PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2782647-1	1989	Catecholamine and renin-angiotensin responses to enflurane- or isoflurane-hypotensive anesthesia were compared in a randomized study.	Enflurane	49-58	renin	Homo sapiens	18-23
15815270-0	1989	Concentration-related changes in the rate of CSF formation and resistance to reabsorption of CSF during enflurane and isoflurane anesthesia in dogs.	Enflurane	104-113	colony stimulating factor 2	Canis lupus familiaris	45-48
2572247-0	1989	Enflurane-induced burst discharge of hippocampal CA1 neurones is blocked by the NMDA receptor antagonist APV.	Enflurane	0-9	carbonic anhydrase 1	Rattus norvegicus	49-52
2572247-2	1989	Enflurane produced seizure-like burst discharges in CA1 pyramidal neurones, accompanied by depressed field potential amplitudes and a reduced threshold for synaptically evoked population spikes.	Enflurane	0-9	carbonic anhydrase 1	Rattus norvegicus	52-55
2572247-4	1989	Enflurane 2.0 vol% hyperpolarized CA1 neurones (3.1 (SD 1.3)mV), decreased membrane conductance (12 (6)% below control), and depressed EPSP amplitudes (34% of control) (P less than 0.01).	Enflurane	0-9	carbonic anhydrase 1	Rattus norvegicus	34-37
2572247-7	1989	Thus enflurane-induced burst discharge of CA1 neurones appeared to involve an enhancement of excitatory synaptic transmission rather than depression of intrinsic or synaptic inhibition.	Enflurane	5-14	carbonic anhydrase 1	Rattus norvegicus	42-45
2765333-0	1989	Ethanol-inducible cytochrome P450 in rabbits metabolizes enflurane.	Enflurane	57-66	cytochrome P-450	Oryctolagus cuniculus	18-33
2765333-1	1989	Following anaesthesia with enflurane, some patients receiving isoniazid have increased serum concentrations of fluoride ion, presumably because of induction of an isozyme of cytochrome P450 which is responsible for enflurane biodegradation.	Enflurane	27-36	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	174-189
2765333-1	1989	Following anaesthesia with enflurane, some patients receiving isoniazid have increased serum concentrations of fluoride ion, presumably because of induction of an isozyme of cytochrome P450 which is responsible for enflurane biodegradation.	Enflurane	215-224	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	174-189
2765333-2	1989	In rats, isoniazid and ethanol enhance metabolism of enflurane and also induce a form of cytochrome P450 which is homologous with a form of rabbit liver cytochrome P450 known as 3a.	Enflurane	53-62	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	89-104
2765333-2	1989	In rats, isoniazid and ethanol enhance metabolism of enflurane and also induce a form of cytochrome P450 which is homologous with a form of rabbit liver cytochrome P450 known as 3a.	Enflurane	53-62	cytochrome P-450	Oryctolagus cuniculus	153-168
2765333-6	1989	Polyclonal antibodies to cytochrome P450 3a inhibited 90% of enflurane metabolism, but only 40% of methoxyflurane biotransformation in the microsomes from imidazole-pretreated rabbits.	Enflurane	61-70	cytochrome P-450	Oryctolagus cuniculus	25-40
2765333-7	1989	Thus isozyme 3a or a structurally similar cytochrome P450 seemed to catalyse almost all microsomal metabolism of enflurane.	Enflurane	113-122	cytochrome P-450	Oryctolagus cuniculus	42-57
2765333-8	1989	In addition, purified cytochrome P450 3a catalysed the metabolism of enflurane, sevoflurane and methoxyflurane, and the oxidation of these anaesthetics by cytochrome P450 3a was stimulated four-fold by cytochrome b5, a protein which serves as an alternate source of electrons for some cytochrome P450 reactions.	Enflurane	69-78	cytochrome P-450	Oryctolagus cuniculus	22-37
2765333-8	1989	In addition, purified cytochrome P450 3a catalysed the metabolism of enflurane, sevoflurane and methoxyflurane, and the oxidation of these anaesthetics by cytochrome P450 3a was stimulated four-fold by cytochrome b5, a protein which serves as an alternate source of electrons for some cytochrome P450 reactions.	Enflurane	69-78	cytochrome P-450	Oryctolagus cuniculus	155-170
2765333-8	1989	In addition, purified cytochrome P450 3a catalysed the metabolism of enflurane, sevoflurane and methoxyflurane, and the oxidation of these anaesthetics by cytochrome P450 3a was stimulated four-fold by cytochrome b5, a protein which serves as an alternate source of electrons for some cytochrome P450 reactions.	Enflurane	69-78	cytochrome b5	Oryctolagus cuniculus	202-215
2765333-8	1989	In addition, purified cytochrome P450 3a catalysed the metabolism of enflurane, sevoflurane and methoxyflurane, and the oxidation of these anaesthetics by cytochrome P450 3a was stimulated four-fold by cytochrome b5, a protein which serves as an alternate source of electrons for some cytochrome P450 reactions.	Enflurane	69-78	cytochrome P-450	Oryctolagus cuniculus	155-170
2597363-0	1989	Responses of vasopressin release in patients with cardiopulmonary bypass anesthetized with enflurane and morphine.	Enflurane	91-100	arginine vasopressin	Homo sapiens	13-24
15815270-0	1989	Concentration-related changes in the rate of CSF formation and resistance to reabsorption of CSF during enflurane and isoflurane anesthesia in dogs.	Enflurane	104-113	colony stimulating factor 2	Canis lupus familiaris	93-96
2837263-4	1988	Enflurane also increased CA1 excitability (0.5-4.0 vol%), but depressed synaptic responses at equivalent concentrations, and produced mixed excitatory (0.25-1.0 vol%) and depressant (1.0-4.0 vol%) effects on dentate synaptic responses.	Enflurane	0-9	carbonic anhydrase 1	Homo sapiens	25-28
2496439-0	1989	Respiratory and cardiovascular effects of thyrotropin-releasing hormone as modified by isoflurane, enflurane, pentobarbital and ketamine.	Enflurane	99-108	thyrotropin releasing hormone	Rattus norvegicus	42-71
2496439-11	1989	Significant respiratory depression in the enflurane group was rapidly reversed by TRH.	Enflurane	42-51	thyrotropin releasing hormone	Rattus norvegicus	82-85
2899408-0	1988	The increase in urinary alanine aminopeptidase excretion associated with enflurane anesthesia is increased further by aminoglycosides.	Enflurane	73-82	carboxypeptidase Q	Homo sapiens	32-46
3236239-2	1988	The effects of the volatile anaesthetics, halothane, isoflurane and enflurane, on rat hippocampal CA1 and CA3 neurones in in vitro preparations were studied by intracellular recording methods.	Enflurane	68-77	carbonic anhydrase 1	Rattus norvegicus	98-101
15235845-5	1988	The percentage incidence of opisthotonus was 93% for sevoflurane, 81% for isoflurane, 64% for enflurane, 17% for methoxyflurane and 2% for halothane.	Enflurane	94-103	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	28-40
3369717-5	1988	While LCGU, in most structures, decreased in a dose-related manner, LCGU in the corpus callosum, thalamic ventrobasal complex, and hippocampal CA3 field during 4% enflurane increased by 31-70%, compared with that during 0.5% and/or 2% enflurane.	Enflurane	163-172	carbonic anhydrase 3	Rattus norvegicus	143-146
15235845-7	1988	There was no age related susceptibility difference to anesthetic-induced opisthotonus, except for enflurane, in which the incidence of opisthotonus was higher in the aged group.	Enflurane	98-107	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	135-147
3345272-0	1988	Plasma glutathione S-transferase concentration as a measure of hepatocellular integrity following a single general anaesthetic with halothane, enflurane or isoflurane.	Enflurane	143-152	glutathione S-transferase kappa 1	Homo sapiens	7-32
3345272-1	1988	The plasma concentration of hepatic glutathione S-transferase (GST) was measured in matched groups of patients who received halothane, enflurane or isoflurane anaesthesia for elective minor surgery.	Enflurane	135-144	glutathione S-transferase kappa 1	Homo sapiens	63-66
3345272-2	1988	The GST concentrations increased significantly at 3 h after anaesthesia in patients who received halothane or enflurane, but not in patients who were given isoflurane.	Enflurane	110-119	glutathione S-transferase kappa 1	Homo sapiens	4-7
3345272-3	1988	A secondary increase in GST concentration, at 24 h, was seen in a small number of individuals who received halothane or enflurane.	Enflurane	120-129	glutathione S-transferase kappa 1	Homo sapiens	24-27
3345272-4	1988	Abnormal GST concentrations were found in 50% of patients following halothane anaesthesia, 20% following enflurane and 11% after isoflurane.	Enflurane	105-114	glutathione S-transferase kappa 1	Homo sapiens	9-12
3345272-5	1988	The small but significant increases in GST concentrations in patients receiving halothane or enflurane suggests an impairment of hepatocellular integrity following the administration of these anaesthetics.	Enflurane	93-102	glutathione S-transferase kappa 1	Homo sapiens	39-42
3947389-0	1986	The interaction of enflurane, halothane and the halothane metabolite trifluoroacetic acid with the binding of acidic drugs to human serum albumin.	Enflurane	19-28	albumin	Homo sapiens	132-145
3828186-0	1987	Enflurane-induced burst firing of hippocampal CA 1 neurones.	Enflurane	0-9	carbonic anhydrase 1	Rattus norvegicus	46-50
3828186-4	1987	Enflurane altered synaptic transmission in the in vitro rat hippocampal slice preparation and produced seizure-like burst discharges of CA 1 neurones, at vapour concentrations equivalent to those obtained during anaesthesia (2-6 vol%; 0.5-1.5 mmol litre-1).	Enflurane	0-9	carbonic anhydrase 1	Rattus norvegicus	136-140
3828186-8	1987	Input/output analyses of field excitatory post-synaptic potential (EPSP) and population spike amplitudes revealed that the enflurane-induced depression of field potential responses was associated with decreases in synaptic input, whereas burst activity resulted from a decrease in the threshold of CA 1 neurones.	Enflurane	123-132	carbonic anhydrase 1	Rattus norvegicus	298-302
3806937-0	1986	[Enflurane reduces the inhibition of dorsal horn lamina V type neuronal activity induced by bradykinin injection into the femoral artery contralateral to the recording site].	Enflurane	1-10	kininogen 1	Homo sapiens	92-102
3674476-0	1987	Opisthotonus during exposure to isoflurane, enflurane, and halothane in mice.	Enflurane	44-53	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	0-12
3674476-4	1987	A significantly lower incidence of opisthotonus was observed in all 14 strains studied when 2.0% enflurane was used.	Enflurane	97-106	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	35-47
3627285-5	1987	Enflurane and pentobarbital significantly inhibited the histamine depletion induced by alpha-fluoromethylhistidine (50 mg/kg, intraperitoneally), a specific inhibitor of histidine decarboxylase, suggesting that these agents decrease the histamine turnover.	Enflurane	0-9	histidine decarboxylase	Mus musculus	170-193
6413725-0	1983	[Influences of TRH and doxapram on the depressed human performance under sub-anesthetic enflurane inhalation].	Enflurane	88-97	thyrotropin releasing hormone	Homo sapiens	15-18
3753829-3	1986	Patients receiving enflurane anesthesia required atracurium at an infusion rate of 4.9 +/- 0.3 micrograms X kg-1 X min-1 which was a significantly lower rate (P = 0.0001) than those anesthetized with halothane (8.3 +/- 0.4 micrograms X kg-1 X min-1) or with N2O:O2 and narcotic (9.3 +/- 0.5 micrograms X kg-1 X min-1).	Enflurane	19-28	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
3753829-3	1986	Patients receiving enflurane anesthesia required atracurium at an infusion rate of 4.9 +/- 0.3 micrograms X kg-1 X min-1 which was a significantly lower rate (P = 0.0001) than those anesthetized with halothane (8.3 +/- 0.4 micrograms X kg-1 X min-1) or with N2O:O2 and narcotic (9.3 +/- 0.5 micrograms X kg-1 X min-1).	Enflurane	19-28	CD59 molecule (CD59 blood group)	Homo sapiens	243-248
3753829-3	1986	Patients receiving enflurane anesthesia required atracurium at an infusion rate of 4.9 +/- 0.3 micrograms X kg-1 X min-1 which was a significantly lower rate (P = 0.0001) than those anesthetized with halothane (8.3 +/- 0.4 micrograms X kg-1 X min-1) or with N2O:O2 and narcotic (9.3 +/- 0.5 micrograms X kg-1 X min-1).	Enflurane	19-28	CD59 molecule (CD59 blood group)	Homo sapiens	243-248
4027657-1	1985	The effects of halothane, isoflurane and enflurane on the rat hippocampal CA1 neurons in in vitro preparations were studied by intracellular recordings.	Enflurane	41-50	carbonic anhydrase 1	Rattus norvegicus	74-77
6859583-0	1983	Relationship between cerebral blood volume and CSF pressure during anesthesia with halothane or enflurane in dogs.	Enflurane	96-105	colony stimulating factor 2	Canis lupus familiaris	47-50
4069417-0	1985	[Behavior of GH and prolactin during enflurane anesthesia and neuroleptoanesthesia in man].	Enflurane	37-46	prolactin	Homo sapiens	20-29
4069417-1	1985	The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.	Enflurane	91-100	growth hormone 1	Homo sapiens	141-155
4069417-1	1985	The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.	Enflurane	91-100	prolactin	Homo sapiens	165-174
4069417-1	1985	The present study was designed to investigate the effects of neuraleptanesthesia (NLA) and enflurane (Ethane) anesthesia on plasma levels of growth hormone (GH) and prolactin (PRL) in man.	Enflurane	91-100	prolactin	Homo sapiens	176-179
4069417-12	1985	In conclusion NLA and enflurane induced a decrease of GH and PRL plasma levels; in both groups the anaesthetic agents, at the dosage used during anaesthesia, blocked the response of these hormones to the surgical stress likely due to a block of the hypothalamic-pituitary response.	Enflurane	22-31	prolactin	Homo sapiens	61-64
7139395-0	1982	Arginine vasopressin response to anaesthesia produced by halothane, enflurane and isoflurane.	Enflurane	68-77	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	0-20
6219597-1	1983	Three-week-old CD-1 mice infected with the PR-8 (mouse-adapted) strain of influenza virus while exposed to enflurane demonstrated a decrease in virus titers from the lungs of infected animals, less abnormality of lung histology, and an increase in survival in animals as compared with those receiving the other anesthetics tested.	Enflurane	107-116	CD1 antigen complex	Mus musculus	15-19
7139395-3	1982	Ten rabbits were studied to determine the response of plasma AVP to a predetermined time/concentration "dose" of halothane, enflurane or isoflurane.	Enflurane	124-133	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	61-64
7109827-1	1982	Exposure of rats to the volatile anesthetics, halothane, enflurane and isoflurane and low FIO2 (0.8%) for two hours results in a transient induction of ODC appearing maximally four hours after exposure.	Enflurane	57-66	ornithine decarboxylase 1	Rattus norvegicus	152-155
6797886-0	1981	[Effect of halothane and enflurane general anesthesia on adenosine deaminase activity in human lymphocytes].	Enflurane	25-34	adenosine deaminase	Homo sapiens	57-76
7293219-8	1981	Dehalogenation of enflurane, which is the preferred pathway, is affected to the same extent as the cytochrome P-450-dependent hydroxylation of halothane and the O-dealkylation of methoxyflurane.	Enflurane	18-27	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	99-115
7020889-7	1981	These findings suggest that insulin secretion in response to hyperglycaemia is stimulated by spinal analgesia and thiopentone anaesthesia, depressed by halothane and enflurane anaesthesia and unchanged during neuroleptanesthesia.	Enflurane	166-175	insulin	Canis lupus familiaris	28-35
6124186-0	1981	[Variations in blood prolactin in man during enflurane or Alfatesine anesthesias].	Enflurane	45-54	prolactin	Homo sapiens	21-30
6124186-2	1981	This finding led the authors to study variations in PRL during anaesthesia with Enflurane or Alfatesine.	Enflurane	80-89	prolactin	Homo sapiens	52-55
517782-3	1979	Analysis of enflurane standards ranging in concentration from 4.1 to 813 muM demonstrated linearity, with a correlation coefficient of 0.9999.	Enflurane	12-21	latexin	Homo sapiens	73-76
6779497-8	1980	When PaCO2 was lowered to 30 Torr, under 70% nitrous oxide + 1% enflurane, there was a 43% decrease in CBF (from a mean of 42 ml/100 G/min.	Enflurane	64-73	CCAAT enhancer binding protein zeta	Homo sapiens	103-106
6779497-16	1980	In conclusion, we believe that enflurane is a favorable anesthetic agent for neurosurgical operations at the concentration of 1%, CMRO2 is reduced, there is no significant effect on cerebral blood vessels, CBF and CVR do not change.	Enflurane	31-40	CCAAT enhancer binding protein zeta	Homo sapiens	206-209
517782-4	1979	As little as 8 muM enflurane may be detected in whole blood.	Enflurane	19-28	latexin	Homo sapiens	15-18
13202-1	1977	The effects of four commonly used halogenated anesthetic agents (methoxyflurane, halothane, enflurane and fluroxene) on rho-aminohippurate (PAH) uptake by rabbit renal cortical slices were examined.	Enflurane	92-101	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	140-143
43655-5	1979	During 2% enflurane, a small, and in two regions a significant decrease in rCBF was observed.	Enflurane	10-19	CCAAT/enhancer binding protein zeta	Rattus norvegicus	75-79
35043-2	1979	However, blood pressure decreases when an angiotensin II antagonist, saralasin, is administered during halothane or enflurane anesthesia, but not  during ketamine or fluroxene anesthesia.	Enflurane	116-125	angiotensinogen	Rattus norvegicus	42-56
728826-0	1978	Serum cholinesterase activity following enflurane anaesthesia.	Enflurane	40-49	butyrylcholinesterase	Homo sapiens	6-20
728826-1	1978	Serum cholinesterase activity was determined in 30 female patients anaesthetized with enflurane for excision of lump in the breast.	Enflurane	86-95	butyrylcholinesterase	Homo sapiens	6-20
1218143-2	1975	Exposure of Fischer 344 rats and Sprague-Dawley rats to 0.2% enflurane for 8 days resulted in enzyme induction as demonstrated by increasing serum inorganic fluoride and cytochrome P-450 concentrations.	Enflurane	61-70	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	170-186
973690-9	1976	In the absence of transient ischemia during occlusion (that is, rCBF greater than 18 ml/100 g/min), halothane and enflurane anesthesia were associated with significantly higher rCBF"s and lower stump pressures than was neuroleptanesthesia.	Enflurane	114-123	CCAAT/enhancer binding protein zeta	Rattus norvegicus	64-68
973690-9	1976	In the absence of transient ischemia during occlusion (that is, rCBF greater than 18 ml/100 g/min), halothane and enflurane anesthesia were associated with significantly higher rCBF"s and lower stump pressures than was neuroleptanesthesia.	Enflurane	114-123	CCAAT/enhancer binding protein zeta	Rattus norvegicus	177-181
973690-10	1976	Pre-occlusion and post-occlusion rCBF measurements also demonstrated cerebral vasodilation by halothane and enflurane (halothane greater than enflurane) and vasoconstriction by neuroleptanesthesia.	Enflurane	108-117	CCAAT/enhancer binding protein zeta	Rattus norvegicus	33-37
973690-10	1976	Pre-occlusion and post-occlusion rCBF measurements also demonstrated cerebral vasodilation by halothane and enflurane (halothane greater than enflurane) and vasoconstriction by neuroleptanesthesia.	Enflurane	142-151	CCAAT/enhancer binding protein zeta	Rattus norvegicus	33-37
184310-0	1976	[Effect of enflurane and surgical stress on plasma aldosterone and ACTH levels and renin activity].	Enflurane	11-20	proopiomelanocortin	Homo sapiens	67-71
1015228-0	1976	Impaired early insulin response to glycemic stimulus during enflurane anesthesia in dogs.	Enflurane	60-69	insulin	Canis lupus familiaris	15-22
33295171-4	2020	Results The retention time of sevoflurane and enflurane was similar to that of ethanol and tert butanol respectively when using the J&W DB-ALC1/DB-ALC2 gas chromatographic column, and interfered with the detection of ethanol content in blood; only J&W DB-ALC1 gas chromatographic column can separate the sevoflurane and ethanol components, so as to eliminate their influence on the detection of ethanol content in blood.	Enflurane	46-55	chromodomain helicase DNA binding protein 1 like	Homo sapiens	139-143
4672632-0	1972	[Effects of Ethrane, a new fluoride inhalation anesthetic, on carbohydrate and fat metabolism].	Enflurane	12-19	FAT atypical cadherin 1	Homo sapiens	79-82
5138493-0	1971	[An inhalation agent: ethrane-compound 347 (CFH2-o-CF2-CHFC1).	Enflurane	22-29	complement factor H	Homo sapiens	44-47
33295171-4	2020	Results The retention time of sevoflurane and enflurane was similar to that of ethanol and tert butanol respectively when using the J&W DB-ALC1/DB-ALC2 gas chromatographic column, and interfered with the detection of ethanol content in blood; only J&W DB-ALC1 gas chromatographic column can separate the sevoflurane and ethanol components, so as to eliminate their influence on the detection of ethanol content in blood.	Enflurane	46-55	chromodomain helicase DNA binding protein 1 like	Homo sapiens	255-259
25386744-10	2015	CYP2E1 mitochondrial activity was induced by acute Enflurane; while the activity of the microsomal protein was enhanced in alcoholised animals.	Enflurane	51-60	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-6
31545984-5	2019	Other volatile anesthetics, including isoflurane, enflurane, and halothane, induced IL-6 mRNA in fetal brains as well as sevoflurane, but propofol did not.	Enflurane	50-59	interleukin 6	Mus musculus	84-88
18689441-5	2008	Clinically relevant concentrations of isoflurane, sevoflurane, enflurane, and desflurane sensitize TRPV1 to capsaicin and protons and reduce the threshold for heat activation.	Enflurane	63-72	transient receptor potential cation channel subfamily V member 1	Homo sapiens	99-104
25593732-8	2014	Halothane, enflurane, isoflurane and desflurane are metabolized through the metabolic pathway involving cytochrome P-450 2E1 (CYP2E1) and produce trifluoroacetylated components; some of which may be immunogenic.	Enflurane	11-20	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	104-124
25593732-8	2014	Halothane, enflurane, isoflurane and desflurane are metabolized through the metabolic pathway involving cytochrome P-450 2E1 (CYP2E1) and produce trifluoroacetylated components; some of which may be immunogenic.	Enflurane	11-20	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	126-132
21913646-6	2011	Although the MP2 method slightly overestimates the blue shifts, the MP2 predicted frequency difference and the relative IR intensities of two nu(C-H) stretching bands for the enflurane-acetone complexes show good agreement with experiment.	Enflurane	175-184	tryptase pseudogene 1	Homo sapiens	13-16
21913646-6	2011	Although the MP2 method slightly overestimates the blue shifts, the MP2 predicted frequency difference and the relative IR intensities of two nu(C-H) stretching bands for the enflurane-acetone complexes show good agreement with experiment.	Enflurane	175-184	tryptase pseudogene 1	Homo sapiens	68-71
19225394-2	2009	We studied the effects of the major halogenated inhaled anesthetics (halothane, isoflurane, sevoflurane, enflurane, and desflurane) on Na(v)1.4, a well-characterized pharmacological model for Na(v) effects.	Enflurane	105-114	sodium voltage-gated channel alpha subunit 4	Rattus norvegicus	135-143
19442086-5	2009	CYP2E1 also plays a key role in the metabolism of isoflurane, sevoflurane, enflurane and desflurane.	Enflurane	75-84	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
21290074-1	2011	The structures and intermolecular interactions in the halogen bonded complexes of anaesthetics (chloroform, halothane, enflurane and isoflurane) with formaldehyde were studied by ab initio MP2 and CCSD(T) methods.	Enflurane	119-128	tryptase pseudogene 1	Homo sapiens	189-192
16309571-7	2005	ALA-S activity was induced by acute administration of anaesthetics (89%), veronal (240%) and ethanol (80%), while ALA-S mRNA expression augmented by chronic administration of enflurane, AIA and veronal.	Enflurane	175-184	aminolevulinic acid synthase 1	Mus musculus	114-119
17914793-2	2007	Theoretical studies are performed on enflurane (CHFCl-CF(2)-O-CHF(2)) to investigate the conformational properties and vibrational spectra.	Enflurane	37-46	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	62-67
17914793-16	2007	The dimer has an asymmetric cyclic structure, the two enflurane molecules being held together by two nonequivalent C-H...F hydrogen bonds, the C-H bond of the CHFCl group acting as a proton donor, and one of the F atoms of the CHF(2) groups acting as a proton acceptor.	Enflurane	54-63	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	227-232
17676386-10	2007	In kidney only mitochondrial cytochrome P-450 levels were modified by veronal; while in microsomes, only acute anaesthesia with Enflurane diminished cytochrome P-450 content.	Enflurane	128-137	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	149-165
16871063-0	2006	Dual actions of enflurane on postsynaptic currents abolished by the gamma-aminobutyric acid type A receptor beta3(N265M) point mutation.	Enflurane	16-25	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	108-113
16871063-4	2006	Furthermore, the role of the beta3 subunit in producing the depressant actions of enflurane on neocortical neurons was elucidated.	Enflurane	82-91	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	29-34
16871063-11	2006	CONCLUSION: At concentrations between MAC-awake and MAC-immobility, beta3-containing gamma-aminobutyric acid type A receptors contribute to the depressant actions of enflurane in the neocortex.	Enflurane	166-175	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	68-73
16871063-12	2006	The beta3(N265M) mutation affects both the prolonging and blocking effects of enflurane on gamma-aminobutyric acid type A receptor-mediated inhibitory postsynaptic currents in neocortical neurons.	Enflurane	78-87	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	4-9
15449957-2	2004	Binding to serum albumin is exothermic, yielding enthalpies (DeltaH(obs)) of -3 to -6 kcal/mol for BSA with a rank order of apparent equilibrium association constants (K(a) values): desflurane > isoflurane approximately enflurane > halothane >or= sevoflurane, with the differences being largely ascribed to entropic contributions.	Enflurane	223-232	albumin	Bos taurus	11-24
15644869-5	2005	Isoflurane had about the same potency in blocking Ca(v)3.3 and nRT currents, but enflurane, etomidate, propofol, and ethanol exhibited 2-4 fold higher potency in blocking nRT vs Ca(v)3.3 currents.	Enflurane	81-90	immunoglobulin lambda variable 7-46	Homo sapiens	178-186
14613517-3	2003	RESULTS: The beta2(N265M) mutation in M2 decreased the modulatory actions of propofol, etomidate and enflurane, but not of alphaxalone, while the direct actions of propofol, etomidate and alphaxalone were impaired.	Enflurane	101-110	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	13-18
14613517-4	2003	The beta2(M286W) mutation in M3 decreased the modulatory actions of propofol, etomidate and enflurane, but not of alphaxalone, whereas the direct action of propofol and etomidate, but not of alphaxalone, was impaired.	Enflurane	92-101	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	4-9
12198041-2	2002	Spastic (spA) mutants were slightly more sensitive (P = 0.02) to enflurane in the loss-of-righting reflex assay (50% effective concentration [EC(50)] = 1.17 +/- 0.06 atm for controls versus 0.97 +/- 0.06 atm for spA) but were also substantially more resistant (P = 0.01) to enflurane in the tail clamp assay (EC(50) = 1.96 +/- 0.10 atm for controls versus 2.58 +/- 0.25 atm for spA).	Enflurane	274-283	glycine receptor, beta subunit	Mus musculus	9-12
12502982-7	2003	RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1, but did not modify total protein secretion.	Enflurane	36-45	interleukin 6	Rattus norvegicus	149-162
12502982-7	2003	RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1, but did not modify total protein secretion.	Enflurane	36-45	C-X-C motif chemokine ligand 2	Rattus norvegicus	164-169
12502982-7	2003	RESULTS: Halothane, isoflurane, and enflurane (1 minimum alveolar concentration [MAC], 4 h) decreased rmIL-1beta-stimulated AT II cell secretions of interleukin-6, MIP-2, and MCP-1, but did not modify total protein secretion.	Enflurane	36-45	C-C motif chemokine ligand 2	Rattus norvegicus	175-180
12198041-2	2002	Spastic (spA) mutants were slightly more sensitive (P = 0.02) to enflurane in the loss-of-righting reflex assay (50% effective concentration [EC(50)] = 1.17 +/- 0.06 atm for controls versus 0.97 +/- 0.06 atm for spA) but were also substantially more resistant (P = 0.01) to enflurane in the tail clamp assay (EC(50) = 1.96 +/- 0.10 atm for controls versus 2.58 +/- 0.25 atm for spA).	Enflurane	65-74	glycine receptor, beta subunit	Mus musculus	0-7
12198041-2	2002	Spastic (spA) mutants were slightly more sensitive (P = 0.02) to enflurane in the loss-of-righting reflex assay (50% effective concentration [EC(50)] = 1.17 +/- 0.06 atm for controls versus 0.97 +/- 0.06 atm for spA) but were also substantially more resistant (P = 0.01) to enflurane in the tail clamp assay (EC(50) = 1.96 +/- 0.10 atm for controls versus 2.58 +/- 0.25 atm for spA).	Enflurane	65-74	glycine receptor, beta subunit	Mus musculus	9-12
12198041-2	2002	Spastic (spA) mutants were slightly more sensitive (P = 0.02) to enflurane in the loss-of-righting reflex assay (50% effective concentration [EC(50)] = 1.17 +/- 0.06 atm for controls versus 0.97 +/- 0.06 atm for spA) but were also substantially more resistant (P = 0.01) to enflurane in the tail clamp assay (EC(50) = 1.96 +/- 0.10 atm for controls versus 2.58 +/- 0.25 atm for spA).	Enflurane	274-283	glycine receptor, beta subunit	Mus musculus	0-7
11745669-3	2001	Nevertheless, we show here that exposure to the volatile general anesthetic (VGA) enflurane reveals a difference in neuromuscular performance between wild-type flies and those that carry a null allele in either the white or brown gene.	Enflurane	82-91	brown	Drosophila melanogaster	224-229
11772805-5	2002	We examined the effects of halothane, isoflurane, enflurane, diethyl ether, and ethanol on SP-induced currents mediated by SPR expressed in Xenopus oocytes, by using a whole-cell voltage clamp.	Enflurane	50-59	tachykinin precursor 1 S homeolog	Xenopus laevis	91-93
10794813-7	2000	The IC(50) values of the volatile anesthetics, halothane, sevoflurane, enflurane, and isoflurane for hIK1 inhibition were 0.69, 0.42, 1.01 and 1.03 mM, respectively, and were in the clinically used concentration range.	Enflurane	71-80	potassium calcium-activated channel subfamily N member 4	Homo sapiens	101-105
11605938-10	2001	IC50 values for inhibition of Kv1.1 channels were 2,800 and 5,200 microM, and Hill coefficients were 3.9 and 5.6 for enflurane and isoflurane, respectively.	Enflurane	117-126	potassium voltage-gated channel subfamily A member 1	Homo sapiens	30-35
11605938-14	2001	Kv1.1 channels would only be inhibited by enflurane at clinical concentrations (2% at 2 MAC and 8% at 3 MAC).	Enflurane	42-51	potassium voltage-gated channel subfamily A member 1	Homo sapiens	0-5
11465553-2	2001	Mice lacking the beta3 subunit of this receptor (beta3-/-) have a higher enflurane minimum alveolar concentration (MAC) than wild types (+/+).	Enflurane	73-82	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	17-58
10993774-2	2000	We therefore measured infarct size and p38, extracellular signal-regulated kinase (ERK), and c-Jun NH(2)-terminal kinase (JNK) MAPK phosphorylation (by biopsies) in enflurane-anesthetized pigs.	Enflurane	165-174	mitogen-activated protein kinase 8	Sus scrofa	122-125
11000668-17	2000	After administration of insulin, the activities of cyt P450 and defluorination of enflurane returned to baseline as the blood sugar level had been normalized.	Enflurane	82-91	insulin	Homo sapiens	24-31
10091716-1	1998	The aim of this study was to evaluate the effect of 5-, 15-, and 60-min enflurane anesthesia on the levels of Met-enkephalin, Leu-enkephalin and neuropeptide Y in discrete areas of the rabbit brain.	Enflurane	72-81	neuropeptide Y	Oryctolagus cuniculus	145-159
10754630-4	2000	METHODS: Nitrite release and iNOS expression were determined using the Griess reaction and Western and Northern blot techniques, respectively, in J774 murine macrophages stimulated with lipopolysaccharide and gamma-interferon in the absence and presence of various concentrations (0.25-2.0 minimum alveolar concentration [MAC]) of volatile anesthetics (i.e., halothane, enflurane, isoflurane, desflurane).	Enflurane	370-379	interferon gamma	Mus musculus	209-225
10611444-2	1999	At sub-anesthetic doses, halothane, isoflurane, enflurane and sevoflurane inhibit exchange of GTPgammaS for GDP bound to Galpha subunits and markedly enhance the dissociation of GTPgammaS, but fail to suppress GDPbetaS release.	Enflurane	48-57	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	121-127
10211019-7	1998	Peak CKR to the coronary venous effluent was attenuated by all anaesthetics (halothane group 156 (45), enflurane group 134 (20), sevoflurane group 132 (20), desflurane group 159 (25) iu litre-1; each P < 0.05).	Enflurane	103-112	choline kinase alpha	Rattus norvegicus	5-8
10091716-9	1998	In conclusion, enflurane affects the levels of Met, Leu-enkephalins and NPY in a manner depending on the duration of anesthesia and the brain structure.	Enflurane	15-24	neuropeptide Y	Oryctolagus cuniculus	72-75
9523823-9	1998	CONCLUSIONS: The beta3 subunit of the GABA(A) receptor appears to be important in the mediation of the immobilizing (tail clamp) but not obtunding (loss-of-righting reflex) effects of the volatile anesthetic agents enflurane and halothane.	Enflurane	215-224	gamma-aminobutyric acid (GABA) A receptor, subunit beta 3	Mus musculus	17-22
9495821-2	1998	Recent work has revealed that two specific amino acid residues within transmembrane domain (TM)2 and TM3 are necessary for positive modulation of GABAA and glycine receptors by the volatile anesthetic enflurane.	Enflurane	201-210	tropomyosin 3	Homo sapiens	101-104
8909983-4	1996	Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male.	Enflurane	0-9	aminolevulinic acid synthase 1	Mus musculus	44-49
9161752-6	1997	RESULTS: Enflurane added to the perfusate either upstream or downstream in relation to BAEC attenuated the relaxation induced by Bk at low concentrations.	Enflurane	9-18	kininogen 1	Homo sapiens	129-131
9161752-9	1997	CONCLUSION: Enflurane decreases the stability of EDRF/NO released after Bk stimulation while isoflurane can have opposite effects depending on whether the relaxation results from basal or Bk-stimulated release of endothelial derived relaxing factor(s).	Enflurane	12-21	alpha hemoglobin stabilizing protein	Homo sapiens	49-53
9161752-9	1997	CONCLUSION: Enflurane decreases the stability of EDRF/NO released after Bk stimulation while isoflurane can have opposite effects depending on whether the relaxation results from basal or Bk-stimulated release of endothelial derived relaxing factor(s).	Enflurane	12-21	kininogen 1	Homo sapiens	72-74
9161752-9	1997	CONCLUSION: Enflurane decreases the stability of EDRF/NO released after Bk stimulation while isoflurane can have opposite effects depending on whether the relaxation results from basal or Bk-stimulated release of endothelial derived relaxing factor(s).	Enflurane	12-21	kininogen 1	Homo sapiens	188-190
8916833-9	1996	CONCLUSIONS: Halothane and enflurane, but not isoflurane, inhibit bradykinin- and adenosine triphosphate-stimulated Ca2+ transients in endothelial cells.	Enflurane	27-36	kininogen 1	Bos taurus	66-76
8916833-6	1996	Although basal [Ca2+]i was unaltered by the anesthetics, both halothane and enflurane, in a dose-dependent manner, depressed the peak and plateau of the [Ca2+]i transient elicited by 10 nM bradykinin, whereas isoflurane had no effect.	Enflurane	76-85	kininogen 1	Bos taurus	189-199
8689955-0	1995	Stereoselective metabolism of enflurane by human liver cytochrome P450 2E1.	Enflurane	30-39	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	55-74
8741472-3	1996	We studied the depressant effects of halothane, isoflurane, enflurane, and sevoflurane on MSR amplitudes as a function of anesthetic concentration comparing with MAC value of each anesthetics.	Enflurane	60-69	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	90-93
8741472-8	1996	Concentration-response curves for MSR amplitudes were constructed and the concentrations which produced a half-maximum inhibition (IC50) were 0.56, 0.65, 0.97 and 1.18 mM for halothane, isoflurane, enflurane, and sevoflurane, respectively.	Enflurane	198-207	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	Rattus norvegicus	34-37
8786535-8	1996	As with F3, isoflurane, enflurane and halothane potentiated kainate-induced currents of GluR6 receptors.	Enflurane	24-33	glutamate receptor, ionotropic, kainate 2 S homeolog	Xenopus laevis	88-93
8823632-2	1996	Enflurane and sevoflurane have relatively similar saturated vapor pressures (SVPs 175 mmHg and 160 mmHg, respectively, at 20 degrees C) and potencies (MACs 1.68% and 2%, respectively).	Enflurane	0-9	acyl-CoA synthetase medium chain family member 1	Homo sapiens	151-157
8672327-0	1995	Effects of halothane, enflurane and isoflurane on contraction of rat aorta induced by endothelin-1.	Enflurane	22-31	endothelin 1	Rattus norvegicus	86-98
8672327-2	1995	These studies were performed to see if halothane, enflurane and isoflurane attenuate endothelin-1-evoked contraction and if they interact with endothelium-dependent or -independent vasoactive substances.	Enflurane	50-59	endothelin 1	Rattus norvegicus	85-97
8672327-7	1995	Isoflurane at 1 and 2 MAC concentration, and enflurane at 2 MAC, induced a rightward shift of the dose-response curve obtained with endothelin-1 in both endothelium denuded and intact rings, associated with a decrease in maximal tension generated in the latter rings.	Enflurane	45-54	endothelin 1	Rattus norvegicus	132-144
8672327-10	1995	The present study indicates that isoflurane at 1 and 2 MAC, and enflurane at 2 MAC, significantly decreased endothelin-1-induced contraction of isolated rat aorta.	Enflurane	64-73	endothelin 1	Rattus norvegicus	108-120
8689955-3	1995	Human liver enflurane metabolism to difluoromethoxydifluoroacetic acid (DFMDFA) and inorganic fluoride is catalyzed in vivo and in vitro by cytochrome P450 2E1.	Enflurane	12-21	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	140-159
8689955-4	1995	The purpose of this investigation was to characterize enflurane racemate and enantiomer metabolism to test the hypothesis that fluorinated ether anesthetic metabolism by cytochrome P450 2E1 exhibits substrate stereoselectivity.	Enflurane	54-63	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	170-189
8162670-0	1994	Clinical enflurane metabolism by cytochrome P450 2E1.	Enflurane	9-18	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	33-52
7793203-5	1995	In the enflurane group, B cells (Leu12+), total T cells (Leu4+), inducer T cells (CD4+, Leu8+) and the CD4/CD8 ratio decreased and suppressor T cells (CD8+, Leu15+) increased significantly after skin incision.	Enflurane	7-16	CD4 molecule	Homo sapiens	82-85
7793203-5	1995	In the enflurane group, B cells (Leu12+), total T cells (Leu4+), inducer T cells (CD4+, Leu8+) and the CD4/CD8 ratio decreased and suppressor T cells (CD8+, Leu15+) increased significantly after skin incision.	Enflurane	7-16	CD4 molecule	Homo sapiens	103-106
7793203-5	1995	In the enflurane group, B cells (Leu12+), total T cells (Leu4+), inducer T cells (CD4+, Leu8+) and the CD4/CD8 ratio decreased and suppressor T cells (CD8+, Leu15+) increased significantly after skin incision.	Enflurane	7-16	CD8a molecule	Homo sapiens	107-110
7793203-5	1995	In the enflurane group, B cells (Leu12+), total T cells (Leu4+), inducer T cells (CD4+, Leu8+) and the CD4/CD8 ratio decreased and suppressor T cells (CD8+, Leu15+) increased significantly after skin incision.	Enflurane	7-16	CD8a molecule	Homo sapiens	151-154
7875542-4	1994	Liver and kidney delta-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane.	Enflurane	128-137	5'-aminolevulinate synthase 1	Homo sapiens	17-53
7875542-4	1994	Liver and kidney delta-Aminolevulinic acid synthetase (ALA-S) activities were 85% (P < 0.01) induced after the third dose of Enflurane, instead induction of this enzyme was only detected, in animals receiving one dose of Isoflurane.	Enflurane	128-137	5'-aminolevulinate synthase 1	Homo sapiens	55-60
8541440-1	1995	AIM: The study investigates the influence of enflurane (EN) on macroscopic currents of the nicotinic acetylcholinergic receptor channel (nAChR).	Enflurane	45-54	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	137-142
7860779-7	1994	Enflurane alone induced c-fos expression in the same brain area; however, the number of Fos-positive cells and double-labeled cells were decreased two- to fivefold and three- to eightfold, respectively, compared with the abdominal surgery groups.	Enflurane	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	24-29
8198912-0	1994	Choline acetyltransferase activity of rat synaptosomes is sensitive to enflurane, but not halothane or isoflurane.	Enflurane	71-80	choline O-acetyltransferase	Rattus norvegicus	0-25
8198912-1	1994	We have examined the activity of choline acetyltransferase (ChAT) in rat cortical synaptosomes in the presence of three volatile anaesthetic agents: enflurane, halothane and isoflurane.	Enflurane	149-158	choline O-acetyltransferase	Rattus norvegicus	33-58
8162670-2	1994	Metabolism of the volatile anesthetic enflurane to inorganic fluoride ion by human liver microsomes in vitro is catalyzed predominantly by the cytochrome P450 isoform CYP2E1.	Enflurane	38-47	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	167-173
7681105-3	1993	Potentiation of GABA-activated currents by enflurane was dependent on the composition of GABAA receptor protein subunits; the order of sensitivity was alpha 1 beta 1 > alpha 1 beta 1 gamma 2S = alpha 1 beta 1 gamma 2L > total mRNA.	Enflurane	43-52	GABA(A) receptor-associated protein L homeolog	Xenopus laevis	89-94
8141457-2	1994	METHODS: We determined the effect of halothane, enflurane, and isoflurane on the binding of the Ca2+ channel blocker PN200-110 to skeletal muscle membranes isolated from malignant hyperthermia-susceptible and normal pigs.	Enflurane	48-57	carbonic anhydrase 2	Sus scrofa	96-99
8214671-5	1993	Isoniazid-treated, enflurane anesthetized rats developed a 31% reduction in maximal urinary concentrating ability and a 3.5-fold increase in excretion of N-acetyl-beta-glucosaminidase.	Enflurane	19-28	O-GlcNAcase	Rattus norvegicus	154-183
8289749-3	1993	Halothane did so most profoundly, resulting in a maximum slowing of 40 beats-1 compared with a maximum slowing of about 20 beats min-1 with both isoflurane and enflurane.	Enflurane	160-169	CD59 molecule (CD59 blood group)	Homo sapiens	129-134
8515538-4	1993	Components N17, P23, N31, and P50, thought to be specific SEP responses, showed a dose-dependent increase in latencies under enflurane while P12, the initial SEP components, did not show any significant changes throughout the experiment.	Enflurane	125-134	prostaglandin E synthase 3	Homo sapiens	16-19
8515538-4	1993	Components N17, P23, N31, and P50, thought to be specific SEP responses, showed a dose-dependent increase in latencies under enflurane while P12, the initial SEP components, did not show any significant changes throughout the experiment.	Enflurane	125-134	nuclear factor kappa B subunit 1	Homo sapiens	30-33
8515538-7	1993	However, the peak-to-peak amplitude between P23 and N31 was enhanced dose-dependently with enflurane up to 1.5 MAC.	Enflurane	91-100	prostaglandin E synthase 3	Homo sapiens	44-47
1534467-3	1992	The mean enflurane uptake rates were between 24 and 14 ml.70kg-1.min-1 between 10 and 60 minutes.	Enflurane	9-18	CD59 molecule (CD59 blood group)	Homo sapiens	65-70
8392355-1	1993	The visual pigment rhodopsin was used as an intrinsic probe to measure the effect of incorporation of enflurane into bovine rod outer segment disk membranes.	Enflurane	102-111	rhodopsin	Bos taurus	19-28
8392355-2	1993	At moderately low enflurane concentration, we find that, while extrinsic probes show little membrane perturbation, rhodopsin may experience large changes with respect to the native lipid-protein interactions which modulate some of its properties.	Enflurane	18-27	rhodopsin	Bos taurus	115-124
8392355-4	1993	As a function of enflurane concentration, there appears to be an increasing population of rhodopsin molecules for which the metarhodopsin I-->II transition is blocked, while it is accelerated in the remaining population.	Enflurane	17-26	rhodopsin	Bos taurus	90-99
8392355-6	1993	These results are all consistent with a reduction of the membrane order accompanied by lateral aggregation of rhodopsin in the presence of enflurane.	Enflurane	139-148	rhodopsin	Bos taurus	110-119
8392355-7	1993	By comparison with the perturbation probed by a spin label, the large molecular environment change experienced by the rhodopsin molecule suggests that enflurane may concentrate at the lipid-protein interface.	Enflurane	151-160	rhodopsin	Bos taurus	118-127
8433499-3	1993	Enflurane 0.6 and 1.2MAC prolonged PEP, and shortened 1/PEP2 and Pd/ICT significantly.	Enflurane	0-9	prolyl endopeptidase	Homo sapiens	35-38
1942510-9	1991	In the enflurane group, postoperative S-GPT levels were significantly higher, but those of the FK group were not.	Enflurane	7-16	glutamic--pyruvic transaminase	Homo sapiens	40-43
1942510-10	1991	S-GPT on 2nd to 4th postoperative days of the enflurane group were significantly higher than those of the FK group.	Enflurane	46-55	glutamic--pyruvic transaminase	Homo sapiens	2-5
15278623-4	1991	In each age group, the incidence of opisthotonus occurred in the following order: sevoflurane > isoflurane > enflurane > methoxyflurane > halothane.	Enflurane	115-124	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	36-48
1906529-7	1991	The SARA system showed substantial CO2 readings when no CO2 was present (5 mm Hg per dose/L) and displayed small enflurane readings (0.1% per dose/L) when no enflurane was present.	Enflurane	113-122	zinc finger FYVE-type containing 9	Homo sapiens	4-8
1656112-0	1991	[The effect of enflurane anesthesia on plasma superoxide dismutase (SOD)-like activity in elderly patients].	Enflurane	15-24	superoxide dismutase 1	Homo sapiens	46-66
1656112-0	1991	[The effect of enflurane anesthesia on plasma superoxide dismutase (SOD)-like activity in elderly patients].	Enflurane	15-24	superoxide dismutase 1	Homo sapiens	68-71
1656112-1	1991	Plasma SOD-like activity during enflurane anesthesia was measured according to electron spin resonance in ten elderly patients over 66 years and in nine patients under 64 years.	Enflurane	32-41	superoxide dismutase 1	Homo sapiens	7-10
1651894-5	1991	In contrast, ACTH and cortisol rose to higher levels in enflurane treated patients.	Enflurane	56-65	proopiomelanocortin	Homo sapiens	13-17
1906529-7	1991	The SARA system showed substantial CO2 readings when no CO2 was present (5 mm Hg per dose/L) and displayed small enflurane readings (0.1% per dose/L) when no enflurane was present.	Enflurane	158-167	zinc finger FYVE-type containing 9	Homo sapiens	4-8
1986663-2	1991	The current study compared the effects of halothane, enflurane, and isoflurane on resting membrane potential and conductance of hippocampal CA1 neurons in vitro.	Enflurane	53-62	carbonic anhydrase 1	Homo sapiens	140-143
2048706-12	1991	With the respective inhalational agents, Rin increased maximally between 3% (halothane) or 8% (enflurane) and 21% (isoflurane), Rex between 16% (halothane, enflurane) and 29% (isoflurane).	Enflurane	95-104	Ras like without CAAX 2	Homo sapiens	41-44
2048706-12	1991	With the respective inhalational agents, Rin increased maximally between 3% (halothane) or 8% (enflurane) and 21% (isoflurane), Rex between 16% (halothane, enflurane) and 29% (isoflurane).	Enflurane	156-165	Ras like without CAAX 2	Homo sapiens	41-44
2306457-5	1990	At a 2:1 lipid/anesthetic mole ratio, the polar anesthetics, halothane and enflurane, increased the ratio of (P = O stretching band area)/((CH3)3-N+ stretching band area) by 26.3% and 21.1%, respectively, whereas apolar CCl4 increased it 10.5%.	Enflurane	75-84	C-C motif chemokine ligand 4	Homo sapiens	220-224
2393109-5	1990	However, mean surface PO2 of liver and small intestine decreased to similar degrees (20%) during isoflurane and enflurane.	Enflurane	112-121	PO2	Sus scrofa	22-25