PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 35562805-1 2022 BACKGROUND AND AIMS: Clarifying the association between 5-methyltetrahydrofolate and homocysteine and the effect pattern of methylene tetrahydrofolate reductase (MTHFR C677T) may contribute to the management of homocysteine and may serve as a significant reference for a randomized controlled trial of 5-methyltetrahydrofolate intervention. 5-methyltetrahydrofolate 302-326 methylenetetrahydrofolate reductase Homo sapiens 162-167 35562805-0 2022 Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study. 5-methyltetrahydrofolate 26-50 methylenetetrahydrofolate reductase Homo sapiens 120-125 35562805-9 2022 CONCLUSIONS: Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was <= 10 ng/mL, and this association was modified by MTHFR C677T. 5-methyltetrahydrofolate 85-109 methylenetetrahydrofolate reductase Homo sapiens 282-287 35562805-9 2022 CONCLUSIONS: Our data showed a non-linear association between serum homocysteine and 5-methyltetrahydrofolate among Chinese hypertensive adults, however, it could be inversely linearly fitted when serum 5-methyltetrahydrofolate was <= 10 ng/mL, and this association was modified by MTHFR C677T. 5-methyltetrahydrofolate 203-227 methylenetetrahydrofolate reductase Homo sapiens 282-287 35351926-7 2022 Three drugs-amprenavir, levomefolic acid, and calcipotriol-were predicted to bind to 3 different sites on the spike protein, domperidone to the Mac1 domain of the non-structural protein (Nsp) 3, avanafil to Nsp15, and nintedanib to the nucleocapsid protein involved in packaging the viral RNA. 5-methyltetrahydrofolate 24-40 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 110-115 2671982-1 1989 Methionine synthase, which catalyzes the reaction, 5-methyltetrahydrofolate (5-CH3-H4PteGlu) + homocysteine----methionine + tetrahydrofolate, was detected and partially purified from the human malarial parasite, Plasmodium falciparum (K1 isolate). 5-methyltetrahydrofolate 51-75 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 2803957-0 1989 Evidence for CSF accumulation of 5-methyltetrahydrofolate during repeated courses of methotrexate plus folinic acid rescue. 5-methyltetrahydrofolate 33-57 colony stimulating factor 2 Homo sapiens 13-16 35351926-7 2022 Three drugs-amprenavir, levomefolic acid, and calcipotriol-were predicted to bind to 3 different sites on the spike protein, domperidone to the Mac1 domain of the non-structural protein (Nsp) 3, avanafil to Nsp15, and nintedanib to the nucleocapsid protein involved in packaging the viral RNA. 5-methyltetrahydrofolate 24-40 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 163-193 2878641-1 1986 The present study examined the effect of human milk folate binding protein (FBP) on the intestinal transport of 5-methyltetrahydrofolate (5-CH3H4PteGlu). 5-methyltetrahydrofolate 112-136 folate receptor beta Homo sapiens 76-79 3146255-0 1988 [Inhibition of muscle glycogen phosphorylase b by 5-methyltetrahydrofolic acid, 3"-chloro- and 3",6"-dichloromethotrexates]. 5-methyltetrahydrofolate 50-78 LOW QUALITY PROTEIN: glycogen phosphorylase, brain form Oryctolagus cuniculus 22-46 3146255-1 1988 Inhibition of rabbit skeletal muscle glycogen phosphorylase b by 5-methyl-5,6,7,8-tetrahydrofolic acid, 3"-chloro- and 3",5"-dichloromethotrexates has been studied. 5-methyltetrahydrofolate 65-102 LOW QUALITY PROTEIN: glycogen phosphorylase, brain form Oryctolagus cuniculus 37-61 3146255-5 1988 The antagonism between 5-methyl-5,6,7,8-tetrahydrofolic acid, 3"-chloro- and 3",5"-dichloromethotrexates, on the one hand, and AMP and FMN, on the other, is revealed for combined action of modifiers on glycogen phosphorylase b. 5-methyltetrahydrofolate 23-60 LOW QUALITY PROTEIN: glycogen phosphorylase, brain form Oryctolagus cuniculus 202-226 3395609-4 1988 Uptake of MTHF by the membrane vesicles was strongly enhanced by FBP within the pH range 4.5-6.5, with an optimum at pH 5-5.5. 5-methyltetrahydrofolate 10-14 folate receptor alpha Bos taurus 65-68 3395609-6 1988 Both the initial rate of MTHF uptake and uptake of MTHF at equilibrium were markedly increased in the presence of FBP. 5-methyltetrahydrofolate 25-29 folate receptor alpha Bos taurus 114-117 3395609-6 1988 Both the initial rate of MTHF uptake and uptake of MTHF at equilibrium were markedly increased in the presence of FBP. 5-methyltetrahydrofolate 51-55 folate receptor alpha Bos taurus 114-117 3395609-8 1988 Uptake of MTHF by brush-border-membrane vesicles was maximal when the molar ratio FBP:MTHF was 1.0-2.5. 5-methyltetrahydrofolate 10-14 folate receptor alpha Bos taurus 82-85 3110521-6 1987 The investigation of the folate metabolite pattern (determined by HPLC) showed that 5-CHO-THF and 5-methyl-tetrahydrofolic acid (5-CH3-THF) were the main metabolites in untreated mice. 5-methyltetrahydrofolate 98-127 thin fur Mus musculus 135-138 3086647-2 1986 The activity of hepatic methylenetetrahydrofolate reductase, which plays a critical role in the regulation of liver folate metabolism, is suppressed in these animals, resulting in decreased 5-methyltetrahydrofolate synthesis. 5-methyltetrahydrofolate 190-214 methylenetetrahydrofolate reductase Rattus norvegicus 24-59 3948189-3 1986 In this study, MTHF was used for protection from toxicity following larger doses of MTX than previously studied, doses which could not be tolerated without effective "rescue." 5-methyltetrahydrofolate 15-19 metaxin 1 Homo sapiens 84-87 3948189-8 1986 Since ten of the treatments consisted of 12 and 24 g of MTX, doses potentially fatal without rescue, MTHF is an effective agent for prevention of MTX toxicity. 5-methyltetrahydrofolate 101-105 metaxin 1 Homo sapiens 56-59 3948189-8 1986 Since ten of the treatments consisted of 12 and 24 g of MTX, doses potentially fatal without rescue, MTHF is an effective agent for prevention of MTX toxicity. 5-methyltetrahydrofolate 101-105 metaxin 1 Homo sapiens 146-149 6350015-1 1983 The activities of 5-methyltetrahydrofolate (5-CH3-THF)-related enzymes [5-CH3-THF homocysteine methyltransferase and 5,10-methylenetetrahydrofolate (5,10-CH2-THF) reductase] and DNA polymerase alpha were measured in normal and malignant hematopoietic cells. 5-methyltetrahydrofolate 18-42 DNA polymerase alpha 1, catalytic subunit Homo sapiens 178-198 6602086-2 1983 Biochemical investigations show a decreased bioavailability of 5-methyl-tetrahydrofolic acid in vitamin B12 deficient human cell cultures and bone marrow cells. 5-methyltetrahydrofolate 63-92 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 104-107 6602086-4 1983 This so-called methyl-folate-trap results in a functional folic acid deficiency which is the pathogenetic principle of the defect in the cell proliferation in patients with vitamin B12 deficiency. 5-methyltetrahydrofolate 15-28 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 181-184 7437406-6 1980 The protection of haemopoiesis from vitamin B12 deficiency in the bat is probably related to the presence in the bat of separate pools of methylfolate and tetrahydrofolate, which enables the bat to overcome the trapping of methylfolate attendant on vitamin B12 deficiency. 5-methyltetrahydrofolate 138-150 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 44-47 7437406-6 1980 The protection of haemopoiesis from vitamin B12 deficiency in the bat is probably related to the presence in the bat of separate pools of methylfolate and tetrahydrofolate, which enables the bat to overcome the trapping of methylfolate attendant on vitamin B12 deficiency. 5-methyltetrahydrofolate 138-150 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 257-260 7437406-6 1980 The protection of haemopoiesis from vitamin B12 deficiency in the bat is probably related to the presence in the bat of separate pools of methylfolate and tetrahydrofolate, which enables the bat to overcome the trapping of methylfolate attendant on vitamin B12 deficiency. 5-methyltetrahydrofolate 223-235 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 44-47 33063250-2 2021 The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their properties with those of the previously established folic acid-based [177Lu]Lu-OxFol-1. 5-methyltetrahydrofolate 96-120 albumin Mus musculus 53-60 15258-7 1977 The cytosolic binder cochromatographed with N5-methyltetrahydrofolate:homocysteine methyltransferase activity (5-methyltetrahydropteroyl-L-glutamate:L-homocysteine S-methyltransferase, EC 2.1.1.13); the mitochondrial one with methylmalonyl CoA mutase activity (methylmalonyl-CoA CoA-carbonylmutase, EC 5.4.99.2). 5-methyltetrahydrofolate 44-69 methylmalonyl-CoA mutase Rattus norvegicus 226-250 4452225-0 1974 The effect of vitamin B12 deficiency on methylfolate metabolism and pteroylpolyglutamate synthesis in human cells. 5-methyltetrahydrofolate 40-52 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 22-25 33450645-1 2021 An electrochemical deposition method was used to fabricate a gold nanoflower (AuNF) and carbon nanoparticle (CNP) modified carbon paper (CP) sensor (AuNFs-CNPs/CP) for the low-cost detection of 5-methyltetrahydrofolate (5-mTHF) in egg yolk. 5-methyltetrahydrofolate 194-218 ceruloplasmin Homo sapiens 137-139 33450645-1 2021 An electrochemical deposition method was used to fabricate a gold nanoflower (AuNF) and carbon nanoparticle (CNP) modified carbon paper (CP) sensor (AuNFs-CNPs/CP) for the low-cost detection of 5-methyltetrahydrofolate (5-mTHF) in egg yolk. 5-methyltetrahydrofolate 194-218 ceruloplasmin Homo sapiens 160-162 33450645-1 2021 An electrochemical deposition method was used to fabricate a gold nanoflower (AuNF) and carbon nanoparticle (CNP) modified carbon paper (CP) sensor (AuNFs-CNPs/CP) for the low-cost detection of 5-methyltetrahydrofolate (5-mTHF) in egg yolk. 5-methyltetrahydrofolate 220-226 ceruloplasmin Homo sapiens 137-139 33450645-5 2021 The AuNFs-CNPs/CP sensor detected 5-mTHF concentrations in the ranges from 1 to 5 mg L-1 and 1-20 mug L-1, with an excellent limit of detection of 1 mug L-1 and good selectivity toward 5-mTHF, when compared to other potentially interfering molecules in samples. 5-methyltetrahydrofolate 34-40 ceruloplasmin Homo sapiens 15-17 33450645-5 2021 The AuNFs-CNPs/CP sensor detected 5-mTHF concentrations in the ranges from 1 to 5 mg L-1 and 1-20 mug L-1, with an excellent limit of detection of 1 mug L-1 and good selectivity toward 5-mTHF, when compared to other potentially interfering molecules in samples. 5-methyltetrahydrofolate 185-191 ceruloplasmin Homo sapiens 15-17 33450645-6 2021 The AuNFs-CNPs/CP sensor was also used to detect 5-mTHF in folate-rich, and was found to be twice than that of ordinary egg yolk. 5-methyltetrahydrofolate 49-55 ceruloplasmin Homo sapiens 15-17 1197918-1 1975 In the presence of 5-methoxytryptamine (5-MeOT), 5-methyltetrahydrofolic acid (5-MTHF) yields 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeOTHbetaC) in rat brain extracts, possibly via formaldehyde formation catalyzed by methylenetetrahydrofolate reductase. 5-methyltetrahydrofolate 49-77 methylenetetrahydrofolate reductase Rattus norvegicus 225-260 1197918-1 1975 In the presence of 5-methoxytryptamine (5-MeOT), 5-methyltetrahydrofolic acid (5-MTHF) yields 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeOTHbetaC) in rat brain extracts, possibly via formaldehyde formation catalyzed by methylenetetrahydrofolate reductase. 5-methyltetrahydrofolate 79-85 methylenetetrahydrofolate reductase Rattus norvegicus 225-260 33925570-7 2021 Hypothalamic mRNA expression of leptin receptor (ObRb) was lower, and of suppressor of cytokine signaling-3 (Socs3) was higher in the 5X-MTHF offspring (p < 0.05), suggesting central leptin dysregulation. 5-methyltetrahydrofolate 137-141 suppressor of cytokine signaling 3 Rattus norvegicus 73-107 33925570-7 2021 Hypothalamic mRNA expression of leptin receptor (ObRb) was lower, and of suppressor of cytokine signaling-3 (Socs3) was higher in the 5X-MTHF offspring (p < 0.05), suggesting central leptin dysregulation. 5-methyltetrahydrofolate 137-141 suppressor of cytokine signaling 3 Rattus norvegicus 109-114 33920562-3 2021 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, which produces a methyl donor for the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 154-178 methylenetetrahydrofolate reductase Homo sapiens 0-41 33920562-3 2021 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, which produces a methyl donor for the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 154-178 methylenetetrahydrofolate reductase Homo sapiens 43-48 33063250-2 2021 The aim of this study was to evaluate a new class of albumin-binding radioconjugates comprising 5-methyltetrahydrofolate (5-MTHF) as a targeting agent and to compare their properties with those of the previously established folic acid-based [177Lu]Lu-OxFol-1. 5-methyltetrahydrofolate 122-128 albumin Mus musculus 53-60 33189822-3 2021 MAIN METHODS: THH were treated with p70-S6K1 inhibitor and analyzed for cell viability, cell cycle distribution, specific marker protein expression by western blot, and tumor inhibition in a xenograft mouse model. 5-methyltetrahydrofolate 14-17 interleukin 2 receptor, beta chain Mus musculus 36-39 33189822-3 2021 MAIN METHODS: THH were treated with p70-S6K1 inhibitor and analyzed for cell viability, cell cycle distribution, specific marker protein expression by western blot, and tumor inhibition in a xenograft mouse model. 5-methyltetrahydrofolate 14-17 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 40-44 33189822-10 2021 A xenograft tumor model, generated from implanted THH in nude mice, following intraperitoneal injection of S6K1 inhibitor prevented further tumor growth. 5-methyltetrahydrofolate 50-53 ribosomal protein S6 kinase, polypeptide 1 Mus musculus 107-111 33375730-8 2020 Both doses of the MTHF diets led to 8% higher food intake and associated with lower plasma leptin at parturition, but higher leptin at 19-weeks and insulin resistance at 1-week post-weaning. 5-methyltetrahydrofolate 18-22 leptin Rattus norvegicus 91-97 33375730-8 2020 Both doses of the MTHF diets led to 8% higher food intake and associated with lower plasma leptin at parturition, but higher leptin at 19-weeks and insulin resistance at 1-week post-weaning. 5-methyltetrahydrofolate 18-22 leptin Rattus norvegicus 125-131 32289469-2 2020 The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl). 5-methyltetrahydrofolate 112-136 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 55-74 33426516-6 2021 L-methylfolate and methylcobalamin supplementation merits further study in WWE who have MTHFR mutations, fertility, recurrent miscarriage and or depression histories. 5-methyltetrahydrofolate 0-14 methylenetetrahydrofolate reductase Homo sapiens 88-93 33263678-3 2020 The L-methylfolate was prescribed as an adjuvant for the treatment of depression in a patient with the methylenetetrahydrofolate reductase gene polymorphism (MTHFR). 5-methyltetrahydrofolate 4-18 methylenetetrahydrofolate reductase Homo sapiens 103-138 33263678-3 2020 The L-methylfolate was prescribed as an adjuvant for the treatment of depression in a patient with the methylenetetrahydrofolate reductase gene polymorphism (MTHFR). 5-methyltetrahydrofolate 4-18 methylenetetrahydrofolate reductase Homo sapiens 158-163 33105619-11 2020 This variation induces an altered folate receptor alpha protein and underlines the role of a disulfide bond: Cys66-Cys109, essential to transport 5-MTHF into the central nervous system. 5-methyltetrahydrofolate 146-152 folate receptor alpha Homo sapiens 34-55 32363523-8 2020 The mRNA and protein levels of TNF-alpha, IFN-gamma, and IL-17A were lower in the THH-treated group than in the NS group (P < 0.05). 5-methyltetrahydrofolate 82-85 tumor necrosis factor Mus musculus 31-40 32363523-8 2020 The mRNA and protein levels of TNF-alpha, IFN-gamma, and IL-17A were lower in the THH-treated group than in the NS group (P < 0.05). 5-methyltetrahydrofolate 82-85 interferon gamma Mus musculus 42-51 32363523-8 2020 The mRNA and protein levels of TNF-alpha, IFN-gamma, and IL-17A were lower in the THH-treated group than in the NS group (P < 0.05). 5-methyltetrahydrofolate 82-85 interleukin 17A Mus musculus 57-63 32363523-10 2020 The mechanism of THH in the treatment of CIA may be through the inhibition of the NF-kB-STAT3-IL-17 pathway, which also requires further experimental investigation. 5-methyltetrahydrofolate 17-20 signal transducer and activator of transcription 3 Mus musculus 88-93 32363523-10 2020 The mechanism of THH in the treatment of CIA may be through the inhibition of the NF-kB-STAT3-IL-17 pathway, which also requires further experimental investigation. 5-methyltetrahydrofolate 17-20 interleukin 17A Mus musculus 94-99 32289469-2 2020 The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl). 5-methyltetrahydrofolate 112-136 Cbl proto-oncogene Homo sapiens 210-213 32289469-2 2020 The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl). 5-methyltetrahydrofolate 138-149 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 55-74 32289469-2 2020 The endogenous synthesis of methionine is catalyzed by methionine synthase, which transfers the methyl group of 5-methyltetrahydrofolate (5-methylTHF) to homocysteine in the presence of vitamin B12 (cobalamin, cbl). 5-methyltetrahydrofolate 138-149 Cbl proto-oncogene Homo sapiens 210-213 32131654-2 2020 The gas inhibits vitamin B12 dependent-methionine synthase, which converts L-homocysteine and 5-methyltetrahydrofolate to L-methionine and tetrahydrofolate, respectively, via a methylation process. 5-methyltetrahydrofolate 94-118 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 17-58 31363484-17 2019 Conclusion: We report a series of diabetic and hypertensive retinopathy cases with MTHFR polymorphisms and the improvement of retinal microvasculature (mainly MAs) in serial fundus photography after taking a medical food or supplement containing L-methylfolate and vitamin D. 5-methyltetrahydrofolate 246-260 methylenetetrahydrofolate reductase Homo sapiens 83-88 32145452-1 2020 OBJECTIVE: MTHFR SNPs (Methylene Tetrahydrofolate reductase Single Nucleotide polymorphisms) are biochemical modifications decreasing the capacity to form 5 MTHF 5 methyltetrahydrofolate (5MTHF). 5-methyltetrahydrofolate 188-193 methylenetetrahydrofolate reductase Homo sapiens 11-16 32145452-10 2020 Some simple therapeutic options can be proposed : they are based on the use of 5MTHF (5MethyleneTetraHydroFolate) the compound downstream the MTHFR. 5-methyltetrahydrofolate 79-84 methylenetetrahydrofolate reductase Homo sapiens 142-147 32150984-5 2020 Compared to untreated cells, treatment of C2C12 cells with AA at 100 microM resulted in enhanced concentrations of folic acid (2.5-fold) and 5-methyl-tetrahydrofolate (5-methyl-THF, 10-fold increase) whereas the relative concentrations of 10-formyl-tetrahydrofolate decreased by >90% upon AA pretreatment, indicative of increased utilization for the biosynthesis of active THF metabolites. 5-methyltetrahydrofolate 141-166 thin fur Mus musculus 177-180 31472292-0 2020 IgE-mediated anaphylactic reaction against free synthetic folic acid and methyl folate. 5-methyltetrahydrofolate 73-86 immunoglobulin heavy constant epsilon Homo sapiens 0-3 31446167-0 2020 5-Methyltetrahydrofolate reduces blood homocysteine level significantly in C677T methyltetrahydrofolate reductase single-nucleotide polymorphism carriers consulting for infertility. 5-methyltetrahydrofolate 0-24 methylenetetrahydrofolate reductase Homo sapiens 81-113 31446167-1 2020 PURPOSE: Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to Methionine. 5-methyltetrahydrofolate 140-164 methylenetetrahydrofolate reductase Homo sapiens 9-41 31446167-1 2020 PURPOSE: Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to Methionine. 5-methyltetrahydrofolate 140-164 methylenetetrahydrofolate reductase Homo sapiens 43-48 31446167-1 2020 PURPOSE: Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to Methionine. 5-methyltetrahydrofolate 166-172 methylenetetrahydrofolate reductase Homo sapiens 9-41 31446167-1 2020 PURPOSE: Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to Methionine. 5-methyltetrahydrofolate 166-172 methylenetetrahydrofolate reductase Homo sapiens 43-48 31446167-11 2020 CONCLUSIONS: Couples with a long history of infertility should be analysed for MTHFR SNP and homocysteine and should be treated with physiological doses of 5-MTHF instead of high doses of folic acid. 5-methyltetrahydrofolate 156-162 methylenetetrahydrofolate reductase Homo sapiens 79-84 31478270-12 2019 Low folic acid and high 5-MTHF+SST reduced the number of mature new neurons in the ventral hippocampus (BrdU/NeuN-positive cells) compared to folate deficient controls. 5-methyltetrahydrofolate 24-30 RNA binding fox-1 homolog 3 Rattus norvegicus 109-113 30693532-5 2019 Disruption of methionine synthase has wide-ranging implications for all methylation-dependent reactions, including epigenetic modification, but also for the intracellular folate pathway, since methionine synthase uses 5-methyltetrahydrofolate as a one-carbon donor. 5-methyltetrahydrofolate 218-242 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 14-33 30693532-5 2019 Disruption of methionine synthase has wide-ranging implications for all methylation-dependent reactions, including epigenetic modification, but also for the intracellular folate pathway, since methionine synthase uses 5-methyltetrahydrofolate as a one-carbon donor. 5-methyltetrahydrofolate 218-242 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 193-212 31497444-1 2019 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine re-methylation to methionine. 5-methyltetrahydrofolate 106-130 methylenetetrahydrofolate reductase Homo sapiens 0-35 31497444-1 2019 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine re-methylation to methionine. 5-methyltetrahydrofolate 106-130 methylenetetrahydrofolate reductase Homo sapiens 37-42 30406447-0 2019 A successful treatment with 5 methyltetrahydrofolate of a 677 TT MTHFR woman suffering premature ovarian insufficiency post a NHL (non-Hodgkin"s lymphoma) and RPL (repeat pregnancy losses). 5-methyltetrahydrofolate 28-52 methylenetetrahydrofolate reductase Homo sapiens 65-70 30726997-4 2019 Within one-carbon metabolism, methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 150-174 methylenetetrahydrofolate reductase Mus musculus 30-65 30726997-4 2019 Within one-carbon metabolism, methylenetetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 150-174 methylenetetrahydrofolate reductase Mus musculus 67-72 30408316-2 2019 A common variant in methylenetetrahydrofolate reductase (MTHFR 677C T) causes mild MTHFR deficiency with lower 5-methyltetrahydrofolate for methylation reactions. 5-methyltetrahydrofolate 111-135 methylenetetrahydrofolate reductase Mus musculus 20-55 30408316-2 2019 A common variant in methylenetetrahydrofolate reductase (MTHFR 677C T) causes mild MTHFR deficiency with lower 5-methyltetrahydrofolate for methylation reactions. 5-methyltetrahydrofolate 111-135 methylenetetrahydrofolate reductase Mus musculus 57-62 30408316-2 2019 A common variant in methylenetetrahydrofolate reductase (MTHFR 677C T) causes mild MTHFR deficiency with lower 5-methyltetrahydrofolate for methylation reactions. 5-methyltetrahydrofolate 111-135 methylenetetrahydrofolate reductase Mus musculus 83-88 30391174-11 2019 The enzymes encoded by betaine-homocysteine methyltransferase (BHMT) and 5-methyltetrahydrofolate-homocysteine methyltransferase use betaine and 5-methyltetrahydrofolate, respectively, to regenerate Met from homocysteine. 5-methyltetrahydrofolate 73-97 betaine--homocysteine S-methyltransferase Bos taurus 63-67 29265900-6 2018 L-methyl-folate increases peripheral sensitivity to insulin, maintaining folatemia stable, and thus restoring normal homocysteine levels. 5-methyltetrahydrofolate 0-15 insulin Homo sapiens 52-59 30391174-11 2019 The enzymes encoded by betaine-homocysteine methyltransferase (BHMT) and 5-methyltetrahydrofolate-homocysteine methyltransferase use betaine and 5-methyltetrahydrofolate, respectively, to regenerate Met from homocysteine. 5-methyltetrahydrofolate 73-97 betaine--homocysteine S-methyltransferase Bos taurus 23-61 30269276-10 2018 There was a negative correlation between 5-MTHF concentration in plasma of untreated patients and expression of GGH and SLC46A1/PCFT in tumour. 5-methyltetrahydrofolate 41-47 gamma-glutamyl hydrolase Homo sapiens 112-115 30269276-10 2018 There was a negative correlation between 5-MTHF concentration in plasma of untreated patients and expression of GGH and SLC46A1/PCFT in tumour. 5-methyltetrahydrofolate 41-47 solute carrier family 46 member 1 Homo sapiens 120-127 30269276-10 2018 There was a negative correlation between 5-MTHF concentration in plasma of untreated patients and expression of GGH and SLC46A1/PCFT in tumour. 5-methyltetrahydrofolate 41-47 solute carrier family 46 member 1 Homo sapiens 128-132 29882091-15 2018 A physiological dose of 5-MTHF (800 mug) bypasses the MTHFR block and is suggested to be an effective treatment for these couples. 5-methyltetrahydrofolate 24-30 methylenetetrahydrofolate reductase Homo sapiens 54-59 30228213-11 2018 5-Methyltetrahydrofolate, the main form of folate found in blood, is essential for the vitamin B12-dependent methionine synthase mediated remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 0-24 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 87-128 29860438-2 2018 Here, we show that a MITE transposon insertion caused down-regulation of MTHFR, with an accompanying decrease in 5-methyl-tetrahydrofolate and an increase in 5, 10-methylene-tetrahydrofolate and tetrahydrofolate in the bm2 mutant. 5-methyltetrahydrofolate 113-138 methylenetetrahydrofolate reductase 1 Zea mays 73-78 29891918-2 2018 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection between these cycles, generating 5-methyltetrahydrofolate for initiation of the methionine cycle, and undergoing allosteric inhibition by its end product SAM. 5-methyltetrahydrofolate 121-145 methylenetetrahydrofolate reductase Homo sapiens 0-40 29891918-2 2018 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a key regulatory connection between these cycles, generating 5-methyltetrahydrofolate for initiation of the methionine cycle, and undergoing allosteric inhibition by its end product SAM. 5-methyltetrahydrofolate 121-145 methylenetetrahydrofolate reductase Homo sapiens 42-47 29265900-12 2018 In conclusion, we can state that a good option for the treatment of PCOS is the combined administration of myo-inositol + gymnemic acid + l-methyl-folate, especially for overweight/obese patients with marked insulin resistance and with associated hyperhomocysteinemia. 5-methyltetrahydrofolate 138-153 insulin Homo sapiens 208-215 29412638-7 2018 In vitro, all four 5-MTHF conjugates showed similar binding affinities to FR-alpha (IC50 = 17.7-24.0 nM), whereas folic acid showed a significantly higher binding affinity to the FR-alpha. 5-methyltetrahydrofolate 19-25 rabaptin, RAB GTPase binding effector protein 2 Mus musculus 74-82 29666258-4 2018 Herein, we show that gene trap inactivation of Slc25a32 (Mft) in mice induces NTDs that are folate (5-methyltetrahydrofolate, 5-mTHF) resistant yet are preventable by formate supplementation. 5-methyltetrahydrofolate 100-124 solute carrier family 25, member 32 Mus musculus 47-55 29666258-4 2018 Herein, we show that gene trap inactivation of Slc25a32 (Mft) in mice induces NTDs that are folate (5-methyltetrahydrofolate, 5-mTHF) resistant yet are preventable by formate supplementation. 5-methyltetrahydrofolate 126-132 solute carrier family 25, member 32 Mus musculus 47-55 29412638-7 2018 In vitro, all four 5-MTHF conjugates showed similar binding affinities to FR-alpha (IC50 = 17.7-24.0 nM), whereas folic acid showed a significantly higher binding affinity to the FR-alpha. 5-methyltetrahydrofolate 19-25 rabaptin, RAB GTPase binding effector protein 2 Mus musculus 179-187 29545912-1 2018 5,10-Methylenetrahydrofolate reductase (MTHFR), a key enzyme for folate metabolism, catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is located at the end of the short arm (1p36.3). 5-methyltetrahydrofolate 159-183 methylenetetrahydrofolate reductase Homo sapiens 0-38 29737822-1 2018 BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is the main form of folate used in the body. 5-methyltetrahydrofolate 128-152 methylenetetrahydrofolate reductase Homo sapiens 27-62 29737822-1 2018 BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is the main form of folate used in the body. 5-methyltetrahydrofolate 128-152 methylenetetrahydrofolate reductase Homo sapiens 64-69 29545912-1 2018 5,10-Methylenetrahydrofolate reductase (MTHFR), a key enzyme for folate metabolism, catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is located at the end of the short arm (1p36.3). 5-methyltetrahydrofolate 159-183 methylenetetrahydrofolate reductase Homo sapiens 40-45 28025401-0 2017 Letter re: CSF concentrations of 5-methyltetrahydrofolate in a cohort of young children with autism. 5-methyltetrahydrofolate 33-57 colony stimulating factor 2 Homo sapiens 11-14 27774577-2 2017 Folate is a methyl donor during DNA methylation, as it provides substrate for methylenetetrahydrofolate reductase (MTHFR) to convert 5,10-MTHF to 5-MTHF and subsequently metabolizes it to methionine. 5-methyltetrahydrofolate 146-152 methylenetetrahydrofolate reductase Homo sapiens 78-113 27774577-2 2017 Folate is a methyl donor during DNA methylation, as it provides substrate for methylenetetrahydrofolate reductase (MTHFR) to convert 5,10-MTHF to 5-MTHF and subsequently metabolizes it to methionine. 5-methyltetrahydrofolate 146-152 methylenetetrahydrofolate reductase Homo sapiens 115-120 28623948-14 2017 CSF SAH and 5-MTHF were associated with CSF tau and p-tau181. 5-methyltetrahydrofolate 12-18 microtubule associated protein tau Homo sapiens 44-47 28649192-6 2017 Our results show that the Ts65Dn mouse model of DS was significantly more vulnerable to CFD in terms of plasma homocysteine and N5-methyltetrahydrofolate (5-MTHF) levels. 5-methyltetrahydrofolate 128-153 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 26-32 28649192-6 2017 Our results show that the Ts65Dn mouse model of DS was significantly more vulnerable to CFD in terms of plasma homocysteine and N5-methyltetrahydrofolate (5-MTHF) levels. 5-methyltetrahydrofolate 155-161 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 26-32 27743887-6 2017 A diagnosis of cerebral folate deficiency was confirmed by a homozygous c.466T>G (p.W156G) mutation in FOLR1, coupled with extremely low cerebrospinal fluid levels of 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 170-194 folate receptor alpha Homo sapiens 106-111 29074162-6 2017 In parallel, we have conducted a basic theoretical analysis of the reaction pathway of methionine synthase to assess whether the enzyme cobalamin-independent l-methionine synthase (EC 2.1.1.14)-that catalyzes the synthesis of l-methionine from 5-methyl-tetrahydrofolate and homocysteine-plays a role in causing this depletion. 5-methyltetrahydrofolate 244-269 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 87-106 29074162-6 2017 In parallel, we have conducted a basic theoretical analysis of the reaction pathway of methionine synthase to assess whether the enzyme cobalamin-independent l-methionine synthase (EC 2.1.1.14)-that catalyzes the synthesis of l-methionine from 5-methyl-tetrahydrofolate and homocysteine-plays a role in causing this depletion. 5-methyltetrahydrofolate 244-269 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 160-179 28842818-8 2017 After DNA structure analysis, especially SDI, treatment with 5-methyl tetrahydrofolate (MTHF), the metabolite downstream from the action of MTHFR, should be recommended as a therapeutic approach. 5-methyltetrahydrofolate 61-86 methylenetetrahydrofolate reductase Homo sapiens 140-145 28842818-8 2017 After DNA structure analysis, especially SDI, treatment with 5-methyl tetrahydrofolate (MTHF), the metabolite downstream from the action of MTHFR, should be recommended as a therapeutic approach. 5-methyltetrahydrofolate 88-92 methylenetetrahydrofolate reductase Homo sapiens 140-145 27860207-8 2017 Statistically significant interactions between GSTM1 (where GST is glutathione S-transferase) deletion polymorphism and MD on flavin mononucleotide and on 5-methyltetrahydrofolate (5-MTHF) concentrations were observed. 5-methyltetrahydrofolate 155-179 glutathione S-transferase mu 1 Homo sapiens 47-52 27860207-8 2017 Statistically significant interactions between GSTM1 (where GST is glutathione S-transferase) deletion polymorphism and MD on flavin mononucleotide and on 5-methyltetrahydrofolate (5-MTHF) concentrations were observed. 5-methyltetrahydrofolate 181-187 glutathione S-transferase mu 1 Homo sapiens 47-52 27860207-9 2017 The MTHFR rs1801133 interacted significantly with MD on 5-MTHF concentration. 5-methyltetrahydrofolate 56-62 methylenetetrahydrofolate reductase Homo sapiens 4-9 27860207-10 2017 CONCLUSION: Serum levels of flavin mononucleotide and 5-MTHF were shown to be influenced by interactions between GSTM1 deletion or MTHFR (rs1801133) polymorphisms and a dietary pattern, characteristic of MD. 5-methyltetrahydrofolate 54-60 glutathione S-transferase mu 1 Homo sapiens 113-118 27860207-10 2017 CONCLUSION: Serum levels of flavin mononucleotide and 5-MTHF were shown to be influenced by interactions between GSTM1 deletion or MTHFR (rs1801133) polymorphisms and a dietary pattern, characteristic of MD. 5-methyltetrahydrofolate 54-60 methylenetetrahydrofolate reductase Homo sapiens 131-136 27743313-1 2017 5,10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the NADPH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as the cofactor. 5-methyltetrahydrofolate 126-150 methylenetetrahydrofolate reductase Homo sapiens 0-40 27743313-1 2017 5,10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the NADPH-dependent reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as the cofactor. 5-methyltetrahydrofolate 126-150 methylenetetrahydrofolate reductase Homo sapiens 42-47 28025402-0 2017 Author response: CSF concentrations of 5-methyltetrahydrofolate in a cohort of young children with autism. 5-methyltetrahydrofolate 39-63 colony stimulating factor 2 Homo sapiens 17-20 27523499-9 2017 Cerebral folate deficiency (N=12) was most common, with normal serum folate levels and low CSF 5-methyltetrahydrofolate (5-MTHF) levels. 5-methyltetrahydrofolate 95-119 colony stimulating factor 2 Homo sapiens 91-94 27523499-10 2017 All patients with cerebral folate deficiency, including one with low CSF levels of 5-MTHF and tetrahydrobiopterin intermediates, showed improvement in depression symptom inventories after treatment with folinic acid; the patient with low tetrahydrobiopterin also received sapropterin. 5-methyltetrahydrofolate 83-89 colony stimulating factor 2 Homo sapiens 69-72 27845713-4 2016 Previous research has shown that 5-methyltetrahydrofolate, the product of the reaction catalysed by MTHFR, appears to be a positive allosteric modulator of endothelial nitric oxide synthase (eNOS) and may thus increase the production of nitric oxide, a potent vasodilator. 5-methyltetrahydrofolate 33-57 methylenetetrahydrofolate reductase Homo sapiens 100-105 27845713-4 2016 Previous research has shown that 5-methyltetrahydrofolate, the product of the reaction catalysed by MTHFR, appears to be a positive allosteric modulator of endothelial nitric oxide synthase (eNOS) and may thus increase the production of nitric oxide, a potent vasodilator. 5-methyltetrahydrofolate 33-57 nitric oxide synthase 3 Homo sapiens 156-189 27760199-6 2016 Since boosting the bactericidal activity of sulfonamides through methylfolate trap induction can be achieved in Gram-negative bacteria and mycobacteria, it represents a novel strategy to render these pathogens more susceptible to existing sulfonamides. 5-methyltetrahydrofolate 65-77 TRAP Homo sapiens 78-82 27068282-5 2016 Folate receptor alpha (FRalpha) autoimmunity with low CSF N(5)-methyl-tetrahydrofolate (MTHF) underlies most CFD syndromes, whereas FRalpha gene abnormalities and mitochondrial gene defects are rarely found. 5-methyltetrahydrofolate 58-86 folate receptor alpha Homo sapiens 0-21 27294849-5 2016 We show that at embryonic (E) stage E18 and E20, FDH-positive cells and/or vesicles derived from the cortex can bind methyl-folate similarly to folate receptor alpha, the main folate transporter. 5-methyltetrahydrofolate 117-130 aldehyde dehydrogenase 1 family, member L1 Mus musculus 49-52 27294849-11 2016 We show that FDH binds and transports methylfolate in the brain. 5-methyltetrahydrofolate 38-50 aldehyde dehydrogenase 1 family, member L1 Rattus norvegicus 13-16 27363740-2 2016 METHODS: CSF 5MTHF was determined by high-performance liquid chromatography with fluorescent detection in pediatric patients including one with FOLR1 gene mutation and one with methylenetetrahydrofolate reductase (MTHFR) deficiency. 5-methyltetrahydrofolate 13-18 folate receptor alpha Homo sapiens 144-149 27363740-2 2016 METHODS: CSF 5MTHF was determined by high-performance liquid chromatography with fluorescent detection in pediatric patients including one with FOLR1 gene mutation and one with methylenetetrahydrofolate reductase (MTHFR) deficiency. 5-methyltetrahydrofolate 13-18 methylenetetrahydrofolate reductase Homo sapiens 177-212 27363740-2 2016 METHODS: CSF 5MTHF was determined by high-performance liquid chromatography with fluorescent detection in pediatric patients including one with FOLR1 gene mutation and one with methylenetetrahydrofolate reductase (MTHFR) deficiency. 5-methyltetrahydrofolate 13-18 methylenetetrahydrofolate reductase Homo sapiens 214-219 27363740-8 2016 The patient with MTHFR deficiency had extremely low 5MTHF and moderately low total folate; these values were not associated and showed no significant change after folic acid supplementation. 5-methyltetrahydrofolate 52-57 methylenetetrahydrofolate reductase Homo sapiens 17-22 27520898-0 2016 Effectiveness of add-on l-methylfolate therapy in a complex psychiatric illness with MTHFR C677 T genetic polymorphism. 5-methyltetrahydrofolate 24-38 methylenetetrahydrofolate reductase Homo sapiens 85-90 27520898-4 2016 Here we have tried to show how the l-methylfolate in conjunction with the conventional psychotropic drugs can be useful in a state of such complex psychiatric phenomenon and comorbid diagnosis with genetic polymorphism of MTHFR C677 T mutation. 5-methyltetrahydrofolate 35-49 methylenetetrahydrofolate reductase Homo sapiens 222-227 27068282-5 2016 Folate receptor alpha (FRalpha) autoimmunity with low CSF N(5)-methyl-tetrahydrofolate (MTHF) underlies most CFD syndromes, whereas FRalpha gene abnormalities and mitochondrial gene defects are rarely found. 5-methyltetrahydrofolate 58-86 FOS like 1, AP-1 transcription factor subunit Homo sapiens 23-30 27068282-5 2016 Folate receptor alpha (FRalpha) autoimmunity with low CSF N(5)-methyl-tetrahydrofolate (MTHF) underlies most CFD syndromes, whereas FRalpha gene abnormalities and mitochondrial gene defects are rarely found. 5-methyltetrahydrofolate 88-92 folate receptor alpha Homo sapiens 0-21 27068282-5 2016 Folate receptor alpha (FRalpha) autoimmunity with low CSF N(5)-methyl-tetrahydrofolate (MTHF) underlies most CFD syndromes, whereas FRalpha gene abnormalities and mitochondrial gene defects are rarely found. 5-methyltetrahydrofolate 88-92 FOS like 1, AP-1 transcription factor subunit Homo sapiens 23-30 27068282-7 2016 Infantile CFD syndrome and autism with neurological deficits tend to be characterized by elevated FRalpha antibody titers and low CSF MTHF. 5-methyltetrahydrofolate 134-138 colony stimulating factor 2 Homo sapiens 130-133 27178705-0 2016 CSF concentrations of 5-methyltetrahydrofolate in a cohort of young children with autism. 5-methyltetrahydrofolate 22-46 colony stimulating factor 2 Homo sapiens 0-3 27178705-1 2016 OBJECTIVE: To examine the association between cerebral folate deficiency and autism, this study examined CSF 5-methyltetrahydrofolate (5-MTHF) concentrations in a group of young children with autism, investigated the natural variation in CSF 5-MTHF over time, and assessed the relationship between CSF 5-MTHF and symptoms. 5-methyltetrahydrofolate 109-133 colony stimulating factor 2 Homo sapiens 105-108 27178705-5 2016 A moderate correlation with a very wide confidence interval (CI) was observed between time 1 and time 2 CSF 5-MTHF measurements (Pearson r[p] = 0.38 [0.04]; 95% CI 0.02-0.64). 5-methyltetrahydrofolate 108-114 colony stimulating factor 2 Homo sapiens 104-107 27178705-7 2016 CONCLUSIONS: CSF 5-MTHF levels vary significantly over time in an unpredictable fashion and do not show a significant relationship to typical clinical features of autism. 5-methyltetrahydrofolate 17-23 colony stimulating factor 2 Homo sapiens 13-16 27178705-8 2016 Reduced CSF 5-MTHF levels are a nonspecific finding in autism. 5-methyltetrahydrofolate 12-18 colony stimulating factor 2 Homo sapiens 8-11 26813460-3 2016 MTHFR catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and plays a vital role in Hcy metabolism. 5-methyltetrahydrofolate 81-105 methylenetetrahydrofolate reductase Homo sapiens 0-5 27013776-7 2016 Furthermore, supplementation of 5-methyltetrahydrofolate to the dihydrofolate reductase knockdown cells could weaken the inhibitory effect of dihydrofolate reductase knockdown on cell proliferation, simultaneously, inducing the expression of p53 and p21(waf/cip1) falling back moderately. 5-methyltetrahydrofolate 32-56 dihydrofolate reductase Homo sapiens 64-87 27013776-7 2016 Furthermore, supplementation of 5-methyltetrahydrofolate to the dihydrofolate reductase knockdown cells could weaken the inhibitory effect of dihydrofolate reductase knockdown on cell proliferation, simultaneously, inducing the expression of p53 and p21(waf/cip1) falling back moderately. 5-methyltetrahydrofolate 32-56 dihydrofolate reductase Homo sapiens 142-165 27013776-7 2016 Furthermore, supplementation of 5-methyltetrahydrofolate to the dihydrofolate reductase knockdown cells could weaken the inhibitory effect of dihydrofolate reductase knockdown on cell proliferation, simultaneously, inducing the expression of p53 and p21(waf/cip1) falling back moderately. 5-methyltetrahydrofolate 32-56 tumor protein p53 Homo sapiens 242-245 27013776-7 2016 Furthermore, supplementation of 5-methyltetrahydrofolate to the dihydrofolate reductase knockdown cells could weaken the inhibitory effect of dihydrofolate reductase knockdown on cell proliferation, simultaneously, inducing the expression of p53 and p21(waf/cip1) falling back moderately. 5-methyltetrahydrofolate 32-56 cyclin dependent kinase inhibitor 1A Homo sapiens 250-253 27013776-7 2016 Furthermore, supplementation of 5-methyltetrahydrofolate to the dihydrofolate reductase knockdown cells could weaken the inhibitory effect of dihydrofolate reductase knockdown on cell proliferation, simultaneously, inducing the expression of p53 and p21(waf/cip1) falling back moderately. 5-methyltetrahydrofolate 32-56 cyclin dependent kinase inhibitor 1A Homo sapiens 258-262 26898294-7 2016 Only treatment with oral 5-MTHF given as calcium mefolinate at doses of 15-60 mg/kg/day resulted in an increase in CSF 5-MTHF. 5-methyltetrahydrofolate 25-31 colony stimulating factor 2 Homo sapiens 115-118 26898294-7 2016 Only treatment with oral 5-MTHF given as calcium mefolinate at doses of 15-60 mg/kg/day resulted in an increase in CSF 5-MTHF. 5-methyltetrahydrofolate 41-59 colony stimulating factor 2 Homo sapiens 115-118 26898294-3 2016 Patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency cannot make 5-MTHF and have extremely low levels in the CSF. 5-methyltetrahydrofolate 88-94 methylenetetrahydrofolate reductase Homo sapiens 21-56 26898294-3 2016 Patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency cannot make 5-MTHF and have extremely low levels in the CSF. 5-methyltetrahydrofolate 88-94 methylenetetrahydrofolate reductase Homo sapiens 58-63 26898294-7 2016 Only treatment with oral 5-MTHF given as calcium mefolinate at doses of 15-60 mg/kg/day resulted in an increase in CSF 5-MTHF. 5-methyltetrahydrofolate 119-125 colony stimulating factor 2 Homo sapiens 115-118 26898294-6 2016 We report three patients with severe MTHFR deficiency (enzyme activity <=1% of controls) who had undetectable levels of CSF 5-MTHF at diagnosis and while on treatment with either folic acid or calcium folinate. 5-methyltetrahydrofolate 127-133 methylenetetrahydrofolate reductase Homo sapiens 37-42 26095803-1 2015 Methylenetetrahydrofolate reductase (MTHFR) reduces 5",10"-methylenetetrahydrofolate to 5"-methyltetrahydrofolate, and is involved in remethylation of homocysteine to methionine, two important reactions involved in folate metabolism and methylation pathways. 5-methyltetrahydrofolate 88-113 methylenetetrahydrofolate reductase Homo sapiens 37-42 26400185-9 2015 Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells. 5-methyltetrahydrofolate 34-58 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 132-136 26400185-9 2015 Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells. 5-methyltetrahydrofolate 34-58 serine/threonine kinase 11 Homo sapiens 141-145 26095803-1 2015 Methylenetetrahydrofolate reductase (MTHFR) reduces 5",10"-methylenetetrahydrofolate to 5"-methyltetrahydrofolate, and is involved in remethylation of homocysteine to methionine, two important reactions involved in folate metabolism and methylation pathways. 5-methyltetrahydrofolate 88-113 methylenetetrahydrofolate reductase Homo sapiens 0-35 26467983-7 2015 RESULTS: We study the allosteric binding of 5-methyltetrahydrofolate (5 mTHF) to glycine-N-methyltransferase (GNMT) and explain why data in the literature implies that when one molecule binds, GNMT retains half its activity. 5-methyltetrahydrofolate 44-68 glycine N-methyltransferase Homo sapiens 81-108 26467983-7 2015 RESULTS: We study the allosteric binding of 5-methyltetrahydrofolate (5 mTHF) to glycine-N-methyltransferase (GNMT) and explain why data in the literature implies that when one molecule binds, GNMT retains half its activity. 5-methyltetrahydrofolate 44-68 glycine N-methyltransferase Homo sapiens 110-114 26467983-7 2015 RESULTS: We study the allosteric binding of 5-methyltetrahydrofolate (5 mTHF) to glycine-N-methyltransferase (GNMT) and explain why data in the literature implies that when one molecule binds, GNMT retains half its activity. 5-methyltetrahydrofolate 44-68 glycine N-methyltransferase Homo sapiens 193-197 26467983-7 2015 RESULTS: We study the allosteric binding of 5-methyltetrahydrofolate (5 mTHF) to glycine-N-methyltransferase (GNMT) and explain why data in the literature implies that when one molecule binds, GNMT retains half its activity. 5-methyltetrahydrofolate 70-76 glycine N-methyltransferase Homo sapiens 81-108 26467983-7 2015 RESULTS: We study the allosteric binding of 5-methyltetrahydrofolate (5 mTHF) to glycine-N-methyltransferase (GNMT) and explain why data in the literature implies that when one molecule binds, GNMT retains half its activity. 5-methyltetrahydrofolate 70-76 glycine N-methyltransferase Homo sapiens 110-114 26467983-7 2015 RESULTS: We study the allosteric binding of 5-methyltetrahydrofolate (5 mTHF) to glycine-N-methyltransferase (GNMT) and explain why data in the literature implies that when one molecule binds, GNMT retains half its activity. 5-methyltetrahydrofolate 70-76 glycine N-methyltransferase Homo sapiens 193-197 25733650-10 2015 5-Methyltetrahydrofolate, SAM, and SAM/S-adenosylhomocysteine ratios were lower in FASD and Mthfr(+/-) livers. 5-methyltetrahydrofolate 0-24 methylenetetrahydrofolate reductase Mus musculus 92-97 25802929-4 2015 Our aim was to demonstrate that high concentrations of FA or its reduced form, 5-methyltetrahydrofolic acid (5-MTHF), increase colorectal carcinoma HT29 cell proliferation through an increase of Notch1 activation and to prove if the inhibition of Notch1 activation by gamma secretase inhibitor, reduce the effect of folic acid. 5-methyltetrahydrofolate 79-107 notch receptor 1 Homo sapiens 195-201 26673393-9 2015 Natural 5-methyltetrahydrofolate intake is interesting: Wildtype A1298C-MTHFR, heterozygote C677T-MTHFR, wildtype A2756G-MS and recessive A66G-MSR individuals all show a significant reciprocal association with homocysteine. 5-methyltetrahydrofolate 8-32 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Homo sapiens 143-146 26028103-1 2015 BACKGROUND: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. 5-methyltetrahydrofolate 130-142 folate hydrolase 1 Homo sapiens 38-67 26028103-1 2015 BACKGROUND: The C1561T variant of the glutamate carboxypeptidase II (GCPII) gene is critical for natural methylfolylpolyglutamte (methylfolate) absorption, and has been associated with perturbations in folate metabolism and disease susceptibility. 5-methyltetrahydrofolate 130-142 folate hydrolase 1 Homo sapiens 69-74 26006721-0 2015 CSF 5-Methyltetrahydrofolate Serial Monitoring to Guide Treatment of Congenital Folate Malabsorption Due to Proton-Coupled Folate Transporter (PCFT) Deficiency. 5-methyltetrahydrofolate 4-28 solute carrier family 46 member 1 Homo sapiens 108-141 25802929-4 2015 Our aim was to demonstrate that high concentrations of FA or its reduced form, 5-methyltetrahydrofolic acid (5-MTHF), increase colorectal carcinoma HT29 cell proliferation through an increase of Notch1 activation and to prove if the inhibition of Notch1 activation by gamma secretase inhibitor, reduce the effect of folic acid. 5-methyltetrahydrofolate 79-107 notch receptor 1 Homo sapiens 247-253 25802929-4 2015 Our aim was to demonstrate that high concentrations of FA or its reduced form, 5-methyltetrahydrofolic acid (5-MTHF), increase colorectal carcinoma HT29 cell proliferation through an increase of Notch1 activation and to prove if the inhibition of Notch1 activation by gamma secretase inhibitor, reduce the effect of folic acid. 5-methyltetrahydrofolate 109-115 notch receptor 1 Homo sapiens 195-201 25802929-4 2015 Our aim was to demonstrate that high concentrations of FA or its reduced form, 5-methyltetrahydrofolic acid (5-MTHF), increase colorectal carcinoma HT29 cell proliferation through an increase of Notch1 activation and to prove if the inhibition of Notch1 activation by gamma secretase inhibitor, reduce the effect of folic acid. 5-methyltetrahydrofolate 109-115 notch receptor 1 Homo sapiens 247-253 25802929-8 2015 This effect on proliferation was partially reversible when we blocked Notch1 activation with the inhibitor of gamma-secretase (P < 0.05).These data suggest that high concentration of FA and 5-MTHF induce HT29 cell proliferation activating Notch1 pathway. 5-methyltetrahydrofolate 193-199 notch receptor 1 Homo sapiens 70-76 25802929-8 2015 This effect on proliferation was partially reversible when we blocked Notch1 activation with the inhibitor of gamma-secretase (P < 0.05).These data suggest that high concentration of FA and 5-MTHF induce HT29 cell proliferation activating Notch1 pathway. 5-methyltetrahydrofolate 193-199 notch receptor 1 Homo sapiens 242-248 25456743-1 2014 BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. 5-methyltetrahydrofolate 101-128 folate receptor alpha Homo sapiens 36-57 25456743-1 2014 BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. 5-methyltetrahydrofolate 101-128 FOS like 1, AP-1 transcription factor subunit Homo sapiens 59-66 25456743-1 2014 BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. 5-methyltetrahydrofolate 130-134 folate receptor alpha Homo sapiens 36-57 25456743-1 2014 BACKGROUND: Auto-antibodies against folate receptor alpha (FRalpha) at the choroid plexus that block N(5)-methyltetrahydrofolate (MTHF) transfer to the brain were identified in catatonic schizophrenia. 5-methyltetrahydrofolate 130-134 FOS like 1, AP-1 transcription factor subunit Homo sapiens 59-66 25265565-1 2014 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 182-206 methylenetetrahydrofolate reductase Homo sapiens 12-47 25265565-1 2014 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 182-206 methylenetetrahydrofolate reductase Homo sapiens 49-54 24944062-8 2014 Therefore, large amounts of unmodified folic acid in the portal vein are probably attributable to an extremely limited mucosal cell dihydrofolate reductase (DHFR) capacity that is necessary to produce tetrahydrofolic acid before sequential methylation to 5-MTHF. 5-methyltetrahydrofolate 255-261 dihydrofolate reductase Homo sapiens 132-155 24944062-8 2014 Therefore, large amounts of unmodified folic acid in the portal vein are probably attributable to an extremely limited mucosal cell dihydrofolate reductase (DHFR) capacity that is necessary to produce tetrahydrofolic acid before sequential methylation to 5-MTHF. 5-methyltetrahydrofolate 255-261 dihydrofolate reductase Homo sapiens 157-161 23922098-2 2014 GNMT binds to methylfolate but is also inhibited by it; how such interactions affect human carcinogenesis is unclear. 5-methyltetrahydrofolate 14-26 glycine N-methyltransferase Homo sapiens 0-4 24878879-6 2014 Serum samples of NTD-affected pregnancies and controls from a NTD high-risk area in China were analyzed by this method, the NTD serum samples showed lower concentrations of 5-MeTHF (P<0.05) and 5-FoTHF (P<0.05), and higher concentrations of Hcy (P<0.05) and SAH (P<0.05) compared with serum samples from controls, consistent with a previous study. 5-methyltetrahydrofolate 173-180 fuzzy planar cell polarity protein Homo sapiens 17-20 24769206-1 2014 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the folate cycle, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 140-164 methylenetetrahydrofolate reductase Homo sapiens 0-35 24769206-1 2014 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the folate cycle, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 140-164 methylenetetrahydrofolate reductase Homo sapiens 37-42 24380661-2 2014 MTHFR is a critical enzyme in folate metabolism that catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, thus playing a vital role in DNA synthesis and DNA methylation. 5-methyltetrahydrofolate 128-152 methylenetetrahydrofolate reductase Homo sapiens 0-5 24268539-1 2014 Methionine synthase catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine, producing methionine and tetrahydrofolate. 5-methyltetrahydrofolate 66-90 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 0-19 24268539-2 2014 Benzimidazole and deazatetrahydrofolates derivatives have been shown to inhibit methionine synthase by competing with the substrate 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 132-156 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 80-99 24385849-2 2013 The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the rate-limiting step of the cycle involving the methyl donor S-adenosyl-L-methionine (SAM). 5-methyltetrahydrofolate 116-140 methylenetetrahydrofolate reductase Homo sapiens 11-46 24385849-2 2013 The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the rate-limiting step of the cycle involving the methyl donor S-adenosyl-L-methionine (SAM). 5-methyltetrahydrofolate 116-140 methylenetetrahydrofolate reductase Homo sapiens 48-53 24091540-5 2013 Patient 1A with FOLR1 mutations showed extremely low concentration of 5-methyltetrahydrofolate in the cerebrospinal fluid and serum, and Patient 6 with TPP1 mutations demonstrated markedly lowered tripeptidyl peptidase 1 activity in leukocytes. 5-methyltetrahydrofolate 70-94 folate receptor alpha Homo sapiens 16-21 23432920-6 2013 Further studies implied that THH might reduce the aGVHD by increasing IL-10, decreasing IL-4, activating Treg cell, and maintaining a relatively high Foxp3 mRNA level. 5-methyltetrahydrofolate 29-32 interleukin 10 Mus musculus 70-75 23432920-6 2013 Further studies implied that THH might reduce the aGVHD by increasing IL-10, decreasing IL-4, activating Treg cell, and maintaining a relatively high Foxp3 mRNA level. 5-methyltetrahydrofolate 29-32 interleukin 4 Mus musculus 88-92 23432920-6 2013 Further studies implied that THH might reduce the aGVHD by increasing IL-10, decreasing IL-4, activating Treg cell, and maintaining a relatively high Foxp3 mRNA level. 5-methyltetrahydrofolate 29-32 forkhead box P3 Mus musculus 150-155 23432920-7 2013 CONCLUSION: THH decreased the occurrence of mouse aGVHD and prolonged the survival time by increasing the levels of CD(4)(+)/CD(25)(+) T cells, regulating the cytokine secretion and promoting the expression of Foxp3. 5-methyltetrahydrofolate 12-15 forkhead box P3 Mus musculus 210-215 23828504-5 2013 Loss of folate receptor-alpha-expressing cerebrospinal fluid exosomes correlates with severely reduced 5-methyltetrahydrofolate concentration, corroborating the importance of the folate receptor-alpha-mediated folate transport in the cerebrospinal fluid. 5-methyltetrahydrofolate 103-127 folate receptor alpha Homo sapiens 8-29 23874907-1 2013 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles participating in nucleotide synthesis, DNA repair, genome stability, maintenance of methyl pool, and gene regulation. 5-methyltetrahydrofolate 100-125 methylenetetrahydrofolate reductase Homo sapiens 12-47 23874907-1 2013 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) converts 5,10-methylene tetrahydrofolate to 5-methyl tetrahydrofolate and affects the activity of cellular cycles participating in nucleotide synthesis, DNA repair, genome stability, maintenance of methyl pool, and gene regulation. 5-methyltetrahydrofolate 100-125 methylenetetrahydrofolate reductase Homo sapiens 49-54 23122153-3 2013 In this study, a comparison between [6S]-5-methyltetrahydrofolic acid (5-MTHF) and its racemate [6R,S] form was made by TEAC assay at different pHs, FRAP assay, and ORAC assay. 5-methyltetrahydrofolate 71-77 mechanistic target of rapamycin kinase Homo sapiens 149-153 23099812-7 2013 Oxidative stress, which occurs in the course of disease in the ArcAbeta mice, consumes 5-MTHF. 5-methyltetrahydrofolate 87-93 histocompatibility 2, class II antigen A, beta 1 Mus musculus 63-71 24205029-5 2013 Here, we examined the effects of Nat2 deletion in male and female mice on the tissue levels of 5-methyl-tetrahydrofolate and the methionine-S-adenosylmethionine cycle. 5-methyltetrahydrofolate 95-120 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 33-37 24205029-10 2013 Deletion of Nat2 affected liver 5- methyl-tetrahydrofolate in female mice but had little effect on other components of the methionine-S-adenosylmethionine cycle. 5-methyltetrahydrofolate 32-58 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 12-16 23914427-1 2013 BACKGROUND: The enzyme MTHFR catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which serves as a methyl donor in the reaction converting homocysteine to methionine. 5-methyltetrahydrofolate 104-128 methylenetetrahydrofolate reductase Homo sapiens 23-28 23313250-4 2013 The aim of this study was to study in vitro the possible effect of different concentrations of 5-methyltetrahydrofolic acid (5-MTHF) or folic acid on NK cell cytotoxic function, and expression of the stimulatory and inhibitory receptors KIRDL4, KIRDL3, and NKG2D. 5-methyltetrahydrofolate 95-123 killer cell lectin like receptor K1 Homo sapiens 257-262 23313250-4 2013 The aim of this study was to study in vitro the possible effect of different concentrations of 5-methyltetrahydrofolic acid (5-MTHF) or folic acid on NK cell cytotoxic function, and expression of the stimulatory and inhibitory receptors KIRDL4, KIRDL3, and NKG2D. 5-methyltetrahydrofolate 125-131 killer cell lectin like receptor K1 Homo sapiens 257-262 23234354-1 2013 Fortification of foods with L-5-methyltetrahydrofolic acid (L-5-MTHF) is challenging due to low stability to environmental conditions that include exposure to pH, moisture, and temperature. 5-methyltetrahydrofolate 28-58 ribosomal protein L5 Homo sapiens 60-68 23116396-1 2013 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydofolate (CH2-H4folate) to 5-methyltetrahydrofolate (CH3-H4folate). 5-methyltetrahydrofolate 119-143 methylenetetrahydrofolate reductase Homo sapiens 0-35 23116396-1 2013 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydofolate (CH2-H4folate) to 5-methyltetrahydrofolate (CH3-H4folate). 5-methyltetrahydrofolate 119-143 methylenetetrahydrofolate reductase Homo sapiens 37-42 23350208-6 2012 About half of the European population appears to have a gene mutation on the gene coding for the production of methylenetetrahydrofolate reductase, the enzyme that is involved in the formation of 5-methyltetrahydrofolate, which is, in his turn, responsible for the conversion of the toxic homocysteine in methionine. 5-methyltetrahydrofolate 196-220 methylenetetrahydrofolate reductase Homo sapiens 111-146 21644011-1 2012 Methotrexate inhibits the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 74-98 methylenetetrahydrofolate reductase Homo sapiens 102-137 23387078-1 2012 Methionine synthase (MS, EC2.1.1.13), a key enzyme in the folate metabolism area catalyzing methyl transfer from N5-methyltetrahydrofolate to homocysteine to give tetrahydrofolate and methionine, takes a core position in folate cycle, one-carbon-unit transfer and sculpture amino acid pathways. 5-methyltetrahydrofolate 113-138 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 0-19 21644011-1 2012 Methotrexate inhibits the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 74-98 methylenetetrahydrofolate reductase Homo sapiens 139-144 25683392-1 2012 Our aim was to protect l-5-methyltetrahydrofolic acid (L-5-MTHF) from degradation throughout the baking and storage of a fortified white bread using microencapsulation. 5-methyltetrahydrofolate 23-53 ribosomal protein L5 Homo sapiens 55-63 22554803-3 2012 Exposure of HeLa cells to AICAR resulted in augmentation of methotrexate, 5-formyltetrahydrofolate, and 5-methyltetrahydrofolate initial rates and net uptake in cells that express the reduced folate carrier (RFC). 5-methyltetrahydrofolate 104-128 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 26-31 22411217-7 2012 Recent research evidence has suggested that MTHFR variants might be independently linked to CVDs and hypertension, because of the involvement of the MTHFR enzyme product (5-methyl-tetrahydrofolate /5-MTHF) in the regulation of endothelial functions. 5-methyltetrahydrofolate 171-196 methylenetetrahydrofolate reductase Homo sapiens 44-49 26105327-9 2012 The reduced-folate carrier (RFC-1) facilitates the internalization of 5-methyltetrahydrofolate from the blood into peripheral cells. 5-methyltetrahydrofolate 70-94 replication factor C subunit 1 Homo sapiens 28-33 22411217-7 2012 Recent research evidence has suggested that MTHFR variants might be independently linked to CVDs and hypertension, because of the involvement of the MTHFR enzyme product (5-methyl-tetrahydrofolate /5-MTHF) in the regulation of endothelial functions. 5-methyltetrahydrofolate 171-196 methylenetetrahydrofolate reductase Homo sapiens 149-154 22411217-7 2012 Recent research evidence has suggested that MTHFR variants might be independently linked to CVDs and hypertension, because of the involvement of the MTHFR enzyme product (5-methyl-tetrahydrofolate /5-MTHF) in the regulation of endothelial functions. 5-methyltetrahydrofolate 198-204 methylenetetrahydrofolate reductase Homo sapiens 44-49 22411217-7 2012 Recent research evidence has suggested that MTHFR variants might be independently linked to CVDs and hypertension, because of the involvement of the MTHFR enzyme product (5-methyl-tetrahydrofolate /5-MTHF) in the regulation of endothelial functions. 5-methyltetrahydrofolate 198-204 methylenetetrahydrofolate reductase Homo sapiens 149-154 22037183-0 2012 Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 141-165 glycine N-methyltransferase Rattus norvegicus 110-137 22037183-3 2012 GNMT is inhibited by binding two molecules of 5-methyltetrahydrofolate (mono- or polyglutamate forms) per tetramer of the active enzyme. 5-methyltetrahydrofolate 46-70 glycine N-methyltransferase Rattus norvegicus 0-4 22217364-1 2012 BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. 5-methyltetrahydrofolate 129-153 methylenetetrahydrofolate reductase Homo sapiens 16-51 22217364-1 2012 BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) enzyme catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate and methyl donors. 5-methyltetrahydrofolate 129-153 methylenetetrahydrofolate reductase Homo sapiens 53-58 21769670-1 2011 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units for methylation. 5-methyltetrahydrofolate 92-116 methylenetetrahydrofolate reductase Mus musculus 0-35 22057276-4 2011 SHMT1 generates 5,10-methylenetetrahydrofolate for de novo thymidylate biosynthesis, a limiting step in the pathway, but also tightly binds 5-methyltetrahydrofolate in the cytoplasm, a required cofactor for homocysteine remethylation. 5-methyltetrahydrofolate 140-164 serine hydroxymethyltransferase 1 (soluble) Mus musculus 0-5 22116707-3 2012 The cytoplasmatic methionine synthase catalyzes the transfer of a methyl group from N-methyl-tetrahydrofolate to homocysteine to yield methionine and to liberate tetrahydrofolate. 5-methyltetrahydrofolate 84-109 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 18-37 21769670-1 2011 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, synthesizes 5-methyltetrahydrofolate, the main circulatory form of folate which is required for maintaining nontoxic levels of homocysteine and providing one-carbon units for methylation. 5-methyltetrahydrofolate 92-116 methylenetetrahydrofolate reductase Mus musculus 37-42 21968302-6 2011 CONCLUSION: THH may mitigate joint inflammation of CIA model rat through reduction of HIF-1alpha expression. 5-methyltetrahydrofolate 12-15 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 86-96 22108397-3 2011 However, some individuals have a genetic deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene that limits conversion of folic acid to its biologically active form, L-methylfolate. 5-methyltetrahydrofolate 179-193 methylenetetrahydrofolate reductase Homo sapiens 59-95 22108397-3 2011 However, some individuals have a genetic deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene that limits conversion of folic acid to its biologically active form, L-methylfolate. 5-methyltetrahydrofolate 179-193 methylenetetrahydrofolate reductase Homo sapiens 97-102 22108397-13 2011 Additional research is also needed to confirm the benefit of L-methylfolate in specific patient populations (e.g., MTHFR TT genotype). 5-methyltetrahydrofolate 61-75 methylenetetrahydrofolate reductase Homo sapiens 115-120 21674649-2 2011 The metabolism of folic acid and vitamin B12 intersect during the transfer of the methyl group from 5-methyltetrahydrofolate to homocysteine catalyzed by B12-dependent methioine synthase. 5-methyltetrahydrofolate 100-124 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 41-44 21697299-2 2011 Folate deficiency and mutations of methylenetetrahydrofolate reductase (MTHFR) reduce the availability of a major methyl donor, 5-methyltetrahydrofolate, which in turn may lead to compensatory changes in choline metabolism. 5-methyltetrahydrofolate 128-152 methylenetetrahydrofolate reductase Homo sapiens 35-70 21697299-2 2011 Folate deficiency and mutations of methylenetetrahydrofolate reductase (MTHFR) reduce the availability of a major methyl donor, 5-methyltetrahydrofolate, which in turn may lead to compensatory changes in choline metabolism. 5-methyltetrahydrofolate 128-152 methylenetetrahydrofolate reductase Homo sapiens 72-77 21674649-2 2011 The metabolism of folic acid and vitamin B12 intersect during the transfer of the methyl group from 5-methyltetrahydrofolate to homocysteine catalyzed by B12-dependent methioine synthase. 5-methyltetrahydrofolate 100-124 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 154-157 21121936-1 2011 BACKGROUND: Methionine synthase (MS) is a ubiquitous enzyme that requires vitamin B12 (cobalamin) and 5-methyl-tetrahydrofolate for the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 102-127 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 12-31 21555636-10 2011 Severe 5-MTHF depletion (n = 8; range, 0.6-13 nmol/L) was detected in severe MTHF reductase deficiency, Kearns-Sayre syndrome, biotin-responsive striatal necrosis, acute necrotizing encephalitis of Hurst, and FOLR1 defect. 5-methyltetrahydrofolate 7-13 folate receptor alpha Homo sapiens 209-214 21372133-8 2011 Importantly, MTHFS also affected M. smegmatis utilization of monoglutamylated 5-methyltetrahydrofolate exogenously added to the medium. 5-methyltetrahydrofolate 78-102 methenyltetrahydrofolate synthetase Homo sapiens 13-18 21210071-10 2011 Liver folate levels correlated well with GNMT expressions (r = 0.53, P = 0.002); and methionine synthase expression was reduced significantly in GNMT(ko), demonstrating impaired methylfolate-dependent metabolism by GNMT deletion. 5-methyltetrahydrofolate 178-190 glycine N-methyltransferase Homo sapiens 145-149 21210071-10 2011 Liver folate levels correlated well with GNMT expressions (r = 0.53, P = 0.002); and methionine synthase expression was reduced significantly in GNMT(ko), demonstrating impaired methylfolate-dependent metabolism by GNMT deletion. 5-methyltetrahydrofolate 178-190 glycine N-methyltransferase Homo sapiens 145-149 21210071-11 2011 In conclusion, we demonstrated novel findings that restoring GNMT assists methylfolate-dependent reactions and ameliorates the consequences of folate depletion. 5-methyltetrahydrofolate 74-86 glycine N-methyltransferase Homo sapiens 61-65 21305354-8 2011 A positive correlation was seen between the CSF PLP and 5-methyl-tetrahydrofolate (5-MTHF) and tetrahydrobiopterin (BH(4)) concentrations. 5-methyltetrahydrofolate 56-81 pyridoxal phosphatase Homo sapiens 48-51 21305354-8 2011 A positive correlation was seen between the CSF PLP and 5-methyl-tetrahydrofolate (5-MTHF) and tetrahydrobiopterin (BH(4)) concentrations. 5-methyltetrahydrofolate 83-89 pyridoxal phosphatase Homo sapiens 48-51 20857335-10 2010 Mutation screening in the FOLR1 gene is advisable in children with profound 5MTHF deficiency and decreased CSF/serum folate ratio. 5-methyltetrahydrofolate 76-81 folate receptor alpha Homo sapiens 26-31 21058067-7 2010 Duodenal and caecal PCFT mRNA was not affected by dietary treatments; however, jejunal PCFT mRNA was significantly reduced in hens fed the 5-MTHF diet versus the basal diet. 5-methyltetrahydrofolate 139-145 solute carrier family 46 member 1 Gallus gallus 87-91 21438406-5 2010 RESULT: THH not only significantly decreased urine protein, reduced serum urea nitrogen, but also decreased the releases of inflammatory mediators (such as IL-1, IL-6 and TNF-alpha). 5-methyltetrahydrofolate 8-11 interleukin 6 Rattus norvegicus 162-166 21438406-5 2010 RESULT: THH not only significantly decreased urine protein, reduced serum urea nitrogen, but also decreased the releases of inflammatory mediators (such as IL-1, IL-6 and TNF-alpha). 5-methyltetrahydrofolate 8-11 tumor necrosis factor Rattus norvegicus 171-180 20808328-1 2010 BACKGROUND/OBJECTIVES: Methionine synthase catalyzes the conversion of 5-methyltetrahydrofolate to tetrahydrofolate and homocysteine (Hcy) to methionine using vitamin B(12) as a cofactor. 5-methyltetrahydrofolate 71-95 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 23-42 21058067-10 2010 The expression of jejunal PCFT mRNA was down-regulated by dietary 5-MTHF supplementation. 5-methyltetrahydrofolate 66-72 solute carrier family 46 member 1 Gallus gallus 26-30 20518745-9 2010 5-Methyltetrahydrofolate and 5-formyltetrahydrofolate with one and five glutamate residues inhibited AtSHMT3-catalysed hydroxymethyl group transfer from serine to H4PteGlu6, with the pentaglutamylated inhibitors being more effective. 5-methyltetrahydrofolate 0-24 serine hydroxymethyltransferase 3 Arabidopsis thaliana 101-108 20619709-0 2010 Effect of antiepileptic drugs and reactive oxygen species on folate receptor 1 (FOLR1)-dependent 5-methyltetrahydrofolate transport. 5-methyltetrahydrofolate 97-121 folate receptor alpha Homo sapiens 61-78 20619709-0 2010 Effect of antiepileptic drugs and reactive oxygen species on folate receptor 1 (FOLR1)-dependent 5-methyltetrahydrofolate transport. 5-methyltetrahydrofolate 97-121 folate receptor alpha Homo sapiens 80-85 20619709-3 2010 Using KB-cell cultures, highly expressing the folate receptor 1 (FOLR1), the effect of antiepileptic drugs (AEDs) and reactive oxygen species (ROS) on the FOLR1 dependent 5-methyltetrahydrofolate (MTHF) uptake was studied. 5-methyltetrahydrofolate 171-195 folate receptor alpha Homo sapiens 155-160 20619709-3 2010 Using KB-cell cultures, highly expressing the folate receptor 1 (FOLR1), the effect of antiepileptic drugs (AEDs) and reactive oxygen species (ROS) on the FOLR1 dependent 5-methyltetrahydrofolate (MTHF) uptake was studied. 5-methyltetrahydrofolate 197-201 folate receptor alpha Homo sapiens 155-160 20619709-5 2010 At physiological MTHF concentrations the high-affinity FOLR1 represents the predominant mechanism for cellular incorporation, while at high MTHF concentrations other transport mechanisms participate in folate uptake. 5-methyltetrahydrofolate 17-21 folate receptor alpha Homo sapiens 55-60 20619709-8 2010 By specific elimination and downregulation of FOLR1 using phosphatidyl-inositol-specific phospholipase C (PIPLC) and siRNA silencing, it was shown that ROS not only inhibited FOLR1 mediated MTHF uptake but also affected all other mechanisms of membrane-mediated MTHF uptake. 5-methyltetrahydrofolate 190-194 folate receptor alpha Homo sapiens 46-51 20619709-8 2010 By specific elimination and downregulation of FOLR1 using phosphatidyl-inositol-specific phospholipase C (PIPLC) and siRNA silencing, it was shown that ROS not only inhibited FOLR1 mediated MTHF uptake but also affected all other mechanisms of membrane-mediated MTHF uptake. 5-methyltetrahydrofolate 262-266 folate receptor alpha Homo sapiens 46-51 20334883-6 2010 RESULTS: In this study, we demonstrated that the level of 5-MTHF is significantly decreased in the plasma, spinal cord and cortex at the early stages of pre-symptomatic ALS transgenic SOD1(G93A) mice while folic acid is decreased at the middle to late stages of the disease. 5-methyltetrahydrofolate 58-64 superoxide dismutase 1, soluble Mus musculus 184-188 20825051-4 2010 MTHFR catalyses the conversion of 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate which is a co-substrate in homocysteine remethylation into methionine. 5-methyltetrahydrofolate 70-94 methylenetetrahydrofolate reductase Homo sapiens 0-5 20356773-1 2010 Methylenetetrahydrofolate reductase (MTHFR) is a key enzymatic component of the folate cycle, converting 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine into methionine. 5-methyltetrahydrofolate 141-165 methylenetetrahydrofolate reductase Homo sapiens 0-35 20356773-1 2010 Methylenetetrahydrofolate reductase (MTHFR) is a key enzymatic component of the folate cycle, converting 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine into methionine. 5-methyltetrahydrofolate 141-165 methylenetetrahydrofolate reductase Homo sapiens 37-42 19917061-0 2009 [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. 5-methyltetrahydrofolate 0-29 methylenetetrahydrofolate reductase Homo sapiens 157-192 20148291-8 2010 PS ( serosal ) of 5-methyltetrahydrofolic acid was moderately decreased in Mrp3 ( -/- ) mice. 5-methyltetrahydrofolate 18-46 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Mus musculus 75-79 20148291-10 2010 CONCLUSIONS: Mrp3 accounts for the serosal efflux of folic acid and leucovorin, while it makes a moderate contribution to the serosal efflux of 5-methyltetrahydrofolic acid in mice. 5-methyltetrahydrofolate 144-172 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Mus musculus 13-17 19766516-4 2010 Under treatment CSF levels of 5MTHF, seizure frequency and communicative abilities improved. 5-methyltetrahydrofolate 30-35 laminin subunit gamma 2 Homo sapiens 16-19 19917061-1 2009 BACKGROUND AND PURPOSE: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 109-133 methylenetetrahydrofolate reductase Homo sapiens 24-64 19917061-1 2009 BACKGROUND AND PURPOSE: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 109-133 methylenetetrahydrofolate reductase Homo sapiens 66-71 19917061-1 2009 BACKGROUND AND PURPOSE: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 135-141 methylenetetrahydrofolate reductase Homo sapiens 24-64 19917061-1 2009 BACKGROUND AND PURPOSE: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is responsible for the synthesis of 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 135-141 methylenetetrahydrofolate reductase Homo sapiens 66-71 19589233-6 2009 Coadministration of folate or its analogues, such as folinate and 5-methyltetrahydrofolate, substrates for both PCFT/HCP1 and RFC1, significantly suppressed the methotrexate influx at pH 5.5, whereas thiamine pyrophosphate, an inhibitor for RFC1 alone, exerted no significant effect. 5-methyltetrahydrofolate 66-90 solute carrier family 46 member 1 Rattus norvegicus 112-121 19687280-8 2009 However, compared with the basal diet, jejunal mRNA levels of RFC were decreased (P<0.05) in hens fed with the 5-methyltetrahydrofolate diet, but the reduction did not reach significance (P=0.077) in the hens fed the folic acid diet. 5-methyltetrahydrofolate 114-138 solute carrier family 19 member 1 Gallus gallus 62-65 20073223-10 2009 CONCLUSION: THH could prevent GVHD in mice after allogeneic bone marrow transplantation, and prolong their survival time, the mechanism is possibly related with its immunosuppressive effect in raising CD4(+)CD25(+) T cells and promoting the Foxp3 mRNA expression. 5-methyltetrahydrofolate 12-15 CD4 antigen Mus musculus 201-204 20073223-10 2009 CONCLUSION: THH could prevent GVHD in mice after allogeneic bone marrow transplantation, and prolong their survival time, the mechanism is possibly related with its immunosuppressive effect in raising CD4(+)CD25(+) T cells and promoting the Foxp3 mRNA expression. 5-methyltetrahydrofolate 12-15 forkhead box P3 Mus musculus 241-246 19589233-6 2009 Coadministration of folate or its analogues, such as folinate and 5-methyltetrahydrofolate, substrates for both PCFT/HCP1 and RFC1, significantly suppressed the methotrexate influx at pH 5.5, whereas thiamine pyrophosphate, an inhibitor for RFC1 alone, exerted no significant effect. 5-methyltetrahydrofolate 66-90 solute carrier family 19 member 1 Rattus norvegicus 126-130 19589233-6 2009 Coadministration of folate or its analogues, such as folinate and 5-methyltetrahydrofolate, substrates for both PCFT/HCP1 and RFC1, significantly suppressed the methotrexate influx at pH 5.5, whereas thiamine pyrophosphate, an inhibitor for RFC1 alone, exerted no significant effect. 5-methyltetrahydrofolate 66-90 solute carrier family 19 member 1 Rattus norvegicus 241-245 20387639-6 2009 We have estimated the level of folate, components of methionine cycle--methionine and homocysteine, and related with methionine cycle cysteine and glutathione and polymorphism of methylentetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methyl-enetetrahydrofolate to 5-methyltetrahydrofolate, which serves as supplier of methyl group for methionine cycle. 5-methyltetrahydrofolate 298-322 methylenetetrahydrofolate reductase Homo sapiens 179-213 19398669-0 2009 MTHFR 677 C>T Polymorphism reveals functional importance for 5-methyltetrahydrofolate, not homocysteine, in regulation of vascular redox state and endothelial function in human atherosclerosis. 5-methyltetrahydrofolate 64-88 methylenetetrahydrofolate reductase Homo sapiens 0-5 19398669-7 2009 MTHFR genotype was a determinant of vascular 5-MTHF (not vascular homocysteine). 5-methyltetrahydrofolate 45-51 methylenetetrahydrofolate reductase Homo sapiens 0-5 19398669-8 2009 Both MTHFR genotype and vascular 5-MTHF were associated with vascular nitric oxide bioavailability and superoxide generated by uncoupled endothelial nitric oxide synthase. 5-methyltetrahydrofolate 33-39 nitric oxide synthase 3 Homo sapiens 137-170 19398669-10 2009 CONCLUSIONS: Genetic polymorphism 677 C>T on MTHFR affects vascular 5-MTHF (but not homocysteine) and can be used as a model to distinguish the chronic effects of vascular 5-MTHF from homocysteine on vascular wall. 5-methyltetrahydrofolate 71-77 methylenetetrahydrofolate reductase Homo sapiens 48-53 19398669-10 2009 CONCLUSIONS: Genetic polymorphism 677 C>T on MTHFR affects vascular 5-MTHF (but not homocysteine) and can be used as a model to distinguish the chronic effects of vascular 5-MTHF from homocysteine on vascular wall. 5-methyltetrahydrofolate 175-181 methylenetetrahydrofolate reductase Homo sapiens 48-53 19398669-11 2009 Vascular 5-MTHF, rather than plasma or vascular homocysteine, is a key regulator of endothelial nitric oxide synthase coupling and nitric oxide bioavailability in human vessels, suggesting that plasma homocysteine is an indirect marker of 5-MTHF rather than a primary regulator of endothelial function. 5-methyltetrahydrofolate 9-15 nitric oxide synthase 3 Homo sapiens 84-117 19144510-3 2009 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme of one-carbon metabolism, catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 164-188 methylenetetrahydrofolate reductase Homo sapiens 0-40 19144510-3 2009 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme of one-carbon metabolism, catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 164-188 methylenetetrahydrofolate reductase Homo sapiens 42-47 19661622-3 2009 In multivariate regression tests including age, gender, creatinine, and presence of the apolipoprotein E epsilon4 allele, P-tau181 was associated with SAH (beta = 0.490; p < 0.001), 5-MTHF (beta = -0.273; p = 0.010) levels, and SAM/SAH ratio (beta = -0.319; p = 0.013) in controls, and with SAH (beta = 0.529; p = 0.001) in AD patients. 5-methyltetrahydrofolate 182-188 apolipoprotein E Homo sapiens 88-104 19455642-2 2009 We hypothesized that children with autism who are homozygous for the MTHFR 677 T allele (TT) and, to a lesser extent those with the CT variant, would exhibit more behavioral problems and/or more severe problematic behaviors than homozygous wild-type (CC) individuals because of difficulties in effectively converting 5,10-MTHF to 5-MTHF. 5-methyltetrahydrofolate 330-336 methylenetetrahydrofolate reductase Homo sapiens 69-74 18594211-0 2008 Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro. 5-methyltetrahydrofolate 22-46 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 70-89 19133595-4 2008 To allow a sufficient supply with folic acid for persons with reduced enzymatic activity of the methylenetetrahydrofolate reductase, a supplementation with a combination of folic acid and 5-methyltetrahydrofolate can be performed. 5-methyltetrahydrofolate 188-212 methylenetetrahydrofolate reductase Homo sapiens 96-131 19277125-10 2009 In CF children, 5-MTHF and vitamin B12 supplementation (i) increased plasma and RBC folate levels; (ii) decreased plasma homocysteine levels; (iii) modified RBC membrane phospholipid fatty acid composition; (iv) increased RBC K(+) content; (v) reduced RBC membrane oxidative damage and HSP70 membrane association. 5-methyltetrahydrofolate 16-22 heat shock protein family A (Hsp70) member 4 Homo sapiens 286-291 19062539-3 2008 Methylenetetrahydrofolate reductase is the key enzyme of folate cycle, responsible for reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 134-158 methylenetetrahydrofolate reductase Homo sapiens 0-35 18594211-1 2008 Cobalamin-dependent methionine synthase, with a cofactor of vitamin B12, catalyzes the reaction of 5-methyltetrahydrofolate and homocysteine to form methionine and tetrahydrofolate, which takes a core position in folate cycle, one-carbon-unit transfer, and sulfur amino acid pathways. 5-methyltetrahydrofolate 99-123 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-39 18383508-1 2008 BACKGROUND: The reduced folate carrier (RFC1) is a ubiquitously expressed integral membrane protein that mediates delivery of 5-methyltetrahydrofolate into mammalian cells. 5-methyltetrahydrofolate 126-150 replication factor C subunit 1 Homo sapiens 40-44 18580170-9 2008 Plasma 5-methyl-tetrahydrofolate concentrations increased uniformly by 20% after nitrous oxide anesthesia, indicating the inactivation of methionine synthase and subsequent folate trapping. 5-methyltetrahydrofolate 7-32 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 138-157 18415702-2 2008 MTHFR (EC 1.5.1.20) catalyses the synthesis of 5-methyltetrahydrofolate (5-methylTHF) which is required for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 47-71 methylenetetrahydrofolate reductase Mus musculus 0-5 18539994-1 2008 Methylenetetrahydrofolate reductase catalyzes the formation of 5-methyltetrahydrofolate from 5,10-methylentetrahydrofolate and produces folate for the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 63-87 methylenetetrahydrofolate reductase Homo sapiens 0-35 18551038-3 2008 Response to the antifolate methotrexate (MTX) may be modified in 677TT individuals because MTHFR converts nonmethylated folates, used for thymidine and purine synthesis, to 5-methyltetrahydrofolate, used in homocysteine remethylation to methionine. 5-methyltetrahydrofolate 173-197 methylenetetrahydrofolate reductase Mus musculus 91-96 18415702-2 2008 MTHFR (EC 1.5.1.20) catalyses the synthesis of 5-methyltetrahydrofolate (5-methylTHF) which is required for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 73-84 methylenetetrahydrofolate reductase Mus musculus 0-5 18415702-12 2008 Mefolinate may be a good candidate drug for treatment of severe MTHFR deficiency. 5-methyltetrahydrofolate 0-10 methylenetetrahydrofolate reductase Mus musculus 64-69 18234410-4 2008 The methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in remethylation of Hcy to methionine and supplies the required 5-methyltetrahydrofolate as the methyl donor for this reaction. 5-methyltetrahydrofolate 130-154 methylenetetrahydrofolate reductase Homo sapiens 4-39 18400109-1 2008 BACKGROUND: The reduced folate carrier (RFC1) is an integral membrane protein and facilitative anion exchanger that mediates delivery of 5-methyltetrahydrofolate into mammalian cells. 5-methyltetrahydrofolate 137-161 replication factor C subunit 1 Homo sapiens 40-44 18234410-4 2008 The methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in remethylation of Hcy to methionine and supplies the required 5-methyltetrahydrofolate as the methyl donor for this reaction. 5-methyltetrahydrofolate 130-154 methylenetetrahydrofolate reductase Homo sapiens 41-46 18317335-1 2008 PURPOSE: The C677T polymorphism of methylene tetrahydrofolate reductase (MTHFR) lowers the activity of this enzyme, producing moderate elevation of blood levels of homocysteine (Hcy) and lowering the levels of 5-methyl-tetrahydro-folic acid (5-MeTHFA), methionine (Meth), and S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 210-240 methylenetetrahydrofolate reductase Homo sapiens 35-71 18086128-6 2008 FRalpha binds 5-MTHF with high affinity and facilitates efficient uptake of 5-MTHF at low extracellular folate concentrations; a lower affinity FRalpha independent system accounts for increased folate uptake at higher concentrations. 5-methyltetrahydrofolate 14-20 rabaptin, RAB GTPase binding effector protein 2 Rattus norvegicus 0-7 18086128-6 2008 FRalpha binds 5-MTHF with high affinity and facilitates efficient uptake of 5-MTHF at low extracellular folate concentrations; a lower affinity FRalpha independent system accounts for increased folate uptake at higher concentrations. 5-methyltetrahydrofolate 76-82 rabaptin, RAB GTPase binding effector protein 2 Rattus norvegicus 0-7 18086128-8 2008 5-MTHF taken up via a non-FRalpha -mediated process is rapidly metabolized to folylpolyglutamates, whereas 5-MTHF that accumulates via FRalpha remains non-metabolized, supporting the hypothesis that FRalpha may be part of a pathway for transcellular movement of the vitamin. 5-methyltetrahydrofolate 0-6 rabaptin, RAB GTPase binding effector protein 2 Rattus norvegicus 26-33 18086128-8 2008 5-MTHF taken up via a non-FRalpha -mediated process is rapidly metabolized to folylpolyglutamates, whereas 5-MTHF that accumulates via FRalpha remains non-metabolized, supporting the hypothesis that FRalpha may be part of a pathway for transcellular movement of the vitamin. 5-methyltetrahydrofolate 107-113 rabaptin, RAB GTPase binding effector protein 2 Rattus norvegicus 135-142 18086128-8 2008 5-MTHF taken up via a non-FRalpha -mediated process is rapidly metabolized to folylpolyglutamates, whereas 5-MTHF that accumulates via FRalpha remains non-metabolized, supporting the hypothesis that FRalpha may be part of a pathway for transcellular movement of the vitamin. 5-methyltetrahydrofolate 107-113 rabaptin, RAB GTPase binding effector protein 2 Rattus norvegicus 135-142 18317335-1 2008 PURPOSE: The C677T polymorphism of methylene tetrahydrofolate reductase (MTHFR) lowers the activity of this enzyme, producing moderate elevation of blood levels of homocysteine (Hcy) and lowering the levels of 5-methyl-tetrahydro-folic acid (5-MeTHFA), methionine (Meth), and S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 210-240 methylenetetrahydrofolate reductase Homo sapiens 73-78 18317335-1 2008 PURPOSE: The C677T polymorphism of methylene tetrahydrofolate reductase (MTHFR) lowers the activity of this enzyme, producing moderate elevation of blood levels of homocysteine (Hcy) and lowering the levels of 5-methyl-tetrahydro-folic acid (5-MeTHFA), methionine (Meth), and S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 242-250 methylenetetrahydrofolate reductase Homo sapiens 35-71 18317335-1 2008 PURPOSE: The C677T polymorphism of methylene tetrahydrofolate reductase (MTHFR) lowers the activity of this enzyme, producing moderate elevation of blood levels of homocysteine (Hcy) and lowering the levels of 5-methyl-tetrahydro-folic acid (5-MeTHFA), methionine (Meth), and S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 242-250 methylenetetrahydrofolate reductase Homo sapiens 73-78 18844488-2 2008 Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body. 5-methyltetrahydrofolate 150-175 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 18844488-2 2008 Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body. 5-methyltetrahydrofolate 150-175 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 21-23 17473184-0 2007 The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 138-162 folate receptor alpha Homo sapiens 4-25 19356065-1 2008 Methylenetetrahydrofolate reductase (MTHFR) gene located on chromosome 1p36.3 catalyses the conversion of 5,10-methylenetetrahydrofolate to 5,methyltetrahydrofolate, the major methyl donor for the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 140-164 methylenetetrahydrofolate reductase Homo sapiens 0-35 19356065-1 2008 Methylenetetrahydrofolate reductase (MTHFR) gene located on chromosome 1p36.3 catalyses the conversion of 5,10-methylenetetrahydrofolate to 5,methyltetrahydrofolate, the major methyl donor for the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 140-164 methylenetetrahydrofolate reductase Homo sapiens 37-42 18034621-2 2007 Optimal cytotoxicity of fluoropyrimidines requires elevated CH(2)FH(4) tumoral concentrations, controlled by the methylenetetrahydrofolate reductase (MTHFR) enzyme, which irreversibly converts CH(2)FH(4) into 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 209-233 methylenetetrahydrofolate reductase Homo sapiens 113-148 18034621-2 2007 Optimal cytotoxicity of fluoropyrimidines requires elevated CH(2)FH(4) tumoral concentrations, controlled by the methylenetetrahydrofolate reductase (MTHFR) enzyme, which irreversibly converts CH(2)FH(4) into 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 209-233 methylenetetrahydrofolate reductase Homo sapiens 150-155 17573062-2 2007 Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the methylation process catalyzing reduction of 5,10-methylenetetrahydrofolate to 5-methyl-tetrahydrofolate, C677T polymorphism, which decreases enzyme activity, may be associated with cancer susceptibility. 5-methyltetrahydrofolate 151-176 methylenetetrahydrofolate reductase Homo sapiens 6-41 17573062-2 2007 Since methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the methylation process catalyzing reduction of 5,10-methylenetetrahydrofolate to 5-methyl-tetrahydrofolate, C677T polymorphism, which decreases enzyme activity, may be associated with cancer susceptibility. 5-methyltetrahydrofolate 151-176 methylenetetrahydrofolate reductase Homo sapiens 43-48 18804702-3 2008 Methylenetetrahydrofolate reductase (MTHFR) is an important folate metabolizing enzyme that catalyzes the irreversible conversion of 5,10-methylenetretrahydrofolate, which is the methyl donor for the conversion of dUMP to dTMP, into 5-methyltetrahydrofolate, which is the methyl donor for remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 233-257 methylenetetrahydrofolate reductase Homo sapiens 0-35 18804702-3 2008 Methylenetetrahydrofolate reductase (MTHFR) is an important folate metabolizing enzyme that catalyzes the irreversible conversion of 5,10-methylenetretrahydrofolate, which is the methyl donor for the conversion of dUMP to dTMP, into 5-methyltetrahydrofolate, which is the methyl donor for remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 233-257 methylenetetrahydrofolate reductase Homo sapiens 37-42 17962486-10 2007 In X. laevis oocytes expressing the cloned mouse PCFT, folate and its derivatives methotrexate and 5-methyltetrahydrofolate induced H(+)-coupled inward currents with K(t) values of 1.2 +/- 0.1, 4.6 +/- 0.5, and 3.5 +/- 0.8 microM, respectively. 5-methyltetrahydrofolate 99-123 solute carrier family 46, member 1 Mus musculus 49-53 18058625-2 2007 Failure of ATP production in Kearns-Sayre syndrome syndrome provides one explanation for the finding of low spinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF) levels in this condition. 5-methyltetrahydrofolate 127-151 colony stimulating factor 2 Homo sapiens 122-125 18058625-2 2007 Failure of ATP production in Kearns-Sayre syndrome syndrome provides one explanation for the finding of low spinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF) levels in this condition. 5-methyltetrahydrofolate 153-158 colony stimulating factor 2 Homo sapiens 122-125 18058625-4 2007 In the present patient with mitochondrial complex I encephalomyopathy a low 5-methyltetrahydrofolate level was found in the CSF. 5-methyltetrahydrofolate 76-100 colony stimulating factor 2 Homo sapiens 124-127 17473184-8 2007 Among the transfected 143B sublines, only the 143B-FR alpha was able to uptake 5-methyltetrahydrofolate when the extracellular concentration was reduced to 2 nmol/L, which conferred a growth advantage in physiologic folate concentrations compared with vector-only-transfected cells. 5-methyltetrahydrofolate 79-103 rabaptin, RAB GTPase binding effector protein 2 Homo sapiens 51-59 17473184-10 2007 CONCLUSIONS: This study suggests that FR alpha plays a role in the uptake of 5-methyltetrahydrofolate when the concentration gradient is insufficient for RFC-mediated transport. 5-methyltetrahydrofolate 77-101 rabaptin, RAB GTPase binding effector protein 2 Homo sapiens 38-46 17098450-1 2007 Methylenetetrahydrofolate reductase (MTHFR) family of proteins catalyze the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 124-148 methylenetetrahydrofolate reductase Homo sapiens 0-35 17407503-1 2007 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 72-96 methylenetetrahydrofolate reductase Homo sapiens 11-51 17407503-1 2007 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 72-96 methylenetetrahydrofolate reductase Homo sapiens 53-58 17098450-1 2007 Methylenetetrahydrofolate reductase (MTHFR) family of proteins catalyze the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 124-148 methylenetetrahydrofolate reductase Homo sapiens 37-42 17158459-3 2007 GNMT also links utilization of preformed methyl groups, in the form of methionine, to their de novo synthesis, because it is inhibited by a specific form of folate, 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 165-189 glycine N-methyltransferase Rattus norvegicus 0-4 17367704-0 2007 5-methyltetrahydrofolic acid stimulates endothelin-1 production in low density lipoprotein-treated human endothelial cells. 5-methyltetrahydrofolate 0-28 endothelin 1 Homo sapiens 40-52 17367704-8 2007 This effect was not modified by FA or B12; however, 5-MTHF caused a concentration-dependent increase on ET-1 production, an effect coincidental with reduced TBARS production. 5-methyltetrahydrofolate 52-58 endothelin 1 Homo sapiens 104-108 17367704-9 2007 CONCLUSIONS: This study demonstrates for the first time that 5-MTHF, but not FA or B12, increases ET-1 production in LDL-treated endothelial cells. 5-methyltetrahydrofolate 61-67 endothelin 1 Homo sapiens 98-102 17158459-0 2007 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase. 5-methyltetrahydrofolate 0-24 glycine N-methyltransferase Rattus norvegicus 92-119 17158459-5 2007 We report here for the first time the crystal structure of rat GNMT complexed with 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 83-107 glycine N-methyltransferase Rattus norvegicus 63-67 17032644-1 2006 Methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) is the sole enzyme responsible for generation of 5-methyltetrahydrofolate, which is required for methionine synthesis and provision of methyl groups via S-adenosylmethionine. 5-methyltetrahydrofolate 106-130 methylenetetrahydrofolate reductase Mus musculus 37-42 16134079-1 2007 Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for the homocysteine to methionine conversion. 5-methyltetrahydrofolate 119-143 methylenetetrahydrofolate reductase Homo sapiens 0-35 16134079-1 2007 Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for the homocysteine to methionine conversion. 5-methyltetrahydrofolate 119-143 methylenetetrahydrofolate reductase Homo sapiens 37-42 17222188-1 2007 The cobalamin-dependent cytosolic enzyme, methionine synthase (EC.2.1.1.13), catalyzes the remethylation of homocysteine to methionine using 5-methyltetrahydrofolate as the methyl donor. 5-methyltetrahydrofolate 141-165 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 42-61 17032644-6 2006 MTHFR null mutants (mthfr(-)) lacked 5-methyltetrahydrofolate, the most abundant intracellular folate, and could not utilize exogenous homocysteine for growth. 5-methyltetrahydrofolate 37-61 methylenetetrahydrofolate reductase Mus musculus 0-5 17032644-6 2006 MTHFR null mutants (mthfr(-)) lacked 5-methyltetrahydrofolate, the most abundant intracellular folate, and could not utilize exogenous homocysteine for growth. 5-methyltetrahydrofolate 37-61 methylenetetrahydrofolate reductase Mus musculus 20-25 16944145-1 2006 Methylenetetrahydrofolate reductase (MTHFR) is one of the most critical enzyme in folic acid metabolism, and it converts 5,10-MTHF to 5-MTHF. 5-methyltetrahydrofolate 134-140 methylenetetrahydrofolate reductase Homo sapiens 0-35 16835399-2 2006 Because the folate-dependent one-carbon pool is a source of methyl groups and 5-methyltetrahydrofolate allosterically inhibits GNMT, the aim of this study was to determine whether folate status has an impact on the interaction between diabetes and methyl group metabolism. 5-methyltetrahydrofolate 78-102 glycine N-methyltransferase Rattus norvegicus 127-131 16944145-1 2006 Methylenetetrahydrofolate reductase (MTHFR) is one of the most critical enzyme in folic acid metabolism, and it converts 5,10-MTHF to 5-MTHF. 5-methyltetrahydrofolate 134-140 methylenetetrahydrofolate reductase Homo sapiens 37-42 15492840-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 0-35 16933051-5 2006 Methylene tetrahydrofolate reductase (MTHFR) metabolizes 5,10-MTHF (important in DNA synthesis) to 5-MTHF (contributes to downstream methylation reactions by regeneration of methionine from homocysteine). 5-methyltetrahydrofolate 99-105 methylenetetrahydrofolate reductase Homo sapiens 0-36 16933051-5 2006 Methylene tetrahydrofolate reductase (MTHFR) metabolizes 5,10-MTHF (important in DNA synthesis) to 5-MTHF (contributes to downstream methylation reactions by regeneration of methionine from homocysteine). 5-methyltetrahydrofolate 99-105 methylenetetrahydrofolate reductase Homo sapiens 38-43 16988141-7 2006 With regard to polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), the modeling predicts that decrease MTHFR activity reduces concentrations of S-adenosylmethionine and 5-methyltetrahydrofolate, as well as DNA methylation, while modestly increasing S-adenosylhomocysteine and homocysteine concentrations and thymidine or purine synthesis. 5-methyltetrahydrofolate 184-208 methylenetetrahydrofolate reductase Homo sapiens 32-72 16988141-7 2006 With regard to polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), the modeling predicts that decrease MTHFR activity reduces concentrations of S-adenosylmethionine and 5-methyltetrahydrofolate, as well as DNA methylation, while modestly increasing S-adenosylhomocysteine and homocysteine concentrations and thymidine or purine synthesis. 5-methyltetrahydrofolate 184-208 methylenetetrahydrofolate reductase Homo sapiens 74-79 16988141-7 2006 With regard to polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), the modeling predicts that decrease MTHFR activity reduces concentrations of S-adenosylmethionine and 5-methyltetrahydrofolate, as well as DNA methylation, while modestly increasing S-adenosylhomocysteine and homocysteine concentrations and thymidine or purine synthesis. 5-methyltetrahydrofolate 184-208 methylenetetrahydrofolate reductase Homo sapiens 118-123 16940192-0 2006 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and endothelial nitric oxide synthase coupling. 5-methyltetrahydrofolate 0-24 nitric oxide synthase 3 Homo sapiens 174-207 16627483-5 2006 Both low and high FDH expression reduced total cellular folate concentrations by 60%, elevated rates of folate catabolism, and depleted cellular 5-methyl-THF and S-adenosylmethionine levels. 5-methyltetrahydrofolate 145-157 aldehyde dehydrogenase 1 family member L1 Homo sapiens 18-21 16627483-10 2006 FDH expression does deplete cellular 5-methyl-THF and S-adenosylmethionine levels indicating that FDH impairs the folate-dependent homocysteine remethylation cycle. 5-methyltetrahydrofolate 37-49 aldehyde dehydrogenase 1 family member L1 Homo sapiens 0-3 16187112-2 2006 Methylenetetrahydrofolate reductase (MTHFR) may play a central role in the action of 5-FU, an inhibitor of thymidylate synthase, by converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 177-201 methylenetetrahydrofolate reductase Homo sapiens 0-35 16187112-2 2006 Methylenetetrahydrofolate reductase (MTHFR) may play a central role in the action of 5-FU, an inhibitor of thymidylate synthase, by converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 177-201 methylenetetrahydrofolate reductase Homo sapiens 37-42 16187112-2 2006 Methylenetetrahydrofolate reductase (MTHFR) may play a central role in the action of 5-FU, an inhibitor of thymidylate synthase, by converting 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 177-201 thymidylate synthetase Homo sapiens 107-127 16173969-0 2005 Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype. 5-methyltetrahydrofolate 43-67 methylenetetrahydrofolate reductase Homo sapiens 134-169 15781839-1 2005 The authors describe a 6-year-old girl with developmental delay, psychomotor regression, seizures, mental retardation, and autistic features associated with low CSF levels of 5-methyltetrahydrofolate, the biologically active form of folates in CSF and blood. 5-methyltetrahydrofolate 175-199 colony stimulating factor 2 Homo sapiens 161-164 15781839-1 2005 The authors describe a 6-year-old girl with developmental delay, psychomotor regression, seizures, mental retardation, and autistic features associated with low CSF levels of 5-methyltetrahydrofolate, the biologically active form of folates in CSF and blood. 5-methyltetrahydrofolate 175-199 colony stimulating factor 2 Homo sapiens 244-247 16162503-8 2005 Insertional inactivation of At2g32040 significantly raised the total folate content of chloroplasts and lowered the proportion of 5-methyltetrahydrofolate but did not discernibly affect growth. 5-methyltetrahydrofolate 130-154 Major facilitator superfamily protein Arabidopsis thaliana 28-37 16230283-1 2005 The 5,10 methylene tetrahydrofolate reductase (MTHFR) is an enzyme that catalyzes the irreversible reduction of 5,10 methylene tetrahydrofolate into 5 methyl tetrahydrofolate. 5-methyltetrahydrofolate 149-174 methylenetetrahydrofolate reductase Homo sapiens 9-45 16230283-1 2005 The 5,10 methylene tetrahydrofolate reductase (MTHFR) is an enzyme that catalyzes the irreversible reduction of 5,10 methylene tetrahydrofolate into 5 methyl tetrahydrofolate. 5-methyltetrahydrofolate 149-174 methylenetetrahydrofolate reductase Homo sapiens 47-52 15979267-2 2005 MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 84-108 methylenetetrahydrofolate reductase Mus musculus 0-5 15979267-2 2005 MTHFR is a critical enzyme in folate metabolism; the product of the MTHFR reaction, 5-methyltetrahydrofolate, is required for homocysteine remethylation to methionine and synthesis of S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 84-108 methylenetetrahydrofolate reductase Mus musculus 68-73 15781665-5 2005 MTX inhibits the synthesis of dTMP needed for DNA replication by blocking the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by MTHFR. 5-methyltetrahydrofolate 126-150 methylenetetrahydrofolate reductase Homo sapiens 154-159 15548731-2 2005 Within the folate pathway, methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a methyl donor for remethylation of homocysteine to methionine, the precursor of S-adenosylmethionine. 5-methyltetrahydrofolate 113-137 methylenetetrahydrofolate reductase Homo sapiens 27-62 15548731-2 2005 Within the folate pathway, methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a methyl donor for remethylation of homocysteine to methionine, the precursor of S-adenosylmethionine. 5-methyltetrahydrofolate 113-137 methylenetetrahydrofolate reductase Homo sapiens 64-69 15681105-0 2005 Distribution of 5,10-methylenetetrahydrofolate reductase (C667T) polymorphism and its association with red blood cell 5-methyltetrahydrofolate in the healthy Iranians. 5-methyltetrahydrofolate 118-142 methylenetetrahydrofolate reductase Homo sapiens 21-56 15875363-1 2005 PURPOSE: Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 146-171 RFT1 homolog Homo sapiens 9-37 15875363-1 2005 PURPOSE: Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 146-171 RFT1 homolog Homo sapiens 39-44 15875363-1 2005 PURPOSE: Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 173-176 RFT1 homolog Homo sapiens 9-37 15875363-1 2005 PURPOSE: Reduced-folate transporter-1 (RFT-1), a typical transport protein with 12 membrane-spanning domains, transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 173-176 RFT1 homolog Homo sapiens 39-44 15598791-2 2004 Reduction of 5,10-methylenetetrahydrofolate, a donor for methylating dUMP to dTMP in DNA synthesis, to 5-methyltetrahydrofolate, the primary methyl donor for methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 103-127 methylenetetrahydrofolate reductase Homo sapiens 196-236 15598791-2 2004 Reduction of 5,10-methylenetetrahydrofolate, a donor for methylating dUMP to dTMP in DNA synthesis, to 5-methyltetrahydrofolate, the primary methyl donor for methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 103-127 methylenetetrahydrofolate reductase Homo sapiens 238-243 15608557-1 2004 Methylenetetrahydrofolate reductase (MTHFR) controls intracellular CH2FH4 concentrations (required for optimal fluoropyrimidine efficacy) by irreversibly converting CH2FH4 into 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 177-201 methylenetetrahydrofolate reductase Homo sapiens 0-35 15608557-1 2004 Methylenetetrahydrofolate reductase (MTHFR) controls intracellular CH2FH4 concentrations (required for optimal fluoropyrimidine efficacy) by irreversibly converting CH2FH4 into 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 177-201 methylenetetrahydrofolate reductase Homo sapiens 37-42 15337749-1 2004 Reduced folates such as 5-methyl tetrahydrofolate and classical antifolates such as methotrexate are actively transported into mammalian cells by the reduced folate carrier (RFC). 5-methyltetrahydrofolate 24-49 solute carrier family 19 member 1 Homo sapiens 150-172 15337749-1 2004 Reduced folates such as 5-methyl tetrahydrofolate and classical antifolates such as methotrexate are actively transported into mammalian cells by the reduced folate carrier (RFC). 5-methyltetrahydrofolate 24-49 solute carrier family 19 member 1 Homo sapiens 174-177 15492840-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 37-42 15048559-1 2004 Methylenetetrahydrofolate reductase (MTHFR) is the only route for the synthesis of 5-methyltetrahydrofolate, which is utilized to convert homocysteine to methionine. 5-methyltetrahydrofolate 83-107 methylenetetrahydrofolate reductase Homo sapiens 37-42 15789174-3 2004 Methionine regenerates by retrieving the methyl radical from 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylentetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 61-85 methylenetetrahydrofolate reductase Homo sapiens 186-220 15789174-3 2004 Methionine regenerates by retrieving the methyl radical from 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylentetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 87-93 methylenetetrahydrofolate reductase Homo sapiens 186-220 15789174-3 2004 Methionine regenerates by retrieving the methyl radical from 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylentetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 87-93 methylenetetrahydrofolate reductase Homo sapiens 222-227 15789174-3 2004 Methionine regenerates by retrieving the methyl radical from 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylentetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 157-163 methylenetetrahydrofolate reductase Homo sapiens 186-220 15789174-3 2004 Methionine regenerates by retrieving the methyl radical from 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylentetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 157-163 methylenetetrahydrofolate reductase Homo sapiens 222-227 15048559-1 2004 Methylenetetrahydrofolate reductase (MTHFR) is the only route for the synthesis of 5-methyltetrahydrofolate, which is utilized to convert homocysteine to methionine. 5-methyltetrahydrofolate 83-107 methylenetetrahydrofolate reductase Homo sapiens 0-35 14722319-6 2004 These results suggest that rOat3 and RFC-1 are almost equally involved in the uptake of MTX by the kidney slices, whereas RFC-1 is responsible for the renal uptake of 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 167-191 replication factor C subunit 1 Rattus norvegicus 122-127 14769778-2 2004 Methylenetetrahydrofolate reductase (MTHFR) is a regulating enzyme in folate-dependant homocysteine remethylation, because it catalyses the reduction of 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 187-211 methylenetetrahydrofolate reductase Homo sapiens 0-35 14769778-2 2004 Methylenetetrahydrofolate reductase (MTHFR) is a regulating enzyme in folate-dependant homocysteine remethylation, because it catalyses the reduction of 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 187-211 methylenetetrahydrofolate reductase Homo sapiens 37-42 14769778-2 2004 Methylenetetrahydrofolate reductase (MTHFR) is a regulating enzyme in folate-dependant homocysteine remethylation, because it catalyses the reduction of 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 213-219 methylenetetrahydrofolate reductase Homo sapiens 0-35 14769778-2 2004 Methylenetetrahydrofolate reductase (MTHFR) is a regulating enzyme in folate-dependant homocysteine remethylation, because it catalyses the reduction of 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 213-219 methylenetetrahydrofolate reductase Homo sapiens 37-42 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Mus musculus 0-35 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Mus musculus 37-42 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 97-108 methylenetetrahydrofolate reductase Mus musculus 0-35 15514261-1 2004 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), which is used for homocysteine remethylation to methionine, the precursor of S-adenosylmethionine (SAM). 5-methyltetrahydrofolate 97-108 methylenetetrahydrofolate reductase Mus musculus 37-42 15326182-1 2004 Cobalamin-independent methionine synthase (MetE) catalyzes the synthesis of methionine by a direct transfer of the methyl group of N5-methyltetrahydrofolate (CH3-H2PteGlun) to the sulfur atom of homocysteine (Hcy). 5-methyltetrahydrofolate 131-156 Cobalamin-independent synthase family protein Arabidopsis thaliana 0-41 15217352-1 2004 MTHFR (methylenetetrahydrofolate reductase) catalyses the synthesis of 5-methyltetrahydrofolate, the folate derivative utilized in homocysteine remethylation to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Mus musculus 0-5 15217352-1 2004 MTHFR (methylenetetrahydrofolate reductase) catalyses the synthesis of 5-methyltetrahydrofolate, the folate derivative utilized in homocysteine remethylation to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Mus musculus 7-42 15353309-7 2004 Data from in vitro studies utilizing colon cancer cell lines suggest that supplemental folic acid or its metabolite 5-methyltetrahydrofolate (5-MTF) attenuates the expression and activation of EGF-receptor (EGFR) as well as proliferation of cells. 5-methyltetrahydrofolate 116-140 epidermal growth factor receptor Homo sapiens 193-205 15353309-7 2004 Data from in vitro studies utilizing colon cancer cell lines suggest that supplemental folic acid or its metabolite 5-methyltetrahydrofolate (5-MTF) attenuates the expression and activation of EGF-receptor (EGFR) as well as proliferation of cells. 5-methyltetrahydrofolate 116-140 epidermal growth factor receptor Homo sapiens 207-211 15353309-7 2004 Data from in vitro studies utilizing colon cancer cell lines suggest that supplemental folic acid or its metabolite 5-methyltetrahydrofolate (5-MTF) attenuates the expression and activation of EGF-receptor (EGFR) as well as proliferation of cells. 5-methyltetrahydrofolate 142-147 epidermal growth factor receptor Homo sapiens 193-205 15353309-7 2004 Data from in vitro studies utilizing colon cancer cell lines suggest that supplemental folic acid or its metabolite 5-methyltetrahydrofolate (5-MTF) attenuates the expression and activation of EGF-receptor (EGFR) as well as proliferation of cells. 5-methyltetrahydrofolate 142-147 epidermal growth factor receptor Homo sapiens 207-211 15094208-1 2004 Folate receptor alpha (FRalpha), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus. 5-methyltetrahydrofolate 150-174 folate receptor alpha Homo sapiens 0-21 15094208-1 2004 Folate receptor alpha (FRalpha), a glycosyl phosphatidylinositol linked protein with a great affinity for folic acid and some reduced folates such as 5-methyltetrahydrofolate and tetrahydrofolate is present on a limited number of epithelial cells, especially the kidney, placenta and choroid plexus. 5-methyltetrahydrofolate 150-174 FOS like 1, AP-1 transcription factor subunit Homo sapiens 23-30 14609557-1 2003 Reduced-folate transporter-1 (RFT-1) transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 73-98 RFT1 homolog Homo sapiens 0-28 15319544-1 2004 BACKGROUND: Methionine synthase (MTR) synthesizes methionine from homocysteine, using cobalamin as a cofactor and 5-methyltetrahydrofolate as a cosubstrate. 5-methyltetrahydrofolate 114-138 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 12-31 14609557-1 2003 Reduced-folate transporter-1 (RFT-1) transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 73-98 RFT1 homolog Homo sapiens 30-35 14609557-1 2003 Reduced-folate transporter-1 (RFT-1) transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 100-103 RFT1 homolog Homo sapiens 0-28 14609557-1 2003 Reduced-folate transporter-1 (RFT-1) transports reduced-folates, such as N5-methyltetrahydrofolate (MTF), the predominant circulating form of folate. 5-methyltetrahydrofolate 100-103 RFT1 homolog Homo sapiens 30-35 12949355-6 2003 Similarly, the proportion of 5-methyltetrahydrofolate in cells with the T/T genotype was approximately half that of the cells with wild-type MTHFR. 5-methyltetrahydrofolate 29-53 methylenetetrahydrofolate reductase Homo sapiens 141-146 12949355-1 2003 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the methyl donor for the synthesis of methionine from homocysteine. 5-methyltetrahydrofolate 105-129 methylenetetrahydrofolate reductase Homo sapiens 0-35 12949355-1 2003 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the methyl donor for the synthesis of methionine from homocysteine. 5-methyltetrahydrofolate 105-129 methylenetetrahydrofolate reductase Homo sapiens 37-42 14585765-3 2003 One such enzyme, methylenetetrahydrofolate reductase (MTHFR), synthesizes 5-methyltetrahydrofolate, utilized in homocysteine remethylation to methionine. 5-methyltetrahydrofolate 74-98 methylenetetrahydrofolate reductase Homo sapiens 17-52 14585765-3 2003 One such enzyme, methylenetetrahydrofolate reductase (MTHFR), synthesizes 5-methyltetrahydrofolate, utilized in homocysteine remethylation to methionine. 5-methyltetrahydrofolate 74-98 methylenetetrahydrofolate reductase Homo sapiens 54-59 14608093-0 2003 Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after the addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model. 5-methyltetrahydrofolate 35-64 folate receptor alpha Homo sapiens 97-119 14577615-1 2003 Methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the major carbon donor in the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 86-110 methylenetetrahydrofolate reductase Homo sapiens 0-35 14577615-1 2003 Methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the major carbon donor in the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 86-110 methylenetetrahydrofolate reductase Homo sapiens 37-42 12963755-4 2003 Abnormal CSF findings included extremely high neopterin (293 to 814 nmol/L; normal 12 to 30 nmol/L) and biopterin (226 to 416 nmol/L; normal 15 to 40 nmol/L) combined with lowered 5-methyltetrahydrofolate (23 to 48 nmol/L; normal 64 to 182 nmol/L) concentrations in two patients. 5-methyltetrahydrofolate 180-204 colony stimulating factor 2 Homo sapiens 9-12 12809644-1 2003 The folate receptor beta (FRbeta) gene encodes a receptor that binds and transports 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 84-108 folate receptor beta Homo sapiens 4-24 12809644-1 2003 The folate receptor beta (FRbeta) gene encodes a receptor that binds and transports 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 84-108 folate receptor beta Homo sapiens 26-32 12673793-1 2003 Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, a major methyl donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 56-80 methylenetetrahydrofolate reductase Homo sapiens 0-35 12673793-1 2003 Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, a major methyl donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 56-80 methylenetetrahydrofolate reductase Homo sapiens 37-42 12672677-2 2003 Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methyltetrahydrofolate, the predominant circulating form of folate. 5-methyltetrahydrofolate 93-117 methylenetetrahydrofolate reductase Homo sapiens 21-56 12738713-2 2003 Methylenetetrahydrofolate reductase (MTHFR) could play an important role in the action of 5-FU, an inhibitor of thymidylate synthetase, by converting 5,10-methylenetetrahydrofolate, a substrate of thymidylate synthetase, to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 224-248 methylenetetrahydrofolate reductase Homo sapiens 0-35 12738713-2 2003 Methylenetetrahydrofolate reductase (MTHFR) could play an important role in the action of 5-FU, an inhibitor of thymidylate synthetase, by converting 5,10-methylenetetrahydrofolate, a substrate of thymidylate synthetase, to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 224-248 methylenetetrahydrofolate reductase Homo sapiens 37-42 12672677-2 2003 Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methyltetrahydrofolate, the predominant circulating form of folate. 5-methyltetrahydrofolate 93-117 methylenetetrahydrofolate reductase Homo sapiens 58-63 12590471-2 2003 Folates were extracted from juices, and the polyglutamyl side chain of 5-MTHFA was cleaved to the monoglutamate form using rat plasma conjugase. 5-methyltetrahydrofolate 71-78 gamma-glutamyl hydrolase Rattus norvegicus 134-143 12560354-2 2003 MTHFR catalyzes the formation of 5-methyltetrahydrofolate, which acts as a methyl donor for homocysteine remethylation. 5-methyltetrahydrofolate 33-57 methylenetetrahydrofolate reductase Homo sapiens 0-5 12576444-3 2003 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5",10"-methylenetetrahydrofolate to 5"-methyl tetrahydrofolate, which serves as methyl donor in the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 108-134 methylenetetrahydrofolate reductase Homo sapiens 37-42 12576444-3 2003 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5",10"-methylenetetrahydrofolate to 5"-methyl tetrahydrofolate, which serves as methyl donor in the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 108-134 methylenetetrahydrofolate reductase Homo sapiens 0-35 12473740-3 2003 5-MeTHF is the methyl group donor required for the conversion of homocysteine to methionine catalyzed by vitamin B(12)-dependent methionine synthase. 5-methyltetrahydrofolate 0-7 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 105-148 12571785-2 2002 The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 166-190 folate receptor alpha Homo sapiens 4-21 12453860-1 2002 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, a common mutation of the gene encoding the enzyme that catalyzes reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor in the metabolism of folate, determines a striking reduction in the enzyme activity in carriers of mutation at homozygous status. 5-methyltetrahydrofolate 188-212 methylenetetrahydrofolate reductase Homo sapiens 12-47 12453860-1 2002 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, a common mutation of the gene encoding the enzyme that catalyzes reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor in the metabolism of folate, determines a striking reduction in the enzyme activity in carriers of mutation at homozygous status. 5-methyltetrahydrofolate 188-212 methylenetetrahydrofolate reductase Homo sapiens 49-54 12571785-2 2002 The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 166-190 folate receptor alpha Homo sapiens 23-27 12571785-2 2002 The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 192-198 folate receptor alpha Homo sapiens 4-21 12571785-2 2002 The folate receptor-1 (FR 1) protein is localized at the basolateral surface of the choroid plexus, which is characterized by a high binding affinity for circulating 5-methyltetrahydrofolate (5-MTHF). 5-methyltetrahydrofolate 192-198 folate receptor alpha Homo sapiens 23-27 12161434-6 2002 Increases in cSHMT expression inhibit SAM concentrations by two proposed mechanisms: (1) cSHMT-catalyzed serine synthesis competes with the enzyme methylenetetrahydrofolate reductase for methylenetetrahydrofolate in a glycine-dependent manner, and (2) cSHMT, a high affinity 5-methyltetrahydrofolate-binding protein, sequesters this cofactor and inhibits methionine synthesis in a glycine-independent manner. 5-methyltetrahydrofolate 275-299 serine hydroxymethyltransferase 1 Homo sapiens 13-18 12406076-1 2002 Deficiency in methylenetetrahydrofolate reductase (MTHFR), the enzyme involved in the remethylation of homocysteine to methionine using methyltetrahydrofolate as cofactor, induces hyperhomocysteinaemia, homocysteinuria, hypomethioninaemia and low methylfolate levels. 5-methyltetrahydrofolate 247-259 methylenetetrahydrofolate reductase Homo sapiens 14-49 12406076-1 2002 Deficiency in methylenetetrahydrofolate reductase (MTHFR), the enzyme involved in the remethylation of homocysteine to methionine using methyltetrahydrofolate as cofactor, induces hyperhomocysteinaemia, homocysteinuria, hypomethioninaemia and low methylfolate levels. 5-methyltetrahydrofolate 247-259 methylenetetrahydrofolate reductase Homo sapiens 51-56 12370778-1 2002 Methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the major carbon donor in the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 86-110 methylenetetrahydrofolate reductase Homo sapiens 0-35 12370778-1 2002 Methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the major carbon donor in the remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 86-110 methylenetetrahydrofolate reductase Homo sapiens 37-42 12107847-2 2002 Methylenetetrahydrofolate reductase synthesises 5-methyltetrahydrofolate, the methyl donor utilised in methionine synthesis from homocysteine by vitamin B(12)-dependent methionine synthase. 5-methyltetrahydrofolate 48-72 methylenetetrahydrofolate reductase Homo sapiens 0-35 12107847-2 2002 Methylenetetrahydrofolate reductase synthesises 5-methyltetrahydrofolate, the methyl donor utilised in methionine synthesis from homocysteine by vitamin B(12)-dependent methionine synthase. 5-methyltetrahydrofolate 48-72 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 145-188 12089131-1 2002 We report on a child in whom severe nutritional vitamin B12 deficiency was exacerbated by a genetic impairment of the folate cycle, causing reduced CSF concentrations of the methyl group donor 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 193-217 colony stimulating factor 2 Homo sapiens 148-151 12161434-8 2002 We conclude that cSHMT has three important functions in the cytoplasm: (1) it preferentially supplies one-carbon units for thymidylate biosynthesis, (2) it depletes methylenetetrahydrofolate pools for SAM synthesis by synthesizing serine, and (3) it sequesters 5-methyltetrahydrofolate and inhibits SAM synthesis. 5-methyltetrahydrofolate 261-285 serine hydroxymethyltransferase 1 Homo sapiens 17-22 12161434-6 2002 Increases in cSHMT expression inhibit SAM concentrations by two proposed mechanisms: (1) cSHMT-catalyzed serine synthesis competes with the enzyme methylenetetrahydrofolate reductase for methylenetetrahydrofolate in a glycine-dependent manner, and (2) cSHMT, a high affinity 5-methyltetrahydrofolate-binding protein, sequesters this cofactor and inhibits methionine synthesis in a glycine-independent manner. 5-methyltetrahydrofolate 275-299 serine hydroxymethyltransferase 1 Homo sapiens 89-94 12161434-6 2002 Increases in cSHMT expression inhibit SAM concentrations by two proposed mechanisms: (1) cSHMT-catalyzed serine synthesis competes with the enzyme methylenetetrahydrofolate reductase for methylenetetrahydrofolate in a glycine-dependent manner, and (2) cSHMT, a high affinity 5-methyltetrahydrofolate-binding protein, sequesters this cofactor and inhibits methionine synthesis in a glycine-independent manner. 5-methyltetrahydrofolate 275-299 serine hydroxymethyltransferase 1 Homo sapiens 89-94 12028998-3 2002 METHODS: To measure MTHFR in the physiologic direction, we determined the NADPH-dependent conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate by use of HPLC with fluorescence detection. 5-methyltetrahydrofolate 138-162 methylenetetrahydrofolate reductase Homo sapiens 20-25 12015164-2 2002 A reaction catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR) supplies 5-methyltetrahydrofolate, needed to remethylate homocysteine to methionine. 5-methyltetrahydrofolate 82-106 methylenetetrahydrofolate reductase Homo sapiens 24-64 12015164-2 2002 A reaction catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR) supplies 5-methyltetrahydrofolate, needed to remethylate homocysteine to methionine. 5-methyltetrahydrofolate 82-106 methylenetetrahydrofolate reductase Homo sapiens 66-71 11929966-2 2002 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), the methyl donor for synthesis of methionine from homocysteine and precursor of S-adenosyl-l-methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 0-35 11929966-2 2002 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), the methyl donor for synthesis of methionine from homocysteine and precursor of S-adenosyl-l-methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 37-42 11929966-2 2002 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), the methyl donor for synthesis of methionine from homocysteine and precursor of S-adenosyl-l-methionine. 5-methyltetrahydrofolate 97-108 methylenetetrahydrofolate reductase Homo sapiens 0-35 11929966-2 2002 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate (5-methylTHF), the methyl donor for synthesis of methionine from homocysteine and precursor of S-adenosyl-l-methionine. 5-methyltetrahydrofolate 97-108 methylenetetrahydrofolate reductase Homo sapiens 37-42 11751445-2 2001 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 0-35 11818404-4 2002 METHODS: Human ARPE-19 cells were incubated in media containing 5 mM glucose plus 40 mM mannitol (control) or 45 mM glucose for varying periods and the activity of RFT-1 was assessed by determining the uptake of [3H]-N(5)-methyltetrahydrofolate (MTF). 5-methyltetrahydrofolate 246-249 RFT1 homolog Homo sapiens 164-169 11823591-1 2002 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 0-35 11823591-1 2002 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 37-42 11810299-7 2002 GNMT is also inhibited by a specific form of folate, 5-methyltetrahydrofolate pentaglutamate. 5-methyltetrahydrofolate 53-77 glycine N-methyltransferase Homo sapiens 0-4 11730351-0 2001 Assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring 5-methyltetrahydrofolate and tetrahydrofolate using high-performance liquid chromatography with fluorescence detection. 5-methyltetrahydrofolate 95-119 methylenetetrahydrofolate reductase Homo sapiens 10-45 11730351-0 2001 Assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring 5-methyltetrahydrofolate and tetrahydrofolate using high-performance liquid chromatography with fluorescence detection. 5-methyltetrahydrofolate 95-119 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 50-69 11730351-1 2001 We developed a method for assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring their products of 5-methyltetrahydrofolate (5-CH(3)-H(4)folate) and tetrahydrofolate (H(4)folate) directly, using high-performance liquid chromatography with fluorescence detection. 5-methyltetrahydrofolate 139-163 methylenetetrahydrofolate reductase Homo sapiens 36-71 11730351-1 2001 We developed a method for assays of methylenetetrahydrofolate reductase and methionine synthase activities by monitoring their products of 5-methyltetrahydrofolate (5-CH(3)-H(4)folate) and tetrahydrofolate (H(4)folate) directly, using high-performance liquid chromatography with fluorescence detection. 5-methyltetrahydrofolate 139-163 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 76-95 12166823-0 2001 Binding of radiolabeled folate and 5-methyltetrahydrofolate to cow"s milk folate binding protein at pH 7.4 and 5.0. 5-methyltetrahydrofolate 35-59 folate receptor alpha Bos taurus 69-96 11751445-2 2001 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, which is involved in the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 37-42 11408344-1 2001 Methylenetetrahydrofolate reductase (MTHFR) is an enzyme which converts 5,10-methylene tetrahydrofolate (5,10-MnTHF) to 5-methyl tetrahydrofolate. 5-methyltetrahydrofolate 120-145 methylenetetrahydrofolate reductase Homo sapiens 0-35 11721146-4 2001 Moreover, the homozygous mutation (C677T) of the methylene tetrahydrofolate reductase (MTHFR) gene, related to a thermolabile type of the encoded enzyme, causes hyperhomocysteinemia by reducing the 5-methyltetrahydrofolate availability. 5-methyltetrahydrofolate 198-222 methylenetetrahydrofolate reductase Homo sapiens 49-85 11721146-4 2001 Moreover, the homozygous mutation (C677T) of the methylene tetrahydrofolate reductase (MTHFR) gene, related to a thermolabile type of the encoded enzyme, causes hyperhomocysteinemia by reducing the 5-methyltetrahydrofolate availability. 5-methyltetrahydrofolate 198-222 methylenetetrahydrofolate reductase Homo sapiens 87-92 11408344-1 2001 Methylenetetrahydrofolate reductase (MTHFR) is an enzyme which converts 5,10-methylene tetrahydrofolate (5,10-MnTHF) to 5-methyl tetrahydrofolate. 5-methyltetrahydrofolate 120-145 methylenetetrahydrofolate reductase Homo sapiens 37-42 11386854-5 2001 In one out of five patients a low CSF 5-methyltetrahydrofolate (MTHF) was present probably due to the common C677T heterozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. 5-methyltetrahydrofolate 38-62 methylenetetrahydrofolate reductase Homo sapiens 144-179 11430769-2 2001 In human subjects, orally-administered pure unnatural C-6 isomers, [6R]-5-formyltetrahydrofolate and [6S]-5,10-methenyltetrahydrofolate, were recently shown to be metabolized to the natural isomer, [6S]-5-methyltetrahydrofolate. 5-methyltetrahydrofolate 198-227 complement C6 Homo sapiens 54-57 11386854-5 2001 In one out of five patients a low CSF 5-methyltetrahydrofolate (MTHF) was present probably due to the common C677T heterozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. 5-methyltetrahydrofolate 38-62 methylenetetrahydrofolate reductase Homo sapiens 181-186 11386854-5 2001 In one out of five patients a low CSF 5-methyltetrahydrofolate (MTHF) was present probably due to the common C677T heterozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. 5-methyltetrahydrofolate 64-68 methylenetetrahydrofolate reductase Homo sapiens 144-179 11386854-5 2001 In one out of five patients a low CSF 5-methyltetrahydrofolate (MTHF) was present probably due to the common C677T heterozygous mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. 5-methyltetrahydrofolate 64-68 methylenetetrahydrofolate reductase Homo sapiens 181-186 11274972-3 2001 Intracellular folate cofactor levels increased almost in proportion to the increase in extracellular 5-formyltetrahydrofolate (5-CHO-THF) over a concentration range that encompassed physiological levels of 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 206-230 thin fur Mus musculus 133-136 11282795-1 2001 Methylenetetrahydrofolate reductase (MTHFR) is involved in the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 110-134 methylenetetrahydrofolate reductase Homo sapiens 0-35 11282795-1 2001 Methylenetetrahydrofolate reductase (MTHFR) is involved in the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 110-134 methylenetetrahydrofolate reductase Homo sapiens 37-42 11266438-1 2001 The reduced folate carrier (RFC1) is an important route by which the major blood folate, 5-methyltetrahydrofolate, is transported into mammalian cells. 5-methyltetrahydrofolate 89-113 replication factor C subunit 1 Homo sapiens 28-32 11161947-2 2001 Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C allele exclusively accumulate 5methyltetrahydrofolate, the methyl donor for homocysteine remethylation, in their red blood cells; this contrasts with 677 TT homozygotes who also accumulate significant levels of non-methylated folate derivatives. 5-methyltetrahydrofolate 110-133 methylenetetrahydrofolate reductase Homo sapiens 31-66 11257268-1 2001 Methionine synthase (MS) encodes an enzyme that catalyzes the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate, which is the major circulating form of folate in the body. 5-methyltetrahydrofolate 138-162 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 11257268-1 2001 Methionine synthase (MS) encodes an enzyme that catalyzes the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate, which is the major circulating form of folate in the body. 5-methyltetrahydrofolate 138-162 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 21-23 11237340-6 2001 Both the spectrophotometric and the radiometric methods are based on the conversion of 5-methyltetrahydrofolate to tetrahydrofolate by methionine synthase. 5-methyltetrahydrofolate 87-111 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 135-154 11161947-2 2001 Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C allele exclusively accumulate 5methyltetrahydrofolate, the methyl donor for homocysteine remethylation, in their red blood cells; this contrasts with 677 TT homozygotes who also accumulate significant levels of non-methylated folate derivatives. 5-methyltetrahydrofolate 110-133 methylenetetrahydrofolate reductase Homo sapiens 68-73 11137375-6 2001 5-methyltetrahydrofolate, the product of the MTHFR reaction, was able to decrease the incidence of antisense-induced NTDs, but co-injection with L-methionine did not. 5-methyltetrahydrofolate 0-24 methylenetetrahydrofolate reductase Mus musculus 45-50 11129814-3 2000 We hypothesize that topical hepatic hypothermia (THH) reduces ischemia and reperfusion-induced hepatic necrosis, PMN infiltration, TNF-alpha release, and consequent acute pulmonary injury. 5-methyltetrahydrofolate 49-52 tumor necrosis factor Rattus norvegicus 131-140 11101483-7 2000 We propose that [(2)H(2)]methionine occurs by remethylation with [(2)H(2)]methyl groups (as 5-methyltetrahydrofolate) formed only from cytosolic processing of [(2)H(3)]serine, whereas [(2)H(1)]methionine is formed with labeled one-carbon units from mitochondrial oxidation of C-3 serine to [(2)H(1)]formate to yield cytosolic [(2)H(1)]methyl groups. 5-methyltetrahydrofolate 92-116 complement C3 Homo sapiens 276-279 11098041-2 2000 The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. 5-methyltetrahydrofolate 230-254 methylenetetrahydrofolate reductase Homo sapiens 58-93 11098041-2 2000 The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. 5-methyltetrahydrofolate 230-254 methylenetetrahydrofolate reductase Homo sapiens 95-100 11098041-2 2000 The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. 5-methyltetrahydrofolate 256-268 methylenetetrahydrofolate reductase Homo sapiens 58-93 11098041-2 2000 The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. 5-methyltetrahydrofolate 256-268 methylenetetrahydrofolate reductase Homo sapiens 95-100 11129814-10 2000 Institution of THH reduced peak serum TNF-alpha levels by 54% at 15 minutes (p < 0.005) and by 73% at 30 minutes (p < 0.001) postreperfusion compared with normothermic I/R. 5-methyltetrahydrofolate 15-18 tumor necrosis factor Rattus norvegicus 38-47 11129814-12 2000 Myeloperoxidase activity and Evans blue extravasation (measures of acute lung injury) were reduced by 42% and 39%, respectively, with institution of THH compared with animals undergoing normothermic I/R (p < 0.001). 5-methyltetrahydrofolate 149-152 myeloperoxidase Rattus norvegicus 0-15 11129814-14 2000 In addition, THH reduces the serum levels of TNF-alpha and associated pulmonary injury. 5-methyltetrahydrofolate 13-16 tumor necrosis factor Rattus norvegicus 45-54 11076529-1 2000 N5-Methyltetrahydrofolate (CH(3)-H(4)folate) donates a methyl group to the cob(I)alamin cofactor in the reaction catalyzed by cobalamin-dependent methionine synthase (MetH, EC 2.1.1.3). 5-methyltetrahydrofolate 0-25 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 126-165 11508546-4 2000 Low concentrations of the amino acids serine, glycine as well as 5-methyltetrahydrofolate were found in plasma and CSF and were due to a deficiency of the enzyme 3-phosphoglycerate dehydrogenase (3-PGDH). 5-methyltetrahydrofolate 65-89 phosphoglycerate dehydrogenase Homo sapiens 162-194 11508546-4 2000 Low concentrations of the amino acids serine, glycine as well as 5-methyltetrahydrofolate were found in plasma and CSF and were due to a deficiency of the enzyme 3-phosphoglycerate dehydrogenase (3-PGDH). 5-methyltetrahydrofolate 65-89 phosphoglycerate dehydrogenase Homo sapiens 196-202 11508552-2 2000 Decreased activity of MTHFR leads to reduction of 5-methyltetrahydrofolate, the main methyl donor for methionine synthesis necessary for synthesis of S-adenosyl-methionine (SAM). 5-methyltetrahydrofolate 50-74 methylenetetrahydrofolate reductase Homo sapiens 22-27 11086190-8 2000 This method is simple, very sensitive and measures directly the reduction of N(5), N(10)-methylenetetrahydrofolate to N(5)-methyltetrahydrofolate, which is the physiologic catalytic pathway for methylenetetrahydrofolate reductase. 5-methyltetrahydrofolate 118-145 methylenetetrahydrofolate reductase Rattus norvegicus 194-229 10958818-1 2000 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolic acid (5-CH(3)-H(4) folic acid), the methyl donor for the formation of methionine from homocysteine. 5-methyltetrahydrofolate 71-99 methylenetetrahydrofolate reductase Homo sapiens 0-35 10958818-1 2000 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolic acid (5-CH(3)-H(4) folic acid), the methyl donor for the formation of methionine from homocysteine. 5-methyltetrahydrofolate 71-99 methylenetetrahydrofolate reductase Homo sapiens 37-42 10787414-6 2000 These studies, done with N(5)-methyltetrahydrofolate (the predominant folate derivative in blood) and folate as substrates, have shown that RFT-1 functions in a Na(+)- and C1(-)-independent manner. 5-methyltetrahydrofolate 25-52 RFT1 homolog Homo sapiens 140-145 10952104-2 2000 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for methionine synthesis and the precursor of S-adenosylmethionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 37-42 10952104-2 2000 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for methionine synthesis and the precursor of S-adenosylmethionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 0-35 10666493-3 2000 It is known that the polymorphism of methylenetetrahydrofolate reductase (MTHFR), the enzyme catalyzing the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, correlates with hyperhomocysteinemia. 5-methyltetrahydrofolate 156-180 methylenetetrahydrofolate reductase Homo sapiens 37-72 10919734-1 2000 A common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, where a cytosine at nucleotide 677 is replaced by a thymine (677C-->T), is associated with enzyme thermolability and a reduction in the conversion of 5,10-methyltetrahydrofolate (5,10-MTHF) into 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 277-301 methylenetetrahydrofolate reductase Homo sapiens 29-64 10919734-1 2000 A common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, where a cytosine at nucleotide 677 is replaced by a thymine (677C-->T), is associated with enzyme thermolability and a reduction in the conversion of 5,10-methyltetrahydrofolate (5,10-MTHF) into 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 277-301 methylenetetrahydrofolate reductase Homo sapiens 66-71 10780318-10 2000 A 4-week administration of 5-methyltetrahydrofolate (15 mg/day) markedly lowered plasma tHcy in 24 patients with MTHFR 677TT genotype, but the response to treatment correlated with vitamin B,2 levels (p = 0.023). 5-methyltetrahydrofolate 27-51 methylenetetrahydrofolate reductase Homo sapiens 113-118 10666493-3 2000 It is known that the polymorphism of methylenetetrahydrofolate reductase (MTHFR), the enzyme catalyzing the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, correlates with hyperhomocysteinemia. 5-methyltetrahydrofolate 156-180 methylenetetrahydrofolate reductase Homo sapiens 74-79 10742662-8 2000 The reduced plasma homocysteine and folate concentrations and reduced percentage of hepatic 5-methyltetrahydrofolate are probably secondary to the increased activity of hepatic methionine synthase in zinc deficiency. 5-methyltetrahydrofolate 92-116 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 177-196 10536004-1 1999 Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP to dTMP in DNA synthesis, to 5-methyltetrahydrofolate (methylTHF), the primary methyl donor for methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 118-142 methylenetetrahydrofolate reductase Homo sapiens 223-263 10600168-2 1999 MTHFR catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, used to methylate homocysteine in methionine synthesis. 5-methyltetrahydrofolate 68-92 methylenetetrahydrofolate reductase Homo sapiens 0-5 10535753-3 1999 The level of expression of carrier in the cell lines studied was determined by specific surface binding of 5-methyltetrahydrofolate (5-CH3-THF). 5-methyltetrahydrofolate 107-131 thin fur Mus musculus 139-142 10551815-1 1999 Human methylenetetrahydrofolate reductase (MTHFR, EC 1.5.1.20) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 124-148 methylenetetrahydrofolate reductase Homo sapiens 6-41 10551815-1 1999 Human methylenetetrahydrofolate reductase (MTHFR, EC 1.5.1.20) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 124-148 methylenetetrahydrofolate reductase Homo sapiens 43-48 10923034-1 2000 Methylenetetrahydrofolate reductase (MTHFR) catalyses the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 105-129 methylenetetrahydrofolate reductase Homo sapiens 0-35 10923034-1 2000 Methylenetetrahydrofolate reductase (MTHFR) catalyses the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 105-129 methylenetetrahydrofolate reductase Homo sapiens 37-42 10536004-1 1999 Reduction of 5,10-methylenetetrahydrofolate (methyleneTHF), a donor for methylating dUMP to dTMP in DNA synthesis, to 5-methyltetrahydrofolate (methylTHF), the primary methyl donor for methionine synthesis, is catalyzed by 5,10-methylenetetrahydrofolate reductase (MTHFR). 5-methyltetrahydrofolate 118-142 methylenetetrahydrofolate reductase Homo sapiens 265-270 10948708-3 1999 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the synthesis of 5-methyltetrahydrofolate, the methyl donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 80-104 methylenetetrahydrofolate reductase Homo sapiens 0-35 10948708-3 1999 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the synthesis of 5-methyltetrahydrofolate, the methyl donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 80-104 methylenetetrahydrofolate reductase Homo sapiens 37-42 10444343-3 1999 Methionine synthase catalyzes the vitamin B(12)-dependent conversion of homocysteine and 5-methyltetrahydrofolate to methionine and tetrahydrofolate. 5-methyltetrahydrofolate 89-113 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 9781030-2 1998 MTHFR is a key enzyme in folate-dependent remethylation of homocysteine, and reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 119-143 methylenetetrahydrofolate reductase Homo sapiens 0-5 10102280-8 1999 A heterologous functional expression assay using MTX(R)-ZR-75-1 cells showed that the folate receptor alpha cDNA obtained by RT-PCR from the RPE/choroid complex and the neural retina was functional as assessed by the binding of folic acid and by the uptake of N5-methyltetrahydrofolate. 5-methyltetrahydrofolate 260-285 folate receptor 1 (adult) Mus musculus 86-107 9680386-0 1998 Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 184-208 methylenetetrahydrofolate reductase Mus musculus 34-69 9680386-0 1998 Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 184-208 methylenetetrahydrofolate reductase Mus musculus 71-76 9680386-0 1998 Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 184-208 methylenetetrahydrofolate reductase Homo sapiens 78-113 9680386-0 1998 Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR) Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 184-208 methylenetetrahydrofolate reductase Homo sapiens 115-120 10222379-1 1999 A common genetic polymorphism results from a C-->T substitution in the gene encoding methylenetetrahydrofolate reductase (MTHFR), the enzyme that produces 5-methyltetrahydrofolate (5-methyl-THF) required for the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 158-182 methylenetetrahydrofolate reductase Homo sapiens 88-123 10222379-1 1999 A common genetic polymorphism results from a C-->T substitution in the gene encoding methylenetetrahydrofolate reductase (MTHFR), the enzyme that produces 5-methyltetrahydrofolate (5-methyl-THF) required for the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 158-182 methylenetetrahydrofolate reductase Homo sapiens 125-130 10222379-1 1999 A common genetic polymorphism results from a C-->T substitution in the gene encoding methylenetetrahydrofolate reductase (MTHFR), the enzyme that produces 5-methyltetrahydrofolate (5-methyl-THF) required for the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 184-196 methylenetetrahydrofolate reductase Homo sapiens 88-123 10222379-1 1999 A common genetic polymorphism results from a C-->T substitution in the gene encoding methylenetetrahydrofolate reductase (MTHFR), the enzyme that produces 5-methyltetrahydrofolate (5-methyl-THF) required for the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 184-196 methylenetetrahydrofolate reductase Homo sapiens 125-130 9972236-1 1998 Methionine synthase catalyzes cobalamin-dependent methyl transfer reaction from 5-methyltetrahydrofolate to homocysteine, forming methionine. 5-methyltetrahydrofolate 80-104 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 0-19 9493571-2 1998 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the cofactor for the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 105-129 methylenetetrahydrofolate reductase Homo sapiens 0-35 9493571-2 1998 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the cofactor for the methylation of homocysteine to methionine. 5-methyltetrahydrofolate 105-129 methylenetetrahydrofolate reductase Homo sapiens 37-42 9462523-0 1998 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. 5-methyltetrahydrofolate 0-24 low density lipoprotein receptor Homo sapiens 90-119 9462523-3 1998 Because folates have been suggested to stimulate endogenous BH4 regeneration, we hypothesized that administration of 5-methyltetrahydrofolate (5-MTHF, the active circulating form of folate) might improve NO formation in FH. 5-methyltetrahydrofolate 117-141 low density lipoprotein receptor Homo sapiens 220-222 9462523-3 1998 Because folates have been suggested to stimulate endogenous BH4 regeneration, we hypothesized that administration of 5-methyltetrahydrofolate (5-MTHF, the active circulating form of folate) might improve NO formation in FH. 5-methyltetrahydrofolate 143-149 low density lipoprotein receptor Homo sapiens 220-222 9278558-0 1997 Compartmentation of folate metabolism in rat pancreas: nitrous oxide inactivation of methionine synthase leads to accumulation of 5-methyltetrahydrofolate in cytosol. 5-methyltetrahydrofolate 130-154 5-methyltetrahydrofolate-homocysteine methyltransferase Rattus norvegicus 85-104 9458739-10 1998 Similarly, uptake of folic acid and 5-methyltetrahydrofolate (5-MTHF) by IEC-6/RFC was found to be fourfold higher than uptake in control sublines. 5-methyltetrahydrofolate 36-60 solute carrier family 19 (folate transporter), member 1 L homeolog Xenopus laevis 79-82 9458739-10 1998 Similarly, uptake of folic acid and 5-methyltetrahydrofolate (5-MTHF) by IEC-6/RFC was found to be fourfold higher than uptake in control sublines. 5-methyltetrahydrofolate 62-68 solute carrier family 19 (folate transporter), member 1 L homeolog Xenopus laevis 79-82 9458739-11 1998 This increase in folic acid and 5-MTHF uptake was inhibited by treating IEC-6/RFC cells with cholesterol-modified antisense DNA oligonucleotides. 5-methyltetrahydrofolate 32-38 solute carrier family 19 (folate transporter), member 1 L homeolog Xenopus laevis 78-81 9458739-13 1998 In both IEC-6/RFC and control sublines, the uptake of both folic acid and 5-MTHF displayed 1) pH dependency, with a higher uptake at acidic pH 5.5 compared with pH 7.5, and 2) inhibition to the same extent by both reduced and oxidized folate derivatives. 5-methyltetrahydrofolate 74-80 solute carrier family 19 (folate transporter), member 1 L homeolog Xenopus laevis 14-17 9488247-8 1998 We propose that infants with mutations in the folate receptor alpha gene might be at increased risk for congenital anomalies due to a reduced binding affinity for 5-methyltetrahydrofolate, the physiologic form of folic acid. 5-methyltetrahydrofolate 163-187 folate receptor alpha Homo sapiens 46-67 9462523-7 1998 The impaired endothelium-dependent vasodilation in FH (63% versus 90% in control subjects) could be reversed by coinfusion of 5-MTHF (117% vasodilation), whereas 5-MTHF had no significant effect on endothelium-dependent vasodilation in control subjects. 5-methyltetrahydrofolate 126-132 low density lipoprotein receptor Homo sapiens 51-53 9067278-2 1997 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymidine syntheses, to 5-methyltetrahydrofolate, the primary circulatory form of folate necessary for methionine synthesis. 5-methyltetrahydrofolate 168-192 methylenetetrahydrofolate reductase Homo sapiens 11-51 9108260-1 1997 Methionine synthase, the enzyme that catalyses the transfer of a methyl group from 5-methyl tetrahydrofolate to homocysteine via the cofactor methylcobalamin, is one of the two established mammalian enzymes that utilise a biologically active vitamin B-12 derivative. 5-methyltetrahydrofolate 83-108 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 9327028-11 1997 Our data rather favour the involvement of genetic variation at loci coding for the formation of 5-methyltetrahydrofolate, such as MTHFR, methylenetetrahydrofolate dehydrogenase or serine hydroxymethyltransferase. 5-methyltetrahydrofolate 96-120 methylenetetrahydrofolate reductase Homo sapiens 130-135 9178098-1 1997 We investigated whether the folate receptor alpha-isoform (FR alpha), which is overexpressed on ovarian carcinoma cells, is functionally active in internalizing the physiological form et folate, 5-methyl tetrahydrofolate (THF). 5-methyltetrahydrofolate 195-220 folate receptor alpha Homo sapiens 28-49 9178098-1 1997 We investigated whether the folate receptor alpha-isoform (FR alpha), which is overexpressed on ovarian carcinoma cells, is functionally active in internalizing the physiological form et folate, 5-methyl tetrahydrofolate (THF). 5-methyltetrahydrofolate 195-220 FOS like 1, AP-1 transcription factor subunit Homo sapiens 59-67 9067278-3 1997 A common mutation (677C-->T) in MTHFR reduces enzyme activity, leading to lower levels of 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 93-117 methylenetetrahydrofolate reductase Homo sapiens 35-40 9102178-2 1997 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 0-35 9102178-2 1997 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, the methyl donor for homocysteine remethylation to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 37-42 9067278-2 1997 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymidine syntheses, to 5-methyltetrahydrofolate, the primary circulatory form of folate necessary for methionine synthesis. 5-methyltetrahydrofolate 168-192 methylenetetrahydrofolate reductase Homo sapiens 53-58 8940272-1 1996 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, a methyl donor in the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 0-35 9099956-1 1997 The high-affinity folate-binding protein (FBP) is primarily involved in the uptake of the 5-methyltetrahydrofolate, and its expression may be physiologically regulated by the intracellular folate content. 5-methyltetrahydrofolate 90-114 folate receptor beta Homo sapiens 42-45 9099956-3 1997 We tested the hypothesis of the existence of a defect in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) in ovarian tumours that could cause reduced intracellular regeneration of the 5-methyltetrahydrofolate and induce increased FBP expression. 5-methyltetrahydrofolate 189-213 methylenetetrahydrofolate reductase Homo sapiens 64-102 9099956-3 1997 We tested the hypothesis of the existence of a defect in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) in ovarian tumours that could cause reduced intracellular regeneration of the 5-methyltetrahydrofolate and induce increased FBP expression. 5-methyltetrahydrofolate 189-213 methylenetetrahydrofolate reductase Homo sapiens 104-109 8940272-1 1996 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the synthesis of 5-methyltetrahydrofolate, a methyl donor in the conversion of homocysteine to methionine. 5-methyltetrahydrofolate 71-95 methylenetetrahydrofolate reductase Homo sapiens 37-42 8921781-3 1996 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate, which serves as a methyl donor for remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 121-145 methylenetetrahydrofolate reductase Homo sapiens 11-51 8921781-3 1996 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate, which serves as a methyl donor for remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 121-145 methylenetetrahydrofolate reductase Homo sapiens 53-58 8595169-3 1996 In FBP-transfected NIH/3T3 (FBP-tNIH/3T3) cells, which internalised about three times more 5-methyltetrahydrofolic acid than the mock-transfected cells, the cytotoxtic potential of DDATHF showed a clear increase. 5-methyltetrahydrofolate 91-119 far upstream element (FUSE) binding protein 1 Mus musculus 28-31 8664315-6 1996 An 11-fold increase in 5-methyltetrahydrofolate (5-MTHF) uptake was observed in oocytes injected with 10 ng IFC1(RFC1) cRNA compared to water-injected controls. 5-methyltetrahydrofolate 23-47 solute carrier family 19 (folate transporter), member 1 Mus musculus 108-112 8616944-1 1996 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, the major carbon donor in remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 68-92 methylenetetrahydrofolate reductase Homo sapiens 12-47 8616944-1 1996 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, the major carbon donor in remethylation of homocysteine to methionine. 5-methyltetrahydrofolate 68-92 methylenetetrahydrofolate reductase Homo sapiens 49-54 8664315-6 1996 An 11-fold increase in 5-methyltetrahydrofolate (5-MTHF) uptake was observed in oocytes injected with 10 ng IFC1(RFC1) cRNA compared to water-injected controls. 5-methyltetrahydrofolate 23-47 replication factor C (activator 1) 1 Mus musculus 113-117 8664315-6 1996 An 11-fold increase in 5-methyltetrahydrofolate (5-MTHF) uptake was observed in oocytes injected with 10 ng IFC1(RFC1) cRNA compared to water-injected controls. 5-methyltetrahydrofolate 49-55 solute carrier family 19 (folate transporter), member 1 Mus musculus 108-112 8664315-6 1996 An 11-fold increase in 5-methyltetrahydrofolate (5-MTHF) uptake was observed in oocytes injected with 10 ng IFC1(RFC1) cRNA compared to water-injected controls. 5-methyltetrahydrofolate 49-55 replication factor C (activator 1) 1 Mus musculus 113-117 8595169-3 1996 In FBP-transfected NIH/3T3 (FBP-tNIH/3T3) cells, which internalised about three times more 5-methyltetrahydrofolic acid than the mock-transfected cells, the cytotoxtic potential of DDATHF showed a clear increase. 5-methyltetrahydrofolate 91-119 far upstream element (FUSE) binding protein 1 Mus musculus 3-6 8069855-8 1994 Both of these parameters, as well as the cellular content of the substrate 5-methyltetrahydrofolate, and the cofactor methylcobalamin, in addition to adenosylcobalamin, were high in P10, declined progressively in P45 and P60, and were restored in P60R. 5-methyltetrahydrofolate 75-99 S100 calcium binding protein A10 Homo sapiens 182-185 8572314-1 1995 Methionine synthase enzymes catalyze methyl group transfer from 5-methyltetrahydrofolate to homocysteine to give methionine and tetrahydrofolate. 5-methyltetrahydrofolate 64-88 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 21552807-1 1995 5-methyltetrahydrofolate (MTHF) is a main serum metabolite of 5-formyltetrahydrofolate (folinic acid, FA), a standard agent for potentiation of the cytotoxic activity of 5-fluorouracil (5-FU). 5-methyltetrahydrofolate 0-24 thin fur Mus musculus 26-30 7647779-3 1995 5, 10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate and carbon donor for the re-methylation of homocysteine to methionine. 5-methyltetrahydrofolate 112-136 methylenetetrahydrofolate reductase Homo sapiens 6-41 7647779-3 1995 5, 10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate and carbon donor for the re-methylation of homocysteine to methionine. 5-methyltetrahydrofolate 112-136 methylenetetrahydrofolate reductase Homo sapiens 43-48 7826387-5 1995 When transfected into COS-1 and HeLa cells, the hFOLT cDNA causes a significant increase in the uptake of 5-methyltetrahydrofolate. 5-methyltetrahydrofolate 106-130 solute carrier family 19 member 1 Homo sapiens 48-53 8069855-9 1994 P25 cells had some unique features among the methionine-independent phenotypes because both homocysteine remethylation and the level of 5-methyltetrahydrofolate were low in Met+Hcy- medium. 5-methyltetrahydrofolate 136-160 tubulin polymerization promoting protein Homo sapiens 0-3 8461049-3 1993 FdUMP binding to TS was also stimulated by tetrahydrofolate and dihydrofolate (85% and 30% as compared to (6RS)-CH2-H4-folate, respectively), but not by the stereoisomers of 5-methyl-tetrahydrofolate and 5-formyl-tetrahydrofolate (leucovorin). 5-methyltetrahydrofolate 174-199 thymidylate synthetase Homo sapiens 17-19 8005024-3 1994 The folate cofactor, N5-methyltetrahydrofolate, donates its methyl group to a vitamin B12-dependent enzyme, methionine synthase, which recycles homocysteine back to methionine. 5-methyltetrahydrofolate 21-46 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 108-127 8005024-5 1994 Methionine synthase plays another role: it converts circulating N5-methyltetrahydrofolate into tetrahydrofolate. 5-methyltetrahydrofolate 64-89 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 8099783-2 1993 Methylmalonyl-CoA mutase isomerizes L-methylmalonyl-CoA to succinyl-CoA in the propionyl-CoA pathway while methionine synthase catalyzes the transfer of the methyl group of 5-methyltetrahydrofolate to homocysteine to form methionine. 5-methyltetrahydrofolate 173-197 methylmalonyl-CoA mutase Homo sapiens 0-24 8099783-2 1993 Methylmalonyl-CoA mutase isomerizes L-methylmalonyl-CoA to succinyl-CoA in the propionyl-CoA pathway while methionine synthase catalyzes the transfer of the methyl group of 5-methyltetrahydrofolate to homocysteine to form methionine. 5-methyltetrahydrofolate 173-197 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 107-126 7830239-1 1994 The protein binding of the tetrahydrofolates folinic acid (FA) and its metabolite 5-methyltetrahydrofolic acid (5-MTHF) to human serum albumin (HSA) is stereoselective. 5-methyltetrahydrofolate 82-110 albumin Homo sapiens 129-142 7830239-1 1994 The protein binding of the tetrahydrofolates folinic acid (FA) and its metabolite 5-methyltetrahydrofolic acid (5-MTHF) to human serum albumin (HSA) is stereoselective. 5-methyltetrahydrofolate 112-118 albumin Homo sapiens 129-142 1602376-7 1992 The methionine synthase inactivation increased in a dose-dependent manner when the 5-methyltetrahydrofolate content of the medium was increased from 3 nM to 2.3 microM. 5-methyltetrahydrofolate 83-107 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 4-23 8398300-14 1993 Pharmacokinetics of oral LV was performed in patients treated with and without alpha-IF: significantly higher serum levels of LV and 5-methyltetrahydrofolate were found after alpha-IF addition. 5-methyltetrahydrofolate 133-157 interferon alpha 2 Homo sapiens 175-183 2407589-1 1990 Cobalamin-dependent methionine synthase catalyzes the transfer of a methyl group from N5-methyltetrahydrofolate to homocysteine, producing tetrahydrofolate and methionine. 5-methyltetrahydrofolate 86-111 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-39 1744096-1 1991 Methionine synthase catalyzes the conversion of N5-methyltetrahydrofolate and homocysteine to tetrahydrofolate and methionine. 5-methyltetrahydrofolate 48-73 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 1795217-2 1991 This vitamin takes part in the activity of the enzyme methylmalonyl coenzyme A mutase, involved in the conversion of propionyl CoA to succinyl CoA, an intermediary product of the citrate cycle, and of the 5-methyltetrahydrofolate: homocystein methyltransferase, working in the metabolism of methionin and in DNA synthesis. 5-methyltetrahydrofolate 205-229 methylmalonyl-CoA mutase Homo sapiens 54-85 1733262-4 1992 Uptake of 5-methyltetrahydrofolate was linear for the first 30 s and was more rapid when an initial pH gradient was imposed across the vesicular membrane [extravesicular pH (pHo) = 5.0, intravesicular pH (pHi) = 7.5]. 5-methyltetrahydrofolate 10-34 glucose-6-phosphate isomerase Rattus norvegicus 205-208 2195551-3 1990 Reduced folates (LV and 5-methyltetrahydrofolate) at concentrations greater than or equal to 1 microM can, by raising the intracellular levels of 5,10-methylenetetrahydrofolate, increase and prolong the inhibition of the target enzyme, thymidylate synthase, with formation of a stable ternary complex formed by the enzyme, the folate coenzyme and the fluoropyrimidine inhibitor (5-fluorodeoxyuridylate). 5-methyltetrahydrofolate 24-48 thymidylate synthetase Homo sapiens 236-256 34799699-2 2021 The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR). 5-methyltetrahydrofolate 48-73 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 182-201 34834493-1 2021 The cerebral folate receptor alpha (FRalpha) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). 5-methyltetrahydrofolate 56-80 folate receptor alpha Homo sapiens 13-34 34834493-1 2021 The cerebral folate receptor alpha (FRalpha) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). 5-methyltetrahydrofolate 56-80 FOS like 1, AP-1 transcription factor subunit Homo sapiens 36-43 34834493-1 2021 The cerebral folate receptor alpha (FRalpha) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). 5-methyltetrahydrofolate 82-88 folate receptor alpha Homo sapiens 13-34 34834493-1 2021 The cerebral folate receptor alpha (FRalpha) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). 5-methyltetrahydrofolate 82-88 FOS like 1, AP-1 transcription factor subunit Homo sapiens 36-43 34834493-1 2021 The cerebral folate receptor alpha (FRalpha) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). 5-methyltetrahydrofolate 110-116 folate receptor alpha Homo sapiens 13-34 34834493-1 2021 The cerebral folate receptor alpha (FRalpha) transports 5-methyltetrahydrofolate (5-MTHF) into the brain; low 5-MTHF in the brain causes cerebral folate deficiency (CFD). 5-methyltetrahydrofolate 110-116 FOS like 1, AP-1 transcription factor subunit Homo sapiens 36-43 34799699-2 2021 The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR). 5-methyltetrahydrofolate 75-87 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 182-201 34799701-3 2021 We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source. 5-methyltetrahydrofolate 163-188 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 77-96 34799701-4 2021 In such physiological conditions, methionine synthase incorporates 5-methyl THF into the folate cycle to maintain intracellular levels of the folates needed for nucleotide production. 5-methyltetrahydrofolate 67-79 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 34-53 34718458-4 2021 RESULTS: The detection limits of DVUDLLME-HPLC were 0.21 ng mL-1, 0.18 ng mL-1 and 55 pgmL-1 for vitamin B9, 5-MeTHF and vitamin B12, respectively. 5-methyltetrahydrofolate 109-116 L1 cell adhesion molecule Mus musculus 60-64 34718458-4 2021 RESULTS: The detection limits of DVUDLLME-HPLC were 0.21 ng mL-1, 0.18 ng mL-1 and 55 pgmL-1 for vitamin B9, 5-MeTHF and vitamin B12, respectively. 5-methyltetrahydrofolate 109-116 L1 cell adhesion molecule Mus musculus 74-78 34829516-3 2021 We found that CRIF1 downregulation caused significant increases in intracellular and plasma concentrations of homocysteine, which were associated with decreased levels of folate cycle intermediates such as 5-methyltetrahydrofolate (MTHF) and tetrahydrofolate (THF). 5-methyltetrahydrofolate 206-230 growth arrest and DNA-damage-inducible, gamma interacting protein 1 Mus musculus 14-19 34829516-3 2021 We found that CRIF1 downregulation caused significant increases in intracellular and plasma concentrations of homocysteine, which were associated with decreased levels of folate cycle intermediates such as 5-methyltetrahydrofolate (MTHF) and tetrahydrofolate (THF). 5-methyltetrahydrofolate 232-236 growth arrest and DNA-damage-inducible, gamma interacting protein 1 Mus musculus 14-19 34665710-4 2021 Thus, this study aimed to investigate the in vitro rescuing effect of different folates including folic acid (FA), 5-methyltetrahydrofolate (MTHF) and folinic acid (5-Formyltetrahydrofolic acid, FTHF) on MTX-treated trophoblast cells. 5-methyltetrahydrofolate 115-139 metaxin 1 Homo sapiens 204-207 34665710-4 2021 Thus, this study aimed to investigate the in vitro rescuing effect of different folates including folic acid (FA), 5-methyltetrahydrofolate (MTHF) and folinic acid (5-Formyltetrahydrofolic acid, FTHF) on MTX-treated trophoblast cells. 5-methyltetrahydrofolate 141-145 metaxin 1 Homo sapiens 204-207 34502300-3 2021 Methylenetetrahydrofolate reductase (MTHFR) is the enzyme catalyzing the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that can control folate cofactor distributions and modulate the partitioning of intracellular one-carbon moieties. 5-methyltetrahydrofolate 134-158 methylenetetrahydrofolate reductase Homo sapiens 0-35 34502300-3 2021 Methylenetetrahydrofolate reductase (MTHFR) is the enzyme catalyzing the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that can control folate cofactor distributions and modulate the partitioning of intracellular one-carbon moieties. 5-methyltetrahydrofolate 134-158 methylenetetrahydrofolate reductase Homo sapiens 37-42 34251183-10 2021 The increased tumor-to-kidney ratios obtained with (177Lu)Lu-6R-RedFol-1 and (177Lu)Lu-6S-RedFol-1 as compared to (177Lu)Lu-OxFol-1 indicated that 5-MTHF is the preferred FR-targeting agent for albumin-binding radioconjugates. 5-methyltetrahydrofolate 147-153 albumin Homo sapiens 194-201 34311437-8 2021 The established ID-UPLC-MS method was successfully applied to various volumes of human plasma or serum ranging from 500 to 10 muL, which exhibited particularly good sensitivity in addition to reliable results for the quantification of 5-Me-THF. 5-methyltetrahydrofolate 235-243 tripartite motif containing 37 Homo sapiens 126-129