PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8166664-5	1994	Gangliosides, especially the GM3 ganglioside, but not other glycosphingolipids, inhibited the activity of the 39 kDa phospholipase A2 in a dose-dependent manner.	G(M3) Ganglioside	29-44	LOC104974671	Bos taurus	117-133
1634229-3	1992	Labelled GM2 ganglioside accumulated in 4 variants of GM2 gangliosidosis, whereas labelled GM3 ganglioside accumulated in sialidosis, galactosialidoses and sphingolipid activator protein 1 (SAP-1, saposin B) and prosaposin (saposin A, B, C and D) deficient lipidoses.	G(M3) Ganglioside	91-106	prosaposin	Homo sapiens	156-188
8395211-2	1993	A specific plasma membrane glycosphingolipid, known as ganglioside GM3, can regulate the intrinsic tyrosyl kinase activity of the epidermal growth factor (EGF) receptor; this modulation is not associated with alterations in hormone binding to the receptor.	G(M3) Ganglioside	55-70	epidermal growth factor receptor	Homo sapiens	130-168
1634229-4	1992	The reduced degradation of GM3 ganglioside in the SAP-1 and prosaposin deficiencies was attributed to the deficient function of SAP-1.	G(M3) Ganglioside	27-42	prosaposin	Homo sapiens	50-55
1634229-4	1992	The reduced degradation of GM3 ganglioside in the SAP-1 and prosaposin deficiencies was attributed to the deficient function of SAP-1.	G(M3) Ganglioside	27-42	prosaposin	Homo sapiens	128-133
1998515-0	1991	Special considerations in the purification of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): effects of protease inhibitors on rat hepatic SAT-1 activity.	G(M3) Ganglioside	50-65	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	144-149
1628323-6	1992	GM3 ganglioside also colocalized with vimentin in human fibroblasts.	G(M3) Ganglioside	0-15	vimentin	Homo sapiens	38-46
1999428-0	1991	Purification to apparent homogeneity by immunoaffinity chromatography and partial characterization of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1), from rat liver Golgi.	G(M3) Ganglioside	106-121	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	154-198
1999428-0	1991	Purification to apparent homogeneity by immunoaffinity chromatography and partial characterization of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2,3-sialyltransferase (SAT-1), from rat liver Golgi.	G(M3) Ganglioside	106-121	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	200-205
1999428-6	1991	SAT-1 specifically catalyzes the transfer of N-acetylneuraminic acid (NeuAc, sialic acid) to lactosylceramide (Gal beta 1-4Glc beta 1-O-ceramide), forming GM3 ganglioside.	G(M3) Ganglioside	155-170	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	0-5
1998515-0	1991	Special considerations in the purification of the GM3 ganglioside-forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): effects of protease inhibitors on rat hepatic SAT-1 activity.	G(M3) Ganglioside	50-65	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	198-203
2222467-0	1990	Special considerations in the purification of the GM3 ganglioside forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): solubilization of SAT-1 with lauryldimethylamine oxide.	G(M3) Ganglioside	50-65	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	144-149
2222467-0	1990	Special considerations in the purification of the GM3 ganglioside forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1): solubilization of SAT-1 with lauryldimethylamine oxide.	G(M3) Ganglioside	50-65	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	170-175
2222467-1	1990	Lauryldimethylamine oxide (LDAO) was employed in the purification of the GM3 ganglioside forming enzyme, CMP-sialic acid:lactosylceramide alpha 2-3 sialyltransferase (SAT-1) (4).	G(M3) Ganglioside	73-88	spermidine/spermine N1-acetyl transferase 1	Rattus norvegicus	167-172
34539566-8	2021	Computational docking analysis disclosed the possible stabilizing effect of PFOA on the complex between InsR and GM3 ganglioside, previously shown to be associated with the low grade chronic inflammation-related insulin resistance.	G(M3) Ganglioside	113-128	insulin receptor	Homo sapiens	104-108
34592985-8	2021	NPC1-/- i3Neurons recapitulate cardinal cellular NPC1 pathological features including perinuclear endolysosomal storage of unesterified cholesterol, accumulation of GM2 and GM3 gangliosides, mitochondrial dysfunction, and impaired axonal lysosomal transport.	G(M3) Ganglioside	173-189	NPC intracellular cholesterol transporter 1	Homo sapiens	0-4
34539566-8	2021	Computational docking analysis disclosed the possible stabilizing effect of PFOA on the complex between InsR and GM3 ganglioside, previously shown to be associated with the low grade chronic inflammation-related insulin resistance.	G(M3) Ganglioside	113-128	insulin	Homo sapiens	212-219
7291729-7	1981	Inhibition of beta-hexosaminidase and GM3-sialidase may explain the accumulation of GM2 and GM3 gangliosides in the brains of rats treated intracerebrally with suramin (Constantopoulos et al, 1980).	G(M3) Ganglioside	92-108	O-GlcNAcase	Rattus norvegicus	14-33
35228371-0	2022	(Homeostatic and Pathophysiological Regulation of Toll-like Receptor 4 Signaling by GM3 Ganglioside Molecular Species).	G(M3) Ganglioside	84-99	toll like receptor 4	Homo sapiens	50-70
3768140-9	1986	The presence of a sialate O-acetylesterase acting on hematoside containing N-glycoloyl-4-O-acetylneuraminic acid was established.	G(M3) Ganglioside	53-63	sialic acid acetylesterase	Homo sapiens	18-42
7451473-4	1981	The incubation of platelets with thrombin resulted in a 50% reduction in the labeling of both trihexosylceramide and globoside and a 100% increase in labeling of hematoside on the platelet surface.	G(M3) Ganglioside	162-172	coagulation factor II, thrombin	Homo sapiens	33-41
991384-4	1976	It could be demonstrated that N-acetyl neuraminic acid residue of the total hematoside present in the virion is hydrolyzed by neuraminidase leaving the particles fully intact.	G(M3) Ganglioside	76-86	neuraminidase 1	Homo sapiens	126-139
4701549-9	1973	Treatment of platelets with trypsin, chymotrypsin, or thrombin increased the yield of hematoside as compared with a control, while the level of ceramides was not changed.	G(M3) Ganglioside	86-96	coagulation factor II, thrombin	Homo sapiens	54-62
1141384-4	1975	Butyrate (5 mM) induces the sialyltransferase after a 4-h lag, producing maximum specific activity by 24 h. The amount of sialyl-lactosylceramide, the glycolipid product of the enzyme, increases during that time 3.5 times more than in control cultures.	G(M3) Ganglioside	122-145	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	28-45
33933428-0	2021	FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers.	G(M3) Ganglioside	82-97	epidermal growth factor receptor	Homo sapiens	65-77
28001010-9	2017	In contrast, GM3 gangliosides, several ceramides, a triacylglycerol potentially containing arachidonate, and cholesteryl palmitate were downregulated by LBP KD.	G(M3) Ganglioside	13-29	lipopolysaccharide binding protein	Homo sapiens	153-156
28974375-1	2018	Tay-Sachs disease is a severe lysosomal storage disorder caused by mutations in Hexa, the gene that encodes for the alpha subunit of lysosomal beta-hexosaminidase A (HEXA), which converts GM2 to GM3 ganglioside.	G(M3) Ganglioside	195-210	hexosaminidase A	Mus musculus	80-84
28974375-1	2018	Tay-Sachs disease is a severe lysosomal storage disorder caused by mutations in Hexa, the gene that encodes for the alpha subunit of lysosomal beta-hexosaminidase A (HEXA), which converts GM2 to GM3 ganglioside.	G(M3) Ganglioside	195-210	hexosaminidase A	Mus musculus	166-170
33864399-4	2021	Mice that express only GM3 ganglioside (double knockout produced by crossing GalNAc-T-/- and GD3 synthase-/- mice, Dbl KO) display markedly accelerated neurodegeneration with reduced survival.	G(M3) Ganglioside	23-38	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	93-105
33864399-4	2021	Mice that express only GM3 ganglioside (double knockout produced by crossing GalNAc-T-/- and GD3 synthase-/- mice, Dbl KO) display markedly accelerated neurodegeneration with reduced survival.	G(M3) Ganglioside	23-38	mcf.2 transforming sequence	Mus musculus	115-118
29196263-8	2018	Here, we confirm hypoxia-induced expression of the NeuGc GM3 ganglioside also in HeLa cells and reveal several candidate proteins, in particular GM3 synthase and subunit B of respiratory complex II (SDHB), that may be involved in the generation of NeuGc GM3 by SILAC-based proteome analysis.	G(M3) Ganglioside	57-72	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	199-203
27172362-2	2016	It was shown for caveolin-rich adipocytes, that GM3 ganglioside binds to insulin receptor (IR), dissociates its complex with caveolin, and thus lowers IR autophosphorylation following insulin treatment.	G(M3) Ganglioside	48-63	insulin receptor	Homo sapiens	73-89
27449755-1	2016	Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described.	G(M3) Ganglioside	75-90	epidermal growth factor receptor	Homo sapiens	20-52
27449755-1	2016	Interaction between epidermal growth factor receptor (EGFR) signaling with GM3 ganglioside expression has been previously described.	G(M3) Ganglioside	75-90	epidermal growth factor receptor	Homo sapiens	54-58
27626296-2	2016	GM-3 ganglioside, a widespread GSL, affects HIV entry and infection in different ways, depending on the concentration, through its anchoring activity in lipid rafts.	G(M3) Ganglioside	0-16	cathepsin A	Homo sapiens	31-34
27172362-0	2016	Glucosylceramide synthase inhibitors D-PDMP and D-EtDO-P4 decrease the GM3 ganglioside level, differ in their effects on insulin receptor autophosphorylation but increase Akt1 kinase phosphorylation in human hepatoma HepG2 cells.	G(M3) Ganglioside	71-86	UDP-glucose ceramide glucosyltransferase	Homo sapiens	0-25
27105818-0	2016	NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.	G(M3) Ganglioside	106-121	neuraminidase 3	Homo sapiens	0-4
27105818-0	2016	NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.	G(M3) Ganglioside	106-121	epidermal growth factor receptor	Homo sapiens	83-87
27172362-2	2016	It was shown for caveolin-rich adipocytes, that GM3 ganglioside binds to insulin receptor (IR), dissociates its complex with caveolin, and thus lowers IR autophosphorylation following insulin treatment.	G(M3) Ganglioside	48-63	insulin receptor	Homo sapiens	91-93
27172362-2	2016	It was shown for caveolin-rich adipocytes, that GM3 ganglioside binds to insulin receptor (IR), dissociates its complex with caveolin, and thus lowers IR autophosphorylation following insulin treatment.	G(M3) Ganglioside	48-63	insulin receptor	Homo sapiens	151-153
26206186-6	2015	The pretreatment with 3-O-methylsphingomyelin (a neutral sphingomyelinase inhibitor) restored sphingomyelin levels together with the lactosylceramide and GM3 ganglioside levels and prevented the ER stress and cell death caused by the alpha-glycoside.	G(M3) Ganglioside	154-169	sphingomyelin phosphodiesterase 2	Homo sapiens	49-73
25227752-10	2014	CONCLUSIONS: Associations of angiotensin IV, diphthamide, and GM3 gangliosides with CD implicate novel pathways in activating a Th1/Th17 inflammatory profile.	G(M3) Ganglioside	62-78	negative elongation factor complex member C/D	Homo sapiens	128-131
25313007-0	2015	Differential uPAR recruitment in caveolar-lipid rafts by GM1 and GM3 gangliosides regulates endothelial progenitor cells angiogenesis.	G(M3) Ganglioside	65-81	plasminogen activator, urokinase receptor	Homo sapiens	13-17
25462158-6	2015	In this study we investigated the localization of beta-hexosaminidase and beta-galactosidase glycohydrolases, both involved in step by step degradation of the GM1 to GM3 gangliosides, in lipid microdomains from the cortex of both an early and advanced TgCRND8 mouse model of Alzheimer"s disease.	G(M3) Ganglioside	166-182	O-GlcNAcase	Mus musculus	50-69
25462158-6	2015	In this study we investigated the localization of beta-hexosaminidase and beta-galactosidase glycohydrolases, both involved in step by step degradation of the GM1 to GM3 gangliosides, in lipid microdomains from the cortex of both an early and advanced TgCRND8 mouse model of Alzheimer"s disease.	G(M3) Ganglioside	166-182	coenzyme Q10A	Mus musculus	159-162
24399479-1	2014	We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides".	G(M3) Ganglioside	142-157	insulin	Homo sapiens	66-73
24399479-1	2014	We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides".	G(M3) Ganglioside	142-157	insulin receptor	Homo sapiens	121-137
22200571-1	2012	Previously, we demonstrated that an inhibitor of ganglioside biosynthesis, d-PDMP, could restore impaired insulin signaling in tumor necrosis factor alpha (TNFalpha)-treated adipocytes by blocking the increase of GM3 ganglioside.	G(M3) Ganglioside	213-228	tumor necrosis factor	Homo sapiens	127-154
24343103-3	2014	At the cellular level, deficiency in beta-glu activity leads to abnormal accumulation of glycosaminoglycans (GAGs), and secondary accumulation of GM2 and GM3 gangliosides, which have been linked to neuroinflammation.	G(M3) Ganglioside	154-170	glucuronidase beta	Canis lupus familiaris	37-45
23881911-8	2013	Intervention with miglustat in NPC1 patients was accompanied by striking alterations in plasma (reductions in GM1 and GM3 gangliosides) and cerebrospinal fluid (CSF) (increased MCs) sphingolipids.	G(M3) Ganglioside	118-134	NPC intracellular cholesterol transporter 1	Homo sapiens	31-35
22990144-4	2013	GM3 synthase catalyzes the formation of GM3 ganglioside from lactosylceramide, which is the first step in the synthesis of complex ganglioside species.	G(M3) Ganglioside	40-55	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
21978926-5	2012	beta-hexosaminidase and beta-galactosidase cleave specific beta-linked terminal residues from a wide range of glycoconjugates and in particular are involved in the stepwise degradation of GM1 to GM3 ganglioside.	G(M3) Ganglioside	195-210	O-GlcNAcase	Homo sapiens	0-19
21978926-5	2012	beta-hexosaminidase and beta-galactosidase cleave specific beta-linked terminal residues from a wide range of glycoconjugates and in particular are involved in the stepwise degradation of GM1 to GM3 ganglioside.	G(M3) Ganglioside	195-210	galactosidase beta 1	Homo sapiens	24-42
24136227-5	2013	Irrespective to the expression levels of DRs, a molecular interaction between ganglioside GM3, abundant in lymphoid cells, and DR4 was detected.	G(M3) Ganglioside	78-93	TNF receptor superfamily member 10a	Homo sapiens	127-130
22200571-1	2012	Previously, we demonstrated that an inhibitor of ganglioside biosynthesis, d-PDMP, could restore impaired insulin signaling in tumor necrosis factor alpha (TNFalpha)-treated adipocytes by blocking the increase of GM3 ganglioside.	G(M3) Ganglioside	213-228	tumor necrosis factor	Homo sapiens	156-164
21558756-0	2011	Physiopathological function of hematoside (GM3 ganglioside).	G(M3) Ganglioside	31-41	granulocyte macrophage antigen 3	Mus musculus	43-46
21550404-1	2011	There is no treatment for the progressive neurodegenerative lysosomal storage disorder mucopolysaccharidosis type IIIA (MPS IIIA), which occurs due to a deficiency of functional N-sulfoglucosamine sulfohydrolase (SGSH), with subsequent accumulation of partially-degraded heparan sulfate and secondarily-stored compounds including GM2 and GM3 gangliosides and unesterified cholesterol.	G(M3) Ganglioside	338-354	N-sulfoglucosamine sulfohydrolase	Canis lupus familiaris	213-217
21575493-9	2011	CONCLUSIONS: Exogenous ganglioside GM3 can inhibit the proliferation, promote apoptosis, and down-regulate the VEGF expression level in A549 cells.	G(M3) Ganglioside	23-38	vascular endothelial growth factor A	Homo sapiens	111-115
19951433-11	2009	In vitro incubation of these NeuGc-negative cells with NeuGc-rich mucin increased the presence of NeuGc in cell membranes for at least 48-72 h, as a component of the GM3 ganglioside.	G(M3) Ganglioside	166-181	mucin 1, cell surface associated	Bos taurus	66-71
20156584-9	2010	Altogether, although the involvement of other ganglioside species cannot be excluded, these findings sustain the ganglioside GM(3) as an essential molecule for EGFR/ErbB2 heterodimer stability and important regulator of EGFR tyrosine phosphorylation, but it is not crucial for tyrosine phosphorylation of the heterodimerization partner ErbB2.	G(M3) Ganglioside	113-130	epidermal growth factor receptor	Homo sapiens	160-164
20156584-9	2010	Altogether, although the involvement of other ganglioside species cannot be excluded, these findings sustain the ganglioside GM(3) as an essential molecule for EGFR/ErbB2 heterodimer stability and important regulator of EGFR tyrosine phosphorylation, but it is not crucial for tyrosine phosphorylation of the heterodimerization partner ErbB2.	G(M3) Ganglioside	113-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	165-170
20156584-9	2010	Altogether, although the involvement of other ganglioside species cannot be excluded, these findings sustain the ganglioside GM(3) as an essential molecule for EGFR/ErbB2 heterodimer stability and important regulator of EGFR tyrosine phosphorylation, but it is not crucial for tyrosine phosphorylation of the heterodimerization partner ErbB2.	G(M3) Ganglioside	113-130	epidermal growth factor receptor	Homo sapiens	220-224
20156584-9	2010	Altogether, although the involvement of other ganglioside species cannot be excluded, these findings sustain the ganglioside GM(3) as an essential molecule for EGFR/ErbB2 heterodimer stability and important regulator of EGFR tyrosine phosphorylation, but it is not crucial for tyrosine phosphorylation of the heterodimerization partner ErbB2.	G(M3) Ganglioside	113-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	336-341
18820643-1	2009	In chronic myeloid leukemia K562 cells, differentiation is also blocked because of low levels of ganglioside GM3, derived by the high expression of sialidase Neu3 active on GM3.	G(M3) Ganglioside	97-112	neuraminidase 3	Homo sapiens	158-162
19056848-7	2009	Histological studies and lipid analysis of brain sections indicated that the NP-C mice carrying the Rab9 transgene had dramatically reduced storage of GM(2) and GM(3) gangliosides relative to NP-C animals lacking the transgene.	G(M3) Ganglioside	161-179	RAB9, member RAS oncogene family	Mus musculus	100-104
18828994-1	2008	EGF-induced activation of EGFR tyrosine kinase is known to be inhibited by ganglioside GM3, its dimer, and other mimetics.	G(M3) Ganglioside	75-90	epidermal growth factor receptor	Homo sapiens	26-30
18310617-0	2008	Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4+CD25- effector and naturally occurring CD4+CD25+ regulatory T cells function.	G(M3) Ganglioside	79-94	CD4 molecule	Homo sapiens	98-101
18310617-0	2008	Differential influence of the tumour-specific non-human sialic acid containing GM3 ganglioside on CD4+CD25- effector and naturally occurring CD4+CD25+ regulatory T cells function.	G(M3) Ganglioside	79-94	interleukin 2 receptor subunit alpha	Homo sapiens	102-106
15939439-9	2005	These results provide a pathophysiological link between mesangial cell proliferation and ganglioside GM3 expression, indicating that exogenously added ganglioside GM3 inhibits the high-ambient glucose- and TGF-beta1-induced proliferation of cultured GMCs.	G(M3) Ganglioside	89-104	transforming growth factor, beta 1	Rattus norvegicus	206-215
17577665-2	2008	The gangliosideGM3, is a non-specific inhibitor of EGF receptor autophosphorylation (EGFR-phos).	G(M3) Ganglioside	4-18	epidermal growth factor receptor	Rattus norvegicus	85-89
17142315-2	2006	Ligand-dependent activation of EGFR tyrosine kinase is known to be inhibited by ganglioside GM3, but to a much lesser degree by other glycosphingolipids.	G(M3) Ganglioside	80-95	epidermal growth factor receptor	Homo sapiens	31-35
16574813-6	2006	Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.	G(M3) Ganglioside	14-29	choline kinase alpha	Homo sapiens	53-56
16574813-6	2006	Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.	G(M3) Ganglioside	14-29	interferon alpha inducible protein 27	Homo sapiens	57-60
16574813-6	2006	Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.	G(M3) Ganglioside	14-29	cyclin dependent kinase inhibitor 1B	Homo sapiens	61-65
16574813-6	2006	Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.	G(M3) Ganglioside	14-29	phosphatase and tensin homolog	Homo sapiens	79-83
16574813-6	2006	Additionally, ganglioside GM3 enhances expression of CKI p27(kip1) through the PTEN-mediated inhibition of the PI-3K/AKT signaling.	G(M3) Ganglioside	14-29	AKT serine/threonine kinase 1	Homo sapiens	117-120
16538029-5	2006	Following treatment with RANKL, ganglioside GM3 and GM1 were increased in the treated bone marrow cells, whereas other types were not detected using thin layer chromatography analysis.	G(M3) Ganglioside	32-47	TNF superfamily member 11	Homo sapiens	25-30
15939439-0	2005	Ganglioside GM3 inhibits the high glucose- and TGF-beta1-induced proliferation of rat glomerular mesangial cells.	G(M3) Ganglioside	0-15	transforming growth factor, beta 1	Rattus norvegicus	47-56
16208470-0	2006	Role of tumour-associated N-glycolylated variant of GM3 ganglioside in cancer progression: effect over CD4 expression on T cells.	G(M3) Ganglioside	52-67	CD4 molecule	Homo sapiens	103-106
11447130-0	2001	Epidermal growth factor receptor glycosylation is required for ganglioside GM3 binding and GM3-mediated suppression [correction of suppresion] of activation.	G(M3) Ganglioside	63-78	Epidermal growth factor receptor	Drosophila melanogaster	0-32
12641744-6	2003	Remarkably, TAG-1 was cross-linked in a similar extent by the photoactivated ganglioside GM3, GM1 and GD1b.	G(M3) Ganglioside	77-92	contactin 2	Homo sapiens	12-17
12068006-0	2002	Tetraspanin CD9 is a "proteolipid," and its interaction with alpha 3 integrin in microdomain is promoted by GM3 ganglioside, leading to inhibition of laminin-5-dependent cell motility.	G(M3) Ganglioside	108-123	CD9 antigen	Cricetulus griseus	12-15
12068006-1	2002	GM3 ganglioside inhibits tetraspanin CD9-facilitated cell motility in various cell lines (Ono, M., Handa, K., Sonnino, S., Withers, D. A., Nagai, H., and Hakomori, S. (2001) Biochemistry 40, 6414-6421).	G(M3) Ganglioside	0-15	CD9 antigen	Cricetulus griseus	37-40
12145192-3	2002	The aim of the study was to analyze the mode of action of the lactone of the ganglioside GM3 on epidermal growth factor (EGF) signaling in human ovarial epidermoid carcinoma A431 cells and cell growth in human oral epidermoid carcinoma KB cells by applying the GM3 lactone analog HK1-ceramide 2, which is stable under hydrolytic conditions.	G(M3) Ganglioside	77-92	hexokinase 1	Homo sapiens	280-283
11707432-2	2002	We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase activity and its mRNA.	G(M3) Ganglioside	139-154	tumor necrosis factor	Rattus norvegicus	49-76
11707432-2	2002	We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase activity and its mRNA.	G(M3) Ganglioside	139-154	tumor necrosis factor	Rattus norvegicus	78-87
11707432-2	2002	We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase activity and its mRNA.	G(M3) Ganglioside	139-154	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	186-198
11591370-4	2001	These findings reveal that gp120 binding induces a strict association between CXCR4 and ganglioside GM3, supporting the view that GM3 and CXCR4 are components of a functional multimolecular complex critical for HIV-1 entry.	G(M3) Ganglioside	88-103	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	27-32
11591370-4	2001	These findings reveal that gp120 binding induces a strict association between CXCR4 and ganglioside GM3, supporting the view that GM3 and CXCR4 are components of a functional multimolecular complex critical for HIV-1 entry.	G(M3) Ganglioside	88-103	C-X-C motif chemokine receptor 4	Homo sapiens	78-83
11591370-4	2001	These findings reveal that gp120 binding induces a strict association between CXCR4 and ganglioside GM3, supporting the view that GM3 and CXCR4 are components of a functional multimolecular complex critical for HIV-1 entry.	G(M3) Ganglioside	88-103	C-X-C motif chemokine receptor 4	Homo sapiens	138-143
15385432-6	2005	On the other hand, although ganglioside GM3 was shown to be able to induce the differentiation of HL-60 cells into the monocyte/macrophage lineage, effect of ganglioside GM3 on expression of CD11b as a differentiation marker in HL-60 cells has been not reported yet.	G(M3) Ganglioside	158-173	integrin subunit alpha M	Homo sapiens	191-196
12032173-0	2002	Ganglioside GM3 activates ERKs in human lymphocytic cells.	G(M3) Ganglioside	0-15	mitogen-activated protein kinase 1	Homo sapiens	26-30
11201791-6	2000	Using this approach, we identified globotriaosylceramide (Gb3) and ganglioside GM3 as the main lymphocyte GSL recognized by gp120.	G(M3) Ganglioside	67-82	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	124-129
11371204-0	2001	GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy.	G(M3) Ganglioside	0-15	CD9 antigen	Cricetulus griseus	25-28
11371204-0	2001	GM3 ganglioside inhibits CD9-facilitated haptotactic cell motility: coexpression of GM3 and CD9 is essential in the downregulation of tumor cell motility and malignancy.	G(M3) Ganglioside	0-15	CD9 antigen	Cricetulus griseus	92-95
11440194-0	2001	Coupling of nerve growth factor to its receptor: inhibition by anti-GM3 ganglioside antibody.	G(M3) Ganglioside	68-83	nerve growth factor	Rattus norvegicus	12-31
11440194-4	2001	An antibody against GM3 ganglioside was found to inhibit the nerve growth factor mediated neurite formation of both the cells in vitro significantly.	G(M3) Ganglioside	20-35	nerve growth factor	Rattus norvegicus	61-80
10428836-7	1999	The mitochondrial effects of GD3 ganglioside are selective, in that they cannot be mimicked by either GD1a or GM3 gangliosides, and they are fully sensitive to cyclosporin A, which inhibits both the mitochondrial permeability transition in situ and the onset of apoptosis induced by GD3 ganglioside.	G(M3) Ganglioside	110-126	GRDX	Homo sapiens	29-32
10527410-4	1999	Fibrinogen interacted minimally with phosphatidylinositol, and not at all with pure phosphatidylcholine (PC) or PC vesicles containing 5% glycosphingolipid (lactosylceramide, ganglioside GM3, ganglioside GD3).	G(M3) Ganglioside	175-190	fibrinogen beta chain	Homo sapiens	0-10
10233996-3	1999	We identified globotriaosylceramide (Gb3) and ganglioside GM3 as the main glycosphingolipids recognized by gp120.	G(M3) Ganglioside	46-61	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	107-112
9600078-0	1998	Sequential interaction of CD4 and HIV-1 gp120 with a reconstituted membrane patch of ganglioside GM3: implications for the role of glycolipids as potential HIV-1 fusion cofactors.	G(M3) Ganglioside	85-100	CD4 molecule	Homo sapiens	26-29
9600078-0	1998	Sequential interaction of CD4 and HIV-1 gp120 with a reconstituted membrane patch of ganglioside GM3: implications for the role of glycolipids as potential HIV-1 fusion cofactors.	G(M3) Ganglioside	85-100	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	40-45
8840162-0	1996	Differential modulation of basic fibroblast and epidermal growth factor receptor activation by ganglioside GM3 in cultured retinal Muller glia.	G(M3) Ganglioside	95-110	epidermal growth factor receptor	Homo sapiens	48-80
8840162-3	1996	These glial cells readily incorporated exogenously administered GM3 ganglioside, which was not substantially metabolized within 24 h. Such treatments significantly inhibited bFGF-induced DNA replication and cell migration, while having much less effect on analogous EGF-mediated behaviors.	G(M3) Ganglioside	64-79	fibroblast growth factor 2	Homo sapiens	174-178