tryptophan hydroxylase-2 gene (TPH2) is coding for the key enzyme of serotonin (5-HT) synthesis in the brain and has been associated with a number of psychiatric conditions. Serotonin 73-82 tryptophan hydroxylase 2 Homo sapiens 35-39 25616063-0 2015 Is the increased presence of CD8 T-lymphocytes related to serotonin levels in Chagas disease? Serotonin 58-67 CD8a molecule Homo sapiens 29-32 25445491-10 2015 In addition to these brain effects, n-3 LCPUFA supplementation reduced the allergic skin response and restored decreased intestinal levels of serotonin metabolite 5-hydroxyindoleacetic acid in allergic mice. Serotonin 142-151 notch 3 Mus musculus 36-39 25019941-8 2015 Thus, CAII may play a critical role in NET lung tumor growth, angiogenesis, and survival, possibly via 5-hydroxytryptamine, known to drive autocrine tumor growth. Serotonin 103-122 carbonic anhydrase 2 Homo sapiens 6-10 25153685-6 2015 We also observed that siRNA-mediated silencing of phosducin gene expression decreased Ca(2+)-stimulated secretion of calcitonin and serotonin by TT cells. Serotonin 132-141 phosducin Homo sapiens 50-59 24872079-0 2015 Endogenous serotonin facilitates hippocampal long-term potentiation at CA3/CA1 synapses. Serotonin 11-20 carbonic anhydrase 3 Rattus norvegicus 71-74 24826915-4 2015 REMSD triggered antidepressant mechanisms such as the increment of brain-derived neurotrophic factor (BDNF) levels, within the substantia nigra pars compacta (SNpc), which were strongly correlated to the swimming time (r = 0.83; P < 0.0001) and hippocampal serotonin (5-HT) content (r = 0.66; P = 0.004). Serotonin 260-269 brain derived neurotrophic factor Homo sapiens 67-100 24826915-4 2015 REMSD triggered antidepressant mechanisms such as the increment of brain-derived neurotrophic factor (BDNF) levels, within the substantia nigra pars compacta (SNpc), which were strongly correlated to the swimming time (r = 0.83; P < 0.0001) and hippocampal serotonin (5-HT) content (r = 0.66; P = 0.004). Serotonin 260-269 brain derived neurotrophic factor Homo sapiens 102-106 25286119-2 2015 Although FADD was shown to participate in receptor mechanisms related to drugs of abuse, little is known on its role in the signaling of classic neurotransmitters (dopamine, noradrenaline, and serotonin) in brain. Serotonin 193-202 Fas associated via death domain Rattus norvegicus 9-13 25218306-0 2014 VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems. Serotonin 77-86 vascular endothelial growth factor A Mus musculus 0-4 25218306-7 2014 However, we found imbalances in brain monoamine contents, in which the levels of norepinephrine and serotonin, but not dopamine, were decreased exclusively in the regions where VEGF was expressed. Serotonin 100-109 vascular endothelial growth factor A Mus musculus 177-181 25218306-12 2014 These data suggest that VEGF-induced antidepressant-like effects involve modulation of norepinephrine and serotonin systems. Serotonin 106-115 vascular endothelial growth factor A Mus musculus 24-28 25427177-6 2014 The monoamine uptake inhibition activity in the cloned human transporters expressed in HEK-293 cells (70.4, 9.18 and 39.7 for DAT, SERT and NET, respectively) indicates a serotonin preferring triple reuptake inhibition profile for this drug. Serotonin 171-180 solute carrier family 6 member 3 Homo sapiens 126-129 25214396-7 2014 Gene ablation of Isl1 in the intestine results in loss of GLP-1, GIP, cholecystokinin (CCK), and somatostatin-expressing cells and an increase in 5-HT (serotonin)-producing cells, while the chromogranin A population was unchanged. Serotonin 152-161 ISL1 transcription factor, LIM/homeodomain Mus musculus 17-21 25214390-3 2014 As a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (TPH2) represents a plausible candidate gene. Serotonin 29-38 tryptophan hydroxylase 2 Homo sapiens 63-87 25214390-3 2014 As a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (TPH2) represents a plausible candidate gene. Serotonin 29-38 tryptophan hydroxylase 2 Homo sapiens 89-93 24947465-2 2014 In particular, it bound with high affinity (Ki < 1 nM) to human serotonin 1A (h5-HT1A)-, h5-HT2A-, long form of human D2 (hD2L)-, halpha1B-, and halpha2C-adrenergic receptors. Serotonin 67-76 immunoglobulin heavy diversity 2-15 Homo sapiens 121-123 25238823-5 2014 The expression of enzymes involved in 5HT synthesis and their receptors varied markedly in beta-pancreatic cells during pregnancy, in parallel with an increase in their insulin secretion potential (probably through the action of Htr3a) and an increase in beta-cell mass (through the action of Htr2b and Htr1d). Serotonin 38-41 5-hydroxytryptamine receptor 1D Homo sapiens 303-308 24788088-9 2014 We thus show a novel role for serotonin in controlling function of the cerebellum via 5-HT2A receptors expressed by cerebellar granule cells. Serotonin 30-39 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 86-92 24882158-2 2014 We examined the effect of estradiol, progesterone and DHEAS on serotonin neurotransmission in 16 premenopausal and 28 postmenopausal women, differentiating by reproductive status. Serotonin 63-72 sulfotransferase family 2A member 1 Homo sapiens 54-59 25065370-12 2014 Finally, we showed that CCL2 hyperpolarized serotonergic raphe neurons in mouse midbrain slices, thus probably reducing the serotonin tone in projection areas. Serotonin 124-133 chemokine (C-C motif) ligand 2 Mus musculus 24-28 24942188-1 2014 BACKGROUND: Chronic alcohol use depletes brain serotonin (5-hydroxytryptamine [5-HT]), yet we previously found more tryptophan hydroxylase 2 (TPH2), the rate-limiting biosynthetic enzyme for 5-HT, in the dorsal raphe nucleus (DRN) of alcoholics. Serotonin 58-77 tryptophan hydroxylase 2 Homo sapiens 142-146 24607934-2 2014 BDNF affects serotonin signaling, increases serotonin levels in brain tissue and prevents degeneration of serotonin neurons. Serotonin 13-22 brain derived neurotrophic factor Homo sapiens 0-4 24607934-2 2014 BDNF affects serotonin signaling, increases serotonin levels in brain tissue and prevents degeneration of serotonin neurons. Serotonin 44-53 brain derived neurotrophic factor Homo sapiens 0-4 24607934-2 2014 BDNF affects serotonin signaling, increases serotonin levels in brain tissue and prevents degeneration of serotonin neurons. Serotonin 44-53 brain derived neurotrophic factor Homo sapiens 0-4 24488404-4 2014 RESULTS: Hallucinogens and mefloquine bound stereoselectively and with relatively high affinity (K i = 0.71-341 nM) to serotonin (5-HT) 2A but not 5-HT1A or 5-HT2C receptors. Serotonin 119-128 5-hydroxytryptamine receptor 2C Homo sapiens 157-163 24074042-2 2014 Genetic variation in the serotonin system might modulate bone metabolism changes during SRI treatment. Serotonin 25-34 sorcin Homo sapiens 88-91 24831114-2 2014 Previous work on the interaction between these two systems suggests that serotonin modulates photic input to the central circadian clock (the suprachiasmatic nuclei; SCN) from the retina and serves as a signal for locomotor activity, novelty, and arousal to shift the SCN clock, but effects of disruption of serotonergic signaling from the raphe nuclei on circadian behavior and on SCN function are not fully characterized. Serotonin 73-82 sorcin Homo sapiens 166-169 24831114-2 2014 Previous work on the interaction between these two systems suggests that serotonin modulates photic input to the central circadian clock (the suprachiasmatic nuclei; SCN) from the retina and serves as a signal for locomotor activity, novelty, and arousal to shift the SCN clock, but effects of disruption of serotonergic signaling from the raphe nuclei on circadian behavior and on SCN function are not fully characterized. Serotonin 73-82 sorcin Homo sapiens 268-271 24831114-2 2014 Previous work on the interaction between these two systems suggests that serotonin modulates photic input to the central circadian clock (the suprachiasmatic nuclei; SCN) from the retina and serves as a signal for locomotor activity, novelty, and arousal to shift the SCN clock, but effects of disruption of serotonergic signaling from the raphe nuclei on circadian behavior and on SCN function are not fully characterized. Serotonin 73-82 sorcin Homo sapiens 268-271 24748481-2 2014 To explore this possibility, we assessed the treatment effects of desipramine and citalopram, which inhibit the reuptake of norepinephrine and serotonin into the presynaptic terminals, respectively, on changes in levels of CART-IR before and after the test swim in mouse brain. Serotonin 143-152 CART prepropeptide Mus musculus 223-227 24706871-1 2014 Galanin is a stress-inducible neuropeptide and cotransmitter in serotonin and norepinephrine neurons with a possible role in stress-related disorders. Serotonin 64-73 galanin and GMAP prepropeptide Homo sapiens 0-7 24562856-0 2014 Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists. Serotonin 89-98 5-hydroxytryptamine receptor 2C Homo sapiens 31-37 23982114-8 2014 ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam. Serotonin 150-159 solute carrier family 22 member 3 Homo sapiens 18-22 23982114-8 2014 ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam. Serotonin 150-159 solute carrier family 22 member 3 Homo sapiens 39-44 23982114-9 2014 The half maximal inhibitory concentrations of mOCT3 and hOCT3 for TPA(+), serotonin, diazepam, and ketamine are significantly different. Serotonin 74-83 solute carrier family 22 member 3 Homo sapiens 56-61 24345477-5 2014 Based on the presence of AVP fibers in the DR, we hypothesized that AVP would alter the physiology of serotonin neurons via AVP 1A receptor (V1AR) activation. Serotonin 102-111 arginine vasopressin receptor 1A Mus musculus 120-139 24345477-5 2014 Based on the presence of AVP fibers in the DR, we hypothesized that AVP would alter the physiology of serotonin neurons via AVP 1A receptor (V1AR) activation. Serotonin 102-111 arginine vasopressin receptor 1A Mus musculus 141-145 24345477-10 2014 This work highlights a new target (i.e., V1AR) for manipulating serotonin neuron excitability. Serotonin 64-73 arginine vasopressin receptor 1A Mus musculus 41-45 26491607-9 2014 Multivariate model analyses indicated that having TCP, low BDNF levels (<5000 pg/ml), and number of drinks per day were predictors of serotonin levels. Serotonin 137-146 brain derived neurotrophic factor Homo sapiens 59-63 24231511-9 2014 Brain Ang (1-7) administration profoundly modified responses to stress, indicated by altered levels of several stress hormones, including Ang II, glucocorticoid, norepinephrine, serotonin, and dopamine, in blood or stress-related brain regions. Serotonin 178-187 angiogenin Rattus norvegicus 6-9 24136241-6 2014 Our results indicate that the HTR2A and TPH2 genes in the serotonin pathway play important roles in susceptibility to BP-I. Serotonin 58-67 tryptophan hydroxylase 2 Homo sapiens 40-44 24466319-0 2014 The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. Serotonin 84-93 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 19-34 24466319-7 2014 In separate experiments, our studies revealed that these 5-HT2A receptor antagonists have the capacity to reduce serotonin-enhanced ADP-induced elevation in intracellular calcium levels and tyrosine phosphorylation. Serotonin 113-122 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 57-72 24416346-5 2014 Focusing on serotonergic signaling, we addressed a question: Does local mechanical loading to the skeleton elevate expression of tryptophan hydroxylase 2 (tph2) that is a rate-limiting enzyme for brain serotonin? Serotonin 202-211 tryptophan hydroxylase 2 Homo sapiens 129-153 24416346-5 2014 Focusing on serotonergic signaling, we addressed a question: Does local mechanical loading to the skeleton elevate expression of tryptophan hydroxylase 2 (tph2) that is a rate-limiting enzyme for brain serotonin? Serotonin 202-211 tryptophan hydroxylase 2 Homo sapiens 155-159 24189046-3 2014 Present in vivo experiments were performed to study the effects of exogenous melatonin chronically administered to old rats on the pineal biosynthesis of melatonin and the precursor serotonin (5-HT) mediated by tryptophan hydroxylase type 1 (TPH-1). Serotonin 182-191 tryptophan hydroxylase 1 Rattus norvegicus 211-247 24341949-3 2014 KEY FINDINGS: Our study shows that the transient fluoxetine-induced down-regulation of bdnf gene expression depends on an intact 5-hydroxytryptamine but not noradrenaline system or circulating glucocorticoids. Serotonin 129-148 brain-derived neurotrophic factor Rattus norvegicus 87-91 24341949-6 2014 CONCLUSIONS: Our study found strong support for a primary effect of 5-hydroxytryptamine but not noradrenaline or circulating glucocorticoids in the mediation of fluoxetine-induced down-regulation of bdnf expression. Serotonin 68-87 brain-derived neurotrophic factor Rattus norvegicus 199-203 24367510-7 2013 Since BDNF/serotonin and CREB signaling could orchestrate a positive feedback loop, our findings suggest that the induction of oxidative stress, reduction of BDNF and serotonin expression, and attenuation of CREB signaling induced by prenatal exposure to supra-therapeutic dose of buprenorphine provide evidence of potential mechanism for the development of depression-like neurobehavior. Serotonin 167-176 brain-derived neurotrophic factor Rattus norvegicus 6-10 22736538-1 2013 The cerebral serotonin (5-HT) system is involved in cognitive functions such as memory and learning and animal studies have repeatedly shown that stimulation of the 5-HT type 4 receptor (5-HT4 R) facilitates memory and learning and further that the 5-HT4 R modulates cellular memory processes in hippocampus. Serotonin 13-22 5-hydroxytryptamine receptor 4 Homo sapiens 187-194 22736538-1 2013 The cerebral serotonin (5-HT) system is involved in cognitive functions such as memory and learning and animal studies have repeatedly shown that stimulation of the 5-HT type 4 receptor (5-HT4 R) facilitates memory and learning and further that the 5-HT4 R modulates cellular memory processes in hippocampus. Serotonin 13-22 5-hydroxytryptamine receptor 4 Homo sapiens 249-256 24033289-1 2013 In the dorsal raphe nucleus, 17beta-estradiol (E2) increases the expression of the brain-specific, rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase-2 (Tph2). Serotonin 124-133 tryptophan hydroxylase 2 Homo sapiens 148-172 24033289-1 2013 In the dorsal raphe nucleus, 17beta-estradiol (E2) increases the expression of the brain-specific, rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase-2 (Tph2). Serotonin 124-133 tryptophan hydroxylase 2 Homo sapiens 174-178 23965265-2 2013 This study investigates whether social cognition varies with genetic variations of COMT and tryptophan hydroxylase-2 (TPH2), which modulate dopamine and serotonin neurotransmissions respectively, and thereby emotion regulation. Serotonin 153-162 tryptophan hydroxylase 2 Homo sapiens 92-116 23965265-2 2013 This study investigates whether social cognition varies with genetic variations of COMT and tryptophan hydroxylase-2 (TPH2), which modulate dopamine and serotonin neurotransmissions respectively, and thereby emotion regulation. Serotonin 153-162 tryptophan hydroxylase 2 Homo sapiens 118-122 23892054-4 2013 In the present study we have evaluated the capacity of the mixed serotonin (5-HT2A)/dopamine (DA D2) antagonist risperidone to block acquisition and reinstatement of MDMA induced-CPP. Serotonin 65-74 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 76-82 24018456-4 2013 The isoenzymes of alcohol dehydrogenase also participate in the metabolism of retinol and serotonin. Serotonin 90-99 aldo-keto reductase family 1 member A1 Homo sapiens 18-39 23558111-1 2013 AIMS: In response to acute ethanol consumption, tryptophan 2,3-dioxygenase (TDO) induces the kynurenine pathway (KP) through a glucocorticoid-mediated mechanism, which could lead to a dramatic accumulation of neurotoxic metabolites in association with serotonin depletion. Serotonin 252-261 tryptophan 2,3-dioxygenase Homo sapiens 48-74 23558111-1 2013 AIMS: In response to acute ethanol consumption, tryptophan 2,3-dioxygenase (TDO) induces the kynurenine pathway (KP) through a glucocorticoid-mediated mechanism, which could lead to a dramatic accumulation of neurotoxic metabolites in association with serotonin depletion. Serotonin 252-261 tryptophan 2,3-dioxygenase Homo sapiens 76-79 23353901-1 2013 There are seemingly conflicting data in the literature regarding the role of serotonin (5-HT) 5-HT2C receptors in the mouse head-twitch response (HTR) elicited by the hallucinogenic 5-HT2A/2B/2C receptor agonist 2,5-dimethoxy-4-iodoamphetamine (DOI). Serotonin 77-86 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 182-188 23266708-1 2013 Understanding the influences of genes involved in dopamine and serotonin metabolism, such as the aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes, is critical for understanding addictive behavior. Serotonin 63-72 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 134-158 23266708-1 2013 Understanding the influences of genes involved in dopamine and serotonin metabolism, such as the aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) genes, is critical for understanding addictive behavior. Serotonin 63-72 alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens 160-165 23201351-8 2013 However, serotonin-mediated inputs from the NDR to the LC modulate only fear-induced antinociception and not the defensive behaviours evoked by GABA(A) receptor blockade in the DMH. Serotonin 9-18 serine/threonine kinase 38 Homo sapiens 44-47 23421681-4 2013 The 6-position of serotonin and the para-hydroxyl groups of dopamine and norepinephrine were found to face Ala173 in hSERT, Gly153 in hDAT, and Gly149 in hNET. Serotonin 18-27 solute carrier family 6 member 3 Homo sapiens 134-138 23421681-7 2013 Uptake experiments support that the 5-hydroxyl group of serotonin and the meta-hydroxyl group norepinephrine and dopamine are placed in the hydrophilic pocket around Ala173, Ser438, and Thr439 in hSERT corresponding to Gly149, Ser419, Ser420 in hNET and Gly153 Ser422 and Ala423 in hDAT. Serotonin 56-65 solute carrier family 6 member 3 Homo sapiens 282-286 23407616-0 2013 Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Serotonin 89-98 OCTN3 Homo sapiens 15-43 23011268-3 2013 First, we found reduced levels of dopamine, serotonin and norepinephrine in the nucleus accumbens (NAC) of DISC1-Q31L mutants. Serotonin 44-53 disrupted in schizophrenia 1 Mus musculus 107-112 23201098-5 2013 The results show that IL15 modulates GABA and serotonin transmission. Serotonin 46-55 interleukin 15 Mus musculus 22-26 23336051-0 2013 A-FABP and oxidative stress underlie the impairment of endothelium-dependent relaxations to serotonin and the intima-medial thickening in the porcine coronary artery with regenerated endothelium. Serotonin 92-101 fatty acid-binding protein, adipocyte Sus scrofa 0-6 23336052-6 2013 Stimulation of 5-HT(4) receptors by an agonist further increased sAPPalpha secretion, and this effect was mediated by cAMP/Epac signaling. Serotonin 15-19 Rap guanine nucleotide exchange factor 3 Homo sapiens 123-127 23206697-8 2013 In all brain regions studied, Lsamp(-/-) mice displayed lower serotonin (5-HT) baseline levels, but a greater 5-HT turnover rate, and amphetamine increased the level of 5-HT and lowered 5-HT turnover to a greater extent in Lsamp(-/-) mice. Serotonin 62-71 limbic system-associated membrane protein Mus musculus 30-35 23317042-5 2013 Crop emptying is under complex neuroendocrine and neural control and may be influenced by multiple neuromessengers, such as serotonin and dromyosuppressin. Serotonin 124-133 LUC7 like 3 pre-mRNA splicing factor Homo sapiens 0-4 23428811-0 2013 Crucial interactions between selective serotonin uptake inhibitors and sigma-1 receptor in heart failure. Serotonin 39-48 sigma non-opioid intracellular receptor 1 Rattus norvegicus 71-87 22699957-5 2013 RESULTS: Spontaneous release of serotonin and BDNF was approximately 10-15% of total serotonin or BDNF content in platelets, but nearly all NGF was released within 10 min. Serotonin 32-41 brain-derived neurotrophic factor Rattus norvegicus 98-102 22699957-5 2013 RESULTS: Spontaneous release of serotonin and BDNF was approximately 10-15% of total serotonin or BDNF content in platelets, but nearly all NGF was released within 10 min. Serotonin 85-94 brain-derived neurotrophic factor Rattus norvegicus 46-50 23136413-3 2012 Here, three-photon microscopy imaging of endogenous serotonin in living rat brain slice, immunofluorescence, and immunogold electron microscopy detection of VMAT2 (vesicular monoamine transporter 2) establish the presence of vesicular serotonin within DR dendrites. Serotonin 235-244 solute carrier family 18 member A2 Rattus norvegicus 157-162 22915309-2 2012 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin with the neuron-specific TPH2 isoform present exclusively in the brain and encoded by the TPH2 gene on chromosome 12q21. Serotonin 77-86 tryptophan hydroxylase 2 Homo sapiens 112-116 22915309-2 2012 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of serotonin with the neuron-specific TPH2 isoform present exclusively in the brain and encoded by the TPH2 gene on chromosome 12q21. Serotonin 77-86 tryptophan hydroxylase 2 Homo sapiens 177-181 22692564-8 2012 Egr3(-/-) mice also exhibit a decreased head-twitch response to 5HT(2A)R agonist 1-(2,5-dimethoxy 4-iodophenyl)-2-amino propane (DOI). Serotonin 64-67 early growth response 3 Mus musculus 0-4 22525513-1 2012 Serotonin is produced by pulmonary arterial endothelial cells (PAEC) via tryptophan hydroxylase-1 (Tph1). Serotonin 0-9 tryptophan hydroxylase 1 Rattus norvegicus 73-97 22525513-1 2012 Serotonin is produced by pulmonary arterial endothelial cells (PAEC) via tryptophan hydroxylase-1 (Tph1). Serotonin 0-9 tryptophan hydroxylase 1 Rattus norvegicus 99-103 21747395-0 2012 Tryptophan hydroxylase(2) gene polymorphisms predict brain serotonin synthesis in the orbitofrontal cortex in humans. Serotonin 59-68 tryptophan hydroxylase 2 Homo sapiens 0-25 22345569-6 2012 Expression of the serotonin synthetic enzyme tryptophan hydroxylase 1 (TPH1) increased in strained mitral valves. Serotonin 18-27 tryptophan 5-hydroxylase 1 Ovis aries 45-69 22345569-6 2012 Expression of the serotonin synthetic enzyme tryptophan hydroxylase 1 (TPH1) increased in strained mitral valves. Serotonin 18-27 tryptophan 5-hydroxylase 1 Ovis aries 71-75 21924839-2 2012 We describe here a non-invasive rat model for hypercortisolism, as observed in major depression, and its effects on physiology, behavior, and the expression of tph2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-hydroxytryptamine; 5-HT) synthesis. Serotonin 245-254 tryptophan hydroxylase 2 Rattus norvegicus 160-164 21924839-2 2012 We describe here a non-invasive rat model for hypercortisolism, as observed in major depression, and its effects on physiology, behavior, and the expression of tph2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-hydroxytryptamine; 5-HT) synthesis. Serotonin 245-254 tryptophan hydroxylase 2 Rattus norvegicus 184-208 21924839-2 2012 We describe here a non-invasive rat model for hypercortisolism, as observed in major depression, and its effects on physiology, behavior, and the expression of tph2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-hydroxytryptamine; 5-HT) synthesis. Serotonin 256-275 tryptophan hydroxylase 2 Rattus norvegicus 160-164 21924839-2 2012 We describe here a non-invasive rat model for hypercortisolism, as observed in major depression, and its effects on physiology, behavior, and the expression of tph2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-hydroxytryptamine; 5-HT) synthesis. Serotonin 256-275 tryptophan hydroxylase 2 Rattus norvegicus 184-208 22541438-5 2012 We find that the Piwi/piRNA complex facilitates serotonin-dependent methylation of a conserved CpG island in the promoter of CREB2, the major inhibitory constraint of memory in Aplysia, leading to enhanced long-term synaptic facilitation. Serotonin 48-57 piwi like RNA-mediated gene silencing 1 Homo sapiens 17-21 22541438-5 2012 We find that the Piwi/piRNA complex facilitates serotonin-dependent methylation of a conserved CpG island in the promoter of CREB2, the major inhibitory constraint of memory in Aplysia, leading to enhanced long-term synaptic facilitation. Serotonin 48-57 activating transcription factor 2 Homo sapiens 125-130 22500608-6 2012 The results of in vivo animal studies show that serotonin-induced pain hypersensitivity in mice is reduced by either SAM pretreatment or by the combined administration of selective antagonists for beta(2)- and beta(3)-adrenergic receptors, which have been previously shown to mediate COMT-dependent pain signaling. Serotonin 48-57 catechol-O-methyltransferase Mus musculus 284-288 22285418-7 2012 Increased dopamine concentrations in stratum (p=0.034) and reduced serotonin turnover in olfactory bulb (p=0.002) were documented in Gria3-/Y mice. Serotonin 67-76 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 133-138 22285418-8 2012 These results support a role of GluA3 in the modulation of social behavior through brain dopamine and/or serotonin signaling and different AMPA receptor subunits affect social behavior through distinct mechanisms. Serotonin 105-114 glutamate receptor, ionotropic, AMPA3 (alpha 3) Mus musculus 32-37 23429762-1 2012 OBJECTIVE: This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) in treatment-refractory depression. Serotonin 206-215 brain derived neurotrophic factor Homo sapiens 59-92 23429762-1 2012 OBJECTIVE: This study examined the association between the brain-derived neurotrophic factor (BDNF) (Val66Met) polymorphism and the response to the addition of an atypical antipsychotic drug to a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) in treatment-refractory depression. Serotonin 206-215 brain derived neurotrophic factor Homo sapiens 94-98 22285725-2 2012 Fluoxetine, one of the selective serotonin reuptake inhibitors (SSRIs), has been reported to induce the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin. Serotonin 33-42 tryptophan hydroxylase 1 Rattus norvegicus 118-140 22285725-2 2012 Fluoxetine, one of the selective serotonin reuptake inhibitors (SSRIs), has been reported to induce the expression of tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin. Serotonin 33-42 tryptophan hydroxylase 1 Rattus norvegicus 142-145 22139606-0 2012 Intrahippocampal injection of brain-derived neurotrophic factor increases anxiety-related, but not panic-related defensive responses: involvement of serotonin. Serotonin 150-159 brain-derived neurotrophic factor Rattus norvegicus 30-63 22413019-4 2012 METHODOLOGY/PRINCIPAL FINDINGS: We showed previously that the profibrotic GPCR agonist serotonin (5-HT) induced kidney mesangial cell proliferation through ADAM17 activation and heparin-binding epidermal growth factor (HB-EGF) shedding. Serotonin 87-96 ADAM metallopeptidase domain 17 Homo sapiens 156-162 21835768-11 2011 We conclude that rOct1, or rOct1 and rOct2 limit the rate of the renal excretion of serotonin. Serotonin 84-93 solute carrier family 22 member 1 Rattus norvegicus 17-22 21835768-11 2011 We conclude that rOct1, or rOct1 and rOct2 limit the rate of the renal excretion of serotonin. Serotonin 84-93 solute carrier family 22 member 1 Rattus norvegicus 27-32 21418063-0 2011 Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants. Serotonin 0-9 tryptophan hydroxylase 2 Homo sapiens 60-84 21418063-1 2011 BACKGROUND: Allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (TPH2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. Serotonin 143-152 tryptophan hydroxylase 2 Homo sapiens 76-108 21418063-1 2011 BACKGROUND: Allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (TPH2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. Serotonin 143-152 tryptophan hydroxylase 2 Homo sapiens 110-114 22013552-11 2011 Th1 and Th2 cytokines have opposing effects on intestinal smooth muscle contraction via 5-hydroxytryptamine signaling. Serotonin 88-107 negative elongation factor complex member C/D Homo sapiens 0-3 20818612-2 2011 Serotonin (5-HT) depletion has been obtained via targeting of genes involved in 5-HT synthesis (Tph1 and Tph2), specification and determination of the 5-HT phenotype during development (GATA3, Pet1, and Lmx1b), and 5-HT storage or clearance (Vmat2 and SERT). Serotonin 0-9 tryptophan hydroxylase 2 Homo sapiens 105-109 21778461-2 2011 Melatonin is synthesized in the pineal gland and peripheral organs from serotonin by two enzymes, serotonin N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT). Serotonin 72-81 aralkylamine N-acetyltransferase Homo sapiens 98-127 21778461-2 2011 Melatonin is synthesized in the pineal gland and peripheral organs from serotonin by two enzymes, serotonin N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT). Serotonin 72-81 aralkylamine N-acetyltransferase Homo sapiens 129-134 21778461-2 2011 Melatonin is synthesized in the pineal gland and peripheral organs from serotonin by two enzymes, serotonin N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT). Serotonin 72-81 acetylserotonin O-methyltransferase Homo sapiens 140-175 21868165-0 2011 Trigeminocervical complex responses after lesioning dopaminergic A11 nucleus are modified by dopamine and serotonin mechanisms. Serotonin 106-115 selectin L Rattus norvegicus 65-68 21829912-3 2011 The gene for tryptophan hydroxylase 2, which is a rate limiting enzyme in serotonin synthesis, is considered an important candidate gene associated with psychiatric disorders. Serotonin 74-83 tryptophan hydroxylase 2 Homo sapiens 13-37 21375463-5 2011 Both TLR7 agonists were shown to reduce serotonin-induced bronchoconstriction, which is possibly exerted via the p38MAPK and NF-kappaB pathways. Serotonin 40-49 toll-like receptor 7 Cavia porcellus 5-9 21353664-1 2011 BACKGROUND: Serotonin 1B (5-HT(1B)) autoreceptors regulate release of serotonin from terminals of dorsal raphe nucleus (DRN) projections. Serotonin 70-79 5-hydroxytryptamine receptor 1B Rattus norvegicus 26-33 21726200-4 2011 The present review provides a detailed analysis of the core promoters of NHE2, NHE3, DRA and PAT-1 and outlines the transcription factors involved in their basal regulation as well as in response to both physiological (butyrate, protein kinases and probiotics) and pathophysiological (cytokines and high levels of serotonin) stimuli. Serotonin 314-323 solute carrier family 9 member A2 Homo sapiens 73-77 21726200-4 2011 The present review provides a detailed analysis of the core promoters of NHE2, NHE3, DRA and PAT-1 and outlines the transcription factors involved in their basal regulation as well as in response to both physiological (butyrate, protein kinases and probiotics) and pathophysiological (cytokines and high levels of serotonin) stimuli. Serotonin 314-323 solute carrier family 9 member A3 Homo sapiens 79-83 21377874-0 2011 Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition. Serotonin 76-85 tyrosinase Homo sapiens 89-99 21377874-1 2011 In this manuscript, we synthesized a series of phenylpropanoid amide of serotonin 1-9, analyzed their structural importance for two biologic activities (antioxidant activity and tyrosinase inhibitory activity). Serotonin 72-81 tyrosinase Homo sapiens 178-188 21450092-6 2011 Moreover, it is believed that the hereditary or acquired involvement of tryptophan hydroxylase 2 (Tph2) or 5-hydroxytryptamine transporter (5-HTT) is responsible for the reduced concentration of serotonin in the central nervous system, causing depression and affective disorders. Serotonin 195-204 tryptophan hydroxylase 2 Homo sapiens 72-96 21450092-6 2011 Moreover, it is believed that the hereditary or acquired involvement of tryptophan hydroxylase 2 (Tph2) or 5-hydroxytryptamine transporter (5-HTT) is responsible for the reduced concentration of serotonin in the central nervous system, causing depression and affective disorders. Serotonin 195-204 tryptophan hydroxylase 2 Homo sapiens 98-102 21282654-0 2011 Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway. Serotonin 0-9 vascular endothelial growth factor A Mus musculus 97-101 21105877-3 2011 Tryptophan hydroxylase (TPH) 2, the rate-limiting enzyme in the serotonin biosynthesis, is a phenotypic marker for serotonin neurons and is known to be extremely labile to oxidation. Serotonin 64-73 tryptophan hydroxylase 2 Homo sapiens 0-30 21105877-3 2011 Tryptophan hydroxylase (TPH) 2, the rate-limiting enzyme in the serotonin biosynthesis, is a phenotypic marker for serotonin neurons and is known to be extremely labile to oxidation. Serotonin 115-124 tryptophan hydroxylase 2 Homo sapiens 0-30 21105877-10 2011 The propensity of TPH2 to misfold upon oxidation of its cysteine residues is responsible for its catalytic lability and may be related to loss of serotonin neuronal function in PD and the emergence of non-motor (psychiatric) symptoms. Serotonin 146-155 tryptophan hydroxylase 2 Homo sapiens 18-22 20959529-0 2011 Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling. Serotonin 85-94 tryptophan 2,3-dioxygenase Mus musculus 14-40 20959529-1 2011 Tryptophan 2,3-dioxygenase (TDO) is expressed in endometrium and catabolizes tryptophan, a precursor in the biosynthesis of serotonin. Serotonin 124-133 tryptophan 2,3-dioxygenase Mus musculus 0-26 20959529-1 2011 Tryptophan 2,3-dioxygenase (TDO) is expressed in endometrium and catabolizes tryptophan, a precursor in the biosynthesis of serotonin. Serotonin 124-133 tryptophan 2,3-dioxygenase Mus musculus 28-31 20959529-4 2011 Here we demonstrate that Hoxa10 regulates endometrial TDO expression and improves embryo viability through increased serotonin production. Serotonin 117-126 tryptophan 2,3-dioxygenase Mus musculus 54-57 20959529-7 2011 Decreased glandular TDO in response to HOXA10 may augment serotonin production by increasing tryptophan availability. Serotonin 58-67 tryptophan 2,3-dioxygenase Mus musculus 20-23 20959529-11 2011 Blockade of serotonin receptors 1D and 7 also resulted in impaired embryo development, indicating an essential role for Hoxa10 induction of TDO and subsequent serotonin production in embryo development. Serotonin 12-21 tryptophan 2,3-dioxygenase Mus musculus 140-143 20959529-15 2011 In endometrial glands, HOXA10 decreases TDO mRNA leading to increased serotonin that in turn acts to promote normal embryo development. Serotonin 70-79 tryptophan 2,3-dioxygenase Mus musculus 40-43 22191181-9 2011 The serotonin dysfunction found in adolescent and adult suicidal behavior could be related to the low level of BDNF, which impedes the normal development of serotonin neurons during brain development. Serotonin 4-13 brain derived neurotrophic factor Homo sapiens 111-115 22191181-9 2011 The serotonin dysfunction found in adolescent and adult suicidal behavior could be related to the low level of BDNF, which impedes the normal development of serotonin neurons during brain development. Serotonin 157-166 brain derived neurotrophic factor Homo sapiens 111-115 21760962-8 2011 We also report an increased response to the 5-HT(1A) receptor agonist 8-OH-DPAT in inducing hypothermia and a decreased 5-HT(2A) receptor function in HD animals. Serotonin 44-48 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 120-137 20868730-13 2010 These results indicate that SERT inhibition can alter the regulation of TPH, the rate limiting enzyme for serotonin biosynthesis. Serotonin 106-115 tryptophan hydroxylase 1 Rattus norvegicus 72-75 20643204-1 2010 The aim of this study was to determine whether intrauterine growth restriction produces an increase of dihydropteridine reductase activity as a compensatory mechanism that maintains the necessary concentration of cofactor, tetrahydrobiopterin, during accelerated brain serotonin biosynthesis. Serotonin 269-278 quinoid dihydropteridine reductase Rattus norvegicus 103-129 20736957-1 2010 Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. Serotonin 129-138 brain derived neurotrophic factor Homo sapiens 58-91 20736957-1 2010 Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. Serotonin 129-138 brain derived neurotrophic factor Homo sapiens 93-97 20740293-3 2010 The TPH2 isoform is responsible for the cerebral serotonin biosynthesis. Serotonin 49-58 tryptophan hydroxylase 2 Homo sapiens 4-8 20671305-3 2010 Serotonin (5-hydroxytryptamine; 5-HT) induces fibroblast proliferation via the 5-HTR(2A) and 5-HTR(2B) receptors, but its pathophysiological role in IPF remains unclear. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 95-101 20671305-3 2010 Serotonin (5-hydroxytryptamine; 5-HT) induces fibroblast proliferation via the 5-HTR(2A) and 5-HTR(2B) receptors, but its pathophysiological role in IPF remains unclear. Serotonin 11-30 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 95-101 20547007-1 2010 BACKGROUND: Oxytocin (OXT) and prolactin (PRL) are neuropeptide hormones that interact with the serotonin system and are involved in the stress response and social affiliation. Serotonin 96-105 oxytocin/neurophysin I prepropeptide Homo sapiens 12-20 20547007-1 2010 BACKGROUND: Oxytocin (OXT) and prolactin (PRL) are neuropeptide hormones that interact with the serotonin system and are involved in the stress response and social affiliation. Serotonin 96-105 oxytocin/neurophysin I prepropeptide Homo sapiens 22-25 21053743-7 2010 Heat shock protein 47, prolyl-4-hydroxylase, matrix metalloproteinase 9 (MMP9) and MMP13 tended to be down-regulated with 5HT or NF exposure, although some samples treated with the antagonist displayed normal levels of these mediators. Serotonin 122-125 matrix metallopeptidase 9 Homo sapiens 45-71 21053743-7 2010 Heat shock protein 47, prolyl-4-hydroxylase, matrix metalloproteinase 9 (MMP9) and MMP13 tended to be down-regulated with 5HT or NF exposure, although some samples treated with the antagonist displayed normal levels of these mediators. Serotonin 122-125 matrix metallopeptidase 9 Homo sapiens 73-77 20597489-2 2010 In vitro competition binding assays demonstrated that compounds 9-12 have a high affinity for the DAT and are selective for the DAT compared to the serotonin and norepinephrine transporters. Serotonin 148-157 solute carrier family 6 member 3 Macaca mulatta 98-101 20807074-3 2010 These cases are described and discussed in relation to the use of CYP2D6 and CYP2C19 pharmacogenetic testing in patients treated with serotonin-selective reuptake inhibitors. Serotonin 134-143 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 77-84 20577266-4 2010 This article describes the discovery and development of agomelatine, which possesses both melatonergic agonist and complementary 5-hydroxytryptamine 2C (5-HT2C) antagonist properties. Serotonin 129-148 5-hydroxytryptamine receptor 2C Homo sapiens 153-159 20642018-6 2004 In the human brain, MAO-B predominates and is present in both glial cells and neurons (6), most abundantly in serotonin and histamine neurons (7). Serotonin 110-119 monoamine oxidase B Homo sapiens 20-25 20213726-1 2010 The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. Serotonin 97-106 tryptophan hydroxylase 2 Homo sapiens 45-49 20739786-3 2010 It is also well known that dopamine and serotonin transporters (DAT and SERT) are monoamine neurotransmitter transporters, which participate in the metabolism of DA and 5-HT, respectively. Serotonin 40-49 solute carrier family 6 member 3 Homo sapiens 64-67 20739786-3 2010 It is also well known that dopamine and serotonin transporters (DAT and SERT) are monoamine neurotransmitter transporters, which participate in the metabolism of DA and 5-HT, respectively. Serotonin 169-173 solute carrier family 6 member 3 Homo sapiens 64-67 20331882-3 2010 The number of spinal c-Fos positive neurons of rats treated intrathecally with serotonin, noradrenaline or acetylcholine antagonists where evaluated to study the descending pathways activated by a surgical paw incision. Serotonin 79-88 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 21-26 19948720-9 2010 Consonant with the well established competitive inhibition of uptake by TCAs, the resulting binding site for TCAs in hSERT is fully overlapping with the serotonin binding site in hSERT and dissimilar to the low affinity noncompetitive TCA site reported in the leucine transporter (LeuT). Serotonin 153-162 Leucine transport, high Homo sapiens 260-279 19948720-9 2010 Consonant with the well established competitive inhibition of uptake by TCAs, the resulting binding site for TCAs in hSERT is fully overlapping with the serotonin binding site in hSERT and dissimilar to the low affinity noncompetitive TCA site reported in the leucine transporter (LeuT). Serotonin 153-162 Leucine transport, high Homo sapiens 281-285 20064585-2 2010 Allelic variation of TPH2 gene expression influences serotonin synthesis in the brain and therefore may modulate emotional processing. Serotonin 53-62 tryptophan hydroxylase 2 Homo sapiens 21-25 20396435-0 2010 Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population. Serotonin 20-29 tryptophan hydroxylase 2 Homo sapiens 68-72 20007701-8 2010 The work described here shows that in the case of rVMAT2, loss of traits acquired in evolution of function (such as serotonin transport and TBZ binding) bring about an improvement in older functions such as resistance to toxic compounds. Serotonin 116-125 solute carrier family 18 member A2 Rattus norvegicus 50-56 19782136-6 2010 Vasomotor responses were not significantly changed by 6h treatment with Abeta peptides whereas 24h treatment with either Abeta((25-35)) or Abeta((1-40)) increased vasoconstriction to 5-hydroxytryptamine (5-HT) and reduced endothelium-dependent vasodilatation to acetylcholine (ACh). Serotonin 183-202 amyloid beta precursor protein Rattus norvegicus 121-126 19782136-6 2010 Vasomotor responses were not significantly changed by 6h treatment with Abeta peptides whereas 24h treatment with either Abeta((25-35)) or Abeta((1-40)) increased vasoconstriction to 5-hydroxytryptamine (5-HT) and reduced endothelium-dependent vasodilatation to acetylcholine (ACh). Serotonin 183-202 amyloid beta precursor protein Rattus norvegicus 121-126 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Serotonin 196-205 galanin and GMAP prepropeptide Homo sapiens 17-20 21299064-5 2010 These effects of GAL in promoting overconsumption may involve various neurotransmitters, with GAL facilitating intake by stimulating norepinephrine and dopamine and reducing satiety by decreasing serotonin and acetylcholine. Serotonin 196-205 galanin and GMAP prepropeptide Homo sapiens 94-97 19827303-1 2009 Through the CB1 receptor cannabinoids modulate serotonin (5-hydroxytryptamine, 5-HT) release in the central nervous system which is connected with some of their pharmacological effects, especially antidepressant activity. Serotonin 47-56 cannabinoid receptor 1 Rattus norvegicus 12-15 19827303-1 2009 Through the CB1 receptor cannabinoids modulate serotonin (5-hydroxytryptamine, 5-HT) release in the central nervous system which is connected with some of their pharmacological effects, especially antidepressant activity. Serotonin 58-77 cannabinoid receptor 1 Rattus norvegicus 12-15 19827303-1 2009 Through the CB1 receptor cannabinoids modulate serotonin (5-hydroxytryptamine, 5-HT) release in the central nervous system which is connected with some of their pharmacological effects, especially antidepressant activity. Serotonin 79-83 cannabinoid receptor 1 Rattus norvegicus 12-15 19690620-1 2009 BACKGROUND: Candidate genes of psychological importance include 5HT2A, 5HT2C, and COMT, implicated in the serotonin, noradrenaline and dopamine pathways, which also may be involved in regulation of energy balance. Serotonin 106-115 5-hydroxytryptamine receptor 2C Homo sapiens 71-76 19692608-8 2009 These results demonstrate that ventilatory output in the neonatal period is critically dependent on serotonin neurons, which provide excitatory drive to the respiratory network via 5-HT(2A) and NK-1 receptor activation. Serotonin 100-109 tachykinin receptor 1 Mus musculus 194-207 19360904-4 2009 In addition, HDAC inhibitors enhanced serotonin-stimulated BDNF gene expression, the enhancement of which could be abolished by the inhibition of 5alpha-reduced neurosteroid production in the glioma cells. Serotonin 38-47 brain-derived neurotrophic factor Rattus norvegicus 59-63 19360904-5 2009 These results suggest that HDAC inhibitors may be able to promote the differentiation of rat C6 glioma cells through the production of 5alpha-reduced neurosteroids, resulting in the enhancement of serotonin-stimulated BDNF gene expression as a consequence of promoting their differentiation, indicating the possibility that differentiated glial cells may be implicated in preserving the integrity of neural networks as well as improving the function of neuronal cells in the brain. Serotonin 197-206 brain-derived neurotrophic factor Rattus norvegicus 218-222 19447297-5 2009 This rebound response is absent or diminished in mutant strains that lack tryptophan hydroxylase (TPH-1) or the serotonin receptors SER-7 and SER-1, and is blocked by serotonin antagonists, which implicates serotonergic mechanisms in this adaptive response. Serotonin 112-121 G_PROTEIN_RECEP_F1_2 domain-containing protein Caenorhabditis elegans 132-137 19553450-5 2009 We hypothesized that since these animals exhibit deficits in other monoamine systems (norepinephrine and serotonin), which are known to regulate some of these behaviors, the VMAT2-deficient mice may display some of the nonmotor symptoms associated with PD. Serotonin 105-114 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 174-179 19352219-2 2009 We investigated whether variants within the tryptophan hydroxylase-2 (TPH2) gene, which is required for the synthesis of serotonin (5-HT), are associated with susceptibility to developing BPAD. Serotonin 121-130 tryptophan hydroxylase 2 Homo sapiens 44-68 19352219-2 2009 We investigated whether variants within the tryptophan hydroxylase-2 (TPH2) gene, which is required for the synthesis of serotonin (5-HT), are associated with susceptibility to developing BPAD. Serotonin 121-130 tryptophan hydroxylase 2 Homo sapiens 70-74 19479059-1 2009 BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT) was named for its source (sero-) and ability to modify smooth muscle tone (tonin). Serotonin 23-42 kallikrein 1-related peptidase C2 Rattus norvegicus 16-21 19303862-0 2009 Transcriptional regulation of the human Na+/H+ exchanger NHE3 by serotonin in intestinal epithelial cells. Serotonin 65-74 solute carrier family 9 member A3 Homo sapiens 57-61 19303862-1 2009 Serotonin (5-HT) decreases NHE2 and NHE3 activities under acute conditions in human intestinal epithelial cells. Serotonin 0-9 solute carrier family 9 member A2 Homo sapiens 27-31 19303862-1 2009 Serotonin (5-HT) decreases NHE2 and NHE3 activities under acute conditions in human intestinal epithelial cells. Serotonin 0-9 solute carrier family 9 member A3 Homo sapiens 36-40 19212426-2 2009 We explored the sequences upstream of the tryptophan hydroxylase-2 (TPH-2) gene, the key enzyme in neuronal 5HT synthesis and generated lentiviral vectors, which were then tested in vivo using microinjections into the rat raphe. Serotonin 108-111 tryptophan hydroxylase 2 Rattus norvegicus 42-66 19212426-2 2009 We explored the sequences upstream of the tryptophan hydroxylase-2 (TPH-2) gene, the key enzyme in neuronal 5HT synthesis and generated lentiviral vectors, which were then tested in vivo using microinjections into the rat raphe. Serotonin 108-111 tryptophan hydroxylase 2 Rattus norvegicus 68-73 19319927-1 2009 Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. Serotonin 68-77 tryptophan hydroxylase 2 Homo sapiens 0-24 19319927-1 2009 Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. Serotonin 68-77 tryptophan hydroxylase 2 Homo sapiens 26-30 18786279-9 2009 Compensatory adaptations for the functional serotonergic impairment were evidenced, such as an enhanced release of serotonin in response to a meal allied to up-regulated hypothalamic 5-HT1B and transporter expression. Serotonin 115-124 5-hydroxytryptamine receptor 1B Rattus norvegicus 183-189 19403919-0 2009 Design, synthesis, and pharmacology of fluorescently labeled analogs of serotonin: application to screening of the 5-HT2C receptor. Serotonin 72-81 5-hydroxytryptamine receptor 2C Homo sapiens 115-121 19403919-1 2009 Novel fluorescent derivatives of serotonin have been synthesized and used as tracers for the development of a 5-HT2C fluorescence polarization assay. Serotonin 33-42 5-hydroxytryptamine receptor 2C Homo sapiens 110-116 19403919-2 2009 Serotonin analogs that feature a fluorescent probe attached through an ether linkage at the tryptamine 5-position have high affinity for the 5-HT2C receptor, and affinity is dependent on both linker length and pendent dye. Serotonin 0-9 5-hydroxytryptamine receptor 2C Homo sapiens 141-147 19374836-7 2009 Third, in an in vivo microdialysis study, TRK-820 dose-dependently attenuated the biochemical changes of both dopamine and serotonin in the prefrontal cortex of rats treated with phencyclidine without affecting their basal levels in normal rats. Serotonin 123-132 neurotrophic receptor tyrosine kinase 1 Rattus norvegicus 42-45 19073285-6 2009 Sex hormone levels were measured in female rats and correlated with TPH immunoreactivity, as hypoglossal 5HT levels vary with the estrous cycle. Serotonin 105-108 tryptophan hydroxylase 1 Rattus norvegicus 68-71 19253017-4 2009 Synaptophysin was expressed in the taste receptor cells expressing phospholipase C-beta2, as well as in the presynaptic cells harboring synaptic structures with taste nerves and containing serotonin. Serotonin 189-198 synaptophysin Homo sapiens 0-13 18823877-3 2009 Here, we investigated whether brain FoxO1 and FoxO3a can be regulated by serotonin and antidepressant treatment and whether their genetic deletion affects behaviors. Serotonin 73-82 forkhead box O3 Mus musculus 46-52 19536508-8 2009 Hypoxia -induced serotonin release was inhibited in H 146 cells by siRNA to NOX2, while siRNA to NOX4 had only a partial effect, implicating NOX 2 as the predominant NEB cell O(2) sensor. Serotonin 17-26 cytochrome b-245 beta chain Homo sapiens 76-80 19005016-6 2009 These results indicate that serotonin signaling via serotonin 2CR is necessary for the full satiating effects of CCK and GLP-1. Serotonin 28-37 cholecystokinin Mus musculus 113-116 18711746-2 2009 Our previous studies have shown that serotonin (5-HT) altered under diabetic condition was accompanied by alterations of protein kinase C-alpha (PKC-alpha) and CaMKII, and those alterations were reversed after insulin administration. Serotonin 37-46 protein kinase C, alpha Rattus norvegicus 145-154 19022290-1 2009 Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these amines in the central nervous system by their high-affinity uptake. Serotonin 32-41 solute carrier family 6 member 3 Homo sapiens 86-89 18952677-7 2008 Furthermore, chronic administration of low doses of the 5-HT(1) agonists in combination was able to prevent development of dyskinesia, and reduce the up-regulation of FosB after daily treatment with l-DOPA in the rat 6-OHDA model. Serotonin 56-60 FosB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 167-171 18718470-4 2008 Pharmacological manipulation of serotonin levels regulates synaptophysin and PSA-NCAM expression in the adult mPFC. Serotonin 32-41 synaptophysin Rattus norvegicus 59-72 18592413-6 2008 In rat hippocampal neurons, prolonged (72-hour) treatment with selective serotonin reuptake inhibitors paroxetine and citalopram significantly up-regulated BDNF and PACAP expression and down-regulated PACAP receptor (PAC1 and VPAC2) expression; the tricyclic antidepressant imipramine had an opposite effect. Serotonin 73-82 brain-derived neurotrophic factor Rattus norvegicus 156-160 18794646-3 2008 In this study, the effect of genetic variants of the ADRA2A gene on the response to selective serotonin reuptake inhibitors (SSRIs)/serotonin norepinephrine reuptake inhibitors (SNRIs) was examined in depressed patients. Serotonin 94-103 adrenoceptor alpha 2A Homo sapiens 53-59 19066419-1 2008 The role of 5-hydroxytryptamine (serotonin; 5-HT)2C receptors in anxiety and the anxiolytic effects of drugs is well documented. Serotonin 12-31 5-hydroxytryptamine receptor 2C Rattus norvegicus 44-51 18598674-11 2008 ERbeta and PR were detected in CART neurons and CART fibers appeared to innervate TPH-positive serotonin neurons in the dorsal raphe. Serotonin 95-104 tryptophan hydroxylase 1 Macaca mulatta 82-85 18499489-1 2008 We used the MembStruk computational procedure to predict the three-dimensional (3D) structure for the serotonin 5-HT(2C) G-protein-coupled receptor (GPCR). Serotonin 102-111 5-hydroxytryptamine receptor 2C Homo sapiens 112-119 18499489-4 2008 We performed molecular dynamics (MD) on serotonin bound to 5-HT(2C) and we find the protein and binding site to be stable after 5ns. Serotonin 40-49 5-hydroxytryptamine receptor 2C Homo sapiens 59-66 18499489-7 2008 We also compare a preliminary prediction for 5-HT(2B) with our prediction for 5-HT(2C) and find a difference in TM5 that contributes to different serotonin binding modes in 5-HT(2B) and 5-HT(2C). Serotonin 146-155 5-hydroxytryptamine receptor 2C Homo sapiens 78-85 18499489-7 2008 We also compare a preliminary prediction for 5-HT(2B) with our prediction for 5-HT(2C) and find a difference in TM5 that contributes to different serotonin binding modes in 5-HT(2B) and 5-HT(2C). Serotonin 146-155 5-hydroxytryptamine receptor 2C Homo sapiens 186-193 18180764-2 2008 Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. Serotonin 81-90 tryptophan hydroxylase 2 Homo sapiens 0-24 18180764-2 2008 Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. Serotonin 81-90 tryptophan hydroxylase 2 Homo sapiens 26-30 18180764-2 2008 Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. Serotonin 161-170 tryptophan hydroxylase 2 Homo sapiens 0-24 18180764-2 2008 Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. Serotonin 161-170 tryptophan hydroxylase 2 Homo sapiens 26-30 18502539-0 2008 Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Serotonin 69-78 glucagon Rattus norvegicus 0-23 18502539-0 2008 Glucagon-like peptide 1 (7-36) amide (GLP-1) and exendin-4 stimulate serotonin release in rat hypothalamus. Serotonin 69-78 glucagon Rattus norvegicus 38-43 18502539-3 2008 In the present paper we have evaluated the effects of GLP-1 and exendin-4 on dopamine, norepinephrine, and serotonin release from rat hypothalamic synaptosomes, in vitro. Serotonin 107-116 glucagon Rattus norvegicus 54-59 18502539-5 2008 We can conclude that the central anorectic effects of GLP-1 agonists could be partially mediated by increased serotonin release in the hypothalamus, leaving the catecholamine release unaffected. Serotonin 110-119 glucagon Rattus norvegicus 54-59 18474368-0 2008 Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. Serotonin 57-66 brain-derived neurotrophic factor Rattus norvegicus 13-46 18474368-0 2008 Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. Serotonin 57-66 brain-derived neurotrophic factor Rattus norvegicus 48-52 18496129-10 2008 The therapeutically relevant variant rs10897346 is completely linked with the functional Pro312Pro polymorphism, which is known to affect TPH2 expression and may influence serotonin synthesis in the brain. Serotonin 172-181 tryptophan hydroxylase 2 Homo sapiens 138-142 18339632-10 2008 Because this domain is unique to TPH2, these data provide evidence for selective regulation of brain serotonin synthesis. Serotonin 101-110 tryptophan hydroxylase 2 Homo sapiens 33-37 17949690-9 2008 CONCLUSIONS: These findings demonstrate that serotonin plays a similar role in modifying the long-term behavioral effects of rearing environment in diverse mammalian species and identifies BDNF as a molecular substrate of this risk factor. Serotonin 45-54 brain derived neurotrophic factor Homo sapiens 189-193 18547240-6 2008 This, together with our previous findings, suggests that corticoid rhythms permit both serotonin and NO access to BDNF, and the latter to regulate progenitor cell activity. Serotonin 87-96 brain-derived neurotrophic factor Rattus norvegicus 114-118 18310473-5 2008 We confirmed that TAAR1 was activated by dopamine, norepinephrine, and serotonin and demonstrated that TAAR1 signaling was attenuated by monoamine autoreceptors at exposure to dopamine, norepinephrine, and serotonin. Serotonin 71-80 trace amine associated receptor 1 Homo sapiens 18-23 18180753-8 2008 Higher TPH2 expression in depressed suicides may explain more TPH2 protein and reflect a homeostatic response to deficient serotonin levels in the brains of depressed suicides. Serotonin 123-132 tryptophan hydroxylase 2 Homo sapiens 7-11 18287335-7 2008 The reconstituted purified rVMAT2 has wild-type affinity for serotonin, and its turnover rate is approximately 0.4 substrate molecule/s. Serotonin 61-70 solute carrier family 18 member A2 Rattus norvegicus 27-33 17692928-2 2008 Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), and might be related to the pathogenesis of MD. Serotonin 80-89 tryptophan hydroxylase 2 Homo sapiens 0-23 18156604-6 2008 The PKD2L1-positive cells are immunoreactive for neural cell adhesion molecule, serotonin, PGP-9.5 (ubiquitin carboxy-terminal transferase), and chromogranin A, all of which are present in Type III taste cells. Serotonin 80-89 polycystic kidney disease 2-like 1 Mus musculus 4-10 18219447-0 2008 Progesterone pretreatment enhances serotonin-stimulated BDNF gene expression in rat c6 glioma cells through production of 5alpha-reduced neurosteroids. Serotonin 35-44 brain-derived neurotrophic factor Rattus norvegicus 56-60 18219447-3 2008 On the other hand, the stimulation of the glioma cells with serotonin has been reported to enhance brain-derived neurotrophic factor (BDNF) gene expression, which may be closely related to the beneficial effects of antidepressant drugs. Serotonin 60-69 brain-derived neurotrophic factor Rattus norvegicus 99-132 18219447-3 2008 On the other hand, the stimulation of the glioma cells with serotonin has been reported to enhance brain-derived neurotrophic factor (BDNF) gene expression, which may be closely related to the beneficial effects of antidepressant drugs. Serotonin 60-69 brain-derived neurotrophic factor Rattus norvegicus 134-138 18177844-1 2008 Serotonin (5-HT) system has a significant role in anxiety- and depression-related states and may be influenced by brain-derived neurotrophic factor (BDNF). Serotonin 0-9 brain-derived neurotrophic factor Rattus norvegicus 114-147 18177844-1 2008 Serotonin (5-HT) system has a significant role in anxiety- and depression-related states and may be influenced by brain-derived neurotrophic factor (BDNF). Serotonin 0-9 brain-derived neurotrophic factor Rattus norvegicus 149-153 18256476-5 2008 These recombinant dmST1, 3, and 4 products showed high sulfating activity toward phenolic compounds such as vanillin and 4-nitrophenol, but showed no activity toward typical endogenous substrates such as tyramine and serotonin. Serotonin 217-226 Sulfotransferase 1 Drosophila melanogaster 18-23 17566715-9 2008 By using microdialysis with high performance liquid chromatography-electrochemical detection, the functional release of serotonin in the process of serotoninergic differentiation of IM-treated NSCs was concomitantly increasing and mediated by the activation of the BDNF/MAPK/ERK pathway/Bcl-2 cascades. Serotonin 120-129 brain-derived neurotrophic factor Rattus norvegicus 265-269 18938672-0 2008 A synergic effect between lowered serotonin and novel situations on impulsivity measured by CPT. Serotonin 34-43 choline phosphotransferase 1 Homo sapiens 92-95 18045717-3 2008 Our results might be evidence of a functional adaptation mechanism in which increased expression of 5HT2C mRNA isoforms that encode receptors more sensitive to serotonin works to activate brainstem-spinal descending 5HT systems to, in effect, suppress transmission of nociceptive signals from primary afferent neurons to the spinal dorsal horn. Serotonin 160-169 5-hydroxytryptamine receptor 2C Homo sapiens 100-105 18240382-0 2008 1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. Serotonin 46-55 sarcosine dehydrogenase Homo sapiens 33-36 18569588-2 2008 Arylalkylamine N-acetyltransferase (AANAT) is known to catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis. Serotonin 83-92 aralkylamine N-acetyltransferase Homo sapiens 0-34 18569588-2 2008 Arylalkylamine N-acetyltransferase (AANAT) is known to catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis. Serotonin 83-92 aralkylamine N-acetyltransferase Homo sapiens 36-41 18077582-11 2007 These observations are the first to suggest that antiserum to serotonin when administered into the CSF during the early phase of CHI are capable of inducing neuroprotection. Serotonin 62-71 colony stimulating factor 2 Rattus norvegicus 99-102 18091588-0 2007 Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. Serotonin 17-26 ras homolog family member A Rattus norvegicus 57-61 17868301-1 2007 Alterations in brain serotonin levels are implicated in major depression and are regulated by tryptophan hydroxylase-2 (TPH2). Serotonin 21-30 tryptophan hydroxylase 2 Rattus norvegicus 94-118 17868301-1 2007 Alterations in brain serotonin levels are implicated in major depression and are regulated by tryptophan hydroxylase-2 (TPH2). Serotonin 21-30 tryptophan hydroxylase 2 Rattus norvegicus 120-124 17766642-3 2007 Using vesicles prepared from rat VMAT2 containing recombinant baculovirus-infected Sf9 cells, we show the inhibition of [3H]5-hydroxytryptamine (5-HT) uptake and [3H]dihydrotetrabenazine (TBZOH) binding by aminoflisopolol and iodoaminoflisopolol. Serotonin 145-149 solute carrier family 18 member A2 Rattus norvegicus 33-38 17689529-0 2007 Lu 35-138 ((+)-(S)-3-{1-[2-(1-acetyl-2,3-dihydro-1H-indol-3-yl)ethyl]-3,6-dihydro-2H-pyridin-4-yl}-6-chloro-1H-indole), a dopamine D4 receptor antagonist and serotonin reuptake inhibitor: characterisation of its in vitro profile and pre-clinical antipsychotic potential. Serotonin 158-167 dopamine receptor D4 Rattus norvegicus 122-142 17940054-4 2007 The genes encoding the serotonin reuptake transporter (SERT) and the type 7 serotonin receptor (5-HT(7)) were expressed in human and mouse mammary epithelial cells, and serotonin caused a concentration-dependent increase of cAMP in MCF10A cells. Serotonin 23-32 cathelicidin antimicrobial peptide Mus musculus 224-228 17913892-4 2007 We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice. Serotonin 40-49 CART prepropeptide Mus musculus 165-169 17913892-4 2007 We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice. Serotonin 40-49 CART prepropeptide Mus musculus 171-216 17913892-4 2007 We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice. Serotonin 51-70 CART prepropeptide Mus musculus 165-169 17913892-4 2007 We show here that direct stimulation of serotonin (5-hydroxytryptamine, 5-HT) 4 receptors (5-HT(4)R) in the NAc reduces the physiological drive to eat and increases CART (cocaine- and amphetamine-regulated transcript) mRNA levels in fed and food-deprived mice. Serotonin 51-70 CART prepropeptide Mus musculus 171-216 17620344-6 2007 The coexpression of both UGT1A1 and UGT1A4 increased the V(max) values of UGT1A6-catalyzed serotonin and diclofenac O-glucuronide formation. Serotonin 91-100 UDP glucuronosyltransferase family 1 member A1 Homo sapiens 25-31 17686476-0 2007 3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1). Serotonin 3-12 forkhead box M1 Homo sapiens 80-85 17628426-0 2007 Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons. Serotonin 0-9 carbonic anhydrase 3 Cavia porcellus 107-110 17203014-0 2007 Endogenous serotonin excites striatal cholinergic interneurons via the activation of 5-HT 2C, 5-HT6, and 5-HT7 serotonin receptors: implications for extrapyramidal side effects of serotonin reuptake inhibitors. Serotonin 11-20 5-hydroxytryptamine receptor 2C Rattus norvegicus 85-92 17251907-2 2007 Recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (TPH2) is preferentially involved in the rate limiting synthesis of neuronal serotonin. Serotonin 181-190 tryptophan hydroxylase 2 Homo sapiens 105-109 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Serotonin 128-137 transient receptor potential cation channel subfamily M member 6 Homo sapiens 66-71 17575980-4 2007 Five other transporters were downregulated; aquaporin 10, SLC6A4, TRPM6, SLC23A1 and SLC30A4, which have specificity for water, serotonin (5-HT), magnesium, vitamin C and zinc, respectively. Serotonin 128-137 solute carrier family 30 member 4 Homo sapiens 85-92 17592150-6 2007 Activation of the Wnt pathway by conditionally deleting exon 3 of the beta-catenin gene at an early stage of enteroendocrine cell differentiation induced small-intestinal adenomas expressing serotonin, a feature not previously described in other tumors induced by Wnt in mice. Serotonin 191-200 catenin (cadherin associated protein), beta 1 Mus musculus 70-82 17303597-0 2007 CD4+ T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection. Serotonin 84-103 CD4 antigen Mus musculus 0-3 17559891-8 2007 Striatal serotonin (5-HT) levels were also decreased in PDE1B knockout mice, although levels of the metabolite, 5HIAA, were unchanged. Serotonin 9-18 phosphodiesterase 1B, Ca2+-calmodulin dependent Mus musculus 56-61 17176492-1 2007 Variation in the tryptophan hydroxylase-2 gene (TPH2) coding for the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain modulates responses of limbic circuits to emotional stimuli and has been linked to a spectrum of clinical populations characterized by emotional dysregulation. Serotonin 93-102 tryptophan hydroxylase 2 Homo sapiens 17-41 17176492-1 2007 Variation in the tryptophan hydroxylase-2 gene (TPH2) coding for the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain modulates responses of limbic circuits to emotional stimuli and has been linked to a spectrum of clinical populations characterized by emotional dysregulation. Serotonin 93-102 tryptophan hydroxylase 2 Homo sapiens 48-52 18364675-2 2007 These isoenzymes of ADH participate in the metabolism of many biological substances, such as retinol or serotonin. Serotonin 104-113 aldo-keto reductase family 1 member A1 Homo sapiens 20-23 17196950-8 2007 Among them, cyclophilin A, 14-3-3 protein z/delta and GRP78 are involved in neuroprotection, in serotonin biosynthesis and in axonal transport, respectively. Serotonin 96-105 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 54-59 17224717-3 2007 The current study measured SERT occupancy and modulation of DAT by the serotonin/norepinephrine reuptake inhibitor (SNRI) venlafaxine using [123I]2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane SPECT. Serotonin 71-80 solute carrier family 6 member 3 Homo sapiens 60-63 17174312-5 2007 However, serotonin stimulated phosphorylation of endogenous and recombinant Ras-GRF1, increased [Ca(2+)](i) and caused Ca(2+)- and calmodulin-dependent ERK1/2 phosphorylation. Serotonin 9-18 Ras protein specific guanine nucleotide releasing factor 1 Homo sapiens 76-84 17233773-7 2007 The increased serotonin levels induce oxytocin release via activation of 5-HT(1A) receptors, and this might compensate for the inhibitory actions of serotonin on sexual behavior. Serotonin 14-23 oxytocin/neurophysin I prepropeptide Homo sapiens 38-46 17101120-2 2006 We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) receptors as a result of increased synaptic availability of serotonin during a critical period of development. Serotonin 163-172 5-hydroxytryptamine receptor 1B Rattus norvegicus 94-101 16890216-0 2006 SER-1, a Caenorhabditis elegans 5-HT2-like receptor, and a multi-PDZ domain containing protein (MPZ-1) interact in vulval muscle to facilitate serotonin-stimulated egg-laying. Serotonin 143-152 Multiple PDZ domain protein Caenorhabditis elegans 96-101 16876769-2 2006 Because evidence suggests that BDNF is an important determinant of the function of the 5-hydroxytryptamine (5-HT) system, we also quantified tissue levels of 5-HT and its major metabolite, 5-hydroxyindoleacetic acid (5-HIAA), to investigate if changes in BDNF mRNA and protein paralleled changes in the 5-HT system. Serotonin 87-106 brain-derived neurotrophic factor Rattus norvegicus 31-35 16687477-5 2006 Pretreatment with the serotonin transporter inhibitor fluoxetine blocked both this acute effect on VMAT-2 and the decrease in serotonin content observed 7 days after METH treatment. Serotonin 22-31 solute carrier family 18 member A2 Rattus norvegicus 99-105 16641389-0 2006 Serotonin-immunoreactive CPT interneurons in Hermissenda: identification of sensory input and motor projections. Serotonin 0-9 choline phosphotransferase 1 Homo sapiens 25-28 16382023-5 2006 We show that cAMP-response element binding protein (CREB) phosphorylation and gene expression were stimulated by serotonin (5-HT) in the absence of neuronal activity. Serotonin 113-122 cAMP responsive element binding protein 1 Homo sapiens 13-50 16382023-5 2006 We show that cAMP-response element binding protein (CREB) phosphorylation and gene expression were stimulated by serotonin (5-HT) in the absence of neuronal activity. Serotonin 113-122 cAMP responsive element binding protein 1 Homo sapiens 52-56 16289360-7 2006 BDNF correlated with decreased Serotonin (5-HT) levels in serum (r>0.6 and p<0.001 at all time points). Serotonin 31-40 brain derived neurotrophic factor Homo sapiens 0-4 16515684-2 2006 The transporters for the monoamines dopamine, norepinephrine, and serotonin (DAT, NET, and SERT) are targets for several popular psychostimulant drugs of abuse. Serotonin 66-75 solute carrier family 6 member 3 Homo sapiens 77-80 16530518-4 2006 METHODS: BDNF and a specific antiserum were examined for their effects on the peristaltic reflex and release of the sensory mediators serotonin and calcitonin gene-related peptide in rat colon. Serotonin 134-143 brain-derived neurotrophic factor Rattus norvegicus 9-13 16465492-9 2006 The neocortex of rats developing in conditions of blockade of serotonin synthesis showed smaller numbers of GFAP-positive cells, particularly in the white matter, at all stages of postnatal development studied. Serotonin 62-71 glial fibrillary acidic protein Rattus norvegicus 108-112 16384907-9 2006 Furthermore, the indisputable role of tyrosine is corroborated by the THT-F145Y mutant that uses serotonin as the acyl acceptor. Serotonin 97-106 tyramine N-feruloyltransferase 4/11-like Capsicum annuum 70-73 16195233-2 2005 Previously, we demonstrated that serotonin 5-hydroxytryptamine2C (5-HT2C) receptors form homodimers (Herrick-Davis, K., Grinde, E., and Mazurkiewicz, J. Serotonin 33-42 5-hydroxytryptamine receptor 2C Homo sapiens 66-72 16438660-1 2005 The serotonin (5-hydroxytryptamine) 5-HT2 receptor subfamily consists of three members, 5-HT2A, 5-HT2B, and 5-HT2C. Serotonin 4-13 5-hydroxytryptamine receptor 2C Homo sapiens 108-114 16326837-5 2005 Our results indicate that ANP(1-28), CNP(1-22) and C-ANF inhibited cAMP synthesis stimulated by the physiological agonists histamine and 5-hydroxytryptamine or directly by forskolin. Serotonin 137-156 natriuretic peptide A Rattus norvegicus 53-56 16116490-3 2005 Here, we investigated the effect of polymorphic variants in the gene of the tryptophan hydroxylase-2 (TPH2), the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain, in children and adolescents with ADHD. Serotonin 137-146 tryptophan hydroxylase 2 Homo sapiens 76-100 16116490-3 2005 Here, we investigated the effect of polymorphic variants in the gene of the tryptophan hydroxylase-2 (TPH2), the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain, in children and adolescents with ADHD. Serotonin 137-146 tryptophan hydroxylase 2 Homo sapiens 102-106 16359723-6 2005 Furthermore, as with selective serotonin reuptake inhibitors such as fluvoxamine and paroxetine, SIV was also reduced by the serotonin and noradrenaline reuptake inhibitor milnacipran and the metabotropic glutamate receptor 5 antagonist MPEP, while desipramine was without effect. Serotonin 31-40 glutamate metabotropic receptor 5 Rattus norvegicus 192-225 16237719-9 2005 In the medial prefrontal cortex of AQP4-knockout mice, the levels of serotonin and norepinephrine were increased, but no significant change in dopamine level was found. Serotonin 69-78 aquaporin 4 Mus musculus 35-39 16081479-6 2005 CFTR was activated in myocytes maintained in medium containing either high potassium or 5-hydroxytryptamine (5-HT) and was inhibited by CFTR(inh)-172, glibenclamide and diphenylamine-2,2"-dicarboxylic acid (DPC). Serotonin 88-107 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 16081479-6 2005 CFTR was activated in myocytes maintained in medium containing either high potassium or 5-hydroxytryptamine (5-HT) and was inhibited by CFTR(inh)-172, glibenclamide and diphenylamine-2,2"-dicarboxylic acid (DPC). Serotonin 109-113 cystic fibrosis transmembrane conductance regulator Mus musculus 0-4 16203956-1 2005 CONTEXT: Tryptophan hydroxylase 2 (TPH2) encodes the rate-limiting enzyme for brain serotonin biosynthesis. Serotonin 84-93 tryptophan hydroxylase 2 Homo sapiens 9-33 16203956-1 2005 CONTEXT: Tryptophan hydroxylase 2 (TPH2) encodes the rate-limiting enzyme for brain serotonin biosynthesis. Serotonin 84-93 tryptophan hydroxylase 2 Homo sapiens 35-39 15937150-1 2005 We showed that the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) reduces brain tissue 5-HT, decreases expression of 5-HT transporter (SERT) protein, and increases expression of glial fibrillary acidic protein (GFAP). Serotonin 19-28 glial fibrillary acidic protein Rattus norvegicus 193-224 15937150-1 2005 We showed that the serotonin (5-HT) neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) reduces brain tissue 5-HT, decreases expression of 5-HT transporter (SERT) protein, and increases expression of glial fibrillary acidic protein (GFAP). Serotonin 19-28 glial fibrillary acidic protein Rattus norvegicus 226-230 15888529-0 2005 Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline. Serotonin 56-65 carbonic anhydrase 1 Homo sapiens 42-45 15888529-1 2005 Bath-applied monoamines-dopamine (DA), serotonin (5-HT), and noradrenaline (NE)-strongly suppress the perforant path (PP) input to CA1 hippocampal region with very little effect on the Schaffer collaterals (SC) input. Serotonin 39-48 carbonic anhydrase 1 Homo sapiens 131-134 15911353-0 2005 5-HT2B-mediated serotonin signaling is required for eye morphogenesis in Xenopus. Serotonin 16-25 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled L homeolog Xenopus laevis 0-6 15911353-1 2005 In this paper, we show that serotonin, via 5-HT2B receptor, is involved in Xenopus retinal histogenesis and eye morphogenesis by supporting cell proliferation and survival. Serotonin 28-37 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled L homeolog Xenopus laevis 43-49 15867649-6 2005 Polymorphism of the serotonin transporter gene (STG) leads to alterations in serotonin level and may be important in OSAS. Serotonin 20-29 chromosome 6 open reading frame 15 Homo sapiens 48-51 15614572-1 2005 RATIONALE: 5-Hydroxytryptamine, via stimulation of 5-HT 2C receptors, exerts a tonic inhibitory influence on dopaminergic neurotransmission, whereas activation of 5-HT 2A receptors enhances stimulated DAergic neurotransmission. Serotonin 11-30 5-hydroxytryptamine receptor 2C Rattus norvegicus 51-58 15717295-2 2005 Monoamine oxidases A and B (MAO-A and MAO-B) degrade biogenic amines such as dopamine and serotonin and thereby control the levels of these neurotransmitters in the central nervous system. Serotonin 90-99 monoamine oxidase B Homo sapiens 38-43 15644438-1 2005 The nocturnal increase in circulating melatonin in vertebrates is regulated by the activity of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the melatonin pathway (serotonin --> N-acetylserotonin --> melatonin). Serotonin 188-197 aralkylamine N-acetyltransferase Homo sapiens 95-129 15644438-1 2005 The nocturnal increase in circulating melatonin in vertebrates is regulated by the activity of arylalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the melatonin pathway (serotonin --> N-acetylserotonin --> melatonin). Serotonin 188-197 aralkylamine N-acetyltransferase Homo sapiens 131-136 15663479-7 2005 The differences between TPH1 and TPH2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for TPH from different sources in the past. Serotonin 88-97 tryptophan hydroxylase 2 Homo sapiens 33-37 16165284-7 2005 These results suggest that the lateral hypothalamus modifies nociception in part by activating spinally projecting serotonin neurons that act at 5-HT1A, 5-HT1B, and 5-HT3 receptors in the dorsal horn. Serotonin 115-124 5-hydroxytryptamine receptor 1B Rattus norvegicus 153-159 15325774-10 2004 Moreover, the targeted invalidation of CCK(2) receptors increased in male mice the affinity of dopamine D(2) receptors in the sub-cortical structures, whereas in female mice the increased affinity of 5-hydroxytryptamine(2) (5-HT(2)) receptors in the frontal cortex was established. Serotonin 200-219 cholecystokinin Mus musculus 39-42 15469891-0 2004 Transcription of SCO-spondin in the subcommissural organ: evidence for down-regulation mediated by serotonin. Serotonin 99-108 SCO-spondin Bos taurus 17-28 15469891-6 2004 Analyses of organ-cultured bovine SCO treated with 5HT revealed a twofold decrease of both SCO-spondin mRNA level and immunoreactive RF glycoproteins, whereas no effect on release of RF glycoproteins into the culture medium was detected. Serotonin 51-54 SCO-spondin Bos taurus 91-102 15469891-7 2004 Rats subjected to pharmacological depletion of 5HT exhibited an SCO-spondin mRNA level twofold higher than untreated rats. Serotonin 47-50 SCO-spondin Rattus norvegicus 64-75 15469891-8 2004 These results indicate that 5HT down-regulates SCO-spondin biosynthesis but apparently not its release, and suggest that 5HT may exert the effect on the SCO via the cerebrospinal fluid. Serotonin 28-31 SCO-spondin Bos taurus 47-58 15379901-5 2004 Treatment with the facilitatory neurotransmitter 5-hydroxy tryptamine (5-HT) leads to CREB repressor degradation in vivo and the degradation can be blocked by a specific proteasome inhibitor. Serotonin 49-69 cAMP responsive element binding protein 1 Homo sapiens 86-90 15379901-5 2004 Treatment with the facilitatory neurotransmitter 5-hydroxy tryptamine (5-HT) leads to CREB repressor degradation in vivo and the degradation can be blocked by a specific proteasome inhibitor. Serotonin 71-75 cAMP responsive element binding protein 1 Homo sapiens 86-90 15302781-8 2004 Serotonin also stimulated production of the 3 cytokines in wild-type fibroblasts, which was effectively reduced in 5-HT2B receptor-knockout fibroblasts. Serotonin 0-9 5-hydroxytryptamine (serotonin) receptor 2B Mus musculus 115-121 15264218-3 2004 Histamine, glutamate, carbachol, serotonin or gamma-aminobutyric acid (GABA) caused an increase of FGF-1 content. Serotonin 33-42 fibroblast growth factor 1 Rattus norvegicus 99-104 15245646-7 2004 Hydroxyindole-O-methyltransferase enhanced detoxification in the primitive photoreceptor by increasing the lipid solubility of serotonin and bis-retinyl serotonin. Serotonin 127-136 acetylserotonin O-methyltransferase Homo sapiens 0-33 15078882-5 2004 Thrombin, PAR-1-, or PAR-4-activating peptides also induced the increase of intracellular Ca(2+) concentration and the release of serotonin in a dose-dependent manner. Serotonin 130-139 F2R like thrombin or trypsin receptor 3 Homo sapiens 21-26 15050826-6 2004 The fitting of serotonin into the binding pockets of MAOs demonstrates that MAOB Tyr326 would block access of the 5-hydroxy group of serotonin into the enzyme. Serotonin 15-24 monoamine oxidase B Rattus norvegicus 76-80 15050826-6 2004 The fitting of serotonin into the binding pockets of MAOs demonstrates that MAOB Tyr326 would block access of the 5-hydroxy group of serotonin into the enzyme. Serotonin 133-142 monoamine oxidase B Rattus norvegicus 76-80 15016089-0 2004 Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex. Serotonin 71-90 prepronociceptin Mus musculus 38-49 15016089-1 2004 A synaptosomal preparation was employed to pharmacologically characterize the role of presynaptic nociceptin/orphanin FQ (N/OFQ) receptors (NOP receptors) in the regulation of 5-hydroxytryptamine release in the Swiss mouse neocortex. Serotonin 178-195 prepronociceptin Mus musculus 109-120 15016089-1 2004 A synaptosomal preparation was employed to pharmacologically characterize the role of presynaptic nociceptin/orphanin FQ (N/OFQ) receptors (NOP receptors) in the regulation of 5-hydroxytryptamine release in the Swiss mouse neocortex. Serotonin 178-195 prepronociceptin Mus musculus 122-127 15115320-0 2004 Immunization of rats with conjugates of dopamine and serotonin with bovine serum albumin prevents the development of experimental MPTP-induced depressive syndrome (electrophysiological parameters). Serotonin 53-62 albumin Rattus norvegicus 75-88 15115320-2 2004 Changes in the spectral characteristics of brain electrical activity and sleep structure during the development of experimental MPTP-induced syndrome in animals immunized with conjugates of dopamine and serotonin with bovine serum albumin and with bovine serum albumin alone were antigen-specific and reflected functional shifts in the activity of those neurotransmitter systems targeted by immunization, as well as others sensitive to changes in the body"s immunological status. Serotonin 203-212 albumin Rattus norvegicus 225-238 15123883-3 2004 A high proportion of tsA-201 cells cotransfected with the cDNAs of 5-HT(3)R and CD8 produced large amplitude responses (0.57.0 nA) to serotonin. Serotonin 134-143 CD8a molecule Homo sapiens 80-83 15554782-4 2004 One strategy for patients who have not responded to treatment with an SRI is to switch them to a serotonin-norepinephrine reuptake inhibitor, because some patients may respond better to agents that target multiple systems. Serotonin 97-106 sorcin Homo sapiens 70-73 14675154-2 2004 Because the relationship of the CACNA1A channel to serotonin signaling is unknown and potentially of therapeutic interest we have used genetic analysis of the Caenorhabditis elegans ortholog of this calcium channel, UNC-2, to help identify candidate downstream effectors of the human channel. Serotonin 51-60 calcium voltage-gated channel subunit alpha1 A Homo sapiens 32-39 14675154-6 2004 The demonstration that these evolutionarily related channels share a conserved ability to modulate tph expression through their effects on TGF-beta signaling provides the first specific example of how CACNA1A function may influence levels of the critical migraine neurotransmitter serotonin. Serotonin 281-290 calcium voltage-gated channel subunit alpha1 A Homo sapiens 201-208 14569072-0 2004 The inhibitory effect of adrenomedullin in the rat ileum: cross-talk with beta3-adrenoceptor in the serotonin-induced muscle contraction. Serotonin 100-109 adrenomedullin Rattus norvegicus 25-39 14569072-0 2004 The inhibitory effect of adrenomedullin in the rat ileum: cross-talk with beta3-adrenoceptor in the serotonin-induced muscle contraction. Serotonin 100-109 adrenoceptor beta 3 Rattus norvegicus 74-92 14699417-3 2004 We found that intermittent hypoxia elicited serotonin-dependent increases in BDNF synthesis in ventral spinal segments containing the phrenic nucleus, and the magnitude of these BDNF increases correlated with pLTF magnitude. Serotonin 44-53 brain derived neurotrophic factor Homo sapiens 77-81 14699417-3 2004 We found that intermittent hypoxia elicited serotonin-dependent increases in BDNF synthesis in ventral spinal segments containing the phrenic nucleus, and the magnitude of these BDNF increases correlated with pLTF magnitude. Serotonin 44-53 brain derived neurotrophic factor Homo sapiens 178-182 12774304-3 2003 The alpha4-subunit immunoreactivity was enriched in serotonergic (nucleus raphe magnus, pallidus, obscurus, and dorsalis) and noradrenergic (A5, locus coeruleus (LC), A7) areas associated with antinociception, where it was commonly colocalized with serotonin (5-HT) or tyrosine hydroxylase (TH) immunoreactivity. Serotonin 249-258 immunoglobulin binding protein 1 Homo sapiens 4-10 12909319-3 2003 The aim of this study was to investigate physiological role of endogenous serotonin on the regulation of atrial natriuretic peptide (ANP) secretion from the atria. Serotonin 74-83 natriuretic peptide A Rattus norvegicus 105-131 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 110-129 tryptophan 2,3-dioxygenase Homo sapiens 335-361 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 110-129 tryptophan 2,3-dioxygenase Homo sapiens 363-366 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 131-140 tryptophan 2,3-dioxygenase Homo sapiens 335-361 12871129-2 2003 In parallel it represents a source for two important biochemical pathways: the generation of neurotransmitter 5-hydroxytryptamine (serotonin) by the tetrahydrobiopterin-dependent tryptophan 5-hydroxylase, and the formation of kynurenine derivatives and nicotinamide adenine dinucleotides initiated by the enzymes tryptophan pyrrolase (tryptophan 2,3-dioxygenase, TDO) and indoleamine 2,3-dioxygenase (IDO). Serotonin 131-140 tryptophan 2,3-dioxygenase Homo sapiens 363-366 12934707-6 2003 In these brains, 5-HT2C receptor isoforms with reduced function are expressed at significantly increased levels, suggesting that the regulation of editing by synaptic serotonin is defective. Serotonin 167-176 5-hydroxytryptamine receptor 2C Homo sapiens 17-23 12795614-2 2003 We have examined the regulation of NHE-1 by two potent mitogens, serotonin (5-HT, 5-hydroxytryptamine) and angiotensin II (Ang II), in cultured VSMC derived from rat aorta. Serotonin 65-74 solute carrier family 9 member A1 Rattus norvegicus 35-40 12795614-2 2003 We have examined the regulation of NHE-1 by two potent mitogens, serotonin (5-HT, 5-hydroxytryptamine) and angiotensin II (Ang II), in cultured VSMC derived from rat aorta. Serotonin 82-101 solute carrier family 9 member A1 Rattus norvegicus 35-40 12798977-6 2003 Plasma oxytocin may function as an index of central serotonin (5-HT) function in human subjects. Serotonin 52-61 oxytocin/neurophysin I prepropeptide Homo sapiens 7-15 12615926-0 2003 Activation of GATA-4 by serotonin in pulmonary artery smooth muscle cells. Serotonin 24-33 GATA binding protein 4 Bos taurus 14-20 12604601-6 2003 Using serotonin-depleted platelets from peripheral tryptophan hydroxylase knockout (Tph1-/-) mice, we show here that the vesicular filling initiates the G protein-mediated down-regulation of VMAT2 activity. Serotonin 6-15 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 191-196 12644890-1 2003 The release of serotonin (5-HT) at serotonergic nerve terminals is regulated by 5-HT(1B) autoreceptors. Serotonin 15-24 5-hydroxytryptamine receptor 1B Rattus norvegicus 80-87 12686106-1 2003 Dopa decarboxylase (DDC) catalyzes as main reaction the stereospecific CO(2) abstraction from L-Dopa and L-5-hydroxytryptophan (5-HTP), generating the corresponding aromatic amines, dopamine and serotonin, respectively. Serotonin 195-204 dopa decarboxylase Sus scrofa 0-18 12594062-0 2003 Tumor necrosis factor-alpha-induced synthesis of interleukin-16 in airway epithelial cells: priming for serotonin stimulation. Serotonin 104-113 interleukin 16 Mus musculus 49-63 12594062-5 2003 We determined that ovalbumin (OVA)-sensitized mice have an increase in systemic tumor necrosis factor-alpha levels, and that serum or BAL fluid stimulation of bronchial epithelial cells results in production of IL-16 that is subsequently secreted only following serotonin stimulation. Serotonin 262-271 interleukin 16 Mus musculus 211-216 12647269-2 2003 Galanin (GAL) is a neuropeptide, widely distributed in the central and peripheral nervous systems, that interacts with both sympathetic and vagal systems as well as with neurotransmitters, such as serotonin. Serotonin 197-206 galanin and GMAP prepropeptide Homo sapiens 0-7 12647269-2 2003 Galanin (GAL) is a neuropeptide, widely distributed in the central and peripheral nervous systems, that interacts with both sympathetic and vagal systems as well as with neurotransmitters, such as serotonin. Serotonin 197-206 galanin and GMAP prepropeptide Homo sapiens 9-12 12623759-15 2003 Heterozygous and homozygous mutant Gunn rat livers had 40 and 13%, respectively, of the activity of the normal Wistar rat, indicating a significant contribution by a rat UGT1A isoform to serotonin glucuronidation. Serotonin 187-196 Ugt1a@ Rattus norvegicus 170-175 12576092-2 2003 In the model of in vitro gastric arteries from reserpine-treated rats, adrenomedullin pre-treatment resulted in a decrease of the vasoconstriction in response to 5-hydroxytryptamine. Serotonin 162-181 adrenomedullin Rattus norvegicus 71-85 12576092-4 2003 In the presence of the NOS inhibitor N(G)-nitro-L-arginine, the responsiveness to 5-hydroxytryptamine in gastric arteries from rats treated with reserpine + adrenomedullin was enhanced to the same level of rats treated with reserpine alone. Serotonin 82-101 adrenomedullin Rattus norvegicus 157-171 12445576-0 2002 Effect of 5-HT1A receptor-mediated serotonin augmentation on Fos immunoreactivity in rat brain. Serotonin 35-44 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 61-64 12445576-1 2002 The consequences of pharmacologically evoked augmented serotonin (5-hydroxytryptamine, 5-HT) release on neuronal activity in the brain, as reflected by the cellular expression of the immediate early gene c-fos, were studied. Serotonin 55-64 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 204-209 12445576-1 2002 The consequences of pharmacologically evoked augmented serotonin (5-hydroxytryptamine, 5-HT) release on neuronal activity in the brain, as reflected by the cellular expression of the immediate early gene c-fos, were studied. Serotonin 87-91 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 204-209 12213812-0 2002 Serotonin-induced MMP-13 production is mediated via phospholipase C, protein kinase C, and ERK1/2 in rat uterine smooth muscle cells. Serotonin 0-9 matrix metallopeptidase 13 Rattus norvegicus 18-24 12213812-1 2002 Serotonin (5-hydroxytryptamine; 5-HT), acting via the 5-HT(2A) receptor, up-regulates the transcription and production of interstitial collagenase (matrix metalloproteinase-13; MMP-13), a critical enzyme responsible for maintaining the integrity of the uterus, after parturition. Serotonin 0-9 matrix metallopeptidase 13 Rattus norvegicus 122-183 12213812-1 2002 Serotonin (5-hydroxytryptamine; 5-HT), acting via the 5-HT(2A) receptor, up-regulates the transcription and production of interstitial collagenase (matrix metalloproteinase-13; MMP-13), a critical enzyme responsible for maintaining the integrity of the uterus, after parturition. Serotonin 11-30 matrix metallopeptidase 13 Rattus norvegicus 122-183 12213812-5 2002 Protein kinase C (PKC) activators, the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol and phorbol myristate acetate (PMA), mimicked the effect of serotonin on MMP-13 protein expression; prolonged PMA treatment (which down-regulates PKC) lowered MMP-13 protein levels. Serotonin 150-159 matrix metallopeptidase 13 Rattus norvegicus 163-169 12213812-5 2002 Protein kinase C (PKC) activators, the diacylglycerol analogue 1,2-dioctanoyl-sn-glycerol and phorbol myristate acetate (PMA), mimicked the effect of serotonin on MMP-13 protein expression; prolonged PMA treatment (which down-regulates PKC) lowered MMP-13 protein levels. Serotonin 150-159 matrix metallopeptidase 13 Rattus norvegicus 249-255 12213812-6 2002 The PKC-specific inhibitors bisindolylmaleimide I, calphostin C, CGP 41251, and the PKCdelta-selective inhibitor rottlerin were able to suppress serotonin up-regulation of MMP-13. Serotonin 145-154 matrix metallopeptidase 13 Rattus norvegicus 172-178 12460606-7 2002 The area of serotonin immunoreactivity in the dorsal horn (n = 12) decreased caudal to the injury site (L1-4) and increased threefold rostral to it (T9-11). Serotonin 12-21 ribosomal protein L4 Rattus norvegicus 104-108 12231370-6 2002 RESULTS: Exposure to cyclosporine and mycophenolate mofetil was associated with a dose-dependent decrease in endothelium-dependent relaxations to serotonin (an agonist that binds to 5-HT1D receptors coupled to Gi-protein) but no impairment of relaxations to bradykinin (an agonist that binds to B2 receptors coupled to Gq-proteins). Serotonin 146-155 5-hydroxytryptamine receptor 1D Homo sapiens 182-188 12051706-0 2002 Interaction of the C-terminal region of the rat serotonin transporter with MacMARCKS modulates 5-HT uptake regulation by protein kinase C. The serotonin transporter (SERT) mediates the re-uptake of released serotonin into presynaptic nerve terminals. Serotonin 48-57 MARCKS-like 1 Rattus norvegicus 75-84 12051706-3 2002 Upon cotransfection with SERT, MacMARCKS caused a reduction in the maximal rate of [(3)H]serotonin uptake and reduced its down-regulation elicited by activation of PKC. Serotonin 89-98 MARCKS-like 1 Rattus norvegicus 31-40 12111245-1 2002 The effects of water deprivation and hydration on plasma corticosterone concentration and the activity of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, in the hypothalamus of vasopressin- (AVP-) deficient homozygous Brattleboro and normal Wistar rats were studied. Serotonin 164-173 tryptophan hydroxylase 1 Rattus norvegicus 106-128 12111245-1 2002 The effects of water deprivation and hydration on plasma corticosterone concentration and the activity of tryptophan hydroxylase (TPH), the rate-limiting enzyme in serotonin (5-HT) biosynthesis, in the hypothalamus of vasopressin- (AVP-) deficient homozygous Brattleboro and normal Wistar rats were studied. Serotonin 164-173 tryptophan hydroxylase 1 Rattus norvegicus 130-133 11929920-13 2002 Instead, the persistent effects of 5HT are mimicked by phorbol, suggesting that protein kinase C or an Aplysia homologue of unc13 may mediate these effects. Serotonin 35-38 unc-13 homolog B Homo sapiens 124-129 11896172-7 2002 A postmortem examination in GluRepsilon4 mutant mice revealed that tissue contents of norepinephrine, dopamine, serotonin, and their metabolites were reduced in the hippocampus and that dopamine, as well as serotonin, metabolism was upregulated in the frontal cortex, striatum, hippocampus, and thalamus. Serotonin 112-121 glutamate receptor, ionotropic, NMDA2D (epsilon 4) Mus musculus 28-40 11880652-5 2002 Stimulation of 5-hydroxy-tryptamine (5-HT4 and 5-HT6 receptors causes an increased phosphorylation state at Thr34-DARPP-32, the protein kinase A site, and a decreased phosphorylation state at Thr75-DARPP-32, the cyclin-dependent kinase 5 site. Serotonin 15-35 cyclin-dependent kinase 5 Mus musculus 212-237 11731550-7 2001 NK3 receptors operated synergistically with N-methyl-D-aspartate (NMDA) and 5-hydroxytryptamine (5-HT) to trigger fully alternating locomotor-like rhythms while NK3 receptor antagonism disrupted the same rhythm. Serotonin 76-95 tachykinin receptor 3 Rattus norvegicus 0-12 11783909-6 2001 Bombesin appeared to be located in enterochromaffin-like endocrine cells, which are primarily responsible for the production of serotonin. Serotonin 128-137 gastrin releasing peptide Homo sapiens 0-8 11568009-8 2001 Treatment of particles with thrombin induced serotonin release and aggregation that was blocked by CD41a antibodies. Serotonin 45-54 integrin subunit alpha 2b Homo sapiens 99-103 12030814-2 2001 In the present study we examined the influence of CART peptide fragment, CART(62-76), on the levels of catecholamines (dopamine and norepinephrine), serotonin and their metabolites in five regions of the rat brain. Serotonin 149-158 CART prepropeptide Rattus norvegicus 50-54 12030814-5 2001 In the frontal cortex, CART(62-76) increased the levels of 5-hydroxyindoleacetic acid (5-HIAA), a metabolite of serotonin (5-HT). Serotonin 112-121 CART prepropeptide Rattus norvegicus 23-27 11517274-1 2001 Thalamocortical neurons innervating the barrel cortex in neonatal rodents transiently store serotonin (5-HT) in synaptic vesicles by expressing the plasma membrane serotonin transporter (5-HTT) and the vesicular monoamine transporter (VMAT2). Serotonin 92-101 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 235-240 11478927-1 2001 5-Hydroxytryptamine (5-HT) is implicated in migraine and agonist directed against 5-HT(1B) and 5-HT(1D) receptors are commonly used as effective therapies. Serotonin 1-19 5-hydroxytryptamine receptor 1D Homo sapiens 95-102 11427721-3 2001 Formation of this AANAT/14-3-3 complex enhances melatonin production by shielding AANAT from dephosphorylation and/or proteolysis and by decreasing the K(m) for 5-hydroxytryptamine (serotonin). Serotonin 161-180 aralkylamine N-acetyltransferase Homo sapiens 18-23 11427721-3 2001 Formation of this AANAT/14-3-3 complex enhances melatonin production by shielding AANAT from dephosphorylation and/or proteolysis and by decreasing the K(m) for 5-hydroxytryptamine (serotonin). Serotonin 182-191 aralkylamine N-acetyltransferase Homo sapiens 18-23 11283010-2 2001 As the rate-limiting enzyme in serotonin biosynthesis, tryptophan hydroxylase (TPH) is a potential target for this autoregulation. Serotonin 31-40 tryptophan hydroxylase 1 Rattus norvegicus 55-77 11283010-2 2001 As the rate-limiting enzyme in serotonin biosynthesis, tryptophan hydroxylase (TPH) is a potential target for this autoregulation. Serotonin 31-40 tryptophan hydroxylase 1 Rattus norvegicus 79-82 11283010-10 2001 These data suggest a model for the autoregulation of serotonin biosynthesis by repression of MAP kinase stimulation of the TPH promoter. Serotonin 53-62 tryptophan hydroxylase 1 Rattus norvegicus 123-126 11134050-5 2001 Mutant MAO A-I335Y became like MAO B, which exhibits a higher preference for beta-phenylethylamine than for the MAO A preferred substrate serotonin (5-hydroxytryptamine), and became more sensitive to deprenyl (MAO B-specific inhibitor) than to clorgyline (MAO A-specific inhibitor). Serotonin 138-147 monoamine oxidase B Homo sapiens 31-36 11271412-1 2001 RATIONALE: The discriminative stimulus (DS) properties of the selective serotonin (5-HT) uptake inhibitor (SSRI), citalopram, are mediated by 5-HT2C receptors. Serotonin 72-81 5-hydroxytryptamine receptor 2C Rattus norvegicus 142-148 10996601-1 2000 5-hydroxytryptamine (5-HT) contracts vascular smooth muscle and pharmacological and molecular biological data suggest that these effects are mediated primarily by stimulation of 5-HT(1B) and 5-HT(2A) receptor subtypes. Serotonin 0-19 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 178-185 10936214-3 2000 When compared with MAO A, MAO A-F208I showed a sixfold decrease in the specificity constant k(cat)/K(m) for both the MAO A- and the MAO B-preferring substrates 5-hydroxytryptamine and beta-phenylethylamine, respectively. Serotonin 160-179 monoamine oxidase B Homo sapiens 132-137 10952674-0 2000 Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in human neocortex slices: involvement of 5-HT(2C) and 5-HT(1A) receptors. Serotonin 0-9 5'-nucleotidase, cytosolic II Homo sapiens 62-65 10783401-9 2000 These studies provide novel, suggestive evidence that BDNF and NT-3, possibly through their trophic effects on serotonergic neurons and/or motoneurons, may underlie serotonin-dependent plasticity in (spinal) respiratory motor control after CDR. Serotonin 165-174 brain-derived neurotrophic factor Rattus norvegicus 54-58 10970022-4 2000 These studies show that formation of defensive types of plasticity in Helix is accompanied by serotonin-induced translocation of a protein with Rf 0.58 and increases in G-protein activity, protein kinase A activity, and expression of the c-fos gene. Serotonin 94-103 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 238-243 10896039-1 2000 We investigated the late effects of serotonergic drugs on mouse forced swimming and found that serotonin 1A antagonist NAN-190 hydrobromide (NAN-190) and serotonin 2 agonist R(-)-DO1 hydrochloride (DO1) increase the typical anti-depressive behavior climbing 6 hours after the intraperitoneal injection. Serotonin 154-163 dietary obesity 1 Mus musculus 179-182 10790876-4 2000 Serotonin depletion, verified by immunohistochemistry, produced a significant decrease (42%) in the number of c-FOS positive cells in the ventrolateral portion of the SCN. Serotonin 0-9 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 110-115 10727718-2 2000 The expression of the vesicular monoamine transporter 2 (VMAT2) has been studied in the serotonergic system of the rat brain after an 18 day treatment with the serotonin selective-reuptake inhibitor paroxetine (10 mg/kg, i.p., once daily). Serotonin 160-169 solute carrier family 18 member A2 Rattus norvegicus 22-55 10727718-2 2000 The expression of the vesicular monoamine transporter 2 (VMAT2) has been studied in the serotonergic system of the rat brain after an 18 day treatment with the serotonin selective-reuptake inhibitor paroxetine (10 mg/kg, i.p., once daily). Serotonin 160-169 solute carrier family 18 member A2 Rattus norvegicus 57-62 10848798-1 2000 [14C]-Serotonin release assay (14C-SRA) from platelets is considered to be the most sensitive test for laboratory confirmation of heparin-induced thrombocytopenia (HIT). Serotonin 6-15 steroid receptor RNA activator 1 Homo sapiens 35-38 10977914-2 2000 Elevated basal tryptophan oxygenase activity in C57Bl mice is probably responsible for reduced brain content of tryptophan and serotonin associated with alcohol preference. Serotonin 127-136 tryptophan 2,3-dioxygenase Mus musculus 15-35 10686340-2 2000 Synthesis rate from serotonin to melatonin is controlled by the rapid and dramatic enzymatic increase in darkness of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, EC 2.3.1.87) and hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4). Serotonin 20-29 aralkylamine N-acetyltransferase Homo sapiens 117-146 10686340-2 2000 Synthesis rate from serotonin to melatonin is controlled by the rapid and dramatic enzymatic increase in darkness of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, EC 2.3.1.87) and hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4). Serotonin 20-29 aralkylamine N-acetyltransferase Homo sapiens 148-182 10686340-2 2000 Synthesis rate from serotonin to melatonin is controlled by the rapid and dramatic enzymatic increase in darkness of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, EC 2.3.1.87) and hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4). Serotonin 20-29 aralkylamine N-acetyltransferase Homo sapiens 184-190 10686340-2 2000 Synthesis rate from serotonin to melatonin is controlled by the rapid and dramatic enzymatic increase in darkness of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, EC 2.3.1.87) and hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4). Serotonin 20-29 acetylserotonin O-methyltransferase Homo sapiens 209-242 10686340-2 2000 Synthesis rate from serotonin to melatonin is controlled by the rapid and dramatic enzymatic increase in darkness of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, EC 2.3.1.87) and hydroxyindole-O-methyltransferase (HIOMT, EC 2.1.1.4). Serotonin 20-29 acetylserotonin O-methyltransferase Homo sapiens 244-249 10625680-8 2000 We argue that negative cross-talk between the glucocorticoid receptor and NF-kappaB may provide a basis for the molecular mechanism underlying the negative action of corticosteroids on serotonin signaling in the brain. Serotonin 185-194 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 46-69 10617146-0 2000 The effects of serotonin on glucocorticoid receptor binding in rat raphe nuclei and hippocampal cells in culture. Serotonin 15-24 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 28-51 10574568-3 1999 Previous work from this laboratory demonstrated that systemic administrations of the serotonin agonist quipazine mimic the effects of light on the circadian system of rats, i.e. they induce photic-like phase shifts of the circadian activity rhythm as well as c-Fos expression in the SCN. Serotonin 85-94 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 261-264 10535740-1 1999 In a culture system where a bifurcated Aplysia sensory neuron makes synapses with two motor neurons, repeated application of serotonin (5-HT) to one synapse produces a CREB-mediated, synapse-specific, long-term facilitation, which can be captured at the opposite synapse by a single pulse of 5-HT. Serotonin 125-134 cAMP responsive element binding protein 1 Homo sapiens 168-172 10551275-8 1999 The observed difference in functional sensitivities of 5-HT1B auto- and heteroreceptors may represent important consequences in the physiological control of the release of serotonin versus that of other neurotransmitters. Serotonin 172-181 5-hydroxytryptamine receptor 1B Rattus norvegicus 55-61 10494451-2 1999 We evaluated if a functional Cys23Ser polymorphism in the 5-HT2C receptor gene, the principal serotonin receptor in the brain, contributes to variation in serotonin, norepinephrine and dopamine activity, as indexed by their major metabolite concentrations in cerebrospinal fluid (CSF). Serotonin 94-103 5-hydroxytryptamine receptor 2C Homo sapiens 58-64 10454495-12 1999 Thus, we provide strong evidence for the 1) presence of serotonin and its direct synthesis independent of adrenergic nerves and 2) a novel excitatory effect of presynaptic 5-HT(1A) receptor activation on adrenergic nerves in a peripheral blood vessel. Serotonin 56-65 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 172-179 10454512-9 1999 A genome wide scan confirmed the presence of a QTL (peak LOD = 6.4) on chromosome 14 near the piebald (Ednrb) and 5-hydroxytryptamine(2A) (Htr2a) loci. Serotonin 114-133 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 139-144 10499366-6 1999 It is suggested that blockade of inhibitory 5-HT1A autoreceptors discloses inhibitory effects of the selective serotonin re-uptake inhibitor citalopram on male rat ejaculatory behavior mediated via stimulation of 5-HT1B receptors. Serotonin 111-120 5-hydroxytryptamine receptor 1B Rattus norvegicus 213-219 10432492-0 1999 Agonist-directed signaling of serotonin 5-HT2C receptors: differences between serotonin and lysergic acid diethylamide (LSD). Serotonin 30-39 5-hydroxytryptamine receptor 2C Homo sapiens 40-46 10455282-0 1999 Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Serotonin 70-89 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 15-21 10443019-2 1999 The synthesized compounds were able to bind on some serotonin (5-HT1A, 5-HT2A) and dopamine (D2, D3) receptors, while displaying poor or no affinity for 5-HT1B, 5-HT2C, 5-HT3, and 5-HT4 subtypes. Serotonin 52-61 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 71-77 10364442-6 1999 A possible serotonin synthesis by TpH was examined by giving drugs that increase brain serotonin synthesis, but no immunohistochemically detectable serotonin synthesis could be found in any of the TpH expressing neurons. Serotonin 87-96 tryptophan hydroxylase 1 Rattus norvegicus 34-37 10593574-3 1999 The participation of PKC in 5-hydroxytryptamine-, phenylephrine-, and endothelin-1 (ET-1)-induced contractions in aortae of SHR was equal to, or greater than that in WKY. Serotonin 28-47 protein kinase C, gamma Rattus norvegicus 21-24 10196464-0 1999 Regulation of CCK mRNA expression in the rat brain by stress and treatment with sertraline, a selective serotonin re-uptake inhibitor. Serotonin 104-113 cholecystokinin Rattus norvegicus 14-17 10092629-4 1999 Competition binding experiments revealed a guanine nucleotide-sensitive serotonin high affinity state only for the 5-HT2C-INI receptor; the loss of high affinity agonist binding to the edited receptor demonstrates that RNA editing generates unique 5-HT2CRs that couple less efficiently to G proteins. Serotonin 72-81 5-hydroxytryptamine receptor 2C Homo sapiens 115-121 10223282-11 1999 It is concluded that 5-HT1A, 5-HT2A+2C, and to a lesser extent 5-HT1B receptors, but not 5-HT3 receptors are involved in the effects of serotonin agonists on ACTH secretion. Serotonin 136-145 5-hydroxytryptamine receptor 1B Rattus norvegicus 63-69 10087024-9 1999 Furthermore, the combination of ketanserin and GR 127935 produced a significantly greater blockade of the amplified response than either antagonist alone, supporting the conclusion that both 5-HT2A and 5-HT1B receptors mediate the K+-amplified response to serotonin in the rabbit ear artery. Serotonin 256-265 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 202-208 10218785-0 1999 D-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala. Serotonin 23-32 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 42-45 10218785-0 1999 D-Fenfluramine induces serotonin-mediated Fos expression in corticotropin-releasing factor and oxytocin neurons of the hypothalamus, and serotonin-independent Fos expression in enkephalin and neurotensin neurons of the amygdala. Serotonin 137-146 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 159-162 9930739-0 1999 GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis. Serotonin 65-74 GTP cyclohydrolase I feedback regulator Rattus norvegicus 0-48 9930739-4 1999 GFRP mRNA expression was abundant in serotonin neurons of the dorsal raphe nucleus but was undetectable in dopamine neurons of the midbrain or norepinephrine neurons of the locus coeruleus. Serotonin 37-46 GTP cyclohydrolase I feedback regulator Rattus norvegicus 0-4 9930739-15 1999 Our data suggest that GTPCH activity within serotonin neurons is under a tonic inhibitory tone mediated by GFRP and that tetrahydrobiopterin levels are maintained by the balance of intracellular concentrations of tetrahydrobiopterin and L-phenylalanine. Serotonin 44-53 GTP cyclohydrolase 1 Rattus norvegicus 22-27 9930739-15 1999 Our data suggest that GTPCH activity within serotonin neurons is under a tonic inhibitory tone mediated by GFRP and that tetrahydrobiopterin levels are maintained by the balance of intracellular concentrations of tetrahydrobiopterin and L-phenylalanine. Serotonin 44-53 GTP cyclohydrolase I feedback regulator Rattus norvegicus 107-111 10379925-8 1999 In ILPA and SPA, the sequence was: KCl>histamine>PGF2alpha>serotonin. Serotonin 68-77 pulmonary surfactant-associated protein A Oryctolagus cuniculus 12-15 10210167-2 1999 Since 5-hydroxytryptamine (5-HT) release in the hippocampus is modulated by 5-HT1B auto- and alpha2-heteroreceptors, we investigated whether such lesions may alter these presynaptic mechanisms. Serotonin 27-31 5-hydroxytryptamine receptor 1B Rattus norvegicus 76-82 9930883-6 1999 Synaptophysin immunoreactivity occurred in the serotonin cells throughout the gastrointestinal tract, and in the antral gastrin and somatostatin cells. Serotonin 47-56 synaptophysin Homo sapiens 0-13 9928257-7 1998 Thus the differential expression of serotonin receptor subtypes in the CA1 region allows serotonin to modify the function of hippocampal neuronal networks in a manner that is both selective and precise. Serotonin 36-45 carbonic anhydrase 1 Homo sapiens 71-74 9924973-2 1998 RN46A cells require brain-derived neurotrophic factor (BDNF) for increased survival and serotonin (5HT) synthesis in vitro and in vivo. Serotonin 88-97 brain-derived neurotrophic factor Rattus norvegicus 20-53 9924973-2 1998 RN46A cells require brain-derived neurotrophic factor (BDNF) for increased survival and serotonin (5HT) synthesis in vitro and in vivo. Serotonin 88-97 brain-derived neurotrophic factor Rattus norvegicus 55-59 9924973-2 1998 RN46A cells require brain-derived neurotrophic factor (BDNF) for increased survival and serotonin (5HT) synthesis in vitro and in vivo. Serotonin 99-102 brain-derived neurotrophic factor Rattus norvegicus 55-59 9804794-1 1998 Serotonin N-acetyltransferase (arylalkylamine N-ace-tyltransferase (AANAT)) catalyzes the reaction of serotonin (or tryptamine) with acetyl-CoA to form N-acetylserotonin (or N-acetyltryptamine) and is responsible for the melatonin circadian rhythm in vertebrates. Serotonin 102-111 aralkylamine N-acetyltransferase Homo sapiens 0-29 9804794-1 1998 Serotonin N-acetyltransferase (arylalkylamine N-ace-tyltransferase (AANAT)) catalyzes the reaction of serotonin (or tryptamine) with acetyl-CoA to form N-acetylserotonin (or N-acetyltryptamine) and is responsible for the melatonin circadian rhythm in vertebrates. Serotonin 102-111 aralkylamine N-acetyltransferase Homo sapiens 31-66 9804794-1 1998 Serotonin N-acetyltransferase (arylalkylamine N-ace-tyltransferase (AANAT)) catalyzes the reaction of serotonin (or tryptamine) with acetyl-CoA to form N-acetylserotonin (or N-acetyltryptamine) and is responsible for the melatonin circadian rhythm in vertebrates. Serotonin 102-111 aralkylamine N-acetyltransferase Homo sapiens 68-73 9804794-3 1998 3-Indolepropylamine and 3-indolebutylamine were chemically synthesized and found to be processed by AANAT, although 20- and 60-fold less efficiently compared with the natural substrate serotonin, respectively. Serotonin 185-194 aralkylamine N-acetyltransferase Homo sapiens 100-105 9804794-4 1998 Racemic alpha-methyltryptamine and Nomega-methyltryptamine were also shown to be substrates for AANAT, again with reduced kcat and kcat/Km compared with serotonin. Serotonin 153-162 aralkylamine N-acetyltransferase Homo sapiens 96-101 9815038-6 1998 Serotonin (1-5 microM) and peptide YY (10 nM) evoked mucin discharge, whereas glucagon-like peptide-1 did not release mucin. Serotonin 0-9 solute carrier family 13 member 2 Rattus norvegicus 53-58 9768567-4 1998 In fibroblasts transfected with the 5-HT2A receptor or the 5-HT2C receptor, DMT activated the major intracellular signaling pathway (phosphoinositide hydrolysis) to an extent comparable to that produced by serotonin. Serotonin 206-215 5-hydroxytryptamine receptor 2C Homo sapiens 59-65 9765360-0 1998 Oxytocin inhibits the uptake of serotonin into uterine mast cells. Serotonin 32-41 oxytocin Mus musculus 0-8 9765360-6 1998 Oxytocin inhibited [3H]5HT uptake into uterine mast cells during estrus, but not in ovarectomized mice treated with progesterone. Serotonin 23-26 oxytocin Mus musculus 0-8 9765360-9 1998 These findings support a new potential role of oxytocin and mast cells as a local regulators of serotonin bioavailability in myometrium. Serotonin 96-105 oxytocin Mus musculus 47-55 9765360-10 1998 Because serotonin is recognized as an important endogenous uterotonic compound, this effect could be considered as an indirect action of oxytocin that may contribute to its potency as a labor inducer after genomic effects of estrogens are expressed in uterine tissue. Serotonin 8-17 oxytocin Mus musculus 137-145 9692731-2 1998 The alpha2C-adrenoceptor is the most abundant alpha2-adrenoceptor subtype in the striatum and modulates metabolism of both dopamine and serotonin. Serotonin 136-145 adrenergic receptor, alpha 2c Mus musculus 4-24 9808344-7 1998 SDZ ASM 981 inhibited exocytosis of preformed mediators (e.g. serotonin) with an IC50 of approximately 30 nM. Serotonin 62-71 H19, imprinted maternally expressed transcript (non-protein coding) Rattus norvegicus 4-7 9705293-1 1998 GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C. GTP cyclohydrolase I controls the de novo pathway for the synthesis of tetrahydrobiopterin, which is the essential cofactor for tryptophan 5-monooxygenase and thus, for serotonin production. Serotonin 293-302 GTP cyclohydrolase 1 Rattus norvegicus 0-20 9705293-1 1998 GTP cyclohydrolase I hyperphosphorylation is coupled to high affinity IgE receptor signaling and involves protein kinase C. GTP cyclohydrolase I controls the de novo pathway for the synthesis of tetrahydrobiopterin, which is the essential cofactor for tryptophan 5-monooxygenase and thus, for serotonin production. Serotonin 293-302 GTP cyclohydrolase 1 Rattus norvegicus 124-144 9749765-0 1998 Serotonin inhibits synaptic glutamate currents in rat nucleus accumbens neurons via presynaptic 5-HT1B receptors. Serotonin 0-9 5-hydroxytryptamine receptor 1B Rattus norvegicus 96-102 10375791-1 1998 AIM: To study the effects of arachidonic acid (AA)-induced endogenous serotonin (5-HT) release on platelet aggregation and ATP release by thrombin (Thr). Serotonin 70-79 prothrombin Oryctolagus cuniculus 138-146 9714293-6 1998 Thrombin, thrombin receptor-activating peptide, U46619, collagen, and arachidonic acid each caused the release of [3H]serotonin from dense granules, but only that elicited by low-dose collagen and arachidonic acid was inhibited by PD98059. Serotonin 118-127 TRAP Homo sapiens 10-46 9562184-4 1998 This decrease probably occurred via inhibition of GAT-2 or GAT-3 activity since their inhibitor, beta-alanine, induced a decrease in [3H]-GABA uptake in punches of sham-operated rats (-28%), but not in punches of 5,7-DHT-treated rats, demonstrating that serotonin terminal degeneration had already impaired the beta-alanine-sensitive component of GABA uptake. Serotonin 254-263 solute carrier family 6 member 11 Rattus norvegicus 59-64 9514827-0 1998 Comparison of more and less lipophilic serotonin (5HT1B/1D) agonists in a model of trigeminovascular nociception in cat. Serotonin 39-48 5-hydroxytryptamine receptor 1B Felis catus 50-55 9514208-3 1998 In this report, we tested the effect of intracranially infused serotonin-activated rat alpha1M (5HT-alpha1M) on the concentration of dopamine (DA) in the corpus striatum in vivo and the effect of 5HT-activated rat alpha1M and alpha2M on the choline acetyltransferase (ChAT) activity upon embryonic basal forebrain neurons in culture. Serotonin 63-72 choline O-acetyltransferase Rattus norvegicus 241-266 9468384-4 1998 We found that MASH-1 knockout mice have a greatly reduced number of C cells based on the lack of calcitonin and serotonin immunoreactivity. Serotonin 112-121 achaete-scute family bHLH transcription factor 1 Mus musculus 14-20 9720968-11 1998 (2) In the hypoglutamatergic state induced by MK-801, endogenous serotonin exerts a stimulatory effect on locomotion through an action at 5-HT2A receptors, an effect that is almost completely counterbalanced by a concomitant inhibitory impact on locomotion, mediated through stimulation of serotonin receptors other than 5-HT2A receptors. Serotonin 65-74 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 138-144 9720968-11 1998 (2) In the hypoglutamatergic state induced by MK-801, endogenous serotonin exerts a stimulatory effect on locomotion through an action at 5-HT2A receptors, an effect that is almost completely counterbalanced by a concomitant inhibitory impact on locomotion, mediated through stimulation of serotonin receptors other than 5-HT2A receptors. Serotonin 65-74 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 321-327 9414016-0 1998 Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan. Serotonin 12-21 RNA polymerase III subunit K Homo sapiens 70-74 9416904-6 1997 A significant correlation was noted between the serotonin-induced contractions and MLC phosphorylations. Serotonin 48-57 myosin light chain 1 Sus scrofa 83-86 9704050-3 1997 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) (from 25.2 to 29.9%), and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 231-240 interleukin 1 receptor antagonist Rattus norvegicus 114-153 9704050-3 1997 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) (from 25.2 to 29.9%), and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 231-240 interleukin 1 receptor antagonist Rattus norvegicus 155-161 9704050-3 1997 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) (from 25.2 to 29.9%), and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 242-245 interleukin 1 receptor antagonist Rattus norvegicus 114-153 9704050-3 1997 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) (from 25.2 to 29.9%), and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 242-245 interleukin 1 receptor antagonist Rattus norvegicus 155-161 9384224-6 1997 Serotonin-like activity was seen in in vitro functional assays including inhibition of forskolin-stimulated cAMP accumulation in human 5-HT1D receptor-transfected fibroblasts or eliciting vasoconstriction in isolated human pial arteries. Serotonin 0-9 5-hydroxytryptamine receptor 1D Homo sapiens 135-141 9387858-1 1997 The principal brain vesicular monoamine transporter (VMAT2) pumps monoamines including dopamine, norepinephrine, serotonin and histamine from neuronal cytoplasm into synaptic vesicles and is implicated in actions of certain psychostimulants and selective neurotoxins. Serotonin 113-122 solute carrier family 18 (vesicular monoamine), member 2 Mus musculus 53-58 9330437-6 1997 Finally, PCA-4230 also potentiated the forskolin- and sodium nitroprusside-inhibited serotonin release evoked by thrombin, probably related to the increased cyclic nucleotide level. Serotonin 85-94 prothrombin Oryctolagus cuniculus 113-121 9301661-11 1997 An evaluation for ability to stimulate phosphoinositide turnover as a measure of functional efficacy revealed that all the compounds were of approximately equal efficacy to serotonin in 5-HT2C receptors. Serotonin 173-182 5-hydroxytryptamine receptor 2C Homo sapiens 186-192 9379342-0 1997 Inhibition of hepatic tryptophan-2,3-dioxygenase: superior potency of melatonin over serotonin. Serotonin 85-94 tryptophan 2,3-dioxygenase Homo sapiens 22-48 9379342-1 1997 In view of the biogenic amine deficiency hypothesis of depression and the contentious claim that hepatic tryptophan-2,3-dioxygenase (TDO) is the major peripheral determinant of brain tryptophan, brain serotonin (5-HT), and ultimately melatonin, the regulation of TDO by melatonin and 5-HT is investigated and discussed. Serotonin 201-210 tryptophan 2,3-dioxygenase Homo sapiens 105-131 9379342-1 1997 In view of the biogenic amine deficiency hypothesis of depression and the contentious claim that hepatic tryptophan-2,3-dioxygenase (TDO) is the major peripheral determinant of brain tryptophan, brain serotonin (5-HT), and ultimately melatonin, the regulation of TDO by melatonin and 5-HT is investigated and discussed. Serotonin 201-210 tryptophan 2,3-dioxygenase Homo sapiens 133-136 9263606-7 1997 Serotonergic 5-HT2C receptors are likely to contribute to the synaptic plasticity observed in layer IV, since mesulergine, an antagonist of the 5-HT2C receptor, completely blocked synaptic modifications induced by the combination of low frequency stimulation and serotonin application. Serotonin 263-272 5-hydroxytryptamine receptor 2C Homo sapiens 13-19 9263606-7 1997 Serotonergic 5-HT2C receptors are likely to contribute to the synaptic plasticity observed in layer IV, since mesulergine, an antagonist of the 5-HT2C receptor, completely blocked synaptic modifications induced by the combination of low frequency stimulation and serotonin application. Serotonin 263-272 5-hydroxytryptamine receptor 2C Homo sapiens 144-150 9169451-9 1997 Unexpectedly, the 5-HT2A receptor is able to activate another signaling pathway; it triggers a rapid and transient tyrosine phosphorylation of Jak2 kinase in response to serotonin. Serotonin 170-179 Janus kinase 2 Rattus norvegicus 143-147 9122262-3 1997 To see if this effect of EEDQ was on the receptor itself, the binding of 5HT to 5HT2c receptors was studied in transfected HeLa cells. Serotonin 73-76 5-hydroxytryptamine receptor 2C Homo sapiens 80-85 9067310-1 1997 The aminotetralins, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and 7-OH-DPAT behave as preferential agonists at serotonin (5-HT)1A and dopamine D3 and D2 receptors, respectively. Serotonin 120-129 immunoglobulin heavy diversity 2-15 Homo sapiens 159-161 9030094-3 1997 In the present study, the effects of preformed inflammatory mediators (histamine and serotonin) on the induction and expression of MHC class II, E-selectin, and ICAM-1 molecules by human umbilical vein endothelial cells were examined. Serotonin 85-94 intercellular adhesion molecule 1 Homo sapiens 161-167 9238850-25 1997 By using the CREM-deficient mice and by analysis of the regulatory region of the gene encoding the serotonin NAT, we have established that ICER is responsible for the amplitude and rhythmicity of NAT and thus for the oscillation in the hormonal synthesis of melatonin. Serotonin 99-108 cAMP responsive element modulator Mus musculus 139-143 8922413-0 1996 Differential actions of serotonin, mediated by 5-HT1B and 5-HT2C receptors, on GABA-mediated synaptic input to rat substantia nigra pars reticulata neurons in vitro. Serotonin 24-33 5-hydroxytryptamine receptor 1B Rattus norvegicus 47-53 8922413-9 1996 Thus, serotonin can both depolarize and disinhibit SNr neurons via 5-HT2C and 5-HT1B receptors, respectively, but excitation may be limited by GABA released from axon collaterals. Serotonin 6-15 5-hydroxytryptamine receptor 1B Rattus norvegicus 78-84 8931011-1 1996 Patterns of co-localization of serotonin with glutamate decarboxylase (the synthetic enzyme for GABA) or each one of eight neuropeptides (calcitonin gene-related peptide, dynorphin, enkephalin, galanin, neuropeptide Y, neurotensin, substance P and somatostatin) were investigated with dual-colour confocal laser scanning microscopy in the lumbar spinal cords of three adult rats. Serotonin 31-40 glutamate-ammonia ligase Rattus norvegicus 46-69 8881517-9 1996 Furthermore, chronic treatment with FGF-2 also induced coronary vasospastic responses to serotonin and histamine and neointimal formation. Serotonin 89-98 fibroblast growth factor 2 Sus scrofa 36-41 8873272-1 1996 The 5-HT1B receptor has been proposed as a link in the relationship between serotonin and satiety. Serotonin 76-85 5-hydroxytryptamine receptor 1B Rattus norvegicus 4-10 8801661-4 1996 The development of the 5-Hydroxy Tryptamine ID (5HT1D)-agonist sumatriptan has changed the lives of many migraine sufferers. Serotonin 23-43 5-hydroxytryptamine receptor 1D Homo sapiens 48-53 8878061-9 1996 It is concluded that ethanol predominantly inhibits NMDA receptors containing a high proportion of the NMDAR2B subunit (as reflected by high sensitivity to ifenprodil), i.e. the NMDA receptors involved in stimulation of noradrenaline, 5-hydroxytryptamine and GABA release. Serotonin 235-254 glutamate ionotropic receptor NMDA type subunit 2B Rattus norvegicus 103-110 8925586-5 1996 The possibility that the platelet-derived product serotonin (5-HT) regulates expression of the thrombin receptor was examined in cultured rat aortic vascular smooth muscle cells. Serotonin 50-59 coagulation factor II (thrombin) receptor Rattus norvegicus 95-112 8792338-6 1996 The overall distribution of neurons expressing GTP cyclohydrolase I mRNA was observed to correspond exactly to the known distribution of the dopamine, norepinephrine/epinephrine and serotonin-containing cell groups. Serotonin 182-191 GTP cyclohydrolase 1 Rattus norvegicus 47-67 8792338-7 1996 Overall, a 30-fold range of GTP cyclohydrolase I mRNA expression was observed, with the transcript being significantly more abundant in serotonin than in dopamine or norepinephrine/epinephrine neurons. Serotonin 136-145 GTP cyclohydrolase 1 Rattus norvegicus 28-48 8792338-8 1996 Comparisons across serotonin cell groups indicated that neurons of the median raphe nucleus, caudal linear nucleus raphe (B8) and the dorsal raphe (B6/B7) expressed the highest levels of GTP cyclohydrolase I mRNA. Serotonin 19-28 GTP cyclohydrolase 1 Rattus norvegicus 187-207 8963648-1 1996 We have previously demonstrated alterations in serotonin metabolism within descending pathways following infusion of brain-derived neurotrophic factor (BDNF) into the midbrain, near the periaqueductal gray and dorsal and median raphe nuclei. Serotonin 47-56 brain-derived neurotrophic factor Rattus norvegicus 117-150 8963648-1 1996 We have previously demonstrated alterations in serotonin metabolism within descending pathways following infusion of brain-derived neurotrophic factor (BDNF) into the midbrain, near the periaqueductal gray and dorsal and median raphe nuclei. Serotonin 47-56 brain-derived neurotrophic factor Rattus norvegicus 152-156 8963648-9 1996 These results suggest that BDNF increased synthesis and/or turnover of serotonin, and to a lesser extent dopamine, in the mature rat forebrain. Serotonin 71-80 brain-derived neurotrophic factor Rattus norvegicus 27-31 8717440-0 1996 Effect of interleukin-1 receptor antagonist (IL-1RA) on histamine and serotonin release by rat basophilic leukemia cells (RBL-2H3) and peritoneal mast cells. Serotonin 70-79 interleukin 1 receptor antagonist Rattus norvegicus 45-51 8717440-3 1996 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 231-240 interleukin 1 receptor antagonist Rattus norvegicus 114-153 8717440-3 1996 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 231-240 interleukin 1 receptor antagonist Rattus norvegicus 155-161 8717440-3 1996 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 242-245 interleukin 1 receptor antagonist Rattus norvegicus 114-153 8717440-3 1996 In this report we provide evidence that rat basophilic leukemia cells (RBLC) cultured with a natural inhibitor of IL-1, interleukin-1 receptor antagonist (IL-1RA) (500 ng/ml) for 48 h, strongly inhibited the spontaneous release of serotonin (5HT) and histamine (from 22.50 to 43.49%), compared to untreated cells (control). Serotonin 242-245 interleukin 1 receptor antagonist Rattus norvegicus 155-161 8717440-6 1996 The present studies describe an additional biological activity of IL-1RA, inhibiting histamine and 5HT release from RBLC cultures. Serotonin 99-102 interleukin 1 receptor antagonist Rattus norvegicus 66-72 8598218-10 1996 c-src kinase overexpression reduced PDGF- and serotonin-mediated changes in Ca2+ signaling, indicating multiple targets of pp60c-src action. Serotonin 46-55 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 123-132 8573115-3 1996 Moreover the enzymatic activity of MAO-B towards phenylethylamine and tyramine is also suppressed after this immunoprecipitation, contrary to the MAO-A activity towards 5-hydroxy-tryptamine. Serotonin 169-189 monoamine oxidase B Homo sapiens 35-40 8788473-11 1996 Further supporting the relevance of 5-HT1B receptors to the activating effects of serotonin-releasing agents, MDMA exhibits reciprocal cross-tolerance with the 5-HT1B agonist RU 24969, but not with either 5-HT1A or 5-HT2 agonists or amphetamine. Serotonin 82-91 5-hydroxytryptamine receptor 1B Rattus norvegicus 36-42 8788473-11 1996 Further supporting the relevance of 5-HT1B receptors to the activating effects of serotonin-releasing agents, MDMA exhibits reciprocal cross-tolerance with the 5-HT1B agonist RU 24969, but not with either 5-HT1A or 5-HT2 agonists or amphetamine. Serotonin 82-91 5-hydroxytryptamine receptor 1B Rattus norvegicus 160-166 8788473-13 1996 The fact that the predominant effect of serotonin releasers is locomotor activation, apparently mediated via post-synaptic 5-HT1B receptors, suggests that some endogenous serotonergic systems may normally activate rather than suppress motor output. Serotonin 40-49 5-hydroxytryptamine receptor 1B Rattus norvegicus 123-129 11224400-4 1996 Extracellular hippocampal serotonin was higher (p < 0.05) during the first 40min of exercise than after 40min of being placed on the stationary treadmill, but this increase occurred only in those animals that learned more slowly and ran a shorter distance (1030+/-30m) and not in those that learned more rapidly and ran further (1150+/-20m). Serotonin 26-35 RAN, member RAS oncogene family Rattus norvegicus 236-239 11224400-4 1996 Extracellular hippocampal serotonin was higher (p < 0.05) during the first 40min of exercise than after 40min of being placed on the stationary treadmill, but this increase occurred only in those animals that learned more slowly and ran a shorter distance (1030+/-30m) and not in those that learned more rapidly and ran further (1150+/-20m). Serotonin 26-35 RAN, member RAS oncogene family Rattus norvegicus 319-322 8547642-0 1996 Recombinant scinderin, an F-actin severing protein, increases calcium-induced release of serotonin from permeabilized platelets, an effect blocked by two scinderin-derived actin-binding peptides and phosphatidylinositol 4,5-bisphosphate. Serotonin 89-98 scinderin Homo sapiens 12-21 8598478-0 1996 Secretion of IL-16 (lymphocyte chemoattractant factor) from serotonin-stimulated CD8+ T cells in vitro. Serotonin 60-69 CD8a molecule Homo sapiens 81-84 8598478-8 1996 Serotonin induced secretion of IL-16 from CD8+, not CD4+, T cells which did not require the de novo protein synthesis. Serotonin 0-9 CD8a molecule Homo sapiens 42-45 8831798-1 1996 Using selective monoamine uptake blockers and appropriate selective monoamine receptor antagonists, we have previously shown that cocaine enhances the frequency of 5-HT2A receptor-mediated 5-hydroxytryptophan (5-HTP)-induced head-twitch response (HTR) in mice via inhibition of serotonin uptake. Serotonin 278-287 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 164-179 8787824-0 1995 Interleukin-1 receptor antagonist increases survival in rat heatstroke by reducing hypothalamic serotonin release. Serotonin 96-105 interleukin 1 receptor antagonist Rattus norvegicus 0-33 8787824-5 1995 The data indicate that IL-1 ra increases survival during rat heatstroke by reducing hypothalamic serotonin release. Serotonin 97-106 interleukin 1 receptor antagonist Rattus norvegicus 23-30 7499362-2 1995 We have previously shown that the 14-3-3 protein binds with and activates phosphorylated tryptophan hydroxylase (TPH, the rate-limiting enzyme in the biosynthesis of neurotransmitter serotonin) and proposed that this activity might be mediated through the COOH-terminal acidic region of the 14-3-3 molecules. Serotonin 183-192 tryptophan hydroxylase 1 Rattus norvegicus 89-111 7499362-2 1995 We have previously shown that the 14-3-3 protein binds with and activates phosphorylated tryptophan hydroxylase (TPH, the rate-limiting enzyme in the biosynthesis of neurotransmitter serotonin) and proposed that this activity might be mediated through the COOH-terminal acidic region of the 14-3-3 molecules. Serotonin 183-192 tryptophan hydroxylase 1 Rattus norvegicus 113-116 8748393-5 1995 In vitro intrinsic activity at the 5-HT2C site was expressed as a fraction of the maximal PI hydrolysis response elicited by serotonin (5-HT). Serotonin 125-134 5-hydroxytryptamine receptor 2C Homo sapiens 35-41 8747793-0 1995 Dominant contribution of 5-hydroxytryptamine over thromboxane A2 in contractile response of rabbit isolated aortic preparation to thrombin activated platelets. Serotonin 25-44 prothrombin Oryctolagus cuniculus 130-138 8544984-0 1995 Induction of c-fos in rat forebrain by pharmacological manipulation of 5-hydroxytryptamine levels. Serotonin 71-90 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 13-18 8666386-2 1995 Tryptophan 2,3-dioxygenase is the rate-limiting enzyme in the catabolism of tryptophan, the precursor of serotonin. Serotonin 105-114 tryptophan 2,3-dioxygenase Homo sapiens 0-26 7664446-5 1995 In the presence of 5 mmol/L glucose, preincubation of cells for 30 minutes with 1 nmol/L insulin inhibited 10(-5) mol/L serotonin-induced contraction of individual cells by 62% (P < .01) and decreased the serotonin-stimulated component of Mn2+ influx by 78% (P < .05). Serotonin 120-129 insulin Canis lupus familiaris 89-96 7664446-5 1995 In the presence of 5 mmol/L glucose, preincubation of cells for 30 minutes with 1 nmol/L insulin inhibited 10(-5) mol/L serotonin-induced contraction of individual cells by 62% (P < .01) and decreased the serotonin-stimulated component of Mn2+ influx by 78% (P < .05). Serotonin 208-217 insulin Canis lupus familiaris 89-96 7664446-7 1995 Insulin lowered the serotonin-induced intracellular Ca2+ peak by 37% (P < .05), and phloridzin blocked this effect of insulin. Serotonin 20-29 insulin Canis lupus familiaris 0-7 7664446-9 1995 CONCLUSIONS: Since the effects of insulin on serotonin-stimulated Ca2+ transport, intracellular Ca2+ concentration, and contraction were dependent on glucose transport and were duplicated when glucose transport was stimulated by high extracellular glucose concentration rather than insulin per se, it is concluded that insulin-stimulated glucose transport is an early event that leads to decreased Ca2+ influx and contraction in vascular smooth muscle. Serotonin 45-54 insulin Canis lupus familiaris 34-41 7664446-9 1995 CONCLUSIONS: Since the effects of insulin on serotonin-stimulated Ca2+ transport, intracellular Ca2+ concentration, and contraction were dependent on glucose transport and were duplicated when glucose transport was stimulated by high extracellular glucose concentration rather than insulin per se, it is concluded that insulin-stimulated glucose transport is an early event that leads to decreased Ca2+ influx and contraction in vascular smooth muscle. Serotonin 45-54 insulin Canis lupus familiaris 282-289 7664446-9 1995 CONCLUSIONS: Since the effects of insulin on serotonin-stimulated Ca2+ transport, intracellular Ca2+ concentration, and contraction were dependent on glucose transport and were duplicated when glucose transport was stimulated by high extracellular glucose concentration rather than insulin per se, it is concluded that insulin-stimulated glucose transport is an early event that leads to decreased Ca2+ influx and contraction in vascular smooth muscle. Serotonin 45-54 insulin Canis lupus familiaris 282-289 8532190-4 1995 Application of submicromolar concentrations of 5-HT, 2,5,-dimethoxy-4- iodoamphetamine and alpha-methyl-5-HT significantly enhanced release of AChE, whereas 5-carboxamidotryptamine, sumatriptan, 2-methyl-5-HT and 5-methoxytryptamine were ineffective at a similar concentration range. Serotonin 47-51 acetylcholinesterase Cavia porcellus 143-147 7477434-0 1995 5-HT1-like and 5-HT2A receptors mediate 5-hydroxytryptamine-induced contraction of rabbit isolated mesenteric artery. Serotonin 40-59 5-hydroxytryptamine receptor 1B Oryctolagus cuniculus 0-10 7605351-9 1995 The differential effect of the three MAO-B inhibitors on synaptosome 5 HT uptake and release was confirmed by [14C]5HT uptake and liberation experiments with isolated rat platelets. Serotonin 115-118 monoamine oxidase B Rattus norvegicus 37-42 7779294-7 1995 It is concluded that serotonin, via 5-HT1B-1D receptors, may induce an elevation of the visual distractibility threshold by modulating directly the transmission of the primary visual signal. Serotonin 21-30 5-hydroxytryptamine receptor 1B Rattus norvegicus 36-42