PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25552400-11	2015	Neamine inhibited ANG-induced HUVEC and HeLa cell proliferation as well as nuclear translocation of ANG.	neamine	0-7	angiogenin	Homo sapiens	18-21
26170989-4	2015	The aim of the present study was to investigate whether neamine, a low toxicity angiogenin nuclear translocation inhibitor, has preferential anti-prostate cancer activity compared with cis-platinum (DDP) and the mechanisms involved.	neamine	56-63	angiogenin	Homo sapiens	80-90
26170989-5	2015	Immunofluorescence and MTT assays were used to observe the effect of neamine on the nuclear translocation of angiogenin and cell proliferation, and a PC-3 cell transplanted tumor model was used to investigate the in vivo activity of neamine and DDP.	neamine	69-76	angiogenin	Homo sapiens	109-119
26170989-9	2015	Neamine consistently reduced the expression of angiogenin and CD31 significantly, but no difference was found in Ki-67 expression compared with DDP.	neamine	0-7	angiogenin	Homo sapiens	47-57
26170989-9	2015	Neamine consistently reduced the expression of angiogenin and CD31 significantly, but no difference was found in Ki-67 expression compared with DDP.	neamine	0-7	platelet and endothelial cell adhesion molecule 1	Homo sapiens	62-66
25552400-11	2015	Neamine inhibited ANG-induced HUVEC and HeLa cell proliferation as well as nuclear translocation of ANG.	neamine	0-7	angiogenin	Homo sapiens	100-103
18029660-0	2007	Nucleobase modified neamines, their synthesis and binding specificity for HIV TAR RNA.	neamine	20-28	RNA binding motif protein 8A	Homo sapiens	78-81
24778013-0	2014	Neamine inhibits oral cancer progression by suppressing angiogenin-mediated angiogenesis and cancer cell proliferation.	neamine	0-7	angiogenin	Homo sapiens	56-66
24778013-3	2014	The aim of this study was to assess whether neamine, a blocker of nuclear translocation of angiogenin, possesses antitumor activity toward oral cancer.	neamine	44-51	angiogenin	Homo sapiens	91-101
24778013-7	2014	Neamine treatment resulted in a significant decrease in tumor angiogenesis, accompanied by a decrease in angiogenin- and proliferating cell nuclear antigen-positive cancer cells, especially of HSC-2 tumors.	neamine	0-7	angiogenin	Homo sapiens	105-115
24211797-3	2014	Neamine, an aminoglycoside antibiotic, blocks nuclear translocation of Angiogenin, thereby abolishing the biological activity of Angiogenin.	neamine	0-7	angiogenin	Rattus norvegicus	71-81
24211797-3	2014	Neamine, an aminoglycoside antibiotic, blocks nuclear translocation of Angiogenin, thereby abolishing the biological activity of Angiogenin.	neamine	0-7	angiogenin	Rattus norvegicus	129-139
24211797-11	2014	Using immunostaining, we found that Neamine treatment significantly decreased nuclear Angiogenin, nuclear factor kappa-light-chain-enhancer of activated B cells (NFkappaB) activity, advanced glycation endproducts receptor (RAGE) number, the positive area of toll-like receptor 4 (TLR4) and increased Angeopoietin-1 expression compared to T1DM-MCAo control rats.	neamine	36-43	angiogenin	Rattus norvegicus	86-96
24211797-11	2014	Using immunostaining, we found that Neamine treatment significantly decreased nuclear Angiogenin, nuclear factor kappa-light-chain-enhancer of activated B cells (NFkappaB) activity, advanced glycation endproducts receptor (RAGE) number, the positive area of toll-like receptor 4 (TLR4) and increased Angeopoietin-1 expression compared to T1DM-MCAo control rats.	neamine	36-43	advanced glycosylation end product-specific receptor	Rattus norvegicus	223-227
24211797-11	2014	Using immunostaining, we found that Neamine treatment significantly decreased nuclear Angiogenin, nuclear factor kappa-light-chain-enhancer of activated B cells (NFkappaB) activity, advanced glycation endproducts receptor (RAGE) number, the positive area of toll-like receptor 4 (TLR4) and increased Angeopoietin-1 expression compared to T1DM-MCAo control rats.	neamine	36-43	toll-like receptor 4	Rattus norvegicus	258-278
24211797-11	2014	Using immunostaining, we found that Neamine treatment significantly decreased nuclear Angiogenin, nuclear factor kappa-light-chain-enhancer of activated B cells (NFkappaB) activity, advanced glycation endproducts receptor (RAGE) number, the positive area of toll-like receptor 4 (TLR4) and increased Angeopoietin-1 expression compared to T1DM-MCAo control rats.	neamine	36-43	toll-like receptor 4	Rattus norvegicus	280-284
21135992-7	2010	Nuclear translocation of angiogenin was blocked by neamine, and angiogenin-induced cell proliferation was inhibited by neamine.	neamine	51-58	angiogenin	Homo sapiens	25-35
21135992-7	2010	Nuclear translocation of angiogenin was blocked by neamine, and angiogenin-induced cell proliferation was inhibited by neamine.	neamine	119-126	angiogenin	Homo sapiens	64-74
19327991-2	2009	The binding affinities of these derivatives to A site of 16S RNA and TAR RNA indicate that the modification on 5-hydroxyl of neamine by amino acid can enhance the binding affinity of neamine.	neamine	125-132	RNA binding motif protein 8A	Homo sapiens	69-72
19327991-2	2009	The binding affinities of these derivatives to A site of 16S RNA and TAR RNA indicate that the modification on 5-hydroxyl of neamine by amino acid can enhance the binding affinity of neamine.	neamine	183-190	RNA binding motif protein 8A	Homo sapiens	69-72
23986578-9	2013	These studies demonstrated that ANG played an essential role in KSHV latency maintenance and BCBL-1 cell survival in vivo, and targeting ANG function by neomycin/neamine to induce the apoptosis of cells latently infected with KSHV is an attractive therapeutic strategy against KSHV-associated malignancies.	neamine	162-169	angiogenin	Homo sapiens	137-140
19276260-0	2009	Neamine inhibits prostate cancer growth by suppressing angiogenin-mediated rRNA transcription.	neamine	0-7	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	55-65
19276260-2	2009	The purpose of this study is to assess the antitumor activity of neamine, a nontoxic degradation product of neomycin that blocks nuclear translocation of ANG.	neamine	65-72	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	154-157
19276260-7	2009	Neamine also prevents AKT-induced PIN formation as well as reverses fully developed PIN in murine prostate-restricted AKT mice, accompanied by a decrease in rRNA synthesis, cell proliferation, and angiogenesis and an increase in prostate epithelial cell apoptosis.	neamine	0-7	thymoma viral proto-oncogene 1	Mus musculus	22-25
19276260-7	2009	Neamine also prevents AKT-induced PIN formation as well as reverses fully developed PIN in murine prostate-restricted AKT mice, accompanied by a decrease in rRNA synthesis, cell proliferation, and angiogenesis and an increase in prostate epithelial cell apoptosis.	neamine	0-7	thymoma viral proto-oncogene 1	Mus musculus	118-121
18829307-5	2008	It indicates that conjugates 12a-c and 14a-d interact with 16S, 18S RNA at the same level as that of neamine, 14a and 14d show about twofold binding affinities to TAR RNA compared to that of neamine.	neamine	101-108	RNA binding motif protein 8A	Homo sapiens	163-166
18829307-6	2008	However, the neamine-dinucleotide conjugates 8a-g exhibit very weak binding affinities to 16S, 18S, and TAR RNA, computer modelling results that negative-negative electrostatic repulsion of phosphate group in compound 8a-g and RNA leads to a sharp decrease of the binding affinities compared with that of neamine, neamine-nucleoside and neamine-PNA conjugates.	neamine	13-20	RNA binding motif protein 8A	Homo sapiens	104-107
18029660-3	2007	The binding affinity of neamine derivatives having a nucleobase at the closer position to neamine does not depend on the base, but having farther position has shown base specificity for TAR binding.	neamine	24-31	RNA binding motif protein 8A	Homo sapiens	186-189
18029660-1	2007	Twenty neamine derivatives having a nucleobase, adenine, cytosine, guanine or thimine with a lysine or an argine as a linker and, also, without linker were synthesized and their binding specificity for HIV TAR RNA was studied.	neamine	7-14	RNA binding motif protein 8A	Homo sapiens	206-209
18029660-2	2007	Any nucleobase modification on neamine enhanced their binding affinities for TAR RNA.	neamine	31-38	RNA binding motif protein 8A	Homo sapiens	77-80
12852970-5	2003	Utilizing the smaller tripeptide platform, "Fmoc-Glu-Xxx-Leu-amide" we demonstrate herein that several of the low affinity hexapeptide-expressed pTyr mimetics exhibit high PTP1B affinity within the context of the tripeptide platform.	neamine	53-56	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	172-177
16361562-4	2005	EXPERIMENTAL DESIGN: The effect of neamine on the nuclear translocation of angiogenin was examined by means of immunofluorescence and Western blotting.	neamine	35-42	angiogenin	Homo sapiens	75-85
16361562-6	2005	RESULTS: Neamine effectively blocked the nuclear translocation of angiogenin in endothelial cells and inhibited angiogenin-induced cell proliferation.	neamine	9-16	angiogenin	Homo sapiens	66-76
16361562-6	2005	RESULTS: Neamine effectively blocked the nuclear translocation of angiogenin in endothelial cells and inhibited angiogenin-induced cell proliferation.	neamine	9-16	angiogenin	Homo sapiens	112-122
16361562-10	2005	CONCLUSION: These results suggest that the nontoxic aminoglycoside antibiotic neamine is an effective inhibitor of nuclear translocation of angiogenin and may serve as an inhibitor for angiogenin-induced angiogenesis and cancer progression.	neamine	78-85	angiogenin	Homo sapiens	140-150
16361562-10	2005	CONCLUSION: These results suggest that the nontoxic aminoglycoside antibiotic neamine is an effective inhibitor of nuclear translocation of angiogenin and may serve as an inhibitor for angiogenin-induced angiogenesis and cancer progression.	neamine	78-85	angiogenin	Homo sapiens	185-195
16153833-0	2005	Neamine dimers targeting the HIV-1 TAR RNA.	neamine	0-7	RNA binding motif protein 8A	Homo sapiens	35-38
16153833-2	2005	Neomycin also binds strongly to HIV TAR and RRE RNA through the predominant interactions of its neamine core.	neamine	96-103	RNA binding motif protein 8A	Homo sapiens	36-39
26838745-4	2016	MTT assay was used to observe the effect of neamine on angiogenin (ANG)-induced AsPC-1 cell proliferation.	neamine	44-51	angiogenin	Homo sapiens	55-65
29661878-5	2018	We find that APH(2"")-Ia maintains a preferred mode of binding aminoglycosides by using the conserved neamine rings when possible, with flexibility that allows it to accommodate additional rings.	neamine	102-109	acylaminoacyl-peptide hydrolase	Homo sapiens	13-16
27940282-1	2017	Neamine, an inhibitor of angiogenin (ANG), is a new investigative anticancer drug currently in preclinical stage.	neamine	0-7	angiogenin	Rattus norvegicus	25-35
27940282-1	2017	Neamine, an inhibitor of angiogenin (ANG), is a new investigative anticancer drug currently in preclinical stage.	neamine	0-7	angiogenin	Rattus norvegicus	37-40
27940282-12	2017	These results suggest that neamine is a specific ANG inhibitor with low toxicity and high anti-liver cancer efficacy.	neamine	27-34	angiogenin	Rattus norvegicus	49-52
12617917-1	2003	The syntheses of (+)-neamine 1, (-)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics.	neamine	17-28	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	44-49
12617917-1	2003	The syntheses of (+)-neamine 1, (-)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics.	neamine	17-28	solute carrier family 29 member 2	Homo sapiens	85-90
12617917-1	2003	The syntheses of (+)-neamine 1, (-)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics.	neamine	17-28	solute carrier family 29 member 3	Homo sapiens	95-100
12617917-1	2003	The syntheses of (+)-neamine 1, (-)-neamine ent-1 and their positional isomers 2, 3, ent-2 and ent-3 are reported as potential new scaffolds for novel aminoglycoside antibiotics.	neamine	32-43	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	44-49
30477891-1	2019	Synthetic neamine mimetics have been evaluated for binding to the HIV-1 Rev response element.	neamine	10-17	Rev	Human immunodeficiency virus 1	72-75
30060789-9	2018	Progranulin-induced migration and invasion were inhibited by neamine.	neamine	61-68	granulin precursor	Homo sapiens	0-11
27882181-3	2016	In the present study, the role of angiogenin in the human alloreactive immune response was evaluated using mixed lymphocyte reactions (MLRs) and neamine, an inhibitor of angiogenin nuclear translocation.	neamine	145-152	angiogenin	Homo sapiens	170-180
27882181-5	2016	The addition of neamine had no effect on cell proliferation, but did significantly (P<0.001) increase expression of Bcl-2-associated X protein and protein levels of activated caspase-3 in CD4+ T-cells isolated from the MLRs, indicating that angiogenin reduces apoptosis.	neamine	16-23	BCL2 apoptosis regulator	Homo sapiens	119-124
27882181-5	2016	The addition of neamine had no effect on cell proliferation, but did significantly (P<0.001) increase expression of Bcl-2-associated X protein and protein levels of activated caspase-3 in CD4+ T-cells isolated from the MLRs, indicating that angiogenin reduces apoptosis.	neamine	16-23	caspase 3	Homo sapiens	178-187
27882181-5	2016	The addition of neamine had no effect on cell proliferation, but did significantly (P<0.001) increase expression of Bcl-2-associated X protein and protein levels of activated caspase-3 in CD4+ T-cells isolated from the MLRs, indicating that angiogenin reduces apoptosis.	neamine	16-23	CD4 molecule	Homo sapiens	191-194
27882181-5	2016	The addition of neamine had no effect on cell proliferation, but did significantly (P<0.001) increase expression of Bcl-2-associated X protein and protein levels of activated caspase-3 in CD4+ T-cells isolated from the MLRs, indicating that angiogenin reduces apoptosis.	neamine	16-23	angiogenin	Homo sapiens	244-254
26838745-4	2016	MTT assay was used to observe the effect of neamine on angiogenin (ANG)-induced AsPC-1 cell proliferation.	neamine	44-51	angiogenin	Homo sapiens	67-70
26838745-8	2016	It was found that neamine blocked the nuclear translocation of ANG effectively and inhibited ANG-induced AsPC-1 cell proliferation in a dose-dependent manner.	neamine	18-25	angiogenin	Homo sapiens	63-66
26838745-8	2016	It was found that neamine blocked the nuclear translocation of ANG effectively and inhibited ANG-induced AsPC-1 cell proliferation in a dose-dependent manner.	neamine	18-25	angiogenin	Homo sapiens	93-96
26838745-10	2016	Consistently, neamine reduced the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.	neamine	14-21	angiogenin	Homo sapiens	55-58
26838745-10	2016	Consistently, neamine reduced the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.	neamine	14-21	platelet and endothelial cell adhesion molecule 1	Homo sapiens	70-74