PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7678009-7	1993	The connexin-56-transfected cells demonstrated intercellular coupling by transfer of microinjected 6-carboxyfluorescein.	6-carboxyfluorescein	99-119	gap junction protein alpha 3	Gallus gallus	4-15
1485537-4	1992	Then carboxyfluorescein-entrapped indicator liposomes containing ganglioside GD3 and complement were added.	6-carboxyfluorescein	5-23	GRDX	Homo sapiens	77-80
1384706-6	1992	The leakage experiment of 5,6-carboxyfluorescein encapsulated in DPPC liposomes showed that the activities of melittin 1-22 and melittin-lac in membrane lysis were much lower than melittin.	6-carboxyfluorescein	26-48	lactase	Homo sapiens	137-140
1423928-3	1992	In HCO3(-)-free buffer (pHo 7.4), 5-HT (10(-5) M) increased pHi, as measured by 2",7"-bis(2-carboxyethyl)-5(6)-carboxyfluorescein fluorescence, from 7.10 +/- 0.03 to 7.34 +/- 0.03 (p < 0.01) in primary cultures of canine femoral artery vascular smooth muscle cells grown to confluence in the presence of 10% fetal calf serum.	6-carboxyfluorescein	109-129	glucose-6-phosphate isomerase	Rattus norvegicus	60-63
1581336-1	1992	The interactions of salmon calcitonin with glycosphingolipid sulfatide are studied by right angle light scattering from the lipid suspension, by the excimer to monomer ratio (E/M) of the fluorescence intensity of pyrene phosphatidylcholine and pyrene sulfatide and by the leakage of carboxyfluorescein.	6-carboxyfluorescein	283-301	calcitonin related polypeptide alpha	Homo sapiens	27-37
1617703-5	1992	Carboxyfluorescein and counting of the surrounding labelled cells showed that supplementation with follicle-stimulating hormone, forskolin, insulin-like growth factor type I and epidermal growth factor from the beginning of cultivation led to an increase in stained cells after 48 h. When treatment was started in 48 h cultures the substances reached their maximal activity within 30 min (forskolin and epidermal growth factor) or 3 h (follicle-stimulating hormone and insulin-like growth factor type I).	6-carboxyfluorescein	0-18	pro-epidermal growth factor	Callithrix jacchus	178-201
1581336-7	1992	Furthermore, the addition of calcitonin to the incubation medium of liposomes containing sulfatide promoted the release of vesicle entrapped carboxyfluorescein without disrupting the bilayer structure, the release being correlated with the amount of sulfatide in the bilayer and the calcitonin concentration in the medium.	6-carboxyfluorescein	141-159	calcitonin related polypeptide alpha	Homo sapiens	29-39
16309861-5	2006	After the noise exposure, the cochleae were examined for the activity of caspase-3 with carboxyfluorescein-labeled fluoromethyl ketone (FMK)-peptide inhibitors.	6-carboxyfluorescein	88-106	caspase-3	Cavia porcellus	73-82
2382444-4	1990	pHi changes were recorded by computer-assisted spectrofluorimetric monitoring of the pH-sensitive, fluorescent dye BCECF (2",7"-bis(carboxyethyl)- 5(6)carboxyfluorescein).	6-carboxyfluorescein	151-169	glucose-6-phosphate isomerase	Homo sapiens	0-3
2159800-2	1990	Neuropeptide Y binding was demonstrated by a rapid release of entrapped 6-carboxyfluorescein and a rapid decrease in the turbidity of dimyristoylphosphatidylcholine liposomes.	6-carboxyfluorescein	72-92	neuropeptide Y	Homo sapiens	0-14
2350550-9	1990	PGLa mixed with a small nonperturbing amount of magainin 2 amide is 25-43 times as potent as PGLa alone at inducing the release of carboxyfluorescein from liposomes.	6-carboxyfluorescein	131-149	prepro-PGLa S homeolog	Xenopus laevis	0-4
2350550-9	1990	PGLa mixed with a small nonperturbing amount of magainin 2 amide is 25-43 times as potent as PGLa alone at inducing the release of carboxyfluorescein from liposomes.	6-carboxyfluorescein	131-149	prepro-PGLa S homeolog	Xenopus laevis	93-97
34716495-2	2021	According to the sequence of microRNA-21, carboxy-fluorescein (FAM)-labeled hybridization probe 1 (FAM-H1) and hybridization probes 2 (FAM-H2) were designed with excitation maxima at 488 nm and emission maxima at 518 nm.	6-carboxyfluorescein	42-61	microRNA 21	Homo sapiens	29-40
34963932-2	2021	Here, we test K-rich peptides from plant dehydrin ERD14 (ERD-A, ERD-B, and ERD-C) and the C-terminal CPP-resembling region of S100A4 (S100) using the 5(6)-carboxyfluorescein (Cf) tag at the N-terminus.	6-carboxyfluorescein	155-173	S100 calcium binding protein A4	Homo sapiens	126-132
2795489-6	1989	Histological characterization of electrophysiologically identified mPRF neurones with carboxyfluorescein showed no definite morphological difference between the first two classes.	6-carboxyfluorescein	86-104	Spi-C transcription factor (Spi-1/PU.1 related)	Mus musculus	67-71
3337803-4	1988	Protein 4.1 increased the permeability of negatively charged PS, but not PC, liposomes, measured as the increase in fluorescence when encapsulated 1-aminonaphthalene-3,6,8-trisulfonic acid (ANTS) and p-xylenebispyridinium bromide (DPX) or carboxyfluorescein were released into the medium.	6-carboxyfluorescein	239-257	erythrocyte membrane protein band 4.1	Homo sapiens	0-11
2924913-3	1989	The effects of Pep 5 and nisin on neutral membranes, as studied by membrane fluidity, phase transition points and carboxyfluorescein efflux, were small compared to melittin.	6-carboxyfluorescein	114-132	VPS11 core subunit of CORVET and HOPS complexes	Homo sapiens	15-20
3191124-3	1988	Using this technique, we have characterized complement-mediated release of carboxyfluorescein from large unilamellar vesicles and have found that C5-8 complexes mediate a graded release of dye while C5-9 complexes cause an all-or-none release.	6-carboxyfluorescein	75-93	complement C5	Homo sapiens	146-150
3209355-4	1988	Furthermore, PA1-14 induced the moderate leakage of carboxyfluorescein from phospholipid vesicles.	6-carboxyfluorescein	52-70	PAXIP1 associated glutamate rich protein 1	Homo sapiens	13-19
3130102-9	1988	Only the best penetrating mutant, viz., porcine phospholipase A2 having a palmitoyl moiety at Lys116, was able to cause complete leakage of 6-carboxyfluorescein entrapped in small unilamellar vesicles of egg lecithin under nonhydrolytic conditions.	6-carboxyfluorescein	140-160	LOC104974671	Bos taurus	48-64
2624855-4	1989	Here we report that sperm pHi, measured with the fluorescent pH probe carboxyfluorescein, increases by approximately 0.4 units in response to either of these motility-initiating manipulations.	6-carboxyfluorescein	70-88	glucose-6-phosphate isomerase	Bos taurus	26-29
2848827-3	1988	Accordingly, thrombin elicits a sustained alkalinization in 6-carboxyfluorescein-loaded endothelial cells, that is abolished in either Na+-free or 5-(N-ethyl-N-isopropyl)amiloride-containing medium.	6-carboxyfluorescein	60-80	coagulation factor II, thrombin	Homo sapiens	13-21
2838082-1	1988	The interaction between cytochrome c and its heme-free precursor apocytochrome c and chemically prepared fragments of these basic proteins with phosphatidylserine containing model membrane systems was studied by differential scanning calorimetry and carboxyfluorescein release experiments.	6-carboxyfluorescein	250-268	cytochrome c, somatic	Homo sapiens	24-36
3436953-6	1987	The ability of SEP1-15 and SEP1-20 to induce leakage of carboxyfluorescein from the inside of dipalmitoyl-DL-alpha-phosphatidylcholine (DPPC) or DPPC-dipalmitoyl-DL-alpha-phosphatidylglycerol (3:1) vesicles was much greater than that of other peptides.	6-carboxyfluorescein	56-74	septin 1	Homo sapiens	15-19
3443107-5	1987	When targeted liposomes that contained carboxyfluorescein at a self-quenched concentration were directed against H-2K molecules, the cells became highly fluorescent after 30 min: a consequence of carboxyfluorescein release from the liposomes.	6-carboxyfluorescein	39-57	histocompatibility 2, K1, K region	Mus musculus	113-117
3443107-5	1987	When targeted liposomes that contained carboxyfluorescein at a self-quenched concentration were directed against H-2K molecules, the cells became highly fluorescent after 30 min: a consequence of carboxyfluorescein release from the liposomes.	6-carboxyfluorescein	196-214	histocompatibility 2, K1, K region	Mus musculus	113-117
3676318-1	1987	The results shown in this paper indicate that the permeability properties of egg yolk phosphatidylcholine sonicated vesicles as detected by the leakage of carboxy fluorescein changes according to the Ca2+ content.	6-carboxyfluorescein	155-174	carbonic anhydrase 2	Homo sapiens	200-203
3436953-6	1987	The ability of SEP1-15 and SEP1-20 to induce leakage of carboxyfluorescein from the inside of dipalmitoyl-DL-alpha-phosphatidylcholine (DPPC) or DPPC-dipalmitoyl-DL-alpha-phosphatidylglycerol (3:1) vesicles was much greater than that of other peptides.	6-carboxyfluorescein	56-74	septin 1	Homo sapiens	27-34
2985737-1	1985	The intracellular pH (pHi) of isolated human peripheral blood neutrophils was measured from the fluorescence of 6-carboxyfluorescein (6-CF) and from the equilibrium distribution of [14C]5,5-dimethyloxazolidine -2,4-dione (DMO).	6-carboxyfluorescein	112-132	glucose-6-phosphate isomerase	Homo sapiens	22-25
2871045-6	1986	pHi was estimated fluorometrically using the entrapped intracytoplasmic pH indicator, 6-carboxyfluorescein.	6-carboxyfluorescein	86-106	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-3
3964650-5	1986	Addition of LpL to sonicated C14-ether-PC vesicles containing entrapped carboxyfluorescein caused the release of less than 15% of the vesicle contents in 20 min, indicating that the enzyme did not disrupt the structure of the lipid.	6-carboxyfluorescein	72-90	lipoprotein lipase	Homo sapiens	12-15
3723841-4	1986	CRP antigen is coupled to the carboxyfluorescein entrapped multilamellar liposomes by using N-hydroxysuccinimidyl 3-(2-pyridyldithio) propionate and dithiothreitol, and a specific lysis of liposomes is achieved upon the addition of anti-CRP antibody in the presence of complement.	6-carboxyfluorescein	30-48	C-reactive protein	Homo sapiens	0-3
3723841-4	1986	CRP antigen is coupled to the carboxyfluorescein entrapped multilamellar liposomes by using N-hydroxysuccinimidyl 3-(2-pyridyldithio) propionate and dithiothreitol, and a specific lysis of liposomes is achieved upon the addition of anti-CRP antibody in the presence of complement.	6-carboxyfluorescein	30-48	C-reactive protein	Homo sapiens	237-240
3864381-4	1985	Measurements with carboxyfluorescein reveal that the two agents cause equal decreases of intracellular pH (pHi), an effect that is dependent on the presence of extracellular Na (Na replacement also decreases pHi).	6-carboxyfluorescein	18-36	glucose-6-phosphate isomerase	Oryctolagus cuniculus	107-110
2996597-8	1985	pretreatment of virions with increasing concentrations of three different proteolytic enzymes (trypsin, chymotrypsin and proteinase) inhibited the virus" ability to cause release of carboxyfluorescein from negatively charged liposomes.	6-carboxyfluorescein	182-200	endogenous retrovirus group K member 25	Homo sapiens	121-131
2439551-1	1987	The effects of aging on the intercellular transfer of the low molecular weight fluorescent dye 5,6-carboxyfluorescein was studied in subfields fascia dentata, CA1, and CA3 of rat hippocampal slices maintained in vitro.	6-carboxyfluorescein	95-117	carbonic anhydrase 3	Rattus norvegicus	168-171
3734628-6	1986	Carboxyfluorescein and [3H]dextran entrapment studies show the DMPC-apoB 4:1 (w/w) complex to encapsulate an aqueous volume of 0.17 microliter/mumol of DMPC.	6-carboxyfluorescein	0-18	apolipoprotein B	Homo sapiens	68-72
2418058-5	1986	pHi was estimated fluorometrically using the entrapped intracytoplasmic pH indicator, 6-carboxyfluorescein.	6-carboxyfluorescein	86-106	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-3
3932344-5	1985	Apo-A-I-induced release of vesicle contents was monitored by the relief of self-quenching of vesicle-encapsulated carboxyfluorescein.	6-carboxyfluorescein	114-132	apolipoprotein A1	Homo sapiens	0-5
2985737-1	1985	The intracellular pH (pHi) of isolated human peripheral blood neutrophils was measured from the fluorescence of 6-carboxyfluorescein (6-CF) and from the equilibrium distribution of [14C]5,5-dimethyloxazolidine -2,4-dione (DMO).	6-carboxyfluorescein	134-138	glucose-6-phosphate isomerase	Homo sapiens	22-25
3994992-0	1985	Incorporation of 6-carboxyfluorescein into myosin subfragment 1.	6-carboxyfluorescein	17-37	myosin heavy chain 14	Homo sapiens	43-49
6208335-1	1984	The capacity of myelin basic protein or of poly-L-lysine to promote leakage of carboxyfluorescein from vesicles or the aggregation of vesicles was studied.	6-carboxyfluorescein	79-97	myelin basic protein	Bos taurus	16-36
4032457-6	1985	At cell membrane resting potential, the kj"s ranged 3.8-9.2 X 10(-3) sec-1 for the small carboxyfluorescein (mol wt 376) to about 0.4 X 10(-3) sec-1 for a large fluorescein-labeled sugar (mol wt 2327).	6-carboxyfluorescein	89-107	secretory blood group 1, pseudogene	Homo sapiens	69-74
4032457-6	1985	At cell membrane resting potential, the kj"s ranged 3.8-9.2 X 10(-3) sec-1 for the small carboxyfluorescein (mol wt 376) to about 0.4 X 10(-3) sec-1 for a large fluorescein-labeled sugar (mol wt 2327).	6-carboxyfluorescein	89-107	secretory blood group 1, pseudogene	Homo sapiens	143-148
6208335-8	1984	In general, the effects of the myelin basic protein on either carboxyfluorescein release or vesicle aggregation were similar to, although somewhat greater than, that of poly-L-lysine.	6-carboxyfluorescein	62-80	myelin basic protein	Bos taurus	31-51
6548158-3	1984	Porcine pancreatic phospholipase A2 and bovine milk lipoprotein lipase catalyze the hydrolysis of the phosphatidylcholine resulting in the release of the encapsulated dye and a large increase in 6-carboxyfluorescein fluorescence.	6-carboxyfluorescein	195-215	LOC104974671	Bos taurus	19-35
6548158-3	1984	Porcine pancreatic phospholipase A2 and bovine milk lipoprotein lipase catalyze the hydrolysis of the phosphatidylcholine resulting in the release of the encapsulated dye and a large increase in 6-carboxyfluorescein fluorescence.	6-carboxyfluorescein	195-215	lipoprotein lipase	Bos taurus	52-70
6202299-1	1984	Black lipid membranes and liposomes loaded with Ca2+ or 5,6-carboxyfluorescein were used for exploring the mechanism of action of insulin-releasing sulfonylureas.	6-carboxyfluorescein	56-78	insulin	Homo sapiens	130-137
6498219-9	1984	On the basis of patterns of quenched carboxyfluorescein, 111In and 125I-clearance from the circulation, of 99mTc levels in the blood and of values of 111In in the liver and spleen, it appeared that IgG1-bearing liposomes were capable of binding to their target cells in the vasculature.	6-carboxyfluorescein	37-55	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	198-202
6087813-1	1984	The cytoplasmic pH (pHi) of human blood neutrophils was measured using trapped carboxyfluorescein derivatives.	6-carboxyfluorescein	79-97	glucose-6-phosphate isomerase	Homo sapiens	20-23
6541804-4	1984	Liposome-incorporated monoclonal antibodies directed towards carcinoembryonic antigen (CEA) provided increased transfer of the fluorescent dye carboxyfluorescein from liposomes into cultured human colon carcinoma cells.	6-carboxyfluorescein	143-161	CEA cell adhesion molecule 3	Homo sapiens	61-85
6541804-4	1984	Liposome-incorporated monoclonal antibodies directed towards carcinoembryonic antigen (CEA) provided increased transfer of the fluorescent dye carboxyfluorescein from liposomes into cultured human colon carcinoma cells.	6-carboxyfluorescein	143-161	CEA cell adhesion molecule 3	Homo sapiens	87-90
6689106-2	1983	Glycyrrhizin was found to inhibit the PLA2-induced carboxyfluorescein (CF) release from D,L-dipalmitoyl phosphatidylcholine (DPPC) liposomes.	6-carboxyfluorescein	51-69	phospholipase A2 group IB	Homo sapiens	38-42
6689106-2	1983	Glycyrrhizin was found to inhibit the PLA2-induced carboxyfluorescein (CF) release from D,L-dipalmitoyl phosphatidylcholine (DPPC) liposomes.	6-carboxyfluorescein	71-73	phospholipase A2 group IB	Homo sapiens	38-42
6199195-0	1983	Endocytosis of HLA and H-2 molecules on transformed murine cells measured by fluorescence dequenching of liposome-encapsulated carboxyfluorescein.	6-carboxyfluorescein	127-145	histocompatibility-2, MHC	Mus musculus	23-26
32910949-4	2021	Using HEK293 cells stably transfected with OAT1 and OAT3, 25 drug metabolites and their corresponding parent drugs were screened for inhibitory effects on OAT1- and OAT3-mediated 6-carboxyfluorescein uptake at a screening concentration of 200 muM for all but 3 compounds.	6-carboxyfluorescein	179-199	solute carrier family 22 member 6	Homo sapiens	155-159
6803776-2	1981	Affinity chromatography-purified and non-purified rabbit immunoglobulin G (IgG) raised against human immunoglobulin M (IgM) or kappa chain was incorporated into carboxyfluorescein-containing small unilamellar liposomes composed of egg phosphatidylcholine, cholesterol and phosphatidic acid (molar proportions 7:7:1).	6-carboxyfluorescein	161-179	immunoglobulin heavy variable V1-62	Mus musculus	75-78
33922514-3	2021	In this work, we found that fluorescence intensity of 6-carboxyfluorescein(FAM)-labeled aptamer (FAM-aptamer) could be remarkably amplified by 3-(N-morpholino)propane sulfonic acid (MOPS), then fell proportionally as Cd2+ concentration introduced.	6-carboxyfluorescein	54-74	CD2 molecule	Homo sapiens	217-220
33965427-0	2021	Development of a fluorescence-based assay for screening of urate transporter 1 inhibitors using 6-carboxyfluorescein.	6-carboxyfluorescein	96-116	solute carrier family 22 member 12	Homo sapiens	59-78
33965427-4	2021	Herein, we report the development of a non-radioactive cell-based method for the screening of URAT1 inhibitors using the human embryonic kidney 293T cells stably expressing human URAT1, and 6-carboxyfluorescein (6-CFL) as a substrate.	6-carboxyfluorescein	190-210	solute carrier family 22 member 12	Homo sapiens	94-99
33965427-4	2021	Herein, we report the development of a non-radioactive cell-based method for the screening of URAT1 inhibitors using the human embryonic kidney 293T cells stably expressing human URAT1, and 6-carboxyfluorescein (6-CFL) as a substrate.	6-carboxyfluorescein	212-217	solute carrier family 22 member 12	Homo sapiens	94-99
33732788-0	2021	Carboxyfluorescein Dye Uptake to Measure Connexin-mediated Hemichannel Activity in Cultured Cells.	6-carboxyfluorescein	0-18	LOC100128922	Homo sapiens	41-49
33183433-7	2021	Carboxy fluorescein and rhodamine fluorescein are used to double label IgG/PLGA/Dt386 and AFP/PLGA/Dt386 nanospheres, respectively, the entry of nanospheres into HepG2 cells are observed at 3 h and 12 h. The effect of AFP/PLGA/Dt386 nanospheres on the migration of HepG2 cells is examined by wounding healing assay.	6-carboxyfluorescein	0-19	alpha fetoprotein	Homo sapiens	90-93
33183433-7	2021	Carboxy fluorescein and rhodamine fluorescein are used to double label IgG/PLGA/Dt386 and AFP/PLGA/Dt386 nanospheres, respectively, the entry of nanospheres into HepG2 cells are observed at 3 h and 12 h. The effect of AFP/PLGA/Dt386 nanospheres on the migration of HepG2 cells is examined by wounding healing assay.	6-carboxyfluorescein	0-19	alpha fetoprotein	Homo sapiens	218-221
32910949-4	2021	Using HEK293 cells stably transfected with OAT1 and OAT3, 25 drug metabolites and their corresponding parent drugs were screened for inhibitory effects on OAT1- and OAT3-mediated 6-carboxyfluorescein uptake at a screening concentration of 200 muM for all but 3 compounds.	6-carboxyfluorescein	179-199	solute carrier family 22 member 8	Homo sapiens	165-169
33015009-7	2020	MRP1 activity was assessed by bidirectional transport and efflux experiments using the MRP1 substrate, 5(6)-carboxyfluorescein [CF; formed intracellularly from 5(6)-carboxyfluorescein-diacetate (CFDA)] in AT1-like and NCI-H441 cell monolayers.	6-carboxyfluorescein	103-126	ATP binding cassette subfamily C member 1	Homo sapiens	0-4
33015009-7	2020	MRP1 activity was assessed by bidirectional transport and efflux experiments using the MRP1 substrate, 5(6)-carboxyfluorescein [CF; formed intracellularly from 5(6)-carboxyfluorescein-diacetate (CFDA)] in AT1-like and NCI-H441 cell monolayers.	6-carboxyfluorescein	103-126	ATP binding cassette subfamily C member 1	Homo sapiens	87-91
33015009-7	2020	MRP1 activity was assessed by bidirectional transport and efflux experiments using the MRP1 substrate, 5(6)-carboxyfluorescein [CF; formed intracellularly from 5(6)-carboxyfluorescein-diacetate (CFDA)] in AT1-like and NCI-H441 cell monolayers.	6-carboxyfluorescein	128-130	ATP binding cassette subfamily C member 1	Homo sapiens	0-4
33015009-7	2020	MRP1 activity was assessed by bidirectional transport and efflux experiments using the MRP1 substrate, 5(6)-carboxyfluorescein [CF; formed intracellularly from 5(6)-carboxyfluorescein-diacetate (CFDA)] in AT1-like and NCI-H441 cell monolayers.	6-carboxyfluorescein	128-130	ATP binding cassette subfamily C member 1	Homo sapiens	87-91
32033633-5	2020	A hexachloro-6-carboxyfluorescein-labeled RPP30 probe was used as an internal control and a 6-carboxyfluorescein-labeled SRY probe as a target.	6-carboxyfluorescein	2-33	ribonuclease P/MRP subunit p30	Homo sapiens	42-47
32305339-2	2020	The assay is based on TaqMan-MGB technology, consisting of two primers and one probe labeled with the reporter dye 6-carboxyfluorescein that binds selectively to the sigma B-protein gene of MDRV.	6-carboxyfluorescein	115-135	tyrosinase related protein 1	Homo sapiens	172-181
32488542-1	2020	Using 6-carboxyfluorescein (FAM) and tetramethyl rhodamine (TAMRA) as fluorescent signals a ratiometric fluorescent three-dimensional (3D) DNA walker based on a catalytic hairpin assembly (CHA) reaction for microRNA-122 detection was constructed.	6-carboxyfluorescein	6-26	microRNA 122	Homo sapiens	207-219
32033633-5	2020	A hexachloro-6-carboxyfluorescein-labeled RPP30 probe was used as an internal control and a 6-carboxyfluorescein-labeled SRY probe as a target.	6-carboxyfluorescein	13-33	ribonuclease P/MRP subunit p30	Homo sapiens	42-47
30959978-4	2019	SLG-30 increased the intestinal absorption of 5(6)-carboxyfluorescein (CF) to a greater level than the typical absorption enhancers, including sodium glycocholate and sodium laurate, as evaluated by an in situ closed-loop method.	6-carboxyfluorescein	46-69	sialic acid binding Ig like lectin 12	Homo sapiens	0-3
31617353-3	2019	The experimental results reveal that Ru 2 and Ru 3 can form a P-DNA@Ru sensing platform with the introduction of carboxyfluorescein (FAM)/5-carboxy-X-rhodamine (ROX) tagged single-chained probe DNA (P-DNA), to realize the discernment of the complementary P-DNA sequence of miR-221/222, giving the limit of detection (LOD) at the nanomolar level with a specific and speedy response.	6-carboxyfluorescein	113-131	doublecortin domain containing 2	Homo sapiens	37-50
31617353-3	2019	The experimental results reveal that Ru 2 and Ru 3 can form a P-DNA@Ru sensing platform with the introduction of carboxyfluorescein (FAM)/5-carboxy-X-rhodamine (ROX) tagged single-chained probe DNA (P-DNA), to realize the discernment of the complementary P-DNA sequence of miR-221/222, giving the limit of detection (LOD) at the nanomolar level with a specific and speedy response.	6-carboxyfluorescein	113-131	microRNA 221	Homo sapiens	273-280
31357325-8	2019	In cycle I, the tDNA1 hybridizes with the hairpin DNA2, which leads the hairpin structure of DNA2 opened and the fluorescence signal of 6-carboxy-fluorescein (FAM) labeled on hairpin DNA2 turned on.	6-carboxyfluorescein	136-157	DNA replication helicase/nuclease 2	Homo sapiens	50-54
31171163-9	2019	Compared with 6-carboxyfluorescein (6-FAM) labeled aptamer W3, the TMAP was demonstrated to have a much stronger fluorescence signal on the target cells, realizing a 4-fold increase in signal-to-background ratio (SBR).	6-carboxyfluorescein	14-34	cytoskeleton associated protein 2	Homo sapiens	67-71
31171163-9	2019	Compared with 6-carboxyfluorescein (6-FAM) labeled aptamer W3, the TMAP was demonstrated to have a much stronger fluorescence signal on the target cells, realizing a 4-fold increase in signal-to-background ratio (SBR).	6-carboxyfluorescein	36-41	cytoskeleton associated protein 2	Homo sapiens	67-71
30959978-4	2019	SLG-30 increased the intestinal absorption of 5(6)-carboxyfluorescein (CF) to a greater level than the typical absorption enhancers, including sodium glycocholate and sodium laurate, as evaluated by an in situ closed-loop method.	6-carboxyfluorescein	71-73	sialic acid binding Ig like lectin 12	Homo sapiens	0-3
30367880-5	2019	With the increase of PSA concentration, the strength of the red light emitted from Texas Red dropped exponentially, whereas with the increase of VEGF concentration, the green light emitted from 6-FAM was enhanced.	6-carboxyfluorescein	194-199	kallikrein related peptidase 3	Homo sapiens	21-24
30833583-5	2019	Anti-miR and scramble PNAs were synthesized and linked to carboxyfluorescein or DOTA.	6-carboxyfluorescein	58-76	membrane associated ring-CH-type finger 8	Homo sapiens	5-8
30367880-5	2019	With the increase of PSA concentration, the strength of the red light emitted from Texas Red dropped exponentially, whereas with the increase of VEGF concentration, the green light emitted from 6-FAM was enhanced.	6-carboxyfluorescein	194-199	vascular endothelial growth factor A	Homo sapiens	145-149
29594715-10	2018	Graphical abstract Schematic of a dual-channel photoluminescence nanoprobe for the determination of microRNA-21 (miR-21) by monitoring the microRNA-triggered enhancement of the fluorescence resonance energy transfer (FRET) efficiency between MoS2 QDs and carboxyfluorescein-labeled molecular beacons.	6-carboxyfluorescein	255-273	microRNA 21	Homo sapiens	100-111
29943526-4	2018	A CCl4-induced damage mechanism involves the compromise of membrane functions, resulting in accumulation of processed 6-carboxyfluorescein molecules.	6-carboxyfluorescein	118-138	chemokine (C-C motif) ligand 4	Mus musculus	2-6
30310592-5	2018	Each ODN on the MBs can be effectively elongated by TdT in a template-free manner to produce a long poly(T) tail, which will then bind to many 6-carboxyfluorescein (FAM)-labeled poly(A)25.	6-carboxyfluorescein	143-163	DNA nucleotidylexotransferase	Homo sapiens	52-55
30014163-9	2018	Graphical abstract Hybridization of aptamer and carboxyfluorescein labeled complementary DNA is combined with magnetic separation for detection of as low as 1 cfu mL-1 Pseudomonas aeruginosa.	6-carboxyfluorescein	48-66	L1 cell adhesion molecule	Mus musculus	163-167
28322801-3	2018	The popular fluorescent marker 5(6)-carboxyfluorescein appeared highly susceptible to cyt c-mediated peroxidative destruction and therefore unsuitable for the leakage assay with cyt c/H2O2.	6-carboxyfluorescein	31-54	cytochrome c, somatic	Homo sapiens	86-91
29594715-10	2018	Graphical abstract Schematic of a dual-channel photoluminescence nanoprobe for the determination of microRNA-21 (miR-21) by monitoring the microRNA-triggered enhancement of the fluorescence resonance energy transfer (FRET) efficiency between MoS2 QDs and carboxyfluorescein-labeled molecular beacons.	6-carboxyfluorescein	255-273	microRNA 21	Homo sapiens	113-119
28744858-3	2017	The uptake of 6-carboxyfluorescein by HEK293 cells expressing rOAT1 or rOAT3 was not affected by d-malate and l-malate.	6-carboxyfluorescein	14-34	solute carrier family 22 member 6	Rattus norvegicus	62-67
29310291-2	2018	It was found that all complexes can form sensing platform for the detection of the complementary target miR-185 through the introduction of carboxyfluorescein (FAM) labeled single stranded DNA (P-DNA), giving the detection limits of 0.42nM for Ru 1, 0.28nM for Ru 2, 0.32nM for Ru 3, 0.85nM for Ru 4, all with instantaneous detection time in 1min.	6-carboxyfluorescein	140-158	microRNA 185	Homo sapiens	104-111
29310291-2	2018	It was found that all complexes can form sensing platform for the detection of the complementary target miR-185 through the introduction of carboxyfluorescein (FAM) labeled single stranded DNA (P-DNA), giving the detection limits of 0.42nM for Ru 1, 0.28nM for Ru 2, 0.32nM for Ru 3, 0.85nM for Ru 4, all with instantaneous detection time in 1min.	6-carboxyfluorescein	140-158	Scm like with four mbt domains 1	Homo sapiens	244-248
29310291-2	2018	It was found that all complexes can form sensing platform for the detection of the complementary target miR-185 through the introduction of carboxyfluorescein (FAM) labeled single stranded DNA (P-DNA), giving the detection limits of 0.42nM for Ru 1, 0.28nM for Ru 2, 0.32nM for Ru 3, 0.85nM for Ru 4, all with instantaneous detection time in 1min.	6-carboxyfluorescein	140-158	doublecortin domain containing 2	Homo sapiens	261-265
29587265-12	2018	Acute (48h) and chronic (7day) challenge with TGFbeta1 produced a carbenoxolone (200microM)-sensitive increase in carboxyfluorescein loading, matched by an increase in ATP release from 0.29+-0.06muM in control to 1.99+-0.47muM after 48hr incubation with TGFbeta1 (10ng/ml; P<0.05, n=3).	6-carboxyfluorescein	114-132	transforming growth factor beta 1	Homo sapiens	46-54
29273507-6	2018	The interaction between OAT1 and d-luc was verified using 6-carboxyfluorescein, a typical substrate of OAT1, which showed that d-luc inhibited the uptake of 6-carboxyfluorescein mediated by OAT1.	6-carboxyfluorescein	58-78	solute carrier family 22 member 6	Homo sapiens	24-28
29273507-6	2018	The interaction between OAT1 and d-luc was verified using 6-carboxyfluorescein, a typical substrate of OAT1, which showed that d-luc inhibited the uptake of 6-carboxyfluorescein mediated by OAT1.	6-carboxyfluorescein	58-78	solute carrier family 22 member 6	Homo sapiens	103-107
29273507-6	2018	The interaction between OAT1 and d-luc was verified using 6-carboxyfluorescein, a typical substrate of OAT1, which showed that d-luc inhibited the uptake of 6-carboxyfluorescein mediated by OAT1.	6-carboxyfluorescein	58-78	solute carrier family 22 member 6	Homo sapiens	103-107
29273507-6	2018	The interaction between OAT1 and d-luc was verified using 6-carboxyfluorescein, a typical substrate of OAT1, which showed that d-luc inhibited the uptake of 6-carboxyfluorescein mediated by OAT1.	6-carboxyfluorescein	157-177	solute carrier family 22 member 6	Homo sapiens	24-28
29273507-6	2018	The interaction between OAT1 and d-luc was verified using 6-carboxyfluorescein, a typical substrate of OAT1, which showed that d-luc inhibited the uptake of 6-carboxyfluorescein mediated by OAT1.	6-carboxyfluorescein	157-177	solute carrier family 22 member 6	Homo sapiens	103-107
29273507-6	2018	The interaction between OAT1 and d-luc was verified using 6-carboxyfluorescein, a typical substrate of OAT1, which showed that d-luc inhibited the uptake of 6-carboxyfluorescein mediated by OAT1.	6-carboxyfluorescein	157-177	solute carrier family 22 member 6	Homo sapiens	103-107
28744858-3	2017	The uptake of 6-carboxyfluorescein by HEK293 cells expressing rOAT1 or rOAT3 was not affected by d-malate and l-malate.	6-carboxyfluorescein	14-34	solute carrier family 22 member 8	Rattus norvegicus	71-76
28594110-4	2017	Second, the rapid binding kinetics between the thrombin and 6-carboxyfluorescein labeled G-quadruplex aptamer was measured.	6-carboxyfluorescein	60-80	coagulation factor II, thrombin	Homo sapiens	47-55
28961159-9	2017	We demonstrated the interaction of carbamazepine and valproate with ABCC2 with ATPase and 5,6-carboxyfluorescein inhibition assays.	6-carboxyfluorescein	92-112	ATP binding cassette subfamily C member 2	Homo sapiens	68-73
28479361-1	2017	To understand interaction of drugs with the prostaglandin transporter OATP2A1/SLCO2A1 that regulates disposition of prostaglandins, we explored the impact of 636 drugs in an FDA-approved drug library on 6-carboxyfluorescein (6-CF) uptake by OATP2A1-expressing HEK293 cells (HEK/2A1).	6-carboxyfluorescein	203-223	solute carrier organic anion transporter family member 2A1	Homo sapiens	70-77
27741503-4	2017	Two hairpin DNA probes of TSDR are ingeniously designed, including biotinylated hairpin DNA1 (H1) and carboxyfluorescein (FAM)-labeled hairpin DNA2 (F-H2).	6-carboxyfluorescein	102-120	DNA replication helicase/nuclease 2	Homo sapiens	143-147
27630987-6	2016	The intracellular pH (pHi) measured using the fluorescent ratio dye 2",7"-bis(2-carboxyethyl)-5(6)-155 carboxyfluorescein (BCECF) revealed expected differences between normal and cancer cells (low and high, respectively), and a mixed distribution in the MINO cells, with a subset of cells in the MINO having an increased rate of acidification when proton efflux was inhibited.	6-carboxyfluorescein	103-121	glucose-6-phosphate isomerase	Homo sapiens	18-20
27670095-6	2016	Using this information, we further investigated the cellular uptake of carboxyfluorescein-labelled BBN and BBN(6-14) peptides by flow cytometry and confocal microscopy using cell lines that express GRPR (Caco-2, HeLa, PC-3).	6-carboxyfluorescein	71-89	gastrin releasing peptide	Homo sapiens	99-102
27467266-3	2016	We evaluated the effect of 72 uremic solutes on organic anion transporter 1 and 3 (OAT1 and OAT3) using a fluorescent probe substrate, 6-carboxyfluorescein.	6-carboxyfluorescein	135-155	solute carrier family 22 member 6	Homo sapiens	48-81
27467266-3	2016	We evaluated the effect of 72 uremic solutes on organic anion transporter 1 and 3 (OAT1 and OAT3) using a fluorescent probe substrate, 6-carboxyfluorescein.	6-carboxyfluorescein	135-155	solute carrier family 22 member 6	Homo sapiens	83-87
27467266-3	2016	We evaluated the effect of 72 uremic solutes on organic anion transporter 1 and 3 (OAT1 and OAT3) using a fluorescent probe substrate, 6-carboxyfluorescein.	6-carboxyfluorescein	135-155	solute carrier family 22 member 8	Homo sapiens	92-96
27630987-6	2016	The intracellular pH (pHi) measured using the fluorescent ratio dye 2",7"-bis(2-carboxyethyl)-5(6)-155 carboxyfluorescein (BCECF) revealed expected differences between normal and cancer cells (low and high, respectively), and a mixed distribution in the MINO cells, with a subset of cells in the MINO having an increased rate of acidification when proton efflux was inhibited.	6-carboxyfluorescein	103-121	glucose-6-phosphate isomerase	Homo sapiens	22-25
26079506-4	2015	In this study, we analyzed the expression of CD69 and NKG2D by T lymphocytes from the peripheral blood of twenty-five healthy subjects by multi-parametric flow cytometry analysis, and their suppressive activity by an assay of inhibition of lymphocyte activation (CD40L expression) and proliferation (carboxyfluorescein partition assay).	6-carboxyfluorescein	300-318	CD69 molecule	Homo sapiens	45-49
26670641-5	2016	With the same methodology, the Fab fragments of anti-TNFalpha and anti-Her2 were derivatized exclusively at their C-terminal ends with PEG and the fluorescent dye carboxyfluorescein in the case of anti-TNFalpha or with the cytotoxic payload DM1 in the case of anti-Her2, to form a homogeneous antibody-drug conjugate (ADC).	6-carboxyfluorescein	163-181	FA complementation group B	Homo sapiens	31-34
26670641-5	2016	With the same methodology, the Fab fragments of anti-TNFalpha and anti-Her2 were derivatized exclusively at their C-terminal ends with PEG and the fluorescent dye carboxyfluorescein in the case of anti-TNFalpha or with the cytotoxic payload DM1 in the case of anti-Her2, to form a homogeneous antibody-drug conjugate (ADC).	6-carboxyfluorescein	163-181	tumor necrosis factor	Homo sapiens	53-61
26670641-5	2016	With the same methodology, the Fab fragments of anti-TNFalpha and anti-Her2 were derivatized exclusively at their C-terminal ends with PEG and the fluorescent dye carboxyfluorescein in the case of anti-TNFalpha or with the cytotoxic payload DM1 in the case of anti-Her2, to form a homogeneous antibody-drug conjugate (ADC).	6-carboxyfluorescein	163-181	erb-b2 receptor tyrosine kinase 2	Homo sapiens	71-75
26670641-5	2016	With the same methodology, the Fab fragments of anti-TNFalpha and anti-Her2 were derivatized exclusively at their C-terminal ends with PEG and the fluorescent dye carboxyfluorescein in the case of anti-TNFalpha or with the cytotoxic payload DM1 in the case of anti-Her2, to form a homogeneous antibody-drug conjugate (ADC).	6-carboxyfluorescein	163-181	immunoglobulin heavy diversity 1-7	Homo sapiens	241-244
26670641-5	2016	With the same methodology, the Fab fragments of anti-TNFalpha and anti-Her2 were derivatized exclusively at their C-terminal ends with PEG and the fluorescent dye carboxyfluorescein in the case of anti-TNFalpha or with the cytotoxic payload DM1 in the case of anti-Her2, to form a homogeneous antibody-drug conjugate (ADC).	6-carboxyfluorescein	163-181	erb-b2 receptor tyrosine kinase 2	Homo sapiens	265-269
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein	88-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	9-13
25894334-4	2015	METHODS: The three-dimensional Bet v 1 (Bv1-Protein) and the T cell epitope peptide of Bet v 1 (Bv1-Peptide) were labelled with 5,6-Carboxyfluorescein (FAM) and their uptake was investigated in lung cells and cells of the nasal associated lymphoid tissue from naive and sensitised BALB/c mice.	6-carboxyfluorescein	128-150	endogenous ecotropic MuLV 2	Mus musculus	40-43
25894334-4	2015	METHODS: The three-dimensional Bet v 1 (Bv1-Protein) and the T cell epitope peptide of Bet v 1 (Bv1-Peptide) were labelled with 5,6-Carboxyfluorescein (FAM) and their uptake was investigated in lung cells and cells of the nasal associated lymphoid tissue from naive and sensitised BALB/c mice.	6-carboxyfluorescein	128-150	endogenous ecotropic MuLV 2	Mus musculus	96-99
25485477-2	2015	Cytochrome c/cardiolipin peroxidase activity was found here to cause leakage of carboxyfluorescein, sulforhodamine B and 3-kDa (but not 10-kDa) fluorescent dextran from liposomes.	6-carboxyfluorescein	80-98	LOC104968582	Bos taurus	0-12
25480791-4	2015	NHE3 activity was measured with 2",7"-bis(carboxyethyl)-S-(and 6)carboxyfluorescein acetoxy methylester/fluorometry.	6-carboxyfluorescein	65-83	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	0-4
24973540-4	2014	A chemiluminescent biosensor, developed using the different properties of G-rich DNA aptamer-conjugated 6-FAM in the absence and presence of PSA in guanine chemiluminescence reaction, was able to quantify trace levels of PSA in human serum within 30 min without time-consuming and complicated procedures (e.g., multiple incubation and washings) required for conventional immunoassays operated with expensive and intractable antibodies.	6-carboxyfluorescein	104-109	kallikrein related peptidase 3	Homo sapiens	141-144
24973540-4	2014	A chemiluminescent biosensor, developed using the different properties of G-rich DNA aptamer-conjugated 6-FAM in the absence and presence of PSA in guanine chemiluminescence reaction, was able to quantify trace levels of PSA in human serum within 30 min without time-consuming and complicated procedures (e.g., multiple incubation and washings) required for conventional immunoassays operated with expensive and intractable antibodies.	6-carboxyfluorescein	104-109	kallikrein related peptidase 3	Homo sapiens	221-224
24973540-1	2014	Using guanine (G)-rich DNA aptamer-conjugated 6-carboxyfluorescein (6-FAM) capable of rapidly capturing prostate specific antigen (PSA) in human serum, cost-effective and simple biosensor with guanine chemiluminescence detection was developed for early diagnosis of prostate cancer.	6-carboxyfluorescein	46-66	kallikrein related peptidase 3	Homo sapiens	104-135
24973540-1	2014	Using guanine (G)-rich DNA aptamer-conjugated 6-carboxyfluorescein (6-FAM) capable of rapidly capturing prostate specific antigen (PSA) in human serum, cost-effective and simple biosensor with guanine chemiluminescence detection was developed for early diagnosis of prostate cancer.	6-carboxyfluorescein	68-73	kallikrein related peptidase 3	Homo sapiens	104-135
24973540-3	2014	However, G-rich DNA aptamer-conjugated 6-FAM bound with PSA cannot emit light because PSA acts as a strong interference in CRET between 6-FAM and high-energy intermediate formed from the reaction of 3,4,5-trimethoxylphenylglyoxal (TMPG) and guanine of G-rich DNA aptamer.	6-carboxyfluorescein	39-44	kallikrein related peptidase 3	Homo sapiens	56-59
24973540-3	2014	However, G-rich DNA aptamer-conjugated 6-FAM bound with PSA cannot emit light because PSA acts as a strong interference in CRET between 6-FAM and high-energy intermediate formed from the reaction of 3,4,5-trimethoxylphenylglyoxal (TMPG) and guanine of G-rich DNA aptamer.	6-carboxyfluorescein	39-44	kallikrein related peptidase 3	Homo sapiens	86-89
24973540-3	2014	However, G-rich DNA aptamer-conjugated 6-FAM bound with PSA cannot emit light because PSA acts as a strong interference in CRET between 6-FAM and high-energy intermediate formed from the reaction of 3,4,5-trimethoxylphenylglyoxal (TMPG) and guanine of G-rich DNA aptamer.	6-carboxyfluorescein	136-141	kallikrein related peptidase 3	Homo sapiens	56-59
24973540-3	2014	However, G-rich DNA aptamer-conjugated 6-FAM bound with PSA cannot emit light because PSA acts as a strong interference in CRET between 6-FAM and high-energy intermediate formed from the reaction of 3,4,5-trimethoxylphenylglyoxal (TMPG) and guanine of G-rich DNA aptamer.	6-carboxyfluorescein	136-141	kallikrein related peptidase 3	Homo sapiens	86-89
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein	88-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
25262337-6	2014	Blocking IP3R with antagonists or silencing pan-IP3R expression with shRNA hindered the 6-carboxyfluorescein (6-CFDA) diffusion through GJs and desynchronized Ca2+ transients among confluent neonatal myocytes in culture, whereas stimulation of IP3R with IP3 ester or ATP exerted the opposite effect.	6-carboxyfluorescein	88-108	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	48-52
24530383-4	2014	CPC (100 muM) reduced the uptake of MPP(+) and metformin mediated by OCT2 in MDCK-hOCT2 cells to 60.8% and 33.6% of the control, CPC (500 muM) decreased the uptake of 6-carboxyfluorescein (6-CFL) and para-aminohippuric acid (PAH), substrates of OAT1, in MDCK-hOAT1 cells to 64.6% and 79.4% of the control.	6-carboxyfluorescein	167-187	solute carrier family 22 member 2	Rattus norvegicus	69-73
25165986-5	2014	METHODOLOGY/PRINCIPAL FINDINGS: The specificity of carboxy-fluorescein (CF-) labeled TPP (TPP) to Hsp70 was proven in an Hsp70 knockout mammary tumor cell system.	6-carboxyfluorescein	51-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	98-103
25165986-5	2014	METHODOLOGY/PRINCIPAL FINDINGS: The specificity of carboxy-fluorescein (CF-) labeled TPP (TPP) to Hsp70 was proven in an Hsp70 knockout mammary tumor cell system.	6-carboxyfluorescein	51-70	heat shock protein family A (Hsp70) member 4	Homo sapiens	121-126
24824856-2	2014	For this purpose, bovine serum albumin (BSA) was complexed with biotin (histologic studies), 5(6)-carboxyfluorescein, succinimidyl ester (FAM SE) (OI studies), and diethylenetriamine pentaacetic acid (DTPA) for chelating gallium 68 (PET studies).	6-carboxyfluorescein	93-116	albumin	Mus musculus	25-38
24249420-1	2014	Time-resolved fluorescence anisotropy spectroscopy was applied to study the interaction between a peptide truncated from the binding site of tumor suppressor p53 protein and the DNAs covalently labeled with 6-carboxyfluorescein (FAM) dye.	6-carboxyfluorescein	207-227	tumor protein p53	Homo sapiens	158-161
24161614-6	2014	When the substrate and C-2 oligonucleotides were labeled with a carboxyfluorescein (FAM) fluorophore and a 4-([4-(dimethylamino)phenyl]azo)benzoic acid (DABCYL) quencher, this SDR catalytic system exhibited a "turn-on" response for ATP.	6-carboxyfluorescein	64-82	complement C2	Homo sapiens	23-26
22219367-1	2012	A fluorescent molecular probe, 6-carboxy fluorescein, was used in conjunction with in situ fluorescence spectroscopy to facilitate real-time monitoring of degradation inducing reactive oxygen species within the polymer electrolyte membrane (PEM) of an operating PEM fuel cell.	6-carboxyfluorescein	31-52	mucin 1, cell surface associated	Homo sapiens	211-239
23689395-3	2013	Fluorescent compounds (fluorescein disodium salt and carboxyfluorescein) were loaded in the porous structure of the MSNs and entrapped in the silica matrix with the dendrimers of generations I through V by anchoring dendrimers on the MSN surface through disulfide bonds.	6-carboxyfluorescein	53-71	moesin	Homo sapiens	116-119
23586620-3	2013	The present study uses confocal microscopy to identify the localization of carboxyfluorescein-labeled amylin in RIN-5F cells.	6-carboxyfluorescein	75-93	islet amyloid polypeptide	Mus musculus	102-108
23576757-6	2013	Passive fluorescent markers such as carboxyfluorescein and a 10-kDa dextran polymer crossed the membrane simultaneously with cyt c, although larger dextrans did not.	6-carboxyfluorescein	36-54	cytochrome c, somatic	Homo sapiens	125-130
22905671-7	2012	In parallel experiments, release of carboxyfluorescein from liposomes prepared from bacterial lipids was determined fluorometrically (excitation 485/20 nm, emission 528/20 nm) in the presence of HBD-1, HBD-2 or Nisin.	6-carboxyfluorescein	36-54	defensin beta 4A	Homo sapiens	202-207
22847157-4	2012	Then, 2 probes specific for wild or mutation exons 19, 21 of EGFR were labeled with tetramethyl 6-carboxyrhodamine or 6-carboxyfluorescein hybridized, respectively, with their target amplicons, and the hybridization resulted in an increase in the FP values.	6-carboxyfluorescein	118-138	epidermal growth factor receptor	Homo sapiens	61-65
24672635-4	2014	The transport of carboxyfluorescein, a known MRP1 substrate, was measured by functional flow cytometry to evaluate MRP1 activity.	6-carboxyfluorescein	17-35	ATP binding cassette subfamily C member 1	Homo sapiens	45-49
24672635-4	2014	The transport of carboxyfluorescein, a known MRP1 substrate, was measured by functional flow cytometry to evaluate MRP1 activity.	6-carboxyfluorescein	17-35	ATP binding cassette subfamily C member 1	Homo sapiens	115-119
23869386-3	2013	The composite MB probe includes two loops and two stems, and two fluorophores of 6-carboxyfluorescein group (FAM) and tetramethyl-6-carboxyrhodamine (TAMRA) are connected to the two ends of molecular beacon.	6-carboxyfluorescein	81-101	ubiquitin like 5	Homo sapiens	200-206
23888876-4	2013	Hepcidin was selectively labeled with 6-carboxyfluorescein (CF) and 6-carboxytetramethylrhodamine (TMR) using Fmoc solid phase peptide chemistry.	6-carboxyfluorescein	38-58	hepcidin antimicrobial peptide	Homo sapiens	0-8
23888876-4	2013	Hepcidin was selectively labeled with 6-carboxyfluorescein (CF) and 6-carboxytetramethylrhodamine (TMR) using Fmoc solid phase peptide chemistry.	6-carboxyfluorescein	60-62	hepcidin antimicrobial peptide	Homo sapiens	0-8
23196129-4	2013	Tissue from either knockout mouse mediated the probenecid-inhibitable transport of the Oat substrate, 6-carboxyfluorescein (6CF), confirming the presence of Oat1 and Oat3 function.	6-carboxyfluorescein	102-122	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	166-170
23196129-4	2013	Tissue from either knockout mouse mediated the probenecid-inhibitable transport of the Oat substrate, 6-carboxyfluorescein (6CF), confirming the presence of Oat1 and Oat3 function.	6-carboxyfluorescein	124-127	solute carrier family 22 (organic anion transporter), member 8	Mus musculus	166-170
23548792-6	2013	NHE3 transcript levels and protein abundance in intestinal tissue were determined by confocal immunofluorescent microscopy, RT-PCR and western blotting, cytosolic pH (pHi) in intestinal cells from 2",7"-bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein (BCECF) fluorescence and Na(+)/H(+) exchanger activity from the Na(+) dependent realkalinization following an ammonium pulse.	6-carboxyfluorescein	234-252	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	0-4
22967603-1	2012	A hairpin molecular beacon tagged with carboxyfluorescein in combination with graphene oxide as a quencher reagent was used to detect the DNA damage by chemical reagents.	6-carboxyfluorescein	39-57	ubiquitin like 5	Homo sapiens	20-26
22219367-1	2012	A fluorescent molecular probe, 6-carboxy fluorescein, was used in conjunction with in situ fluorescence spectroscopy to facilitate real-time monitoring of degradation inducing reactive oxygen species within the polymer electrolyte membrane (PEM) of an operating PEM fuel cell.	6-carboxyfluorescein	31-52	mucin 1, cell surface associated	Homo sapiens	241-244
22219367-1	2012	A fluorescent molecular probe, 6-carboxy fluorescein, was used in conjunction with in situ fluorescence spectroscopy to facilitate real-time monitoring of degradation inducing reactive oxygen species within the polymer electrolyte membrane (PEM) of an operating PEM fuel cell.	6-carboxyfluorescein	31-52	mucin 1, cell surface associated	Homo sapiens	262-265
21205920-2	2011	We took advantage of this by generating two fluorescent bradykinin analogs containing 5(6)-carboxyfluorescein (CF) optionally used with the epsilon-aminocaproyl spacer condensed at the N terminus of the agonist.	6-carboxyfluorescein	86-109	kininogen 1	Homo sapiens	56-66
21440528-6	2011	In addition, substitutions in the BAX sequence modified the concentration dependency of carboxyfluorescein release in liposomes, although neither pore activity of the wild type or of any of the mutants significantly increased in cholesterol-enriched liposomes.	6-carboxyfluorescein	88-106	BCL2 associated X, apoptosis regulator	Homo sapiens	34-37
21514421-5	2011	In mice with a full deficiency of functional PLTP enhanced corneal epithelial damage, increased corneal permeability to carboxyfluorescein, and decreased corneal epithelial occludin expression were shown.	6-carboxyfluorescein	120-138	phospholipid transfer protein	Mus musculus	45-49
20237588-4	2010	Using 6-carboxyfluorescein (6-CF) as a substrate, the IC50 determinations for reduced DMPS (DMPSH) revealed a stronger interaction with OAT1 than with OAT3 (rbOAT1, 123.3 +/- 13.7; hOAT1, 85.1 +/- 8.8; rbOAT3, 171.7 +/- 22.3; and hOAT3, 172.2 +/- 36.4 micromol/L).	6-carboxyfluorescein	6-26	solute carrier family 22 member 6	Homo sapiens	136-140
20472914-3	2010	The proportion of both viable and dead spermatozoa expressing activated caspases was detected by flow cytometry through the use of different specific carboxyfluorescein-labeled caspase inhibitors.	6-carboxyfluorescein	150-168	caspase 8	Homo sapiens	72-80
20207772-4	2010	We assessed the relative number of EGFR gene copies by calculating the ratio of the number of EGFR molecules (measured with a 6-carboxyfluorescein-labeled Scorpion assay) to the number of molecules of the single-copy gene RPP30 (ribonuclease P/MRP 30kDa subunit) (measured with a 6-carboxy-X-rhodamine-labeled TaqMan assay) in each panel.	6-carboxyfluorescein	128-146	epidermal growth factor receptor	Homo sapiens	35-39
20721539-4	2010	The selected indicator 5(6)-carboxyfluorescein was conjugated with bovine serum albumin and its reaction was tested under different immobilization conditions.	6-carboxyfluorescein	24-46	albumin	Homo sapiens	80-87
20237588-4	2010	Using 6-carboxyfluorescein (6-CF) as a substrate, the IC50 determinations for reduced DMPS (DMPSH) revealed a stronger interaction with OAT1 than with OAT3 (rbOAT1, 123.3 +/- 13.7; hOAT1, 85.1 +/- 8.8; rbOAT3, 171.7 +/- 22.3; and hOAT3, 172.2 +/- 36.4 micromol/L).	6-carboxyfluorescein	6-26	solute carrier family 22 member 8	Homo sapiens	151-155
20237588-4	2010	Using 6-carboxyfluorescein (6-CF) as a substrate, the IC50 determinations for reduced DMPS (DMPSH) revealed a stronger interaction with OAT1 than with OAT3 (rbOAT1, 123.3 +/- 13.7; hOAT1, 85.1 +/- 8.8; rbOAT3, 171.7 +/- 22.3; and hOAT3, 172.2 +/- 36.4 micromol/L).	6-carboxyfluorescein	6-26	solute carrier family 22 member 6	Homo sapiens	181-186
20237588-4	2010	Using 6-carboxyfluorescein (6-CF) as a substrate, the IC50 determinations for reduced DMPS (DMPSH) revealed a stronger interaction with OAT1 than with OAT3 (rbOAT1, 123.3 +/- 13.7; hOAT1, 85.1 +/- 8.8; rbOAT3, 171.7 +/- 22.3; and hOAT3, 172.2 +/- 36.4 micromol/L).	6-carboxyfluorescein	6-26	solute carrier family 22 member 8	Homo sapiens	230-235
20237588-5	2010	However, inhibition of 6-CF uptake by the oxidized form of DMPS (DMPSS), the main form of DMPS in the blood, showed a greater affinity for OAT3 (rbOAT1, 237.4 +/- 23; hOAT1, 104.6 +/- 13.1; rbOAT3, 52.4 +/- 7.6; and hOAT3, 31.6 +/- 6.6 micromol/L).	6-carboxyfluorescein	23-27	solute carrier family 22 member 8	Homo sapiens	139-143
20237588-5	2010	However, inhibition of 6-CF uptake by the oxidized form of DMPS (DMPSS), the main form of DMPS in the blood, showed a greater affinity for OAT3 (rbOAT1, 237.4 +/- 23; hOAT1, 104.6 +/- 13.1; rbOAT3, 52.4 +/- 7.6; and hOAT3, 31.6 +/- 6.6 micromol/L).	6-carboxyfluorescein	23-27	solute carrier family 22 member 6	Homo sapiens	167-172
20237588-5	2010	However, inhibition of 6-CF uptake by the oxidized form of DMPS (DMPSS), the main form of DMPS in the blood, showed a greater affinity for OAT3 (rbOAT1, 237.4 +/- 23; hOAT1, 104.6 +/- 13.1; rbOAT3, 52.4 +/- 7.6; and hOAT3, 31.6 +/- 6.6 micromol/L).	6-carboxyfluorescein	23-27	solute carrier family 22 member 8	Homo sapiens	216-221
18296662-6	2008	Caspase-3 activation after glutamate treatment was determined with a carboxyfluorescein caspase-3 detection kit.	6-carboxyfluorescein	69-87	caspase 3	Mus musculus	0-9
18481835-3	2008	In this work, based on high affinity between antithrombin aptamer and thrombin (their dissociation constant is 0.5 nM), a carboxyfluorescein-labeled 29-nucleotide (nt) aptamer (F29-mer) was used and an aptamer-based affinity probe CE (aptamer-based APCE) method was successfully established for high-sensitive detection and quantitative analysis of thrombin.	6-carboxyfluorescein	122-140	coagulation factor II, thrombin	Homo sapiens	70-78
18481835-8	2008	Further binding experiments using one carboxyfluorescein-labeled aptamer and the other nonlabeled aptamer or vice versa were carried out to deduce the formation of ternary complex when these two aptamers coexisted in the free solution with thrombin.	6-carboxyfluorescein	38-56	coagulation factor II, thrombin	Homo sapiens	240-248
16569605-1	2006	The uptakes of endoglucanase and endoxylanase by soybean were studied by measuring the fluorescent intensity of a carboxyfluorescein.	6-carboxyfluorescein	114-132	endoglucanase	Glycine max	15-28
18092300-6	2008	Caspase-3 activation was detected by Western blotting, fluorometric assay of DEVD-AMC cleavage, and flow cytometry with carboxyfluorescein (FAM) labeled caspase inhibitor.	6-carboxyfluorescein	120-138	caspase 3	Homo sapiens	0-9
17940500-7	2007	Small interfering RNAs directed against MRP1 reduced MRP1 mRNA levels twofold and reduced efflux pump function of MRP1, which was reflected by a 1.8-fold higher accumulation of MRP1 substrate carboxyfluorescein, in si-MRP1 versus si-Luciferase-transfected GLC(4)-Adr cells.	6-carboxyfluorescein	192-210	ATP binding cassette subfamily B member 1	Homo sapiens	40-44
17940500-7	2007	Small interfering RNAs directed against MRP1 reduced MRP1 mRNA levels twofold and reduced efflux pump function of MRP1, which was reflected by a 1.8-fold higher accumulation of MRP1 substrate carboxyfluorescein, in si-MRP1 versus si-Luciferase-transfected GLC(4)-Adr cells.	6-carboxyfluorescein	192-210	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
17940500-7	2007	Small interfering RNAs directed against MRP1 reduced MRP1 mRNA levels twofold and reduced efflux pump function of MRP1, which was reflected by a 1.8-fold higher accumulation of MRP1 substrate carboxyfluorescein, in si-MRP1 versus si-Luciferase-transfected GLC(4)-Adr cells.	6-carboxyfluorescein	192-210	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
17940500-7	2007	Small interfering RNAs directed against MRP1 reduced MRP1 mRNA levels twofold and reduced efflux pump function of MRP1, which was reflected by a 1.8-fold higher accumulation of MRP1 substrate carboxyfluorescein, in si-MRP1 versus si-Luciferase-transfected GLC(4)-Adr cells.	6-carboxyfluorescein	192-210	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
17940500-7	2007	Small interfering RNAs directed against MRP1 reduced MRP1 mRNA levels twofold and reduced efflux pump function of MRP1, which was reflected by a 1.8-fold higher accumulation of MRP1 substrate carboxyfluorescein, in si-MRP1 versus si-Luciferase-transfected GLC(4)-Adr cells.	6-carboxyfluorescein	192-210	ATP binding cassette subfamily B member 1	Homo sapiens	53-57
18267146-2	2008	Modified thrombin binding aptamer (5"-NH-C3-GGTTGGTGTGGTTGG-C3-SH-3") carrying 6-carboxyfluorescein (FAM) and 7-amino-4-methyl-coumarin labels at 5" and 3", respectively, was used for the simultaneous combined measurement of Mg2+ and Ca2+ cations.	6-carboxyfluorescein	79-99	coagulation factor II, thrombin	Homo sapiens	9-17
17916326-7	2008	HbE and alpha-globin subunits were also found to induce greater leakage of membrane entrapped carboxyfluorescein (CF) using fluorescence measurements.	6-carboxyfluorescein	94-112	hemoglobin subunit epsilon 1	Homo sapiens	0-3
18990976-5	2008	Carboxyfluorescein (CF) was used as a model MRP1 substrate and was measured with functional flow cytometry.	6-carboxyfluorescein	0-18	ATP binding cassette subfamily C member 1	Homo sapiens	44-48
18990976-5	2008	Carboxyfluorescein (CF) was used as a model MRP1 substrate and was measured with functional flow cytometry.	6-carboxyfluorescein	20-22	ATP binding cassette subfamily C member 1	Homo sapiens	44-48
17614341-1	2007	The association behavior of the dyes 5(6)-carboxyfluorescein and nitrilotriacetic acid (NTA)-modified 5(6)-carboxyfluorescein (F-NTA) in a poly(vinyl alcohol) (PVA) film and in a PVA film containing metal nanoparticles is investigated.	6-carboxyfluorescein	102-125	farnesyltransferase, CAAX box, alpha	Homo sapiens	127-132
17912704-5	2007	In the human bronchial epithelial cell line 16HBE14o-, MRP1 function was studied flow cytometrically by cellular retention of carboxyfluorescein (CF) after CSE incubation and MRP1 downregulation by RNA interference (siRNA).	6-carboxyfluorescein	126-144	ATP binding cassette subfamily C member 1	Homo sapiens	55-59
15831282-6	2005	MAIN OUTCOME MEASURE(S): Active caspases-1, -3, -8, and -9 were examined in human spermatozoa by flow cytometry using carboxyfluorescein derivatives.	6-carboxyfluorescein	118-136	caspase 1	Homo sapiens	32-58
15970468-3	2005	An anisotropy binding assay was utilized to determine the K(d) of UNG and the R276 mutants for carboxyfluorescein-labeled uracil-containing single- and double-stranded oligonucleotides; the binding affinities varied 11-fold for single-stranded uracil-DNA, and 43-fold for double-stranded uracil-DNA.	6-carboxyfluorescein	95-113	uracil DNA glycosylase	Homo sapiens	66-69
16309213-10	2005	Carboxyfluorescein served as a substrate for MRP-mediated drug efflux, and indomethacine was the positive control used as an inhibitor of MRP in the flow cytometric experiments.	6-carboxyfluorescein	0-18	ATP binding cassette subfamily C member 3	Homo sapiens	45-48
15802127-5	2005	Using laser-induced fluorescence detection in the P/ACE MDQ instrument, primers 5" labeled with fluorescent probes such as 6-carboxyfluorescein can be rapidly separated and quantified.	6-carboxyfluorescein	123-143	angiotensin I converting enzyme	Homo sapiens	52-55
15571349-3	2004	A human alpha-thrombin binding aptamer was labeled with 6-carboxyfluorescein and exploited as a selective fluorescent probe for studying thrombin-protein interactions using capillary electrophoresis with laser-induced fluorescence.	6-carboxyfluorescein	56-76	coagulation factor II, thrombin	Homo sapiens	14-22
15571349-3	2004	A human alpha-thrombin binding aptamer was labeled with 6-carboxyfluorescein and exploited as a selective fluorescent probe for studying thrombin-protein interactions using capillary electrophoresis with laser-induced fluorescence.	6-carboxyfluorescein	56-76	coagulation factor II, thrombin	Homo sapiens	137-145
15553233-4	2004	Furthermore, cellular uptake of fluorescent P-gp substrate rhodamine-123 and MRP-substrate carboxyfluorescein has each been quantified in P-gp and MRP-expressing cells by flow cytometry under co-administration of PIs.	6-carboxyfluorescein	91-109	MARCKS like 1	Homo sapiens	77-80
15553233-4	2004	Furthermore, cellular uptake of fluorescent P-gp substrate rhodamine-123 and MRP-substrate carboxyfluorescein has each been quantified in P-gp and MRP-expressing cells by flow cytometry under co-administration of PIs.	6-carboxyfluorescein	91-109	ATP binding cassette subfamily B member 1	Homo sapiens	138-142
15553233-4	2004	Furthermore, cellular uptake of fluorescent P-gp substrate rhodamine-123 and MRP-substrate carboxyfluorescein has each been quantified in P-gp and MRP-expressing cells by flow cytometry under co-administration of PIs.	6-carboxyfluorescein	91-109	MARCKS like 1	Homo sapiens	147-150
15553233-8	2004	Additional MRP-inhibitory activities of H17 were proved by increasing cellular uptake rates of carboxyfluorescein in MRP-expressing cells.	6-carboxyfluorescein	95-113	MARCKS like 1	Homo sapiens	11-14
15553233-8	2004	Additional MRP-inhibitory activities of H17 were proved by increasing cellular uptake rates of carboxyfluorescein in MRP-expressing cells.	6-carboxyfluorescein	95-113	H1.7 linker histone	Homo sapiens	40-43
15553233-8	2004	Additional MRP-inhibitory activities of H17 were proved by increasing cellular uptake rates of carboxyfluorescein in MRP-expressing cells.	6-carboxyfluorescein	95-113	MARCKS like 1	Homo sapiens	117-120
14676187-6	2004	The carboxyfluorescein permeability of Cys-less hemichannels was increased by protein kinase C inhibition, like the wild-type Cx43 hemichannels.	6-carboxyfluorescein	4-22	gap junction protein alpha 1 S homeolog	Xenopus laevis	126-130
15161039-6	2004	The activity of MRP1 p-glycoprotein was studied in human breast cancer cell lines such as HTB-26/MRP1 and two MRP-negative breast cancer cell lines, T47D and MCF7, by carboxyfluorescein accumulation, and on a stomach cancer cell line.	6-carboxyfluorescein	167-185	ATP binding cassette subfamily C member 1	Homo sapiens	16-20
15161039-6	2004	The activity of MRP1 p-glycoprotein was studied in human breast cancer cell lines such as HTB-26/MRP1 and two MRP-negative breast cancer cell lines, T47D and MCF7, by carboxyfluorescein accumulation, and on a stomach cancer cell line.	6-carboxyfluorescein	167-185	ATP binding cassette subfamily B member 1	Homo sapiens	21-35
15161039-6	2004	The activity of MRP1 p-glycoprotein was studied in human breast cancer cell lines such as HTB-26/MRP1 and two MRP-negative breast cancer cell lines, T47D and MCF7, by carboxyfluorescein accumulation, and on a stomach cancer cell line.	6-carboxyfluorescein	167-185	ATP binding cassette subfamily C member 1	Homo sapiens	16-19
15161039-11	2004	The MRP-mediated carboxyfluorescein accumulation in HTB-26/MRP human breast cancer cells and daunorubicin accumulation in human stomach cancer cells 257P/MDR were not modified by these alis compounds.	6-carboxyfluorescein	17-35	ATP binding cassette subfamily C member 1	Homo sapiens	4-7
15076236-7	2004	P-gp and MRP1 functions were assayed using rhodamine 123 (Rh123) and carboxyfluorescein (CF) efflux assays, respectively.	6-carboxyfluorescein	69-87	ATP binding cassette subfamily C member 1	Homo sapiens	9-13
14719805-0	2003	Semisynthesis and application of carboxyfluorescein-labelled biologically active human interleukin-8.	6-carboxyfluorescein	33-51	C-X-C motif chemokine ligand 8	Homo sapiens	87-100
14719805-5	2003	Ligation with synthetic peptides that carry cysteine at their N-termini resulted in full-length hIL-8 and the specifically carboxyfluorescein-labelled analogue [K69(CF)]hIL-8(1-77).	6-carboxyfluorescein	123-141	C-X-C motif chemokine ligand 8	Homo sapiens	169-174
14624646-4	2003	Upon analyzing a collection of isomerically pure 5- and 6-carboxyfluorescein derivatives with different tether lengths, we found that conjugates based on 5-carboxyfluorescein gave significantly better results than the ones based on 6-carboxyfluorescein and that galectins-1 and -8 favored conjugates with different tether lengths than did galectin-3.	6-carboxyfluorescein	56-76	galectin 1	Homo sapiens	262-280
14624646-4	2003	Upon analyzing a collection of isomerically pure 5- and 6-carboxyfluorescein derivatives with different tether lengths, we found that conjugates based on 5-carboxyfluorescein gave significantly better results than the ones based on 6-carboxyfluorescein and that galectins-1 and -8 favored conjugates with different tether lengths than did galectin-3.	6-carboxyfluorescein	56-76	galectin 3	Homo sapiens	339-349
12879156-1	2003	We employed human red blood cells as a model system to check the affinity of MRP1 (Multidrug Resistance-associated Protein 1) towards fluorescein and a set of its carboxyl derivatives: 5/6-carboxyfluorescein (CF), 2",7"-bis-(2-carboxyethyl)-5/6-carboxyfluorescein (BCECF) and calcein (CAL).	6-carboxyfluorescein	187-207	ATP binding cassette subfamily C member 1	Homo sapiens	77-81
12801967-11	2003	Blocking Mrp activity by MK-571 resulted in accumulation of the Mrp specific substrate carboxyfluorescein in RLF phi 13 cells.	6-carboxyfluorescein	87-105	ATP binding cassette subfamily C member 2	Rattus norvegicus	9-12
12801967-11	2003	Blocking Mrp activity by MK-571 resulted in accumulation of the Mrp specific substrate carboxyfluorescein in RLF phi 13 cells.	6-carboxyfluorescein	87-105	ATP binding cassette subfamily C member 2	Rattus norvegicus	64-67
12801967-11	2003	Blocking Mrp activity by MK-571 resulted in accumulation of the Mrp specific substrate carboxyfluorescein in RLF phi 13 cells.	6-carboxyfluorescein	87-105	RLF zinc finger	Rattus norvegicus	109-112
12879156-1	2003	We employed human red blood cells as a model system to check the affinity of MRP1 (Multidrug Resistance-associated Protein 1) towards fluorescein and a set of its carboxyl derivatives: 5/6-carboxyfluorescein (CF), 2",7"-bis-(2-carboxyethyl)-5/6-carboxyfluorescein (BCECF) and calcein (CAL).	6-carboxyfluorescein	187-207	ATP binding cassette subfamily C member 1	Homo sapiens	83-124
14580229-10	2003	Using this novel two-color cross-correlation approach, the MTHFR genotypes, which were determined in 21 clinical samples, showed concordance with methods involving a PCR-based assay with hexachloro-6-carboxy-fluorescein (HEX)- and 6-carboxy-fluorescein (FAM)-tagged allele-specific primers and a subsequent separation step with capillary electrophoresis, yet are simpler to perform.	6-carboxyfluorescein	198-219	methylenetetrahydrofolate reductase	Homo sapiens	59-64
12458624-6	2002	Addition of either 5 or 50 mM FBP led to a significant increase (P < 0.05) in Egg PC carboxyfluorescein leakage.	6-carboxyfluorescein	88-106	fructose-bisphosphatase 1	Homo sapiens	30-33
12235484-9	2002	Finally, addition of syncollin to liposomes rendered them permeable to the water-soluble fluorescent probe 5(6)-carboxyfluorescein.	6-carboxyfluorescein	107-130	syncollin	Homo sapiens	21-30
12903137-1	2002	Potassium Sensing Oligonucleotide, PSO, showing a high selectivity for K+ was synthesized by connecting 6-FAM and 6-TAMRA at the 5"- and 3"-termini of d(GGG TTA GGG TTA GGG TTA GGG), respectively.	6-carboxyfluorescein	104-109	pipecolic acid and sarcosine oxidase	Homo sapiens	35-38
11986786-6	2002	Interaction of rhein with multidrug resistance-associated protein 1 was studied by carboxy fluorescein efflux and direct cytotoxicity by apoptosis induction.	6-carboxyfluorescein	83-102	ATP binding cassette subfamily C member 1	Homo sapiens	26-67
11477083-8	2001	Continuous measurement of probenecid-sensitive carboxyfluorescein efflux revealed that both mutations impaired the transport activity of MRP2.	6-carboxyfluorescein	47-65	ATP binding cassette subfamily C member 2	Homo sapiens	137-141
11587212-4	2001	P-gp and MRP activity varied strongly between the cases (rhodamine 123 efflux-blocking by PSC833: 5.4+/-7.7, and carboxyfluorescein efflux-blocking by MK-571: 4.3+/-6.7, n = 60).	6-carboxyfluorescein	113-131	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
11587212-4	2001	P-gp and MRP activity varied strongly between the cases (rhodamine 123 efflux-blocking by PSC833: 5.4+/-7.7, and carboxyfluorescein efflux-blocking by MK-571: 4.3+/-6.7, n = 60).	6-carboxyfluorescein	113-131	ATP binding cassette subfamily C member 1	Homo sapiens	9-12
11570504-5	2001	FAM-VAD-FMK is a carboxyfluorescein (FAM) derivative of benzyloxycarbonyl-valine-alanine-aspartic acid-fluoromethyl ketone (zVAD-FMK), which is a potent broad-spectrum inhibitor of caspases.	6-carboxyfluorescein	17-35	caspase 6	Homo sapiens	181-189
11087402-6	2000	T45G RNase A cleaves 6-FAM approximately dArAdAdA approximately 6-TAMRA 10(2)-fold faster than does the wild-type enzyme.	6-carboxyfluorescein	21-26	ribonuclease A family member 1, pancreatic	Homo sapiens	5-12
11305910-7	2001	Determination of the stability of the complex of wild-type RNase A and 6-carboxyfluorescein approximately d(AUAA) at varying pHs by fluorescence anisotropy shows that the stability increases by 2.4 kcal/mol as the pH decreases from 8.0 to 4.0.	6-carboxyfluorescein	71-91	ribonuclease A family member 1, pancreatic	Homo sapiens	59-66
11087402-11	2000	The affinity of wild-type RNase A for 6-FAM approximately d(AU(F)AA) is 50-fold lower than for 6-FAM approximately d(AUAA).	6-carboxyfluorescein	38-43	ribonuclease A family member 1, pancreatic	Homo sapiens	26-33
11087402-11	2000	The affinity of wild-type RNase A for 6-FAM approximately d(AU(F)AA) is 50-fold lower than for 6-FAM approximately d(AUAA).	6-carboxyfluorescein	95-100	ribonuclease A family member 1, pancreatic	Homo sapiens	26-33
10049676-8	1999	Full-length Bax was 25-fold more efficient, compared to C-terminal truncated Bax, in forming ion channels and trigger carboxyfluorescein release from liposomes.	6-carboxyfluorescein	118-136	BCL2 associated X, apoptosis regulator	Homo sapiens	12-15
10929807-5	2000	The assay is based on the inhibition of the transport of 6-carboxyfluorescein, a high-affinity hOAT1 substrate (Km = 3.9 microM), which was identified as one of several fluorescent organic anions.	6-carboxyfluorescein	57-77	solute carrier family 22 member 6	Homo sapiens	95-100
10929807-6	2000	The relative inhibition potency of various known hOAT1 substrates determined using the 6-carboxyfluorescein-based inhibition assay correlated well with their Km values, indicating that the fluorescent assay exhibits a proper specificity.	6-carboxyfluorescein	87-107	solute carrier family 22 member 6	Homo sapiens	49-54
10955805-3	2000	In the present study, the functional activity of P-gp and MRP was determined in 104 de novo AML patients with a flow cytometric assay using rhodamine 123 (Rh123) in combination with PSC833 and carboxyfluorescein (CF) in combination with MK-571.	6-carboxyfluorescein	193-211	ATP binding cassette subfamily B member 1	Homo sapiens	49-53
10955805-3	2000	In the present study, the functional activity of P-gp and MRP was determined in 104 de novo AML patients with a flow cytometric assay using rhodamine 123 (Rh123) in combination with PSC833 and carboxyfluorescein (CF) in combination with MK-571.	6-carboxyfluorescein	193-211	ATP binding cassette subfamily C member 1	Homo sapiens	58-61
10828037-4	2000	Functional activity of multidrug resistance protein (MRP) was studied in a flow cytometric assay with the use of the MRP substrate carboxyfluorescein (CF) and the inhibitor MK-571.	6-carboxyfluorescein	131-149	ATP binding cassette subfamily C member 1	Homo sapiens	23-51
10828037-4	2000	Functional activity of multidrug resistance protein (MRP) was studied in a flow cytometric assay with the use of the MRP substrate carboxyfluorescein (CF) and the inhibitor MK-571.	6-carboxyfluorescein	131-149	ATP binding cassette subfamily C member 1	Homo sapiens	53-56
10828037-4	2000	Functional activity of multidrug resistance protein (MRP) was studied in a flow cytometric assay with the use of the MRP substrate carboxyfluorescein (CF) and the inhibitor MK-571.	6-carboxyfluorescein	131-149	ATP binding cassette subfamily C member 1	Homo sapiens	117-120
10049676-8	1999	Full-length Bax was 25-fold more efficient, compared to C-terminal truncated Bax, in forming ion channels and trigger carboxyfluorescein release from liposomes.	6-carboxyfluorescein	118-136	BCL2 associated X, apoptosis regulator	Homo sapiens	77-80
9864036-5	1998	The probe used to detect the HLA-A specific amplicons was labeled at its 5" end with 6-carboxyfluorescein (FAM) as the reporter and at its 3" end with 6-carboxy-tetramethylrhodamine (TAMRA) as the quencher.	6-carboxyfluorescein	85-105	major histocompatibility complex, class I, A	Homo sapiens	29-34
9755890-5	1998	In addition, the permeation clearance (CLp) value of carboxyfluorescein (CF), a paracellular transport and undegradable marker, was increased in the presence of acyl-TGs.	6-carboxyfluorescein	53-71	calmodulin like 3	Homo sapiens	39-42
9676848-1	1998	To develop a functional assay for the activity of the multidrug resistance protein 1 (MRP1), we tested whether carboxyfluorescein (CF) was specifically transported by MRP and whether this transport pump could be specifically blocked by the leukotriene D4 receptor antagonist MK-571.	6-carboxyfluorescein	111-129	ATP binding cassette subfamily B member 1	Homo sapiens	54-84
9676848-1	1998	To develop a functional assay for the activity of the multidrug resistance protein 1 (MRP1), we tested whether carboxyfluorescein (CF) was specifically transported by MRP and whether this transport pump could be specifically blocked by the leukotriene D4 receptor antagonist MK-571.	6-carboxyfluorescein	111-129	ATP binding cassette subfamily B member 1	Homo sapiens	86-90
9676848-1	1998	To develop a functional assay for the activity of the multidrug resistance protein 1 (MRP1), we tested whether carboxyfluorescein (CF) was specifically transported by MRP and whether this transport pump could be specifically blocked by the leukotriene D4 receptor antagonist MK-571.	6-carboxyfluorescein	111-129	ATP binding cassette subfamily C member 1	Homo sapiens	86-89
9374773-3	1997	Leukocytes labeled with carboxyfluorescein were stimulated with cytokine-induced neutrophil chemoattractant (CINC/gro), which caused L-selectin shedding and inverse upregulation of CD18.	6-carboxyfluorescein	24-42	selectin L	Rattus norvegicus	133-143
9374773-3	1997	Leukocytes labeled with carboxyfluorescein were stimulated with cytokine-induced neutrophil chemoattractant (CINC/gro), which caused L-selectin shedding and inverse upregulation of CD18.	6-carboxyfluorescein	24-42	integrin subunit beta 2	Rattus norvegicus	181-185
9178074-6	1997	The fluorescent cell labelling dye carboxyfluorescein, diacetate, succinimidyl ester (CFSE) is used to show that many anti-Ig and CD40 stimulatory agents, used to assess the role of B cells and lymphokines, are partial agonists.	6-carboxyfluorescein	35-53	CD40 molecule	Homo sapiens	130-134
7554128-9	1995	Cx40 gap junctions were permeable to 2",7"-dichlorofluorescein (diCl-F) and also to the more polar 6-carboxyfluorescein dye; however, diCl-F dye transfer was not observed to increase with increasing junctional conductance.	6-carboxyfluorescein	99-119	gap junction protein, alpha 5	Rattus norvegicus	0-4
9219694-3	1997	Bax triggered the release of liposome-encapsulated carboxyfluorescein at both neutral and acidic pH.	6-carboxyfluorescein	51-69	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
9219694-5	1997	Bcl-2, in contrast, triggered carboxyfluorescein release at acidic pH only.	6-carboxyfluorescein	30-48	BCL2 apoptosis regulator	Homo sapiens	0-5