PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32771921-4	2020	METHODS: Docking studies were carried out in silico to evaluate the potential for interactions between three major phytosterol compounds (stigmasterol, beta-sitosterol, campesterol) and the DPP-4 enzyme, the enzyme that is inhibited by the anti-diabetic gliptins.	gamma-sitosterol	152-167	dipeptidyl peptidase 4	Homo sapiens	190-195
32771921-7	2020	RESULTS: In silico calculations predicted free binding energies for DPP-4 with the phytosterols to be: stigmasterol -8.78 kcal/mol; beta-sitosterol -8.70 kcal/mol; campesterol -8.40 kcal/mol.	gamma-sitosterol	132-147	dipeptidyl peptidase 4	Homo sapiens	68-73
31908573-0	2020	beta-Sitosterol treatment attenuates cognitive deficits and prevents amyloid plaque deposition in amyloid protein precursor/presenilin 1 mice.	gamma-sitosterol	0-15	presenilin 1	Mus musculus	124-136
31908573-5	2020	APP/PS1 mice were treated with beta-Sitosterol for four weeks, from the age of seven months.	gamma-sitosterol	31-46	amyloid beta (A4) precursor protein	Mus musculus	0-7
31908573-7	2020	We found that beta-Sitosterol treatment can improve spatial learning and recognition memory ability, and reduce plaque load in APP/PS1 mice.	gamma-sitosterol	14-29	amyloid beta (A4) precursor protein	Mus musculus	127-134
31908573-8	2020	beta-Sitosterol treatment helped reverse dendritic spine loss in APP/PS1 mice and reversed the decreased hippocampal neuron miniature excitatory postsynaptic current frequency.	gamma-sitosterol	0-15	amyloid beta (A4) precursor protein	Mus musculus	65-72
31908573-10	2020	Taken together, these findings suggest that beta-Sitosterol ameliorates memory and learning impairment in APP/PS1 mice and possibly decreases Abeta deposition.	gamma-sitosterol	44-59	amyloid beta (A4) precursor protein	Mus musculus	106-113
31653257-13	2019	Equally, 5alpha-cholestanol, campesterol, and beta-sitosterol to cholesterol ratios were higher in IUGR than in CTRL (17.2%, p < 0.004; 33.5%, p < 0.002; 29.3%, p < 0.021).	gamma-sitosterol	46-61	chymotrypsin like	Homo sapiens	112-116
31875004-0	2019	Assessment of the hepatoprotective effect of developed lipid-polymer hybrid nanoparticles (LPHNPs) encapsulating naturally extracted beta-Sitosterol against CCl4 induced hepatotoxicity in rats.	gamma-sitosterol	133-148	C-C motif chemokine ligand 4	Rattus norvegicus	157-161
31875004-4	2019	The results showed that the BSS-LPHNPs (400 mg/kg) have the ability to restore the liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), liver lipid peroxidation markers (malondialdehyde (MDA) and catalase (CAT)), total bilirubin and albumin to their normal levels without inhibitory effect on the CYP2E1 activity.	gamma-sitosterol	28-31	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	133-159
31875004-4	2019	The results showed that the BSS-LPHNPs (400 mg/kg) have the ability to restore the liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), liver lipid peroxidation markers (malondialdehyde (MDA) and catalase (CAT)), total bilirubin and albumin to their normal levels without inhibitory effect on the CYP2E1 activity.	gamma-sitosterol	28-31	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	161-164
31875004-4	2019	The results showed that the BSS-LPHNPs (400 mg/kg) have the ability to restore the liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)), liver lipid peroxidation markers (malondialdehyde (MDA) and catalase (CAT)), total bilirubin and albumin to their normal levels without inhibitory effect on the CYP2E1 activity.	gamma-sitosterol	28-31	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	329-335
30739226-5	2019	Although the diet contained nine times more sitosterol than campesterol, the concentration of sitosterol was lower than that of campesterol in plasma in LDLR-KO, and in the liver in controls and in LDLR-KO, but only in apoE-KO.	gamma-sitosterol	94-104	low density lipoprotein receptor	Mus musculus	153-157
31373816-0	2019	Effects of beta-Sitosterol from Corn Silk on TGF-beta1-Induced Epithelial-Mesenchymal Transition in Lung Alveolar Epithelial Cells.	gamma-sitosterol	11-26	transforming growth factor beta 1	Homo sapiens	45-54
31373816-5	2019	In this study, we elucidated that beta-sitosterol inhibited transforming growth factor-beta1 (TGF-beta1)-induced EMT and consequently had an antifibrotic effect.	gamma-sitosterol	34-49	transforming growth factor beta 1	Homo sapiens	94-103
31373816-6	2019	beta-Sitosterol (1-10 mug/mL) significantly downregulated the TGF-beta1-induced fibrotic proteins, such as collagen, fibronectin, and alpha-smooth muscle actin in human alveolar epithelial cells (p < 0.01).	gamma-sitosterol	0-15	transforming growth factor beta 1	Homo sapiens	62-71
31373816-6	2019	beta-Sitosterol (1-10 mug/mL) significantly downregulated the TGF-beta1-induced fibrotic proteins, such as collagen, fibronectin, and alpha-smooth muscle actin in human alveolar epithelial cells (p < 0.01).	gamma-sitosterol	0-15	fibronectin 1	Homo sapiens	117-128
31373816-8	2019	In addition, the changes of the TGF-beta1-induced morphological shape and protein expression of EMT markers, N-cadherin, vimentin, and E-cadherin, were significantly blocked by beta-sitosterol treatment (p < 0.01).	gamma-sitosterol	177-192	transforming growth factor beta 1	Homo sapiens	32-41
31373816-9	2019	The effects of beta-sitosterol on EMT were found to be associated with the TGF-beta1/Snail pathway, which is regulated by Smad and non-Smad signaling pathways.	gamma-sitosterol	15-30	transforming growth factor beta 1	Homo sapiens	75-84
31373816-10	2019	Taken together, these findings suggest that beta-sitosterol can be used to attenuate pulmonary fibrosis through suppression of EMT by inhibiting the TGF-beta1/Snail pathway.	gamma-sitosterol	44-59	transforming growth factor beta 1	Homo sapiens	149-158
31109298-6	2019	RESULTS: GhSMT2-1 overexpression led to changes of phytosterol content and the ratio of campesterol to sitosterol in fiber cell.	gamma-sitosterol	103-113	24-methylenesterol C-methyltransferase 2-like	Gossypium hirsutum	9-17
31109298-15	2019	There might be a specific ratio of campesterol to sitosterol in different developmental stage of cotton fibers, in which GhSMT2-1 play an important role.	gamma-sitosterol	50-60	24-methylenesterol C-methyltransferase 2-like	Gossypium hirsutum	121-129
30461321-9	2019	Results of the study showed that the treatment with beta-sitosterol to diabetes-induced rats normalized the altered levels of blood glucose, serum insulin and testosterone, lipid profile, oxidative stress markers, antioxidant enzymes, insulin receptor (IR), and glucose transporter 4 (GLUT4) proteins.	gamma-sitosterol	52-67	insulin receptor	Rattus norvegicus	235-251
30461321-9	2019	Results of the study showed that the treatment with beta-sitosterol to diabetes-induced rats normalized the altered levels of blood glucose, serum insulin and testosterone, lipid profile, oxidative stress markers, antioxidant enzymes, insulin receptor (IR), and glucose transporter 4 (GLUT4) proteins.	gamma-sitosterol	52-67	insulin receptor	Rattus norvegicus	253-255
30461321-9	2019	Results of the study showed that the treatment with beta-sitosterol to diabetes-induced rats normalized the altered levels of blood glucose, serum insulin and testosterone, lipid profile, oxidative stress markers, antioxidant enzymes, insulin receptor (IR), and glucose transporter 4 (GLUT4) proteins.	gamma-sitosterol	52-67	solute carrier family 2 member 4	Rattus norvegicus	262-283
30461321-9	2019	Results of the study showed that the treatment with beta-sitosterol to diabetes-induced rats normalized the altered levels of blood glucose, serum insulin and testosterone, lipid profile, oxidative stress markers, antioxidant enzymes, insulin receptor (IR), and glucose transporter 4 (GLUT4) proteins.	gamma-sitosterol	52-67	solute carrier family 2 member 4	Rattus norvegicus	285-290
30461321-10	2019	Our present findings indicate that beta-sitosterol improves glycemic control through activation of IR and GLUT4 in the adipose tissue of high fat and sucrose-induced type-2 diabetic rats.	gamma-sitosterol	35-50	insulin receptor	Rattus norvegicus	99-101
30461321-10	2019	Our present findings indicate that beta-sitosterol improves glycemic control through activation of IR and GLUT4 in the adipose tissue of high fat and sucrose-induced type-2 diabetic rats.	gamma-sitosterol	35-50	solute carrier family 2 member 4	Rattus norvegicus	106-111
30971321-12	2019	Finally, we observed completely abrogated BRAF inhibitor resistance when vemurafenib was combined with either beta-sitosterol or a functional knockdown of mitochondrial complex I.	gamma-sitosterol	110-125	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	42-46
30739226-9	2019	However, as compared to controls, in apoE-KO mice, but not in LDLR-KO mice, the increase in campesterol and sitosterol in plasma and in the whole body indicating that apoE-KO mice have a marked defect in the elimination of both phytosterols from the body.	gamma-sitosterol	108-118	apolipoprotein E	Mus musculus	167-171
30739226-5	2019	Although the diet contained nine times more sitosterol than campesterol, the concentration of sitosterol was lower than that of campesterol in plasma in LDLR-KO, and in the liver in controls and in LDLR-KO, but only in apoE-KO.	gamma-sitosterol	94-104	apolipoprotein E	Mus musculus	219-223
30739226-6	2019	On the other hand, in the intestine sitosterol was higher than campesterol in controls, and in LDLR-KO but with a tendency only in apoE-KO.	gamma-sitosterol	36-46	low density lipoprotein receptor	Mus musculus	95-99
30739226-6	2019	On the other hand, in the intestine sitosterol was higher than campesterol in controls, and in LDLR-KO but with a tendency only in apoE-KO.	gamma-sitosterol	36-46	apolipoprotein E	Mus musculus	131-135
30641046-9	2019	Therefore, isoleucine residues 351 and 461, and leucine residue 355 are important for the cytochrome P450scc functioning towards sterols both with unbranched (cholesterol) and branched (sitosterol) side chains.	gamma-sitosterol	186-196	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	90-108
30506375-8	2019	Mechanistic studies revealed that sitosterol-treatment reduced the expression of PI3K/Akt, promoted the activation of Bad, decreased Bcl-xl, and enhanced cyto-c release, leading to caspase-9 and caspase-3 activation, PARP cleavage, and apoptosis.	gamma-sitosterol	34-44	thymoma viral proto-oncogene 1	Mus musculus	86-89
30813582-5	2019	beta-sitosterol linearly decreased drip loss24h and malondialdehyde content, whereas linearly increased pH24h, superoxide dismutase activity, and mRNA abundances of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PCG-1alpha) and mitochondrial transcription factor A (TFAM) in breast muscle.	gamma-sitosterol	0-15	PPARG coactivator 1 alpha	Homo sapiens	165-232
30813582-5	2019	beta-sitosterol linearly decreased drip loss24h and malondialdehyde content, whereas linearly increased pH24h, superoxide dismutase activity, and mRNA abundances of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PCG-1alpha) and mitochondrial transcription factor A (TFAM) in breast muscle.	gamma-sitosterol	0-15	transcription factor A, mitochondrial	Homo sapiens	250-286
30813582-5	2019	beta-sitosterol linearly decreased drip loss24h and malondialdehyde content, whereas linearly increased pH24h, superoxide dismutase activity, and mRNA abundances of peroxisome proliferator-activated receptor gamma coactivator 1alpha (PCG-1alpha) and mitochondrial transcription factor A (TFAM) in breast muscle.	gamma-sitosterol	0-15	transcription factor A, mitochondrial	Homo sapiens	288-292
30813582-6	2019	Compared with control, levels of beta-sitosterol higher than 40 mg/kg reduced feed/gain ratio, muscular lightness24h, cooking loss24h, and malondialdehyde level, whereas increased muscular 2, 2-diphenyl-1-picrylhydrazyl scavenging activity, and mRNA abundances (except 60 mg/kg) of PCG-1alpha and TFAM.	gamma-sitosterol	33-48	transcription factor A, mitochondrial	Homo sapiens	297-301
30506375-8	2019	Mechanistic studies revealed that sitosterol-treatment reduced the expression of PI3K/Akt, promoted the activation of Bad, decreased Bcl-xl, and enhanced cyto-c release, leading to caspase-9 and caspase-3 activation, PARP cleavage, and apoptosis.	gamma-sitosterol	34-44	BCL2-like 1	Mus musculus	133-139
30506375-8	2019	Mechanistic studies revealed that sitosterol-treatment reduced the expression of PI3K/Akt, promoted the activation of Bad, decreased Bcl-xl, and enhanced cyto-c release, leading to caspase-9 and caspase-3 activation, PARP cleavage, and apoptosis.	gamma-sitosterol	34-44	caspase 3	Mus musculus	195-204
30506375-8	2019	Mechanistic studies revealed that sitosterol-treatment reduced the expression of PI3K/Akt, promoted the activation of Bad, decreased Bcl-xl, and enhanced cyto-c release, leading to caspase-9 and caspase-3 activation, PARP cleavage, and apoptosis.	gamma-sitosterol	34-44	poly (ADP-ribose) polymerase family, member 1	Mus musculus	217-221
30400936-11	2018	The molecular docking showed that licochalcone a and beta-sitosterol can closely bind two targets (BCL2 and PRKCA) that involved in EGFR-TKI resistance pathway.	gamma-sitosterol	53-68	BCL2 apoptosis regulator	Homo sapiens	99-103
30670971-0	2018	beta-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3beta Signaling.	gamma-sitosterol	0-15	AKT serine/threonine kinase 1	Homo sapiens	173-176
30670971-0	2018	beta-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3beta Signaling.	gamma-sitosterol	0-15	glycogen synthase kinase 3 beta	Homo sapiens	177-186
30323110-7	2019	Treatment with PCSK9-antibodies strongly decreased LDL-cholesterol, lathosterol, campesterol, and sitosterol (all P < 0.001) but hardly affected noncholesterol sterol to cholesterol ratios.	gamma-sitosterol	98-108	proprotein convertase subtilisin/kexin type 9	Homo sapiens	15-20
31473743-0	2019	beta-Sitosterol Attenuates the Intracranial Aneurysm Growth by Suppressing TNF-alpha-Mediated Mechanism.	gamma-sitosterol	0-15	tumor necrosis factor	Rattus norvegicus	75-84
31473743-9	2019	CONCLUSIONS: Treatment with beta-sitosterol suppresses the development of CA by inhibiting inflammatory reactions including TNF-alpha and thus beta-sitosterol can be a suggestive candidate for the prevention of CA treatment and progression.	gamma-sitosterol	28-43	tumor necrosis factor	Rattus norvegicus	124-133
30406661-2	2018	The natural soybean phytosterol, beta-sitosterol (BSS) demonstrated anticoagulant activity by dose-dependent inhibition of thrombin in an uncompetitive manner with a Ki value of 0.267 muM as well as by partial inhibition of thrombin-catalyzed platelet aggregation with a half-maximal inhibitory concentration (IC50) value of 10.45 +- 2.88 muM against platelet-rich plasma and 9.2 +- 1.2 muM against washed platelets.	gamma-sitosterol	33-48	coagulation factor II	Mus musculus	123-131
30400936-11	2018	The molecular docking showed that licochalcone a and beta-sitosterol can closely bind two targets (BCL2 and PRKCA) that involved in EGFR-TKI resistance pathway.	gamma-sitosterol	53-68	protein kinase C alpha	Homo sapiens	108-113
30400936-11	2018	The molecular docking showed that licochalcone a and beta-sitosterol can closely bind two targets (BCL2 and PRKCA) that involved in EGFR-TKI resistance pathway.	gamma-sitosterol	53-68	epidermal growth factor receptor	Homo sapiens	132-136
29675736-3	2018	Plasma cholesterol and phytosterols (campesterol and sitosterol) were higher in apoE-KO compared to control mice.	gamma-sitosterol	53-63	apolipoprotein E	Mus musculus	80-84
29221711-3	2018	We observed the existence of rather specific negative correlations between the serum sitosterol level and the serum IL-6 and the TNF-alpha levels in both diabetic subjects (n=46) and non-diabetic subjects (n=178).	gamma-sitosterol	85-95	interleukin 6	Mus musculus	116-120
29559312-0	2018	Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models.	gamma-sitosterol	23-38	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	55-59
29559312-0	2018	Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models.	gamma-sitosterol	23-38	phosphatase and tensin homolog	Homo sapiens	60-64
29559312-0	2018	Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models.	gamma-sitosterol	23-38	heat shock protein 90 alpha family class A member 1	Homo sapiens	65-70
29353227-12	2018	It is also well-known that LDL-receptor activity is increased, and this feasibly explains reduced LDL levels and consequent reduction of plasma cholesterol and sitosterol levels.	gamma-sitosterol	160-170	low density lipoprotein receptor	Homo sapiens	27-39
29221711-3	2018	We observed the existence of rather specific negative correlations between the serum sitosterol level and the serum IL-6 and the TNF-alpha levels in both diabetic subjects (n=46) and non-diabetic subjects (n=178).	gamma-sitosterol	85-95	tumor necrosis factor	Mus musculus	129-138
29221711-4	2018	Multiple regression analyses also revealed that the serum IL-6 and TNF-alpha levels exhibited strong negative correlations with the serum sitosterol levels.	gamma-sitosterol	138-148	interleukin 6	Mus musculus	58-62
29221711-4	2018	Multiple regression analyses also revealed that the serum IL-6 and TNF-alpha levels exhibited strong negative correlations with the serum sitosterol levels.	gamma-sitosterol	138-148	tumor necrosis factor	Mus musculus	67-76
29221711-5	2018	When ABCG5/8 KO mice with markedly elevated plasma sitosterol levels and ABCG5/8 hetero mice were fed a high-fat diet, we observed that the increase in body weight, the fatty liver changes, and the expansion of perigonadal adipose tissues were suppressed in ABCG5/8 KO mice without any modulation of food intake.	gamma-sitosterol	51-61	ATP binding cassette subfamily G member 5	Mus musculus	5-10
29391428-0	2018	beta-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.	gamma-sitosterol	0-15	thioredoxin	Homo sapiens	24-27
29391428-0	2018	beta-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.	gamma-sitosterol	0-15	tumor protein p53	Homo sapiens	126-129
29169939-12	2018	CONCLUSIONS: Our data indicate that about 4% of subjects with LDL-C concentrations >=190 mg/dL have plasma beta-sitosterol concentrations above the 99th percentile and about 0.3% have concentrations consistent with sitosterolemia.	gamma-sitosterol	110-125	component of oligomeric golgi complex 2	Homo sapiens	62-67
29542423-6	2018	These substances were tested against the tumor cell lines: beta-sitosterol and stigmasterol showed the most relevant activity to PC3 in CV assay and, oleanolic acid to B16F10 by the MTT assay.	gamma-sitosterol	59-74	chromobox 8	Homo sapiens	129-132
29379255-8	2017	Whereas, (3beta)-stigmast-5-en-3-ol isolated from Adathoda vasica and Aloe emodin isolated from Cassia fistula showed significant insulin mimetic effects favoring glucose uptake in L6 myotubes (an in vitro model mimicking skeletal muscle cells).	gamma-sitosterol	17-35	insulin	Homo sapiens	130-137
29056913-2	2017	The in vitro AChE, BChE inhibitory potentials of beta-sitosterol were investigated following Ellman"s assay.	gamma-sitosterol	49-64	butyrylcholinesterase	Mus musculus	19-23
29056913-6	2017	The molecular docking study was performed to predict the binding mode of beta-sitosterol in the active sites of AChE and BChE as inhibitor.	gamma-sitosterol	73-88	acetylcholinesterase	Mus musculus	112-116
29056913-6	2017	The molecular docking study was performed to predict the binding mode of beta-sitosterol in the active sites of AChE and BChE as inhibitor.	gamma-sitosterol	73-88	butyrylcholinesterase	Mus musculus	121-125
29056913-8	2017	beta-sitosterol exhibited an IC50 value of 55 and 50 mug/ml against AChE and BChE respectively.	gamma-sitosterol	0-15	acetylcholinesterase	Mus musculus	68-72
29056913-8	2017	beta-sitosterol exhibited an IC50 value of 55 and 50 mug/ml against AChE and BChE respectively.	gamma-sitosterol	0-15	butyrylcholinesterase	Mus musculus	77-81
28177669-1	2017	This study was designed to evaluate the effect of beta-sitosterol (BS) on the peroxisome proliferator-activated receptor gamma (PPAR-gamma) gene expression role in the activity of paraoxonase (PON-1) enzyme in oxidative stress status of irradiated rats.	gamma-sitosterol	50-65	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	78-126
28910707-5	2017	In this study, using a combination of di-4-ANEPPDHQ fluorescence and spectral phasor analysis, we report that the drought hypersensitive/squalene epoxidase (dry2/sqe1-5) mutant with reduced major sterols such as sitosterol and stigmasterol in roots presented higher membrane fluidity than the wild type.	gamma-sitosterol	212-222	FAD/NAD(P)-binding oxidoreductase family protein	Arabidopsis thaliana	162-168
28666833-8	2017	RESULTS: In differentiated C2C12 muscle cells and HepG2 hepatocellular cells, treatments with LOE and its active component (beta-sitosterol) induced significant AMPK phosphorylation.	gamma-sitosterol	124-139	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	161-165
28177669-1	2017	This study was designed to evaluate the effect of beta-sitosterol (BS) on the peroxisome proliferator-activated receptor gamma (PPAR-gamma) gene expression role in the activity of paraoxonase (PON-1) enzyme in oxidative stress status of irradiated rats.	gamma-sitosterol	50-65	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	128-138
28177669-1	2017	This study was designed to evaluate the effect of beta-sitosterol (BS) on the peroxisome proliferator-activated receptor gamma (PPAR-gamma) gene expression role in the activity of paraoxonase (PON-1) enzyme in oxidative stress status of irradiated rats.	gamma-sitosterol	50-65	paraoxonase 1	Rattus norvegicus	193-198
28216890-7	2017	To further confirm the inhibition of ERK-2 by beta-sitosterol, molecular docking study was performed.	gamma-sitosterol	46-61	mitogen activated protein kinase 1	Rattus norvegicus	37-42
27132025-0	2017	Oxidation of sitosterol and transport of its 7-oxygenated products from different tissues in humans and ApoE knockout mice.	gamma-sitosterol	13-23	apolipoprotein E	Homo sapiens	104-108
28440452-0	2017	BAMBI overexpression together with beta-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-beta/Smad2/3 pathway.	gamma-sitosterol	35-50	transforming growth factor beta 1	Homo sapiens	111-119
28440452-0	2017	BAMBI overexpression together with beta-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-beta/Smad2/3 pathway.	gamma-sitosterol	35-50	SMAD family member 2	Homo sapiens	120-127
28440452-2	2017	The BMP and activin receptor membrane bound inhibitor (BAMBI) has been identified as a hallmark of NSCLC and beta-sitosterol possesses antitumor potentiality.	gamma-sitosterol	109-124	bone morphogenetic protein 1	Homo sapiens	4-7
28440452-2	2017	The BMP and activin receptor membrane bound inhibitor (BAMBI) has been identified as a hallmark of NSCLC and beta-sitosterol possesses antitumor potentiality.	gamma-sitosterol	109-124	BMP and activin membrane bound inhibitor	Homo sapiens	55-60
28440452-4	2017	The results revealed that the transfection of pcDNA-BAMBI and beta-sitosterol treatment significantly reduced the levels of autophagy markers light chain 3 (LC3) II and Beclin 1, whereas the levels of LC3 I and p62 were promoted.	gamma-sitosterol	62-77	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	157-160
28440452-4	2017	The results revealed that the transfection of pcDNA-BAMBI and beta-sitosterol treatment significantly reduced the levels of autophagy markers light chain 3 (LC3) II and Beclin 1, whereas the levels of LC3 I and p62 were promoted.	gamma-sitosterol	62-77	beclin 1	Homo sapiens	169-177
28440452-4	2017	The results revealed that the transfection of pcDNA-BAMBI and beta-sitosterol treatment significantly reduced the levels of autophagy markers light chain 3 (LC3) II and Beclin 1, whereas the levels of LC3 I and p62 were promoted.	gamma-sitosterol	62-77	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	201-204
28440452-4	2017	The results revealed that the transfection of pcDNA-BAMBI and beta-sitosterol treatment significantly reduced the levels of autophagy markers light chain 3 (LC3) II and Beclin 1, whereas the levels of LC3 I and p62 were promoted.	gamma-sitosterol	62-77	nucleoporin 62	Homo sapiens	211-214
28440452-5	2017	The reduced punctate accumulations of GFP-LC3 were detected in pcDNA-BAMBI and beta-sitosterol groups, especially in pcDNA-BAMBI + beta-sitosterol group.	gamma-sitosterol	79-94	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	42-45
28440452-5	2017	The reduced punctate accumulations of GFP-LC3 were detected in pcDNA-BAMBI and beta-sitosterol groups, especially in pcDNA-BAMBI + beta-sitosterol group.	gamma-sitosterol	131-146	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	42-45
28440452-8	2017	The TGF-beta overexpression further confirmed that BAMBI overexpression and beta-sitosterol treatment suppre-ssed autohagy and viability of A549 cells was through TGF-beta/Smad2/3/c-Myc pathway.	gamma-sitosterol	76-91	transforming growth factor beta 1	Homo sapiens	4-12
28440452-8	2017	The TGF-beta overexpression further confirmed that BAMBI overexpression and beta-sitosterol treatment suppre-ssed autohagy and viability of A549 cells was through TGF-beta/Smad2/3/c-Myc pathway.	gamma-sitosterol	76-91	transforming growth factor beta 1	Homo sapiens	163-171
28440452-8	2017	The TGF-beta overexpression further confirmed that BAMBI overexpression and beta-sitosterol treatment suppre-ssed autohagy and viability of A549 cells was through TGF-beta/Smad2/3/c-Myc pathway.	gamma-sitosterol	76-91	SMAD family member 2	Homo sapiens	172-179
28440452-8	2017	The TGF-beta overexpression further confirmed that BAMBI overexpression and beta-sitosterol treatment suppre-ssed autohagy and viability of A549 cells was through TGF-beta/Smad2/3/c-Myc pathway.	gamma-sitosterol	76-91	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	180-185
28440452-9	2017	Finally, the tumor growth was suppressed in NSCLC xenografts, and the inhibitory effect was stronger under treatment of pcDNA-BAMBI toge-ther with beta-sitosterol.	gamma-sitosterol	147-162	BMP and activin membrane bound inhibitor	Homo sapiens	126-131
28216890-10	2017	The binding free energy obtained for beta-sitosterol for ERK-2 was found to be-5.578.	gamma-sitosterol	37-52	mitogen activated protein kinase 1	Rattus norvegicus	57-62
25614126-8	2015	Incubation of cultured myofibroblasts derived from stenotic valves with sitostanol or sitosterol decreased mRNA expression of the monocyte chemotactic protein-1 (p < 0.05) and interleukin-1 beta (p < 0.05).	gamma-sitosterol	86-96	C-C motif chemokine ligand 2	Homo sapiens	130-160
26891232-0	2016	Human CYP27A1 catalyzes hydroxylation of beta-sitosterol and ergosterol.	gamma-sitosterol	41-56	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	6-13
28216890-14	2017	The interaction of beta-sitosterol with the ATP binding site of ERK-2 by molecular docking studies also validates the inhibitory effect of beta-sitosterol on ERK-2.	gamma-sitosterol	19-34	mitogen activated protein kinase 1	Rattus norvegicus	64-69
28216890-14	2017	The interaction of beta-sitosterol with the ATP binding site of ERK-2 by molecular docking studies also validates the inhibitory effect of beta-sitosterol on ERK-2.	gamma-sitosterol	19-34	mitogen activated protein kinase 1	Rattus norvegicus	158-163
28216890-14	2017	The interaction of beta-sitosterol with the ATP binding site of ERK-2 by molecular docking studies also validates the inhibitory effect of beta-sitosterol on ERK-2.	gamma-sitosterol	139-154	mitogen activated protein kinase 1	Rattus norvegicus	64-69
28216890-14	2017	The interaction of beta-sitosterol with the ATP binding site of ERK-2 by molecular docking studies also validates the inhibitory effect of beta-sitosterol on ERK-2.	gamma-sitosterol	139-154	mitogen activated protein kinase 1	Rattus norvegicus	158-163
28216890-15	2017	The results of the present study reveal that beta-sitosterol inhibit oncogenic MAPK signaling, to abrogate hyper cell proliferation, angiogenesis, and to induce apoptosis thereby prevent DEN and Fe-NTA induced renal carcinogenesis.	gamma-sitosterol	45-60	mitogen activated protein kinase 1	Rattus norvegicus	79-83
27016394-4	2016	METHODS: We have studied the effects of beta-sitosterol, a phytosterol structurally related to cholesterol, on CCK receptor function.	gamma-sitosterol	40-55	cholecystokinin	Homo sapiens	111-114
27016394-6	2016	RESULTS: beta-sitosterol (100 muM and 10 muM) significantly improved the defective signaling of the CCK1R present in high cholesterol (p < 0.05), without affecting CCK binding affinity.	gamma-sitosterol	9-24	latexin	Homo sapiens	30-33
27016394-6	2016	RESULTS: beta-sitosterol (100 muM and 10 muM) significantly improved the defective signaling of the CCK1R present in high cholesterol (p < 0.05), without affecting CCK binding affinity.	gamma-sitosterol	9-24	latexin	Homo sapiens	41-44
27016394-6	2016	RESULTS: beta-sitosterol (100 muM and 10 muM) significantly improved the defective signaling of the CCK1R present in high cholesterol (p < 0.05), without affecting CCK binding affinity.	gamma-sitosterol	9-24	cholecystokinin A receptor	Homo sapiens	100-105
27016394-6	2016	RESULTS: beta-sitosterol (100 muM and 10 muM) significantly improved the defective signaling of the CCK1R present in high cholesterol (p < 0.05), without affecting CCK binding affinity.	gamma-sitosterol	9-24	cholecystokinin	Homo sapiens	100-103
27016394-8	2016	Furthermore, the cholesterol-insensitive Y140A mutant of CCK1R was resistant to the effects of beta-sitosterol.	gamma-sitosterol	95-110	cholecystokinin A receptor	Homo sapiens	57-62
27016394-9	2016	CONCLUSION: These data suggest that beta-sitosterol affects CCK1R function in high cholesterol by competing with cholesterol at a receptor cholesterol-binding site and may shift its conformation toward normal.	gamma-sitosterol	36-51	cholecystokinin A receptor	Homo sapiens	60-65
26982615-11	2016	CONCLUSIONS: Administration of beta-sitosterol to nephrotoxicity induced rats showed significant positive changes in biochemical parameters, histopathological and immunohistochemical observations, and up-regulation of Nrf2 gene expression.	gamma-sitosterol	31-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	218-222
27473871-10	2016	Pgp 9.5 expression was dose dependently upregulated by beta-sitosterol treatment in comparison to MNU treatment.	gamma-sitosterol	55-70	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	0-7
27473871-11	2016	On the contrary, downregulated NF-kB expression was perceived, when beta-sitosterol was concomitantly administered with MNU.	gamma-sitosterol	68-83	nuclear factor kappa B subunit 1	Rattus norvegicus	31-36
26620373-6	2016	The variations in lathosterol, sitosterol, and campesterol indicate that plasma PCSK9 levels are sensitive to changes in cholesterol synthesis and/or absorption.	gamma-sitosterol	31-41	proprotein convertase subtilisin/kexin type 9	Homo sapiens	80-85
25614126-8	2015	Incubation of cultured myofibroblasts derived from stenotic valves with sitostanol or sitosterol decreased mRNA expression of the monocyte chemotactic protein-1 (p < 0.05) and interleukin-1 beta (p < 0.05).	gamma-sitosterol	86-96	interleukin 1 beta	Homo sapiens	179-197
26314340-2	2015	We aimed to ascertain that beta-sitosterol (SI), which is one of the several phytosterols found mostly in foods, would regulate TSLP-induced mast cell proliferation.	gamma-sitosterol	27-42	thymic stromal lymphopoietin	Homo sapiens	128-132
26314340-2	2015	We aimed to ascertain that beta-sitosterol (SI), which is one of the several phytosterols found mostly in foods, would regulate TSLP-induced mast cell proliferation.	gamma-sitosterol	44-46	thymic stromal lymphopoietin	Homo sapiens	128-132
26314340-4	2015	SI significantly decreased the mRNA expression of Ki-67 in the TSLP-treated HMC-1 cells.	gamma-sitosterol	0-2	thymic stromal lymphopoietin	Homo sapiens	63-67
26139922-2	2015	The present study was aimed to compare the inhibitory potential of selected common dietary bioactive molecules (Gallic acid, Ellagic acid, beta-Sitosterol, Stigmasterol, Quercetin and Rutin) on CYP3A4 and CYP2D6 to assess safety through its inhibitory potency and to predict interaction potential with co-administered drugs.	gamma-sitosterol	139-154	cytochrome P450, family 2, subfamily d, polypeptide 4	Rattus norvegicus	205-211
26245821-8	2015	Sitosterol-rich fraction (SRF), obtained from HLP fractionation, reduced ear oedema on croton oil and phenol models at the same dose of dexamethasone (0.1 mg/ear).	gamma-sitosterol	0-10	cysteine rich protein 2	Mus musculus	46-49
26245821-10	2015	CONCLUSIONS: The mechanism of action of HLP was associated with the inhibition of several pro-inflammatory mediators, including cytokines, arachidonic acid metabolites and histamine, which suggested a glucocorticoid-like effect, reinforced by the presence of the steroid sitosterol.	gamma-sitosterol	271-281	cysteine rich protein 2	Mus musculus	40-43
25795151-0	2015	7beta-Hydroxysitosterol crosses the blood-brain barrier more favored than its substrate sitosterol in ApoE-/- mice.	gamma-sitosterol	13-23	apolipoprotein E	Mus musculus	102-106
26246145-9	2015	The beta-sitosterol content, as an indicator of phytosterols, was 0% in pure butter, and 1.81%, 1.67% and 2.16%, of the total sterols in the adulterated samples (B2, B3 and B4), respectively.	gamma-sitosterol	4-19	immunoglobulin kappa variable 5-2	Homo sapiens	162-175
25554578-0	2015	Incorporation of beta-sitosterol into the membrane prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB activation and gonadotropin-releasing hormone decline.	gamma-sitosterol	17-32	tumor necrosis factor	Mus musculus	60-87
25554578-0	2015	Incorporation of beta-sitosterol into the membrane prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB activation and gonadotropin-releasing hormone decline.	gamma-sitosterol	17-32	gonadotropin releasing hormone 1	Mus musculus	133-163
25554578-2	2015	beta-Sitosterol (BS), one of the most common phytosterols in the diet, is able to inhibit pro-inflammatory NF-kappaB signaling.	gamma-sitosterol	0-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
25554578-2	2015	beta-Sitosterol (BS), one of the most common phytosterols in the diet, is able to inhibit pro-inflammatory NF-kappaB signaling.	gamma-sitosterol	17-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
25554578-6	2015	It was found that incorporation of BS into the membrane could prevent tumor necrosis factor-alpha (TNF-alpha)-induced GnRH decline.	gamma-sitosterol	35-37	tumor necrosis factor	Mus musculus	70-97
25554578-6	2015	It was found that incorporation of BS into the membrane could prevent tumor necrosis factor-alpha (TNF-alpha)-induced GnRH decline.	gamma-sitosterol	35-37	tumor necrosis factor	Mus musculus	99-108
25554578-6	2015	It was found that incorporation of BS into the membrane could prevent tumor necrosis factor-alpha (TNF-alpha)-induced GnRH decline.	gamma-sitosterol	35-37	gonadotropin releasing hormone 1	Mus musculus	118-122
26199569-0	2015	Effect of beta-sitosterol on the expression of HPV E6 and p53 in cervical carcinoma cells.	gamma-sitosterol	10-25	tumor protein p53	Homo sapiens	58-61
26199569-6	2015	RESULTS: Treatment of Caski and HeLa cells with beta-sitosterol resulted in reduced expression of PCNA, indicative of an inhibitory effect on cell proliferation.	gamma-sitosterol	48-63	proliferating cell nuclear antigen	Homo sapiens	98-102
26382564-8	2015	Following CA condition, both beta-sitosterol and sitosterol glycoside quantity was more in Col-0 and p35S:TTG15/UGT80B1 restored lines, whereas it was significantly less in TTG15/UGT80B1 knockout mutants.	gamma-sitosterol	29-44	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	112-119
26078964-10	2015	Furthermore, other important genes-such as the chloride channel protein, cytochrome b, carboxypeptidase, peritrophic membrane chitin binding protein, and calphostin-may also play important roles in mites" response to beta-sitosterol.	gamma-sitosterol	217-232	CYTB	Tetranychus cinnabarinus	73-85
25257874-7	2014	Triterpene alcohols [cycloartenol (CA) and 24-methylene cycloartanol (24Me)], beta-sitosterol, and campesterol decreased the diet-induced secretion of GIP in C57BL/6J mice.	gamma-sitosterol	78-93	gastric inhibitory polypeptide	Mus musculus	151-154
24510054-0	2014	The beta-sitosterol attenuates atopic dermatitis-like skin lesions through down-regulation of TSLP.	gamma-sitosterol	4-19	thymic stromal lymphopoietin	Homo sapiens	94-98
25262005-6	2014	RESULTS: beta-sitosterol down regulated the mRNA and protein expression levels of collagen-1 and alpha-SMA in activated HSC.	gamma-sitosterol	9-24	actin alpha 2, smooth muscle, aorta	Mus musculus	97-106
25262005-8	2014	The mRNA and protein expression levels of collagen-1 and alpha-SMA were also down regulated in beta-sitosterol treated mouse group.	gamma-sitosterol	95-110	actin alpha 2, smooth muscle, aorta	Mus musculus	57-66
24905834-9	2014	Two SNPs (rs12247017 and rs12240292) in the sorbin and SH3 domain containing 1 (SORBS1) gene were associated with b-Sitosterol after correction for multiple testing (P<=4.5*10(-10)).	gamma-sitosterol	114-126	sorbin and SH3 domain containing 1	Homo sapiens	80-86
24402767-0	2014	beta-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-kappaB pathway.	gamma-sitosterol	0-15	toll-like receptor 4	Mus musculus	132-152
24402767-0	2014	beta-Sitosterol attenuates high-fat diet-induced intestinal inflammation in mice by inhibiting the binding of lipopolysaccharide to toll-like receptor 4 in the NF-kappaB pathway.	gamma-sitosterol	0-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	160-169
24402767-5	2014	The HFD-induced colonic inflammation evidenced by the increased expression of proinflammatory cytokines and the activation of nuclear factor kappa B (NF-kappaB) in the colon was also inhibited by beta-sitosterol.	gamma-sitosterol	196-211	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	126-148
24402767-5	2014	The HFD-induced colonic inflammation evidenced by the increased expression of proinflammatory cytokines and the activation of nuclear factor kappa B (NF-kappaB) in the colon was also inhibited by beta-sitosterol.	gamma-sitosterol	196-211	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
24402767-6	2014	In LPS-stimulated intestinal macrophages, beta-sitosterol inhibited the production of proinflammatory cytokines and inflammatory enzymes as well as NF-kappaB activation.	gamma-sitosterol	42-57	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	148-157
24402767-8	2014	Furthermore, beta-sitosterol potently inhibited the interaction between LPS and toll-like receptor 4 in intestinal macrophages transfected with control siRNA or MyD88 siRNA.	gamma-sitosterol	13-28	toll-like receptor 4	Mus musculus	72-100
24402767-8	2014	Furthermore, beta-sitosterol potently inhibited the interaction between LPS and toll-like receptor 4 in intestinal macrophages transfected with control siRNA or MyD88 siRNA.	gamma-sitosterol	13-28	myeloid differentiation primary response gene 88	Mus musculus	161-166
24402767-9	2014	CONCLUSION: These findings indicate that beta-sitosterol ameliorates HFD-induced colitis by inhibiting the binding of LPS to toll-like receptor 4 in the NF-kappaB pathway.	gamma-sitosterol	41-56	toll-like receptor 4	Mus musculus	125-145
24402767-9	2014	CONCLUSION: These findings indicate that beta-sitosterol ameliorates HFD-induced colitis by inhibiting the binding of LPS to toll-like receptor 4 in the NF-kappaB pathway.	gamma-sitosterol	41-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	153-162
24689699-0	2014	Chinese yam extracts containing beta-sitosterol and ethyl linoleate protect against atherosclerosis in apolipoprotein E-deficient mice and inhibit muscular expression of VCAM-1 in vitro.	gamma-sitosterol	32-47	vascular cell adhesion molecule 1	Mus musculus	170-176
24576758-4	2014	Using UDP-[U-(14)C]-glucose and beta-sitosterol or total crude membrane sterols as substrates, GhSGT1 and GhSGT2 recombinant proteins were detected with different enzymatic activities for SG production.	gamma-sitosterol	32-47	sterol 3-beta-glucosyltransferase UGT80A2-like	Gossypium hirsutum	95-101
24576758-4	2014	Using UDP-[U-(14)C]-glucose and beta-sitosterol or total crude membrane sterols as substrates, GhSGT1 and GhSGT2 recombinant proteins were detected with different enzymatic activities for SG production.	gamma-sitosterol	32-47	sterol 3-beta-glucosyltransferase UGT80B1	Gossypium hirsutum	106-112
23926302-6	2013	Plasma levels of soluble GPIbalpha were strongly correlated with plasma sitosterol levels in samples from human sitosterolemic patients, implicating a similar mechanism of sterol-induced platelet passivation in the human disease.	gamma-sitosterol	72-82	glycoprotein Ib platelet subunit alpha	Homo sapiens	25-34
23640957-7	2014	Furthermore, ROS scavenger N-acetyl L-cysteine attenuated beta-sitosterol-mediated sub-G1 accumulation, PARP cleavage, JNK and AMPK activation in U266 cells.	gamma-sitosterol	58-73	mitogen-activated protein kinase 8	Homo sapiens	119-122
23640957-7	2014	Furthermore, ROS scavenger N-acetyl L-cysteine attenuated beta-sitosterol-mediated sub-G1 accumulation, PARP cleavage, JNK and AMPK activation in U266 cells.	gamma-sitosterol	58-73	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	127-131
23640957-8	2014	Overall, these findings for the first time suggest that ROS-mediated activation of cancer metabolism-related genes such as AMPK and JNK plays an important role in beta-sitosterol-induced apoptosis in U266 multiple myeloma cells.	gamma-sitosterol	163-178	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	123-127
23640957-8	2014	Overall, these findings for the first time suggest that ROS-mediated activation of cancer metabolism-related genes such as AMPK and JNK plays an important role in beta-sitosterol-induced apoptosis in U266 multiple myeloma cells.	gamma-sitosterol	163-178	mitogen-activated protein kinase 8	Homo sapiens	132-135
23786821-8	2013	Buttermilk consumption increased plasma lathosterol concentrations (+12.1%, P = 0.001), but multiple regression analysis indicated that variations in beta-sitosterol concentrations (P = 0.002) were the only significant predictor of the LDL-C response to buttermilk consumption.	gamma-sitosterol	150-165	component of oligomeric golgi complex 2	Homo sapiens	236-241
23790892-4	2013	Eucalyptol, limonene, linalool, thymol, parthenolide, andrographolide, 18beta-glycyrrhetinic acid, lupeol, ursolic acid and beta-sitosterol showed a strong Th2-inclination and anti-inflammation potential in vitro.	gamma-sitosterol	124-139	heart and neural crest derivatives expressed 2	Mus musculus	156-159
23790892-5	2013	In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses.	gamma-sitosterol	98-113	interleukin 2	Mus musculus	154-158
23790892-5	2013	In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses.	gamma-sitosterol	98-113	negative elongation factor complex member C/D, Th1l	Mus musculus	160-163
23790892-5	2013	In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses.	gamma-sitosterol	98-113	interleukin 10	Mus musculus	169-174
23790892-5	2013	In addition, (-)-trans-caryophyllene, oridonin, triptolide, diosgenin, betulinic acid, escin, and beta-sitosterol treatments significantly inhibited both IL-2 (Th1) and IL-10 (Th2) cytokine production at the same time, suggesting that these terpenoid compounds have an anti-inflammation potential through the inhibition of T-cell immune responses.	gamma-sitosterol	98-113	heart and neural crest derivatives expressed 2	Mus musculus	176-179
24237052-2	2014	The aim of this study was to evaluate the contribution of impaired ATP-binding cassette transporter G5/8 (ABCG5/8) expression by diabetes to the increased beta-sitosterol (BS) exposure and impact of increased BS on integrity of blood-brain barrier (BBB).	gamma-sitosterol	155-170	ATP binding cassette subfamily G member 5	Rattus norvegicus	106-113
24237052-2	2014	The aim of this study was to evaluate the contribution of impaired ATP-binding cassette transporter G5/8 (ABCG5/8) expression by diabetes to the increased beta-sitosterol (BS) exposure and impact of increased BS on integrity of blood-brain barrier (BBB).	gamma-sitosterol	172-174	ATP binding cassette subfamily G member 5	Rattus norvegicus	106-113
23640957-0	2014	Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.	gamma-sitosterol	129-144	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	47-75
23640957-0	2014	Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.	gamma-sitosterol	129-144	mitogen-activated protein kinase 8	Homo sapiens	80-103
23640957-2	2014	Thus, in the present study, the role of reactive oxygen species (ROS) in association with AMP-activated protein kinase (AMPK) and c-Jun N-terminal kinase (JNK) pathways was demonstrated in beta-sitosterol-treated multiple myeloma U266 cells.	gamma-sitosterol	189-204	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	90-118
23640957-2	2014	Thus, in the present study, the role of reactive oxygen species (ROS) in association with AMP-activated protein kinase (AMPK) and c-Jun N-terminal kinase (JNK) pathways was demonstrated in beta-sitosterol-treated multiple myeloma U266 cells.	gamma-sitosterol	189-204	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	120-124
23640957-2	2014	Thus, in the present study, the role of reactive oxygen species (ROS) in association with AMP-activated protein kinase (AMPK) and c-Jun N-terminal kinase (JNK) pathways was demonstrated in beta-sitosterol-treated multiple myeloma U266 cells.	gamma-sitosterol	189-204	mitogen-activated protein kinase 8	Homo sapiens	130-153
23640957-2	2014	Thus, in the present study, the role of reactive oxygen species (ROS) in association with AMP-activated protein kinase (AMPK) and c-Jun N-terminal kinase (JNK) pathways was demonstrated in beta-sitosterol-treated multiple myeloma U266 cells.	gamma-sitosterol	189-204	mitogen-activated protein kinase 8	Homo sapiens	155-158
23640957-3	2014	Beta-sitosterol exerted cytotoxicity, increased sub-G1 apoptotic population and activated caspase-9 and -3, cleaved poly (ADP-ribose) polymerase (PARP) followed by decrease in mitochondrial potential in U266 cells.	gamma-sitosterol	0-15	caspase 9	Homo sapiens	90-106
23640957-3	2014	Beta-sitosterol exerted cytotoxicity, increased sub-G1 apoptotic population and activated caspase-9 and -3, cleaved poly (ADP-ribose) polymerase (PARP) followed by decrease in mitochondrial potential in U266 cells.	gamma-sitosterol	0-15	poly(ADP-ribose) polymerase 1	Homo sapiens	116-144
23640957-3	2014	Beta-sitosterol exerted cytotoxicity, increased sub-G1 apoptotic population and activated caspase-9 and -3, cleaved poly (ADP-ribose) polymerase (PARP) followed by decrease in mitochondrial potential in U266 cells.	gamma-sitosterol	0-15	poly(ADP-ribose) polymerase 1	Homo sapiens	146-150
23640957-4	2014	Beta-sitosterol promoted ROS production, activated AMPK, acetyl-CoA carboxylase (ACC) and JNK in U266 cells.	gamma-sitosterol	0-15	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	51-55
23640957-4	2014	Beta-sitosterol promoted ROS production, activated AMPK, acetyl-CoA carboxylase (ACC) and JNK in U266 cells.	gamma-sitosterol	0-15	mitogen-activated protein kinase 8	Homo sapiens	90-93
23640957-5	2014	Also, beta-sitosterol attenuated the phosphorylation of AKT, mammalian target of rapamycin and S6K, and the expression of cyclooxygenase-2 and VEGF in U266 cells.	gamma-sitosterol	6-21	mechanistic target of rapamycin kinase	Homo sapiens	61-90
23640957-5	2014	Also, beta-sitosterol attenuated the phosphorylation of AKT, mammalian target of rapamycin and S6K, and the expression of cyclooxygenase-2 and VEGF in U266 cells.	gamma-sitosterol	6-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	122-138
23640957-5	2014	Also, beta-sitosterol attenuated the phosphorylation of AKT, mammalian target of rapamycin and S6K, and the expression of cyclooxygenase-2 and VEGF in U266 cells.	gamma-sitosterol	6-21	vascular endothelial growth factor A	Homo sapiens	143-147
23640957-6	2014	Conversely, AMPK inhibitor compound C and JNK inhibitor SP600125 suppressed apoptosis induced by beta-sitosterol in U266 cells.	gamma-sitosterol	97-112	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	12-16
23640957-6	2014	Conversely, AMPK inhibitor compound C and JNK inhibitor SP600125 suppressed apoptosis induced by beta-sitosterol in U266 cells.	gamma-sitosterol	97-112	mitogen-activated protein kinase 8	Homo sapiens	42-45
23640957-7	2014	Furthermore, ROS scavenger N-acetyl L-cysteine attenuated beta-sitosterol-mediated sub-G1 accumulation, PARP cleavage, JNK and AMPK activation in U266 cells.	gamma-sitosterol	58-73	poly(ADP-ribose) polymerase 1	Homo sapiens	104-108
24074272-3	2014	MATERIALS AND METHODS: In silico studies were performed between human pancreatic alpha-amylase (HPA) and beta-sitosterol by using autodock 4.2 software.	gamma-sitosterol	105-120	amylase alpha 2A	Homo sapiens	70-94
23266618-0	2013	Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3beta signaling.	gamma-sitosterol	17-32	estrogen receptor 1 (alpha)	Mus musculus	119-136
23707801-0	2013	Substitution of membrane cholesterol with beta-sitosterol promotes nonamyloidogenic cleavage of endogenous amyloid precursor protein.	gamma-sitosterol	42-57	amyloid beta (A4) precursor protein	Mus musculus	107-132
24121260-0	2013	beta-Sitosterol modulates TLR4 receptor expression and intracellular MyD88-dependent pathway activation in J774A.1 murine macrophages.	gamma-sitosterol	0-15	toll-like receptor 4	Mus musculus	26-30
24121260-0	2013	beta-Sitosterol modulates TLR4 receptor expression and intracellular MyD88-dependent pathway activation in J774A.1 murine macrophages.	gamma-sitosterol	0-15	myeloid differentiation primary response gene 88	Mus musculus	69-74
24121260-2	2013	Our previous work shows that PS beta-Sitosterol (SIT), may function by down-regulating pro-inflammatory transcription factors NF-kB and STAT1 in response to LPS stimulation, possibly through modulation of the TLR4 pathway.	gamma-sitosterol	32-47	signal transducer and activator of transcription 1	Mus musculus	136-141
24121260-2	2013	Our previous work shows that PS beta-Sitosterol (SIT), may function by down-regulating pro-inflammatory transcription factors NF-kB and STAT1 in response to LPS stimulation, possibly through modulation of the TLR4 pathway.	gamma-sitosterol	32-47	toll-like receptor 4	Mus musculus	209-213
23266618-0	2013	Incorporation of beta-sitosterol into the membrane increases resistance to oxidative stress and lipid peroxidation via estrogen receptor-mediated PI3K/GSK3beta signaling.	gamma-sitosterol	17-32	glycogen synthase kinase 3 beta	Mus musculus	151-159
23250922-0	2013	beta-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2.	gamma-sitosterol	0-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	102-118
22669916-6	2012	[(3)H]sitosterol absorption was <2% in WT and ACAT2(-/-) mice, whereas it was up to 6.8% in G5G8(-/-) and DKO mice.	gamma-sitosterol	6-16	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	49-54
23415434-3	2013	RESULTS: Thirty-eight patients carrying the G allele of NPC1L1 showed significantly greater concentrations (log values) of campesterol (1.86 +- 0.3 vs 1.61 +- 0.3 10(2) mumol/mmol cholesterol, p < .001) and sitosterol (2.03 +- 0.2 vs 1.94 +- 0.2 10(2) mumol/mmol cholesterol, P = .05).	gamma-sitosterol	210-220	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	56-62
24088519-1	2013	The miscibility behavior of palmitoyl sphingomyelin (PSM) with phytosterol derivatives of beta-sitosterol (SITO), beta-sitosteryl glucoside (SG), and beta-sitosteryl glucoside palmitate (SGP) was systematically investigated using Langmuir monolayers.	gamma-sitosterol	90-105	folate hydrolase 1B (pseudogene)	Homo sapiens	53-56
24088519-1	2013	The miscibility behavior of palmitoyl sphingomyelin (PSM) with phytosterol derivatives of beta-sitosterol (SITO), beta-sitosteryl glucoside (SG), and beta-sitosteryl glucoside palmitate (SGP) was systematically investigated using Langmuir monolayers.	gamma-sitosterol	107-111	folate hydrolase 1B (pseudogene)	Homo sapiens	53-56
23215694-7	2013	beta-Sitosterol inhibited myeloperoxidase and adenosine deaminase activity, and IL-1beta and TNF-alpha levels.	gamma-sitosterol	0-15	myeloperoxidase	Mus musculus	26-41
23215694-7	2013	beta-Sitosterol inhibited myeloperoxidase and adenosine deaminase activity, and IL-1beta and TNF-alpha levels.	gamma-sitosterol	0-15	adenosine deaminase	Mus musculus	46-65
23215694-8	2013	CONCLUSIONS: beta-Sitosterol inhibited either myeloperoxidase and adenosine deaminase activity or IL-1beta and TNF-alpha levels.	gamma-sitosterol	13-28	myeloperoxidase	Mus musculus	46-61
23215694-8	2013	CONCLUSIONS: beta-Sitosterol inhibited either myeloperoxidase and adenosine deaminase activity or IL-1beta and TNF-alpha levels.	gamma-sitosterol	13-28	adenosine deaminase	Mus musculus	66-85
23215694-8	2013	CONCLUSIONS: beta-Sitosterol inhibited either myeloperoxidase and adenosine deaminase activity or IL-1beta and TNF-alpha levels.	gamma-sitosterol	13-28	interleukin 1 beta	Mus musculus	98-106
23215694-8	2013	CONCLUSIONS: beta-Sitosterol inhibited either myeloperoxidase and adenosine deaminase activity or IL-1beta and TNF-alpha levels.	gamma-sitosterol	13-28	tumor necrosis factor	Mus musculus	111-120
23627133-4	2012	RESULTS: Among the sixteen orthogonal design groups, the ulcer area of these groups using both beta-sitosterol and berberine was the smallest (P < 0.05), the content of Leptin of these groups using both glycyrrhetic acid and ginsenoside was the highest in blood serum (P < 0.05), the group using glycyrrhetic acid had the minimum concentration of ET-1 in blood plasma.	gamma-sitosterol	95-110	leptin	Rattus norvegicus	172-178
23627133-5	2012	Compared with model group, berberine could raise the mRNA expression level of Leptin (P < 0.01), and beta-sitosterol could lower the mRNA expression level of ET-1 (P < 0.01).	gamma-sitosterol	104-119	endothelin 1	Rattus norvegicus	161-165
22160579-9	2012	The complex of beta-sitosterol was prepared with phosphatidyl choline and characterized on the basis of solubility, melting point, TLC, UV, IR and NMR spectroscopy.	gamma-sitosterol	15-30	lipocalin 1	Homo sapiens	131-134
23299431-2	2013	We had previously demonstrated that the Arabidopsis Atcyp710A1 gene, which catalyzes conversion of sitosterol into stigmasterol, plays a role in plasma membrane permeability, thus influencing leakage of cellular nutrients and ions into apoplast.	gamma-sitosterol	99-109	cytochrome P450, family 710, subfamily A, polypeptide 1	Arabidopsis thaliana	52-62
23205552-5	2012	The contents of bioactive compounds (diosgenin, stigmasterol, and beta-sitosterol) were significantly increased by media-milling, which enhanced the secretion of hTGF-beta and inhibited the formation of MMP-1.	gamma-sitosterol	66-81	transforming growth factor beta 1	Homo sapiens	162-171
23205552-5	2012	The contents of bioactive compounds (diosgenin, stigmasterol, and beta-sitosterol) were significantly increased by media-milling, which enhanced the secretion of hTGF-beta and inhibited the formation of MMP-1.	gamma-sitosterol	66-81	matrix metallopeptidase 1	Homo sapiens	203-208
22018049-9	2012	Adjusted LDL-C reductions were variably enhanced in participants with basal low serum lathosterol/C or conversely high sitosterol/C and campesterol/C.	gamma-sitosterol	119-129	component of oligomeric golgi complex 2	Homo sapiens	9-14
21814861-5	2011	SANS data on suspensions of unilamellar vesicles showed that both cholesterol and beta-sitosterol similarly increase the EYPC bilayer thickness.	gamma-sitosterol	82-97	USH1 protein network component sans	Homo sapiens	0-4
22353013-8	2012	beta-Sitosterol also exhibited a protective action against DMH-induced depletion of antioxidants such as catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and reduced glutathione in colonic and hepatic tissues of experimental animals.	gamma-sitosterol	0-15	catalase	Rattus norvegicus	105-113
22353013-8	2012	beta-Sitosterol also exhibited a protective action against DMH-induced depletion of antioxidants such as catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and reduced glutathione in colonic and hepatic tissues of experimental animals.	gamma-sitosterol	0-15	glutathione-disulfide reductase	Rattus norvegicus	161-182
22353013-8	2012	beta-Sitosterol also exhibited a protective action against DMH-induced depletion of antioxidants such as catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione S-transferase, and reduced glutathione in colonic and hepatic tissues of experimental animals.	gamma-sitosterol	0-15	hematopoietic prostaglandin D synthase	Rattus norvegicus	184-209
22298683-6	2012	The Arabidopsis cytochrome P450 CYP710A1, which encodes C22-sterol desaturase that converts beta-sitosterol to stigmasterol, was dramatically induced upon inoculation with nonhost pathogens.	gamma-sitosterol	92-107	cytochrome P450, family 710, subfamily A, polypeptide 1	Arabidopsis thaliana	32-40
23061909-6	2012	When examined separately, walnut components ALA and beta-sitosterol were the most efficacious activators of FXR.	gamma-sitosterol	52-67	nuclear receptor subfamily 1 group H member 4	Homo sapiens	108-111
22538477-3	2012	beta-Sitosterol inhibited colon shortening and led to lowered macroscopic scores and myeloperoxidase activity in TNBS-treated colitic mice.	gamma-sitosterol	0-15	myeloperoxidase	Mus musculus	85-100
22538477-4	2012	beta-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-kappaB.	gamma-sitosterol	0-15	tumor necrosis factor	Mus musculus	75-84
22538477-4	2012	beta-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-kappaB.	gamma-sitosterol	0-15	interleukin 1 beta	Mus musculus	86-94
22538477-4	2012	beta-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-kappaB.	gamma-sitosterol	0-15	interleukin 6	Mus musculus	100-104
22538477-4	2012	beta-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-kappaB.	gamma-sitosterol	0-15	cytochrome c oxidase II, mitochondrial	Mus musculus	134-156
22538477-4	2012	beta-Sitosterol also inhibited the expression of proinflammatory cytokines TNF-alpha, IL-1beta, and IL-6, and an inflammatory enzyme, cyclooxygenase (COX)-2, in the colons of TNBS-induced colitic mice, as well as the activation of NF-kappaB.	gamma-sitosterol	0-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	231-240
22538477-5	2012	Based on these findings, beta-sitosterol may ameliorate colitis by inhibiting the NF-kappaB pathway.	gamma-sitosterol	25-40	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
22490085-7	2012	With sitosterol, campesterol, and 7-ketositosterol, IL-8 secretion was decreased, and with campesterol the intracellular polar lipid level was reduced.	gamma-sitosterol	5-15	C-X-C motif chemokine ligand 8	Homo sapiens	52-56
21969169-4	2011	Using human platelets, a type of peripheral blood cells containing the most circulating amyloid precursor protein (APP), this study investigated the effect of beta-sitosterol on high cholesterol-induced secretion of beta amyloid protein (Abeta).	gamma-sitosterol	159-174	amyloid beta precursor protein	Homo sapiens	238-243
21969169-5	2011	It was found that beta-sitosterol effectively inhibited high cholesterol-driven platelet Abeta release.	gamma-sitosterol	18-33	amyloid beta precursor protein	Homo sapiens	89-94
21969169-6	2011	In addition, beta-sitosterol prevented high cholesterol-induced increase of activities of beta- and gamma-secretase, two APP cleaving enzymes to generate Abeta.	gamma-sitosterol	13-28	amyloid beta precursor protein	Homo sapiens	154-159
21969169-9	2011	These findings suggest that beta-sitosterol is able to inhibit high cholesterol-induced Abeta release probably through maintenance of membrane cholesterol homeostasis.	gamma-sitosterol	28-43	amyloid beta precursor protein	Homo sapiens	88-93
21356343-0	2011	beta-Sitosterol down-regulates some pro-inflammatory signal transduction pathways by increasing the activity of tyrosine phosphatase SHP-1 in J774A.1 murine macrophages.	gamma-sitosterol	0-15	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	133-138
20731356-5	2010	Flow cytometric analysis revealed that beta-sitosterol arrested cell cycle progression through down-regulation of cyclin E and cyclin-dependent kinase (CDK)2 and up-regulation of p21cip1.	gamma-sitosterol	39-54	cyclin E1	Rattus norvegicus	114-122
20946894-9	2011	Furthermore, beta-sitosterol treatment suppressed the increase in cytokine levels (TNFalpha, IL-4 and IL-5), with the exception of IL-6, in serum and in bronchoalveolar lavaged fluid detected in model control animals.	gamma-sitosterol	13-28	tumor necrosis factor	Cavia porcellus	83-91
20946894-9	2011	Furthermore, beta-sitosterol treatment suppressed the increase in cytokine levels (TNFalpha, IL-4 and IL-5), with the exception of IL-6, in serum and in bronchoalveolar lavaged fluid detected in model control animals.	gamma-sitosterol	13-28	interleukin-4	Cavia porcellus	93-97
20946894-9	2011	Furthermore, beta-sitosterol treatment suppressed the increase in cytokine levels (TNFalpha, IL-4 and IL-5), with the exception of IL-6, in serum and in bronchoalveolar lavaged fluid detected in model control animals.	gamma-sitosterol	13-28	interleukin-5	Cavia porcellus	102-106
21266789-7	2011	At high concentrations, Chol induced a significant increase in TNF-alpha secretions from both cells; however, Sito resulted in a non-significant increase in TNF-alpha secretion.	gamma-sitosterol	110-114	tumor necrosis factor	Mus musculus	157-166
21266789-8	2011	The effects on IL-6 secretions of Sito were also significantly less than those of Chol.	gamma-sitosterol	34-38	interleukin 6	Mus musculus	15-19
20865301-5	2010	Sterol analyses of transgenic Arabidopsis seeds originating in variant constructs of AtHMGR1, GmSMT1, and GmSMT2 engineered in seeds showed relevant modifications in the ratio of 24-methyl to 24-ethyl sterol in the direction of sitosterol formation.	gamma-sitosterol	228-238	hydroxy methylglutaryl CoA reductase 1	Arabidopsis thaliana	85-92
20731356-5	2010	Flow cytometric analysis revealed that beta-sitosterol arrested cell cycle progression through down-regulation of cyclin E and cyclin-dependent kinase (CDK)2 and up-regulation of p21cip1.	gamma-sitosterol	39-54	cyclin dependent kinase 2	Rattus norvegicus	152-157
20731356-6	2010	In the beta-sitosterol-treated RASMCs, the formation of the CDK2-p21cip1 complex was increased and the assayable CDK2 activity was decreased.	gamma-sitosterol	7-22	cyclin dependent kinase 2	Rattus norvegicus	60-64
20731356-6	2010	In the beta-sitosterol-treated RASMCs, the formation of the CDK2-p21cip1 complex was increased and the assayable CDK2 activity was decreased.	gamma-sitosterol	7-22	cyclin dependent kinase 2	Rattus norvegicus	113-117
20731356-8	2010	In conclusion, beta-sitosterol inhibited VSMC proliferation by increasing the levels of p21cip1 protein, which in turn inhibited the CDK2 activity, and finally interrupted the progress of the cell cycle.	gamma-sitosterol	15-30	cyclin dependent kinase 2	Rattus norvegicus	133-137
20558233-0	2010	beta-sitosterol among other secondary metabolites of Piper galeatum shows inhibition of TNFalpha-induced cell adhesion molecule expression on human endothelial cells.	gamma-sitosterol	0-15	tumor necrosis factor	Homo sapiens	88-96
20558233-6	2010	beta-sitosterol also significantly inhibited the TNFalpha-induced expression of VCAM-1 and E-selectin, which also play key role in various inflammatory diseases.	gamma-sitosterol	0-15	tumor necrosis factor	Homo sapiens	49-57
20558233-6	2010	beta-sitosterol also significantly inhibited the TNFalpha-induced expression of VCAM-1 and E-selectin, which also play key role in various inflammatory diseases.	gamma-sitosterol	0-15	vascular cell adhesion molecule 1	Homo sapiens	80-86
20558233-6	2010	beta-sitosterol also significantly inhibited the TNFalpha-induced expression of VCAM-1 and E-selectin, which also play key role in various inflammatory diseases.	gamma-sitosterol	0-15	selectin E	Homo sapiens	91-101
20558233-9	2010	To elucidate the molecular mechanism of inhibition of cell adhesion molecules, we investigated the status of nuclear transcription factor-kappaB (NF-kappaB) and were able to establish that beta-sitosterol significantly blocked the TNFalpha-induced activation of NF-kappaB.	gamma-sitosterol	189-204	nuclear factor kappa B subunit 1	Homo sapiens	109-144
20558233-9	2010	To elucidate the molecular mechanism of inhibition of cell adhesion molecules, we investigated the status of nuclear transcription factor-kappaB (NF-kappaB) and were able to establish that beta-sitosterol significantly blocked the TNFalpha-induced activation of NF-kappaB.	gamma-sitosterol	189-204	nuclear factor kappa B subunit 1	Homo sapiens	146-155
20558233-9	2010	To elucidate the molecular mechanism of inhibition of cell adhesion molecules, we investigated the status of nuclear transcription factor-kappaB (NF-kappaB) and were able to establish that beta-sitosterol significantly blocked the TNFalpha-induced activation of NF-kappaB.	gamma-sitosterol	189-204	tumor necrosis factor	Homo sapiens	231-239
20558233-9	2010	To elucidate the molecular mechanism of inhibition of cell adhesion molecules, we investigated the status of nuclear transcription factor-kappaB (NF-kappaB) and were able to establish that beta-sitosterol significantly blocked the TNFalpha-induced activation of NF-kappaB.	gamma-sitosterol	189-204	nuclear factor kappa B subunit 1	Homo sapiens	262-271
20843282-6	2010	It was also shown that the beta-sitosterol was significantly more cytotoxic in cells with basal ABCB1 expression (MCF7) than in multidrug resistant NCI/ADR-RES.	gamma-sitosterol	27-42	ATP binding cassette subfamily B member 1	Homo sapiens	96-101
19615880-4	2010	We found that PCE hydrolyzes palmitate, oleate and stearate esters of cholesterol, stigmasterol, stigmastanol and sitosterol.	gamma-sitosterol	114-124	carboxyl ester lipase	Homo sapiens	14-17
20138281-8	2010	Here mutations in either the ABCG5 or G8 loci, prevents hepatocytes and enterocytes from excreting cholesterol and plant sterols, including sitosterol, into the bile and intestinal lumen.	gamma-sitosterol	140-150	ATP binding cassette subfamily G member 5	Homo sapiens	29-34
20436182-9	2010	Peripheral insulin sensitivity evaluated by the Matsuda index was associated with the lathosterol/sitosterol ratio in the entire population (r = -0.457, P < 0.001) and with that of lathosterol/cholestanol independently of obesity.	gamma-sitosterol	98-108	insulin	Homo sapiens	11-18
20497375-9	2010	Lack of FPS2 activity in seeds, but not of FPS1 activity, is associated with a marked reduction in sitosterol content and positive feedback regulation of 3-hydroxy-3-methylglutaryl CoA reductase activity that renders seeds hypersensitive to the 3-hydroxy-3-methylglutaryl CoA reductase inhibitor mevastatin.	gamma-sitosterol	99-109	farnesyl diphosphate synthase 2	Arabidopsis thaliana	8-12
20356594-11	2010	Insulin-resistant patients had higher levels of cholesterol synthesis markers (desmosterol, lathosterol) and lower levels of absorption markers (cholestanol, sitosterol) and the correlation between QUICKI and percent LDL-C response ceased to be significant when these factors were controlled for.	gamma-sitosterol	158-168	insulin	Homo sapiens	0-7
20843282-9	2010	We also show that PgP activity (responsible for Multidrug Resistance phenomena) is inhibited by beta-sitosterol.	gamma-sitosterol	96-111	phosphoglycolate phosphatase	Homo sapiens	18-21
20491082-2	2010	CT1 consists of stigmasterol (32%), beta-sitosterol (40.3%), and campesterol (27.7%) as determined by capillary gas chromatography.	gamma-sitosterol	36-51	cardiotrophin 1	Homo sapiens	0-3
20444228-3	2010	Stigmasterol is synthesized from beta-sitosterol by the cytochrome P450 CYP710A1 via C22 desaturation.	gamma-sitosterol	33-48	cytochrome P450, family 710, subfamily A, polypeptide 1	Arabidopsis thaliana	72-80
20525330-8	2010	RESULTS: beta-sitosterol induced significant dose-dependent growth inhibition of COLO 320 DM cells (IC50 266.2 microM), induced apoptosis by scavenging reactive oxygen species, and suppressed the expression of beta-catenin and PCNA antigens in human colon cancer cells.	gamma-sitosterol	9-24	catenin beta 1	Homo sapiens	210-222
20525330-8	2010	RESULTS: beta-sitosterol induced significant dose-dependent growth inhibition of COLO 320 DM cells (IC50 266.2 microM), induced apoptosis by scavenging reactive oxygen species, and suppressed the expression of beta-catenin and PCNA antigens in human colon cancer cells.	gamma-sitosterol	9-24	proliferating cell nuclear antigen	Homo sapiens	227-231
20015521-7	2010	The difference in sitosterol ratio between the groups remained significant after adjustment for age, BMI, fasting insulin levels, and nutritional status (P = 2 x 10(-4)), indicating a specific effect related to RYGB.	gamma-sitosterol	18-28	insulin	Homo sapiens	114-121
19937850-7	2010	Results showed that beta-sitosterol inhibits significantly vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression in TNF-alpha-stimulated HAEC as well as the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuates the phosphorylation of nuclear factor-kB p65.	gamma-sitosterol	20-35	tumor necrosis factor	Homo sapiens	140-149
19937850-7	2010	Results showed that beta-sitosterol inhibits significantly vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression in TNF-alpha-stimulated HAEC as well as the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuates the phosphorylation of nuclear factor-kB p65.	gamma-sitosterol	20-35	tumor necrosis factor	Homo sapiens	206-215
19937850-7	2010	Results showed that beta-sitosterol inhibits significantly vascular adhesion molecule 1 and intracellular adhesion molecule 1 expression in TNF-alpha-stimulated HAEC as well as the binding of U937 cells to TNF-alpha-stimulated HAEC and attenuates the phosphorylation of nuclear factor-kB p65.	gamma-sitosterol	20-35	RELA proto-oncogene, NF-kB subunit	Homo sapiens	288-291
19059205-3	2009	In this work, DU-145 cells were used to demonstrate that SPBE and its sterol components, beta-sitosterol and stigmasterol, inhibit prostate cancer growth by increasing p53 protein expression and also inhibit carcinoma development by decreasing p21 and p27 protein expression.	gamma-sitosterol	89-104	tumor protein p53	Homo sapiens	168-171
20055411-1	2010	Conjugated linoleyl beta-sitosterol (CLS) was prepared from beta-sitosterol and conjugated linoleic acid (CLA) via lipase-catalyzed synthesis in n-hexane in the presence of molecular sieves.	gamma-sitosterol	20-35	lipase, endothelial	Mus musculus	115-121
19948716-3	2010	We have now shown that (like sitosterol) sitostanol, both 4-desmethylsterols, induces a Th1 shift when added in vitro at physiological concentrations to human PBMCs.	gamma-sitosterol	29-39	negative elongation factor complex member C/D	Homo sapiens	88-91
19963159-7	2009	25Alpha-hydroxycholesterol, cholesterol, and sitosterol significantly reduced the messenger RNA (mRNA) expression of NPC1L1 and hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, whereas SR-BI mRNA was not altered by the sterols.	gamma-sitosterol	45-55	scavenger receptor class B member 1	Homo sapiens	193-198
19963159-10	2009	Sitosterol, but not stigmasterol, reduced the mRNA levels of NPC1L1 and HMG-CoA reductase to a similar extent of cholesterol.	gamma-sitosterol	0-10	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	61-67
19963159-10	2009	Sitosterol, but not stigmasterol, reduced the mRNA levels of NPC1L1 and HMG-CoA reductase to a similar extent of cholesterol.	gamma-sitosterol	0-10	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	72-89
19963159-11	2009	In conclusion, sitosterol can inhibit the expression of NPC1L1 in the enterocytes, which could be an alternate mechanism for plant sterols to reduce intestinal cholesterol uptake.	gamma-sitosterol	15-25	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	56-62
19456133-0	2009	Beta-sitosterol inhibits cell growth and induces apoptosis in SGC-7901 human stomach cancer cells.	gamma-sitosterol	0-15	sarcoglycan beta	Homo sapiens	62-65
19456133-4	2009	The results showed that beta-sitosterol suppresses the proliferation and induces the cell cytotoxicity of SGC-7901 stomach cancer cells in a time- and dose-dependent manner.	gamma-sitosterol	24-39	sarcoglycan beta	Homo sapiens	106-109
19456133-5	2009	Cells treated with different concentrations of beta-sitosterol also showed changes typical of apoptosis: morphological changes, DNA damage, increased expression of pro-caspase-3 and bax (p < 0.05), and activation of pro-caspase-3 and suppression of bcl-2 expression (p < 0.05).	gamma-sitosterol	47-62	caspase 3	Homo sapiens	164-177
19456133-5	2009	Cells treated with different concentrations of beta-sitosterol also showed changes typical of apoptosis: morphological changes, DNA damage, increased expression of pro-caspase-3 and bax (p < 0.05), and activation of pro-caspase-3 and suppression of bcl-2 expression (p < 0.05).	gamma-sitosterol	47-62	BCL2 associated X, apoptosis regulator	Homo sapiens	182-185
19456133-5	2009	Cells treated with different concentrations of beta-sitosterol also showed changes typical of apoptosis: morphological changes, DNA damage, increased expression of pro-caspase-3 and bax (p < 0.05), and activation of pro-caspase-3 and suppression of bcl-2 expression (p < 0.05).	gamma-sitosterol	47-62	caspase 3	Homo sapiens	219-232
19456133-5	2009	Cells treated with different concentrations of beta-sitosterol also showed changes typical of apoptosis: morphological changes, DNA damage, increased expression of pro-caspase-3 and bax (p < 0.05), and activation of pro-caspase-3 and suppression of bcl-2 expression (p < 0.05).	gamma-sitosterol	47-62	BCL2 apoptosis regulator	Homo sapiens	252-257
19456133-6	2009	This study therefore revealed that beta-sitosterol significantly inhibits the growth and induces the apoptosis of SGC-7901 human stomach cancer cells in vitro.	gamma-sitosterol	35-50	sarcoglycan beta	Homo sapiens	114-117
19456133-7	2009	The decrease of the bcl-2/bax ratio and DNA damage may be the critical mechanisms of apoptosis induced by beta-sitosterol in SGC-7901 human stomach cancer cells.	gamma-sitosterol	106-121	BCL2 apoptosis regulator	Homo sapiens	20-25
19456133-7	2009	The decrease of the bcl-2/bax ratio and DNA damage may be the critical mechanisms of apoptosis induced by beta-sitosterol in SGC-7901 human stomach cancer cells.	gamma-sitosterol	106-121	BCL2 associated X, apoptosis regulator	Homo sapiens	26-29
19456133-7	2009	The decrease of the bcl-2/bax ratio and DNA damage may be the critical mechanisms of apoptosis induced by beta-sitosterol in SGC-7901 human stomach cancer cells.	gamma-sitosterol	106-121	sarcoglycan beta	Homo sapiens	125-128
19059205-7	2009	The cell adhesion strength in the presence of SPBE, beta-sitosterol and cholesterol and the observation was that the increase in p53 expression triggered an increase in the intracellular force generation.	gamma-sitosterol	52-67	tumor protein p53	Homo sapiens	129-132
19963159-0	2009	Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells.	gamma-sitosterol	0-10	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	66-88
19963159-7	2009	25Alpha-hydroxycholesterol, cholesterol, and sitosterol significantly reduced the messenger RNA (mRNA) expression of NPC1L1 and hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, whereas SR-BI mRNA was not altered by the sterols.	gamma-sitosterol	45-55	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	117-123
19963159-7	2009	25Alpha-hydroxycholesterol, cholesterol, and sitosterol significantly reduced the messenger RNA (mRNA) expression of NPC1L1 and hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, whereas SR-BI mRNA was not altered by the sterols.	gamma-sitosterol	45-55	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	128-183
19207211-7	2009	We have determined that ORP3a is a bona fide sterol-binding protein with sitosterol-binding properties.	gamma-sitosterol	73-83	Oxysterol-binding family protein	Arabidopsis thaliana	24-29
19059205-3	2009	In this work, DU-145 cells were used to demonstrate that SPBE and its sterol components, beta-sitosterol and stigmasterol, inhibit prostate cancer growth by increasing p53 protein expression and also inhibit carcinoma development by decreasing p21 and p27 protein expression.	gamma-sitosterol	89-104	H3 histone pseudogene 16	Homo sapiens	244-247
19059205-3	2009	In this work, DU-145 cells were used to demonstrate that SPBE and its sterol components, beta-sitosterol and stigmasterol, inhibit prostate cancer growth by increasing p53 protein expression and also inhibit carcinoma development by decreasing p21 and p27 protein expression.	gamma-sitosterol	89-104	interferon alpha inducible protein 27	Homo sapiens	252-255
18676106-2	2008	METHODS: ICAM-1 expression was determined by immunofluorescence in HUVEC monolayers treated with LDL or oxLDL and 17beta-estradiol, progesterone or beta-sitosterol.	gamma-sitosterol	148-163	intercellular adhesion molecule 1	Homo sapiens	9-15
18445305-8	2008	We also revealed that beta-sitosterol as well as cholesterol caused apoptosis, inducing caspase-3 activity in the cells (60 % increase compared with control cells) that corresponded to the DNA fragmentation analysis in a terminal uridine deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelling (TUNEL) study.	gamma-sitosterol	22-37	caspase 3	Homo sapiens	88-97
19122149-6	2009	Upon treatment of WT mice for 3 months with the LXR agonist T2320 or for 3 weeks with beta-sitosterol, LXRalpha was downregulated, and a VP phenotype similar to that of LXRalpha(-/-) mice resulted.	gamma-sitosterol	86-101	nuclear receptor subfamily 1, group H, member 3	Mus musculus	103-111
19122149-6	2009	Upon treatment of WT mice for 3 months with the LXR agonist T2320 or for 3 weeks with beta-sitosterol, LXRalpha was downregulated, and a VP phenotype similar to that of LXRalpha(-/-) mice resulted.	gamma-sitosterol	86-101	nuclear receptor subfamily 1, group H, member 3	Mus musculus	169-177
18992226-0	2008	Beneficial effects of beta-sitosterol on glucose and lipid metabolism in L6 myotube cells are mediated by AMP-activated protein kinase.	gamma-sitosterol	22-37	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	106-134
18992226-2	2008	Beta-sitosterol, a plant sterol known to prevent cardiovascular disease was identified from Schizonepeta tenuifolia to an AMPK activator.	gamma-sitosterol	0-15	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	122-126
18992226-6	2008	Similarly, beta-sitosterol-induced phosphorylation of AMPK and ACC was not increased in HeLa cells lacking LKB1.	gamma-sitosterol	11-26	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	54-58
18992226-7	2008	These results together suggest that beta-sitosterol-mediated enhancement of glucose uptake and reduction of triglycerides and cholesterol in L6 cells is predominantly accomplished by LKB1-mediated AMPK activation.	gamma-sitosterol	36-51	serine/threonine kinase 11	Homo sapiens	183-187
18992226-7	2008	These results together suggest that beta-sitosterol-mediated enhancement of glucose uptake and reduction of triglycerides and cholesterol in L6 cells is predominantly accomplished by LKB1-mediated AMPK activation.	gamma-sitosterol	36-51	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	197-201
18676106-6	2008	RESULTS: ICAM-1 expression was inhibited by beta-sitosterol alone, when combined with 17beta-estradiol or progesterone, or with both hormones.	gamma-sitosterol	44-59	intercellular adhesion molecule 1	Homo sapiens	9-15
18676106-7	2008	It was shown that 7.5 microM beta-sitosterol decreased migration and adhesion of THP-1 cells to HUVECs cultured in the presence of oxLDL.	gamma-sitosterol	29-44	GLI family zinc finger 2	Homo sapiens	81-86
18676106-9	2008	It was shown that 7.5 microM beta-sitosterol significantly inhibited chemotaxis of [(3)H] thymidine labeled THP-1 cells in oxLDL-stimulated HUVEC cultures.	gamma-sitosterol	29-44	GLI family zinc finger 2	Homo sapiens	108-113
18676106-10	2008	MCP-1 concentrations in the supernatants of oxLDL-stimulated HUVEC cultures were inhibited by 7.5 microM beta-sitosterol as well as by progesterone and the mixture of the two female hormones.	gamma-sitosterol	105-120	C-C motif chemokine ligand 2	Homo sapiens	0-5
18314257-0	2008	beta-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.	gamma-sitosterol	0-15	BCL2 apoptosis regulator	Homo sapiens	82-87
18314257-0	2008	beta-Sitosterol induces G2/M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K/Akt signaling pathways.	gamma-sitosterol	0-15	AKT serine/threonine kinase 1	Homo sapiens	97-100
18558344-5	2008	The transformants showed increase in the content of various isoprenoids such as chlorophyll a, beta-carotene, lutein, antheraxanthin, solanesol and beta-sitosterol, indicating that the DXR reaction is one of the key steps controlling isoprenoid level in tobacco leaves.	gamma-sitosterol	148-163	1-deoxy-D-xylulose 5-phosphate reductoisomerase, chloroplastic	Nicotiana tabacum	185-188
18571124-3	2008	To illuminate the effects of sitosterol and campesterol on the development of cotton (Gossypium hirsuturm L.) fibers through screening cotton fiber EST database and contigging the candidate ESTs, two key genes GhSMT2-1 and GhSMT2-2 controlling the sitosterol biosynthesis were cloned from developing fibers of upland cotton cv.	gamma-sitosterol	29-39	24-methylenesterol C-methyltransferase 2-like	Gossypium hirsutum	210-218
18465778-3	2008	However, campesterol, beta-sitosterol and beta-sitostanol significantly suppressed mitogen-induced IL-2 production in a dose-dependent manner.	gamma-sitosterol	22-37	interleukin 2	Homo sapiens	99-103
17440528-0	2008	Basal plasma concentrations of plant sterols can predict LDL-C response to sitosterol in patients with familial hypercholesterolemia.	gamma-sitosterol	75-85	component of oligomeric golgi complex 2	Homo sapiens	57-62
17440528-0	2008	Basal plasma concentrations of plant sterols can predict LDL-C response to sitosterol in patients with familial hypercholesterolemia.	gamma-sitosterol	75-85	low density lipoprotein receptor	Homo sapiens	103-132
16935859-6	2006	In support of this hypothesis, we show here that macrophages incubated with sitosterol-containing lipoproteins accumulate free sterols and undergo death in the absence of an ACAT inhibitor.	gamma-sitosterol	76-86	carboxylesterase 1	Homo sapiens	174-178
18298899-0	2008	Beta-sitosterol sensitizes MDA-MB-231 cells to TRAIL-induced apoptosis.	gamma-sitosterol	0-15	TNF superfamily member 10	Homo sapiens	47-52
18298899-1	2008	AIM: To investigate whether subtoxic concentration of beta-sitosterol (SITO) combined with TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in TRAIL-resistant MDA-MB-231 breast cancer cells.	gamma-sitosterol	54-69	TNF superfamily member 10	Homo sapiens	158-163
17909855-0	2008	Overexpression of CYP710A1 and CYP710A4 in transgenic Arabidopsis plants increases the level of stigmasterol at the expense of sitosterol.	gamma-sitosterol	127-137	cytochrome P450, family 710, subfamily A, polypeptide 1	Arabidopsis thaliana	18-26
17909855-0	2008	Overexpression of CYP710A1 and CYP710A4 in transgenic Arabidopsis plants increases the level of stigmasterol at the expense of sitosterol.	gamma-sitosterol	127-137	cytochrome P450, family 710, subfamily A, polypeptide 4	Arabidopsis thaliana	31-39
17960447-6	2007	The efflux of beta-sitosterol and sitostanol from preloaded THP-1 cells to HDL was more efficient than the efflux of campesterol and cholesterol (rate constants of 0.41 +/- 0.04/h, 0.62 +/- 0.08/h, 0.23 +/- 0.05/h and 0.29 +/- 0.03/h, respectively).	gamma-sitosterol	14-29	GLI family zinc finger 2	Homo sapiens	60-65
17885082-5	2007	Taking a transgenic approach, we showed that Arabidopsis seeds overexpressing AtSAT1 accumulated fatty acyl esters of cycloartenol, accompanied by substantial decreases in ester content of campesterol and beta-sitosterol.	gamma-sitosterol	205-220	serine acetyltransferase 2;1	Arabidopsis thaliana	78-84
17570321-0	2007	Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.	gamma-sitosterol	0-15	mitogen-activated protein kinase 1	Mus musculus	67-70
17570321-0	2007	Beta-sitosterol-induced-apoptosis is mediated by the activation of ERK and the downregulation of Akt in MCA-102 murine fibrosarcoma cells.	gamma-sitosterol	0-15	thymoma viral proto-oncogene 1	Mus musculus	97-100
17603173-0	2007	Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	0-15	caspase 3	Homo sapiens	108-117
17603173-0	2007	Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	0-15	BCL2 associated X, apoptosis regulator	Homo sapiens	135-138
17603173-0	2007	Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	0-15	BCL2 apoptosis regulator	Homo sapiens	139-144
17603173-5	2007	The increase in apoptosis induced by beta-sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3.	gamma-sitosterol	37-52	BCL2 apoptosis regulator	Homo sapiens	92-97
17603173-5	2007	The increase in apoptosis induced by beta-sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3.	gamma-sitosterol	37-52	poly(ADP-ribose) polymerase 1	Homo sapiens	114-142
17603173-5	2007	The increase in apoptosis induced by beta-sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3.	gamma-sitosterol	37-52	poly(ADP-ribose) polymerase 1	Homo sapiens	144-148
17603173-5	2007	The increase in apoptosis induced by beta-sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3.	gamma-sitosterol	37-52	phospholipase C gamma 1	Homo sapiens	154-182
17603173-5	2007	The increase in apoptosis induced by beta-sitosterol was associated with down-regulation of Bcl-2, degradation of poly-(ADP-ribose) polymerase (PARP) and phospholipase C (PLC)-gamma1 protein, and activation of caspase-3.	gamma-sitosterol	37-52	caspase 3	Homo sapiens	210-219
17603173-7	2007	z-DEVD-fmk, a caspase-3 specific inhibitor, blocked caspase-3 activation and PARP degradation, and significantly attenuated beta-sitosterol-induced apoptosis.	gamma-sitosterol	124-139	caspase 3	Homo sapiens	14-23
17603173-8	2007	This suggests that caspase-3 activation is partially essential for beta-sitosterol-induced apoptosis.	gamma-sitosterol	67-82	caspase 3	Homo sapiens	19-28
17603173-9	2007	Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by beta-sitosterol, and effectively attenuated the apoptotic response to beta-sitosterol.	gamma-sitosterol	106-121	BCL2 apoptosis regulator	Homo sapiens	0-5
17603173-9	2007	Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by beta-sitosterol, and effectively attenuated the apoptotic response to beta-sitosterol.	gamma-sitosterol	106-121	poly(ADP-ribose) polymerase 1	Homo sapiens	89-93
17603173-9	2007	Bcl-2 overexpression also significantly blocked caspase-3 activation and the decrease in PARP cleavage by beta-sitosterol, and effectively attenuated the apoptotic response to beta-sitosterol.	gamma-sitosterol	176-191	BCL2 apoptosis regulator	Homo sapiens	0-5
17603173-10	2007	These results show that beta-sitosterol potently induces apoptosis in U937 cells and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	90-105	caspase 3	Homo sapiens	166-175
17603173-10	2007	These results show that beta-sitosterol potently induces apoptosis in U937 cells and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	90-105	BCL2 associated X, apoptosis regulator	Homo sapiens	193-196
17603173-10	2007	These results show that beta-sitosterol potently induces apoptosis in U937 cells and that beta-sitosterol-induced apoptosis is related to the selective activation of caspase-3 and induction of Bax/Bcl-2 ratio.	gamma-sitosterol	90-105	BCL2 apoptosis regulator	Homo sapiens	197-202
17029589-10	2007	Paclitaxel-stimulated ATPase activity of MDR1 is enhanced in the presence of stigmasterol, sitosterol and campesterol, as well as cholesterol, but not ergosterol.	gamma-sitosterol	91-101	dynein axonemal heavy chain 8	Homo sapiens	22-28
17029589-10	2007	Paclitaxel-stimulated ATPase activity of MDR1 is enhanced in the presence of stigmasterol, sitosterol and campesterol, as well as cholesterol, but not ergosterol.	gamma-sitosterol	91-101	ATP binding cassette subfamily B member 1	Homo sapiens	41-45
17102949-0	2007	Sitosterol and cholesterol in chylomicrons of type 2 diabetic and non-diabetic subjects: the relationship with ATP binding cassette proteins G5 and G8 and Niemann-Pick C1-like 1 mRNA.	gamma-sitosterol	0-10	G-patch domain and ankyrin repeats 1	Homo sapiens	141-150
16935859-0	2006	Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages.	gamma-sitosterol	0-10	carboxylesterase 1	Homo sapiens	92-96
18310900-2	2008	Although orally administered beta-sitosterol (4 micromol as beta-sitosterol/mouse) was not absorbed into plasma, the amount of immune response cytokines such as IL-12 and IL-18 was increased in the small intestine after the liposome intake.	gamma-sitosterol	29-44	interleukin 18	Mus musculus	171-176
18319397-6	2008	IPP isomerase activity in the cytosol was confirmed by uniform labeling of IPP- and DMAPP-derived units of the cytoplasmic isoprenoid product, sitosterol, when labeled mevalonate was administered.	gamma-sitosterol	143-153	isopentenyl diphosphate isomerase 1	Arabidopsis thaliana	0-13
18238900-0	2008	Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson"s dementia.	gamma-sitosterol	48-63	nuclear receptor subfamily 1, group H, member 2	Mus musculus	0-21
18238900-0	2008	Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson"s dementia.	gamma-sitosterol	48-63	nuclear receptor subfamily 1, group H, member 2	Mus musculus	23-30
18238900-1	2008	Administration of beta-sitosterol (42 mg/kg per day) for 3 weeks to 8-month-old male LXRbeta-/- mice resulted in the death of motor neurons in the lumbar region of the spinal cord and loss of tyrosine hydroxylase-positive dopaminergic neurons in the substantia nigra.	gamma-sitosterol	18-33	nuclear receptor subfamily 1, group H, member 2	Mus musculus	85-92
18238900-2	2008	In mice at 5 months of age, beta-sitosterol had no observed toxicity but at 16 months of age, it caused severe paralysis and symptoms typical of dopaminergic dysfunction in LXRbeta-/- mice.	gamma-sitosterol	28-43	nuclear receptor subfamily 1, group H, member 2	Mus musculus	173-180
18238900-6	2008	Brain cholesterol concentrations were higher in LXRbeta-/- than in their WT counterparts, and treatment with beta-sitosterol reduced brain cholesterol in both WT and LXRbeta-/- mice.	gamma-sitosterol	109-124	nuclear receptor subfamily 1, group H, member 2	Mus musculus	166-173
18238900-7	2008	In LXRbeta-/- mice but not in WT mice levels of 24-hydrocholesterol were increased upon beta-sitosterol treatment.	gamma-sitosterol	88-103	nuclear receptor subfamily 1, group H, member 2	Mus musculus	3-10
18238900-8	2008	These data indicate that multiple mechanisms are involved in the sensitivity of LXRbeta-/- mice to beta-sitosterol.	gamma-sitosterol	99-114	nuclear receptor subfamily 1, group H, member 2	Mus musculus	80-87
17920528-0	2007	Effects of lactose-beta-sitosterol and beta-sitosterol on ovalbumin-induced lung inflammation in actively sensitized mice.	gamma-sitosterol	39-54	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	58-67
17573060-4	2007	Leptin was associated with synthesis markers (e.g. desmosterol r=0.271, P<0.05) and negatively with absorption markers (e.g. sitosterol r=-0.278, P<0.05).	gamma-sitosterol	128-138	leptin	Homo sapiens	0-6
17135346-0	2007	Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells.	gamma-sitosterol	86-101	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	0-22
17135346-5	2007	It was also demonstrated that the uptakes of both cholesterol and beta-sitosterol are increased by NPC1L1 overexpression.	gamma-sitosterol	66-81	NPC1 like intracellular cholesterol transporter 1	Homo sapiens	99-105
15860443-13	2005	beta-sitosterol reduced the levels of cyclin B1 and cdc2 while increasing p21waf1/cip1 in both the premalignant and malignant cell lines.	gamma-sitosterol	0-15	cyclin B1	Homo sapiens	38-47
16500904-9	2006	Beta-sitosterol and campesterol showed similar inhibitory effects but stigmasterol did not, suggesting structure-specific interaction between ABCA1 and sterols.	gamma-sitosterol	0-15	ATP binding cassette subfamily A member 1	Homo sapiens	142-147
16677856-7	2006	Moreover, sitosterol upregulated apoE mRNA and protein levels in astrocytoma, but not in neuroblastoma cells, to a higher extend than cholesterol.	gamma-sitosterol	10-20	apolipoprotein E	Mus musculus	33-37
16460510-9	2006	Cholesterol (C27 sterol) is the best substrate, followed by CR (C28 sterol), whereas sitosterol (C29 sterol) is a poor substrate, suggesting that the substrate preference of CYP90B1 may explain the discrepancy between the in planta abundance of C27/C28/C29 sterols and C27/C28/C29 BRs.	gamma-sitosterol	85-95	Cytochrome P450 superfamily protein	Arabidopsis thaliana	174-181
15992359-4	2005	In the presence of cholesterol, ACAT1-mediated esterification of sitosterol is highly activated while ACAT2-mediated esterification of sitosterol is only moderately activated.	gamma-sitosterol	65-75	acetyl-CoA acetyltransferase 1	Homo sapiens	32-37
15992359-4	2005	In the presence of cholesterol, ACAT1-mediated esterification of sitosterol is highly activated while ACAT2-mediated esterification of sitosterol is only moderately activated.	gamma-sitosterol	135-145	acetyl-CoA acetyltransferase 2	Homo sapiens	102-107
15992359-8	2005	To demonstrate the relevance of the ACAT1 allosteric model in intact cells, we showed that sitosterol esterification in human macrophages is activated upon cholesterol loading.	gamma-sitosterol	91-101	acetyl-CoA acetyltransferase 1	Homo sapiens	36-41
15816807-3	2005	In the present study, we tested the hypothesis that genetic variation in ABCG5/ABCG8 influences the levels of serum plant sterol (sitosterol) and cholesterol precursor (lathosterol) in Japanese primary hypercholesterolaemic patients (n = 100).	gamma-sitosterol	130-140	ATP binding cassette subfamily G member 5	Homo sapiens	73-78
15816807-3	2005	In the present study, we tested the hypothesis that genetic variation in ABCG5/ABCG8 influences the levels of serum plant sterol (sitosterol) and cholesterol precursor (lathosterol) in Japanese primary hypercholesterolaemic patients (n = 100).	gamma-sitosterol	130-140	ATP binding cassette subfamily G member 8	Homo sapiens	79-84
15867948-3	2005	The cholesterol lowering properties of plant sterols have been known for some time and many clinical studies have confirmed the efficacy of sitosterol in lowering plasma LDL-C concentrations.	gamma-sitosterol	140-150	component of oligomeric golgi complex 2	Homo sapiens	170-175
15867948-8	2005	Compared to cholesterol and other sterols, sitosterol is preferentially pumped out to the intestinal lumen by the ABCG5/8 transporters.	gamma-sitosterol	43-53	ATP binding cassette subfamily G member 5	Homo sapiens	114-121
15520451-4	2005	Cholesterol-standardized serum campesterol and sitosterol concentrations were significantly associated with the ABCG8 T400K genotype, as were changes in serum plant sterol concentrations after consumption of plant stanols.	gamma-sitosterol	47-57	ATP binding cassette subfamily G member 8	Homo sapiens	112-117
17199997-7	2006	Confocal microscopy showed an abnormal microtubular network in SiHa cell treated with beta-sitosterol for 5 days, and the expression of microtubule associated protein 2 was marked down-regulated.	gamma-sitosterol	86-101	microtubule associated protein 2	Homo sapiens	136-168
17199997-8	2006	Further analysis by immunoblotting confirmed the down-regulation of beta-sitosterol on the expression for both microtubule associated protein 2 and tubulin alpha.	gamma-sitosterol	68-83	microtubule associated protein 2	Homo sapiens	111-143
17199997-10	2006	CONCLUSION: beta-sitosterol could down-regulate the expression of tubulin alpha and microtubule associated protein 2 in SiHa cells, and inhibit the microtubular polymerization.	gamma-sitosterol	12-27	microtubule associated protein 2	Homo sapiens	84-116
16199524-5	2005	Inactivation of residual endogenous synthesis with the squalene epoxidase inhibitor NB-598 prevented growth in beta-sitosterol and greatly reduced growth in campesterol.	gamma-sitosterol	111-126	squalene epoxidase	Homo sapiens	55-73
16115472-10	2005	Secretion of apoB48 from intestinal cells significantly decreased by 15% with stigmasterol, 16% with campesterol and 19% beta-sitosterol compared to control.	gamma-sitosterol	121-136	apolipoprotein B	Homo sapiens	13-19
16040657-8	2005	Measurements of endogenous sterol levels in the cyp51A2 mutant revealed that it accumulates obtusifoliol, the substrate of CYP51, and a high proportion of 14alpha-methyl-delta8-sterols, at the expense of campesterol and sitosterol.	gamma-sitosterol	220-230	CYTOCHROME P450 51G1	Arabidopsis thaliana	48-55
15860443-13	2005	beta-sitosterol reduced the levels of cyclin B1 and cdc2 while increasing p21waf1/cip1 in both the premalignant and malignant cell lines.	gamma-sitosterol	0-15	cyclin dependent kinase 1	Homo sapiens	52-56
15860443-13	2005	beta-sitosterol reduced the levels of cyclin B1 and cdc2 while increasing p21waf1/cip1 in both the premalignant and malignant cell lines.	gamma-sitosterol	0-15	cyclin dependent kinase inhibitor 1A	Homo sapiens	74-86
15860444-6	2005	beta-sitosterol and stigmasterol increased the level of connexin43 protein (Cx43) and restored phosphorylation of Cx43 to levels similar to the parental nontransfected cell line.	gamma-sitosterol	0-15	gap junction protein, alpha 1	Rattus norvegicus	56-66
15860444-6	2005	beta-sitosterol and stigmasterol increased the level of connexin43 protein (Cx43) and restored phosphorylation of Cx43 to levels similar to the parental nontransfected cell line.	gamma-sitosterol	0-15	gap junction protein, alpha 1	Rattus norvegicus	76-80
15860444-6	2005	beta-sitosterol and stigmasterol increased the level of connexin43 protein (Cx43) and restored phosphorylation of Cx43 to levels similar to the parental nontransfected cell line.	gamma-sitosterol	0-15	gap junction protein, alpha 1	Rattus norvegicus	114-118
15582018-3	2004	Further activity-guided fractionation of fraction C led to the isolation of an anti-inflammatory principle, CS-1, identified as sitosterol.	gamma-sitosterol	128-138	catalase	Rattus norvegicus	108-112
15331430-3	2004	Relative to the wild-type (400TT), subjects carrying the ABCG8 400K allele had significantly decreased plasma concentrations of triglycerides, sitosterol, and campesterol, lower PR of VLDL-apoB, and higher VLDL to LDL-apoB conversion (P<0.05).	gamma-sitosterol	143-153	ATP binding cassette subfamily G member 8	Homo sapiens	57-62
15331430-7	2004	During multiple regression analysis including age, homeostasis model assessment score, plasma concentrations of sitosterol, and lathosterol, ABCG8 and apoE genotypes were independent determinants of VLDL-apoB PR and LDL-apoB FCR, respectively (P<0.05).	gamma-sitosterol	112-122	apolipoprotein B	Homo sapiens	204-208
14993242-7	2004	Similar to results observed with intestinal ABCA1-facilitated cholesterol efflux, LXR/RXR ligand activation enhanced the basolateral efflux of beta-sitosterol without affecting apical efflux.	gamma-sitosterol	143-158	retinoid X receptor alpha	Homo sapiens	86-89
15173162-3	2004	NPC1L1 null mice had substantially reduced intestinal uptake of cholesterol and sitosterol, with dramatically reduced plasma phytosterol levels.	gamma-sitosterol	80-90	NPC1 like intracellular cholesterol transporter 1	Mus musculus	0-6
15246101-2	2004	Bioassay-guided fractionation of these extracts led to the isolation of three DNA polymerase beta lyase inhibitory phytosterols, namely stigmasterol (1) and beta-sitosterol (2), isolated from the hexanes extracts, and beta-sitosterol-beta-d-glucoside (3), isolated from the methyl ethyl ketone extract.	gamma-sitosterol	157-172	DNA polymerase beta	Homo sapiens	78-97
14993242-0	2004	LXR/RXR ligand activation enhances basolateral efflux of beta-sitosterol in CaCo-2 cells.	gamma-sitosterol	57-72	retinoid X receptor alpha	Homo sapiens	4-7
14993242-1	2004	To examine whether intestinal ABCA1 was responsible for the differences observed between cholesterol and beta-sitosterol absorption, ABCA1-facilitated beta-sitosterol efflux was investigated in CaCo-2 cells following liver X receptor/retinoid X receptor (LXR/RXR) activation.	gamma-sitosterol	151-166	ATP binding cassette subfamily A member 1	Homo sapiens	133-138
15309453-5	2004	RESULTS: From the end of the stabilization diet period to the end of the supplementation with the soy protein product with added beta-sitosterol we observed a 19.64 +/- 20.32 mg/dL, 8.47 +/- 54.61 mg/dL, 1.69 +/- 10.92 mg/dL, and 7.06 +/- 16.66 mg/dL mean +/- SD decrease respectively in LDL-C (p < 0.001), TG (p = 0.358), VLDLs (p = 0.358) and apoB (p = 0.016) levels, associated with a 1.31 +/- 8.08 mg/dL and 1.03 +/- 19.09 mg/dL mean increase respectively in HDLC (p = 0.251) and apoAI (p = 0.749) plasma concentrations.	gamma-sitosterol	129-144	apolipoprotein B	Homo sapiens	348-352
15175352-4	2004	The 604E allele of the ABCG5 gene in men was associated with high BMI, plasma insulin, low serum sitosterol, and high serum cholestenol levels (P < 0.05 for all).	gamma-sitosterol	97-107	ATP binding cassette subfamily G member 5	Homo sapiens	23-28
14993242-2	2004	Both the LXR agonist T0901317 and the natural RXR/LXR agonists 22-hydroxycholesterol and 9-cis retinoic acid enhanced the basolateral efflux of beta-sitosterol without altering apical efflux.	gamma-sitosterol	144-159	retinoid X receptor alpha	Homo sapiens	46-49
14993242-9	2004	ABCA1, however, may play a role in beta-sitosterol absorption.	gamma-sitosterol	35-50	ATP binding cassette subfamily A member 1	Homo sapiens	0-5
15040800-7	2004	RESULTS: Mice deficient in Abcg8 have significantly increased plasma and tissue plant sterol levels (sitosterol and campesterol) consistent with sitosterolemia.	gamma-sitosterol	101-111	ATP binding cassette subfamily G member 8	Mus musculus	27-32
15040800-9	2004	Remarkably, Abcg8 deficient mice had an impaired ability to secrete cholesterol into bile, but still maintained the ability to secrete sitosterol.	gamma-sitosterol	135-145	ATP binding cassette subfamily G member 8	Mus musculus	12-17
15040800-11	2004	CONCLUSION: These data indicate that Abcg8/sterolin-2 is necessary for biliary sterol secretion and that loss of Abcg8/sterolin-2 has a more profound effect upon biliary cholesterol secretion than sitosterol.	gamma-sitosterol	197-207	ATP binding cassette subfamily G member 8	Mus musculus	113-118
12579296-0	2003	Beta-sitosterol, a plant sterol, induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells.	gamma-sitosterol	0-15	caspase 8	Homo sapiens	69-77
14699507-5	2004	Retention of orally administered [(3)H]beta-sitosterol in the intestinal wall (+550%) and plasma (+640%) was higher in Abcg5-null mice than in wild-type controls.	gamma-sitosterol	39-54	ATP binding cassette subfamily G member 5	Mus musculus	119-124
14699507-6	2004	Surprisingly, high plasma beta-sitosterol and campesterol concentrations were even further elevated in Abcg5-null mice on treatment with the synthetic LXR agonist T0901317 (0.015% dietary supplementation, 10 days), whereas these concentrations were reduced by approximately 75% in wild-type mice.	gamma-sitosterol	26-41	ATP binding cassette subfamily G member 5	Mus musculus	103-108
12975367-5	2003	Compared with ACAT1, ACAT2 selectively esterified cholesterol even when sitosterol was loaded into the microsomes.	gamma-sitosterol	72-82	acetyl-CoA acetyltransferase 2	Homo sapiens	21-26
12975367-7	2003	Despite a lower level of ACAT activity, the ACAT1-expressing cells esterified 4-fold more sitosterol than the ACAT2 cells.	gamma-sitosterol	90-100	acetyl-CoA acetyltransferase 1	Homo sapiens	44-49
12975367-8	2003	The data showed that compared with ACAT1, ACAT2 displayed significantly greater selectively for cholesterol compared with sitosterol.	gamma-sitosterol	122-132	acetyl-CoA acetyltransferase 1	Homo sapiens	35-40
12975367-11	2003	Thus, LCAT was able to efficiently esterify both cholesterol and sitosterol.	gamma-sitosterol	65-75	lecithin-cholesterol acyltransferase	Homo sapiens	6-10
12975367-12	2003	In contrast, ACAT2 demonstrated a strong preference for cholesterol rather than sitosterol.	gamma-sitosterol	80-90	acetyl-CoA acetyltransferase 2	Homo sapiens	13-18
14699507-4	2004	RESULTS: Abcg5 deficiency was associated with strongly elevated plasma levels of beta-sitosterol (37-fold) and campesterol (7.7-fold) as well as reduced plasma cholesterol concentrations (-40%).	gamma-sitosterol	81-96	ATP binding cassette subfamily G member 5	Mus musculus	9-14
14612938-0	2003	Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells.	gamma-sitosterol	51-66	BCL2 associated X, apoptosis regulator	Homo sapiens	13-16
14612938-0	2003	Induction of Bax and activation of caspases during beta-sitosterol-mediated apoptosis in human colon cancer cells.	gamma-sitosterol	51-66	caspase 9	Homo sapiens	35-43
14612938-4	2003	Apoptosis-inducing concentrations of beta-sitosterol induced caspase-3 and caspase-9 activation accompanied by proteolytic cleavage of poly(ADP-ribose)-polymerase.	gamma-sitosterol	37-52	caspase 3	Homo sapiens	61-70
14612938-4	2003	Apoptosis-inducing concentrations of beta-sitosterol induced caspase-3 and caspase-9 activation accompanied by proteolytic cleavage of poly(ADP-ribose)-polymerase.	gamma-sitosterol	37-52	caspase 9	Homo sapiens	75-84
14612938-4	2003	Apoptosis-inducing concentrations of beta-sitosterol induced caspase-3 and caspase-9 activation accompanied by proteolytic cleavage of poly(ADP-ribose)-polymerase.	gamma-sitosterol	37-52	poly(ADP-ribose) polymerase 1	Homo sapiens	135-162
14612938-5	2003	In addition, beta-sitosterol-induced apoptosis in HT116 cells was associated with a decreased expression of the anti-apototic Bcl-2 protein and mRNA and a concomitant increase of the pro-apototic Bax protein and mRNA, and with release of cytochrome c from the mitochondria into the cytosol.	gamma-sitosterol	13-28	BCL2 apoptosis regulator	Homo sapiens	126-131
14612938-5	2003	In addition, beta-sitosterol-induced apoptosis in HT116 cells was associated with a decreased expression of the anti-apototic Bcl-2 protein and mRNA and a concomitant increase of the pro-apototic Bax protein and mRNA, and with release of cytochrome c from the mitochondria into the cytosol.	gamma-sitosterol	13-28	BCL2 associated X, apoptosis regulator	Homo sapiens	196-199
14612938-5	2003	In addition, beta-sitosterol-induced apoptosis in HT116 cells was associated with a decreased expression of the anti-apototic Bcl-2 protein and mRNA and a concomitant increase of the pro-apototic Bax protein and mRNA, and with release of cytochrome c from the mitochondria into the cytosol.	gamma-sitosterol	13-28	cytochrome c, somatic	Homo sapiens	238-250
14612938-6	2003	beta-sitosterol treatment also inhibited the expression of cIAP-1 without significant changes in the level of cIAP-2.	gamma-sitosterol	0-15	baculoviral IAP repeat containing 2	Homo sapiens	59-65
12975367-0	2003	Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.	gamma-sitosterol	175-185	acetyl-CoA acetyltransferase 1	Homo sapiens	14-61
12975367-0	2003	Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.	gamma-sitosterol	175-185	lecithin-cholesterol acyltransferase	Homo sapiens	66-102
12975367-0	2003	Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol.	gamma-sitosterol	175-185	acetyl-CoA acetyltransferase 2	Homo sapiens	104-109
12975367-1	2003	The capacity of acyl-CoA:cholesterol O-acyltransferase (ACAT) 2 to differentiate cholesterol from the plant sterol, sitosterol, was compared with that of the sterol esterifying enzymes, ACAT1 and lecithin:cholesterol acyltransferase (LCAT).	gamma-sitosterol	116-126	acetyl-CoA acetyltransferase 1	Homo sapiens	16-54
12975367-1	2003	The capacity of acyl-CoA:cholesterol O-acyltransferase (ACAT) 2 to differentiate cholesterol from the plant sterol, sitosterol, was compared with that of the sterol esterifying enzymes, ACAT1 and lecithin:cholesterol acyltransferase (LCAT).	gamma-sitosterol	116-126	acetyl-CoA acetyltransferase 1	Homo sapiens	56-60
12975367-3	2003	In sitosterol-loaded microsomes, both ACAT1 and ACAT2 were able to esterify sitosterol albeit with lower efficiencies than cholesterol.	gamma-sitosterol	3-13	acetyl-CoA acetyltransferase 1	Homo sapiens	38-43
12975367-3	2003	In sitosterol-loaded microsomes, both ACAT1 and ACAT2 were able to esterify sitosterol albeit with lower efficiencies than cholesterol.	gamma-sitosterol	3-13	acetyl-CoA acetyltransferase 2	Homo sapiens	48-53
12975367-3	2003	In sitosterol-loaded microsomes, both ACAT1 and ACAT2 were able to esterify sitosterol albeit with lower efficiencies than cholesterol.	gamma-sitosterol	76-86	acetyl-CoA acetyltransferase 1	Homo sapiens	38-43
12975367-3	2003	In sitosterol-loaded microsomes, both ACAT1 and ACAT2 were able to esterify sitosterol albeit with lower efficiencies than cholesterol.	gamma-sitosterol	76-86	acetyl-CoA acetyltransferase 2	Homo sapiens	48-53
14613201-9	2003	The effect on ABCA1 and ApoAI expression was even stronger (5.7- and 2.6-fold, respectively) with beta-sitosterol-containing micelles.	gamma-sitosterol	98-113	ATP binding cassette subfamily A member 1	Homo sapiens	14-19
14613201-9	2003	The effect on ABCA1 and ApoAI expression was even stronger (5.7- and 2.6-fold, respectively) with beta-sitosterol-containing micelles.	gamma-sitosterol	98-113	apolipoprotein A1	Homo sapiens	24-29
14613201-10	2003	Similar changes are in line with previous findings and suggest that the short incubation with beta-sitosterol-enriched micelles stimulates a specific mechanism that, via ABCA1 activation, can increase the cholesterol and phytosterol basolateral efflux.	gamma-sitosterol	94-109	ATP binding cassette subfamily A member 1	Homo sapiens	170-175
12579296-4	2003	The results of the present study indicate that beta-sitosterol supplementation at 16 microM for 3 days to MDA-MB-231 cells induces 39% and 80% increases in the activities of caspases 8 and 9, respectively, compared to cholesterol supplemented cells or controls.	gamma-sitosterol	47-62	caspase 8	Homo sapiens	174-190
12427790-1	2002	BACKGROUND: Recently identified ABCG5/8 transporters are responsible in part for the different absorption rates of campesterol, sitosterol, and cholesterol.	gamma-sitosterol	128-138	ATP binding cassette subfamily G member 5	Homo sapiens	32-37
12628205-8	2003	This multigeneration test evidenced that phytosterols containing -sitosterol disrupt the reproduction system of zebrafish by changing the sex ratios and by inducing the vitellogenin production in the exposed fish.	gamma-sitosterol	66-76	vitellogenin	Danio rerio	169-181
12427790-10	2002	CONCLUSION: The observed inverse relation between hepatic clearance and known intestinal absorption of cholesterol, campesterol, and sitosterol supports the hypothesis that the ABCG5/8 transporters regulating intestinal sterol absorption might also be involved in biliary sterol excretion.	gamma-sitosterol	133-143	ATP binding cassette subfamily G member 5	Homo sapiens	177-182
11962251-8	2001	beta-Sitosterol inhibited tumor cell invasion through Matrigel and adhesion of cells to plates coated with collagen I, collagen IV, fibronectin, and laminin compared with cholesterol treatments and controls.	gamma-sitosterol	0-15	fibronectin 1	Homo sapiens	132-143
11726725-6	2001	The 16 apoE4 children had 30% to 50% higher cholesterol-adjusted campesterol and sitosterol concentrations in serum than the 20 apoE 3/3 children (p = 0.002 and p = 0.02, respectively).	gamma-sitosterol	81-91	apolipoprotein E	Homo sapiens	7-12
11726725-6	2001	The 16 apoE4 children had 30% to 50% higher cholesterol-adjusted campesterol and sitosterol concentrations in serum than the 20 apoE 3/3 children (p = 0.002 and p = 0.02, respectively).	gamma-sitosterol	81-91	apolipoprotein E	Homo sapiens	7-11
11319028-0	2001	The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1.	gamma-sitosterol	28-38	methyltransferase 1	Arabidopsis thaliana	100-119
12232266-9	1994	In contrast to the specificity with regard to the glycosyl donor, UDPG-SGTase utilized all tested sterol acceptors, such as [beta]-sitosterol, cholesterol, stigmasterol, and ergosterol.	gamma-sitosterol	124-141	UDP-glucose pyrophosphorylase 2	Homo sapiens	66-70
10763582-7	2000	Compounds 5 (beta-sitosterol) and 6 (daucosterine), especially 5, completely blocked such an increased activation of PTK induced by H/R.	gamma-sitosterol	13-28	EPH receptor A8	Homo sapiens	117-120
10695663-0	2000	3-Hydroxy-3-methylglutaryl-coenzyme A reductase activity is inhibited by cholesterol and up-regulated by sitosterol in sitosterolemic fibroblasts.	gamma-sitosterol	105-115	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	0-47
10695663-4	2000	It is still controversial whether the down-regulation is due to accumulated sitosterol, but the effect of sitosterol on HMG-CoA reductase activity has not been studied in sitosterolemic tissues.	gamma-sitosterol	106-116	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	120-137
10695663-5	2000	To investigate whether sitosterol inhibits HMG-CoA reductase activity in sitosterolemia, we measured the enzyme activities in liver and cultured skin flbroblasts from patients.	gamma-sitosterol	23-33	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	43-60
10695663-9	2000	Raising the intracellular sitosterol concentration to 7% of cellular cholesterol level increased HMG-CoA reductase activity 23% (P < .05), while the addition of the same amount of cholesterol to the cells reduced the activity 46% (P < .05).	gamma-sitosterol	26-36	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	97-114
10695663-10	2000	Thus, when sitosterolemic skin fibroblasts were used, it was possible to distinguish between the effects of cholesterol and those of sitosterol on the activity of HMG-CoA reductase.	gamma-sitosterol	11-21	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	163-180
10695663-11	2000	These results suggest that reduced HMG-CoA reductase activity in this disease is caused by secondary effects of unknown regulator(s) other than sitosterol.	gamma-sitosterol	144-154	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	35-52
10798219-0	2000	Effect of beta-sitosterol, a plant sterol, on growth, protein phosphatase 2A, and phospholipase D in LNCaP cells.	gamma-sitosterol	10-25	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	82-97
9756854-2	1998	A recombinant StAR protein lacking the first N-terminal 62 amino acid residues that includes the mitochondrial targeting sequence was shown to stimulate the transfer of cholesterol and beta-sitosterol from liposomes to heat-treated mitochondria in a dose-, time-, and temperature-dependent manner.	gamma-sitosterol	185-200	steroidogenic acute regulatory protein	Homo sapiens	14-18
9460081-0	1998	Competitive inhibition of hepatic sterol 27-hydroxylase by sitosterol: decreased activity in sitosterolemia.	gamma-sitosterol	59-69	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	34-55
9460081-1	1998	We investigated the effect of sitosterol on hepatic sterol 27-hydroxylase activities in subjects with sitosterolemia, a recessive inherited disease associated with accelerated atherosclerosis and increased levels of sitosterol and other plant sterols and stanols in tissues.	gamma-sitosterol	30-40	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	52-73
9460081-1	1998	We investigated the effect of sitosterol on hepatic sterol 27-hydroxylase activities in subjects with sitosterolemia, a recessive inherited disease associated with accelerated atherosclerosis and increased levels of sitosterol and other plant sterols and stanols in tissues.	gamma-sitosterol	102-112	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	52-73
9460081-9	1998	Thus, decreased cholesterol catabolism due to competitive inhibition of both microsomal cholesterol 7 alpha-hydroxylase and mitochondrial sterol 27-hydroxylase by elevated hepatic sitosterol concentrations contributes to hypercholesterolemia and increased risk of atherosclerosis in sitosterolemia.	gamma-sitosterol	180-190	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	88-119
9460081-9	1998	Thus, decreased cholesterol catabolism due to competitive inhibition of both microsomal cholesterol 7 alpha-hydroxylase and mitochondrial sterol 27-hydroxylase by elevated hepatic sitosterol concentrations contributes to hypercholesterolemia and increased risk of atherosclerosis in sitosterolemia.	gamma-sitosterol	180-190	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	138-159
8619247-9	1996	Wood-derived compounds such as beta-sitosterol, present in pulp and paper mill effluents, may account for the weak estrogenicity of debarking effluent seen at the vitellogenin expression bioassay.	gamma-sitosterol	31-46	LOC100136735	Oncorhynchus mykiss	163-175
7852865-11	1994	Bile acid malabsorption after ileal bypass surgery stimulated cholesterol 7 alpha-hydroxylase activity 78% in sitosterolemic whole liver microsomes and reduced plasma cholesterol, sitosterol, and cholestanol levels 61%, 55% and 91%, respectively, producing a pronounced decrease in the cholestanol/cholesterol ratio without changing the sitosterol/cholesterol ratio.	gamma-sitosterol	110-120	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	62-93
10828677-3	2000	The purpose of this study was to investigate the effect of beta-sitosterol on the expression of transforming growth factor beta 1 (TGF-beta1) and the activity of protein kinase C alpha (PKC-alpha) in primary prostate stromal cell cultures in vitro.	gamma-sitosterol	59-74	transforming growth factor beta 1	Homo sapiens	96-129
10828677-3	2000	The purpose of this study was to investigate the effect of beta-sitosterol on the expression of transforming growth factor beta 1 (TGF-beta1) and the activity of protein kinase C alpha (PKC-alpha) in primary prostate stromal cell cultures in vitro.	gamma-sitosterol	59-74	transforming growth factor beta 1	Homo sapiens	131-140
10828677-5	2000	TGF-beta1 levels in stromal cell conditioned media following a culture with beta-sitosterol were detected in a TGF-beta1 specific ELISA assay.	gamma-sitosterol	76-91	transforming growth factor beta 1	Homo sapiens	0-9
10828677-5	2000	TGF-beta1 levels in stromal cell conditioned media following a culture with beta-sitosterol were detected in a TGF-beta1 specific ELISA assay.	gamma-sitosterol	76-91	transforming growth factor beta 1	Homo sapiens	111-120
10828677-8	2000	RESULTS: Beta-sitosterol was able to induce the expression and secretion of TGF-beta1 significantly between 1.26- and 1.86-fold compared to a cholesterol and the nonsupplemented control in 6 of 8 individual cultures.	gamma-sitosterol	9-24	transforming growth factor beta 1	Homo sapiens	76-85
10828677-12	2000	Following a culture with beta-sitosterol, a translocation of PKC-alpha from the membrane to the cytosol was observed.	gamma-sitosterol	25-40	protein kinase C alpha	Homo sapiens	61-70
10828677-14	2000	CONCLUSION: This study describes the effect of beta-sitosterol on the expression of a multifunctional growth factor (TGF-beta1) and the activity of PKC-alpha membrane in stromal cells of the human prostate in vitro.	gamma-sitosterol	47-62	transforming growth factor beta 1	Homo sapiens	117-126
10828677-14	2000	CONCLUSION: This study describes the effect of beta-sitosterol on the expression of a multifunctional growth factor (TGF-beta1) and the activity of PKC-alpha membrane in stromal cells of the human prostate in vitro.	gamma-sitosterol	47-62	protein kinase C alpha	Homo sapiens	148-157
9132417-8	1996	Preincubation of water-soluble pea porin with the plant sterol beta-sitosterol resulted in a considerable higher channel-forming activity than with all the other sterols used for preincubation.	gamma-sitosterol	63-78	outer plastidial membrane protein porin	Zea mays	35-40
8020891-0	1994	The effect of increased hepatic sitosterol on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol 7 alpha-hydroxylase in the rat and sitosterolemic homozygotes.	gamma-sitosterol	32-42	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	64-111
8020891-0	1994	The effect of increased hepatic sitosterol on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol 7 alpha-hydroxylase in the rat and sitosterolemic homozygotes.	gamma-sitosterol	32-42	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	116-147
8020891-6	1994	However, hepatic cholesterol 7 alpha-hydroxylase activity was inhibited 30% in both the sitosterolemic homozygotes and rats with high liver sitosterol concentrations.	gamma-sitosterol	88-98	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	17-48
8020891-9	1994	Thus the deficiency of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of sitosterolemic homozygotes is inherited and not due to the hepatic accumulation of sitosterol.	gamma-sitosterol	87-97	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	23-70
1767244-7	1991	However, we could not confirm previous reports that tissue plasminogen activator production was enhanced by sitosterol.	gamma-sitosterol	108-118	chromosome 20 open reading frame 181	Homo sapiens	52-80
8028508-0	1994	Deficient ileal 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in sitosterolemia: sitosterol is not a feedback inhibitor of intestinal cholesterol biosynthesis.	gamma-sitosterol	76-86	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	16-63
1601392-3	1992	Fasting serum insulin levels were inversely correlated with plasma plant sterol concentrations in diabetic patients (campesterol: r = -0.347, P = 0.012; betasitosterol: r = -0.345, P = 0.012) and in non-diabetic men (campesterol: r = -0.578, P = 0.039; betasitosterol: r = -0.702, P = 0.008).	gamma-sitosterol	153-167	insulin	Homo sapiens	14-21
1601392-3	1992	Fasting serum insulin levels were inversely correlated with plasma plant sterol concentrations in diabetic patients (campesterol: r = -0.347, P = 0.012; betasitosterol: r = -0.345, P = 0.012) and in non-diabetic men (campesterol: r = -0.578, P = 0.039; betasitosterol: r = -0.702, P = 0.008).	gamma-sitosterol	253-267	insulin	Homo sapiens	14-21
1501493-2	1992	beta-Sitosterol (SITO), estradiol (E2) and combined treatment (SITO + E2) induced significant increases in glycogen concentration and the activities of glucose-6-phosphate dehydrogenase (G6PDH), phosphohexose isomerase (PHI) and total lactate dehydrogenase (LDH).	gamma-sitosterol	0-15	glucose-6-phosphate dehydrogenase	Rattus norvegicus	152-185
1501493-2	1992	beta-Sitosterol (SITO), estradiol (E2) and combined treatment (SITO + E2) induced significant increases in glycogen concentration and the activities of glucose-6-phosphate dehydrogenase (G6PDH), phosphohexose isomerase (PHI) and total lactate dehydrogenase (LDH).	gamma-sitosterol	0-15	glucose-6-phosphate dehydrogenase	Rattus norvegicus	187-192
1501493-2	1992	beta-Sitosterol (SITO), estradiol (E2) and combined treatment (SITO + E2) induced significant increases in glycogen concentration and the activities of glucose-6-phosphate dehydrogenase (G6PDH), phosphohexose isomerase (PHI) and total lactate dehydrogenase (LDH).	gamma-sitosterol	0-15	glucose-6-phosphate isomerase	Rattus norvegicus	195-218
1501493-2	1992	beta-Sitosterol (SITO), estradiol (E2) and combined treatment (SITO + E2) induced significant increases in glycogen concentration and the activities of glucose-6-phosphate dehydrogenase (G6PDH), phosphohexose isomerase (PHI) and total lactate dehydrogenase (LDH).	gamma-sitosterol	0-15	glucose-6-phosphate isomerase	Rattus norvegicus	220-223
1501493-4	1992	Co-administration of P with beta-sitosterol (P + SITO) suppressed the SITO-induced increase in glycogen concentration and G6PDH activity.	gamma-sitosterol	28-43	glucose-6-phosphate dehydrogenase	Rattus norvegicus	122-127
1911714-5	1991	The average half-life of the first exponential (tA1/2) for sitosterol was 9.2 +/- 3.3 (mean +/- SD) days, which was more than twice that in normal humans.	gamma-sitosterol	59-69	trace amine associated receptor 1	Homo sapiens	48-53
2171663-1	1990	The rate of non-specific lipid transfer protein (nsLTP)-mediated exchange is independent of structure for dissimilar sterols: cholesterol, lanosterol, sitosterol and vitamin D-3.	gamma-sitosterol	151-161	sterol carrier protein 2	Homo sapiens	12-47
1898988-5	1991	Similarly, sitosterol and lupane-type triterpene derivatives markedly inhibited this TPA-induced ODC accumulation.	gamma-sitosterol	11-21	ornithine decarboxylase, structural 1	Mus musculus	97-100
2171663-1	1990	The rate of non-specific lipid transfer protein (nsLTP)-mediated exchange is independent of structure for dissimilar sterols: cholesterol, lanosterol, sitosterol and vitamin D-3.	gamma-sitosterol	151-161	sterol carrier protein 2	Homo sapiens	49-54
16531502-6	2006	Arabidopsis CYP710A2 was able to produce brassicasterol and stigmasterol from 24-epi-campesterol and beta-sitosterol, respectively.	gamma-sitosterol	101-116	cytochrome P450, family 710, subfamily A, polypeptide 2	Arabidopsis thaliana	12-20
33235245-0	2020	Bioassay-based Corchorus capsularis L. leaf-derived beta-sitosterol exerts antileishmanial effects against Leishmania donovani by targeting trypanothione reductase.	gamma-sitosterol	52-67	trypanothione reductase	Leishmania donovani	140-163
16531502-4	2006	The Arabidopsis CYP710A1 and tomato CYP710A11 proteins exhibited C-22 desaturase activity with beta-sitosterol to produce stigmasterol (CYP710A1, K(m) = 1.0 microM and kinetic constant [k(cat)] = 0.53 min(-1); CYP710A11, K(m) = 3.7 microM and k(cat) = 10 min(-1)).	gamma-sitosterol	95-110	cytochrome P450, family 710, subfamily A, polypeptide 1	Arabidopsis thaliana	16-24
34827970-0	2021	Beta-Sitosterol Promotes Milk Protein and Fat Syntheses-Related Genes in Bovine Mammary Epithelial Cells.	gamma-sitosterol	0-15	casein beta	Bos taurus	25-37
16531502-4	2006	The Arabidopsis CYP710A1 and tomato CYP710A11 proteins exhibited C-22 desaturase activity with beta-sitosterol to produce stigmasterol (CYP710A1, K(m) = 1.0 microM and kinetic constant [k(cat)] = 0.53 min(-1); CYP710A11, K(m) = 3.7 microM and k(cat) = 10 min(-1)).	gamma-sitosterol	95-110	cytochrome P450 710A11	Solanum lycopersicum	36-45
16531502-4	2006	The Arabidopsis CYP710A1 and tomato CYP710A11 proteins exhibited C-22 desaturase activity with beta-sitosterol to produce stigmasterol (CYP710A1, K(m) = 1.0 microM and kinetic constant [k(cat)] = 0.53 min(-1); CYP710A11, K(m) = 3.7 microM and k(cat) = 10 min(-1)).	gamma-sitosterol	95-110	cytochrome P450, family 710, subfamily A, polypeptide 1	Arabidopsis thaliana	36-44
16531502-4	2006	The Arabidopsis CYP710A1 and tomato CYP710A11 proteins exhibited C-22 desaturase activity with beta-sitosterol to produce stigmasterol (CYP710A1, K(m) = 1.0 microM and kinetic constant [k(cat)] = 0.53 min(-1); CYP710A11, K(m) = 3.7 microM and k(cat) = 10 min(-1)).	gamma-sitosterol	95-110	cytochrome P450 710A11	Solanum lycopersicum	210-219
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	gamma-sitosterol	192-207	cyclin dependent kinase inhibitor 1A	Homo sapiens	233-239
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	gamma-sitosterol	192-207	BCL2 apoptosis regulator	Homo sapiens	241-245
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	gamma-sitosterol	192-207	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	260-263
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	gamma-sitosterol	192-207	cyclin dependent kinase 2	Homo sapiens	265-269
34942456-12	2022	CONCLUSIONS: In summary, combined network pharmacology and biological experiments proved that the main ingredients of ZJC such as quercetin, (R)-Canadine, palmatine, rutaecarpine, evodiamine, beta-sitosterol and berberine can target CDKN1A, Bcl2, E2F1, PRKCB, MYC, CDK2 and MMP9 to combat colorectal cancer.	gamma-sitosterol	192-207	matrix metallopeptidase 9	Homo sapiens	274-278
34534598-15	2022	CONCLUSION: Synergistic action of genistin, quercetin-3-D-galactoside, 9,12,15-octadecatrienoic-acid methyl-ester, phytol, retinal, stigmasterol, n-hexadecanoic acid, beta-sitosterol in GRHA restores memory-deficits via attenuation of cholinesterase, beta-secretase, MAPt level and inhibition of oxidative-stress imparts inflammation in AD.	gamma-sitosterol	167-182	butyrylcholinesterase	Rattus norvegicus	235-249
34821900-5	2021	Western blot experiment results also showed that appropriate concentrations of LPSs and beta-sitosterol could up-regulate the expression of the anti-apoptotic protein Bcl-2 and down-regulate the pro-apoptotic proteins Bax and caspase-3 in GES-1 cells.	gamma-sitosterol	88-103	BCL2 apoptosis regulator	Homo sapiens	167-172
34821900-5	2021	Western blot experiment results also showed that appropriate concentrations of LPSs and beta-sitosterol could up-regulate the expression of the anti-apoptotic protein Bcl-2 and down-regulate the pro-apoptotic proteins Bax and caspase-3 in GES-1 cells.	gamma-sitosterol	88-103	BCL2 associated X, apoptosis regulator	Homo sapiens	218-221
34821900-5	2021	Western blot experiment results also showed that appropriate concentrations of LPSs and beta-sitosterol could up-regulate the expression of the anti-apoptotic protein Bcl-2 and down-regulate the pro-apoptotic proteins Bax and caspase-3 in GES-1 cells.	gamma-sitosterol	88-103	caspase 3	Homo sapiens	226-235
34763044-15	2022	Molecular docking analysis revealed strong molecular interactions of pyrogallol and sitosterol with GLUT4.	gamma-sitosterol	84-94	solute carrier family 2 member 4	Rattus norvegicus	100-105
34931591-7	2022	An in-depth study of the mechanism of QFPD in the treatment of pulmonary fibrosis based on network pharmacology and molecular simulation revealed that SRC was the main target of QFPD and sitosterol (a key compound in QFPD).	gamma-sitosterol	187-197	Rous sarcoma oncogene	Mus musculus	151-154
34931591-8	2022	QFPD and sitosterol regulate the EMT process and M2 polarization of macrophages by inhibiting the activation of SRC, thereby alleviating pulmonary fibrosis in mice.	gamma-sitosterol	9-19	Rous sarcoma oncogene	Mus musculus	112-115
34827970-0	2021	Beta-Sitosterol Promotes Milk Protein and Fat Syntheses-Related Genes in Bovine Mammary Epithelial Cells.	gamma-sitosterol	0-15	FAT atypical cadherin 1	Bos taurus	42-45
34766880-6	2021	The main protease (Mpro) of SARS-CoV-2 interacted closely with jatamansin (JM), 6,7-dehydroferruginol (FG) and beta-sitosterol (BS), while Papain-like Protease (PLpro) with friedelane-3-one (F3O) and lantadene D (LD) independently.	gamma-sitosterol	111-126	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	19-23
34827970-3	2021	This study aimed to investigate the effects of beta-sitosterol on milk fat and protein syntheses in bovine mammary epithelial cells (MAC-T) and its regulatory mechanism.	gamma-sitosterol	47-62	FAT atypical cadherin 1	Bos taurus	71-74
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	signal transducer and activator of transcription 5A	Homo sapiens	133-138
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	mechanistic target of rapamycin kinase	Homo sapiens	141-170
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	mechanistic target of rapamycin kinase	Homo sapiens	172-176
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	ribosomal protein S6 kinase A1	Homo sapiens	183-217
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	ribosomal protein S6 kinase B1	Homo sapiens	219-223
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	Janus kinase 2	Homo sapiens	232-236
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	signal transducer and activator of transcription 5A	Homo sapiens	237-242
34827970-6	2021	beta-sitosterol (0.1, 1, 10 muM) increased the mRNA and protein expression levels of signal transducer activator of transcription 5 (STAT5), mammalian target of rapamycin (mTOR), and ribosomal protein S6 kinase beta-1 (S6K1) of the JAK2/STAT5 and mTOR signaling pathways.	gamma-sitosterol	0-15	mechanistic target of rapamycin kinase	Homo sapiens	247-251
34827970-8	2021	beta-sitosterol (0.1, 1, 10 muM) also significantly increased the expression of growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and hypoxia-inducible factor-1alpha (HIF-1alpha)-related genes.	gamma-sitosterol	0-15	gamma-glutamyl hydrolase	Bos taurus	125-127
34827970-8	2021	beta-sitosterol (0.1, 1, 10 muM) also significantly increased the expression of growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and hypoxia-inducible factor-1alpha (HIF-1alpha)-related genes.	gamma-sitosterol	0-15	insulin like growth factor 1	Bos taurus	128-133
34827970-8	2021	beta-sitosterol (0.1, 1, 10 muM) also significantly increased the expression of growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and hypoxia-inducible factor-1alpha (HIF-1alpha)-related genes.	gamma-sitosterol	0-15	hypoxia inducible factor 1 subunit alpha	Bos taurus	144-175
34827970-8	2021	beta-sitosterol (0.1, 1, 10 muM) also significantly increased the expression of growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and hypoxia-inducible factor-1alpha (HIF-1alpha)-related genes.	gamma-sitosterol	0-15	hypoxia inducible factor 1 subunit alpha	Bos taurus	177-187
34827970-10	2021	These results highlight the role of beta-sitosterol at concentrations ranging from 0.1 to 10 muM in improving milk protein and fat syntheses, regulating milk quality.	gamma-sitosterol	36-51	casein beta	Bos taurus	110-122
34827970-10	2021	These results highlight the role of beta-sitosterol at concentrations ranging from 0.1 to 10 muM in improving milk protein and fat syntheses, regulating milk quality.	gamma-sitosterol	36-51	FAT atypical cadherin 1	Bos taurus	127-130
34727589-8	2021	Molecular docking revealed that gamma-sitosterol, alpha-amyrin, and stigmasterol have outstanding binding affinity for M3 and EP3.	gamma-sitosterol	32-48	prostaglandin E receptor 3 (subtype EP3)	Mus musculus	126-129
34680591-3	2021	ABCG5 (rs4245786) and the tag SNP ABCG8 (rs4245791) were significantly associated with serum campesterol and/or sitosterol levels.	gamma-sitosterol	112-122	ATP binding cassette subfamily G member 5	Homo sapiens	0-5
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	gamma-sitosterol	142-157	interleukin 6	Homo sapiens	219-222
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	gamma-sitosterol	142-157	prostaglandin-endoperoxide synthase 2	Homo sapiens	224-229
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	gamma-sitosterol	142-157	mitogen-activated protein kinase 3	Homo sapiens	238-243
34754315-10	2021	Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1.	gamma-sitosterol	142-157	calcitonin related polypeptide alpha	Homo sapiens	249-254
34746302-16	2021	The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD.	gamma-sitosterol	77-92	AKT serine/threonine kinase 1	Homo sapiens	143-147
34746302-16	2021	The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD.	gamma-sitosterol	77-92	vascular endothelial growth factor A	Homo sapiens	149-154
34746302-16	2021	The hub components possibly include quercetin, stigmasterol, kaempferol, and beta-sitosterol and act through pairing with hub targets, such as AKT1, VEGFA, and IL6, to regulate neuronal death, G protein-coupled amine receptor activity, reactive oxygen species metabolic process, membrane raft, MAPK signaling pathway, and cellular senescence for the treatment of PD.	gamma-sitosterol	77-92	interleukin 6	Homo sapiens	160-163
34733451-11	2021	Molecular docking showed that the active components of XJD (beta-sitosterol, kaempferol, formononetin, quercetin, and luteolin) showed good binding activities to five of the six hub gene targets.	gamma-sitosterol	60-75	ELAV like RNA binding protein 2	Homo sapiens	178-181
34733451-13	2021	The active ingredients of XJD (beta-sitosterol, kaempferol, formononetin, quercetin, and luteolin) may regulate the inflammatory and oxidative stress-related pathways of colon cells during the course of UC by binding to the hub gene targets.	gamma-sitosterol	31-46	ELAV like RNA binding protein 2	Homo sapiens	224-227
34680591-3	2021	ABCG5 (rs4245786) and the tag SNP ABCG8 (rs4245791) were significantly associated with serum campesterol and/or sitosterol levels.	gamma-sitosterol	112-122	ATP binding cassette subfamily G member 8	Homo sapiens	34-39
34679718-0	2021	ER-Mitochondria Calcium Flux by beta-Sitosterol Promotes Cell Death in Ovarian Cancer.	gamma-sitosterol	32-47	epiregulin	Homo sapiens	0-2
34649566-6	2021	RESULTS: According to topological analysis results, AKT1, MAPK1, ESR1, and SRC are critical genes for RRP to treat osteoporosis, and they have high binding activity with stigmasterol and sitosterol.	gamma-sitosterol	187-197	AKT serine/threonine kinase 1	Homo sapiens	52-56
34649566-6	2021	RESULTS: According to topological analysis results, AKT1, MAPK1, ESR1, and SRC are critical genes for RRP to treat osteoporosis, and they have high binding activity with stigmasterol and sitosterol.	gamma-sitosterol	187-197	mitogen-activated protein kinase 1	Homo sapiens	58-63
34649566-6	2021	RESULTS: According to topological analysis results, AKT1, MAPK1, ESR1, and SRC are critical genes for RRP to treat osteoporosis, and they have high binding activity with stigmasterol and sitosterol.	gamma-sitosterol	187-197	estrogen receptor 1	Homo sapiens	65-69
34649566-6	2021	RESULTS: According to topological analysis results, AKT1, MAPK1, ESR1, and SRC are critical genes for RRP to treat osteoporosis, and they have high binding activity with stigmasterol and sitosterol.	gamma-sitosterol	187-197	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-78
34615826-3	2022	However, a genetic analysis revealed a compound heterozygous mutation in the ABCG5 gene with a high serum level of sitosterol, leading to the diagnosis of sitosterolemia.	gamma-sitosterol	115-125	ATP binding cassette subfamily G member 5	Homo sapiens	77-82
34641514-3	2021	The alpha-glucosidase inhibitory assay screening resulted in the isolation of eight known compounds of quercetin, quercitrin, luteolin, 5-deoxyluteolin, 4-methyl ether isoliquiritigenin, 3,2",4"-trihydroxy-4-methoxychalcone, stigmasterol and beta-sitosterol.	gamma-sitosterol	242-257	sucrase-isomaltase	Homo sapiens	4-21
34675500-0	2021	MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in gamma-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease.	gamma-sitosterol	58-74	microRNA 361	Homo sapiens	0-7
34675500-0	2021	MiR-361-5p/abca1 and MiR-196-5p/arhgef12 Axis Involved in gamma-Sitosterol Inducing Dual Anti-Proliferative Effects on Bronchial Epithelial Cells of Chronic Obstructive Pulmonary Disease.	gamma-sitosterol	58-74	Rho guanine nucleotide exchange factor 12	Homo sapiens	32-40
34675500-5	2021	Next, the effects of gamma-sitosterol (GS) on the expression of miR-361-5p and miR-196-5p and cell proliferation were investigated in BEC and H292 cell lines.	gamma-sitosterol	21-37	microRNA 361	Homo sapiens	64-71
34291081-8	2021	Amongst, the binding affinity for beta-sitosterol and beta-elemene against S-ACE2 showed -12.0 and -10.9 kcal/mol, respectively.	gamma-sitosterol	34-49	angiotensin converting enzyme 2	Homo sapiens	77-81
34257681-8	2021	The molecular docking results showed that the binding energies of beta sitosterol with AR, FOS, AKT1, VEGFA, NR3C1, and NOS3 were less than -7.0 kcal mol-1, indicating a good docking effect.	gamma-sitosterol	66-81	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	91-94
34257681-8	2021	The molecular docking results showed that the binding energies of beta sitosterol with AR, FOS, AKT1, VEGFA, NR3C1, and NOS3 were less than -7.0 kcal mol-1, indicating a good docking effect.	gamma-sitosterol	66-81	AKT serine/threonine kinase 1	Homo sapiens	96-100
34257681-8	2021	The molecular docking results showed that the binding energies of beta sitosterol with AR, FOS, AKT1, VEGFA, NR3C1, and NOS3 were less than -7.0 kcal mol-1, indicating a good docking effect.	gamma-sitosterol	66-81	vascular endothelial growth factor A	Homo sapiens	102-107
34257681-8	2021	The molecular docking results showed that the binding energies of beta sitosterol with AR, FOS, AKT1, VEGFA, NR3C1, and NOS3 were less than -7.0 kcal mol-1, indicating a good docking effect.	gamma-sitosterol	66-81	nuclear receptor subfamily 3 group C member 1	Homo sapiens	109-114
34257681-8	2021	The molecular docking results showed that the binding energies of beta sitosterol with AR, FOS, AKT1, VEGFA, NR3C1, and NOS3 were less than -7.0 kcal mol-1, indicating a good docking effect.	gamma-sitosterol	66-81	nitric oxide synthase 3	Homo sapiens	120-124
34094906-11	2021	This study showed that SAE, by containing beta-sitosterol with proven anticancer effects, induces anoikis through the EGFR/Akt pathway in HCT116 colorectal cancer cells both in vitro and in vivo.	gamma-sitosterol	42-57	epidermal growth factor receptor	Homo sapiens	118-122
34211564-11	2021	Molecular docking indicated that kaempferol, sesamin, and beta-sitosterol were closely related to PTGS2 and PPARG and were superior to aminophylline.	gamma-sitosterol	58-73	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	98-103
34211564-11	2021	Molecular docking indicated that kaempferol, sesamin, and beta-sitosterol were closely related to PTGS2 and PPARG and were superior to aminophylline.	gamma-sitosterol	58-73	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	108-113
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-171
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	caspase 3	Homo sapiens	173-178
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	tumor protein p53	Homo sapiens	180-184
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	interleukin 6	Homo sapiens	186-190
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	tumor necrosis factor	Homo sapiens	192-195
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	AKT serine/threonine kinase 1	Homo sapiens	201-205
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	AKT serine/threonine kinase 1	Homo sapiens	287-290
34149863-13	2021	SCDP key active ingredients are mainly quercetin, wogonin, baicalein, acacetin, oroxylin A, and beta-sitosterol, which function mainly by regulating targets, such as PTGS2, CASP3, TP53, IL-6, TNF, and AKT1, and are associated with multiple signaling pathways as pathways in cancer, PI3K-Akt signaling pathway, apoptosis, IL-17 signaling pathways.	gamma-sitosterol	96-111	interleukin 17A	Homo sapiens	321-326
34179058-12	2021	Results: With the treatment of beta-sitosterol and beta-sitosterol-FMT, the uterine index of PCOS-like mice increased, the ovarian index decreased, levels of COX-2, LH and T decreased, and levels of Integrin alphanubeta3, LIF, HOXA10, FSH, and P increased.	gamma-sitosterol	31-46	prostaglandin-endoperoxide synthase 2	Mus musculus	158-163
34179058-12	2021	Results: With the treatment of beta-sitosterol and beta-sitosterol-FMT, the uterine index of PCOS-like mice increased, the ovarian index decreased, levels of COX-2, LH and T decreased, and levels of Integrin alphanubeta3, LIF, HOXA10, FSH, and P increased.	gamma-sitosterol	31-46	leukemia inhibitory factor	Mus musculus	222-225
34179058-12	2021	Results: With the treatment of beta-sitosterol and beta-sitosterol-FMT, the uterine index of PCOS-like mice increased, the ovarian index decreased, levels of COX-2, LH and T decreased, and levels of Integrin alphanubeta3, LIF, HOXA10, FSH, and P increased.	gamma-sitosterol	31-46	homeobox A10	Mus musculus	227-233
34179058-12	2021	Results: With the treatment of beta-sitosterol and beta-sitosterol-FMT, the uterine index of PCOS-like mice increased, the ovarian index decreased, levels of COX-2, LH and T decreased, and levels of Integrin alphanubeta3, LIF, HOXA10, FSH, and P increased.	gamma-sitosterol	31-46	follicle stimulating hormone beta	Mus musculus	235-238
34094906-11	2021	This study showed that SAE, by containing beta-sitosterol with proven anticancer effects, induces anoikis through the EGFR/Akt pathway in HCT116 colorectal cancer cells both in vitro and in vivo.	gamma-sitosterol	42-57	AKT serine/threonine kinase 1	Homo sapiens	123-126
35493299-7	2022	The desmosterol, lathosterol, campesterol, stigmasterol, and sitosterol were statistically different in the FHC group than the hyperlipidemic group (P < 0.05).	gamma-sitosterol	61-71	low density lipoprotein receptor	Homo sapiens	108-111
34095883-6	2021	beta-sitosterol injection reduces the effects of restraint stress, contextual fear memory, and c-Fos activation in the prefrontal cortex and dentate gyrus.	gamma-sitosterol	0-15	FBJ osteosarcoma oncogene	Mus musculus	95-100
35487926-5	2022	Additionally, inhibition of IL-1beta secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and beta-sitosterol.	gamma-sitosterol	128-143	interleukin 1 alpha	Mus musculus	28-36
35487926-5	2022	Additionally, inhibition of IL-1beta secretion and TRAP activity were determined for chlorogenic acid, catechin, naringenin and beta-sitosterol.	gamma-sitosterol	128-143	acid phosphatase 5, tartrate resistant	Mus musculus	51-55
35487926-10	2022	IL-6 secretion was significantly inhibited by P. africana methanolic extract (p < 0.0001) and beta-sitosterol (p < 0.0001) and further, chlorogenic acid and naringenin remarkably inhibited IL-1beta production.	gamma-sitosterol	94-109	interleukin 1 alpha	Mus musculus	189-197
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	gamma-sitosterol	122-137	prostaglandin-endoperoxide synthase 2	Homo sapiens	174-179
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	gamma-sitosterol	122-137	caspase 3	Homo sapiens	181-186
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	gamma-sitosterol	122-137	mitogen-activated protein kinase 1	Homo sapiens	188-193
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	gamma-sitosterol	122-137	mitogen-activated protein kinase 3	Homo sapiens	195-200
35510223-13	2022	The molecular docking results showed that there was a certain affinity between the main compounds (kaempferol, quercetin, beta-sitosterol, naringenin) and core target genes (PTGS2, CASP3, MAPK1, MAPK3, TP53).	gamma-sitosterol	122-137	tumor protein p53	Homo sapiens	202-206
35571728-7	2022	Molecular docking results revealed that beta-carotene and sitosterol were acting as interference factors in attenuating inflammation by binding to an accessory protein of ERK, JNK, AKT, and NF-kappaB p65.	gamma-sitosterol	58-68	mitogen-activated protein kinase 1	Mus musculus	171-174
35571728-7	2022	Molecular docking results revealed that beta-carotene and sitosterol were acting as interference factors in attenuating inflammation by binding to an accessory protein of ERK, JNK, AKT, and NF-kappaB p65.	gamma-sitosterol	58-68	mitogen-activated protein kinase 8	Mus musculus	176-179
35571728-7	2022	Molecular docking results revealed that beta-carotene and sitosterol were acting as interference factors in attenuating inflammation by binding to an accessory protein of ERK, JNK, AKT, and NF-kappaB p65.	gamma-sitosterol	58-68	thymoma viral proto-oncogene 1	Mus musculus	181-184
35571728-7	2022	Molecular docking results revealed that beta-carotene and sitosterol were acting as interference factors in attenuating inflammation by binding to an accessory protein of ERK, JNK, AKT, and NF-kappaB p65.	gamma-sitosterol	58-68	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	200-203
35493299-8	2022	The proportions of squalene/cholesterol, lathosterol/cholesterol, stigmasterol/cholesterol, and sitosterol/cholesterol in the FHC group were lower than those in the hyperlipidemic group; only desmosterol/cholesterol was higher than that in the hyperlipidemic group.	gamma-sitosterol	96-106	low density lipoprotein receptor	Homo sapiens	126-129
35433930-15	2022	Acacetin, wogonin, baicalein, oroxylin A, and beta-sitosterol, which are rich in RS, are closely related to hemagglutinin (HA), NeurAminidase (NA), nucleoprotein (NP), polymerase basic protein 1 (PB1), polymerase basic protein 2 (PB2), polymerase acidic (PA), matrix protein 1 (M1), matrix protein 2 (M2), and non-structural protein (NS), which are the main RNA coding proteins of influenza A virus.	gamma-sitosterol	50-61	neuraminidase 1	Homo sapiens	128-141
35388303-9	2022	The key active ingredients were mainly quercetin, beta-estradiol, berberine, wogonin, and beta-sitosterol, and the key targets were also identified, including IL-6, AKT1, MAPK3, PIK3CA, and TNF.	gamma-sitosterol	90-105	interleukin 6	Homo sapiens	159-163
35388303-9	2022	The key active ingredients were mainly quercetin, beta-estradiol, berberine, wogonin, and beta-sitosterol, and the key targets were also identified, including IL-6, AKT1, MAPK3, PIK3CA, and TNF.	gamma-sitosterol	90-105	mitogen-activated protein kinase 3	Homo sapiens	171-176
35388303-9	2022	The key active ingredients were mainly quercetin, beta-estradiol, berberine, wogonin, and beta-sitosterol, and the key targets were also identified, including IL-6, AKT1, MAPK3, PIK3CA, and TNF.	gamma-sitosterol	90-105	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	178-184
35388303-9	2022	The key active ingredients were mainly quercetin, beta-estradiol, berberine, wogonin, and beta-sitosterol, and the key targets were also identified, including IL-6, AKT1, MAPK3, PIK3CA, and TNF.	gamma-sitosterol	90-105	tumor necrosis factor	Homo sapiens	190-193
35433930-15	2022	Acacetin, wogonin, baicalein, oroxylin A, and beta-sitosterol, which are rich in RS, are closely related to hemagglutinin (HA), NeurAminidase (NA), nucleoprotein (NP), polymerase basic protein 1 (PB1), polymerase basic protein 2 (PB2), polymerase acidic (PA), matrix protein 1 (M1), matrix protein 2 (M2), and non-structural protein (NS), which are the main RNA coding proteins of influenza A virus.	gamma-sitosterol	50-61	polybromo 1	Homo sapiens	196-199
35311172-7	2022	Gas chromatography mass spectrometry (GC-MS) analysis of HE identified several anticancer compounds including palmitic acid, linoleic acid, oleic acid, campesterol, stigmasterol, and gamma-sitosterol, supporting the anticancer potential of HE.	gamma-sitosterol	183-199	gastrin	Homo sapiens	0-3
35295740-0	2021	beta-Sitosterol Inhibits Rheumatoid Synovial Angiogenesis Through Suppressing VEGF Signaling Pathway.	gamma-sitosterol	0-15	vascular endothelial growth factor A	Mus musculus	78-82
35237152-9	2022	This demonstrated that quercetin, luteolin, hyndarin, and beta-sitosterol had good binding to eight key proteins, and Akt1 was the target protein with the best binding activity, suggesting that Akt1 could be the essential mediator responsible for signaling transduction after QZZTD administration.	gamma-sitosterol	58-73	AKT serine/threonine kinase 1	Rattus norvegicus	118-122
35237152-9	2022	This demonstrated that quercetin, luteolin, hyndarin, and beta-sitosterol had good binding to eight key proteins, and Akt1 was the target protein with the best binding activity, suggesting that Akt1 could be the essential mediator responsible for signaling transduction after QZZTD administration.	gamma-sitosterol	58-73	AKT serine/threonine kinase 1	Rattus norvegicus	194-198
2747437-4	1989	The hepatic HMG-CoA reductase activity was unaffected or slightly increased by the sitosterol infusions (not statistically significant).	gamma-sitosterol	83-93	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	12-29
2747437-12	1989	The possibility is discussed that the hypercholesterolemia obtained in the beta-sitosterol-infused rats is due to the inhibitory effect of sitosterol on the cholesterol 7 alpha-hydroxylase.	gamma-sitosterol	75-90	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	157-188
2747437-12	1989	The possibility is discussed that the hypercholesterolemia obtained in the beta-sitosterol-infused rats is due to the inhibitory effect of sitosterol on the cholesterol 7 alpha-hydroxylase.	gamma-sitosterol	80-90	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	157-188
3143743-5	1988	Cholestanol and sitosterol competitively inhibited cholesterol 7 alpha-hydroxylase in both rat and human liver microsomes, with cholestanol the more potent inhibitor.	gamma-sitosterol	16-26	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	51-82
3143743-6	1988	Patients with sitosterolemia with xanthomatosis, who have elevated microsomal cholestanol and sitosterol, showed reduced cholesterol 7 alpha-hydroxylase activity relative to the activity in control subjects (13.9 and 14.7 vs. 20.3 +/- 0.9 pmol/nmol P-450 per min, P less than 0.01).	gamma-sitosterol	14-24	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	121-152
3143743-8	1988	Ileal bypass surgery in one sitosterolemic patient decreased plasma cholestanol and sitosterol concentrations and resulted in a 30% increase in hepatic microsomal cholesterol 7 alpha-hydroxylase activity.	gamma-sitosterol	28-38	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	163-194
3143743-9	1988	Cholesterol 7 alpha-hydroxylase appears to have a specific apolar binding site for the side chain of cholesterol and is affected by the presence of cholestanol and sitosterol in the microsomal substrate pool.	gamma-sitosterol	164-174	cytochrome P450 family 7 subfamily A member 1	Homo sapiens	0-31
4729973-6	1973	Rats fed sitosterol plus taurocholate had nearly normal HMG CoA reductase activity, but cholesterol 7alpha-hydroxylase was inhibited and biliary cholesterol remained high.	gamma-sitosterol	9-19	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	88-118
6854150-0	1983	beta-sitosterol: esterification by intestinal acylcoenzyme A: cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification.	gamma-sitosterol	0-15	sterol O-acyltransferase 1	Oryctolagus cuniculus	91-95
6854150-16	1983	beta-Sitosterol: esterification by intestinal acylcoenzyme A:cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification.	gamma-sitosterol	0-15	liver carboxylesterase 1	Oryctolagus cuniculus	46-88
6854150-16	1983	beta-Sitosterol: esterification by intestinal acylcoenzyme A:cholesterol acyltransferase (ACAT) and its effect on cholesterol esterification.	gamma-sitosterol	0-15	sterol O-acyltransferase 1	Oryctolagus cuniculus	90-94
3473613-0	1986	Metabolism of 24-ethyl-4-cholesten-3-one and 24-ethyl-5-cholesten-3 beta-ol (sitosterol) after intraperitoneal injection in the rat.	gamma-sitosterol	77-87	integrin subunit beta 1	Rattus norvegicus	68-75
6715090-0	1984	Serum lipoproteins and lecithin: cholesterol acyltransferase (LCAT) activity in hypercholesterolemic subjects given beta-sitosterol.	gamma-sitosterol	116-131	lecithin-cholesterol acyltransferase	Homo sapiens	62-66
6715090-1	1984	We studied the effect on the serum LCAT activity and apolipoproteins in ten subjects with primary hypercholesterolemia after treatment with beta-sitosterol.	gamma-sitosterol	140-155	lecithin-cholesterol acyltransferase	Homo sapiens	35-39
6715090-2	1984	The 2-month administration of beta-sitosterol resulted in an increase of the fractional as well as of the molar esterification rate of the LCAT.	gamma-sitosterol	30-45	lecithin-cholesterol acyltransferase	Homo sapiens	139-143
6715090-4	1984	We conclude that beta-sitosterol primarily lowers cholesterol-rich lipoproteins with a lower density range than LDL via an accelerated esterification rate of the LCAT enzyme.	gamma-sitosterol	17-32	lecithin-cholesterol acyltransferase	Homo sapiens	162-166
7119904-7	1982	There was possibly a trend toward higher serum apoA-I with supplementation of beta-sitosterol in a butter-fat diet.	gamma-sitosterol	78-93	apolipoprotein A1	Rattus norvegicus	47-53
1137717-11	1975	In beta-sitosterol-fed animals, the reductase was increased 2-fold and cholesterol 7 alpha-hydroxylase was not significantly different from controls.	gamma-sitosterol	3-18	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	71-102
4729973-4	1973	Dietary sitosterol produced increases in the specific activity of HMG CoA reductase (3.6-fold) and cholesterol 7alpha-hydroxylase (1.4-fold), and biliary cholesterol concentrations in this group more than doubled.	gamma-sitosterol	8-18	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	99-129
33997001-9	2021	betaS-treated rats had remarkably lower levels of IL-1beta, IL-6, IL-10, TNF-alpha, NF-kappaBi, AST, and ALT (51.79%, 62.63%, 41.46%, 54.35%, 94.37%, 95.30%, 34.87%, and 46.53% lower, respectively) and greater liver GSH content (35.71% greater) compared to the CLP group (p < 0.05).	gamma-sitosterol	0-5	interleukin 1 alpha	Rattus norvegicus	50-58
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	gamma-sitosterol	93-108	vascular endothelial growth factor A	Homo sapiens	142-147
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	gamma-sitosterol	93-108	interleukin 6	Homo sapiens	149-152
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	gamma-sitosterol	93-108	tumor necrosis factor	Homo sapiens	154-157
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	gamma-sitosterol	93-108	AKT serine/threonine kinase 1	Homo sapiens	159-163
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	gamma-sitosterol	93-108	tumor protein p53	Homo sapiens	169-173
5123890-6	1971	Addition of herring oil, linoleic acid or 0.1% oxidized sitosterol to the diets allows induction of cytochrome P-450 to take place.	gamma-sitosterol	56-66	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	100-116
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	vascular endothelial growth factor A	Homo sapiens	152-157
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	interleukin 6	Homo sapiens	159-162
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	tumor necrosis factor	Homo sapiens	164-167
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	AKT serine/threonine kinase 1	Homo sapiens	169-173
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	tumor protein p53	Homo sapiens	179-183
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	gamma-sitosterol	104-119	tumor necrosis factor	Homo sapiens	204-207
33997001-9	2021	betaS-treated rats had remarkably lower levels of IL-1beta, IL-6, IL-10, TNF-alpha, NF-kappaBi, AST, and ALT (51.79%, 62.63%, 41.46%, 54.35%, 94.37%, 95.30%, 34.87%, and 46.53% lower, respectively) and greater liver GSH content (35.71% greater) compared to the CLP group (p < 0.05).	gamma-sitosterol	0-5	interleukin 6	Rattus norvegicus	60-64
33997001-9	2021	betaS-treated rats had remarkably lower levels of IL-1beta, IL-6, IL-10, TNF-alpha, NF-kappaBi, AST, and ALT (51.79%, 62.63%, 41.46%, 54.35%, 94.37%, 95.30%, 34.87%, and 46.53% lower, respectively) and greater liver GSH content (35.71% greater) compared to the CLP group (p < 0.05).	gamma-sitosterol	0-5	interleukin 10	Rattus norvegicus	66-71
33997001-9	2021	betaS-treated rats had remarkably lower levels of IL-1beta, IL-6, IL-10, TNF-alpha, NF-kappaBi, AST, and ALT (51.79%, 62.63%, 41.46%, 54.35%, 94.37%, 95.30%, 34.87%, and 46.53% lower, respectively) and greater liver GSH content (35.71% greater) compared to the CLP group (p < 0.05).	gamma-sitosterol	0-5	tumor necrosis factor	Rattus norvegicus	73-82
33917607-0	2021	beta-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKbeta/NF-kappaB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats.	gamma-sitosterol	0-15	component of inhibitor of nuclear factor kappa B kinase complex	Rattus norvegicus	99-106
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	gamma-sitosterol	80-95	Janus kinase 2	Homo sapiens	203-208
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	gamma-sitosterol	80-95	signal transducer and activator of transcription 3	Homo sapiens	209-215
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	gamma-sitosterol	80-95	cyclin D1	Homo sapiens	263-272
33959188-7	2021	The results demonstrated that quercetin, ephedrine, trigonelline, crocetin, and beta-sitosterol were major effective compounds of LPD responsible for the CG treatment by inhibiting the activation of the JAK 2-STAT 3 signaling pathway to reduce the expressions of cyclin D1 and Bcl-2 proteins.	gamma-sitosterol	80-95	BCL2 apoptosis regulator	Homo sapiens	277-282
33963719-8	2021	Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol.	gamma-sitosterol	183-193	AKT serine/threonine kinase 1	Homo sapiens	30-34
33963719-8	2021	Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol.	gamma-sitosterol	183-193	interleukin 6	Homo sapiens	36-41
33963719-8	2021	Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol.	gamma-sitosterol	183-193	tumor necrosis factor	Homo sapiens	48-51
33963719-8	2021	Several key targets including AKT1, IL- 6, JUN, TNF and CASP3 were screened for molecular docking, which had good binding activities with berberrubine, epiberberine, stigmasterol and sitosterol.	gamma-sitosterol	183-193	caspase 3	Homo sapiens	56-61
33917607-0	2021	beta-Sitosterol Circumvents Obesity Induced Inflammation and Insulin Resistance by down-Regulating IKKbeta/NF-kappaB and JNK Signaling Pathway in Adipocytes of Type 2 Diabetic Rats.	gamma-sitosterol	0-15	mitogen-activated protein kinase 8	Rattus norvegicus	121-124
33684145-0	2021	beta-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model.	gamma-sitosterol	0-15	ceramide synthase 3	Homo sapiens	116-135
33684145-0	2021	beta-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model.	gamma-sitosterol	0-15	UDP-glucose ceramide glucosyltransferase	Homo sapiens	140-165
33849106-11	2021	The results of molecular docking further illustrated the roles that the compounds with quercetin and beta-sitosterol play in the treatment of CHD through their interference with AKT1 and MAPK1 target proteins.	gamma-sitosterol	101-116	AKT serine/threonine kinase 1	Homo sapiens	178-182
33849106-11	2021	The results of molecular docking further illustrated the roles that the compounds with quercetin and beta-sitosterol play in the treatment of CHD through their interference with AKT1 and MAPK1 target proteins.	gamma-sitosterol	101-116	mitogen-activated protein kinase 1	Homo sapiens	187-192
33669566-8	2021	Campesterol and beta-sitosterol concentrations were lower in patients with a severe CFTR genotype, pancreatic insufficiency and lower pancreatic enzyme dose (lipase units/gram of fat).	gamma-sitosterol	16-31	CF transmembrane conductance regulator	Homo sapiens	84-88
33557005-9	2021	Moneymaker for the sterol 22C-desaturase gene CYP710A11, responsible for the conversion of beta-sitosterol to stigmasterol.	gamma-sitosterol	91-106	cytochrome P450 710A11	Solanum lycopersicum	46-55
33171206-9	2021	The 24S-OHC levels, the 24S-OHC/27-OHC ratio and the plant sterols campesterol and sitosterol were associated with the tau and p-tau levels.	gamma-sitosterol	83-93	microtubule associated protein tau	Homo sapiens	119-122
33189282-4	2021	Of the phytosterols, beta-sitosterol was the main sterol of vegetal origin in donkey milk (0.005 +- 0.002 g/100 g of fat), but lower levels of campesterol, brassicasterol, and stigmasterol were also recorded.	gamma-sitosterol	21-36	FAT atypical cadherin 1	Homo sapiens	117-120
33398633-6	2021	Among them, beta-sitosterol was found with the highest binding affinity - 12.2 kcal/mol and stable interactions with the amino acid residues present on the active site of the ACE-2 receptor.	gamma-sitosterol	12-27	angiotensin converting enzyme 2	Homo sapiens	175-180
33406774-3	2021	Here, by using the sterol biosynthesis mutant cyclopropylsterol isomerase1-1 (cpi1-1) and sterol application, we reveal that cycloeucalenol, a CPI1 substrate, and sitosterol, an end-product of sterol biosynthesis, antagonistically affect auxin biosynthesis.	gamma-sitosterol	163-173	cyclopropyl isomerase	Arabidopsis thaliana	78-82
33171206-9	2021	The 24S-OHC levels, the 24S-OHC/27-OHC ratio and the plant sterols campesterol and sitosterol were associated with the tau and p-tau levels.	gamma-sitosterol	83-93	microtubule associated protein tau	Homo sapiens	129-132
33171206-12	2021	The plant sterols campesterol and sitosterol appear to be involved in tau pathology and neurodegeneration.	gamma-sitosterol	34-44	microtubule associated protein tau	Homo sapiens	70-73
32945205-0	2020	beta-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund"s adjuvant-induced arthritis in rats: involvement of NF-kB and HO-1/Nrf-2 pathway.	gamma-sitosterol	0-15	nuclear factor kappa B subunit 1	Rattus norvegicus	129-134
33254438-10	2020	The possible mechanism underlying the antidiabetic effects was revealed by molecular docking analyses examining the binding of beta-sitosterol and stigmasterol with sirtuin 4, an NAD-dependent deacylase enzyme that downregulates leucine-induced and glutamate dehydrogenase-induced insulin secretion.	gamma-sitosterol	127-142	sirtuin 4	Mus musculus	165-174
33254438-11	2020	The binding affinities between sirtuin 4 and beta-sitosterol, stigmasterol, and NAD were found to be -8.6 kcal/mol, -7.2 kcal/mol and -9.5 kcal/mol, respectively, indicating the probable competition between NAD and the isolated components for sirtuin 4.	gamma-sitosterol	45-60	sirtuin 4	Mus musculus	31-40
33254438-11	2020	The binding affinities between sirtuin 4 and beta-sitosterol, stigmasterol, and NAD were found to be -8.6 kcal/mol, -7.2 kcal/mol and -9.5 kcal/mol, respectively, indicating the probable competition between NAD and the isolated components for sirtuin 4.	gamma-sitosterol	45-60	sirtuin 4	Mus musculus	243-252
32945205-0	2020	beta-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund"s adjuvant-induced arthritis in rats: involvement of NF-kB and HO-1/Nrf-2 pathway.	gamma-sitosterol	0-15	heme oxygenase 1	Rattus norvegicus	139-143
32945205-0	2020	beta-Sitosterol-loaded solid lipid nanoparticles ameliorate complete Freund"s adjuvant-induced arthritis in rats: involvement of NF-kB and HO-1/Nrf-2 pathway.	gamma-sitosterol	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	144-149
32945205-9	2020	beta-sitosterol-SLN significantly (p < .001) reduced the level of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), vascular Endothelial Growth Factor (VEGF) and NF-kappaB.	gamma-sitosterol	0-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	66-82
32945205-9	2020	beta-sitosterol-SLN significantly (p < .001) reduced the level of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), vascular Endothelial Growth Factor (VEGF) and NF-kappaB.	gamma-sitosterol	0-15	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	84-89
32945205-9	2020	beta-sitosterol-SLN significantly (p < .001) reduced the level of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), vascular Endothelial Growth Factor (VEGF) and NF-kappaB.	gamma-sitosterol	0-15	vascular endothelial growth factor A	Rattus norvegicus	117-151
32945205-9	2020	beta-sitosterol-SLN significantly (p < .001) reduced the level of cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), vascular Endothelial Growth Factor (VEGF) and NF-kappaB.	gamma-sitosterol	0-15	vascular endothelial growth factor A	Rattus norvegicus	153-157
32945205-10	2020	beta-sitosterol-SLN significantly increased the expression of HO-1,Nrf2 and decreased the expression of NF-kappaB, RANKL, STAT3.	gamma-sitosterol	0-15	heme oxygenase 1	Rattus norvegicus	62-66
32945205-10	2020	beta-sitosterol-SLN significantly increased the expression of HO-1,Nrf2 and decreased the expression of NF-kappaB, RANKL, STAT3.	gamma-sitosterol	0-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	67-71
32945205-10	2020	beta-sitosterol-SLN significantly increased the expression of HO-1,Nrf2 and decreased the expression of NF-kappaB, RANKL, STAT3.	gamma-sitosterol	0-15	TNF superfamily member 11	Rattus norvegicus	115-120
32945205-10	2020	beta-sitosterol-SLN significantly increased the expression of HO-1,Nrf2 and decreased the expression of NF-kappaB, RANKL, STAT3.	gamma-sitosterol	0-15	signal transducer and activator of transcription 3	Rattus norvegicus	122-127
32945205-11	2020	In conclusion, beta-sitosterol SLN showed the antiarthritic effect via suppression of NF-kB and activation of HO-1/Nrf-2 pathway.	gamma-sitosterol	15-30	nuclear factor kappa B subunit 1	Rattus norvegicus	86-91
32945205-11	2020	In conclusion, beta-sitosterol SLN showed the antiarthritic effect via suppression of NF-kB and activation of HO-1/Nrf-2 pathway.	gamma-sitosterol	15-30	heme oxygenase 1	Rattus norvegicus	110-114
32945205-11	2020	In conclusion, beta-sitosterol SLN showed the antiarthritic effect via suppression of NF-kB and activation of HO-1/Nrf-2 pathway.	gamma-sitosterol	15-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-120
33294448-8	2020	The combination of sitosterol and CASP3 in CS, acting on "pathways in cancer" and restoring normal cell apoptosis, could be the core mechanisms of CS in the treatment of liver cancer.	gamma-sitosterol	19-29	citrate synthase	Homo sapiens	43-45
33294448-8	2020	The combination of sitosterol and CASP3 in CS, acting on "pathways in cancer" and restoring normal cell apoptosis, could be the core mechanisms of CS in the treatment of liver cancer.	gamma-sitosterol	19-29	citrate synthase	Homo sapiens	147-149
33658921-0	2020	Corrigendum: beta-Sitosterol and Gemcitabine Exhibit Synergistic Anti-Pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3beta Signaling.	gamma-sitosterol	13-28	AKT serine/threonine kinase 1	Homo sapiens	186-189
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	prostaglandin-endoperoxide synthase 1	Homo sapiens	213-218
33658921-0	2020	Corrigendum: beta-Sitosterol and Gemcitabine Exhibit Synergistic Anti-Pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3beta Signaling.	gamma-sitosterol	13-28	glycogen synthase kinase 3 alpha	Homo sapiens	190-199
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	estrogen receptor 1	Homo sapiens	220-224
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	progesterone receptor	Homo sapiens	230-233
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	cholinergic receptor muscarinic 3	Homo sapiens	235-240
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	peroxisome proliferator activated receptor gamma	Homo sapiens	242-247
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	cholinergic receptor muscarinic 2	Homo sapiens	249-254
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	BCL2 apoptosis regulator	Homo sapiens	256-260
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	caspase 3	Homo sapiens	262-267
33204288-10	2020	The compounds-targets network analysis indicated that the 6 compounds, including quercetin, kaempferol, baicalein, wogonin, beta-sitosterol, and eugenol, were linked to >=10 target genes, and the 10 target genes (PTGS1, ESR1, AR, PGR, CHRM3, PPARG, CHRM2, BCL2, CASP3, and RELA) were core target genes in the network.	gamma-sitosterol	124-139	RELA proto-oncogene, NF-kB subunit	Homo sapiens	273-277
33155166-11	2020	Furthermore, beta-sitosterol downregulated the expression of apoptosis-related genes through the PI3K/Akt pathway.	gamma-sitosterol	13-28	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
33073699-7	2022	The results suggested that amarogentin, eufoliatorin, alpha-amyrin, caesalpinins, kutkin, beta-sitosterol, and belladonnine are the top-ranked molecules have the highest affinity towards both the spike glycoprotein and ACE2.	gamma-sitosterol	90-105	angiotensin converting enzyme 2	Homo sapiens	219-223
32738021-8	2020	Moreover, campesterol and beta-sitosterol were negatively correlated with body mass index, fasting insulin, and C-reactive protein and were positively correlated with HDL-cholesterol.	gamma-sitosterol	26-41	insulin	Homo sapiens	99-106
32738021-8	2020	Moreover, campesterol and beta-sitosterol were negatively correlated with body mass index, fasting insulin, and C-reactive protein and were positively correlated with HDL-cholesterol.	gamma-sitosterol	26-41	C-reactive protein	Homo sapiens	112-130
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	59-74	prostaglandin-endoperoxide synthase 1	Homo sapiens	113-118
32862661-7	2020	Homozygous LoF variants in either ABCG5 or ABCG8 led to marked elevations in sitosterol and LDL-C. Of those sitosterolemia families, heterozygous carriers of ABCG5 LoF variants exhibited increased sitosterol and LDL-C levels compared to non-carriers.	gamma-sitosterol	77-87	ATP binding cassette subfamily G member 8	Homo sapiens	43-48
32862661-7	2020	Homozygous LoF variants in either ABCG5 or ABCG8 led to marked elevations in sitosterol and LDL-C. Of those sitosterolemia families, heterozygous carriers of ABCG5 LoF variants exhibited increased sitosterol and LDL-C levels compared to non-carriers.	gamma-sitosterol	77-87	ATP binding cassette subfamily G member 5	Homo sapiens	158-163
32862661-7	2020	Homozygous LoF variants in either ABCG5 or ABCG8 led to marked elevations in sitosterol and LDL-C. Of those sitosterolemia families, heterozygous carriers of ABCG5 LoF variants exhibited increased sitosterol and LDL-C levels compared to non-carriers.	gamma-sitosterol	108-118	ATP binding cassette subfamily G member 5	Homo sapiens	34-39
32862661-7	2020	Homozygous LoF variants in either ABCG5 or ABCG8 led to marked elevations in sitosterol and LDL-C. Of those sitosterolemia families, heterozygous carriers of ABCG5 LoF variants exhibited increased sitosterol and LDL-C levels compared to non-carriers.	gamma-sitosterol	108-118	ATP binding cassette subfamily G member 5	Homo sapiens	158-163
32862661-11	2020	Conclusions - Although familial sitosterolemia is traditionally considered as a recessive disorder, we observed that heterozygous carriers of a LoF variantin ABCG5 had significantly increased sitosterol and LDL-C levels and a two-fold increase in risk of CAD.	gamma-sitosterol	32-42	ATP binding cassette subfamily G member 5	Homo sapiens	158-163
32504068-0	2020	beta-sitosterol ameliorates influenza A virus-induced proinflammatory response and acute lung injury in mice by disrupting the cross-talk between RIG-I and IFN/STAT signaling.	gamma-sitosterol	0-15	DEAD/H box helicase 58	Mus musculus	146-151
32504068-3	2020	We demonstrate that beta-sitosterol (150-450 mug/mL) dose-dependently suppresses inflammatory response through NF-kappaB and p38 mitogen-activated protein kinase (MAPK) signaling in influenza A virus (IAV)-infected cells, which was accompanied by decreased induction of interferons (IFNs) (including Type I and III IFN).	gamma-sitosterol	20-35	nuclear factor kappa B subunit 1	Homo sapiens	111-120
32504068-3	2020	We demonstrate that beta-sitosterol (150-450 mug/mL) dose-dependently suppresses inflammatory response through NF-kappaB and p38 mitogen-activated protein kinase (MAPK) signaling in influenza A virus (IAV)-infected cells, which was accompanied by decreased induction of interferons (IFNs) (including Type I and III IFN).	gamma-sitosterol	20-35	mitogen-activated protein kinase 14	Homo sapiens	125-161
32504068-4	2020	Furthermore, we revealed that the anti-inflammatory effect of beta-sitosterol resulted from its inhibitory effect on retinoic acid-inducible gene I (RIG-I) signaling, led to decreased STAT1 signaling, thus affecting the transcriptional activity of ISGF3 (interferon-stimulated gene factor 3) complexes and resulting in abrogation of the IAV-induced proinflammatory amplification effect in IFN-sensitized cells.	gamma-sitosterol	62-77	DExD/H-box helicase 58	Homo sapiens	149-154
32504068-4	2020	Furthermore, we revealed that the anti-inflammatory effect of beta-sitosterol resulted from its inhibitory effect on retinoic acid-inducible gene I (RIG-I) signaling, led to decreased STAT1 signaling, thus affecting the transcriptional activity of ISGF3 (interferon-stimulated gene factor 3) complexes and resulting in abrogation of the IAV-induced proinflammatory amplification effect in IFN-sensitized cells.	gamma-sitosterol	62-77	signal transducer and activator of transcription 1	Homo sapiens	184-189
32504068-4	2020	Furthermore, we revealed that the anti-inflammatory effect of beta-sitosterol resulted from its inhibitory effect on retinoic acid-inducible gene I (RIG-I) signaling, led to decreased STAT1 signaling, thus affecting the transcriptional activity of ISGF3 (interferon-stimulated gene factor 3) complexes and resulting in abrogation of the IAV-induced proinflammatory amplification effect in IFN-sensitized cells.	gamma-sitosterol	62-77	signal transducer and activator of transcription 1	Homo sapiens	248-253
32504068-5	2020	Moreover, beta-sitosterol treatment attenuated RIG-I-mediated apoptotic injury of alveolar epithelial cells (AEC) via downregulation of pro-apoptotic factors.	gamma-sitosterol	10-25	DExD/H-box helicase 58	Homo sapiens	47-52
32504068-8	2020	Our data suggest that beta-sitosterol blocks the immune response mediated by RIG-I signaling and deleterious IFN production, providing a potential benefit for the treatment of influenza.	gamma-sitosterol	22-37	DExD/H-box helicase 58	Homo sapiens	77-82
32862661-2	2020	Affected individuals typically have complete genetic deficiency - homozygous loss-of-function (LoF) variants - in the ATP-binding cassette transporter G5 (ABCG5) or G8 (ABCG8) genes and have substantially elevated plasma sitosterol and low-density lipoprotein cholesterol (LDL-C) levels.	gamma-sitosterol	221-231	ATP binding cassette subfamily G member 5	Homo sapiens	155-160
32862661-2	2020	Affected individuals typically have complete genetic deficiency - homozygous loss-of-function (LoF) variants - in the ATP-binding cassette transporter G5 (ABCG5) or G8 (ABCG8) genes and have substantially elevated plasma sitosterol and low-density lipoprotein cholesterol (LDL-C) levels.	gamma-sitosterol	221-231	ATP binding cassette subfamily G member 8	Homo sapiens	169-174
32862661-7	2020	Homozygous LoF variants in either ABCG5 or ABCG8 led to marked elevations in sitosterol and LDL-C. Of those sitosterolemia families, heterozygous carriers of ABCG5 LoF variants exhibited increased sitosterol and LDL-C levels compared to non-carriers.	gamma-sitosterol	77-87	ATP binding cassette subfamily G member 5	Homo sapiens	34-39
32319188-0	2020	beta-sitosterol assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line.	gamma-sitosterol	0-15	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
32830144-6	2020	In HepG2 cells, paeonol, quercetin, beta-sitosterol, and gallic acid play a defensive role against H2O2-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties.	gamma-sitosterol	36-51	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
32830144-6	2020	In HepG2 cells, paeonol, quercetin, beta-sitosterol, and gallic acid play a defensive role against H2O2-induced oxidative stress through activating Nrf2/Keap1 pathway, indicating that these monomers have anti-oxidative properties.	gamma-sitosterol	36-51	kelch like ECH associated protein 1	Homo sapiens	153-158
32845916-4	2020	METHODS: Gas chromatography-mass spectrometry was utilized to measure sitosterol levels of normocholesterolemic and hypercholesterolemic children.	gamma-sitosterol	70-80	gastrin	Homo sapiens	9-12
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	59-74	prostaglandin-endoperoxide synthase 2	Homo sapiens	131-136
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	76-78	prostaglandin-endoperoxide synthase 1	Homo sapiens	113-118
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	76-78	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	120-125
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	76-78	prostaglandin-endoperoxide synthase 2	Homo sapiens	131-136
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	76-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	138-143
32854331-9	2020	In our network, GO and KEGG results yielded two compounds (beta-sitosterol (BS) and pelargonidin (PG)), targets (PTGS1 (COX-1) and PTGS2 (COX-2)), and pathways (nitric oxide, TNF) were involved in the inhibitory effects of FT on influenza-associated inflammation.	gamma-sitosterol	76-78	tumor necrosis factor	Homo sapiens	175-178
32922187-12	2020	NR3C2 also displayed good docking scores with Wallichilide and Sitosterol (8.13 and 8.34, respectively), revealing good binding forces to active compounds of Chuanxiong Rhizoma.	gamma-sitosterol	63-73	nuclear receptor subfamily 3 group C member 2	Homo sapiens	0-5
32596368-0	2020	beta-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERK/p38 and NF-kappaB Pathways in LPS-Exposed BV2 Cells.	gamma-sitosterol	0-15	mitogen-activated protein kinase 1	Mus musculus	82-85
32275988-0	2020	Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations.	gamma-sitosterol	6-16	ATP binding cassette subfamily G member 5	Homo sapiens	34-39
32275988-0	2020	Serum sitosterol level predicting ABCG5 or ABCG8 genetic mutations.	gamma-sitosterol	6-16	ATP binding cassette subfamily G member 8	Homo sapiens	43-48
32275988-7	2020	Under these conditions, a cutoff value of sitosterol 10 mug/ml could discriminate the patients with sitosterolemia with double mutations in ABCG5 or ABCG8 gene from no mutation carrier (wildtype control) perfectly, although 6 heterozygous mutation carries exhibited sitosterol level greater than 10 mug/ml.	gamma-sitosterol	42-52	ATP binding cassette subfamily G member 5	Homo sapiens	140-145
32275988-7	2020	Under these conditions, a cutoff value of sitosterol 10 mug/ml could discriminate the patients with sitosterolemia with double mutations in ABCG5 or ABCG8 gene from no mutation carrier (wildtype control) perfectly, although 6 heterozygous mutation carries exhibited sitosterol level greater than 10 mug/ml.	gamma-sitosterol	42-52	ATP binding cassette subfamily G member 8	Homo sapiens	149-154
32275988-7	2020	Under these conditions, a cutoff value of sitosterol 10 mug/ml could discriminate the patients with sitosterolemia with double mutations in ABCG5 or ABCG8 gene from no mutation carrier (wildtype control) perfectly, although 6 heterozygous mutation carries exhibited sitosterol level greater than 10 mug/ml.	gamma-sitosterol	100-110	ATP binding cassette subfamily G member 5	Homo sapiens	140-145
32275988-7	2020	Under these conditions, a cutoff value of sitosterol 10 mug/ml could discriminate the patients with sitosterolemia with double mutations in ABCG5 or ABCG8 gene from no mutation carrier (wildtype control) perfectly, although 6 heterozygous mutation carries exhibited sitosterol level greater than 10 mug/ml.	gamma-sitosterol	100-110	ATP binding cassette subfamily G member 8	Homo sapiens	149-154
32392637-7	2020	Moreover, LTA, CD83, and SREBF1 were 3 important targets for synergistic mechanism of IMP+STO treatment.	gamma-sitosterol	90-93	lymphotoxin alpha	Rattus norvegicus	10-13
32392637-7	2020	Moreover, LTA, CD83, and SREBF1 were 3 important targets for synergistic mechanism of IMP+STO treatment.	gamma-sitosterol	90-93	CD83 molecule	Rattus norvegicus	15-19
32392637-7	2020	Moreover, LTA, CD83, and SREBF1 were 3 important targets for synergistic mechanism of IMP+STO treatment.	gamma-sitosterol	90-93	sterol regulatory element binding transcription factor 1	Rattus norvegicus	25-31
32124158-0	2020	Effect of beta-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of PPRgamma and glucose transporter 4 in high fat diet and streptozotocin-induced diabetic rats.	gamma-sitosterol	10-25	solute carrier family 2 member 4	Rattus norvegicus	136-157
32124158-2	2020	But no studies have been reported the effect of beta-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and glucose transporter 4 (GLUT4) in insulin dependent tissues of high fat diet and streptozotocin-induced diabetic rats.	gamma-sitosterol	48-63	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	161-209
32124158-2	2020	But no studies have been reported the effect of beta-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and glucose transporter 4 (GLUT4) in insulin dependent tissues of high fat diet and streptozotocin-induced diabetic rats.	gamma-sitosterol	48-63	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	211-220
32124158-2	2020	But no studies have been reported the effect of beta-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and glucose transporter 4 (GLUT4) in insulin dependent tissues of high fat diet and streptozotocin-induced diabetic rats.	gamma-sitosterol	48-63	solute carrier family 2 member 4	Rattus norvegicus	226-247
32124158-2	2020	But no studies have been reported the effect of beta-sitosterol on glucose homeostasis by sensitization of insulin resistance via enhanced protein expression of peroxisome proliferator-activated receptor gamma (PPARgamma) and glucose transporter 4 (GLUT4) in insulin dependent tissues of high fat diet and streptozotocin-induced diabetic rats.	gamma-sitosterol	48-63	solute carrier family 2 member 4	Rattus norvegicus	249-254
32124158-7	2020	RESULTS: Upon administration of beta-sitosterol at a dose of 15 mg/kg body weight per day to high fat diet and streptozotocin induced diabetic rats for 30 days significantly decreased the levels of plasma glucose, homeostatic model assessment of insulin resistance and glycosylated hemoglobin and increased the levels of insulin, hemoglobin and protein expression of PPARgamma and GLUT4 in insulin dependent tissues.	gamma-sitosterol	32-47	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	367-376
32124158-7	2020	RESULTS: Upon administration of beta-sitosterol at a dose of 15 mg/kg body weight per day to high fat diet and streptozotocin induced diabetic rats for 30 days significantly decreased the levels of plasma glucose, homeostatic model assessment of insulin resistance and glycosylated hemoglobin and increased the levels of insulin, hemoglobin and protein expression of PPARgamma and GLUT4 in insulin dependent tissues.	gamma-sitosterol	32-47	solute carrier family 2 member 4	Rattus norvegicus	381-386
32724650-4	2020	The results showed that serum concentrations of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and total Th1 cytokines were positively associated with serum beta-sitosterol level, adjusting for age, BMI, and serum cholesterol.	gamma-sitosterol	169-184	interferon gamma	Homo sapiens	48-70
32724650-4	2020	The results showed that serum concentrations of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and total Th1 cytokines were positively associated with serum beta-sitosterol level, adjusting for age, BMI, and serum cholesterol.	gamma-sitosterol	169-184	tumor necrosis factor	Homo sapiens	72-105
31930431-3	2020	We investigated the hepatoprotective effect of BSS against carbon tetrachloride (CCl4)-induced chronic liver injury in rats.	gamma-sitosterol	47-50	C-C motif chemokine ligand 4	Rattus norvegicus	81-85
31930431-14	2020	The results suggest that BSS could have a hepatoprotective effect against oxidative stress-mediated CLD induced by CCl4.	gamma-sitosterol	25-28	C-C motif chemokine ligand 4	Rattus norvegicus	115-119
32596368-10	2020	The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2(COX-2)).	gamma-sitosterol	51-53	tumor necrosis factor	Mus musculus	182-209
32596368-10	2020	The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2(COX-2)).	gamma-sitosterol	51-53	tumor necrosis factor	Mus musculus	211-220
32596368-10	2020	The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2(COX-2)).	gamma-sitosterol	51-53	prostaglandin-endoperoxide synthase 2	Mus musculus	227-243
32596368-10	2020	The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2(COX-2)).	gamma-sitosterol	51-53	cytochrome c oxidase II, mitochondrial	Mus musculus	244-249
32596368-0	2020	beta-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERK/p38 and NF-kappaB Pathways in LPS-Exposed BV2 Cells.	gamma-sitosterol	0-15	mitogen-activated protein kinase 14	Mus musculus	86-89
32596368-0	2020	beta-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERK/p38 and NF-kappaB Pathways in LPS-Exposed BV2 Cells.	gamma-sitosterol	0-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103
32596368-10	2020	The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2(COX-2)).	gamma-sitosterol	51-53	interleukin 6	Mus musculus	129-142
32596368-10	2020	The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2(COX-2)).	gamma-sitosterol	51-53	interleukin 6	Mus musculus	144-148
32596368-10	2020	The inflammatory response results illustrated that BS treatment can reduce the LPS-induced expression of inflammatory mediators (interleukin-6 (IL-6), inducible nitric oxide (iNOS), tumor necrosis factor-alpha (TNF-alpha), and cyclooxygenase-2(COX-2)).	gamma-sitosterol	51-53	nitric oxide synthase 2, inducible	Mus musculus	175-179
32321590-0	2020	Unilateral intranigral administration of beta-sitosterol beta-D-glucoside triggers pathological alpha-synuclein spreading and bilateral nigrostriatal dopaminergic neurodegeneration in the rat.	gamma-sitosterol	41-56	synuclein alpha	Rattus norvegicus	96-111
32321590-1	2020	The spreading and accumulation of alpha-synuclein and dopaminergic neurodegeneration, two hallmarks of Parkinson"s disease (PD), have been faithfully reproduced in rodent brains by chronic, oral administration of beta-sitosterol beta-D-glucoside (BSSG).	gamma-sitosterol	213-228	synuclein alpha	Rattus norvegicus	34-49
32045603-0	2020	Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats.	gamma-sitosterol	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
32045603-1	2020	In our previous study, we have shown that beta-sitosterol (SIT) enhances glycemic control by increasing the activation of insulin receptor (IR) and glucose transporter 4 (GLUT4) proteins in adipose tissue.	gamma-sitosterol	42-57	insulin receptor	Rattus norvegicus	122-143
32045603-0	2020	Beta-sitosterol attenuates insulin resistance in adipose tissue via IRS-1/Akt mediated insulin signaling in high fat diet and sucrose induced type-2 diabetic rats.	gamma-sitosterol	0-15	insulin receptor substrate 1	Rattus norvegicus	68-73
32045603-1	2020	In our previous study, we have shown that beta-sitosterol (SIT) enhances glycemic control by increasing the activation of insulin receptor (IR) and glucose transporter 4 (GLUT4) proteins in adipose tissue.	gamma-sitosterol	42-57	solute carrier family 2 member 4	Rattus norvegicus	148-169
32045603-1	2020	In our previous study, we have shown that beta-sitosterol (SIT) enhances glycemic control by increasing the activation of insulin receptor (IR) and glucose transporter 4 (GLUT4) proteins in adipose tissue.	gamma-sitosterol	42-57	solute carrier family 2 member 4	Rattus norvegicus	171-176
32045603-1	2020	In our previous study, we have shown that beta-sitosterol (SIT) enhances glycemic control by increasing the activation of insulin receptor (IR) and glucose transporter 4 (GLUT4) proteins in adipose tissue.	gamma-sitosterol	59-62	insulin receptor	Rattus norvegicus	122-143
32045603-1	2020	In our previous study, we have shown that beta-sitosterol (SIT) enhances glycemic control by increasing the activation of insulin receptor (IR) and glucose transporter 4 (GLUT4) proteins in adipose tissue.	gamma-sitosterol	59-62	solute carrier family 2 member 4	Rattus norvegicus	148-169
32045603-1	2020	In our previous study, we have shown that beta-sitosterol (SIT) enhances glycemic control by increasing the activation of insulin receptor (IR) and glucose transporter 4 (GLUT4) proteins in adipose tissue.	gamma-sitosterol	59-62	solute carrier family 2 member 4	Rattus norvegicus	171-176
32045603-3	2020	Hence, the study was aimed to assess the effects of SIT on IRS-1/Akt mediated insulin signaling molecules in high-fat diet and sucrose induced type-2 diabetic rats.	gamma-sitosterol	52-55	insulin receptor substrate 1	Rattus norvegicus	59-64
32045603-3	2020	Hence, the study was aimed to assess the effects of SIT on IRS-1/Akt mediated insulin signaling molecules in high-fat diet and sucrose induced type-2 diabetic rats.	gamma-sitosterol	52-55	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
32045603-5	2020	The results showed that SIT attenuated the insulin receptor substrate-1 serine phosphorylation (p-IRS-1Ser636) (P = 0.0003).	gamma-sitosterol	24-27	insulin receptor substrate 1	Rattus norvegicus	43-71
32045603-7	2020	In Silico analysis was also performed and it showed that SIT possesses the greater binding affinity with beta-arrestin-2, c-Src, and IRS-1 as well as Akt proteins and proved to attenuate insulin resistance as this study coincides with in vivo findings.	gamma-sitosterol	57-60	arrestin, beta 2, pseudogene	Rattus norvegicus	105-120
32045603-7	2020	In Silico analysis was also performed and it showed that SIT possesses the greater binding affinity with beta-arrestin-2, c-Src, and IRS-1 as well as Akt proteins and proved to attenuate insulin resistance as this study coincides with in vivo findings.	gamma-sitosterol	57-60	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	122-127
32045603-7	2020	In Silico analysis was also performed and it showed that SIT possesses the greater binding affinity with beta-arrestin-2, c-Src, and IRS-1 as well as Akt proteins and proved to attenuate insulin resistance as this study coincides with in vivo findings.	gamma-sitosterol	57-60	insulin receptor substrate 1	Rattus norvegicus	133-138
32045603-7	2020	In Silico analysis was also performed and it showed that SIT possesses the greater binding affinity with beta-arrestin-2, c-Src, and IRS-1 as well as Akt proteins and proved to attenuate insulin resistance as this study coincides with in vivo findings.	gamma-sitosterol	57-60	AKT serine/threonine kinase 1	Rattus norvegicus	150-153
31517568-11	2020	beta-sitosterol alone increased plasma adiponectin concentration and reduced plasma insulin concentration and homeostatic model assessment index.	gamma-sitosterol	0-15	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	39-50
32167760-0	2020	beta-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the p53-MDM2 Interaction in Colorectal Cancer.	gamma-sitosterol	0-15	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	50-54
32308701-0	2020	beta-Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPARgamma/NF-kappaB Signalling.	gamma-sitosterol	0-15	peroxisome proliferator activated receptor gamma	Homo sapiens	86-95
32308701-0	2020	beta-Sitosterol Protects against Myocardial Ischemia/Reperfusion Injury via Targeting PPARgamma/NF-kappaB Signalling.	gamma-sitosterol	0-15	nuclear factor kappa B subunit 1	Homo sapiens	96-105
32308701-5	2020	Moreover, beta-sitosterol treatment counteracted the inhibitory effects of H/R treatment on the peroxisome proliferator-activated receptor gamma (PPARgamma) expression and enhanced effects of H/R treatment on the NF-kappaB expression in cardiomyocytes.	gamma-sitosterol	10-25	peroxisome proliferator activated receptor gamma	Homo sapiens	96-144
32308701-5	2020	Moreover, beta-sitosterol treatment counteracted the inhibitory effects of H/R treatment on the peroxisome proliferator-activated receptor gamma (PPARgamma) expression and enhanced effects of H/R treatment on the NF-kappaB expression in cardiomyocytes.	gamma-sitosterol	10-25	peroxisome proliferator activated receptor gamma	Homo sapiens	146-155
32308701-5	2020	Moreover, beta-sitosterol treatment counteracted the inhibitory effects of H/R treatment on the peroxisome proliferator-activated receptor gamma (PPARgamma) expression and enhanced effects of H/R treatment on the NF-kappaB expression in cardiomyocytes.	gamma-sitosterol	10-25	nuclear factor kappa B subunit 1	Homo sapiens	213-222
32308701-6	2020	Furthermore, inhibition of PPARgamma impaired the protective actions of beta-sitosterol against H/R-induced cardiomyocyte injury.	gamma-sitosterol	72-87	peroxisome proliferator activated receptor gamma	Homo sapiens	27-36
32308701-7	2020	In the I/R rats, beta-sitosterol treatment reduced the myocardial infarcted size and apoptosis, which was attenuated by the inhibition of PPARgamma.	gamma-sitosterol	17-32	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	138-147
32308701-9	2020	The beta-sitosterol-mediated cardioprotective effects may involve the modulation of PPARgamma/NF-kappaB signalling during myocardial I/R injury.	gamma-sitosterol	4-19	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	84-93
32308701-9	2020	The beta-sitosterol-mediated cardioprotective effects may involve the modulation of PPARgamma/NF-kappaB signalling during myocardial I/R injury.	gamma-sitosterol	4-19	nuclear factor kappa B subunit 1	Homo sapiens	94-103
32167760-0	2020	beta-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the p53-MDM2 Interaction in Colorectal Cancer.	gamma-sitosterol	0-15	transformation related protein 53, pseudogene	Mus musculus	85-88
32167760-0	2020	beta-Sitosterol Reverses Multidrug Resistance via BCRP Suppression by Inhibiting the p53-MDM2 Interaction in Colorectal Cancer.	gamma-sitosterol	0-15	transformed mouse 3T3 cell double minute 2	Mus musculus	89-93
32167760-3	2020	Here, we demonstrated that beta-sitosterol, the most common dietary phytosterol, recovers oxaliplatin (OXA) sensitivity in drug-resistant colorectal cancer (CRC) cells by inhibiting breast cancer resistance protein (BCRP) expression.	gamma-sitosterol	27-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	182-214
32167760-3	2020	Here, we demonstrated that beta-sitosterol, the most common dietary phytosterol, recovers oxaliplatin (OXA) sensitivity in drug-resistant colorectal cancer (CRC) cells by inhibiting breast cancer resistance protein (BCRP) expression.	gamma-sitosterol	27-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	216-220
32167760-4	2020	We further showed evidence that beta-sitosterol could activate p53 by disrupting the p53-MDM2 interaction, leading to an increase in p53 translocation to the nucleus and silencing the nuclear factor-kappaB (NF-kappaB) pathway, which is necessary for BCRP expression.	gamma-sitosterol	32-47	transformation related protein 53, pseudogene	Mus musculus	63-66
32167760-4	2020	We further showed evidence that beta-sitosterol could activate p53 by disrupting the p53-MDM2 interaction, leading to an increase in p53 translocation to the nucleus and silencing the nuclear factor-kappaB (NF-kappaB) pathway, which is necessary for BCRP expression.	gamma-sitosterol	32-47	transformation related protein 53, pseudogene	Mus musculus	85-88
32167760-4	2020	We further showed evidence that beta-sitosterol could activate p53 by disrupting the p53-MDM2 interaction, leading to an increase in p53 translocation to the nucleus and silencing the nuclear factor-kappaB (NF-kappaB) pathway, which is necessary for BCRP expression.	gamma-sitosterol	32-47	transformed mouse 3T3 cell double minute 2	Mus musculus	89-93
32167760-4	2020	We further showed evidence that beta-sitosterol could activate p53 by disrupting the p53-MDM2 interaction, leading to an increase in p53 translocation to the nucleus and silencing the nuclear factor-kappaB (NF-kappaB) pathway, which is necessary for BCRP expression.	gamma-sitosterol	32-47	transformation related protein 53, pseudogene	Mus musculus	85-88
32167760-4	2020	We further showed evidence that beta-sitosterol could activate p53 by disrupting the p53-MDM2 interaction, leading to an increase in p53 translocation to the nucleus and silencing the nuclear factor-kappaB (NF-kappaB) pathway, which is necessary for BCRP expression.	gamma-sitosterol	32-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	184-205
32167760-4	2020	We further showed evidence that beta-sitosterol could activate p53 by disrupting the p53-MDM2 interaction, leading to an increase in p53 translocation to the nucleus and silencing the nuclear factor-kappaB (NF-kappaB) pathway, which is necessary for BCRP expression.	gamma-sitosterol	32-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	207-216
32167760-4	2020	We further showed evidence that beta-sitosterol could activate p53 by disrupting the p53-MDM2 interaction, leading to an increase in p53 translocation to the nucleus and silencing the nuclear factor-kappaB (NF-kappaB) pathway, which is necessary for BCRP expression.	gamma-sitosterol	32-47	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	250-254
32167760-6	2020	These results revealed that beta-sitosterol is able to mediate the p53/NF-kappaB/BCRP signaling axis to regulate the response of CRC to chemotherapy.	gamma-sitosterol	28-43	transformation related protein 53, pseudogene	Mus musculus	67-70
32167760-6	2020	These results revealed that beta-sitosterol is able to mediate the p53/NF-kappaB/BCRP signaling axis to regulate the response of CRC to chemotherapy.	gamma-sitosterol	28-43	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	71-80
32167760-6	2020	These results revealed that beta-sitosterol is able to mediate the p53/NF-kappaB/BCRP signaling axis to regulate the response of CRC to chemotherapy.	gamma-sitosterol	28-43	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	81-85
32062961-9	2020	Molecular mechanisms showed that MOO and beta-Sitosterol significantly upregulated the amount of protein-level expression of Glu decarboxylase-65 (GAD65) and alpha1-subunit of GABAA receptors in the hypothalamus of mice, not affecting GAD67, gamma2 subunits.	gamma-sitosterol	41-56	glutamic acid decarboxylase 2	Mus musculus	147-152
32131509-2	2020	The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in vivo inhibition of SMT2, a plant sterol-C-methyltransferase acting as a branch point between the campesterol and sitosterol biosynthetic segments in the pathway.	gamma-sitosterol	231-241	sterol methyltransferase 2	Arabidopsis thaliana	137-141
32062961-9	2020	Molecular mechanisms showed that MOO and beta-Sitosterol significantly upregulated the amount of protein-level expression of Glu decarboxylase-65 (GAD65) and alpha1-subunit of GABAA receptors in the hypothalamus of mice, not affecting GAD67, gamma2 subunits.	gamma-sitosterol	41-56	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	242-248
32111314-6	2020	Compared with the control group, dietary beta-sitosterol at higher than or equal to 60 mg/kg level decreased (P < 0.05) contents of serum total cholesterol, ileal MDA, and jejunal TLR4 mRNA relative expression level, whereas it increased (P < 0.05) absolute spleen weight and ileal glutathione content.	gamma-sitosterol	41-56	toll like receptor 4	Gallus gallus	180-184
32111314-7	2020	Higher than or equal to 80 mg/kg level of beta-sitosterol enhanced (P < 0.05) jejunal IgG concentration, VH, catalase activity, and Nrf2 relative expression level and ileal secreted IgA content, but reduced (P < 0.05) ileal IL-1beta content and MyD88 mRNA relative expression level.	gamma-sitosterol	42-57	interleukin 1, beta	Gallus gallus	224-232
32111314-7	2020	Higher than or equal to 80 mg/kg level of beta-sitosterol enhanced (P < 0.05) jejunal IgG concentration, VH, catalase activity, and Nrf2 relative expression level and ileal secreted IgA content, but reduced (P < 0.05) ileal IL-1beta content and MyD88 mRNA relative expression level.	gamma-sitosterol	42-57	myeloid differentiation primary response 88	Gallus gallus	245-250
32111314-9	2020	Moreover, 100 mg/kg level of beta-sitosterol reduced (P < 0.05) jejunal TNF-alpha level, but it increased (P < 0.05) VH in the jejunum and VH:CD in the jejunum and ileum.	gamma-sitosterol	29-44	lipopolysaccharide induced TNF factor	Gallus gallus	72-81
32079105-8	2020	Furthermore, two ligands, beta-sitosterol and juglanin, were predicted to bind favourably to 5-HT2C outside of the known agonist binding pocket in the active receptor, suggesting that such ligands may serve as positive allosteric modulators of 5-HT2C receptor function.	gamma-sitosterol	26-41	5-hydroxytryptamine receptor 2C	Homo sapiens	93-99
31347760-0	2020	The anti-fungal beta-sitosterol targets the yeast oxysterol-binding protein Osh4.	gamma-sitosterol	16-31	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	76-80
31347760-4	2020	RESULTS: beta-Sitosterol (200 mug mL-1 ) is toxic against yeast cells expressing only Osh4 (an oxysterol-binding protein) and harbouring a upc2-1 mutation (which enables sterol uptake), but not against yeast strains expressing all seven Osh proteins and harbouring a upc2-1 mutation.	gamma-sitosterol	9-24	L1 cell adhesion molecule	Mus musculus	34-38
31347760-4	2020	RESULTS: beta-Sitosterol (200 mug mL-1 ) is toxic against yeast cells expressing only Osh4 (an oxysterol-binding protein) and harbouring a upc2-1 mutation (which enables sterol uptake), but not against yeast strains expressing all seven Osh proteins and harbouring a upc2-1 mutation.	gamma-sitosterol	9-24	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	86-90
31347760-6	2020	The deletion of COQ1 (a gene known to be highly induced upon deletion of OSH4) enhances the toxicity of beta-sitosterol in yeast cells expressing only Osh4 and harbouring the upc2-1 mutation.	gamma-sitosterol	104-119	trans-hexaprenyltranstransferase	Saccharomyces cerevisiae S288C	16-20
31347760-6	2020	The deletion of COQ1 (a gene known to be highly induced upon deletion of OSH4) enhances the toxicity of beta-sitosterol in yeast cells expressing only Osh4 and harbouring the upc2-1 mutation.	gamma-sitosterol	104-119	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	73-77
31347760-6	2020	The deletion of COQ1 (a gene known to be highly induced upon deletion of OSH4) enhances the toxicity of beta-sitosterol in yeast cells expressing only Osh4 and harbouring the upc2-1 mutation.	gamma-sitosterol	104-119	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	151-155
31347760-7	2020	Molecular modelling suggests that beta-sitosterol binds to Osh4 and the binding mode is similar to the binding of cholesterol to Osh4.	gamma-sitosterol	34-49	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	59-63
31347760-7	2020	Molecular modelling suggests that beta-sitosterol binds to Osh4 and the binding mode is similar to the binding of cholesterol to Osh4.	gamma-sitosterol	34-49	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	129-133
31347760-8	2020	CONCLUSION: Our results indicate that the concentrations of beta-sitosterol, and Osh4, as well as its homologues within cells, are most likely the main determinants of beta-sitosterol toxicity.	gamma-sitosterol	168-183	oxysterol-binding protein KES1	Saccharomyces cerevisiae S288C	81-85
31963945-7	2020	The data showed that compared with control group, Dietary BSS supplementation decreased serum concentrations of tumor necrosis factor, interleukin (IL)-6, and IL-1beta.	gamma-sitosterol	58-61	interleukin-6	Ovis aries	135-153
31963945-7	2020	The data showed that compared with control group, Dietary BSS supplementation decreased serum concentrations of tumor necrosis factor, interleukin (IL)-6, and IL-1beta.	gamma-sitosterol	58-61	interleukin-1 alpha	Ovis aries	159-167