PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
6877243-9	1983	Chondroitin sulfate was similar to heparin in its effects upon the CRP-poly-L-arginine (PLA) interaction, while hyaluronic acid enhanced CRP-PLA precipitation at all concentrations tested and DNA had neither augmenting nor solubilizing effects.	polyarginine	71-86	C-reactive protein	Homo sapiens	67-70
6313150-5	1983	Polycations such as poly-L-arginine and histone competitively inhibited the action of ACTH, supporting the view that the affinity of ACTH for the adenylate cyclase system is determined by the basic core of amino acids at residues 15-18.	polyarginine	20-35	pro-opiomelanocortin-alpha	Mus musculus	86-90
6313150-5	1983	Polycations such as poly-L-arginine and histone competitively inhibited the action of ACTH, supporting the view that the affinity of ACTH for the adenylate cyclase system is determined by the basic core of amino acids at residues 15-18.	polyarginine	20-35	pro-opiomelanocortin-alpha	Mus musculus	133-137
6158341-6	1980	The action of poly(arginine) is inhibited by pretreatment of basophils at 47 degrees C or with neuraminidase.	polyarginine	14-28	neuraminidase 1	Homo sapiens	95-108
7214367-5	1981	The histone H3 fraction, poly-L-lysine and poly-L-arginine, inhibited induction of differentiation of M1 cells.	polyarginine	43-58	H3 clustered histone 7	Mus musculus	4-14
32506916-3	2020	In this study, we developed cisplatin-loaded polyarginine-hyaluronic acid nanoscale particles (Cis-pARG-HA NPs) with high colloidal stability, marked drug loading efficiency, unimpaired biological activity and tumor targeting ability.	polyarginine	45-57	poly(ADP-ribose) glycohydrolase	Homo sapiens	99-103
33115824-5	2021	All four CaSR NAMs inhibited poly-L-arginine-induced AHR in naive mice, and suppressed both AHR and airways inflammation in a murine surrogate of acute asthma, confirming class specificity.	polyarginine	29-44	calcium-sensing receptor	Mus musculus	9-13
32450093-4	2020	The polyarginine moiety of affibody sealed methotrexate (MTX)-loaded MUA-Au NCs through charge effect, as well as leaving the rest targeting fragment of the affibody to specifically bind tumor overexpressed EGFR.	polyarginine	4-16	epidermal growth factor receptor	Homo sapiens	207-211
30988787-6	2019	Furthermore, poly-arginine R18 treatment promoted neurocyte cell growth, reduced apoptosis, induced the protein expression of LC3 and Beclin-1, and suppressed p62 expression by promoting autophagy in vitro.	polyarginine	13-26	annexin A3	Rattus norvegicus	126-129
32856018-1	2020	Background: Electrostatic complexes of poly (l-Arginine) (pArg) and hyaluronic acid (HA) have been investigated for their functional applications to supply free or polymeric form of l-Arginine (Arg) to target cells.	polyarginine	39-56	poly(ADP-ribose) glycohydrolase	Homo sapiens	58-62
32856018-4	2020	We showed that polyarginine-hyaluronic acid ionic nanocomplexes (pArg-HA iNCs) could be an effective way to deliver Arg to target cell populations.	polyarginine	15-27	poly(ADP-ribose) glycohydrolase	Homo sapiens	65-69
32120161-9	2020	The bioconjugate 21 containing the Co complex 4 and the combined phenylalanine and polyarginine cell penetrating sequence P3 shows better activity against the liver cancer line HepG2 than the parent Co(III) complex 4.	polyarginine	83-95	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	199-206
31212607-1	2019	The purpose of this study was to develop an oral proliposomal powder of protein using poly-l-arginine-conjugated 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPE-PEG) (PLD) for enhancing cellular association upon reconstitution and to compare its effects with a non-grafted and PEGylated formulation.	polyarginine	86-101	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	195-198
30914800-6	2019	We thus generated a derivative of TIS11b called R9-ZnCS334D, by combining N-terminal domain deletion, serine-to-aspartate substitution at position 334 to enhance the function of the protein and fusion to the cell-penetrating peptide polyarginine R9.	polyarginine	233-245	ZFP36 ring finger protein like 1	Homo sapiens	34-40
30988787-6	2019	Furthermore, poly-arginine R18 treatment promoted neurocyte cell growth, reduced apoptosis, induced the protein expression of LC3 and Beclin-1, and suppressed p62 expression by promoting autophagy in vitro.	polyarginine	13-26	beclin 1	Rattus norvegicus	134-142
30988787-6	2019	Furthermore, poly-arginine R18 treatment promoted neurocyte cell growth, reduced apoptosis, induced the protein expression of LC3 and Beclin-1, and suppressed p62 expression by promoting autophagy in vitro.	polyarginine	13-26	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	159-162
30271146-5	2018	Methods: Polyarginine was coupled with the polyethylene glycol (PEG) chain and the cNGR moiety, yielding a cNGR-tiR9-PEG2,000-distearoylphosphatidylethanolamine conjugate.	polyarginine	9-21	insulin-like growth factor 2	Mus musculus	117-121
30048621-3	2018	Attachment of poly-arginine to this peptide (R9-SOCS1-KIR) allows it to penetrate the plasma membrane in aqueous media.	polyarginine	14-27	suppressor of cytokine signaling 1	Homo sapiens	48-53
30048621-3	2018	Attachment of poly-arginine to this peptide (R9-SOCS1-KIR) allows it to penetrate the plasma membrane in aqueous media.	polyarginine	14-27	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	54-57
31058187-3	2019	Poly-L-Arginine (PLA) is a kind of synthetic cationic polypeptides, which is widely used to mimic the effects of MBP on epithelial cells in vitro.	polyarginine	0-15	myelin basic protein	Homo sapiens	113-116
31058187-3	2019	Poly-L-Arginine (PLA) is a kind of synthetic cationic polypeptides, which is widely used to mimic the effects of MBP on epithelial cells in vitro.	polyarginine	17-20	myelin basic protein	Homo sapiens	113-116
30319254-7	2018	Treating cancer cells with GO-PEG-(P-l-Arg)/miR-101 and incorporating near infrared laser irradiation induced 68% apoptosis and suppressed Stathmin1 protein.	polyarginine	34-42	stathmin 1	Homo sapiens	139-148
30023598-0	2017	Intracellular Delivery of beta-Galactosidase Enzyme Using Arginase-Responsive Dextran Sulfate/Poly-l-arginine Capsule for Lysosomal Storage Disorder.	polyarginine	94-109	galactosidase, beta 1	Mus musculus	26-44
28355889-1	2018	We constructed a dual ligands-modified nanostructured lipid carrier (NLC) called PAR-NLC, in which the epidermal growth factor receptor (EGFR)-targeted small peptide AEYLR was attached to the distal end of PEG2000 anchored on the NLC surface naming PEG-AEYLR, and poly-arginine (R8) as a classic cell-penetrating peptide was attached directly to the NLC surface.	polyarginine	264-277	epidermal growth factor receptor	Mus musculus	103-135
28355889-1	2018	We constructed a dual ligands-modified nanostructured lipid carrier (NLC) called PAR-NLC, in which the epidermal growth factor receptor (EGFR)-targeted small peptide AEYLR was attached to the distal end of PEG2000 anchored on the NLC surface naming PEG-AEYLR, and poly-arginine (R8) as a classic cell-penetrating peptide was attached directly to the NLC surface.	polyarginine	264-277	epidermal growth factor receptor	Mus musculus	137-141
29658165-1	2018	This study reports on the electropolymerization of a low toxic and biocompatible nanopolymer with entitle poly arginine-graphene quantum dots-chitosan (PARG-GQDs-CS) as a novel strategy for surface modification of glassy carbon surface and preparation of a new interface for measurement of malondialdehyde (MDA) in exhaled breath condensate.	polyarginine	106-119	poly(ADP-ribose) glycohydrolase	Homo sapiens	152-156
30013990-0	2018	Poly-L-Arginine Induces Apoptosis of NCI-H292 Cells via ERK1/2 Signaling Pathway.	polyarginine	0-15	mitogen-activated protein kinase 3	Homo sapiens	56-62
29789497-9	2018	Recent studies using polyarginine analogues and designer peptides for inhibiting p53 aggregation and tumor growth gives further encouragement in treating cancer as a protein aggregation disease.	polyarginine	21-33	tumor protein p53	Homo sapiens	81-84
28986203-16	2018	Pre-clinical studies demonstrated that the basic proteins lactoferrin, platelet factor-4 (PF-4), IL-8 and polyarginine, as a model of the eosinophil cationic protein (ECP), found in COPD sputum neutralise the anticoagulant activity of heparin.	polyarginine	106-118	ribonuclease A family member 3	Homo sapiens	138-165
27761921-8	2016	RESULTS: RAN translation from CCG repeats is supported in all 3 potential reading frames, generating polyproline, polyarginine, and polyalanine proteins, respectively.	polyarginine	114-126	RAN, member RAS oncogene family	Homo sapiens	9-12
28536076-0	2017	Polyarginine and its analogues inhibit p53 mutant aggregation and cancer cell proliferation in vitro.	polyarginine	0-12	tumor protein p53	Homo sapiens	39-42
28536076-6	2017	Here in this study we focus on the inhibitory effects of polyarginine and its analogues polyornithine, canavanine, and citrulline on the inhibition of p53 mutant peptide aggregation, and p53 mutant cancer cell proliferation inhibition in vitro.	polyarginine	57-69	tumor protein p53	Homo sapiens	151-154
28536076-6	2017	Here in this study we focus on the inhibitory effects of polyarginine and its analogues polyornithine, canavanine, and citrulline on the inhibition of p53 mutant peptide aggregation, and p53 mutant cancer cell proliferation inhibition in vitro.	polyarginine	57-69	tumor protein p53	Homo sapiens	187-190
28536076-8	2017	The results show that polyarginine, and polyornithine, in micromolar concentrations, significantly inhibits p53 conserved peptide aggregation, and the cell proliferation of p53 mutant cancer cells.	polyarginine	22-34	tumor protein p53	Homo sapiens	108-111
28536076-8	2017	The results show that polyarginine, and polyornithine, in micromolar concentrations, significantly inhibits p53 conserved peptide aggregation, and the cell proliferation of p53 mutant cancer cells.	polyarginine	22-34	tumor protein p53	Homo sapiens	173-176
28415460-1	2017	This study reports on the electropolymerization of a low toxic and biocompatible polymer with entitle poly arginine-graphene quantum dots (PARG-GQDs) as a novel strategy for surface modification of glassy carbon (GC) surface and preparation a new interface for biomedical application.	polyarginine	102-115	poly(ADP-ribose) glycohydrolase	Homo sapiens	139-143
28487936-0	2017	Protein therapy using MafA fused to a polyarginine transduction domain attenuates glucose levels of streptozotocin-induced diabetic mice.	polyarginine	38-50	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian)	Mus musculus	22-26
28456996-0	2017	Tau peptides and tau mutant protein aggregation inhibition by cationic polyethyleneimine and polyarginine.	polyarginine	93-105	microtubule associated protein tau	Homo sapiens	0-3
28456996-0	2017	Tau peptides and tau mutant protein aggregation inhibition by cationic polyethyleneimine and polyarginine.	polyarginine	93-105	microtubule associated protein tau	Homo sapiens	17-20
28824209-5	2017	Activation of the polyarginine (CR7) was achieved in situ during cleavage of protected peptide (C(Trt)R(Pbf)7) from the Rink amide resin using 5 equiv.	polyarginine	18-30	teratocarcinoma-derived growth factor 1 pseudogene 7	Homo sapiens	32-35
28794328-2	2017	In this paper, by preparing poly(L-arginine) modified glassy carbon electrode (P-L-Arg/GCE) with a simple method, a highly sensitive electrochemical sensor for simultaneously detecting HQ, CC and RS was constructed successfully due to the large surface area, good electronic properties and catalytic ability of P-L-Arg/GCE and the electrostatic action between P-L-Arg (positive) and targets (negative).	polyarginine	28-44	glycine decarboxylase	Homo sapiens	79-90
28794328-2	2017	In this paper, by preparing poly(L-arginine) modified glassy carbon electrode (P-L-Arg/GCE) with a simple method, a highly sensitive electrochemical sensor for simultaneously detecting HQ, CC and RS was constructed successfully due to the large surface area, good electronic properties and catalytic ability of P-L-Arg/GCE and the electrostatic action between P-L-Arg (positive) and targets (negative).	polyarginine	28-44	glycine decarboxylase	Homo sapiens	311-322
27390612-3	2016	Herein, we designed a chimeric p53 protein flanked with the MyoD N-terminal transcriptional activation domain (amino acids 1-62, called M3) and a poly-arginine (R12) cell penetrating signal in its N-and C-termini respectively.	polyarginine	146-159	tumor protein p53	Homo sapiens	31-34
28025997-6	2016	Of note, the polyarginine-mediated internalization of Chk1-NP redistributed nuclear Chk1 with a prominent decrease in the nucleus in the absence of DNA damage.	polyarginine	13-25	checkpoint kinase 1	Homo sapiens	54-58
28025997-6	2016	Of note, the polyarginine-mediated internalization of Chk1-NP redistributed nuclear Chk1 with a prominent decrease in the nucleus in the absence of DNA damage.	polyarginine	13-25	checkpoint kinase 1	Homo sapiens	84-88
27381066-0	2016	Span poly-L-arginine nanoparticles are efficient non-viral vectors for PRPF31 gene delivery: An approach of gene therapy to treat retinitis pigmentosa.	polyarginine	5-20	pre-mRNA processing factor 31	Mus musculus	71-77
27381066-7	2016	Span-polyarginine (SP-PA) nanoparticles were able to efficiently transfect the GFP and PRPF31 plasmid in mice retinas.	polyarginine	5-17	pre-mRNA processing factor 31	Mus musculus	87-93
27664712-3	2016	expand the mutation spectrum for ichthyosis with confetti caused by mutations in KRT1, showing that a polyarginine frameshift in the keratin-1 tail can also cause this disorder.	polyarginine	102-114	keratin 1	Homo sapiens	81-85
27664712-3	2016	expand the mutation spectrum for ichthyosis with confetti caused by mutations in KRT1, showing that a polyarginine frameshift in the keratin-1 tail can also cause this disorder.	polyarginine	102-114	keratin 1	Homo sapiens	133-142
28584879-6	2016	We demonstrated that poly(glutamic acid) and poly(arginine) associated with the IGF-1 via electrostatic interactions, forming a net charged nanoscale polyelectrolyte complex (nanoplex).	polyarginine	45-59	insulin-like growth factor 1	Rattus norvegicus	80-85
27317619-5	2016	Based on the information of this prototype peptide, here we generated the more powerful anti-tumor peptide "r9-CatB-p14 MIS," which comprises the minimal inhibitory sequence of the mitochondrial targeting p14(ARF) protein in combination with the proteolytic cleavage site for cathepsin B, which is activated in various tumor cells, fused with the nine-polyarginine-domain for cell penetration, and demonstrated its novel action of regulating mitochondrial function in accordance with localization of endogenous p14(ARF) .	polyarginine	352-364	cyclin dependent kinase inhibitor 2A	Homo sapiens	116-119
27317619-5	2016	Based on the information of this prototype peptide, here we generated the more powerful anti-tumor peptide "r9-CatB-p14 MIS," which comprises the minimal inhibitory sequence of the mitochondrial targeting p14(ARF) protein in combination with the proteolytic cleavage site for cathepsin B, which is activated in various tumor cells, fused with the nine-polyarginine-domain for cell penetration, and demonstrated its novel action of regulating mitochondrial function in accordance with localization of endogenous p14(ARF) .	polyarginine	352-364	anti-Mullerian hormone	Homo sapiens	120-123
27317619-5	2016	Based on the information of this prototype peptide, here we generated the more powerful anti-tumor peptide "r9-CatB-p14 MIS," which comprises the minimal inhibitory sequence of the mitochondrial targeting p14(ARF) protein in combination with the proteolytic cleavage site for cathepsin B, which is activated in various tumor cells, fused with the nine-polyarginine-domain for cell penetration, and demonstrated its novel action of regulating mitochondrial function in accordance with localization of endogenous p14(ARF) .	polyarginine	352-364	cathepsin B	Homo sapiens	111-115
26452883-3	2015	A reasonable reaction mechanism of tectoridin on the poly(L-Arginine)/GCE was also dicussed and proposed, which could be a reference for the pharmacological action of tectoridin in clinical study.	polyarginine	53-69	aminomethyltransferase	Homo sapiens	70-73
26462022-5	2015	Herein, we report that the cell penetrating peptide (polyarginine, R11)-conjugated p53C can exhibit a preferential uptake and growth inhibit of UCB cells expressing either mutant or wild-type TP53 by the activation of p53-dependent pathway.	polyarginine	53-65	tumor protein p53	Homo sapiens	192-196
26462022-5	2015	Herein, we report that the cell penetrating peptide (polyarginine, R11)-conjugated p53C can exhibit a preferential uptake and growth inhibit of UCB cells expressing either mutant or wild-type TP53 by the activation of p53-dependent pathway.	polyarginine	53-65	tumor protein p53	Homo sapiens	83-86
28116315-0	2016	LPS Cooperates with Poly-L-Arginine to Promote IL-6 and IL-8 Release via the JNK Signaling Pathway in NCI-H292 Cells.	polyarginine	20-35	interleukin 6	Homo sapiens	47-51
28116315-0	2016	LPS Cooperates with Poly-L-Arginine to Promote IL-6 and IL-8 Release via the JNK Signaling Pathway in NCI-H292 Cells.	polyarginine	20-35	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
28116315-0	2016	LPS Cooperates with Poly-L-Arginine to Promote IL-6 and IL-8 Release via the JNK Signaling Pathway in NCI-H292 Cells.	polyarginine	20-35	mitogen-activated protein kinase 8	Homo sapiens	77-80
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	48-63	interleukin 6	Homo sapiens	141-154
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	48-63	interleukin 6	Homo sapiens	156-160
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	48-63	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	65-68	interleukin 6	Homo sapiens	141-154
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	65-68	interleukin 6	Homo sapiens	156-160
28116315-2	2016	Herein, we aimed to study the mechanism whereby poly-L-arginine (PLA) and lipopolysaccharide (LPS) can synergistically induce the release of interleukin-6 (IL-6) and IL-8 in NCI-H292 cells.	polyarginine	65-68	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
26395266-2	2015	The surface of the particles is then decorated, using electrostatic interactions, with a polyarginine-peptide nucleic acid (R8-PNA) conjugate targeting the miR221 microRNA.	polyarginine	89-101	microRNA 221	Homo sapiens	156-162
24631228-3	2014	OBJECTIVE: We used the mouse skin frostbite model to evaluate the effect of poly-l-arginine contained in lotion (PAL) applied topically to involved skin.	polyarginine	76-91	Shc SH2-domain binding protein 1	Mus musculus	113-116
25462345-1	2015	We previously identified the NS5A/HSP70 binding site to be a hairpin moiety at C-terminus of NS5A domain I and showed a corresponding cyclized polyarginine-tagged synthetic peptide (HCV4) significantly blocks virus production.	polyarginine	143-155	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
26100636-7	2015	Although neuroprotection was partially dependent upon CN2097 binding to the PDZ domain of PSD-95, our results show that the polyarginine-rich transport moiety C-R(7), linked to the PDZ-PSD-95-binding cyclic peptide, was sufficient to mediate short and long term protection via a mitochondrial targeting mechanism.	polyarginine	124-136	discs large MAGUK scaffold protein 4	Homo sapiens	185-191
25416477-8	2015	In vitro experiments showed that polyarginine enhanced the cytotoxicity of bCD, and R9-bCDmut had a stronger cytotoxicity than R9-bCD proteins.	polyarginine	33-45	cytochrome P450 family 4 subfamily V member 2	Homo sapiens	75-78
25000413-9	2014	We lastly found that PKD was predominantly activated by poly-L-arginine, lysophosphatidic acid and thrombin in human lung epithelial cells and that PKD promoted epithelial barrier dysfunction.	polyarginine	56-71	protein kinase D1	Homo sapiens	21-24
24323884-0	2014	Polyarginine induces an antitumor immune response through binding to toll-like receptor 4.	polyarginine	0-12	toll like receptor 4	Homo sapiens	69-89
24510544-3	2014	Here we investigate the feasibility of encapsulating SPARC-siRNA in the bilayers of layer-by-layer (LbL) nanoparticles (NPs) with poly(L-arginine) (ARG) and dextran (DXS) as polyelectrolytes.	polyarginine	130-146	secreted protein acidic and cysteine rich	Homo sapiens	53-58
24510544-3	2014	Here we investigate the feasibility of encapsulating SPARC-siRNA in the bilayers of layer-by-layer (LbL) nanoparticles (NPs) with poly(L-arginine) (ARG) and dextran (DXS) as polyelectrolytes.	polyarginine	148-151	secreted protein acidic and cysteine rich	Homo sapiens	53-58
24323884-2	2014	Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation.	polyarginine	93-105	toll like receptor 4	Homo sapiens	132-152
24323884-2	2014	Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation.	polyarginine	93-105	toll like receptor 4	Homo sapiens	154-158
22641696-4	2012	In the sequence upstream of the initiation site of Orai1beta, there is a poly-arginine sequence previously suggested to be involved in interaction of Orai1 with plasma membrane phosphatidylinositol-4,5-bisphosphate.	polyarginine	73-86	ORAI calcium release-activated calcium modulator 1	Homo sapiens	51-56
24409521-4	2013	The S/O nanoparticles consisted of OVA and hydrophobic surfactant molecules and were dispersed in oil; enhanced induction of antigen-specific antibody was observed after the addition of polyarginine (R6) into the same S/O nanoparticle containing OVA.	polyarginine	186-198	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	246-249
23352910-2	2013	In this work, we investigated the potential of novel bi-ligand (transferrin-poly-l-arginine) liposomal vector for delivery of desired gene to brain, in vivo.	polyarginine	76-91	transferrin	Rattus norvegicus	64-75
23269116-8	2013	HEK-CaSR stimulation with PA or Ca(2+) resulted in greater pERK activation than that of stimulated HEK-WT cells.	polyarginine	26-28	calcium sensing receptor	Homo sapiens	4-8
23269116-8	2013	HEK-CaSR stimulation with PA or Ca(2+) resulted in greater pERK activation than that of stimulated HEK-WT cells.	polyarginine	26-28	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	59-63
23269116-9	2013	PA stimulated greater HEK-CaSR lattice contraction than unstimulated lattices.	polyarginine	0-2	calcium sensing receptor	Homo sapiens	26-30
23269116-11	2013	CONCLUSION: Exposure of intestinal epithelia to the EDGP analog PA stimulates CaSR-dependent ERK phosphorylation and epithelial-mediated collagen lattice contraction.	polyarginine	64-66	calcium sensing receptor	Homo sapiens	78-82
23541572-3	2013	Recombinant Foxp3 protein was fused to a cell penetrating polyarginine (Foxp3-11R) tag to facilitate intracellular transduction.	polyarginine	58-70	forkhead box P3	Mus musculus	12-17
23541572-3	2013	Recombinant Foxp3 protein was fused to a cell penetrating polyarginine (Foxp3-11R) tag to facilitate intracellular transduction.	polyarginine	58-70	forkhead box P3	Mus musculus	72-77
23201851-9	2013	The IC(50) approximately doubled for the polyarginine conjugate and displayed a significant dependence on cell type with IC(50) of 35muM and 54.1muM respectively for SP2 and CHO cells.	polyarginine	41-53	transcription factor Sp2	Cricetulus griseus	166-169
22169985-0	2012	Poly-L-arginine and dextran sulfate-based nanocomplex for epidermal growth factor receptor (EGFR) siRNA delivery: its application for head and neck cancer treatment.	polyarginine	0-15	epidermal growth factor receptor	Homo sapiens	58-90
22169985-0	2012	Poly-L-arginine and dextran sulfate-based nanocomplex for epidermal growth factor receptor (EGFR) siRNA delivery: its application for head and neck cancer treatment.	polyarginine	0-15	epidermal growth factor receptor	Homo sapiens	92-96
25431649-4	2012	Moreover, Arg8CG2 accumulates in cells at nine-fold greater concentrations than the parent CG2 lacking the polyarginine functionality and is retained well in the cell after washing.	polyarginine	107-119	transmembrane protein 245	Homo sapiens	14-17
21682291-2	2011	Polyarginine (P(Arg)) possessing a cell-penetrating activity was used to form the polymer layer onto a negatively charged liposome (lipo-P(Arg)).	polyarginine	0-12	poly(ADP-ribose) glycohydrolase	Homo sapiens	14-20
21910828-0	2011	Insights into the mechanism of enhanced mobilization of hematopoietic progenitor cells and release of CXCL12 by a combination of AMD3100 and aminoglycoside-polyarginine conjugates.	polyarginine	156-168	chemokine (C-X-C motif) ligand 12	Mus musculus	102-108
21654696-0	2011	Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage.	polyarginine	50-62	heme oxygenase 1	Rattus norvegicus	22-38
22169985-1	2012	PURPOSE: A poly-L-arginine (PLR) and dextran sulfate (DEX)-based nano-sized polyelectrolyte complex (nanocomplex) was developed for epidermal growth factor receptor (EGFR) siRNA delivery for the treatment of head and neck cancer.	polyarginine	11-26	epidermal growth factor receptor	Homo sapiens	132-164
22169985-1	2012	PURPOSE: A poly-L-arginine (PLR) and dextran sulfate (DEX)-based nano-sized polyelectrolyte complex (nanocomplex) was developed for epidermal growth factor receptor (EGFR) siRNA delivery for the treatment of head and neck cancer.	polyarginine	11-26	epidermal growth factor receptor	Homo sapiens	166-170
22169985-1	2012	PURPOSE: A poly-L-arginine (PLR) and dextran sulfate (DEX)-based nano-sized polyelectrolyte complex (nanocomplex) was developed for epidermal growth factor receptor (EGFR) siRNA delivery for the treatment of head and neck cancer.	polyarginine	28-31	epidermal growth factor receptor	Homo sapiens	132-164
22169985-1	2012	PURPOSE: A poly-L-arginine (PLR) and dextran sulfate (DEX)-based nano-sized polyelectrolyte complex (nanocomplex) was developed for epidermal growth factor receptor (EGFR) siRNA delivery for the treatment of head and neck cancer.	polyarginine	28-31	epidermal growth factor receptor	Homo sapiens	166-170
21682291-2	2011	Polyarginine (P(Arg)) possessing a cell-penetrating activity was used to form the polymer layer onto a negatively charged liposome (lipo-P(Arg)).	polyarginine	0-12	poly(ADP-ribose) glycohydrolase	Homo sapiens	137-143
21456131-1	2011	The poly(L-Arginine)(PArg)-multiwalled carbon nanotubes (MWCNTs) composite film was used to modify glassy carbon electrode (GCE) to fabricate PArg/MWCNTs/GCE through electropolymerization of L-Arginine on MWCNTs/GCE.	polyarginine	4-20	poly(ADP-ribose) glycohydrolase	Homo sapiens	21-25
21750194-5	2011	Removal of either the STIM1 C-terminal polylysine sequence (amino acids 677-685) or an N-terminal polyarginine sequence in Orai1 (amino acids 28-33) eliminates this differential sensitivity of STIM1-Orai1 association to PtdIns(4,5)P(2) in the distinctive membrane domains.	polyarginine	98-110	ORAI calcium release-activated calcium modulator 1	Homo sapiens	123-128
21750194-5	2011	Removal of either the STIM1 C-terminal polylysine sequence (amino acids 677-685) or an N-terminal polyarginine sequence in Orai1 (amino acids 28-33) eliminates this differential sensitivity of STIM1-Orai1 association to PtdIns(4,5)P(2) in the distinctive membrane domains.	polyarginine	98-110	stromal interaction molecule 1	Homo sapiens	193-198
21750194-5	2011	Removal of either the STIM1 C-terminal polylysine sequence (amino acids 677-685) or an N-terminal polyarginine sequence in Orai1 (amino acids 28-33) eliminates this differential sensitivity of STIM1-Orai1 association to PtdIns(4,5)P(2) in the distinctive membrane domains.	polyarginine	98-110	ORAI calcium release-activated calcium modulator 1	Homo sapiens	199-204
21787231-3	2011	We showed that, when combined to CpG ODN, poly-arginine and poly-histidine, but not poly-lysine or chitosan, enhanced efficiently both the IgG antibody production and the number of splenocytes secreting interferon-gamma after stimulation with a CD8+ T cell-restricted peptide.	polyarginine	42-55	interferon gamma	Homo sapiens	203-219
21303546-7	2011	To enhance release from the endosomal/lysosomal compartment a poly-arginine sequence (R9) was introduced between the CPE and the rGel.	polyarginine	62-75	cpe	Clostridium perfringens	117-120
21456131-1	2011	The poly(L-Arginine)(PArg)-multiwalled carbon nanotubes (MWCNTs) composite film was used to modify glassy carbon electrode (GCE) to fabricate PArg/MWCNTs/GCE through electropolymerization of L-Arginine on MWCNTs/GCE.	polyarginine	4-20	poly(ADP-ribose) glycohydrolase	Homo sapiens	142-146
20652244-9	2010	The polyanionic sites on the surface of VLPs and capsomeres were decorated with a polycationic MUC1 peptide containing a polyarginine-cysteine residue fused to 20 amino acids of the MUC1 tandem repeat through electrostatic interactions and redox-induced disulfide bond formation.	polyarginine	121-133	mucin 1, transmembrane	Mus musculus	95-99
21102426-4	2011	In this study, we generated novel recombinant proteins containing mBAFF, a polyarginine tract 9R and PinX1 (or its C/N terminal), to target lymphoma cells.	polyarginine	75-87	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	66-71
20711426-12	2010	CONCLUSIONS/SIGNIFICANCE: The results clearly demonstrate that damage to the bronchial epithelia by poly-L-arginine stimulates polarized IL-6 and IL-8 secretion.	polyarginine	100-115	interleukin 6	Homo sapiens	137-141
20945489-8	2010	Upstream treatment of cell culture fluid with poly(arginine) resulted in flocculation of solids (cells and cell debris), and antibody recovery and impurity clearance (host cell proteins, DNA and insulin) comparable to the downstream anion exchange chromatography step.	polyarginine	46-60	insulin	Homo sapiens	195-202
20711426-12	2010	CONCLUSIONS/SIGNIFICANCE: The results clearly demonstrate that damage to the bronchial epithelia by poly-L-arginine stimulates polarized IL-6 and IL-8 secretion.	polyarginine	100-115	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
20196153-0	2010	Poly(arginine)-selective coprecipitation properties of self-assembling apoferritin and Its Tb(3+) complex: a new luminescent biotool for sensing of poly(arginine) and its protein conjugates.	polyarginine	0-14	ferritin heavy chain 1	Homo sapiens	71-82
20196153-4	2010	The poly(arginine)-tagged albumin precipitated selectively and quantitatively, so that the apoferritin-Tb(3+) complex can function as a new luminescent biotool for the sensing of poly(arginine) and its protein conjugates.	polyarginine	4-18	ferritin heavy chain 1	Homo sapiens	91-102
20196153-4	2010	The poly(arginine)-tagged albumin precipitated selectively and quantitatively, so that the apoferritin-Tb(3+) complex can function as a new luminescent biotool for the sensing of poly(arginine) and its protein conjugates.	polyarginine	4-17	ferritin heavy chain 1	Homo sapiens	91-102
19963248-2	2010	The transduction of p53 using poly-arginine is useful for targeting and suppressing the growth of bladder cancer cells.	polyarginine	30-43	tumor protein p53	Homo sapiens	20-23
20619096-0	2010	[Expression of a chimeric gene containing poly-arginine as the protein transduction domain and its killing activity against HER2 positive gastric cancer SGC-7901 cells].	polyarginine	42-55	erb-b2 receptor tyrosine kinase 2	Homo sapiens	124-128
20457812-4	2010	Here, we utilized a polyarginine-rich, cell-permeable peptide that represents the portion of the SLP-76 PR region that interacts with the ITK SH3 domain as a competitive inhibitor to disrupt the association between ITK and SLP-76 in live cells.	polyarginine	20-32	lymphocyte cytosolic protein 2	Mus musculus	97-103
20457812-4	2010	Here, we utilized a polyarginine-rich, cell-permeable peptide that represents the portion of the SLP-76 PR region that interacts with the ITK SH3 domain as a competitive inhibitor to disrupt the association between ITK and SLP-76 in live cells.	polyarginine	20-32	IL2 inducible T cell kinase	Mus musculus	138-141
20457812-4	2010	Here, we utilized a polyarginine-rich, cell-permeable peptide that represents the portion of the SLP-76 PR region that interacts with the ITK SH3 domain as a competitive inhibitor to disrupt the association between ITK and SLP-76 in live cells.	polyarginine	20-32	IL2 inducible T cell kinase	Mus musculus	215-218
20457812-4	2010	Here, we utilized a polyarginine-rich, cell-permeable peptide that represents the portion of the SLP-76 PR region that interacts with the ITK SH3 domain as a competitive inhibitor to disrupt the association between ITK and SLP-76 in live cells.	polyarginine	20-32	lymphocyte cytosolic protein 2	Mus musculus	223-229
20196153-3	2010	The apoferritin-Tb(3+) complex assembly exhibited a particularly long-lived green luminescence in aqueous solution, and its poly(arginine)-selective precipitation behavior was followed by monitoring the changes in luminescence.	polyarginine	124-138	ferritin heavy chain 1	Homo sapiens	4-15
19575800-8	2009	Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated.	polyarginine	0-15	interleukin 6	Homo sapiens	46-50
19744531-4	2010	In particular, polyarginine and derivates thereof, i.e. the (RxR)(4) peptide, have been applied with success both in vitro and in vivo.	polyarginine	15-27	retinoid X receptor alpha	Homo sapiens	61-64
19863514-0	2010	Intradermal injections of polyarginine-containing immunogenic antigens preferentially elicit Tc1 and Th1 activation and antitumour immunity.	polyarginine	26-38	negative elongation factor complex member C/D, Th1l	Mus musculus	101-104
19575800-8	2009	Poly-L-arginine enhanced the stimulus-induced IL-6 and IL-8 production, however, blocking arginine uptake and the enhanced IL-6 and IL-8 production appeared unrelated.	polyarginine	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	55-59
19575800-9	2009	The exaggerated IL-6 and IL-8 production due to arginine deficiency and to poly-L-arginine depend on a post-transcriptional and a transcriptional process, respectively.	polyarginine	75-90	interleukin 6	Homo sapiens	16-20
19575800-9	2009	The exaggerated IL-6 and IL-8 production due to arginine deficiency and to poly-L-arginine depend on a post-transcriptional and a transcriptional process, respectively.	polyarginine	75-90	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
17931154-4	2007	Combining oligodeoxynucleotides with poly-L-arginine (IC30) or certain artificial antimicrobial peptides dramatically improves and synergizes with the adjuvant action of TLR9 agonists, a notion that has prompted the development of IC31, an adjuvant with a promising profile in both preclinical and clinical trials.	polyarginine	37-52	toll like receptor 9	Homo sapiens	170-174
19120069-8	2009	Furthermore, we have shown that the pro-angiogenic effect of MBP is not due to its cationic charge since stimulation of the CAMs with the synthetic polycation, poly-L-arginine does not induce any angiogenic effects.	polyarginine	160-175	myelin basic protein	Homo sapiens	61-64
18626112-2	2008	A 9-amino-acid peptide derived from full-length TR3 with polyarginine tail (TR3-r8) recapitulates TR3"s binding specificity, displaying high affinity for Bcl-B.	polyarginine	57-69	nuclear receptor subfamily 4 group A member 1	Homo sapiens	48-51
18626112-2	2008	A 9-amino-acid peptide derived from full-length TR3 with polyarginine tail (TR3-r8) recapitulates TR3"s binding specificity, displaying high affinity for Bcl-B.	polyarginine	57-69	nuclear receptor subfamily 4 group A member 1	Homo sapiens	76-79
18626112-2	2008	A 9-amino-acid peptide derived from full-length TR3 with polyarginine tail (TR3-r8) recapitulates TR3"s binding specificity, displaying high affinity for Bcl-B.	polyarginine	57-69	nuclear receptor subfamily 4 group A member 1	Homo sapiens	76-79
18626112-2	2008	A 9-amino-acid peptide derived from full-length TR3 with polyarginine tail (TR3-r8) recapitulates TR3"s binding specificity, displaying high affinity for Bcl-B.	polyarginine	57-69	BCL2 like 10	Homo sapiens	154-159
18673146-0	2008	A novel polyarginine containing Smac peptide conjugate that mediates cell death in tumor and healthy cells.	polyarginine	8-20	diablo IAP-binding mitochondrial protein	Homo sapiens	32-36
18816557-4	2008	The three-cycle depositions of poly-L-arginine (PLA) and human serum albumin (HSA, M(w)=66.5 kDa) into the porous PC template (pore diameter, D(p)=400 nm) yielded well-defined (PLA/HSA)(3) nanotubes with an outer diameter of 419+/-29 nm and a wall thickness of 46+/-8 nm, revealed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations.	polyarginine	31-46	albumin	Homo sapiens	181-184
18978176-2	2009	MBP and its mimetic polyarginine activate the calcium sensing receptor (CaSR) on oesophageal epithelium.	polyarginine	20-32	calcium sensing receptor	Homo sapiens	46-70
18978176-2	2009	MBP and its mimetic polyarginine activate the calcium sensing receptor (CaSR) on oesophageal epithelium.	polyarginine	20-32	calcium sensing receptor	Homo sapiens	72-76
18978176-10	2009	RESULTS: FGF9 was secreted by HET-1A cells treated with polyarginine and MBP-peptide, but not calcium.	polyarginine	56-68	fibroblast growth factor 9	Homo sapiens	9-13
18052064-9	2007	Thus, Lysozyme could be turned off, on, and off again by consecutive addition of the polymeric inhibitor, polyarginine, and polymer again.	polyarginine	106-118	lysozyme	Homo sapiens	6-14
17686555-4	2007	IFNgamma production was dependent on formulation of the synthetic peptides with the adjuvant poly-l-arginine.	polyarginine	93-108	interferon gamma	Homo sapiens	0-8
16982928-5	2006	Cell stimulation with the synthetic polycation, poly-L-arginine, reproduced some but not all effects of MBP and EPO.	polyarginine	48-63	myelin basic protein	Homo sapiens	104-107
17165763-3	2006	We show that a GPNA oligomer designed to bind to the transcriptional start-site of human E-cadherin gene induces potent and sequence-specific antisense effects and is less toxic to the cells than the corresponding PNA-polyarginine conjugate.	polyarginine	218-230	cadherin 1	Homo sapiens	89-99
16982928-5	2006	Cell stimulation with the synthetic polycation, poly-L-arginine, reproduced some but not all effects of MBP and EPO.	polyarginine	48-63	eosinophil peroxidase	Homo sapiens	112-115
16838365-6	2006	On the other hand, the protein transduction of SCG10 using a polyarginine tag stimulated neurite outgrowth.	polyarginine	61-73	stathmin 2	Rattus norvegicus	47-52
16581161-9	2006	Poly-L-arginine was required for the aimed-for Th1/Tc1-type immunity (IFN-gamma secreting T cells).	polyarginine	0-15	negative elongation factor complex member C/D	Homo sapiens	47-50
16581161-9	2006	Poly-L-arginine was required for the aimed-for Th1/Tc1-type immunity (IFN-gamma secreting T cells).	polyarginine	0-15	interferon gamma	Homo sapiens	51-79
16132358-2	2005	METHODS: Crystals of recombinant human growth hormone were coated with a monomolecular layer of positively charged poly(arginine).	polyarginine	115-129	growth hormone 1	Homo sapiens	39-53
16132358-3	2005	The pharmacokinetics and pharmacodynamics of this poly(arginine)-coated human growth hormone crystalline formulation were determined in hypophysectomized rats and monkeys.	polyarginine	50-64	growth hormone 1	Homo sapiens	78-92
16132358-4	2005	RESULTS: Here we have demonstrated for the first time that crystals of human growth hormone coated with positively charged poly(arginine) allowed for in vivo pharmacokinetic release profiles of over several days in animal models.	polyarginine	123-137	growth hormone 1	Homo sapiens	77-91
15996664-1	2005	Protein transduction therapy using poly-arginine can deliver the bioactive p53 protein into cancer cells and inhibits the proliferation of the cells.	polyarginine	35-48	tumor protein p53	Homo sapiens	75-78
14661930-0	2003	Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.	polyarginine	0-15	occludin	Oryctolagus cuniculus	130-138
15864572-7	2005	However, mixing a polyanion, either poly-aspartate or osteopontin, with the polycation poly-arginine, changed their behavior from disaggregation to aggregation promotion.	polyarginine	87-100	secreted phosphoprotein 1	Homo sapiens	54-65
15800129-7	2005	After 24 h of gentamicin treatment, OK cell proliferation was observed, whereas after 4 d, the OK cells underwent cell death, an effect that was mimicked by the CaR agonists spermine and polyarginine.	polyarginine	187-199	calcium sensing receptor	Homo sapiens	161-164
15371436-0	2004	Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection.	polyarginine	0-12	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	22-27
15371436-0	2004	Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection.	polyarginine	0-12	furin, paired basic amino acid cleaving enzyme	Homo sapiens	42-47
15371436-4	2004	Arg-Arg-Arg-Arg-Arg-Arg or longer iterations of polyarginine have been shown to be competitive inhibitors of substrate cleavage by furin.	polyarginine	48-60	furin, paired basic amino acid cleaving enzyme	Homo sapiens	131-136
15371436-7	2004	Using a fluorogenic assay, we demonstrated that polyarginine potently inhibited substrate-specific proteolytic cleavage by furin.	polyarginine	48-60	furin, paired basic amino acid cleaving enzyme	Homo sapiens	123-128
15371436-8	2004	Moreover, we verified that authentic processing of human immunodeficiency virus-1 gp160 synthesized in human cells from an infectious human immunodeficiency virus-1 (HIV-1) molecular clone was effectively blocked by polyarginine.	polyarginine	216-228	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	82-87
15197180-0	2004	Inhibition of furin by polyarginine-containing peptides: nanomolar inhibition by nona-D-arginine.	polyarginine	23-35	furin, paired basic amino acid cleaving enzyme	Homo sapiens	14-19
15551755-2	2004	A previous study showed that 11 poly-arginine fused p53 protein (11R-p53) effectively penetrated across the plasma membrane and inhibited the proliferation of oral cancer cells.	polyarginine	32-45	tumor protein p53	Homo sapiens	52-55
15551755-2	2004	A previous study showed that 11 poly-arginine fused p53 protein (11R-p53) effectively penetrated across the plasma membrane and inhibited the proliferation of oral cancer cells.	polyarginine	32-45	tumor protein p53	Homo sapiens	69-72
15200153-1	2004	The extracellular calcium-sensing receptor (CaR) is a versatile sensor of small, polycationic molecules ranging from Ca2+ and Mg2+ through polyarginine, spermine, and neomycin.	polyarginine	139-151	calcium sensing receptor	Homo sapiens	18-42
15200153-1	2004	The extracellular calcium-sensing receptor (CaR) is a versatile sensor of small, polycationic molecules ranging from Ca2+ and Mg2+ through polyarginine, spermine, and neomycin.	polyarginine	139-151	calcium sensing receptor	Homo sapiens	44-47
14661930-7	2003	CONCLUSIONS: We conclude that poly-L-Arg enhances the paracellular permeability of FD-4 (i.e., macromolecules), at least, by way of both serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.	polyarginine	30-40	occludin	Oryctolagus cuniculus	212-220
14559854-0	2003	Correspondence re: L. Yang et al., Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.	polyarginine	179-191	diablo IAP-binding mitochondrial protein	Homo sapiens	203-207
12636152-4	2003	Immunolocalization of junction proteins (ZO-1, occludin, and E-cadherin) after treatment with poly-L-Arg was also observed.	polyarginine	94-104	occludin	Oryctolagus cuniculus	47-55
12649428-3	2003	We show here that alpha-synuclein interacts with different unstructured polycations (spermine, polylysine, polyarginine, and polyethyleneimine) to form specific complexes.	polyarginine	107-119	synuclein alpha	Homo sapiens	18-33
12591734-0	2003	Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide.	polyarginine	144-156	diablo IAP-binding mitochondrial protein	Homo sapiens	168-172
14508232-4	2003	LPS-induced monocytic tissue factor (mTF) procoagulation was readily offset by poly-L-lysine (PLK), poly-L-arginine (PLR), or poly-L-ornithine (POR) included in single-stage clotting assays.	polyarginine	100-115	melanotransferrin	Mus musculus	37-40
12636152-12	2003	Immunofluorescence of ZO-1, occludin, and E-cadherin in cell-to-cell junctions was reduced and distributed into the cytoplasm by apical application of poly-L-Arg, suggesting that poly-L-Arg regulates the junction proteins to enhance paracellular permeability across the nasal epithelium.	polyarginine	151-161	occludin	Oryctolagus cuniculus	28-36
12636152-12	2003	Immunofluorescence of ZO-1, occludin, and E-cadherin in cell-to-cell junctions was reduced and distributed into the cytoplasm by apical application of poly-L-Arg, suggesting that poly-L-Arg regulates the junction proteins to enhance paracellular permeability across the nasal epithelium.	polyarginine	179-189	occludin	Oryctolagus cuniculus	28-36
10392762-3	1999	A number a studies have established that MBP actions could be mimicked by synthetic polycations as poly-L-arginine.	polyarginine	99-114	myelin basic protein	Cavia porcellus	41-44
12438368-3	2002	As CAP37 and protamines share high levels of arginine content, we tested different synthetic poly-L-amino acids and found that poly-L-arginine, and to a lesser extent poly-L-lysine, increased IL-8 production in LPS-stimulated human whole blood.	polyarginine	127-142	azurocidin 1	Homo sapiens	3-8
12438368-3	2002	As CAP37 and protamines share high levels of arginine content, we tested different synthetic poly-L-amino acids and found that poly-L-arginine, and to a lesser extent poly-L-lysine, increased IL-8 production in LPS-stimulated human whole blood.	polyarginine	127-142	C-X-C motif chemokine ligand 8	Homo sapiens	192-196
12438368-5	2002	In agreement with observations previously reported for CAP37, the LPS-enhancing effect of poly-L-arginine was completely abolished upon antibody blockade of the human LPS receptor, CD14.	polyarginine	90-105	azurocidin 1	Homo sapiens	55-60
12438368-5	2002	In agreement with observations previously reported for CAP37, the LPS-enhancing effect of poly-L-arginine was completely abolished upon antibody blockade of the human LPS receptor, CD14.	polyarginine	90-105	CD14 molecule	Homo sapiens	181-185
12372772-2	2002	Exposure of mTAL cells to either Ca(o)(2+) or the CaR-selective agonist poly-L-arginine increased TNF-alpha synthesis.	polyarginine	72-87	tumor necrosis factor	Homo sapiens	98-107
12137242-3	2002	AIM: To investigate the effect of synthetic cationic polypeptides such as poly-L-arginine, which can mimic the effect of MBP, on airway epithelial cells.	polyarginine	74-89	myelin basic protein	Homo sapiens	121-124
11880385-6	2002	Not only Ca(2+), but also several other Ca(2+) receptor-specific agonists, Mg(2+), Gd(3+), spermine, and poly-l-Arginine, can activate T903-Rhoc truncated receptor-initiated phosphoinositide hydrolysis in HEK 293 cells.	polyarginine	105-120	ras homolog family member C	Homo sapiens	140-144
11880385-9	2002	Alanine substitution of all the acidic residues in the second extracellular loop of the T903-Rhoc receptor significantly impairs activation by metal ions and organic polycations in the presence of NPS 568 but not the synergistic activation of Ca(2+) with poly-l-Arginine.	polyarginine	255-270	ras homolog family member C	Homo sapiens	93-97
10958789-0	2000	Polyarginines are potent furin inhibitors.	polyarginine	0-13	furin, paired basic amino acid cleaving enzyme	Homo sapiens	25-30
11553512-4	2001	Challenge with the CaR-selective agonist poly-L-arginine (PLA) also increased COX-2 mRNA accumulation, protein expression, and PGE(2) synthesis.	polyarginine	41-56	calcium sensing receptor	Homo sapiens	19-22
11553512-4	2001	Challenge with the CaR-selective agonist poly-L-arginine (PLA) also increased COX-2 mRNA accumulation, protein expression, and PGE(2) synthesis.	polyarginine	41-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	78-83
11222721-0	2001	Exchange of the basic domain of human immunodeficiency virus type 1 Rev for a polyarginine stretch expands the RNA binding specificity, and a minimal arginine cluster is required for optimal RRE RNA binding affinity, nuclear accumulation, and trans-activation.	polyarginine	78-90	Rev	Human immunodeficiency virus 1	68-71
11222721-4	2001	However, polyarginine substitutions expanded the RNA binding specificity of the resultant mutant Rev protein.	polyarginine	9-21	Rev	Human immunodeficiency virus 1	97-100
11222721-5	2001	Polyarginine insertions in place of residues 24 to 60 that excised the RNA binding and oligomerization domains of Rev preserved the activation for MS2 RNA, but not for the RRE.	polyarginine	0-12	Rev	Human immunodeficiency virus 1	114-117
11222721-5	2001	Polyarginine insertions in place of residues 24 to 60 that excised the RNA binding and oligomerization domains of Rev preserved the activation for MS2 RNA, but not for the RRE.	polyarginine	0-12	MS2	Homo sapiens	147-150
11012615-8	2000	The induction of IL-8 mRNA by poly-L-arginine was significantly inhibited by actinomycin D.	polyarginine	30-45	C-X-C motif chemokine ligand 8	Homo sapiens	17-21
10392762-9	1999	Intratracheal treatment with poly-L-arginine (100 nmol/animal) produced an important increase of beta-glucuronidase, histamine, eosinophil peroxidase (EPO) and albumin levels in BAL fluid, whereas the intravenous treatment (500 nmol/animal) did not.	polyarginine	29-44	eosinophil peroxidase	Cavia porcellus	128-149
10392762-9	1999	Intratracheal treatment with poly-L-arginine (100 nmol/animal) produced an important increase of beta-glucuronidase, histamine, eosinophil peroxidase (EPO) and albumin levels in BAL fluid, whereas the intravenous treatment (500 nmol/animal) did not.	polyarginine	29-44	eosinophil peroxidase	Cavia porcellus	151-154
10392762-11	1999	Moreover, poly-L-arginine appeared to induce other inflammatory responses since it increased beta-glucuronidase, histamine, EPO and albumin levels in BAL fluid following intratracheal treatment.	polyarginine	10-25	eosinophil peroxidase	Cavia porcellus	124-127
10025952-2	1999	We show that highly basic proteins including the homopolypeptides poly-arginine, poly-lysine and poly-ornithine, core histones, spermatid-specific S1 protein and the protamines HP3 and Z3 were strong inhibitors of angiogenin binding to RI.	polyarginine	66-79	angiogenin	Homo sapiens	214-224
9497395-11	1998	Competition experiments with poly-L-arginine, poly-L-lysine, and protamine reveal that yNAP-1 binds to core and linker histones more tightly despite the much higher positive charge densities of the former molecules.	polyarginine	29-44	histone chaperone NAP1	Saccharomyces cerevisiae S288C	87-93
9357760-3	1997	CaR agonists (Ca2+, poly-L-arginine, protamine) mediated an increase in intracellular Ca2+ in HT-29-18-C1 cells (monitored by changes in fura 2 fluorescence), which was dependent on release from thapsigargin-sensitive stores.	polyarginine	20-35	calcium sensing receptor	Homo sapiens	0-3
9315692-0	1997	Reversible, site-specific immobilization of polyarginine-tagged fusion proteins on mica surfaces.	polyarginine	44-56	MHC class I polypeptide-related sequence A	Homo sapiens	83-87
9143230-11	1997	Poly-L-arginine (10(-6) M) and poly-L-lysine (10(-6) M) abolished endothelium-dependent relaxations in response to bradykinin (10(-10)-10(-6) M) or calcium ionophore A23187 (10(-9)-10(-6) M).	polyarginine	0-15	kininogen 1	Canis lupus familiaris	115-125
9142932-5	1997	Here, we report that the polycations PLys and polyarginine (PArg) induce phospholipase D (PLD) activation in ECs.	polyarginine	46-58	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	73-88
9142932-5	1997	Here, we report that the polycations PLys and polyarginine (PArg) induce phospholipase D (PLD) activation in ECs.	polyarginine	46-58	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	90-93
9142932-5	1997	Here, we report that the polycations PLys and polyarginine (PArg) induce phospholipase D (PLD) activation in ECs.	polyarginine	60-64	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	73-88
9142932-5	1997	Here, we report that the polycations PLys and polyarginine (PArg) induce phospholipase D (PLD) activation in ECs.	polyarginine	60-64	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	90-93
9143230-12	1997	Heparin (50 U/ml) and dextran sulfate (200 mg/ml) restored endothelium-dependent relaxations to bradykinin (10(-10)-10(-6) M) in arteries exposed to poly-L-arginine (10(-6) M) or poly-L-lysine (10(-6) M).	polyarginine	149-164	kininogen 1	Canis lupus familiaris	96-106
8806714-7	1996	This phosphorylation of CaM is dependent upon the presence of basic peptides such as poly-L-arginine (optimal basic peptide/CaM ratio = 0.08) and is stimulated by saturating [Ca2+] (K0.5 = 16 microM).	polyarginine	85-100	calmodulin	Bos taurus	24-27
8806714-7	1996	This phosphorylation of CaM is dependent upon the presence of basic peptides such as poly-L-arginine (optimal basic peptide/CaM ratio = 0.08) and is stimulated by saturating [Ca2+] (K0.5 = 16 microM).	polyarginine	85-100	calmodulin	Bos taurus	124-127
8679688-8	1996	By contrast, the basic polypeptides poly(L-arginine) and poly(L-lysine) potently inhibited sPLA2 activity, indicating the important role of basic amino acids in the inhibitory effect evoked by protamine.	polyarginine	36-52	phospholipase A2 group IIA	Homo sapiens	91-96
8663258-5	1996	The binding was inhibited by CK2 effectors such as heparin, polyarginine, and histone H1, but was not affected by the CK2 substrate, casein.	polyarginine	60-72	casein kinase 2, alpha prime polypeptide	Mus musculus	29-32
8666820-9	1996	They were, however, at least partially charge mediated, since heparin abolished the effects of MBP on IL-1-stimulated cells, and the surrogate cationic molecule poly-L-arginine mimicked the stimulatory effects of MBP on fibroblast IL-6-type cytokine elaboration.	polyarginine	161-176	myelin basic protein	Homo sapiens	213-216
8666820-9	1996	They were, however, at least partially charge mediated, since heparin abolished the effects of MBP on IL-1-stimulated cells, and the surrogate cationic molecule poly-L-arginine mimicked the stimulatory effects of MBP on fibroblast IL-6-type cytokine elaboration.	polyarginine	161-176	interleukin 6	Homo sapiens	231-235
8679688-9	1996	Activities of the human recombinant sPLA2 and the unpurified synovial enzyme of patients with rheumatoid arthritis were also inhibited by the same range of protamine, poly(L-arginine) and poly(L-lysine) concentrations.	polyarginine	167-183	phospholipase A2 group IIA	Homo sapiens	36-41
8792334-4	1996	MAP1 kinase A is a novel protein kinase that is remarkably activated by poly-L-lysine and poly-L-arginine, but very insensitive to heparin among the kinases.	polyarginine	90-105	kininogen 2	Rattus norvegicus	0-4
7772032-1	1995	Spermine and polyarginine have been shown to increase the rate of dissociation of Ca2+ from the Ca(2+)-ATPase of skeletal-muscle sarcoplasmic reticulum.	polyarginine	13-25	dynein axonemal heavy chain 8	Homo sapiens	103-109
8576120-12	1996	Positively charged peptides of polyarginine mimicked the effect of apoE-rich HDL in reducing the 125I-ModOxLDL retention; however, polylysine had no effect.	polyarginine	31-43	apolipoprotein E	Homo sapiens	67-71
7627718-7	1995	Furthermore, polyarginine or polylysine markedly decreased 125I-LDL binding to LPL-containing matrix, whereas polyleucine was ineffective.	polyarginine	13-25	lipoprotein lipase	Homo sapiens	79-82
7772032-3	1995	Polyarginine itself also decreases the fluorescence intensity of DMC-labelled ATPase.	polyarginine	0-12	dynein axonemal heavy chain 8	Homo sapiens	78-84
7772032-4	1995	These results are consistent with binding of spermine and polyarginine to a gating site controlling the rate of access of Ca2+ to its binding sites on the ATPase.	polyarginine	58-70	dynein axonemal heavy chain 8	Homo sapiens	155-161
7772032-6	1995	Spermine, polyarginine and PLN-(1-25) all increased the equilibrium constant E1/E2, and spermine and polyarginine increased the rate of Ca2+ binding to the ATPase, consistent with an increase in the rate of the E2-->E1 transition.	polyarginine	10-22	small nucleolar RNA, H/ACA box 73A	Homo sapiens	77-82
7772032-6	1995	Spermine, polyarginine and PLN-(1-25) all increased the equilibrium constant E1/E2, and spermine and polyarginine increased the rate of Ca2+ binding to the ATPase, consistent with an increase in the rate of the E2-->E1 transition.	polyarginine	101-113	dynein axonemal heavy chain 8	Homo sapiens	156-162
18623263-12	1995	Little effect on partitioning was observed when the protein and polymer had the same charge, with the exception of beta-galactosidase with polyarginine tails.	polyarginine	139-151	galactosidase beta 1	Homo sapiens	115-133
8161533-1	1994	The ATPase activity of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum is inhibited by a variety of polyamines, including spermine, spermidine, and poly(arginine).	polyarginine	160-174	dynein axonemal heavy chain 8	Homo sapiens	4-10
7527430-1	1994	We have previously reported that human eosinophil granule major basic protein and synthetic cationic proteins such as poly-L-arginine and poly-L-lysine, can increase airway responsiveness in vivo.	polyarginine	118-133	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	39-77
7961591-7	1994	The compounds enhancing the EGF-R activity, such as poly-L-lysine, protamine, and poly-L-arginine, down-modulated the autophosphorylation reaction.	polyarginine	82-97	epidermal growth factor receptor	Homo sapiens	28-33
8161533-1	1994	The ATPase activity of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum is inhibited by a variety of polyamines, including spermine, spermidine, and poly(arginine).	polyarginine	160-174	dynein axonemal heavy chain 8	Homo sapiens	34-40
8155651-5	1994	The activity of CK2 holoenzyme, either native or reconstituted, toward calmodulin can be elicited by a variety of polybasic effectors, including polylysine, polyarginine, salmine, and histones H4, H3, and, to a lesser extent, H2a and H2b.	polyarginine	157-169	calmodulin 1	Homo sapiens	71-81
8130075-4	1993	Polybasic substances such as poly-L-arginine, histone H1 and protamine sulphate all promoted calmodulin phosphorylation by the insulin receptor in a similar biphasic dose-dependent fashion.	polyarginine	29-44	calmodulin 1	Homo sapiens	93-103
8206646-0	1994	Human recombinant platelet phospholipase A2 exacerbates poly-L-arginine induced rat paw edema.	polyarginine	56-71	phospholipase A2 group IIA	Rattus norvegicus	18-43
8206646-3	1994	Furthermore when r-hnps-PLA2 (1-10 micrograms) was injected together with a subliminal dose of poly-L-arginine (50 micrograms/paw), a dose-dependent increase in both edema and protein leakage was observed.	polyarginine	95-110	phospholipase A2 group IIA	Homo sapiens	17-28
8130075-4	1993	Polybasic substances such as poly-L-arginine, histone H1 and protamine sulphate all promoted calmodulin phosphorylation by the insulin receptor in a similar biphasic dose-dependent fashion.	polyarginine	29-44	insulin receptor	Homo sapiens	127-143
1444466-2	1992	Polylysine and polyarginine increase autophosphorylation of the alpha-subunit with a concomitant decrease in beta-subunit phosphorylation, while enhancing casein kinase II-stimulated phosphorylation of calmodulin over 100-fold.	polyarginine	15-27	calmodulin 1	Homo sapiens	202-212
1661148-10	1991	In contrast, another polycation, polyarginine, affected both TPKs in a manner quite different from polylysine: Polyarginine stimulated insulin receptor autophosphorylation to a greater extent than polylysine did while it had a very small effect on the IGF-I receptor autophosphorylation as well as the exogenous substrate phosphorylation activities of the two receptor TPKs.	polyarginine	33-45	insulin receptor	Homo sapiens	135-151
1370607-4	1992	Poly(L-lysine), poly(L-arginine) and protamine stimulated EGF receptor kinase activity by 3-5-fold at non-saturating doses of ATP and peptide substrate, while poly(L-glutamate) had no effect.	polyarginine	16-32	epidermal growth factor receptor	Homo sapiens	58-70
1661148-10	1991	In contrast, another polycation, polyarginine, affected both TPKs in a manner quite different from polylysine: Polyarginine stimulated insulin receptor autophosphorylation to a greater extent than polylysine did while it had a very small effect on the IGF-I receptor autophosphorylation as well as the exogenous substrate phosphorylation activities of the two receptor TPKs.	polyarginine	33-45	insulin like growth factor 1 receptor	Homo sapiens	252-266
1661148-10	1991	In contrast, another polycation, polyarginine, affected both TPKs in a manner quite different from polylysine: Polyarginine stimulated insulin receptor autophosphorylation to a greater extent than polylysine did while it had a very small effect on the IGF-I receptor autophosphorylation as well as the exogenous substrate phosphorylation activities of the two receptor TPKs.	polyarginine	111-123	insulin receptor	Homo sapiens	135-151
1661148-10	1991	In contrast, another polycation, polyarginine, affected both TPKs in a manner quite different from polylysine: Polyarginine stimulated insulin receptor autophosphorylation to a greater extent than polylysine did while it had a very small effect on the IGF-I receptor autophosphorylation as well as the exogenous substrate phosphorylation activities of the two receptor TPKs.	polyarginine	111-123	insulin like growth factor 1 receptor	Homo sapiens	252-266
2306477-4	1990	Various basic amino-acid homopolymers are also potent, apparently competitive inhibitors of wheat embryo CDPK, namely poly(L-lysine) (IC50 2 nM), poly(L-ornithine) (IC50 3 nM) and poly(L-arginine) (IC50 17 nM) and also inhibit the leaf CDPKs, albeit at higher concentrations.	polyarginine	180-196	calcium-dependent protein kinase 19	Triticum aestivum	105-109
1900197-8	1991	The eCRP formed a precipitin line with histone, protamine, poly(L-lysine) and poly(L-arginine) in agarose gel.	polyarginine	78-94	ribonuclease A family member 2C, pseudogene	Homo sapiens	4-8
2168890-10	1990	Poly-L-arginine, an inhibitor for aFGF binding to the receptor, appeared to stimulate the mitogenesis or cell growth of responsive cells by mimicking aFGF activity.	polyarginine	0-15	fibroblast growth factor 1	Bos taurus	34-38
2168890-10	1990	Poly-L-arginine, an inhibitor for aFGF binding to the receptor, appeared to stimulate the mitogenesis or cell growth of responsive cells by mimicking aFGF activity.	polyarginine	0-15	fibroblast growth factor 1	Bos taurus	150-154
3233203-3	1988	We found that the binding of fucan to bindin or polyarginine is stable at the ionic strength of seawater, whereas the binding of fucan to polylysine or polyhistidine is inhibited by 50% or more at this ionic strength.	polyarginine	48-60	bindin	Strongylocentrotus purpuratus	18-24
34469733-5	2021	Overexpression of wild-type or non-complementing Rli1 and loss of Rps7A ubiquitination enable Not4 E3 ligase-dependent translation of polyarginine stretches.	polyarginine	134-146	ATP binding cassette subfamily E member 1	Homo sapiens	49-53
34469733-5	2021	Overexpression of wild-type or non-complementing Rli1 and loss of Rps7A ubiquitination enable Not4 E3 ligase-dependent translation of polyarginine stretches.	polyarginine	134-146	CCR4-NOT transcription complex subunit 4	Homo sapiens	94-98
2557012-6	1989	At a concentration of 1 microM, poly(L-lysine) and poly(L-ornithine) markedly stimulated kinase activity, whereas poly(L-arginine) and histones H1 and H2B inhibited insulin receptor kinase.	polyarginine	114-129	insulin	Homo sapiens	165-172
26246181-0	2016	Poly-L-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells.	polyarginine	0-15	interleukin 6	Homo sapiens	72-76
26246181-0	2016	Poly-L-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells.	polyarginine	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
26246181-0	2016	Poly-L-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells.	polyarginine	0-15	mitogen-activated protein kinase 1	Homo sapiens	90-93
26246181-0	2016	Poly-L-Arginine Acts Synergistically with LPS to Promote the Release of IL-6 and IL-8 via p38/ERK Signaling Pathways in NCI-H292 Cells.	polyarginine	0-15	mitogen-activated protein kinase 1	Homo sapiens	94-97
26246181-2	2016	The pharmacological function of MBP can be mimicked by poly-L-arginine (PLA), however, the potential signaling mechanisms of LPS-PLA-induced release of the inflammatory cytokines interleukin (IL)-6 and IL-8 remain unclear.	polyarginine	55-70	myelin basic protein	Homo sapiens	32-35
26246181-2	2016	The pharmacological function of MBP can be mimicked by poly-L-arginine (PLA), however, the potential signaling mechanisms of LPS-PLA-induced release of the inflammatory cytokines interleukin (IL)-6 and IL-8 remain unclear.	polyarginine	55-70	C-X-C motif chemokine ligand 8	Homo sapiens	202-206
34393544-3	2021	The expression levels of IL-8 and IL-17 in LPS/poly-L-arginine (PLA) and FEMP-cotreated A549 cells were lower than those in LPS/PLA only-treated cells.	polyarginine	47-62	interleukin 17A	Mus musculus	34-39
34341336-0	2021	Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.	polyarginine	0-15	fibroblast growth factor binding protein 1	Mus musculus	66-72
34341336-0	2021	Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.	polyarginine	0-15	CREB regulated transcription coactivator 1	Mus musculus	122-128
34341336-0	2021	Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway.	polyarginine	0-15	signal transducer and activator of transcription 3	Mus musculus	129-134
34341336-3	2021	In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP.	polyarginine	160-175	fibroblast growth factor binding protein 1	Mus musculus	36-78
34341336-3	2021	In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP.	polyarginine	160-175	fibroblast growth factor binding protein 1	Mus musculus	80-86
34341336-3	2021	In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP.	polyarginine	160-175	myelin basic protein	Mus musculus	194-197
34341336-3	2021	In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP.	polyarginine	177-180	fibroblast growth factor binding protein 1	Mus musculus	36-78
34341336-3	2021	In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP.	polyarginine	177-180	fibroblast growth factor binding protein 1	Mus musculus	80-86
34341336-3	2021	In this study, we demonstrated that fibroblast growth factor-binding protein 1 (FGFBP1) was dramatically upregulated in airway epithelial cell lines treated by poly-L-arginine (PLA), a mimic of MBP.	polyarginine	177-180	myelin basic protein	Mus musculus	194-197
2480780-6	1989	Some of these basic proteins, i.e. polylysine, polyarginine, polyornithine, protamine sulphate and histones H1 and H2B, were also able to stimulate the phosphorylation of calmodulin via an insulin-independent activation of the receptor tyrosine kinase.	polyarginine	47-59	calmodulin 1	Homo sapiens	171-181
2469646-7	1989	Histamine release stimulated by a 13,900 MW poly-L-arginine exhibited a dissimilar pharmacological profile from that of MBP.	polyarginine	44-59	myelin basic protein	Homo sapiens	120-123
2928301-4	1989	These variations are partly caused by a PK-C isozyme that prefers poly(arginine,serine) over histone as substrate.	polyarginine	66-79	protein kinase C, gamma	Rattus norvegicus	40-44
2928301-10	1989	The phosphorylation of poly-(arginine,serine) is very sensitive to low concentrations of staurosporin and is inhibited by PK-C antibody, but, in contrast to histone phosphorylation, it is resistant to sphingosine and polymyxin B.	polyarginine	23-37	protein kinase C, gamma	Rattus norvegicus	122-126
2450171-10	1988	Synthetic polycationic peptides such as polylysine and polyarginine mimic the effects of MBP, suggesting that the high-affinity cannabinoid binding site recognizes large polycations.	polyarginine	55-67	myelin basic protein	Rattus norvegicus	89-92
3415247-2	1988	Calmodulin is phosphorylated in the presence of polylysine, histone Hf2b, and protamine sulfate, but not in the absence of these cofactors or in the presence of other basic compounds known to interact with calmodulin, such as mellitin, myelin basic protein, chlorpromazine, trifluoperazine, substance P, glucagon, polyarginine, mastoparin, beta-endorphin, spermine, spermidine, and putrescine.	polyarginine	314-326	calmodulin 1	Homo sapiens	0-10
2866513-6	1985	Polyarginine and polyethylenimine also supported CAP2 phosphorylation, but arginine and lysine were ineffective.	polyarginine	0-12	cyclase associated actin cytoskeleton regulatory protein 2	Bos taurus	49-53
3593703-10	1987	Poly(L-lysine) and poly(L-arginine), two potent inhibitors of PKC, also showed substrate-dependent inhibition characteristics.	polyarginine	19-35	proline rich transmembrane protein 2	Homo sapiens	62-65
3708546-3	1986	The polycation poly-L-arginine (PLA) can artificially fix CRP to target cells.	polyarginine	15-30	C-reactive protein	Oryctolagus cuniculus	58-61
3708546-3	1986	The polycation poly-L-arginine (PLA) can artificially fix CRP to target cells.	polyarginine	32-35	C-reactive protein	Oryctolagus cuniculus	58-61
3853779-3	1985	Poly-arginine inhibited the interaction between serine tRNA and SerRS.	polyarginine	0-13	seryl-tRNA synthetase 1	Bos taurus	64-69