PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26774329-5	2016	We demonstrated that recombinant Ymt was as toxic to mice as the native protein when administered via the intraperitoneal or intravenous route, and inhibited the elevation of blood sugar caused by adrenaline.	Epinephrine	197-207	toxin protein	Yersinia pestis	33-36
27068752-0	2016	Enhanced activity of hormone sensitive lipase (HSL) in mesenteric but not epididymal fat correlates with higher production of epinephrine in mesenteric adipocytes in rat model of cachectic rheumatoid arthritis.	Epinephrine	126-137	lipase E, hormone sensitive type	Rattus norvegicus	47-50
27059942-7	2016	Similarly, the cAMP-increasing agent adrenaline also enhanced the sensitivity of RAW264.7 macrophages to LPS as demonstrated by IL-33 production.	Epinephrine	37-47	interleukin 33	Homo sapiens	128-133
27059942-8	2016	The protein kinase A (PKA) inhibitor H89 blocked the effects of 8-Br-cAMP and adrenaline on IL-33 production, suggesting that PKA is involved in IL-33 induction.	Epinephrine	78-88	interleukin 33	Homo sapiens	92-97
27059942-8	2016	The protein kinase A (PKA) inhibitor H89 blocked the effects of 8-Br-cAMP and adrenaline on IL-33 production, suggesting that PKA is involved in IL-33 induction.	Epinephrine	78-88	interleukin 33	Homo sapiens	145-150
27059942-10	2016	Our findings suggest that stress events and the subsequent secretion of adrenaline enhance macrophage production via IL-33; this process may be associated with the pathogenesis of various disorders involving IL-33.	Epinephrine	72-82	interleukin 33	Homo sapiens	117-122
27059942-10	2016	Our findings suggest that stress events and the subsequent secretion of adrenaline enhance macrophage production via IL-33; this process may be associated with the pathogenesis of various disorders involving IL-33.	Epinephrine	72-82	interleukin 33	Homo sapiens	208-213
27312548-10	2016	In a conclusion, there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.	Epinephrine	154-165	purinergic receptor P2X 3	Homo sapiens	76-80
27312548-10	2016	In a conclusion, there is a relationship between the elevated expression of P2X3 receptor and P2X7 receptor in peripheral blood leukocytes and high serum epinephrine and norepinephrine levels in hyperthyroidism patients.	Epinephrine	154-165	purinergic receptor P2X 7	Homo sapiens	94-107
26896587-5	2016	Adrenaline is particularly important for counter-regulation in individuals with type 1 (insulin-dependent) diabetes because these patients do not produce endogenous insulin and also lose their ability to secrete glucagon soon after diagnosis.	Epinephrine	0-10	insulin	Homo sapiens	88-95
26572541-1	2016	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of catecholamines and TH immunoreactivity is indicative of cells synthesising either adrenaline/noradrenaline or dopamine.	Epinephrine	156-166	tyrosine hydroxylase	Danio rerio	93-95
27224648-9	2016	A positive correlation was also found between urinary noradrenaline and adrenaline levels and LAT1 gene expression in PHEO.	Epinephrine	57-67	solute carrier family 7 member 5	Homo sapiens	94-98
27087645-4	2016	To identify the active compound of ALE, we subsequently fractionated and determined the level of beta-hexosaminidase in all subfractions.	Epinephrine	35-38	O-GlcNAcase	Rattus norvegicus	97-116
27087645-5	2016	Oleamide was identified as an active compound of ALE, which attenuated the secretion of histamine and the production of tumor necrosis factor (TNF)-alpha and interleukin-4 (IL-4) in cells treated with compound 48/80 or A23187/phorbol myristate acetate (PMA).	Epinephrine	49-52	tumor necrosis factor	Rattus norvegicus	120-153
27087645-5	2016	Oleamide was identified as an active compound of ALE, which attenuated the secretion of histamine and the production of tumor necrosis factor (TNF)-alpha and interleukin-4 (IL-4) in cells treated with compound 48/80 or A23187/phorbol myristate acetate (PMA).	Epinephrine	49-52	interleukin 4	Rattus norvegicus	158-171
27087645-5	2016	Oleamide was identified as an active compound of ALE, which attenuated the secretion of histamine and the production of tumor necrosis factor (TNF)-alpha and interleukin-4 (IL-4) in cells treated with compound 48/80 or A23187/phorbol myristate acetate (PMA).	Epinephrine	49-52	interleukin 4	Rattus norvegicus	173-177
26964897-4	2016	In primary rat hepatocytes, we found that short exposure to glucagon or adrenaline caused a rapid increase in Ser(552) phosphorylation on beta-catenin that leads to increased cyclin D1 and c-Myc expression.	Epinephrine	72-82	catenin beta 1	Rattus norvegicus	138-150
26964897-4	2016	In primary rat hepatocytes, we found that short exposure to glucagon or adrenaline caused a rapid increase in Ser(552) phosphorylation on beta-catenin that leads to increased cyclin D1 and c-Myc expression.	Epinephrine	72-82	cyclin D1	Rattus norvegicus	175-184
26964897-4	2016	In primary rat hepatocytes, we found that short exposure to glucagon or adrenaline caused a rapid increase in Ser(552) phosphorylation on beta-catenin that leads to increased cyclin D1 and c-Myc expression.	Epinephrine	72-82	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	189-194
26773046-10	2016	Heightened platelet reactivity, shortened tail-bleeding time, and reduced survival following collagen/epinephrine-induced pulmonary embolism were also observed in Dicer1-deficient animals.	Epinephrine	102-113	dicer 1, ribonuclease type III	Mus musculus	163-169
27007161-4	2016	Expression of the enzyme, phenylethanolamine N-methyltransferase (PNMT), which catalyzes the methylation of norepinephrine to epinephrine, was significantly lower in malignant PCC/PGL as compared to benign samples.	Epinephrine	111-122	phenylethanolamine N-methyltransferase	Homo sapiens	26-64
27007161-4	2016	Expression of the enzyme, phenylethanolamine N-methyltransferase (PNMT), which catalyzes the methylation of norepinephrine to epinephrine, was significantly lower in malignant PCC/PGL as compared to benign samples.	Epinephrine	111-122	phenylethanolamine N-methyltransferase	Homo sapiens	66-70
27007161-4	2016	Expression of the enzyme, phenylethanolamine N-methyltransferase (PNMT), which catalyzes the methylation of norepinephrine to epinephrine, was significantly lower in malignant PCC/PGL as compared to benign samples.	Epinephrine	111-122	crystallin gamma D	Homo sapiens	176-179
26761434-1	2016	Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis.	Epinephrine	127-137	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
26761434-1	2016	Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway responsible for adrenaline biosynthesis.	Epinephrine	127-137	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
26773917-1	2016	BACKGROUND: Catechol-O-methyltransferase (COMT) is a catabolic enzyme involved in the degradation of bioactive molecules including the neurotransmitters epinephrine, norepinephrine, and dopamine.	Epinephrine	153-164	catechol-O-methyltransferase	Homo sapiens	12-40
27013684-10	2016	SIGNIFICANCE STATEMENT: We found that monozygotic twins with focal bilateral amygdala lesions report panic anxiety in response to intravenous infusions of isoproterenol, a beta-adrenergic agonist similar to adrenaline.	Epinephrine	207-217	amyloid beta precursor protein	Homo sapiens	170-176
26772612-3	2016	We have further characterized the novel beta2 adrenoceptor agonist C26 (7-[(R)-2-((1R,2R)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone), which displays higher intrinsic activity than the endogenous ligand adrenaline in cAMP accumulation, beta-arrestin-2 recruitment, and receptor internalization assays.	Epinephrine	230-240	adrenoceptor beta 2	Homo sapiens	40-58
26772612-5	2016	This was compared with 0.31 +- 0.04 and 0.34 +- 0.01 hours for adrenaline-mediated beta-arrestin-2 recruitment and GFP-beta2 internalization, respectively.	Epinephrine	63-73	arrestin beta 2	Homo sapiens	83-98
26773917-1	2016	BACKGROUND: Catechol-O-methyltransferase (COMT) is a catabolic enzyme involved in the degradation of bioactive molecules including the neurotransmitters epinephrine, norepinephrine, and dopamine.	Epinephrine	153-164	catechol-O-methyltransferase	Homo sapiens	42-46
26712698-9	2016	Finally, we demonstrated that LPO-copper phosphate HNFs can be utilized as a nanosensor for detection of dopamine and epinephrine.	Epinephrine	118-129	lactoperoxidase	Bos taurus	30-33
26467632-7	2016	Epinephrine treatment abolished the genotype differences in glucose tolerance and rGLUT2 levels, suggesting that reduced renal sympathetic nervous system (SNS) activity is the underlying mechanism for the observed glycosuria and improved glucose tolerance in ArcPOMC-deficient mice.	Epinephrine	0-11	solute carrier family 2 member 2	Rattus norvegicus	82-88
26895752-7	2016	Moreover, epinephrine induced a selective mobilization of IL-6-sensitive NK cells, and IL-6-blocking antibodies blunted training-induced tumor suppression, intratumoral NK cell infiltration, and NK cell activation.	Epinephrine	10-21	interleukin 6	Mus musculus	58-62
26572539-4	2016	Adrenomedullary content of the secreted adrenal catecholamines norepinephrine (NE) and epinephrine (EPI) was decreased 30-40 % in Chga-KO mice.	Epinephrine	66-77	chromogranin A	Mus musculus	130-134
26572539-4	2016	Adrenomedullary content of the secreted adrenal catecholamines norepinephrine (NE) and epinephrine (EPI) was decreased 30-40 % in Chga-KO mice.	Epinephrine	100-103	chromogranin A	Mus musculus	130-134
26908391-5	2016	Administration of the highest dose of Ang II (0.07 nmol per rat, icv) but not lower doses (0.01 and 0.02 nmol per rat, icv) elevated the plasma concentration of adrenaline.	Epinephrine	161-171	angiotensinogen	Rattus norvegicus	38-44
26661222-6	2016	The increased uptake of phosphorylated human beta-glucuronidase was inhibited by mannose 6-phosphate for the agents (+-)epinephrine and retinoic acid and by L-NG-nitroarginine methyl ester for the agent lipopolysaccharide in neonatal and adult mice.	Epinephrine	116-131	glucuronidase beta	Homo sapiens	45-63
26908391-6	2016	Bilateral adrenalectomy reduced Ang II-induced elevation in adrenaline, but had no effect on the Ang II-induced shortening of the intercontraction interval.	Epinephrine	60-70	angiotensinogen	Rattus norvegicus	32-38
26872389-3	2016	IL-6 regulation was tested in C2C12 myotubes and in soleus during treatment with epinephrine (EPI) or LPS.	Epinephrine	81-92	interleukin 6	Mus musculus	0-4
26465218-1	2016	OBJECTIVES: To test the hypothesis that nebulized epinephrine ameliorates pulmonary dysfunction by dual action-bronchodilation (beta2-adrenergic receptor agonism) and attenuation of airway hyperemia (alpha1-adrenergic receptor agonism) with minimal systemic effects.	Epinephrine	50-61	beta-2 adrenergic receptor	Ovis aries	128-153
27356717-2	2016	In BCa, several studies have linked beta2-adrenergic receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation.	Epinephrine	134-145	adrenoceptor beta 2	Homo sapiens	36-61
26519038-2	2016	Previously, our group performed a genome-wide association study of platelet reactivity identifying single nucleotide polymorphisms (SNPs) associated with ADP- and epinephrine- induced aggregation, including SNPs in MRVI1, PIK3CG, JMJD1C, and PEAR1, among others.	Epinephrine	163-174	inositol 1,4,5-triphosphate receptor associated 1	Homo sapiens	215-220
26519038-2	2016	Previously, our group performed a genome-wide association study of platelet reactivity identifying single nucleotide polymorphisms (SNPs) associated with ADP- and epinephrine- induced aggregation, including SNPs in MRVI1, PIK3CG, JMJD1C, and PEAR1, among others.	Epinephrine	163-174	jumonji domain containing 1C	Homo sapiens	230-236
26519038-2	2016	Previously, our group performed a genome-wide association study of platelet reactivity identifying single nucleotide polymorphisms (SNPs) associated with ADP- and epinephrine- induced aggregation, including SNPs in MRVI1, PIK3CG, JMJD1C, and PEAR1, among others.	Epinephrine	163-174	platelet endothelial aggregation receptor 1	Homo sapiens	242-247
26566905-7	2016	Furthermore, immunocytochemistry experiments and measurements of apical CFTR expression by Western blot analysis of biotinylated membranes revealed a decrease in the level of CFTR protein in monolayers treated with carvedilol but no significant change in monolayers treated with epinephrine.	Epinephrine	279-290	CF transmembrane conductance regulator	Homo sapiens	175-179
26808480-5	2016	IL-6 infused with epinephrine caused no synergenic increase in HGO.	Epinephrine	18-29	interleukin 6	Rattus norvegicus	0-4
26653571-3	2016	Orexin neurons in the perifornical hypothalamus (PeH) project to the rostral ventrolateral medulla (RVLM) and are likely to be involved in epinephrine secretion during hypoglycemia.	Epinephrine	139-150	hypocretin neuropeptide precursor	Homo sapiens	0-6
26653571-7	2016	These results suggest that activation of orexin PeH-RVLM neurons and orexin type 2 receptors in the RVLM facilitates epinephrine release by increasing sympathetic drive to adrenal chromaffin cells during hypoglycemia.	Epinephrine	117-128	hypocretin neuropeptide precursor	Homo sapiens	41-47
26653571-7	2016	These results suggest that activation of orexin PeH-RVLM neurons and orexin type 2 receptors in the RVLM facilitates epinephrine release by increasing sympathetic drive to adrenal chromaffin cells during hypoglycemia.	Epinephrine	117-128	hypocretin neuropeptide precursor	Rattus norvegicus	69-75
26790973-9	2016	In contrast, early postoperative parameters revealed a higher correlation with the occurrence of mesenteric ischemia including the use of norepinephrine (OR 3.5 CI95% 1.6-7.8), epinephrine (OR 2.0, CI95% 1.1-3.7), and serum lactate levels >3 mmol/L (OR 2.9, CI95% 1.5-5.6).	Epinephrine	141-152	olfactory receptor family 5 subfamily H member 4 pseudogene	Homo sapiens	154-160
26491049-9	2015	Confocal images of the basal membrane of Calu-3 cells labeled with anti-beta1-integrin (clone HUTS-4) antibody showed that treatment with epinephrine or carvedilol reduced the level of activated integrin in the membrane.	Epinephrine	138-149	integrin subunit beta 1	Homo sapiens	72-86
26612065-3	2016	In the present study, the effect of the stress-related catecholamine adrenaline on the expression of TGF-beta isoforms in RAW264.7 macrophages and murine bone marrow-derived macrophages was examined.	Epinephrine	69-79	transforming growth factor, beta 1	Mus musculus	101-109
26612065-4	2016	Treatment with adrenaline markedly increased the mRNA expression of TGF-beta3 but not of TGF-beta1 and -beta2.	Epinephrine	15-25	transforming growth factor, beta 3	Mus musculus	68-77
26612065-5	2016	Agonist and antagonist studies indicated that adrenaline-induced TGF-beta3 mRNA expression is mediated via beta2 -adrenoceptor.	Epinephrine	46-56	transforming growth factor, beta 3	Mus musculus	65-74
26612065-5	2016	Agonist and antagonist studies indicated that adrenaline-induced TGF-beta3 mRNA expression is mediated via beta2 -adrenoceptor.	Epinephrine	46-56	adrenergic receptor, beta 2	Mus musculus	107-126
26083800-7	2016	Flow cytometric analysis of platelets after stimulated with 1 muM epinephrine showed that glycoprotein (GP) IIb/IIIa and P-selectin expression of epinephrine good- and impaired-responders were 27.1 +- 11.0% vs. 9.9 +- 5.4% (p = 0.003) and 12.2 +- 6.2% vs. 3.6 +- 3.5% (p < 0.001), respectively.	Epinephrine	66-77	selectin P	Homo sapiens	121-131
26083800-7	2016	Flow cytometric analysis of platelets after stimulated with 1 muM epinephrine showed that glycoprotein (GP) IIb/IIIa and P-selectin expression of epinephrine good- and impaired-responders were 27.1 +- 11.0% vs. 9.9 +- 5.4% (p = 0.003) and 12.2 +- 6.2% vs. 3.6 +- 3.5% (p < 0.001), respectively.	Epinephrine	146-157	selectin P	Homo sapiens	121-131
26506851-5	2015	During acute hypoglycemia, leptin decreased glucagon responses by 51% but increased epinephrine and norepinephrine by 24 and 48%, respectively.	Epinephrine	84-95	leptin	Rattus norvegicus	27-33
26506851-7	2015	Subsequent brain leptin infusion during hypoglycemia paradoxically increased glucagon by 45% as well as epinephrine by 19%.	Epinephrine	104-115	leptin	Rattus norvegicus	17-23
26506851-8	2015	In conclusion, leptin acts within the brain to diminish glucagon secretion during acute hypoglycemia but increases epinephrine, potentially limiting its detrimental effects during hypoglycemia.	Epinephrine	115-126	leptin	Rattus norvegicus	15-21
26506851-9	2015	Exposure to recurrent hypoglycemia markedly suppresses plasma leptin, whereas exogenous brain leptin delivery enhances both glucagon and epinephrine release to subsequent hypoglycemia.	Epinephrine	137-148	leptin	Rattus norvegicus	94-100
26282245-10	2016	CONCLUSION: We identified an SCN5A mutation in a patient with sinus node dysfunction and epinephrine-induced QT prolongation, which was an atypical phenotype for LQT3.	Epinephrine	89-100	sodium voltage-gated channel alpha subunit 5	Homo sapiens	29-34
27102784-9	2016	Caspase 3 activity was also increased in epinephrine treated cells.	Epinephrine	41-52	caspase 3	Canis lupus familiaris	0-9
27647952-10	2016	In addition, ALE inhibited expression of COX-2 and iNOS and production of NO and PGE2 in Raw 264.7 cells.	Epinephrine	13-16	prostaglandin-endoperoxide synthase 2	Mus musculus	41-46
27647952-10	2016	In addition, ALE inhibited expression of COX-2 and iNOS and production of NO and PGE2 in Raw 264.7 cells.	Epinephrine	13-16	nitric oxide synthase 2, inducible	Mus musculus	51-55
26398936-8	2015	Alk1(+/-) mice showed a greater hypotensive response to the beta-adrenergic antagonist atenolol and higher concentrations of epinephrine and norepinephrine in plasma than Alk1(+/+) mice.	Epinephrine	125-136	activin A receptor, type II-like 1	Mus musculus	0-4
26088878-6	2015	In the current study, epinephrine increased the number of cancer stem cell like cells (CSCs) from three NSCLC cell lines in spheroid formation assays while enhancing intracellular cAMP and the stem cell markers sonic hedgehog (SHH), aldehyde dehydrogenase-1 (ALDH-1) and Gli1, effects reversed by GABA or dynorphin B via Galphai -mediated inhibition of cAMP formation.	Epinephrine	22-33	sonic hedgehog	Mus musculus	227-230
26088878-6	2015	In the current study, epinephrine increased the number of cancer stem cell like cells (CSCs) from three NSCLC cell lines in spheroid formation assays while enhancing intracellular cAMP and the stem cell markers sonic hedgehog (SHH), aldehyde dehydrogenase-1 (ALDH-1) and Gli1, effects reversed by GABA or dynorphin B via Galphai -mediated inhibition of cAMP formation.	Epinephrine	22-33	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	233-257
26088878-6	2015	In the current study, epinephrine increased the number of cancer stem cell like cells (CSCs) from three NSCLC cell lines in spheroid formation assays while enhancing intracellular cAMP and the stem cell markers sonic hedgehog (SHH), aldehyde dehydrogenase-1 (ALDH-1) and Gli1, effects reversed by GABA or dynorphin B via Galphai -mediated inhibition of cAMP formation.	Epinephrine	22-33	aldehyde dehydrogenase family 1, subfamily A1	Mus musculus	259-265
26088878-6	2015	In the current study, epinephrine increased the number of cancer stem cell like cells (CSCs) from three NSCLC cell lines in spheroid formation assays while enhancing intracellular cAMP and the stem cell markers sonic hedgehog (SHH), aldehyde dehydrogenase-1 (ALDH-1) and Gli1, effects reversed by GABA or dynorphin B via Galphai -mediated inhibition of cAMP formation.	Epinephrine	22-33	GLI-Kruppel family member GLI1	Mus musculus	271-275
26417114-3	2015	We observed that glucose, insulin, glucagon and adrenaline differentially modulate the intracellular distribution of aldolase B and FBPase-1.	Epinephrine	48-58	fructose-bisphosphatase 1	Homo sapiens	132-140
26858830-7	2015	Patients who were homozygous for the mutant PlA2 allele had an increased aggregatory response to adenosine diphosphate, collagen, adrenaline, ristocetin, thrombin receptor-activating peptide 6 and U46619, when assessed using agonist-concentration response curves.	Epinephrine	130-140	phospholipase A2 group IB	Homo sapiens	44-48
26243176-4	2015	Systemic or blood-wide platelet activation (SPA) induced by epinephrine has been shown to be an in vivo feature of HTN, and serotonin and thromboxane A2, two vasoconstrictors released by activated platelets, synergize in vitro with angiotensin II.	Epinephrine	60-71	surfactant protein A2	Homo sapiens	44-47
26475702-2	2015	The aim of the current study was to examine the impact of prenatal GC exposure on the postnatal regulation of the gene encoding for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the biosynthesis of the catecholamine, epinephrine.	Epinephrine	241-252	phenylethanolamine-N-methyltransferase	Rattus norvegicus	132-170
26475702-2	2015	The aim of the current study was to examine the impact of prenatal GC exposure on the postnatal regulation of the gene encoding for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the biosynthesis of the catecholamine, epinephrine.	Epinephrine	241-252	phenylethanolamine-N-methyltransferase	Rattus norvegicus	172-176
26243176-9	2015	Epinephrine release causes SPA.	Epinephrine	0-11	surfactant protein A2	Homo sapiens	27-30
25732373-0	2015	Sublingual Diffusion of Epinephrine Microcrystals from Rapidly Disintegrating Tablets for the Potential First-Aid Treatment of Anaphylaxis: In Vitro and Ex Vivo Study.	Epinephrine	24-35	activation induced cytidine deaminase	Homo sapiens	110-113
26514659-5	2015	We also studied colocalization of neuropeptide Y (NPY) in norepinephrine and epinephrine-containing neurons as NPY is a common cotransmitter with central and peripheral catecholamines.	Epinephrine	61-72	neuropeptide Y	Rattus norvegicus	34-48
26514659-5	2015	We also studied colocalization of neuropeptide Y (NPY) in norepinephrine and epinephrine-containing neurons as NPY is a common cotransmitter with central and peripheral catecholamines.	Epinephrine	61-72	neuropeptide Y	Rattus norvegicus	50-53
26514659-6	2015	We found significantly increased expression and coexpression of NPY in norepinephrine and epinephrine-positive neurons of locus coeruleus in SHR compared with Wistar rats.	Epinephrine	74-85	neuropeptide Y	Rattus norvegicus	64-67
26512958-0	2015	A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy.	Epinephrine	100-111	microRNA 371a	Homo sapiens	8-16
26512958-0	2015	A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy.	Epinephrine	100-111	BAG cochaperone 3	Homo sapiens	49-53
25732373-1	2015	For the first-aid treatment of anaphylaxis, epinephrine (Epi) 0.3 mg intramuscular (IM) injection in the thigh is the drug of choice.	Epinephrine	44-55	activation induced cytidine deaminase	Homo sapiens	14-17
25732373-1	2015	For the first-aid treatment of anaphylaxis, epinephrine (Epi) 0.3 mg intramuscular (IM) injection in the thigh is the drug of choice.	Epinephrine	57-60	activation induced cytidine deaminase	Homo sapiens	14-17
26211486-1	2015	BACKGROUND AND PURPOSE: Our previous studies have shown the beta2 -adrenoceptor and its endogenous ligand, adrenaline, are required for development of the asthma phenotype in murine asthma models.	Epinephrine	107-117	adrenergic receptor, beta 2	Mus musculus	60-79
26130763-5	2015	The shRNA reduced VMH SGLT1 expression by 53% in nondiabetic rats, and this augmented glucagon and epinephrine responses and hepatic glucose production during hypoglycemia.	Epinephrine	99-110	solute carrier family 5 member 1	Rattus norvegicus	22-27
26130763-6	2015	Similarly, SGLT1 knockdown improved the glucagon and epinephrine responses in RH rats and restored the impaired epinephrine response to hypoglycemia in STZ-diabetic animals.	Epinephrine	53-64	solute carrier family 5 member 1	Rattus norvegicus	11-16
26130763-6	2015	Similarly, SGLT1 knockdown improved the glucagon and epinephrine responses in RH rats and restored the impaired epinephrine response to hypoglycemia in STZ-diabetic animals.	Epinephrine	112-123	solute carrier family 5 member 1	Rattus norvegicus	11-16
26032882-0	2015	Using adrenaline during neonatal resuscitation may have an impact on serum cardiac troponin-T levels.	Epinephrine	6-16	troponin T2, cardiac type	Homo sapiens	75-93
26173457-7	2015	Within the adrenal medulla, pendrin localizes to both epinephrine- and norepinephrine-producing chromaffin cells.	Epinephrine	54-65	solute carrier family 26, member 4	Mus musculus	28-35
26173457-11	2015	With 20 min of immobilization stress, epinephrine and norepinephrine concentrations increased more in pendrin-null than in wild-type mice, although stress produced a similar increase in blood pressure in both groups.	Epinephrine	38-49	solute carrier family 26, member 4	Mus musculus	102-109
26207649-7	2015	In vitro experiments demonstrated not only that (a)-COMT is catalytically active but also that it displays unique substrate specificity, exhibiting enzymatic activity with dopamine but not epinephrine.	Epinephrine	189-200	catechol-O-methyltransferase	Homo sapiens	52-56
26003139-6	2015	In vitro experiments revealed an adrenaline-induced alpha1-ADR-mediated decrease in Nur77 transcription in Leydig cells.	Epinephrine	33-43	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	84-89
26003139-7	2015	Adrenaline-induced increase of repressor Dax1 also involves ADRs in Leydig cells.	Epinephrine	0-10	nuclear receptor subfamily 0, group B, member 1	Rattus norvegicus	41-45
26032882-2	2015	We evaluated whether cTnT was better correlated with adrenaline during cardiopulmonary resuscitation (CPR) than with the severity of the insult itself, based on the Apgar scores.	Epinephrine	53-63	troponin T2, cardiac type	Homo sapiens	21-25
26032882-7	2015	Multiple regression analysis showed significantly higher cTnT values in the CPR plus adrenaline group, but no significant relationship between cTnT and the Apgar scores.	Epinephrine	85-95	troponin T2, cardiac type	Homo sapiens	57-61
26321956-4	2015	In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation.	Epinephrine	22-32	integrin subunit alpha M	Homo sapiens	70-75
25517250-7	2015	Results Our results showed that G-CSF have no direct effect on CXCR4 expression on human CD34+ cells in vitro and treating HSCs with epinephrine leads to significantly increased CXCR4 in 1, 3, and 5 hours.	Epinephrine	133-144	C-X-C motif chemokine receptor 4	Homo sapiens	178-183
26346727-4	2015	COMT has an important role in regulating the embryonic levels of catecholamine neurotransmitters (such as dopamine, norepinephrine, and epinephrine) and estrogens.	Epinephrine	119-130	catechol-O-methyltransferase	Homo sapiens	0-4
26330755-4	2015	Both microinjection of glutamate receptor agonists (NMDA and AMPA) into the MVN or rostral ventrolateral medullary nucleus (RVLM) and SNP-induced hypotension led to increased number of c-Fos positive neurons in the intermediolateral cell column of the middle thoracic spinal regions and increased blood epinephrine levels.	Epinephrine	303-314	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	185-190
26321956-4	2015	In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation.	Epinephrine	22-32	integrin subunit beta 2	Homo sapiens	76-80
26321956-4	2015	In human neutrophils, adrenaline and noradrenaline inhibit migration, CD11b/CD18 expression, and oxidative metabolism, possibly through beta-AR, although the role of alpha1- and alpha2-AR requires further investigation.	Epinephrine	22-32	adrenergic receptor, beta 1	Mus musculus	136-143
26440162-5	2015	Our results show that the expression of the mRNA for Sirt1 was enhanced by RSV in liver under restriction ( <= 0.0112) and by LA in muscle, more under restriction ( <= 0.0121) than after epinephrine administration ( < 0.0001).	Epinephrine	193-204	sirtuin 1	Bos taurus	53-58
25957836-3	2015	Our previous study has shown that epinephrine induces the expression of Trx-1.	Epinephrine	34-45	thioredoxin 1	Rattus norvegicus	72-77
25957836-5	2015	However, how TH is regulated by epinephrine is still unknown.	Epinephrine	32-43	tyrosine hydroxylase	Rattus norvegicus	13-15
25957836-6	2015	In the present study, we found that epinephrine increased the expression of TH in a dose- and time-dependent manner in PC12 cells, which was inhibited by propranolol (beta-adrenergic receptor inhibitor), but not by phenoxybenzamine (alpha-adrenergic receptor inhibitor).	Epinephrine	36-47	tyrosine hydroxylase	Rattus norvegicus	76-78
25957836-8	2015	More importantly, overexpression of Trx-1 significantly enhanced the expression of TH, while Trx-1 siRNA suppressed TH expression induced by epinephrine.	Epinephrine	141-152	thioredoxin 1	Rattus norvegicus	93-98
25957836-9	2015	These results suggest that Trx-1 is involved in TH expression induced by epinephrine in PC12 cells.	Epinephrine	73-84	thioredoxin 1	Rattus norvegicus	27-32
25865680-7	2015	Moreover, Gongjin-Dan considerably normalized the forced running stress-induced changes in serum corticosterone and adrenaline levels, as well as brain serotonin level.	Epinephrine	116-126	NBL1, DAN family BMP antagonist	Mus musculus	18-21
25939415-9	2015	CONCLUSIONS: The speed of administration of adrenaline utilising a Minijet (CSL Limited, Parkville, Victoria, Australia) is faster than using adrenaline in glass ampoules presented in their plastic packaging.	Epinephrine	44-54	chorionic somatomammotropin hormone like 1	Homo sapiens	76-79
26161982-10	2015	Replacement of epinephrine with forskolin + IBMX resulted in a marked increase in mucin production in NHBE cells in response to IL-13, and treatment with the inhibitory cAMP analogue Rp-cAMPS decreased mucin levels induced by epinephrine + IL-13.	Epinephrine	15-26	LOC100508689	Homo sapiens	82-87
26161982-10	2015	Replacement of epinephrine with forskolin + IBMX resulted in a marked increase in mucin production in NHBE cells in response to IL-13, and treatment with the inhibitory cAMP analogue Rp-cAMPS decreased mucin levels induced by epinephrine + IL-13.	Epinephrine	15-26	interleukin 13	Homo sapiens	128-133
26161982-10	2015	Replacement of epinephrine with forskolin + IBMX resulted in a marked increase in mucin production in NHBE cells in response to IL-13, and treatment with the inhibitory cAMP analogue Rp-cAMPS decreased mucin levels induced by epinephrine + IL-13.	Epinephrine	226-237	LOC100508689	Homo sapiens	202-207
25987344-2	2015	Therefore, in the current study we aimed to confirm the relation between renalase and epinephrine levels, the association between SRC and renalase levels and the association between renalase, blood pressure levels and endothelial dysfunction.	Epinephrine	86-97	renalase, FAD dependent amine oxidase	Homo sapiens	73-81
25987344-6	2015	Log renalase was correlated with log epinephrine (r = -0.302, p = 0.001) and log FMD (r = 0.642, p < 0.0001).	Epinephrine	37-48	renalase, FAD dependent amine oxidase	Homo sapiens	4-12
25224159-9	2015	RESULTS: ALE inhibited yeast (IC50 - 81.76 mug/mL) and rat intestinal alpha glucosidase (IC50 - 108.7 mug/mL), protein glycation, DPP IV enzyme (IC50 - 118.62 mug/mL) and PTP1B (IC50 - 94.66 mug/mL).	Epinephrine	9-12	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	171-176
26320637-5	2015	The dispersed solid-phase extraction (dSPE) based on the prepared adsorbent was used for extraction of three cis-diol drugs (i.e., epinephrine, isoprenaline and caffeic acid isopropyl ester) from plasma; the eluates were analyzed by HPLC-UV.	Epinephrine	131-142	Spatzle-Processing Enzyme	Drosophila melanogaster	38-42
26161982-8	2015	A clinically important long-acting beta-agonist, formoterol, was as effective as epinephrine in potentiating IL-13 induced MUC5AC transcription.	Epinephrine	81-92	interleukin 13	Homo sapiens	109-114
26161982-8	2015	A clinically important long-acting beta-agonist, formoterol, was as effective as epinephrine in potentiating IL-13 induced MUC5AC transcription.	Epinephrine	81-92	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	123-129
26161982-9	2015	IL-13 induced mucin production in the presence of epinephrine was significantly reduced by treatment with selective inhibitors of ERK1/2 (FR180204), p38 (SB203580) and JNK (SP600125).	Epinephrine	50-61	interleukin 13	Homo sapiens	0-5
26161982-9	2015	IL-13 induced mucin production in the presence of epinephrine was significantly reduced by treatment with selective inhibitors of ERK1/2 (FR180204), p38 (SB203580) and JNK (SP600125).	Epinephrine	50-61	LOC100508689	Homo sapiens	14-19
26161982-9	2015	IL-13 induced mucin production in the presence of epinephrine was significantly reduced by treatment with selective inhibitors of ERK1/2 (FR180204), p38 (SB203580) and JNK (SP600125).	Epinephrine	50-61	mitogen-activated protein kinase 3	Homo sapiens	130-136
26161982-9	2015	IL-13 induced mucin production in the presence of epinephrine was significantly reduced by treatment with selective inhibitors of ERK1/2 (FR180204), p38 (SB203580) and JNK (SP600125).	Epinephrine	50-61	mitogen-activated protein kinase 1	Homo sapiens	149-152
26161982-9	2015	IL-13 induced mucin production in the presence of epinephrine was significantly reduced by treatment with selective inhibitors of ERK1/2 (FR180204), p38 (SB203580) and JNK (SP600125).	Epinephrine	50-61	mitogen-activated protein kinase 8	Homo sapiens	168-171
25843795-5	2015	Application of adrenaline induced a significant increase of intracellular Ca(2+) and cAMP concentration ([Ca(2+)]i and [cAMP]i, respectively), and GLP-1 exocytosis in GLUTag cells.	Epinephrine	15-25	glucagon	Mus musculus	147-152
25843795-7	2015	Furthermore, overexpression of alpha2A-AR suppressed the adrenaline-induced [cAMP]i increase and exocytosis.	Epinephrine	57-67	adrenergic receptor, alpha 2a	Mus musculus	31-41
25843795-2	2015	Although adrenaline has been shown to induce glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells, the precise molecular mechanism by which adrenaline regulates GLP-1 secretion remains unknown.	Epinephrine	9-19	glucagon	Mus musculus	45-68
25843795-2	2015	Although adrenaline has been shown to induce glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells, the precise molecular mechanism by which adrenaline regulates GLP-1 secretion remains unknown.	Epinephrine	9-19	glucagon	Mus musculus	70-75
25824522-5	2015	Management of tree nut allergy consists of dietary avoidance and using epinephrine to manage serious allergic reactions.	Epinephrine	71-82	NUT midline carcinoma family member 1	Homo sapiens	19-22
25843795-2	2015	Although adrenaline has been shown to induce glucagon-like peptide-1 (GLP-1) secretion from intestinal L cells, the precise molecular mechanism by which adrenaline regulates GLP-1 secretion remains unknown.	Epinephrine	153-163	glucagon	Mus musculus	174-179
25843795-3	2015	Here we show by live cell imaging that all types of adrenergic receptors are stimulated by adrenaline in enteroendocrine L cell line GLUTag cells and are involved in GLP-1 exocytosis.	Epinephrine	91-101	glucagon	Mus musculus	166-171
27227082-7	2016	In urine, the thrombomodulin level correlated strongly with adrenaline (rho = 0.806) and noradrenaline (rho = 0.760) levels.	Epinephrine	60-70	thrombomodulin	Homo sapiens	14-28
27227082-10	2016	Median concentrations of plasma noradrenaline and urinary adrenaline were higher after exposure to +10 C than to +30 C. Thus, further evidence of the association between thrombomodulin and catecholamines was gained in a physiologically relevant setting in humans.	Epinephrine	35-45	thrombomodulin	Homo sapiens	170-184
25832730-5	2015	Histamine and epinephrine require S1P3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1).	Epinephrine	14-25	sphingosine-1-phosphate receptor 3	Mus musculus	34-38
25468485-6	2015	Significantly better PR myocardial function and neurologic deficit score were observed in epinephrine pretreated with the alpha1- or beta-blocker with decreased releases of Tn I and NT-proBNP.	Epinephrine	90-101	troponin I3, cardiac type	Rattus norvegicus	173-177
25435244-1	2015	INTRODUCTION: The systematic application of human factors engineering (HFE) principles to the development of drug-device combination products, including epinephrine auto-injectors (EAIs), has the potential to improve the effectiveness and safety of drug administration.	Epinephrine	153-164	homeostatic iron regulator	Homo sapiens	71-74
25435244-5	2015	It also describes the HFE process that was applied to the development of Auvi-Q, a novel EAI, highlighting specific steps that occurred during the product-development program.	Epinephrine	73-79	homeostatic iron regulator	Homo sapiens	22-25
25565647-15	2015	Critically ill patients receiving more than 0.48 gamma kg min of epinephrine and/or norepinephrine at ICU admission have high I-FABP concentrations.	Epinephrine	65-76	fatty acid binding protein 2	Homo sapiens	126-132
25832730-5	2015	Histamine and epinephrine require S1P3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1).	Epinephrine	14-25	sphingosine kinase 1	Mus musculus	93-113
25832730-5	2015	Histamine and epinephrine require S1P3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1).	Epinephrine	14-25	sphingosine kinase 1	Mus musculus	115-120
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Epinephrine	18-29	ferritin mitochondrial	Mus musculus	118-128
25758202-5	2015	Betaine does this most likely by supporting the methylation of norepinephrine to form epinephrine by phenylethanolamine N-methyltransferase.	Epinephrine	66-77	phenylethanolamine N-methyltransferase	Homo sapiens	101-139
25903953-6	2015	There was a positive relationship between the increased adrenal mRNA expression of TH and DBH, and the high levels of circulating adrenaline and noradrenaline (all P<0.05).	Epinephrine	130-140	TH	Sus scrofa	83-85
25786525-4	2015	The increase in systolic blood pressure (Delta-SBP) from sympathetic stimulation by L-epinephrine was 2- to 3-fold larger in HHC model in rats than that in control rats after several weeks of the treatment.	Epinephrine	84-97	spermine binding protein	Rattus norvegicus	47-50
25427855-6	2015	FSAP-/- mice were protected from lethal pulmonary thromboembolism induced by collagen/ epinephrine infusion (p< 0.01).	Epinephrine	87-98	hyaluronic acid binding protein 2	Mus musculus	0-4
25572399-6	2015	Increased transferrin receptor-1, decreased ferritin-H, and increased iron-responsive element-iron regulatory protein interaction are also observed in liver and muscle tissues of epinephrine/norepinephrine-injected mice.	Epinephrine	179-190	ferritin mitochondrial	Mus musculus	44-54
25572399-5	2015	Here we show that epinephrine/norepinephrine regulates iron homeostasis components such as transferrin receptor-1 and ferritin-H in hepatic and skeletal muscle cells by promoting the binding of iron regulatory proteins to iron-responsive elements present in the UTRs of transferrin receptor-1 and ferritin-H transcripts.	Epinephrine	18-29	ferritin mitochondrial	Mus musculus	297-307
25531177-2	2015	There remains a prevailing belief that renalase functions as a hormone, imparting an influence on vascular tone and heart rate by oxidizing circulating catecholamines, chiefly epinephrine.	Epinephrine	176-187	renalase, FAD dependent amine oxidase	Homo sapiens	39-47
25789868-11	2015	RESULTS: Adrenaline and noradrenaline correlated positively with syndecan-1 and thrombomodulin i.e., biomarkers reflecting endothelial damage (both p<0.05).	Epinephrine	9-19	syndecan 1	Homo sapiens	65-75
25789868-11	2015	RESULTS: Adrenaline and noradrenaline correlated positively with syndecan-1 and thrombomodulin i.e., biomarkers reflecting endothelial damage (both p<0.05).	Epinephrine	9-19	thrombomodulin	Homo sapiens	80-94
25541224-0	2015	Should unobstructed gasping be facilitated and confirmed before administering adrenaline, otherwise, give titrated vasopressin?	Epinephrine	78-88	arginine vasopressin	Homo sapiens	115-126
25713330-1	2015	Acute metabolic stress such as insulin-induced hypoglycemia triggers a counterregulatory response during which the release of catecholamines (epinephrine), the activation of tyrosine hydroxylase (TH) enzyme and subsequent compensatory catecholamine biosynthesis occur in the adrenal medulla.	Epinephrine	142-153	tyrosine hydroxylase	Rattus norvegicus	174-194
25520375-7	2015	DUSP3-deficient mice were more resistant to collagen- and epinephrine-induced thromboembolism compared with wild-type mice and showed severely impaired thrombus formation on ferric chloride-induced carotid artery injury.	Epinephrine	58-69	dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)	Mus musculus	0-5
25371406-1	2015	OBJECTIVE: Testing for succinate dehydrogenase subunit B (SDHB) mutations is recommended in all patients with metastatic phaeochromocytomas and paragangliomas (PPGLs), but may not be required when metastatic disease is accompanied by adrenaline production.	Epinephrine	234-244	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	23-56
25371406-1	2015	OBJECTIVE: Testing for succinate dehydrogenase subunit B (SDHB) mutations is recommended in all patients with metastatic phaeochromocytomas and paragangliomas (PPGLs), but may not be required when metastatic disease is accompanied by adrenaline production.	Epinephrine	234-244	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	58-62
25371406-2	2015	This retrospective cohort study aimed to establish the prevalence of SDHB mutations among patients with metastatic PPGLs, characterised by production of adrenaline compared with those without production of adrenaline, and to establish genotype-phenotype features of metastatic PPGLs according to underlying gene mutations.	Epinephrine	153-163	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	69-73
25371406-2	2015	This retrospective cohort study aimed to establish the prevalence of SDHB mutations among patients with metastatic PPGLs, characterised by production of adrenaline compared with those without production of adrenaline, and to establish genotype-phenotype features of metastatic PPGLs according to underlying gene mutations.	Epinephrine	206-216	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	69-73
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Epinephrine	9-19	formyl peptide receptor 1	Homo sapiens	83-103
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Epinephrine	9-19	formyl peptide receptor 1	Homo sapiens	105-109
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Epinephrine	9-19	integrin subunit alpha M	Homo sapiens	130-135
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Epinephrine	9-19	integrin subunit beta 2	Homo sapiens	136-140
25561369-5	2015	RESULTS: Adrenaline(A), noradrenaline and the beta-AR agonist isoprenaline reduced N-formyl-Met-Leu-Phe (fMLP)-induced migration, CD11b/CD18 expression, and ROS production, without affecting IL-8.	Epinephrine	9-19	C-X-C motif chemokine ligand 8	Homo sapiens	191-195
25304347-4	2015	To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes.	Epinephrine	104-115	OCTN3	Homo sapiens	146-174
25555077-7	2015	Plasma lactate and epinephrine concentrations (30 min) and sweat loss were significantly lower (P < 0.05) in RAIN compared with CON.	Epinephrine	19-30	Ras interacting protein 1	Homo sapiens	112-116
25172298-3	2015	In cytogenetic tests, six experimental concentrations of adrenaline were used in a range from 0.01-500 muM.	Epinephrine	57-67	latexin	Homo sapiens	103-106
25172298-5	2015	However, at four highest concentrations of adrenaline (5 muM, 50 muM, 150 muM and 300 muM) we observed a decreased mitotic index and cell-cycle delay.	Epinephrine	43-53	latexin	Homo sapiens	57-60
25172298-5	2015	However, at four highest concentrations of adrenaline (5 muM, 50 muM, 150 muM and 300 muM) we observed a decreased mitotic index and cell-cycle delay.	Epinephrine	43-53	latexin	Homo sapiens	65-68
25172298-5	2015	However, at four highest concentrations of adrenaline (5 muM, 50 muM, 150 muM and 300 muM) we observed a decreased mitotic index and cell-cycle delay.	Epinephrine	43-53	latexin	Homo sapiens	65-68
25172298-5	2015	However, at four highest concentrations of adrenaline (5 muM, 50 muM, 150 muM and 300 muM) we observed a decreased mitotic index and cell-cycle delay.	Epinephrine	43-53	latexin	Homo sapiens	65-68
25172298-6	2015	In addition, in the Comet assay we used adrenaline in a range from 0.0005-500 muM, at two treatment times: 15 min or 60 min.	Epinephrine	40-50	latexin	Homo sapiens	78-81
25585984-8	2015	In the rabbit model, EGF-endospray treatment significantly shortened mean bleeding time in comparison with other treatments (104.3 vs 548.0 vs 393.2 s for the EGF-endospray, the non-treated control and the epinephrine injection, respectively).	Epinephrine	206-217	pro-epidermal growth factor	Oryctolagus cuniculus	21-24
25304347-4	2015	To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes.	Epinephrine	104-115	OCTN3	Homo sapiens	176-180
25304347-4	2015	To activate nuclear adrenergic receptors in adult cardiac myocytes, uptake of endogenous catecholamines epinephrine and norepinephrine occurs via organic cation transporter 3 (OCT3), a member of the slc22a family of genes.	Epinephrine	104-115	C-C motif chemokine ligand 21	Homo sapiens	199-202
25324048-7	2015	Combining these, in the double mutant beta2-H296K-K305D, reduced salmeterol"s affinity by 275-fold, to within 4-fold of that of the beta1-adrenoceptor, without affecting the affinity or selectivity of other beta2-agonists (salbutamol, formoterol, fenoterol, clenbuterol, or adrenaline).	Epinephrine	274-284	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	38-43
25445985-10	2015	In contrast adrenaline, hydrocortisone, glucagon and H2O2 significantly increased TIGAR protein expression, whereas insulin inhibited TIGAR expression.	Epinephrine	12-22	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	82-87
25447534-0	2014	Molecular exploration of the alpha(1A)-adrenoceptor orthosteric site: binding site definition for epinephrine, HEAT and prazosin.	Epinephrine	98-109	adrenoceptor alpha 1A	Homo sapiens	29-51
25478705-2	2015	In vitro, norepinephrine and epinephrine inhibit placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which protects the fetus from F overexposure by inactivating it to cortisone (E).	Epinephrine	13-24	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	59-114
26767546-8	2015	Although no significant difference was observed between two groups, but survival rates after hospital discharge in group that receiving vasopressin-epinephrine was significantly higher than those patients that only got only epinephrine.	Epinephrine	148-159	arginine vasopressin	Homo sapiens	136-147
25566095-7	2014	beta3-adrenoceptor antagonist (SR59230A) reduced tyramine-stimulated norepinephrine release in both strains and the secretion of epinephrine in hypertensive rats.	Epinephrine	72-83	adrenoceptor beta 3	Rattus norvegicus	0-18
25109347-6	2014	Plasma adrenaline correlated negatively with the relative amount of myocardial thrombomodulin transcripts and positively with plasma thrombomodulin in SH.	Epinephrine	7-17	thrombomodulin	Rattus norvegicus	79-93
25446929-7	2014	treatment during CPR with epinephrine plus NDP-alpha-MSH (340 mug/kg) almost completely restored the basal conditions of MAP and HR, reversed metabolic acidosis, induced left ventricle up-regulation of pJAK2, pTyr-STAT3 and IL-10, attenuated oxidative stress, down-regulated TNF-alpha and IL-6 levels, and improved survival rate by 81%.	Epinephrine	26-37	signal transducer and activator of transcription 3	Rattus norvegicus	214-219
25446929-7	2014	treatment during CPR with epinephrine plus NDP-alpha-MSH (340 mug/kg) almost completely restored the basal conditions of MAP and HR, reversed metabolic acidosis, induced left ventricle up-regulation of pJAK2, pTyr-STAT3 and IL-10, attenuated oxidative stress, down-regulated TNF-alpha and IL-6 levels, and improved survival rate by 81%.	Epinephrine	26-37	interleukin 10	Rattus norvegicus	224-229
25446929-7	2014	treatment during CPR with epinephrine plus NDP-alpha-MSH (340 mug/kg) almost completely restored the basal conditions of MAP and HR, reversed metabolic acidosis, induced left ventricle up-regulation of pJAK2, pTyr-STAT3 and IL-10, attenuated oxidative stress, down-regulated TNF-alpha and IL-6 levels, and improved survival rate by 81%.	Epinephrine	26-37	tumor necrosis factor	Rattus norvegicus	275-284
25446929-7	2014	treatment during CPR with epinephrine plus NDP-alpha-MSH (340 mug/kg) almost completely restored the basal conditions of MAP and HR, reversed metabolic acidosis, induced left ventricle up-regulation of pJAK2, pTyr-STAT3 and IL-10, attenuated oxidative stress, down-regulated TNF-alpha and IL-6 levels, and improved survival rate by 81%.	Epinephrine	26-37	interleukin 6	Rattus norvegicus	289-293
25109347-6	2014	Plasma adrenaline correlated negatively with the relative amount of myocardial thrombomodulin transcripts and positively with plasma thrombomodulin in SH.	Epinephrine	7-17	thrombomodulin	Rattus norvegicus	133-147
25205821-7	2014	Interestingly, IL-6 augments glucagon secretion from both sites only in the presence of an accompanying stressor (such as epinephrine).	Epinephrine	122-133	interleukin 6	Mus musculus	15-19
25431019-7	2014	administered AngII acts on brain AT1 receptors, thereby inducing the secretion of adrenaline and pressor responses.	Epinephrine	82-92	angiotensinogen	Rattus norvegicus	13-18
25431019-7	2014	administered AngII acts on brain AT1 receptors, thereby inducing the secretion of adrenaline and pressor responses.	Epinephrine	82-92	angiotensin II receptor, type 1a	Rattus norvegicus	33-36
25161169-1	2014	It has been suggested that there is a link between epinephrine synthesis and the development of beta2-adrenoceptor-mediated effects, but it remains to be determined whether this development is triggered by epinephrine.	Epinephrine	51-62	adrenergic receptor, beta 2	Mus musculus	96-114
25010822-7	2014	RESULTS: BF1 inhibited the hypersensitivity and paw edema induced by intraplantar injection of carrageenan, BK, and PGE2 (P < 0.001), and it was effective in reducing the hypersensitivity evoked by complete Freund adjuvant or epinephrine (P < 0.001) but not by lipopolysaccharide (P = 0.2570).	Epinephrine	229-240	forkhead box G1	Mus musculus	9-12
25161169-7	2014	Epinephrine is absent in Pnmt-KO mice.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Mus musculus	25-29
25161169-12	2014	In conclusion, epinephrine is crucial for beta2-adrenoceptor-mediated vasodilation and facilitation of norepinephrine release.	Epinephrine	15-26	adrenergic receptor, beta 2	Mus musculus	42-60
25117409-4	2014	Normally, hypoglycemia triggers both the release and biosynthesis of epinephrine through activation of nicotinic acetylcholine receptors (nAChR) on the adrenal glands.	Epinephrine	69-80	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	103-136
25117409-4	2014	Normally, hypoglycemia triggers both the release and biosynthesis of epinephrine through activation of nicotinic acetylcholine receptors (nAChR) on the adrenal glands.	Epinephrine	69-80	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	138-143
25200305-8	2014	8-pCPT-2"-O-Me-cAMP, an Epac-selective cAMP analogue, and glibenclamide, a sulfonylurea, synergistically activate Epac2A and Rap1, whereas adrenaline, which suppresses cAMP production in pancreatic beta-cells, blocks activation of Epac2A and Rap1 by glibenclamide.	Epinephrine	139-149	RAP1A, member of RAS oncogene family	Homo sapiens	125-129
25049076-1	2014	The beta2-adrenergic receptor (beta2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline.	Epinephrine	161-171	adrenoceptor beta 2	Homo sapiens	4-29
25049076-1	2014	The beta2-adrenergic receptor (beta2AR) is the prototypic member of G protein-coupled receptors (GPCRs) involved in the production of physiological responses to adrenaline and noradrenaline.	Epinephrine	161-171	adrenoceptor beta 2	Homo sapiens	31-38
24886966-12	2014	Prednisolone and epinephrine-induced leukocyte cell death was prevented by GCR and beta2-AR blockade, respectively.	Epinephrine	17-28	nuclear receptor subfamily 3, group C, member 1	Mus musculus	75-78
24886966-12	2014	Prednisolone and epinephrine-induced leukocyte cell death was prevented by GCR and beta2-AR blockade, respectively.	Epinephrine	17-28	adrenergic receptor, beta 2	Mus musculus	83-91
24940712-6	2014	In fact, under conditions of increased AGE/ALE levels, galectin-3 ablation was associated with tissue-specific outcomes, reflecting the AGE/ALE-receptor function of this lectin.	Epinephrine	43-46	galectin 3	Homo sapiens	55-65
24863408-5	2014	While the beta2-adrenoceptor-selective antagonist ICI 118,551 completely blocked adrenaline-induced TG2 mRNA expression, the beta2-adrenoceptor specific agonist salmeterol increased TG2 expression.	Epinephrine	81-91	adrenergic receptor, beta 2	Mus musculus	10-28
24947582-8	2014	RESULTS: Adrenaline and isoprenaline increased somatostatin content and transcription through the activation of beta1-/beta2-adrenergic receptors (beta1-/beta2ARs).	Epinephrine	9-19	somatostatin	Mus musculus	47-59
24863408-3	2014	In the present study, we examined the effects of the stress-related catecholamines adrenaline and noradrenaline on macrophage expression of TG2 in RAW264.7 murine macrophages and murine bone marrow-derived macrophages.	Epinephrine	83-93	transglutaminase 2, C polypeptide	Mus musculus	140-143
24863408-5	2014	While the beta2-adrenoceptor-selective antagonist ICI 118,551 completely blocked adrenaline-induced TG2 mRNA expression, the beta2-adrenoceptor specific agonist salmeterol increased TG2 expression.	Epinephrine	81-91	transglutaminase 2, C polypeptide	Mus musculus	100-103
24863408-6	2014	Noradrenaline also increased TG2 mRNA expression at higher doses than the effective doses of adrenaline.	Epinephrine	3-13	transglutaminase 2, C polypeptide	Mus musculus	29-32
24863408-7	2014	The effect of adrenaline on TG2 mRNA expression was mimicked by treatment with the membrane-permeable cAMP analog 8-Br-cAMP.	Epinephrine	14-24	transglutaminase 2, C polypeptide	Mus musculus	28-31
24863408-8	2014	Thus, increased intracellular cAMP following stimulation of beta2-adrenoceptors appeared to be responsible for adrenaline-induced TG2 expression.	Epinephrine	111-121	transglutaminase 2, C polypeptide	Mus musculus	130-133
24907310-9	2014	Consistent with its cAMP dependence, however, SUMO1 enhanced alpha-cell exocytosis and glucagon secretion stimulated by adrenaline.	Epinephrine	120-130	small ubiquitin like modifier 1	Homo sapiens	46-51
25243022-7	2014	Platelets were treated with ADP and epinephrine in decreasing concentrations of 2.34, 1.17, and 0.58 muM, as well as, 11.0, 1.1, and 0.55 muM, respectively.	Epinephrine	36-47	latexin	Homo sapiens	101-104
25243022-10	2014	There was a significant difference in the detection of increased platelet aggregation using 11.0 muM and 0.55 muM epinephrine and 0.58 muM ADP.	Epinephrine	114-125	latexin	Homo sapiens	110-113
25243022-10	2014	There was a significant difference in the detection of increased platelet aggregation using 11.0 muM and 0.55 muM epinephrine and 0.58 muM ADP.	Epinephrine	114-125	latexin	Homo sapiens	110-113
25243022-11	2014	With both agonists, ROC analysis showed an area under the curve of >0.8 for 11.0 muM epinephrine and 2.34 muM ADP.	Epinephrine	88-99	latexin	Homo sapiens	84-87
25243022-12	2014	However, for MS patients, 11.0 muM epinephrine had a slightly better diagnostic efficiency than 2.34 muM ADP.	Epinephrine	35-46	latexin	Homo sapiens	31-34
25243022-13	2014	CONCLUSIONS: It was found that 11.0 muM epinephrine and 2.34 muM ADP detected better platelet aggregation in patients with MS than in healthy subject.	Epinephrine	40-51	latexin	Homo sapiens	36-39
24871568-3	2014	OBJECTIVE: Determine if vasopressin therapy in combination with epinephrine was associated with improved outcomes in patients with cardiac arrest compared to epinephrine alone.	Epinephrine	158-169	arginine vasopressin	Homo sapiens	24-35
25111139-6	2014	In adrenals ADRA2C was twofold greater expressed than the related receptor gene ADRA2A, indicating that ADRA2C is the predominant modulator of epinephrine release but no strain differences were measured.	Epinephrine	143-154	adrenoceptor alpha 2C	Gallus gallus	104-110
24871568-10	2014	Subgroup analysis of ROSC in patients with an arterial pH of <7.2 (n = 35) showed an increased rate of ROSC (63% vs 37%, P = 0.01) in the vasopressin plus epinephrine group versus the epinephrine alone group, respectively.	Epinephrine	187-198	arginine vasopressin	Homo sapiens	141-152
24779394-11	2014	On a functional level, NPY acutely increased intracellular calcium levels and enhanced vasoconstriction of lung vessels preconstricted with adrenaline.	Epinephrine	140-150	neuropeptide Y	Homo sapiens	23-26
24871568-12	2014	CONCLUSIONS: Vasopressin in combination with epinephrine demonstrated improved ROSC in cardiac arrest patients with initial arterial pH <7.2 compared with epinephrine alone, without improving survival to hospital discharge.	Epinephrine	158-169	arginine vasopressin	Homo sapiens	13-24
24891006-12	2014	The post-race fall in plasma TNF-alpha in the CSCI group could be related to the inhibitory effect of rising IL-6 in the presence of normal monocyte count and stable adrenaline level.	Epinephrine	166-176	tumor necrosis factor	Homo sapiens	29-38
24768611-8	2014	RESULTS: Adult CASQ2(Delta/Delta) mice suffer from complex ventricular arrhythmia at rest and ventricular tachycardia during treadmill exercise and after epinephrine injection.	Epinephrine	154-165	calsequestrin 2	Mus musculus	15-20
24840080-9	2014	Removing Cl(-) or application of CFTR(inh) -172, an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR), abolished adrenaline-induced ISC responses.	Epinephrine	135-145	CF transmembrane conductance regulator	Rattus norvegicus	33-37
24840080-9	2014	Removing Cl(-) or application of CFTR(inh) -172, an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR), abolished adrenaline-induced ISC responses.	Epinephrine	135-145	CF transmembrane conductance regulator	Rattus norvegicus	65-116
24840080-9	2014	Removing Cl(-) or application of CFTR(inh) -172, an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR), abolished adrenaline-induced ISC responses.	Epinephrine	135-145	CF transmembrane conductance regulator	Rattus norvegicus	118-122
24861471-2	2014	LAT gel (lidocaine, adrenaline, and tetracaine) is a safe and effective topical anaesthetic that can aid with the closure of uncomplicated lacerations, particularly in the paediatric trauma setting.	Epinephrine	20-30	linker for activation of T cells	Homo sapiens	0-3
24614156-2	2014	Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration.	Epinephrine	29-40	adrenoceptor beta 2	Homo sapiens	55-80
24614156-2	2014	Previous studies showed that epinephrine activates the beta2-adrenergic receptor (B2AR), impairing keratinocyte migration.	Epinephrine	29-40	adrenoceptor beta 2	Homo sapiens	82-86
24464623-4	2014	More specific, epinephrine stimulates G-protein coupled beta2 adenoreceptors (beta2AR) which are located on ventricular myocytes.	Epinephrine	15-26	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	56-61
24464623-4	2014	More specific, epinephrine stimulates G-protein coupled beta2 adenoreceptors (beta2AR) which are located on ventricular myocytes.	Epinephrine	15-26	adrenoceptor beta 2	Homo sapiens	78-85
24891006-12	2014	The post-race fall in plasma TNF-alpha in the CSCI group could be related to the inhibitory effect of rising IL-6 in the presence of normal monocyte count and stable adrenaline level.	Epinephrine	166-176	interleukin 6	Homo sapiens	109-113
24657150-1	2014	We recently reported that intracerebroventricularly administered 2-arachidonoylglycerol elevated plasma noradrenaline and adrenaline by brain monoacylglycerol lipase- (MGL) and cyclooxygenase-mediated mechanisms in the rat.	Epinephrine	107-117	monoglyceride lipase	Rattus norvegicus	142-165
24858852-11	2014	EPC exposure to epinephrine or norepinephrine showed negative dose-response relationships on cell adhesion to fibronectin and collagen; both catecholamines stimulated early EPC growth, but epinephrine inhibited late EPC growth.	Epinephrine	16-27	fibronectin 1	Homo sapiens	110-121
24858852-11	2014	EPC exposure to epinephrine or norepinephrine showed negative dose-response relationships on cell adhesion to fibronectin and collagen; both catecholamines stimulated early EPC growth, but epinephrine inhibited late EPC growth.	Epinephrine	34-45	fibronectin 1	Homo sapiens	110-121
25313767-6	2014	SOD was assayed by inhibition and autoxidation of adrenaline method.	Epinephrine	50-60	superoxide dismutase 1	Homo sapiens	0-3
25017529-11	2014	IgE-mediated reactions were associated with greater severity, manifested by the rates of cardiovascular dysfunction, hospitalization, and use of epinephrine.	Epinephrine	145-156	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
24657150-1	2014	We recently reported that intracerebroventricularly administered 2-arachidonoylglycerol elevated plasma noradrenaline and adrenaline by brain monoacylglycerol lipase- (MGL) and cyclooxygenase-mediated mechanisms in the rat.	Epinephrine	107-117	monoglyceride lipase	Rattus norvegicus	168-171
24657150-2	2014	These results suggest that 2-arachidonoylglycerol is hydrolyzed by MGL to free arachidonic acid, which is further metabolized to prostaglandins (PGs) by cyclooxygenase in the brain, thereby elevating plasma noradrenaline and adrenaline.	Epinephrine	210-220	monoglyceride lipase	Rattus norvegicus	67-70
24780611-4	2014	APN intracerebroventricular infusions decreased uncoupling protein 1 (UCP1) expression in brown adipose tissue, epinephrine and norepinephrine serum levels, and osteoclast numbers, whereas osteoblast osteogenic marker expression and trabecular bone mass increased in APN-KO and WT mice.	Epinephrine	112-123	adiponectin, C1Q and collagen domain containing	Mus musculus	0-3
24945349-7	2014	Starvation of wild-type mice or stimulation of adipose tissue explants with the catabolic hormone, adrenaline, translocated both PRIP and PP2A from the cytosol to lipid droplets, but the translocation of PP2A was significantly reduced in PRIP-KO adipocytes.	Epinephrine	99-109	phospholipase C-like 1	Mus musculus	129-133
24945349-7	2014	Starvation of wild-type mice or stimulation of adipose tissue explants with the catabolic hormone, adrenaline, translocated both PRIP and PP2A from the cytosol to lipid droplets, but the translocation of PP2A was significantly reduced in PRIP-KO adipocytes.	Epinephrine	99-109	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	138-142
24945349-7	2014	Starvation of wild-type mice or stimulation of adipose tissue explants with the catabolic hormone, adrenaline, translocated both PRIP and PP2A from the cytosol to lipid droplets, but the translocation of PP2A was significantly reduced in PRIP-KO adipocytes.	Epinephrine	99-109	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	204-208
24945349-7	2014	Starvation of wild-type mice or stimulation of adipose tissue explants with the catabolic hormone, adrenaline, translocated both PRIP and PP2A from the cytosol to lipid droplets, but the translocation of PP2A was significantly reduced in PRIP-KO adipocytes.	Epinephrine	99-109	phospholipase C-like 1	Mus musculus	238-242
24945349-8	2014	Consistently, the phosphatase activity associated with lipid droplet fraction in PRIP-KO adipocytes was significantly reduced and was independent of adrenaline stimulation.	Epinephrine	149-159	phospholipase C-like 1	Mus musculus	81-85
24418943-11	2014	Platelet aggregation with epinephrine was higher in CYP4F2 GA genotype carriers than in GG (P = 0.04) or AA (P = 0.01) carriers.	Epinephrine	26-37	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	52-58
24901844-6	2014	Intracellular Ca2+ elevation in lacrimal acinar cells after acetylcholine and epinephrine stimulation was abolished in Itpr2-/-;Itpr3-/- mice.	Epinephrine	78-89	inositol 1,4,5-triphosphate receptor 2	Mus musculus	119-124
24901844-6	2014	Intracellular Ca2+ elevation in lacrimal acinar cells after acetylcholine and epinephrine stimulation was abolished in Itpr2-/-;Itpr3-/- mice.	Epinephrine	78-89	inositol 1,4,5-triphosphate receptor 3	Mus musculus	128-133
24723553-5	2014	APPROACH AND RESULTS: Aggregation to 5 increasing doses of epinephrine (from 0.156 to 10 mumol/L) was assessed in aggregation units by Multiplate Analyzer and platelet reactivity in P2Y12 reactivity units and % inhibition by VerifyNow P2Y12 assay before percutaneous revascularization.	Epinephrine	59-70	purinergic receptor P2Y12	Homo sapiens	235-240
24723553-11	2014	CONCLUSIONS: The 6.3-kb alpha2A-AR variant is associated with increased platelet reactivity to epinephrine and has an additive effect along with CYP2C19*2 loss-of-function allele on P2Y12-mediated platelet responses in patients with stable angina on dual antiplatelet therapy.	Epinephrine	95-106	adrenoceptor alpha 2A	Homo sapiens	24-34
24723553-2	2014	The 6.3-kb variant of alpha2A-AR gene is associated with increased epinephrine-induced platelet aggregation in healthy volunteers.	Epinephrine	67-78	adrenoceptor alpha 2A	Homo sapiens	22-32
24418943-13	2014	The novelty is that the platelet aggregation after induction with epinephrine is influenced by CYP4F2 G1347A genotype.	Epinephrine	66-77	cytochrome P450 family 4 subfamily F member 2	Homo sapiens	95-101
24844639-0	2014	Effect of beta2-adrenergic receptor polymorphisms on epinephrine and exercise-stimulated lipolysis in humans.	Epinephrine	53-64	adrenoceptor beta 2	Homo sapiens	10-35
24629015-6	2014	Ninety days after MI both WT and beta2 KO mice presented to cardiac dysfunction and remodelling accompanied by significantly increased norepinephrine and epinephrine plasma levels, exercise intolerance, changes towards more glycolytic fibres and vascular rarefaction in plantaris muscle.	Epinephrine	138-149	hemoglobin, beta adult minor chain	Mus musculus	33-38
24684300-8	2014	Incubation of cultured smooth muscle cells with adrenaline resulted in a significant increase in their proliferation and G0/G1 to S phase progression, which was associated with activation of extracellular signal-regulated kinase, enhanced expression of cell cycle regulatory molecules such as cyclin D1, and cyclin E, and phosphorylation of retinoblastoma protein.	Epinephrine	48-58	cyclin D1	Rattus norvegicus	293-302
24684300-8	2014	Incubation of cultured smooth muscle cells with adrenaline resulted in a significant increase in their proliferation and G0/G1 to S phase progression, which was associated with activation of extracellular signal-regulated kinase, enhanced expression of cell cycle regulatory molecules such as cyclin D1, and cyclin E, and phosphorylation of retinoblastoma protein.	Epinephrine	48-58	cyclin E1	Rattus norvegicus	308-316
24607627-7	2014	We then demonstrated that MAOA suppressed norepinephrine/epinephrine (NE/E)-induced HCC invasion and anoikis inhibition, and uncovered that the effects of NE/E on HCC behaviors were primarily mediated through alpha 1A (ADRA1A) and beta 2 adrenergic receptors (ADRB2).	Epinephrine	45-56	monoamine oxidase A	Homo sapiens	26-30
24844639-3	2014	We hypothesized that variations in the amino acid at position 16 of the beta2-adrenergic receptor would result in different lipolytic responses to intravenous epinephrine and exercise.	Epinephrine	159-170	adrenoceptor beta 2	Homo sapiens	72-97
24705724-5	2014	Interestingly, epinephrine stimulated two anion secretory channels, the cystic fibrosis transmembrane conductance regulator and a Ca(2+)-activated Cl(-) channel, with the characteristics of transmembrane protein 16A, thereby potentially altering mucociliary clearance via multiple channels.	Epinephrine	15-26	CF transmembrane conductance regulator	Homo sapiens	72-123
24799686-11	2014	In the intervention group, plasma levels of the anti-inflammatory cytokine IL-10 increased more rapidly after endotoxin administration, correlated strongly with preceding epinephrine levels, and were higher.	Epinephrine	171-182	interleukin 10	Homo sapiens	75-80
24705724-5	2014	Interestingly, epinephrine stimulated two anion secretory channels, the cystic fibrosis transmembrane conductance regulator and a Ca(2+)-activated Cl(-) channel, with the characteristics of transmembrane protein 16A, thereby potentially altering mucociliary clearance via multiple channels.	Epinephrine	15-26	anoctamin 1	Homo sapiens	130-160
24497580-5	2014	Analysis of germline VGF-knockout mouse adrenal medulla revealed decreased LDCV size in noradrenergic chromaffin cells, increased adrenal norepinephrine and epinephrine content and circulating plasma epinephrine, and decreased adrenal CgB.	Epinephrine	141-152	VGF nerve growth factor inducible	Mus musculus	21-24
24680993-8	2014	Moreover, DeHE (0.1 and 0.3 muM) suppressed delayed afterdepolarizations and aftercontractions, induced by epinephrine and high [Ca(2+)]o in atria.	Epinephrine	107-118	latexin	Homo sapiens	28-31
24155262-3	2014	Epinephrine is synthesized from norepinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) and works as an endogenous adrenoceptor ligand secreted peripherally by the adrenal medulla.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Mus musculus	61-99
24155262-3	2014	Epinephrine is synthesized from norepinephrine by the enzyme phenylethanolamine N-methyltransferase (PNMT) and works as an endogenous adrenoceptor ligand secreted peripherally by the adrenal medulla.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Mus musculus	101-105
24497580-5	2014	Analysis of germline VGF-knockout mouse adrenal medulla revealed decreased LDCV size in noradrenergic chromaffin cells, increased adrenal norepinephrine and epinephrine content and circulating plasma epinephrine, and decreased adrenal CgB.	Epinephrine	157-168	VGF nerve growth factor inducible	Mus musculus	21-24
26118169-3	2014	The study evaluates and compares the protective effect of Angiotensin Converting Enzyme (ACE) inhibitor and AT1 receptor blocker in adrenaline induced oxidative stress in rats.	Epinephrine	132-142	angiotensin I converting enzyme	Rattus norvegicus	58-87
24593912-6	2014	Low concentrations (100 muM) of MK-801 and memantine reduced adrenaline-induced CD62P expression by 47 +- 5 and 42 +- 3%, respectively, and inhibited adrenaline-induced platelet aggregation by 17 +- 6 and 25 +- 5%, respectively (P<0.05).	Epinephrine	61-71	selectin P	Homo sapiens	80-85
25031678-10	2014	We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.	Epinephrine	28-39	adrenoceptor beta 2	Homo sapiens	110-115
25031678-10	2014	We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.	Epinephrine	28-39	C-C motif chemokine ligand 3	Homo sapiens	117-121
25031678-10	2014	We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.	Epinephrine	28-39	G protein-coupled receptor associated sorting protein 1	Homo sapiens	123-130
25031678-10	2014	We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.	Epinephrine	28-39	heat shock protein family B (small) member 1	Homo sapiens	132-137
25031678-10	2014	We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.	Epinephrine	28-39	RAB2A, member RAS oncogene family	Homo sapiens	139-144
25031678-10	2014	We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.	Epinephrine	28-39	regulator of G protein signaling 2	Homo sapiens	146-150
25031678-10	2014	We can conclude that plasma epinephrine concentration and genes related to the adrenergic system such as ADM, ADRB2, CCL3, GPRASP1, HSPB1, RAB2A, RGS2 and ROCK1 seem to have an influence on the response to high-intensity exercise in trained cyclists.	Epinephrine	28-39	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	155-160
26118169-3	2014	The study evaluates and compares the protective effect of Angiotensin Converting Enzyme (ACE) inhibitor and AT1 receptor blocker in adrenaline induced oxidative stress in rats.	Epinephrine	132-142	angiotensin I converting enzyme	Rattus norvegicus	89-92
24599883-7	2014	By contrast, plasma epinephrine levels positively correlated with plasma renalase activity (r = 0.67, P < 0.0001) and negatively correlated with plasma renalase levels (r = -0.62, P < 0.003).	Epinephrine	20-31	renalase, FAD dependent amine oxidase	Homo sapiens	73-81
24599883-7	2014	By contrast, plasma epinephrine levels positively correlated with plasma renalase activity (r = 0.67, P < 0.0001) and negatively correlated with plasma renalase levels (r = -0.62, P < 0.003).	Epinephrine	20-31	renalase, FAD dependent amine oxidase	Homo sapiens	155-163
24599883-10	2014	It is suggested that epinephrine-mediated activation of circulating renalase may occur in renal transplant recipients with good recovery of renal function.	Epinephrine	21-32	renalase, FAD dependent amine oxidase	Homo sapiens	68-76
24632837-3	2014	In vitro lipolytic stimulation by epinephrine (100 muM) or by a lipolytic cocktail (30 muM palmitate, 4 muM forskolin, and 0.5 muM ionomycin, PFI) resulted in increases in PLIN3 protein content.	Epinephrine	34-45	perilipin 3	Homo sapiens	172-177
24559277-1	2014	OBJECT: The biogenic amines (dopamine, epinephrine, norepinephrine, and serotonin) are involved in the regulation of multiple neuronal functions, and changes in monoamine concentrations in the CSF have been detected in several disorders.	Epinephrine	39-50	colony stimulating factor 2	Homo sapiens	193-196
24663151-1	2014	The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline.	Epinephrine	117-127	adrenoceptor beta 1	Homo sapiens	4-22
24663151-1	2014	The beta1-adrenoceptor (beta1AR) is a G protein-coupled receptor (GPCR) that is activated by the endogenous agonists adrenaline and noradrenaline.	Epinephrine	117-127	adrenoceptor beta 1	Homo sapiens	24-31
25206865-4	2014	The results demonstrated that, compared with epinephrine alone, the pathological damage to nerve cells was lessened, and the levels of c-Jun N-terminal kinase and p38 expression were significantly decreased in the hippocampus after treatment with vasopressin alone or the vasopressin and epinephrine combination.	Epinephrine	45-56	arginine vasopressin	Rattus norvegicus	247-258
24636497-8	2014	Importantly, stress-induced release of epinephrine or opioids had no impact on plasma IL-12 levels, while pharmacological administration of epinephrine reduced plasma IL-12 levels by elevating corticosterone levels.	Epinephrine	140-151	interleukin 12B	Rattus norvegicus	167-172
24564195-9	2014	In addition, the pharmaceutical product epinephrine was partially oxidized to adrenochrome by the O2( )  released from the Co(II)-poly(EGDE-DA)/H2O2 heterogeneous system.	Epinephrine	40-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	123-130
25206865-4	2014	The results demonstrated that, compared with epinephrine alone, the pathological damage to nerve cells was lessened, and the levels of c-Jun N-terminal kinase and p38 expression were significantly decreased in the hippocampus after treatment with vasopressin alone or the vasopressin and epinephrine combination.	Epinephrine	288-299	arginine vasopressin	Rattus norvegicus	247-258
25206865-4	2014	The results demonstrated that, compared with epinephrine alone, the pathological damage to nerve cells was lessened, and the levels of c-Jun N-terminal kinase and p38 expression were significantly decreased in the hippocampus after treatment with vasopressin alone or the vasopressin and epinephrine combination.	Epinephrine	288-299	arginine vasopressin	Rattus norvegicus	272-283
24632890-4	2014	Recently, we have reported that Rac1 regulates epinephrine-induced WPB exocytosis following its activation by phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 (PREX1).	Epinephrine	47-58	Rac family small GTPase 1	Homo sapiens	32-36
24632890-4	2014	Recently, we have reported that Rac1 regulates epinephrine-induced WPB exocytosis following its activation by phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 (PREX1).	Epinephrine	47-58	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	Homo sapiens	183-188
25272708-5	2014	This suggests that the effect of adrenaline caused an increase in erythrocyte entry of Ca2+, activation of calmodulin, cyclooxygenase, phospholipase A2 and the release of K+ from red blood cell through the Ca(2+)-dependent K+ channels, which is regarded as a manifestation of eryptosis.	Epinephrine	33-43	phospholipase A2 group IB	Homo sapiens	135-151
24485888-5	2014	Activation of Galphaq proteins was also detectable by the addition of carbachol via muscarinic acetylcholine M1 receptors, (-)-epinephrine, and dopamine, but not by L-glutamate or (+-)-baclofen.	Epinephrine	123-138	G protein subunit alpha q	Rattus norvegicus	14-21
24374096-5	2014	The effect of adrenaline on REDD1 mRNA expression was mimicked by treatment with membrane-permeable cAMP analog 8-Br-cAMP.	Epinephrine	14-24	DNA-damage-inducible transcript 4	Mus musculus	28-33
24412598-6	2014	Epinephrine (Ep) treatment accelerated the FG-induced TNF-alpha production and TLR5 expression on the Caco2, but not RAW264 cells.	Epinephrine	0-11	tumor necrosis factor	Homo sapiens	54-63
24374096-1	2014	In the present study, we examined the effect of stress-related catecholamines adrenaline and noradrenaline on macrophage expression of a new host defense factor REDD1 using murine macrophage cell line RAW264.7 and murine peritoneal macrophages.	Epinephrine	78-88	DNA-damage-inducible transcript 4	Mus musculus	161-166
24374096-2	2014	Short-term adrenaline exposure (15-60 min) upregulated REDD1 mRNA expression and its protein synthesis in macrophages.	Epinephrine	11-21	DNA-damage-inducible transcript 4	Mus musculus	55-60
24374096-6	2014	Thus, increased intracellular cAMP level resulting from beta2-adrenoceptor stimulation appeared to be responsible for adrenaline-induced REDD1 mRNA expression.	Epinephrine	118-128	adrenergic receptor, beta 2	Mus musculus	56-74
24374096-3	2014	This adrenaline-induced REDD1 expression was completely blocked by beta2-adrenoceptor selective antagonist ICI 118,551, whereas beta2-adrenoceptor specific agonist salmeterol markedly enhanced REDD1 expression.	Epinephrine	5-15	DNA-damage-inducible transcript 4	Mus musculus	24-29
24374096-3	2014	This adrenaline-induced REDD1 expression was completely blocked by beta2-adrenoceptor selective antagonist ICI 118,551, whereas beta2-adrenoceptor specific agonist salmeterol markedly enhanced REDD1 expression.	Epinephrine	5-15	adrenergic receptor, beta 2	Mus musculus	67-85
24412598-6	2014	Epinephrine (Ep) treatment accelerated the FG-induced TNF-alpha production and TLR5 expression on the Caco2, but not RAW264 cells.	Epinephrine	0-11	toll like receptor 5	Homo sapiens	79-83
24374096-6	2014	Thus, increased intracellular cAMP level resulting from beta2-adrenoceptor stimulation appeared to be responsible for adrenaline-induced REDD1 mRNA expression.	Epinephrine	118-128	DNA-damage-inducible transcript 4	Mus musculus	137-142
24374096-3	2014	This adrenaline-induced REDD1 expression was completely blocked by beta2-adrenoceptor selective antagonist ICI 118,551, whereas beta2-adrenoceptor specific agonist salmeterol markedly enhanced REDD1 expression.	Epinephrine	5-15	DNA-damage-inducible transcript 4	Mus musculus	193-198
23085509-5	2014	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Epinephrine	291-302	interferon gamma	Homo sapiens	30-46
24057680-1	2014	PURPOSE: In mouse models of prostate cancer, increased epinephrine levels accelerated tumor growth via the beta2-adrenoreceptor/PKA signaling pathway.	Epinephrine	55-66	adrenergic receptor, beta 2	Mus musculus	107-127
24057680-2	2014	It is unknown, however, whether men experience increased epinephrine levels sufficient to activate the beta2-adrenoreceptor/PKA pathway in the prostate gland.	Epinephrine	57-68	adrenoceptor beta 2	Homo sapiens	103-123
24057680-7	2014	Pearson and Spearman"s rank correlations were analyzed to assess relationships between blood epinephrine levels and phosphorylation of CREB, BAD, AKT, and ERK.	Epinephrine	93-104	cAMP responsive element binding protein 1	Homo sapiens	135-139
24057680-7	2014	Pearson and Spearman"s rank correlations were analyzed to assess relationships between blood epinephrine levels and phosphorylation of CREB, BAD, AKT, and ERK.	Epinephrine	93-104	mitogen-activated protein kinase 1	Homo sapiens	155-158
24057680-9	2014	A strong positive correlation was observed between increased epinephrine levels and CREB phosphorylation.	Epinephrine	61-72	cAMP responsive element binding protein 1	Homo sapiens	84-88
24057680-11	2014	CONCLUSION: Our results suggest that increased blood epinephrine levels activate the beta2-adrenoreceptor/PKA signaling pathway in human prostate glands.	Epinephrine	53-64	adrenoceptor beta 2	Homo sapiens	85-105
24057680-12	2014	These results will inform future studies to examine whether beta2-selective blockers can inhibit activation of the epinephrine/ADRB2/PKA pathway in prostate tumors of men with increased epinephrine levels and explore the use of beta2-selective blockers as adjuvant therapy for prostate cancer.	Epinephrine	115-126	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	60-65
24057680-12	2014	These results will inform future studies to examine whether beta2-selective blockers can inhibit activation of the epinephrine/ADRB2/PKA pathway in prostate tumors of men with increased epinephrine levels and explore the use of beta2-selective blockers as adjuvant therapy for prostate cancer.	Epinephrine	115-126	adrenoceptor beta 2	Homo sapiens	127-132
24465756-2	2014	In addition to the importance of hha in positive regulation of motility, a two-component quorum sensing pathway encoded by the qseBC genes has been shown to activate bacterial motility in response to mammalian stress hormones epinephrine and norepinephrine as well as bacterially produced autoinducer-3.	Epinephrine	226-237	anosmin 1	Homo sapiens	33-36
24121404-4	2014	Prolonged systemic exposure of epinephrine resulted in persistent PMN trafficking to the wound site via an IL-6-mediated mechanism, and this in turn impaired wound repair.	Epinephrine	31-42	interleukin 6	Mus musculus	107-111
24121404-5	2014	Further, we demonstrate that beta2-adrenergic receptor-dependent activation of proinflammatory macrophages is critical for epinephrine-mediated IL-6 production.	Epinephrine	123-134	adrenergic receptor, beta 2	Mus musculus	29-54
24121404-5	2014	Further, we demonstrate that beta2-adrenergic receptor-dependent activation of proinflammatory macrophages is critical for epinephrine-mediated IL-6 production.	Epinephrine	123-134	interleukin 6	Mus musculus	144-148
24374286-5	2014	Intravenous administration of adrenaline increased SNAP-25 phosphorylation, although stress-induced phosphorylation was still observed in adrenalectomized mice.	Epinephrine	30-40	synaptosomal-associated protein 25	Mus musculus	51-58
24283667-0	2014	Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies.	Epinephrine	82-93	AKT serine/threonine kinase 1	Homo sapiens	50-53
24283667-9	2014	RESULTS: Depletion of Rac1 by RNAi prevented epinephrine-induced VWF secretion.	Epinephrine	45-56	Rac family small GTPase 1	Homo sapiens	22-26
24283667-10	2014	Also, the Rac1 inhibitor EHT1864 reduced epinephrine-induced WPB release.	Epinephrine	41-52	Rac family small GTPase 1	Homo sapiens	10-14
24283667-12	2014	The PI3K inhibitor LY294002 reduced epinephrine-induced release of VWF.	Epinephrine	36-47	von Willebrand factor	Homo sapiens	67-70
24283667-13	2014	RNAi-mediated downregulation of PREX1 abolished epinephrine-induced but not thrombin-induced release of WPBs.	Epinephrine	48-59	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	Homo sapiens	32-37
24283667-14	2014	CONCLUSION: Our findings show that PREX1 regulates epinephrine-induced release of WPBs.	Epinephrine	51-62	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	Homo sapiens	35-40
24466223-10	2014	SDHx/VHL/EPAS1 associated cases had higher norepinephrine output (P = 0.03) and lower epinephrine output (P<0.001) compared to RET/NF1/H-RAS cases.	Epinephrine	46-57	endothelial PAS domain protein 1	Homo sapiens	9-14
23085509-5	2014	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is a co-factor for several aromatic amino acid mono-oxygenases and is rate-limiting for the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Epinephrine	304-314	interferon gamma	Homo sapiens	30-46
24114805-10	2014	Accordingly, the mutant alpha2B -AR increases the epinephrine-stimulated calcium signaling.	Epinephrine	50-61	adrenoceptor alpha 2B	Homo sapiens	24-35
25171187-0	2014	Epinephrine evokes renalase secretion via alpha-adrenoceptor/NF-kappaB pathways in renal proximal tubular epithelial cells.	Epinephrine	0-11	renalase, FAD dependent amine oxidase	Homo sapiens	19-27
25243125-5	2014	We also employed CD14 siRNA interference to investigate whether CD14 played a role in the mechanism underlying the effect of epinephrine on LPS-induced macrophage responses.	Epinephrine	125-136	CD14 molecule	Homo sapiens	64-68
25243125-5	2014	We also employed CD14 siRNA interference to investigate whether CD14 played a role in the mechanism underlying the effect of epinephrine on LPS-induced macrophage responses.	Epinephrine	125-136	interferon regulatory factor 6	Homo sapiens	140-143
25243125-6	2014	Our results showed that epinephrine pretreatment (10 ng/mL) significantly promoted immune responses from LPS stimulated macrophages, including phagocytic rate, phagocytic index, TNFalpha/IL-1beta/IL-10 secretion, and CD14 expression (P < 0.05).	Epinephrine	24-35	interferon regulatory factor 6	Homo sapiens	105-108
25243125-6	2014	Our results showed that epinephrine pretreatment (10 ng/mL) significantly promoted immune responses from LPS stimulated macrophages, including phagocytic rate, phagocytic index, TNFalpha/IL-1beta/IL-10 secretion, and CD14 expression (P < 0.05).	Epinephrine	24-35	tumor necrosis factor	Homo sapiens	178-186
25243125-6	2014	Our results showed that epinephrine pretreatment (10 ng/mL) significantly promoted immune responses from LPS stimulated macrophages, including phagocytic rate, phagocytic index, TNFalpha/IL-1beta/IL-10 secretion, and CD14 expression (P < 0.05).	Epinephrine	24-35	interleukin 1 beta	Homo sapiens	187-195
25243125-6	2014	Our results showed that epinephrine pretreatment (10 ng/mL) significantly promoted immune responses from LPS stimulated macrophages, including phagocytic rate, phagocytic index, TNFalpha/IL-1beta/IL-10 secretion, and CD14 expression (P < 0.05).	Epinephrine	24-35	interleukin 10	Homo sapiens	196-201
25243125-6	2014	Our results showed that epinephrine pretreatment (10 ng/mL) significantly promoted immune responses from LPS stimulated macrophages, including phagocytic rate, phagocytic index, TNFalpha/IL-1beta/IL-10 secretion, and CD14 expression (P < 0.05).	Epinephrine	24-35	CD14 molecule	Homo sapiens	217-221
24138638-2	2014	Activation of brain CB1 receptors inhibited the secretion of adrenal catecholamines (noradrenaline and adrenaline) induced by i.c.v.	Epinephrine	88-98	cannabinoid receptor 1	Rattus norvegicus	20-23
25486571-0	2014	The induction of thioredoxin-1 by epinephrine withdraws stress via interaction with beta-arrestin-1.	Epinephrine	34-45	thioredoxin 1	Rattus norvegicus	17-30
25486571-0	2014	The induction of thioredoxin-1 by epinephrine withdraws stress via interaction with beta-arrestin-1.	Epinephrine	34-45	arrestin, beta 1	Rattus norvegicus	84-99
25486571-4	2014	Thus, it is important to examine whether Trx-1 is induced by epinephrine and to understand the underlying molecular mechanisms that Trx-1 modulates epinephrine stress.	Epinephrine	61-72	thioredoxin 1	Mus musculus	41-46
25486571-4	2014	Thus, it is important to examine whether Trx-1 is induced by epinephrine and to understand the underlying molecular mechanisms that Trx-1 modulates epinephrine stress.	Epinephrine	148-159	thioredoxin 1	Mus musculus	132-137
25486571-5	2014	Here, we show that the expression of Trx-1 was induced by epinephrine via beta-adrenergic receptor/Cyclic AMP/protein kinase A (PKA) signaling pathway in PC12 cells.	Epinephrine	58-69	thioredoxin 1	Mus musculus	37-42
25486571-8	2014	Moreover, Trx-1 overexpression reduced the malondialdehyde concentration by epinephrine.	Epinephrine	76-87	thioredoxin 1	Mus musculus	10-15
25230230-4	2014	This reaction is considered as rate-limiting step in the biosynthesis of catecholamines, dopamine, norepinephrine and epinephrine, which has made TH an important target for drug development.	Epinephrine	102-113	tyrosine hydroxylase	Homo sapiens	146-148
25035978-6	2014	Furthermore, adrenaline-induced up-regulation of HS 6-O-sulfotransferase-1 (6-OST-1) was controlled by Src-ERK1/2 signaling pathway.	Epinephrine	13-23	heparan sulfate 6-O-sulfotransferase 1	Mus musculus	76-83
25035978-6	2014	Furthermore, adrenaline-induced up-regulation of HS 6-O-sulfotransferase-1 (6-OST-1) was controlled by Src-ERK1/2 signaling pathway.	Epinephrine	13-23	Rous sarcoma oncogene	Mus musculus	103-106
25035978-6	2014	Furthermore, adrenaline-induced up-regulation of HS 6-O-sulfotransferase-1 (6-OST-1) was controlled by Src-ERK1/2 signaling pathway.	Epinephrine	13-23	mitogen-activated protein kinase 3	Mus musculus	107-113
25035978-7	2014	Finally, inhibiting the signaling pathways for 6-OST-1 intentionally suppressed the adrenaline-induced structural alteration of HS.	Epinephrine	84-94	heparan sulfate 6-O-sulfotransferase 1	Mus musculus	47-54
24642449-5	2014	However, the copresence of LPS and either epinephrine or norepinephrine resulted in a strong M2 phenotype including high levels of arginase-1 and interleukin-10, and a reduced expression of M1 markers.	Epinephrine	42-53	arginase, liver	Mus musculus	131-141
24642449-5	2014	However, the copresence of LPS and either epinephrine or norepinephrine resulted in a strong M2 phenotype including high levels of arginase-1 and interleukin-10, and a reduced expression of M1 markers.	Epinephrine	42-53	interleukin 10	Mus musculus	146-160
25171187-4	2014	The purpose of this study is to investigate whether renalase expression is induced by epinephrine via alpha-adrenoceptor/NFkappaB pathways.	Epinephrine	86-97	renalase, FAD dependent amine oxidase	Homo sapiens	52-60
25171187-4	2014	The purpose of this study is to investigate whether renalase expression is induced by epinephrine via alpha-adrenoceptor/NFkappaB pathways.	Epinephrine	86-97	nuclear factor kappa B subunit 1	Homo sapiens	121-129
25171187-5	2014	METHODS: HK2 cells were utilized to explore renalase expression in response to epinephrine in vitro.	Epinephrine	79-90	renalase, FAD dependent amine oxidase	Homo sapiens	44-52
25171187-8	2014	RESULTS: Both protein and mRNA levels of renalase in HK2 cells increased in response to epinephrine (P<0.05).	Epinephrine	88-99	renalase, FAD dependent amine oxidase	Homo sapiens	41-49
25171187-9	2014	Epinephrine-evoked renalase expression was attenuated by phentolamine and TPCK separately (P<0.05).	Epinephrine	0-11	renalase, FAD dependent amine oxidase	Homo sapiens	19-27
25171187-10	2014	CONCLUSION: Epinephrine evokes renalase secretion via alpha-adrenoceptor/NF-kappaB pathways in renal proximal tubular epithelial cells.	Epinephrine	12-23	renalase, FAD dependent amine oxidase	Homo sapiens	31-39
24396707-1	2013	Phenylethanolamine n-methyltransferase (Pnmt) catalyzes the conversion of norepinephrine into epinephrine, and thus serves as a marker of adrenergic cells.	Epinephrine	77-88	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
24366986-1	2014	OBJECTIVE: Vitamin B12 is involved in the production of adrenaline from noradrenaline.	Epinephrine	56-66	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	19-22
24396707-1	2013	Phenylethanolamine n-methyltransferase (Pnmt) catalyzes the conversion of norepinephrine into epinephrine, and thus serves as a marker of adrenergic cells.	Epinephrine	77-88	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
24453831-2	2013	Platelet Function Analyzer (PFA-100) with Collagen/Epinephrine (CEPI) is sensitive to functional alterations of VWF and also identifies patients with high on-treatment platelet reactivity (HPR).	Epinephrine	51-62	von Willebrand factor	Homo sapiens	112-115
24138817-9	2013	In normothermia experiments epinephrine in contrast to Levosimendan increased cTnI phosphorylation 3.5-fold.	Epinephrine	28-39	troponin I3, cardiac type	Rattus norvegicus	78-82
24103449-12	2013	Leptin increased day 1 and epinephrine at all times after ozone.	Epinephrine	27-38	leptin	Rattus norvegicus	0-6
24169047-9	2013	In isolated EDL, epinephrine reduced the basal UPS activity and suppressed overall proteolysis and atrogin-1 and MuRF1 induction following fasting.	Epinephrine	17-28	F-box protein 32	Rattus norvegicus	99-108
24169047-9	2013	In isolated EDL, epinephrine reduced the basal UPS activity and suppressed overall proteolysis and atrogin-1 and MuRF1 induction following fasting.	Epinephrine	17-28	tripartite motif containing 63	Rattus norvegicus	113-118
24142945-1	2013	BET 3: do doctors know how to use adrenaline autoinjectors correctly?	Epinephrine	34-44	trafficking protein particle complex subunit 3	Homo sapiens	0-5
24052031-3	2013	Furthermore, epinephrine increases IL-6 secretion from skeletal muscle, suggesting that IL-6 could play a role in mediating the lipolytic effects of catecholamines.	Epinephrine	13-24	interleukin 6	Mus musculus	35-39
24052031-3	2013	Furthermore, epinephrine increases IL-6 secretion from skeletal muscle, suggesting that IL-6 could play a role in mediating the lipolytic effects of catecholamines.	Epinephrine	13-24	interleukin 6	Mus musculus	88-92
24052031-4	2013	The purpose of this study was to determine whether IL-6 stimulates skeletal muscle lipolysis in a fiber type dependent manner and is required for epinephrine-stimulated lipolysis in murine skeletal muscle.	Epinephrine	146-157	interleukin 6	Mus musculus	51-55
24173134-10	2013	Vasopressin effect remained at 15-20 mmHg after three doses versus zero with adrenaline or placebo.	Epinephrine	77-87	vasopressin	Sus scrofa	0-11
24256680-12	2013	However, the largest increase was noted in PMNs exposed to ADSC culture supernatants that had been cocultured with stress levels of adrenaline for 12 hours, twofold increase in CD11b expression and fourfold increase in superoxide anion and percent elastase release.	Epinephrine	132-142	integrin subunit alpha M	Homo sapiens	177-182
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Epinephrine	77-88	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Epinephrine	77-88	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Epinephrine	93-103	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
24018397-1	2013	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine (noradrenaline) to epinephrine (adrenaline) while, concomitantly, S-adenosyl-L-methionine (AdoMet) is converted to S-adenosyl-L-homocysteine.	Epinephrine	93-103	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
23833052-11	2013	Our data suggest that physical activity-induced increases in nitric oxide interact with adrenaline and ANP to trigger the induction of NPR and betaAR mRNAs in the RP adipose tissue depot of the OLETF rat.	Epinephrine	88-98	neuronal pentraxin receptor	Rattus norvegicus	135-138
24071464-12	2013	Similarly, low ATP concentrations potentiated epinephrine-induced platelet aggregation that was abolished by P2Y1 antagonist MRS2500 suggesting P2Y1 receptor activation due to contaminating ADP.	Epinephrine	46-57	purinergic receptor P2Y1	Homo sapiens	109-113
24071464-12	2013	Similarly, low ATP concentrations potentiated epinephrine-induced platelet aggregation that was abolished by P2Y1 antagonist MRS2500 suggesting P2Y1 receptor activation due to contaminating ADP.	Epinephrine	46-57	purinergic receptor P2Y1	Homo sapiens	144-157
24071464-14	2013	CONCLUSION: Thus, the data demonstrate nucleoside triphosphates in general act as P2Y12 receptor antagonists and antagonise ADP-, collagen-, and epinephrine-induced platelet aggregation.	Epinephrine	145-156	purinergic receptor P2Y12	Homo sapiens	82-87
24056936-0	2013	Adrenaline-activated structure of beta2-adrenoceptor stabilized by an engineered nanobody.	Epinephrine	0-10	adrenoceptor beta 2	Homo sapiens	34-52
24056936-4	2013	Many natural agonists such as adrenaline, which activates the beta2-adrenoceptor (beta2AR), bind with relatively low affinity, and they are often chemically unstable.	Epinephrine	30-40	adrenoceptor beta 2	Homo sapiens	62-80
24056936-4	2013	Many natural agonists such as adrenaline, which activates the beta2-adrenoceptor (beta2AR), bind with relatively low affinity, and they are often chemically unstable.	Epinephrine	30-40	adrenoceptor beta 2	Homo sapiens	82-89
24056936-6	2013	Here we present structures of the active-state human beta2AR bound to three chemically distinct agonists: the ultrahigh-affinity agonist BI167107, the high-affinity catecholamine agonist hydroxybenzyl isoproterenol, and the low-affinity endogenous agonist adrenaline.	Epinephrine	256-266	adrenoceptor beta 2	Homo sapiens	53-60
24138817-10	2013	After rewarming from DHCA, cTnI phosphorylation increased 4.5-fold in the saline and epinephrine group compared to normothermia but remained unchanged with levosimendan.	Epinephrine	85-96	troponin I3, cardiac type	Rattus norvegicus	27-31
24056772-4	2013	Furthermore, although mice with endothelial-specific deletion of Atg7 have normal vessel architecture and capillary density, they exhibit impaired epinephrine-stimulated VWF release, reduced levels of high-molecular weight VWF multimers and a corresponding prolongation of bleeding times.	Epinephrine	147-158	autophagy related 7	Mus musculus	65-69
24064875-8	2013	RESULTS: We found that vasopressin (p = 0.005) and epinephrine (p = 0.01) increased significantly with injury, while angiotensin (p = 0.60) and cortisol (p = 0.46) did not and that vasopressin (p < 0.001) and epinephrine (p = 0.004) increased significantly in patients requiring transfusion of more than 600 mL but angiotensin II (p = 0.11) and cortisol (p = 0.90) did not.	Epinephrine	212-223	arginine vasopressin	Homo sapiens	23-34
24056772-4	2013	Furthermore, although mice with endothelial-specific deletion of Atg7 have normal vessel architecture and capillary density, they exhibit impaired epinephrine-stimulated VWF release, reduced levels of high-molecular weight VWF multimers and a corresponding prolongation of bleeding times.	Epinephrine	147-158	Von Willebrand factor	Mus musculus	170-173
23774690-1	2013	Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine.	Epinephrine	67-77	catechol-O-methyltransferase	Homo sapiens	0-28
23964689-3	2013	While it has been widely reported that renalase is the third monoamine oxidase (monoamine oxidase C) that oxidizes circulating catecholamines such as epinephrine, there has been no convincing demonstration of this catalysis in vitro.	Epinephrine	150-161	renalase, FAD dependent amine oxidase	Homo sapiens	39-47
23964689-3	2013	While it has been widely reported that renalase is the third monoamine oxidase (monoamine oxidase C) that oxidizes circulating catecholamines such as epinephrine, there has been no convincing demonstration of this catalysis in vitro.	Epinephrine	150-161	renalase, FAD dependent amine oxidase	Homo sapiens	80-99
23774690-1	2013	Catechol-O-methyltransferase (COMT) inactivates the catecholamines adrenaline, noradrenaline and dopamine.	Epinephrine	67-77	catechol-O-methyltransferase	Homo sapiens	30-34
23921203-10	2013	Multiple endocrine neoplasia type 2- and NF1-related PCC samples exhibited both adrenaline and noradrenaline secretion.	Epinephrine	80-90	neurofibromin 1	Homo sapiens	41-44
23564017-13	2013	Clenbuterol, and high concentrations of adrenaline and BRL37344 direct the beta2-adrenoceptor partly to Galphai, possibly mediated by beta2-adrenoceptor phosphorylation.	Epinephrine	40-50	adrenergic receptor, beta 2	Mus musculus	75-93
23564017-13	2013	Clenbuterol, and high concentrations of adrenaline and BRL37344 direct the beta2-adrenoceptor partly to Galphai, possibly mediated by beta2-adrenoceptor phosphorylation.	Epinephrine	40-50	adrenergic receptor, beta 2	Mus musculus	134-152
23806036-3	2013	Dopamine-beta-hydroxylase (DBH) is the crucial enzyme for NE and epinephrine biosynthesis.	Epinephrine	65-76	dopamine beta-hydroxylase	Rattus norvegicus	0-25
23806036-3	2013	Dopamine-beta-hydroxylase (DBH) is the crucial enzyme for NE and epinephrine biosynthesis.	Epinephrine	65-76	dopamine beta-hydroxylase	Rattus norvegicus	27-30
22694845-3	2013	LAT gel (lidocaine, adrenaline, and tetracaine) is a topical anaesthetic, which is ideal for suturing facial lacerations in children.	Epinephrine	20-30	linker for activation of T cells	Homo sapiens	0-3
23967086-6	2013	In vitro studies using primary hepatocyte cultures treated with epinephrine or AR-agonists confirmed that hepatic AR/cAMP/PKA/CREB- and JNK-linked pathways are involved in PPARalpha and HNF4alpha regulation.	Epinephrine	64-75	cAMP responsive element binding protein 1	Mus musculus	126-130
23817588-0	2013	An electrochemiluminescence sensor for adrenaline assay based on the tyrosinase/SiC/chitosan modified electrode.	Epinephrine	39-49	tyrosinase	Homo sapiens	69-79
23817588-1	2013	An electrochemiluminescence sensor for adrenaline based on a tyrosinase/SiC/chitosan film modified glassy carbon electrode was fabricated, and the proposed sensor showed high sensitivity and excellent biocompatibility.	Epinephrine	39-49	tyrosinase	Homo sapiens	61-71
23967086-6	2013	In vitro studies using primary hepatocyte cultures treated with epinephrine or AR-agonists confirmed that hepatic AR/cAMP/PKA/CREB- and JNK-linked pathways are involved in PPARalpha and HNF4alpha regulation.	Epinephrine	64-75	mitogen-activated protein kinase 8	Mus musculus	136-139
23967086-6	2013	In vitro studies using primary hepatocyte cultures treated with epinephrine or AR-agonists confirmed that hepatic AR/cAMP/PKA/CREB- and JNK-linked pathways are involved in PPARalpha and HNF4alpha regulation.	Epinephrine	64-75	peroxisome proliferator activated receptor alpha	Mus musculus	172-181
23967086-6	2013	In vitro studies using primary hepatocyte cultures treated with epinephrine or AR-agonists confirmed that hepatic AR/cAMP/PKA/CREB- and JNK-linked pathways are involved in PPARalpha and HNF4alpha regulation.	Epinephrine	64-75	hepatic nuclear factor 4, alpha	Mus musculus	186-195
23860985-1	2013	IMPORTANCE: Among patients with cardiac arrest, preliminary data have shown improved return of spontaneous circulation and survival to hospital discharge with the vasopressin-steroids-epinephrine (VSE) combination.	Epinephrine	184-195	arginine vasopressin	Homo sapiens	163-174
23786226-1	2013	BACKGROUND: The beta-2 adrenergic receptor (ADRB2) is an important target for epinephrine, a neurotransmitter in pain signalling.	Epinephrine	78-89	adrenoceptor beta 2	Homo sapiens	16-42
23786226-1	2013	BACKGROUND: The beta-2 adrenergic receptor (ADRB2) is an important target for epinephrine, a neurotransmitter in pain signalling.	Epinephrine	78-89	adrenoceptor beta 2	Homo sapiens	44-49
23643240-11	2013	When a reaction appears as "possible anaphylaxis," it is generally better to err on the side of caution and administer epinephrine.	Epinephrine	119-130	solute carrier family 7 member 1	Homo sapiens	77-80
23860985-12	2013	CONCLUSION AND RELEVANCE: Among patients with cardiac arrest requiring vasopressors, combined vasopressin-epinephrine and methylprednisolone during CPR and stress-dose hydrocortisone in postresuscitation shock, compared with epinephrine/saline placebo, resulted in improved survival to hospital discharge with favorable neurological status.	Epinephrine	106-117	arginine vasopressin	Homo sapiens	94-105
23860985-12	2013	CONCLUSION AND RELEVANCE: Among patients with cardiac arrest requiring vasopressors, combined vasopressin-epinephrine and methylprednisolone during CPR and stress-dose hydrocortisone in postresuscitation shock, compared with epinephrine/saline placebo, resulted in improved survival to hospital discharge with favorable neurological status.	Epinephrine	225-236	arginine vasopressin	Homo sapiens	94-105
23772221-14	2013	In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR.	Epinephrine	125-136	adrenoceptor alpha 2C	Rattus norvegicus	26-35
23688565-10	2013	Compared with the epinephrine group, less myocardial and mitochondrial injury was observed by electron microscopy in the CDP-choline and placebo groups; the level of superoxide dismutase and malondialdehyde indicated less peroxidative injury in the CDP-choline and placebo groups.	Epinephrine	18-29	cut-like homeobox 1	Rattus norvegicus	121-124
23211751-5	2013	Furthermore, adrenaline significantly reduced the expression of chemokine CXCL8_L1 (a functional homolog of mammalian IL-8) and its receptors (CXCR1 and CXCR2), indicating changes in leukocyte recruitment after stress.	Epinephrine	13-23	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
23211751-5	2013	Furthermore, adrenaline significantly reduced the expression of chemokine CXCL8_L1 (a functional homolog of mammalian IL-8) and its receptors (CXCR1 and CXCR2), indicating changes in leukocyte recruitment after stress.	Epinephrine	13-23	C-X-C motif chemokine receptor 1	Homo sapiens	143-148
23211751-5	2013	Furthermore, adrenaline significantly reduced the expression of chemokine CXCL8_L1 (a functional homolog of mammalian IL-8) and its receptors (CXCR1 and CXCR2), indicating changes in leukocyte recruitment after stress.	Epinephrine	13-23	C-X-C motif chemokine receptor 2	Homo sapiens	153-158
23772221-14	2013	In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR.	Epinephrine	125-136	angiotensin II receptor, type 1a	Rattus norvegicus	51-55
23772221-14	2013	In conclusion, peripheral alpha2CAR-stimulation or AT1R-inhibition restored failing alpha2AAR-mediated auto-inhibition of norepinephrine and epinephrine release and control of TPR in SHR.	Epinephrine	125-136	adrenoceptor alpha 2A	Rattus norvegicus	84-93
23489141-4	2013	The effects of (-)-noradrenaline, mediated through beta1 adrenoceptors (beta2 adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2 adrenoceptors (beta1 adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of PDE inhibitors.	Epinephrine	121-135	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	154-159
23489141-4	2013	The effects of (-)-noradrenaline, mediated through beta1 adrenoceptors (beta2 adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2 adrenoceptors (beta1 adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of PDE inhibitors.	Epinephrine	121-135	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	175-180
23489141-11	2013	Concurrent therapy with a PDE3 blocker and metoprolol could conceivably facilitate cardiostimulation evoked by adrenaline through beta2 adrenoceptors.	Epinephrine	111-121	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	130-135
23682023-0	2013	3T3-L1 adipocytes possess anandamide- and epinephrine-responsive machinery for MDM2 distribution to the plasma membrane.	Epinephrine	42-53	MDM2 proto-oncogene	Homo sapiens	79-83
23837045-2	2013	We also investigated the effects of epinephrine on ANGPTL2 expression in adipocytes in vitro.	Epinephrine	36-47	angiopoietin like 2	Homo sapiens	51-58
23837045-6	2013	Epinephrine reduced the ANGPTL2 mRNA and protein levels in differentiated 3T3-L1 adipocytes in a dose-dependent manner.	Epinephrine	0-11	angiopoietin like 2	Homo sapiens	24-31
23682023-2	2013	We examined MDM2 level in the plasma membrane (PM) and total MDM2 level of 3T3-L1 adipocytes treated with biomolecular anandamide, epinephrine, and other agents for 15 min.	Epinephrine	131-142	MDM2 proto-oncogene	Homo sapiens	12-16
23515286-8	2013	Metoprolol treatment and ghrelin treatment in KO mice prevented excessive sympathetic activation, decreased plasma epinephrine and norepinephrine levels, and improved heart function and survival rate after MI.	Epinephrine	115-126	ghrelin	Mus musculus	25-32
23724117-10	2013	RESULTS: TLR9-induced IFNA1 secretion as well as TLR4-induced TNF secretion from PBMCs was dose-dependently attenuated by coincubation with epinephrine.	Epinephrine	140-151	toll like receptor 4	Homo sapiens	49-53
23724117-10	2013	RESULTS: TLR9-induced IFNA1 secretion as well as TLR4-induced TNF secretion from PBMCs was dose-dependently attenuated by coincubation with epinephrine.	Epinephrine	140-151	tumor necrosis factor	Homo sapiens	62-65
22706789-3	2013	Specifically, we generated a reporter mouse strain in which a nuclear-localized enhanced green fluorescent protein gene (nEGFP) was inserted into exon 1 of the gene encoding Phenylethanolamine n-methyltransferase (Pnmt), the enzyme responsible for production of adrenaline from noradrenaline.	Epinephrine	262-272	phenylethanolamine-N-methyltransferase	Mus musculus	174-212
22706789-3	2013	Specifically, we generated a reporter mouse strain in which a nuclear-localized enhanced green fluorescent protein gene (nEGFP) was inserted into exon 1 of the gene encoding Phenylethanolamine n-methyltransferase (Pnmt), the enzyme responsible for production of adrenaline from noradrenaline.	Epinephrine	262-272	phenylethanolamine-N-methyltransferase	Mus musculus	214-218
23724117-10	2013	RESULTS: TLR9-induced IFNA1 secretion as well as TLR4-induced TNF secretion from PBMCs was dose-dependently attenuated by coincubation with epinephrine.	Epinephrine	140-151	toll like receptor 9	Homo sapiens	9-13
23724117-10	2013	RESULTS: TLR9-induced IFNA1 secretion as well as TLR4-induced TNF secretion from PBMCs was dose-dependently attenuated by coincubation with epinephrine.	Epinephrine	140-151	interferon alpha 1	Homo sapiens	22-27
23536322-2	2013	The complexes NaK-Ni7-Ale2 (Ale = [H2O3PC(C3H6NH2)(OH)PO3H2]) and NaNH4-Ni7-Ale2 are both made of two {PW9O34} fragments enclosing a heptanuclear Ni(II) core connected to two alendronate ligands.	Epinephrine	22-25	TANK binding kinase 1	Homo sapiens	14-17
23276607-6	2013	PFC tissue from ACTH pre-treated animals contained significantly higher serotonin, noradrenaline and adrenaline concentrations relative to saline pre-treated controls.	Epinephrine	86-96	proopiomelanocortin	Homo sapiens	16-20
22999161-3	2013	Therefore, our aim was to investigate whether splenic T- and B-cells are one of main sources in the spleen expressing tyrosine hydroxylase (TH), enzyme crucial for CA biosynthesis, and phenylethanolamine N-methyltransferase (PNMT) which is necessary for epinephrine production.	Epinephrine	254-265	tyrosine hydroxylase	Homo sapiens	118-138
23225249-0	2013	D-chiro-inositol attenuates epinephrine-stimulated hepatic glucose output in the isolated perfused liver independently of insulin.	Epinephrine	28-39	enoyl-CoA delta isomerase 1	Rattus norvegicus	0-16
23225249-5	2013	We found that perfusion with 200 muM DCI attenuated epinephrine-stimulated HGO by 35% over 30 min as compared to the buffer control perfusion (p=0.05).	Epinephrine	52-63	enoyl-CoA delta isomerase 1	Rattus norvegicus	37-40
23395072-5	2013	RESULTS: During stable peak gene expression on days 5 to 7, HCN2/SkM1 LBB-injected dogs showed highly stable in vivo pacemaker activity superior to SkM1 or HCN2 alone and superior to LV-implanted dogs with regard to beating rates (resting approximately 80 beats/min; maximum approximately 130 beats/min), no dependence on electronic backup pacing, and enhanced modulation of pacemaker function during circadian rhythm or epinephrine infusion.	Epinephrine	421-432	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2	Canis lupus familiaris	60-64
23356740-7	2013	Conversely, the structurally related receptor, CG16766, was internalized by a number of biogenic amines, including octopamine, dopamine, noradrenaline, adrenaline, which also were able to elevate cyclic AMP levels.	Epinephrine	140-150	Tyramine receptor II	Drosophila melanogaster	47-54
23364786-3	2013	It is well established that alpha1A-ARs are less phosphorylated, desensitized, and internalized on exposure to the phenethylamines norepinephrine (NE), epinephrine, or phenylephrine (PE) than are the alpha1B and alpha1D subtypes.	Epinephrine	134-145	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	28-35
23455217-3	2013	This study shows the down regulation of adrenergic receptors due to chronic use of lisinopril, an ACE inhibitor as a cause of poor response of adrenaline.	Epinephrine	143-153	angiotensin I converting enzyme	Homo sapiens	98-101
23283360-10	2013	Correlates of insulin resistance in SS were mean arterial pressure, epinephrine, and norepinephrine, all remaining as significant predictors in multivariate modeling.	Epinephrine	68-79	insulin	Homo sapiens	14-21
23046406-7	2013	Activation of alpha1A by epinephrine in donor cells led to dose-dependent calcium increases in recipient cells, which were detected by measuring the intensity of aequorin luminescence.	Epinephrine	25-36	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	14-21
23413305-1	2013	BET 1: the use of adrenaline and long-term survival in cardiopulmonary resuscitation following cardiac arrest.	Epinephrine	18-28	Bet1 golgi vesicular membrane trafficking protein	Homo sapiens	0-5
22998365-6	2013	The BAX expression in epinephrine resuscitated and 100% oxygen resuscitated groups were found to be upregulated in the brain regions.	Epinephrine	22-33	BCL2 associated X, apoptosis regulator	Rattus norvegicus	4-7
23433357-9	2013	RESULTS: Circulating noradrenaline and adrenaline correlated weakly but independently with syndecan-1 (rho = 0.15 and rho = 0.13, both P <0.01) and thrombomodulin (rho = 0.11 and rho = 0.17, both P <0.01), biomarkers of glycocalyx and endothelial cell damage, respectively.	Epinephrine	24-34	syndecan 1	Homo sapiens	91-101
23433357-9	2013	RESULTS: Circulating noradrenaline and adrenaline correlated weakly but independently with syndecan-1 (rho = 0.15 and rho = 0.13, both P <0.01) and thrombomodulin (rho = 0.11 and rho = 0.17, both P <0.01), biomarkers of glycocalyx and endothelial cell damage, respectively.	Epinephrine	24-34	thrombomodulin	Homo sapiens	151-165
23204390-2	2013	The first potent beta2AR agonist discovered and widely used in reversing the airway constriction associated with asthma exacerbation was the endogenous activator of the beta2AR, epinephrine.	Epinephrine	178-189	adrenergic receptor, beta 2	Mus musculus	17-24
23204390-2	2013	The first potent beta2AR agonist discovered and widely used in reversing the airway constriction associated with asthma exacerbation was the endogenous activator of the beta2AR, epinephrine.	Epinephrine	178-189	adrenergic receptor, beta 2	Mus musculus	169-176
23204390-3	2013	In this study, we demonstrate that activation of the beta2AR by epinephrine is paradoxically required for development of the asthma phenotype.	Epinephrine	64-75	adrenergic receptor, beta 2	Mus musculus	53-60
23290307-0	2013	Bisoprolol reverses epinephrine-mediated inhibition of cell emigration through increases in the expression of beta-arrestin 2 and CCR7 and PI3K phosphorylation, in dendritic cells loaded with cholesterol.	Epinephrine	20-31	arrestin beta 2	Homo sapiens	110-125
23290307-0	2013	Bisoprolol reverses epinephrine-mediated inhibition of cell emigration through increases in the expression of beta-arrestin 2 and CCR7 and PI3K phosphorylation, in dendritic cells loaded with cholesterol.	Epinephrine	20-31	C-C motif chemokine receptor 7	Homo sapiens	130-134
23290307-4	2013	In cholesterol-loaded DCs, treatment with epinephrine significantly increased AR-beta1 protein expression by 56.99+-4.87%, but inhibited beta-arrestin 2 and CCR7 protein expression by 30.51+-4.22% and 25.31+-0.04%, respectively.	Epinephrine	42-53	arrestin beta 2	Homo sapiens	137-152
23290307-4	2013	In cholesterol-loaded DCs, treatment with epinephrine significantly increased AR-beta1 protein expression by 56.99+-4.87%, but inhibited beta-arrestin 2 and CCR7 protein expression by 30.51+-4.22% and 25.31+-0.04%, respectively.	Epinephrine	42-53	C-C motif chemokine receptor 7	Homo sapiens	157-161
23290307-6	2013	TNF-alpha and MMP9 levels were decreased by 68.33+-4.00% and 39.57+-9.21% in cholesterol-loaded DCs treated with epinephrine.	Epinephrine	113-124	tumor necrosis factor	Homo sapiens	0-9
23290307-6	2013	TNF-alpha and MMP9 levels were decreased by 68.33+-4.00% and 39.57+-9.21% in cholesterol-loaded DCs treated with epinephrine.	Epinephrine	113-124	matrix metallopeptidase 9	Homo sapiens	14-18
23224622-0	2013	Double stable isotope ultra performance liquid chromatographic-tandem mass spectrometric quantification of tissue content and activity of phenylethanolamine N-methyltransferase, the crucial enzyme responsible for synthesis of epinephrine.	Epinephrine	226-237	phenylethanolamine N-methyltransferase	Homo sapiens	138-176
23224622-1	2013	Here, we describe a novel method utilizing double stable isotope ultra performance liquid chromatography-tandem mass spectrometry to measure tissue contents and activity of phenylethanolamine N-methyltransferase (PNMT), the enzyme responsible for synthesis of the stress hormone, epinephrine.	Epinephrine	280-291	phenylethanolamine N-methyltransferase	Homo sapiens	173-211
23224622-1	2013	Here, we describe a novel method utilizing double stable isotope ultra performance liquid chromatography-tandem mass spectrometry to measure tissue contents and activity of phenylethanolamine N-methyltransferase (PNMT), the enzyme responsible for synthesis of the stress hormone, epinephrine.	Epinephrine	280-291	phenylethanolamine N-methyltransferase	Homo sapiens	213-217
23224622-5	2013	The calibration curve relating PNMT to production of deuterium-labeled epinephrine was also linear from 0.01 to 100 ng PNMT.	Epinephrine	71-82	phenylethanolamine N-methyltransferase	Homo sapiens	31-35
23224622-5	2013	The calibration curve relating PNMT to production of deuterium-labeled epinephrine was also linear from 0.01 to 100 ng PNMT.	Epinephrine	71-82	phenylethanolamine N-methyltransferase	Homo sapiens	119-123
23224622-8	2013	Development of this assay provides new possibilities for investigations focusing on regulation of PNMT, the crucial final enzyme responsible for synthesis of epinephrine, the primary fight-or-flight stress hormone.	Epinephrine	158-169	phenylethanolamine N-methyltransferase	Homo sapiens	98-102
23005263-3	2013	EXPERIMENTAL APPROACH: rho-Da1a was tested as an antagonist of adrenaline-induced effects on COS cells transfected with the human alpha(1)             (A) -adrenoceptor as well as on human isolated prostatic adenoma obtained from patients suffering from benign prostatic hyperplasia.	Epinephrine	63-73	adrenoceptor alpha 1A	Homo sapiens	130-168
23201424-0	2013	Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments.	Epinephrine	0-11	cAMP responsive element binding protein 1	Rattus norvegicus	50-54
23201424-12	2013	Epinephrine and glucose attenuated age-related deficits in CREB phosphorylation, but were more effective in the amygdala and hippocampus, respectively.	Epinephrine	0-11	cAMP responsive element binding protein 1	Rattus norvegicus	59-63
23201424-13	2013	Together, these results support the view that age-related changes in blood glucose responses to epinephrine contribute to memory impairments, which may be related to alterations in regional patterns of CREB phosphorylation.	Epinephrine	96-107	cAMP responsive element binding protein 1	Rattus norvegicus	202-206
23280413-1	2013	Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation.	Epinephrine	124-135	catechol-O-methyltransferase	Homo sapiens	0-28
22290536-8	2013	In addition, enhanced IL-6 promoter activity can be similarly induced by ET-1 and catecholamines (epinephrine and norepinephrine).	Epinephrine	98-109	interleukin 6	Mus musculus	22-26
22290536-11	2013	Furthermore, injection of mice with epinephrine and ET-1 induced a tremendously synergistic increase in serum IL-6 levels.	Epinephrine	36-47	interleukin 6	Mus musculus	110-114
23280413-1	2013	Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation.	Epinephrine	124-135	catechol-O-methyltransferase	Homo sapiens	30-34
23290933-10	2013	These results suggest that systemic epinephrine, perhaps by evoking central norepinephrine release, modulated the increase in the forebrain GABA(A) receptor recruitment induced by both insulin and stress in different ways depending on the subpopulation fearfulness.	Epinephrine	36-47	insulin	Homo sapiens	185-192
23231070-5	2013	More recently, AI-3 and the host neuroendocrine (NE) hormones adrenaline and noradrenaline were reported to display cross-talk for the activation of the same signalling pathways.	Epinephrine	62-72	family with sequence similarity 83 member H	Homo sapiens	15-19
23175689-4	2013	Pyk2-deficient mice were also significantly protected from collagen plus epinephrine-induced pulmonary thromboembolism.	Epinephrine	73-84	PTK2 protein tyrosine kinase 2 beta	Mus musculus	0-4
21785110-7	2012	One hour after TAC, CB1 KO mice had significant larger lung weight to body weight ratio (LW/BW, 14.53 + 1.09 mg/g in KO vs. 10.42 + 0.36 mg/g in WT, P < 0.01) and higher plasma epinephrine levels (9720 + 1226 pg/mL vs. 6378 + 832 pg/mL, P < 0.05).	Epinephrine	180-191	cannabinoid receptor 1 (brain)	Mus musculus	20-23
23648158-10	2013	The plasma contents of Cyt C and caspase-3 in the epinephrine group and the anisodamine group gradually increased after ROSC, and were significantly higher than those in the control group.	Epinephrine	50-61	cytochrome c	Sus scrofa	23-28
23648158-10	2013	The plasma contents of Cyt C and caspase-3 in the epinephrine group and the anisodamine group gradually increased after ROSC, and were significantly higher than those in the control group.	Epinephrine	50-61	caspase 3	Sus scrofa	33-42
24450388-1	2013	Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine.	Epinephrine	193-204	catechol-O-methyltransferase	Homo sapiens	0-28
24450388-1	2013	Catechol-O-methyltransferase (COMT) is the enzyme which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine and norepinephrine.	Epinephrine	193-204	catechol-O-methyltransferase	Homo sapiens	30-34
24348034-0	2013	Biosensor based on tyrosinase immobilized on a single-walled carbon nanotube-modified glassy carbon electrode for detection of epinephrine.	Epinephrine	127-138	tyrosinase	Homo sapiens	19-29
24348034-3	2013	Tyrosinase maintained high bioactivity on this nanomaterial, catalyzing the oxidation of epinephrine to epinephrine-quinone, which was electrochemically reduced (-0.07 V versus Ag/AgCl) on the biosensor surface.	Epinephrine	89-100	tyrosinase	Homo sapiens	0-10
24025788-6	2013	In addition, after 7 weeks of treatment with D-PA, the change between systolic blood pressure before and after sympathetic stimulation (Delta-SBP) by L-epinephrine was about 2.5-fold larger than that in the control group.	Epinephrine	150-163	spermine binding protein	Rattus norvegicus	142-145
23375328-1	2013	INTRODUCTION: Renalase, an enzyme that cetabolyzes catecholamines, such as circulating adrenaline and noradrenaline, is released by the human kidney to regulate blood pressure.	Epinephrine	87-97	renalase, FAD dependent amine oxidase	Homo sapiens	14-22
21898033-6	2012	The present study aims to examine the association between three common BDNF single-nucleotid polymorphisms (SNPs; rs7103411, rs7124442, and rs6265) and depressive symptoms in a community-based elderly population taking into account the serum levels of four neurotransmitters, serotonin, dopamine, adrenalin, and noradrenalin, as potential mediating factors.	Epinephrine	297-306	brain derived neurotrophic factor	Homo sapiens	71-75
23027532-7	2012	The expressions of the sipA and sopB genes, involved in the invasion of epithelial cells, are activated by epinephrine via QseE.	Epinephrine	107-118	plasmid-partitioning protein	Salmonella enterica subsp. enterica serovar Typhimurium	32-36
24054138-1	2013	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Epinephrine	109-119	tyrosine hydroxylase	Homo sapiens	0-20
24054138-1	2013	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Epinephrine	109-119	tyrosine hydroxylase	Homo sapiens	22-24
23546002-4	2013	In this work, we address the influence of lipid composition on the structural stability of GPCR, performing molecular dynamics simulations of three kinds of states: apo-, and agonist epinephrine-, or antagonist alprenolol-bound beta2AR.	Epinephrine	183-194	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	91-95
23546002-7	2013	The distances between Lys267(6.29) and Asp331(7.58) of apo- and alprenolol-bound beta2ARs are smaller than that of the epinephrine-bound beta2AR.	Epinephrine	119-130	adrenoceptor beta 2	Homo sapiens	81-88
23224606-0	2013	Adrenaline administration promotes the efficiency of granulocyte colony stimulating factor-mediated hematopoietic stem and progenitor cell mobilization in mice.	Epinephrine	0-10	colony stimulating factor 3 (granulocyte)	Mus musculus	53-90
23224606-8	2013	The combined use of adrenaline and G-CSF not only accelerated HSPC mobilization, but also enabled the efficient mobilization of HSPCs into the peripheral blood at lower doses of G-CSF.	Epinephrine	20-30	colony stimulating factor 3 (granulocyte)	Mus musculus	178-183
23224606-9	2013	Adrenaline/G-CSF treatment also extensively downregulated levels of SDF-1 and CXCR4 in mouse bone marrow.	Epinephrine	0-10	colony stimulating factor 3 (granulocyte)	Mus musculus	11-16
23224606-9	2013	Adrenaline/G-CSF treatment also extensively downregulated levels of SDF-1 and CXCR4 in mouse bone marrow.	Epinephrine	0-10	chemokine (C-X-C motif) ligand 12	Mus musculus	68-73
23224606-9	2013	Adrenaline/G-CSF treatment also extensively downregulated levels of SDF-1 and CXCR4 in mouse bone marrow.	Epinephrine	0-10	chemokine (C-X-C motif) receptor 4	Mus musculus	78-83
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	32-42	chemokine (C-X-C motif) receptor 4	Mus musculus	115-120
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	32-42	chemokine (C-X-C motif) ligand 12	Mus musculus	121-126
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	32-42	colony stimulating factor 3 (granulocyte)	Mus musculus	225-230
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	32-42	colony stimulating factor 3 (granulocyte)	Mus musculus	225-230
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	160-170	colony stimulating factor 3 (granulocyte)	Mus musculus	57-62
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	160-170	chemokine (C-X-C motif) receptor 4	Mus musculus	115-120
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	160-170	chemokine (C-X-C motif) ligand 12	Mus musculus	121-126
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	160-170	colony stimulating factor 3 (granulocyte)	Mus musculus	225-230
23224606-10	2013	These results demonstrated that adrenaline combined with G-CSF can induce HSPC mobilization by down-regulating the CXCR4/SDF-1 axis, indicating that the use of adrenaline may enable the use of reduced dosages or durations of G-CSF treatment, minimizing G-CSF-associated complications.	Epinephrine	160-170	colony stimulating factor 3 (granulocyte)	Mus musculus	225-230
23105094-8	2012	Interestingly, the Ser-364 allele (detected in ~15% subjects) was strongly associated with profound reduction (up to ~2.1-fold) in plasma norepinephrine/epinephrine levels consistent with the diminished nAChR desensitization-blocking effect of CST-Ser-364 as compared with CST-WT.	Epinephrine	141-152	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	203-208
23022135-7	2012	Epinephrine-stimulated melanosome trafficking was delayed in the Inpp5e zebrafish morphants.	Epinephrine	0-11	inositol polyphosphate-5-phosphatase E	Danio rerio	65-71
23010500-10	2012	Moreover, during adrenaline infusion the leptin release from leg skeletal muscle was strongly suppressed (20.5 +- 7.9 ng min(-1), p<0.017), whereas the release from fat was unaltered.	Epinephrine	17-27	leptin	Homo sapiens	41-47
23010500-10	2012	Moreover, during adrenaline infusion the leptin release from leg skeletal muscle was strongly suppressed (20.5 +- 7.9 ng min(-1), p<0.017), whereas the release from fat was unaltered.	Epinephrine	17-27	CD59 molecule (CD59 blood group)	Homo sapiens	121-127
23134102-6	2012	In comparison, only 21 pharmacists (21/38; 55.3%) agreed to administer an adrenaline auto-injector (Epi-Pen) for a child experiencing an anaphylaxis, with nine respondents (9/38; 23.7%) indicating that they would ask the mother for directions in a situation where they were unsure how to administer it.	Epinephrine	74-84	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	104-107
23162530-16	2012	alpha(2A)AR inhibited epinephrine secretion, particularly in SHR.	Epinephrine	22-33	adrenoceptor alpha 2A	Rattus norvegicus	0-11
23036199-0	2012	Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155.	Epinephrine	0-10	microRNA 155	Homo sapiens	117-124
23036199-3	2012	Further study found that adrenaline increased miR-155 expression in an NFkappaB dependent manner.	Epinephrine	25-35	microRNA 155	Homo sapiens	46-53
22778220-6	2012	Through physiological assays, we demonstrated that the decrease of Pax6 affects specifically acute glucagon secretion in primary alpha-cell in response to glucose, palmitate, and glucose-dependent insulinotropic peptide (GIP) but not the response to arginine and epinephrine.	Epinephrine	263-274	paired box 6	Mus musculus	67-71
22917559-5	2012	Further analyses using tropolone, a catechol O-methyltransferase (COMT) inhibitor, indicated that one of the two [(35)S]sulfated metabolites of dopamine, epinephrine, isoproterenol, and isoetharine was a doubly conjugated (methylated and sulfated) product, since its level decreased proportionately with increasing concentrations of tropolone added to the labeling media.	Epinephrine	154-165	catechol-O-methyltransferase	Homo sapiens	36-64
22917559-5	2012	Further analyses using tropolone, a catechol O-methyltransferase (COMT) inhibitor, indicated that one of the two [(35)S]sulfated metabolites of dopamine, epinephrine, isoproterenol, and isoetharine was a doubly conjugated (methylated and sulfated) product, since its level decreased proportionately with increasing concentrations of tropolone added to the labeling media.	Epinephrine	154-165	catechol-O-methyltransferase	Homo sapiens	66-70
22917559-7	2012	A two-stage enzymatic assay showed the sequential methylation and sulfation of dopamine, epinephrine, isoproterenol, and isoetharine mediated by, respectively, the COMT and the cytosolic sulfotransferase SULT1A3.	Epinephrine	89-100	catechol-O-methyltransferase	Homo sapiens	164-168
22917559-7	2012	A two-stage enzymatic assay showed the sequential methylation and sulfation of dopamine, epinephrine, isoproterenol, and isoetharine mediated by, respectively, the COMT and the cytosolic sulfotransferase SULT1A3.	Epinephrine	89-100	sulfotransferase family 1A member 3	Homo sapiens	204-211
22796071-3	2012	GRK2 AS-ODN administration led to an enhanced and prolonged hyperalgesia induced by prostaglandin E(2), epinephrine and carrageenan.	Epinephrine	104-115	G protein-coupled receptor kinase 2	Rattus norvegicus	0-4
23205094-5	2012	Epinephrine, norepinephrine and isoproterenol increased the cellular proliferation of the rat OS cell line COS1NR and rat MSCs in a dose-dependent and beta2AR antagonist-sensitive manner.	Epinephrine	0-11	adrenoceptor beta 2	Rattus norvegicus	151-158
23289294-0	2012	[Intensity of cardiac free-radicals processes and expression of glutathione peroxidase and glutathione reductase genes in rats with adrenaline].	Epinephrine	132-142	glutathione-disulfide reductase	Rattus norvegicus	91-112
23107895-8	2012	Here we provide a detailed review of renalase biology including its mechanism of action, secretion into blood, interaction with the renal dopamine and epinephrine system, and early studies evaluating its association with outcomes related to hypertension and target-organ injury.	Epinephrine	151-162	renalase, FAD dependent amine oxidase	Homo sapiens	37-45
22996798-2	2012	CE with LIF detection for the determination of FITC derivatized catecholamines (dopamine, epinephrine, and norepinephrine) was demonstrated.	Epinephrine	90-101	LIF, interleukin 6 family cytokine	Rattus norvegicus	8-11
22659252-4	2012	The findings indicated that plasma IL-12 levels were significantly reduced by social confrontation, wet-cage exposure, surgery, and the administration of corticosterone, epinephrine, or prostaglandin-E(2).	Epinephrine	170-181	interleukin 12B	Rattus norvegicus	35-40
22617505-10	2012	CRP positively correlated with the doses of the epinephrine and norepinephrine and the monocyte counts, and negatively correlated with the lymphocyte count.	Epinephrine	48-59	C-reactive protein	Homo sapiens	0-3
22863277-6	2012	In contrast, stimulation of Gs-coupled receptors by glucagon or epinephrine activates Lats1/2 kinase activity, thereby inhibiting YAP function.	Epinephrine	64-75	large tumor suppressor kinase 1	Homo sapiens	86-91
22863277-6	2012	In contrast, stimulation of Gs-coupled receptors by glucagon or epinephrine activates Lats1/2 kinase activity, thereby inhibiting YAP function.	Epinephrine	64-75	Yes1 associated transcriptional regulator	Homo sapiens	130-133
22732314-4	2012	We hypothesized that this represents switching of epinephrine signaling through the pleiotropic beta(2)-adrenergic receptor (beta(2)AR) from canonical stimulatory G-protein-activated cardiostimulant to inhibitory G-protein-activated cardiodepressant pathways.	Epinephrine	50-61	adrenoceptor beta 2	Rattus norvegicus	96-123
22732314-4	2012	We hypothesized that this represents switching of epinephrine signaling through the pleiotropic beta(2)-adrenergic receptor (beta(2)AR) from canonical stimulatory G-protein-activated cardiostimulant to inhibitory G-protein-activated cardiodepressant pathways.	Epinephrine	50-61	adrenoceptor beta 2	Rattus norvegicus	125-134
22732314-7	2012	beta(2)AR number and functional responses were greater in isolated apical cardiomyocytes than in basal cardiomyocytes, which confirmed the higher apical sensitivity and response to circulating epinephrine.	Epinephrine	193-204	adrenoceptor beta 2	Rattus norvegicus	0-9
22732314-8	2012	In vitro studies demonstrated high-dose epinephrine can induce direct cardiomyocyte cardiodepression and cardioprotection in a beta(2)AR-Gi-dependent manner.	Epinephrine	40-51	adrenoceptor beta 2	Rattus norvegicus	127-136
22732314-9	2012	Preventing epinephrine-G(i) effects increased mortality in the Takotsubo model, whereas beta-blockers that activate beta(2)AR-G(i) exacerbated the epinephrine-dependent negative inotropic effects without further deaths.	Epinephrine	147-158	adrenoceptor beta 2	Rattus norvegicus	116-125
22732314-11	2012	CONCLUSIONS: We suggest that biased agonism of epinephrine for beta(2)AR-G(s) at low concentrations and for G(i) at high concentrations underpins the acute apical cardiodepression observed in Takotsubo cardiomyopathy, with an apical-basal gradient in beta(2)ARs explaining the differential regional responses.	Epinephrine	47-58	adrenoceptor beta 2	Rattus norvegicus	63-72
22659252-6	2012	The IL-12-reducing effects of wet-cage exposure, and of corticosterone and epinephrine administration, were significantly greater in males than in females, although females exhibited greater total corticosterone levels following stress.	Epinephrine	75-86	interleukin 12B	Rattus norvegicus	4-9
23130169-0	2012	Renalase lowers ambulatory blood pressure by metabolizing circulating adrenaline.	Epinephrine	70-80	renalase, FAD dependent amine oxidase	Homo sapiens	0-8
22766618-9	2012	The use of several inotropes or vasopressor such as vasopressin is proposed in case of reactions refractory to epinephrine and volume expansion.	Epinephrine	111-122	arginine vasopressin	Homo sapiens	52-63
23130169-5	2012	METHODS AND RESULTS: Using in vitro enzymatic assays and in vivo administration of recombinant renalase, we show that the protein functions as a flavin adenine dinucleotide- and nicotinamide adenine dinucleotide-dependent oxidase that lowers blood pressure by degrading plasma epinephrine.	Epinephrine	277-288	renalase, FAD dependent amine oxidase	Homo sapiens	95-103
23130169-7	2012	To test if epinephrine and l-3,4-dihydroxyphenylalanine were renalase"s only substrates, 17 246 unique small molecules were screened.	Epinephrine	11-22	renalase, FAD dependent amine oxidase	Homo sapiens	61-69
23130169-11	2012	CONCLUSIONS: Renalase metabolizes circulating epinephrine and l-3,4-dihydroxyphenylalanine, and its capacity to decrease blood pressure is directly correlated to its enzymatic activity.	Epinephrine	46-57	renalase, FAD dependent amine oxidase	Homo sapiens	13-21
22090159-1	2012	Epinephrine (Epi), which initiates short-term responses to cope with stress, is, in part, stress-regulated via genetic control of its biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Rattus norvegicus	155-193
22511766-4	2012	Epinephrine stimulation of endothelial cells leads to Rap1 activation in a PKA-independent fashion.	Epinephrine	0-11	RAP1A, member of RAS oncogene family	Homo sapiens	54-58
22511766-5	2012	siRNA-mediated knockdown of Epac1 abolished epinephrine-induced activation of Rap1 and resulted in decreased epinephrine-induced WPB exocytosis.	Epinephrine	44-55	Rap guanine nucleotide exchange factor 3	Homo sapiens	28-33
22511766-5	2012	siRNA-mediated knockdown of Epac1 abolished epinephrine-induced activation of Rap1 and resulted in decreased epinephrine-induced WPB exocytosis.	Epinephrine	44-55	RAP1A, member of RAS oncogene family	Homo sapiens	78-82
22511766-5	2012	siRNA-mediated knockdown of Epac1 abolished epinephrine-induced activation of Rap1 and resulted in decreased epinephrine-induced WPB exocytosis.	Epinephrine	109-120	Rap guanine nucleotide exchange factor 3	Homo sapiens	28-33
22511766-6	2012	Down-regulation of Rap1 expression and prevention of Rap1 activation through overexpression of Rap1GAP effectively reduced epinephrine- but not thrombin-induced WPB exocytosis.	Epinephrine	123-134	RAP1A, member of RAS oncogene family	Homo sapiens	19-23
22511766-6	2012	Down-regulation of Rap1 expression and prevention of Rap1 activation through overexpression of Rap1GAP effectively reduced epinephrine- but not thrombin-induced WPB exocytosis.	Epinephrine	123-134	RAP1A, member of RAS oncogene family	Homo sapiens	53-57
22511766-6	2012	Down-regulation of Rap1 expression and prevention of Rap1 activation through overexpression of Rap1GAP effectively reduced epinephrine- but not thrombin-induced WPB exocytosis.	Epinephrine	123-134	RAP1 GTPase activating protein	Homo sapiens	95-102
22510709-5	2012	The primary effectors of the stress system, glucocorticoids and epinephrine, highly induced CYP3A1/2.	Epinephrine	64-75	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	92-100
22510709-6	2012	Epinephrine also induced the expression of CYP2C11 and CYP2D1/2.	Epinephrine	0-11	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	43-50
22510709-6	2012	Epinephrine also induced the expression of CYP2C11 and CYP2D1/2.	Epinephrine	0-11	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	55-63
22866043-4	2012	Limited evidence exists for positive effects of HAI on: reduction of stress-related parameters such as epinephrine and norepinephrine; improvement of immune system functioning and pain management; increased trustworthiness of and trust toward other persons; reduced aggression; enhanced empathy and improved learning.	Epinephrine	103-114	serine peptidase inhibitor, Kunitz type 1	Homo sapiens	48-51
22090159-1	2012	Epinephrine (Epi), which initiates short-term responses to cope with stress, is, in part, stress-regulated via genetic control of its biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Rattus norvegicus	195-199
22864036-6	2012	DBP was decreased at 5 minutes after epinephrine administration in the epinephrine group and increased at 10 and 15 minutes but there was no significant differences between the two groups.	Epinephrine	37-48	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
22864036-6	2012	DBP was decreased at 5 minutes after epinephrine administration in the epinephrine group and increased at 10 and 15 minutes but there was no significant differences between the two groups.	Epinephrine	71-82	D-box binding PAR bZIP transcription factor	Homo sapiens	0-3
22280801-5	2012	Preincubation with orexin-A or orexin-B reduced the adrenaline-, histamine- or serotonin-induced oxytocin level increases, but the oxytocin concentrations of the supernatant media remained above the control level.	Epinephrine	52-62	hypocretin neuropeptide precursor	Rattus norvegicus	19-27
22483297-1	2012	The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE).	Epinephrine	129-140	catechol-O-methyltransferase	Homo sapiens	11-39
22483297-1	2012	The enzyme catechol-O-methyltransferase (COMT) has been shown to play a critical role in pain perception by regulating levels of epinephrine (Epi) and norepinephrine (NE).	Epinephrine	129-140	catechol-O-methyltransferase	Homo sapiens	41-45
22173970-11	2012	Additionally, epinephrine promoted LNCaP cell survival through activation of AKT that was insensitive to STO-609.	Epinephrine	14-25	AKT serine/threonine kinase 1	Homo sapiens	77-80
22754515-8	2012	The final study used double immunohistochemistry labeling of c-fos and dopamine beta hydroxylase (DBH), the enzyme for norepinephrine synthesis to determine if epinephrine administration alone or stimulation of the vagus nerve at an intensity identical to that which improved memory in Experiment 1 produces similar patterns of neuronal activity in brain areas involved in processing memory for emotional events.	Epinephrine	122-133	dopamine beta-hydroxylase	Homo sapiens	98-101
22496244-5	2012	Despite blunted increases in p38 phosphorylation, the ability of epinephrine to induce PGC-1alpha was intact in skeletal muscle from HFD-fed rats and was associated with normal increases in activation of PKA and phosphorylation of cAMP response element-binding protein, reputed mediators of PGC-1alpha expression.	Epinephrine	65-76	PPARG coactivator 1 alpha	Rattus norvegicus	87-97
22496244-5	2012	Despite blunted increases in p38 phosphorylation, the ability of epinephrine to induce PGC-1alpha was intact in skeletal muscle from HFD-fed rats and was associated with normal increases in activation of PKA and phosphorylation of cAMP response element-binding protein, reputed mediators of PGC-1alpha expression.	Epinephrine	65-76	PPARG coactivator 1 alpha	Rattus norvegicus	291-301
22496244-6	2012	The attenuated epinephrine-mediated increase in p38 phosphorylation was independent of increases in MAPK phosphatase 1.	Epinephrine	15-26	mitogen activated protein kinase 14	Rattus norvegicus	48-51
22465165-5	2012	Twenty min after leptin treatment, there were higher plasma concentrations of noradrenaline, but not adrenaline, in comparison with the saline-treated control group.	Epinephrine	81-91	leptin	Rattus norvegicus	17-23
22664332-9	2012	The ratios of noradrenaline and adrenaline to dopamine in the brain were also increased by the treatment, suggesting that dopamine beta-hydroxylase activity was improved by the combination therapy.	Epinephrine	17-27	dopamine beta hydroxylase	Mus musculus	122-147
22460068-0	2012	Effect of epinephrine on platelet-activating factor-stimulated human vascular smooth muscle cells.	Epinephrine	10-21	PCNA clamp associated factor	Homo sapiens	25-51
22460068-3	2012	In particular, the effect of the timing of epinephrine administration on the action of PAF has not been examined.	Epinephrine	43-54	PCNA clamp associated factor	Homo sapiens	87-90
22460068-4	2012	OBJECTIVE: Using human vascular smooth muscle cells (HVSMCs), we examined the effect of timing of epinephrine addition on the action of PAF.	Epinephrine	98-109	PCNA clamp associated factor	Homo sapiens	136-139
22460068-5	2012	METHODS: The effect of epinephrine on PAF-mediated prostaglandin E(2) (PGE(2)) release from human aortic smooth muscle cells was examined.	Epinephrine	23-34	PCNA clamp associated factor	Homo sapiens	38-41
22460068-8	2012	Whereas preincubation of HVSMCs with epinephrine before the addition of PAF suppressed PGE(2) release, treatment with epinephrine after PAF stimulation was less effective with time after PAF stimulation.	Epinephrine	118-129	PCNA clamp associated factor	Homo sapiens	136-139
22460068-8	2012	Whereas preincubation of HVSMCs with epinephrine before the addition of PAF suppressed PGE(2) release, treatment with epinephrine after PAF stimulation was less effective with time after PAF stimulation.	Epinephrine	118-129	PCNA clamp associated factor	Homo sapiens	136-139
22460068-10	2012	CONCLUSIONS: PAF induced PGE(2) release from HVSMCs in a concentration- and time-dependent manner, and early addition of epinephrine was essential for the control of PAF-induced PGE(2) release.	Epinephrine	121-132	PCNA clamp associated factor	Homo sapiens	166-169
22460068-11	2012	Epinephrine was most effective when administered before stimulation with PAF but was progressively less effective with time after PAF stimulation.	Epinephrine	0-11	PCNA clamp associated factor	Homo sapiens	73-76
22460068-11	2012	Epinephrine was most effective when administered before stimulation with PAF but was progressively less effective with time after PAF stimulation.	Epinephrine	0-11	PCNA clamp associated factor	Homo sapiens	130-133
21926666-0	2012	Vasopressin rescue for in-pediatric intensive care unit cardiopulmonary arrest refractory to initial epinephrine dosing: a prospective feasibility pilot trial.	Epinephrine	101-112	arginine vasopressin	Homo sapiens	0-11
21926666-1	2012	OBJECTIVES: To assess the feasibility of a large, randomized controlled trial of combination epinephrine-arginine vasopressin for in-pediatric intensive care unit cardiopulmonary arrest refractory to initial epinephrine dosing.	Epinephrine	93-104	arginine vasopressin	Homo sapiens	114-125
22280801-5	2012	Preincubation with orexin-A or orexin-B reduced the adrenaline-, histamine- or serotonin-induced oxytocin level increases, but the oxytocin concentrations of the supernatant media remained above the control level.	Epinephrine	52-62	hypocretin neuropeptide precursor	Rattus norvegicus	19-25
22093677-0	2012	Association of plasma epinephrine level with insulin sensitivity in metabolically healthy but obese individuals.	Epinephrine	22-33	insulin	Homo sapiens	45-52
22351773-7	2012	Accordingly, myonectin transcript was up-regulated by compounds (forskolin, epinephrine, ionomycin) that raise cellular cAMP or calcium levels.	Epinephrine	76-87	erythroferrone	Mus musculus	13-22
22093677-5	2012	The plasma epinephrine level was positively correlated with the glucose disposal rate, insulin sensitivity and the HDL-cholesterol level, and negatively correlated with the triglycerides level (P<0.05).	Epinephrine	11-22	insulin	Homo sapiens	87-94
22093677-6	2012	In conclusion, this study for the first time demonstrates a positive association between plasma epinephrine level and insulin sensitivity in MHO individuals.	Epinephrine	96-107	insulin	Homo sapiens	118-125
22508204-6	2012	Adrenaline (mean dose: 0.06 mug/kg x min-1) was required in seven patients from Group B but in none of the Group A patients on initial separation from CPB (P< 0.05).	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	37-42
22298778-6	2012	Epinephrine stimulated subplasmalemmal translocation of STIM1 in alpha-cells and retranslocation in beta-cells involving raising and lowering of cAMP, respectively.	Epinephrine	0-11	stromal interaction molecule 1	Homo sapiens	56-61
22326747-2	2012	As the only route in the catecholamine biosynthetic pathway, Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine.	Epinephrine	134-145	phenylethanolamine N-methyltransferase	Homo sapiens	61-99
22326747-2	2012	As the only route in the catecholamine biosynthetic pathway, Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine.	Epinephrine	134-145	phenylethanolamine N-methyltransferase	Homo sapiens	101-105
22452847-4	2012	In the present study, the relevance of the PKA activity and two PKA-activating drugs, aminophylline and adrenaline, to LPS-induced inflammatory cytokines (IL-6 and IL-8) and PGE2 by HGFs were examined.	Epinephrine	104-114	interleukin 6	Homo sapiens	155-159
22452847-4	2012	In the present study, the relevance of the PKA activity and two PKA-activating drugs, aminophylline and adrenaline, to LPS-induced inflammatory cytokines (IL-6 and IL-8) and PGE2 by HGFs were examined.	Epinephrine	104-114	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
21851339-2	2012	Inactivation of AMPK by adrenaline was through both alpha1- and beta-ARs (adrenergic receptors), but did not involve cAMP or calcium signalling, was not blocked by the PKC (protein kinase C) inhibitor BIM I (bisindoylmaleimide I), by the ERK (extracellular-signal-regulated kinase) cascade inhibitor U0126 or by PTX (pertussis toxin).	Epinephrine	24-34	Eph receptor B1	Rattus norvegicus	238-241
21851339-2	2012	Inactivation of AMPK by adrenaline was through both alpha1- and beta-ARs (adrenergic receptors), but did not involve cAMP or calcium signalling, was not blocked by the PKC (protein kinase C) inhibitor BIM I (bisindoylmaleimide I), by the ERK (extracellular-signal-regulated kinase) cascade inhibitor U0126 or by PTX (pertussis toxin).	Epinephrine	24-34	Eph receptor B1	Rattus norvegicus	243-280
22241475-5	2012	The second group comprised adrenaline and noradrenaline which displayed higher intrinsic activity for the ERK phosphorylation than for the cAMP response.	Epinephrine	27-37	mitogen-activated protein kinase 1	Homo sapiens	106-109
22168310-7	2012	Postoperative CRP positively correlated with epinephrine dosage and CPB duration.	Epinephrine	45-56	C-reactive protein	Homo sapiens	14-17
22404936-0	2012	Epinephrine modulates BCAM/Lu and ICAM-4 expression on the sickle cell trait red blood cell membrane.	Epinephrine	0-11	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	22-26
22404936-0	2012	Epinephrine modulates BCAM/Lu and ICAM-4 expression on the sickle cell trait red blood cell membrane.	Epinephrine	0-11	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	34-40
22124970-3	2012	Acute epinephrine infusion increases cardiac output and induces insulin resistance, but removal of the adrenal medulla has no consistent effect on blood pressure.	Epinephrine	6-17	insulin	Homo sapiens	64-71
22147898-5	2012	beta(2)-adrenergic receptor stimulation by epinephrine can enhance ERK1/2 activity only in SS RBCs via PKA- and tyrosine kinase p72(syk)-dependent pathways.	Epinephrine	43-54	mitogen-activated protein kinase 3	Homo sapiens	67-73
22147898-5	2012	beta(2)-adrenergic receptor stimulation by epinephrine can enhance ERK1/2 activity only in SS RBCs via PKA- and tyrosine kinase p72(syk)-dependent pathways.	Epinephrine	43-54	DEAD-box helicase 17	Homo sapiens	128-131
22147898-7	2012	SS RBC adhesion and phosphorylation of both ERK and ICAM-4 all decreased with continued cell exposure to epinephrine, implying that activation of ICAM-4-mediated SS RBC adhesion is temporally associated with ERK1/2 activation.	Epinephrine	105-116	mitogen-activated protein kinase 1	Homo sapiens	44-47
22147898-7	2012	SS RBC adhesion and phosphorylation of both ERK and ICAM-4 all decreased with continued cell exposure to epinephrine, implying that activation of ICAM-4-mediated SS RBC adhesion is temporally associated with ERK1/2 activation.	Epinephrine	105-116	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	52-58
22147898-7	2012	SS RBC adhesion and phosphorylation of both ERK and ICAM-4 all decreased with continued cell exposure to epinephrine, implying that activation of ICAM-4-mediated SS RBC adhesion is temporally associated with ERK1/2 activation.	Epinephrine	105-116	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	146-152
22147898-7	2012	SS RBC adhesion and phosphorylation of both ERK and ICAM-4 all decreased with continued cell exposure to epinephrine, implying that activation of ICAM-4-mediated SS RBC adhesion is temporally associated with ERK1/2 activation.	Epinephrine	105-116	mitogen-activated protein kinase 3	Homo sapiens	208-214
24527275-12	2012	Topical administration of inhibitors of cortisol synthesis, statins, beta2AR antagonists, and systemic beta-blockers can decrease cortisol synthesis, FPP, and epinephrine levels, respectively, thus restoring keratinocyte migration capacity.	Epinephrine	159-170	adrenoceptor beta 2	Homo sapiens	69-76
22124970-4	2012	Epinephrine is the most effective endogenous agonist at the beta2 receptor.	Epinephrine	0-11	hemoglobin, beta adult minor chain	Mus musculus	60-65
22124970-14	2012	Chronic administration of epinephrine and other beta2 agonists improves cellular glucose uptake and metabolism.	Epinephrine	26-37	hemoglobin, beta adult minor chain	Mus musculus	48-53
21818153-0	2012	Epinephrine induces PDK4 mRNA expression in adipose tissue from obese, insulin resistant rats.	Epinephrine	0-11	pyruvate dehydrogenase kinase 4	Rattus norvegicus	20-24
21954897-6	2012	Epinephrine infusion induced arrhythmias in 3 (12%) RYR2-mutation carriers, 4 (36%) genetically undefined CPVT patients, and 1 (2%) unaffected family member.	Epinephrine	0-11	ryanodine receptor 2	Homo sapiens	52-56
22170706-8	2012	Subjects with an exercise-induced rise in beta-endorphin levels to above 25 pg/ml (n = 7) exhibited markedly reduced levels of plasma epinephrine and norepinephrine compared with control (2495 +- 306 vs. 4810 +- 617 pmol/liter and 1.9 +- 0.3 vs. 2.9 +- 0.4 nmol/liter, respectively, P < 0.01 for both).	Epinephrine	134-145	proopiomelanocortin	Homo sapiens	42-56
21818153-3	2012	We recently demonstrated that epinephrine increases PDK4 expression through p38 and peroxisome proliferator-activated receptor gamma (PPARgamma) dependent pathways in cultured adipose tissue from lean rats.	Epinephrine	30-41	pyruvate dehydrogenase kinase 4	Rattus norvegicus	52-56
21990378-2	2012	We recently demonstrated that chromogranins A and B each regulate the concentration of adrenaline in chromaffin granules and its exocytosis.	Epinephrine	87-97	chromogranin A	Mus musculus	30-51
21818153-3	2012	We recently demonstrated that epinephrine increases PDK4 expression through p38 and peroxisome proliferator-activated receptor gamma (PPARgamma) dependent pathways in cultured adipose tissue from lean rats.	Epinephrine	30-41	mitogen activated protein kinase 14	Rattus norvegicus	76-79
21818153-3	2012	We recently demonstrated that epinephrine increases PDK4 expression through p38 and peroxisome proliferator-activated receptor gamma (PPARgamma) dependent pathways in cultured adipose tissue from lean rats.	Epinephrine	30-41	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	84-132
21818153-3	2012	We recently demonstrated that epinephrine increases PDK4 expression through p38 and peroxisome proliferator-activated receptor gamma (PPARgamma) dependent pathways in cultured adipose tissue from lean rats.	Epinephrine	30-41	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	134-143
21818153-4	2012	The purpose of this study was to determine whether acute epinephrine treatment, in vivo, can induce PDK4 mRNA expression in adipose tissue from obese, insulin resistant rats and if the reputed signaling pathways mediating this effect are intact.	Epinephrine	57-68	pyruvate dehydrogenase kinase 4	Rattus norvegicus	100-104
22976316-4	2012	Among the tropolonato-Zn(II) complexes with various coordination modes, di(2-mercaptotropolonato)zinc(II) (ZT2) with the Zn(S(2)O(2)) coordination mode was found to exhibit the highest in vitro insulin-mimetic activity with respect to inhibition of free fatty acid (FFA) release and enhancement of glucose uptake in isolated rat adipocytes treated with adrenaline.	Epinephrine	353-363	zinc finger protein 125	Mus musculus	107-110
22327786-13	2012	Deletion of the alpha(2C) subtype leads to increased adrenaline secretion and has the potential to increase blood glucose levels via enhanced glycogenolysis.	Epinephrine	53-63	adrenergic receptor, alpha 2c	Mus musculus	16-24
23160220-6	2012	RESULTS: CD4+ T lymphocytes with TH RNAi expressed less TH mRNA and protein and synthesized less CAs including norepinephrine, epinephrine and dopamine than control cells with mock transfection.	Epinephrine	114-125	tyrosine hydroxylase	Mus musculus	33-35
22013013-9	2011	Epinephrine responses throughout hypoglycemia were significantly increased by 50% when the B2AR agonist was delivered to the VMH (P < 0.01) and suppressed by 32% with the B2AR antagonist (P < 0.05).	Epinephrine	0-11	adrenoceptor beta 2	Homo sapiens	91-95
22701542-9	2012	The delta (final-basal) log of serum FGF21, adjusted for BMI, showed a significant positive correlation with basal glucose (r = 0.23, p = 0.04), mean maximal heart rate (MHR) (r = 0.54, p<0.0001), mean METs (r = 0.40, p = 0.002), delta plasma epinephrine (r = 0.53, p<0.0001) and delta plasma FFAs (r = 0.35, p = 0.006).	Epinephrine	246-257	fibroblast growth factor 21	Homo sapiens	37-42
22369514-14	2011	We have found a paper that reports the partial dependence of the antiapoptotic effect of adrenaline on androgen receptor.	Epinephrine	89-99	androgen receptor	Homo sapiens	103-120
21900458-5	2011	TAL NaCl reabsorption is subject to exquisite control by hormones like vasopressin, parathyroid, glucagon, and adrenergic agonists (epinephrine and norepinephrine) that stimulate NaCl reabsorption.	Epinephrine	132-143	transaldolase 1	Homo sapiens	0-3
23056605-1	2012	Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine.	Epinephrine	82-93	catechol-O-methyltransferase	Homo sapiens	0-28
23056605-1	2012	Catechol-O-methyltransferase (COMT) degrades catecholamines, such as dopamine and epinephrine, by methylating them in the presence of a divalent metal cation (usually Mg(II)), and S-adenosyl-L-methionine.	Epinephrine	82-93	catechol-O-methyltransferase	Homo sapiens	30-34
22916251-4	2012	Our current data show that chronic exposure of PDAC cell lines Panc-1 (activating point mutations in K-ras) and BXPC-3 (no mutations in K-ras) in vitro to the stress neurotransmitter epinephrine at the concentration (15 nM) previously measured in the serum of mice exposed to social stress significantly increased proliferation and migration.	Epinephrine	183-194	pancreas protein 1	Mus musculus	63-69
22916251-4	2012	Our current data show that chronic exposure of PDAC cell lines Panc-1 (activating point mutations in K-ras) and BXPC-3 (no mutations in K-ras) in vitro to the stress neurotransmitter epinephrine at the concentration (15 nM) previously measured in the serum of mice exposed to social stress significantly increased proliferation and migration.	Epinephrine	183-194	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	101-106
22715381-5	2012	Expression of KLF2 abolished the perinuclear clustering of WPBs observed following stimulation with cAMP-raising agonists such as epinephrine.	Epinephrine	130-141	Kruppel like factor 2	Homo sapiens	14-18
22013013-9	2011	Epinephrine responses throughout hypoglycemia were significantly increased by 50% when the B2AR agonist was delivered to the VMH (P < 0.01) and suppressed by 32% with the B2AR antagonist (P < 0.05).	Epinephrine	0-11	adrenoceptor beta 2	Homo sapiens	174-178
22013013-12	2011	Indeed, the B1AR antagonist increased rather than decreased epinephrine release (P < 0.05).	Epinephrine	60-71	adrenoceptor beta 1	Homo sapiens	12-16
22172866-1	2011	INTRODUCTION: Renalase, an enzyme that breaks down catecholamines like adrenaline and noradrenaline in the blood circulation, was discovered in 2005.	Epinephrine	71-81	renalase, FAD dependent amine oxidase	Homo sapiens	14-22
21907406-4	2011	The vasopressin level substantially increased after epinephrine, norepinephrine, serotonin, histamine, dopamine or K(+) treatment.	Epinephrine	52-63	arginine vasopressin	Rattus norvegicus	4-15
21866188-1	2011	BACKGROUND: Phenylethanolamine N-methyltransferase gene (PNMT) catalyzes the synthesis of epinephrine and plays an important role in regulating cardiovascular function.	Epinephrine	90-101	phenylethanolamine N-methyltransferase	Homo sapiens	12-50
20547474-9	2011	The association of the two cell types may be particularly important in the amphibians and birds because like in mammals, the enzyme catalysing the methylation of noradrenaline to adrenaline, PNMT, is under the control of the steroid cortisol.	Epinephrine	165-175	phenylethanolamine N-methyltransferase	Homo sapiens	191-195
21866188-1	2011	BACKGROUND: Phenylethanolamine N-methyltransferase gene (PNMT) catalyzes the synthesis of epinephrine and plays an important role in regulating cardiovascular function.	Epinephrine	90-101	phenylethanolamine N-methyltransferase	Homo sapiens	57-61
22234076-8	2011	Although there was no retching or vomiting, 80% of patients presented with nausea and exhibited a significant increase in plasma levels of VP, adrenaline and noradrenaline after administration of VP analogue.	Epinephrine	143-153	arginine vasopressin	Homo sapiens	196-198
21643680-11	2011	PFA-100 epinephrine closure time was the most sensitive laboratory test for VWD diagnosis with a sensitivity of 85%, followed by VWF:RCo assay (73%).	Epinephrine	8-19	von Willebrand factor	Homo sapiens	76-79
21745490-9	2011	In 3T3-L1 adipocytes, dexamethasone and adrenaline both increased adipoR2 mRNA levels, but RU-486 reduced adipoR2 gene expression in vitro.	Epinephrine	40-50	adiponectin receptor 2	Rattus norvegicus	66-73
21700896-9	2011	An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1alpha, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.	Epinephrine	48-59	PPARG coactivator 1 alpha	Rattus norvegicus	100-110
21802403-9	2011	However, in contrast to ceruloplasmin, hephaestin was incapable of direct oxidation of adrenaline and dopamine implying a difference in biological substrate specificities between these two homologous ferroxidases.	Epinephrine	87-97	hephaestin	Homo sapiens	39-49
21536121-4	2011	In the present study, we examined the effects of noradrenaline and adrenaline, stress-related catecholamines, on IL-33 production by dendritic cells (DCs).	Epinephrine	52-62	interleukin 33	Mus musculus	113-118
21536121-7	2011	Noradrenaline or adrenaline dramatically enhanced IL-33 mRNA expression and its protein synthesis by DCs upon LPS stimulation.	Epinephrine	3-13	interleukin 33	Mus musculus	50-55
21708146-11	2011	The mechanism involved in both cases is that SAMe is required for the conversion of epinephrine from norepinephrine by phenylethanolamine methyltransferase (PNMT).	Epinephrine	84-95	phenylethanolamine-N-methyltransferase	Rattus norvegicus	119-155
21708146-11	2011	The mechanism involved in both cases is that SAMe is required for the conversion of epinephrine from norepinephrine by phenylethanolamine methyltransferase (PNMT).	Epinephrine	84-95	phenylethanolamine-N-methyltransferase	Rattus norvegicus	157-161
21858843-6	2011	Activity of secreted MMP-2 increased only after 6-h epinephrine treatment in both cell types.	Epinephrine	52-63	matrix metallopeptidase 2	Mus musculus	21-26
23926399-9	2011	Urinary adrenaline correlated positively with urinary GH (R=0.470, p=0.013) and urinary cortisol (R=0.522, p=0.004).	Epinephrine	8-18	growth hormone 1	Homo sapiens	54-56
21700896-9	2011	An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1alpha, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.	Epinephrine	48-59	lipin 1	Rattus norvegicus	123-129
21996211-1	2011	BACKGROUND: Renalase is an enzyme that catabolizes catecholamines such as adrenaline and noradrenaline in the circulation.	Epinephrine	74-84	renalase, FAD dependent amine oxidase	Homo sapiens	12-20
21700896-9	2011	An acute bout of exercise, AICAR treatment, and epinephrine injections increased the mRNA levels of PGC-1alpha, COXIV, and lipin1 independent of decreases in nuclear RIP140 protein.	Epinephrine	48-59	nuclear receptor interacting protein 1	Rattus norvegicus	166-172
21499675-10	2011	In HUVEC, adrenaline (epinephrine) significantly increased nuclear translocation of nuclear factor-kappaB (NF-kappaB) p65 and levels of adhesion molecules, effects that were abrogated following addition of SQ22536, a specific adenyl cyclase inhibitor.	Epinephrine	10-20	synaptotagmin 1	Rattus norvegicus	118-121
21561432-8	2011	Dobutamine, a member of this group, had 70% of the adrenaline (epinephrine) effect on arrestin via beta1-AR, but acted as a competitive antagonist of adrenaline via beta2-AR.	Epinephrine	51-61	adrenoceptor beta 1	Homo sapiens	99-107
21561432-8	2011	Dobutamine, a member of this group, had 70% of the adrenaline (epinephrine) effect on arrestin via beta1-AR, but acted as a competitive antagonist of adrenaline via beta2-AR.	Epinephrine	63-74	adrenoceptor beta 1	Homo sapiens	99-107
21651344-0	2011	Endothelin-1 attenuates the hemodynamic response to exogenous epinephrine in a porcine ischemic ventricular fibrillation cardiac arrest model.	Epinephrine	62-73	endothelin-1	Sus scrofa	0-12
21651344-1	2011	Endothelin-1 (ET-1) increases in the ischemically induced ventricular fibrillation (VF) swine model of cardiac arrest and affects outcome by potentially attenuating the hemodynamic response to epinephrine.	Epinephrine	193-204	endothelin-1	Sus scrofa	0-12
21651344-1	2011	Endothelin-1 (ET-1) increases in the ischemically induced ventricular fibrillation (VF) swine model of cardiac arrest and affects outcome by potentially attenuating the hemodynamic response to epinephrine.	Epinephrine	193-204	endothelin-1	Sus scrofa	14-18
21651344-6	2011	Bayesian multivariate logistic regression analysis compared peak ET-1 levels with the binary outcome of a positive coronary perfusion pressure response of >20 mmHg following epinephrine.	Epinephrine	177-188	endothelin-1	Sus scrofa	65-69
21651344-10	2011	ET-1 levels were inversely associated with epinephrine response with a median posterior odds ratio (OR) of a coronary perfusion pressure response of 0.72 (95% confidence interval [CI] 0.48-1.06) for each one-unit increase in ET-1 and a probability that the associated OR is <1 of 0.95.	Epinephrine	43-54	endothelin-1	Sus scrofa	0-4
21926888-4	2011	The purpose of this retrospective case series was to report successful return of spontaneous circulation after the rescue administration of vasopressin after prolonged CA and failure of conventional CPR, advanced life support, and epinephrine therapy in children.	Epinephrine	231-242	arginine vasopressin	Homo sapiens	140-151
21624100-1	2011	AIM: Adrenaline has widespread metabolic actions, including stimulation of lipolysis and induction of insulin resistance and hyperlactatemia.	Epinephrine	5-15	insulin	Homo sapiens	102-109
21624100-4	2011	Our study was designed to test the hypothesis that local placebo controlled leg perfusion with adrenaline directly increases local lactate release, stimulates lipolysis, induces insulin resistance and leaves protein metabolism unaffected.	Epinephrine	95-105	insulin	Homo sapiens	178-185
21624100-12	2011	CONCLUSION:   Adrenaline directly increases lactate release and lipolysis and inhibits insulin-stimulated glucose uptake in the perfused human leg.	Epinephrine	14-24	insulin	Homo sapiens	87-94
21499675-10	2011	In HUVEC, adrenaline (epinephrine) significantly increased nuclear translocation of nuclear factor-kappaB (NF-kappaB) p65 and levels of adhesion molecules, effects that were abrogated following addition of SQ22536, a specific adenyl cyclase inhibitor.	Epinephrine	22-33	synaptotagmin 1	Rattus norvegicus	118-121
21490253-6	2011	By using cultured HEK293 cells transfected with zebrafish betaARs, we demonstrated that stimulation with adrenaline or procaterol (a beta2AR agonist) resulted in an increase in intracellular cAMP levels in cells expressing any of the three zebrafish betaARs.	Epinephrine	105-115	adrenoceptor beta 2	Homo sapiens	133-140
21392105-9	2011	PEPs occurred in 40 of the 941 patients (4.25%), the incidence of pancreatitis tended to be higher in the control group (31/480, 6.45%) than in the epinephrine group (9/461, 1.95%) (P = 0.0086).	Epinephrine	148-159	leucine aminopeptidase 3	Homo sapiens	0-4
21565206-10	2011	Adrenaline also upregulated MMP-9 activity and PGE(2) release.	Epinephrine	0-10	matrix metallopeptidase 9	Homo sapiens	28-33
21565206-11	2011	Adrenaline stimulated HT-29 cell proliferation which was reversed by COX-2 inhibitor sc-236.	Epinephrine	0-10	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74
26610136-3	2011	PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease.	Epinephrine	36-47	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
26610136-3	2011	PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease.	Epinephrine	36-47	phenylethanolamine N-methyltransferase	Homo sapiens	97-101
26610136-3	2011	PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease.	Epinephrine	66-76	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
26610136-3	2011	PNMT catalyzes the conversion of norepinephrine into epinephrine (adrenaline), and inhibitors of PNMT are of potential therapeutic importance in Alzheimer"s and Parkinson"s disease.	Epinephrine	66-76	phenylethanolamine N-methyltransferase	Homo sapiens	97-101
21514055-0	2011	GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia.	Epinephrine	34-45	G protein-coupled receptor kinase 2	Mus musculus	0-4
21565206-12	2011	COX-2 inhibitor also reverted the action of adrenaline on VEGF expression and MMP-9 activity.	Epinephrine	44-54	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
21565206-12	2011	COX-2 inhibitor also reverted the action of adrenaline on VEGF expression and MMP-9 activity.	Epinephrine	44-54	vascular endothelial growth factor A	Homo sapiens	58-62
21565206-12	2011	COX-2 inhibitor also reverted the action of adrenaline on VEGF expression and MMP-9 activity.	Epinephrine	44-54	matrix metallopeptidase 9	Homo sapiens	78-83
21565206-16	2011	In addition, both antagonists also abrogated the stimulating actions of adrenaline on COX-2, VEGF expression, MMP-9 activity and PGE(2) release in HT-29 cells.	Epinephrine	72-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	86-91
21565206-16	2011	In addition, both antagonists also abrogated the stimulating actions of adrenaline on COX-2, VEGF expression, MMP-9 activity and PGE(2) release in HT-29 cells.	Epinephrine	72-82	vascular endothelial growth factor A	Homo sapiens	93-97
21565206-16	2011	In addition, both antagonists also abrogated the stimulating actions of adrenaline on COX-2, VEGF expression, MMP-9 activity and PGE(2) release in HT-29 cells.	Epinephrine	72-82	matrix metallopeptidase 9	Homo sapiens	110-115
21565206-17	2011	SIGNIFICANCE: These results suggest that adrenaline stimulates cell proliferation of HT-29 cells via both beta(1)- and beta(2)-adrenoceptors by a COX-2 dependent pathway.	Epinephrine	41-51	prostaglandin-endoperoxide synthase 2	Homo sapiens	146-151
21695287-1	2011	Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response.	Epinephrine	88-98	catechol-O-methyltransferase	Homo sapiens	0-28
21695287-1	2011	Catechol-O-methyltransferase (COMT) metabolizes catechol neurotransmitters dopamine, noradrenaline and adrenaline that are involved in various physiological functions including mood, cognition and stress response.	Epinephrine	88-98	catechol-O-methyltransferase	Homo sapiens	30-34
21366703-5	2011	The blockade of beta1- and beta2-adrenoceptors reversed the increase in fibroblast proliferation, ERK 1/2 phosphorylation, myofibroblastic differentiation and the reduction of collagen deposition induced by epinephrine.	Epinephrine	207-218	hemoglobin, beta adult major chain	Mus musculus	16-32
21366703-6	2011	In addition, the blockade of beta3-adrenoceptors reversed the increase in fibroblast proliferation and nitric oxide synthesis as well as the reduction of fibroblast migration, AKT phosphorylation and active matrix metalloproteinase-2 expression induced by epinephrine.	Epinephrine	256-267	matrix metallopeptidase 2	Mus musculus	207-233
21145823-2	2011	This study aimed at verifying the hypothesis that ablation of the ALE-receptor galectin-3 prevents experimental NASH by reducing receptor-mediated ALE clearance and downstream events.	Epinephrine	66-69	lectin, galactose binding, soluble 3	Mus musculus	79-89
21145823-10	2011	CONCLUSIONS: Galectin-3 ablation protects from diet-induced NASH by decreasing hepatic ALE accumulation, with attenuation of inflammation, hepatocyte injury, and fibrosis.	Epinephrine	87-90	lectin, galactose binding, soluble 3	Mus musculus	13-23
21145823-12	2011	These data suggest that galectin-3 is a major receptor involved in ALE uptake by the liver.	Epinephrine	67-70	lectin, galactose binding, soluble 3	Mus musculus	24-34
21330041-9	2011	CONCLUSIONS: Vasopressin enhances adrenal gland perfusion, but decreases noradrenaline plasma concentration when compared to adrenaline during CPR.	Epinephrine	76-86	vasopressin	Sus scrofa	13-24
21349852-12	2011	However, in adipocytes in insulin-stimulated conditions, glucose clearance was significantly faster following adrenaline addition in comparison with controls (p < 0.001).	Epinephrine	110-120	insulin	Homo sapiens	26-33
21237150-2	2011	administered (+-)-epibatidine (a non-selective agonist of nicotinic acetylcholine receptors) elevates plasma noradrenaline and adrenaline through brain nicotinic acetylcholine receptor-mediated mechanisms in rats.	Epinephrine	112-122	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	58-90
20460337-9	2011	Although the lack of response to epinephrine and aspirin treatment displayed similarities in aggregations using epinephrine, ADP, collagen, and thrombin, they differed in aggregations using AA and for ATP secretion.	Epinephrine	33-44	coagulation factor II, thrombin	Homo sapiens	144-152
20860878-4	2011	The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine.	Epinephrine	67-78	catechol-O-methyltransferase	Homo sapiens	11-40
20860878-4	2011	The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine.	Epinephrine	67-78	catechol-O-methyltransferase	Homo sapiens	42-46
21136013-2	2011	In this work, we show that inhibition of ADP-mediated phosphorylation of pleckstrin, the main PKC substrate, caused by antagonists of the P2Y12 receptor can be reversed by stimulation of the alpha2-adrenergic receptor by epinephrine.	Epinephrine	221-232	purinergic receptor P2Y12	Homo sapiens	138-143
21262951-5	2011	RESULTS: In contrast to patients with VHL, SDHB, and SDHD mutations, all patients with MEN 2 and NF1 presented with tumors characterized by increased plasma concentrations of metanephrine (indicating epinephrine production).	Epinephrine	200-211	neurofibromin 1	Homo sapiens	97-100
21136013-8	2011	Addition of epinephrine to platelets was also able to stimulate Rap1b activation.	Epinephrine	12-23	RAP1B, member of RAS oncogene family	Homo sapiens	64-69
21307766-0	2011	Pulmonary vasoconstrictive and bronchoconstrictive responses to anaphylaxis are weakened via beta2-adrenoceptor activation by endogenous epinephrine in anesthetized rats.	Epinephrine	137-148	adrenoceptor beta 2	Rattus norvegicus	93-111
21307766-11	2011	CONCLUSIONS: The pulmonary vasoconstrictive and bronchoconstrictive responses to systemic anaphylaxis were weakened via beta2-adrenoceptor activation by epinephrine endogenously released from the adrenal gland in the anesthetized Sprague-Dawley rats.	Epinephrine	153-164	adrenoceptor beta 2	Rattus norvegicus	120-138
21401511-7	2011	Moreover, the influence of the peripheral nervous system involving several neurotransmitters (acetylcholine, noradrenaline, adrenaline, dopamine, serotonin) on liver function may also be important for the physiological regulation of hepatic CYP activity.	Epinephrine	112-122	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	241-244
21365590-8	2011	CONCLUSION: Since dopamine and other monoamines (epinephrine and serotonine) play a role in ADHD, and methylphenidate, an usual treatment for this type of patients, modifies the VMAT2 activity, we may argue that VMAT2 is involved in ADHD pathogeny.	Epinephrine	49-60	solute carrier family 18 member A2	Homo sapiens	178-183
21148475-7	2011	Leptin infusion reduced (P < 0.05) food intake and body weight, and it also increased plasma epinephrine concentration at 6 h and 7 days, suggesting increased sympathetic nerve activity.	Epinephrine	96-107	leptin	Ovis aries	0-6
21148475-11	2011	In conclusion, although central leptin infusion in sheep caused the predicted reduction in food intake and increases plasma epinephrine concentration, it had no effect on AMPK activation in skeletal muscle and actually reduced glucose disposal.	Epinephrine	124-135	leptin	Ovis aries	32-38
21345315-0	2011	PKC inhibitors RO 31-8220 and Go 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation.	Epinephrine	46-57	AKT serine/threonine kinase 1	Homo sapiens	143-146
21345315-7	2011	The present data also suggest that impaired Akt phosphorylation may be responsible for epinephrine hypo-responsiveness of platelets.	Epinephrine	87-98	AKT serine/threonine kinase 1	Homo sapiens	44-47
21127260-6	2011	Epinephrine treatment decreased phosphorylation of the mitogen-activated protein kinases (MAPK) ERK1/2 and p38; these decreases were also reversed with timolol.	Epinephrine	0-11	mitogen-activated protein kinase 3	Homo sapiens	90-94
21147885-9	2011	Patients with multiple endocrine neoplasia type 2 and neurofibromatosis type 1, all with epinephrine-producing tumors, were similarly diagnosed with disease at a later age than patients with tumors that lacked appreciable epinephrine production secondary to mutations of von Hippel-Lindau and succinate dehydrogenase genes (40 +- 2 vs. 31 +- 1 yr, P < 0.001).	Epinephrine	89-100	neurofibromin 1	Homo sapiens	54-78
21127260-6	2011	Epinephrine treatment decreased phosphorylation of the mitogen-activated protein kinases (MAPK) ERK1/2 and p38; these decreases were also reversed with timolol.	Epinephrine	0-11	mitogen-activated protein kinase 3	Homo sapiens	96-102
21127260-6	2011	Epinephrine treatment decreased phosphorylation of the mitogen-activated protein kinases (MAPK) ERK1/2 and p38; these decreases were also reversed with timolol.	Epinephrine	0-11	mitogen-activated protein kinase 1	Homo sapiens	107-110
20682615-7	2011	Epinephrine increased monocyte attachment to laminin in lean and obese IR subjects through involvement of NHE-1, PKC, NO synthase, NADPH oxidase and actin polymerization.	Epinephrine	0-11	solute carrier family 9 member A1	Homo sapiens	106-111
21166930-5	2011	In contrast, activation by epinephrine both increased cAMP levels and TER and resulted in linearized VE-cadherin distribution, however this was not sufficient to block barrier-destabilization by propranolol.	Epinephrine	27-38	cadherin 5	Rattus norvegicus	101-112
20927436-10	2011	Two inducers of glucose uptake were shown to be non-cytotoxic and confirmed as insulin mimetic compounds by their inhibition of epinephrine-stimulated free fatty acid release from adipocytes.	Epinephrine	128-139	insulin	Homo sapiens	79-86
20102772-10	2011	The percentage changes in epinephrine concentration from baseline to the end of exercise were correlated with the percentage changes in total adiponectin concentration (r = -0.67, P &lt; .05) and MLMW adiponectin concentration (r = -0.82, P &lt; .05) from baseline to the end of HE.	Epinephrine	26-37	adiponectin, C1Q and collagen domain containing	Homo sapiens	142-153
20102772-10	2011	The percentage changes in epinephrine concentration from baseline to the end of exercise were correlated with the percentage changes in total adiponectin concentration (r = -0.67, P &lt; .05) and MLMW adiponectin concentration (r = -0.82, P &lt; .05) from baseline to the end of HE.	Epinephrine	26-37	adiponectin, C1Q and collagen domain containing	Homo sapiens	201-212
20102772-12	2011	Epinephrine may partially regulate the decrease in total and MLMW adiponectin concentrations during high-intensity exercise.	Epinephrine	0-11	adiponectin, C1Q and collagen domain containing	Homo sapiens	66-77
20153492-0	2011	Effects of adrenaline on whole-body glucose metabolism and insulin-mediated regulation of glycogen synthase and PKB phosphorylation in human skeletal muscle.	Epinephrine	11-21	protein tyrosine kinase 2 beta	Homo sapiens	112-115
20153492-1	2011	In the present study, we investigated the effect of adrenaline on insulin-mediated regulation of glucose and fat metabolism with focus on regulation of skeletal muscle PKB, GSK-3, and glycogen synthase (GS) phosphorylation.	Epinephrine	52-62	insulin	Homo sapiens	66-73
20153492-8	2011	In the presence of adrenaline, insulin did neither activate GS nor dephosphorylate GS Ser641.	Epinephrine	19-29	insulin	Homo sapiens	31-38
20153492-11	2011	In conclusion, adrenaline did not influence basal or insulin-stimulated PKB and GSK-3beta phosphorylation in muscles, but completely blocked insulin-mediated GS activation and Ser641 dephosphorylation.	Epinephrine	15-25	insulin	Homo sapiens	141-148
20153492-12	2011	Still, insulin normalized adrenaline-mediated hyperglycemia.	Epinephrine	26-36	insulin	Homo sapiens	7-14
21448321-8	2011	Epinephrine demand (median: 0.08 mug/kg*min; range: 0.02-0.63 mug/kg*min) was negatively correlated with male adiponectin levels (r = -0.58; P &lt; 0.01; females: r = -0.36; P = 0.19) and positively correlated with resistin levels (r = 0.43; P = 0.02).	Epinephrine	0-11	adiponectin, C1Q and collagen domain containing	Homo sapiens	110-121
21448321-11	2011	Adiponectin levels were negatively correlated with epinephrine demand in male patients and epinephrine demand was positively correlated with resistin levels, which might have increased insulin resistance.	Epinephrine	51-62	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
21448321-11	2011	Adiponectin levels were negatively correlated with epinephrine demand in male patients and epinephrine demand was positively correlated with resistin levels, which might have increased insulin resistance.	Epinephrine	91-102	insulin	Homo sapiens	185-192
20237834-3	2011	Constitutive phosphorylation of ERK, mRNA expression up-regulation of catecholamine-synthesis enzymes, and increased epinephrine release were detected in MCF-7/Her2 cells.	Epinephrine	117-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	154-164
20237834-4	2011	beta2-AR expression induced by epinephrine and involvement of ERK signaling were validated.	Epinephrine	31-42	adrenoceptor beta 2	Homo sapiens	0-8
20875861-9	2011	Overall, our data suggest that AP-2beta plays critical roles in the epinephrine phenotype and maturation of adrenal chromaffin cells.	Epinephrine	68-79	transcription factor AP-2 beta	Mus musculus	31-39
21253359-1	2011	The pancreatic beta cell harbors alpha2-adrenergic and glucagon-like peptide-1 (GLP-1) receptors on its plasma membrane to sense the corresponding ligands adrenaline/noradrenaline and GLP-1 to govern glucose-stimulated insulin secretion.	Epinephrine	155-165	glucagon	Rattus norvegicus	80-85
19760428-8	2011	Correlations between serum levels of CgA and catecholamines (adrenaline, noradrenaline and dopamine) were evident for hyperthermia (R = 0.632-0.757, p &lt; 0.05 to &lt;0.01), but there was no significant correlation between CgA and catecholamine levels in CSF.	Epinephrine	61-71	chromogranin A	Homo sapiens	37-40
21524255-4	2011	In the sympathoadrenomedullary system, PACAP is required for sustained epinephrine secretion during metabolic stress.	Epinephrine	71-82	adenylate cyclase activating polypeptide 1	Homo sapiens	39-44
20937667-9	2010	CONCLUSIONS: Sympathetic, cardiac, and endothelial functions are preserved in patients with GCH1 mutations despite a neurological phenotype, reduced plasma biopterin, and norepinepherine and epinephrine concentrations.	Epinephrine	191-202	GTP cyclohydrolase 1	Homo sapiens	92-96
22007271-1	2011	The stress hormone, epinephrine, is produced predominantly by adrenal chromaffin cells and its biosynthesis is regulated by the enzyme phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	20-31	phenylethanolamine-N-methyltransferase	Rattus norvegicus	135-173
22007271-1	2011	The stress hormone, epinephrine, is produced predominantly by adrenal chromaffin cells and its biosynthesis is regulated by the enzyme phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	20-31	phenylethanolamine-N-methyltransferase	Rattus norvegicus	175-179
21401303-7	2011	Furthermore, secretion of adiponectin from adipocytes incubated with glucose and insulin was reduced by 1 and 2 microM epinephrine, but not by 0.25 and 0.5 microM epinephrine.	Epinephrine	119-130	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	26-37
21401303-12	2011	The obtained results indicated that in short-term regulation of adiponectin secretion, insulin and epinephrine exert the opposite effects.	Epinephrine	99-110	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	64-75
21388249-5	2011	Thrombin-induced alpha-granule secretion, measured by the release of fibrinogen in gel-filtered platelets, was also potentiated by adrenaline at thrombin concentrations above 0.05 U/ml.	Epinephrine	131-141	coagulation factor II, thrombin	Homo sapiens	0-8
21388249-5	2011	Thrombin-induced alpha-granule secretion, measured by the release of fibrinogen in gel-filtered platelets, was also potentiated by adrenaline at thrombin concentrations above 0.05 U/ml.	Epinephrine	131-141	fibrinogen beta chain	Homo sapiens	69-79
21388249-5	2011	Thrombin-induced alpha-granule secretion, measured by the release of fibrinogen in gel-filtered platelets, was also potentiated by adrenaline at thrombin concentrations above 0.05 U/ml.	Epinephrine	131-141	coagulation factor II, thrombin	Homo sapiens	145-153
21388249-6	2011	In contrast, adrenaline had little effect on thrombin-induced secretion of beta-acetyl-hexosaminidase and potentiated very little liberation of arachidonate at high thrombin concentrations.	Epinephrine	13-23	coagulation factor II, thrombin	Homo sapiens	165-173
21388249-7	2011	When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor.	Epinephrine	252-262	fibrinogen beta chain	Homo sapiens	170-180
21388249-7	2011	When autocrine stimulation was inhibited by the removal of secreted ADP by creatine phosphate/creatine phosphate kinase and specific blocking of the thromboxane A(2) and fibrinogen receptors, the potentiation of thrombin-induced ADP + ATP secretion by adrenaline was reduced and this reduction was mostly due to the blocking of the thromboxane A(2) receptor.	Epinephrine	252-262	coagulation factor II, thrombin	Homo sapiens	212-220
21388249-8	2011	Protein tyrosine phosphorylation by both thrombin and collagen was reduced by adrenaline, and inhibitors of autocrine stimulation counteracted this reduction.	Epinephrine	78-88	coagulation factor II, thrombin	Homo sapiens	41-49
21058678-1	2010	In this Article, we present a novel method to detect adrenaline on poly(3-aminobenzylamine) (PABA) ultrathin films by electrochemical-surface plasmon resonance (EC-SPR) spectroscopy.	Epinephrine	53-63	sepiapterin reductase	Homo sapiens	164-167
21058678-3	2010	The specific reaction of benzylamine within the PABA structure with adrenaline was studied by XPS, UV-vis spectroscopy, and EC-SPR techniques.	Epinephrine	68-78	sepiapterin reductase	Homo sapiens	127-130
21058678-4	2010	Adrenaline was detected in real time by EC-SPR spectroscopy, which provides simultaneous monitoring of both optical SPR reflectivity and electrochemical current responses upon injecting adrenaline into the PABA thin film.	Epinephrine	0-10	sepiapterin reductase	Homo sapiens	43-46
21058678-4	2010	Adrenaline was detected in real time by EC-SPR spectroscopy, which provides simultaneous monitoring of both optical SPR reflectivity and electrochemical current responses upon injecting adrenaline into the PABA thin film.	Epinephrine	0-10	sepiapterin reductase	Homo sapiens	116-119
21058678-4	2010	Adrenaline was detected in real time by EC-SPR spectroscopy, which provides simultaneous monitoring of both optical SPR reflectivity and electrochemical current responses upon injecting adrenaline into the PABA thin film.	Epinephrine	186-196	sepiapterin reductase	Homo sapiens	43-46
21058678-4	2010	Adrenaline was detected in real time by EC-SPR spectroscopy, which provides simultaneous monitoring of both optical SPR reflectivity and electrochemical current responses upon injecting adrenaline into the PABA thin film.	Epinephrine	186-196	sepiapterin reductase	Homo sapiens	116-119
21058678-5	2010	The number of changes in both current and SPR reflectivity on the injection of adrenaline exhibited the linear relation to the concentration, and the detection limit was 100 pM.	Epinephrine	79-89	sepiapterin reductase	Homo sapiens	42-45
28352374-3	2010	This is a case report of a patient with atrial fibrillation (AF) and transient ischemic attack (TIA) induced by vigrous snake bite that was suspected to be caused by the treatment of subcutaneous epinephrine, due to immediate hypersensitivity reaction following the administration of antivenom treatment.	Epinephrine	196-207	centrosomal protein 70	Homo sapiens	126-130
20858707-4	2010	hPMAT is highly selective toward serotonin (5-HT) and dopamine, with the rank order of transport efficiency (V(max)/K(m)) being: dopamine, 5-HT &gt;&gt; histamine, norepinephrine, epinephrine.	Epinephrine	167-178	solute carrier family 29 member 4	Homo sapiens	0-5
20954794-1	2010	The alpha(1)-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate several physiological effects of epinephrine and norepinephrine.	Epinephrine	126-137	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	48-56
20858707-6	2010	In contrast, hOCT3 is less selective than hPMAT toward the monoamines, and the V(max)/K(m) rank order for hOCT3 is: histamine &gt; norepinephrine, epinephrine &gt; dopamine &gt;5-HT.	Epinephrine	134-145	solute carrier family 22 member 3	Homo sapiens	13-18
20954794-1	2010	The alpha(1)-adrenergic receptor (AR) subtypes (alpha(1a), alpha(1b), and alpha(1d)) mediate several physiological effects of epinephrine and norepinephrine.	Epinephrine	126-137	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	59-67
20858707-6	2010	In contrast, hOCT3 is less selective than hPMAT toward the monoamines, and the V(max)/K(m) rank order for hOCT3 is: histamine &gt; norepinephrine, epinephrine &gt; dopamine &gt;5-HT.	Epinephrine	134-145	solute carrier family 22 member 3	Homo sapiens	106-111
20858707-9	2010	Our results suggest that hOCT3 represents a major uptake(2) transporter for histamine, epinephrine, and norepinephrine.	Epinephrine	87-98	solute carrier family 22 member 3	Homo sapiens	25-30
21154325-1	2010	The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Epinephrine	178-189	catechol-O-methyltransferase	Homo sapiens	11-39
21154325-1	2010	The enzyme catechol-O-methyltransferase (COMT) transfers a methyl group from S-adenosylmethionine to the benzene ring of catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Epinephrine	178-189	catechol-O-methyltransferase	Homo sapiens	41-45
20739620-0	2010	Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue.	Epinephrine	0-11	pyruvate dehydrogenase kinase 4	Rattus norvegicus	35-39
21079815-7	2010	We found a significant decrease in the abundance of LAT RNA by 2 h post-iontophoresis of epinephrine coupled to an increase in the transcript abundance of ICP4 in the McKrae strain of HSV-1.	Epinephrine	89-100	LAT	Human alphaherpesvirus 1	52-55
20837485-5	2010	Furthermore, norepinephrine-induced changes in the beta(2)AR FRET sensor were slower than those induced by epinephrine (rate constants, 47 versus 128 ms).	Epinephrine	16-27	adrenoceptor beta 2	Homo sapiens	51-60
20739620-11	2010	The p38 inhibitor SB202190 reduced epinephrine-mediated increases in p38 MAPK activation without altering hormone-sensitive lipase or AMPK phosphorylation or attenuating epinephrine-induced increases in lipolysis.	Epinephrine	35-46	mitogen activated protein kinase 14	Rattus norvegicus	4-7
20739620-11	2010	The p38 inhibitor SB202190 reduced epinephrine-mediated increases in p38 MAPK activation without altering hormone-sensitive lipase or AMPK phosphorylation or attenuating epinephrine-induced increases in lipolysis.	Epinephrine	35-46	mitogen activated protein kinase 14	Rattus norvegicus	69-72
20739620-7	2010	Exercise, fasting, and in or ex vivo epinephrine treatment increased PDK4 mRNA levels.	Epinephrine	37-48	pyruvate dehydrogenase kinase 4	Rattus norvegicus	69-73
20739620-14	2010	Our results are the very first to demonstrate an epinephrine-mediated regulation of PDK4 mRNA levels in white adipose tissue and suggest that p38 MAPK and PPARgamma could be involved in this pathway.	Epinephrine	49-60	pyruvate dehydrogenase kinase 4	Rattus norvegicus	84-88
20739620-14	2010	Our results are the very first to demonstrate an epinephrine-mediated regulation of PDK4 mRNA levels in white adipose tissue and suggest that p38 MAPK and PPARgamma could be involved in this pathway.	Epinephrine	49-60	mitogen activated protein kinase 14	Rattus norvegicus	142-145
20739620-10	2010	In cultured adipose tissue, epinephrine increased p38 and AMPK signaling; however, the direct activation of AMPK by AICAR or metformin led to reductions in PDK4 mRNA levels.	Epinephrine	28-39	mitogen activated protein kinase 14	Rattus norvegicus	50-53
20739620-14	2010	Our results are the very first to demonstrate an epinephrine-mediated regulation of PDK4 mRNA levels in white adipose tissue and suggest that p38 MAPK and PPARgamma could be involved in this pathway.	Epinephrine	49-60	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	155-164
20618356-3	2010	infusion of adrenaline (0.1 nmol kg-1 min-1) or placebo.	Epinephrine	12-22	CD59 molecule (CD59 blood group)	Homo sapiens	38-43
20680617-1	2010	In this study, the first micro-total analysis system (mu-TAS) for catecholamines (dopamine, epinephrine, and norepinephrine) analysis in which preconcentration, separation, and determination steps were integrated on a microchip was developed.	Epinephrine	92-103	THAS	Homo sapiens	57-60
21046458-4	2010	Under basal conditions, VMAT1 is widely expressed in all adrenal chromaffin cells, while VMAT2 is co-localized with tyrosine hydroxylase (TH) but not phenylethanolamine N-methyltransferase (PNMT), indicating its expression in norepinephrine (NE)-, but not epinephrine (Epi)-synthesizing chromaffin cells.	Epinephrine	229-240	solute carrier family 18 member A2	Rattus norvegicus	89-94
20937870-2	2010	During the fight-or-flight response, epinephrine released by the adrenal medulla and norepinephrine released from sympathetic nerves increase muscle contractility by activation of the beta-adrenergic receptor/cAMP-dependent protein kinase pathway and up-regulation of Ca(V)1 channels in skeletal and cardiac muscle.	Epinephrine	37-48	caveolin-1	Oryctolagus cuniculus	268-274
21046459-3	2010	Epinephrine itself is regulated by stress through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28).	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Rattus norvegicus	70-108
21046459-3	2010	Epinephrine itself is regulated by stress through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28).	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Rattus norvegicus	110-114
20602110-8	2010	The R-848-induced TNF-alpha production in RAW264 cells was significantly inhibited by epinephrine and norepinephrine pre-treatment, although IFN-alpha was not detected.	Epinephrine	86-97	tumor necrosis factor	Mus musculus	18-27
20619316-6	2010	Our results show that epinephrine may have a role in brown fat mitochondrial uncoupling through regulation of Ucp-1 and Pgc-1alpha, although this is not required to maintain a normal temperature during acute cold exposure.	Epinephrine	22-33	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	110-115
20619316-6	2010	Our results show that epinephrine may have a role in brown fat mitochondrial uncoupling through regulation of Ucp-1 and Pgc-1alpha, although this is not required to maintain a normal temperature during acute cold exposure.	Epinephrine	22-33	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	120-130
20619316-7	2010	We conclude that epinephrine may have an important role in induction of Ucp-1 and Pgc-1alpha gene expression during cold stress.	Epinephrine	17-28	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	72-77
20619316-7	2010	We conclude that epinephrine may have an important role in induction of Ucp-1 and Pgc-1alpha gene expression during cold stress.	Epinephrine	17-28	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	82-92
20637325-0	2010	Epinephrine accelerates osteoblastic differentiation by enhancing bone morphogenetic protein signaling through a cAMP/protein kinase A signaling pathway.	Epinephrine	0-11	bone morphogenetic protein 1	Homo sapiens	66-92
20606161-4	2010	Stored FVIII was mobilized into the circulation by subcutaneous administration of epinephrine.	Epinephrine	82-93	coagulation factor VIII	Mus musculus	7-12
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Epinephrine	94-104	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Epinephrine	94-104	phenylethanolamine N-methyltransferase	Homo sapiens	6-44
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Epinephrine	127-137	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
20642456-2	2010	PNMT (phenylethanolamine N-methyltransferase) catalyses the final step in the biosynthesis of adrenaline, the conversion of noradrenaline (norepinephrine) to adrenaline by methylation.	Epinephrine	127-137	phenylethanolamine N-methyltransferase	Homo sapiens	6-44
20637325-2	2010	Epinephrine enhanced bone induction by BMP-2.	Epinephrine	0-11	bone morphogenetic protein 2	Homo sapiens	39-44
20637325-3	2010	Thus, the mass of ossicles ectopically induced by BMP-2 (5 mug) was increased by the addition of a low dose (10, 20, 40, or 80 mug) of epinephrine into a biodegradable BMP-2 carrier, in a dose-dependent manner.	Epinephrine	135-146	bone morphogenetic protein 2	Homo sapiens	50-55
20621581-7	2010	Epinephrine pre-treatment enhanced surface expression of MHCII, CD80 and CD86.	Epinephrine	0-11	histocompatibility-2, MHC	Mus musculus	57-62
20637325-3	2010	Thus, the mass of ossicles ectopically induced by BMP-2 (5 mug) was increased by the addition of a low dose (10, 20, 40, or 80 mug) of epinephrine into a biodegradable BMP-2 carrier, in a dose-dependent manner.	Epinephrine	135-146	bone morphogenetic protein 2	Homo sapiens	168-173
20637325-4	2010	To investigate the mechanism by which epinephrine enhances BMP activity, in vitro experiments were carried out using osteogenic cells.	Epinephrine	38-49	bone morphogenetic protein 1	Homo sapiens	59-62
20637325-5	2010	The expression level of alkaline phosphatase (ALP) in cells, a marker of osteoblastic differentiation, was consistently elevated by BMP-2 (50 ng/ml) and was further elevated by the addition of epinephrine (10(-8)M).	Epinephrine	193-204	alkaline phosphatase, placental	Homo sapiens	24-44
20637325-5	2010	The expression level of alkaline phosphatase (ALP) in cells, a marker of osteoblastic differentiation, was consistently elevated by BMP-2 (50 ng/ml) and was further elevated by the addition of epinephrine (10(-8)M).	Epinephrine	193-204	alkaline phosphatase, placental	Homo sapiens	46-49
20637325-6	2010	The epinephrine-enhanced ALP elevation was specifically abolished by an antagonist to beta2-adrenergic receptors (Butoxamine) and by a protein kinase A inhibitor (H89).	Epinephrine	4-15	alkaline phosphatase, placental	Homo sapiens	25-28
20637325-7	2010	Furthermore, BMP-induced mRNA expression of ALP and osteocalcin (marker proteins of osteoblastic differentiation) and of Osterix (a transcription factor essential for terminal differentiation to osteoblasts) in ST2 cells was significantly enhanced by the addition of epinephrine (10(-8)M).	Epinephrine	267-278	bone morphogenetic protein 1	Homo sapiens	13-16
20621581-7	2010	Epinephrine pre-treatment enhanced surface expression of MHCII, CD80 and CD86.	Epinephrine	0-11	CD80 antigen	Mus musculus	64-68
20637325-7	2010	Furthermore, BMP-induced mRNA expression of ALP and osteocalcin (marker proteins of osteoblastic differentiation) and of Osterix (a transcription factor essential for terminal differentiation to osteoblasts) in ST2 cells was significantly enhanced by the addition of epinephrine (10(-8)M).	Epinephrine	267-278	bone gamma-carboxyglutamate protein	Homo sapiens	52-63
20637325-7	2010	Furthermore, BMP-induced mRNA expression of ALP and osteocalcin (marker proteins of osteoblastic differentiation) and of Osterix (a transcription factor essential for terminal differentiation to osteoblasts) in ST2 cells was significantly enhanced by the addition of epinephrine (10(-8)M).	Epinephrine	267-278	Sp7 transcription factor	Homo sapiens	121-128
20621581-7	2010	Epinephrine pre-treatment enhanced surface expression of MHCII, CD80 and CD86.	Epinephrine	0-11	CD86 antigen	Mus musculus	73-77
20637325-8	2010	In luciferase expression assays using the promoter sequence of the Id1 gene (an immediate early response gene to BMP), luciferase activity was elevated by BMP-2 treatment (50 ng/ml) and this activity was further enhanced by the addition of epinephrine (10(-8)M).	Epinephrine	240-251	inhibitor of DNA binding 1, HLH protein	Homo sapiens	67-70
20621581-8	2010	Quantitative RT-PCR showed that epinephrine pre-treatment induced a significant transcriptional decrease of IL-12p40 and a significant increase of IL-12p35 and IL-23p19.	Epinephrine	32-43	interleukin 12b	Mus musculus	108-116
20637325-8	2010	In luciferase expression assays using the promoter sequence of the Id1 gene (an immediate early response gene to BMP), luciferase activity was elevated by BMP-2 treatment (50 ng/ml) and this activity was further enhanced by the addition of epinephrine (10(-8)M).	Epinephrine	240-251	bone morphogenetic protein 1	Homo sapiens	113-116
20637325-8	2010	In luciferase expression assays using the promoter sequence of the Id1 gene (an immediate early response gene to BMP), luciferase activity was elevated by BMP-2 treatment (50 ng/ml) and this activity was further enhanced by the addition of epinephrine (10(-8)M).	Epinephrine	240-251	bone morphogenetic protein 2	Homo sapiens	155-160
20621581-8	2010	Quantitative RT-PCR showed that epinephrine pre-treatment induced a significant transcriptional decrease of IL-12p40 and a significant increase of IL-12p35 and IL-23p19.	Epinephrine	32-43	interleukin 12a	Mus musculus	147-155
20637325-9	2010	Epinephrine-enhanced luciferase activity was abolished by mutation of the cAMP-response element (CRE) sequence in the Id1 promoter, indicating that CRE-binding transcription proteins induced by epinephrine addition may act as enhancers of Smad-mediated BMP signaling.	Epinephrine	0-11	inhibitor of DNA binding 1, HLH protein	Homo sapiens	118-121
20637325-9	2010	Epinephrine-enhanced luciferase activity was abolished by mutation of the cAMP-response element (CRE) sequence in the Id1 promoter, indicating that CRE-binding transcription proteins induced by epinephrine addition may act as enhancers of Smad-mediated BMP signaling.	Epinephrine	0-11	bone morphogenetic protein 1	Homo sapiens	253-256
20621581-8	2010	Quantitative RT-PCR showed that epinephrine pre-treatment induced a significant transcriptional decrease of IL-12p40 and a significant increase of IL-12p35 and IL-23p19.	Epinephrine	32-43	interleukin 23, alpha subunit p19	Mus musculus	160-168
20621581-10	2010	Epinephrine pre-treatment also induced a significant decrease of IL-12p70 and a significant increase of IL-23 and IL-10 cytokine production.	Epinephrine	0-11	interleukin 23, alpha subunit p19	Mus musculus	104-109
20637325-9	2010	Epinephrine-enhanced luciferase activity was abolished by mutation of the cAMP-response element (CRE) sequence in the Id1 promoter, indicating that CRE-binding transcription proteins induced by epinephrine addition may act as enhancers of Smad-mediated BMP signaling.	Epinephrine	194-205	inhibitor of DNA binding 1, HLH protein	Homo sapiens	118-121
20637325-9	2010	Epinephrine-enhanced luciferase activity was abolished by mutation of the cAMP-response element (CRE) sequence in the Id1 promoter, indicating that CRE-binding transcription proteins induced by epinephrine addition may act as enhancers of Smad-mediated BMP signaling.	Epinephrine	194-205	bone morphogenetic protein 1	Homo sapiens	253-256
20621581-10	2010	Epinephrine pre-treatment also induced a significant decrease of IL-12p70 and a significant increase of IL-23 and IL-10 cytokine production.	Epinephrine	0-11	interleukin 10	Mus musculus	114-119
20738760-2	2010	In the present study, we demonstrate that both primary and secondary wave aggregation induced by adrenaline in plasma is blocked by two structurally distinct inhibitors of Src family kinases, dasatinib and PD0173952.	Epinephrine	97-107	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	172-175
20738760-4	2010	The ability of adrenaline to inhibit adenylyl cyclase and to synergize with platelet agonists in mediating platelet activation in plasma is retained in the presence of Src family kinase inhibition.	Epinephrine	15-25	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	168-171
20467749-6	2010	TPO did not change myocardial contractility in basal conditions, but, when followed by epinephrine (EPI) stimulation, it blunted the enhancement of contractile force induced by EPI both in papillary muscle and isolated heart.	Epinephrine	87-98	thrombopoietin	Homo sapiens	0-3
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Epinephrine	39-50	cAMP responsive element binding protein 1	Mus musculus	149-186
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Epinephrine	39-50	cAMP responsive element binding protein 1	Mus musculus	188-192
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Epinephrine	39-50	CREB regulated transcription coactivator 2	Mus musculus	223-265
20852621-2	2010	Elevations in circulating glucagon and epinephrine, two hormones that activate hepatic gluconeogenesis, trigger the cAMP-mediated phosphorylation of cAMP response element-binding protein (Creb) and dephosphorylation of the Creb-regulated transcription coactivator-2 (Crtc2)--two key transcriptional regulators of this process.	Epinephrine	39-50	CREB regulated transcription coactivator 2	Mus musculus	267-272
20664901-7	2010	Under such conditions, TRA-418 inhibited both U-46619 + epinephrine-induced and TRAP-induced platelet-leukocyte complex formation in a concentration-dependent manner, in a similar range.	Epinephrine	56-67	T cell receptor alpha locus	Homo sapiens	23-26
21160910-11	2010	Adrenaline activated NHE-1 (p = &lt;0.0001 to 0.01) by a process involving the classical isoforms of PKC, NOS and actin polymerization.	Epinephrine	0-10	solute carrier family 9 member A1	Homo sapiens	21-26
21160910-11	2010	Adrenaline activated NHE-1 (p = &lt;0.0001 to 0.01) by a process involving the classical isoforms of PKC, NOS and actin polymerization.	Epinephrine	0-10	proline rich transmembrane protein 2	Homo sapiens	101-104
20707367-1	2010	In the present study, a novel assay for screening inhibitors of Cu(II) ion/adrenaline-mediated oxidative modification of N-terminal amyloid beta (Abeta) peptides was developed using liquid chromatography with mass spectrometry (LC/MS).	Epinephrine	75-85	amyloid beta precursor protein	Homo sapiens	146-151
20707367-2	2010	The physiological condition of Cu(II) ion/adrenaline in buffer (pH 7.4) at 37 degrees C for 90 min revealed a specific modification of N-terminal Abeta peptides, such as Abeta1-6, Abeta1-40, and Abeta1-42, using trypsin digestion and LC/MS detection of the modified Abeta peptide.	Epinephrine	42-52	amyloid beta precursor protein	Homo sapiens	146-151
20707367-2	2010	The physiological condition of Cu(II) ion/adrenaline in buffer (pH 7.4) at 37 degrees C for 90 min revealed a specific modification of N-terminal Abeta peptides, such as Abeta1-6, Abeta1-40, and Abeta1-42, using trypsin digestion and LC/MS detection of the modified Abeta peptide.	Epinephrine	42-52	amyloid beta precursor protein	Homo sapiens	170-175
20707367-7	2010	This novel assay may allow for the identification of antioxidants that protect against oxidative modification of Abeta and other proteins related to oxidative stress by adrenaline and Cu(II) ions under normal physiologic conditions.	Epinephrine	169-179	amyloid beta precursor protein	Homo sapiens	113-118
20510373-1	2010	The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli.	Epinephrine	182-193	catechol-O-methyltransferase	Homo sapiens	65-93
20510373-1	2010	The functional Val158Met polymorphism in the gene coding for the catechol-O-methyltransferase (COMT), the major enzyme degrading the catecholaminergic neurotransmitters dopamine, norepinephrine, and epinephrine, has been associated with differential reactivity in limbic and prefrontal brain areas in response to aversive stimuli.	Epinephrine	182-193	catechol-O-methyltransferase	Homo sapiens	95-99
20654592-1	2010	Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells.	Epinephrine	48-59	phenylethanolamine-N-methyltransferase	Rattus norvegicus	88-126
20654592-1	2010	Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells.	Epinephrine	48-59	phenylethanolamine-N-methyltransferase	Rattus norvegicus	128-132
20654592-1	2010	Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells.	Epinephrine	48-59	phenylethanolamine-N-methyltransferase	Rattus norvegicus	138-142
20654592-1	2010	Hypoxia is shown to regulate the stress hormone epinephrine through its biosynthesis by phenylethanolamine N-methyltransferase (PNMT) via PNMT gene activation and transcription factors Egr-1 and Sp1 in adrenal medulla-derived PC12 cells.	Epinephrine	48-59	early growth response 1	Rattus norvegicus	185-190
20654592-11	2010	The effects of hypoxia on PNMT and thereby epinephrine may have important ramifications for the stress hormone epinephrine, its ability to regulate behavioral and physiological processes associated with stress and stress-elicited illness.	Epinephrine	111-122	phenylethanolamine-N-methyltransferase	Rattus norvegicus	26-30
20713709-5	2010	Addition of norepinephrine or epinephrine to the culture medium stimulated ghrelin secretion, and this effect was blocked by atenolol, a selective beta(1)-adrenergic antagonist.	Epinephrine	15-26	ghrelin	Mus musculus	75-82
20478367-7	2010	Further, expression of the epinephrine synthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), was observed suggesting a possible role for this transmitter in the bud.	Epinephrine	27-38	phenylethanolamine-N-methyltransferase	Rattus norvegicus	57-95
20519139-2	2010	administered corticotropin-releasing factor (CRF) (0.5-3.0 nmol/animal) dose-dependently elevates plasma noradrenaline and adrenaline through brain phospholipase C-, diacylglycerol lipase- and prostanoids-mediated mechanisms in rats.	Epinephrine	108-118	corticotropin releasing hormone	Rattus norvegicus	13-43
20503062-2	2010	To assess the functional role of adrenergic signaling in the auditory periphery, we studied mice with targeted deletion of the gene for dopamine beta-hydroxylase (DBH), which catalyzes the conversion of dopamine to noradrenaline; thus, these mutant mice have no measurable adrenaline or noradrenaline.	Epinephrine	218-228	dopamine beta hydroxylase	Mus musculus	136-161
20503062-2	2010	To assess the functional role of adrenergic signaling in the auditory periphery, we studied mice with targeted deletion of the gene for dopamine beta-hydroxylase (DBH), which catalyzes the conversion of dopamine to noradrenaline; thus, these mutant mice have no measurable adrenaline or noradrenaline.	Epinephrine	218-228	dopamine beta hydroxylase	Mus musculus	163-166
20679729-9	2010	Strikingly, plasma epinephrine concentration as well as urinary excretion of catecholamine metabolites were substantially elevated in Trpm4-/- mice.	Epinephrine	19-30	transient receptor potential cation channel, subfamily M, member 4	Mus musculus	134-139
20478367-7	2010	Further, expression of the epinephrine synthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), was observed suggesting a possible role for this transmitter in the bud.	Epinephrine	27-38	phenylethanolamine-N-methyltransferase	Rattus norvegicus	97-101
20406625-13	2010	Both PDE3 and PDE4 blunt left atrial inotropic and cAMP responses to (-)-adrenaline through beta(2)-adrenoceptors.	Epinephrine	69-83	phosphodiesterase 4A	Homo sapiens	14-18
20351730-5	2010	IL-6 release from adipocytes was measured in vitro, under nonstimulated conditions and also with two concentrations of epinephrine in the medium.	Epinephrine	119-130	interleukin 6	Rattus norvegicus	0-4
20351730-8	2010	However, a significant interaction was found between the epinephrine dose and the diet in IL-6 release regulation.	Epinephrine	57-68	interleukin 6	Rattus norvegicus	90-94
20351730-9	2010	CONCLUSIONS: IL-6 release from adipocytes was markedly regulated by the dietary fatty acid composition, even under epinephrine stimulation, with lower values of IL-6 release in the olive oil diet.	Epinephrine	115-126	interleukin 6	Rattus norvegicus	13-17
20811227-1	2010	BACKGROUND: The authors have observed that carpal tunnel surgery nerve blocks consisting of subfascial distal volar forearm injection of 10 cc of 1% lidocaine with epinephrine result in fingers that appear hyperemic, warm, and numb in both median and ulnar nerve distributions.	Epinephrine	164-175	NUMB endocytic adaptor protein	Homo sapiens	227-231
20434498-4	2010	In various densities, networks of orexin-positive fibers and terminals were present on neurons of each adrenaline (C1, C2, C3) and noradrenaline (locus coeruleus, A1, A2, A4, A5 and A7) cell groups.	Epinephrine	103-113	hypocretin neuropeptide precursor	Homo sapiens	34-40
22371762-1	2010	Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E).	Epinephrine	227-238	catechol-O-methyltransferase	Homo sapiens	112-140
22371762-1	2010	Catecholamine signaling pathways in the peripheral and central nervous systems (PNS, CNS, respectively) utilize catechol-O-methyltransferase (COMT) as a major regulatory enzyme responsible for deactivation of dopamine (DA), norepinephrine (NE) and epinephrine (E).	Epinephrine	227-238	catechol-O-methyltransferase	Homo sapiens	142-146
20351045-0	2010	Adrenaline-induced colonic K+ secretion is mediated by KCa1.1 (BK) channels.	Epinephrine	0-10	potassium voltage-gated channel, shaker-related subfamily, member 1	Mus musculus	55-61
20360004-6	2010	Forskolin or epinephrine induced localized Rac activation dependent on Tiam1 and spinophilin.	Epinephrine	13-24	AKT serine/threonine kinase 1	Homo sapiens	43-46
20360004-6	2010	Forskolin or epinephrine induced localized Rac activation dependent on Tiam1 and spinophilin.	Epinephrine	13-24	TIAM Rac1 associated GEF 1	Homo sapiens	71-76
20360004-8	2010	In IRSp53-deficient cells, Tiam1 co-localized with spinophilin in response to forskolin or epinephrine.	Epinephrine	91-102	BAR/IMD domain containing adaptor protein 2	Homo sapiens	3-9
20360004-8	2010	In IRSp53-deficient cells, Tiam1 co-localized with spinophilin in response to forskolin or epinephrine.	Epinephrine	91-102	TIAM Rac1 associated GEF 1	Homo sapiens	27-32
20351306-6	2010	Microvascular endothelial cells from lung, heart, intestine, and skin as well as endothelial cells from pulmonary artery constitutively secreted FVIII and released it after treatment with phorbol-myristate acetate and epinephrine.	Epinephrine	218-229	coagulation factor VIII	Homo sapiens	145-150
20519125-9	2010	Adrenaline stimulates L-type Ca(2+) channel-dependent exocytosis by activation of the low-affinity cAMP sensor Epac2 via a large increase in [cAMP](i).	Epinephrine	0-10	Rap guanine nucleotide exchange factor 4	Homo sapiens	111-116
19940810-0	2010	Pre-exposure to vasopressin potentiates the vasoconstrictive effect of epinephrine in rat aorta isolated during late anaphylaxis.	Epinephrine	71-82	arginine vasopressin	Rattus norvegicus	16-27
19940810-7	2010	Aortic rings removed during late versus early anaphylaxis were less responsive to epinephrine (EC50 at 5 min, 8.4 nM [4.9 - 11.8]; EC50 at 30 min, 18.2 nM [11.9 - 24.4]; P = 0.04) and AVP (EC50 at 5 min, 8.1 nM [4.9 - 11.3]; EC50 at 30 min, 19.7 nM [10.9 - 28.6]; P = 0.02).	Epinephrine	82-93	arginine vasopressin	Rattus norvegicus	184-187
19940810-8	2010	Pre-exposure to AVP enhanced the subsequent contractile effect of epinephrine in aortic rings removed during late anaphylaxis (maximal contractile effect, 1.02 g [0.76 - 1.28]) versus early anaphylaxis (maximal contractile effect, 0.44 g [0.28 - 0.59]; P = 0.005).	Epinephrine	66-77	arginine vasopressin	Rattus norvegicus	16-19
20351116-7	2010	At 4 weeks post-MI, plasma levels of both norepinephrine and epinephrine were reduced in PNMT-driven GRK2 KO, compared with control mice, suggesting markedly reduced post-MI sympathetic activation.	Epinephrine	45-56	phenylethanolamine-N-methyltransferase	Mus musculus	89-93
20351116-7	2010	At 4 weeks post-MI, plasma levels of both norepinephrine and epinephrine were reduced in PNMT-driven GRK2 KO, compared with control mice, suggesting markedly reduced post-MI sympathetic activation.	Epinephrine	45-56	G protein-coupled receptor kinase 2	Mus musculus	101-105
19155075-8	2010	Concentrations of uric acid, epinephrine, and norepinephrine also correlated with ANP and BNP.	Epinephrine	29-40	natriuretic peptide A	Homo sapiens	82-85
19155075-8	2010	Concentrations of uric acid, epinephrine, and norepinephrine also correlated with ANP and BNP.	Epinephrine	29-40	natriuretic peptide B	Homo sapiens	90-93
20351045-9	2010	We found that adrenaline-induced K(+) secretion: (1) is absent in colonic epithelia from BK(/) mice, (2) is greatly up-regulated in mice on a high K(+) diet and (3) is present as sustained positive current in colonic epithelia from CFTR(/) mice.	Epinephrine	14-24	cystic fibrosis transmembrane conductance regulator	Mus musculus	232-236
20197504-10	2010	Higher platelet aggregation was found in MS. Adiponectin inversely correlated with P-selectin (R = -0.35, P = 0.009), sCD40L (r = -0.24, P = 0.05) and epinephrine and collagen induced aggregation (r = -0.80, P = 0.005; r = -0.70, P = 0.011).	Epinephrine	151-162	adiponectin, C1Q and collagen domain containing	Homo sapiens	45-56
20197504-12	2010	Platelet aggregatory response to epinephrine and ADP significantly decreased following preincubation with adiponectin (96 +/- 4 vs. 23 +/- 3%, P &lt; 0.001, and 102 +/- 9 vs. 85 +/- 9%, P = 0.004).	Epinephrine	33-44	adiponectin, C1Q and collagen domain containing	Homo sapiens	106-117
20139771-10	2010	The human CHGA tertiles also differed in epinephrine secretion as well as degree of CHGA processing to catestatin (catecholamine release-inhibitory peptide derived from CHGA processing).	Epinephrine	41-52	chromogranin A	Homo sapiens	10-14
20061295-15	2010	A significant positive correlation was determined between preoperative MMP-9 concentrations and 24-hour urinary fractionated metanephrine and epinephrine (r = 0.938, P = .006; r = 0.965, P = .002, respectively), between MMP-9 levels and baseline cortisol levels (r = 0.402, P = .003), and between MMP-9 levels and cortisol levels obtained after dexamethasone suppression testing (r = 0.357, P = .006).	Epinephrine	142-153	matrix metallopeptidase 9	Homo sapiens	71-76
20389021-3	2010	In an orthotopic mouse model of human ovarian cancer, restraint stress and the associated increases in norepinephrine and epinephrine protected the tumor cells from anoikis and promoted their growth by activating focal adhesion kinase (FAK).	Epinephrine	106-117	protein tyrosine kinase 2	Homo sapiens	213-234
20389021-3	2010	In an orthotopic mouse model of human ovarian cancer, restraint stress and the associated increases in norepinephrine and epinephrine protected the tumor cells from anoikis and promoted their growth by activating focal adhesion kinase (FAK).	Epinephrine	106-117	protein tyrosine kinase 2	Homo sapiens	236-239
20389021-6	2010	These data suggest that FAK modulation by stress hormones, especially norepinephrine and epinephrine, can contribute to tumor progression in patients with ovarian cancer and may point to potential new therapeutic targets for cancer management.	Epinephrine	73-84	protein tyrosine kinase 2	Homo sapiens	24-27
20179577-5	2010	The effect of ephedrine on epinephrine-mediated increases in platelet selectin (CD62p) activation was assessed with flow cytometry.	Epinephrine	27-38	selectin P	Homo sapiens	80-85
19944145-15	2010	High epinephrine concentrations increased murine skin fibroblast proliferation and nitric oxide synthesis, and strongly inhibited skin fibroblast migration and both pro- and active MMP-2.	Epinephrine	5-16	matrix metallopeptidase 2	Mus musculus	181-186
20004448-7	2010	After cardiac surgery with cardiopulmonary bypass, epinephrine inhibited the CD62l downregulation, the suppression of CD11b upregulation, and the generation of oxidative free radicals after FMLP stimulation.	Epinephrine	51-62	selectin P	Homo sapiens	77-81
20004448-7	2010	After cardiac surgery with cardiopulmonary bypass, epinephrine inhibited the CD62l downregulation, the suppression of CD11b upregulation, and the generation of oxidative free radicals after FMLP stimulation.	Epinephrine	51-62	integrin subunit alpha M	Homo sapiens	118-123
20004448-7	2010	After cardiac surgery with cardiopulmonary bypass, epinephrine inhibited the CD62l downregulation, the suppression of CD11b upregulation, and the generation of oxidative free radicals after FMLP stimulation.	Epinephrine	51-62	formyl peptide receptor 1	Homo sapiens	190-194
20004448-8	2010	The pre-operative administration of beta-blockers abolished the immunomodulatory effects of epinephrine on CD62l and CD11b expression and the generation of oxidative free radicals.	Epinephrine	92-103	selectin L	Homo sapiens	107-112
20004448-8	2010	The pre-operative administration of beta-blockers abolished the immunomodulatory effects of epinephrine on CD62l and CD11b expression and the generation of oxidative free radicals.	Epinephrine	92-103	integrin subunit alpha M	Homo sapiens	117-122
20204374-2	2010	Although the epinephrine biosynthetic enzyme PNMT genetic locus displays both linkage and association to such traits, genetic variation underlying these quantitative phenotypes is not established.	Epinephrine	13-24	phenylethanolamine N-methyltransferase	Homo sapiens	45-49
21180298-17	2010	Thus non-selective (e.g. propranolol) or modestly beta-1 selective (e.g. metoprolol, atenolol) are associated with metabolic disturbance, bronchospasm, epinephrine/hypertensive interaction (with cigarette-smoking or insulin-induced hypoglycaemia), while the possession of alpha-blocking activity (e.g. carvedilol) is associated with dizziness and postural hypotension.	Epinephrine	152-163	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	50-56
19804812-0	2010	Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle.	Epinephrine	81-92	cathelicidin antimicrobial peptide	Rattus norvegicus	15-19
20182366-5	2010	The patient underwent repeated excision and grafting during which an epinephrine solution that contained bovine thrombin was used to facilitate hemostasis.	Epinephrine	69-80	coagulation factor II, thrombin	Bos taurus	112-120
19804812-0	2010	Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle.	Epinephrine	81-92	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	20-24
19804812-2	2010	The present work tested the hypothesis that epinephrine-induced inhibition of muscle proteolysis is mediated through the cAMP/Epac/PI3K-dependent pathway with the involvement of AKT and Foxo.	Epinephrine	44-55	cathelicidin antimicrobial peptide	Rattus norvegicus	121-125
19804812-2	2010	The present work tested the hypothesis that epinephrine-induced inhibition of muscle proteolysis is mediated through the cAMP/Epac/PI3K-dependent pathway with the involvement of AKT and Foxo.	Epinephrine	44-55	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	126-130
19804812-2	2010	The present work tested the hypothesis that epinephrine-induced inhibition of muscle proteolysis is mediated through the cAMP/Epac/PI3K-dependent pathway with the involvement of AKT and Foxo.	Epinephrine	44-55	AKT serine/threonine kinase 1	Rattus norvegicus	178-181
19804812-3	2010	The incubation of extensor digitorum longus (EDL) muscles from rats with epinephrine and/or insulin increased the phosphorylation of AKT and its downstream target Foxo3a, a well-known effect that prevents Foxo translocation to the nucleus and the activation of proteolysis.	Epinephrine	73-84	AKT serine/threonine kinase 1	Rattus norvegicus	133-136
19804812-3	2010	The incubation of extensor digitorum longus (EDL) muscles from rats with epinephrine and/or insulin increased the phosphorylation of AKT and its downstream target Foxo3a, a well-known effect that prevents Foxo translocation to the nucleus and the activation of proteolysis.	Epinephrine	73-84	forkhead box O3	Rattus norvegicus	163-169
19804812-5	2010	The stimulatory effect of epinephrine on AKT phosphorylation was completely blocked by wortmannin (selective PI3K inhibitor), suggesting that the epinephrine-induced activation of AKT is mediated through PI3K.	Epinephrine	26-37	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
19804812-5	2010	The stimulatory effect of epinephrine on AKT phosphorylation was completely blocked by wortmannin (selective PI3K inhibitor), suggesting that the epinephrine-induced activation of AKT is mediated through PI3K.	Epinephrine	26-37	AKT serine/threonine kinase 1	Rattus norvegicus	180-183
19804812-5	2010	The stimulatory effect of epinephrine on AKT phosphorylation was completely blocked by wortmannin (selective PI3K inhibitor), suggesting that the epinephrine-induced activation of AKT is mediated through PI3K.	Epinephrine	146-157	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
19804812-5	2010	The stimulatory effect of epinephrine on AKT phosphorylation was completely blocked by wortmannin (selective PI3K inhibitor), suggesting that the epinephrine-induced activation of AKT is mediated through PI3K.	Epinephrine	146-157	AKT serine/threonine kinase 1	Rattus norvegicus	180-183
19804812-6	2010	As for epinephrine and DBcAMP, the incubation of muscles with 8CPT-2Me-cAMP (selective Epac agonist) reduced rates of proteolysis and increased phosphorylation levels of AKT and Foxo3a.	Epinephrine	7-18	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	87-91
19804812-7	2010	The specific PKA agonist (N6BZ-cAMP) inhibited proteolysis and abolished the epinephrine-induced AKT and Foxo3a phosphorylation.	Epinephrine	77-88	cathelicidin antimicrobial peptide	Rattus norvegicus	31-35
19804812-7	2010	The specific PKA agonist (N6BZ-cAMP) inhibited proteolysis and abolished the epinephrine-induced AKT and Foxo3a phosphorylation.	Epinephrine	77-88	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
19804812-7	2010	The specific PKA agonist (N6BZ-cAMP) inhibited proteolysis and abolished the epinephrine-induced AKT and Foxo3a phosphorylation.	Epinephrine	77-88	forkhead box O3	Rattus norvegicus	105-111
19804812-8	2010	On the other hand, inhibition of PKA by H89 further increased the phosphorylation levels of AKT and Foxo3a induced by epinephrine, DBcAMP or 8CPT-2Me-cAMP.	Epinephrine	118-129	AKT serine/threonine kinase 1	Rattus norvegicus	92-95
19804812-8	2010	On the other hand, inhibition of PKA by H89 further increased the phosphorylation levels of AKT and Foxo3a induced by epinephrine, DBcAMP or 8CPT-2Me-cAMP.	Epinephrine	118-129	forkhead box O3	Rattus norvegicus	100-106
19804812-9	2010	These findings suggest that the antiproteolytic effect of the epinephrine on isolated skeletal muscle may occur through a cAMP/Epac/PI3K-dependent pathway, which leads to the phosphorylation of AKT and Foxo3a.	Epinephrine	62-73	cathelicidin antimicrobial peptide	Rattus norvegicus	122-126
19804812-9	2010	These findings suggest that the antiproteolytic effect of the epinephrine on isolated skeletal muscle may occur through a cAMP/Epac/PI3K-dependent pathway, which leads to the phosphorylation of AKT and Foxo3a.	Epinephrine	62-73	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	127-131
19804812-9	2010	These findings suggest that the antiproteolytic effect of the epinephrine on isolated skeletal muscle may occur through a cAMP/Epac/PI3K-dependent pathway, which leads to the phosphorylation of AKT and Foxo3a.	Epinephrine	62-73	AKT serine/threonine kinase 1	Rattus norvegicus	194-197
19804812-9	2010	These findings suggest that the antiproteolytic effect of the epinephrine on isolated skeletal muscle may occur through a cAMP/Epac/PI3K-dependent pathway, which leads to the phosphorylation of AKT and Foxo3a.	Epinephrine	62-73	forkhead box O3	Rattus norvegicus	202-208
19854260-6	2010	Prior to the observed increase in NT-3 protein levels, the examined catecholamines increased NT-3 mRNA levels with maximal effects observed after 1h (noradrenaline) and 2h (adrenaline and dopamine) of incubation causing 2.4-, 2.6- and 3-fold elevation, respectively.	Epinephrine	153-163	neurotrophin 3	Rattus norvegicus	93-97
19854260-5	2010	Noradrenaline (1 microM), adrenaline (1 microM), and dopamine (100 microM) showed a maximal increase in NT-3 cellular content after 6h treatment causing a 1.9-, 1.8- and 2.7-fold elevation, respectively.	Epinephrine	3-13	neurotrophin 3	Rattus norvegicus	104-108
20090367-10	2010	Urine adrenaline was associated with increased hemodynamic shock and mortality, but was lowest in PNMT -161 A/A carriers.	Epinephrine	6-16	phenylethanolamine N-methyltransferase	Homo sapiens	98-102
19503019-2	2010	Adrenal glucocorticoid stimulates phenylethanolamine N-methyltransferase (PNMT) to convert norepinephrine to epinephrine in the adrenal medulla.	Epinephrine	94-105	phenylethanolamine-N-methyltransferase	Mus musculus	34-72
19503019-2	2010	Adrenal glucocorticoid stimulates phenylethanolamine N-methyltransferase (PNMT) to convert norepinephrine to epinephrine in the adrenal medulla.	Epinephrine	94-105	phenylethanolamine-N-methyltransferase	Mus musculus	74-78
19502771-4	2009	Norepinephrine and cortisol significantly increased (p&lt;0.01) at HA1 and HA2 compared to SL1, while epinephrine did not change.	Epinephrine	3-14	Rho GTPase activating protein 45	Homo sapiens	67-70
19738031-7	2009	Moreover, transgenic mice, which have approximately a 1.7-fold greater blood TGFBIp concentration, are significantly more susceptible to collagen- and epinephrine-induced pulmonary embolism than wild-type mice.	Epinephrine	151-162	transforming growth factor, beta induced	Mus musculus	77-83
19942396-12	2009	Advanced CPR: epinephrine dose known in 89.3 % (intravenous) and 34.3 % (tracheal).	Epinephrine	14-25	cytochrome p450 oxidoreductase	Homo sapiens	9-12
20065506-4	2009	RESULTS: We found that adrenaline increases COX-1 levels in the gastric tissue of both intact and adrenalectomized rats by stimulating alpha-2 receptors.	Epinephrine	23-33	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	44-49
20065506-5	2009	Adrenaline decreases COX-2 levels by stimulating beta-2 adrenergic receptors.	Epinephrine	0-10	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	21-26
19922897-11	2009	S-COMT activity was assessed as the amount of metanephrine formed by the action of S-COMT on an epinephrine substrate.	Epinephrine	96-107	catechol-O-methyltransferase	Homo sapiens	2-6
19396395-1	2009	Tyrosine hydroxylase (TH) catalyzes the conversion of L: -tyrosine to L: -dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [CA; dopamine (DA), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of CA.	Epinephrine	185-195	tyrosine hydroxylase	Homo sapiens	0-20
19396395-1	2009	Tyrosine hydroxylase (TH) catalyzes the conversion of L: -tyrosine to L: -dopa, which is the initial and rate-limiting step in the biosynthesis of catecholamines [CA; dopamine (DA), noradrenaline, and adrenaline], and plays a central role in the neurotransmission and hormonal actions of CA.	Epinephrine	185-195	tyrosine hydroxylase	Homo sapiens	22-24
19671882-10	2009	CHRNA3 SNPs and haplotypes containing K95K (G285A) associated with circulating plasma catestatin, epinephrine levels, as well as systolic BP, suggesting altered coupling of the nAChRs to BP.	Epinephrine	98-109	cholinergic receptor nicotinic alpha 3 subunit	Homo sapiens	0-6
19716369-0	2009	Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K-PDK1 signaling.	Epinephrine	0-11	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	85-89
19539715-2	2009	Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway, responsible for epinephrine biosynthesis, and is primarily localized in the adrenal gland.	Epinephrine	128-139	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
19539715-2	2009	Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in the catecholamine biosynthetic pathway, responsible for epinephrine biosynthesis, and is primarily localized in the adrenal gland.	Epinephrine	128-139	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
19539715-3	2009	In hypertensive rats, adrenal PNMT mRNA, protein and enzyme activity are elevated along with elevated levels of epinephrine, suggesting that increased expression of PNMT in the adrenal gland results in the increased adrenergic function associated with hypertension.	Epinephrine	112-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	165-169
19716369-2	2009	The present study explored whether epinephrine-induced hyperpolarization is modified by phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositide-dependent kinase PDK1.	Epinephrine	35-46	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	88-117
19716369-2	2009	The present study explored whether epinephrine-induced hyperpolarization is modified by phosphatidylinositol 3-kinase (PI3K) and phosphatidylinositide-dependent kinase PDK1.	Epinephrine	35-46	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	168-172
19716369-4	2009	At 16.8mM glucose, the cell membrane was hyperpolarized by epinephrine (1 microM), an effect significantly blunted in pdk1(fl/fl) and abrogated in wild-type cells by inhibition of PI3K with wortmannin (100 nM) or LY294002 (10 microM).	Epinephrine	59-70	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	118-122
19716369-5	2009	The hyperpolarizing effect of epinephrine in pancreatic islet cells is thus sensitive to PI3K and PDK1.	Epinephrine	30-41	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	98-102
19446054-0	2009	Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members.	Epinephrine	16-26	SRY (sex determining region Y)-box 9	Mus musculus	117-121
19446054-5	2009	Adrenaline also significantly inhibited gene transactivation by sry-type HMG box 9 (Sox9) family members essential for chondrogenic differentiation in a manner prevented by the general betaAdR antagonist propranolol, with a concomitant significant decrease in the levels of Sox6 mRNA and corresponding protein, in ATDC5 cells and primary cultured mouse costal chondrocytes.	Epinephrine	0-10	SRY (sex determining region Y)-box 9	Mus musculus	64-82
19446054-5	2009	Adrenaline also significantly inhibited gene transactivation by sry-type HMG box 9 (Sox9) family members essential for chondrogenic differentiation in a manner prevented by the general betaAdR antagonist propranolol, with a concomitant significant decrease in the levels of Sox6 mRNA and corresponding protein, in ATDC5 cells and primary cultured mouse costal chondrocytes.	Epinephrine	0-10	SRY (sex determining region Y)-box 9	Mus musculus	84-88
19446054-5	2009	Adrenaline also significantly inhibited gene transactivation by sry-type HMG box 9 (Sox9) family members essential for chondrogenic differentiation in a manner prevented by the general betaAdR antagonist propranolol, with a concomitant significant decrease in the levels of Sox6 mRNA and corresponding protein, in ATDC5 cells and primary cultured mouse costal chondrocytes.	Epinephrine	0-10	SRY (sex determining region Y)-box 6	Mus musculus	274-278
19446054-7	2009	These results suggest that adrenaline may interfere with chondrogenic differentiation through downregulation of Sox6 expression for subsequent suppression of gene transactivation mediated by Sox9 family members after activation of beta(2)AdR expressed by chondrocytes.	Epinephrine	27-37	SRY (sex determining region Y)-box 6	Mus musculus	112-116
19446054-7	2009	These results suggest that adrenaline may interfere with chondrogenic differentiation through downregulation of Sox6 expression for subsequent suppression of gene transactivation mediated by Sox9 family members after activation of beta(2)AdR expressed by chondrocytes.	Epinephrine	27-37	SRY (sex determining region Y)-box 9	Mus musculus	191-195
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Epinephrine	204-207	peptide YY	Cavia porcellus	12-15
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Epinephrine	204-207	pro-neuropeptide Y	Cavia porcellus	19-33
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Epinephrine	204-215	peptide YY	Cavia porcellus	12-15
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Epinephrine	204-215	pro-neuropeptide Y	Cavia porcellus	19-33
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Epinephrine	204-207	pro-neuropeptide Y	Cavia porcellus	35-38
19497958-2	2009	Addition of PYY or neuropeptide-Y (NPY) to the bathing solution of mucosae in Ussing chambers suppressed the short-circuit current (Isc) corresponding to electrogenic Cl- secretion, whether stimulated by epinephrine (epi), prostaglandin-E2 (PGE2), or carbachol (CCh).	Epinephrine	204-215	pro-neuropeptide Y	Cavia porcellus	35-38
19370475-0	2009	ErbB receptors protect the perfused heart against injury induced by epinephrine combined with low-flow ischemia.	Epinephrine	68-79	epidermal growth factor receptor	Mus musculus	0-4
19413597-0	2009	p38 mitogen-activated protein kinase (MAPK) is activated by noradrenaline and serves a cardioprotective role, whereas adrenaline induces p38 MAPK dephosphorylation.	Epinephrine	63-73	adapter molecule crk	Gallus gallus	0-3
19370475-3	2009	We examined here whether the ErbB sytem acutely protects the isolated heart in which stress was induced in vitro by ischemia combined with epinephrine infusion (EPI).	Epinephrine	139-150	epidermal growth factor receptor	Mus musculus	29-33
19429833-5	2009	Blockade of beta(1)- and beta(2)-adrenoceptors with 1 microM propranolol or beta(3)-adrenoceptor with 10 nM SR 59230A displaced rightward the concentration-NO production curve evoked by epinephrine.	Epinephrine	186-197	adrenoceptor beta 3	Rattus norvegicus	76-96
19672024-7	2009	AdpR1 mRNA expression was significantly associated with the tumor tissue adrenaline content (p&lt;0.005) in linear regression analysis, which suggest that adrenaline positively regulates AdpR1 mRNA expression.Serum total and HMW Adp levels in patients with NA-type pheochromocytomas were approximately 3 times higher than those of healthy volunteers.	Epinephrine	73-83	adiponectin receptor 1	Homo sapiens	0-5
19672024-7	2009	AdpR1 mRNA expression was significantly associated with the tumor tissue adrenaline content (p&lt;0.005) in linear regression analysis, which suggest that adrenaline positively regulates AdpR1 mRNA expression.Serum total and HMW Adp levels in patients with NA-type pheochromocytomas were approximately 3 times higher than those of healthy volunteers.	Epinephrine	73-83	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-3
19672024-7	2009	AdpR1 mRNA expression was significantly associated with the tumor tissue adrenaline content (p&lt;0.005) in linear regression analysis, which suggest that adrenaline positively regulates AdpR1 mRNA expression.Serum total and HMW Adp levels in patients with NA-type pheochromocytomas were approximately 3 times higher than those of healthy volunteers.	Epinephrine	155-165	adiponectin receptor 1	Homo sapiens	0-5
19672024-7	2009	AdpR1 mRNA expression was significantly associated with the tumor tissue adrenaline content (p&lt;0.005) in linear regression analysis, which suggest that adrenaline positively regulates AdpR1 mRNA expression.Serum total and HMW Adp levels in patients with NA-type pheochromocytomas were approximately 3 times higher than those of healthy volunteers.	Epinephrine	155-165	adiponectin receptor 1	Homo sapiens	187-192
19672024-7	2009	AdpR1 mRNA expression was significantly associated with the tumor tissue adrenaline content (p&lt;0.005) in linear regression analysis, which suggest that adrenaline positively regulates AdpR1 mRNA expression.Serum total and HMW Adp levels in patients with NA-type pheochromocytomas were approximately 3 times higher than those of healthy volunteers.	Epinephrine	155-165	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-3
19429833-9	2009	The NO production induced by epinephrine and BRL 37344 was associated with the activation of the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of eNOS in serine 1177.	Epinephrine	29-40	AKT serine/threonine kinase 1	Rattus norvegicus	127-130
19674349-6	2009	All patients with symptoms of IgE-mediated reactions to shellfish should receive epinephrine autoinjectors, even if the initial symptoms are mild.	Epinephrine	81-92	immunoglobulin heavy constant epsilon	Homo sapiens	30-33
19458062-9	2009	In conclusion, in the presence of basal plasma insulin and glucagon concentrations, a physiological increase in plasma epinephrine concentrations stimulates glucose production with an initial, 60-min transient phase caused by stimulation of NHG and a second phase that can mostly be attributed to a twofold increase in rates of gluconeogenesis.	Epinephrine	119-130	insulin	Homo sapiens	47-54
19559389-6	2009	Both epinephrine and ET-1, at antinociceptive concentrations, reduce blood flow in the skin; the effect from ET-1 is largely prevented by subcutaneous nimodipine.	Epinephrine	5-16	endothelin 1	Rattus norvegicus	109-113
19214174-7	2009	The AMPK inhibitor compound C (20 micromol/l) prevented AICAR-induced phosphorylation of AMPK and significantly increased basal (approximately 1.3-, 1.4-, and 1.7-fold) and epinephrine-stimulated (approximately 1.3-, 1.2-, 1.4-fold) glycerol release in epididymal, retroperitoneal, and inguinal adipocytes, respectively.	Epinephrine	173-184	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	4-8
19214174-8	2009	AICAR increased phosphorylation of HSL(Ser565) and inhibited epinephrine-induced phosphorylation of HSL(Ser563) and HSL(Ser660).	Epinephrine	61-72	lipase E, hormone sensitive type	Rattus norvegicus	100-103
19214174-8	2009	AICAR increased phosphorylation of HSL(Ser565) and inhibited epinephrine-induced phosphorylation of HSL(Ser563) and HSL(Ser660).	Epinephrine	61-72	lipase E, hormone sensitive type	Rattus norvegicus	100-103
19214174-9	2009	This was also accompanied by a 73% reduction in epinephrine-stimulated HSL activity.	Epinephrine	48-59	lipase E, hormone sensitive type	Rattus norvegicus	71-74
19109562-6	2009	Both in vivo thrombus formation in ferric chloride-injured arterioles and thrombocytopenia induced by collagen plus epinephrine challenge were more dramatic in Adamts13(S/S) than in Adamts13(L/L) but less than in Adamts13(-/-).	Epinephrine	116-127	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13	Mus musculus	160-168
19406554-11	2009	EPO-treated animals required a significantly smaller dose of epinephrine before resuscitation, compared to control rats.	Epinephrine	61-72	erythropoietin	Rattus norvegicus	0-3
19109562-6	2009	Both in vivo thrombus formation in ferric chloride-injured arterioles and thrombocytopenia induced by collagen plus epinephrine challenge were more dramatic in Adamts13(S/S) than in Adamts13(L/L) but less than in Adamts13(-/-).	Epinephrine	116-127	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13	Mus musculus	182-190
19293427-5	2009	Effector CD8(+) T cells were positively correlated with epinephrine rhythms, increased after low-dose epinephrine infusion, and showed highest expression of beta-adrenergic and fractalkine receptors (CX3CR1).	Epinephrine	56-67	CD8a molecule	Homo sapiens	9-12
19109562-6	2009	Both in vivo thrombus formation in ferric chloride-injured arterioles and thrombocytopenia induced by collagen plus epinephrine challenge were more dramatic in Adamts13(S/S) than in Adamts13(L/L) but less than in Adamts13(-/-).	Epinephrine	116-127	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13	Mus musculus	182-190
19172342-7	2009	Strong positive associations were found between BMI and levels of IL-6 (r=0.52) and epinephrine (r=0.54), and somewhat weaker associations with cortisol (r=0.32) and CRP (r=0.37).	Epinephrine	84-95	interleukin 6	Homo sapiens	66-70
19309436-4	2009	We observed that IL-1beta increases the release of NPY, norepinephrine (NE), and epinephrine (EP) from human chromaffin cells.	Epinephrine	59-70	interleukin 1 beta	Homo sapiens	17-25
19380024-6	2009	Increased ABCB1 mRNA expression and P-glycoprotein function levels in HT-29 cells by adrenaline was dose-dependent.	Epinephrine	85-95	ATP binding cassette subfamily B member 1	Homo sapiens	10-15
19380024-6	2009	Increased ABCB1 mRNA expression and P-glycoprotein function levels in HT-29 cells by adrenaline was dose-dependent.	Epinephrine	85-95	ATP binding cassette subfamily B member 1	Homo sapiens	36-50
19380024-11	2009	We conclude that adrenaline induces multidrug resistance in colon cancer cells by upregulating ABCB1 gene expression via alpha2-adrenergic receptors, and such effects were associated with the mitogen activated protein kinase (MAPK) pathway.	Epinephrine	17-27	ATP binding cassette subfamily B member 1	Homo sapiens	95-100
19380024-11	2009	We conclude that adrenaline induces multidrug resistance in colon cancer cells by upregulating ABCB1 gene expression via alpha2-adrenergic receptors, and such effects were associated with the mitogen activated protein kinase (MAPK) pathway.	Epinephrine	17-27	mitogen-activated protein kinase 3	Homo sapiens	226-230
19374330-1	2009	The role of prostaglandin H synthase-1 (PHS-1) and a related model enzyme, horseradish peroxidase (HRP), in catalyzing the bioactivation of dopamine (DA) and epinephrine and their precursors and metabolites to potential neurodegenerative free radical intermediates was examined.	Epinephrine	158-169	prostaglandin-endoperoxide synthase 1	Bos taurus	40-45
19380024-4	2009	The mRNA expression of the ABCB1 gene (previously MDR1) in human colon carcinoma HT-29 cell line was measured after treatment with an adrenergic receptor agonist (adrenaline) and various antagonists (propranolol, prazosin, and yohimbine).	Epinephrine	163-173	ATP binding cassette subfamily B member 1	Homo sapiens	27-32
19380024-4	2009	The mRNA expression of the ABCB1 gene (previously MDR1) in human colon carcinoma HT-29 cell line was measured after treatment with an adrenergic receptor agonist (adrenaline) and various antagonists (propranolol, prazosin, and yohimbine).	Epinephrine	163-173	ATP binding cassette subfamily B member 1	Homo sapiens	50-54
19374521-1	2009	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates biologically-active catechols, including the important neurotransmitters dopamine, noradrenaline and adrenaline.	Epinephrine	152-162	catechol-O-methyltransferase	Homo sapiens	0-28
19036879-3	2009	In the present study, we have analyzed the role of GC-dependent signaling in the postnatal development of adrenal chromaffin cells by conditional inactivation of the GR gene in cells expressing dopamine-beta-hydroxylase, an enzyme required for the synthesis of noradrenaline and adrenaline.	Epinephrine	264-274	dopamine beta hydroxylase	Mus musculus	194-219
19036879-5	2009	Our analysis shows that the loss of GR leads not only to the loss of phenylethanolamine-N-methyl-transferase expression and, therefore, to inhibition of adrenaline synthesis, but also to a dramatic reduction in the number of adrenal chromaffin cells.	Epinephrine	153-163	nuclear receptor subfamily 3, group C, member 1	Mus musculus	36-38
19220706-2	2009	Egr-1 and Sp1 contribute by stimulating the gene encoding the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), as shown for immobilization stress in rats in adrenal medulla and for hypoxic stress in adrenal medulla-derived PC12 cells.	Epinephrine	62-73	early growth response 1	Rattus norvegicus	0-5
19220706-2	2009	Egr-1 and Sp1 contribute by stimulating the gene encoding the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), as shown for immobilization stress in rats in adrenal medulla and for hypoxic stress in adrenal medulla-derived PC12 cells.	Epinephrine	62-73	phenylethanolamine-N-methyltransferase	Rattus norvegicus	95-133
19220706-2	2009	Egr-1 and Sp1 contribute by stimulating the gene encoding the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), as shown for immobilization stress in rats in adrenal medulla and for hypoxic stress in adrenal medulla-derived PC12 cells.	Epinephrine	62-73	phenylethanolamine-N-methyltransferase	Rattus norvegicus	135-139
19221126-2	2009	We hypothesized that (1) exercise training would increase PGC-1alpha mRNA expression in association with increases in mitochondrial marker enzymes, (2) adrenaline would increase PGC-1alpha mRNA expression and (3) the effect of exercise on PGC-1alpha mRNA expression in white adipose tissue would be attenuated by a beta-blocker.	Epinephrine	152-162	PPARG coactivator 1 alpha	Rattus norvegicus	178-188
19221126-2	2009	We hypothesized that (1) exercise training would increase PGC-1alpha mRNA expression in association with increases in mitochondrial marker enzymes, (2) adrenaline would increase PGC-1alpha mRNA expression and (3) the effect of exercise on PGC-1alpha mRNA expression in white adipose tissue would be attenuated by a beta-blocker.	Epinephrine	152-162	PPARG coactivator 1 alpha	Rattus norvegicus	178-188
19221126-5	2009	Adrenaline treatment of adipose tissue organ cultures led to dose-dependent increases in PGC-1alpha mRNA expression.	Epinephrine	0-10	PPARG coactivator 1 alpha	Rattus norvegicus	89-99
19221126-6	2009	A supra-physiological concentration of adrenaline increased PGC-1alpha mRNA expression in epididymal but not retroperitoneal adipose tissue.	Epinephrine	39-49	PPARG coactivator 1 alpha	Rattus norvegicus	60-70
19374521-1	2009	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates biologically-active catechols, including the important neurotransmitters dopamine, noradrenaline and adrenaline.	Epinephrine	152-162	catechol-O-methyltransferase	Homo sapiens	30-34
22444228-6	2009	The NA cows had a greater glucose response to epinephrine infusion across T1 and T2, and tended to have a greater insulin response to epinephrine infusion.	Epinephrine	134-145	insulin	Bos taurus	114-121
19222907-0	2009	Enhancement by adrenaline of ginsenoside Rg1 transport in Caco-2 cells and oral absorption in rats.	Epinephrine	15-25	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	41-44
19222907-1	2009	OBJECTIVES: The purpose of this research was to evaluate the ability of adrenaline (epinephrine) to stimulate the uptake of ginsenoside Rg1 (Rg1) by Caco-2 cells.	Epinephrine	72-82	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	136-139
19222907-1	2009	OBJECTIVES: The purpose of this research was to evaluate the ability of adrenaline (epinephrine) to stimulate the uptake of ginsenoside Rg1 (Rg1) by Caco-2 cells.	Epinephrine	72-82	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	141-144
19222907-1	2009	OBJECTIVES: The purpose of this research was to evaluate the ability of adrenaline (epinephrine) to stimulate the uptake of ginsenoside Rg1 (Rg1) by Caco-2 cells.	Epinephrine	84-95	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	136-139
19222907-1	2009	OBJECTIVES: The purpose of this research was to evaluate the ability of adrenaline (epinephrine) to stimulate the uptake of ginsenoside Rg1 (Rg1) by Caco-2 cells.	Epinephrine	84-95	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	141-144
19222907-3	2009	The Rg1 uptake medium with adrenaline at different concentrations was added to each well and incubated for different time intervals.	Epinephrine	27-37	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	4-7
19284971-9	2009	Conversely, the hypertensive response to epinephrine is attenuated in thrombospondin-1 null mice.	Epinephrine	41-52	thrombospondin 1	Mus musculus	70-86
19157885-3	2009	In this paper, we applied this methodology to investigate the affinity of epinephrine and isoproterenol towards two different systems: fibrinogen and platelets.	Epinephrine	74-85	fibrinogen beta chain	Homo sapiens	135-145
19374850-12	2009	These results suggest that centrally administered epibatidine activates the brain nicotinic acethylcholine receptors, thereby evoking the secretion of noradrenaline and adrenaline from the adrenal medulla by brain cyclooxygenase- and prostanoid TP receptor-mediated mechanisms in rats.	Epinephrine	154-164	thromboxane A2 receptor	Rattus norvegicus	214-256
19222907-7	2009	KEY FINDINGS: The incubation medium with adrenaline remarkably increased the amount of Rg1 uptake by Caco-2 cells.	Epinephrine	41-51	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	87-90
19222907-8	2009	Adrenaline-induced Rg1 transport increased in a dose- and time-dependent manner.	Epinephrine	0-10	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	19-22
19222907-9	2009	The effect of adrenergic antagonists on adrenaline-induced uptake of Rg1 was investigated and it was found that the enhancement effect was attenuated by the co-treatment with propranolol but not phentolamine.	Epinephrine	40-50	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	69-72
19222907-10	2009	The transport amount of Rg1 by Caco-2 cells increased in response to 1 mM adrenaline, isoproterenol or salbutamol.	Epinephrine	74-84	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	24-27
19222907-12	2009	The effect of adrenaline on the absorption of Rg1 was further investigated in vivo in rats.	Epinephrine	14-24	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	46-49
19222907-14	2009	The area under the plasma concentration-time curve of Rg1 after co-administration with 1 mM adrenaline was 79.1 +/- 31.04 microg/ml/h compared with 2.81 +/- 1.13 microg/ml/h for its aqueous solution.	Epinephrine	92-102	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	54-57
19222907-15	2009	CONCLUSIONS: Adrenaline is effective for the stimulation of intestinal absorption of Rg1 and the enhanced absorption is mediated mainly by the interaction of adrenaline with beta2-adrenoceptors.	Epinephrine	13-23	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	85-88
19222912-1	2009	OBJECTIVES: Our previous study suggested that adrenaline (epinephrine) could be an effective absorption enhancer for ginsenoside Rg1 (Rg1).	Epinephrine	46-56	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	129-132
19222912-1	2009	OBJECTIVES: Our previous study suggested that adrenaline (epinephrine) could be an effective absorption enhancer for ginsenoside Rg1 (Rg1).	Epinephrine	46-56	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	134-137
19222912-1	2009	OBJECTIVES: Our previous study suggested that adrenaline (epinephrine) could be an effective absorption enhancer for ginsenoside Rg1 (Rg1).	Epinephrine	58-69	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	129-132
19222912-1	2009	OBJECTIVES: Our previous study suggested that adrenaline (epinephrine) could be an effective absorption enhancer for ginsenoside Rg1 (Rg1).	Epinephrine	58-69	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	134-137
19222912-2	2009	This study focused on the transport mechanism of Rg1 and the role of sodium-dependent glucose co-transporter 1 in the regulation of Rg1 uptake after exposure to adrenaline.	Epinephrine	161-171	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	132-135
19222912-4	2009	Also the effect of D-glucose on adrenaline-induced absorption of Rg1 was investigated in vivo in rats.	Epinephrine	32-42	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	65-68
19222912-10	2009	Adrenaline-induced uptake of Rg1 was significantly inhibited in the presence of phlorizin and the absence of Na+.	Epinephrine	0-10	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	29-32
19222912-11	2009	In the in-vivo study in rats, it was found that after co-administration with D-glucose, the adrenaline-induced absorption of Rg1 was inhibited.	Epinephrine	92-102	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	125-128
19222912-13	2009	CONCLUSIONS: The data suggested that adrenaline enhanced the absorption of Rg1 by regulating sodium-dependent glucose co-transporter 1.	Epinephrine	37-47	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	75-78
19171483-1	2009	Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system.	Epinephrine	124-135	phenylethanolamine N-methyltransferase	Homo sapiens	14-52
19171483-1	2009	Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system.	Epinephrine	124-135	phenylethanolamine N-methyltransferase	Homo sapiens	54-58
18976638-3	2009	Emerging evidence indicates that brain noradrenergic systems contribute to the symptoms of mood disorders and may involve regulation of tyrosine hydroxylase (TH) expression, the rate-limiting enzyme in the biosynthesis of dopamine, norepinephrine and epinephrine.	Epinephrine	235-246	tyrosine hydroxylase	Rattus norvegicus	136-156
18814142-4	2009	Exposure to adrenaline not only increased cAMP formation, phosphorylation of cAMP responsive element (CRE) binding protein (CREB) on serine133 and CRE reporter activity in a manner sensitive to propranolol, but also rendered C3H10T1/2 cells resistant to the cytotoxicity of hydrogen peroxide, but not of either 2,4-dinitirophenol or tunicamycin.	Epinephrine	12-22	cAMP responsive element binding protein 1	Mus musculus	124-128
18814142-5	2009	Adrenaline induced a rapid but transient increase in mRNA expression of the antioxidative gene nuclear factor E2 p45-related factor-2 (Nrf2) along with an increase in the cystine/glutamate antiporter subunit xCT mRNA expression.	Epinephrine	0-10	nuclear factor, erythroid derived 2, like 2	Mus musculus	135-139
18814142-5	2009	Adrenaline induced a rapid but transient increase in mRNA expression of the antioxidative gene nuclear factor E2 p45-related factor-2 (Nrf2) along with an increase in the cystine/glutamate antiporter subunit xCT mRNA expression.	Epinephrine	0-10	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	208-211
18814142-7	2009	These results suggest that adrenaline may selectively protect mesenchymal C3H10T1/2 cells from oxidative stress through a mechanism related to the promoted biosynthesis of glutathione in association with transient Nrf2 expression after activation of beta(2)AdR.	Epinephrine	27-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	214-218
19167980-12	2009	RESULTS: In vitro studies demonstrated that epinephrine pretreatment significantly increased TNF-alpha production with LPS stimulation (P &lt; .05).	Epinephrine	44-55	tumor necrosis factor	Mus musculus	93-102
19167980-14	2009	MD-2, an essential coactivator of TLR-4 signaling, gene expression was significantly elevated when cells were pretreated with epinephrine before LPS exposure (P &lt; .001).	Epinephrine	126-137	toll-like receptor 4	Mus musculus	34-39
19143471-4	2009	Because keratinocytes express the beta2-adrenergic receptor (beta2AR), another study objective was to determine whether beta2AR antagonists could block epinephrine effects on healing and improve wound repair.	Epinephrine	152-163	adrenoceptor beta 2	Homo sapiens	120-127
19143471-13	2009	Burn wound injury in excised human skin also rapidly up-regulates the intra-epithelial expression of the epinephrine synthesizing enzyme phenylethanolamine-N-methyltransferase, and tissue levels of epinephrine rise dramatically (15-fold) in the burn wounded tissue (values of epinephrine expressed as pg/ug protein +/- standard error of the mean: unburned control, 0.6 +/- 0.36; immediately postburn, 9.6 +/- 1.58; 2 h postburn, 3.1 +/- 1.08; 24 h post-burn, 6.7 +/- 0.94).	Epinephrine	105-116	phenylethanolamine N-methyltransferase	Homo sapiens	137-175
19143471-15	2009	CONCLUSIONS: This work demonstrates an alternate pathway by which stress can impair healing: by stress-induced elevation of epinephrine levels resulting in activation of the keratinocyte beta2AR and the impairment of cell motility and wound re-epithelialization.	Epinephrine	124-135	adrenoceptor beta 2	Homo sapiens	187-194
18643838-6	2009	In the presence of epinephrine rosiglitazone stimulated free fatty acid release and increased diacylglycerol acyltransferase-1 (DGAT-1) mRNA suggest that ATGL and DGAT-1 may be cooperatively involved in rosiglitazone-stimulated triglyceride hydrolysis and fatty acid re-esterification in 3T3-L1 adipocytes.	Epinephrine	19-30	diacylglycerol O-acyltransferase 1	Mus musculus	94-126
18643838-6	2009	In the presence of epinephrine rosiglitazone stimulated free fatty acid release and increased diacylglycerol acyltransferase-1 (DGAT-1) mRNA suggest that ATGL and DGAT-1 may be cooperatively involved in rosiglitazone-stimulated triglyceride hydrolysis and fatty acid re-esterification in 3T3-L1 adipocytes.	Epinephrine	19-30	diacylglycerol O-acyltransferase 1	Mus musculus	128-134
18643838-6	2009	In the presence of epinephrine rosiglitazone stimulated free fatty acid release and increased diacylglycerol acyltransferase-1 (DGAT-1) mRNA suggest that ATGL and DGAT-1 may be cooperatively involved in rosiglitazone-stimulated triglyceride hydrolysis and fatty acid re-esterification in 3T3-L1 adipocytes.	Epinephrine	19-30	patatin-like phospholipase domain containing 2	Mus musculus	154-158
18643838-6	2009	In the presence of epinephrine rosiglitazone stimulated free fatty acid release and increased diacylglycerol acyltransferase-1 (DGAT-1) mRNA suggest that ATGL and DGAT-1 may be cooperatively involved in rosiglitazone-stimulated triglyceride hydrolysis and fatty acid re-esterification in 3T3-L1 adipocytes.	Epinephrine	19-30	diacylglycerol O-acyltransferase 1	Mus musculus	163-169
19025979-1	2009	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates bidirectional, sodium-independent transport of dopamine, norepinephrine, epinephrine, serotonin, and histamine.	Epinephrine	155-166	solute carrier family 22 member 3	Rattus norvegicus	0-28
19025979-1	2009	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates bidirectional, sodium-independent transport of dopamine, norepinephrine, epinephrine, serotonin, and histamine.	Epinephrine	155-166	solute carrier family 22 member 3	Rattus norvegicus	30-34
19139319-1	2009	BACKGROUND: Animal data on cardiac arrest showed improved long-term survival with combined vasopressin-epinephrine.	Epinephrine	103-114	arginine vasopressin	Homo sapiens	91-102
19964641-3	2009	LQT1 patients show increased variability of repolarization with epinephrine infusion, as measured from the 12-lead ECG.	Epinephrine	64-75	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	0-4
19233004-0	2009	Evaluation of centrifugation technique and effect of epinephrine on fat cell viability in autologous fat injection.	Epinephrine	53-64	FAT atypical cadherin 1	Homo sapiens	68-71
19233004-2	2009	Epinephrine may be harmful to fat cells.	Epinephrine	0-11	FAT atypical cadherin 1	Homo sapiens	30-33
19233004-3	2009	OBJECTIVE: We studied the effects of different centrifugation levels and epinephrine dosages on fat cell viability.	Epinephrine	73-84	FAT atypical cadherin 1	Homo sapiens	96-99
19233004-12	2009	The effect of epinephrine on fat cell viability is negligible.	Epinephrine	14-25	FAT atypical cadherin 1	Homo sapiens	29-32
19053318-0	2009	Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes.	Epinephrine	118-128	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	70-100
19120141-6	2008	In the adrenal, we detected increased levels of the epinephrine-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) after ether inhalation in vasopressin-deficient pups only.	Epinephrine	52-63	phenylethanolamine-N-methyltransferase	Rattus norvegicus	84-122
19212441-1	2009	Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6).	Epinephrine	157-168	tumor necrosis factor	Rattus norvegicus	286-294
19212441-1	2009	Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6).	Epinephrine	157-168	interleukin 1 beta	Rattus norvegicus	296-304
19212441-1	2009	Following our recent report that phagocytic cells (neutrophils, PMNs, and macrophages) are newly discovered sources of catecholamines, we now show that both epinephrine and norepinephrine directly activate NFkappaB in macrophages, causing enhanced release of proinflammatory cytokines (TNFalpha, IL-1beta, IL-6).	Epinephrine	157-168	interleukin 6	Rattus norvegicus	306-310
19212441-3	2009	Phagocytes isolated from adrenalectomized rats displayed enhanced expression of tyrosine-hydroxylase and dopamine-beta-hydroxylase, two key enzymes for catecholamine production and exhibited higher baseline secretion of norepinephrine and epinephrine.	Epinephrine	223-234	dopamine beta-hydroxylase	Rattus norvegicus	105-130
18952396-0	2009	Relationship between the milk yield response to short-term bovine somatotropin treatment and the lipolytic response to adrenaline in dairy cows.	Epinephrine	119-129	somatotropin	Bos taurus	66-78
18952396-1	2009	The aim of this experiment was to determine if the milk yield response of dairy cows to short-term treatment with bovine somatotropin (bST) was correlated with the non-esterified fatty-acid (NEFA) response to an adrenaline challenge.	Epinephrine	212-222	somatotropin	Bos taurus	121-133
19122447-1	2009	BACKGROUND AND AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter co-stored and co-released with noradrenaline and adrenaline.	Epinephrine	110-120	neuropeptide Y	Mus musculus	21-35
19122447-1	2009	BACKGROUND AND AIMS: Neuropeptide Y (NPY) is a sympathetic neurotransmitter co-stored and co-released with noradrenaline and adrenaline.	Epinephrine	110-120	neuropeptide Y	Mus musculus	37-40
19093734-10	2009	The partial antagonism of adenosine A(1) receptor increased lipolysis in cells incubated with epinephrine alone and epinephrine with insulin due to the synergistic action of 0.1 microM DPCPX and epinephrine.	Epinephrine	94-105	adenosine A1 receptor	Rattus norvegicus	26-49
19093734-10	2009	The partial antagonism of adenosine A(1) receptor increased lipolysis in cells incubated with epinephrine alone and epinephrine with insulin due to the synergistic action of 0.1 microM DPCPX and epinephrine.	Epinephrine	116-127	adenosine A1 receptor	Rattus norvegicus	26-49
19093734-10	2009	The partial antagonism of adenosine A(1) receptor increased lipolysis in cells incubated with epinephrine alone and epinephrine with insulin due to the synergistic action of 0.1 microM DPCPX and epinephrine.	Epinephrine	116-127	adenosine A1 receptor	Rattus norvegicus	26-49
19120124-2	2008	To identify when and where catecholamine-synthesizing cells are found in the embryonic heart, we developed a novel mouse genetic model by "knocking-in" the Cre-recombinase gene to the locus encoding for the epinephrine biosynthetic enzyme, phenylethanolamine n-methyltransferase.	Epinephrine	207-218	phenylethanolamine-N-methyltransferase	Mus musculus	240-278
19120125-1	2008	Phenylethanolamine N-methyltransferase (PNMT) catalyzes synthesis of epinephrine (E) and is present in the brain, heart, and adrenal.	Epinephrine	69-80	phenylethanolamine-N-methyltransferase	Mus musculus	0-38
19120125-1	2008	Phenylethanolamine N-methyltransferase (PNMT) catalyzes synthesis of epinephrine (E) and is present in the brain, heart, and adrenal.	Epinephrine	69-80	phenylethanolamine-N-methyltransferase	Mus musculus	40-44
19120127-3	2008	The coreleased epinephrine perhaps originates from in situ synthesis by phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	15-26	phenylethanolamine N-methyltransferase	Homo sapiens	72-110
19120127-3	2008	The coreleased epinephrine perhaps originates from in situ synthesis by phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	15-26	phenylethanolamine N-methyltransferase	Homo sapiens	112-116
19120141-6	2008	In the adrenal, we detected increased levels of the epinephrine-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) after ether inhalation in vasopressin-deficient pups only.	Epinephrine	52-63	phenylethanolamine-N-methyltransferase	Rattus norvegicus	124-128
18772317-1	2008	Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations.	Epinephrine	119-134	adrenoceptor beta 2	Homo sapiens	41-61
19070303-6	2008	The concentration of C-reactive protein was significantly higher (CTL: 0.028 +/- 0.005 mg x dl(-1); CMS: 0.025 +/-0.003 mg x dl(-1)), and that of adrenaline was significantly lower in CTL compared to CMS (CTL: 46.8 +/- 7.5 pg x ml(-1); CMS: 71 +/- 22.5 pg x ml(-1)).	Epinephrine	146-156	C-reactive protein	Homo sapiens	21-39
18756515-0	2008	Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats.	Epinephrine	131-141	Fc gamma receptor 1A	Rattus norvegicus	15-34
18756515-0	2008	Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats.	Epinephrine	131-141	toll-like receptor 4	Rattus norvegicus	39-59
18772317-1	2008	Fluorescence studies with purified human beta(2)-adrenoceptor (beta(2)AR) revealed that the endogenous catecholamines, (-)-epinephrine (EPI), (-)-norepinephrine (NE), and dopamine (DOP), stabilize distinct active receptor conformations.	Epinephrine	119-134	adrenoceptor beta 2	Homo sapiens	63-72
18775703-2	2008	By combining sequence alignment, the rhodopsin crystal structure, and point mutation data on the beta2 adrenoreceptor (b2ar), we predict a (-)-epinephrine-bound computational model of the beta2 adrenoreceptor.	Epinephrine	139-154	rhodopsin	Homo sapiens	37-46
18948049-3	2008	Lu/BCAM mediated cell adhesion to laminin is stimulated by epinephrine, a physiological stress mediator, and is dependent of phosphorylation by protein kinase A.	Epinephrine	59-70	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	3-7
18682266-4	2008	We found that (1) obese, aged mice lost the ability to transport intravenously administered ghrelin across the BBB, resulting in an inverse relation between body weight and ghrelin BBB permeability; (2) serum triglycerides promoted transport of intravenously administered ghrelin across the BBB, whereas epinephrine had no effect; (3) fasting tended to promote ghrelin transport across the BBB as most readily shown in brain perfusion studies; (4) evidence suggested that a serum factor promoted ghrelin transport in 8-week-old mice.	Epinephrine	304-315	ghrelin	Mus musculus	92-99
18981694-1	2008	Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT).	Epinephrine	37-48	catechol-O-methyltransferase	Rattus norvegicus	162-190
18981694-1	2008	Catecholamines, namely, dopamine, norepinephrine and epinephrine, play important roles in higher animals as neurotransmitters or hormones, and are metabolized by catechol-O-methyltransferase (COMT).	Epinephrine	37-48	catechol-O-methyltransferase	Rattus norvegicus	192-196
18821775-8	2008	We also report 600 ns molecular dynamics simulations that quantified beta 2-AR receptor mobility in a membrane bilayer environment and show how the binding of an agonist ligand, adrenaline (epinephrine), causes conformational changes to the ligand-binding pocket and neighboring helices.	Epinephrine	178-188	adrenoceptor beta 2	Homo sapiens	69-78
18821775-8	2008	We also report 600 ns molecular dynamics simulations that quantified beta 2-AR receptor mobility in a membrane bilayer environment and show how the binding of an agonist ligand, adrenaline (epinephrine), causes conformational changes to the ligand-binding pocket and neighboring helices.	Epinephrine	190-201	adrenoceptor beta 2	Homo sapiens	69-78
18775703-2	2008	By combining sequence alignment, the rhodopsin crystal structure, and point mutation data on the beta2 adrenoreceptor (b2ar), we predict a (-)-epinephrine-bound computational model of the beta2 adrenoreceptor.	Epinephrine	139-154	adrenoceptor beta 2	Homo sapiens	97-117
18775703-2	2008	By combining sequence alignment, the rhodopsin crystal structure, and point mutation data on the beta2 adrenoreceptor (b2ar), we predict a (-)-epinephrine-bound computational model of the beta2 adrenoreceptor.	Epinephrine	139-154	adrenoceptor beta 2	Homo sapiens	119-123
18775703-2	2008	By combining sequence alignment, the rhodopsin crystal structure, and point mutation data on the beta2 adrenoreceptor (b2ar), we predict a (-)-epinephrine-bound computational model of the beta2 adrenoreceptor.	Epinephrine	139-154	adrenoceptor beta 2	Homo sapiens	188-208
18361446-1	2008	Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin.	Epinephrine	93-104	monoamine oxidase A	Homo sapiens	0-19
18361446-1	2008	Monoamine oxidase A (MAOA) is an enzyme expressed in the brain that metabolizes dopamine, norepinephrine, epinephrine, and serotonin.	Epinephrine	93-104	monoamine oxidase A	Homo sapiens	21-25
18601899-2	2008	Epinephrine was found to promote within 60 min the translocation of AQP3 from the cytoplasmic fraction to the plasma membrane.	Epinephrine	0-11	aquaporin 3 (Gill blood group)	Homo sapiens	68-72
18799950-8	2008	Overall, the work to sleep change in epinephrine excretion was positively associated with changes in both SBP (P&lt;0.003) and DBP (P&lt;0.001); however, there was an ethnic difference in the epinephrine-BP relationship.	Epinephrine	37-48	selenium binding protein 1	Homo sapiens	106-109
18799950-8	2008	Overall, the work to sleep change in epinephrine excretion was positively associated with changes in both SBP (P&lt;0.003) and DBP (P&lt;0.001); however, there was an ethnic difference in the epinephrine-BP relationship.	Epinephrine	37-48	D-box binding PAR bZIP transcription factor	Homo sapiens	127-130
19001767-4	2008	The content of uncoupling protein 1 (UCP1) in IBAT and urinary noradrenaline and adrenaline excretions were significantly higher in rats fed the 0.1 or 0.2% oleuropein diet, as compared with those of rats fed with the control diet, although there were no significant differences in rats fed the 0.4% oleuropein diet.	Epinephrine	66-76	uncoupling protein 1	Rattus norvegicus	15-35
19001767-4	2008	The content of uncoupling protein 1 (UCP1) in IBAT and urinary noradrenaline and adrenaline excretions were significantly higher in rats fed the 0.1 or 0.2% oleuropein diet, as compared with those of rats fed with the control diet, although there were no significant differences in rats fed the 0.4% oleuropein diet.	Epinephrine	66-76	uncoupling protein 1	Rattus norvegicus	37-41
18542929-7	2008	A single injection of epinephrine to C-sectioned rats just after birth prevented the increased TH activity and DAT binding seen in C-sectioned rats after repeated mild stress at adulthood.	Epinephrine	22-33	solute carrier family 6 member 3	Rattus norvegicus	111-114
18628210-11	2008	The plasma epinephrine and norepinephrine levels in the beta3-Tg mice were significantly increased in the basal state, indicating enhanced sympathetic tone.	Epinephrine	11-22	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	56-61
18838811-0	2008	TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion.	Epinephrine	64-74	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
18838811-2	2008	TRPV1 activation by the intake of capsaicin, the irritant in hot pepper, induces adrenaline secretion and increases energy consumption.	Epinephrine	81-91	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
18647601-0	2008	Centrally administered neuromedin U elevates plasma adrenaline by brain prostanoid TP receptor-mediated mechanisms in rats.	Epinephrine	52-62	neuromedin U	Rattus norvegicus	23-35
18647601-11	2008	The neuromedin U-induced adrenaline response was also abolished by acute bilateral adrenalectomy.	Epinephrine	25-35	neuromedin U	Rattus norvegicus	4-16
18647601-12	2008	These results suggest that centrally administered neuromedin U evokes the secretion of adrenaline from the adrenal medulla by brain prostanoid TP receptor-mediated mechanisms in rats.	Epinephrine	87-97	neuromedin U	Rattus norvegicus	50-62
18601899-5	2008	Phosphorylation of a threonine (514) residue in PKC was detected upon the treatment with epinephrine and the temporal transitional pattern of this phosphorylation paralleled that of the increased trafficking of AQP3.	Epinephrine	89-100	aquaporin 3 (Gill blood group)	Homo sapiens	211-215
18621055-0	2008	Epinephrine-induced Ca2+ influx in vascular endothelial cells is mediated by CNGA2 channels.	Epinephrine	0-11	cyclic nucleotide gated channel alpha 2	Mus musculus	77-82
18594791-10	2008	Urinary epinephrine and norepinephrine excretion in Il1ra (-/-) mice was significantly increased compared with WT mice, suggesting that Il1ra (-/-) mice have increased sympathetic tone.	Epinephrine	8-19	interleukin 1 receptor antagonist	Mus musculus	52-57
18781914-4	2008	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Epinephrine	295-306	interferon gamma	Homo sapiens	30-46
18781914-4	2008	The pro-inflammatory cytokine interferon-gamma stimulates the biosynthesis of 5,6,7,8-tetrahydrobiopterin (BH4), which is cofactor for several aromatic amino acid monooxygenases and thus is strongly involved in the biosynthesis of the neurotransmitter serotonin and the catecholamines dopamine, epinephrine (adrenaline) and norepinephrine (noradrenaline).	Epinephrine	308-318	interferon gamma	Homo sapiens	30-46
18452159-0	2008	Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway.	Epinephrine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-182
18452159-6	2008	Epinephrine also increased extracellular signal-regulated kinase-1/2 (ERK1/2) phosphorylation as well as cyclooxygenase-2 (COX-2) and cytosolic phospholipase A(2) expression, which were blocked by beta(1)- or beta(2)-selective antagonists.	Epinephrine	0-11	mitogen-activated protein kinase 1	Homo sapiens	27-68
18452159-6	2008	Epinephrine also increased extracellular signal-regulated kinase-1/2 (ERK1/2) phosphorylation as well as cyclooxygenase-2 (COX-2) and cytosolic phospholipase A(2) expression, which were blocked by beta(1)- or beta(2)-selective antagonists.	Epinephrine	0-11	mitogen-activated protein kinase 3	Homo sapiens	70-76
18452159-6	2008	Epinephrine also increased extracellular signal-regulated kinase-1/2 (ERK1/2) phosphorylation as well as cyclooxygenase-2 (COX-2) and cytosolic phospholipase A(2) expression, which were blocked by beta(1)- or beta(2)-selective antagonists.	Epinephrine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	105-121
18452159-6	2008	Epinephrine also increased extracellular signal-regulated kinase-1/2 (ERK1/2) phosphorylation as well as cyclooxygenase-2 (COX-2) and cytosolic phospholipase A(2) expression, which were blocked by beta(1)- or beta(2)-selective antagonists.	Epinephrine	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	123-128
18452159-8	2008	Furthermore, epinephrine increased the expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-1 and -2 in a beta(2)-adrenoceptor-, mitogen-activated protein kinase/ERK kinase (MEK)-, and COX-2-dependent manner.	Epinephrine	13-24	vascular endothelial growth factor A	Homo sapiens	53-87
18452159-8	2008	Furthermore, epinephrine increased the expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-1 and -2 in a beta(2)-adrenoceptor-, mitogen-activated protein kinase/ERK kinase (MEK)-, and COX-2-dependent manner.	Epinephrine	13-24	vascular endothelial growth factor A	Homo sapiens	89-93
18452159-8	2008	Furthermore, epinephrine increased the expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-1 and -2 in a beta(2)-adrenoceptor-, mitogen-activated protein kinase/ERK kinase (MEK)-, and COX-2-dependent manner.	Epinephrine	13-24	fms related receptor tyrosine kinase 1	Homo sapiens	96-126
18452159-8	2008	Furthermore, epinephrine increased the expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-1 and -2 in a beta(2)-adrenoceptor-, mitogen-activated protein kinase/ERK kinase (MEK)-, and COX-2-dependent manner.	Epinephrine	13-24	mitogen-activated protein kinase 1	Homo sapiens	188-191
18452159-8	2008	Furthermore, epinephrine increased the expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-1 and -2 in a beta(2)-adrenoceptor-, mitogen-activated protein kinase/ERK kinase (MEK)-, and COX-2-dependent manner.	Epinephrine	13-24	mitogen-activated protein kinase kinase 7	Homo sapiens	200-203
18452159-8	2008	Furthermore, epinephrine increased the expression of vascular endothelial growth factor (VEGF), VEGF receptor (VEGFR)-1 and -2 in a beta(2)-adrenoceptor-, mitogen-activated protein kinase/ERK kinase (MEK)-, and COX-2-dependent manner.	Epinephrine	13-24	prostaglandin-endoperoxide synthase 2	Homo sapiens	211-216
18452159-9	2008	MEK or COX-2 inhibitor also significantly inhibited HKESC-1 cell proliferation induced by epinephrine.	Epinephrine	90-101	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
18452159-9	2008	MEK or COX-2 inhibitor also significantly inhibited HKESC-1 cell proliferation induced by epinephrine.	Epinephrine	90-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	7-12
18452159-10	2008	Collectively, we demonstrate that epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of ERK/COX-2 pathway.	Epinephrine	34-45	mitogen-activated protein kinase 1	Homo sapiens	162-165
18452159-10	2008	Collectively, we demonstrate that epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of ERK/COX-2 pathway.	Epinephrine	34-45	prostaglandin-endoperoxide synthase 2	Homo sapiens	166-171
18552163-5	2008	TNNI3K improved cardiac function by enhancing beating frequency and increasing the contractile force and epinephrine response of spontaneous action potentials without an increase of the single-cell size.	Epinephrine	105-116	TNNI3 interacting kinase	Mus musculus	0-6
17940877-5	2008	In hypoxic neonates we observed up-regulation (P &lt; 0.001) of the NMDAR1 gene expression whereas glucose and glucose + oxygen was able to significantly reverse (P &lt; 0.001) the gene expression to near control level when compared to hypoxia and epinephrine treatment which was supported by open field test.	Epinephrine	248-259	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	68-74
18598693-13	2008	These results suggest that the brain neuronal NOS/COX-1 and inducible NOS/COX-1 are respectively involved in the bombesin-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats.	Epinephrine	146-156	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	50-55
18598693-13	2008	These results suggest that the brain neuronal NOS/COX-1 and inducible NOS/COX-1 are respectively involved in the bombesin-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats.	Epinephrine	146-156	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	74-79
18505450-8	2008	At 0.3, 1.0 and 3.0 nmol/animal, GLP-1 dose-dependently elevated plasma levels of noradrenaline and adrenaline and the 1.0 nmol GLP-1-induced response was dose-dependently reduced by 5 and 10 nmol/animal exendin (5-39), a selective GLP-1 receptor antagonist.	Epinephrine	85-95	glucagon	Rattus norvegicus	33-38
18670087-3	2008	Of the compounds tested in human PRP, compounds 1, 8, and 10 showed significant inhibition of primary and secondary aggregation induced by epinephrine and had a weak inhibitory effect on cyclooxygenase-1 (COX-1).	Epinephrine	139-150	complement component 4 binding protein alpha	Homo sapiens	33-36
18505450-12	2008	The GLP-1-induced increase in plasma adrenaline concentrations was abolished by acute bilateral adrenalectomy, but the procedure had no effect on increases in plasma noradrenaline.	Epinephrine	37-47	glucagon	Rattus norvegicus	4-9
18505450-14	2008	These results suggest that, in rats, centrally administered GLP-1 induces the secretion of adrenaline from the adrenal medulla by brain thromboxane A(2)-mediated mechanisms, whereas the peptide evokes the release of noradrenaline from sympathetic nerves by brain prostanoids via mechanisms other than those mediated by thromboxane A(2).	Epinephrine	91-101	glucagon	Rattus norvegicus	60-65
18560370-9	2008	Finally, in vitro, we demonstrated that resveratrol (a Sirt1 activator) significantly enhanced the lipolytic effect of epinephrine in human adipose tissue (P&lt;0.05).	Epinephrine	119-130	sirtuin 1	Homo sapiens	55-60
18574075-5	2008	Intrabrachial infusion of epinephrine (0.1 to 0.3 microg/100 mL per minute) induced greater t-PA release in normotensive subjects as compared with essential hypertensive patients (P&lt;0.05).	Epinephrine	26-37	plasminogen activator, tissue type	Homo sapiens	92-96
18574075-6	2008	However, inhibition of NO synthase with N(G)-monomethyl-L-arginine (100 microg/100 mL per minute) infusion blunted epinephrine-induced t-PA release in normotensive subjects (P&lt;0.05) but not in essential hypertensive patients.	Epinephrine	115-126	plasminogen activator, tissue type	Homo sapiens	135-139
18574075-7	2008	In normotensive subjects, t-PA release by epinephrine was not affected by phentolamine (8 microg/100 mL per minute) coinfusion and was abolished in the presence of propanolol (10 microg/100 mL per minute).	Epinephrine	42-53	plasminogen activator, tissue type	Homo sapiens	26-30
18513370-1	2008	Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40).	Epinephrine	107-117	tyrosine hydroxylase	Homo sapiens	0-20
18641310-5	2008	Thus, low vs high epinephrine excretors had a 2- to 5-fold higher TNF-alpha and IL-12 production but 2-fold lower IL-10 production induced by LPS ex vivo.	Epinephrine	18-29	tumor necrosis factor	Homo sapiens	66-75
18641310-5	2008	Thus, low vs high epinephrine excretors had a 2- to 5-fold higher TNF-alpha and IL-12 production but 2-fold lower IL-10 production induced by LPS ex vivo.	Epinephrine	18-29	interleukin 10	Homo sapiens	114-119
18641310-8	2008	In human monocytes, epinephrine and the beta(2) adrenoreceptor agonist fenoterol potently inhibited LPS-induced TNF-alpha and IL-12, but stimulated IL-10 production.	Epinephrine	20-31	tumor necrosis factor	Homo sapiens	112-121
18641310-8	2008	In human monocytes, epinephrine and the beta(2) adrenoreceptor agonist fenoterol potently inhibited LPS-induced TNF-alpha and IL-12, but stimulated IL-10 production.	Epinephrine	20-31	interleukin 10	Homo sapiens	148-153
18513370-1	2008	Tyrosine hydroxylase (TH), the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline, is regulated acutely by feedback inhibition by the catecholamines and relief of this inhibition by phosphorylation of serine 40 (Ser40).	Epinephrine	107-117	tyrosine hydroxylase	Homo sapiens	22-24
18387001-7	2008	In additional experiments, PKC depletion by prolonged PMA treatment or PKCalpha antisense oligomers resulted in an increase in PKA activity in 3T3-F442A adipocytes, comparable with PKA activation with adrenaline (epinephrine) treatment.	Epinephrine	213-224	protein kinase C alpha	Homo sapiens	27-30
18597948-5	2008	UII, but not vehicle, increased HR significantly 60-90 min after treatment and increased plasma glucose at 60 and 90 min, both indicators of increased epinephrine release.	Epinephrine	151-162	urotensin 2	Rattus norvegicus	0-3
18597948-1	2008	Central administration of urotensin II (UII) increases heart rate (HR), cardiac contractility, and plasma levels of epinephrine and glucose.	Epinephrine	116-127	urotensin 2	Rattus norvegicus	26-38
18597948-1	2008	Central administration of urotensin II (UII) increases heart rate (HR), cardiac contractility, and plasma levels of epinephrine and glucose.	Epinephrine	116-127	urotensin 2	Rattus norvegicus	40-43
18480058-0	2008	The ATP-gated P2X1 receptor plays a pivotal role in activation of aspirin-treated platelets by thrombin and epinephrine.	Epinephrine	108-119	purinergic receptor P2X 1	Homo sapiens	14-27
18480058-3	2008	The results show that epinephrine acted via alpha(2A)-adrenergic receptors to provoke aggregation, secretion, and Ca(2+) mobilization in aspirin-treated platelets pre-stimulated with subthreshold concentrations of thrombin.	Epinephrine	22-33	coagulation factor II, thrombin	Homo sapiens	214-222
18480058-5	2008	Furthermore, platelets pre-exposed to the PAR4-activating peptide AYPGKF, but not to the PAR1-activating peptide SFLLRN, were aggregated by epinephrine, whereas both AYPGKF and SFLLRN synergized with epinephrine in the absence of aspirin.	Epinephrine	140-151	F2R like thrombin or trypsin receptor 3	Homo sapiens	42-46
18480058-5	2008	Furthermore, platelets pre-exposed to the PAR4-activating peptide AYPGKF, but not to the PAR1-activating peptide SFLLRN, were aggregated by epinephrine, whereas both AYPGKF and SFLLRN synergized with epinephrine in the absence of aspirin.	Epinephrine	200-211	F2R like thrombin or trypsin receptor 3	Homo sapiens	42-46
18480058-11	2008	Furthermore, in PAR4-pretreated platelets, epinephrine caused dense granule secretion, and subsequent signaling from the ATP-gated P2X(1)-receptor and the alpha(2A)-adrenergic receptor induced aggregation.	Epinephrine	43-54	F2R like thrombin or trypsin receptor 3	Homo sapiens	16-20
18480058-11	2008	Furthermore, in PAR4-pretreated platelets, epinephrine caused dense granule secretion, and subsequent signaling from the ATP-gated P2X(1)-receptor and the alpha(2A)-adrenergic receptor induced aggregation.	Epinephrine	43-54	purinergic receptor P2X 1	Homo sapiens	131-146
18480058-12	2008	These results suggest a new mechanism that has ATP as a key element and circumvents the action of aspirin on epinephrine-facilitated PAR4-mediated platelet activation.	Epinephrine	109-120	F2R like thrombin or trypsin receptor 3	Homo sapiens	133-137
18600088-5	2008	Also, it was demonstrated that epinephrine administration increases plasma von Willebrand factor levels in vivo.	Epinephrine	31-42	von Willebrand factor	Homo sapiens	75-96
18417737-4	2008	Here we show that RNAi-mediated knockdown of RalGDS, an exchange factor for Ral, results in inhibition of thrombin- and epinephrine-induced exocytosis of WPBs, while overexpression of RalGDS promotes exocytosis of WPBs.	Epinephrine	120-131	ral guanine nucleotide dissociation stimulator	Homo sapiens	45-51
18417737-4	2008	Here we show that RNAi-mediated knockdown of RalGDS, an exchange factor for Ral, results in inhibition of thrombin- and epinephrine-induced exocytosis of WPBs, while overexpression of RalGDS promotes exocytosis of WPBs.	Epinephrine	120-131	RAS like proto-oncogene A	Homo sapiens	45-48
18275042-0	2008	Epinephrine increases DNA synthesis via ERK1/2s through cAMP, Ca(2+)/PKC, and PI3K/Akt signaling pathways in mouse embryonic stem cells.	Epinephrine	0-11	mitogen-activated protein kinase 3	Mus musculus	40-46
18591701-1	2008	PURPOSE: To report the use of vasopressin to treat a patient who, after failing to respond to volume expansion and epinephrine administration, experienced an anaphylactic reaction to rocuronium.	Epinephrine	115-126	arginine vasopressin	Homo sapiens	30-41
18591701-9	2008	CONCLUSIONS: Vasopressin may be effective in the resuscitation of anesthetized patients, with hemodynamic instability associated with anaphylaxis resistant to epinephrine and alpha-agonists.	Epinephrine	159-170	arginine vasopressin	Homo sapiens	13-24
18275042-7	2008	In addition, we observed Akt phosphorylation in response to epinephrine; this was stimulated by phosphorylation of the epidermal growth factor receptor (EGFR).	Epinephrine	60-71	thymoma viral proto-oncogene 1	Mus musculus	25-28
18275042-0	2008	Epinephrine increases DNA synthesis via ERK1/2s through cAMP, Ca(2+)/PKC, and PI3K/Akt signaling pathways in mouse embryonic stem cells.	Epinephrine	0-11	thymoma viral proto-oncogene 1	Mus musculus	83-86
18275042-7	2008	In addition, we observed Akt phosphorylation in response to epinephrine; this was stimulated by phosphorylation of the epidermal growth factor receptor (EGFR).	Epinephrine	60-71	epidermal growth factor receptor	Mus musculus	119-151
18275042-5	2008	AR subtypes (alpha1(A), alpha2(A), beta1, beta2, and beta3) were expressed in mouse ESCs and their expression levels were increased by epinephrine.	Epinephrine	135-146	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	13-22
18275042-7	2008	In addition, we observed Akt phosphorylation in response to epinephrine; this was stimulated by phosphorylation of the epidermal growth factor receptor (EGFR).	Epinephrine	60-71	epidermal growth factor receptor	Mus musculus	153-157
18275042-8	2008	Epinephrine also induced phosphorylation of ERK1/2 (p44/42 MAPKs), while inhibition of PKC or Akt blocked this phosphorylation.	Epinephrine	0-11	mitogen-activated protein kinase 3	Mus musculus	44-50
18275042-5	2008	AR subtypes (alpha1(A), alpha2(A), beta1, beta2, and beta3) were expressed in mouse ESCs and their expression levels were increased by epinephrine.	Epinephrine	135-146	adrenergic receptor, alpha 2a	Mus musculus	24-33
18275042-8	2008	Epinephrine also induced phosphorylation of ERK1/2 (p44/42 MAPKs), while inhibition of PKC or Akt blocked this phosphorylation.	Epinephrine	0-11	mitogen-activated protein kinase 3	Mus musculus	52-55
18275042-5	2008	AR subtypes (alpha1(A), alpha2(A), beta1, beta2, and beta3) were expressed in mouse ESCs and their expression levels were increased by epinephrine.	Epinephrine	135-146	hemoglobin, beta adult major chain	Mus musculus	35-40
18275042-9	2008	Epinephrine increased the mRNA levels of proto-oncogenes (c-fos, c-jun, c-myc), while inhibition of ERK1/2 decreased these mRNA levels.	Epinephrine	0-11	FBJ osteosarcoma oncogene	Mus musculus	58-63
18275042-9	2008	Epinephrine increased the mRNA levels of proto-oncogenes (c-fos, c-jun, c-myc), while inhibition of ERK1/2 decreased these mRNA levels.	Epinephrine	0-11	jun proto-oncogene	Mus musculus	65-70
18275042-5	2008	AR subtypes (alpha1(A), alpha2(A), beta1, beta2, and beta3) were expressed in mouse ESCs and their expression levels were increased by epinephrine.	Epinephrine	135-146	hemoglobin, beta adult minor chain	Mus musculus	42-58
18275042-10	2008	In experiments aimed at examining the involvement of cell cycle regulatory proteins, epinephrine increased the levels of cyclin E/cyclin-dependent kinase 2 (CDK2) and cyclin D1/cyclin-dependent kinase 4 (CDK4).	Epinephrine	85-96	cyclin-dependent kinase 2	Mus musculus	157-161
18445123-3	2008	The catecholaminergic afferents of CRH and TRH neurones originate from both noradrenaline- and adrenaline-synthesising cell groups located in the brainstem, and collectively represent one of the most well studied neural inputs of these neurones.	Epinephrine	79-89	corticotropin releasing hormone	Rattus norvegicus	35-38
18275042-10	2008	In experiments aimed at examining the involvement of cell cycle regulatory proteins, epinephrine increased the levels of cyclin E/cyclin-dependent kinase 2 (CDK2) and cyclin D1/cyclin-dependent kinase 4 (CDK4).	Epinephrine	85-96	cyclin D1	Mus musculus	167-202
18275042-10	2008	In experiments aimed at examining the involvement of cell cycle regulatory proteins, epinephrine increased the levels of cyclin E/cyclin-dependent kinase 2 (CDK2) and cyclin D1/cyclin-dependent kinase 4 (CDK4).	Epinephrine	85-96	cyclin-dependent kinase 4	Mus musculus	204-208
18275042-11	2008	In conclusion, epinephrine stimulates DNA synthesis via ERK1/2 through cAMP, Ca(2+)/PKC, and PI3K/Akt signaling pathways in mouse ESCs.	Epinephrine	15-26	mitogen-activated protein kinase 3	Mus musculus	56-62
18275042-11	2008	In conclusion, epinephrine stimulates DNA synthesis via ERK1/2 through cAMP, Ca(2+)/PKC, and PI3K/Akt signaling pathways in mouse ESCs.	Epinephrine	15-26	thymoma viral proto-oncogene 1	Mus musculus	98-101
18467889-9	2008	Arginine vasopressin may be considered in patients presenting with asystole or who are unresponsive to initial treatment with epinephrine.	Epinephrine	126-137	arginine vasopressin	Homo sapiens	9-20
18566202-10	2008	CONCLUSION: A hypertensive response, following systemically absorbed topical vasoconstrictors, including both phenylephrine and epinephrine, can be associated with dire consequences when treated with a beta-adrenergic blocking drug and, possibly, calcium channel blockers.	Epinephrine	128-139	amyloid beta precursor protein	Homo sapiens	200-206
18349382-0	2008	Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release.	Epinephrine	88-99	phenylethanolamine N-methyltransferase	Homo sapiens	6-44
18375074-8	2008	In addition, OT treatment induced significantly higher increases in epinephrine plasma levels during sexual activity without affecting cortisol levels, prolactin levels or heart rate.	Epinephrine	68-79	oxytocin/neurophysin I prepropeptide	Homo sapiens	13-15
18349382-1	2008	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine from norepinephrine.	Epinephrine	73-84	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
18349382-1	2008	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the synthesis of epinephrine from norepinephrine.	Epinephrine	73-84	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
18349382-3	2008	In the present study, we set out to determine whether common PNMT genetic polymorphisms might be associated with individual variation in circulating epinephrine levels during exercise in 74 Caucasian American subjects.	Epinephrine	149-160	phenylethanolamine N-methyltransferase	Homo sapiens	61-65
18349382-10	2008	Our studies suggest that functionally significant variant sequence in the human PNMT gene might contribute to individual variation in levels of circulating epinephrine during exercise.	Epinephrine	156-167	phenylethanolamine N-methyltransferase	Homo sapiens	80-84
18370982-10	2008	When adjusted for severity of illness, patients who received albuterol were significantly more likely than patients receiving epinephrine to be successfully discharged (aRR = 1.18, 95% CI = 1.02 to 1.36).	Epinephrine	126-137	arrestin beta 1	Homo sapiens	169-176
18295358-3	2008	Reciprocal immunoprecipitations followed by Western blot analysis demonstrated that all PKC isozymes expressed in rat hepatocytes are modified by tyrosine nitration and tyrosine phosphorylation in different ways upon exposure of cells to a direct PKC activator (TPA), or to an extracellular ligand known to activate PKC-dependent pathways (epinephrine).	Epinephrine	340-351	protein kinase C, alpha	Rattus norvegicus	88-91
18300261-1	2008	The alpha(2A)-adrenoceptor (AR) subtype, a G protein-coupled receptor located both pre- and postsynaptically, mediates adrenaline/noradrenaline functions.	Epinephrine	119-129	adrenoceptor alpha 2A	Danio rerio	4-26
18300261-1	2008	The alpha(2A)-adrenoceptor (AR) subtype, a G protein-coupled receptor located both pre- and postsynaptically, mediates adrenaline/noradrenaline functions.	Epinephrine	119-129	adrenoceptor alpha 2A	Danio rerio	28-30
18294854-2	2008	hCA IX was activated efficiently by dopamine, adrenaline and heterocyclic amines possessing aminoethyl-/aminomethyl-moieties (K(A)s of 9 nM-1.07 microM), whereas the best hCA XII activators were serotonin, L-adrenaline, 4-(2-aminoethyl)-morpholine and d-Phe (K(A) of 0.24-0.41 microM).	Epinephrine	46-56	carbonic anhydrase 9	Homo sapiens	0-6
18294854-2	2008	hCA IX was activated efficiently by dopamine, adrenaline and heterocyclic amines possessing aminoethyl-/aminomethyl-moieties (K(A)s of 9 nM-1.07 microM), whereas the best hCA XII activators were serotonin, L-adrenaline, 4-(2-aminoethyl)-morpholine and d-Phe (K(A) of 0.24-0.41 microM).	Epinephrine	46-56	carbonic anhydrase 12	Homo sapiens	171-178
18294854-2	2008	hCA IX was activated efficiently by dopamine, adrenaline and heterocyclic amines possessing aminoethyl-/aminomethyl-moieties (K(A)s of 9 nM-1.07 microM), whereas the best hCA XII activators were serotonin, L-adrenaline, 4-(2-aminoethyl)-morpholine and d-Phe (K(A) of 0.24-0.41 microM).	Epinephrine	206-218	carbonic anhydrase 9	Homo sapiens	0-6
18294854-2	2008	hCA IX was activated efficiently by dopamine, adrenaline and heterocyclic amines possessing aminoethyl-/aminomethyl-moieties (K(A)s of 9 nM-1.07 microM), whereas the best hCA XII activators were serotonin, L-adrenaline, 4-(2-aminoethyl)-morpholine and d-Phe (K(A) of 0.24-0.41 microM).	Epinephrine	206-218	carbonic anhydrase 12	Homo sapiens	171-178
18307749-11	2008	There is induction of the adrenaline synthesizing enzyme, phenylethanolamine-N-methyltransferase, in sympathetic nerves, an explicit indicator of mental stress exposure.	Epinephrine	26-36	phenylethanolamine N-methyltransferase	Homo sapiens	58-96
18324973-2	2008	SS RBC adhesion to laminin increases in response to adrenaline stimulation of beta(2)-adrenergic receptors (beta(2)ARs) and adenylate cyclase (ADCY6), and previous evidence suggests such activation occurs in vivo.	Epinephrine	52-62	adenylate cyclase 6	Homo sapiens	143-148
18234185-5	2008	In the present experiment, therefore, we examined (1) a role of the brain 2-arachidonoyl-sn-glycerol as a precursor of arachidonic acid in the centrally administered vasopressin-induced elevation of plasma noradrenaline and adrenaline, and (2) a regulatory role of the brain 2-arachidonoyl-sn-glycerol as an endocannabinoid on the vasopressin-induced response, using urethane-anesthetized rats.	Epinephrine	209-219	arginine vasopressin	Rattus norvegicus	166-177
17889582-10	2008	Epinephrine was lower in the growth hormone group (2.8+/-0.2microg/l) compared to either controls (5.0+/-0.6microg/l, p=0.007), or to insulin-like growth factor-1-treated rats (6.3+/-0.6microg/l, p=0.0001).	Epinephrine	0-11	gonadotropin releasing hormone receptor	Rattus norvegicus	29-43
18290605-3	2008	The present study was designed to determine the effect of activation of adrenoceptor by epinephrine on MAP-2 phosphorylation in differentiation PC12 cells and, if so, to explore the mediating mechanism.	Epinephrine	88-99	microtubule-associated protein 2	Rattus norvegicus	103-108
18290605-5	2008	Differentiated PC12 cells express alpha 2A-adrenoceptor, whose antagonists could block these mentioned effects of epinephrine, and clonidine which is the agonist of alpha 2-adrenoceptor could mimic the effect of epinephrine.	Epinephrine	114-125	adrenoceptor alpha 2A	Rattus norvegicus	34-55
18290605-6	2008	Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.	Epinephrine	55-66	Eph receptor B1	Rattus norvegicus	28-31
18290605-6	2008	Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.	Epinephrine	140-151	Eph receptor B1	Rattus norvegicus	28-31
18290605-6	2008	Moreover phosphorylation of ERK and PKC was induced by epinephrine, and ERK and PKC specific inhibitors concentration-dependently prevented epinephrine-induced phosphorylation of MAP-2c at ser136.	Epinephrine	140-151	Eph receptor B1	Rattus norvegicus	72-75
18290605-8	2008	These findings suggest that epinephrine induces phosphorylation of MAP-2c at ser136 through a alpha 2-adrenoceptor mediated, ERK/PKC-dependent signaling pathway, which may contribute to the stabilization of neurites.	Epinephrine	28-39	Eph receptor B1	Rattus norvegicus	125-128
18278866-8	2008	TLL inhibited significantly ADP and epinephrine-induced platelet aggregation in a concentration-dependent manner (IC 50=0.40 and 0.32 mg/mL, respectively).	Epinephrine	36-47	tolloid like 1	Homo sapiens	0-3
18235090-1	2008	Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells.	Epinephrine	41-52	chromogranin A	Homo sapiens	0-14
18172836-8	2008	It was observed that both --+NH3 group and chiral --OH group of (-)-epinephrine interact with Asp106 TM III of alpha 1A-adrenoceptor.	Epinephrine	64-79	adrenoceptor alpha 1A	Bos taurus	111-132
18172836-10	2008	Enantiomers of epinephrine and oxymetazoline were also docked in the position at beta1-adrenoceptor to elucidate the conformational changes.	Epinephrine	15-26	adrenoceptor beta 1	Bos taurus	81-99
18299506-5	2008	METHODS AND RESULTS: We show here that circulating renalase lacks significant amine oxidase activity under basal conditions (prorenalase) but that a brief surge of epinephrine lasting &lt;2 minutes causes renalase activity to increase from 48+/-18 to 2246+/-98 arbitrary units (n=3; P&lt;0.002).	Epinephrine	164-175	renalase, FAD-dependent amine oxidase	Rattus norvegicus	51-59
17851960-7	2008	Those treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.	Epinephrine	122-133	toll-like receptor 4	Mus musculus	24-27
18207734-9	2008	Further experiments, in which insulin was replaced by H-89, revealed that the antilipolytic action of protein kinase A inhibitor on epinephrine-induced lipolysis was not affected by genistein.	Epinephrine	132-143	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	102-118
17977955-4	2008	RESULTS: In comparison with control studies, VMH AMPK downregulation resulted in suppressed glucagon ( approximately 60%) and epinephrine (approximately 40%) responses to acute hypoglycemia.	Epinephrine	126-137	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	49-53
17991876-8	2008	In addition, the mortality rate of EDA+/+ mice after collagen/epinephrine infusion was twice that of EDA(WT/WT) or EDA-/- mice.	Epinephrine	62-73	ectodysplasin-A	Mus musculus	35-38
18084319-8	2008	All effects of (-)-adrenaline were antagonized by the beta(1)-adrenoceptor-selective antagonist CGP20712A (300 nM).	Epinephrine	15-29	adrenergic receptor, beta 1	Mus musculus	54-74
17853072-0	2008	Acute stress or systemic insulin injection increases flunitrazepam sensitive-GABAA receptor density in synaptosomes of chick forebrain: Modulation by systemic epinephrine.	Epinephrine	159-170	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	77-91
17853072-10	2008	Similarly, the same epinephrine doses co-administered with insulin (2.50 IU/kg), increased the receptor density by about 20% compared to insulin alone.	Epinephrine	20-31	insulin	Gallus gallus	59-66
17853072-10	2008	Similarly, the same epinephrine doses co-administered with insulin (2.50 IU/kg), increased the receptor density by about 20% compared to insulin alone.	Epinephrine	20-31	insulin	Gallus gallus	137-144
17853072-11	2008	These results suggest that systemic epinephrine, perhaps by evoking central norepinephrine release, modulates the increase in forebrain GABAA receptor binding induced by both insulin and stress.	Epinephrine	36-47	gamma-aminobutyric acid type A receptor gamma3 subunit	Gallus gallus	136-150
17853072-11	2008	These results suggest that systemic epinephrine, perhaps by evoking central norepinephrine release, modulates the increase in forebrain GABAA receptor binding induced by both insulin and stress.	Epinephrine	36-47	insulin	Gallus gallus	175-182
17896794-2	2008	The rate-limiting step in the biosynthesis of dopamine, noradrenalin, and adrenalin is catalyzed by tyrosine 3-monooxygenase (=tyrosine hydroxylase), which catalyzes the formation of L-DOPA.	Epinephrine	59-68	tyrosine hydroxylase	Homo sapiens	100-124
18252001-6	2008	CONCLUSION: In case of anaphylactic shock, continuous infusion of low-dose vasopressin might be considered after inadequate response to epinephrine, fluid resuscitation and corticosteroid administration.	Epinephrine	136-147	arginine vasopressin	Homo sapiens	75-86
18084319-10	2008	CONCLUSIONS AND IMPLICATIONS: PDE4 blunts the beta(1)-adrenoceptor-mediated effects of (-)-adrenaline in left atrium and right ventricle but not in sinoatrial node.	Epinephrine	87-101	adrenergic receptor, beta 1	Mus musculus	46-66
18998072-4	2008	Not only insulin, but also insulin-like growth factor-I similarly decreased epinephrine-induced HGP.	Epinephrine	76-87	insulin-like growth factor 1	Rattus norvegicus	27-55
18386393-7	2008	Epinephrine (0.3-1.5 microg kg(-1) min(-1)) for 2 h increased SAP and CI (with higher stroke volume) and decreased pulmonary vascular resistance (with reduced PAP-SAP ratio), whereas the responses with dopamine (10-25 microg kg(-1) min(-1)) were modest.	Epinephrine	0-11	amyloid P component, serum	Sus scrofa	62-65
18386393-7	2008	Epinephrine (0.3-1.5 microg kg(-1) min(-1)) for 2 h increased SAP and CI (with higher stroke volume) and decreased pulmonary vascular resistance (with reduced PAP-SAP ratio), whereas the responses with dopamine (10-25 microg kg(-1) min(-1)) were modest.	Epinephrine	0-11	amyloid P component, serum	Sus scrofa	163-166
18003720-7	2008	Basal and epinephrine-stimulated activity of muscle glycogen phosphorylase was comparable between wild-type and GSK3 knockin mice.	Epinephrine	10-21	muscle glycogen phosphorylase	Mus musculus	45-74
18257750-0	2008	Peripheral administration of CDP-choline, phosphocholine or choline increases plasma adrenaline and noradrenaline concentrations.	Epinephrine	85-95	cut like homeobox 1	Homo sapiens	29-32
18257750-2	2008	injection of 200-600 mumol/kg of cytidine-5"-diphosphocholine (CDP-choline) increased plasma adrenaline and noradrenaline concentrations dose- and time-dependently.	Epinephrine	93-103	cut like homeobox 1	Homo sapiens	63-66
18214744-2	2008	MATERIALS AND METHODS: Obestatin (10(-5) M) or ghrelin (10(-5) M) were tested on two consecutive carbachol-or epinephrine-elicited contractions of iris rabbit sphincter or dilator muscles.	Epinephrine	110-121	LOC100101616	Oryctolagus cuniculus	47-54
18078856-6	2008	In the presence of a minimally effective glucose level (10 mmol/L), mouse islets remain exquisitely sensitive to the combined stimulatory effects of GLP-1 (2.5 nmol/L) plus carbachol (0.5 micromol/L) and to the inhibitory influence of epinephrine (10 nmol/L).	Epinephrine	235-246	glucagon	Mus musculus	149-154
18514010-4	2008	Stimulation of SS RBCs by epinephrine activates the PKA depending signaling pathway and induces reinforced Lu/BCAM-mediated adhesion to laminin10/11.	Epinephrine	26-37	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	110-114
18515167-9	2008	Interestingly, Lu/BCAM- and ICAM-4-mediated adhesion are enhanced by the stress mediator epinephrine through a PKA-dependent pathway initiated by a rise in intracellular cAMP and leading to receptor activation by phosphorylation according to the same signaling pathway.	Epinephrine	89-100	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	18-22
18515167-9	2008	Interestingly, Lu/BCAM- and ICAM-4-mediated adhesion are enhanced by the stress mediator epinephrine through a PKA-dependent pathway initiated by a rise in intracellular cAMP and leading to receptor activation by phosphorylation according to the same signaling pathway.	Epinephrine	89-100	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	28-34
18056263-0	2008	Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.	Epinephrine	3-14	adrenoceptor beta 2	Homo sapiens	49-67
18056263-0	2008	Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes.	Epinephrine	3-14	G protein-coupled receptor kinase 2	Homo sapiens	93-97
17975121-3	2008	METHODS AND RESULTS: Norepinephrine and epinephrine, added to aortic smooth muscle cells (ASMCs) in vitro, altered Per1, E4bp4, and dbp expression and altered the observed oscillations in clock gene expression.	Epinephrine	24-35	nuclear factor, interleukin 3, regulated	Mus musculus	121-126
17975121-3	2008	METHODS AND RESULTS: Norepinephrine and epinephrine, added to aortic smooth muscle cells (ASMCs) in vitro, altered Per1, E4bp4, and dbp expression and altered the observed oscillations in clock gene expression.	Epinephrine	24-35	D site albumin promoter binding protein	Mus musculus	132-135
18257750-21	2008	administration of CDP-choline or its cholinergic metabolites phosphocholine and choline increases plasma adrenaline and noradrenaline concentrations by enhancing nicotinic cholinergic neurotransmission in the sympatho-adrenal system.	Epinephrine	105-115	cut like homeobox 1	Homo sapiens	18-21
19012528-1	2008	BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise.	Epinephrine	28-38	interleukin 6	Homo sapiens	118-131
19012528-1	2008	BACKGROUND: Biogenic amine, adrenaline, noradrenaline, dopamine and 5-hydroxy-tryptamine (5-HT) levels are related to interleukin-6 (IL-6) plasma concentrations and endurance exercise.	Epinephrine	28-38	interleukin 6	Homo sapiens	133-137
18094670-3	2008	In this syndrome, we believe that high levels of circulating epinephrine trigger a switch in intracellular signal trafficking in ventricular cardiomyocytes, from G(s) protein to G(i) protein signaling via the beta(2)-adrenoceptor.	Epinephrine	61-72	adrenoceptor beta 2	Homo sapiens	209-229
17853069-3	2008	Also, in the adrenal glands basal levels of tyrosine hydroxylase protein, the rate-limiting enzyme for catecholamine biosynthesis, and of phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine, were significantly reduced in nNOS KO mice.	Epinephrine	196-207	phenylethanolamine-N-methyltransferase	Mus musculus	138-176
17853069-7	2008	These data suggest that the chronic absence of nNOS reduces the capacity of epinephrine synthesising enzymes in the adrenal gland to respond to acute stressor exposure with an adequate epinephrine release.	Epinephrine	76-87	nitric oxide synthase 1, neuronal	Mus musculus	47-51
17853069-7	2008	These data suggest that the chronic absence of nNOS reduces the capacity of epinephrine synthesising enzymes in the adrenal gland to respond to acute stressor exposure with an adequate epinephrine release.	Epinephrine	185-196	nitric oxide synthase 1, neuronal	Mus musculus	47-51
18096057-0	2007	The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment.	Epinephrine	102-113	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	16-21
17711984-3	2007	That dose of insulin raised plasma insulin concentrations approximately threefold, suppressed glucose production, and drove plasma glucose concentrations down to subphysiological levels (65 +/- 3 mg/dl, P &lt; 0.0001 vs. saline), resulting in nearly complete suppression of insulin secretion (P &lt; 0.0001) and stimulation of glucagon (P = 0.0059) and epinephrine (P = 0.0009) secretion.	Epinephrine	353-364	insulin	Homo sapiens	13-20
19300629-1	2007	A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits.	Epinephrine	163-174	catechol-O-methyltransferase	Homo sapiens	49-76
19300629-1	2007	A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is associated with cognitive deficits.	Epinephrine	163-174	catechol-O-methyltransferase	Homo sapiens	78-82
17855349-2	2007	We found that epinephrine significantly increases eNOS activity in cultured bovine aortic endothelial cells (BAEC).	Epinephrine	14-25	nitric oxide synthase 3	Bos taurus	50-54
17855349-3	2007	Epinephrine-dependent eNOS activation was accompanied by an increase in phosphorylation of eNOS at Ser(1179) and with decreased eNOS phosphorylation at the inhibitory phosphoresidues Ser(116) and Thr(497).	Epinephrine	0-11	nitric oxide synthase 3	Bos taurus	22-26
17855349-3	2007	Epinephrine-dependent eNOS activation was accompanied by an increase in phosphorylation of eNOS at Ser(1179) and with decreased eNOS phosphorylation at the inhibitory phosphoresidues Ser(116) and Thr(497).	Epinephrine	0-11	nitric oxide synthase 3	Bos taurus	91-95
17855349-3	2007	Epinephrine-dependent eNOS activation was accompanied by an increase in phosphorylation of eNOS at Ser(1179) and with decreased eNOS phosphorylation at the inhibitory phosphoresidues Ser(116) and Thr(497).	Epinephrine	0-11	nitric oxide synthase 3	Bos taurus	91-95
17855349-4	2007	Epinephrine promoted activation of the small G protein Rac1 and also led to the activation of protein kinase A.	Epinephrine	0-11	Rac family small GTPase 1	Bos taurus	55-59
17855349-8	2007	However, siRNA-mediated knockdown of PKA did not affect Rac1 activation by epinephrine but did attenuate Akt activation by epinephrine.	Epinephrine	123-134	AKT serine/threonine kinase 1	Bos taurus	105-108
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	120-131	cyclin dependent kinase inhibitor 1A	Bos taurus	17-20
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	120-131	Rac family small GTPase 1	Bos taurus	100-104
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	120-131	nitric oxide synthase 3	Bos taurus	162-166
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	120-131	Rac family small GTPase 1	Bos taurus	172-176
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	120-131	Rac family small GTPase 1	Bos taurus	172-176
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	178-189	cyclin dependent kinase inhibitor 1A	Bos taurus	17-20
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	178-189	Rac family small GTPase 1	Bos taurus	100-104
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	178-189	nitric oxide synthase 3	Bos taurus	162-166
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	178-189	Rac family small GTPase 1	Bos taurus	172-176
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	178-189	nitric oxide synthase 3	Bos taurus	201-205
17855349-10	2007	We exploited the p21-activated kinase pulldown assay to identify proteins associated with activated Rac1 and found that epinephrine stimulated the association of eNOS with Rac1; epinephrine-stimulated eNOS-Rac1 interactions were blocked by the beta(3)AR antagonist SR59230A.	Epinephrine	178-189	Rac family small GTPase 1	Bos taurus	172-176
17855349-12	2007	We also found that epinephrine-induced Rac1 --&gt; PKA --&gt; Akt pathway mediates beta(3)AR-mediated endothelial cell migration.	Epinephrine	19-30	Rac family small GTPase 1	Bos taurus	39-43
17855349-12	2007	We also found that epinephrine-induced Rac1 --&gt; PKA --&gt; Akt pathway mediates beta(3)AR-mediated endothelial cell migration.	Epinephrine	19-30	AKT serine/threonine kinase 1	Bos taurus	62-65
17699566-2	2007	The present study tested the hypothesis that LTH selectively reduces adrenomedullary expression of phenylethanolamine-N-methyltransferase (PNMT), the rate-limiting enzyme for epinephrine synthesis.	Epinephrine	175-186	phenylethanolamine N-methyltransferase	Ovis aries	99-137
17699566-2	2007	The present study tested the hypothesis that LTH selectively reduces adrenomedullary expression of phenylethanolamine-N-methyltransferase (PNMT), the rate-limiting enzyme for epinephrine synthesis.	Epinephrine	175-186	phenylethanolamine N-methyltransferase	Ovis aries	139-143
17628524-2	2007	administered histamine evokes the secretion of noradrenaline and adrenaline from adrenal medulla by brain cyclooxygenase-1- and thromboxane A2-mediated mechanisms in rats.	Epinephrine	50-60	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	106-122
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Epinephrine	62-73	interleukin 6	Mus musculus	19-23
17974982-10	2007	These studies show IL-6-independent activation of STAT3 by norepinephrine and epinephrine, proceeding through the beta1/beta2-adrenergic receptors and protein kinase A, resulting in increased matrix metalloproteinase production, invasion, and in vivo tumor growth, which can be ameliorated by the down-regulation of STAT3.	Epinephrine	62-73	signal transducer and activator of transcription 3	Mus musculus	50-55
18274160-8	2007	Power spectrum of the ENG recorded with GTE 9, contained frequencies belonging to the neural activity elicited by compression of the carotid artery and injection of epinephrine.	Epinephrine	165-176	endoglin	Canis lupus familiaris	22-25
17573135-10	2007	Adrenaline, noradrenaline, endothelin and secretin stimulated ghrelin release, while somatostatin and GRP inhibited.	Epinephrine	0-10	ghrelin and obestatin prepropeptide	Rattus norvegicus	62-69
17609430-6	2007	Epinephrine-induced SS RBC adhesion, vaso-occlusion, and RBC organ trapping could be prevented by the beta-adrenergic receptor (beta-AR) antagonist, propranolol.	Epinephrine	0-11	adrenergic receptor, beta 1	Mus musculus	102-126
17609430-6	2007	Epinephrine-induced SS RBC adhesion, vaso-occlusion, and RBC organ trapping could be prevented by the beta-adrenergic receptor (beta-AR) antagonist, propranolol.	Epinephrine	0-11	adrenergic receptor, beta 1	Mus musculus	128-135
17609430-9	2007	We conclude that LW activation by epinephrine via beta-AR stimulation can promote both SS RBC and leukocyte adhesion as well as vaso-occlusion, suggesting that both epinephrine and LW play potentially pathophysiological roles in SCD.	Epinephrine	34-45	adrenergic receptor, beta 1	Mus musculus	50-57
17609430-9	2007	We conclude that LW activation by epinephrine via beta-AR stimulation can promote both SS RBC and leukocyte adhesion as well as vaso-occlusion, suggesting that both epinephrine and LW play potentially pathophysiological roles in SCD.	Epinephrine	165-176	adrenergic receptor, beta 1	Mus musculus	50-57
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Epinephrine	55-66	signal transducer and activator of transcription 3	Mus musculus	105-155
17974982-2	2007	We examined the effects of two mediators of stress, norepinephrine and epinephrine, on the activation of signal transducer and activator of transcription-3 (STAT3), a transcription factor that contributes to many promalignant pathways.	Epinephrine	55-66	signal transducer and activator of transcription 3	Mus musculus	157-162
17974982-3	2007	Exposure of ovarian cancer cell lines to increasing concentrations of norepinephrine or epinephrine showed that both independently increased levels of phosphorylated STAT3 in a dose-dependent fashion.	Epinephrine	73-84	signal transducer and activator of transcription 3	Mus musculus	166-171
17702852-7	2007	In summary, infusion of IGF-I in late gestation resulted in a marked hypertrophy of the steroidogenic and adrenaline-containing cells of the fetal adrenal in the absence of changes in the mRNA levels of adrenal steroidogenic or catecholamine-synthetic enzymes or in fetal plasma cortisol concentrations.	Epinephrine	106-116	insulin-like growth factor I	Ovis aries	24-29
17680988-4	2007	On the other hand, treatment of the cells with epinephrine caused activation of protein kinase A (PKA), which was fully abolished by ketoconazole.	Epinephrine	47-58	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	80-96
17680988-4	2007	On the other hand, treatment of the cells with epinephrine caused activation of protein kinase A (PKA), which was fully abolished by ketoconazole.	Epinephrine	47-58	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	98-101
17680988-5	2007	Inhibition of PKA activity with H89 or ketoconazole abolished the effects of epinephrine on CREB, suggesting that activation of the cAMP/PKA pathway by AA epoxy-derivatives is responsible for CREB activation by alpha2-ARs.	Epinephrine	77-88	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	14-17
17680988-5	2007	Inhibition of PKA activity with H89 or ketoconazole abolished the effects of epinephrine on CREB, suggesting that activation of the cAMP/PKA pathway by AA epoxy-derivatives is responsible for CREB activation by alpha2-ARs.	Epinephrine	77-88	cAMP responsive element binding protein 1	Rattus norvegicus	92-96
17680988-5	2007	Inhibition of PKA activity with H89 or ketoconazole abolished the effects of epinephrine on CREB, suggesting that activation of the cAMP/PKA pathway by AA epoxy-derivatives is responsible for CREB activation by alpha2-ARs.	Epinephrine	77-88	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	137-140
17680988-5	2007	Inhibition of PKA activity with H89 or ketoconazole abolished the effects of epinephrine on CREB, suggesting that activation of the cAMP/PKA pathway by AA epoxy-derivatives is responsible for CREB activation by alpha2-ARs.	Epinephrine	77-88	cAMP responsive element binding protein 1	Rattus norvegicus	192-196
17885681-5	2007	In cultured cardiomyocytes, knockdown of cardiac-MLCK by specific siRNAs decreased MLC2v phosphorylation and impaired epinephrine-induced activation of sarcomere reassembly.	Epinephrine	118-129	myosin light chain kinase 3	Homo sapiens	41-53
18079609-3	2007	Moreover, the UCP induction was accelerated by triiodothyronine (T3) or epinephrine, and reached a maximum at 2 h. It appeared that the induction of UCP mRNA and protein was rapid.	Epinephrine	72-83	uncoupling protein 1	Rattus norvegicus	14-17
18079609-6	2007	UCP-3 expression was more markedly increased by epinephrine than by T3.	Epinephrine	48-59	uncoupling protein 3	Rattus norvegicus	0-5
17705531-1	2007	In this work, the interactions between the main catecholamines-epinephrine and norepinephrine-and fibrinogen were investigated by NMR and Fourier transform infrared spectroscopies.	Epinephrine	63-74	fibrinogen beta chain	Homo sapiens	98-108
17664025-1	2007	Alpha2-adrenoceptors belong to the group of nine adrenoceptors which mediate the biological actions of the endogenous catecholamines adrenaline and noradrenaline.	Epinephrine	133-143	adrenergic receptor, alpha 2a	Mus musculus	0-20
17632098-8	2007	U46619- or collagen plus epinephrine-induced platelet pulmonary thromboembolism in mice was reduced by NCX 6560 at 46.8 mg/kg p.o.	Epinephrine	25-36	T cell leukemia, homeobox 2	Mus musculus	103-106
17766707-0	2007	Reduced epinephrine reserve in response to insulin-induced hypoglycemia in patients with pituitary adenoma.	Epinephrine	8-19	insulin	Homo sapiens	43-50
17597596-2	2007	Recent experiments in gene-targeted mice have suggested that alpha(2C)-adrenoceptors may operate in a similar feedback mechanism to control the release of epinephrine from the adrenal medulla.	Epinephrine	155-166	adrenergic receptor, alpha 2c	Mus musculus	61-69
17597596-6	2007	Urinary excretion of epinephrine was increased by 74+/-15% in alpha(2C)+/- and by 142+/-23% in alpha(2C)-/- mice as compared with wild-type control mice.	Epinephrine	21-32	adrenergic receptor, alpha 2c	Mus musculus	62-70
17597596-6	2007	Urinary excretion of epinephrine was increased by 74+/-15% in alpha(2C)+/- and by 142+/-23% in alpha(2C)-/- mice as compared with wild-type control mice.	Epinephrine	21-32	adrenergic receptor, alpha 2c	Mus musculus	95-103
17597596-10	2007	A single adrenoceptor subtype, alpha(2C), operates without a significant receptor reserve to prevent elevation of circulating epinephrine levels.	Epinephrine	126-137	adrenergic receptor, alpha 2c	Mus musculus	31-39
17766707-6	2007	RESULTS: The study patients showed diminished response of plasma epinephrine to insulin-induced hypoglycemia.	Epinephrine	65-76	insulin	Homo sapiens	80-87
17766707-8	2007	Peak epinephrine levels to insulin-induced hypoglycemia were significantly correlated with peak cortisol levels.	Epinephrine	5-16	insulin	Homo sapiens	27-34
17766707-10	2007	CONCLUSIONS: Impaired epinephrine secretion in response to insulin-induced hypoglycemia was frequently observed in patients with pituitary adenoma.	Epinephrine	22-33	insulin	Homo sapiens	59-66
17206434-6	2007	For condition after CPR we found an adrenaline/noradrenaline quotient of 2.81 +/- 5.8.	Epinephrine	36-46	cytochrome p450 oxidoreductase	Homo sapiens	20-23
17698731-0	2007	Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Mus musculus	77-115
17805088-7	2007	Coingestion of CAF/CHO significantly attenuated epinephrine (P&lt;0.05) and IL-6 (P&lt;0.05) responses that occurred after ingestion of CAF alone (CAF/PLA) and significantly attenuated the transient alterations in circulating leukocyte (P&lt;0.05) and neutrophil (P&lt;0.01) counts.	Epinephrine	48-59	lysine acetyltransferase 2B	Homo sapiens	15-18
17683411-2	2007	We report a case of severe bradycardia associated with anaphylactic shock after aprotinin in a beta-blocked child, which was resistant to intravenous epinephrine and vascular filling but was treated successfully with isoproterenol.	Epinephrine	150-161	amyloid beta precursor protein	Homo sapiens	93-99
17876988-2	2007	Antidepressants enhance monoamine, such as serotonin, nor adrenaline and dopamine neurotransmission by blockade of monoamine transporter or monoamine oxydase.	Epinephrine	58-68	solute carrier family 18 member A2	Homo sapiens	115-136
17698731-3	2007	METHODS AND RESULTS: An epinephrine-deficient mouse model was generated in which the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase was knocked out (KO).	Epinephrine	24-35	phenylethanolamine-N-methyltransferase	Mus musculus	117-155
17663734-7	2007	A limited genotype analysis demonstrated that the C825T polymorphism of GNB3 was associated with the platelet aggregation response to 2 muM epinephrine, but the effect differed by race.	Epinephrine	140-151	G protein subunit beta 3	Homo sapiens	72-76
17482796-12	2007	In vivo, PDE3A KO mice were protected against collagen/epinephrine-induced pulmonary thrombosis and death, while no such protection was observed in PDE3B KO mice.	Epinephrine	55-66	phosphodiesterase 3A, cGMP inhibited	Mus musculus	9-14
19356039-1	2007	Three neurotransmitters, namely adrenaline, serotonin and tryptamine inhibit the in vitro activity of several cytochrome P450 (CYP) isozymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A).	Epinephrine	32-42	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	142-148
19356039-1	2007	Three neurotransmitters, namely adrenaline, serotonin and tryptamine inhibit the in vitro activity of several cytochrome P450 (CYP) isozymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A).	Epinephrine	32-42	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	150-156
19356039-1	2007	Three neurotransmitters, namely adrenaline, serotonin and tryptamine inhibit the in vitro activity of several cytochrome P450 (CYP) isozymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A).	Epinephrine	32-42	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	158-164
19356039-1	2007	Three neurotransmitters, namely adrenaline, serotonin and tryptamine inhibit the in vitro activity of several cytochrome P450 (CYP) isozymes (CYP1A2, CYP2C9, CYP2D6 and CYP3A).	Epinephrine	32-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	169-174
19356039-4	2007	However, the effect became negligible when adrenaline concentration was decreased to 100 microM: whereas a high inhibitory effect was observed in CYP2D6, CYP2C9 and CYP3A4 enzyme activities, the NADPH reductase activity remains unchanged.	Epinephrine	43-53	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	146-152
19356039-4	2007	However, the effect became negligible when adrenaline concentration was decreased to 100 microM: whereas a high inhibitory effect was observed in CYP2D6, CYP2C9 and CYP3A4 enzyme activities, the NADPH reductase activity remains unchanged.	Epinephrine	43-53	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	154-160
19356039-4	2007	However, the effect became negligible when adrenaline concentration was decreased to 100 microM: whereas a high inhibitory effect was observed in CYP2D6, CYP2C9 and CYP3A4 enzyme activities, the NADPH reductase activity remains unchanged.	Epinephrine	43-53	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	165-171
17472573-5	2007	Secretion in response to thrombin, a protease-activated receptor-1 agonist peptide, histamine, forskolin and adrenaline (epinephrine) was inhibited.	Epinephrine	109-119	coagulation factor II, thrombin	Homo sapiens	25-33
17472573-5	2007	Secretion in response to thrombin, a protease-activated receptor-1 agonist peptide, histamine, forskolin and adrenaline (epinephrine) was inhibited.	Epinephrine	121-132	coagulation factor II, thrombin	Homo sapiens	25-33
17472573-5	2007	Secretion in response to thrombin, a protease-activated receptor-1 agonist peptide, histamine, forskolin and adrenaline (epinephrine) was inhibited.	Epinephrine	121-132	coagulation factor II thrombin receptor	Homo sapiens	37-66
17490904-6	2007	Adrenaline increases the Ca2+ activity participating in activation, but doing this by elevating perfusate Ca2+ from 1.5 to 5 mM instead of applying adrenaline did not change the mechanical efficiency, although afterload was maximized.	Epinephrine	0-10	carbonic anhydrase II	Oncorhynchus mykiss	25-28
17663734-7	2007	A limited genotype analysis demonstrated that the C825T polymorphism of GNB3 was associated with the platelet aggregation response to 2 muM epinephrine, but the effect differed by race.	Epinephrine	140-151	latexin	Homo sapiens	136-139
17646643-5	2007	Here, we tested pharmacological manipulation with epinephrine to restore functional transport of P-GUS across the adult BBB.	Epinephrine	50-61	glucuronidase, beta	Mus musculus	99-102
17646643-12	2007	Thus, the effect of epinephrine on the transport of (131)I-P-GUS was ligand specific.	Epinephrine	20-31	glucuronidase, beta	Mus musculus	61-64
17646643-13	2007	These results indicate that epinephrine restores the M6P receptor-mediated functional transport of (131)I-P-GUS across the BBB in adults to levels seen in the neonate.	Epinephrine	28-39	glucuronidase, beta	Mus musculus	108-111
17645789-2	2007	One candidate gene is PNMT, coding for phenylethanolamine-N-methyltransferase, catalyzing the synthesis of epinephrine from norepinephrine.	Epinephrine	107-118	phenylethanolamine N-methyltransferase	Homo sapiens	22-26
17631100-3	2007	The nano-Au/PPyox/GCE had strongly catalytic activity toward the oxidation of epinephrine (EP), uric acid (UA) and ascorbic acid (AA), and resolved the overlapping voltammetric response of EP, UA and AA into three well-defined peaks with a large anodic peak difference.	Epinephrine	78-89	aminomethyltransferase	Homo sapiens	18-21
17631100-7	2007	The nano-Au/PPyox/GCE has been applied to determination of EP in epinephrine hydrochloride injection and UA in urine samples with satisfactory results.	Epinephrine	65-90	aminomethyltransferase	Homo sapiens	18-21
17645789-2	2007	One candidate gene is PNMT, coding for phenylethanolamine-N-methyltransferase, catalyzing the synthesis of epinephrine from norepinephrine.	Epinephrine	107-118	phenylethanolamine N-methyltransferase	Homo sapiens	39-77
17645789-9	2007	The identified variation pattern of PNMT reflects the effect of purifying selection consistent with an important role of PNMT-synthesized epinephrine in the regulation of cardiovascular and metabolic functions, and as a CNS neurotransmitter.	Epinephrine	138-149	phenylethanolamine N-methyltransferase	Homo sapiens	36-40
17645789-9	2007	The identified variation pattern of PNMT reflects the effect of purifying selection consistent with an important role of PNMT-synthesized epinephrine in the regulation of cardiovascular and metabolic functions, and as a CNS neurotransmitter.	Epinephrine	138-149	phenylethanolamine N-methyltransferase	Homo sapiens	121-125
17645789-13	2007	The role of these elements in regulating PNMT expression patterns and thus determining the dynamics of the synthesis of epinephrine is still to be studied.	Epinephrine	120-131	phenylethanolamine N-methyltransferase	Homo sapiens	41-45
17625001-12	2007	The adrenal medulla harboured numerous CART IR endocrine cells, most of which were adrenaline producing.	Epinephrine	83-93	CART prepropeptide	Mus musculus	39-43
17625001-18	2007	CONCLUSION: CART is a major neuropeptide in intrinsic neurons of the porcine GI-tract and pancreas, a major constituent of adrenaline producing adrenomedullary cells, and a novel peptide of the thyroid C-cells.	Epinephrine	123-133	CART prepropeptide	Mus musculus	12-16
17512257-2	2007	Local administration of alphabeta-methyleneATP (ligand for P2X3/P2X2/3 receptors) into the plantar hind paw produced few pain behaviors when given alone in this strain of rats; combination with adrenaline (alpha1- and alpha2-AR agonist) and phenylephrine (alpha1-AR agonist) but not clonidine or UK 14,304 (alpha2-AR agonists) increased flinching behaviors.	Epinephrine	194-204	purinergic receptor P2X 3	Rattus norvegicus	59-63
17525370-8	2007	Furthermore, administration of epinephrine induced frequent ventricular extrasystoles and ventricular tachycardia in S105N Rad transgenic mice.	Epinephrine	31-42	Ras-related associated with diabetes	Mus musculus	123-126
17544884-9	2007	Epinephrine resulted in increased cardiac output (4.4-6.9 L/min, p &lt; 0.01) and mBP (72.7-89.1 mmHg, p &lt; 0.01), whereas vein graft flow was reduced in 6 of 12 patients.	Epinephrine	0-11	myelin basic protein	Mus musculus	82-85
17541557-4	2007	For this purpose, we assessed in 82 patients, who were preoperatively chronically treated with metoprolol, after CABG surgery with CPB, the dose and duration of adrenaline-induced inotropic support in relation to the Arg389Gly-beta(1)AR genotype.	Epinephrine	161-171	adrenoceptor beta 1	Homo sapiens	227-236
17448453-1	2007	OBJECTIVE: Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart.	Epinephrine	86-97	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	11-49
17448453-1	2007	OBJECTIVE: Phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine (EPI) from norepinephrine (NE) in the adrenal gland, is present in extra-adrenal tissues including heart.	Epinephrine	86-97	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	51-55
17394575-12	2007	In this work, we used corticotropin-releasing hormone (CRH) knockout mice, where secretion of corticosterone and subsequently adrenaline is significantly suppressed.	Epinephrine	126-136	corticotropin releasing hormone	Mus musculus	22-53
17394575-12	2007	In this work, we used corticotropin-releasing hormone (CRH) knockout mice, where secretion of corticosterone and subsequently adrenaline is significantly suppressed.	Epinephrine	126-136	corticotropin releasing hormone	Mus musculus	55-58
17394575-13	2007	As no increase in NCX1 mRNA was observed in CRH knockout mice due to immobilization stress, we proposed that adrenaline (probably regulated via corticosterone) is involved in the regulation of NCX1 gene expression during stress.	Epinephrine	109-119	T cell leukemia, homeobox 2	Mus musculus	193-197
17398109-10	2007	In addition preoperative basal CD11b expression correlated with adrenaline requirements and intra-aortic balloon pump usage.	Epinephrine	64-74	integrin subunit alpha M	Homo sapiens	31-36
17457889-1	2007	Catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme.	Epinephrine	29-40	tyrosine hydroxylase	Mus musculus	110-130
17457889-1	2007	Catecholamines (dopamine, norepinephrine, and epinephrine) are all synthesized from a common pathway in which tyrosine hydroxylase (TH) is the rate-limiting enzyme.	Epinephrine	29-40	tyrosine hydroxylase	Mus musculus	132-134
17253964-0	2007	Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes.	Epinephrine	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	60-88
17417063-7	2007	Interactions between catechol-o-methyltransferase polymorphism and diagnostic group in measures of plasma epinephrine, cortisol and subjective responses to psychological stress were also found, with the influence of the different alleles on these measures differing between healthy controls relative to MDD patients and high risk probands.	Epinephrine	106-117	catechol-O-methyltransferase	Homo sapiens	21-49
17253964-2	2007	Since adrenaline (epinephrine) concentrations increase with exercise, in the present study we hypothesized that adrenaline activates AMPK in adipocytes.	Epinephrine	6-16	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	133-137
17253964-2	2007	Since adrenaline (epinephrine) concentrations increase with exercise, in the present study we hypothesized that adrenaline activates AMPK in adipocytes.	Epinephrine	18-29	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	133-137
17253964-2	2007	Since adrenaline (epinephrine) concentrations increase with exercise, in the present study we hypothesized that adrenaline activates AMPK in adipocytes.	Epinephrine	112-122	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	133-137
17253964-4	2007	Similarly to exercise, adrenaline treatment in vivo increased AMPK activities and ACC phosphorylation.	Epinephrine	23-33	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	62-66
17253964-7	2007	Adrenaline incubation of isolated adipocytes also increased the AMP/ATP ratio and AMPK activities, an effect blocked by propranolol.	Epinephrine	0-10	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	82-86
17253964-11	2007	Our findings suggest that adrenaline plays a critical role in exercise-stimulated AMPKalpha1 and alpha2 activities in adipocytes, and that AMPK can function in the regulation of lipolysis.	Epinephrine	26-36	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	82-92
17253964-11	2007	Our findings suggest that adrenaline plays a critical role in exercise-stimulated AMPKalpha1 and alpha2 activities in adipocytes, and that AMPK can function in the regulation of lipolysis.	Epinephrine	26-36	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	82-86
17257813-6	2007	PP1-GM activity and the amount of PP1 bound to GM decreased 40% and 45% respectively, in response to adrenaline in control mice.	Epinephrine	101-111	protein phosphatase 1 catalytic subunit gamma	Mus musculus	0-3
17257813-6	2007	PP1-GM activity and the amount of PP1 bound to GM decreased 40% and 45% respectively, in response to adrenaline in control mice.	Epinephrine	101-111	protein phosphatase 1 catalytic subunit gamma	Mus musculus	34-37
17257813-7	2007	The data support a model in which adrenaline stimulates phosphorylation of phosphorylase Ser14 and GS Ser7 in GM+/+ mice by both kinase activation and PP1-GM inhibition and the phosphorylation of GS Ser640 and Ser640/644 by PP1-GM inhibition alone.	Epinephrine	34-44	protein phosphatase 1 catalytic subunit gamma	Mus musculus	151-154
17257813-7	2007	The data support a model in which adrenaline stimulates phosphorylation of phosphorylase Ser14 and GS Ser7 in GM+/+ mice by both kinase activation and PP1-GM inhibition and the phosphorylation of GS Ser640 and Ser640/644 by PP1-GM inhibition alone.	Epinephrine	34-44	protein phosphatase 1 catalytic subunit gamma	Mus musculus	224-227
17653469-2	2007	The results showed that the percentage of P-selectin in platelets without agonist stimulation was 10.6% in F3, 11.1% in F0 and 6.3% in C. After the addition of ADP/adrenaline, the percentages were 44%, 25.3% and 42%, respectively.	Epinephrine	164-174	selectin P	Homo sapiens	42-52
17170206-0	2007	Epinephrine enhances the sensitivity of rat vagal chemosensitive neurons: role of beta3-adrenoceptor.	Epinephrine	0-11	adrenoceptor beta 3	Rattus norvegicus	82-100
17170206-8	2007	This sensitizing effect of epinephrine is likely mediated through the activation of beta(3)-adrenoceptor and intracellular cAMP-PKA signaling cascade.	Epinephrine	27-38	adrenoceptor beta 3	Rattus norvegicus	84-104
17394461-10	2007	Nrf2 induction was specific to oxidative stress caused by catecholaminergic neurotransmitters as epinephrine also induced Nrf2, but the monoamine serotonin had no significant effect.	Epinephrine	97-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
17397728-1	2007	We describe a technique combining preoperative atropine sulfate 1% and intraoperative intracameral epinephrine in a 1:2500 dilution for the management of intraoperative floppy-iris syndrome (IFIS) induced by alpha(1A)-blocking agents such as tamsulosin.	Epinephrine	99-110	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	208-216
17259660-2	2007	Previous studies reported that in vivo administration of adrenaline and acute stress cause an increase in plasma LPL activity coinciding with a decrease in white adipose tissue (WAT) LPL activity.	Epinephrine	57-67	lipoprotein lipase	Rattus norvegicus	113-116
17259660-2	2007	Previous studies reported that in vivo administration of adrenaline and acute stress cause an increase in plasma LPL activity coinciding with a decrease in white adipose tissue (WAT) LPL activity.	Epinephrine	57-67	lipoprotein lipase	Rattus norvegicus	183-186
17394461-10	2007	Nrf2 induction was specific to oxidative stress caused by catecholaminergic neurotransmitters as epinephrine also induced Nrf2, but the monoamine serotonin had no significant effect.	Epinephrine	97-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-126
20409839-7	2007	In vitro studies indicate that renalase is a novel amine oxidase that specifically metabolizes circulating catecholamines including epinephrine and norepinephrine.	Epinephrine	132-143	renalase, FAD dependent amine oxidase	Homo sapiens	31-39
17405690-9	2007	Mercury, cadmium, and other heavy metals inactivate COMT, which increases serum and urinary epinephrine, norepinephrine, and dopamine.	Epinephrine	92-103	catechol-O-methyltransferase	Homo sapiens	52-56
17222943-1	2007	The vasoconstrictor neuropeptide Y (NPY) has been shown to down-regulate tyrosine hydroxylase expression in cultured adrenal chromaffin cells, which probably accounts for the higher plasma resting norepinephrine (NE) and epinephrine (E) concentrations observed in Y(1) knock-out mice (Y(1)-/-) than in wild-type mice (Y(1)+/+).	Epinephrine	200-211	neuropeptide Y	Mus musculus	20-34
17295024-0	2007	(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling.	Epinephrine	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	87-92
17295024-1	2007	Activation of either coexisting beta1- or beta2 -adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium.	Epinephrine	71-81	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	32-37
17295024-1	2007	Activation of either coexisting beta1- or beta2 -adrenoceptors with noradrenaline or adrenaline, respectively, causes maximum increases of contractility of human atrial myocardium.	Epinephrine	71-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	42-47
17295024-4	2007	It is unknown whether the endogenously occurring beta2 -adrenoceptor agonist adrenaline acts through the above cascade in human atrium and whether its mode of action could be changed in heart failure.	Epinephrine	77-87	adrenoceptor beta 2	Homo sapiens	49-68
17295024-5	2007	We assessed the effects of (-)-adrenaline, mediated through beta2 -adrenoceptors (in the presence of CGP 20712A 300 nM to block beta1 -adrenoceptors), on contractility and relaxation of right atrial trabecula obtained from nonfailing and failing human hearts.	Epinephrine	27-41	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	60-65
17295024-12	2007	The hastening of relaxation caused by (-)-adrenaline together with the PKA-catalyzed phosphorylation of the three proteins involved in relaxation, indicate coupling of beta2 -adrenoceptors to Gs protein.	Epinephrine	38-52	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	168-173
17295024-13	2007	The phosphorylation of phospholamban at serine16 and threonine17 evoked by (-)-adrenaline through beta2 -adrenoceptors and by (-)-noradrenaline through beta1 -adrenoceptors was not different in atria from nonfailing and failing hearts.	Epinephrine	75-89	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	98-103
17295024-15	2007	The positive inotropic and lusitropic potencies of (-)-adrenaline were conserved across Arg16Gly- and Gln27Glu-beta2 -adrenoceptor polymorphisms in the right atrium from patients undergoing coronary artery bypass surgery, chronically treated with beta1 -selective blockers.	Epinephrine	51-65	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	111-116
17295024-15	2007	The positive inotropic and lusitropic potencies of (-)-adrenaline were conserved across Arg16Gly- and Gln27Glu-beta2 -adrenoceptor polymorphisms in the right atrium from patients undergoing coronary artery bypass surgery, chronically treated with beta1 -selective blockers.	Epinephrine	51-65	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	247-252
17365862-0	2007	Epinephrine induces intracellular Ca2+ mobilization in thrombin-desensitized platelets: a role for GPIb-IX-V.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	55-63
17365862-1	2007	In this work we have investigated the ability of epinephrine to trigger the release of intracellular Ca2+ in thrombin-desensitized platelets.	Epinephrine	49-60	coagulation factor II, thrombin	Homo sapiens	109-117
17365862-3	2007	Although epinephrine alone had no effect on intracellular Ca2+ mobilization, its addition to thrombin-desensitized platelets was associated to a rapid and evident secondary release of intracellular Ca2+.	Epinephrine	9-20	coagulation factor II, thrombin	Homo sapiens	93-101
17196587-2	2007	Although the two lineages are closely related, only adrenergic chromaffin cells express phenylethanolamine N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine, while neurons and noradrenergic chromaffin cells are PNMT-negative.	Epinephrine	163-174	phenylethanolamine-N-methyltransferase	Mus musculus	88-126
17196587-2	2007	Although the two lineages are closely related, only adrenergic chromaffin cells express phenylethanolamine N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine, while neurons and noradrenergic chromaffin cells are PNMT-negative.	Epinephrine	163-174	phenylethanolamine-N-methyltransferase	Mus musculus	128-132
17365862-4	2007	This effect of epinephrine was not observed when platelets were desensitized with other agonists able to induce phospholipase C activation, including convulxin, U46619, and ADP.	Epinephrine	15-26	WD and tetratricopeptide repeats 1	Homo sapiens	173-176
17365862-6	2007	Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization.	Epinephrine	65-76	coagulation factor II, thrombin	Homo sapiens	23-31
17365862-6	2007	Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization.	Epinephrine	65-76	coagulation factor II, thrombin	Homo sapiens	129-137
17365862-6	2007	Addition of hirudin to thrombin-desensitized platelets prevented epinephrine-promoted secondary release of Ca2+, indicating that thrombin, rather than epinephrine itself, is actually responsible for this event as a consequence of thrombin receptors resensitization.	Epinephrine	65-76	coagulation factor II, thrombin	Homo sapiens	129-137
17365862-8	2007	Moreover, we found that thrombin was still able to induce a reduced, but evident release of Ca2+ from internal stores in PAR1- and PAR4-desensitized platelets, which could be followed by a secondary Ca2+ release upon subsequent addition of epinephrine.	Epinephrine	240-251	coagulation factor II, thrombin	Homo sapiens	24-32
17365862-8	2007	Moreover, we found that thrombin was still able to induce a reduced, but evident release of Ca2+ from internal stores in PAR1- and PAR4-desensitized platelets, which could be followed by a secondary Ca2+ release upon subsequent addition of epinephrine.	Epinephrine	240-251	coagulation factor II thrombin receptor	Homo sapiens	121-125
17365862-8	2007	Moreover, we found that thrombin was still able to induce a reduced, but evident release of Ca2+ from internal stores in PAR1- and PAR4-desensitized platelets, which could be followed by a secondary Ca2+ release upon subsequent addition of epinephrine.	Epinephrine	240-251	Prader Willi/Angelman region RNA 4	Homo sapiens	131-135
17365862-9	2007	Importantly, both the primary and the secondary Ca2+ release induced by thrombin and epinephrine in PAR1- and PAR4-desensitized platelets were abrogated upon cleavage of GPIbalpha by the metalloproteinase mocarhagin.	Epinephrine	85-96	coagulation factor II thrombin receptor	Homo sapiens	100-104
17365862-9	2007	Importantly, both the primary and the secondary Ca2+ release induced by thrombin and epinephrine in PAR1- and PAR4-desensitized platelets were abrogated upon cleavage of GPIbalpha by the metalloproteinase mocarhagin.	Epinephrine	85-96	Prader Willi/Angelman region RNA 4	Homo sapiens	110-114
17365862-9	2007	Importantly, both the primary and the secondary Ca2+ release induced by thrombin and epinephrine in PAR1- and PAR4-desensitized platelets were abrogated upon cleavage of GPIbalpha by the metalloproteinase mocarhagin.	Epinephrine	85-96	glycoprotein Ib platelet subunit alpha	Homo sapiens	170-179
17365862-10	2007	These results demonstrate a direct role of thrombin binding to GPIb-IX-V in the mobilization of Ca2+ from intracellular stores, and reveal that epinephrine can restore this process in desensitized platelets, thus prolonging the effect of thrombin stimulation.	Epinephrine	144-155	coagulation factor II, thrombin	Homo sapiens	238-246
17148458-7	2007	Activation of AKT by IGF-1 leads to neuroendocrine differentiation, and neuroendocrine differentiation induced by epinephrine requires AKT activation.	Epinephrine	114-125	AKT serine/threonine kinase 1	Homo sapiens	135-138
17127057-2	2007	L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM).	Epinephrine	0-12	carbonic anhydrase 1	Homo sapiens	54-58
17127057-2	2007	L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM).	Epinephrine	0-12	carbonic anhydrase 2	Homo sapiens	132-137
17127057-3	2007	Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of 36-63 microM.	Epinephrine	51-63	carbonic anhydrase 4	Homo sapiens	9-14
17207896-4	2007	The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture.	Epinephrine	108-119	neuropeptide Y	Mus musculus	70-73
17207896-4	2007	The aim of the present study was to determine the interaction between NPY and IL-1beta in catecholamine (norepinephrine, NE and epinephrine, EP) release from mouse chromaffin cells in culture.	Epinephrine	108-119	interleukin 1 beta	Mus musculus	78-86
17197851-7	2007	The animals of the milrinone-vasopressin group displayed significantly (P&lt;0.05) higher cardiac index values (30 min after return of spontaneous circulation: epinephrine, 65.8+/-13.2; vasopressin, 70.7+/-18.3; epinephrine-vasopressin, 69.1+/-36.2; milrinone-vasopressin, 120.7+/-34.8 ml.min.kg) without a decrease in mean arterial pressure or coronary perfusion pressure.	Epinephrine	160-171	vasopressin	Sus scrofa	29-40
17070556-9	2007	Urinary epinephrine levels correlated with AdipoR2 mRNA expression in liver tissues (r=-0.664, p&lt;0.05) in rats that exercised at a rate of 25 m/min for 30 min.	Epinephrine	8-19	adiponectin receptor 2	Rattus norvegicus	43-50
17376225-6	2007	Final end-tidal carbon dioxide values and average values of MAP in patients with restoration of pulse were significantly higher in the vasopressin/epinephrine group (p &lt; 0.01).	Epinephrine	147-158	arginine vasopressin	Homo sapiens	135-146
16934435-0	2007	GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3.	Epinephrine	44-54	glycogen synthase kinase 3 beta	Rattus norvegicus	0-9
16934435-3	2007	Surprisingly adrenaline alone increased phosphorylation of GSK-3beta Ser9 and GSK-3alpha Ser21 and adrenaline"s effects were additive with those of insulin but did not synergistically potentiate insulin action.	Epinephrine	13-23	glycogen synthase kinase 3 beta	Rattus norvegicus	59-68
16934435-3	2007	Surprisingly adrenaline alone increased phosphorylation of GSK-3beta Ser9 and GSK-3alpha Ser21 and adrenaline"s effects were additive with those of insulin but did not synergistically potentiate insulin action.	Epinephrine	13-23	glycogen synthase kinase 3 alpha	Rattus norvegicus	78-88
16934435-6	2007	The PKA inhibitor H89 (50 microM) reduced adrenaline-stimulated GSK-3beta Ser9 phosphorylation but did not influence the effects of insulin.	Epinephrine	42-52	glycogen synthase kinase 3 beta	Rattus norvegicus	64-73
17133078-4	2007	These systems allow bacteria to communicate across species boundaries, and the AI-3/epinephrine/norepinephrine system is involved in interkingdom signaling.	Epinephrine	84-95	family with sequence similarity 83 member H	Homo sapiens	79-83
17376225-13	2007	Resuscitated patients treated with vasopressin alone or followed by epinephrine have higher average and final end-tidal carbon dioxide values as well as a higher MAP on admission to the hospital than patients treated with epinephrine only.	Epinephrine	222-233	arginine vasopressin	Homo sapiens	35-46
17470271-8	2007	Plasma lactate, pyruvate, the lactate/pyruvate ratio, plasma glucose, and insulin doses were higher (p &lt; 0.05) in the adrenaline-treated patients than during milrinone or control conditions.	Epinephrine	121-131	insulin	Homo sapiens	74-81
17470271-10	2007	No between-group differences were observed in creatinine clearance, whereas plasma cystatin-C levels were significantly higher in the adrenaline than in the milrinone or the control group after 48 hours (p &lt; 0.05).	Epinephrine	134-144	cystatin C	Homo sapiens	83-93
17982884-8	2007	We also found that the activities and/or the levels of the mRNA and protein of aromatic L-amino acid decarboxylase (AADC, DOPA decarboxylase), DBH, phenylethanolamine N-methyltransferase (PNMT), which synthesize dopamine, noradrenaline, and adrenaline, respectively, were also decreased in PD brains, indicating that all catecholamine systems were widely impaired in PD brains.	Epinephrine	225-235	phenylethanolamine N-methyltransferase	Homo sapiens	148-186
17406961-5	2007	We have suggested that adrenaline, which also stimulates glucose metabolism through adrenoceptors, may act as the physiological substrate for GLUT4 recruitment.	Epinephrine	23-33	solute carrier family 2 member 4	Homo sapiens	142-147
17406961-7	2007	However, oxidation of adrenaline by MAO releases both H(2)O(2) and methylamine for further oxidation by SSAO.	Epinephrine	22-32	amine oxidase copper containing 2	Homo sapiens	104-108
17320309-5	2007	Recent findings indicate that diazepam exerts an inhibitory activity on different isoforms of the enzyme cyclic nucleotide phosphodiesterase, which can be found in the heart muscle and also show that diazepam potentate the positive inotropic effect of both noradrenaline and adrenaline, which subsequently leads to increase in myocardial contractility.	Epinephrine	260-270	phosphodiesterase 3B	Homo sapiens	105-140
17114981-0	2006	Simultaneous blockade of alpha1- and beta-actions of epinephrine during cardiopulmonary resuscitation.	Epinephrine	53-64	adrenoceptor alpha 1D	Homo sapiens	25-41
17365979-1	2007	PURPOSE: To elucidate differential functional and phenotypic changes in response to relevant catecholamines, the generation of oxidative free radicals by PMN, and changes in the expression of L-selectin and Mac-1 on the surface of PMN were examined in the presence of epinephrine, norepinephrine and dopamine in physiological and pharmacological concentrations.	Epinephrine	268-279	selectin L	Homo sapiens	192-202
17427275-7	2007	RESULTS: Plasma concentrations of epinephrine or dopamine prolong increased significantly 3 days after SAH, involved in elevation of plasma IL-10.	Epinephrine	34-45	interleukin 10	Homo sapiens	140-145
17427275-9	2007	Pre-treatment with epinephrine or dopamine inhibited LPS-stimulated IL-1beta production significantly in the PBMCs from the healthy volunteers.	Epinephrine	19-30	interleukin 1 beta	Homo sapiens	68-76
17054915-1	2006	Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons.	Epinephrine	168-178	tyrosine hydroxylase	Homo sapiens	0-20
17054915-1	2006	Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons.	Epinephrine	168-178	tyrosine hydroxylase	Homo sapiens	22-46
17075569-7	2006	The pK (D) values of the antagonists for adrenaline overflow correlated positively with pK(D) values at alpha(2C) binding sites (opossum kidney cells).	Epinephrine	41-51	adrenergic receptor, alpha 2c	Mus musculus	104-112
17114981-1	2006	OBJECTIVE: Experimental and clinical studies have implicated that alpha1- and beta-adrenergic effects of epinephrine significantly increased the severity of postresuscitation myocardial dysfunction by increasing myocardial oxygen consumption during ventricular fibrillation.	Epinephrine	105-116	adrenoceptor alpha 1D	Homo sapiens	66-72
17114981-2	2006	This prompted experimental studies to investigate the effect of simultaneous blockade of alpha1- and beta-actions of epinephrine during cardiopulmonary resuscitation.	Epinephrine	117-128	adrenoceptor alpha 1D	Homo sapiens	89-105
17114981-4	2006	RESULTS: Improved postresuscitation myocardial dysfunction was observed in epinephrine-treated animals after its alpha1- and beta-actions were blocked, which were associated with less postresuscitation arrhythmia, lower blood lactate level, better neurologic recovery, and longer duration of survival.	Epinephrine	75-86	adrenoceptor alpha 1D	Homo sapiens	113-129
17114981-5	2006	CONCLUSIONS: After simultaneous alpha1- and beta-adrenergic blockade, epinephrine administered during cardiopulmonary resuscitation yielded improved postresuscitation myocardial functions and significantly better postresuscitation outcomes.	Epinephrine	70-81	adrenoceptor alpha 1D	Homo sapiens	32-48
17079456-1	2006	Recent studies using ovarian cancer cells have shown that the catecholamine hormones norepinephrine (norepi) and epinephrine (epi) may influence cancer progression by modulating the expression of matrix metalloproteinases (MMP) and vascular endothelial growth factor (VEGF).	Epinephrine	88-99	vascular endothelial growth factor A	Homo sapiens	268-272
17356229-1	2006	Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline.	Epinephrine	119-129	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
17356229-1	2006	Phenylethanolamine N-methyltransferase (PNMT) is a final enzyme in catecholamine synthesizing cascade that converts noradrenaline to adrenaline.	Epinephrine	119-129	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
16888042-10	2006	The ratio of nocturnal urinary epinephrine to beta(2)-AR density suggested a decreased beta(2)-AR sensitivity for the OT group (2.4-fold increase).	Epinephrine	31-42	adrenoceptor beta 2	Homo sapiens	87-97
17134621-1	2006	Vasopressin administration has been suggested during cardiopulmonary resuscitation, and a previous clinical trial has suggested that vasopressin is most effective when administered with epinephrine.	Epinephrine	186-197	arginine vasopressin	Homo sapiens	133-144
16950829-9	2006	Identification of the enzymes as tyrosinases was confirmed by the ability of lichen thalli or leachates derived by shaking lichens in distilled water to metabolize substrates such as L-dihydroxyphenylalanine (DOPA), tyrosine and epinephrine readily in the absence of hydrogen peroxide, the sensitivity of the enzymes to the inhibitors cyanide, azide and hexylresorcinol, activation by SDS and having typical tyrosinase molecular masses of approx.	Epinephrine	229-240	tyrosinase	Homo sapiens	33-43
17082723-9	2006	The MBP-by-epinephrine AUC interaction predicted FVII:C AUC (beta = 0.28) and fibrinogen AUC (beta = -0.30), and the MBP-by-norepinephrine AUC interaction predicted FVIII:C AUC (beta = -0.28), all with borderline significance (Ps &lt; 0.09) and independent of age and BMI.	Epinephrine	11-22	fibrinogen beta chain	Homo sapiens	78-88
17134621-0	2006	Usefulness of vasopressin administered with epinephrine during out-of-hospital cardiac arrest.	Epinephrine	44-55	arginine vasopressin	Homo sapiens	14-25
16470514-1	2006	The enzyme catechol-O-methyltransferase (COMT) plays an important role in the metabolism of catechol estrogens and degradation of the catecholamine neurotransmitters, such as epinephrine.	Epinephrine	175-186	catechol-O-methyltransferase	Homo sapiens	11-39
17053072-1	2006	During the fight-or-flight response, epinephrine and norepinephrine released by the sympathetic nervous system increase L-type calcium currents conducted by Ca(V)1.2a channels in the heart, which contributes to enhanced cardiac performance.	Epinephrine	37-48	caveolin 1	Rattus norvegicus	157-163
16887279-8	2006	In summary, our results indicate that the beta-endorphinergic system may play a part in the compensatory response to sodium overload, since the absence of beta-endorphin causes an increase in systolic blood pressure, and increases median preoptic nucleus neural activity and urinary epinephrine excretion.	Epinephrine	283-294	pro-opiomelanocortin-alpha	Mus musculus	42-56
16690773-1	2006	Skeletal muscle hormone-sensitive lipase (HSL) activity is increased by contractions and increases in blood epinephrine (EPI) concentrations and cyclic AMP activation of the adrenergic pathway during prolonged exercise.	Epinephrine	108-119	lipase E, hormone sensitive type	Homo sapiens	16-40
16690773-1	2006	Skeletal muscle hormone-sensitive lipase (HSL) activity is increased by contractions and increases in blood epinephrine (EPI) concentrations and cyclic AMP activation of the adrenergic pathway during prolonged exercise.	Epinephrine	108-119	lipase E, hormone sensitive type	Homo sapiens	42-45
16962127-1	2006	Epinephrine QT stress testing is an effective diagnostic tool to unmask concealed Long QT Syndrome (LQTS), particularly type 1 LQTS (LQT1).	Epinephrine	0-11	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	133-137
17051993-10	2006	Epinephrine at 0.005-0.02 microg x kg(-1) x min(-1) was infused continuously to maintain his blood pressure.	Epinephrine	0-11	CD59 molecule (CD59 blood group)	Homo sapiens	44-50
16854373-1	2006	alpha2A adrenergic receptor (ADRA2A) on platelets interacts with epinephrine, which has a key role in regulating platelet functions.	Epinephrine	65-76	adrenoceptor alpha 2A	Homo sapiens	0-27
16854373-1	2006	alpha2A adrenergic receptor (ADRA2A) on platelets interacts with epinephrine, which has a key role in regulating platelet functions.	Epinephrine	65-76	adrenoceptor alpha 2A	Homo sapiens	29-35
16905768-0	2006	Decrease in intramuscular lipid droplets and translocation of HSL in response to muscle contraction and epinephrine.	Epinephrine	104-115	lipase E, hormone sensitive type	Rattus norvegicus	62-65
16905768-11	2006	Finally, we demonstrate HSL translocation to IMTG and ADRP after stimulation with epinephrine or contraction.	Epinephrine	82-93	lipase E, hormone sensitive type	Rattus norvegicus	24-27
16905768-11	2006	Finally, we demonstrate HSL translocation to IMTG and ADRP after stimulation with epinephrine or contraction.	Epinephrine	82-93	perilipin 2	Rattus norvegicus	54-58
16919292-7	2006	There was no change in field potential properties, but dephosphorylated connexin 43 (Cx43) was increased 60+/-16% with the combination as compared to epinephrine alone (P&lt;0.05).	Epinephrine	150-161	gap junction protein, alpha 1	Rattus norvegicus	85-89
16919292-8	2006	Treatment with okadaic acid, a phosphatase inhibitor, prevented the Cx43 dephosphorylation and the reduction in conduction velocity upon exposure to halon and epinephrine.	Epinephrine	159-170	gap junction protein, alpha 1	Rattus norvegicus	68-72
16931995-6	2006	During cardiopulmonary resuscitation, a 40-U bolus dose of vasopressin may be considered to replace the first or second bolus of epinephrine regardless of the initial rhythm.	Epinephrine	129-140	arginine vasopressin	Homo sapiens	59-70
16470514-1	2006	The enzyme catechol-O-methyltransferase (COMT) plays an important role in the metabolism of catechol estrogens and degradation of the catecholamine neurotransmitters, such as epinephrine.	Epinephrine	175-186	catechol-O-methyltransferase	Homo sapiens	41-45
16685530-7	2006	These cells appear more mature than the scattered intracortical chromaffin progenitors and express the adrenaline synthesizing enzyme PNMT with a delay of 1 day in comparison with wildtype littermates.	Epinephrine	103-113	phenylethanolamine-N-methyltransferase	Mus musculus	134-138
16634720-2	2006	Since hypotension increases adrenaline levels and adrenaline can produce skeletal muscle vasodilatation by activating beta2 receptors, adrenaline might induce a positive feedback loop precipitating circulatory collapse.	Epinephrine	50-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	118-123
16634720-2	2006	Since hypotension increases adrenaline levels and adrenaline can produce skeletal muscle vasodilatation by activating beta2 receptors, adrenaline might induce a positive feedback loop precipitating circulatory collapse.	Epinephrine	50-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	118-123
16643958-2	2006	Phenylethanolamine-N-methyltransferase, the enzyme catalyzing the conversion of norepinephrine into epinephrine, was not detected in either Mk -/- and WT (+/+) mouse aorta.	Epinephrine	83-94	phenylethanolamine-N-methyltransferase	Mus musculus	0-38
16907658-10	2006	Recently, subcutaneous adrenaline has also been utilised as an alternative approach to manage HSR to oxaliplatin.	Epinephrine	23-33	HSR	Homo sapiens	94-97
16915013-7	2006	The potential contribution of reactive oxygen species to the prohypertensive and proatherosclerotic effects of RAS is supported by evidence that nicotinamide adenine dinucleotide phosphate, reduced form oxidase is specifically stimulated by angiotensin II, an activity not shared by epinephrine.	Epinephrine	283-294	angiotensinogen	Homo sapiens	241-255
16961612-6	2006	We studied candidate genes relevant to epinephrine-mediated platelet activation and found that hyperreactivity to epinephrine was associated with a polymorphism on the gene (GNB3) encoding the beta-3 subunit of G proteins (P = 0.03).	Epinephrine	39-50	G protein subunit beta 3	Homo sapiens	174-178
16961612-6	2006	We studied candidate genes relevant to epinephrine-mediated platelet activation and found that hyperreactivity to epinephrine was associated with a polymorphism on the gene (GNB3) encoding the beta-3 subunit of G proteins (P = 0.03).	Epinephrine	114-125	G protein subunit beta 3	Homo sapiens	174-178
17102092-1	2006	Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not.	Epinephrine	163-174	phenylethanolamine N-methyltransferase	Homo sapiens	73-111
16873551-4	2006	Ventricular tachycardia (VT) was observed after caffeine and epinephrine injection in RyR2(R176Q/+), but not in WT, mice.	Epinephrine	61-72	ryanodine receptor 2, cardiac	Mus musculus	86-90
17102092-1	2006	Pheochromocytomas in multiple endocrine neoplasia type 2 (MEN-2) express phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes conversion of norepinephrine to epinephrine, whereas those in von Hippel-Lindau (VHL) syndrome do not.	Epinephrine	163-174	phenylethanolamine N-methyltransferase	Homo sapiens	113-117
17102093-8	2006	The level of SDH mRNAs expression also correlated with the expression of phenylethanolamine N-methyl transferase (PNMT), an adrenaline synthesizing enzyme (P&lt;0.01), which may explain the correlation between SDH expression and adrenaline content (P&lt;0.05).	Epinephrine	124-134	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	13-16
17102093-8	2006	The level of SDH mRNAs expression also correlated with the expression of phenylethanolamine N-methyl transferase (PNMT), an adrenaline synthesizing enzyme (P&lt;0.01), which may explain the correlation between SDH expression and adrenaline content (P&lt;0.05).	Epinephrine	124-134	phenylethanolamine N-methyltransferase	Homo sapiens	73-112
17102093-8	2006	The level of SDH mRNAs expression also correlated with the expression of phenylethanolamine N-methyl transferase (PNMT), an adrenaline synthesizing enzyme (P&lt;0.01), which may explain the correlation between SDH expression and adrenaline content (P&lt;0.05).	Epinephrine	124-134	phenylethanolamine N-methyltransferase	Homo sapiens	114-118
16556729-8	2006	However, the excretion of epinephrine, norepinephrine, and dopamine was significantly elevated in the Chga null mutants.	Epinephrine	26-37	chromogranin A	Mus musculus	102-106
16730120-3	2006	Following pretreatment with the MEK1 inhibitor PD98059, the NF-kappaB response to epinephrine becomes uniform with loss of subtype specificity.	Epinephrine	82-93	mitogen activated protein kinase kinase 1	Rattus norvegicus	32-36
16714291-9	2006	Here we report that the mechanism for the beta-AR antagonist-mediated augmentation of wound repair is due to beta2-AR blockade, preventing the binding of endogenously synthesized epinephrine.	Epinephrine	179-190	adrenoceptor beta 2	Homo sapiens	109-117
16765344-11	2006	These results suggest that centrally administered histamine evokes plasma noradrenaline and adrenaline from adrenal medulla by brain cyclooxygenase-1- and thromboxane A(2)-mediated mechanisms in rats.	Epinephrine	77-87	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	133-149
16611835-2	2006	In the present study, we show that NA, dopamine, and adrenaline all directly hyperpolarized orexin neurons.	Epinephrine	53-63	hypocretin	Mus musculus	92-98
16645894-8	2006	Epinephrine is regulated in part through its biosynthesis catalyzed by the final enzyme in the catecholamine pathway, phenylethanolamine N-methyltransferase (E.C.	Epinephrine	0-11	phenylethanolamine N-methyltransferase	Homo sapiens	118-156
16645894-12	2006	The pioneering work of Julius Axelrod forged the path to our present understanding of how the stress hormone and neurotransmitter epinephrine, is regulated, in particular via its biosynthesis by PNMT.	Epinephrine	130-141	phenylethanolamine N-methyltransferase	Homo sapiens	195-199
16995444-3	2006	For example, occupancy of central micro- and delta-OR and also ORL1 receptors increases cardiac tolerance to arrhythmogenic action epinephrine and aconitine.	Epinephrine	131-142	opioid related nociceptin receptor 1	Rattus norvegicus	63-67
16432541-3	2006	RESULTS: A moderate expression of transgenic resistin in adipose tissue was associated with significant increase in the FFA/glycerol ratio during adrenaline-stimulated lipolysis in the SHR-Resistin transgenic rats (3.27+/-0.26) compared to SHR controls (2.11+/-0.10, P=0.0005).	Epinephrine	146-156	resistin	Rattus norvegicus	45-53
16449297-6	2006	CRH KO glucose requirements were significantly higher during day 1 hypoglycemia despite epinephrine and glucagon responses that were comparable to or greater than those in WT.	Epinephrine	88-99	corticotropin releasing hormone	Mus musculus	0-3
16449297-10	2006	However, Prior Hypo CRH KO mice had significantly lower day 2 epinephrine and norepinephrine vs.	Epinephrine	62-73	corticotropin releasing hormone	Mus musculus	20-23
16740441-5	2006	S100B secretion in dissociated epididymal fat cells was investigated in the presence of epinephrine.	Epinephrine	88-99	S100 calcium binding protein B	Rattus norvegicus	0-5
16740441-7	2006	Moreover, we demonstrated in vitro epinephrine stimulated S100B release from fat cells.	Epinephrine	35-46	S100 calcium binding protein B	Rattus norvegicus	58-63
16788312-9	2006	Furthermore, platelets adhering to albumin after adrenaline and LPA treatment expressed P-selectin.	Epinephrine	49-59	selectin P	Homo sapiens	88-98
16774125-2	2006	However, N-type Ca2+ channel alpha1B-deficient mice with a CBA/JN background show normal plasma norepinephrine and epinephrine levels, presumably owing to compensation by other gene(s).	Epinephrine	99-110	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	29-36
16839358-1	2006	OBJECTIVE: von Willebrand factor (VWF) is acutely released from endothelial cells in response to numerous calcium-raising agents (e.g. thrombin, histamine) and cAMP-raising agents (e.g. epinephrine, adenosine, vasopressin).	Epinephrine	186-197	von Willebrand factor	Homo sapiens	11-32
16839358-1	2006	OBJECTIVE: von Willebrand factor (VWF) is acutely released from endothelial cells in response to numerous calcium-raising agents (e.g. thrombin, histamine) and cAMP-raising agents (e.g. epinephrine, adenosine, vasopressin).	Epinephrine	186-197	von Willebrand factor	Homo sapiens	34-37
16644734-1	2006	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Epinephrine	109-119	tyrosine hydroxylase	Homo sapiens	0-20
16644734-1	2006	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of the catecholamines dopamine, noradrenaline, and adrenaline.	Epinephrine	109-119	tyrosine hydroxylase	Homo sapiens	22-24
16696852-1	2006	Phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is the terminal enzyme of the catecholaminergic pathway converting noradrenaline to adrenaline.	Epinephrine	129-139	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
16546349-12	2006	The present results show that overexpression of galanin under the control of the DBH promoter does not only occur, as expected in these mice, in noradrenline/adrenaline neurons but also in DRG neurons, particularly in large and medium-sized NPs.	Epinephrine	158-168	galanin and GMAP prepropeptide	Mus musculus	48-55
16546349-12	2006	The present results show that overexpression of galanin under the control of the DBH promoter does not only occur, as expected in these mice, in noradrenline/adrenaline neurons but also in DRG neurons, particularly in large and medium-sized NPs.	Epinephrine	158-168	dopamine beta hydroxylase	Mus musculus	81-84
16696852-1	2006	Phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is the terminal enzyme of the catecholaminergic pathway converting noradrenaline to adrenaline.	Epinephrine	129-139	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
16563597-6	2006	After 2 min of CPR, epinephrine (adrenaline) (0.	Epinephrine	20-31	cytochrome p450 oxidoreductase	Homo sapiens	15-18
17176640-0	2006	A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1.	Epinephrine	66-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	109-114
16717120-15	2006	Patients in the epinephrine group also had higher glycemia (first 24 hours) and needed insulin therapy more often.	Epinephrine	16-27	insulin	Homo sapiens	87-94
16581093-5	2006	After normalization with MPP+ uptake, OCT2 and OCT3 subtypes share a similar monoamine preference profile, with higher transport efficacies for epinephrine and histamine than for the other monoamines.	Epinephrine	144-155	solute carrier family 22 member 2	Rattus norvegicus	38-42
16581093-5	2006	After normalization with MPP+ uptake, OCT2 and OCT3 subtypes share a similar monoamine preference profile, with higher transport efficacies for epinephrine and histamine than for the other monoamines.	Epinephrine	144-155	solute carrier family 22 member 8	Rattus norvegicus	47-51
16581093-6	2006	Interestingly, a significant level of epinephrine transport, previously only shown for rOCT2, is achieved by most OCTs subtypes.	Epinephrine	38-49	solute carrier family 22 member 2	Rattus norvegicus	87-92
16098714-1	2006	Previous study carried out on PC12 cells expressing each alpha(2)-adrenergic receptor subtype individually (PC12/alpha(2A), /alpha(2B) or /alpha(2C)) have shown that epinephrine causes activation of PI3K and phosphorylation of Erk 1/2.	Epinephrine	166-177	mitogen activated protein kinase 3	Rattus norvegicus	227-234
16580633-1	2006	The beta(2) adrenergic receptor (beta(2)AR) is a G protein-coupled receptor that is selective to epinephrine.	Epinephrine	97-108	adrenoceptor beta 2	Homo sapiens	4-31
16580633-1	2006	The beta(2) adrenergic receptor (beta(2)AR) is a G protein-coupled receptor that is selective to epinephrine.	Epinephrine	97-108	adrenoceptor beta 2	Homo sapiens	33-42
16651733-5	2006	Epinephrine was found to increase expression of AQP3, although glucagon showed no change of expression.	Epinephrine	0-11	aquaporin 3 (Gill blood group)	Homo sapiens	48-52
16098714-5	2006	The effects of epinephrine on MAPK and Akt were mimicked by cell exposure to exogenous AA.	Epinephrine	15-26	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
16098714-7	2006	Treatment with 1,10-phenanthroline, CRM197, or tyrphostin AG1478 suppressed MAPK and Akt phosphorylation by epinephrine or AA, in a subtype-specific manner.	Epinephrine	108-119	AKT serine/threonine kinase 1	Rattus norvegicus	85-88
16098714-8	2006	Furthermore, conditioned culture medium from epinephrine-treated PC12/alpha(2) induced MAPK and Akt phosphorylation in wild-type PC12.	Epinephrine	45-56	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
16098714-3	2006	In all three clones, epinephrine-induced phosphorylation of MAPK or Akt was abolished by prior treatment with ketoconazole, but not with indomethacin or nordihydroguaiaretic acid.	Epinephrine	21-32	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
16269576-8	2006	Urinary norepinephrine and epinephrine excretion was higher in RGS2(-/-) than in RGS2(+/+) mice.	Epinephrine	11-22	regulator of G-protein signaling 2	Mus musculus	63-67
24678094-20	2006	Platelet aggregation to epinephrine 0.1 mM was inhibited with Omega3FA+Poli and Omega3FA+Pla (34.8% and 20.1%; both, P &lt; 0.001), with similar results for both groups.	Epinephrine	24-35	DNA polymerase iota	Homo sapiens	71-75
15896888-7	2006	An adrenaline pen is provided for use in case of anaphylaxis.	Epinephrine	3-13	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	14-17
16552222-5	2006	Arginine vasopressin has been shown to be as effective as epinephrine in patients with ventricular fibrillation and pulseless electrical activity, and may be more effective in patients presenting with asystole or as the second vasopressor (after epinephrine) in refractory cardiac arrest.	Epinephrine	246-257	arginine vasopressin	Homo sapiens	9-20
16552222-10	2006	Arginine vasopressin may be considered in patients presenting with asystole or who are unresponsive to initial treatment with epinephrine.	Epinephrine	126-137	arginine vasopressin	Homo sapiens	9-20
16567530-4	2006	Here we show that glucose-induced activation of ERK1/2 is inhibited by epinephrine through the alpha2-adrenergic receptor.	Epinephrine	71-82	mitogen-activated protein kinase 3	Homo sapiens	48-54
16567530-5	2006	Epinephrine and the selective alpha2-adrenergic agonist UK14304 reduced insulin secretion and glucose-stimulated ERK1/2 activation in a pertussis toxin-sensitive manner, implicating the alpha subunit of a Gi family member.	Epinephrine	0-11	mitogen-activated protein kinase 3	Homo sapiens	113-119
16551744-3	2006	Here we include explicit H(2)O and an infinite lipid bilayer membrane in molecular dynamics (MD) simulations of three systems: apo-beta2AR, epinephrine-bound beta2AR, and butoxamine-bound beta2AR (epinephrine is an endogenous agonist, and butoxamine is a beta2AR selective antagonist).	Epinephrine	140-151	adrenoceptor beta 2	Homo sapiens	158-165
16396986-2	2006	The blunted epinephrine responses are associated with reduced adrenomedullary tyrosine hydroxylase (TH) mRNA levels.	Epinephrine	12-23	tyrosine hydroxylase	Rattus norvegicus	78-98
16396986-2	2006	The blunted epinephrine responses are associated with reduced adrenomedullary tyrosine hydroxylase (TH) mRNA levels.	Epinephrine	12-23	tyrosine hydroxylase	Rattus norvegicus	100-102
16551744-3	2006	Here we include explicit H(2)O and an infinite lipid bilayer membrane in molecular dynamics (MD) simulations of three systems: apo-beta2AR, epinephrine-bound beta2AR, and butoxamine-bound beta2AR (epinephrine is an endogenous agonist, and butoxamine is a beta2AR selective antagonist).	Epinephrine	140-151	adrenoceptor beta 2	Homo sapiens	158-165
16551744-3	2006	Here we include explicit H(2)O and an infinite lipid bilayer membrane in molecular dynamics (MD) simulations of three systems: apo-beta2AR, epinephrine-bound beta2AR, and butoxamine-bound beta2AR (epinephrine is an endogenous agonist, and butoxamine is a beta2AR selective antagonist).	Epinephrine	140-151	adrenoceptor beta 2	Homo sapiens	158-165
16534005-1	2006	BACKGROUND: A paradoxical increase in the uncorrected QT interval during infusion of low-dose epinephrine appears pathognomonic for type 1 long-QT syndrome (LQT1).	Epinephrine	94-105	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	157-161
16534005-8	2006	The median change in QT interval during low-dose epinephrine infusion was -23 ms in the gene-negative group, 78 ms in LQT1, -4 ms in LQT2, and -58 ms in LQT3.	Epinephrine	49-60	potassium voltage-gated channel subfamily H member 2	Homo sapiens	133-137
16534005-8	2006	The median change in QT interval during low-dose epinephrine infusion was -23 ms in the gene-negative group, 78 ms in LQT1, -4 ms in LQT2, and -58 ms in LQT3.	Epinephrine	49-60	sodium voltage-gated channel alpha subunit 5	Homo sapiens	153-157
16188906-9	2006	AMPK inhibited epinephrine-induced HSL activity in L6 myotubes and was associated with reduced HSL Ser(660) but not Ser(563) phosphorylation.	Epinephrine	15-26	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-4
16424367-10	2006	This demonstrates a neurogenic component in the maintenance of this phenotype, which is further supported by an increase of urinary norepinephrine and epinephrine excretion in Kcc3(-/-) mice.	Epinephrine	135-146	solute carrier family 12, member 6	Mus musculus	176-180
16188906-9	2006	AMPK inhibited epinephrine-induced HSL activity in L6 myotubes and was associated with reduced HSL Ser(660) but not Ser(563) phosphorylation.	Epinephrine	15-26	lipase E, hormone sensitive type	Homo sapiens	35-38
16188906-9	2006	AMPK inhibited epinephrine-induced HSL activity in L6 myotubes and was associated with reduced HSL Ser(660) but not Ser(563) phosphorylation.	Epinephrine	15-26	lipase E, hormone sensitive type	Homo sapiens	95-98
16188906-11	2006	Conversely, in 3T3-L1 adipocytes, AMPK activation after epinephrine stimulation did not prevent HSL activity or glycerol release, which coincided with maintenance of HSL Ser(660) phosphorylation.	Epinephrine	56-67	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	34-38
16542483-3	2006	A subgroup analysis of a large prospective CPR investigation and of retrospective CPR studies suggests that vasopressin may be especially beneficial when combined with epinephrine.	Epinephrine	168-179	arginine vasopressin	Homo sapiens	108-119
16423344-0	2006	[35S]GTPgammaS binding at the human dopamine D4 receptor variants hD4.2, hD4.4 and hD4.7 following stimulation by dopamine, epinephrine and norepinephrine.	Epinephrine	124-135	dopamine receptor D4	Homo sapiens	36-56
16423344-8	2006	Agonism of norepinephrine and epinephrine at the dopamine D4 receptor may indicate an important way of cross-reactivity among the different monoamine neurotransmitter systems.	Epinephrine	14-25	dopamine receptor D4	Homo sapiens	49-69
16505652-9	2006	Glibenclamide (10 M) and CFTRinh-172 (10 M), cystic fibrosis transmembrane conductance regulator inhibitors, completely inhibited the epinephrine-induced stimulation of alveolar fluid clearance.	Epinephrine	134-145	CF transmembrane conductance regulator	Homo sapiens	45-96
16408233-1	2006	Proenkephalin peptide F [107-140] is an enkephalin-containing peptide found predominantly within the adrenal medulla and is co-packaged with epinephrine within adrenal medullary chromaffin granules.	Epinephrine	141-152	proenkephalin	Homo sapiens	0-13
16420577-7	2006	Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine.	Epinephrine	255-266	coagulation factor II thrombin receptor	Homo sapiens	92-121
16303838-8	2006	RESULTS: Plasma epinephrine increased 10-fold and plasma norepinephrine 2-fold in response to insulin-induced hypoglycemia.	Epinephrine	16-27	insulin	Homo sapiens	94-101
16420577-7	2006	Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine.	Epinephrine	255-266	coagulation factor II thrombin receptor	Homo sapiens	123-127
16420577-7	2006	Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine.	Epinephrine	255-266	coagulation factor II, thrombin	Homo sapiens	72-80
16420577-7	2006	Dose-response curves for peptide agonists specific for the two platelet thrombin receptors, protease-activated receptor 1 (PAR1) and PAR4, show a relative responsiveness that mirrors that of human platelets, and sub-maximal ADP responses are augmented by epinephrine.	Epinephrine	255-266	F2R like thrombin or trypsin receptor 3	Homo sapiens	133-137
16091956-5	2006	The anti-proteolytic effect of CL or epinephrine was partially prevented by 10(-5) M SR 59230A, a selective beta3-adrenoceptor antagonist.	Epinephrine	37-48	adrenoceptor beta 3	Rattus norvegicus	108-126
16648777-1	2006	OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline.	Epinephrine	105-115	catechol-O-methyltransferase	Homo sapiens	16-44
16648777-1	2006	OBJECTIVES: The catechol-O-methyltransferase (COMT) is an enzyme involved in the metabolism of dopamine, adrenaline and noradrenaline.	Epinephrine	105-115	catechol-O-methyltransferase	Homo sapiens	46-50
16185832-4	2006	Results showed that ALE concentration dependently increased HO-1 protein and enzyme activity, and protected cells from H(2)O(2)-induced cytotoxicity, with an IC(50) of 0.526 mg/ml.	Epinephrine	20-23	heme oxygenase 1	Mus musculus	60-64
16185832-7	2006	The expression of HO-1 protein by ALE was reduced by pretreatment with LY83583 and ODQ, specific inhibitors of guanylate cyclase, but not by PKA inhibitors, H89 and KT5720, indicating that PKG signaling pathway regulates HO-1 induction by ALE.	Epinephrine	34-37	heme oxygenase 1	Mus musculus	18-22
16185832-7	2006	The expression of HO-1 protein by ALE was reduced by pretreatment with LY83583 and ODQ, specific inhibitors of guanylate cyclase, but not by PKA inhibitors, H89 and KT5720, indicating that PKG signaling pathway regulates HO-1 induction by ALE.	Epinephrine	34-37	heme oxygenase 1	Mus musculus	221-225
16185832-8	2006	Taken together, it is concluded that PKG-dependent HO-1 induction is one of the important antioxidant mechanisms by which ALE protects RAW264.7 cells from H(2)O(2).	Epinephrine	122-125	heme oxygenase 1	Mus musculus	51-55
16377004-6	2006	We also used corticoliberin (CRH) knockout mice, where secretion of adrenaline is significantly suppressed.	Epinephrine	68-78	corticotropin releasing hormone	Mus musculus	13-27
16889669-6	2006	Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine.	Epinephrine	164-175	interleukin 10	Homo sapiens	68-73
16889669-6	2006	Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine.	Epinephrine	164-175	interferon gamma	Homo sapiens	119-128
16889669-8	2006	A reduced IL-4 production upon co-incubation with 10(-5) M epinephrine was observed in RA patients only.	Epinephrine	59-70	interleukin 4	Homo sapiens	10-14
16451161-14	2006	DISCUSSION: ACE inhibitor-provoked angioedema shares many clinical features with hereditary angioedema (HAE), including a limited effect of steroids, antihistamines and epinephrine.	Epinephrine	169-180	angiotensin I converting enzyme	Homo sapiens	12-15
16889669-6	2006	Catecholamines inhibited the synthesis of IFN-gamma, TNF-alpha, and IL-10 at a concentration of 10(-5) M. In addition, IFN-gamma release was suppressed by 10(-7) M epinephrine.	Epinephrine	164-175	interferon gamma	Homo sapiens	42-51
16377004-6	2006	We also used corticoliberin (CRH) knockout mice, where secretion of adrenaline is significantly suppressed.	Epinephrine	68-78	corticotropin releasing hormone	Mus musculus	29-32
16225854-2	2006	METHODS: The positive inotropic effects of noradrenaline (in the presence of the beta2-selective antagonist ICI118551) and adrenaline (in the presence of the beta1-selective antagonist CGP20712), mediated through beta1- and beta2-adrenoceptors, respectively, were investigated in atrial and ventricular trabeculae.	Epinephrine	46-56	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	213-218
16225854-4	2006	RESULTS: Carvedilol was a 13-fold more potent competitive antagonist of the effects of adrenaline at beta2-adrenoceptors (-logKB=10.13+/-0.08) than of noradrenaline at beta1-adrenoceptors (-logKB=9.02+/-0.07) in human right atrium.	Epinephrine	87-97	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	101-106
16225854-4	2006	RESULTS: Carvedilol was a 13-fold more potent competitive antagonist of the effects of adrenaline at beta2-adrenoceptors (-logKB=10.13+/-0.08) than of noradrenaline at beta1-adrenoceptors (-logKB=9.02+/-0.07) in human right atrium.	Epinephrine	87-97	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	168-173
16102757-6	2006	The affinity of the beta2-adrenoceptor for isoprenaline and adrenaline (beta2-values of 8.3 and 7.9) was clearly higher than for noradrenaline (beta2-value of 6.5).	Epinephrine	60-70	beta-2 adrenergic receptor	Oncorhynchus mykiss	20-38
16902291-2	2006	The undesired fat deposits are injected with tumescence fluid containing saline, epinephrine, bicarbonate and lidocaine; the latter is used as the only source of pain control.	Epinephrine	81-92	FAT atypical cadherin 1	Homo sapiens	14-17
16424800-3	2006	Therefore, we quantified the hemodynamic response to infusion of adrenaline (0.04, 0.06, and 0.08 microg x kg(-1) x min(-1) for 20 minutes each) in 8 healthy men and 8 healthy premenopausal women.	Epinephrine	65-75	CD59 molecule (CD59 blood group)	Homo sapiens	116-122
16722229-3	2006	Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux.	Epinephrine	18-29	solute carrier family 6 member 3	Homo sapiens	67-70
16722229-3	2006	Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux.	Epinephrine	18-29	solute carrier family 6 member 4	Homo sapiens	77-86
16722229-3	2006	Cotransport in norepinephrine (NET), epinephrine (EpiT), dopamine (DAT), and serotonin (SERT) transporters couples downhill Na+ flux to uphill transmitter flux.	Epinephrine	18-29	solute carrier family 6 member 4	Homo sapiens	88-92
16722235-11	2006	The TEs of OCT1 and OCT2 for dopamine, noradrenaline, adrenaline and 5-HT in general are rather low, in the range relative to MPP+ of 5%-15%.	Epinephrine	42-52	solute carrier family 22 member 1	Rattus norvegicus	11-15
16722235-11	2006	The TEs of OCT1 and OCT2 for dopamine, noradrenaline, adrenaline and 5-HT in general are rather low, in the range relative to MPP+ of 5%-15%.	Epinephrine	42-52	POU class 2 homeobox 2	Rattus norvegicus	20-24
16426068-0	2006	A two model receptor system of the alpha1D adrenergic receptor to describe interactions with epinephrine and BMY7378.	Epinephrine	93-104	adrenoceptor alpha 1D	Homo sapiens	35-62
16192313-6	2006	Brain catecholamine analyses indicated that ketamine decreased hippocampus epinephrine levels in C3H/HeHsd but elevated hippocampus epinephrine levels in FVB/Hsd, suggesting one potential mechanism for AEP vulnerability to ketamine.	Epinephrine	75-86	histidine ammonia lyase	Mus musculus	103-106
16719987-6	2006	Acetylcholine and epinephrine contribute with IL-10 and other mediators to the anti-inflammatory compensatory response initiated to dampen the inflammatory process.	Epinephrine	18-29	interleukin 10	Homo sapiens	46-51
16735096-5	2006	These causative factors bring about increasing amounts of toxins and radicals which impair the ATP generation in the CNS so that through the announcement of a non-existing hypoglycaemia the release of the insulin antagonists hGH, cortisol and adrenaline is induced.	Epinephrine	243-253	insulin	Homo sapiens	205-212
16219387-1	2005	Multiple intracellular and extracellular regulatory factors affect transcription of the tyrosine hydroxylase (TH) gene encoding the rate-limiting enzyme in the biosynthesis of the neurotransmitters dopamine, norepinephrine and epinephrine.	Epinephrine	211-222	tyrosine hydroxylase	Homo sapiens	88-108
16363801-0	2005	Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.	Epinephrine	53-63	phenylethanolamine N-methyltransferase	Homo sapiens	84-122
16878403-1	2006	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Epinephrine	91-102	catechol-O-methyltransferase	Homo sapiens	0-28
16878403-1	2006	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Epinephrine	91-102	catechol-O-methyltransferase	Homo sapiens	30-34
16219387-1	2005	Multiple intracellular and extracellular regulatory factors affect transcription of the tyrosine hydroxylase (TH) gene encoding the rate-limiting enzyme in the biosynthesis of the neurotransmitters dopamine, norepinephrine and epinephrine.	Epinephrine	211-222	tyrosine hydroxylase	Homo sapiens	110-112
15908181-0	2005	Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.	Epinephrine	0-10	AKT serine/threonine kinase 1	Homo sapiens	42-45
16400891-1	2005	BACKGROUND: Many health care professionals believe that a nonprescription epinephrine metered-dose inhaler is less effective and shorter acting and has more cardiovascular adverse effects than prescription beta2-agonists.	Epinephrine	74-85	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	206-211
15908181-0	2005	Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.	Epinephrine	0-10	Rap guanine nucleotide exchange factor 3	Homo sapiens	70-74
15908181-0	2005	Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline.	Epinephrine	124-134	AKT serine/threonine kinase 1	Homo sapiens	42-45
15908181-5	2005	Here we find that adrenaline alone did not influence PKB activation, but adrenaline dramatically potentiated insulin-stimulated phosphorylation of PKB (both Ser473 and Thr308) and of PKBalpha and PKBbeta enzyme activities.	Epinephrine	18-28	AKT serine/threonine kinase 1	Homo sapiens	147-150
15908181-5	2005	Here we find that adrenaline alone did not influence PKB activation, but adrenaline dramatically potentiated insulin-stimulated phosphorylation of PKB (both Ser473 and Thr308) and of PKBalpha and PKBbeta enzyme activities.	Epinephrine	18-28	AKT serine/threonine kinase 1	Homo sapiens	183-191
15908181-5	2005	Here we find that adrenaline alone did not influence PKB activation, but adrenaline dramatically potentiated insulin-stimulated phosphorylation of PKB (both Ser473 and Thr308) and of PKBalpha and PKBbeta enzyme activities.	Epinephrine	18-28	AKT serine/threonine kinase 2	Homo sapiens	196-203
15908181-5	2005	Here we find that adrenaline alone did not influence PKB activation, but adrenaline dramatically potentiated insulin-stimulated phosphorylation of PKB (both Ser473 and Thr308) and of PKBalpha and PKBbeta enzyme activities.	Epinephrine	73-83	AKT serine/threonine kinase 1	Homo sapiens	147-150
15908181-5	2005	Here we find that adrenaline alone did not influence PKB activation, but adrenaline dramatically potentiated insulin-stimulated phosphorylation of PKB (both Ser473 and Thr308) and of PKBalpha and PKBbeta enzyme activities.	Epinephrine	73-83	AKT serine/threonine kinase 1	Homo sapiens	183-191
15908181-5	2005	Here we find that adrenaline alone did not influence PKB activation, but adrenaline dramatically potentiated insulin-stimulated phosphorylation of PKB (both Ser473 and Thr308) and of PKBalpha and PKBbeta enzyme activities.	Epinephrine	73-83	AKT serine/threonine kinase 2	Homo sapiens	196-203
15908181-8	2005	Interestingly, the Epac specific cAMP analogue 8-(4-chlorophenylthio)-2"-O-methyl-cAMP potentiated insulin-stimulated PKB phosphorylation in a similar manner as adrenaline did without activating glycogen phosphorylase.	Epinephrine	161-171	Rap guanine nucleotide exchange factor 3	Homo sapiens	19-23
15908181-9	2005	Inhibition of PKA by H89 decreased adrenaline-stimulated glycogen phosphorylase activation but increased PKB activation, which further supports that adrenaline increases insulin-stimulated PKB phosphorylation via Epac.	Epinephrine	35-45	Rap guanine nucleotide exchange factor 3	Homo sapiens	213-217
15908181-9	2005	Inhibition of PKA by H89 decreased adrenaline-stimulated glycogen phosphorylase activation but increased PKB activation, which further supports that adrenaline increases insulin-stimulated PKB phosphorylation via Epac.	Epinephrine	149-159	AKT serine/threonine kinase 1	Homo sapiens	105-108
15908181-9	2005	Inhibition of PKA by H89 decreased adrenaline-stimulated glycogen phosphorylase activation but increased PKB activation, which further supports that adrenaline increases insulin-stimulated PKB phosphorylation via Epac.	Epinephrine	149-159	Rap guanine nucleotide exchange factor 3	Homo sapiens	213-217
15908181-11	2005	In conclusion, adrenaline potentiates insulin-stimulated activation of PKB and p70(S6K) via cAMP and Epac in skeletal muscle.	Epinephrine	15-25	AKT serine/threonine kinase 1	Homo sapiens	71-74
15908181-11	2005	In conclusion, adrenaline potentiates insulin-stimulated activation of PKB and p70(S6K) via cAMP and Epac in skeletal muscle.	Epinephrine	15-25	ribosomal protein S6 kinase B1	Homo sapiens	79-86
15908181-11	2005	In conclusion, adrenaline potentiates insulin-stimulated activation of PKB and p70(S6K) via cAMP and Epac in skeletal muscle.	Epinephrine	15-25	Rap guanine nucleotide exchange factor 3	Homo sapiens	101-105
16140489-0	2005	Changes in P2Y2 receptor localization on adrenaline- and noradrenaline-containing chromaffin cells in the rat adrenal gland during development and aging.	Epinephrine	41-51	purinergic receptor P2Y2	Rattus norvegicus	11-15
16277617-1	2005	Phenylethanolamine N-methyltransferase (PNMT, EC2.1.1.28) catalyzes the N-methylation of norepinephrine to form epinephrine.	Epinephrine	92-103	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
16277617-1	2005	Phenylethanolamine N-methyltransferase (PNMT, EC2.1.1.28) catalyzes the N-methylation of norepinephrine to form epinephrine.	Epinephrine	92-103	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
16277617-2	2005	As a step toward understanding the possible contribution of inheritance to individual variation in PNMT-catalyzed epinephrine formation, we "re-sequenced" the entire human PNMT gene, including the three exons, the introns and approximately 1 kb of the 5"-flanking region (5"-FR), using DNA samples from 60 African-American (AA) and 60 Caucasian-American (CA) subjects.	Epinephrine	114-125	phenylethanolamine N-methyltransferase	Homo sapiens	99-103
16277617-7	2005	These observations raise the possibility of inherited variation in the ability to form epinephrine from norepinephrine as a result of variant PNMT polymorphisms and haplotypes.	Epinephrine	87-98	phenylethanolamine N-methyltransferase	Homo sapiens	142-146
16311103-1	2005	Blockade of angiotensin II (ANGII) receptors or converting enzyme inhibition attenuates reflex increases in epinephrine during insulin-induced hypoglycemia.	Epinephrine	108-119	angiotensinogen	Rattus norvegicus	28-33
16140489-10	2005	However, during early development, when the chromaffin cells are actively dividing and during aging, when the adrenal medullary cells are known to show hyperplastic lesions, ATP acting through P2Y2 receptors may be involved in other physiological activities, such as proliferation and/or differentiation of the chromaffin cells associated with their adrenaline or noradrenaline phenotype.	Epinephrine	350-360	purinergic receptor P2Y2	Rattus norvegicus	193-197
16194531-2	2005	Many of these neurons express the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT), and are designated C1 neurons.	Epinephrine	34-44	phenylethanolamine-N-methyltransferase	Rattus norvegicus	105-109
16275192-5	2005	In contrast, QTc was significantly and consistently longer in subjects with LQT1 compared with controls during and after exercise (492 +/- 40 vs 407 +/- 14 ms, p &lt;0.0001, at peak exercise; 498 +/- 30 vs 399 +/- 20 ms, p &lt;0.0001, at 1 minute into recovery) or epinephrine (623 +/- 51 vs 499 +/- 51 ms, p &lt;0.001, at peak epinephrine; 604 +/- 36 vs 507 +/- 54 ms, p &lt;0.01, at 1 minute into recovery) but not in subjects with LQT2.	Epinephrine	265-276	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	76-80
16275192-5	2005	In contrast, QTc was significantly and consistently longer in subjects with LQT1 compared with controls during and after exercise (492 +/- 40 vs 407 +/- 14 ms, p &lt;0.0001, at peak exercise; 498 +/- 30 vs 399 +/- 20 ms, p &lt;0.0001, at 1 minute into recovery) or epinephrine (623 +/- 51 vs 499 +/- 51 ms, p &lt;0.001, at peak epinephrine; 604 +/- 36 vs 507 +/- 54 ms, p &lt;0.01, at 1 minute into recovery) but not in subjects with LQT2.	Epinephrine	328-339	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	76-80
16140489-4	2005	However, immunoreactivity for adrenaline-containing cells in the P2Y2 receptor-labeled chromaffin cells increased with increasing age and at 1 week post-natal almost all chromaffin cells were positive for both P2Y2 and phenyl ethanolamine-N-methyltransferase, while noradrenaline-containing cells were minimal.	Epinephrine	30-40	purinergic receptor P2Y2	Rattus norvegicus	65-69
16140489-4	2005	However, immunoreactivity for adrenaline-containing cells in the P2Y2 receptor-labeled chromaffin cells increased with increasing age and at 1 week post-natal almost all chromaffin cells were positive for both P2Y2 and phenyl ethanolamine-N-methyltransferase, while noradrenaline-containing cells were minimal.	Epinephrine	30-40	purinergic receptor P2Y2	Rattus norvegicus	210-214
16140489-6	2005	In the aging rat adrenals, P2Y2 receptor-immunoreactivity was localized in subpopulations of both adrenaline and noradrenaline-producing cells.	Epinephrine	98-108	purinergic receptor P2Y2	Rattus norvegicus	27-31
16051698-6	2005	Isoprenaline, noradrenaline, and adrenaline (-log EC(50) = 5.9, 5.5, and 5.7, respectively) stimulated an association between the beta(2)-adrenoceptor and beta-arrestin 2 at much higher concentrations than required for activation of cAMP accumulation (-log EC(50) = 7.6, 6.3, and 7.7, respectively).	Epinephrine	17-27	adrenergic receptor, beta 2	Mus musculus	130-150
16051698-6	2005	Isoprenaline, noradrenaline, and adrenaline (-log EC(50) = 5.9, 5.5, and 5.7, respectively) stimulated an association between the beta(2)-adrenoceptor and beta-arrestin 2 at much higher concentrations than required for activation of cAMP accumulation (-log EC(50) = 7.6, 6.3, and 7.7, respectively).	Epinephrine	17-27	arrestin, beta 2	Mus musculus	155-170
16268952-12	2005	Insulin injection increased plasma catecholamines on the average by 21.5% and 53.4% for adrenaline and noradrenaline respectively.	Epinephrine	88-98	insulin	Gallus gallus	0-7
16241953-8	2005	injection of collagen plus epinephrine, pretreatment with NCX-6550 (24-48 mg kg(-1)) significantly reduced platelet consumption, lung vessel occlusion and mortality.	Epinephrine	27-38	T cell leukemia, homeobox 2	Mus musculus	58-61
16463783-0	2005	[The influence of adrenaline on the expression of TGF-beta1, bFGF and I procollagen for hypertrophic scar].	Epinephrine	18-28	transforming growth factor beta 1	Homo sapiens	50-59
16463783-0	2005	[The influence of adrenaline on the expression of TGF-beta1, bFGF and I procollagen for hypertrophic scar].	Epinephrine	18-28	fibroblast growth factor 2	Homo sapiens	61-65
16463783-1	2005	OBJECTIVE: To investigate the influence of adrenaline on the expression of TGFbeta1, bFGF and procollagen for human normal and hypertrophic scar dermal fibroblasts cultured in vitro.	Epinephrine	43-53	transforming growth factor beta 1	Homo sapiens	75-83
16463783-1	2005	OBJECTIVE: To investigate the influence of adrenaline on the expression of TGFbeta1, bFGF and procollagen for human normal and hypertrophic scar dermal fibroblasts cultured in vitro.	Epinephrine	43-53	fibroblast growth factor 2	Homo sapiens	85-89
16463783-5	2005	RESULTS: In our study, adrenaline caused statistically significant increase in the peak levels of bFGF for normal and hypertrophic scar fibroblast cell lines (P &lt; 0.01).	Epinephrine	23-33	fibroblast growth factor 2	Homo sapiens	98-102
16463783-9	2005	CONCLUSIONS: We conclude from these results that adrenaline can increase the production of bFGF and decrease production of TGF-beta1 and I procollagen in human normal dermal and hypertrophic scar fibroblasts cultured in vitro.	Epinephrine	49-59	fibroblast growth factor 2	Homo sapiens	91-95
16463783-9	2005	CONCLUSIONS: We conclude from these results that adrenaline can increase the production of bFGF and decrease production of TGF-beta1 and I procollagen in human normal dermal and hypertrophic scar fibroblasts cultured in vitro.	Epinephrine	49-59	transforming growth factor beta 1	Homo sapiens	123-132
16039007-1	2005	Alpha1-adrenoreceptors (AR), of which three subtypes exist (alpha1A-, alpha1B- and alpha1D-AR) are G-protein-coupled receptors that mediate the actions of norepinephrine and epinephrine both peripherally and centrally.	Epinephrine	158-169	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	60-67
15923319-6	2005	Gene expression of TNF-alpha, IL-6, and IL-10 was markedly enhanced by epinephrine in EMCV-inoculated mice.	Epinephrine	71-82	tumor necrosis factor	Homo sapiens	19-28
15914506-4	2005	We found that epinephrine (1 microM) nearly halved insulin-stimulated 2-deoxyglucose uptake.	Epinephrine	14-25	insulin	Homo sapiens	51-58
15914506-5	2005	The beta-adrenoceptor antagonist propranolol (0.3 microM) completely antagonized the inhibitory effect of epinephrine on insulin-stimulated glucose uptake, whereas the alpha-adrenoceptor antagonist phentolamine (10 microM) had no effect.	Epinephrine	106-117	insulin	Homo sapiens	121-128
15914506-8	2005	Combination of ICI-118551 and SR-59230A, as well as combination of all three selective beta-adrenoceptor antagonists, abolished the effect of epinephrine on insulin-stimulated glucose uptake.	Epinephrine	142-153	insulin	Homo sapiens	157-164
16183425-10	2005	CONCLUSION: Endogenous production of physiological concentrations of insulin in response to exogenous glucose administration decreases serum potassium levels only in HD patients, independently of plasma aldosterone and epinephrine levels.	Epinephrine	219-230	insulin	Homo sapiens	69-76
15914506-10	2005	Both epinephrine and norepinephrine reduced insulin-stimulated GLUT4 translocation to the plasma membrane.	Epinephrine	5-16	insulin	Homo sapiens	44-51
15914506-10	2005	Both epinephrine and norepinephrine reduced insulin-stimulated GLUT4 translocation to the plasma membrane.	Epinephrine	5-16	solute carrier family 2 member 4	Homo sapiens	63-68
15923319-6	2005	Gene expression of TNF-alpha, IL-6, and IL-10 was markedly enhanced by epinephrine in EMCV-inoculated mice.	Epinephrine	71-82	interleukin 6	Homo sapiens	30-34
15923319-6	2005	Gene expression of TNF-alpha, IL-6, and IL-10 was markedly enhanced by epinephrine in EMCV-inoculated mice.	Epinephrine	71-82	interleukin 10	Homo sapiens	40-45
15870834-7	2005	ACTH increases were significantly correlated with increases in plasma nicotine (r=0.85; P&lt;0.0001), DHEA (r=0.66; P=0.002), and epinephrine (r=0.86; P&lt;0.0001).	Epinephrine	130-141	proopiomelanocortin	Homo sapiens	0-4
15961507-4	2005	Using different glutathione-S-transferase fusion proteins of AKAP 149, sequences containing the KH domain were required for inhibition of LPL translation, and the inhibition of AKAP 121 expression in 3T3-F442A adipocytes with short interfering RNA resulted in loss of epinephrine-mediated translation inhibition.	Epinephrine	268-279	A kinase (PRKA) anchor protein 1	Mus musculus	61-65
15961507-5	2005	After epinephrine injection into mice, LPL activity was inhibited in white adipose tissue but not in brown adipose tissue (BAT) or muscle.	Epinephrine	6-17	lipoprotein lipase	Mus musculus	39-42
15961507-6	2005	LPL activity and synthetic rate were inhibited in vitro by the addition of epinephrine to 3T3-F442A adipocytes, but there was no effect in L6 muscle cells and cultures of brown adipocytes.	Epinephrine	75-86	lipoprotein lipase	Mus musculus	0-3
15961507-8	2005	Thus, AKAP 121/149 contains a KH region that is essential to the translation inhibition of LPL in response to epinephrine.	Epinephrine	110-121	A kinase (PRKA) anchor protein 1	Mus musculus	6-14
15961507-8	2005	Thus, AKAP 121/149 contains a KH region that is essential to the translation inhibition of LPL in response to epinephrine.	Epinephrine	110-121	lipoprotein lipase	Mus musculus	91-94
15939797-2	2005	Norepinephrine and epinephrine act through three subtypes of beta-adrenoceptors (beta-AR) expressed in the adipocytes.	Epinephrine	3-14	adrenergic receptor, beta 3	Mus musculus	81-88
16194206-7	2005	Stimulation of the alpha(2A)-adrenergic receptor/G(z) pathway by epinephrine was able to replace the P2Y12/G(i)-mediated pathway to amplify Rac activation by FcgammaRIIa or by the thrombin receptor PAR-1.	Epinephrine	65-76	purinergic receptor P2Y12	Homo sapiens	101-106
16194206-7	2005	Stimulation of the alpha(2A)-adrenergic receptor/G(z) pathway by epinephrine was able to replace the P2Y12/G(i)-mediated pathway to amplify Rac activation by FcgammaRIIa or by the thrombin receptor PAR-1.	Epinephrine	65-76	AKT serine/threonine kinase 1	Homo sapiens	140-143
16194206-7	2005	Stimulation of the alpha(2A)-adrenergic receptor/G(z) pathway by epinephrine was able to replace the P2Y12/G(i)-mediated pathway to amplify Rac activation by FcgammaRIIa or by the thrombin receptor PAR-1.	Epinephrine	65-76	coagulation factor II thrombin receptor	Homo sapiens	198-203
16082697-0	2005	Randomized, placebo-controlled trial of albuterol and epinephrine at equipotent beta-2 agonist doses in acute bronchiolitis.	Epinephrine	54-65	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	80-86
16083857-1	2005	The human sulfotransferase, SULT1A3, catalyzes specifically the sulfonation of monoamines such as dopamine, epinephrine, and norepinephrine.	Epinephrine	108-119	sulfotransferase family 1A member 3	Homo sapiens	28-35
15985820-9	2005	Case reports support the use of the vasoconstrictors metaraminol, methoxamine and vasopressin if adrenaline is ineffective.	Epinephrine	97-107	arginine vasopressin	Homo sapiens	82-93
16170480-9	2005	It is suggested that exogenous epinephrine added to a local anesthetic may stimulate the presynaptic beta2 receptors on sympathetic nerve endings and on the adrenomedulla, and accelerate the release of endogenous epinephrine.	Epinephrine	31-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	101-106
15919153-8	2005	MGF was less effective than RA in stimulating the synthesis of epinephrine in the cells, and the additive effect of MGF and RA enhanced epinephrine synthesis.	Epinephrine	63-74	insulin like growth factor 1	Homo sapiens	0-3
15919153-8	2005	MGF was less effective than RA in stimulating the synthesis of epinephrine in the cells, and the additive effect of MGF and RA enhanced epinephrine synthesis.	Epinephrine	136-147	insulin like growth factor 1	Homo sapiens	116-119
16138261-10	2005	These results demonstrate that IN administration of ACTH(1-24) not only stimulates adrenocortical steroids, but also epinephrine and norepinephrine.	Epinephrine	117-128	proopiomelanocortin	Homo sapiens	52-56
16534265-3	2005	A multicentre trial compared arginine vasopressin and epinephrine in out-of-hospital cardiac arrest, and documented a significant improvement in hospital discharge rates in arginine vasopressin-treated (up to 2 x 40 IU) patients with asystole, and a significant benefit of the combined administration of arginine vasopressin and epinephrine on hospital discharge, irrespective of the underlying electrocardiographic rhythm.	Epinephrine	54-65	arginine vasopressin	Homo sapiens	182-193
16534265-3	2005	A multicentre trial compared arginine vasopressin and epinephrine in out-of-hospital cardiac arrest, and documented a significant improvement in hospital discharge rates in arginine vasopressin-treated (up to 2 x 40 IU) patients with asystole, and a significant benefit of the combined administration of arginine vasopressin and epinephrine on hospital discharge, irrespective of the underlying electrocardiographic rhythm.	Epinephrine	54-65	arginine vasopressin	Homo sapiens	182-193
16138261-6	2005	Sixty minutes after IN and IV administration of ACTH, epinephrine levels increased by 41.9 +/- 13.1 % and 63.3 +/- 11.8 %, respectively, and remained elevated throughout the sampling period.	Epinephrine	54-65	proopiomelanocortin	Homo sapiens	48-52
15955567-4	2005	CD14 expression in macrophages derived in vitro from CD59(+) cells following BI/S was significantly increased by epinephrine and this change was blocked by beta(2)-adrenergic receptor antagonist.	Epinephrine	113-124	CD14 molecule	Homo sapiens	0-4
15955567-4	2005	CD14 expression in macrophages derived in vitro from CD59(+) cells following BI/S was significantly increased by epinephrine and this change was blocked by beta(2)-adrenergic receptor antagonist.	Epinephrine	113-124	CD59 molecule (CD59 blood group)	Homo sapiens	53-57
15927391-1	2005	Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system.	Epinephrine	58-69	catechol-O-methyltransferase	Homo sapiens	0-28
15863506-3	2005	Moreover, TPO triggered platelet aggregation upon co-stimulation of G(z) by epinephrine but not upon co-stimulation of G(q) by the thromboxane analogue U46619.	Epinephrine	76-87	thrombopoietin	Homo sapiens	10-13
15908512-7	2005	In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol &gt; norepinephrine = epinephrine.	Epinephrine	89-100	adrenoceptor beta 1	Homo sapiens	135-142
15908512-7	2005	In the presence of alphaAR blockade, concentration-response curves for isoproterenol, norepinephrine, and epinephrine suggested that a beta1AR was involved in this response, and the rank order of potency was isoproterenol &gt; norepinephrine = epinephrine.	Epinephrine	106-117	adrenoceptor beta 1	Homo sapiens	135-142
16195034-5	2005	In the exercised group, the urinary noradrenaline/adrenaline ratio correlated positively with the training-induced changes in CD4+ T-lymphocytes and negatively with changes in the neutrophil/lymphocyte ratio.	Epinephrine	39-49	CD4 molecule	Homo sapiens	126-129
16049992-1	2005	OBJECTIVES: Tyrosine hydroxylase (TH) is a key enzyme in the biosynthesis of dopamine, epinephrine and norepinephrine.	Epinephrine	87-98	tyrosine hydroxylase	Homo sapiens	12-32
16049992-1	2005	OBJECTIVES: Tyrosine hydroxylase (TH) is a key enzyme in the biosynthesis of dopamine, epinephrine and norepinephrine.	Epinephrine	87-98	tyrosine hydroxylase	Homo sapiens	34-36
16009717-5	2005	Although FXII-deficient mice do not experience spontaneous or excessive injury-related bleeding, they are protected against collagen- and epinephrine-induced thromboembolism.	Epinephrine	138-149	coagulation factor XII (Hageman factor)	Mus musculus	9-13
15831569-3	2005	Based on the sources of the CART-immunoreactive (IR) innervation of the paraventricular nucleus, the putative origins of these CART-containing fibers include neurons of the hypothalamic arcuate nucleus that coexpress alphaMSH and medullary adrenaline-producing neurons.	Epinephrine	240-250	CART prepropeptide	Rattus norvegicus	127-131
15672411-7	2005	In fura-2 loaded PS1 (a prostate smooth muscle cell line) which express endogenous alpha1A-ARs, alpha-agonists epinephrine (EPI), and phenylephrine (PHE) induced Ca(2+) influx which depended on the extracellular Ca(2+) and PLC activation but was independent of PKC activation.	Epinephrine	111-122	presenilin 1	Rattus norvegicus	17-20
15927391-1	2005	Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system.	Epinephrine	58-69	catechol-O-methyltransferase	Homo sapiens	30-34
15896493-7	2005	Pharmacological inhibition of the synthesis of epinephrine, a potential neurotransmitter at central motoric alpha1-adrenoceptors, with 2,3-dichloro-alpha-methylbenzylamine also significantly attenuated orexin A-induced hyperactivity.	Epinephrine	47-58	hypocretin	Mus musculus	202-210
15850565-8	2005	In addition, the adrenergic agonists phenylephrine and adrenaline themselves, but not clonidine, induced PAI-1 with a spatial distribution similar to that of kainate (i.e. in coronary arteries throughout the heart, and in cardiocytes in the left ventricular and atrial myocardium).	Epinephrine	55-65	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	105-110
15922051-2	2005	Although the function of PDE4A in mammalian olfaction is unknown, patch clamp studies on deciliated olfactory receptor cells in the newt have shown that adrenaline or cAMP analogs can increase the contrast sensitivity to current injection.	Epinephrine	153-163	phosphodiesterase 4A	Homo sapiens	25-30
15939085-7	2005	Central TRH stimulated both corticosterone and epinephrine release.	Epinephrine	47-58	thyrotropin releasing hormone	Homo sapiens	8-11
15640395-9	2005	In conclusion, both acute exercise and epinephrine infusion decreased plasma leptin to a similar extent, whereas there was no effect with rhIL-6 infusion.	Epinephrine	39-50	leptin	Homo sapiens	77-83
15898286-0	2005	The effect of lidocaine and adrenaline on the viability of injected adipose tissue--an experimental study in nude mice.	Epinephrine	28-38	WD and tetratricopeptide repeats 1	Mus musculus	68-75
15637118-9	2005	Blocking antibodies against ICAM-1, E-selectin, and L-selectin significantly inhibited epinephrine-enhanced PMN adhesion, whereas anti-VCAM-1 had lesser effects.	Epinephrine	87-98	intercellular adhesion molecule 1	Mus musculus	28-34
15637118-9	2005	Blocking antibodies against ICAM-1, E-selectin, and L-selectin significantly inhibited epinephrine-enhanced PMN adhesion, whereas anti-VCAM-1 had lesser effects.	Epinephrine	87-98	selectin, endothelial cell	Mus musculus	36-46
15637118-9	2005	Blocking antibodies against ICAM-1, E-selectin, and L-selectin significantly inhibited epinephrine-enhanced PMN adhesion, whereas anti-VCAM-1 had lesser effects.	Epinephrine	87-98	selectin, lymphocyte	Mus musculus	52-62
15841207-5	2005	Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine).	Epinephrine	255-266	renalase, FAD dependent amine oxidase	Homo sapiens	98-106
15841207-5	2005	Here we report the identification of a novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood by the kidney and metabolizes catecholamines in vitro (renalase metabolizes dopamine most efficiently, followed by epinephrine, and then norepinephrine).	Epinephrine	255-266	renalase, FAD dependent amine oxidase	Homo sapiens	195-203
15824970-1	2005	PNMT (phenylethanolamine-N-methyl-transferase) is the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	93-104	phenylethanolamine-N-methyltransferase	Mus musculus	0-4
15930502-5	2005	In mice lacking norepinephrine and epinephrine, many of these regions exhibited significantly reduced activation (e.g., hippocampal CA1), while other regions did not (e.g., hippocampal CA3).	Epinephrine	19-30	carbonic anhydrase 1	Mus musculus	132-135
15886804-8	2005	Furthermore, epinephrine, acting via inhibitory Gz-coupled alpha(2A)-adrenoceptors, bypasses the inhibitory effect of AR-C69931MX on thrombin-induced p27 and p31 tyrosine phosphorylation.	Epinephrine	13-24	coagulation factor II, thrombin	Homo sapiens	133-141
15886804-8	2005	Furthermore, epinephrine, acting via inhibitory Gz-coupled alpha(2A)-adrenoceptors, bypasses the inhibitory effect of AR-C69931MX on thrombin-induced p27 and p31 tyrosine phosphorylation.	Epinephrine	13-24	interferon alpha inducible protein 27	Homo sapiens	150-153
15886804-8	2005	Furthermore, epinephrine, acting via inhibitory Gz-coupled alpha(2A)-adrenoceptors, bypasses the inhibitory effect of AR-C69931MX on thrombin-induced p27 and p31 tyrosine phosphorylation.	Epinephrine	13-24	proteasome 26S subunit, non-ATPase 8	Homo sapiens	158-161
15774080-7	2005	Vasopressin has been shown to result in greater blood flow diversion from nonvital to vital organ beds compared with adrenaline (epinephrine).	Epinephrine	129-140	arginine vasopressin	Homo sapiens	0-11
16146256-1	2005	OBJECTIVE: To compare the effectiveness and side effects of nebulized l-epinephrine (NLE) at a dose of 0.05 mL/kg versus 0.5 mL/kg in the treatment of postintubation croup in children.	Epinephrine	70-83	notchless homolog 1	Homo sapiens	85-88
15620421-9	2005	The PrRP immunopositive cells were double positive for tyrosine hydroxylase (TH) and for phenylethanolamine N-methyltransferase (PNMT), which indicates that PrRP may be produced in a part of the adrenaline cells in the adrenal gland.	Epinephrine	195-205	prolactin releasing hormone	Rattus norvegicus	4-8
15620421-9	2005	The PrRP immunopositive cells were double positive for tyrosine hydroxylase (TH) and for phenylethanolamine N-methyltransferase (PNMT), which indicates that PrRP may be produced in a part of the adrenaline cells in the adrenal gland.	Epinephrine	195-205	tyrosine hydroxylase	Rattus norvegicus	55-75
15620421-9	2005	The PrRP immunopositive cells were double positive for tyrosine hydroxylase (TH) and for phenylethanolamine N-methyltransferase (PNMT), which indicates that PrRP may be produced in a part of the adrenaline cells in the adrenal gland.	Epinephrine	195-205	phenylethanolamine-N-methyltransferase	Rattus norvegicus	89-127
15620421-9	2005	The PrRP immunopositive cells were double positive for tyrosine hydroxylase (TH) and for phenylethanolamine N-methyltransferase (PNMT), which indicates that PrRP may be produced in a part of the adrenaline cells in the adrenal gland.	Epinephrine	195-205	prolactin releasing hormone	Rattus norvegicus	157-161
15620421-10	2005	This is the first report that PrRP is produced in the adrenaline-containing cells of the adrenal gland.	Epinephrine	54-64	prolactin releasing hormone	Rattus norvegicus	30-34
15836982-2	2005	PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).	Epinephrine	73-84	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	138-141
15836982-2	2005	PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).	Epinephrine	73-84	protein kinase C, epsilon	Rattus norvegicus	143-166
15836982-2	2005	PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).	Epinephrine	73-84	protein kinase C, epsilon	Rattus norvegicus	168-178
15836982-2	2005	PGE(2)-induced hyperalgesia is mediated by protein kinase A (PKA), while epinephrine-induced hyperalgesia is mediated by a combination of PKA, protein kinase Cepsilon (PKCepsilon) and mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK).	Epinephrine	73-84	Eph receptor B1	Rattus norvegicus	261-264
15752739-3	2005	Here, we reported that adrenaline, a hormone mediating the biological activities of stress, upregulates mdr1 gene expression in MCF-7 breast cancer cells via alpha(2)-adrenergic receptors in a dose-dependent manner.	Epinephrine	23-33	ATP binding cassette subfamily B member 1	Homo sapiens	104-108
15601628-1	2005	2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (PACA), pharmacological inhibitor of phospholipase A(2) (PLA(2)), inhibits epinephrine-stimulated thromboxane production in human platelets.	Epinephrine	121-132	pancreas associated transcription factor 1a	Homo sapiens	47-51
15601628-1	2005	2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (PACA), pharmacological inhibitor of phospholipase A(2) (PLA(2)), inhibits epinephrine-stimulated thromboxane production in human platelets.	Epinephrine	121-132	phospholipase A2 group IB	Homo sapiens	83-101
15601628-1	2005	2-(p-amylcinnamoyl)amino-4-chlorobenzoic acid (PACA), pharmacological inhibitor of phospholipase A(2) (PLA(2)), inhibits epinephrine-stimulated thromboxane production in human platelets.	Epinephrine	121-132	phospholipase A2 group IB	Homo sapiens	103-109
15756641-4	2005	beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration.	Epinephrine	22-33	adrenoceptor beta 2	Homo sapiens	0-7
15756641-4	2005	beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration.	Epinephrine	22-33	tumor necrosis factor	Homo sapiens	147-156
15756641-4	2005	beta2AR activation by epinephrine, norepinephrine, and salbutamol suppressed the IgE receptor-dependent release of histamine, lipid mediators, and TNF-alpha, and inhibited SCF-dependent MC proliferation and migration.	Epinephrine	22-33	KIT ligand	Homo sapiens	172-175
15536204-8	2005	Epinephrine increased mannose output from the perfused liver of fed rats, but this effect was negated in the presence of a glucose-6-phosphatase inhibitor.	Epinephrine	0-11	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	123-144
15578203-5	2005	Plasma epinephrine concentrations were significantly higher in CAF compared with PLA at pre-exercise [0.28 (0.05) nmol l(-1) versus 0.08 (0.03) nmol l(-1), P&lt;0.01; mean (SE)] and immediately post-exercise [1.02 (0.16) nmol l(-1) versuss 0.60 (0.13) nmol l(-1), P&lt;0.01].	Epinephrine	7-18	lysine acetyltransferase 2B	Homo sapiens	63-66
15523499-1	2005	The beta-adrenergic receptors (beta-AR) are G protein-coupled receptors activated by epinephrine and norepinephrine and are involved in a variety of their physiological functions.	Epinephrine	85-96	adrenoceptor beta 1	Homo sapiens	31-38
15824970-1	2005	PNMT (phenylethanolamine-N-methyl-transferase) is the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	93-104	phenylethanolamine-N-methyltransferase	Mus musculus	6-45
15494609-13	2005	Furthermore, impaired epinephrine counterregulation in diabetes is associated with reduced adrenal TH mRNA, whereas the additional epinephrine defect after recurrent hypoglycemia is associated with decreases in both TH and PNMT mRNA.	Epinephrine	22-33	tyrosine hydroxylase	Rattus norvegicus	99-101
15710461-1	2005	Previous studies indicate that norepinephrine and epinephrine modulate production of interleukin-1(beta) (IL-1(beta)) by activated macrophages, but it is not known if macrophage-derived catecholamines affect IL-1(beta).	Epinephrine	34-45	interleukin 1 beta	Mus musculus	85-104
15733182-1	2005	AIMS: To explore effects of epinephrine and phenylephrine on the behavior of right ventricular monophasic action potentials (MAPs) in symptomatic LQT1 and LQT2 patients.	Epinephrine	28-39	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	146-150
15733182-1	2005	AIMS: To explore effects of epinephrine and phenylephrine on the behavior of right ventricular monophasic action potentials (MAPs) in symptomatic LQT1 and LQT2 patients.	Epinephrine	28-39	potassium voltage-gated channel subfamily H member 2	Homo sapiens	155-159
15733182-5	2005	Epinephrine prolonged MAP50-to-MAP90 duration and increased the rate dependence of MAP90 duration and increased restitution rate in type LQT1, but not in LQT2 patients nor in control subjects.	Epinephrine	0-11	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	137-141
15494609-7	2005	Remarkably, mRNA for phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, was reduced (P &lt; 0.05 vs. all) 40% only in D-hypo rats.	Epinephrine	86-97	phenylethanolamine-N-methyltransferase	Rattus norvegicus	21-59
15848714-1	2005	BACKGROUND: Phenylethanolamine N-methyltransferase (PNMT) is an enzyme involved in the epinephrine synthesis.	Epinephrine	87-98	phenylethanolamine N-methyltransferase	Homo sapiens	12-50
15848714-1	2005	BACKGROUND: Phenylethanolamine N-methyltransferase (PNMT) is an enzyme involved in the epinephrine synthesis.	Epinephrine	87-98	phenylethanolamine N-methyltransferase	Homo sapiens	52-56
15609375-7	2005	On complex formation with adrenaline, the syn-conformer becomes dominant due to an intramolecular dipole-reversal effect in addition to multipoint hydrogen bonding.	Epinephrine	26-36	synemin	Homo sapiens	42-45
15673886-8	2005	Epinephrine significantly enhanced platelet-neutrophil adhesion and P-selectin and glycoprotein IIb/IIIa expression on platelets.	Epinephrine	0-11	selectin P	Homo sapiens	68-78
15673886-10	2005	beta-Adrenergic blockade before incubation with epinephrine increased platelet-neutrophil aggregates and adhesion molecule expression (CD11b, P-selectin, and glycoprotein IIb/IIIa) even further.	Epinephrine	48-59	integrin subunit alpha M	Homo sapiens	135-140
15456839-1	2005	Chronic coactivation of alpha(2B)- and beta(2)-adrenoceptors (AR) was recently reported to down-regulate the alpha(2B)-AR at a lower threshold epinephrine (EPI) concentration compared with the activation of alpha(2B)-AR alone.	Epinephrine	143-154	adrenoceptor alpha 2B	Homo sapiens	109-121
15494609-7	2005	Remarkably, mRNA for phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine to epinephrine, was reduced (P &lt; 0.05 vs. all) 40% only in D-hypo rats.	Epinephrine	86-97	phenylethanolamine-N-methyltransferase	Rattus norvegicus	61-65
15770879-8	2005	Variables associated with higher concentrations of TNFalpha were; lower ejection fraction (P=0.04), worse functional class (P=0.007), coronary artery disease (P=0.05), chronic renal failure (P=0.02), arterial hypertension (P=0.05), higher concentrations of epinephrine (P=0.03) and norepinephrine (P=0.05).	Epinephrine	257-268	tumor necrosis factor	Homo sapiens	51-59
15851286-2	2005	BACKGROUND: QT prolongation is a paradoxical, LQT1-specific response to low-dose epinephrine infusion.	Epinephrine	81-92	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	46-50
15851286-8	2005	During epinephrine infusion, G1- and G2-T waves were more common in LQT2 than in LQT1 (75% vs 26%, P = .009).	Epinephrine	7-18	potassium voltage-gated channel subfamily H member 2	Homo sapiens	68-72
15851286-8	2005	During epinephrine infusion, G1- and G2-T waves were more common in LQT2 than in LQT1 (75% vs 26%, P = .009).	Epinephrine	7-18	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	81-85
15851286-10	2005	Epinephrine-precipitated biphasic T waves were observed similarly in all groups: LQT1 (6/30), LQT2 (3/28), and control (4/32).	Epinephrine	0-11	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	81-85
15851286-10	2005	Epinephrine-precipitated biphasic T waves were observed similarly in all groups: LQT1 (6/30), LQT2 (3/28), and control (4/32).	Epinephrine	0-11	potassium voltage-gated channel subfamily H member 2	Homo sapiens	94-98
15851286-11	2005	During low-dose epinephrine infusion (&lt; or =0.05 microg/kg/min), G1-T waves occurred more frequently in LQT2 (LQT1: 25% vs 3%; control 9%, P = .02).	Epinephrine	16-27	potassium voltage-gated channel subfamily H member 2	Homo sapiens	107-111
15851286-11	2005	During low-dose epinephrine infusion (&lt; or =0.05 microg/kg/min), G1-T waves occurred more frequently in LQT2 (LQT1: 25% vs 3%; control 9%, P = .02).	Epinephrine	16-27	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	113-117
15851286-12	2005	Low-dose epinephrine-induced G2-T waves were detected exclusively in LQT2 (18%).	Epinephrine	9-20	potassium voltage-gated channel subfamily H member 2	Homo sapiens	69-73
15851286-16	2005	G2-notched T waves elicited during low-dose epinephrine may unmask some patients with concealed LQT2.	Epinephrine	44-55	potassium voltage-gated channel subfamily H member 2	Homo sapiens	96-100
15851288-9	2005	DeltaQT, SD-DeltaQT, and QTI were increased in LQT1 but not in control patients during epinephrine (LQT1: DeltaQT 2.3-4.2 ms, SD-DeltaQT 2.2-4.1, QTI 0.10-0.22, P &lt; .005 vs baseline; CONTROL: DeltaQT 2.5-2.4 ms, SD-DeltaQT 1.9-2.1, QTI 0.08-0.09: P = NS vs baseline).	Epinephrine	87-98	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	47-51
15851288-10	2005	CONCLUSIONS: Beat-by-beat QT variability analyzed by the cross-correlation method was greater in LQT1 patients during epinephrine infusion, suggesting sympathetic stimulation accentuates beat-by-beat alternation of repolarization in LQT1 patients.	Epinephrine	118-129	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	97-101
15851288-10	2005	CONCLUSIONS: Beat-by-beat QT variability analyzed by the cross-correlation method was greater in LQT1 patients during epinephrine infusion, suggesting sympathetic stimulation accentuates beat-by-beat alternation of repolarization in LQT1 patients.	Epinephrine	118-129	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	233-237
15673663-1	2005	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Epinephrine	91-102	catechol-O-methyltransferase	Homo sapiens	0-28
15673663-1	2005	Catechol-O-methyltransferase (COMT) degrades the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine.	Epinephrine	91-102	catechol-O-methyltransferase	Homo sapiens	30-34
16463884-7	2005	Finally, we examined the impact of epinephrine infusion on blood IL-10 levels.	Epinephrine	35-46	interleukin 10	Homo sapiens	65-70
15579373-5	2005	Besides, we showed IL-6sR release during platelet activation induced by thrombin and a complex of ADP and epinephrine.	Epinephrine	106-117	interleukin 6 receptor	Homo sapiens	19-25
16463884-10	2005	Furthermore, epinephrine infusion directly induced systemic release of IL-10.	Epinephrine	13-24	interleukin 10	Homo sapiens	71-76
16038718-6	2005	Activation of the platelets (P-selectin expression) was significantly reduced by 10-40% in resting platelets, TRAP-activated and hydrogen peroxide-stressed platelets and epinephrine pre-activated platelets relative to controls.	Epinephrine	170-181	selectin P	Homo sapiens	29-39
15968085-1	2005	Transcription of the gene encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT, E.C.	Epinephrine	39-50	phenylethanolamine N-methyltransferase	Homo sapiens	71-109
15968085-1	2005	Transcription of the gene encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT, E.C.	Epinephrine	39-50	phenylethanolamine N-methyltransferase	Homo sapiens	111-115
15607574-4	2005	High fasting and postprandial insulin levels can increase adipocyte exposure to catcholamines by activating the sympathetic nervous system, as well as by provoking postabsorptive hypoglycemia that triggers adrenal secretion of epinephrine.	Epinephrine	227-238	insulin	Homo sapiens	30-37
15459114-6	2005	Epinephrine inhibited apoptosis induced by the P2X7 receptor ligand 2",3"-0-(4-benzoylbenzoyl)-ATP, by attenuation of P2X7 receptor plasma membrane pore formation.	Epinephrine	0-11	purinergic receptor P2X 7	Homo sapiens	47-60
15459114-6	2005	Epinephrine inhibited apoptosis induced by the P2X7 receptor ligand 2",3"-0-(4-benzoylbenzoyl)-ATP, by attenuation of P2X7 receptor plasma membrane pore formation.	Epinephrine	0-11	purinergic receptor P2X 7	Homo sapiens	118-131
15459114-8	2005	CaSki cells express the beta2-adrenoceptor, and the epinephrine antiapoptotic effect could be mimicked by beta2-adrenoceptor agonists and by activators of adenylyl cyclase.	Epinephrine	52-63	adrenoceptor beta 2	Homo sapiens	106-124
15459114-10	2005	Western immunoblot analysis revealed that epinephrine decreased the levels of the glycosylated 85-kDa form of the P2X7 receptor and increased receptor degradation, and that EGF potentiated these effects of epinephrine.	Epinephrine	42-53	purinergic receptor P2X 7	Homo sapiens	114-127
15459114-10	2005	Western immunoblot analysis revealed that epinephrine decreased the levels of the glycosylated 85-kDa form of the P2X7 receptor and increased receptor degradation, and that EGF potentiated these effects of epinephrine.	Epinephrine	206-217	purinergic receptor P2X 7	Homo sapiens	114-127
16435190-9	2005	The ratios of brain noradrenaline to dopamine and of adrenaline to dopamine were also increased by the treatment, suggesting that the activity of dopamine beta-hydroxylase, a copper-dependent enzyme, was improved by the treatment.	Epinephrine	23-33	dopamine beta hydroxylase	Mus musculus	146-171
15689106-0	2004	Effect of urate on the lactoperoxidase catalyzed oxidation of adrenaline.	Epinephrine	62-72	lactoperoxidase	Homo sapiens	23-38
15591341-6	2004	Epinephrine-stimulated glycerol secretion was also impaired in Aqp7 knockdown adipocytes.	Epinephrine	0-11	aquaporin 7	Mus musculus	63-67
15308566-2	2004	We have now found that up-regulation of intracellular cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) by epinephrine significantly increased sickle but not normal erythrocyte adhesion to both primary and immortalized ECs.	Epinephrine	128-139	Protein kinase, cAMP-dependent, catalytic subunit 1	Drosophila melanogaster	120-123
15518886-1	2004	Chromogranin A (CgA) is a member of a family of chromogranins, which are co-stored and co-released with adrenaline and noradrenalin (NAd) in the adrenal medulla in response to stimulation of the splanchnic nerve.	Epinephrine	104-114	chromogranin A	Rattus norvegicus	0-14
15518886-1	2004	Chromogranin A (CgA) is a member of a family of chromogranins, which are co-stored and co-released with adrenaline and noradrenalin (NAd) in the adrenal medulla in response to stimulation of the splanchnic nerve.	Epinephrine	104-114	chromogranin A	Rattus norvegicus	16-19
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Epinephrine	0-11	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	89-92
15616384-7	2004	In hypodynamic animal models of sepsis vasopressin compromised oxygen delivery and decreased systemic and gut blood flow.High-dose bolus vasopressin appeared promising in animal studies of hemorrhagic shock and cardiopulmonary arrest and in a large, randomized clinical trial of vasopressin versus epinephrine in human cardiopulmonary arrest with asystole.	Epinephrine	298-309	arginine vasopressin	Homo sapiens	137-148
15616384-7	2004	In hypodynamic animal models of sepsis vasopressin compromised oxygen delivery and decreased systemic and gut blood flow.High-dose bolus vasopressin appeared promising in animal studies of hemorrhagic shock and cardiopulmonary arrest and in a large, randomized clinical trial of vasopressin versus epinephrine in human cardiopulmonary arrest with asystole.	Epinephrine	298-309	arginine vasopressin	Homo sapiens	137-148
15385622-4	2004	We found that catecholamines (l-3,4-hydroxyphenylalanine [l-dopa], dopamine, adrenaline, and noradrenaline) elevate FUS1 and RLM1 transcription.	Epinephrine	77-87	Fus1p	Saccharomyces cerevisiae S288C	116-120
15385622-4	2004	We found that catecholamines (l-3,4-hydroxyphenylalanine [l-dopa], dopamine, adrenaline, and noradrenaline) elevate FUS1 and RLM1 transcription.	Epinephrine	77-87	Rlm1p	Saccharomyces cerevisiae S288C	125-129
15582762-0	2004	Vasopressin administered with epinephrine is associated with a return of a pulse in out-of-hospital cardiac arrest.	Epinephrine	30-41	arginine vasopressin	Homo sapiens	0-11
15582762-11	2004	Subjects receiving vasopressin and epinephrine were more likely to have a return of pulses during the resuscitation (LR: 2.73; 95% CI: 1.24, 6.03) and at hospital arrival (3.85; 1.71, 8.65) than subjects treated with epinephrine alone.	Epinephrine	217-228	arginine vasopressin	Homo sapiens	19-30
22900357-4	2004	Zymographic analysis showed that treatment with hormones like epinephrine, thyroxine and dexamethasone and Bt2 cAMP increased 92 kDa MMP-9 activity.	Epinephrine	62-73	matrix metallopeptidase 9	Rattus norvegicus	133-138
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Epinephrine	0-11	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	93-97
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Epinephrine	0-11	glutamate ionotropic receptor NMDA type subunit 1 L homeolog	Xenopus laevis	102-105
15500961-8	2004	Epinephrine, norepinephrine and octopamine also weakly inhibited macroscopic currents at NR1/NR2A and NR1/NR2B receptors.	Epinephrine	0-11	glutamate receptor ionotropic, NMDA 2B	Xenopus laevis	106-110
15502056-5	2004	Therefore, we examined the effects of various adrenergic drugs (dobutamine, xamoterol, clenbuterol, epinephrine, norepinephrine, and phenylephrine) on the activation of NF-kappaB, on the NF-kappaB-driven reporter gene activity, and on the expression of the NF-kappaB target gene interleukin (IL)-8.	Epinephrine	100-111	nuclear factor kappa B subunit 1	Homo sapiens	169-178
15536607-1	2004	It has been hypothesized that epinephrine may stimulate interleukin (IL)-6 gene expression in skeletal muscle.	Epinephrine	30-41	interleukin 6	Rattus norvegicus	56-74
15536607-9	2004	These data demonstrate that while pharmacologic concentrations of epinephrine activate IL-6 mRNA, supraphysiologic and high-physiologic doses appear to have little, if any, effect on IL-6 gene transcription in skeletal muscle.	Epinephrine	66-77	interleukin 6	Rattus norvegicus	87-91
15369781-3	2004	In contrast, transcripts of phenylethanolamine-N-methyltransferase, the enzyme catalyzing the conversion of norepinephrine into epinephrine, were not detected in aortae in either mouse strain.	Epinephrine	111-122	phenylethanolamine-N-methyltransferase	Mus musculus	28-66
15383152-7	2004	However, IL-6, IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine.	Epinephrine	106-117	interleukin 6	Homo sapiens	9-13
15124004-1	2004	The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Epinephrine	156-167	catechol-O-methyltransferase	Homo sapiens	11-39
15124004-1	2004	The enzyme catechol-o-methyltransferase (COMT) transfers a methyl group from adenosylmethionine to catecholamines including the neurotransmitters dopamine, epinephrine and norepinephrine.	Epinephrine	156-167	catechol-O-methyltransferase	Homo sapiens	41-45
15383152-7	2004	However, IL-6, IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine.	Epinephrine	106-117	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
15180973-0	2004	Epinephrine infusion increases adipose interleukin-6 gene expression and systemic levels in humans.	Epinephrine	0-11	interleukin 6	Homo sapiens	39-52
15180973-2	2004	We, therefore, explored the possible role of epinephrine in the induction of IL-6 in adipose tissue.	Epinephrine	45-56	interleukin 6	Homo sapiens	77-81
15180973-5	2004	The level of IL-6 mRNA in subcutaneous adipose tissue increased 26-fold (95% confidence interval, 9- to 166-fold) at 3 h of epinephrine infusion compared with controls (P=0.028).	Epinephrine	124-135	interleukin 6	Homo sapiens	13-17
15180973-6	2004	In addition, plasma levels of IL-6 increased in response to epinephrine infusion (P &lt;0.001).	Epinephrine	60-71	interleukin 6	Homo sapiens	30-34
15525607-10	2004	Incubating human primary myotubes with epinephrine increased PGC1alpha independently of changes in p38 MAPK phosphorylation.	Epinephrine	39-50	PPARG coactivator 1 alpha	Homo sapiens	61-70
15525607-12	2004	We suggest that the increase in PGC1alpha may be due to the elevated plasma epinephrine levels.	Epinephrine	76-87	PPARG coactivator 1 alpha	Homo sapiens	32-41
15476943-5	2004	In conscious sheep, intracerebroventricular administration of UII induced large, prolonged increases in plasma epinephrine, adrenocorticotropic hormone, cardiac output and arterial pressure.	Epinephrine	111-122	urotensin 2	Rattus norvegicus	62-65
15383152-7	2004	However, IL-6, IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine.	Epinephrine	106-117	interleukin 13	Homo sapiens	25-30
15220331-4	2004	Treatment of human aortic smooth muscle cell with epinephrine inhibits migration to fibronectin and vitronectin, and the inhibition is blocked by the alpha(1)-adrenoreceptor antagonist prazosin or chloroethylclonidine.	Epinephrine	50-61	fibronectin 1	Homo sapiens	84-95
15383152-7	2004	However, IL-6, IL-8, and IL-13 production induced by IL-1 beta were significantly enhanced by addition of epinephrine.	Epinephrine	106-117	interleukin 1 beta	Homo sapiens	53-62
15363956-0	2004	Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.	Epinephrine	101-111	lipase G, endothelial type	Rattus norvegicus	13-19
15363956-0	2004	Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.	Epinephrine	101-111	arginine vasopressin	Rattus norvegicus	67-78
15363956-2	2004	administered arginine-vasopressin evokes the release of noradrenaline and adrenaline from adrenal medulla by brain thromboxane A2-mediated mechanisms in rats.	Epinephrine	59-69	arginine vasopressin	Rattus norvegicus	22-33
15363956-13	2004	These results suggest that vasopressin evokes the release of noradrenaline and adrenaline from adrenal medulla by the brain PLC- and diacylglycerol lipase-dependent mechanisms in rats.	Epinephrine	64-74	arginine vasopressin	Rattus norvegicus	27-38
15851169-2	2004	BACKGROUND: A differential response of dynamic QT interval to epinephrine infusion between LQT1, LQT2, and LQT3 syndromes has been reported, indicating the potential diagnostic value of the epinephrine test for genotyping the three forms.	Epinephrine	62-73	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	91-95
15851169-2	2004	BACKGROUND: A differential response of dynamic QT interval to epinephrine infusion between LQT1, LQT2, and LQT3 syndromes has been reported, indicating the potential diagnostic value of the epinephrine test for genotyping the three forms.	Epinephrine	62-73	potassium voltage-gated channel subfamily H member 2	Homo sapiens	97-101
15851169-2	2004	BACKGROUND: A differential response of dynamic QT interval to epinephrine infusion between LQT1, LQT2, and LQT3 syndromes has been reported, indicating the potential diagnostic value of the epinephrine test for genotyping the three forms.	Epinephrine	190-201	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	91-95
15851169-2	2004	BACKGROUND: A differential response of dynamic QT interval to epinephrine infusion between LQT1, LQT2, and LQT3 syndromes has been reported, indicating the potential diagnostic value of the epinephrine test for genotyping the three forms.	Epinephrine	190-201	potassium voltage-gated channel subfamily H member 2	Homo sapiens	97-101
15851169-6	2004	RESULTS: The sensitivity (penetrance) by ECG diagnostic criteria was lower in LQT1 (68%) than in LQT2 (83%) or LQT3 (83%) before epinephrine and was improved with steady-state epinephrine in LQT1 (87%) and LQT2 (91%) but not in LQT3 (83%), without the expense of specificity (100%).	Epinephrine	176-187	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	78-82
15851169-6	2004	RESULTS: The sensitivity (penetrance) by ECG diagnostic criteria was lower in LQT1 (68%) than in LQT2 (83%) or LQT3 (83%) before epinephrine and was improved with steady-state epinephrine in LQT1 (87%) and LQT2 (91%) but not in LQT3 (83%), without the expense of specificity (100%).	Epinephrine	176-187	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	191-195
15851169-6	2004	RESULTS: The sensitivity (penetrance) by ECG diagnostic criteria was lower in LQT1 (68%) than in LQT2 (83%) or LQT3 (83%) before epinephrine and was improved with steady-state epinephrine in LQT1 (87%) and LQT2 (91%) but not in LQT3 (83%), without the expense of specificity (100%).	Epinephrine	176-187	potassium voltage-gated channel subfamily H member 2	Homo sapiens	206-210
15851169-6	2004	RESULTS: The sensitivity (penetrance) by ECG diagnostic criteria was lower in LQT1 (68%) than in LQT2 (83%) or LQT3 (83%) before epinephrine and was improved with steady-state epinephrine in LQT1 (87%) and LQT2 (91%) but not in LQT3 (83%), without the expense of specificity (100%).	Epinephrine	176-187	sodium voltage-gated channel alpha subunit 5	Homo sapiens	228-232
15851169-9	2004	CONCLUSIONS: Epinephrine infusion is a powerful test to predict the genotype of LQT1, LQT2, and LQT3 syndromes as well as to improve the clinical diagnosis of genotype-positive patients, especially those with LQT1 syndrome.	Epinephrine	13-24	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	80-84
15851169-9	2004	CONCLUSIONS: Epinephrine infusion is a powerful test to predict the genotype of LQT1, LQT2, and LQT3 syndromes as well as to improve the clinical diagnosis of genotype-positive patients, especially those with LQT1 syndrome.	Epinephrine	13-24	potassium voltage-gated channel subfamily H member 2	Homo sapiens	86-90
15327388-5	2004	RESULTS: The rank orders of responses to ligands for ADPKD and ARPKD cells were identical: epinephrine &gt; desmopressin (DDAVP) approximately arginine vasopressin (AVP) &gt; adenosine &gt; prostaglandin E(2) (PGE(2)) &gt; parathyroid hormone (PTH).	Epinephrine	91-102	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	63-68
15508673-9	2004	Vasopressin followed by epinephrine was more effective than epinephrine alone in the treatment of refractory cardiac arrest.	Epinephrine	60-71	arginine vasopressin	Homo sapiens	0-11
15123766-7	2004	In organ chamber experiments, ex vivo incubation (18 h) of rat aortic rings with the organic subfraction of ALE enhanced the NO-mediated vasodilator response to acetylcholine, indicating that the up-regulated eNOS remained functional.	Epinephrine	108-111	nitric oxide synthase 3	Rattus norvegicus	209-213
15220331-4	2004	Treatment of human aortic smooth muscle cell with epinephrine inhibits migration to fibronectin and vitronectin, and the inhibition is blocked by the alpha(1)-adrenoreceptor antagonist prazosin or chloroethylclonidine.	Epinephrine	50-61	vitronectin	Homo sapiens	100-111
15234252-2	2004	Leptin transport is saturable and regulated by epinephrine, triglycerides, and starvation.	Epinephrine	47-58	leptin	Homo sapiens	0-6
15222975-9	2004	This was functionally demonstrated in vitro by increased uptake of human IgA by acutely prepared rat salivary cells following stimulation by adrenaline, indicating increased mobilisation of pIgR with stimulation.	Epinephrine	141-151	polymeric immunoglobulin receptor	Rattus norvegicus	190-194
15281015-7	2004	In these cells glucose oxidation to CO2 was effected equally, but glargine was less potent than insulin at inhibiting epinephrine-stimulated lipolysis (EC50 = 1.4 v 0.35 nmol/L, P &lt; .001) and at stimulating lipogenesis (EC50 = 1.27 v 8.06 nmol/L, P &lt; .01).	Epinephrine	118-129	insulin	Homo sapiens	96-103
15210061-5	2004	RESULTS: The data show that a synergism in platelet aggregation mediated by subthreshold concentrations of epinephrine (1 micromol/L) and AA (0.2 micromol/L) was inhibited by the alpha2-receptor antagonist (yohimbine, IC50)=0.6 micromol/L) and an inhibitor of AA-cyclooxygenase (COX), indomethacin (IC50=0.25 micromol/L).	Epinephrine	107-118	cytochrome c oxidase subunit 5A	Homo sapiens	260-277
15210061-5	2004	RESULTS: The data show that a synergism in platelet aggregation mediated by subthreshold concentrations of epinephrine (1 micromol/L) and AA (0.2 micromol/L) was inhibited by the alpha2-receptor antagonist (yohimbine, IC50)=0.6 micromol/L) and an inhibitor of AA-cyclooxygenase (COX), indomethacin (IC50=0.25 micromol/L).	Epinephrine	107-118	cytochrome c oxidase subunit 5A	Homo sapiens	279-282
15210061-8	2004	CONCLUSION: These data suggest that synergism between epinephrine and AA in platelet aggregation is triggered through receptors coupled to G-protein, which in turn, activate PLC, COX, and MAP kinase-signaling pathways.	Epinephrine	54-65	cytochrome c oxidase subunit 5A	Homo sapiens	179-182
14749208-9	2004	HSL activity was not increased from resting rates during exercise in either trial despite elevated plasma epinephrine, decreased plasma insulin, and increased ERK1/2 phosphorylation.	Epinephrine	106-117	lipase E, hormone sensitive type	Homo sapiens	0-3
15130921-6	2004	A cell-permeable peptide comprising the carboxy-terminal part of the Ral protein reduced both thrombin-induced and epinephrine-induced vWF secretion supporting a crucial role for Ral in this process.	Epinephrine	115-126	von Willebrand factor	Homo sapiens	135-138
15130921-6	2004	A cell-permeable peptide comprising the carboxy-terminal part of the Ral protein reduced both thrombin-induced and epinephrine-induced vWF secretion supporting a crucial role for Ral in this process.	Epinephrine	115-126	RAS like proto-oncogene A	Homo sapiens	179-182
15130921-7	2004	Furthermore, inhibition of protein kinase A by H-89 resulted in a marked reduction of vWF release and greatly diminished levels of GTP-Ral on stimulation with epinephrine.	Epinephrine	159-170	RAS like proto-oncogene A	Homo sapiens	135-138
15027894-7	2004	Fibrinogen was higher in men with high adrenaline (F(7,631)=5.68, P=0.018; where the subscripted value represents the degrees of freedom) and high noradrenaline (F(7,631)=4.19, P=0.041) compared with men with low excretion of the respective hormones.	Epinephrine	39-49	fibrinogen beta chain	Homo sapiens	0-10
15196681-3	2004	Results indicated that P300 components were affected by exercise with a temporary increase in amplitude between the 1st and the 2nd hour and an increase in latency after 2 h of exercise concomitant with some hormonal changes, including an increase in cortisol and epinephrine and a decrease in blood glucose.	Epinephrine	264-275	E1A binding protein p300	Homo sapiens	23-27
15213852-6	2004	Furthermore, we show that the inhibitory effect of AR-C69931MX on ERK2 activation induced by 0.1 U/ml thrombin as well as on platelet aggregation can be bypassed by epinephrine (1 and 10 microM), whereas epinephrine alone has no effect.	Epinephrine	165-176	mitogen-activated protein kinase 1	Homo sapiens	66-70
15213852-6	2004	Furthermore, we show that the inhibitory effect of AR-C69931MX on ERK2 activation induced by 0.1 U/ml thrombin as well as on platelet aggregation can be bypassed by epinephrine (1 and 10 microM), whereas epinephrine alone has no effect.	Epinephrine	204-215	mitogen-activated protein kinase 1	Homo sapiens	66-70
15213852-8	2004	In addition, 2-methylthio-ADP as well as epinephrine provoke ERK2 activation at a thrombin concentration that alone has no detectable effect (0.05 U/ml).	Epinephrine	41-52	mitogen-activated protein kinase 1	Homo sapiens	61-65
15213852-8	2004	In addition, 2-methylthio-ADP as well as epinephrine provoke ERK2 activation at a thrombin concentration that alone has no detectable effect (0.05 U/ml).	Epinephrine	41-52	coagulation factor II, thrombin	Homo sapiens	82-90
15213852-11	2004	The inhibition of U46619-induced ERK2 activation and platelet aggregation by AR-C69931MX are also rescued by epinephrine.	Epinephrine	109-120	mitogen-activated protein kinase 1	Homo sapiens	33-37
15126009-1	2004	Adrenaline plays a major role in the maintenance of blood glucose level by promoting glycogenolysis during prolonged exercise predominantly via the beta2 adrenergic receptor (beta2AR).	Epinephrine	0-10	adrenoceptor beta 2	Homo sapiens	148-173
15126009-1	2004	Adrenaline plays a major role in the maintenance of blood glucose level by promoting glycogenolysis during prolonged exercise predominantly via the beta2 adrenergic receptor (beta2AR).	Epinephrine	0-10	adrenoceptor beta 2	Homo sapiens	175-182
15167453-6	2004	Both NPP and bradykinin increased systolic (SBP) and diastolic (DBP) blood pressures, heart rate and plasma adrenaline and noradrenaline concentrations.	Epinephrine	108-118	kininogen 1	Homo sapiens	13-23
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Epinephrine	26-37	interleukin 18	Homo sapiens	128-147
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Epinephrine	26-37	tumor necrosis factor	Homo sapiens	149-182
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Epinephrine	26-37	interferon gamma	Homo sapiens	187-209
15145612-1	2004	Endogenous catecholamine, epinephrine and norepinephrine, and isoproterenol concentration-dependently induced the production of interleukin (IL)-18, tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma, and inhibited that of IL-10 in human peripheral blood mononuclear cells (PBMC).	Epinephrine	26-37	interleukin 10	Homo sapiens	233-238
15145612-6	2004	Epinephrine/norepinephrine/isoproterenol/beta 2-AR agonists increased the production of IL-18 in monocytes, but had no effect on IL-12, TNF-alpha, IFN-gamma and IL-10 production.	Epinephrine	0-11	interleukin 18	Homo sapiens	88-93
15261273-1	2004	Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system.	Epinephrine	124-135	phenylethanolamine N-methyltransferase	Homo sapiens	14-52
15261273-1	2004	Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system.	Epinephrine	124-135	phenylethanolamine N-methyltransferase	Homo sapiens	54-58
15245435-6	2004	beta2-AR stimulation with epinephrine 10(-6) M and salbutamol 10(-6)-10(-5) M yielded a strong cyclic adenosine monophospate (cAMP) response in association with upregulated melanin production.	Epinephrine	26-37	adrenoceptor beta 2	Homo sapiens	0-8
15245435-7	2004	Taken together these results indicate that the biosynthesis and release of epinephrine (10(-6) M) by surrounding keratinocytes can provide the cAMP response leading to melanogenesis in melanocytes via the beta2-AR signal.	Epinephrine	75-86	adrenoceptor beta 2	Homo sapiens	205-213
15130921-5	2004	METHODS AND RESULTS: Activation of Ral was observed 15 to 20 minutes after stimulation of endothelial cells with epinephrine, forskolin, or dibutyryl-cAMP.	Epinephrine	113-124	RAS like proto-oncogene A	Homo sapiens	35-38
15130921-6	2004	A cell-permeable peptide comprising the carboxy-terminal part of the Ral protein reduced both thrombin-induced and epinephrine-induced vWF secretion supporting a crucial role for Ral in this process.	Epinephrine	115-126	RAS like proto-oncogene A	Homo sapiens	69-72
15305248-5	2004	RESULTS: All 3 concentrations of epinephrine produced marked vasoconstriction, both alone and in combination with all 3 doses of the anesthetics ( P &lt;.001 in all cases).	Epinephrine	33-44	paired box 5	Homo sapiens	9-14
15305248-5	2004	RESULTS: All 3 concentrations of epinephrine produced marked vasoconstriction, both alone and in combination with all 3 doses of the anesthetics ( P &lt;.001 in all cases).	Epinephrine	33-44	paired box 5	Homo sapiens	114-119
15093697-7	2004	Central administration of SCP (0.05 or 0.5 nmol) elicited transient increases in mean arterial blood pressure (MABP) and heart rate (HR), and the higher dose of SCP (0.5 nmol) resulted in increased plasma epinephrine.	Epinephrine	205-216	cysteine-rich secretory protein 3	Rattus norvegicus	26-29
15093697-7	2004	Central administration of SCP (0.05 or 0.5 nmol) elicited transient increases in mean arterial blood pressure (MABP) and heart rate (HR), and the higher dose of SCP (0.5 nmol) resulted in increased plasma epinephrine.	Epinephrine	205-216	cysteine-rich secretory protein 3	Rattus norvegicus	161-164
15240394-2	2004	Immobilization (IMMO) stress in rats stimulates epinephrine production in part via the gene encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	48-59	phenylethanolamine-N-methyltransferase	Rattus norvegicus	137-175
15240394-2	2004	Immobilization (IMMO) stress in rats stimulates epinephrine production in part via the gene encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	48-59	phenylethanolamine-N-methyltransferase	Rattus norvegicus	177-181
15240399-3	2004	mRNA levels of the phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing epinephrine synthesis in myocardial tissue, were determined in 18 patients (0 to 10 yr after HTx).	Epinephrine	88-99	phenylethanolamine N-methyltransferase	Homo sapiens	19-57
15240399-3	2004	mRNA levels of the phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing epinephrine synthesis in myocardial tissue, were determined in 18 patients (0 to 10 yr after HTx).	Epinephrine	88-99	phenylethanolamine N-methyltransferase	Homo sapiens	59-63
15240408-7	2004	There is ongoing, continuous release of epinephrine from the heart in panic sufferers, perhaps attributable to epinephrine loading of cardiac sympathetic nerves by uptake from plasma during panic attacks, or possibly to in situ synthesis of epinephrine through the action of intracardiac phenylethanolamine-N-methytransferase (PNMT) activated by repeated cortisol responses.	Epinephrine	40-51	phenylethanolamine N-methyltransferase	Homo sapiens	288-325
15240408-7	2004	There is ongoing, continuous release of epinephrine from the heart in panic sufferers, perhaps attributable to epinephrine loading of cardiac sympathetic nerves by uptake from plasma during panic attacks, or possibly to in situ synthesis of epinephrine through the action of intracardiac phenylethanolamine-N-methytransferase (PNMT) activated by repeated cortisol responses.	Epinephrine	40-51	phenylethanolamine N-methyltransferase	Homo sapiens	327-331
14722032-0	2004	Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity.	Epinephrine	0-11	interleukin 6	Mus musculus	23-27
15044443-10	2004	In myocytes, insulin increased, while epinephrine, isoproterenol, and forskolin reduced musclin mRNA, all of which are known to increase the cellular content of cyclic AMP, a counter-regulator to insulin.	Epinephrine	38-49	osteocrin	Mus musculus	88-95
14722032-6	2004	Epinephrine had a similar effect in C2C12 muscle cells, where the hormone increased IL-6 protein and mRNA in a dose- and time-dependent manner.	Epinephrine	0-11	interleukin 6	Mus musculus	84-88
14722032-7	2004	Epinephrine-stimulated IL-6 expression was attenuated by the alpha-adrenergic receptor antagonist phentolamine and completely blocked by either the beta1/2-adrenergic receptor antagonist propranalol or the beta2-antagonist ICI-118551.	Epinephrine	0-11	interleukin 6	Mus musculus	23-27
14722032-7	2004	Epinephrine-stimulated IL-6 expression was attenuated by the alpha-adrenergic receptor antagonist phentolamine and completely blocked by either the beta1/2-adrenergic receptor antagonist propranalol or the beta2-antagonist ICI-118551.	Epinephrine	0-11	adrenergic receptor, beta 1	Mus musculus	148-175
14722032-7	2004	Epinephrine-stimulated IL-6 expression was attenuated by the alpha-adrenergic receptor antagonist phentolamine and completely blocked by either the beta1/2-adrenergic receptor antagonist propranalol or the beta2-antagonist ICI-118551.	Epinephrine	0-11	hemoglobin, beta adult minor chain	Mus musculus	206-211
14722032-8	2004	The transcriptional inhibitor DRB and the synthetic glucocorticoid dexamethasone also blocked epinephrine-induced IL-6.	Epinephrine	94-105	interleukin 6	Mus musculus	114-118
14722032-9	2004	SP-600125 (a JNK inhibitor) and SB-202190 (a p38 MAP kinase inhibitor) completely blocked epinephrine-induced IL-6 synthesis.	Epinephrine	90-101	mitogen-activated protein kinase 8	Mus musculus	13-16
14722032-9	2004	SP-600125 (a JNK inhibitor) and SB-202190 (a p38 MAP kinase inhibitor) completely blocked epinephrine-induced IL-6 synthesis.	Epinephrine	90-101	mitogen-activated protein kinase 14	Mus musculus	45-48
14722032-9	2004	SP-600125 (a JNK inhibitor) and SB-202190 (a p38 MAP kinase inhibitor) completely blocked epinephrine-induced IL-6 synthesis.	Epinephrine	90-101	interleukin 6	Mus musculus	110-114
14722032-11	2004	Trichostatin A (a histone deacetylase inhibitor) blocked both endotoxin- and epinephrine-induced IL-6 expression.	Epinephrine	77-88	interleukin 6	Mus musculus	97-101
14722032-12	2004	These data suggest that epinephrine induces IL-6 synthesis in skeletal muscle in vivo and myocytes in vitro.	Epinephrine	24-35	interleukin 6	Mus musculus	44-48
15033481-2	2004	Mobilization of fatty acids from this pool is probably regulated by hormone-sensitive lipase (HSL), which has recently been shown to exist in muscle and to be activated by epinephrine via PKA and by contractions via PKC and <protein-id="114509">ERK.	Epinephrine	172-183	lipase E, hormone sensitive type	Rattus norvegicus	68-92
15102946-0	2004	Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.	Epinephrine	54-65	adrenoceptor beta 2	Homo sapiens	102-127
15182743-6	2004	These results indicate that urinary and electrolyte excretion effects induced by adrenaline into the MSA are mediated primarily by PVN AT1 receptors.	Epinephrine	81-91	angiotensin II receptor, type 1a	Rattus norvegicus	135-138
15047018-5	2004	Combined in situ hybridization and immunocytochemistry was performed to study the colocalization of CART and phenylethanolamine N-methyltransferase (PNMT), the synthesizing enzyme of adrenaline, in axons innervating the hypophysiotropic TRH neurons.	Epinephrine	183-193	CART prepropeptide	Homo sapiens	100-104
15047018-5	2004	Combined in situ hybridization and immunocytochemistry was performed to study the colocalization of CART and phenylethanolamine N-methyltransferase (PNMT), the synthesizing enzyme of adrenaline, in axons innervating the hypophysiotropic TRH neurons.	Epinephrine	183-193	phenylethanolamine N-methyltransferase	Homo sapiens	109-147
15047018-5	2004	Combined in situ hybridization and immunocytochemistry was performed to study the colocalization of CART and phenylethanolamine N-methyltransferase (PNMT), the synthesizing enzyme of adrenaline, in axons innervating the hypophysiotropic TRH neurons.	Epinephrine	183-193	phenylethanolamine N-methyltransferase	Homo sapiens	149-153
15126521-3	2004	Metanephrine is formed from epinephrine that leaks from adrenomedullary storage vesicles by catechol-O-methyl transferase (COMT) and is continuously released into the circulation.	Epinephrine	28-39	catechol-O-methyltransferase	Homo sapiens	92-121
15126521-3	2004	Metanephrine is formed from epinephrine that leaks from adrenomedullary storage vesicles by catechol-O-methyl transferase (COMT) and is continuously released into the circulation.	Epinephrine	28-39	catechol-O-methyltransferase	Homo sapiens	123-127
15294048-6	2004	When analysed under conditions optimal for HSL, neutral lipase activity in muscle can be stimulated by adrenaline as well as by contractions.	Epinephrine	103-113	lipase E, hormone sensitive type	Rattus norvegicus	43-46
15294048-6	2004	When analysed under conditions optimal for HSL, neutral lipase activity in muscle can be stimulated by adrenaline as well as by contractions.	Epinephrine	103-113	lipase G, endothelial type	Rattus norvegicus	56-62
15294048-9	2004	The immunoreactive HSL in muscle is stimulated by adrenaline via beta-adrenergic activation of cAMP-dependent protein kinase (PKA).	Epinephrine	50-60	lipase E, hormone sensitive type	Rattus norvegicus	19-22
15294048-17	2004	In line with the view that the two stimuli act by different mechanisms, training increases contraction-mediated HSL activation but diminishes adrenaline-mediated HSL activation in muscle.	Epinephrine	142-152	lipase E, hormone sensitive type	Rattus norvegicus	162-165
15294048-18	2004	In conclusion, HSL is present in skeletal muscle and can be activated by phosphorylation in response to both adrenaline and muscle contractions.	Epinephrine	109-119	lipase E, hormone sensitive type	Rattus norvegicus	15-18
15294048-19	2004	Training increases contraction-mediated HSL activation, but decreases adrenaline-mediated HSL activation in muscle.	Epinephrine	70-80	lipase E, hormone sensitive type	Rattus norvegicus	90-93
15294049-2	2004	A series of studies designed to characterise the response of HSL to three stimuli: exercise of varying intensities and durations; adrenaline infusions; altered fuel supply have recently been conducted in human skeletal muscle.	Epinephrine	130-140	lipase E, hormone sensitive type	Homo sapiens	61-64
15294049-5	2004	The combination of low adrenaline and Ca(2+) levels and resting levels of insulin appear to dictate the level of HSL activity at rest.	Epinephrine	23-33	lipase E, hormone sensitive type	Homo sapiens	113-116
15294049-7	2004	During intense aerobic exercise, adrenaline may contribute to the early activation of HSL.	Epinephrine	33-43	lipase E, hormone sensitive type	Homo sapiens	86-89
15033481-2	2004	Mobilization of fatty acids from this pool is probably regulated by hormone-sensitive lipase (HSL), which has recently been shown to exist in muscle and to be activated by epinephrine via PKA and by contractions via PKC and <protein-id="114509">ERK.	Epinephrine	172-183	lipase E, hormone sensitive type	Rattus norvegicus	94-97
15090041-4	2004	The hindbrain NPY innervation of the hypothalamus is derived from cell bodies that coexpress norepinephrine or epinephrine.	Epinephrine	96-107	neuropeptide Y	Rattus norvegicus	14-17
15131912-4	2004	Vasopressin, like epinephrine, promotes selective but potent vasoconstriction of smooth muscle, but unlike epinephrine, without the potentially harmful side effects of increasing myocardial workload, therefore increasing oxygen demand and subsequent worsening of cardiac function.	Epinephrine	18-29	arginine vasopressin	Homo sapiens	0-11
15030373-16	2004	After haemorrhage, endothelin-1 seems to facilitate adrenaline release and to blunt noradrenaline release.	Epinephrine	52-62	endothelin 1	Canis lupus familiaris	19-31
15065080-4	2004	In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration-dependent manner, with an IC(50) value of about 27.6 microM.	Epinephrine	94-104	DEAD-box helicase 46	Homo sapiens	18-24
15182418-3	2004	The short-term responses include enhancement of the respiratory and cardiac functions, adrenaline secretion from adrenal medullary cells, and pulmonary vasoconstriction, whereas the long-term response is the increase in erythropoietin production with the consequent increase in red blood cells.	Epinephrine	87-97	erythropoietin	Homo sapiens	220-234
14984413-3	2004	We found that the intradermal injection of peptide fragments of domains of laminin and fibronectin important for adhesive signaling selectively inhibited the hyperalgesia caused by prostaglandin E2 (PGE2) and epinephrine (EPI), respectively.	Epinephrine	209-220	fibronectin 1	Rattus norvegicus	87-98
15023079-3	2004	In the present study, PWR has been used to monitor the incorporation of the human beta(2)-adrenergic receptor into a solid-supported egg phosphatidylcholine lipid bilayer and to follow the binding of full agonists (isoproterenol, epinephrine), a partial agonist (dobutamine), an antagonist (alprenolol), and an inverse agonist (ICI-118,551) to the receptor.	Epinephrine	230-241	adrenoceptor beta 2	Homo sapiens	82-109
14613926-4	2004	Epinephrine hyperpolarizes Sur1KO beta-cells, inhibiting their spontaneous action potentials.	Epinephrine	0-11	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	27-31
15137481-0	2004	[A notice for use for patients who benifit from an adrenaline pen.	Epinephrine	51-61	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	62-65
14981238-2	2004	To validate this structure, we use the HierDock first principles method to predict the ligand-binding sites for epinephrine and norepinephrine and for eight other ligands, including agonists and antagonists to beta 2 AR and ligands not observed to bind to beta 2 AR.	Epinephrine	112-123	adrenoceptor beta 2	Homo sapiens	256-265
14715701-5	2004	Epinephrine and norepinephrine up-regulated MMP-1 and potentiated LPS-induced expression of MMP-1 in peripheral blood monocytes and monocyte-derived macrophages.	Epinephrine	0-11	matrix metallopeptidase 1	Homo sapiens	44-49
14715701-5	2004	Epinephrine and norepinephrine up-regulated MMP-1 and potentiated LPS-induced expression of MMP-1 in peripheral blood monocytes and monocyte-derived macrophages.	Epinephrine	0-11	matrix metallopeptidase 1	Homo sapiens	92-97
14984413-3	2004	We found that the intradermal injection of peptide fragments of domains of laminin and fibronectin important for adhesive signaling selectively inhibited the hyperalgesia caused by prostaglandin E2 (PGE2) and epinephrine (EPI), respectively.	Epinephrine	222-225	fibronectin 1	Rattus norvegicus	87-98
14706855-4	2004	AR-C69931MX (10 microM) inhibition was overcome by epinephrine (1 microM), an agonist of the Gi-coupled alpha(2A)-adrenergic receptor, suggesting that the Gi-coupled receptor was necessary for ERK2 activation by collagen.	Epinephrine	51-62	mitogen-activated protein kinase 1	Homo sapiens	193-197
14602724-9	2004	Epinephrine, a known platelet sensitizer and antagonist of insulin, abolishes the effect of insulin on [Ca(2+)](i), tyrosine phosphorylation of G(i)alpha(2), and aggregation by interfering with the phosphorylation of the insulin receptor beta subunit.	Epinephrine	0-11	insulin	Homo sapiens	92-99
14602724-9	2004	Epinephrine, a known platelet sensitizer and antagonist of insulin, abolishes the effect of insulin on [Ca(2+)](i), tyrosine phosphorylation of G(i)alpha(2), and aggregation by interfering with the phosphorylation of the insulin receptor beta subunit.	Epinephrine	0-11	insulin	Homo sapiens	59-66
14602724-9	2004	Epinephrine, a known platelet sensitizer and antagonist of insulin, abolishes the effect of insulin on [Ca(2+)](i), tyrosine phosphorylation of G(i)alpha(2), and aggregation by interfering with the phosphorylation of the insulin receptor beta subunit.	Epinephrine	0-11	insulin	Homo sapiens	92-99
14711909-8	2004	Among patients with asystole, however, vasopressin use was associated with significantly higher rates of hospital admission (29.0 percent, vs. 20.3 percent in the epinephrine group; P=0.02) and hospital discharge (4.7 percent vs. 1.5 percent, P=0.04).	Epinephrine	163-174	arginine vasopressin	Homo sapiens	39-50
14711909-9	2004	Among 732 patients in whom spontaneous circulation was not restored with the two injections of the study drug, additional treatment with epinephrine resulted in significant improvement in the rates of survival to hospital admission and hospital discharge in the vasopressin group, but not in the epinephrine group (hospital admission rate, 25.7 percent vs. 16.4 percent; P=0.002; hospital discharge rate, 6.2 percent vs. 1.7 percent; P=0.002).	Epinephrine	137-148	arginine vasopressin	Homo sapiens	262-273
14667941-0	2004	Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation.	Epinephrine	105-115	phospholipase A2 group IB	Homo sapiens	131-147
14667941-5	2004	The inhibitory effect of adrenaline runs in parallel with an increase in intracellular levels of cAMP which was reversed by the protein kinase A (PKA) inhibitor H-89, suggesting a role for PKA in mediating the inhibitory effect of adrenaline on fMLP-induced superoxide production.	Epinephrine	25-35	formyl peptide receptor 1	Homo sapiens	245-249
14667941-5	2004	The inhibitory effect of adrenaline runs in parallel with an increase in intracellular levels of cAMP which was reversed by the protein kinase A (PKA) inhibitor H-89, suggesting a role for PKA in mediating the inhibitory effect of adrenaline on fMLP-induced superoxide production.	Epinephrine	231-241	formyl peptide receptor 1	Homo sapiens	245-249
14667941-4	2004	Using the superoxide dismutase (SOD)-inhibitable cytochrome c reduction assay, we report here that the beta-adrenergic agonist, adrenaline at physiologic concentrations (5-100 nM) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated but not phorbol-myristate-acetate (PMA)-stimulated PMN superoxide anion production.	Epinephrine	128-138	cytochrome c, somatic	Homo sapiens	49-61
14667941-7	2004	However, adrenaline strongly depressed the activity of the cytosolic isoform of Phospholipase A(2) (cPLA(2)).	Epinephrine	9-19	phospholipase A2 group IB	Homo sapiens	80-98
14667941-7	2004	However, adrenaline strongly depressed the activity of the cytosolic isoform of Phospholipase A(2) (cPLA(2)).	Epinephrine	9-19	phospholipase A2 group IVA	Homo sapiens	100-107
14667941-8	2004	We suggest that adrenaline inhibits fMLP induced superoxide production upstream of the NADPH oxidase via a mechanism involving PKA and cPLA(2).	Epinephrine	16-26	formyl peptide receptor 1	Homo sapiens	36-40
14667941-8	2004	We suggest that adrenaline inhibits fMLP induced superoxide production upstream of the NADPH oxidase via a mechanism involving PKA and cPLA(2).	Epinephrine	16-26	phospholipase A2 group IVA	Homo sapiens	135-142
14667941-4	2004	Using the superoxide dismutase (SOD)-inhibitable cytochrome c reduction assay, we report here that the beta-adrenergic agonist, adrenaline at physiologic concentrations (5-100 nM) inhibited formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated but not phorbol-myristate-acetate (PMA)-stimulated PMN superoxide anion production.	Epinephrine	128-138	formyl peptide receptor 1	Homo sapiens	229-233
15259379-6	2004	BNP was positively related to age, NYHA class, IL-6, TNF-alpha, adrenaline, noradrenaline and cortisol, while negatively with ejection fraction and FT3.	Epinephrine	64-74	natriuretic peptide B	Homo sapiens	0-3
15319543-10	2004	Indeed, epinephrine translocated PKC or cPLA2 from cytosol to membrane fraction.	Epinephrine	8-19	cytosolic phospholipase A2	Oryctolagus cuniculus	40-45
15319543-11	2004	In conclusion, epinephrine partially inhibits the alpha-MG uptake through PKA, PKC, p44/42, p38 MAPK, and cPLA2 pathways in the PTCs.	Epinephrine	15-26	cytosolic phospholipase A2	Oryctolagus cuniculus	106-111
15249727-6	2004	RESULTS: Infusion of epinephrine did not affect lethality of septic mice but induced alterations of splenocyte apoptosis, splenocyte proliferation and IL-2 release and was associated with profound changes of circulating immune cell subpopulations.	Epinephrine	21-32	interleukin 2	Mus musculus	151-155
14964578-8	2004	The levels of CSF IL-6 and IFN-gamma in patients with non-herpetic ALE were significantly lower than those in patients with HSE (p<0.05 and p<0.01, respectively).	Epinephrine	67-70	interleukin 6	Homo sapiens	18-22
14964578-8	2004	The levels of CSF IL-6 and IFN-gamma in patients with non-herpetic ALE were significantly lower than those in patients with HSE (p<0.05 and p<0.01, respectively).	Epinephrine	67-70	interferon gamma	Homo sapiens	27-36
14964578-12	2004	The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection.	Epinephrine	74-77	interleukin 6	Homo sapiens	14-18
14964578-12	2004	The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection.	Epinephrine	74-77	interferon gamma	Homo sapiens	23-32
14964578-12	2004	The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection.	Epinephrine	197-200	interleukin 6	Homo sapiens	14-18
14964578-12	2004	The levels of IL-6 and IFN-gamma in the CSF of patients with non-herpetic ALE were significantly lower than those of patients with HSE, possibly reflecting an immunological process in this type of ALE rather than direct viral infection.	Epinephrine	197-200	interferon gamma	Homo sapiens	23-32
15050094-12	2004	Since there exists a close relationship between epinephrine and DHEA-S levels during adrenarche which shows modulatory interactions between adrenal androgen production and adrenomedullary function, we suggest again that adrenomedullary function might play a role in the control of fetal adrenal androgen secretion.	Epinephrine	48-59	sulfotransferase family 2A member 1	Homo sapiens	64-70
14722251-5	2004	Epinephrine, prostaglandin E1, and forskolin at maximum concentrations stimulated phosphorylation of the beta2AR PKA site (Ser262) by 4-fold, whereas PMA stimulated it by 2-fold.	Epinephrine	0-11	adrenoceptor beta 2	Homo sapiens	105-112
15249727-9	2004	Coadministration of propranolol and epinephrine augmented the propranolol-induced changes of splenocyte apoptosis and IL-6 release and was associated with the highest mortality of septic mice.	Epinephrine	36-47	interleukin 6	Mus musculus	118-122
14729151-3	2003	(i) Serosal application of isoproterenol (log(10)EC50=-7.1+/0.2; Hill coefficient=1.1+/0.2), as well as nor-adrenaline, activated an anion pathway with an apical selectivity sequence, G(Cl)&gt;G(Br)&gt; or =G(NO(3))&gt;G(I), comparable to the published selectivity sequence of cloned human CFTR expressed in Xenopus oocytes.	Epinephrine	108-118	CF transmembrane conductance regulator	Homo sapiens	290-294
15545008-9	2004	In the rat brain, the most prominent observation was the revelation of all catecholamine cells (dopamine, norepinephrine, epinephrine) by the flotillin-1 antibody (1:100 dilution).	Epinephrine	109-120	flotillin 1	Rattus norvegicus	142-153
14688680-3	2003	The purpose of this study was to elucidate potential mechanisms underlying the hyperoxic-induced hyperglycemia by examining glucagon, insulin, and epinephrine, which are important in glucose regulation and skeletal and cardiac glucose transporters (GLUT1 and GLUT4), which facilitate glucose entry.	Epinephrine	147-158	solute carrier family 2 member 1	Homo sapiens	249-254
14675082-6	2003	Treatment of cells with agonists of platelet activation (ADP, epinephrine, and thrombin receptor-activating peptide) resulted in the release of VWF antigen and active FVIII into the supernatant from transduced cells.	Epinephrine	62-73	von Willebrand factor	Homo sapiens	144-147
14675082-6	2003	Treatment of cells with agonists of platelet activation (ADP, epinephrine, and thrombin receptor-activating peptide) resulted in the release of VWF antigen and active FVIII into the supernatant from transduced cells.	Epinephrine	62-73	coagulation factor VIII	Homo sapiens	167-172
14625484-5	2003	Animals, receiving epinephrine therapy, showed a significantly prolonged upregulation of IL-6 mRNA expression at 4 h after LPS application in liver (P = 0.0014), spleen (P &lt; 0.0001), and mesenteric lymph nodes (P = 0.0078) as compared with animals treated with norepinephrine or fluid resuscitation.	Epinephrine	19-30	interleukin 6	Homo sapiens	89-93
14625484-0	2003	Continuous therapeutic epinephrine but not norepinephrine prolongs splanchnic IL-6 production in porcine endotoxic shock.	Epinephrine	23-34	interleukin 6	Homo sapiens	78-82
14625484-8	2003	The peak of serum tumor necrosis factor alpha at 1 h after LPS application was already significantly reduced by epinephrine, which was only administered at a mean of less than 0.05 microg/kg/min at this time point (P &lt; 0.01).	Epinephrine	112-123	tumor necrosis factor	Homo sapiens	18-45
14625484-10	2003	Our data suggest that the therapeutic application of epinephrine but not of norepinephrine is associated with a profound effect on the IL-6 response of splanchnic reticuloendothelial tissues.	Epinephrine	53-64	interleukin 6	Homo sapiens	135-139
14504133-3	2003	TRA-418 inhibited platelet GPIIb/IIIa activation as well as P-selectin expression induced by adenosine 5"-diphosphate, thrombin receptor agonist peptide 1-6 (Ser-Phe-Leu-Leu-Arg-Asn-NH2), and U-46619 in the presence of epinephrine (U-46619+ epinephrine).	Epinephrine	219-230	T cell receptor alpha locus	Homo sapiens	0-3
14504133-3	2003	TRA-418 inhibited platelet GPIIb/IIIa activation as well as P-selectin expression induced by adenosine 5"-diphosphate, thrombin receptor agonist peptide 1-6 (Ser-Phe-Leu-Leu-Arg-Asn-NH2), and U-46619 in the presence of epinephrine (U-46619+ epinephrine).	Epinephrine	241-252	T cell receptor alpha locus	Homo sapiens	0-3
14504133-5	2003	The TP-receptor antagonist SQ-29548 inhibited only U-46619+epinephrine-induced GPIIb/IIIa activation, P-selectin expression, and platelet aggregation.	Epinephrine	59-70	integrin subunit alpha 2b	Homo sapiens	79-84
14606874-5	2003	Epinephrine was found to affect Fbg conformation and to increase platelet adhesion to PE at stress level.	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	32-35
14606874-8	2003	The response of platelets was affected by the stress status of donors through the influence of epinephrine on Fbg conformation.	Epinephrine	95-106	fibrinogen beta chain	Homo sapiens	110-113
14621188-7	2003	Plasma epinephrine concentrations after ICV administration of 10 nmol urotensin II were 203 +/- 58 pmol/ml in SHR and 227 +/- 47 pmol/ml in WKY, which tended to be higher than those in artificial cerebrospinal fluid-injected rats (73+/- 7 and 87 +/- 28 pmol/ml, respectively, p &lt; 0.1).	Epinephrine	7-18	urotensin 2	Rattus norvegicus	70-82
14676386-5	2003	Adrenaline and cortisone doses dependently suppressed CD69 expression on NK cells.	Epinephrine	0-10	CD69 molecule	Homo sapiens	54-58
14514350-1	2003	OBJECTIVE: Adrenaline inhibits insulin secretion through activation of alpha(2)-adrenoceptors (ARs).	Epinephrine	11-21	adrenergic receptor, alpha 2b	Mus musculus	71-93
14517799-7	2003	Furthermore, the glucagon response to epinephrine in isolated perifused islets was moderately impaired in gastrin -/- versus gastrin +/+ islets (40% reduction; P &lt; 0.01, gastrin +/+ vs. gastrin -/- mice).	Epinephrine	38-49	gastrin	Mus musculus	106-113
14517799-7	2003	Furthermore, the glucagon response to epinephrine in isolated perifused islets was moderately impaired in gastrin -/- versus gastrin +/+ islets (40% reduction; P &lt; 0.01, gastrin +/+ vs. gastrin -/- mice).	Epinephrine	38-49	gastrin	Mus musculus	125-132
14517799-7	2003	Furthermore, the glucagon response to epinephrine in isolated perifused islets was moderately impaired in gastrin -/- versus gastrin +/+ islets (40% reduction; P &lt; 0.01, gastrin +/+ vs. gastrin -/- mice).	Epinephrine	38-49	gastrin	Mus musculus	125-132
14517799-7	2003	Furthermore, the glucagon response to epinephrine in isolated perifused islets was moderately impaired in gastrin -/- versus gastrin +/+ islets (40% reduction; P &lt; 0.01, gastrin +/+ vs. gastrin -/- mice).	Epinephrine	38-49	gastrin	Mus musculus	125-132
12900381-8	2003	The results demonstrate that, in situ, insulin counteracts the epinephrine-induced lipolysis in adipose tissue.	Epinephrine	63-74	insulin	Homo sapiens	39-46
12963416-6	2003	In the presence of eserine (another acetylcholinesterase inhibitor), endogenous acetylcholine-induced epinephrine release was also inhibited by atropine.	Epinephrine	102-113	acetylcholinesterase	Rattus norvegicus	36-56
12904199-4	2003	We observed a rise in blood pressure (BP) after insulin was given and the BP was subsequently responsive to epinephrine.	Epinephrine	108-119	insulin	Homo sapiens	48-55
14514739-4	2003	Univariate analysis revealed that plasma NPY was directly related to plasma norepinephrine (r = 0.37, P &lt; 0.001) and epinephrine (r = 0.17, P = 0.005), exceeding the upper limit of the normal range in the majority of patients with end-stage renal disease (170 of 277, 61%).	Epinephrine	79-90	neuropeptide Y	Homo sapiens	41-44
14519412-7	2003	administered CRH increased plasma noradrenaline and adrenaline in a dose-dependent manner (0.5, 1.5, and 3.0 nmol/animal).	Epinephrine	37-47	corticotropin releasing hormone	Rattus norvegicus	13-16
12900383-1	2003	Previously, we demonstrated that epinephrine induced the expression of interleukin (IL)-6 mRNA via beta-adrenoceptors in cultured human osteoblastic cells.	Epinephrine	33-44	interleukin 6	Homo sapiens	71-89
12766260-7	2003	Similar findings were obtained when the hearts were challenged with either epinephrine or isoproterenol (0.1 microM each), thereby suggesting that sympathetic stimulation drives the long QT phenotype in Kcnq1-deficient hearts.	Epinephrine	75-86	potassium voltage-gated channel, subfamily Q, member 1	Mus musculus	203-208
12925276-1	2003	Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.	Epinephrine	32-43	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	115-131
14501155-7	2003	These results suggest that clomipramine induces hyperglycemia in mice by blocking the 5-HT(2B )and/or 5-HT(2C) receptors, which results in facilitation of adrenaline release.	Epinephrine	155-165	5-hydroxytryptamine (serotonin) receptor 2B	Mus musculus	86-93
12885791-0	2003	Urotensin II acts centrally to increase epinephrine and ACTH release and cause potent inotropic and chronotropic actions.	Epinephrine	40-51	urotensin 2	Homo sapiens	0-12
12925276-1	2003	Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.	Epinephrine	32-43	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	133-136
12925276-1	2003	Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.	Epinephrine	32-43	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	172-175
12925276-1	2003	Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.	Epinephrine	32-43	protein kinase C, epsilon	Rattus norvegicus	177-201
12925276-1	2003	Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.	Epinephrine	32-43	protein kinase C, epsilon	Rattus norvegicus	203-213
12925276-1	2003	Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.	Epinephrine	32-43	Eph receptor B1	Rattus norvegicus	220-257
12925276-1	2003	Prostaglandin E(2) (PGE(2)) and epinephrine act directly on nociceptors to produce mechanical hyperalgesia through protein kinase A (PKA) alone or through a combination of PKA, protein kinase C epsilon (PKCepsilon), and extracellular signal-regulated kinase (ERK), respectively.	Epinephrine	32-43	Eph receptor B1	Rattus norvegicus	259-262
12890576-3	2003	This effect of adrenaline was inhibited by amiloride or EIPA, indicating that adrenaline stimulated NHE 1.	Epinephrine	15-25	solute carrier family 9 member A1	Homo sapiens	100-105
12864745-6	2003	Analysed under conditions optimal for HSL, neutral lipase activity in muscle can be stimulated by adrenaline as well as by contractions.	Epinephrine	98-108	lipase E, hormone sensitive type	Homo sapiens	38-41
12864745-9	2003	The immunoreactive HSL in muscle is stimulated by adrenaline via beta-adrenergic activation of protein kinase A (PKA).	Epinephrine	50-60	lipase E, hormone sensitive type	Homo sapiens	19-22
12864745-17	2003	In line with the view that the two stimuli act by different mechanisms, training increases the contraction-mediated, but diminishes the adrenaline mediated HSL activation in muscle.	Epinephrine	136-146	lipase E, hormone sensitive type	Homo sapiens	156-159
12871047-9	2003	Physiological substrates for EMT include the monoamines serotonin, dopamine, noradrenaline, adrenaline and histamine.	Epinephrine	80-90	solute carrier family 22 member 3	Homo sapiens	29-32
12871990-7	2003	In the adrenal medulla, double IHC labeling showed that EM66-IR occurs exclusively in epinephrine-synthesizing cells.	Epinephrine	86-97	secretogranin II	Homo sapiens	56-60
12890576-2	2003	Adrenaline increased both intracellular pH (pHi) and Na(+) influx in erythrocyte suspensions.	Epinephrine	0-10	glucose-6-phosphate isomerase	Homo sapiens	44-47
12794177-2	2003	The mobilization of fatty acids from this pool is probably regulated by hormone-sensitive lipase (HSL), which has recently been shown to exist in muscle and to be activated by both adrenaline and contractions.	Epinephrine	181-191	lipase E, hormone sensitive type	Rattus norvegicus	98-101
12764077-1	2003	In the adrenergic system, release of the neurotransmitter norepinephrine from sympathetic nerves is regulated by presynaptic inhibitory alpha2-adrenoceptors, but it is unknown whether release of epinephrine from the adrenal gland is controlled by a similar short feedback loop.	Epinephrine	61-72	adrenergic receptor, alpha 2a	Mus musculus	136-156
12890576-1	2003	The effect of adrenaline on normal and obese human Na(+)-H(+) antiport (NHE 1) erythrocyte activity has been studied.	Epinephrine	14-24	solute carrier family 9 member A1	Homo sapiens	72-77
12890576-3	2003	This effect of adrenaline was inhibited by amiloride or EIPA, indicating that adrenaline stimulated NHE 1.	Epinephrine	78-88	solute carrier family 9 member A1	Homo sapiens	100-105
12890576-4	2003	Phorbol myristicate ester (PMA), a protein kinase C (PKC) stimulator, increased the activity of NHE 1 whereas calphostin C, a PKC inhibitor, partially inhibited NHE 1 activation induced by adrenaline.	Epinephrine	189-199	solute carrier family 9 member A1	Homo sapiens	96-101
12890576-4	2003	Phorbol myristicate ester (PMA), a protein kinase C (PKC) stimulator, increased the activity of NHE 1 whereas calphostin C, a PKC inhibitor, partially inhibited NHE 1 activation induced by adrenaline.	Epinephrine	189-199	solute carrier family 9 member A1	Homo sapiens	161-166
12890576-5	2003	The effect of adrenaline to NHE 1 was counteracted by prazocin and by propranolol as well indicating the involvement of both alpha and beta 2 adrenergic receptors.	Epinephrine	14-24	solute carrier family 9 member A1	Homo sapiens	28-33
12890576-6	2003	The effect of adrenaline on erythrocyte NHE 1 activity was significantly more profound in obese compared to normal subjects.	Epinephrine	14-24	solute carrier family 9 member A1	Homo sapiens	40-45
12890576-7	2003	These data indicate that adrenaline induces an increase of pHi and Na(+) uptake of human erythrocytes through stimulation of NHE 1 activity.	Epinephrine	25-35	glucose-6-phosphate isomerase	Homo sapiens	59-62
12890576-7	2003	These data indicate that adrenaline induces an increase of pHi and Na(+) uptake of human erythrocytes through stimulation of NHE 1 activity.	Epinephrine	25-35	solute carrier family 9 member A1	Homo sapiens	125-130
12890576-8	2003	The significantly more profound stimulation of NHE 1 activity by adrenaline in obese as compared to normal subjects is discussed.	Epinephrine	65-75	solute carrier family 9 member A1	Homo sapiens	47-52
12754374-4	2003	Acute administration of adrenaline or noradrenaline increased mPer1 but not mPer2 expression in the liver of mice in vivo and in hepatic slices in vitro.	Epinephrine	24-34	period circadian clock 1	Mus musculus	62-67
12897373-8	2003	In parallel, insulin-induced Akt phosphorylation was reduced in both tissues of epinephrine-treated rats, and in liver but not in muscle of dexamethasonetreated rats.	Epinephrine	80-91	AKT serine/threonine kinase 1	Rattus norvegicus	29-32
12897373-9	2003	The reduction in insulin-induced Akt phosphorylation may help to explain the insulin resistance in liver and muscle of epinephrine-treated rats and in the liver of dexamethasone-treated rats.	Epinephrine	119-130	AKT serine/threonine kinase 1	Rattus norvegicus	33-36
12611761-11	2003	The increased HSL activity at 60 min was associated with the stimulating effect of increased epinephrine and decreased insulin levels.	Epinephrine	93-104	lipase E, hormone sensitive type	Homo sapiens	14-17
12730334-0	2003	Effects of plasma adrenaline on hormone-sensitive lipase at rest and during moderate exercise in human skeletal muscle.	Epinephrine	18-28	lipase E, hormone sensitive type	Homo sapiens	32-56
12730334-1	2003	We investigated the effect of increased plasma adrenaline on hormone-sensitive lipase (HSL) activity and extracellular regulated kinase (ERK) 1/2 phosphorylation during exercise.	Epinephrine	47-57	lipase E, hormone sensitive type	Homo sapiens	61-85
12730334-4	2003	Exogenous adrenaline infusion increased (P &lt; 0.05) plasma adrenaline at rest during ADR, which resulted in greater HSL activity (Pre, 2.14 +/- 0.10 mmol min-1 (kg dry matter (dm))-1; 0 min, 2.74 +/- 0.20 mmol min-1 (kg dm)-1).	Epinephrine	10-20	lipase E, hormone sensitive type	Homo sapiens	118-121
12730334-4	2003	Exogenous adrenaline infusion increased (P &lt; 0.05) plasma adrenaline at rest during ADR, which resulted in greater HSL activity (Pre, 2.14 +/- 0.10 mmol min-1 (kg dry matter (dm))-1; 0 min, 2.74 +/- 0.20 mmol min-1 (kg dm)-1).	Epinephrine	61-71	lipase E, hormone sensitive type	Homo sapiens	118-121
12730334-7	2003	The infusion of exogenous adrenaline at 3 min of exercise in EX+ADR resulted in a marked elevation in plasma adrenaline levels (3 min, 0.57 +/- 0.12 nM; 10 min, 10.08 +/- 0.84 nM) and increased HSL activity by 25 %.	Epinephrine	26-36	lipase E, hormone sensitive type	Homo sapiens	194-197
12761006-6	2003	Neurologic evaluation 24 h after successful resuscitation revealed only an unsteady gait and was normal 5 days after the experiment in all vasopressin/epinephrine-treated animals.	Epinephrine	151-162	vasopressin	Sus scrofa	139-150
12766131-7	2003	In insulin-deficient diabetes (exogenous) insulin levels do not decrease as glucose levels fall, and the combination of deficient glucagon and epinephrine responses causes defective glucose counterregulation.	Epinephrine	143-154	insulin	Homo sapiens	3-10
12746281-7	2003	Furthermore, LV contractility after exogenous epinephrine infusion was also reduced in GLP-1R(-/-) mice.	Epinephrine	46-57	glucagon-like peptide 1 receptor	Mus musculus	87-93
12766202-3	2003	Acetylcholine and epinephrine induced increases in AQP5 levels in the apical plasma membranes of both young adult and senescent rats.	Epinephrine	18-29	aquaporin 5	Rattus norvegicus	51-55
12649300-5	2003	The capacity of the dexefaroxan analogs to antagonize the (-)-epinephrine-mediated [35S]GTP gamma S binding response at a G alpha oCys351Ile protein was inversely correlated with their magnitude of intrinsic activity and unrelated to their ligand binding affinity for the alpha 2A AR.	Epinephrine	58-73	adrenoceptor alpha 2A	Homo sapiens	272-283
12787259-2	2003	The soluble form of COMT (S-COMT) in erythrocytes was endowed with the same affinity as liver S-COMT for the substrate adrenaline.	Epinephrine	119-129	catechol-O-methyltransferase	Rattus norvegicus	20-24
12787259-2	2003	The soluble form of COMT (S-COMT) in erythrocytes was endowed with the same affinity as liver S-COMT for the substrate adrenaline.	Epinephrine	119-129	catechol-O-methyltransferase	Rattus norvegicus	26-32
12847066-1	2003	BACKGROUND: This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (Ang II)-evoked neural release of norepinephrine (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced mitral regurgitation (MR) in the dog.	Epinephrine	146-157	adrenoceptor beta 1	Canis lupus familiaris	50-70
12847066-1	2003	BACKGROUND: This study tested the hypothesis that beta1-adrenoreceptor blockade modulates the angiotensin II (Ang II)-evoked neural release of norepinephrine (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced mitral regurgitation (MR) in the dog.	Epinephrine	146-157	ANG	Canis lupus familiaris	110-113
12730078-0	2003	Epinephrine promotes pulmonary angiitis: evidence for a beta1-adrenoreceptor-mediated mechanism.	Epinephrine	0-11	adrenergic receptor, beta 1	Mus musculus	56-76
12887669-1	2003	There has been a marked increase in community concerns of the risk of food induced anaphylaxis in children and a consequent increase in the provision of the self or carer injectable epinephrine (EpiPen) (CSL Ltd, Parkville, Victoria, Australia)).	Epinephrine	182-193	chorionic somatomammotropin hormone like 1	Homo sapiens	204-207
12906031-10	2003	Beta-endorphin and epinephrine only significantly increased in groups 1 and 2 (beta-endorphin; from 7.3 +/- 3.3 pg/mL to 19.9 +/- 17.7 pg/mL, in group 1, P &lt; 0.05; from 7.3 +/- 2.9 to 16.5 +/- 10.7 pg/mL, in group 2, P &lt; 0.05; epinephrine; from 42 +/- 58 pg/mL to 157 +/- 161 pg/mL, in group 1, P &lt; 0.05: from 33 +/- 25 to 202 +/- 252 pg/mL, in group 2, P &lt; 0.05), but not in groups 3 and 4.	Epinephrine	19-30	proopiomelanocortin	Homo sapiens	79-93
12906031-10	2003	Beta-endorphin and epinephrine only significantly increased in groups 1 and 2 (beta-endorphin; from 7.3 +/- 3.3 pg/mL to 19.9 +/- 17.7 pg/mL, in group 1, P &lt; 0.05; from 7.3 +/- 2.9 to 16.5 +/- 10.7 pg/mL, in group 2, P &lt; 0.05; epinephrine; from 42 +/- 58 pg/mL to 157 +/- 161 pg/mL, in group 1, P &lt; 0.05: from 33 +/- 25 to 202 +/- 252 pg/mL, in group 2, P &lt; 0.05), but not in groups 3 and 4.	Epinephrine	233-244	proopiomelanocortin	Homo sapiens	79-93
12718440-3	2003	One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepinephrine and epinephrine, neurohormones in endocrine and nervous tissue.	Epinephrine	86-97	dopamine beta hydroxylase	Mus musculus	18-43
12718440-3	2003	One cuproprotein, dopamine beta-hydroxylase (DBH) functions in the biosynthesis of norepinephrine and epinephrine, neurohormones in endocrine and nervous tissue.	Epinephrine	86-97	dopamine beta hydroxylase	Mus musculus	45-48
12787259-2	2003	The soluble form of COMT (S-COMT) in erythrocytes was endowed with the same affinity as liver S-COMT for the substrate adrenaline.	Epinephrine	119-129	catechol-O-methyltransferase	Rattus norvegicus	94-100
12754374-5	2003	Electrical stimulation of the sympathetic nerves or adrenaline injection caused an elevation of bioluminescence in the liver area of transgenic mice carrying mPer1 promoter-luciferase.	Epinephrine	52-62	period circadian clock 1	Mus musculus	158-163
12754374-7	2003	Daily injection of adrenaline, administered at a fixed time for 6 days, recovered oscillations of mPer2 and mBmal1 gene expression in the liver of mice with SCN lesion on day 7.	Epinephrine	19-29	period circadian clock 2	Mus musculus	98-103
12754374-7	2003	Daily injection of adrenaline, administered at a fixed time for 6 days, recovered oscillations of mPer2 and mBmal1 gene expression in the liver of mice with SCN lesion on day 7.	Epinephrine	19-29	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	108-114
12713515-7	2003	CONCLUSIONS: In slow-twitch oxidative as well as in fast-twitch glycolytic muscle HSL is activated by both adrenaline and contractions.	Epinephrine	107-117	lipase E, hormone sensitive type	Rattus norvegicus	82-85
12729923-3	2003	Epinephrine (1 microM; alpha,beta-adrenergic agonist) up-regulated expression of Int alphaV, CA-II and Cathe K in the osteoclast-like MNCs.	Epinephrine	0-11	carbonic anhydrase 2	Homo sapiens	93-98
12713515-0	2003	Additivity of adrenaline and contractions on hormone-sensitive lipase, but not on glycogen phosphorylase, in rat muscle.	Epinephrine	14-24	lipase E, hormone sensitive type	Rattus norvegicus	45-69
12713515-4	2003	RESULTS: Hormone-sensitive lipase activity was increased significantly by adrenaline as well as contractions, and the highest activity (P &lt; 0.05) was seen with combined stimulation [Soleus: 0.40 +/- 0.03 (SE) m-unit mg protein(-1) (basal), 0.65 +/- 0.02 (adrenaline), 0.65 +/- 0.03 (contractions), 0.78 +/- 0.03 (adrenaline and contractions); EDL: 0.18 +/- 0.01, 0.30 +/- 0.02, 0.26 +/- 0.02, 0.32 +/- 0.01].	Epinephrine	74-84	lipase E, hormone sensitive type	Rattus norvegicus	9-33
12713515-9	2003	Contractions may impair the enhancing effect of adrenaline on glycogen phosphorylase activity in muscle.	Epinephrine	48-58	glycogen phosphorylase L	Rattus norvegicus	62-84
12713515-5	2003	Glycogen phosphorylase activity was always increased more by adrenaline compared with contractions [Soleus: 60 +/- 4 (a/a + b)% vs. 46 +/- 3 (P &lt; 0.05); EDL: 60 +/- 5 vs. 39 +/- 6 (P &lt; 0.05)].	Epinephrine	61-71	glycogen phosphorylase L	Rattus norvegicus	0-22
12519093-0	2003	Effects of common polymorphisms in the alpha1A-, alpha2B-, beta1- and beta2-adrenoreceptors on haemodynamic responses to adrenaline.	Epinephrine	121-131	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	39-46
12519093-4	2003	The Cys/Cys (CC) genotype of the alpha(1A)-AR R492C polymorphism was associated with a longer ECG PR interval before and during the adrenaline infusions.	Epinephrine	132-142	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	33-41
12519093-4	2003	The Cys/Cys (CC) genotype of the alpha(1A)-AR R492C polymorphism was associated with a longer ECG PR interval before and during the adrenaline infusions.	Epinephrine	132-142	adrenoceptor beta 2	Homo sapiens	43-45
12871375-0	2003	The promoting effect of epinephrine on lipopolysaccharide-induced interleukin-8 production in whole blood may be mediated by thromboxane A2.	Epinephrine	24-35	C-X-C motif chemokine ligand 8	Homo sapiens	66-79
12871375-1	2003	Epinephrine is known to enhance lipopolysaccharide (LPS)-induced interleukin (IL)-8 secretion in a platelet dependent manner.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	65-83
12871375-3	2003	ASA ingestion significantly (global P &lt; 0.05) reduced the enhancing effect of epinephrine on LPS-induced IL-8 release by 15-28%.	Epinephrine	81-92	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
12871375-5	2003	U46619 mimicked the epinephrine effect: 20 ng mL(-1) U46619 enhanced LPS-induced IL-8 release by 39% (P &lt; 0.05).	Epinephrine	20-31	C-X-C motif chemokine ligand 8	Homo sapiens	81-85
12871375-6	2003	Furthermore, preincubation of whole blood with 75 micro mol L-1 or 150 micromol L(-1) SQ29548, a TxA2 receptor antagonist, completely blocked epinephrine"s promoting effect on LPS-induced IL-8 release.	Epinephrine	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	188-192
12706465-6	2003	Acute bilateral adrenalectomy abolished the elevation of both noradrenaline and adrenaline induced by vasopressin, while the procedure reduced only the elevation of adrenaline induced by CRH.	Epinephrine	65-75	arginine vasopressin	Rattus norvegicus	102-113
12706465-3	2003	Intracerebroventricularly administered vasopressin (0.2 nmol/animal) and CRH (1.5 nmol/animal) elevated plasma levels of noradrenaline and adrenaline.	Epinephrine	124-134	arginine vasopressin	Rattus norvegicus	39-50
12706465-6	2003	Acute bilateral adrenalectomy abolished the elevation of both noradrenaline and adrenaline induced by vasopressin, while the procedure reduced only the elevation of adrenaline induced by CRH.	Epinephrine	80-90	arginine vasopressin	Rattus norvegicus	102-113
12706465-3	2003	Intracerebroventricularly administered vasopressin (0.2 nmol/animal) and CRH (1.5 nmol/animal) elevated plasma levels of noradrenaline and adrenaline.	Epinephrine	124-134	corticotropin releasing hormone	Rattus norvegicus	73-76
12706465-9	2003	The vasopressin- and CRH-induced adrenaline release from adrenal medulla is also mediated by brain thromboxane A(2)-mediated mechanisms in rats.	Epinephrine	33-43	arginine vasopressin	Rattus norvegicus	4-15
12706465-9	2003	The vasopressin- and CRH-induced adrenaline release from adrenal medulla is also mediated by brain thromboxane A(2)-mediated mechanisms in rats.	Epinephrine	33-43	corticotropin releasing hormone	Rattus norvegicus	21-24
14509133-2	2003	The administration of exogenous vasopressin during closed and open cardiopulmonary resuscitation in humans was shown to be more effective than optimal doses of epinephrine in several clinical studies.	Epinephrine	160-171	arginine vasopressin	Homo sapiens	32-43
17021455-6	2003	Clinical experience on the use of vasopressin for in-hospital cardiopulmonary resuscitation with short response time showed equipotency with epinephrine; in patients with out-of-hospital ventricular fibrillation, vasopressin showed improved 24 h survival in comparison with epinephrine.	Epinephrine	141-152	arginine vasopressin	Homo sapiens	34-45
17021455-6	2003	Clinical experience on the use of vasopressin for in-hospital cardiopulmonary resuscitation with short response time showed equipotency with epinephrine; in patients with out-of-hospital ventricular fibrillation, vasopressin showed improved 24 h survival in comparison with epinephrine.	Epinephrine	274-285	arginine vasopressin	Homo sapiens	34-45
17021455-6	2003	Clinical experience on the use of vasopressin for in-hospital cardiopulmonary resuscitation with short response time showed equipotency with epinephrine; in patients with out-of-hospital ventricular fibrillation, vasopressin showed improved 24 h survival in comparison with epinephrine.	Epinephrine	274-285	arginine vasopressin	Homo sapiens	213-224
12746566-3	2003	The expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for production of epinephrine from norepinephrine, is common to both mouse and human pheochromocytomas.	Epinephrine	106-117	phenylethanolamine-N-methyltransferase	Mus musculus	18-56
12746566-3	2003	The expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme responsible for production of epinephrine from norepinephrine, is common to both mouse and human pheochromocytomas.	Epinephrine	106-117	phenylethanolamine-N-methyltransferase	Mus musculus	58-62
12506027-3	2003	Here we report a novel role for epinephrine and cyclic adenosine monophosphate (cAMP) in the regulation of human SS RBC adhesiveness via the laminin receptor, basal cell adhesion molecule/Lutheran (BCAM/Lu).	Epinephrine	32-43	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	198-202
12506027-6	2003	Epinephrine-stimulated adhesion to laminin, mediated primarily via the beta 2-adrenergic receptor, occurred in SS RBC samples from 46% of patients and was blocked by recombinant, soluble BCAM/Lu, implicating this receptor as a target of cAMP signaling.	Epinephrine	0-11	adrenoceptor beta 2	Homo sapiens	71-97
12506027-6	2003	Epinephrine-stimulated adhesion to laminin, mediated primarily via the beta 2-adrenergic receptor, occurred in SS RBC samples from 46% of patients and was blocked by recombinant, soluble BCAM/Lu, implicating this receptor as a target of cAMP signaling.	Epinephrine	0-11	basal cell adhesion molecule (Lutheran blood group)	Homo sapiens	187-191
12966717-1	2003	It has been found that intravenous administration of nociceptin (0.4 mg/kg) prevents development of aconitine-induced arrhythmias but has no effect on the incidence of occlusion, reperfusion, CaCl2-induced arrhythmias, and exacerbates epinephrine-evoked dysrhythmias.	Epinephrine	235-246	prepronociceptin	Homo sapiens	53-63
12668296-12	2003	Adrenaline (epinephrine) applied via ETC with a 10-fold dosage was as effective as via the conventional ETA.	Epinephrine	0-10	endothelin receptor type A	Homo sapiens	104-107
12706382-0	2003	Epinephrine modulates cellular distribution of muscle phosphofructokinase.	Epinephrine	0-11	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	54-73
12706382-1	2003	In this paper, we report evidences that cellular distribution of phosphofructokinase can be affected by epinephrine stimulation in rabbit skeletal muscle homogenates.	Epinephrine	104-115	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	65-84
12706382-2	2003	Through co-sedimentation techniques, we observed that in epinephrine-stimulated tissues, approximately 50% of phosphofructokinase activity is co-located in an actin-enriched fraction, against 29% in control.	Epinephrine	57-68	ATP-dependent 6-phosphofructokinase, muscle type	Oryctolagus cuniculus	110-129
12556353-12	2003	The increased activation of PDH was not explained by changes in muscle pyruvate or the ATP/ADP ratio but may be related to a decrease in the NADH/NAD(+) ratio or an epinephrine-induced increase in calcium concentration.	Epinephrine	165-176	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	28-31
12609750-2	2003	Ang II stimulates norepinephrine (NE), epinephrine (EP) and NPY release from perifused chromaffin cells by 3-, 2- and 12-fold, respectively.	Epinephrine	21-32	angiogenin	Homo sapiens	0-3
12818251-8	2003	This effect was further enhanced in carriers of the GPIIIa Pl(A2) allele (2 microM ADP: 42% vs. 19%, p=0.017; 1 microM U-46619: 51% vs. 30%, p=0.03; 5 microM epinephrine: 69% vs. 53%, p=0.025).	Epinephrine	158-169	integrin subunit beta 3	Homo sapiens	52-58
12668296-12	2003	Adrenaline (epinephrine) applied via ETC with a 10-fold dosage was as effective as via the conventional ETA.	Epinephrine	12-23	endothelin receptor type A	Homo sapiens	104-107
12608810-6	2003	Finally, a new allylation-bromocyclization reaction was demonstrated and used in the synthesis of a known inhibitor of phenylethanolamine N-methyltransferase (PNMT), an enzyme involved in the biosynthesis of adrenaline.	Epinephrine	208-218	phenylethanolamine N-methyltransferase	Homo sapiens	119-157
12608810-6	2003	Finally, a new allylation-bromocyclization reaction was demonstrated and used in the synthesis of a known inhibitor of phenylethanolamine N-methyltransferase (PNMT), an enzyme involved in the biosynthesis of adrenaline.	Epinephrine	208-218	phenylethanolamine N-methyltransferase	Homo sapiens	159-163
12642394-0	2003	Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation.	Epinephrine	72-82	adrenoceptor alpha 2A	Homo sapiens	19-40
12642394-0	2003	Desensitization of alpha 2A-adrenoceptor signalling by modest levels of adrenaline is facilitated by beta 2-adrenoceptor-dependent GRK3 up-regulation.	Epinephrine	72-82	G protein-coupled receptor kinase 3	Homo sapiens	131-135
12606499-7	2003	CRH- (and insulin-treated) animals showed markedly reduced epinephrine responses (CRH 1,276 +/- 404 pg/ml, controls 3,559 +/- 563 pg/ml; P &lt; 0.05).	Epinephrine	59-70	corticotropin releasing hormone	Rattus norvegicus	0-3
12606499-7	2003	CRH- (and insulin-treated) animals showed markedly reduced epinephrine responses (CRH 1,276 +/- 404 pg/ml, controls 3,559 +/- 563 pg/ml; P &lt; 0.05).	Epinephrine	59-70	corticotropin releasing hormone	Rattus norvegicus	82-85
12606499-11	2003	The addition of a CRH receptor 1 (CRHr1) antagonist to the antecedent CRH reversed the subsequent suppression of epinephrine.	Epinephrine	113-124	corticotropin releasing hormone receptor 1	Rattus norvegicus	18-32
12606499-11	2003	The addition of a CRH receptor 1 (CRHr1) antagonist to the antecedent CRH reversed the subsequent suppression of epinephrine.	Epinephrine	113-124	corticotropin releasing hormone receptor 1	Rattus norvegicus	34-39
12606499-11	2003	The addition of a CRH receptor 1 (CRHr1) antagonist to the antecedent CRH reversed the subsequent suppression of epinephrine.	Epinephrine	113-124	corticotropin releasing hormone	Rattus norvegicus	18-21
12591599-6	2003	However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT.	Epinephrine	9-19	ret proto-oncogene	Mus musculus	187-192
12674997-15	2003	However, NIF may rather worsen electrophysiological function in the sinus node after administration of high doses of epinephrine, and may induce sinus bradycardia and/or sinus arrest.	Epinephrine	117-128	S100 calcium binding protein A9	Homo sapiens	9-12
12674997-16	2003	Careful observation, such as monitoring of electrocardiography and blood pressure and temporary cardiac pacemaker use, is needed to prevent death in patients surviving after cardiopulmonary arrest if NIF is administered following high dose epinephrine infusion.	Epinephrine	240-251	S100 calcium binding protein A9	Homo sapiens	200-203
12591599-6	2003	However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT.	Epinephrine	82-92	phenylethanolamine-N-methyltransferase	Mus musculus	113-151
12591599-6	2003	However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT.	Epinephrine	82-92	phenylethanolamine-N-methyltransferase	Mus musculus	153-157
12591599-6	2003	However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT.	Epinephrine	82-92	ret proto-oncogene	Mus musculus	187-192
12591599-6	2003	However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT.	Epinephrine	82-92	ret proto-oncogene	Mus musculus	249-254
12591599-6	2003	However, adrenaline levels and numbers of chromaffin cells immunoreactive for the adrenaline synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) are reduced by about 30% in c-Ret-deficient mice arguing for a direct or indirect role of c-Ret in the regulation of PNMT.	Epinephrine	82-92	phenylethanolamine-N-methyltransferase	Mus musculus	276-280
12591155-7	2003	Furthermore, evidence was obtained that (i) adrenaline and noradrenaline share the same binding site, and that this site would correspond to a repeated sequence present in the SCO-spondin, the major protein component of RF; and (ii) serotonin has its own binding site in RF.	Epinephrine	44-54	SCO-spondin	Bos taurus	176-187
12620376-9	2003	The enhancing effect of iNOS synthesis by epinephrine and norepinephrine on LPS-induced macrophages was down regulated by beta-adrenoceptor antagonist, propranolol, and dexamethasone.	Epinephrine	42-53	nitric oxide synthase 2, inducible	Mus musculus	24-28
12538206-0	2003	Adrenaline inhibits lipopolysaccharide-induced macrophage inflammatory protein-1 alpha in human monocytes: the role of beta-adrenergic receptors.	Epinephrine	0-10	C-C motif chemokine ligand 3	Homo sapiens	47-86
12598076-1	2003	OBJECTIVES: This study was designed to test the hypothesis that epinephrine infusion may be a provocative test able to unmask nonpenetrant KCNQ1 mutation carriers.	Epinephrine	64-75	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	139-144
12598076-8	2003	CONCLUSIONS: Epinephrine challenge is a powerful test to establish electrocardiographic diagnosis in silent LQT1 mutation carriers, thus allowing implementation of prophylactic measures aimed at reducing sudden cardiac death.	Epinephrine	13-24	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	108-112
12464610-3	2003	One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine.	Epinephrine	81-92	amine oxidase, copper containing 1	Rattus norvegicus	31-52
12464610-3	2003	One such protein is a biogenic amine-binding protein (ABP) that binds serotonin, epinephrine, and norepinephrine.	Epinephrine	81-92	amine oxidase, copper containing 1	Rattus norvegicus	54-57
12538206-2	2003	Our study was conducted to investigate the effect of adrenaline on lipopolysaccharide (LPS)-induced MIP-1 alpha production by human peripheral blood monocytes and human monocytic THP-1 cells.	Epinephrine	53-63	C-C motif chemokine ligand 3	Homo sapiens	100-111
12538206-4	2003	The effects of adrenaline on MIP-1 alpha synthesis were studied at the protein level by using enzyme-linked immunosorbent assays and at the messenger RNA level by using reverse transcriptase-polymerase chain reaction.	Epinephrine	15-25	C-C motif chemokine ligand 3	Homo sapiens	29-40
12538206-5	2003	Adrenaline inhibited LPS-induced MIP-1 alpha production in a dose-dependent manner.	Epinephrine	0-10	C-C motif chemokine ligand 3	Homo sapiens	33-44
12538206-9	2003	Furthermore, we found that adrenaline inhibited LPS-induced MIP-1 alpha messenger RNA expression.	Epinephrine	27-37	C-C motif chemokine ligand 3	Homo sapiens	60-71
12538206-10	2003	These findings suggest that adrenaline can modulate MIP-1 alpha production in inflammatory diseases and sepsis.	Epinephrine	28-38	C-C motif chemokine ligand 3	Homo sapiens	52-63
12582831-1	2003	We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK).	Epinephrine	116-127	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	257-273
12490549-5	2003	Combined immunocytochemical experiments with antibodies directed against phenylethanolamine N-methyltransferase and ERG channels suggested expression of these channels in epinephrine- but not in norepinephrine-containing cells.	Epinephrine	171-182	phenylethanolamine-N-methyltransferase	Rattus norvegicus	73-111
12582831-1	2003	We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK).	Epinephrine	116-127	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	275-278
12582831-1	2003	We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK).	Epinephrine	116-127	protein kinase C, epsilon	Rattus norvegicus	281-305
12582831-1	2003	We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK).	Epinephrine	116-127	protein kinase C, epsilon	Rattus norvegicus	307-317
12582831-2	2003	Epinephrine hyperalgesia and that induced by a selective activator of PKCepsilon, psiepsilonRACK, were inhibited by nordihydroguaretic acid (NDGA, non-selective lipoxygenase inhibitor), baicalein (BAIC, 12-lipoxygenase inhibitor) and 5, 6-dehydroarachidonic acid (5, 6-dhAA, 5-lipoxygenase inhibitor).	Epinephrine	0-11	protein kinase C, epsilon	Rattus norvegicus	70-80
12582831-2	2003	Epinephrine hyperalgesia and that induced by a selective activator of PKCepsilon, psiepsilonRACK, were inhibited by nordihydroguaretic acid (NDGA, non-selective lipoxygenase inhibitor), baicalein (BAIC, 12-lipoxygenase inhibitor) and 5, 6-dehydroarachidonic acid (5, 6-dhAA, 5-lipoxygenase inhibitor).	Epinephrine	0-11	arachidonate 5-lipoxygenase	Rattus norvegicus	275-289
12648816-5	2003	The aqueous extract (560 mg/ml) significantly reduced the contractile responses of vas deferens to epinephrine (1 microM) without any change in contraction induced by KCl (300 mM).	Epinephrine	99-110	arginine vasopressin	Rattus norvegicus	83-86
12538816-6	2003	In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR.	Epinephrine	61-72	interleukin 18	Homo sapiens	119-124
12538816-3	2003	In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation.	Epinephrine	39-50	interleukin 18	Homo sapiens	97-102
12538816-6	2003	In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR.	Epinephrine	61-72	tumor necrosis factor	Homo sapiens	171-198
12538816-3	2003	In the present study, we found that norepinephrine, epinephrine, or isoproterenol down-regulated IL-18 (100 ng/ml)-induced intercellular adhesion molecule (ICAM)-1 expression on monocytes in a dose-dependent manner (10(-8)-10(-4) M), but did not effect B7.1 and B7.2 expression after 24-h incubation.	Epinephrine	39-50	intercellular adhesion molecule 1	Homo sapiens	137-163
12538816-6	2003	In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR.	Epinephrine	61-72	interferon gamma	Homo sapiens	202-218
12538816-6	2003	In the same manner, salbutanol and terbutaline as well as norepinephrine, epinephrine, and isoproterenol regulated the IL-18-induced cytokine production, including IL-12, tumor necrosis factor-alpha or interferon-gamma through the stimulation of beta 2-AR.	Epinephrine	61-72	adrenoceptor beta 2	Homo sapiens	246-255
12407113-4	2003	Two unrelated inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, totally prevented Rap1B activation in platelets stimulated by cross-linking of FcgammaRIIA, by stimulation of the P2Y(12) receptor for ADP, or by epinephrine.	Epinephrine	237-248	RAP1B, member of RAS oncogene family	Homo sapiens	109-114
12574814-6	2003	In contrast, platelet activation with TRAP, epinephrine, or ADP produced markedly increased gC1qR expression as reflected by 74.5.2 binding but not 60.11 binding.	Epinephrine	44-55	complement C1q binding protein	Homo sapiens	92-97
12407113-4	2003	Two unrelated inhibitors of phosphatidylinositol 3-kinase (PI3K), wortmannin and LY294002, totally prevented Rap1B activation in platelets stimulated by cross-linking of FcgammaRIIA, by stimulation of the P2Y(12) receptor for ADP, or by epinephrine.	Epinephrine	237-248	Fc gamma receptor IIa	Homo sapiens	170-181
12407113-5	2003	However, in platelets from PI3Kgamma-deficient mice, both ADP and epinephrine were still able to normally stimulate Rap1B activation through a PI3K-dependent mechanism, suggesting the involvement of a different isoform of the enzyme.	Epinephrine	66-77	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	27-36
12407113-5	2003	However, in platelets from PI3Kgamma-deficient mice, both ADP and epinephrine were still able to normally stimulate Rap1B activation through a PI3K-dependent mechanism, suggesting the involvement of a different isoform of the enzyme.	Epinephrine	66-77	RAS related protein 1b	Mus musculus	116-121
12511226-5	2003	RESULTS: Platelet aggregation mediated by subthreshold concentrations of PAF (5-8 nmol/L) plus epinephrine (0.5-2 micromol/L) was inhibited by ?2-receptor blocker, yohimbine, and PAF receptor antagonist WEB 2086.	Epinephrine	95-106	PCNA clamp associated factor	Homo sapiens	179-182
12542666-12	2003	We conclude that (1) long-lasting sensitization induced by single exposure to IL-1 and amphetamine induces specific pattern of neuroplastic changes in (nor)adrenergic innervation in the PVN and (2) reduction of relative DBH innervation density in CRH-rich areas is associated with paradoxical increase of electrically evoked release of (nor)adrenaline.	Epinephrine	341-351	dopamine beta-hydroxylase	Rattus norvegicus	220-223
12401525-3	2003	PLD could also be activated by epinephrine and AlF(4)(-), two polyphosphoinositide-specific phospholipase C (PPI-PLC) activators, and by the phorbol ester o-tetradecanoylphorbol 13-acetate (TPA) which activates protein kinase C (PKC).	Epinephrine	31-42	plasminogen activator, tissue type	Rattus norvegicus	155-194
12891655-1	2003	Tyrosine hydroxylase (TH) is the key enzyme in the biosynthesis of the catecholamines dopamine, epinephrine, and norepinephrine.	Epinephrine	96-107	tyrosine hydroxylase	Homo sapiens	0-20
12891655-1	2003	Tyrosine hydroxylase (TH) is the key enzyme in the biosynthesis of the catecholamines dopamine, epinephrine, and norepinephrine.	Epinephrine	96-107	tyrosine hydroxylase	Homo sapiens	22-24
12652014-2	2003	The aim of this work was to study the adrenaline effect on erythrocyte membrane fluidity, acetylcholinesterase (AChE) enzyme activity, P(50) and erythrocyte deformability and also to verify if the role of adrenaline on erythrocyte properties is sex-dependent.	Epinephrine	38-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	90-110
12652014-2	2003	The aim of this work was to study the adrenaline effect on erythrocyte membrane fluidity, acetylcholinesterase (AChE) enzyme activity, P(50) and erythrocyte deformability and also to verify if the role of adrenaline on erythrocyte properties is sex-dependent.	Epinephrine	38-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	112-116
12652014-5	2003	In female, adrenaline decreases AChE activity either when alpha and beta-adrenergic receptors are blocked (p&lt;or=0.01) or when they are not.	Epinephrine	11-21	acetylcholinesterase (Cartwright blood group)	Homo sapiens	32-36
12652014-6	2003	In male, adrenaline increases AChE activity when none of adrenergic receptors are blocked.	Epinephrine	9-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	30-34
12488332-0	2003	Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus.	Epinephrine	19-30	neuropeptide Y	Homo sapiens	123-137
12488332-0	2003	Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus.	Epinephrine	19-30	agouti related neuropeptide	Homo sapiens	142-169
12456365-7	2003	Co-immunoprecipitation displayed binding of PKC to GRK2 in intact Jurkat cells after prolonged stimulation of epinephrine.	Epinephrine	110-121	proline rich transmembrane protein 2	Homo sapiens	44-47
14509925-4	2003	After preliminary inhibiting nNOS chemoreceptor reflexes induced by epinephrine were found to be enhanced in most experiments.	Epinephrine	68-79	nitric oxide synthase 1	Rattus norvegicus	29-33
12456365-7	2003	Co-immunoprecipitation displayed binding of PKC to GRK2 in intact Jurkat cells after prolonged stimulation of epinephrine.	Epinephrine	110-121	G protein-coupled receptor kinase 2	Homo sapiens	51-55
12460640-3	2002	administered vasopressin (0.1, 0.2 and 0.5 nmol/animal) dose-dependently elevated plasma levels of adrenaline and noradrenaline (adrenaline&gt;noradrenaline).	Epinephrine	99-109	arginine vasopressin	Rattus norvegicus	13-24
12297510-3	2002	ERK5 is activated by forskolin, isoproterenol, and epinephrine in NIH3T3 cells and C2C12 myoblasts.	Epinephrine	51-62	mitogen-activated protein kinase 7	Mus musculus	0-4
12676191-6	2002	This shear-induced platelet surface translocation of CD40L, mediated by the von Willebrand factor (VWF)-GP Ibalpha interaction, was enhanced in the presence of a low concentration of epinephrine (100 nM), which by itself, however, could not cause platelet activation.	Epinephrine	183-194	CD40 ligand	Homo sapiens	53-58
12676191-6	2002	This shear-induced platelet surface translocation of CD40L, mediated by the von Willebrand factor (VWF)-GP Ibalpha interaction, was enhanced in the presence of a low concentration of epinephrine (100 nM), which by itself, however, could not cause platelet activation.	Epinephrine	183-194	von Willebrand factor	Homo sapiens	76-97
12509497-8	2003	Thigh IL-6 release was also positively related to arterial plasma adrenaline concentration.	Epinephrine	66-76	interleukin 6	Homo sapiens	6-10
12676191-6	2002	This shear-induced platelet surface translocation of CD40L, mediated by the von Willebrand factor (VWF)-GP Ibalpha interaction, was enhanced in the presence of a low concentration of epinephrine (100 nM), which by itself, however, could not cause platelet activation.	Epinephrine	183-194	von Willebrand factor	Homo sapiens	99-102
12471309-10	2002	The increased level of adrenaline contributes to the enormous increase in plasma IL-6 only to a minor degree during strenuous exercise.	Epinephrine	23-33	interleukin 6	Homo sapiens	81-85
12477685-4	2002	RESULTS: Infusion rates up to 0.05 microg x kg(-1) x min(-1) were effective against agitation and achieved a good degree of adaption to the respirator in all patients (RSS 2 or more and CSRR 3 or less); BIS decreased significantly; respiratory and circulatory variables were unaffected; mean plasma epinephrine levels decreased.	Epinephrine	299-310	CD59 molecule (CD59 blood group)	Homo sapiens	53-59
12218046-8	2002	To demonstrate the importance of the AKAPs, inhibition of PKA-AKAP binding with a peptide competitor (HT31) prevented epinephrine-mediated inhibition of LPL translation.	Epinephrine	118-129	lipoprotein lipase	Homo sapiens	153-156
12433597-9	2002	administered interleukin-1beta (100 ng/animal) elevated plasma levels of noradrenaline but not adrenaline.	Epinephrine	76-86	interleukin 1 beta	Rattus norvegicus	13-30
12458069-8	2002	At the same time CBF decreased in the control and adrenaline group from 36 (21; 41) and 39 (15; 50) to 12 (2; 25) and 24 (15; 26) ml min(-1) per 100 g, respectively, (P&lt;0.05 adrenaline vs. endothelin-1 200 microg).	Epinephrine	50-60	endothelin-1	Sus scrofa	192-204
12384466-7	2002	In the whole animal (anesthetized mice), EGF administration reduced the rise in heart rate induced by a single epinephrine dose and the occurrence of Bezold-Jarisch reflex episodes induced by repeated doses.	Epinephrine	111-122	epidermal growth factor	Mus musculus	41-44
12376414-3	2002	Gene expression for uncoupling proteins 1 and 3, GLUT-4, leptin, and the alpha(1A)-adrenergic receptor was more abundant in BAT and the increase in epinephrine excretion with fasting suppressed in 18 degrees C-reared animals.	Epinephrine	148-159	uncoupling protein 1	Rattus norvegicus	20-47
12376414-3	2002	Gene expression for uncoupling proteins 1 and 3, GLUT-4, leptin, and the alpha(1A)-adrenergic receptor was more abundant in BAT and the increase in epinephrine excretion with fasting suppressed in 18 degrees C-reared animals.	Epinephrine	148-159	solute carrier family 2 member 4	Rattus norvegicus	49-55
12376414-3	2002	Gene expression for uncoupling proteins 1 and 3, GLUT-4, leptin, and the alpha(1A)-adrenergic receptor was more abundant in BAT and the increase in epinephrine excretion with fasting suppressed in 18 degrees C-reared animals.	Epinephrine	148-159	adrenoceptor alpha 1D	Rattus norvegicus	73-102
12384466-9	2002	All these results suggest that, by interfering with beta-AR signaling, EGF protects the heart against the harmful effects of epinephrine.	Epinephrine	125-136	epidermal growth factor	Mus musculus	71-74
12384466-9	2002	All these results suggest that, by interfering with beta-AR signaling, EGF protects the heart against the harmful effects of epinephrine.	Epinephrine	125-136	adrenergic receptor, beta 1	Mus musculus	52-59
12381748-1	2002	We recently demonstrated that epinephrine could inhibit the activation by insulin of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase) in skeletal muscle (Hunt DG, Zhenping D, and Ivy JL.	Epinephrine	30-41	insulin receptor substrate 1	Rattus norvegicus	85-113
12381748-1	2002	We recently demonstrated that epinephrine could inhibit the activation by insulin of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase (PI3-kinase) in skeletal muscle (Hunt DG, Zhenping D, and Ivy JL.	Epinephrine	30-41	insulin receptor substrate 1	Rattus norvegicus	115-120
12381748-7	2002	This inhibition of glucose transport by epinephrine was accompanied by suppression of IRS-1-associated PI3-kinase activation.	Epinephrine	40-51	insulin receptor substrate 1	Rattus norvegicus	86-91
12381748-11	2002	The inhibition of glucose transport by epinephrine appears to involve the inhibition of IRS-1-associated PI3-kinase activation.	Epinephrine	39-50	insulin receptor substrate 1	Rattus norvegicus	88-93
12491798-1	2002	beta-Adrenoceptor subtypes which mediate relaxation of guinea-pig gastrointestinal smooth muscles in response to catecholamines ((-)-isoprenaline, (-)-noradrenaline and (-)-adrenaline) and beta 3-adrenoceptor agonists (BRL37344 and (+/-)-CGP12177A) are predominantly beta 3-adrenoceptors.	Epinephrine	169-183	beta-3 adrenergic receptor	Cavia porcellus	189-208
12391272-7	2002	We also found maximal activation of ERK1/2 in the overexpressing cell lines at concentrations of epinephrine that cause no internalization (i.e., the EC(50) for internalization was 75 nM).	Epinephrine	97-108	mitogen-activated protein kinase 3	Homo sapiens	36-42
12391272-8	2002	Pertussis toxin pretreatment caused only a weak inhibition of epinephrine activation of ERK1/2 in the HEK293 (7-16%) and no inhibition in the PKA(-) cells.	Epinephrine	62-73	mitogen-activated protein kinase 3	Homo sapiens	88-94
12417430-0	2002	NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization.	Epinephrine	14-25	neuropeptide Y	Rattus norvegicus	0-3
12417430-0	2002	NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization.	Epinephrine	14-25	neuropeptide Y receptor Y5	Rattus norvegicus	59-71
12438093-1	2002	Phenylethanolamine N-methyltransferase (PNMT) methylates norepinephrine (NE) to form epinephrine (E).	Epinephrine	60-71	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
12270752-4	2002	Adrenaline augmented hydroxyl radicals in a concentration-dependent manner and was blocked by chloroethylclonidine, an alpha(1B)-adrenoceptor antagonist, while adrenaline plus ethanol added their individual effects.	Epinephrine	0-10	adrenoceptor alpha 1B	Rattus norvegicus	119-141
12270752-5	2002	It is suggested that adrenaline increases hydroxyl radicals by an alpha(1B)-adrenoceptor-mediated mechanism, while ethanol does so by a receptor-independent mechanism.	Epinephrine	21-31	adrenoceptor alpha 1B	Rattus norvegicus	66-88
12429357-3	2002	The functional status of alpha(2A)-adrenergic receptor-coupled G(i2) and thrombin receptor-coupled G proteins (G(i2)+G(q)) was determined by the increase in high-affinity GTPase activity in response to epinephrine and thrombin, respectively, in platelet membranes from 18 patients with mood disorders (15 unipolar and three bipolar subtype), 13 schizophrenic patients, four neurotic patients and 29 healthy control subjects.	Epinephrine	202-213	coagulation factor II, thrombin	Homo sapiens	73-81
12438093-1	2002	Phenylethanolamine N-methyltransferase (PNMT) methylates norepinephrine (NE) to form epinephrine (E).	Epinephrine	60-71	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
12242714-1	2002	There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways.	Epinephrine	119-130	adrenergic receptor, alpha 2a	Mus musculus	55-62
12533769-1	2002	Activities of succinate dehydrogenase (SDH) and alpha-glycerophosphate dehydrogenase (hyaloplasmic and mitochondrial: alpha-GPDHH and alpha-GPDHM) in peripheral blood lymphocytes, and the response of SDH activity to exogenous epinephrine in vitro (the epinephrine test) were studied in 20 healthy subjects and 46 patients with hypertensive neurocirculatory dystonia.	Epinephrine	226-237	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	14-37
12431311-7	2002	In this review article, sympathetic stimulation with isoproterenol or epinephrine infusion is demonstrated to modulate differentially these repolarization indices in the ECG as well as the action potentials of the three cells between the LQT1, LQT2, and LQT3 syndromes both experimentally and clinically, explaining the differences in the sensitivity of genotypes of congenital LQTS to sympathetic stimulation.	Epinephrine	70-81	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	238-242
12431311-7	2002	In this review article, sympathetic stimulation with isoproterenol or epinephrine infusion is demonstrated to modulate differentially these repolarization indices in the ECG as well as the action potentials of the three cells between the LQT1, LQT2, and LQT3 syndromes both experimentally and clinically, explaining the differences in the sensitivity of genotypes of congenital LQTS to sympathetic stimulation.	Epinephrine	70-81	potassium voltage-gated channel subfamily H member 2	Homo sapiens	244-248
12242714-1	2002	There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways.	Epinephrine	119-130	adrenergic receptor, alpha 2b	Mus musculus	64-71
12242714-1	2002	There are three subtypes of alpha2 adrenoceptor, i.e., alpha2A, alpha2B, and alpha2C, mediating the specific effect of epinephrine and norepinephrine in various tissues by means of G protein-coupled signal transduction pathways.	Epinephrine	119-130	adrenergic receptor, alpha 2c	Mus musculus	77-84
12419878-1	2002	Since the first discovery of mammalian receptors for adrenaline (beta(2)) and acetylcholine (M(1)) in 1986, many G protein-coupled receptors for known ligands have been cloned by protein purification, PCR (polymerase chain reaction) and low stringency hybridization, and they have been identified by expression cloning techniques.	Epinephrine	53-63	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	65-72
12107065-9	2002	Consistent with the notion of H(+)-ATPase inhibition in ANG II-treated NPE, bafilomycin A(1) (100 nM) (BAF) and ANG II were both observed to suppress the pH(i) increase that occurs upon exposure to a mixture of epinephrine (1 microM) and acetylcholine (10 microM) and the pH(i) increase elicited by depolarization.	Epinephrine	211-222	angiogenin	Oryctolagus cuniculus	112-115
12176961-2	2002	Using the microdialysis technique in the porcine heart, we investigated whether epinephrine, taken up by and released from cardiac sympathetic nerves, can increase norepinephrine concentrations in myocardial interstitial fluid (NE(MIF)) under basal conditions and during sympathetic activation.	Epinephrine	80-91	macrophage migration inhibitory factor	Homo sapiens	231-234
12176961-5	2002	Intracoronary infusion of tyramine resulted in a negligible increase in epinephrine concentration in myocardial interstitial fluid (EPI(MIF)), whereas 30 minutes after infusion of epinephrine an increase of 9.5 nmol/L in EPI(MIF) was observed, indicating that epinephrine is taken up by and released from cardiac sympathetic neurons.	Epinephrine	180-191	macrophage migration inhibitory factor	Homo sapiens	221-229
12176961-5	2002	Intracoronary infusion of tyramine resulted in a negligible increase in epinephrine concentration in myocardial interstitial fluid (EPI(MIF)), whereas 30 minutes after infusion of epinephrine an increase of 9.5 nmol/L in EPI(MIF) was observed, indicating that epinephrine is taken up by and released from cardiac sympathetic neurons.	Epinephrine	180-191	macrophage migration inhibitory factor	Homo sapiens	221-229
12351677-7	2002	We find that the predicted structure of beta1-adrenergic receptor leads to a binding site for epinephrine that agrees well with the mutation experiments.	Epinephrine	94-105	adrenoceptor beta 1	Homo sapiens	40-65
12205187-10	2002	These data demonstrate that the VR1 receptor appears to be located presynaptically on afferents to the LC, and that activation of VR1 may serve to potentiate the release of glutamate and adrenaline/noradrenaline in this brain region.	Epinephrine	187-197	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-35
12205187-10	2002	These data demonstrate that the VR1 receptor appears to be located presynaptically on afferents to the LC, and that activation of VR1 may serve to potentiate the release of glutamate and adrenaline/noradrenaline in this brain region.	Epinephrine	187-197	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	130-133
12209131-1	2002	Since the discovery in 1957 that cyclic AMP acts as a second messenger for the hormone adrenaline, interest in this molecule and its companion, cyclic GMP, has grown.	Epinephrine	87-97	5'-nucleotidase, cytosolic II	Homo sapiens	151-154
12202245-3	2002	Alpha(2B)-AR bind natural (adrenaline and noradrenaline) and synthetic ligands with different affinities to mediate a variety of physiological and pharmacological responses.	Epinephrine	27-37	adrenoceptor alpha 2B	Homo sapiens	0-12
12068056-9	2002	This was not associated with activity changes of GS kinase 3 or protein phosphatase 1, but the changes in GS activity could be due to changes in activity of AMPK or protein kinase A (PKA) as a negative correlation between either ACCbeta phosphorylation (Ser(221)) or plasma adrenaline and GS activity was observed.	Epinephrine	274-284	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	157-161
12096893-2	2002	In this study, surprisingly high levels of the epinephrine synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) were detected in the thymus of young mice.	Epinephrine	47-58	phenylethanolamine-N-methyltransferase	Mus musculus	79-118
12096893-2	2002	In this study, surprisingly high levels of the epinephrine synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) were detected in the thymus of young mice.	Epinephrine	47-58	phenylethanolamine-N-methyltransferase	Mus musculus	120-124
12111350-0	2002	Effect of adrenaline and glucocorticoids on monocyte cAMP-specific phosphodiesterase (PDE4) in a monocytic cell line.	Epinephrine	10-20	phosphodiesterase 4A	Homo sapiens	86-90
12111350-6	2002	Adrenaline at a concentration of 1 micro M produced a two- to threefold selective increase in PDE4 activity in U-937 cells after 4 h of incubation with the hormone.	Epinephrine	0-10	phosphodiesterase 4A	Homo sapiens	94-98
12111350-8	2002	Cycloheximide (10 micro M) induced a blockade of adrenaline-induced stimulation of PDE4.	Epinephrine	49-59	phosphodiesterase 4A	Homo sapiens	83-87
12111350-12	2002	After 4 h of incubation in the presence of adrenaline, inhibition of cAMP degradation by rolipram further increased cAMP levels by about 300% and also enhanced PDE4 activity.	Epinephrine	43-53	phosphodiesterase 4A	Homo sapiens	160-164
12111350-13	2002	These results suggest that adrenaline-induced stimulation of PDE4 is mediated by the beta(2)-adrenoceptor and is related to intracellular levels of cAMP, which might trigger expression and synthesis of the enzyme.	Epinephrine	27-37	phosphodiesterase 4A	Homo sapiens	61-65
12111350-13	2002	These results suggest that adrenaline-induced stimulation of PDE4 is mediated by the beta(2)-adrenoceptor and is related to intracellular levels of cAMP, which might trigger expression and synthesis of the enzyme.	Epinephrine	27-37	adrenoceptor beta 2	Homo sapiens	85-105
12111350-15	2002	Of the two stress hormones assayed, PDE4 activity was shown to be sensitive to adrenaline elevation but resistant to changes in glucocorticoid levels in the U-937 monocytic cell line.	Epinephrine	79-89	phosphodiesterase 4A	Homo sapiens	36-40
12037376-3	2002	administered IL-1beta (100 ng/animal) effectively elevated plasma noradrenaline rather than plasma adrenaline.	Epinephrine	69-79	interleukin 1 beta	Rattus norvegicus	13-21
12037376-4	2002	In superior cervical ganglionectomized rats, however, IL-1beta significantly elevated adrenaline to a greater extent than noradrenaline, and they were attenuated by i.c.v.	Epinephrine	86-96	interleukin 1 beta	Rattus norvegicus	54-62
11965360-1	2002	Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction.	Epinephrine	105-116	phenylethanolamine-N-methyltransferase	Rattus norvegicus	19-57
11965360-1	2002	Gene expression of phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing conversion of norepinephrine to epinephrine, has been detected in rat spleen using the reverse transcription polymerase chain reaction.	Epinephrine	105-116	phenylethanolamine-N-methyltransferase	Rattus norvegicus	59-63
12210143-6	2002	The reconstitution study revealed that a small amount of adenosine diphosphate (ADP) from erythrocytes may play an important role in epinephrine-induced platelet aggregation (in whole blood), through mediation of P2Y1 receptors.	Epinephrine	133-144	purinergic receptor P2Y1	Homo sapiens	213-217
12067846-0	2002	Epinephrine effects on insulin-glucose dynamics: the labeled IVGTT two-compartment minimal model approach.	Epinephrine	0-11	insulin	Homo sapiens	23-30
11970953-4	2002	First, we show that platelets from mice lacking the G(alpha)(i) family member G(alpha)(z) (which couples to the alpha(2A) adrenergic receptor) are deficient in epinephrine-stimulated Rap1 activation.	Epinephrine	160-171	adrenergic receptor, alpha 2a	Mus musculus	112-141
11970953-4	2002	First, we show that platelets from mice lacking the G(alpha)(i) family member G(alpha)(z) (which couples to the alpha(2A) adrenergic receptor) are deficient in epinephrine-stimulated Rap1 activation.	Epinephrine	160-171	RAS-related protein 1a	Mus musculus	183-187
12113477-4	2002	Epinephrine induced neuronal differentiation of PC12alpha2 cells through alpha2-AR activation in a subtype-dependent manner, internalization of all human alpha2-AR subtypes, and activation of mitogen-activated protein kinase (MAPK) and the serine-threonine protein kinase Akt.	Epinephrine	0-11	AKT serine/threonine kinase 1	Homo sapiens	272-275
12069453-7	2002	Epinephrine also prolonged the QTc dramatically (502+/-23 to 620+/-39 ms; P&lt;0.0005, +24%) at peak of epinephrine in LQT2 patients, but this shortened to baseline levels at steady state (531+/-25 ms; P=ns vs baseline, +6%).	Epinephrine	0-11	potassium voltage-gated channel subfamily H member 2	Homo sapiens	119-123
12069453-7	2002	Epinephrine also prolonged the QTc dramatically (502+/-23 to 620+/-39 ms; P&lt;0.0005, +24%) at peak of epinephrine in LQT2 patients, but this shortened to baseline levels at steady state (531+/-25 ms; P=ns vs baseline, +6%).	Epinephrine	104-115	potassium voltage-gated channel subfamily H member 2	Homo sapiens	119-123
12113477-6	2002	The MAPK kinase (MEK-1) inhibitor PD 98059 abolished the differentiating effect of epinephrine indicating that the differentiation is dependent on MAPK activation.	Epinephrine	83-94	mitogen activated protein kinase kinase 1	Rattus norvegicus	17-22
12015346-9	2002	These data suggest that the insulin antagonistic effects of caffeine in vivo are mediated by elevated epinephrine rather than by peripheral AR antagonism.	Epinephrine	102-113	insulin	Homo sapiens	28-35
12040535-4	2002	These high concentrations are needed to induce the medullary enzyme, phenylethanolamine-N-methyltransferase (PNMT), which controls the synthesis of epinephrine from norepinephrine.	Epinephrine	148-159	phenylethanolamine N-methyltransferase	Homo sapiens	69-107
12015346-2	2002	However, epinephrine, a potent inhibitor of insulin actions, is increased after caffeine ingestion.	Epinephrine	9-20	insulin	Homo sapiens	44-51
12040535-4	2002	These high concentrations are needed to induce the medullary enzyme, phenylethanolamine-N-methyltransferase (PNMT), which controls the synthesis of epinephrine from norepinephrine.	Epinephrine	148-159	phenylethanolamine N-methyltransferase	Homo sapiens	109-113
12004990-7	2002	During epinephrine infusion, every LQT1 patient manifested prolongation of the QT interval (paradoxical response), whereas healthy controls and patients with either LQT2 or LQT3 tended to have shortened QT intervals (P&lt;.001).	Epinephrine	7-18	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	35-39
12297011-0	2002	Epinephrine control of glycogen metabolism in glycogen-associated protein phosphatase PP1G/R(GL) knockout mice.	Epinephrine	0-11	protein phosphatase 1 catalytic subunit gamma	Mus musculus	86-90
11986218-8	2002	Incubation with histamine, forskolin, and epinephrine induced the rapid, coordinate release of both t-PA and VWF, consistent with a single storage compartment.	Epinephrine	42-53	plasminogen activator, tissue type	Homo sapiens	100-104
11986218-8	2002	Incubation with histamine, forskolin, and epinephrine induced the rapid, coordinate release of both t-PA and VWF, consistent with a single storage compartment.	Epinephrine	42-53	von Willebrand factor	Homo sapiens	109-112
11983297-4	2002	Triple-labeling immunofluorescence was performed to study the colocalization of NPY and phenylethanolamine N-methyltransferase (PNMT)--the key enzyme of adrenaline synthesis--in axons in association with hypophysiotropic TRH neurons.	Epinephrine	153-163	neuropeptide Y	Rattus norvegicus	80-83
11983297-4	2002	Triple-labeling immunofluorescence was performed to study the colocalization of NPY and phenylethanolamine N-methyltransferase (PNMT)--the key enzyme of adrenaline synthesis--in axons in association with hypophysiotropic TRH neurons.	Epinephrine	153-163	phenylethanolamine-N-methyltransferase	Rattus norvegicus	88-126
11983297-4	2002	Triple-labeling immunofluorescence was performed to study the colocalization of NPY and phenylethanolamine N-methyltransferase (PNMT)--the key enzyme of adrenaline synthesis--in axons in association with hypophysiotropic TRH neurons.	Epinephrine	153-163	phenylethanolamine-N-methyltransferase	Rattus norvegicus	128-132
12200739-2	2002	Lack of AADC leads to a combined deficiency of the catecholamines DA, norepinephrine (NE), epinephrine (E) as well as of serotonin.	Epinephrine	73-84	dopa decarboxylase	Homo sapiens	8-12
11959684-2	2002	In the Atlantic cod, we found that cod NPY (10(-10)-10(-6) M) relaxed celiac arteries precontracted with epinephrine, and weak contractions were elicited in intestinal ring preparations.	Epinephrine	105-116	neuropeptide Y	Homo sapiens	39-42
12006787-12	2002	CONCLUSIONS: In this pediatric porcine model of ventricular fibrillation, the combination of epinephrine with vasopressin during cardiopulmonary resuscitation resulted in significantly higher levels of left ventricular myocardial blood flow than either vasopressin alone or epinephrine alone.	Epinephrine	93-104	arginine vasopressin	Homo sapiens	253-264
12006787-12	2002	CONCLUSIONS: In this pediatric porcine model of ventricular fibrillation, the combination of epinephrine with vasopressin during cardiopulmonary resuscitation resulted in significantly higher levels of left ventricular myocardial blood flow than either vasopressin alone or epinephrine alone.	Epinephrine	274-285	arginine vasopressin	Homo sapiens	110-121
12004990-10	2002	Low-dose epinephrine (0.05 microg x kg(-1) x min(-1)) completely discriminated LQT1 patients (AQT, +82+/-34 ms) from controls (AQT, -7+/-13 ms; P&lt;.001).	Epinephrine	9-20	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	79-83
12004990-12	2002	CONCLUSIONS: Epinephrine-induced prolongation of the QT interval appears pathognomonic for LQT1.	Epinephrine	13-24	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	91-95
12004990-13	2002	Low-dose epinephrine infusion distinguishes controls from patients with concealed LQT1 manifesting an equivocal QTc at rest.	Epinephrine	9-20	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	82-86
11882511-0	2002	Activation of liver G-6-Pase in response to insulin-induced hypoglycemia or epinephrine infusion in the rat.	Epinephrine	76-87	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	20-28
12120815-10	2002	The inhibitory effect of daidzein and zearalenone on epinephrine-induced lipolysis is probably due to restriction of HSL action.	Epinephrine	53-64	lipase E, hormone sensitive type	Rattus norvegicus	117-120
11815620-8	2002	In platelets stimulated by cross-linking of FcgammaRIIA, inhibition of Rap1B activation by ADP scavengers could be overcome by the simultaneous recruitment of the G(i)-coupled alpha(2A)-adrenergic receptor by epinephrine.	Epinephrine	209-220	RAP1B, member of RAS oncogene family	Homo sapiens	71-76
11815620-10	2002	When tested alone, epinephrine was found to be able to induce GTP binding to Rap1B, whereas serotonin produced only a slight effect.	Epinephrine	19-30	RAP1B, member of RAS oncogene family	Homo sapiens	77-82
11815620-13	2002	These results demonstrate that stimulation of a G(i)-dependent signaling pathway by either ADP of epinephrine is necessary and sufficient to activate the small GTPase Rap1B.	Epinephrine	98-109	RAP1B, member of RAS oncogene family	Homo sapiens	167-172
11882511-5	2002	Infusion of epinephrine (1 microg x kg(-1) x min(-1)) in normal rats induced a dramatic 80% increase in EGP and a 60% increase in G-6-Pase activity.	Epinephrine	12-23	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	130-138
11882511-8	2002	Infusion of epinephrine in adrenalectomized rats restored a stimulation of G-6-Pase similar to that triggered by hypoglycemia in normal rats.	Epinephrine	12-23	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	75-83
11953644-1	2002	When stimulating adult pigs with ventricular fibrillation or postcountershock pulseless electrical activity for cardiopulmonary resuscitation, vasopressin improved vital organ blood flow, cerebral oxygen delivery, ability to be resuscitated, and neurologic recovery better than epinephrine.	Epinephrine	278-289	vasopressin	Sus scrofa	143-154
11996210-17	2002	PYC antagonizes the vasoconstriction caused by epinephrine and norepinephrine by increasing the activity of endothelial nitric oxide synthase.	Epinephrine	47-58	nitric oxide synthase 3	Homo sapiens	108-141
11953644-5	2002	In patients who experienced out-of-hospital ventricular fibrillation, a larger proportion of patients treated with vasopressin survived 24 hrs compared with patients treated with epinephrine; during in-hospital cardiopulmonary resuscitation, comparable short-term survival was found in groups treated with either vasopressin or epinephrine.	Epinephrine	328-339	arginine vasopressin	Homo sapiens	115-126
12018419-3	2002	The objective of this study was to determine whether feed restriction and (or) administration of epinephrine could recapitulate the changes in the hepatic GHR 1A and IGF-I mRNA that occur at parturition.	Epinephrine	97-108	growth hormone receptor	Bos taurus	155-158
12018419-3	2002	The objective of this study was to determine whether feed restriction and (or) administration of epinephrine could recapitulate the changes in the hepatic GHR 1A and IGF-I mRNA that occur at parturition.	Epinephrine	97-108	insulin like growth factor 1	Bos taurus	166-171
12831201-8	2002	The PNMT-IMER was then coupled in series using switching-valve technology with a previously developed dopamine beta-hydroxylase immobilized-enzyme reactor and used to carry out the on-line two-step synthesis of epinephrine from dopamine.	Epinephrine	211-222	phenylethanolamine N-methyltransferase	Homo sapiens	4-13
11830287-7	2002	Orexin-A (1000 nM) significantly increased the release of both epinephrine (E) and norepinephrine (NE) from porcine adrenal medullary cells.	Epinephrine	63-74	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
11872674-2	2002	Epinephrine increases glucose production, lipolysis, and peripheral insulin resistance as well as blood flow and glucose delivery.	Epinephrine	0-11	insulin	Homo sapiens	68-75
11872674-11	2002	Thus, systemic but not local propranolol prevents a decrease in forearm glucose extraction during hypoglycemia, suggesting that epinephrine increases peripheral muscular insulin resistance through systemic effects.	Epinephrine	128-139	insulin	Homo sapiens	170-177
11842069-4	2002	This suppression of glucose uptake by epinephrine was accompanied by an increase in the intracellular concentration of glucose 6-phosphate and a decrease in insulin-receptor substrate-1-associated phosphatidylinositol 3-kinase (IRS-1/PI3-kinase) activity.	Epinephrine	38-49	insulin receptor substrate 1	Rattus norvegicus	228-233
11872654-12	2002	We conclude that 1) caffeine impairs insulin-stimulated glucose uptake and GS activity in rested and exercised human skeletal muscle; 2) caffeine-induced impairment of insulin-stimulated muscle glucose uptake and downregulation of GS activity are not accompanied by alterations in IRTK, PI 3-kinase, PKB/Akt, or GSK-3alpha but may be associated with increases in epinephrine and intramuscular cAMP concentrations; and 3) exercise reduces the detrimental effects of caffeine on insulin action in muscle.	Epinephrine	363-374	insulin	Homo sapiens	168-175
11836295-2	2002	To address this question, we investigated the counterregulatory response to acute insulin-induced hypoglycemia of glucagon, epinephrine, and norepinephrine in eight patients who had undergone transcranial surgery for a craniopharyngioma extending to the hypothalamic region.	Epinephrine	124-135	insulin	Homo sapiens	82-89
11958827-1	2002	Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI).	Epinephrine	141-152	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
11958827-1	2002	Phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine biosynthesis pathway, catalyzes the conversion of norepinephrine (NE) to epinephrine (EPI).	Epinephrine	141-152	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
11864641-2	2002	PACAP (100 nM) increased adrenal epinephrine output.	Epinephrine	33-44	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-5
11807261-1	2002	Phenylethanolamine N-methyltransferase, PNMT, utilizes the methylating cofactor S-adenosyl-L-methionine to catalyse the synthesis of adrenaline.	Epinephrine	133-143	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
11807261-1	2002	Phenylethanolamine N-methyltransferase, PNMT, utilizes the methylating cofactor S-adenosyl-L-methionine to catalyse the synthesis of adrenaline.	Epinephrine	133-143	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
11815511-14	2002	CONCLUSIONS: Caffeine can decrease insulin sensitivity in healthy humans, possibly as a result of elevated plasma epinephrine levels.	Epinephrine	114-125	insulin	Homo sapiens	35-42
11805199-3	2002	Thus, in the present report, we provide evidence that measurement of adrenochrome cannot be used as an index of reactive oxygen species generated during CYP-mediated metabolism of xenobiotics because adrenochrome and its precursor, epinephrine, interact with the CYP enzyme system as substrates and inhibitors.	Epinephrine	232-243	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	153-156
11805199-1	2002	The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine.	Epinephrine	40-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	215-230
11805199-1	2002	The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine.	Epinephrine	40-51	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	232-235
11931349-0	2002	Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-stimulated cyclic AMP synthesis in rat cerebral cortical slices: interaction with noradrenaline, adrenaline, and forskolin.	Epinephrine	170-180	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
11931349-4	2002	Combination of PACAP38, PACAP27 (each at 0.1 microM) and VIP (1 microM) with adrenaline or noradrenaline resulted in most cases in additive effects, with some supraadditive (PACAP27 plus adrenaline) or subadditive (PACAP38 or VIP plus noradrenaline) fluctuations.	Epinephrine	77-87	vasoactive intestinal peptide	Rattus norvegicus	57-60
11931349-4	2002	Combination of PACAP38, PACAP27 (each at 0.1 microM) and VIP (1 microM) with adrenaline or noradrenaline resulted in most cases in additive effects, with some supraadditive (PACAP27 plus adrenaline) or subadditive (PACAP38 or VIP plus noradrenaline) fluctuations.	Epinephrine	77-87	vasoactive intestinal peptide	Rattus norvegicus	226-229
11805199-3	2002	Thus, in the present report, we provide evidence that measurement of adrenochrome cannot be used as an index of reactive oxygen species generated during CYP-mediated metabolism of xenobiotics because adrenochrome and its precursor, epinephrine, interact with the CYP enzyme system as substrates and inhibitors.	Epinephrine	232-243	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	263-266
11867940-3	2002	Since eating behavior disturbances and increased peripheral basal sympathetic activity have been reported in obese subjects, the present study investigated allopregnanolone and catecholamine (epinephrine and norepinephrine) responses to corticotropin-releasing hormone (CRH) in obese subjects.	Epinephrine	192-203	corticotropin releasing hormone	Homo sapiens	237-268
11809916-9	2002	Furthermore, the peak epinephrine to norepinephrine ratio appearing between P7 and P10 in the normoxic offspring was absent in the hypoxic offspring.	Epinephrine	22-33	solute carrier family 10, member 7	Rattus norvegicus	76-86
12234100-4	2002	Adrenaline reduced in a similar proportion the secretion of both hepatic lipase and albumin.	Epinephrine	0-10	lipase C, hepatic type	Rattus norvegicus	65-79
12210722-3	2002	Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of these biogenic amines (dopamine (DA), norepinephrine (NE), and epinephrine (EPI)).	Epinephrine	123-134	tyrosine hydroxylase	Mus musculus	0-20
12182236-7	2002	Insulin-induced hypoglycemia resulted in a significant rise in the mean plasma ACTH levels from 10 +/- 1 pg/ml (domperidone) and 11 +/- 1 pg/ml (controls) to 148 +/- 19 pg/ml (domperidone) and 139 +/- 12 pg/ml (controls) at 45 min (p &lt; 0.001), in plasma cortisol from 407 +/- 62 nmol/l (domperidone) and 391 +/- 42 nmol/l (controls) to 925 +/- 60 nmol/l (domperidone) and 810 +/- 52 nmol/l (controls) at 60 min (p &lt; 0.001), and in plasma epinephrine from 40 +/- 26 pg/ml (domperidone) and 16 +/- 3 pg/ml (controls) to 274 +/- 55 pg/ml (domperidone) and 352 +/- 61 pg/ml (controls) at 30 min; (p &lt; 0.001).	Epinephrine	444-455	proopiomelanocortin	Homo sapiens	79-83
11756684-8	2002	Thus, PACAP is needed to couple epinephrine biosynthesis to secretion during metabolic stress.	Epinephrine	32-43	adenylate cyclase activating polypeptide 1	Mus musculus	6-11
12210722-3	2002	Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of these biogenic amines (dopamine (DA), norepinephrine (NE), and epinephrine (EPI)).	Epinephrine	123-134	tyrosine hydroxylase	Mus musculus	22-24
11786596-6	2002	Furthermore, we noted a large range of leptin response to epinephrine among our subjects, especially in obese women (from -12 to -570 ng/mL per 60 minutes).	Epinephrine	58-69	leptin	Homo sapiens	39-45
11752134-2	2002	In megakaryocyte-like human erythroleukemia (HEL) cells, ERK2 was found to be predominantly expressed and strongly activated by prostaglandin (PG) E(2), thrombin, and epinephrine.	Epinephrine	167-178	mitogen-activated protein kinase 1	Homo sapiens	57-61
12815293-3	2002	Plasma membrane fluidity, measured by fluorescence polarization of DPH incorporated into lipid bilayer and superoxide dismutase (SOD) activity, determined by epinephrine method, showed significant decrease but per cent apoptotic cells, as determined by annexin-V and TUNEL methods, were found increased by two folds after radiotherapy.	Epinephrine	158-169	superoxide dismutase 1	Homo sapiens	107-127
12815293-3	2002	Plasma membrane fluidity, measured by fluorescence polarization of DPH incorporated into lipid bilayer and superoxide dismutase (SOD) activity, determined by epinephrine method, showed significant decrease but per cent apoptotic cells, as determined by annexin-V and TUNEL methods, were found increased by two folds after radiotherapy.	Epinephrine	158-169	superoxide dismutase 1	Homo sapiens	129-132
12399950-9	2002	On the ultrastructural level, chromaffin cells in saline-treated CRHR1 null mice exhibited a marked depletion in epinephrine-storing secretory granules that was not completely normalized by ACTH-treatment.	Epinephrine	113-124	corticotropin releasing hormone receptor 1	Mus musculus	65-70
12399950-10	2002	In conclusion, CRHR1 is required for a normal chromaffin cell structure and function and deletion of this gene is associated with a significant impairment of epinephrine biosynthesis.	Epinephrine	158-169	corticotropin releasing hormone receptor 1	Mus musculus	15-20
11786596-0	2002	Plasma leptin response to an epinephrine infusion in lean and obese women.	Epinephrine	29-40	leptin	Homo sapiens	7-13
11786596-1	2002	OBJECTIVE: Because leptin production by adipose tissue is under hormonal control, we examined the impact of epinephrine administration on plasma leptin concentrations.	Epinephrine	108-119	leptin	Homo sapiens	145-151
11786596-8	2002	DISCUSSION: Results of this study indicate that leptin levels decrease after epinephrine administration in both lean and obese premenopausal women.	Epinephrine	77-88	leptin	Homo sapiens	48-54
11786596-4	2002	RESULTS: In both lean and obese individuals, plasma leptin was significantly reduced by epinephrine (p &lt; 0.0001).	Epinephrine	88-99	leptin	Homo sapiens	52-58
11755955-5	2001	The effect of epinephrine coincided with increased phosphorylation of p38MAPK and cPLA(2) and with arachidonic acid (AA) release from platelet membrane.	Epinephrine	14-25	mitogen-activated protein kinase 14	Homo sapiens	70-77
11795485-2	2001	In this study, the effects of insulin, epinephrine, growth hormone or dexamethasone on the expression of leptin was examined in mouse primary adipocytes.	Epinephrine	39-50	leptin	Mus musculus	105-111
11884023-4	2001	CD4+ and CD8+ lymphocytes were incubated with catecholamines, interleukin 1beta (IL-1beta) and interleukin 2 (IL-2) for 6-72 h. The results demonstrate declining beta2R numbers on CD4+ and CD8+ lymphocytes in vitro augmented by epinephrine.	Epinephrine	228-239	adrenoceptor beta 2	Homo sapiens	162-168
11755955-0	2001	Epinephrine--via activation of p38-MAPK--abolishes the effect of aspirin on platelet deposition to collagen.	Epinephrine	0-11	mitogen-activated protein kinase 14	Homo sapiens	31-34
11755955-5	2001	The effect of epinephrine coincided with increased phosphorylation of p38MAPK and cPLA(2) and with arachidonic acid (AA) release from platelet membrane.	Epinephrine	14-25	phospholipase A2 group IVA	Homo sapiens	82-89
11755955-6	2001	We conclude that epinephrine enhanced platelet deposition on collagen in aspirinised PRP via a mechanism dependent on both free AA in platelet cytosol (released by cPLA(2)) and p38MAPK.	Epinephrine	17-28	complement component 4 binding protein alpha	Homo sapiens	85-88
11755955-6	2001	We conclude that epinephrine enhanced platelet deposition on collagen in aspirinised PRP via a mechanism dependent on both free AA in platelet cytosol (released by cPLA(2)) and p38MAPK.	Epinephrine	17-28	phospholipase A2 group IVA	Homo sapiens	164-171
11755955-6	2001	We conclude that epinephrine enhanced platelet deposition on collagen in aspirinised PRP via a mechanism dependent on both free AA in platelet cytosol (released by cPLA(2)) and p38MAPK.	Epinephrine	17-28	mitogen-activated protein kinase 14	Homo sapiens	177-184
11899430-0	2001	Adrenaline suppression of the macrophage nitric oxide response to lipopolysaccharide is associated with differential regulation of tumour necrosis factor-alpha and interleukin-10.	Epinephrine	0-10	interleukin 10	Mus musculus	164-178
11739254-10	2001	Locally administered gastrin-17 and sulfated cholecystokinin-8 mobilized histamine as did pituitary adenylate cyclase-activating peptide-27, vasoactive intestinal peptide, peptide YY, met-enkephalin, endothelin and noradrenaline, adrenaline and isoprenaline.	Epinephrine	218-228	gastrin	Rattus norvegicus	21-28
11739254-12	2001	While gastrin, sulfated-cholecystokinin-8, met-enkephalin and isoprenaline induced a sustained elevation of the submucosal histamine concentration, endothelin, peptide YY, pituitary adenylate cyclase activating peptide, vasoactive intestinal peptide, noradrenaline and adrenaline induced a transient elevation.	Epinephrine	254-264	gastrin	Rattus norvegicus	6-13
11899430-8	2001	Furthermore, we demonstrated that exogenous TNF-alpha, at a dose range of 1.9-50 ng per ml, also restored the nitrite response to LPS in the presence of adrenaline.	Epinephrine	153-163	tumor necrosis factor	Mus musculus	44-53
11899430-3	2001	We have now extended these studies to examine the effects of adrenaline on the production of tumour necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10).	Epinephrine	61-71	tumor necrosis factor	Mus musculus	123-132
11899430-10	2001	Finally, we also observed that the M phi-activating cytokine, interferon-gamma (IFN-gamma), attenuated the inhibitory effect of adrenaline on the LPS NO response.	Epinephrine	128-138	interferon gamma	Mus musculus	62-78
11899430-10	2001	Finally, we also observed that the M phi-activating cytokine, interferon-gamma (IFN-gamma), attenuated the inhibitory effect of adrenaline on the LPS NO response.	Epinephrine	128-138	interferon gamma	Mus musculus	80-89
11899430-3	2001	We have now extended these studies to examine the effects of adrenaline on the production of tumour necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10).	Epinephrine	61-71	interleukin 10	Mus musculus	138-152
11899430-3	2001	We have now extended these studies to examine the effects of adrenaline on the production of tumour necrosis factor alpha (TNF-alpha) and interleukin-10 (IL-10).	Epinephrine	61-71	interleukin 10	Mus musculus	154-159
11742286-0	2001	Epinephrine for the out-of-hospital (first-aid) treatment of anaphylaxis in infants: is the ampule/syringe/needle method practical?	Epinephrine	0-11	activation induced cytidine deaminase	Homo sapiens	43-46
11899430-6	2001	In order to determine any functional consequence of adrenaline-mediated IL-10 augmentation on NO production, M phi s were stimulated with LPS and specific neutralizing anti-IL-10 antibodies were added to the cultures.	Epinephrine	52-62	interleukin 10	Mus musculus	72-77
11804390-3	2001	All the compounds tested in human PRP showed significant inhibition of secondary aggregation induced by adrenaline (epinephrine), suggesting that the antiplatelet effect of these compounds is mainly due to an inhibitory effect on thromboxane formation.	Epinephrine	104-114	complement component 4 binding protein alpha	Homo sapiens	34-37
11804390-3	2001	All the compounds tested in human PRP showed significant inhibition of secondary aggregation induced by adrenaline (epinephrine), suggesting that the antiplatelet effect of these compounds is mainly due to an inhibitory effect on thromboxane formation.	Epinephrine	116-127	complement component 4 binding protein alpha	Homo sapiens	34-37
11722114-4	2001	The selective targeting of PAR1 enables aprotinin to protect platelets from unwanted activation by thrombin generated during CPB surgery (consistent with a role in platelet-preservation), while permitting the participation of platelets in the formation of hemostatic plugs at wound and suture sites, where collagen, ADP, and epinephrine are most likely to be expressed.	Epinephrine	325-336	coagulation factor II thrombin receptor	Homo sapiens	27-31
11728526-3	2001	They were more inhibitory to epinephrine-induced aggregation (IC(50); 3.4 and 1.7 microM of YS-49, and 6.0 and 6.3 microM of YS-51 to human and rat platelets, respectively) than ADP- or collagen-induced aggregation.	Epinephrine	29-40	seminal vesicle secretory protein 4	Rattus norvegicus	178-182
11735092-9	2001	Decline in vWF (area under the curve) was associated with decrease in epinephrine (r =.46, P =.004) and with screening systolic BP (r =.45, P =.004).	Epinephrine	70-81	von Willebrand factor	Homo sapiens	11-14
11641129-2	2001	Infusion of PACAP (100 nM) increased adrenal epinephrine and norepinephrine output.	Epinephrine	45-56	adenylate cyclase activating polypeptide 1	Rattus norvegicus	12-17
11568154-8	2001	Plasma epinephrine correlated negatively with the percentage of circulating CD8+ T cells producing IL-2, whereas peak IL-6 correlated with the percentage of CD8+ IL-4-producing T cells in the circulation.	Epinephrine	7-18	CD8a molecule	Homo sapiens	76-79
11711504-4	2001	Plasma epinephrine and glucose concentrations significantly increased 30 and 60 minutes after intracerebroventricular injection of CART 55-102 (control versus 60 minutes for epinephrine, 77.0+/-62.4 versus 1067.5+/-329.3 pg/mL, P&lt;0.01; for glucose, 6.25+/-0.33 versus 11.57+/-0.93 mmol/L, P&lt;0.01).	Epinephrine	7-18	CART prepropeptide	Homo sapiens	131-135
11711504-4	2001	Plasma epinephrine and glucose concentrations significantly increased 30 and 60 minutes after intracerebroventricular injection of CART 55-102 (control versus 60 minutes for epinephrine, 77.0+/-62.4 versus 1067.5+/-329.3 pg/mL, P&lt;0.01; for glucose, 6.25+/-0.33 versus 11.57+/-0.93 mmol/L, P&lt;0.01).	Epinephrine	174-185	CART prepropeptide	Homo sapiens	131-135
11691879-16	2001	In conclusion, training increased the amount of HSL and the sensitivity of HSL to stimulation by adrenaline in intra-abdominal adipose tissue, the extent of the change differing between anatomical locations.	Epinephrine	97-107	lipase E, hormone sensitive type	Rattus norvegicus	75-78
11691879-17	2001	In contrast, in skeletal muscle the amount of HSL was unchanged and its sensitivity to stimulation by adrenaline reduced after training.	Epinephrine	102-112	lipase E, hormone sensitive type	Rattus norvegicus	46-49
11697744-10	2001	Thiopental appears to enhance ADP- and epinephrine-induced secondary platelet aggregation by increasing AA release during primary aggregation, possibly by the activation of phospholipase A2.	Epinephrine	39-50	phospholipase A2 group IB	Homo sapiens	173-189
11710758-5	2001	Urinary epinephrine and norepinephrine excretion was significantly higher in the LPD high-sucrose group than in the NPD and LPD low-sucrose groups, and there was a significant positive correlation between urinary norepinephrine excretion and systolic blood pressure.	Epinephrine	8-19	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	81-84
11710758-5	2001	Urinary epinephrine and norepinephrine excretion was significantly higher in the LPD high-sucrose group than in the NPD and LPD low-sucrose groups, and there was a significant positive correlation between urinary norepinephrine excretion and systolic blood pressure.	Epinephrine	8-19	acyl-CoA synthetase bubblegum family member 1	Rattus norvegicus	124-127
11568154-8	2001	Plasma epinephrine correlated negatively with the percentage of circulating CD8+ T cells producing IL-2, whereas peak IL-6 correlated with the percentage of CD8+ IL-4-producing T cells in the circulation.	Epinephrine	7-18	interleukin 2	Homo sapiens	99-103
11585676-2	2001	The beta-AR signal system is one of the most powerful regulators of cardiac function, mediated by the effects of the sympathetic transmitters epinephrine and norepinephrine.	Epinephrine	142-153	adrenergic receptor, beta 1	Mus musculus	4-11
11595779-5	2001	RESULTS: Our results show that patients with the leptin gene mutation (both the homozygous and heterozygous patients) had significantly higher ADP-induced (78.3 +/- 3.4% vs. 57.9 +/- 9.3%, p = 0.001), collagen-induced (78.1 +/- 2.9% vs. 56.7 +/- 9.3%, p = 0.007), and epinephrine-induced (76.5 +/- 9.2% vs. 59.5 +/- 7.70%, p = 0.003) platelet aggregation compared with controls.	Epinephrine	268-279	leptin	Homo sapiens	49-55
11719173-5	2001	In stepwise multiple regression analysis, maximum IL-8 values were significantly correlated with maximum TNF-alpha values within post-ROSC 24 h, with the total dose of administered epinephrine and with peripheral neutrophil counts.	Epinephrine	181-192	C-X-C motif chemokine ligand 8	Homo sapiens	50-54
11719173-6	2001	It is especially noteworthy that the total dose of epinephrine administered during and after resuscitation markedly influenced the elevation of serum IL-8 after ROSC.	Epinephrine	51-62	C-X-C motif chemokine ligand 8	Homo sapiens	150-154
11719173-7	2001	The increases in serum IL-8 induced by excessive administration of epinephrine might be harmful in the ROSC-patients resuscitated after CPA.	Epinephrine	67-78	C-X-C motif chemokine ligand 8	Homo sapiens	23-27
11562427-6	2001	(-)-Epinephrine yielded almost similar maximal [(35)S]GTP gamma S binding responses, but its potency was decreased 22- to 150-fold at the -3 Glu containing mutant G(alpha o) proteins compared with those mutants containing a Gly.	Epinephrine	0-15	G protein subunit alpha o1	Homo sapiens	163-172
11570851-4	2001	Recombinant catechol-O-methyltransferase, in the bacterial soluble fraction, exhibited the same affinity for adrenaline as rat liver soluble catechol-O-methyltransferase (K(m) 428 [246, 609] microM and 531 [330, 732] microM, respectively), as well as the same affinity for the methyl donor, S-adenosyl-l-methionine (K(m) 27 [9, 45] microM and 38 [21, 55] microM, respectively).	Epinephrine	109-119	catechol-O-methyltransferase	Rattus norvegicus	12-40
11591352-0	2001	Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.	Epinephrine	12-22	phenylethanolamine N-methyltransferase	Homo sapiens	86-90
11591352-0	2001	Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT.	Epinephrine	55-65	phenylethanolamine N-methyltransferase	Homo sapiens	86-90
11591352-2	2001	Ideally, a chemical is required that crosses the blood-brain barrier, potently inhibits the adrenaline-synthesizing enzyme PNMT, and does not affect other catecholamine processes.	Epinephrine	92-102	phenylethanolamine N-methyltransferase	Homo sapiens	123-127
11514309-1	2001	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that synthesizes epinephrine from norepinephrine.	Epinephrine	77-88	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
11591352-11	2001	The proposed evolutionary pathway implies that adrenaline, the product of PNMT catalysis, is a relative newcomer in the catecholamine family.	Epinephrine	47-57	phenylethanolamine N-methyltransferase	Homo sapiens	74-78
11591352-12	2001	The PNMT structure reported here enables the design of potent and selective inhibitors with which to characterize the role of adrenaline in the CNS.	Epinephrine	126-136	phenylethanolamine N-methyltransferase	Homo sapiens	4-8
11502577-12	2001	However, epinephrine induced a small increase in IL-6 and may, therefore, partly influence the plasma levels of IL-6 during exercise.	Epinephrine	9-20	interleukin 6	Homo sapiens	112-116
11502577-7	2001	The increase in plasma IL-6 during epinephrine infusion was only sixfold, with the peak value at 1 h after infusion.	Epinephrine	35-46	interleukin 6	Homo sapiens	23-27
11502577-12	2001	However, epinephrine induced a small increase in IL-6 and may, therefore, partly influence the plasma levels of IL-6 during exercise.	Epinephrine	9-20	interleukin 6	Homo sapiens	49-53
11514309-1	2001	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that synthesizes epinephrine from norepinephrine.	Epinephrine	77-88	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
11719160-12	2001	The enhanced mixed venous hypercarbic acidosis in epinephrine-treated animals may support the argument against repeated or high dose epinephrine administration during hypothermic CPR.	Epinephrine	50-61	cytochrome p450 oxidoreductase	Sus scrofa	179-182
11524349-7	2001	Ninety seconds after the first drug administration, epinephrine increased coronary perfusion pressure significantly less than vasopressin in control animals without epidural block (42 +/- 2 vs 57 +/- 5 mm Hg, P &lt; 0.05), but comparably to vasopressin after epidural block (45 +/- 4 vs 48 +/- 6 mm Hg).	Epinephrine	52-63	vasopressin	Sus scrofa	241-252
11517280-4	2001	Epinephrine, which induces hyperalgesia by direct action at beta(2)-adrenergic receptors on primary afferent nociceptors, stimulated phosphorylation of ERK1/2 in cultured rat dorsal root ganglion cells.	Epinephrine	0-11	mitogen activated protein kinase 3	Rattus norvegicus	152-158
11555177-4	2001	The present study shows that the stimulation of cultured pinealocytes by 1 microM epinephrine (an alpha- and beta-adrenergic agonist) for 2 h increased the number of c-fos immunoreactive (IR) cells, and that this stimulatory effect was abolished by adding 10 microM prazosin (an alpha-adrenergic antagonist) to the culture medium.	Epinephrine	82-93	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	166-171
11522288-2	2001	We found that mouse RGS16, when expressed in HEK293T cells, is phosphorylated constitutively at serine 194 based on in vivo orthophosphate labeling experiments, while serine 53 is phosphorylated in a ligand-dependent manner upon stimulation by epinephrine in cells expressing the alpha2A adrenergic receptor.	Epinephrine	244-255	regulator of G-protein signaling 16	Mus musculus	20-25
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Epinephrine	30-40	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	180-188
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Epinephrine	30-40	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	190-198
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Epinephrine	30-40	adrenergic receptor, alpha 2a	Mus musculus	236-244
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Epinephrine	30-40	adrenergic receptor, alpha 2b	Mus musculus	246-254
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Epinephrine	30-40	adrenergic receptor, alpha 2c	Mus musculus	256-264
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Epinephrine	30-40	hemoglobin, beta adult major chain	Mus musculus	292-298
11677796-2	2001	The endogenous catecholamines adrenaline and noradrenaline mediate their biological actions via activation of nine different adrenergic receptor subtypes, three alpha 1-receptors (alpha 1A, alpha 1B, alpha 1D), three alpha 2-receptors (alpha 2A, alpha 2B, alpha 2C) and three beta-receptors (beta 1, beta 2, beta 3).	Epinephrine	30-40	hemoglobin, beta adult minor chain	Mus musculus	300-314
11489301-6	2001	Biological support to these in vitro data comes from the observation that the relaxation of an adrenaline-contracted aortic ring produced via addition of NO is concomitant with peak 1 at +550 mV.	Epinephrine	95-105	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	177-183
11447076-2	2001	We previously reported that the Pl(A2) allele was associated with increased platelet aggregability, as indicated by lower epinephrine threshold concentrations.	Epinephrine	122-133	phospholipase A2 group IIA	Homo sapiens	32-37
11484145-0	2001	[Suture of skin lacerations using LAT gel (lidocaine, adrenaline, tetracaine)].	Epinephrine	54-64	linker for activation of T cells	Homo sapiens	34-37
11484145-12	2001	of LAT was used in our study (consisting in 12.3 mg of Lidocaine, 8.2 mg of Tetracaine an 0.82 mg of Adrenalin).	Epinephrine	101-110	linker for activation of T cells	Homo sapiens	3-6
11719151-1	2001	BACKGROUND: Intravenous administration of vasopressin during cardiopulmonary resuscitation (CPR) has been shown to be more effective than optimal doses of epinephrine.	Epinephrine	155-166	vasopressin	Sus scrofa	42-53
11448853-1	2001	We elucidated the functional contribution of voltage-dependent calcium channels (VDCCs) and adenylate cyclase to epinephrine (Epi) and norepinephrine (NE) secretion induced by pituitary adenylate cyclase-activating polypeptide (PACAP) in the isolated perfused rat adrenal gland.	Epinephrine	113-124	adenylate cyclase activating polypeptide 1	Rattus norvegicus	176-226
11457773-2	2001	We hypothesized that the same would be true in women, that reduced insulin sensitivity would be directly related to the rise in plasma epinephrine concentrations at altitude, and that the addition of alpha-adrenergic blockade would potentiate the reduction.	Epinephrine	135-146	insulin	Homo sapiens	67-74
11520900-4	2001	Both RGS1 and RGS16 reduced the potency of the alpha2A-adrenoreceptor agonist adrenaline by some 10-fold.	Epinephrine	78-88	regulator of G protein signaling 1	Homo sapiens	5-9
11520900-4	2001	Both RGS1 and RGS16 reduced the potency of the alpha2A-adrenoreceptor agonist adrenaline by some 10-fold.	Epinephrine	78-88	regulator of G protein signaling 16	Homo sapiens	14-19
11520900-4	2001	Both RGS1 and RGS16 reduced the potency of the alpha2A-adrenoreceptor agonist adrenaline by some 10-fold.	Epinephrine	78-88	adrenoceptor alpha 2A	Homo sapiens	47-69
11520900-6	2001	Each of these RGS proteins altered the intrinsic activity of both UK14304 and oxymetazoline relative to adrenaline.	Epinephrine	104-114	paired like homeodomain 2	Homo sapiens	14-17
11447076-8	2001	The fibrinogen effect was genotype specific, however, in that the increase in platelet aggregability with higher fibrinogen was present for the Pl(A1/A1) genotype (P=0.0005 and P=0.03 for epinephrine- and ADP-induced aggregation, respectively) but not for the Pl(A2)-positive genotype (P&gt;0.90).	Epinephrine	188-199	fibrinogen beta chain	Homo sapiens	4-14
11447076-8	2001	The fibrinogen effect was genotype specific, however, in that the increase in platelet aggregability with higher fibrinogen was present for the Pl(A1/A1) genotype (P=0.0005 and P=0.03 for epinephrine- and ADP-induced aggregation, respectively) but not for the Pl(A2)-positive genotype (P&gt;0.90).	Epinephrine	188-199	POU class 2 homeobox 3	Homo sapiens	144-152
11447076-7	2001	Higher fibrinogen levels were associated with increased epinephrine-induced aggregation (P=0.002) and a trend for ADP-induced aggregation (P=0.07).	Epinephrine	56-67	fibrinogen beta chain	Homo sapiens	7-17
11433007-0	2001	Adrenaline increases skeletal muscle glycogenolysis, pyruvate dehydrogenase activation and carbohydrate oxidation during moderate exercise in humans.	Epinephrine	0-10	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	53-75
11413119-5	2001	RESULTS: COMP(art) was significantly increased in cirrhotic patients compared with controls (1.32 v 1.06 ml/mm Hg; p&lt; 0.05) and inversely related to plasma adrenaline levels (r=-0.53; p&lt;0.02) but positively related to circulating levels of CGRP (r=0.58; p&lt;0.01).	Epinephrine	159-169	calcitonin related polypeptide alpha	Homo sapiens	246-250
11431462-0	2001	Epinephrine-induced increases in [Ca2+](in) and KCl-coupled fluid absorption in bovine RPE.	Epinephrine	0-11	ribulose-phosphate 3-epimerase	Bos taurus	87-90
11431462-2	2001	METHODS: Epinephrine-induced changes in RPE [Ca2+](in) levels were monitored with the ratioing dye fura-2.	Epinephrine	9-20	ribulose-phosphate 3-epimerase	Bos taurus	40-43
11431462-9	2001	CONCLUSIONS: Epinephrine increased fluid absorption across bovine RPE by activating apical membrane alpha(1)-adrenergic receptors, increasing [Ca2+](in), and stimulating bumetanide-sensitive Na,K,2Cl uptake at the apical membrane and KCl efflux at the basolateral membrane.	Epinephrine	13-24	ribulose-phosphate 3-epimerase	Bos taurus	66-69
11433007-13	2001	The data demonstrate that elevated plasma adrenaline levels during moderate exercise in untrained men increase skeletal muscle glycogen breakdown and PDH activation, which results in greater carbohydrate oxidation.	Epinephrine	42-52	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	150-153
11411733-10	2001	These data suggest that insulin may modify the glycemic response to epinephrine in a potentially favorable direction and indicate some lag time before epinephrine gains effect.	Epinephrine	68-79	insulin	Homo sapiens	24-31
11394742-5	2001	A novel clinical test involving an epinephrine challenge in the decedent"s mother implicated a potential defect in the phase 3 potassium current encoded by the gene KVLQT1.	Epinephrine	35-46	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	165-171
11389023-8	2001	The combination of JAQ1 and adrenaline or ADP, but not serotonin, resulted in alpha(IIb)beta(3)-dependent aggregation that occurred without intracellular calcium mobilization and shape change in the absence of Galphaq or the P2Y(1) receptor.	Epinephrine	28-38	purinergic receptor P2Y, G-protein coupled 1	Mus musculus	225-240
11411733-11	2001	Subjects who are insulin sensitive and have low blood pressure and resting epinephrine levels seem to be less prone to hyperglycemia induced by epinephrine.	Epinephrine	75-86	insulin	Homo sapiens	17-24
11375813-2	2001	We recently showed that endotracheal adrenaline can decrease blood pressure (BP), a detrimental effect presumably mediated by the beta 2-adrenergic receptor unopposed by alpha-adrenergic vasoconstriction.	Epinephrine	37-47	beta-2 adrenergic receptor	Canis lupus familiaris	130-156
11375833-11	2001	We conclude that endogenous vasopressin is an adjunct vasopressor to epinephrine and may serve as a back-up regulator to maintain cardiocirculatory homeostasis.	Epinephrine	69-80	vasopressin	Sus scrofa	28-39
11411733-11	2001	Subjects who are insulin sensitive and have low blood pressure and resting epinephrine levels seem to be less prone to hyperglycemia induced by epinephrine.	Epinephrine	144-155	insulin	Homo sapiens	17-24
11454025-2	2001	In normal male but not female rats, epinephrine-induced mechanical hyperalgesia was antagonized by inhibitors of protein kinase Cepsilon (PKCepsilon), protein kinase A (PKA) and nitric oxide synthetase (NOS).	Epinephrine	36-47	protein kinase C, epsilon	Rattus norvegicus	113-136
11454025-2	2001	In normal male but not female rats, epinephrine-induced mechanical hyperalgesia was antagonized by inhibitors of protein kinase Cepsilon (PKCepsilon), protein kinase A (PKA) and nitric oxide synthetase (NOS).	Epinephrine	36-47	protein kinase C, epsilon	Rattus norvegicus	138-148
11454025-2	2001	In normal male but not female rats, epinephrine-induced mechanical hyperalgesia was antagonized by inhibitors of protein kinase Cepsilon (PKCepsilon), protein kinase A (PKA) and nitric oxide synthetase (NOS).	Epinephrine	36-47	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	151-167
11454025-2	2001	In normal male but not female rats, epinephrine-induced mechanical hyperalgesia was antagonized by inhibitors of protein kinase Cepsilon (PKCepsilon), protein kinase A (PKA) and nitric oxide synthetase (NOS).	Epinephrine	36-47	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	169-172
11454025-3	2001	Similarly, in PKCepsilon knockout mice, a contribution of PKCepsilon to epinephrine-dependent mechanical hyperalgesia occurred in males only.	Epinephrine	72-83	protein kinase C, epsilon	Mus musculus	14-24
11454025-3	2001	Similarly, in PKCepsilon knockout mice, a contribution of PKCepsilon to epinephrine-dependent mechanical hyperalgesia occurred in males only.	Epinephrine	72-83	protein kinase C, epsilon	Mus musculus	58-68
11454025-8	2001	These data demonstrate gender differences in PKCepsilon, PKA and NO signalling in epinephrine-induced hyperalgesia which are oestrogen dependent and appear to be exerted at the level of the beta-adrenergic receptor or the G-protein to which it is coupled.	Epinephrine	82-93	protein kinase C, epsilon	Rattus norvegicus	45-55
11454025-8	2001	These data demonstrate gender differences in PKCepsilon, PKA and NO signalling in epinephrine-induced hyperalgesia which are oestrogen dependent and appear to be exerted at the level of the beta-adrenergic receptor or the G-protein to which it is coupled.	Epinephrine	82-93	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	57-60
11322936-6	2001	These effects of epinephrine on the clearance of Ca(2+) from the cytosol of FMLP-activated neutrophils were attenuated by propranolol, and are compatible with enhancement of the activity of the cAMP-dependent Ca(2+) sequestering/resequestering endo-membrane Ca(2+)-ATPase.	Epinephrine	17-28	formyl peptide receptor 1	Homo sapiens	76-80
11344198-1	2001	This study examined the mechanisms linking different biochemical and clinical phenotypes of pheochromocytoma in multiple endocrine neoplasia type 2 (MEN 2) and von Hippel-Lindau (VHL) syndrome to underlying differences in the expression of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis, and of phenylethanolamine N-methyltransferase (PNMT), the enzyme that converts norepinephrine to epinephrine.	Epinephrine	402-413	tyrosine hydroxylase	Homo sapiens	240-260
11426840-3	2001	administered CRF and urocortin (0.5, 1.5 and 3.0 nmol/animal) effectively and dose-dependently elevated plasma levels of adrenaline and noradrenaline, and the effect of urocortin was almost the same as that of CRF.	Epinephrine	121-131	urocortin	Rattus norvegicus	21-30
11426700-3	2001	Optimum pH and optimum temperature values for LPO were determined for ABTS, p-phenylendiamine, catechol, epinephrine, and pyrogallol as substrates, and then Km and Vmax values for the same substrate were obtained by means of Lineweaver-Burk graphics.	Epinephrine	105-116	lactoperoxidase	Bos taurus	46-49
11306720-0	2001	Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine.	Epinephrine	81-92	adrenoceptor alpha 2A	Homo sapiens	41-63
11383713-3	2001	Fusion between either a wt alpha2C AR or a mutant Thr382Lys alpha2C AR and a chimeric Galphaq/il protein displayed robust, transient (-)-adrenaline-mediated Ca2+ responses with similar potencies (pEC50: 7.78 and 7.66) and kinetic properties.	Epinephrine	133-147	adrenoceptor alpha 2C	Homo sapiens	27-37
11383713-3	2001	Fusion between either a wt alpha2C AR or a mutant Thr382Lys alpha2C AR and a chimeric Galphaq/il protein displayed robust, transient (-)-adrenaline-mediated Ca2+ responses with similar potencies (pEC50: 7.78 and 7.66) and kinetic properties.	Epinephrine	133-147	adrenoceptor alpha 2C	Homo sapiens	60-70
11264240-5	2001	Competition of [(3)H]-RX821002 binding by (-)-adrenaline further indicated that chronic reserpine was associated with up-regulation of the high-affinity state of alpha(2)-adrenoceptors.	Epinephrine	42-56	adrenoceptor alpha 2A	Rattus norvegicus	162-184
11311882-4	2001	Here, we show that leptin transport into the brain is enhanced 2-3-fold by epinephrine and other agents which are more specific for the alpha1 adrenergic receptor.	Epinephrine	75-86	leptin	Homo sapiens	19-25
11311882-10	2001	In conclusion, epinephrine works at an alpha1-like adrenergic, luminal side to enhance the transport of leptin across the BBB.	Epinephrine	15-26	leptin	Homo sapiens	104-110
11311236-4	2001	Stimulation of the cells with epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. The stimulatory effects of epinephrine were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished by propranolol and ICI-118,551 (beta2-AR antagonists).	Epinephrine	30-41	uncoupling protein 3	Homo sapiens	56-60
11311236-4	2001	Stimulation of the cells with epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. The stimulatory effects of epinephrine were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished by propranolol and ICI-118,551 (beta2-AR antagonists).	Epinephrine	30-41	uncoupling protein 2	Homo sapiens	105-109
11311236-4	2001	Stimulation of the cells with epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. The stimulatory effects of epinephrine were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished by propranolol and ICI-118,551 (beta2-AR antagonists).	Epinephrine	30-41	adrenoceptor beta 2	Homo sapiens	292-300
11311236-4	2001	Stimulation of the cells with epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. The stimulatory effects of epinephrine were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished by propranolol and ICI-118,551 (beta2-AR antagonists).	Epinephrine	30-41	adrenoceptor beta 2	Homo sapiens	358-366
11311236-4	2001	Stimulation of the cells with epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. The stimulatory effects of epinephrine were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished by propranolol and ICI-118,551 (beta2-AR antagonists).	Epinephrine	159-170	uncoupling protein 2	Homo sapiens	105-109
11311236-4	2001	Stimulation of the cells with epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. The stimulatory effects of epinephrine were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished by propranolol and ICI-118,551 (beta2-AR antagonists).	Epinephrine	159-170	adrenoceptor beta 2	Homo sapiens	292-300
11311236-4	2001	Stimulation of the cells with epinephrine increased the UCP3 mRNA level transiently at 6 h, and also the UCP2 mRNA level at 6-24 h. The stimulatory effects of epinephrine were also observed in the presence of carbacyclin and 9-cis retinoic acid, and mimicked by isoproterenol and salbutamol (beta2-AR agonists), but abolished by propranolol and ICI-118,551 (beta2-AR antagonists).	Epinephrine	159-170	adrenoceptor beta 2	Homo sapiens	358-366
11247840-1	2001	Simultaneous blockade of systemic AT1 and AT2 receptors or converting enzyme inhibition (CEI) attenuates the hypoglycemia-induced reflex increase of epinephrine (Epi).	Epinephrine	149-160	angiotensin II receptor, type 1a	Rattus norvegicus	34-37
11247840-1	2001	Simultaneous blockade of systemic AT1 and AT2 receptors or converting enzyme inhibition (CEI) attenuates the hypoglycemia-induced reflex increase of epinephrine (Epi).	Epinephrine	149-160	angiotensin II receptor, type 2	Rattus norvegicus	42-45
11247840-1	2001	Simultaneous blockade of systemic AT1 and AT2 receptors or converting enzyme inhibition (CEI) attenuates the hypoglycemia-induced reflex increase of epinephrine (Epi).	Epinephrine	149-160	tissue factor pathway inhibitor	Rattus norvegicus	162-165
11264230-17	2001	From these results, we conclude that KB-R7943 inhibits the adrenaline plus 5-HT induced aggregation of rabbit and human platelets by inhibiting K(+)-dependent Na(+)/Ca(2+) exchange (NCKX).	Epinephrine	59-69	solute carrier family 24 member 1	Homo sapiens	182-186
11456267-5	2001	Phentolamine (an adrenergic alpha-antagonist) plus epinephrine augmented insulin secretion; however, this insulin secretory response was inhibited by heat exposure.	Epinephrine	51-62	LOC105613195	Ovis aries	73-80
11403997-2	2001	In the present study we compared the effect of angiotensin II and angiotensin 1-7 on the concentration of dopamine, serotonin, epinephrine, and norepinephrine and some of their metabolites in the rat hypothalamus, where the levels of angiotensins are particularly high.	Epinephrine	127-138	angiotensinogen	Rattus norvegicus	47-81
11403997-3	2001	Intracerebroventricular injection of angiotensin II, but not angiotensin 1-7, time-dependently elevated the levels of both epinephrine (p &lt; 0.05) and norepinephrine (p &lt; 0.05) in the hypothalamus and both effects could be prevented by intracerebroventricular injection of either AT(1) (candesartan), AT(2) (PD123319) or AT(1-7) (A-779) receptor antagonist.	Epinephrine	123-134	angiotensinogen	Rattus norvegicus	37-51
11373471-7	2001	MEASUREMENTS AND MAIN RESULTS: Epinephrine and norepinephrine increased the production of IL-6 but not of IL-1alpha in normal abdominal skin, and these increases were reversed by a beta-blocker (propranolol hydrochloride) but not an alpha-blocker (phentolamine mesylate).	Epinephrine	31-42	interleukin 6	Mus musculus	90-94
11444425-0	2001	Regulation of insulin-stimulated tyrosine phosphorylation of Shc and Shc/Grb2 association in liver, muscle, and adipose tissue of epinephrine- and streptozotocin-treated rats.	Epinephrine	130-141	growth factor receptor bound protein 2	Rattus norvegicus	73-77
11444425-6	2001	These data suggest that while epinephrine preserves the insulin-induced phosphorylation of Shc and the mitogenic pathway stimulated by Shc-Grb2 association, treatment with streptozotocin leads to a tissue-specific increase in the activity of the initial step that ultimately results in the activation of the Shc/Grb2 mitogenic pathway.	Epinephrine	30-41	growth factor receptor bound protein 2	Rattus norvegicus	139-143
11283248-2	2001	PP1G/RGL has been postulated to play a central role in epinephrine and insulin control of glycogen metabolism via phosphorylation of RGL.	Epinephrine	55-66	protein phosphatase 1 catalytic subunit gamma	Mus musculus	0-4
11325192-2	2001	Several purported agonists, including isoproterenol, epinephrine, norepinephine, dobutamine, salbutamol, and terbutaline, exhibited dual-affinity displacement curves, which is characteristic of agonist binding to betaAR.	Epinephrine	53-64	adrenoceptor beta 2	Homo sapiens	213-219
11266507-3	2001	Here, we show that epinephrine and norepinephrine potentiate ligand-dependent GR transactivation in a hippocampal cell line (HT22) via beta(2)-adrenergic receptors.	Epinephrine	19-30	nuclear receptor subfamily 3 group C member 1	Homo sapiens	78-80
11299318-1	2001	Tyrosine hydroxylase (TH) is the rate-limiting enzyme of dopamine and (nor)adrenaline biosynthesis.	Epinephrine	75-85	tyrosine hydroxylase	Mus musculus	0-20
11299318-1	2001	Tyrosine hydroxylase (TH) is the rate-limiting enzyme of dopamine and (nor)adrenaline biosynthesis.	Epinephrine	75-85	tyrosine hydroxylase	Mus musculus	22-24
11283248-2	2001	PP1G/RGL has been postulated to play a central role in epinephrine and insulin control of glycogen metabolism via phosphorylation of RGL.	Epinephrine	55-66	protein phosphatase 1, regulatory subunit 3A	Mus musculus	5-8
11283248-2	2001	PP1G/RGL has been postulated to play a central role in epinephrine and insulin control of glycogen metabolism via phosphorylation of RGL.	Epinephrine	55-66	protein phosphatase 1, regulatory subunit 3A	Mus musculus	133-136
11239501-4	2001	Treatment with epinephrine (1 microM) rapidly increased ODF and OCIF mRNA levels, which peaked after 0.5 hr of treatment.	Epinephrine	15-26	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	56-59
11239501-4	2001	Treatment with epinephrine (1 microM) rapidly increased ODF and OCIF mRNA levels, which peaked after 0.5 hr of treatment.	Epinephrine	15-26	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	64-68
11239501-3	2001	Using a reverse transcription-polymerase chain reaction approach, we investigated the effect of epinephrine on mRNA levels of ODF and its decoy receptor, osteoclastogenesis inhibitory factor (OCIF), in MC3T3-E1 cells.	Epinephrine	96-107	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	126-129
11239501-3	2001	Using a reverse transcription-polymerase chain reaction approach, we investigated the effect of epinephrine on mRNA levels of ODF and its decoy receptor, osteoclastogenesis inhibitory factor (OCIF), in MC3T3-E1 cells.	Epinephrine	96-107	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	154-190
11239501-5	2001	Epinephrine (1 microM) also increased interleukin (IL)-6, IL-11, and cyclooxygenase (COX)-II mRNA levels, as well as increased prostaglandin E(2) (PGE(2)) accumulation in the culture medium.	Epinephrine	0-11	interleukin 6	Mus musculus	38-56
11239501-3	2001	Using a reverse transcription-polymerase chain reaction approach, we investigated the effect of epinephrine on mRNA levels of ODF and its decoy receptor, osteoclastogenesis inhibitory factor (OCIF), in MC3T3-E1 cells.	Epinephrine	96-107	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	192-196
11239501-5	2001	Epinephrine (1 microM) also increased interleukin (IL)-6, IL-11, and cyclooxygenase (COX)-II mRNA levels, as well as increased prostaglandin E(2) (PGE(2)) accumulation in the culture medium.	Epinephrine	0-11	interleukin 11	Mus musculus	58-63
11239501-7	2001	However, increases in ODF and OCIF mRNA levels by epinephrine were more rapid than those by IL-11, and were not influenced by NS-398 (100 microM; an inhibitor of COX-II), suggesting a direct effect of epinephrine on ODF and OCIF mRNA expressions as well as an indirect effect mediated by IL-11 and PGE(2) production.	Epinephrine	50-61	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	22-25
11239501-7	2001	However, increases in ODF and OCIF mRNA levels by epinephrine were more rapid than those by IL-11, and were not influenced by NS-398 (100 microM; an inhibitor of COX-II), suggesting a direct effect of epinephrine on ODF and OCIF mRNA expressions as well as an indirect effect mediated by IL-11 and PGE(2) production.	Epinephrine	50-61	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	30-34
11239501-8	2001	Epinephrine-induced increases in ODF and OCIF mRNA levels were inhibited by pretreatment with timolol (1 microM; beta-antagonist) and phentolamine (1 microM; alpha-antagonist), respectively.	Epinephrine	0-11	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	33-36
11239501-8	2001	Epinephrine-induced increases in ODF and OCIF mRNA levels were inhibited by pretreatment with timolol (1 microM; beta-antagonist) and phentolamine (1 microM; alpha-antagonist), respectively.	Epinephrine	0-11	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	41-45
11239501-10	2001	The action of isoproterenol, a beta-agonist, was clearly stronger than that of epinephrine, suggesting the importance of the physiological balance between ODF and OCIF productions for osteoclastogenesis.	Epinephrine	79-90	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	155-158
11239501-10	2001	The action of isoproterenol, a beta-agonist, was clearly stronger than that of epinephrine, suggesting the importance of the physiological balance between ODF and OCIF productions for osteoclastogenesis.	Epinephrine	79-90	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	163-167
11172736-0	2001	Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells.	Epinephrine	88-99	interleukin 6	Homo sapiens	31-44
11156884-2	2001	We showed that the P2Y(1) receptor is an essential cofactor in thrombotic states induced by intravenous infusion of collagen and epinephrine.	Epinephrine	129-140	purinergic receptor P2Y, G-protein coupled 1	Mus musculus	19-34
11693770-8	2001	The epinephrine-induced increases in the mean QTc-e and Tcp-e were larger in LQT1 than in LQT2, and were more pronounced when the averaged data were obtained from 24-leads than from 87-leads.	Epinephrine	4-15	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	77-81
11693770-8	2001	The epinephrine-induced increases in the mean QTc-e and Tcp-e were larger in LQT1 than in LQT2, and were more pronounced when the averaged data were obtained from 24-leads than from 87-leads.	Epinephrine	4-15	potassium voltage-gated channel subfamily H member 2	Homo sapiens	90-94
11307824-6	2001	Finally, we provide evidence that secreted ADP, known to play a key role in TRAP-induced irreversible phase of aggregation, was involved in the sustained MLC phosphorylation through Rho-kinase and could be replaced by epinephrine.	Epinephrine	218-229	TRAP	Homo sapiens	76-80
11164826-1	2001	3,4-Dihydroxyphenylglycolaldehyde is the monoamine oxidase-A metabolite of two catecholamine neurotransmitters, epinephrine and norepinephrine.	Epinephrine	112-123	monoamine oxidase A	Rattus norvegicus	41-60
11172736-0	2001	Signal transduction system for interleukin-6 and interleukin-11 synthesis stimulated by epinephrine in human osteoblasts and human osteogenic sarcoma cells.	Epinephrine	88-99	interleukin 11	Homo sapiens	49-63
11172736-2	2001	An increase in IL-6 and IL-11 synthesis in response to epinephrine appeared to be a common feature in osteoblastic cells, but the magnitude of expression was different in these cell lines.	Epinephrine	55-66	interleukin 6	Homo sapiens	15-19
11172736-2	2001	An increase in IL-6 and IL-11 synthesis in response to epinephrine appeared to be a common feature in osteoblastic cells, but the magnitude of expression was different in these cell lines.	Epinephrine	55-66	interleukin 11	Homo sapiens	24-29
11172736-6	2001	The findings of the present study suggest that coinduction of IL-6 and IL-11 in response to epinephrine probably occurs via the PKA and p38 MAPK systems, leading to the transcriptional activation of AP-1 in human osteoblastic cells.	Epinephrine	92-103	interleukin 6	Homo sapiens	62-66
11172736-6	2001	The findings of the present study suggest that coinduction of IL-6 and IL-11 in response to epinephrine probably occurs via the PKA and p38 MAPK systems, leading to the transcriptional activation of AP-1 in human osteoblastic cells.	Epinephrine	92-103	interleukin 11	Homo sapiens	71-76
11172736-6	2001	The findings of the present study suggest that coinduction of IL-6 and IL-11 in response to epinephrine probably occurs via the PKA and p38 MAPK systems, leading to the transcriptional activation of AP-1 in human osteoblastic cells.	Epinephrine	92-103	mitogen-activated protein kinase 14	Homo sapiens	136-139
11216955-11	2001	The TNF-alpha/IL-10 ratio correlated well with plasma epinephrine levels (r = 0.677, p = 0.025), and the level of sTNF-R2 was closely related to LV size.	Epinephrine	54-65	tumor necrosis factor	Homo sapiens	4-13
11246318-13	2001	Epinephrine significantly increased jejunal microvascular blood flow (baseline, 267 +/- 39 perfusion units; maximum value, 443 +/- 35 perfusion units) and mucosal oxygen tension (baseline, 36 +/- 2.0 torr [4.79 +/- 0.27 kPa]; maximum value, 48 +/- 2.8 torr [6.39 +/- 0.37 kPa]) and increased hemoglobin oxygen saturation above baseline.	Epinephrine	0-11	HGB	Sus scrofa	292-302
11216955-11	2001	The TNF-alpha/IL-10 ratio correlated well with plasma epinephrine levels (r = 0.677, p = 0.025), and the level of sTNF-R2 was closely related to LV size.	Epinephrine	54-65	interleukin 10	Homo sapiens	14-19
11175853-2	2001	Here we show that inactivation of the Gas6 gene prevented venous and arterial thrombosis in mice, and protected against fatal collagen/epinephrine-induced thrombo embolism.	Epinephrine	135-146	growth arrest specific 6	Mus musculus	38-42
11168848-6	2001	The activity of phenylethanolamine N-methyltransferase, the enzyme that converts noradrenaline into adrenaline, is stimulated by glucocorticoids, which causes the conversion of noradrenergic to adrenergic chromaffin cells.	Epinephrine	84-94	phenylethanolamine N-methyltransferase	Homo sapiens	16-54
11229419-0	2001	Urinary epinephrine and norepinephrine interrelations with obesity, insulin, and the metabolic syndrome in Hong Kong Chinese.	Epinephrine	8-19	insulin	Homo sapiens	68-75
11353933-14	2001	Epinephrine increased hepatic arterial flow at 0.2 microg kg-1 min-1; dopamine had no effect on hepatic arterial flow at any dose.	Epinephrine	0-11	CD59 molecule (CD59 blood group)	Homo sapiens	63-68
11163531-0	2001	Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells.	Epinephrine	0-11	superoxide dismutase 1	Homo sapiens	24-44
11141309-1	2001	Norepinephrine is N-methylated to epinephrine by the catalytic effect of the terminal enzyme in catecholamine biosynthesis, phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	3-14	phenylethanolamine N-methyltransferase	Homo sapiens	124-162
11141309-1	2001	Norepinephrine is N-methylated to epinephrine by the catalytic effect of the terminal enzyme in catecholamine biosynthesis, phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	3-14	phenylethanolamine N-methyltransferase	Homo sapiens	164-168
11151063-8	2001	We found that physiologic concentrations of estrogen strongly and significantly inhibited the aggregation of PlA1/A2 platelets (P&lt;.005 for epinephrine and P&lt;.05 for adenosine diphosphate, induced aggregation, respectively) in both men and women.	Epinephrine	142-153	POU class 2 homeobox 3	Homo sapiens	109-113
11899288-5	2001	IgE-mediated allergic patients should be equipped with education, an emergency action plan, and injectable epinephrine to aggressively treat food-induced reactions and prevent fatalities.	Epinephrine	107-118	immunoglobulin heavy constant epsilon	Homo sapiens	0-3
11207028-0	2001	Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline.	Epinephrine	79-89	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	14-33
11163531-8	2001	Treatment of cells with the beta-blocker atenolol also blocked the upregulation of SOD (p &lt;.05 vs. epinephrine alone).	Epinephrine	102-113	superoxide dismutase 1	Homo sapiens	83-86
11163531-9	2001	These observations suggest that epinephrine via beta(1)-adrenoceptor activation causes superoxide anion generation, and the superoxide subsequently upregulates the endogenous antioxidant species SOD.	Epinephrine	32-43	adrenoceptor beta 1	Homo sapiens	48-68
11163531-9	2001	These observations suggest that epinephrine via beta(1)-adrenoceptor activation causes superoxide anion generation, and the superoxide subsequently upregulates the endogenous antioxidant species SOD.	Epinephrine	32-43	superoxide dismutase 1	Homo sapiens	195-198
11258636-3	2001	At the point of exhaustion significantly higher values for norepinephrine and epinephrine were observed in ST2 than in ST1.	Epinephrine	62-73	ST2	Homo sapiens	107-110
11258636-3	2001	At the point of exhaustion significantly higher values for norepinephrine and epinephrine were observed in ST2 than in ST1.	Epinephrine	62-73	syndecan binding protein	Homo sapiens	119-122
11179598-3	2001	Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels.	Epinephrine	112-123	corticotropin releasing hormone	Homo sapiens	12-15
11133901-10	2001	A more dramatic effect of both altitude ( upward arrow 104% placebo vs. 95% blocked) and blockade ( upward arrow 50% sea level vs. 44% altitude) was observed for plasma epinephrine levels during exercise.	Epinephrine	169-180	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	117-120
11244495-1	2001	Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline.	Epinephrine	122-132	catechol-O-methyltransferase	Homo sapiens	0-28
11244495-1	2001	Catechol-O-methyltransferase (COMT) is a major component of the metabolic pathways of neurotransmitters such as dopamine, adrenaline, and noradrenaline.	Epinephrine	122-132	catechol-O-methyltransferase	Homo sapiens	30-34
11179598-1	2001	Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.	Epinephrine	124-135	gastrin releasing peptide	Homo sapiens	26-34
11179598-1	2001	Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.	Epinephrine	124-135	gastrin releasing peptide	Homo sapiens	36-38
11179598-3	2001	Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels.	Epinephrine	112-123	gastrin releasing peptide	Homo sapiens	80-82
11153614-8	2000	MEASUREMENTS AND MAIN RESULTS: Mean +/- SEM coronary perfusion pressure, before and 2 mins after drug administration, was 13 +/- 2 and 23 +/- 6 mm Hg in the vasopressin group; 14 +/- 2 and 31 +/- 4 mm Hg in the epinephrine group; and 13 +/- 1 and 33 +/- 6 mm Hg in the epinephrine-vasopressin group, respectively (p = NS).	Epinephrine	211-222	vasopressin	Sus scrofa	157-168
11090979-4	2000	Electron microscopic immunocytochemistry revealed that PAC1-R was predominantly expressed in adrenaline-containing cells.	Epinephrine	93-103	ADCYAP receptor type I	Rattus norvegicus	55-61
11090111-2	2000	Activation of the recombinant human alpha(2C)-adrenoceptor (alpha(2C) AR) by (-)-adrenaline in CHO-K1 cells transiently co-expressing a chimeric G(alpha q/i1) protein induced a rapid, transient Ca(2+) response with a high-magnitude followed by a low-magnitude phase which continued throughout the recorded time period (15 min).	Epinephrine	77-91	adrenoceptor alpha 2C	Homo sapiens	36-58
11090111-2	2000	Activation of the recombinant human alpha(2C)-adrenoceptor (alpha(2C) AR) by (-)-adrenaline in CHO-K1 cells transiently co-expressing a chimeric G(alpha q/i1) protein induced a rapid, transient Ca(2+) response with a high-magnitude followed by a low-magnitude phase which continued throughout the recorded time period (15 min).	Epinephrine	77-91	adrenoceptor alpha 2C	Homo sapiens	60-72
11368324-7	2000	Both liver and brain solubilized MB-COMT were more efficient in methylating adrenaline than the respective native enzymes as revealed by higher Kcat values (P &lt; 0.05): 16.4+/-0.9 vs 10.9+/-0.8 min(-1) (brain) and 5.9+/-0.3 vs 3.3+/-0.2 min(-1) (liver).	Epinephrine	76-86	catechol-O-methyltransferase	Rattus norvegicus	36-40
11153614-11	2000	One of six vasopressin, six of six epinephrine, and four of six epinephrine-vasopressin-treated animals had return of spontaneous circulation (p &lt; .01, vasopressin vs. epinephrine).	Epinephrine	64-75	vasopressin	Sus scrofa	76-87
11153614-11	2000	One of six vasopressin, six of six epinephrine, and four of six epinephrine-vasopressin-treated animals had return of spontaneous circulation (p &lt; .01, vasopressin vs. epinephrine).	Epinephrine	64-75	vasopressin	Sus scrofa	76-87
11153614-10	2000	Total cerebral blood flow trended toward higher values after epinephrine-vasopressin (60 +/- 19 mL x min(-1) x 100 g(-1)) than after vasopressin (36 +/- 17 mL x min(-1) x 100 g(-1)) or epinephrine alone (31 +/- 7 mL x min(-1) x 100 g(-1); p = .07, respectively).	Epinephrine	61-72	vasopressin	Sus scrofa	73-84
11152280-3	2000	Cleavage of SNAP-25 by BoNT/A also had a larger inhibitory effect on noradrenaline release than on adrenaline release.	Epinephrine	72-82	synaptosome associated protein 25	Bos taurus	12-19
11093795-9	2000	Extracellular signal-regulated kinase (ERK) activity was stimulated by 0.1 microM epinephrine but not by 10 microM epinephrine.	Epinephrine	82-93	Eph receptor B1	Rattus norvegicus	0-37
11152280-2	2000	Cleavage of syntaxin and SNAP-25 by BoNT/C1 decreased in a dose-dependent way the release of both noradrenaline and adrenaline, but noradrenaline release was more sensitive to BoNT/C1.	Epinephrine	101-111	synaptosome associated protein 25	Bos taurus	25-32
11093795-9	2000	Extracellular signal-regulated kinase (ERK) activity was stimulated by 0.1 microM epinephrine but not by 10 microM epinephrine.	Epinephrine	82-93	Eph receptor B1	Rattus norvegicus	39-42
11093795-12	2000	In conclusion, low epinephrine concentrations attenuate ST-induced apoptosis of adult cardiac myocytes in vitro, an effect mediated by coupling between the cAMP pathway and ERK activation.	Epinephrine	19-30	Eph receptor B1	Rattus norvegicus	173-176
11086166-0	2000	Adrenaline potentiates PI 3-kinase in platelets stimulated with thrombin and SFRLLN: role of secreted ADP.	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	64-72
11086166-4	2000	It is concluded that adrenaline can replace secreted ADP to potentiate PtdIns(3,4)P(2) production in thrombin-stimulated but not in SFRLLN-stimulated platelets, thus demonstrating a qualitative difference between platelet stimulation by thrombin and the thrombin receptor activating peptide SFRLLN.	Epinephrine	21-31	coagulation factor II, thrombin	Homo sapiens	101-109
11086166-1	2000	Adrenaline significantly potentiated late thrombin- and SFRLLN-induced PtdIns(3,4)P(2) production.	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	42-50
11086166-4	2000	It is concluded that adrenaline can replace secreted ADP to potentiate PtdIns(3,4)P(2) production in thrombin-stimulated but not in SFRLLN-stimulated platelets, thus demonstrating a qualitative difference between platelet stimulation by thrombin and the thrombin receptor activating peptide SFRLLN.	Epinephrine	21-31	coagulation factor II, thrombin	Homo sapiens	237-245
11086166-4	2000	It is concluded that adrenaline can replace secreted ADP to potentiate PtdIns(3,4)P(2) production in thrombin-stimulated but not in SFRLLN-stimulated platelets, thus demonstrating a qualitative difference between platelet stimulation by thrombin and the thrombin receptor activating peptide SFRLLN.	Epinephrine	21-31	coagulation factor II, thrombin	Homo sapiens	237-245
11086166-2	2000	Furthermore, the potentiating effect of adrenaline on thrombin-induced PtdIns(3, 4)P(2) production was independent on secreted ADP, whereas, the effect of adrenaline on SFRLLN-induced PtdIns(3,4)P(2) production was completely dependent of secreted ADP.	Epinephrine	40-50	coagulation factor II, thrombin	Homo sapiens	54-62
11113273-0	2000	Adrenaline potentiates type 2B von Willebrand factor-induced activation of human platelets by enhancing both the formation and action of thromboxanes.	Epinephrine	0-10	von Willebrand factor	Homo sapiens	31-52
11071639-7	2000	Conversely, the Gi-dependent signaling pathway, initiated either by ADP or epinephrine, was required for FcgammaRIIA-mediated phospholipase C activation and calcium mobilization.	Epinephrine	75-86	Fc gamma receptor IIa	Homo sapiens	105-116
11078878-0	2000	Enhanced epinephrine-induced platelet aggregation in individuals carrying the G protein beta3 subunit 825T allele.	Epinephrine	9-20	G protein subunit beta 3	Homo sapiens	78-93
11113273-3	2000	The present report shows that adrenaline (1 microM) potentiates type 2B vWF-induced platelet aggregation, serotonin secretion, rise in cytosolic Ca(2+) concentration, and pleckstrin phosphorylation, as well as thromboxane B(2) production.	Epinephrine	30-40	von Willebrand factor	Homo sapiens	72-75
11113273-5	2000	Adrenaline also increases type 2B vWF-elicited tyrosine phosphorylation of proteins with apparent molecular masses of 60 and 80 kDa.	Epinephrine	0-10	von Willebrand factor	Homo sapiens	34-37
11113273-8	2000	These observations lead to the conclusion that the potentiating action of adrenaline on type 2B vWF-promoted platelet responses is due to an increase in both the formation and activating action of thromboxanes.	Epinephrine	74-84	von Willebrand factor	Homo sapiens	96-99
11085369-0	2000	Effect of epinephrine on GLUT2 protein content in mouse liver.	Epinephrine	10-21	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	25-30
11068015-7	2000	Adrenomedullin also caused desensitization of isoproterenol- and epinephrine-mediated cAMP accumulation.	Epinephrine	65-76	adrenomedullin	Rattus norvegicus	0-14
11089558-0	2000	Increased body fat mass and suppression of circulating leptin levels in response to hypersecretion of epinephrine in phenylethanolamine-N-methyltransferase (PNMT)-overexpressing mice.	Epinephrine	102-113	leptin	Mus musculus	55-61
11696892-4	2000	The inhibition constants for binding of the nascent C4b to its target were determined for immunoglobulins G1, G2, G3, G4, M, and A1, as well as for ferritin, yeast mannan, capsid polysaccharides of the Neisseria meningitidis A, B, and C serotypes, diphtheria anatoxin, epinephrine, and salicylic acid.	Epinephrine	269-280	complement C4B (Chido blood group)	Homo sapiens	52-55
11089558-0	2000	Increased body fat mass and suppression of circulating leptin levels in response to hypersecretion of epinephrine in phenylethanolamine-N-methyltransferase (PNMT)-overexpressing mice.	Epinephrine	102-113	phenylethanolamine-N-methyltransferase	Mus musculus	117-155
11089558-0	2000	Increased body fat mass and suppression of circulating leptin levels in response to hypersecretion of epinephrine in phenylethanolamine-N-methyltransferase (PNMT)-overexpressing mice.	Epinephrine	102-113	phenylethanolamine-N-methyltransferase	Mus musculus	157-161
11089558-3	2000	A 100-fold overexpression of PNMT and subsequent elevation of epinephrine levels resulted in a marked suppression of circulating leptin levels in the transgenic animals (1.14 +/- 0.05 vs. 2.17 +/- 0.35 ng/ml; P &lt; 0.01), which correlated negatively with plasma epinephrine (r = -0.82; P &lt; 0.05), thus providing evidence for an inhibitory action of epinephrine on leptin production in vivo.	Epinephrine	62-73	leptin	Mus musculus	129-135
11089558-3	2000	A 100-fold overexpression of PNMT and subsequent elevation of epinephrine levels resulted in a marked suppression of circulating leptin levels in the transgenic animals (1.14 +/- 0.05 vs. 2.17 +/- 0.35 ng/ml; P &lt; 0.01), which correlated negatively with plasma epinephrine (r = -0.82; P &lt; 0.05), thus providing evidence for an inhibitory action of epinephrine on leptin production in vivo.	Epinephrine	263-274	phenylethanolamine-N-methyltransferase	Mus musculus	29-33
11089558-3	2000	A 100-fold overexpression of PNMT and subsequent elevation of epinephrine levels resulted in a marked suppression of circulating leptin levels in the transgenic animals (1.14 +/- 0.05 vs. 2.17 +/- 0.35 ng/ml; P &lt; 0.01), which correlated negatively with plasma epinephrine (r = -0.82; P &lt; 0.05), thus providing evidence for an inhibitory action of epinephrine on leptin production in vivo.	Epinephrine	263-274	phenylethanolamine-N-methyltransferase	Mus musculus	29-33
11089558-7	2000	In summary, sustained primary overproduction of epinephrine resulted in suppression of plasma leptin levels and increased lipid storage in the PNMT transgenic mice.	Epinephrine	48-59	leptin	Mus musculus	94-100
11089558-7	2000	In summary, sustained primary overproduction of epinephrine resulted in suppression of plasma leptin levels and increased lipid storage in the PNMT transgenic mice.	Epinephrine	48-59	phenylethanolamine-N-methyltransferase	Mus musculus	143-147
11023712-2	2000	We found that platelet aggregation mediated by subthreshold concentrations of histamine (1-4 microm) plus adrenaline (0.5-2 microm) is inhibited by both an alpha(2)-adrenoceptor blocker (yohimbine) and a histamine (H1) receptor antagonist (diphenhydramine).	Epinephrine	106-116	histamine receptor H1	Homo sapiens	204-227
11023712-4	2000	However, platelet aggregation by adrenaline plus histamine was inhibited by very low concentrations of the phospholipase C (PLC) inhibitor, U73122 (IC(50)= 1.2 microm), the MEK inhibitor, PD98059 (IC(50)= 1.1 microm) and the cyclo-oxygenase (COX) inhibitor, indomethacin (IC(50)= 7 microm).	Epinephrine	33-43	mitogen-activated protein kinase kinase 7	Homo sapiens	173-176
10998345-3	2000	Adrenaline (epinephrine)-stimulated glucose release (42.6 +/- 4.5 micromol/g of liver within 30 min) was inhibited (P &lt; 0.05) by approximately 32 and approximately 52% during IGF-I and insulin exposure, which was accompanied by reduced cAMP release (-71 and -80%, P &lt; 0.05).	Epinephrine	0-10	insulin-like growth factor 1	Rattus norvegicus	178-183
11064152-11	2000	StAR expression was elevated by 8.3-, 2.5- and 4.7-fold upon stimulation with forskolin, isoproterenol and adrenalin, respectively.	Epinephrine	107-116	steroidogenic acute regulatory protein	Homo sapiens	0-4
11034626-6	2000	Adrenaline infusion increased activities of phosphorylase and HSL as well as blood lactate concentrations compared with those in -Adr, but did not enhance glycogen breakdown (+Adr, glycogen following exercise: 274+/-55 mmol (kg dry wt)(-1)) in contracting muscle.	Epinephrine	0-10	lipase E, hormone sensitive type	Homo sapiens	62-65
11034626-9	2000	Finally, a novel finding is that the activity of HSL in human muscle is increased in exercising man and this is due, at least partly, to stimulation by adrenaline.	Epinephrine	152-162	lipase E, hormone sensitive type	Homo sapiens	49-52
10998345-3	2000	Adrenaline (epinephrine)-stimulated glucose release (42.6 +/- 4.5 micromol/g of liver within 30 min) was inhibited (P &lt; 0.05) by approximately 32 and approximately 52% during IGF-I and insulin exposure, which was accompanied by reduced cAMP release (-71 and -80%, P &lt; 0.05).	Epinephrine	12-23	insulin-like growth factor 1	Rattus norvegicus	178-183
10998345-6	2000	In conclusion, IGF-I causes (i) insulin-like inhibition of hepatic glycogenolysis, even at low, nanomolar concentrations, which is associated with decreased cAMP release, reduced in the absence of Ca(2+), but not mediated by phosphoinositide 3-kinase, (ii) reduction of adrenaline-induced glycogenolysis and (iii) net potassium uptake under basal conditions.	Epinephrine	270-280	insulin-like growth factor 1	Rattus norvegicus	15-20
11013311-1	2000	Modulation of cytosolic phospholipase A(2) (cPLA(2)) activity by sphingomyelin (SPH), ceramide (Cer), and cholesterol (Chol) was investigated in CHO-2B cells activated by the calcium ionophore A23187 and epinephrine.	Epinephrine	204-215	phospholipase A2 group IVA	Homo sapiens	14-51
11033330-9	2000	Furthermore, neuropeptides such as CRF and vasopressin modulate the release of stress hormones such as epinephrine.	Epinephrine	103-114	arginine vasopressin	Rattus norvegicus	43-54
11072780-0	2000	Changes in plasma concentrations of interleukin-6 and interleukin-1 receptor antagonists in response to adrenaline infusion in humans.	Epinephrine	104-114	interleukin 6	Homo sapiens	36-49
11027510-6	2000	Substitution of the second intracellular loop (2i) of the betaAR led to a significant decrease in coupling to adenylate cyclase while leading to a 139.5 +/- 9.4% control increase in epinephrine mediated PKC activation.	Epinephrine	182-193	adrenoceptor beta 2	Homo sapiens	58-64
10967299-9	2000	The results show that many adrenergic neurons are direct targets for estradiol and that most PNMT neurons in the brainstem are activated during the initiation of the steroid-induced LH surge which suggests that epinephrine is one of the triggers that stimulates GnRH release during the surge.	Epinephrine	211-222	phenylethanolamine-N-methyltransferase	Rattus norvegicus	93-97
11072780-5	2000	The plasma concentration of IL-6 had increased by two- to threefold after 45 min of adrenaline infusion (P&lt;0.01) and was still elevated 1 h after the infusion had ended (P&lt;0.001 and P&lt;0.05 in controls and HIV infected patients, respectively).	Epinephrine	84-94	interleukin 6	Homo sapiens	28-32
11072780-6	2000	The plasma concentration of IL-1ra had increased two- to threefold 1 h after ceasing the adrenaline infusion (P&lt;0.05 and P&lt;0.01 in controls and HIV infected patients, respectively).	Epinephrine	89-99	interleukin 1 receptor antagonist	Homo sapiens	28-34
11072780-9	2000	The present study supports the existence of a relationship between the plasma concentration of adrenaline and IL-6.	Epinephrine	95-105	interleukin 6	Homo sapiens	110-114
11072780-10	2000	It is possible that an increased adrenaline concentration in plasma induces a continued de novo synthesis of IL-6, thereby increasing plasma IL-6 in a time-dose dependent manner.	Epinephrine	33-43	interleukin 6	Homo sapiens	109-113
11072780-10	2000	It is possible that an increased adrenaline concentration in plasma induces a continued de novo synthesis of IL-6, thereby increasing plasma IL-6 in a time-dose dependent manner.	Epinephrine	33-43	interleukin 6	Homo sapiens	141-145
10777495-11	2000	Exposure of epinephrine translocated AQPap protein from perinuclear cytoplasm to the plasma membrane in 3T3-L1 adipocytes.	Epinephrine	12-23	aquaporin 7	Mus musculus	37-42
11108138-3	2000	The addition of norepinephrine (NE), isoproterenol (a beta1/beta2-adrenergic receptor (AR) agonist) and iodoclonidine (an alpha2-AR agonist) stimulated the expression of the ANG-GH fusion gene in a dose-dependent manner, whereas the addition of epinephrine and phenylephrine (alpha1-AR agonist) had no effect.	Epinephrine	19-30	angiotensinogen	Homo sapiens	174-177
10801795-6	2000	The polymorphic receptor displayed markedly depressed epinephrine-promoted coupling to G(i), inhibiting adenylyl cyclase by 10 +/- 4.3% compared with 73 +/- 2.4% for wild-type alpha(2C)AR.	Epinephrine	54-65	adrenoceptor alpha 2C	Homo sapiens	176-187
10940480-8	2000	Consistently, the major secretion of chromaffin cells, epinephrine dose-dependently stimulated StAR expression with no effect on PBR mRNA.	Epinephrine	55-66	steroidogenic acute regulatory protein	Bos taurus	95-99
10974664-3	2000	Analysis of dose-response curves indicated that VIP and PACAP stimulated the secretion of adrenaline with a similar degree of potency (ED(50) for VIP=1.90x10(-11) mol/kg; ED(50) for PACAP=1.03x10(-11) mol/kg).	Epinephrine	90-100	vasoactive intestinal peptide	Gallus gallus	48-51
10974664-3	2000	Analysis of dose-response curves indicated that VIP and PACAP stimulated the secretion of adrenaline with a similar degree of potency (ED(50) for VIP=1.90x10(-11) mol/kg; ED(50) for PACAP=1.03x10(-11) mol/kg).	Epinephrine	90-100	vasoactive intestinal peptide	Gallus gallus	146-149
10906719-2	2000	The localisation of calbindin immunoreactivity in the medulla oblongata and its colocalisation with adrenaline-synthesising neurons [phenylethanolamine-N-methyltransferase-immunoreactive (PNMT-IR)] was examined (Granata and Chang [1994] Brain Res.	Epinephrine	100-110	calbindin 1	Rattus norvegicus	20-29
10929058-0	2000	Adrenaline inhibits macrophage nitric oxide production through beta1 and beta2 adrenergic receptors.	Epinephrine	0-10	hemoglobin, beta adult major chain	Mus musculus	63-68
10929058-0	2000	Adrenaline inhibits macrophage nitric oxide production through beta1 and beta2 adrenergic receptors.	Epinephrine	0-10	hemoglobin, beta adult minor chain	Mus musculus	73-78
10929058-4	2000	The suppressive effect of adrenaline on NO production was mediated via beta1 and beta2 adrenergic receptors since isoprenaline (a non-selective beta1 and beta2 agonist), dobutamine and salbutamol (selective beta1 and beta2 agonists, respectively) had similar effects on the NO response.	Epinephrine	26-36	hemoglobin, beta adult major chain	Mus musculus	71-76
10929058-4	2000	The suppressive effect of adrenaline on NO production was mediated via beta1 and beta2 adrenergic receptors since isoprenaline (a non-selective beta1 and beta2 agonist), dobutamine and salbutamol (selective beta1 and beta2 agonists, respectively) had similar effects on the NO response.	Epinephrine	26-36	hemoglobin, beta adult minor chain	Mus musculus	81-86
10929058-4	2000	The suppressive effect of adrenaline on NO production was mediated via beta1 and beta2 adrenergic receptors since isoprenaline (a non-selective beta1 and beta2 agonist), dobutamine and salbutamol (selective beta1 and beta2 agonists, respectively) had similar effects on the NO response.	Epinephrine	26-36	hemoglobin, beta adult major chain	Mus musculus	144-149
10929058-4	2000	The suppressive effect of adrenaline on NO production was mediated via beta1 and beta2 adrenergic receptors since isoprenaline (a non-selective beta1 and beta2 agonist), dobutamine and salbutamol (selective beta1 and beta2 agonists, respectively) had similar effects on the NO response.	Epinephrine	26-36	hemoglobin, beta adult minor chain	Mus musculus	154-159
10929058-4	2000	The suppressive effect of adrenaline on NO production was mediated via beta1 and beta2 adrenergic receptors since isoprenaline (a non-selective beta1 and beta2 agonist), dobutamine and salbutamol (selective beta1 and beta2 agonists, respectively) had similar effects on the NO response.	Epinephrine	26-36	hemoglobin, beta adult major chain	Mus musculus	144-149
10929058-4	2000	The suppressive effect of adrenaline on NO production was mediated via beta1 and beta2 adrenergic receptors since isoprenaline (a non-selective beta1 and beta2 agonist), dobutamine and salbutamol (selective beta1 and beta2 agonists, respectively) had similar effects on the NO response.	Epinephrine	26-36	hemoglobin, beta adult minor chain	Mus musculus	154-159
10929058-5	2000	In addition, the inhibitory effect of adrenaline on NO was abrogated by both propranolol (a non-specific beta blocker) and atenolol (a specific beta1 inhibitor).	Epinephrine	38-48	hemoglobin, beta adult major chain	Mus musculus	144-149
10856891-7	2000	Using this assay we investigated the short-term effects of insulin, adrenaline and glucagon (all modulators of blood glucose) on plasma leptin levels.	Epinephrine	68-78	leptin	Homo sapiens	136-142
10898900-2	2000	The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility.	Epinephrine	127-137	catechol-O-methyltransferase	Homo sapiens	11-39
10845892-8	2000	Treatment of transduced megakaryocytes with a combination of agonists including epinephrine and the thrombin receptor-activating peptide induced the alphaIIbbeta(3) complex to form an activated conformation capable of binding fibrinogen as measured by PAC-1 antibody binding.	Epinephrine	80-91	fibrinogen beta chain	Homo sapiens	226-236
10845892-8	2000	Treatment of transduced megakaryocytes with a combination of agonists including epinephrine and the thrombin receptor-activating peptide induced the alphaIIbbeta(3) complex to form an activated conformation capable of binding fibrinogen as measured by PAC-1 antibody binding.	Epinephrine	80-91	ADCYAP receptor type I	Homo sapiens	252-257
10898900-2	2000	The enzyme catechol-O-methyltransferase (COMT) plays a key role in the degradation of catecholamines such as dopamine, L-DOPA, adrenaline, and noradrenaline and therefore could be considered as a candidate locus for ADHD susceptibility.	Epinephrine	127-137	catechol-O-methyltransferase	Homo sapiens	41-45
10751543-11	2000	In addition, epinephrine, a typical G(i) agonist against platelets, could potentiate the plasmin-induced platelet aggregation, suggesting that the signal via the G(i) protein is involved in potentiating the plasmin-induced platelet aggregation, ADP is secreted from platelet granules, and concomitantly works in conjunction with plasmin in a P2T(AC) receptor-mediated manner.	Epinephrine	13-24	plasminogen	Homo sapiens	89-96
10751543-11	2000	In addition, epinephrine, a typical G(i) agonist against platelets, could potentiate the plasmin-induced platelet aggregation, suggesting that the signal via the G(i) protein is involved in potentiating the plasmin-induced platelet aggregation, ADP is secreted from platelet granules, and concomitantly works in conjunction with plasmin in a P2T(AC) receptor-mediated manner.	Epinephrine	13-24	plasminogen	Homo sapiens	207-214
10751543-11	2000	In addition, epinephrine, a typical G(i) agonist against platelets, could potentiate the plasmin-induced platelet aggregation, suggesting that the signal via the G(i) protein is involved in potentiating the plasmin-induced platelet aggregation, ADP is secreted from platelet granules, and concomitantly works in conjunction with plasmin in a P2T(AC) receptor-mediated manner.	Epinephrine	13-24	plasminogen	Homo sapiens	207-214
10751543-11	2000	In addition, epinephrine, a typical G(i) agonist against platelets, could potentiate the plasmin-induced platelet aggregation, suggesting that the signal via the G(i) protein is involved in potentiating the plasmin-induced platelet aggregation, ADP is secreted from platelet granules, and concomitantly works in conjunction with plasmin in a P2T(AC) receptor-mediated manner.	Epinephrine	13-24	purinergic receptor P2Y12	Homo sapiens	342-349
10954071-8	2000	Adrenaline concentrations correlated inversely with insulin concentrations.	Epinephrine	0-10	insulin	Homo sapiens	52-59
10952808-3	2000	In one study, a combination of the injection of adrenaline and a high dose of thrombin was superior to using adrenaline alone.	Epinephrine	109-119	coagulation factor II, thrombin	Homo sapiens	78-86
10954071-12	2000	The authors conclude that, in patients with diabetes, resting adrenaline concentrations are related to insulin concentrations.	Epinephrine	62-72	insulin	Homo sapiens	103-110
10942111-1	2000	Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space.	Epinephrine	209-219	solute carrier family 22 member 1	Homo sapiens	36-40
10834930-3	2000	We now demonstrate that epinephrine as well as norepinephrine can induce IL-6 in an endothelial cell line (HMEC-1).	Epinephrine	24-35	interleukin 6	Homo sapiens	73-77
10942111-1	2000	Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space.	Epinephrine	209-219	solute carrier family 22 member 2	Homo sapiens	42-46
10942111-1	2000	Non-neuronal monoamine transporters OCT1, OCT2, and EMT, which are all members of the amphiphilic solute facilitator family, control signal transmission by removing released transmitters, such as dopamine, noradrenaline, adrenaline, 5-hydroxytryptamine, and histamine, from the extracellular space.	Epinephrine	209-219	IL2 inducible T cell kinase	Homo sapiens	52-55
11086881-0	2000	The beta3-adrenoceptor-mediated relaxation induced by epinephrine in guinea pig taenia caecum.	Epinephrine	54-65	beta-3 adrenergic receptor	Cavia porcellus	4-22
10790353-2	2000	The combination of endothelin-1 (ET-1) plus epinephrine improved CPP during CPR compared with epinephrine alone in a canine cardiac arrest model.	Epinephrine	94-105	endothelin 1	Canis lupus familiaris	19-31
10790353-2	2000	The combination of endothelin-1 (ET-1) plus epinephrine improved CPP during CPR compared with epinephrine alone in a canine cardiac arrest model.	Epinephrine	94-105	endothelin 1	Canis lupus familiaris	33-37
11324438-3	2000	Superoxide dismutases (SOD) and catalase (CAT) activities were measured based on their abilities to inhibit the oxidation of epinephrine by the xanthine-xanthine oxidase system or to decompose H2O2 respectively.	Epinephrine	125-136	catalase	Rattus norvegicus	32-40
10855527-4	2000	Epinephrine increases hepatic glucose production and inhibits insulin secretion and the glucose uptake by tissues that is induced by insulin.	Epinephrine	0-11	insulin	Homo sapiens	62-69
11324438-3	2000	Superoxide dismutases (SOD) and catalase (CAT) activities were measured based on their abilities to inhibit the oxidation of epinephrine by the xanthine-xanthine oxidase system or to decompose H2O2 respectively.	Epinephrine	125-136	catalase	Rattus norvegicus	42-45
10780953-3	2000	If epinephrine (Epi) infusion during moderate exercise were able to markedly stimulate R(a), this would support an important role for the catecholamines" response in IE.	Epinephrine	3-14	tissue factor pathway inhibitor	Homo sapiens	16-19
10801302-4	2000	Plasma catecholamine concentrations significantly increased at 60 min after intracerebroventricular injection of leptin (control vs. 60 min; epinephrine: 33 +/- 12 vs. 97 +/- 27 pg/ml, P &lt; 0.05; norepinephrine: 298 +/- 39 vs. 503 +/- 86 pg/ml, P &lt; 0.05).	Epinephrine	141-152	leptin	Oryctolagus cuniculus	113-119
10780996-0	2000	Central injection of nitric oxide synthase inhibitors increases peripheral interleukin-6 and serum amyloid A: involvement of adrenaline from adrenal medulla.	Epinephrine	125-135	nitric oxide synthase 1, neuronal	Mus musculus	21-42
10780996-33	2000	These results suggest that NOS activity in the brain tonically down-regulates peripheral IL-6 by inhibiting adrenaline release from the adrenal medulla.	Epinephrine	108-118	interleukin 6	Mus musculus	89-93
10698161-0	2000	Epidermal growth factor secreted from submandibular salivary glands interferes with the lipolytic effect of adrenaline in mice.	Epinephrine	108-118	epidermal growth factor	Mus musculus	0-23
10877009-10	2000	Of the 14 substances analyzed, adrenaline, serotonin, and 5-hydroxytriptofol were full inhibitors of CYP3A enzyme activity (Ki values of 42.3, 26.4, and 43 microM, respectively).	Epinephrine	31-41	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	101-106
10710496-1	2000	It has been suggested that insulin-induced suppression of endogenous glucose production (EGP) may be counteracted independently of increased epinephrine (Epi) or glucagon during moderate hypoglycemia.	Epinephrine	141-152	insulin	Homo sapiens	27-34
10710496-21	2000	We conclude that glucagon- or epinephrine-independent activation of EGP may accompany other counterregulatory mechanisms during mild hypoglycemia in humans and is impaired or absent in DM1.	Epinephrine	30-41	immunoglobulin heavy diversity 1-7	Homo sapiens	185-188
10698191-5	2000	CRH KO mice had significantly lower plasma epinephrine and higher norepinephrine than WT mice at baseline, and delayed epinephrine secretion during restraint.	Epinephrine	43-54	corticotropin releasing hormone	Mus musculus	0-3
10698191-5	2000	CRH KO mice had significantly lower plasma epinephrine and higher norepinephrine than WT mice at baseline, and delayed epinephrine secretion during restraint.	Epinephrine	69-80	corticotropin releasing hormone	Mus musculus	0-3
10698191-9	2000	We conclude that glucocorticoid insufficiency in CRH KO mice leads to decreased basal and restraint-induced plasma epinephrine and adrenal PNMT gene expression and enzyme activity.	Epinephrine	115-126	corticotropin releasing hormone	Mus musculus	49-52
10766790-5	2000	An additive loss in affinity (150-fold) for epinephrine was observed at an alpha(1a) containing both mutations.	Epinephrine	44-55	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	75-83
10809289-8	2000	Significantly lower mean +/- SEM epinephrine concentrations in the vasopressin pigs compared with the placebo group were measured 1.5 mins and 5 mins after drug administration, (24167+/-7919 vs. 80223+/-19391 pg/mL [p &lt; .01] and 8346+/-1454 vs. 71345+/-10758 pg/mL [p &lt; .01]).	Epinephrine	33-44	vasopressin	Sus scrofa	67-78
10737636-8	2000	PNMT is the enzyme that converts noradrenaline to adrenaline and is not expressed in noradrenaline-secreting cells.	Epinephrine	36-46	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-4
10737636-13	2000	As it has been reported that adrenomedullin is synthesised predominantly by adrenaline-secreting cells, it appears likely that adrenomedullin is a paracrine regulator in the adrenal medulla.	Epinephrine	76-86	adrenomedullin	Rattus norvegicus	29-43
10737636-13	2000	As it has been reported that adrenomedullin is synthesised predominantly by adrenaline-secreting cells, it appears likely that adrenomedullin is a paracrine regulator in the adrenal medulla.	Epinephrine	76-86	adrenomedullin	Rattus norvegicus	127-141
10700658-3	2000	This effect involves sympathetic nervous system (SNS) activation, since CRH-treatment resulted in a marked increase in plasma norepinephrine (NE) and epinephrine (E), and sympathetic blockade by subcutaneously injected atenolol (1 mg/kg), a beta1-selective adrenergic antagonist, completely prevented the CRH-induced tachycardia.	Epinephrine	129-140	corticotropin releasing hormone	Rattus norvegicus	72-75
10863002-3	2000	Epinephrine treatment resulted in a three-fold increase in extractable mu-calpain activity (P &lt; 0.05), a three-fold increase in extractable m-calpain activity (P &lt; 0.05), a 36% increase in calpastatin activity (P &lt; 0.001), and a 16% decrease (P &lt; 0.05) in the total protein content in the C2C12 cell homogenate.	Epinephrine	0-11	calpain 1	Mus musculus	71-81
10834092-1	2000	It has been found that the sigma 1- and sigma 3-receptor antagonists, DuP 734 intraperitoneally and XJ 448 intravenously, had antiarrhythmic effects against epinephrine-induced arrhythmias in rats.	Epinephrine	157-168	sigma non-opioid intracellular receptor 1	Rattus norvegicus	27-56
10698161-5	2000	After adrenaline administration plasma EGF increased by 20-fold in sham-operated but did not increase in sialoadenectomized mice.	Epinephrine	6-16	epidermal growth factor	Mus musculus	39-42
10698161-7	2000	The effect of adrenaline on plasma concentration of both glycerol and nonesterified fatty acids was higher as lower was plasma EGF concentration.	Epinephrine	14-24	epidermal growth factor	Mus musculus	127-130
10698161-13	2000	These results suggest that EGF in the physiological range decreases the lipolytic effect of adrenaline but does not compromise further metabolic events like the enhancement of ketogenesis.	Epinephrine	92-102	epidermal growth factor	Mus musculus	27-30
10823386-3	2000	MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production.	Epinephrine	30-41	tumor necrosis factor	Homo sapiens	107-134
10786926-5	2000	The responses of the mutant receptor to epinephrine, norepinephrine and L-755,507, a highly specific agonist for human beta3-adrenergic receptor, were also reduced, but the reduction of Kact for L-755,507 was more evident than other agonists tested.	Epinephrine	40-51	adrenoceptor beta 3	Homo sapiens	119-144
10823386-3	2000	MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production.	Epinephrine	30-41	tumor necrosis factor	Homo sapiens	136-139
10823386-3	2000	MAIN RESULTS: Catecholamines (epinephrine, norepinephrine, isoproterenol, and dopamine) in general inhibit tumor necrosis factor-alpha (TNF) production and may enhance interleukin-6 (IL-6) and IL-10 production.	Epinephrine	30-41	interleukin 6	Homo sapiens	168-181
10887949-3	2000	In an in vitro human platelet aggregation assay, the IC50 values (microM) of NSP-513 for platelet aggregation induced by collagen, U-46619, arachidonic acid, adenosine diphosphate (ADP), epinephrine and thrombin were 0.31, 0.25, 0.082, 0.66, 0.23 and 0.73, respectively.	Epinephrine	187-198	sperm antigen with calponin homology and coiled-coil domains 1	Homo sapiens	77-80
10728402-0	2000	Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway.	Epinephrine	20-31	Fas ligand	Homo sapiens	112-122
10731002-10	2000	The epinephrine concentration ([Epi]) obtained at the T(La) was not significantly different for arm (0.144 ng x mL(-1)) and leg (0.152 ng x mL(-1)) exercise.	Epinephrine	4-15	tissue factor pathway inhibitor	Homo sapiens	32-35
10728402-0	2000	Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway.	Epinephrine	20-31	caspase 3	Homo sapiens	127-136
10728402-10	2000	CONCLUSION: Epinephrine induces apoptosis in HCAECs, and this effect is associated with activation of Fas-FasL and caspase-3 signal transduction pathway.	Epinephrine	12-23	Fas ligand	Homo sapiens	106-110
10728402-10	2000	CONCLUSION: Epinephrine induces apoptosis in HCAECs, and this effect is associated with activation of Fas-FasL and caspase-3 signal transduction pathway.	Epinephrine	12-23	caspase 3	Homo sapiens	115-124
10648825-0	2000	Phosphorylation of the skeletal muscle glycogen-targetting subunit of protein phosphatase 1 in response to adrenaline in vivo.	Epinephrine	107-117	inorganic pyrophosphatase 1	Homo sapiens	70-91
10640303-4	2000	The basal [(35)S]GTPgammaS binding response displayed a constitutive alpha(2A)-AR activity that amounted to 21% of the maximal receptor activation as obtained with 10 microM (-)-adrenaline.	Epinephrine	174-188	adrenoceptor alpha 2A	Homo sapiens	69-81
10690944-10	2000	This finding may be attributable to a relative insulin resistance induced by epinephrine, resulting in a decreased rate of glucose clearance by cells.	Epinephrine	77-88	insulin	Homo sapiens	47-54
11193830-9	2000	We, therefore, conclude that under in vivo conditions, epinephrine released by PACAP from the adrenals prevents the marked insulinotropic action of the peptide from augmenting glucose disposal.	Epinephrine	55-66	adenylate cyclase activating polypeptide 1	Mus musculus	79-84
11268424-3	2000	Recent evidence indicates that glucocorticoids, norepinephrine, epinephrine, histamine, and adenosine inhibit the production of human IL-12 and TNF-alpha, whereas they do not affect or even stimulate the production of IL-10.	Epinephrine	51-62	tumor necrosis factor	Homo sapiens	144-153
10855737-8	2000	The increase in insulin sensitivity in men was negatively correlated to maximal AIR (r = -0.36, p &lt; 0.05), and was independently correlated to relative changes in FBF (beta = 0.46) and in circulating epinephrine (beta = 0.33; adj.	Epinephrine	203-214	insulin	Homo sapiens	16-23
10970992-4	2000	TNF concentrations were significantly correlated with the 24-hour excretion of epinephrine and norepinephrine (r = 0.64 and 0.69; each p &lt; 0.01).	Epinephrine	79-90	tumor necrosis factor	Homo sapiens	0-3
10651786-8	2000	After baseline measurements, adrenaline was infused at a rate of 0.3 nmol kg-1 min-1.	Epinephrine	29-39	CD59 molecule (CD59 blood group)	Homo sapiens	79-84
10651786-10	2000	During infusion of adrenaline, blood flow and lactate output increased significantly more in the non-dominant arm (8.12 +/- 1.24 versus 6.45 +/- 1.19 ml 100 g-1 min-1) and (2.99 +/- 0.60 versus 1.83 +/- 0.43 micromol 100 g-1 min-1).	Epinephrine	19-29	CD59 molecule (CD59 blood group)	Homo sapiens	161-166
10651786-10	2000	During infusion of adrenaline, blood flow and lactate output increased significantly more in the non-dominant arm (8.12 +/- 1.24 versus 6.45 +/- 1.19 ml 100 g-1 min-1) and (2.99 +/- 0.60 versus 1.83 +/- 0.43 micromol 100 g-1 min-1).	Epinephrine	19-29	CD59 molecule (CD59 blood group)	Homo sapiens	225-230
10796682-8	2000	MAIN RESULTS: One trial in Sri Lanka (n = 105) giving adrenaline with polyspecific antivenom showed fewer adverse reactions in the adrenaline group, and this effect was preserved when stratified for severity.	Epinephrine	131-141	sorcin	Homo sapiens	27-30
10796682-8	2000	MAIN RESULTS: One trial in Sri Lanka (n = 105) giving adrenaline with polyspecific antivenom showed fewer adverse reactions in the adrenaline group, and this effect was preserved when stratified for severity.	Epinephrine	54-64	sorcin	Homo sapiens	27-30
10651786-11	2000	Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	136-141
10651786-11	2000	Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	193-198
10651786-11	2000	Adrenaline induced a significant increase in oxygen uptake in the non-dominant forearm (baseline period: 4.98 +/- 0.72 micromol 100 g-1 min-1; adrenaline period: 6.63 +/- 0.62 micromol 100 g-1 min-1) while there was no increase in the dominant forearm (baseline period: 5.69 +/- 1.03 micromol 100 g-1 min-1; adrenaline period: 4.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	193-198
10617142-2	2000	Activation of the wild-type alpha2B AR-Galpha15 fusion protein in CHO-K1 cells by (-)-adrenaline induced a time- and concentration-dependent (pEC50 = 7.37+/-0.13) increase in the intracellular Ca2+ concentration, which could be antagonized by RX 811059 (pK(B) = 7.55+/-0.15).	Epinephrine	82-96	adrenergic receptor, alpha 2b	Mus musculus	28-38
11149624-10	2000	Epinephrine levels were also higher during insulin as compared to placebo infusion (249.8+/-17.4 vs. 212.8+/-21.1 pmol/l, p&lt;0.001).	Epinephrine	0-11	insulin	Homo sapiens	43-50
10649440-7	2000	After its autophosphorylation by ecto-kinase activity, a 98-kDa membrane protein in P19 cells was found to be sensitive to ecto-ALP, and protein dephosphorylation increased after incubation of cells with RA for 24 h and 48 h. Orthovanadate, an inhibitor of all phosphatase activities, blocked the levamisole-sensitive dephosphorylation of the membrane phosphoproteins, while (R)-(-)-epinephrine reversed the effect by complexation of the inhibitor.	Epinephrine	375-394	tripartite motif containing 33	Homo sapiens	123-127
10649440-7	2000	After its autophosphorylation by ecto-kinase activity, a 98-kDa membrane protein in P19 cells was found to be sensitive to ecto-ALP, and protein dephosphorylation increased after incubation of cells with RA for 24 h and 48 h. Orthovanadate, an inhibitor of all phosphatase activities, blocked the levamisole-sensitive dephosphorylation of the membrane phosphoproteins, while (R)-(-)-epinephrine reversed the effect by complexation of the inhibitor.	Epinephrine	375-394	alkaline phosphatase, placental	Homo sapiens	128-131
10617142-2	2000	Activation of the wild-type alpha2B AR-Galpha15 fusion protein in CHO-K1 cells by (-)-adrenaline induced a time- and concentration-dependent (pEC50 = 7.37+/-0.13) increase in the intracellular Ca2+ concentration, which could be antagonized by RX 811059 (pK(B) = 7.55+/-0.15).	Epinephrine	82-96	guanine nucleotide binding protein, alpha 15	Mus musculus	39-47
21312134-4	2000	Most beta-agonists in clinical use are structural derivatives of the endogenous beta(2)AR agonist, adrenaline, including substituted catecholamines, such as isoprenaline and isoetharine; resourcinols, such as metaproterenol, fenoterol, and terbutaline; and saligenins, such as salbutamol and salmeterol.	Epinephrine	99-109	adrenoceptor beta 2	Homo sapiens	80-89
10604981-5	2000	If the charged state of D125 is important for agonist binding, then changing the type of amino acid at position 331 should decrease the acid strength of D125, leading to epinephrine affinity changes for the alpha(1b)-AR.	Epinephrine	170-181	adrenoceptor alpha 1B	Homo sapiens	217-219
10870684-6	2000	After epinephrine treatment, in both cell lines, the level of HSP72 did not elevate.	Epinephrine	6-17	heat shock protein family A (Hsp70) member 1A	Homo sapiens	62-67
10965235-3	2000	For this purpose, acute endotoxemia was induced in adult male rats pretreated intraperitoneally with either different inhibitors of phenylethanolamine-N-methyltransferase (PNMT) [which are active either peripherally (SKF 29661) or both peripherally and centrally (SKF 64139), thus lowering epinephrine (EPI) synthesis] or vehicle only (CTRL).	Epinephrine	290-301	phenylethanolamine-N-methyltransferase	Rattus norvegicus	172-176
10629439-1	2000	In intact PC12/alpha(2A/D) cells, the ability of either epinephrine or the alpha(2)-receptor-selective agonist UK14304 to stimulate PLD was completely dependent on concomitant PKC activation.	Epinephrine	56-67	protein kinase C, gamma	Rattus norvegicus	176-179
11124582-8	2000	Administration of adrenaline (0.1-1 mg/kg) or of a beta-adrenergic agonist (metaproterenol, 0.8 mg/kg), in physiologically relevant doses, suppressed NKA in a dose-dependent manner, and increased LTR to levels characteristic of swim stress.	Epinephrine	18-28	Natural killer alloreactivity QTL 1	Rattus norvegicus	150-153
10604389-3	2000	MATERIALS AND METHODS: As a first step toward understanding the molecular mechanisms by which adrenaline synthesis is controlled in these tumors, we measured the level of mRNA coding for the adrenaline-synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) and the content of adrenaline in the pheochromocytomas (n = 9), including 3 cases of the adrenaline-secreting type (one of the patients had bilateral pheochromocytomas), and in normal adrenal medullas (n = 7).	Epinephrine	191-201	phenylethanolamine N-methyltransferase	Homo sapiens	263-267
10604389-3	2000	MATERIALS AND METHODS: As a first step toward understanding the molecular mechanisms by which adrenaline synthesis is controlled in these tumors, we measured the level of mRNA coding for the adrenaline-synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) and the content of adrenaline in the pheochromocytomas (n = 9), including 3 cases of the adrenaline-secreting type (one of the patients had bilateral pheochromocytomas), and in normal adrenal medullas (n = 7).	Epinephrine	191-201	phenylethanolamine N-methyltransferase	Homo sapiens	263-267
10604389-3	2000	MATERIALS AND METHODS: As a first step toward understanding the molecular mechanisms by which adrenaline synthesis is controlled in these tumors, we measured the level of mRNA coding for the adrenaline-synthesizing enzyme phenylethanolamine N-methyl transferase (PNMT) and the content of adrenaline in the pheochromocytomas (n = 9), including 3 cases of the adrenaline-secreting type (one of the patients had bilateral pheochromocytomas), and in normal adrenal medullas (n = 7).	Epinephrine	191-201	phenylethanolamine N-methyltransferase	Homo sapiens	263-267
10604389-6	2000	RESULTS: In the 4 tissue specimens from 3 adrenaline-secreting pheochromocytomas, the contents of adrenaline and the PNMT mRNA expression were considerably greater than those of the normal adrenal medullas.	Epinephrine	42-52	phenylethanolamine N-methyltransferase	Homo sapiens	117-121
10604389-12	2000	CONCLUSIONS: These findings indicate that adrenaline production in adrenaline-secreting pheochromocytomas is primarily controlled by the level of PNMT gene expression, and that the gene expression may be enhanced by both cortisol and Egr-1.	Epinephrine	42-52	phenylethanolamine N-methyltransferase	Homo sapiens	146-150
10604389-12	2000	CONCLUSIONS: These findings indicate that adrenaline production in adrenaline-secreting pheochromocytomas is primarily controlled by the level of PNMT gene expression, and that the gene expression may be enhanced by both cortisol and Egr-1.	Epinephrine	42-52	early growth response 1	Homo sapiens	234-239
10604389-12	2000	CONCLUSIONS: These findings indicate that adrenaline production in adrenaline-secreting pheochromocytomas is primarily controlled by the level of PNMT gene expression, and that the gene expression may be enhanced by both cortisol and Egr-1.	Epinephrine	67-77	phenylethanolamine N-methyltransferase	Homo sapiens	146-150
10984077-9	2000	Insulin hypoglycemia increased plasma adrenaline levels, but the concentrations of MDA and the activities of GSH-Px and SOD were decreased.	Epinephrine	38-48	insulin	Homo sapiens	0-7
10915472-10	1999	The results demonstrated that PAF-stimulated platelet aggregation was significantly inhibited with SNP (10(-5) M) to 82% (p &lt; .05) of control and epinephrine and ADP mediated aggregation were not significantly affected.	Epinephrine	149-160	PCNA clamp associated factor	Homo sapiens	30-33
10567230-6	1999	The treatment of intact cells with phorbol ester or with adrenaline (epinephrine) plus propranolol increased calreticulin phosphorylation, which was blocked by the pretreatment of cells with the PKC-specific inhibitor Ro 31-8220.	Epinephrine	57-67	calreticulin	Rattus norvegicus	109-121
10567230-6	1999	The treatment of intact cells with phorbol ester or with adrenaline (epinephrine) plus propranolol increased calreticulin phosphorylation, which was blocked by the pretreatment of cells with the PKC-specific inhibitor Ro 31-8220.	Epinephrine	57-67	protein kinase C, alpha	Rattus norvegicus	195-198
10567230-6	1999	The treatment of intact cells with phorbol ester or with adrenaline (epinephrine) plus propranolol increased calreticulin phosphorylation, which was blocked by the pretreatment of cells with the PKC-specific inhibitor Ro 31-8220.	Epinephrine	69-80	calreticulin	Rattus norvegicus	109-121
10567230-6	1999	The treatment of intact cells with phorbol ester or with adrenaline (epinephrine) plus propranolol increased calreticulin phosphorylation, which was blocked by the pretreatment of cells with the PKC-specific inhibitor Ro 31-8220.	Epinephrine	69-80	protein kinase C, alpha	Rattus norvegicus	195-198
10585338-1	1999	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.	Epinephrine	126-137	tyrosine hydroxylase	Homo sapiens	12-32
10585338-1	1999	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the biosynthesis of the catecholamines dopamine, norepinephrine, and epinephrine.	Epinephrine	126-137	tyrosine hydroxylase	Homo sapiens	34-36
10622745-1	1999	The quantitative effects of an Asp79Asn mutation in the porcine alpha2A-adrenoceptor on adrenaline-mediated stimulation of the alpha subunit of individual members of the Gi family of G proteins were assessed by measuring GTP turnover number for fusion proteins between the wild type or mutated receptor and pertussis toxin-resistant forms of each of Gi1, Gi2 and Gi3.	Epinephrine	88-98	adrenoceptor alpha 2A	Homo sapiens	64-84
10651010-5	1999	The in vitro lipolytic response to epinephrine, isoproterenol, growth hormone (GH) and parathormone (PTH) decreased significantly (P&lt;0.01, P&lt;0.05, P&lt;0.01 and P&lt;0.01 respectively), as did the plasma concentration of free fatty acid (P&lt;0.01).	Epinephrine	35-46	parathyroid hormone	Homo sapiens	101-104
10636317-0	1999	Adrenaline upregulates monocyte L-selectin in vitro.	Epinephrine	0-10	selectin L	Homo sapiens	32-42
10636317-3	1999	This study investigates whether adrenaline increases the expression of L-selectin on monocytes, neutrophils and lymphocytes in vitro and whether these effects are mediated via beta-adrenoceptors.	Epinephrine	32-42	selectin L	Homo sapiens	71-81
10636317-10	1999	RESULTS: A significant increase in both the percentage of monocytes expressing L-selectin and mean channel fluorescence of L-selectin was evident with adrenaline in vitro (P &lt; 0.0001).	Epinephrine	151-161	selectin L	Homo sapiens	79-89
10636317-10	1999	RESULTS: A significant increase in both the percentage of monocytes expressing L-selectin and mean channel fluorescence of L-selectin was evident with adrenaline in vitro (P &lt; 0.0001).	Epinephrine	151-161	selectin L	Homo sapiens	123-133
10636317-11	1999	Maximal increases occurred at 100 nmol/l adrenaline when a 9% increase in the percentage of monocytes expressing L-selectin and a 23% increase in mean channel fluorescence were observed.	Epinephrine	41-51	selectin L	Homo sapiens	113-123
10636317-14	1999	CONCLUSIONS: Adrenaline upregulates the surface expression of L-selectin on monocytes in vitro, an effect which is partially mediated by beta-adrenoceptors.	Epinephrine	13-23	selectin L	Homo sapiens	62-72
10605950-13	1999	The next morning after exercise, the LPS-induced IL-8 production increased 137, 89, and 96%, respectively, in control, low-, and high-dose wine groups, probably due to a rise in epinephrine and activation of platelets.	Epinephrine	178-189	C-X-C motif chemokine ligand 8	Homo sapiens	49-53
10588509-6	1999	In blood of healthy volunteers, epinephrine reduced the LPS-stimulated synthesis of TNFalpha by 62.5% (P&lt; 0.0001), of IL-6 by 39% (P&lt; 0.0001), and of IL-1beta by 40% (P= 0.015), and increased the LPS-stimulated IL-10 production by 77.8% (P &lt; 0.0001).	Epinephrine	32-43	tumor necrosis factor	Homo sapiens	84-92
10519645-6	1999	The purified PLA2 inhibited ADP, collagen and epinephrine induced human platelet aggregation and the inhibition was both dose and time dependent.	Epinephrine	46-57	phospholipase A2 group IIA	Homo sapiens	13-17
10564704-1	1999	Chromogranin A (CgA) is a member of a family of highly acidic proteins, chromogranins, which are co-stored in the adrenergic neurons and paraneurons and co-released with adrenaline and noradrenaline (NAd) in response to adequate stimulation.	Epinephrine	170-180	chromogranin A	Rattus norvegicus	0-14
10588509-6	1999	In blood of healthy volunteers, epinephrine reduced the LPS-stimulated synthesis of TNFalpha by 62.5% (P&lt; 0.0001), of IL-6 by 39% (P&lt; 0.0001), and of IL-1beta by 40% (P= 0.015), and increased the LPS-stimulated IL-10 production by 77.8% (P &lt; 0.0001).	Epinephrine	32-43	interleukin 6	Homo sapiens	121-125
10588509-6	1999	In blood of healthy volunteers, epinephrine reduced the LPS-stimulated synthesis of TNFalpha by 62.5% (P&lt; 0.0001), of IL-6 by 39% (P&lt; 0.0001), and of IL-1beta by 40% (P= 0.015), and increased the LPS-stimulated IL-10 production by 77.8% (P &lt; 0.0001).	Epinephrine	32-43	interleukin 1 beta	Homo sapiens	156-164
10588509-6	1999	In blood of healthy volunteers, epinephrine reduced the LPS-stimulated synthesis of TNFalpha by 62.5% (P&lt; 0.0001), of IL-6 by 39% (P&lt; 0.0001), and of IL-1beta by 40% (P= 0.015), and increased the LPS-stimulated IL-10 production by 77.8% (P &lt; 0.0001).	Epinephrine	32-43	interleukin 10	Homo sapiens	217-222
10588509-9	1999	Interestingly, epinephrine suppressed the IL-1beta production by 73% (P &lt; 0.0001) in blood of patients in prolonged septic shock, which was twice as much as in blood samples of healthy volunteers.	Epinephrine	15-26	interleukin 1 beta	Homo sapiens	42-50
10597901-10	1999	Adrenaline and noradrenaline did not significantly prevent the inactivation of ADH and very slightly inhibited GAPDH.	Epinephrine	0-10	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	111-116
10548496-1	1999	Incubation of rat parotid tissue with 10 microM epinephrine resulted in a transient and marked trafficking of aquaporin-5 (AQP5) from intracellular membranes to the apical plasma membrane (APM) that was maximal at 1 min.	Epinephrine	48-59	aquaporin 5	Rattus norvegicus	110-121
10548496-1	1999	Incubation of rat parotid tissue with 10 microM epinephrine resulted in a transient and marked trafficking of aquaporin-5 (AQP5) from intracellular membranes to the apical plasma membrane (APM) that was maximal at 1 min.	Epinephrine	48-59	aquaporin 5	Rattus norvegicus	123-127
10548496-3	1999	Furthermore, the epinephrine-induced trafficking of AQP5 was inhibited by phospholipase C inhibitor U73122 as well as dantrolene and TMB-8, both of which inhibit the release of Ca(2+) from intracellular stores.	Epinephrine	17-28	aquaporin 5	Rattus norvegicus	52-56
10564704-1	1999	Chromogranin A (CgA) is a member of a family of highly acidic proteins, chromogranins, which are co-stored in the adrenergic neurons and paraneurons and co-released with adrenaline and noradrenaline (NAd) in response to adequate stimulation.	Epinephrine	170-180	chromogranin A	Rattus norvegicus	16-19
10543947-3	1999	SULT1A3 specifically sulfonates catecholamines such as dopamine, adrenaline and noradrenaline.	Epinephrine	65-75	sulfotransferase family 1A member 3	Homo sapiens	0-7
10566656-11	1999	Importantly, epinephrine dose dependently inhibited PAI-1 parameters, an effect that was reproduced by isoproterenol.	Epinephrine	13-24	serpin family E member 1	Homo sapiens	52-57
10566660-4	1999	We measured glycerol flux, using a nonradioactive tracer dilution approach, to analyze the lipolytic response to epinephrine in 6 patients with Gs deficiency and PTH resistance and compared it to six age-matched normal controls and nine massively obese children.	Epinephrine	113-124	parathyroid hormone	Homo sapiens	162-165
10522874-2	1999	BACKGROUND: AADC is a required enzyme in dopamine, norepinephrine, epinephrine, and serotonin biosynthesis.	Epinephrine	54-65	dopa decarboxylase	Homo sapiens	12-16
10572943-0	1999	Adrenaline-mediated glycogen phosphorylase activation is enhanced in rat soleus muscle with increased glycogen content.	Epinephrine	0-10	glycogen phosphorylase L	Rattus norvegicus	20-42
10572943-6	1999	Adrenaline (10(-6) M) transformed about 20% and 35% (P &lt; 0.01) of glycogen phosphorylase to the a form in soleus with normal and high glycogen content, respectively.	Epinephrine	0-10	glycogen phosphorylase L	Rattus norvegicus	69-91
10572943-7	1999	In epitrochlearis, adrenaline stimulation transformed about 80% of glycogen phosphorylase to the a form.	Epinephrine	19-29	glycogen phosphorylase L	Rattus norvegicus	67-89
10572943-9	1999	In conclusion, adrenaline-mediated glycogen phosphorylase activation is enhanced in rat soleus muscles with increased glycogen content.	Epinephrine	15-25	glycogen phosphorylase L	Rattus norvegicus	35-57
10572943-10	1999	Glycogen phosphorylase activation during adrenaline stimulation was much higher in epitrochlearis than in soleus muscles with a similar content of glycogen.	Epinephrine	41-51	glycogen phosphorylase L	Rattus norvegicus	0-22
10499537-4	1999	Mice lacking dopamine beta-hydroxylase (Dbh-/-), the enzyme responsible for synthesizing norepinephrine and epinephrine from dopamine, were treated with leptin (20 microg/g body weight/day) for 3 days before they were euthanized.	Epinephrine	92-103	dopamine beta hydroxylase	Mus musculus	40-47
10369791-2	1999	We compared the effects of mental stress, dynamic exercise and adrenaline infusion on platelet sensitivity to thrombin using flow-cytometric analysis of platelet fibrinogen binding in whole blood, and platelet aggregability using filtragometry ex vivo, in healthy volunteers.	Epinephrine	63-73	coagulation factor II, thrombin	Homo sapiens	110-118
10544922-5	1999	In the present study, we supplemented the P2Y1 mediated Gq signaling pathway with inhibition of the platelet adenylyl cyclase by using SQ22536 or dideoxyadenosine, or by selective activation of the alpha2A adrenoceptors with epinephrine.	Epinephrine	225-236	purinergic receptor P2Y1	Homo sapiens	42-46
10544922-6	1999	Although SQ22536, dideoxyadenosine, and epinephrine reduced the cAMP levels, only epinephrine could mimic the P2TAC receptor mediated signaling events, suggesting that reduction in basal cAMP levels does not directly contribute to ADP-induced platelet activation.	Epinephrine	82-93	purinergic receptor P2Y12	Homo sapiens	110-115
10498856-6	1999	The sensitivity to killing by epinephrine is reported here for four different CF cell lines, three normal cell lines, and two CF epithelial cell lines complemented with wild-type (wt) CF transmembrane conductance regulator (CFTR) cDNA.	Epinephrine	30-41	CF transmembrane conductance regulator	Homo sapiens	184-222
10498856-6	1999	The sensitivity to killing by epinephrine is reported here for four different CF cell lines, three normal cell lines, and two CF epithelial cell lines complemented with wild-type (wt) CF transmembrane conductance regulator (CFTR) cDNA.	Epinephrine	30-41	CF transmembrane conductance regulator	Homo sapiens	224-228
10580367-3	1999	administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad).	Epinephrine	119-129	interleukin 1 beta	Rattus norvegicus	13-30
10580367-3	1999	administered interleukin-1beta (IL-1beta) (100 ng/animal) slightly, but significantly, elevated the plasma level of noradrenaline (NA), but not the level of adrenaline (Ad).	Epinephrine	119-129	interleukin 1 beta	Rattus norvegicus	32-40
10430789-11	1999	CONCLUSIONS: The secretion of GH and epinephrine is gender-dependent and differs during the daytime in a reciprocal manner, with higher GH and lower epinephrine in women than in men.	Epinephrine	37-48	growth hormone 1	Homo sapiens	136-138
10430789-11	1999	CONCLUSIONS: The secretion of GH and epinephrine is gender-dependent and differs during the daytime in a reciprocal manner, with higher GH and lower epinephrine in women than in men.	Epinephrine	149-160	growth hormone 1	Homo sapiens	30-32
10470765-1	1999	OBJECTIVE: Intravenous administration of vasopressin during cardiopulmonary resuscitation (CPR) may be more effective than optimal doses of epinephrine.	Epinephrine	140-151	vasopressin	Sus scrofa	41-52
10405323-4	1999	Thrombin, a thrombin receptor agonist peptide, a thromboxane A(2) analogue, collagen, crosslinking the glycoprotein VI, ADP, and epinephrine, but not phorbol 12, 13-dibutyrate activated p38.	Epinephrine	129-140	coagulation factor II, thrombin	Homo sapiens	0-8
10405323-4	1999	Thrombin, a thrombin receptor agonist peptide, a thromboxane A(2) analogue, collagen, crosslinking the glycoprotein VI, ADP, and epinephrine, but not phorbol 12, 13-dibutyrate activated p38.	Epinephrine	129-140	coagulation factor II, thrombin	Homo sapiens	12-20
10491292-3	1999	In contrast, adrenaline, acetylcholine, histamine and CGRP induced only low amount of SP from cultured normal human KCs.	Epinephrine	13-23	tachykinin precursor 1	Homo sapiens	86-88
10484381-13	1999	In conclusion, epinephrine stimulated the Na+-K+-2Cl- cotransporter in a process mediated by beta1- and beta2-receptors and modulated by intracellular Ca2+ liberation.	Epinephrine	15-26	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	93-98
10484381-13	1999	In conclusion, epinephrine stimulated the Na+-K+-2Cl- cotransporter in a process mediated by beta1- and beta2-receptors and modulated by intracellular Ca2+ liberation.	Epinephrine	15-26	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	104-109
10487964-5	1999	Oxidation and peroxidation products of membrane constituents chiefly lipids were estimated as TBARS, SOD by its activity to inhibit auto-oxidation of epinephrine, GP by estimating the reduction in the level of GSH and GSH by its colour reaction with 5,5"-dithio bis (2-nitro) benzoic acid (DTNB).	Epinephrine	150-161	superoxide dismutase 1	Homo sapiens	101-104
10480609-6	1999	A single injection of leptin (0.25-1.0 mg i.v./rat or 0.5-2.0 pg i.c.v./rat) increased plasma norepinephrine (NE) and epinephrine (EPI) concentrations in a dose-dependent manner.	Epinephrine	97-108	leptin	Rattus norvegicus	22-28
10480609-6	1999	A single injection of leptin (0.25-1.0 mg i.v./rat or 0.5-2.0 pg i.c.v./rat) increased plasma norepinephrine (NE) and epinephrine (EPI) concentrations in a dose-dependent manner.	Epinephrine	131-134	leptin	Rattus norvegicus	22-28
10677042-3	1999	Here, we show that epinephrine-induced mechanical and thermal hyperalgesia and acetic acid-associated hyperalgesia are markedly attenuated in PKCepsilon mutant mice, but baseline nociceptive thresholds are normal.	Epinephrine	19-30	protein kinase C, epsilon	Mus musculus	142-152
10677042-4	1999	Moreover, epinephrine-, carrageenan-, and nerve growth factor- (NGF-) induced hyperalgesia in normal rats, and epinephrine-induced enhancement of tetrodotoxin-resistant Na+ current (TTX-R I(Na)) in cultured rat dorsal root ganglion (DRG) neurons, are inhibited by a PKCepsilon-selective inhibitor peptide.	Epinephrine	10-21	protein kinase C, epsilon	Mus musculus	266-276
10677042-4	1999	Moreover, epinephrine-, carrageenan-, and nerve growth factor- (NGF-) induced hyperalgesia in normal rats, and epinephrine-induced enhancement of tetrodotoxin-resistant Na+ current (TTX-R I(Na)) in cultured rat dorsal root ganglion (DRG) neurons, are inhibited by a PKCepsilon-selective inhibitor peptide.	Epinephrine	111-122	protein kinase C, epsilon	Mus musculus	266-276
10425201-6	1999	Murine recombinant leptin (&gt;==50 nM) strongly induced the release of both epinephrine (E) and norepinephrine (NE) from chromaffin cells.	Epinephrine	77-88	leptin	Mus musculus	19-25
10455322-6	1999	The effect of adrenaline on the response to thrombin in this vascular bed was also investigated.	Epinephrine	14-24	prothrombin	Oryctolagus cuniculus	44-52
10425466-4	1999	General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin.	Epinephrine	49-60	glucagon	Rattus norvegicus	92-97
10425466-4	1999	General stimulation of adrenergic receptors with epinephrine (10(-7) M) induced significant GLP-1 and PYY secretions (94+/-38 and 257+/-59 fmol/8 min respectively) which were abolished upon propranolol (10(-7) M) pretreatment and strongly decreased upon infusion with 10(-8) M prazosin.	Epinephrine	49-60	peptide YY	Rattus norvegicus	102-105
10478575-0	1999	Adrenaline influences the release of interleukin-6 from murine pituicytes: role of beta2-adrenoceptors.	Epinephrine	0-10	interleukin 6	Mus musculus	37-50
10478575-1	1999	In this study, we examined the effect of adrenaline and interleukin-1beta on interleukin-6 secretion from cultured murine neurohypophyseal cells.	Epinephrine	41-51	interleukin 6	Mus musculus	77-90
10478575-6	1999	Incubation with adrenaline (10(-6) M) or interleukin-1beta (11 pM) induced maximal secretion of interleukin-6, resulting in a 2.2-fold and 19.8-fold increase, respectively (P&lt;0.01).	Epinephrine	16-26	interleukin 6	Mus musculus	96-109
10357937-7	1999	However, GR mutant mice lack the adrenaline-synthesizing enzyme PNMT and secretogranin II.	Epinephrine	33-43	nuclear receptor subfamily 3, group C, member 1	Mus musculus	9-11
10357937-7	1999	However, GR mutant mice lack the adrenaline-synthesizing enzyme PNMT and secretogranin II.	Epinephrine	33-43	phenylethanolamine-N-methyltransferase	Mus musculus	64-68
10369791-5	1999	Adrenaline infusion enhanced thrombin-induced platelet fibrinogen binding and platelet aggregability (P&lt;0.05), and elevated thrombin-antithrombin complexes (P&lt;0.05), whereas F1+2 and fibrinopeptide A levels were not significantly affected.	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	29-37
10369791-5	1999	Adrenaline infusion enhanced thrombin-induced platelet fibrinogen binding and platelet aggregability (P&lt;0.05), and elevated thrombin-antithrombin complexes (P&lt;0.05), whereas F1+2 and fibrinopeptide A levels were not significantly affected.	Epinephrine	0-10	fibrinogen beta chain	Homo sapiens	55-65
10369791-5	1999	Adrenaline infusion enhanced thrombin-induced platelet fibrinogen binding and platelet aggregability (P&lt;0.05), and elevated thrombin-antithrombin complexes (P&lt;0.05), whereas F1+2 and fibrinopeptide A levels were not significantly affected.	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	127-135
10385412-0	1999	Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells.	Epinephrine	123-134	mitogen-activated protein kinase 14	Mus musculus	47-50
10385412-6	1999	The MEK inhibitor PD98059, blocked ERK2 activity induced by epinephrine but had no effect on the stimulation of ALP activity.	Epinephrine	60-71	midkine	Mus musculus	4-7
10385412-6	1999	The MEK inhibitor PD98059, blocked ERK2 activity induced by epinephrine but had no effect on the stimulation of ALP activity.	Epinephrine	60-71	mitogen-activated protein kinase 1	Mus musculus	35-39
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Epinephrine	152-162	solute carrier family 22 member 1	Homo sapiens	43-71
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Epinephrine	152-162	solute carrier family 22 member 1	Homo sapiens	73-77
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Epinephrine	152-162	solute carrier family 22 member 3	Homo sapiens	90-125
10385678-1	1999	The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and 5-hydroxytryptamine as substrates and hence qualify as non-neuronal monoamine transporters.	Epinephrine	152-162	solute carrier family 22 member 3	Homo sapiens	127-130
10443582-1	1999	Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline.	Epinephrine	109-119	adrenoceptor alpha 1D	Homo sapiens	0-6
10444314-8	1999	We conclude that before birth, adrenaline synthesis may be suppressed by a novel direct, or indirect, inhibitory effect of glucocorticoids on PNMT mRNA expression.	Epinephrine	31-41	phenylethanolamine N-methyltransferase	Ovis aries	142-146
10443582-1	1999	Alpha1-adrenoceptors are one of three subfamilies of receptors (alpha1, alpha2, beta) mediating responses to adrenaline and noradrenaline.	Epinephrine	109-119	adrenoceptor alpha 1D	Homo sapiens	64-70
10359844-0	1999	Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine.	Epinephrine	81-92	corticotropin releasing hormone	Homo sapiens	0-31
10358008-10	1999	beta2-AR -/- mice become hypertensive during exercise and exhibit a greater hypertensive response to epinephrine compared with wild type mice.	Epinephrine	101-112	adrenergic receptor, beta 2	Mus musculus	0-8
10404350-6	1999	Plasma renin activity (PRA) was increased after the first epinephrine application (3.0 +/- 0.5 to 6.4 +/- 0.9 ng angiotensin I (AI)/mL/h; P &lt; .05), followed by a return to control levels.	Epinephrine	58-69	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	7-12
10333490-0	1999	Expression of hormone-sensitive lipase and its regulation by adrenaline in skeletal muscle.	Epinephrine	61-71	lipase E, hormone sensitive type	Homo sapiens	14-38
10333490-8	1999	The results indicate that HSL is present in skeletal muscle and is stimulated by adrenaline via beta-adrenergic activation of cAMP-dependent protein kinase.	Epinephrine	81-91	lipase E, hormone sensitive type	Homo sapiens	26-29
10338466-7	1999	CONCLUSIONS: Mice that lack the ability to generate NE or epinephrine show increased contractility associated primarily with a decrease in the level of betaARK1 protein and kinase activity.	Epinephrine	58-69	G protein-coupled receptor kinase 2	Mus musculus	152-160
10233893-4	1999	Activation of human platelets with thrombin, a stable thromboxane A2 analog STA2, epinephrine, and serotonin resulted in an increase in MBS phosphorylation, and the agonist-induced MBS phosphorylation was prevented by pretreatment with the respective receptor antagonist.	Epinephrine	82-93	coagulation factor II, thrombin	Homo sapiens	35-43
10337850-5	1999	Correlation analysis indicated a significant association of leptin with epinephrine in normal subjects (r = -.81, P &lt; .0001), but not in pheochromocytoma patients.	Epinephrine	72-83	leptin	Homo sapiens	60-66
10400340-1	1999	In order to determine the function of epinephrine (Epi) in the central nervous system, we have targeted the enzyme that catalyzes the final step in the biosynthesis of Epi, phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28).	Epinephrine	38-49	phenylethanolamine N-methyltransferase	Homo sapiens	173-211
10400340-1	1999	In order to determine the function of epinephrine (Epi) in the central nervous system, we have targeted the enzyme that catalyzes the final step in the biosynthesis of Epi, phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28).	Epinephrine	38-49	phenylethanolamine N-methyltransferase	Homo sapiens	213-217
10329804-1	1999	All bronchodilating beta2-adrenoceptor agonists in current clinical use are derivatives of adrenaline and are available as racemates.	Epinephrine	91-101	beta-2 adrenergic receptor	Cavia porcellus	20-38
10224140-10	1999	Acidic metabolites of neurotransmitters derived from dopamine, epinephrine, norepinephrine, and serotonin inhibited the uptake of estrone sulfate via OAT3.	Epinephrine	63-74	solute carrier family 22 member 8	Rattus norvegicus	150-154
10216081-9	1999	GATA-1-deficient platelets show abnormal ultrastructure, reminiscent of the megakaryocytes from which they are derived, and exhibit modest but selective defects in platelet activation in response to thrombin or to the combination of adenosine diphosphate (ADP) and epinephrine.	Epinephrine	265-276	GATA binding protein 1	Mus musculus	0-6
10233122-5	1999	The Tc/Tsk contribution ratio was relatively lower for thermal comfort (1:1) than for vasomotor changes (3:1; P = 0.008), metabolic heat production (3.6:1; P = 0.001), norepinephrine (1.8:1; P = 0.03), and epinephrine (3:1; P = 0.006) responses.	Epinephrine	171-182	tsukushi, small leucine rich proteoglycan	Homo sapiens	7-10
10232499-4	1999	We showed that NOS-2 mRNA expression and NO production were induced by stimulation with epinephrine, dopamine, endothelin-1, and angiotensin II, both in monocytes and HUVEC.	Epinephrine	88-99	nitric oxide synthase 2	Homo sapiens	15-20
10432564-2	1999	It was stated that the appearance of this product of adrenaline oxidation, which was not reported earlier, is considerably more rapid than formation of adrenochrome (absorbtion at 480 nm) and is inhibited by superoxide dismutase (SOD).	Epinephrine	53-63	superoxide dismutase 1	Homo sapiens	208-228
10432564-2	1999	It was stated that the appearance of this product of adrenaline oxidation, which was not reported earlier, is considerably more rapid than formation of adrenochrome (absorbtion at 480 nm) and is inhibited by superoxide dismutase (SOD).	Epinephrine	53-63	superoxide dismutase 1	Homo sapiens	230-233
10195947-9	1999	The presence of 1 or 2 PlA2 alleles was associated with increased platelet aggregability as indicated by incrementally lower threshold concentrations for epinephrine and ADP.	Epinephrine	154-165	phospholipase A2 group IIA	Homo sapiens	23-27
10195947-10	1999	For epinephrine, the mean concentrations were 0.9 micromol/L (0.9 to 1.0) for homozygous PlA1, 0.7 mmol/L (0.7 to 0.9) for the heterozygous PlA1/PlA2, and 0.6 micromol/L (0.4 to 1.0) for homozygous PlA2 individuals, P=0.009.	Epinephrine	4-15	POU class 2 homeobox 3	Homo sapiens	89-93
10194528-3	1999	Using intact capsular tissue it was found that VIP caused a dose-dependent increase in aldosterone secretion, with a concomitant increase in both adrenaline and noradrenaline release.	Epinephrine	146-156	vasoactive intestinal peptide	Rattus norvegicus	47-50
10344529-14	1999	On the one hand, uptake2 prefers adrenaline among the endogenous catecholamines, whereas rOCT1 has similar affinity for adrenaline and dopamine.	Epinephrine	120-130	solute carrier family 22 member 1	Rattus norvegicus	89-94
10206438-0	1999	Epinephrine stimulates human muscle lipoprotein lipase activity in vivo.	Epinephrine	0-11	lipoprotein lipase	Homo sapiens	36-54
10206438-7	1999	Epinephrine stimulated SM-LPL activity by 21.8%+/-6.8% above basal levels from 1.44+/-0.25 to 1.69+/-0.28 micromol free fatty acid (FFA)/h/g muscle (P&lt;.02), increased plasma FFA 270% from 0.147 to 0.544 mmol/L (P&lt;.05), and increased lipid oxidation 45% from 4.37 to 6.36 mg/kg/min (P&lt;.05).	Epinephrine	0-11	lipoprotein lipase	Homo sapiens	26-29
10206438-10	1999	Overall, the results demonstrate that epinephrine is able to stimulate SM-LPL activity in humans, and thus may have opposite effects on adipose tissue and SM-LPL activity.	Epinephrine	38-49	lipoprotein lipase	Homo sapiens	74-77
10206438-10	1999	Overall, the results demonstrate that epinephrine is able to stimulate SM-LPL activity in humans, and thus may have opposite effects on adipose tissue and SM-LPL activity.	Epinephrine	38-49	lipoprotein lipase	Homo sapiens	158-161
10216531-9	1999	Epinephrine-tolerant animals had higher levels of TNF-alpha, IL-6, and IL-12 than the controls did.	Epinephrine	0-11	tumor necrosis factor	Mus musculus	50-59
10216531-9	1999	Epinephrine-tolerant animals had higher levels of TNF-alpha, IL-6, and IL-12 than the controls did.	Epinephrine	0-11	interleukin 6	Mus musculus	61-65
10216531-10	1999	CONCLUSION: Epinephrine tolerance primes for an exaggerated release of TNF-alpha, IL-6, and IL-12 in response to lipopolysaccharide challenge, suggesting anti-inflammatory and immunosuppressive effects by epinephrine.	Epinephrine	12-23	tumor necrosis factor	Mus musculus	71-80
10216531-10	1999	CONCLUSION: Epinephrine tolerance primes for an exaggerated release of TNF-alpha, IL-6, and IL-12 in response to lipopolysaccharide challenge, suggesting anti-inflammatory and immunosuppressive effects by epinephrine.	Epinephrine	12-23	interleukin 6	Mus musculus	82-86
10101261-11	1999	Epinephrine led to greater phosphorylation of cPLA2, resulting in an electrophoretic mobility shift for all three cell lines, so inadequate p42/44 MAPKs stimulation was not responsible for the weaker stimulation of cPLA2 in CHO-2C cells.	Epinephrine	0-11	phospholipase A2 group IVA	Rattus norvegicus	46-51
10231022-4	1999	The synergistic interaction of 5-HT (1-5 microM) and epinephrine (0.5-2 microM) was inhibited by alpha2-adrenoceptor blocker (yohimbine; IC50= 0.4 microM), calcium channel blockers (verapamil and diltiazem with IC50 of 10 and 48 mM, respectively), PLC inhibitor (U73122; IC50=6 microM) and nitric oxide (NO) donor, SNAP (IC50=1.6 microM)).	Epinephrine	53-64	heparan sulfate proteoglycan 2	Homo sapiens	248-251
10064798-2	1999	Immunolabelling for tyrosine hydroxylase (TH), dopamine beta-hydroxylase and phenylethanolamine-N-methyl transferase (PNMT) occurred in all SIF cells of the PCG, thus demonstrating the presence of all the enzymes required for adrenaline biosynthesis.	Epinephrine	226-236	tyrosine hydroxylase	Rattus norvegicus	20-40
10218899-0	1999	The new chromogranin-like protein NESP55 is preferentially localized in adrenaline-synthesizing cells of the bovine and rat adrenal medulla.	Epinephrine	72-82	GNAS complex locus	Bos taurus	34-40
10218899-5	1999	The distribution of NESP55 mRNA was similar to preproenkephalin mRNA which previously was shown to be confined to adrenaline-producing cells of the adrenal medulla.	Epinephrine	114-124	GNAS complex locus	Rattus norvegicus	20-26
10064798-2	1999	Immunolabelling for tyrosine hydroxylase (TH), dopamine beta-hydroxylase and phenylethanolamine-N-methyl transferase (PNMT) occurred in all SIF cells of the PCG, thus demonstrating the presence of all the enzymes required for adrenaline biosynthesis.	Epinephrine	226-236	phenylethanolamine-N-methyltransferase	Rattus norvegicus	118-122
10064798-3	1999	Adrenaline levels were undetectable in the PCG but to test the hypothesis that PNMT is active in SIF cells, catecholamines were measured in ganglia of rats pretreated with pargyline, an inhibitor of the monoamine oxidase, the major enzyme involved in the catecholamine degradation.	Epinephrine	0-10	phenylethanolamine-N-methyltransferase	Rattus norvegicus	79-83
10079965-2	1999	Catecholamine (dopamine, norepinephrine, and epinephrine) biosynthesis is regulated by tyrosine hydroxylase (TH).	Epinephrine	28-39	tyrosine hydroxylase	Homo sapiens	87-107
10079965-2	1999	Catecholamine (dopamine, norepinephrine, and epinephrine) biosynthesis is regulated by tyrosine hydroxylase (TH).	Epinephrine	28-39	tyrosine hydroxylase	Homo sapiens	109-111
10075051-4	1999	MEASUREMENTS AND MAIN RESULTS: Compared with control myocytes, TNF-alpha-exposed myocytes stimulated with increasing concentrations of epinephrine demonstrated a decreased peak augmentation of contractility (p&lt;.0001 analysis of variance).	Epinephrine	135-146	tumor necrosis factor	Rattus norvegicus	63-72
9927320-8	1999	Because catecholamines increase intracellular cAMP levels, we investigated the effects of dopamine, epinephrine, and norepinephrine on IL-6 release.	Epinephrine	100-111	interleukin 6	Rattus norvegicus	135-139
9884381-10	1999	CONCLUSIONS: Norepinephrine and epinephrine hasten human ventricular relaxation and promote phosphorylation of implicated proteins through both beta1- and beta2-adrenergic receptors, thereby potentially improving diastolic function.	Epinephrine	16-27	adrenoceptor beta 1	Homo sapiens	144-181
10636470-1	1999	Expression of the gene encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) is regulated by hormonal and neural stimuli.	Epinephrine	36-47	phenylethanolamine N-methyltransferase	Bos taurus	68-106
10636470-1	1999	Expression of the gene encoding the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) is regulated by hormonal and neural stimuli.	Epinephrine	36-47	phenylethanolamine N-methyltransferase	Bos taurus	108-112
10379925-9	1999	There was little response to phenylephrine and epinephrine in ILPA and SPA.	Epinephrine	47-58	pulmonary surfactant-associated protein A	Oryctolagus cuniculus	71-74
9927627-6	1999	The epinephrine-induced internalization of the constitutively active A293E mutant was significantly higher than that of the wild-type alpha-1b AR.	Epinephrine	4-15	adrenoceptor alpha 1B	Homo sapiens	134-145
9878736-10	1999	Taken together, these findings indicate that IL-1beta impairs lung clearance of MADB106 tumor cells via the actions of adrenal catecholamines, most likely epinephrine, acting at beta-adrenergic receptors in the periphery.	Epinephrine	155-166	interleukin 1 beta	Rattus norvegicus	45-53
9888838-1	1999	7-Substituted-1,2,3,4-tetrahydroisoquinolines (7-substituted-THIQs) are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28), the enzyme involved in the biosynthesis of epinephrine.	Epinephrine	196-207	phenylethanolamine N-methyltransferase	Homo sapiens	93-131
9888838-1	1999	7-Substituted-1,2,3,4-tetrahydroisoquinolines (7-substituted-THIQs) are potent inhibitors of phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28), the enzyme involved in the biosynthesis of epinephrine.	Epinephrine	196-207	phenylethanolamine N-methyltransferase	Homo sapiens	133-137
10077231-9	1999	The pA2 value for the specific beta2-adrenoceptor antagonist ICI-118,551 (8.7+/-0.4) as an antagonist of the adrenaline-stimulated cyclic AMP generation were 3 units higher than the value for the betaI-adrenoceptor antagonist atenolol (5.6+/-0.3).	Epinephrine	109-119	adrenergic receptor, beta 2	Mus musculus	31-49
9915270-9	1999	In addition, sequential measurements of neurohormonal mediator levels in patients receiving calcitriol showed that plasma renin (18.5 +/- 12.7 v 12.3 +/- 11.0 pg/mL; P = 0.007), angiotensin II (AT II; 79.7 +/- 48.6 v 47.2 +/- 45.7 pg/mL; P = 0.001), and atrial natriuretic peptide (ANP; 16.6 +/- 9.7 v 12.2 +/- 4.4 pg/mL; P = 0.03) levels significantly decreased, whereas antidiuretic hormone (ADH), epinephrine, and norepinephrine levels did not change significantly.	Epinephrine	400-411	renin	Homo sapiens	122-127
10754379-2	1999	All 3 drugs inhibited platelet aggregation response to ADP, collagen, epinephrine and arachidonic acid (p &lt; 0.05), but not to ristocetin.	Epinephrine	70-81	paired box 5	Homo sapiens	0-5
10077231-11	1999	Treatment of the cells with adrenaline and forskolin evoked a 3 fold increase in the activity of serotonin N-acetyltransferase with the peak occurring 6 h after stimulation.	Epinephrine	28-38	arylalkylamine N-acetyltransferase	Mus musculus	97-126
10077236-18	1999	Exposure to a relatively low CEC concentration (3 microM) abolished the maximum response to adrenaline suggesting that this response was mediated by an alpha1B-adrenoceptor subtype.	Epinephrine	92-102	adrenoceptor alpha 1B	Homo sapiens	152-172
10442564-7	1999	LPL activity in adipose and skeletal muscle tissue is generally regulated in a reciprocal manner by, for example, fasting, feeding, insulin and epinephrine.	Epinephrine	144-155	lipoprotein lipase	Homo sapiens	0-3
9916132-7	1999	FFA release from isolated adipose tissue in response to epinephrine was 68% lower in C/EBPbeta-/- mice than in control animals; however, N6,O2"-dibutyryladenosine (Bt2) cAMP stimulated a twofold increase in FFA release in C/EBPbeta-/- compared with no further increase in wild-type mice.	Epinephrine	56-67	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	85-94
9831823-2	1999	Adrenergic agonists and antagonists showed activation and inhibition constants consistent with the presence of beta2-receptors: Ka of isoproterenol &lt; epinephrine &lt; norepinephrine &lt; phenylephrine; Ki of timolol &lt; betaxolol &lt; celiprolol &lt; atenolol.	Epinephrine	153-164	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	111-116
10363831-6	1999	Bulbospinal neurons in the rostro-ventro-lateral medulla were also examined immunocytochemically for the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase.	Epinephrine	105-115	phenylethanolamine-N-methyltransferase	Rattus norvegicus	136-174
10363831-13	1999	The majority of these axotomized rostro-ventro-lateral medulla neurons maintain their immunopositivity for the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase.	Epinephrine	111-121	phenylethanolamine-N-methyltransferase	Rattus norvegicus	142-180
10579570-3	1999	Central corticotropin-releasing hormone receptor blockade reduced the early increases in plasma epinephrine and dopamine, but not norepinephrine, during stress.	Epinephrine	96-107	corticotropin releasing hormone	Rattus norvegicus	8-39
10348705-0	1999	Epinephrine promotes IL-8 production in human leukocytes via an effect on platelets.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	21-25
10477081-6	1999	PACAP increased tyrosine hydroxylase and dopamine beta-hydroxylase activities, but slightly lowered phenylethanolamine N-methyltransferase activity, resulting in a preferential rise in norepinephrine over epinephrine.	Epinephrine	188-199	adenylate cyclase activating polypeptide 1	Bos taurus	0-5
10348705-2	1999	Epinephrine has been reported by several groups to suppress activation of monocytes in response to LPS, and the aim of the present study was to examine the effect of epinephrine on LPS induced IL-8 production using whole blood as a model system.	Epinephrine	166-177	C-X-C motif chemokine ligand 8	Homo sapiens	193-197
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	34-38
10348705-3	1999	Epinephrine increased LPS induced IL-8 production in a dose-dependent manner in the whole concentration range (0.001-100 microM) and 1 microM epinephrine increased IL-8 levels with 125%.	Epinephrine	142-153	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
10348705-5	1999	The potentiating effect of epinephrine was mediated by blood platelets, since IL-8 levels in samples containing platelets and stimulated with LPS and epinephrine (1-100 microM) were significantly higher (p&lt;0.05) than in control samples containing no platelets.	Epinephrine	27-38	C-X-C motif chemokine ligand 8	Homo sapiens	78-82
10348705-8	1999	We demonstrate for the first time that epinephrine promotes LPS induced production of IL-8 in whole blood via an effect on blood platelets.	Epinephrine	39-50	C-X-C motif chemokine ligand 8	Homo sapiens	86-90
10205832-1	1999	At present, photochemical detection of SOD-activity is used in most cases, where superoxide production is based on the NADPH oxidase activity or autooxidation of some substances, for instance, adrenaline.	Epinephrine	193-203	superoxide dismutase 1	Homo sapiens	39-42
9822156-2	1998	Introduction of the TH transgene directed by the dopamine beta-hydroxylase gene promoter into TH knockout mice restored noradrenaline and adrenaline synthesis, preventing perinatal lethality and cardiac dysfunction in the knockout mice.	Epinephrine	123-133	tyrosine hydroxylase	Mus musculus	20-22
9822156-2	1998	Introduction of the TH transgene directed by the dopamine beta-hydroxylase gene promoter into TH knockout mice restored noradrenaline and adrenaline synthesis, preventing perinatal lethality and cardiac dysfunction in the knockout mice.	Epinephrine	123-133	dopamine beta hydroxylase	Mus musculus	49-74
9822156-2	1998	Introduction of the TH transgene directed by the dopamine beta-hydroxylase gene promoter into TH knockout mice restored noradrenaline and adrenaline synthesis, preventing perinatal lethality and cardiac dysfunction in the knockout mice.	Epinephrine	123-133	tyrosine hydroxylase	Mus musculus	94-96
9814985-6	1998	Pretreatment of cell monolayers with Lipofectin plus antisense oligonucleotide to PKC-epsilon for 48 h prevented stimulation of CFTR with (-)-epinephrine, reduced PKC-epsilon activity in unstimulated cells by 52.1%, and decreased PKC-epsilon mass by 76.1% but did not affect hormone-activated protein kinase A activity.	Epinephrine	138-153	protein kinase C epsilon	Homo sapiens	82-93
9843377-2	1998	In transfected CHO cells expressing the human alpha2AAR, a 40.1 +/- 3.3% downregulation of Galphai2 protein occurred after 24 h of exposure of the cells to epinephrine, which was not accompanied by a decrease in Galphai2 mRNA.	Epinephrine	156-167	adrenoceptor alpha 2A	Homo sapiens	46-55
10064789-2	1999	COMT activity was evaluated by the ability to methylate adrenaline (0.1 to 2000 microM) to metanephrine in the presence of a saturating concentration of the methyl donor (S-adenosyl-l-methionine).	Epinephrine	56-66	catechol-O-methyltransferase	Homo sapiens	0-4
9834044-14	1998	Cardiac beta2-receptors mediate most of the chronotropic and inotropic responses to epinephrine in both patients with hypertension and heart transplant patients.	Epinephrine	84-95	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	8-13
10461011-4	1998	First, in platelets that were stimulated to spread over fibrin or fibrinogen surfaces with adrenaline, addition of thrombin and CaCl(2) caused a potent Ca(2+) signal that in about 30% of the cells was accompanied by exposure of PS.	Epinephrine	91-101	coagulation factor II, thrombin	Homo sapiens	115-123
10461011-6	1998	Second, in platelet-fibrinogen microaggregates that were preformed in the presence of adrenaline, thrombin/CaCl(2) induced PS exposure and bleb formation of about 35% of the cells.	Epinephrine	86-96	coagulation factor II, thrombin	Homo sapiens	98-106
10461011-8	1998	These results indicate that, in the absence of coagulating plasma, thrombin is a moderate inducer of the procoagulant response of platelets, once integrin alpha(IIb)beta(3)-mediated interactions are stimulated (by adrenaline) and CaCl(2) is present.	Epinephrine	214-224	coagulation factor II, thrombin	Homo sapiens	67-75
9829486-6	1998	In erythrocytes, superoxide dismutase (SOD) activity was determined by the adrenaline method of Misra and Fridovich and catalase was estimated according to Beers and Sizer.	Epinephrine	75-85	superoxide dismutase 1	Homo sapiens	17-37
9829486-6	1998	In erythrocytes, superoxide dismutase (SOD) activity was determined by the adrenaline method of Misra and Fridovich and catalase was estimated according to Beers and Sizer.	Epinephrine	75-85	superoxide dismutase 1	Homo sapiens	39-42
9756528-3	1998	Plasma epinephrine (Epi) and norepinephrine (NE) increased markedly in a dose-dependent manner for up to 120 min after intracerebroventricular or intravenous administration of aFGF (6-667 fmol/rat).	Epinephrine	7-18	fibroblast growth factor 1	Rattus norvegicus	176-180
9799400-2	1998	Epinephrine (Epi) from the serosal side selectively and reversibly inhibited the voltage-activated GCl in toad skin and the short-circuit GCl in frog skin.	Epinephrine	0-11	germ cell-less 2, spermatogenesis associated	Homo sapiens	99-102
9799400-2	1998	Epinephrine (Epi) from the serosal side selectively and reversibly inhibited the voltage-activated GCl in toad skin and the short-circuit GCl in frog skin.	Epinephrine	0-11	germ cell-less 2, spermatogenesis associated	Homo sapiens	138-141
9852340-13	1998	One important action of PACAP in the endocrine system is its role as a potent secretagogue for adrenaline from the adrenal medulla through activation of TH.	Epinephrine	95-105	adenylate cyclase activating polypeptide 1	Homo sapiens	24-29
9753291-3	1998	We studied the effects of insulin (20 U/rat) and epinephrine (25 microg/100 g body wt) injected in vivo on ERK and JNK signaling in skeletal muscle from Sprague-Dawley rats.	Epinephrine	49-60	Eph receptor B1	Rattus norvegicus	107-110
9753291-3	1998	We studied the effects of insulin (20 U/rat) and epinephrine (25 microg/100 g body wt) injected in vivo on ERK and JNK signaling in skeletal muscle from Sprague-Dawley rats.	Epinephrine	49-60	mitogen-activated protein kinase 8	Rattus norvegicus	115-118
9753291-5	1998	In contrast, epinephrine had no effect on ERK phosphorylation or RSK2 activity, but it increased JNK activity by twofold, an effect that was inhibited by the presence of combined alpha and beta blockade.	Epinephrine	13-24	mitogen-activated protein kinase 8	Rattus norvegicus	97-100
9753291-7	1998	The activity and phosphorylation of MAP kinase kinase (MKK)-4, an upstream regulator of JNK, was unchanged by epinephrine.	Epinephrine	110-121	mitogen activated protein kinase kinase 4	Rattus norvegicus	55-61
9753291-8	1998	Incubation of isolated soleus muscles in vitro with epinephrine (10(-5) mol/l) also increased JNK activity by twofold.	Epinephrine	52-63	mitogen-activated protein kinase 8	Rattus norvegicus	94-97
9854632-2	1998	Morphine and adrenaline caused different changes in production of active forms of oxygen (AFA) and antioxidant activity of the enzymes superoxide dismutase and glutathione reductase in neutrophils, monocytes, and lymphocytes in human peripheral blood.	Epinephrine	13-23	AFA	Homo sapiens	90-93
9848093-4	1998	We now report that catecholamines (norepinephrine, epinephrine, and dopamine) increase the vulnerability of cultured hippocampal neurons to A beta toxicity.	Epinephrine	38-49	amyloid beta precursor protein	Homo sapiens	140-146
9781836-5	1998	When the effects of adrenaline and its antagonists on the heat-inducibility of HSP105 were examined, the induction of HSP105 in adrenal gland seemed to be negatively regulated through the alpha-adrenergic receptor.	Epinephrine	20-30	heat shock protein family H (Hsp110) member 1	Rattus norvegicus	79-85
9781836-5	1998	When the effects of adrenaline and its antagonists on the heat-inducibility of HSP105 were examined, the induction of HSP105 in adrenal gland seemed to be negatively regulated through the alpha-adrenergic receptor.	Epinephrine	20-30	heat shock protein family H (Hsp110) member 1	Rattus norvegicus	118-124
9854632-2	1998	Morphine and adrenaline caused different changes in production of active forms of oxygen (AFA) and antioxidant activity of the enzymes superoxide dismutase and glutathione reductase in neutrophils, monocytes, and lymphocytes in human peripheral blood.	Epinephrine	13-23	glutathione-disulfide reductase	Homo sapiens	160-181
9825310-4	1998	The COMT assay was performed with liver homogenates from 60 days old male Wistar rats with adrenaline (AD) as the substrate.	Epinephrine	91-101	catechol-O-methyltransferase	Rattus norvegicus	4-8
9825310-4	1998	The COMT assay was performed with liver homogenates from 60 days old male Wistar rats with adrenaline (AD) as the substrate.	Epinephrine	103-105	catechol-O-methyltransferase	Rattus norvegicus	4-8
9712709-1	1998	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the production of epinephrine from norepinephrine using S-adenosyl-L-methionine as a methyl donor.	Epinephrine	74-85	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
9712709-1	1998	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the production of epinephrine from norepinephrine using S-adenosyl-L-methionine as a methyl donor.	Epinephrine	74-85	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
9756384-11	1998	In isolated white adipocytes of beta3-adrenoceptor knockout mice, the lipolytic responses to (-)epinephrine, to the beta1-, beta2-, beta3-adrenoceptor selective agonists and to CGP 12177 were almost or totally depressed, whereas those to ACTH, forskolin and dibutyryl cyclic AMP were conserved.	Epinephrine	93-107	adrenergic receptor, beta 3	Mus musculus	32-50
9765954-0	1998	Adrenaline induced inhibition of neutrophil PLA2 activity.	Epinephrine	0-10	phospholipase A2 group IB	Homo sapiens	44-48
9689012-1	1998	In the rat cortical collecting duct (CCD), epinephrine inhibits vasopressin (AVP)-dependent water permeability and Na+ reabsorption.	Epinephrine	43-54	arginine vasopressin	Rattus norvegicus	64-75
9667493-1	1998	The oxidation of adrenaline by ferrylmyoglobin, the product formed by the oxidation of myoglobin with H2O2, was examined by absorption, fluorescence, and EPR spectroscopy in terms of the formation of intermediate free radicals and stable molecular products and the binding of adrenaline oxidation products to the apoprotein.	Epinephrine	17-27	myoglobin	Homo sapiens	37-46
9667493-1	1998	The oxidation of adrenaline by ferrylmyoglobin, the product formed by the oxidation of myoglobin with H2O2, was examined by absorption, fluorescence, and EPR spectroscopy in terms of the formation of intermediate free radicals and stable molecular products and the binding of adrenaline oxidation products to the apoprotein.	Epinephrine	276-286	myoglobin	Homo sapiens	37-46
9704017-6	1998	Hormones such as (-)-epinephrine or vasoactive intestinal polypeptide also increased MSP mRNA to 2- to 3-fold.	Epinephrine	17-32	microseminoprotein beta	Homo sapiens	85-88
9783505-6	1998	Thirty minutes after ROSC, renal and adrenal blood flow were significantly lower in the vasopressin group (300 [273-334] and 256 [170-284] ml X min(-1) x 100 g(-1)) (median and 25th and 75th percentile) as compared with the epinephrine group (370 [346-429] and 360 [326-420] ml x min(-1) x 100 g(-1); P &lt; 0.05).	Epinephrine	224-235	vasopressin	Sus scrofa	88-99
9830160-4	1998	The concentration detection limit for epinephrine is about 5.0 x 10(-7) M (90 ng ml-1) with a commercial UV detector.	Epinephrine	38-49	interleukin 17F	Homo sapiens	81-85
9665836-13	1998	The vesicular monoamine transporter 2 (VMAT2) is present in all monoaminergic neurons including epinephrine- and histamine-synthesizing cells.	Epinephrine	96-107	solute carrier family 18 member A2	Homo sapiens	4-37
9665836-13	1998	The vesicular monoamine transporter 2 (VMAT2) is present in all monoaminergic neurons including epinephrine- and histamine-synthesizing cells.	Epinephrine	96-107	solute carrier family 18 member A2	Homo sapiens	39-44
9663564-5	1998	However, co-stimulation with adrenaline, noradrenaline, or the beta-adrenoceptor agonist isoproterenol (isoprenaline) had an additive (TNF-alpha) or synergistic (LPS) effect on IL-6 release.	Epinephrine	29-39	tumor necrosis factor	Rattus norvegicus	135-144
9722189-9	1998	The plasma levels of epinephrine, norepinephrine, and glucagon rose significantly after TRH.	Epinephrine	21-32	thyrotropin releasing hormone	Rattus norvegicus	88-91
9696062-2	1998	Neuropeptide Y (NPY) is found in cell bodies of neurons in the brain and co-localized with noradrenaline (NA) in sympathetic nerves as well as with NA and adrenaline (A) in the adrenal chromaffin cells.	Epinephrine	94-104	neuropeptide Y	Rattus norvegicus	0-14
9696062-2	1998	Neuropeptide Y (NPY) is found in cell bodies of neurons in the brain and co-localized with noradrenaline (NA) in sympathetic nerves as well as with NA and adrenaline (A) in the adrenal chromaffin cells.	Epinephrine	94-104	neuropeptide Y	Rattus norvegicus	16-19
9663564-5	1998	However, co-stimulation with adrenaline, noradrenaline, or the beta-adrenoceptor agonist isoproterenol (isoprenaline) had an additive (TNF-alpha) or synergistic (LPS) effect on IL-6 release.	Epinephrine	29-39	interleukin 6	Rattus norvegicus	177-181
9690052-14	1998	As in human islet response, epinephrine and the alpha 2-agonist clonidine (50 mumol/l) inhibited insulin secretion.	Epinephrine	28-39	insulin	Homo sapiens	97-104
9694567-7	1998	Cholecystokinin- and somatostatin-immunoreactivity is restricted to adrenaline-containing cells.	Epinephrine	68-78	somatostatin 1	Gallus gallus	21-33
9754635-5	1998	Intraperitoneal injections of various doses (0.2-2 mg kg(-1)) of noradrenaline and adrenaline dose-dependently induced hepatic c-fos and c-jun mRNA levels.	Epinephrine	68-78	FBJ osteosarcoma oncogene	Mus musculus	127-132
9754635-5	1998	Intraperitoneal injections of various doses (0.2-2 mg kg(-1)) of noradrenaline and adrenaline dose-dependently induced hepatic c-fos and c-jun mRNA levels.	Epinephrine	68-78	jun proto-oncogene	Mus musculus	137-142
9754635-6	1998	The time-course study showed that there was an increase in c-fos and c-jun mRNA levels within 15 min, which reached a peak at 30 min, and returned to the basal levels 1-2 h after noradrenaline or adrenaline injection (2 mg kg(-1), i.p.).	Epinephrine	182-192	FBJ osteosarcoma oncogene	Mus musculus	59-64
9754635-6	1998	The time-course study showed that there was an increase in c-fos and c-jun mRNA levels within 15 min, which reached a peak at 30 min, and returned to the basal levels 1-2 h after noradrenaline or adrenaline injection (2 mg kg(-1), i.p.).	Epinephrine	182-192	jun proto-oncogene	Mus musculus	69-74
9754635-7	1998	A Western blot assay revealed that c-Jun protein levels were maximally increased at 30 min and 1-2 h in noradrenaline- and adrenaline-treated mice, respectively.	Epinephrine	107-117	jun proto-oncogene	Mus musculus	35-40
9754635-23	1998	The results suggest that noradrenaline elicits the hepatic c-fos and c-jun mRNA responses by stimulating alpha1-adrenergic receptors, whereas in the case of adrenaline, this is elicited by stimulating both alpha1- and beta2-adrenergic receptors in mice.	Epinephrine	28-38	FBJ osteosarcoma oncogene	Mus musculus	59-64
9754635-23	1998	The results suggest that noradrenaline elicits the hepatic c-fos and c-jun mRNA responses by stimulating alpha1-adrenergic receptors, whereas in the case of adrenaline, this is elicited by stimulating both alpha1- and beta2-adrenergic receptors in mice.	Epinephrine	28-38	jun proto-oncogene	Mus musculus	69-74
9645466-3	1998	The alpha2A-adrenoceptor-wild type Gi1alpha fusion protein produced substantially higher maximal stimulation of GTPase activity in response to adrenaline than that containing Gly351 Gi1alpha.	Epinephrine	143-153	adrenoceptor alpha 2A	Homo sapiens	4-24
9603193-1	1998	AP-2 is a vertebrate transcription factor expressed in neural crest cells and their derivative tissues, including the adrenal medulla, where epinephrine is produced.	Epinephrine	141-152	transcription factor AP-2 alpha	Homo sapiens	0-4
9603193-2	1998	AP-2 is shown to stimulate expression of the gene encoding the epinephrine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	63-74	transcription factor AP-2 alpha	Homo sapiens	0-4
9603193-2	1998	AP-2 is shown to stimulate expression of the gene encoding the epinephrine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	63-74	phenylethanolamine N-methyltransferase	Homo sapiens	95-133
9603193-2	1998	AP-2 is shown to stimulate expression of the gene encoding the epinephrine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	63-74	phenylethanolamine N-methyltransferase	Homo sapiens	135-139
9579788-2	1998	Biochemical studies have shown the presence of adrenaline or its biosynthetic enzyme, phenylethanolamine-N-methyltransferase, in the rat and human thalamus.	Epinephrine	47-57	phenylethanolamine-N-methyltransferase	Rattus norvegicus	86-124
9590190-10	1998	In stepwise multiple regression analysis, NPY alone explained blood pressure elevation when analyzed with fluid overload and angiotensin II, renin, noradrenaline, and adrenaline levels.	Epinephrine	151-161	neuropeptide Y	Homo sapiens	42-45
9588422-7	1998	RESULTS: In vitro we found a synergistic increase in epinephrine-induced CD62 expression in the presence of dobutamine.	Epinephrine	53-64	selectin P	Homo sapiens	73-77
9581734-7	1998	Multivariate analysis demonstrated that only a family history of hypertension (chi-square=7.59, p=0.0059) and ET-1 changes during HG (chi-square=4.23, p=0.0398) were predictive of blood pressure response to HG and that epinephrine and norepinephrine were not.	Epinephrine	219-230	endothelin 1	Homo sapiens	110-114
9612241-9	1998	We conclude that PACAP, besides its marked stimulation of insulin secretion, also inhibits insulin sensitivity in mice, the latter possibly explained by increased epinephrine.	Epinephrine	163-174	adenylate cyclase activating polypeptide 1	Mus musculus	17-22
9593563-1	1998	BACKGROUND: This study used monophasic action potential (MAP) to examine the effect of nicorandil, a K+ channel opener, on repolarization abnormalities induced by epinephrine in the LQT1 form of congenital long-QT syndrome in which the KvLQT1 mutation underlies the defect in the channel responsible for the slowly activating component of the delayed rectifier potassium current.	Epinephrine	163-174	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	182-186
9556556-9	1998	The NADPH oxidase activity of TrxR induced by dinitrohalobenzenes generated superoxide, as detected by reaction with epinephrine (the adrenochrome method).	Epinephrine	117-128	peroxiredoxin 5	Homo sapiens	30-34
9620120-1	1998	After injecting the solution extracted from a Primatene Mist inhaler, a patient experienced epinephrine overdose that resulted in an acute myocardial infarction and acute renal failure.	Epinephrine	46-55	cytokine dependent hematopoietic cell linker	Homo sapiens	56-60
9620120-1	1998	After injecting the solution extracted from a Primatene Mist inhaler, a patient experienced epinephrine overdose that resulted in an acute myocardial infarction and acute renal failure.	Epinephrine	92-103	cytokine dependent hematopoietic cell linker	Homo sapiens	56-60
9593563-3	1998	In LQT1 patients, epinephrine infusion prolonged the QT interval and 90% MAP duration (MAPD90) and increased the dispersion of MAPD90.	Epinephrine	18-29	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	3-7
9787764-10	1998	P-selectin is also be expressed on the surface of rabbit platelets activated by other agonists like ADP, A23817 and epinephrine.	Epinephrine	116-127	P-selectin	Oryctolagus cuniculus	0-10
9575832-0	1998	Epinephrine translocates GLUT-4 but inhibits insulin-stimulated glucose transport in rat muscle.	Epinephrine	0-11	solute carrier family 2 member 4	Rattus norvegicus	25-31
9575832-6	1998	Insulin (20 mU/ml) and epinephrine (150 nM) each translocated GLUT-4 to the plasma membrane, and no differences in translocation were observed between insulin and epinephrine (P &gt; 0.05).	Epinephrine	23-34	solute carrier family 2 member 4	Rattus norvegicus	62-68
9575832-7	1998	In addition, epinephrine did not inhibit insulin-stimulated GLUT-4 translocation, and the combined epinephrine and insulin effects on GLUT-4 translocation were not additive.	Epinephrine	99-110	solute carrier family 2 member 4	Rattus norvegicus	134-140
9575832-8	1998	The increase in surface GLUT-4 was associated with increases in muscle cAMP concentrations, but only when epinephrine alone was present.	Epinephrine	106-117	solute carrier family 2 member 4	Rattus norvegicus	24-30
9575832-10	1998	These studies indicate that epinephrine can translocate GLUT-4 while at the same time increasing glucose transport when insulin is absent, or can inhibit glucose transport when insulin is present.	Epinephrine	28-39	solute carrier family 2 member 4	Rattus norvegicus	56-62
9639547-1	1998	We investigated the effects of intracoronary Ca2+ and epinephrine on the intracellular Ca2+ recirculation fraction (RF) and total Ca2+ handling in the left ventricle (LV) of the excised cross-circulated canine heart preparation.	Epinephrine	54-65	carbonic anhydrase 2	Canis lupus familiaris	87-90
9639547-1	1998	We investigated the effects of intracoronary Ca2+ and epinephrine on the intracellular Ca2+ recirculation fraction (RF) and total Ca2+ handling in the left ventricle (LV) of the excised cross-circulated canine heart preparation.	Epinephrine	54-65	carbonic anhydrase 2	Canis lupus familiaris	87-90
9516468-13	1998	Epinephrine treatment for 1 min induced a rapid increase in the phosphorylation of the GRK5 and PKA- mutant betaARs as well as the WT.	Epinephrine	0-11	G protein-coupled receptor kinase 5	Homo sapiens	87-91
9480878-0	1998	Maturation and secretion of rat hepatic lipase is inhibited by alpha1B-adrenergic stimulation through changes in Ca2+ homoeostasis: thapsigargin and EGTA both mimic the effect of adrenaline.	Epinephrine	179-189	lipase C, hepatic type	Rattus norvegicus	32-46
9518674-1	1998	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine (NE) and epinephrine.	Epinephrine	88-99	monoamine oxidase A	Rattus norvegicus	51-70
9536919-2	1998	In order to evaluate factors influencing thermogenesis in obesity, energy expenditure was measured before and during an adrenaline infusion (25 ng min-1 kg-1 ideal body weight for 30 min) in 22 obese females.	Epinephrine	120-130	CD59 molecule (CD59 blood group)	Homo sapiens	147-157
9566851-0	1998	Epinephrine-induced reduction in insulin receptor mRNA level and stability in U-937 human promonocytic cells.	Epinephrine	0-11	insulin receptor	Homo sapiens	33-49
9566851-1	1998	The administration of 10(-5) M epinephrine transiently decreased insulin receptor (IR) mRNA levels in U-937 human promonocytic cells, which reached their minimum value after 24 hours.	Epinephrine	31-42	insulin receptor	Homo sapiens	65-81
9566851-1	1998	The administration of 10(-5) M epinephrine transiently decreased insulin receptor (IR) mRNA levels in U-937 human promonocytic cells, which reached their minimum value after 24 hours.	Epinephrine	31-42	insulin receptor	Homo sapiens	83-85
9566851-2	1998	Such a decrease seems to be due, at least in part, to a reduction in transcript stability, since the IR mRNA half-life was observed to decline from approximately 4h in untreated cells to 3 h in epinephrine-treated cells.	Epinephrine	194-205	insulin receptor	Homo sapiens	101-103
9566851-4	1998	These domains could be targets for a RNA-binding protein induced by treatment with epinephrine producing a destabilization of IR mRNA in U-937 cells.	Epinephrine	83-94	insulin receptor	Homo sapiens	126-128
9536919-9	1998	Adrenaline-induced thermogenesis was predicted by fasting insulin, low basal respiratory quotient and body fat.	Epinephrine	0-10	insulin	Homo sapiens	58-65
9500557-0	1998	Insulin stimulates epinephrine release under euglycemic conditions in humans.	Epinephrine	19-30	insulin	Homo sapiens	0-7
9500557-3	1998	The influence of 90 minutes of euglycemic physiological hyperinsulinemia (60 mU x m(-2) x min(-1); plasma insulin concentration, approximately 700 pmol x L[-1]) on epinephrine kinetics using the 3H-epinephrine tracer method was studied in 12 healthy normotensive, non-obese subjects.	Epinephrine	164-175	insulin	Homo sapiens	61-68
9500557-9	1998	The insulin-induced increase in forearm blood flow ([FBF] by plethysmography, from 3.0 +/- 0.4 to 3.8 +/- 0.6 mL x dL(-1) x min(-1), P = .01) was strongly correlated with the increase in arterial epinephrine (r = .78, P &lt; .01).	Epinephrine	196-207	insulin	Homo sapiens	4-11
9500557-12	1998	However, the combination of insulin and LBNP significantly increased epinephrine release (from 0.37 +/- 0.06 to 0.56 +/- 0.12 nmol x m(-2) x min(-1), P = .03).	Epinephrine	69-80	insulin	Homo sapiens	28-35
9500557-16	1998	Epinephrine release was strongly correlated with the hemodynamic effects of insulin.	Epinephrine	0-11	insulin	Homo sapiens	76-83
9517390-5	1998	We have compared the activation and desensitization of human beta2-adrenoceptor stimulation of adenylyl cyclase induced by salmeterol, adrenaline and salbutamol in a human lung epithelial line, BEAS-2B, expressing beta2-adrenoceptor levels of 40-70 fmol mg(-1), and in human embryonic kidney (HEK) 293 cell lines expressing 2-10 pmol mg(-1).	Epinephrine	135-145	adrenoceptor beta 2	Homo sapiens	61-79
9686145-7	1998	Coinjection of a threshold dose of Ang II or of the NPY agonists together with an ED50 dose of adrenergic agonists such as NA, adrenaline and clonidine counteracted the depressor effect produced by the alpha 2-agonist in the NTS.	Epinephrine	127-137	angiotensinogen	Rattus norvegicus	35-41
9468304-2	1998	The present study demonstrates that a decrease in the level of muscle insulin receptor phosphorylation induced by chronic growth hormone (GH) treatment or acute epinephrine infusion is accompanied by a reduction in the level of IRS-1 phosphorylation and in the association with phosphatidylinositol 3-kinase.	Epinephrine	161-172	insulin receptor	Rattus norvegicus	70-86
9507924-1	1998	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the biosynthesis of epinephrine, has been detected in rat and human spleen with radioenzymatic assays, but the presence of PNMT has not been examined in other lymphoid tissues.	Epinephrine	87-98	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
9507924-1	1998	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the biosynthesis of epinephrine, has been detected in rat and human spleen with radioenzymatic assays, but the presence of PNMT has not been examined in other lymphoid tissues.	Epinephrine	87-98	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
9507924-4	1998	These findings indicate that the PNMT gene is expressed in spleen and thymus and raise the possibility that lymphoid organs synthesize epinephrine as an intrinsic regulator.	Epinephrine	135-146	phenylethanolamine-N-methyltransferase	Rattus norvegicus	33-37
9461228-1	1998	We report that a genetic polymorphism of the alpha2-adrenergic receptor (A2AR) encoded by chromosome 10 is associated with hypertension and an increase in epinephrine-mediated platelet aggregation in humans.	Epinephrine	155-166	adenosine A2a receptor	Homo sapiens	45-71
9461228-1	1998	We report that a genetic polymorphism of the alpha2-adrenergic receptor (A2AR) encoded by chromosome 10 is associated with hypertension and an increase in epinephrine-mediated platelet aggregation in humans.	Epinephrine	155-166	adenosine A2a receptor	Homo sapiens	73-77
9461228-8	1998	Finally, subthreshold concentrations of epinephrine also potentiated thrombin-induced platelet aggregation, and blockade of chloride transport diminished this synergistic action of epinephrine on thrombin-stimulated platelet aggregation.	Epinephrine	40-51	coagulation factor II, thrombin	Homo sapiens	69-77
9461228-8	1998	Finally, subthreshold concentrations of epinephrine also potentiated thrombin-induced platelet aggregation, and blockade of chloride transport diminished this synergistic action of epinephrine on thrombin-stimulated platelet aggregation.	Epinephrine	40-51	coagulation factor II, thrombin	Homo sapiens	196-204
9461228-8	1998	Finally, subthreshold concentrations of epinephrine also potentiated thrombin-induced platelet aggregation, and blockade of chloride transport diminished this synergistic action of epinephrine on thrombin-stimulated platelet aggregation.	Epinephrine	181-192	coagulation factor II, thrombin	Homo sapiens	196-204
9468304-2	1998	The present study demonstrates that a decrease in the level of muscle insulin receptor phosphorylation induced by chronic growth hormone (GH) treatment or acute epinephrine infusion is accompanied by a reduction in the level of IRS-1 phosphorylation and in the association with phosphatidylinositol 3-kinase.	Epinephrine	161-172	insulin receptor substrate 1	Rattus norvegicus	228-233
9458748-8	1998	We conclude that acute alpha 2-blockade in humans 1) prevents epinephrine-induced inhibition of insulin secretion, 2) does not potentiate basal or intravenous- or oral glucose-induced insulin release, 3) enhances thermogenesis, and 4) increases cardiac work.	Epinephrine	62-73	insulin	Homo sapiens	96-103
9453523-9	1998	Patients with vasodepressor syncope had a significant rise in renin (9.03 +/- 4.56 pg/ml versus 52.53 +/- 41.63 pg/ml; p &lt; 0.05) and aldosterone concentration (95.43 +/- 103.03 ng/ml versus 249.57 +/- 191.54 ng/ml; p &lt; 0.05), whereas no change in level of epinephrine (0.12 +/- 0.12 ng/ml versus 0.28 +/- 0.33 ng/ml; p = NS) or norepinephrine (0.60 +/- 0.26 ng/ml versus 0.86 +/- 0.53 ng/ml; p = NS) was detected.	Epinephrine	262-273	renin	Homo sapiens	62-67
9435321-5	1998	In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur.	Epinephrine	105-116	fibrinogen beta chain	Homo sapiens	136-146
9435321-5	1998	In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur.	Epinephrine	105-116	von Willebrand factor	Homo sapiens	197-200
9435321-5	1998	In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur.	Epinephrine	105-116	glycoprotein Ib platelet subunit alpha	Homo sapiens	212-232
9661134-2	1998	In the present study, the relevance of AT1-mediated noradrenaline and adrenaline release in a whole-animal model, which reflects the peripherally sympathetic system (pithed rat), was investigated.	Epinephrine	55-65	angiotensin II receptor, type 1a	Rattus norvegicus	39-42
9833158-1	1998	Angiotensin II is able to modulate both the presynaptic sympathetic system and the adrenal medulla resulting in an enhanced release of noradrenaline and adrenaline.	Epinephrine	138-148	angiotensinogen	Rattus norvegicus	0-14
9831308-7	1998	During hypoglycemia in all subjects the increase in leptin was negatively correlated with the increase in epinephrine (r = 0.60, p = 0.005) and positively with the decrease in free fatty acids (r = 0.71, p = 0.003).	Epinephrine	106-117	leptin	Homo sapiens	52-58
9453333-1	1998	Angiotensin II facilitates epinephrine release during insulin-induced hypoglycemia, and this effect appears to be independent of type 1 angiotensin II (AT1) receptors in man.	Epinephrine	27-38	angiotensinogen	Homo sapiens	0-14
9453333-1	1998	Angiotensin II facilitates epinephrine release during insulin-induced hypoglycemia, and this effect appears to be independent of type 1 angiotensin II (AT1) receptors in man.	Epinephrine	27-38	insulin	Homo sapiens	54-61
9453333-2	1998	In the present study, we hypothesized that the action of angiotensin II on adrenomedullary epinephrine release is mediated by an AT2 receptor-dependent mechanism.	Epinephrine	91-102	angiotensinogen	Rattus norvegicus	57-71
9453333-7	1998	In vehicle-treated rats, the area under the curve for changes in plasma epinephrine concentration [AUC(plasma epinephrine)] during insulin-induced hypoglycemia was 111+/-8 nmolXh/L (+/-SEM).	Epinephrine	72-83	insulin	Homo sapiens	131-138
9453333-7	1998	In vehicle-treated rats, the area under the curve for changes in plasma epinephrine concentration [AUC(plasma epinephrine)] during insulin-induced hypoglycemia was 111+/-8 nmolXh/L (+/-SEM).	Epinephrine	110-121	insulin	Homo sapiens	131-138
9717082-9	1998	Finally, the combination of adrenaline and exogenous IL-10 led to a more pronounced suppression of TNF synthesis after LPS stimulation compared to suppression by IL-10 or adrenaline alone.	Epinephrine	171-181	interleukin 10	Homo sapiens	53-58
9717082-9	1998	Finally, the combination of adrenaline and exogenous IL-10 led to a more pronounced suppression of TNF synthesis after LPS stimulation compared to suppression by IL-10 or adrenaline alone.	Epinephrine	171-181	tumor necrosis factor	Homo sapiens	99-102
9717082-10	1998	The present results suggest the role of protein kinase A activation for adrenaline-induced IL-10 synthesis in human mononuclear cells.	Epinephrine	72-82	interleukin 10	Homo sapiens	91-96
9717082-11	1998	Additionally, based on the kinetic analysis and further experiments described in the literature, endogenous IL-10 could contribute to the adrenaline-induced suppression of TNF synthesis after prolonged incubation.	Epinephrine	138-148	interleukin 10	Homo sapiens	108-113
9717082-11	1998	Additionally, based on the kinetic analysis and further experiments described in the literature, endogenous IL-10 could contribute to the adrenaline-induced suppression of TNF synthesis after prolonged incubation.	Epinephrine	138-148	tumor necrosis factor	Homo sapiens	172-175
9717082-12	1998	These in vitro results could explain the suppression of TNF plasma concentration after parallel infusion of LPS and epinephrine compared to LPS infusion alone as has been demonstrated in a first human study.	Epinephrine	116-127	tumor necrosis factor	Homo sapiens	56-59
9718091-0	1998	Leptin is related to epinephrine levels but not reproductive hormone levels in cycling African-American and Caucasian women.	Epinephrine	21-32	leptin	Homo sapiens	0-6
9718091-7	1998	In addition, in women, and independent of BMI, leptin was negatively correlated with plasma epinephrine levels (r=-0.38, p=0.01).	Epinephrine	92-103	leptin	Homo sapiens	47-53
9440482-7	1998	Concomitant GH and prednisolone administration increased REE (2,068 +/- 85, P +/- .05) and leptin (4.82 +/- 0.93, P +/- .05), had no effect on either epinephrine or norepinephrine, and decreased FT3 (5.0 +/- 0.2, P &lt; .05).	Epinephrine	150-161	growth hormone 1	Homo sapiens	12-14
9440482-5	1998	GH administration decreased plasma epinephrine significantly (mean +/- SE, 34.7 +/- 5.7 ng/L for control v 24.8 +/- 5.8 for GH, P &lt; .05), had no effect on plasma norepinephrine or serum leptin, and increased both free triiodothyronine (FT3) levels (5.7 +/- 0.3 pmol/L for control v 6.7 +/- 0.3 for GH, P &lt; .05) and resting EE ([REE] 1,861 +/- 61 kcal/24 h for control v 1,996 +/- 69 for GH, P &lt; .05).	Epinephrine	35-46	growth hormone 1	Homo sapiens	0-2
9786174-7	1998	Pretreatment with a histamine H1 receptor antagonist blocked both the vasodepressor response to catestatin and the elevation in plasma epinephrine.	Epinephrine	135-146	histamine receptor H 1	Rattus norvegicus	20-41
9787410-4	1998	In vitro incubation of human platelet-rich plasma (PRP) with PAEC inhibited platelet aggregation induced by ADP, collagen and arachidonic acid in a time-dependent manner and partially inhibited adrenalin-induced aggregation.	Epinephrine	194-203	complement component 4 binding protein alpha	Homo sapiens	51-54
9474769-5	1997	Among the systems we studied, the laccase/glucose dehydrogenase sensor is the most sensitive (detection limit: 0.5 nM adrenaline).	Epinephrine	118-128	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	42-63
9435641-0	1997	Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10.	Epinephrine	0-11	interleukin 1 beta	Homo sapiens	39-48
9435641-0	1997	Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10.	Epinephrine	0-11	tumor necrosis factor	Homo sapiens	70-97
9435641-0	1997	Epinephrine inhibits endotoxin-induced IL-1 beta production: roles of tumor necrosis factor-alpha and IL-10.	Epinephrine	0-11	interleukin 10	Homo sapiens	102-107
9415717-1	1997	alpha 2-Adrenergic receptors (alpha 2-ARs) respond to norepinephrine and epinephrine to mediate diverse physiological effects.	Epinephrine	57-68	adrenergic receptor, alpha 2a	Mus musculus	30-41
9429045-6	1997	She required an epinephrine infusion of 0.4 microgram.kg-1.min-1 and prolonged ICU admission.	Epinephrine	16-27	CD59 molecule (CD59 blood group)	Homo sapiens	59-64
9353340-5	1997	Our findings indicate that Ser394 and Ser400 were phosphorylated following phorbol ester-induced activation of protein kinase C, whereas Ser404, Ser408, and Ser410 were phosphorylated upon stimulation of the alpha1BAR with epinephrine.	Epinephrine	223-234	adrenoceptor alpha 1B	Homo sapiens	208-217
9353340-2	1997	In this study, phosphoamino acid analysis of the phosphorylated alpha1BAR revealed that both epinephrine- and phorbol ester-induced phosphorylation predominantly occurs at serine residues of the receptor.	Epinephrine	93-104	adrenoceptor alpha 1B	Homo sapiens	64-73
9357795-0	1997	Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine.	Epinephrine	93-104	solute carrier family 2 member 4	Rattus norvegicus	34-40
9452196-8	1997	The catecholaminergic compound epinephrine, which induces NGF synthesis/secretion, increased the intracellular cyclic AMP content by more than 1000-times at 10 microM.	Epinephrine	31-42	nerve growth factor	Homo sapiens	58-61
9366955-9	1997	In conclusion, the sustained forearm vasodilation during mental stress appears to be partly mediated via beta 2-adrenoceptor stimulation (i.e. by adrenaline), but we obtained no support for a cholinergic vasodilating mechanism.	Epinephrine	146-156	adrenoceptor beta 2	Homo sapiens	105-124
9357795-6	1997	Transcriptional run-on analysis indicated that epinephrine infusion decreased GLUT-4 and increased HKII transcription compared with fasted controls.	Epinephrine	47-58	hexokinase 2	Rattus norvegicus	99-103
9357795-0	1997	Regulation of glucose transporter GLUT-4 and hexokinase II gene transcription by insulin and epinephrine.	Epinephrine	93-104	hexokinase 2	Rattus norvegicus	45-58
9357795-6	1997	Transcriptional run-on analysis indicated that epinephrine infusion decreased GLUT-4 and increased HKII transcription compared with fasted controls.	Epinephrine	47-58	solute carrier family 2 member 4	Rattus norvegicus	78-84
9361934-3	1997	In 19 brain-dead patients whose plasma epinephrine concentrations exceeded 0.4 ng/ml, the mean early insulin release was significantly lower than in controls, while early insulin release was markedly higher in the remaining two patients.	Epinephrine	39-50	insulin	Homo sapiens	101-108
9403317-4	1997	Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine).	Epinephrine	3-14	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	220-226
9403317-4	1997	Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine).	Epinephrine	3-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	237-243
9403317-4	1997	Norepinephrine and epinephrine operate through differential recruitment of alpha 2- and beta-AR subtypes on the basis of their relative affinity for the different subtypes (the relative order of affinity is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine).	Epinephrine	3-14	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	249-255
9350634-12	1997	In response to insulin infusion, catecholamines increased on day 2 (noradrenaline and adrenaline) and day 7 (adrenaline), but not at sea level.	Epinephrine	71-81	insulin	Homo sapiens	15-22
9350634-12	1997	In response to insulin infusion, catecholamines increased on day 2 (noradrenaline and adrenaline) and day 7 (adrenaline), but not at sea level.	Epinephrine	86-96	insulin	Homo sapiens	15-22
9380436-3	1997	The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) catalyze the rate-limiting step in the catecholamine pathway and production of epinephrine, respectively.	Epinephrine	167-178	phenylethanolamine-N-methyltransferase	Rattus norvegicus	42-80
9380436-3	1997	The enzymes tyrosine hydroxylase (TH) and phenylethanolamine N-methyltransferase (PNMT) catalyze the rate-limiting step in the catecholamine pathway and production of epinephrine, respectively.	Epinephrine	167-178	phenylethanolamine-N-methyltransferase	Rattus norvegicus	82-86
9326357-0	1997	Adrenaline inhibits depolarization-induced increases in capacitance the presence of elevated [Ca2+]i in insulin secreting cells.	Epinephrine	0-10	insulin	Homo sapiens	104-111
9352569-1	1997	Catechol-O-methyltransferase catalyses the O-methylation of biologically active or toxic catechols and is a major component of the metabolism of drugs and neurotransmitters such as L-dopa, noradrenaline, adrenaline, and dopamine.	Epinephrine	192-202	catechol-O-methyltransferase	Homo sapiens	0-28
9299533-2	1997	Using this EIA system, we examined the effect of dopaminergic transmitters such as dopamine and epinephrine on BDNF synthesis in mouse astrocytes in culture.	Epinephrine	96-107	brain derived neurotrophic factor	Mus musculus	111-115
9295336-5	1997	The coupling efficiencies for betaAR agonist activation of adenylyl cyclase relative to epinephrine (100%) were 42% for fenoterol, 4.9% for albuterol, 2.5% for dobutamine, and 1.1% for ephedrine.	Epinephrine	88-99	adrenoceptor beta 2	Homo sapiens	30-36
9295336-6	1997	At concentrations of these agonists yielding &gt;90% receptor occupancy, the rate and extent (0-30 min) of agonist-induced desensitization of betaAR activation of adenylyl cyclase followed the same order as coupling efficiency, i.e. epinephrine &gt;/= fenoterol &gt; albuterol &gt; dobutamine &gt; ephedrine.	Epinephrine	233-244	adrenoceptor beta 2	Homo sapiens	142-148
9295336-9	1997	The two strongest agonists, epinephrine and fenoterol, provoked 11-13-fold increases in the level of betaAR phosphorylation after just 1 min, whereas the weak agonists dobutamine and ephedrine caused only 3-4-fold increases, similar to levels induced by cAMP-dependent protein kinase activation with forskolin.	Epinephrine	28-39	adrenoceptor beta 2	Homo sapiens	101-107
9295336-10	1997	With longer treatment times, the level of betaAR phosphorylation declined with strong agonists, but it progressively increased with the weaker partial agonists, such that after 30 min the -fold elevation with epinephrine (6.2 +/- 0.82) was not appreciably different from ephedrine (5.0 +/- 0.96) and significantly less than that caused by albuterol (10.4 +/- 1.7).	Epinephrine	209-220	adrenoceptor beta 2	Homo sapiens	42-48
9316473-14	1997	Bombesin-like peptides appear to induce Ca(2+)-phospholipid-dependent signal-response transduction, as is indirectly suggested by potentiating interactions with DBcAMP or epinephrine.	Epinephrine	171-182	gastrin releasing peptide	Homo sapiens	0-8
9316430-4	1997	The purpose of this study was to determine the effect of epinephrine on GLUT-4 phosphorylation, and reevaluate the effect of beta-adrenergic stimulation on insulin-activated glucose transport, in skeletal muscle.	Epinephrine	57-68	solute carrier family 2 member 4	Rattus norvegicus	72-78
9313925-2	1997	In this study we have compared the abilities of the enantiomers of the structural isomers of the phenolamines, octopamine and synephrine, and the catecholamines, noradrenaline and adrenaline, to couple selectively a human cloned alpha 2A-adrenoceptor, stably expressed in a Chinese hamster ovary (CHO) cell line, to G-protein linked second messenger pathways mediating an increase and a decrease in cyclic AMP production.	Epinephrine	165-175	adrenoceptor alpha 2A	Homo sapiens	229-250
9316430-5	1997	We found that 1 microM epinephrine, which raised adenosine 3",5"-cyclic monophosphate approximately ninefold, resulted in GLUT-4 phosphorylation in rat skeletal muscle but had no inhibitory effect on insulin-stimulated 3-O-methyl-D-glucose (3-MG) transport.	Epinephrine	23-34	solute carrier family 2 member 4	Rattus norvegicus	122-128
9300318-12	1997	These results suggest that treatment of patients with primary hypertension with the beta 1-adrenoceptor blocker atenolol inhibits the adrenomedullary secretion of epinephrine, but it does not affect the biochemical indices of sympathoneural activity.	Epinephrine	163-174	adrenoceptor beta 1	Homo sapiens	84-103
9287058-9	1997	When portohepatic normoglycemia was maintained during POR(UPS), a 67% suppression in the epinephrine response versus that during PER was observed (P &lt; 0.001).	Epinephrine	89-100	cytochrome p450 oxidoreductase	Rattus norvegicus	54-57
9413829-5	1997	The results showed that the enhanced activity of tryptophan 2,3-dioxygenase caused by nicotinic acid was partly restored by adrenaline following adrenalectomy but not by corticosterone supplementation.	Epinephrine	124-134	tryptophan 2,3-dioxygenase	Rattus norvegicus	49-75
9413829-7	1997	The conclusion that adrenaline participates in the regulation of tryptophan 2,3-dioxygenase should promote further study to determine whether adrenaline is a general modulator of this enzyme.	Epinephrine	20-30	tryptophan 2,3-dioxygenase	Rattus norvegicus	65-91
9413829-7	1997	The conclusion that adrenaline participates in the regulation of tryptophan 2,3-dioxygenase should promote further study to determine whether adrenaline is a general modulator of this enzyme.	Epinephrine	142-152	tryptophan 2,3-dioxygenase	Rattus norvegicus	65-91
9250445-1	1997	OBJECTIVE: To test the hypothesis that because of sustained glycemic actions, bedtime administration of the glucagon-releasing amino acid alanine or the epinephrine-simulating beta2-adrenergic agonist terbutaline more effectively prevents nocturnal hypoglycemia than a conventional bedtime snack, we studied 15 patients with IDDM.	Epinephrine	153-164	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	176-181
9277398-9	1997	We conclude that insulin is secreted from isolated islets and that exposure to LPS acutely increases islet-derived TNF activity, whereas epinephrine modifies TNF and insulin secretion of rat pancreatic islets.	Epinephrine	137-148	tumor necrosis factor-like	Rattus norvegicus	158-161
9245486-0	1997	The inhibitory effect of rolipram on TNF-alpha production in mouse blood ex vivo is dependent upon the release of corticosterone and adrenaline.	Epinephrine	133-143	tumor necrosis factor	Mus musculus	37-46
9245486-5	1997	These data suggest the release of both corticosterone and adrenaline contribute to the ability of rolipram to inhibit TNF-alpha production in mouse blood ex vivo.	Epinephrine	58-68	tumor necrosis factor	Mus musculus	118-127
9717082-0	1998	Adrenaline enhances LPS-induced IL-10 synthesis: evidence for protein kinase A-mediated pathway.	Epinephrine	0-10	interleukin 10	Homo sapiens	32-37
9717082-4	1998	In this in vitro model adrenaline enhanced the LPS-induced synthesis of IL-10 with parallel suppression of TNF synthesis.	Epinephrine	23-33	interleukin 10	Homo sapiens	72-77
9717082-4	1998	In this in vitro model adrenaline enhanced the LPS-induced synthesis of IL-10 with parallel suppression of TNF synthesis.	Epinephrine	23-33	tumor necrosis factor	Homo sapiens	107-110
9717082-7	1998	Simultaneous addition of adrenaline and (Rp)-cAMPS led to a reversal of IL-10 synthesis to values induced by LPS stimulation alone.	Epinephrine	25-35	interleukin 10	Homo sapiens	72-77
9717082-9	1998	Finally, the combination of adrenaline and exogenous IL-10 led to a more pronounced suppression of TNF synthesis after LPS stimulation compared to suppression by IL-10 or adrenaline alone.	Epinephrine	28-38	tumor necrosis factor	Homo sapiens	99-102
9331967-1	1997	The catalytic activity of superoxide dismutase (SOD) and its conjugates with catalase and polymer peroxidase (p-peroxidase) obtained during covalent binding of enzymes with aldehyde dextrans was indirectly characterized by inhibition of adrenaline autoxidation in 0.1 M bicarbonate buffer, pH 10.2, and in microemulsion of 0.1 M aerosol OT (AOT) and Triton X-45 in octane containing 15% aqueous phase.	Epinephrine	237-247	superoxide dismutase 1	Homo sapiens	26-46
9253353-0	1997	Influence of circulating epinephrine and norepinephrine on insulin-like growth factor binding protein-1 in humans.	Epinephrine	25-36	insulin like growth factor binding protein 1	Homo sapiens	59-103
9253353-1	1997	The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations.	Epinephrine	77-88	insulin like growth factor binding protein 1	Homo sapiens	132-176
9253353-1	1997	The aim of the present study was to investigate the influence of circulating epinephrine (Epi) and norepinephrine (Norepi) on serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations.	Epinephrine	77-88	insulin like growth factor binding protein 1	Homo sapiens	178-185
9487014-2	1997	Enzymes in this biosynthetic pathway, as well as those involved in the synthesis of the essential co-factor (6R)L-erythro-5,6,7,8-tetrahydrobiopterin (6-BH4) are expressed in keratinocytes producing the important hormones norepinephrine and epinephrine, which control a high beta 2-adrenoceptor density on undifferentiated/proliferating keratinocytes and the expression of alpha 1-adrenoceptors on melanocytes.	Epinephrine	225-236	adrenoceptor beta 2	Homo sapiens	275-294
9268194-5	1997	Stimulation of platelets with thrombin, ADP or epinephrine causes a partial translocation of dynein from the soluble fraction to the particulate fraction with thrombin being the most efficient agent at promoting this shift.	Epinephrine	47-58	coagulation factor II, thrombin	Homo sapiens	159-167
9296350-3	1997	Simulations of the two models revealed that the two forms of activation are distinguishable by the effect of Gs levels on epinephrine-stimulated EC50 values for cyclase activation; specifically, the shuttle model predicts an increased potency of epinephrine stimulation as levels of Gs alpha increase.	Epinephrine	246-257	GNAS complex locus	Homo sapiens	283-291
9296350-5	1997	Expression of Gs alpha was strongly correlated to the appearance of GTP shifts in the competitive binding of epinephrine with [125I]iodocyanopindolol to the beta-adrenergic receptors and epinephrine-stimulated adenylyl cyclase activity.	Epinephrine	109-120	GNAS complex locus	Homo sapiens	14-22
9296350-5	1997	Expression of Gs alpha was strongly correlated to the appearance of GTP shifts in the competitive binding of epinephrine with [125I]iodocyanopindolol to the beta-adrenergic receptors and epinephrine-stimulated adenylyl cyclase activity.	Epinephrine	187-198	GNAS complex locus	Homo sapiens	14-22
9296350-6	1997	Most importantly, high expression of Gs alpha resulted in lower EC50 values for epinephrine and prostaglandin E1 stimulation of adenylyl cyclase activity.	Epinephrine	80-91	GNAS complex locus	Homo sapiens	37-45
9288945-6	1997	However, maximal cAMP accumulation was significantly reduced in response to various beta3-adrenergic agonists, including endogenous catecholamines, (-)-epinephrine and (-)-norepinephrine, the non-selective agonist (-)-isoproterenol, and the beta3-adrenergic selective agonist CGP 12177A.	Epinephrine	148-163	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	84-89
9220972-4	1997	Wild-type alpha2AAR underwent 31% +/- 3% downregulation after 24 h of exposure to 100 microM epinephrine.	Epinephrine	93-104	alpha-2A adrenergic receptor	Cricetulus griseus	10-19
9296350-3	1997	Simulations of the two models revealed that the two forms of activation are distinguishable by the effect of Gs levels on epinephrine-stimulated EC50 values for cyclase activation; specifically, the shuttle model predicts an increased potency of epinephrine stimulation as levels of Gs alpha increase.	Epinephrine	122-133	GNAS complex locus	Homo sapiens	283-291
9331967-1	1997	The catalytic activity of superoxide dismutase (SOD) and its conjugates with catalase and polymer peroxidase (p-peroxidase) obtained during covalent binding of enzymes with aldehyde dextrans was indirectly characterized by inhibition of adrenaline autoxidation in 0.1 M bicarbonate buffer, pH 10.2, and in microemulsion of 0.1 M aerosol OT (AOT) and Triton X-45 in octane containing 15% aqueous phase.	Epinephrine	237-247	superoxide dismutase 1	Homo sapiens	48-51
9331967-1	1997	The catalytic activity of superoxide dismutase (SOD) and its conjugates with catalase and polymer peroxidase (p-peroxidase) obtained during covalent binding of enzymes with aldehyde dextrans was indirectly characterized by inhibition of adrenaline autoxidation in 0.1 M bicarbonate buffer, pH 10.2, and in microemulsion of 0.1 M aerosol OT (AOT) and Triton X-45 in octane containing 15% aqueous phase.	Epinephrine	237-247	catalase	Homo sapiens	77-85
9197308-1	1997	BACKGROUND: Intravenous administration of vasopressin during cardiopulmonary resuscitation (CPR) has been shown to be more effective than optimal doses of epinephrine.	Epinephrine	155-166	vasopressin	Sus scrofa	42-53
9223197-6	1997	RESULTS: The CPT 1 given before anesthetic administration resulted in an increase in heart rate, mean arterial pressure, cardiac index, and plasma concentrations of norepinephrine and epinephrine.	Epinephrine	168-179	carnitine palmitoyltransferase 1A	Homo sapiens	13-18
9237550-1	1997	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A metabolite of norepinephrine and epinephrine.	Epinephrine	88-99	monoamine oxidase A	Rattus norvegicus	51-70
9221898-1	1997	The ability of sodium butyrate and dexamethasone to promote adrenergic differentiation in PC12 cells was examined using the gene encoding the epinephrine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), as a marker.	Epinephrine	142-153	phenylethanolamine-N-methyltransferase	Rattus norvegicus	175-213
9200653-3	1997	Responses of adrenaline improved more in DAN- patients (from 1.17 +/- 0.12 to 2.4 +/- 0.22 nmol/l) than in DAN+PH- (from 0.75 +/- 0.25 to 1.56 +/- 0.23 nmol/l) and DAN+PH+ patients (from 0.80 +/- 0.24 to 1.15 +/- 0.27 nmol/l, P &lt; 0.05) but remained lower than in nondiabetic subjects (4.9 +/- 0.37 nmol/l, P &lt; 0.05), whereas glycemic thresholds normalized only in DAN-, not DAN+.	Epinephrine	13-23	NBL1, DAN family BMP antagonist	Homo sapiens	41-44
9200653-7	1997	We conclude that DAN, long IDDM duration per se, and antecedent recent hypoglycemia contribute to different extents to impaired adrenaline responses and hypoglycemia unawareness.	Epinephrine	128-138	NBL1, DAN family BMP antagonist	Homo sapiens	17-20
9187779-2	1997	Intrathecal fentanyl (ITF) provides effective labour analgesia but its effect on maternal epinephrine (Epi) and norepinephrine (NE) concentrations is not known.	Epinephrine	90-101	trefoil factor 3	Homo sapiens	22-25
9187779-11	1997	Intrathecal Fentanyl (ITF) is also capable of reducing maternal plasma epinephrine concentration, thus avoiding the possibly deleterious side effects of excess amounts of this catecholamine during labour.	Epinephrine	71-82	trefoil factor 3	Homo sapiens	22-25
9180633-4	1997	The increased arterial plasma epinephrine levels appeared to be due to a higher total body epinephrine spillover rate in the hypertensive subjects (0.23 +/- 0.02 nmol.min-1.m-2) than the normotensive subjects (0.18 +/- 0.01) (P &lt; .05) and not to a decreased plasma clearance of epinephrine.	Epinephrine	30-41	CD59 molecule (CD59 blood group)	Homo sapiens	167-172
9207394-3	1997	Preincubation with thrombopoietin significantly enhanced platelet aggregation stimulated by ADP, collagen, or epinephrine in the MPD group as well as the control group.	Epinephrine	110-121	thrombopoietin	Homo sapiens	19-33
9207394-4	1997	However, aggregation induced by 3 micro ADP or 16 microM epinephrine showed significantly less augmentation by thrombopoietin in the MPD group than in the control group.	Epinephrine	57-68	thrombopoietin	Homo sapiens	111-125
9207394-5	1997	Thrombopoietin significantly shortened the lag time between the addition of 3 microM ADP or 16 microM epinephrine and initiation of secondary aggregation and the lag time between addition of 2 microg/ml collagen and initiation of aggregation in both groups.	Epinephrine	102-113	thrombopoietin	Homo sapiens	0-14
9165054-3	1997	Adrenaline administered to anesthetized mice stimulated both the endocrine secretion of EGF from submandibular salivary glands and the degradation of glycogen in the liver.	Epinephrine	0-10	epidermal growth factor	Mus musculus	88-91
9165054-7	1997	EGF, added to isolated hepatocytes, reduced the glycogenolytic effect of adrenaline (the maximal effect but not the ED50).	Epinephrine	73-83	epidermal growth factor	Mus musculus	0-3
9165054-13	1997	These results demonstrate that the effect of EGF on the glycogenolytic action of adrenaline involves interference with the generation of the cAMP signal.	Epinephrine	81-91	epidermal growth factor	Mus musculus	45-48
9186311-12	1997	This decrease in muscle glycogen content may trigger an enhancement of insulin-induced glucose uptake similar to that observed during muscle contraction or epinephrine treatment.	Epinephrine	156-167	insulin	Homo sapiens	71-78
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Epinephrine	188-199	tyrosine hydroxylase	Bos taurus	50-52
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Epinephrine	188-199	phenylethanolamine N-methyltransferase	Bos taurus	63-67
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Epinephrine	204-215	tyrosine hydroxylase	Bos taurus	50-52
9166715-3	1997	In the presence of 40 microM H-89, mRNA levels of TH, DBH, and PNMT were reduced to 17 +/- 8, 19 +/- 8, and 14 +/- 2% of the untreated control, respectively, in 24 h, and intracellular norepinephrine and epinephrine levels were decreased to 20 and 34%, respectively, in 72 h. At 20 microM, although the basal enzyme gene expression levels were little affected, their induction by forskolin was abolished and norepinephrine and epinephrine levels fell to 55 and 74%.	Epinephrine	204-215	phenylethanolamine N-methyltransferase	Bos taurus	63-67
9169777-0	1997	Lipopolysaccharide-induced interleukin 8 production by human whole blood is enhanced by epinephrine and inhibited by hydrocortisone.	Epinephrine	88-99	C-X-C motif chemokine ligand 8	Homo sapiens	27-40
9169777-2	1997	Epinephrine caused a dose-dependent increase in LPS-induced IL-8 production, which was mediated exclusively via beta-adrenergic receptors, as reflected by the facts that beta (but not alpha) receptor blockade reversed the epinephrine effect and beta (but not alpha) receptor stimulation reproduced the epinephrine effect.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9169777-2	1997	Epinephrine caused a dose-dependent increase in LPS-induced IL-8 production, which was mediated exclusively via beta-adrenergic receptors, as reflected by the facts that beta (but not alpha) receptor blockade reversed the epinephrine effect and beta (but not alpha) receptor stimulation reproduced the epinephrine effect.	Epinephrine	222-233	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9169777-2	1997	Epinephrine caused a dose-dependent increase in LPS-induced IL-8 production, which was mediated exclusively via beta-adrenergic receptors, as reflected by the facts that beta (but not alpha) receptor blockade reversed the epinephrine effect and beta (but not alpha) receptor stimulation reproduced the epinephrine effect.	Epinephrine	302-313	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
9169777-4	1997	Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10.	Epinephrine	0-11	interleukin 10	Homo sapiens	36-41
9169777-4	1997	Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
9169777-4	1997	Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	185-189
9169777-4	1997	Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10.	Epinephrine	0-11	interleukin 10	Homo sapiens	239-244
9169777-4	1997	Epinephrine-induced upregulation of IL-10 production masked an even more pronounced stimulating effect of this hormone on IL-8 synthesis, as indicated by the finding that the extent of IL-8 upregulation was greater in the presence of anti-IL-10 than in the absence of anti-IL-10.	Epinephrine	0-11	interleukin 10	Homo sapiens	239-244
9169777-5	1997	Hydrocortisone dose-dependently inhibited LPS-induced IL-8 production and reversed epinephrine-induced enhancement of IL-8 production.	Epinephrine	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	118-122
9169777-6	1997	Epinephrine and hydrocortisone have opposite effects on IL-8 production, which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	56-60
9169777-6	1997	Epinephrine and hydrocortisone have opposite effects on IL-8 production, which may be relevant for the understanding of endogenous and therapeutic stress hormone influences on IL-8 mediated inflammation.	Epinephrine	0-11	C-X-C motif chemokine ligand 8	Homo sapiens	176-180
9205542-4	1997	RESULTS: Insulin treatment significantly increased Emax (34 +/- 3 vs. 17 +/- 3 mmHg/mm, saline control), and shortened Tau (9 +/- 3 ms) compared to saline control (42 +/- 5 ms), epinephrine (20 +/- 4 ms) and glucagon (35 +/- 8 ms).	Epinephrine	178-189	insulin	Canis lupus familiaris	9-16
9164836-3	1997	The oxidation product of adrenaline, adrenochrome, is less active as a substrate for GST M2-2, and more efficiently conjugated by GST M1-1.	Epinephrine	25-35	glutathione S-transferase mu 2	Homo sapiens	85-93
9168979-3	1997	This antibody inhibited high shear-induced platelet aggregation and blocked adhesion of ADP plus epinephrine-stimulated platelets to vWf, indicating that it interferes with the interaction with alpha IIb beta 3.	Epinephrine	97-108	von Willebrand factor	Homo sapiens	133-136
9205950-6	1997	Furthermore, both beta 1 and beta 2-adrenoceptors can mediate experimental arrhythmias in human cardiac preparations elicited by noradrenaline and adrenaline.	Epinephrine	132-142	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	18-24
9205950-6	1997	Furthermore, both beta 1 and beta 2-adrenoceptors can mediate experimental arrhythmias in human cardiac preparations elicited by noradrenaline and adrenaline.	Epinephrine	132-142	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	29-35
9241755-2	1997	In vivo, epinephrine and the vasopressin analog DDAVP increase vWf plasma levels, although they are thought not to induce vWf release from endothelial cells in vitro.	Epinephrine	9-20	von Willebrand factor	Homo sapiens	63-66
9241755-7	1997	Epinephrine (together with IBMX) caused a small, dose-dependent increase in vWf release, maximal at 10(-6) M (+50%), and also potentiated the response to thrombin.	Epinephrine	0-11	von Willebrand factor	Homo sapiens	76-79
9241755-7	1997	Epinephrine (together with IBMX) caused a small, dose-dependent increase in vWf release, maximal at 10(-6) M (+50%), and also potentiated the response to thrombin.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	154-162
9241755-11	1997	We found a close correlation between cellular cAMP content and vWf release after stimulation with epinephrine and forskolin.	Epinephrine	98-109	von Willebrand factor	Homo sapiens	63-66
9241755-12	1997	These results demonstrate that cAMP-dependent signaling events are involved in the control of exocytosis from endothelial cells (an effect not mediated by an increase in [Ca2+]i) and provide an explanation for epinephrine-induced vWf release.	Epinephrine	210-221	von Willebrand factor	Homo sapiens	230-233
9133549-3	1997	In DAN- patients, maximal responses of adrenaline to hypoglycemia were reduced (2.44 +/- 0.58 nmol/l vs. 4.9 +/- 0.54 nmol/l in nondiabetic patients) (P &lt; 0.05).	Epinephrine	39-49	NBL1, DAN family BMP antagonist	Homo sapiens	3-6
9133549-4	1997	In DAN+, adrenaline responses initiated at a lower plasma glucose and were lower than in DAN- (DAN+PH-, 1.06 +/- 0.38 nmol/l; DAN+PH+, 0.84 +/- 0.27 nmol/l; P &lt; 0.001, but NS between PH- and PH+).	Epinephrine	9-19	NBL1, DAN family BMP antagonist	Homo sapiens	3-6
9133549-5	1997	In response to exercise, adrenaline increased less in DAN- (0.89 +/- 0.11 nmol/l) patients than in nondiabetic subjects (1.19 +/- 0.14 nmol/l; NS) and only to 0.36 +/- 0.07 nmol/l in DAN+PH- and 0.23 +/- 0.09 nmol/l in DAN+PH+ (P &lt; 0.001 vs. DAN- and nondiabetic subjects).	Epinephrine	25-35	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
9133549-5	1997	In response to exercise, adrenaline increased less in DAN- (0.89 +/- 0.11 nmol/l) patients than in nondiabetic subjects (1.19 +/- 0.14 nmol/l; NS) and only to 0.36 +/- 0.07 nmol/l in DAN+PH- and 0.23 +/- 0.09 nmol/l in DAN+PH+ (P &lt; 0.001 vs. DAN- and nondiabetic subjects).	Epinephrine	25-35	NBL1, DAN family BMP antagonist	Homo sapiens	183-186
9133549-5	1997	In response to exercise, adrenaline increased less in DAN- (0.89 +/- 0.11 nmol/l) patients than in nondiabetic subjects (1.19 +/- 0.14 nmol/l; NS) and only to 0.36 +/- 0.07 nmol/l in DAN+PH- and 0.23 +/- 0.09 nmol/l in DAN+PH+ (P &lt; 0.001 vs. DAN- and nondiabetic subjects).	Epinephrine	25-35	NBL1, DAN family BMP antagonist	Homo sapiens	183-186
9133549-5	1997	In response to exercise, adrenaline increased less in DAN- (0.89 +/- 0.11 nmol/l) patients than in nondiabetic subjects (1.19 +/- 0.14 nmol/l; NS) and only to 0.36 +/- 0.07 nmol/l in DAN+PH- and 0.23 +/- 0.09 nmol/l in DAN+PH+ (P &lt; 0.001 vs. DAN- and nondiabetic subjects).	Epinephrine	25-35	NBL1, DAN family BMP antagonist	Homo sapiens	183-186
9133549-7	1997	Thus, DAN (both PH+ and PH-) contributes to reduced responses of adrenaline to hypoglycemia independently of recent antecedent hypoglycemia.	Epinephrine	65-75	NBL1, DAN family BMP antagonist	Homo sapiens	6-9
9149678-11	1997	In the Cox model, familial pheochromocytoma and a low ratio of plasma epinephrine to total catecholamines were independently associated with recurrence.	Epinephrine	70-81	cytochrome c oxidase subunit 8A	Homo sapiens	7-10
9146854-3	1997	RESULTS: In the presence of fibrinogen (300 micrograms ml-1) both collagen (5 micrograms ml-1) and adrenaline (16 microM) stimulated the aggregation of washed platelets.	Epinephrine	99-109	fibrinogen beta chain	Homo sapiens	28-38
9219083-8	1997	PAF levels were different in patients requiring postoperative epinephrine (2124 +/- 700 pg/mL) or dopamine (667 +/- 266 pg/mL) (P = 0.0042).	Epinephrine	62-73	PCNA clamp associated factor	Homo sapiens	0-3
10072943-4	1997	RESULTS: Cyc-A, similar to or slightly stronger than amiodarone (Ami), decreased incidences of atrial fibrillation elicited by CaCl2-acetylcholine in mice and increased doses of aconitine, ouabain, or adrenaline to elicit atrial fibrillation in isolated guinea pig atria.	Epinephrine	201-211	cyclin A2	Mus musculus	9-14
10072943-6	1997	In isolated left atria, Cyc-A 0.3-30 mumol.L-1 inhibited the abnormal rhythmic activity elicited by adrenaline, prolonged action potential duration (APD) and effective refractory period, and reduced excitability.	Epinephrine	100-110	cyclin A2	Mus musculus	24-29
9099753-9	1997	Stimulation of platelets by several agonists such as collagen, ADP, epinephrine, and calcium ionophore A23187 induced RAFTK phosphorylation.	Epinephrine	68-79	protein tyrosine kinase 2 beta	Homo sapiens	118-123
9092590-10	1997	L-Epi and DA inhibit fET-mediated [3H]-L-NE uptake more potently than they inhibit [3H]-L-NE uptake by human NET (hNET), whereas L-NE exhibits equivalent potency between the two carriers.	Epinephrine	0-5	solute carrier family 6 member 2	Homo sapiens	109-112
9092590-10	1997	L-Epi and DA inhibit fET-mediated [3H]-L-NE uptake more potently than they inhibit [3H]-L-NE uptake by human NET (hNET), whereas L-NE exhibits equivalent potency between the two carriers.	Epinephrine	0-5	solute carrier family 6 member 2	Homo sapiens	114-118
9142876-6	1997	Despite equivalent peripheral insulin levels and hypoglycemia, incremental area under the curve responses for epinephrine, glucagon and cortisol were increased during head insulin infusion (P &lt; 0.05).	Epinephrine	110-121	insulin	Canis lupus familiaris	172-179
9131641-2	1997	Stress enhances excretion of adrenaline, which is deaminated by monoamine oxidase and methylamine is formed.	Epinephrine	29-39	monoamine oxidase A	Homo sapiens	64-81
9131641-6	1997	Methylamine was confirmed to be a product of adrenaline catalyzed by type A monoamine oxidase (MAO-A).	Epinephrine	45-55	monoamine oxidase A	Homo sapiens	76-93
9131641-6	1997	Methylamine was confirmed to be a product of adrenaline catalyzed by type A monoamine oxidase (MAO-A).	Epinephrine	45-55	monoamine oxidase A	Homo sapiens	95-100
9228469-5	1997	The concentration of CgA in the patients with non-metastatic pheochromocytoma was significantly correlated with that of plasma norepinephrine (P &lt; 0.005, r = 0.68) and urinary norepinephrine (P &lt; 0.05, r = 0.65), but not with that of epinephrine.	Epinephrine	130-141	chromogranin A	Homo sapiens	21-24
9089644-0	1997	Tissue-specific modulation of insulin receptor mRNA levels in adrenaline-treated rats.	Epinephrine	62-72	insulin receptor	Rattus norvegicus	30-46
9147034-5	1997	A-1c also is more potent and longer acting than A-1 in protecting mice from collagen+epinephrine-induced thromboembolic death.	Epinephrine	85-96	B cell leukemia/lymphoma 2 related protein A1c	Mus musculus	0-4
9147034-5	1997	A-1c also is more potent and longer acting than A-1 in protecting mice from collagen+epinephrine-induced thromboembolic death.	Epinephrine	85-96	brain protein 1	Mus musculus	0-3
9119969-3	1997	Infusion of adrenaline, but not noradrenaline, significantly decreased beta2- and alpha1-adrenoceptor numbers on NK cells.	Epinephrine	12-22	adrenoceptor beta 2	Homo sapiens	71-101
9089644-1	1997	Insulin receptor (IR) gene expression at the mRNA level was investigated in liver, hindlimb skeletal muscle, and epididymal adipose tissue of rats exposed to prolonged in vivo administration of adrenaline in relation to control rats.	Epinephrine	194-204	insulin receptor	Rattus norvegicus	0-16
9089644-1	1997	Insulin receptor (IR) gene expression at the mRNA level was investigated in liver, hindlimb skeletal muscle, and epididymal adipose tissue of rats exposed to prolonged in vivo administration of adrenaline in relation to control rats.	Epinephrine	194-204	insulin receptor	Rattus norvegicus	18-20
9091588-3	1997	Epinephrine enhanced LPS-induced activation of fibrinolysis (plasma levels of tissue-type plasminogen activator and plasmin-alpha2-antiplasmin complexes; P &lt;0.05), but did not influence inhibition of fibrinolysis (plasminogen activator inhibitor type I).	Epinephrine	0-11	plasminogen activator, tissue type	Homo sapiens	78-111
9062902-2	1997	We investigated the kinetics and potency of adrenaline-mediated inhibition of oxidant generation in FMLP- and zymosan-stimulated PMNLs.	Epinephrine	44-54	formyl peptide receptor 1	Homo sapiens	100-104
9297781-7	1997	A noticeable signal was also present in the medullary area, especially for GC-A mRNA, in adrenaline-containing chromaffin cells.	Epinephrine	89-99	grancalcin	Rattus norvegicus	75-79
9167626-4	1997	After 21 days, concentrations of norepinephrine and epinephrine were significantly increased in the group treated with nerve growth factor compared with those in the control group (211% norepinephrine and 322% epinephrine).	Epinephrine	36-47	nerve growth factor	Rattus norvegicus	119-138
9167626-4	1997	After 21 days, concentrations of norepinephrine and epinephrine were significantly increased in the group treated with nerve growth factor compared with those in the control group (211% norepinephrine and 322% epinephrine).	Epinephrine	52-63	nerve growth factor	Rattus norvegicus	119-138
9083230-13	1997	The decrease in pHi and the increase in the lactate/pyruvate ratio in the epinephrine group was transient, since it returned to normal within 24 h. CONCLUSIONS: Considering the global hemodynamic effects, epinephrine is as effective as norepinephrine-dobutamine.	Epinephrine	74-85	glucose-6-phosphate isomerase	Homo sapiens	16-19
9054470-2	1997	GAL is colocalized with corticotropin (ACTH) in the human pituitary and with epinephrine (E) and norepinephrine (NE) in chromaffin cells of the adrenal medulla.	Epinephrine	77-88	galanin and GMAP prepropeptide	Homo sapiens	0-3
9062902-3	1997	In FMLP-stimulated cells, the short-term burst of oxidant generation was inhibited by adrenaline in a dose-dependent fashion.	Epinephrine	86-96	formyl peptide receptor 1	Homo sapiens	3-7
9091308-1	1997	PDGF-AB and TGF-beta 1 intervene in molluscan stress response, the former inhibiting and the latter inducing the release of norepinephrine and epinephrine from hemocytes.	Epinephrine	127-138	transforming growth factor beta 1	Homo sapiens	12-22
9089407-0	1997	Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets.	Epinephrine	92-103	spleen associated tyrosine kinase	Homo sapiens	29-32
9054258-1	1997	BACKGROUND: The spinal menings have previously been shown to contain catechol-o-methyl transferase (COMT), the enzyme that metabolizes epinephrine to the inactive metabolite metanephrine.	Epinephrine	135-146	catechol-O-methyltransferase	Homo sapiens	69-98
9054258-1	1997	BACKGROUND: The spinal menings have previously been shown to contain catechol-o-methyl transferase (COMT), the enzyme that metabolizes epinephrine to the inactive metabolite metanephrine.	Epinephrine	135-146	catechol-O-methyltransferase	Homo sapiens	100-104
9054258-7	1997	RESULTS: In the presence of sodium metabisulfite, 60 +/- 6% of the epinephrine traversing the meningeal specimens was metabolized by COMT.	Epinephrine	67-78	catechol-O-methyltransferase	Homo sapiens	133-137
9054258-8	1997	In contrast, in the presence of ascorbic acid, less than 3% of the epinephrine traversing the spinal meninges was metabolized by COMT (P = 0.0001).	Epinephrine	67-78	catechol-O-methyltransferase	Homo sapiens	129-133
9054258-10	1997	CONCLUSIONS: Epinephrine permeability through the spinal meninges is low, and meningeal COMT markedly reduces the bioavailability of what little epinephrine can traverse the meninges.	Epinephrine	145-156	catechol-O-methyltransferase	Homo sapiens	88-92
9054258-11	1997	However, a clinically relevant concentration of ascorbic acid, a competitive inhibitor of COMT, almost completely blocks epinephrine metabolism and increases the bioavailability of epinephrine.	Epinephrine	121-132	catechol-O-methyltransferase	Homo sapiens	90-94
9054258-11	1997	However, a clinically relevant concentration of ascorbic acid, a competitive inhibitor of COMT, almost completely blocks epinephrine metabolism and increases the bioavailability of epinephrine.	Epinephrine	181-192	catechol-O-methyltransferase	Homo sapiens	90-94
9124395-7	1997	We conclude that epinephrine acts as an alpha2- and beta-adrenoceptor agonist and that alpha2-adrenoceptors interact with beta-adrenoceptors and vasopressin receptors but not with PGE2 receptors on cAMP accumulation.	Epinephrine	17-28	arginine vasopressin	Rattus norvegicus	145-156
9089407-8	1997	Taken together, our results suggested that the potentiation by epinephrine may be mediated via enhancement of tyrosine phosphorylation and Syk activation, in part through a decrease of intracellular cAMP levels.	Epinephrine	63-74	spleen associated tyrosine kinase	Homo sapiens	139-142
9089407-0	1997	Tyrosine phosphorylation and Syk activation are involved in thrombin-induced aggregation of epinephrine-potentiated platelets.	Epinephrine	92-103	coagulation factor II, thrombin	Homo sapiens	60-68
9089407-3	1997	This study investigated the role of tyrosine phosphorylation and Syk activation in the synergistic mechanisms between thrombin and epinephrine.	Epinephrine	131-142	spleen associated tyrosine kinase	Homo sapiens	65-68
9089407-4	1997	Although epinephrine alone (4 microM) slightly induced protein-tyrosine phosphorylation and Syk activation, the presence of epinephrine caused a shift to the left in the dose-dependence of thrombin (0.01-0.5 U/ml)-induced tyrosine phosphorylation and Syk activation, as well as platelet aggregation.	Epinephrine	9-20	spleen associated tyrosine kinase	Homo sapiens	92-95
9089407-4	1997	Although epinephrine alone (4 microM) slightly induced protein-tyrosine phosphorylation and Syk activation, the presence of epinephrine caused a shift to the left in the dose-dependence of thrombin (0.01-0.5 U/ml)-induced tyrosine phosphorylation and Syk activation, as well as platelet aggregation.	Epinephrine	124-135	coagulation factor II, thrombin	Homo sapiens	189-197
9089407-4	1997	Although epinephrine alone (4 microM) slightly induced protein-tyrosine phosphorylation and Syk activation, the presence of epinephrine caused a shift to the left in the dose-dependence of thrombin (0.01-0.5 U/ml)-induced tyrosine phosphorylation and Syk activation, as well as platelet aggregation.	Epinephrine	124-135	spleen associated tyrosine kinase	Homo sapiens	251-254
8995232-3	1997	Here we show that purified apoE (10-50 microg/ml), complexed with phospholipid vesicles (dimyristoylphosphatidylcholine, DMPC), suppresses platelet aggregation induced by ADP, epinephrine, or collagen.	Epinephrine	176-187	apolipoprotein E	Homo sapiens	27-31
9003072-0	1997	Epinephrine and norepinephrine act as potent agonists at the recombinant human dopamine D4 receptor.	Epinephrine	0-11	dopamine receptor D4	Homo sapiens	79-99
8999967-1	1997	To better characterize the translational regulation of lipoprotein lipase (LPL) by epinephrine, cytoplasmic extracts were prepared from 3T3-L1 adipocytes, 3T3-F442A adipocytes, and other nonadipocyte cell lines (C2 cells, 3T3 fibroblasts, and Chinese hamster ovary cells).	Epinephrine	83-94	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	55-73
8999967-1	1997	To better characterize the translational regulation of lipoprotein lipase (LPL) by epinephrine, cytoplasmic extracts were prepared from 3T3-L1 adipocytes, 3T3-F442A adipocytes, and other nonadipocyte cell lines (C2 cells, 3T3 fibroblasts, and Chinese hamster ovary cells).	Epinephrine	83-94	LOW QUALITY PROTEIN: lipoprotein lipase	Cricetulus griseus	75-78
8999967-2	1997	After treatment with epinephrine, cell extracts from the adipocytes inhibited LPL translation in an in vitro translation assay, whereas extracts from the C2 cells and 3T3 fibroblasts did not affect LPL translation.	Epinephrine	21-32	lipoprotein lipase	Mus musculus	78-81
8999967-9	1997	The epinephrine-treated cell extract protected a fragment of RNA when the RNA included sequences on the proximal 3" UTR of LPL.	Epinephrine	4-15	lipoprotein lipase	Mus musculus	123-126
8999967-11	1997	Thus, the addition of epinephrine to 3T3 adipocytes results in an inhibition of translation through the production of a RNA-binding protein that binds to a region on the proximal 3" UTR of the LPL mRNA.	Epinephrine	22-33	lipoprotein lipase	Mus musculus	193-196
9121699-1	1997	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa.	Epinephrine	89-99	catechol-O-methyltransferase	Homo sapiens	0-28
9121699-1	1997	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates catecholamines such as adrenaline, noradrenaline, dopamine, and levodopa.	Epinephrine	89-99	catechol-O-methyltransferase	Homo sapiens	30-34
9021920-1	1997	Epinephrine inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF) production by increasing intracellular cAMP concentrations.	Epinephrine	0-11	tumor necrosis factor	Homo sapiens	77-80
9021920-7	1997	These data suggest that epinephrine not only influences the bioavailability of TNF by an effect on the production of this proinflammatory cytokine, but also by modulating the expression of its receptors.	Epinephrine	24-35	tumor necrosis factor	Homo sapiens	79-82
9005952-9	1997	Our results show that P-selectin expression on WP increases significantly upon stimulation with thrombin (0.1-1.0 U/ml), ADP (10 microM) and epinephrine (100 microM).	Epinephrine	141-152	selectin P	Homo sapiens	22-32
9058482-9	1997	The surface expression of GPIIb/IIIa was markedly decreased in platelets from NR after stimulation by epinephrine, in comparison with those from R. The resting level and epinephrine stimulated increase in cAMP were not significantly different between NR and R. Incubating R platelets with a half saturating dose of yohimbine rendered them insensitive to epinephrine.	Epinephrine	102-113	integrin subunit alpha 2b	Homo sapiens	26-31
9058482-9	1997	The surface expression of GPIIb/IIIa was markedly decreased in platelets from NR after stimulation by epinephrine, in comparison with those from R. The resting level and epinephrine stimulated increase in cAMP were not significantly different between NR and R. Incubating R platelets with a half saturating dose of yohimbine rendered them insensitive to epinephrine.	Epinephrine	170-181	integrin subunit alpha 2b	Homo sapiens	26-31
9058482-9	1997	The surface expression of GPIIb/IIIa was markedly decreased in platelets from NR after stimulation by epinephrine, in comparison with those from R. The resting level and epinephrine stimulated increase in cAMP were not significantly different between NR and R. Incubating R platelets with a half saturating dose of yohimbine rendered them insensitive to epinephrine.	Epinephrine	170-181	integrin subunit alpha 2b	Homo sapiens	26-31
9058482-10	1997	These results indicated that the impaired platelet aggregation induced by epinephrine was due to the impaired surface exposure of glycoproteins GPIIbIIIa integral to the activation of phospholipase A2, which requires the full and normal occupancy of the alpha 2-adrenergic receptor by epinephrine.	Epinephrine	74-85	phospholipase A2 group IB	Homo sapiens	184-200
9058482-10	1997	These results indicated that the impaired platelet aggregation induced by epinephrine was due to the impaired surface exposure of glycoproteins GPIIbIIIa integral to the activation of phospholipase A2, which requires the full and normal occupancy of the alpha 2-adrenergic receptor by epinephrine.	Epinephrine	285-296	phospholipase A2 group IB	Homo sapiens	184-200
8990146-5	1997	In contrast, neuron-like cells (and to a variable extent intermediate cells) displayed selective loss of expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine.	Epinephrine	194-205	phenylethanolamine N-methyltransferase	Homo sapiens	119-157
8990146-5	1997	In contrast, neuron-like cells (and to a variable extent intermediate cells) displayed selective loss of expression of phenylethanolamine-N-methyltransferase (PNMT), the enzyme that synthesizes epinephrine.	Epinephrine	194-205	phenylethanolamine N-methyltransferase	Homo sapiens	159-163
9038921-3	1997	In the rostral ventrolateral medulla, FLI distribution in neurons containing phenylethanolamine-N-methyltransferase (PNMT, the synthetic enzyme for epinephrine) was also observed utilizing double-labeling methods.	Epinephrine	148-159	phenylethanolamine N-methyltransferase	Felis catus	77-115
9038921-3	1997	In the rostral ventrolateral medulla, FLI distribution in neurons containing phenylethanolamine-N-methyltransferase (PNMT, the synthetic enzyme for epinephrine) was also observed utilizing double-labeling methods.	Epinephrine	148-159	phenylethanolamine N-methyltransferase	Felis catus	117-121
9038987-3	1997	The elevation of plasma norepinephrine and epinephrine induced by immobilization stress was also suppressed by central ANG II-receptor blockade, suggesting a general attenuation of stress-induced sympathetic nervous and adrenomedullary activity by central ANG II-receptor blockade.	Epinephrine	27-38	angiotensinogen	Rattus norvegicus	119-125
9170549-6	1997	Recent studies of the hyperadrenergic (elevated plasma norepinephrine) subgroup of orthostatic intolerance is documenting a clinical spectrum including attenuated plasma renin activity and aldosterone, reduced supine blood volume coupled with dynamic orthostatic hypovolemia, elevated plasma norepinephrine and epinephrine, impaired clearance of norepinephrine from the circulation and evidence of partial dysautonomia.	Epinephrine	58-69	renin	Homo sapiens	170-175
9471921-17	1997	The daily excretion of adrenaline and noradrenaline in urine concentrations of dopamine in plasma of women chronically exposed to CS2, was significantly lower (p &lt; 0.001), but the serum concentrations of serotonin (Tab.	Epinephrine	23-33	chorionic somatomammotropin hormone 2	Homo sapiens	130-133
9005974-0	1997	Acute effects of adrenaline on hepatic lipase secretion by rat hepatocytes.	Epinephrine	17-27	lipase C, hepatic type	Rattus norvegicus	31-45
9005974-2	1997	We have studied the mechanism by which adrenaline decreases HL secretion in suspensions of freshly isolated rat hepatocytes.	Epinephrine	39-49	lipase C, hepatic type	Rattus norvegicus	60-62
9005974-3	1997	Adrenaline acutely inhibited HL activity through activation of the alpha1-adrenergic pathway.	Epinephrine	0-10	lipase C, hepatic type	Rattus norvegicus	29-31
9005974-4	1997	The cells had significantly less HL activity in the presence of adrenaline versus cycloheximide, where protein de novo synthesis is completely blocked.	Epinephrine	64-74	lipase C, hepatic type	Rattus norvegicus	33-35
9005974-6	1997	Intracellular HL activity was decreased by adrenaline treatment.	Epinephrine	43-53	lipase C, hepatic type	Rattus norvegicus	14-16
9005974-12	1997	We conclude that adrenaline inhibits HL secretion posttranslationally by retarding the maturation of the 53-kd HL precursor to an active 58-kd protein, possibly by stimulating degradation of newly synthesized HL protein.	Epinephrine	17-27	lipase C, hepatic type	Rattus norvegicus	37-39
9005974-12	1997	We conclude that adrenaline inhibits HL secretion posttranslationally by retarding the maturation of the 53-kd HL precursor to an active 58-kd protein, possibly by stimulating degradation of newly synthesized HL protein.	Epinephrine	17-27	lipase C, hepatic type	Rattus norvegicus	111-113
9005974-12	1997	We conclude that adrenaline inhibits HL secretion posttranslationally by retarding the maturation of the 53-kd HL precursor to an active 58-kd protein, possibly by stimulating degradation of newly synthesized HL protein.	Epinephrine	17-27	lipase C, hepatic type	Rattus norvegicus	111-113
9245500-5	1997	Immunofluorescence experiments using antibodies specific for the SERT COOH and NH2 termini, for 5HT, or for catecholamine biosynthetic enzymes suggest that SERT mediates intra-cellular 5HT accumulation by epinephrine-secreting chromaffin cells.	Epinephrine	205-216	solute carrier family 6 member 4	Rattus norvegicus	156-160
9230639-6	1997	Relative increases in insulin correlated with increases in epinephrine after active drug.	Epinephrine	59-70	insulin	Homo sapiens	22-29
16793654-2	1997	P-selectin expression in response to no added stimulus (spontaneous activation) or in response to adenosine diphosphate (ADP) and epinephrine or thrombin, was assessed using a flow cytometric assay.	Epinephrine	130-141	selectin, platelet	Mus musculus	0-10
8948062-2	1996	We have demonstrated that low concentration of epinephrine could reduce the threshold level of shear rate necessary to cause platelet activation with purified system devoid of the effect of plasma proteins other than vWF.	Epinephrine	47-58	von Willebrand factor	Homo sapiens	217-220
9068827-6	1997	Epinephrine, the adenylate cyclase activator forskolin, the cAMP analog dibutyryl-cAMP, and the phosphodiesterase inhibitor isobutylmethylxanthine all increase aqueous facility.	Epinephrine	0-11	cathelicidin-7	Bos taurus	82-86
9068827-7	1997	It seems reasonable to suspect that the cAMP system is involved in epinephrine"s effects on bovine trabecular meshwork cells.	Epinephrine	67-78	cathelicidin-7	Bos taurus	40-44
8968543-19	1996	The functional presence of beta 2-adrenoceptor-responses in SHR-ADM4 suggests a major role for adrenal-derived adrenaline in the desensitization of the beta 2-adrenoceptor-population.	Epinephrine	111-121	adrenoceptor beta 2	Rattus norvegicus	27-46
8968543-19	1996	The functional presence of beta 2-adrenoceptor-responses in SHR-ADM4 suggests a major role for adrenal-derived adrenaline in the desensitization of the beta 2-adrenoceptor-population.	Epinephrine	111-121	adrenoceptor beta 2	Rattus norvegicus	152-171
8982098-5	1996	Treatment of the macrophages with propranolol, a beta-antagonist, potentiated the effect of epinephrine.	Epinephrine	92-103	amyloid beta (A4) precursor protein	Mus musculus	47-53
8948062-7	1996	Aggregation and rise in [Ca2+]i under low shear in the presence of epinephrine was abolished by monoclonal antibodies against A1 domain of vWF or GP Ib, like aggregation and the rise in [Ca2+]i occurred under high shear rate (10,800 s-1), alpha 2-receptor blockade yohimbine completely antagonized the enhancing effects of epinephrine.	Epinephrine	67-78	von Willebrand factor	Homo sapiens	139-142
8948062-7	1996	Aggregation and rise in [Ca2+]i under low shear in the presence of epinephrine was abolished by monoclonal antibodies against A1 domain of vWF or GP Ib, like aggregation and the rise in [Ca2+]i occurred under high shear rate (10,800 s-1), alpha 2-receptor blockade yohimbine completely antagonized the enhancing effects of epinephrine.	Epinephrine	323-334	von Willebrand factor	Homo sapiens	139-142
8958491-5	1996	It is concluded that adrenaline at 5 micrograms mL-1 significantly prolongs the first stage of labour.	Epinephrine	21-31	L1 cell adhesion molecule	Mus musculus	48-52
8945965-3	1996	The regulation of LPL in gluteal adipose tissue and vastus lateralis muscle by isoproterenol (epinephrine isopropyl homologue) in humans was examined over 2 h in subjects infused with 0 (saline) or 8 or 24 ng.kg-1.min-1 isoproterenol.	Epinephrine	94-105	lipoprotein lipase	Homo sapiens	18-21
8978485-10	1996	Because a similar mechanism of LPL regulation occurs in response to epinephrine, the absence of the translation repressor may be a mechanism for the loss of sensitivity of hypothyroid cells for catecholamines.	Epinephrine	68-79	lipoprotein lipase	Rattus norvegicus	31-34
8931644-1	1996	The rate of protein synthesis was assessed in muscle, lymphocytes, and albumin in healthy volunteers administered an infusion of 6.0 micrograms cortisol +3.0 ng glucagon +0.5 nmol epinephrine min-1.kg-1.	Epinephrine	180-191	CD59 molecule (CD59 blood group)	Homo sapiens	192-197
8826974-0	1996	Epinephrine exerts opposite effects on peripheral glucose disposal and glucose-stimulated insulin secretion.	Epinephrine	0-11	insulin	Homo sapiens	90-97
8902188-2	1996	In the present study, we determined the effects of fasting and the infusion of insulin, glucose, and/or epinephrine on the liver cytosolic mRNA levels of the gene for the key regulatory enzyme of gluconeogenesis, phosphoenolpyruvate carboxykinase PEPCK (PEPCK; EC 4.1.1.32), in newborn dogs in vivo to further test the hypothesis.	Epinephrine	104-115	phosphoenolpyruvate carboxykinase 1	Canis lupus familiaris	247-252
8902188-2	1996	In the present study, we determined the effects of fasting and the infusion of insulin, glucose, and/or epinephrine on the liver cytosolic mRNA levels of the gene for the key regulatory enzyme of gluconeogenesis, phosphoenolpyruvate carboxykinase PEPCK (PEPCK; EC 4.1.1.32), in newborn dogs in vivo to further test the hypothesis.	Epinephrine	104-115	phosphoenolpyruvate carboxykinase 1	Canis lupus familiaris	254-259
8902188-7	1996	(iv) In newborn dogs, despite the presence of hyperinsulinemia and hyperglycemia, the infused epinephrine was still able to elevate the liver PEPCK mRNA from undetectable levels to 79% of the control levels.	Epinephrine	94-105	phosphoenolpyruvate carboxykinase 1	Canis lupus familiaris	142-147
8983867-2	1996	Adrenaline was infused at a rate of 25 ng min-1 kg-1 into seven healthy volunteers and its effects on adipose tissue were studied by microdialysis.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	42-52
8938587-14	1996	Levels of mRNA encoding the glucocorticoid-dependent enzyme phenylethanolamine N-methyltransferase which catalyses the conversion of noradrenaline to adrenaline, were also significantly reduced in those rats given glycyrrhizic acid (1.12 +/- 0.04 vs 0.78 +/- 0.04), while those for the glucocorticoid-independent enzyme tyrosine hydroxylase (1.9 kb), which catalyses the conversion of tyrosine to DOPA, were unchanged (0.64 +/- 0.04 vs 0.61 +/- 0.04).	Epinephrine	136-146	phenylethanolamine-N-methyltransferase	Rattus norvegicus	60-98
8855809-6	1996	Further, hydrocortisone reversed the increase in IL-10 concentrations by epinephrine in LPS-stimulated whole blood.	Epinephrine	73-84	interleukin 10	Homo sapiens	49-54
8938587-17	1996	This, together with our in vivo studies, suggests that 11 beta-HSD1 may play an important role with respect to adrenocorticosteroid regulation of adrenaline biosynthesis.	Epinephrine	146-156	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	55-67
8933243-5	1996	CGRP inhibited platelet aggregation in vitro in 19 of the subjects (90.5%) in a dose-dependent manner with 50% inhibitory doses of 1.6 mumol/L and 1.1 mumol/L for aggregation induced by epinephrine and collagen, respectively.	Epinephrine	186-197	calcitonin related polypeptide alpha	Homo sapiens	0-4
8902889-1	1996	Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline.	Epinephrine	95-105	catechol-O-methyltransferase	Homo sapiens	0-29
8902889-1	1996	Catechol-O-methyl transferase (COMT) metabolizes a variety of catecholamines such as dopamine, adrenaline and noradrenaline.	Epinephrine	95-105	catechol-O-methyltransferase	Homo sapiens	31-35
9438155-12	1996	CONCLUSION: It is concluded that beta-endorphin IRM concentration in the plasma is linked to epinephrine and norepinephrine concentrations under intensive care conditions.	Epinephrine	93-104	proopiomelanocortin	Homo sapiens	33-47
8889050-2	1996	The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) protein content from mouse liver significantly increased in the orally GR-treated normal and epinephrine-induced hyperglycemic mice compared to that in the controls.	Epinephrine	199-210	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	23-97
8843757-5	1996	A positive correlation was observed between peak plasma epinephrine or norepinephrine and IL-6 levels at 15 min.	Epinephrine	56-67	interleukin 6	Homo sapiens	90-94
8889050-2	1996	The hepatic content of facilitative glucose transporter isoform 2, liver type glucose transporter (GLUT2) protein content from mouse liver significantly increased in the orally GR-treated normal and epinephrine-induced hyperglycemic mice compared to that in the controls.	Epinephrine	199-210	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	99-104
8886597-3	1996	Heart rate and concentrations of blood glucose, plasma free fatty acids, and lactate increased (P &lt; 0.01), whereas plasma insulin concentrations tended to decrease (P &lt; 0.06) during epinephrine infusion.	Epinephrine	188-199	LOC105613195	Ovis aries	125-132
8918684-10	1996	Although urinary adrenaline/creatinine (A/C) ratios were significantly correlated with maximum plasma adrenaline values after insulin administration, A/C ratios did not differ significantly between insulin and saline treatment.	Epinephrine	17-27	insulin	Canis lupus familiaris	126-133
8877775-1	1996	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the pathway for epinephrine biosynthesis, serves as a marker for tissues and cells producing epinephrine.	Epinephrine	83-94	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
8784081-5	1996	IFN alpha induced increases in plasma concentrations of norepinephrine (225 +/- 93%; P &lt; 0.02 vs. control), epinephrine (272 +/- 80%; P &lt; 0.05), cortisol (353 +/- 63%; P &lt; 0.02), glucagon (50 +/- 12%; P &lt; 0.05), free fatty acids (223 +/- 61%; P &lt; 0.02), and glycerol (68 +/- 21%; P &lt; 0.02) and in resting energy expenditure (36 +/- 50%; P &lt; 0.03).	Epinephrine	59-70	interferon alpha 1	Homo sapiens	0-9
8902882-5	1996	Norepinephrine and epinephrine also suppressed IL-12 production in a dose-dependent fashion and at physiological concentrations; both catecholamines, however, dose-dependently increased the production of IL-10.	Epinephrine	3-14	interleukin 10	Homo sapiens	204-209
8770022-7	1996	Epinephrine completely reversed insulin"s activation of muscle glycogen synthase in both groups.	Epinephrine	0-11	insulin	Homo sapiens	32-39
8856476-0	1996	Intracellular levels of cyclic AMP and cyclic GMP differentially modify platelet aggregate size in human platelets activated with epinephrine or ADP.	Epinephrine	130-141	5'-nucleotidase, cytosolic II	Homo sapiens	46-49
8856476-6	1996	On the other hand, nitroprusside, which increases intracellular cyclic GMP, inhibited only the formation of large aggregates, with an ID50 value of 454 +/- 191 nM for epinephrine-induced activation and of 2.1 +/- 0.6 microM for ADP-induced activation.	Epinephrine	167-178	5'-nucleotidase, cytosolic II	Homo sapiens	71-74
8856476-9	1996	Milrinone, which increases the intracellular level of both cyclic AMP and cyclic GMP, suppressed the formation of small and large aggregates induced by epinephrine and ADP.	Epinephrine	152-163	5'-nucleotidase, cytosolic II	Homo sapiens	81-84
8856476-10	1996	These findings suggest that cyclic AMP and cyclic GMP differentially modify the size of aggregates formed during epinephrine or ADP activation.	Epinephrine	113-124	5'-nucleotidase, cytosolic II	Homo sapiens	50-53
8784263-5	1996	In the present study we demonstrate that: (i) promoter usage and splicing of PENK mRNA function similarly in mesenteric lymph nodes as in neural cells; (2) PENK expression in mesenteric lymph nodes is modulated by adrenaline via adrenergic receptors; and (3) the adrenergic system participates in the modulation of the LPS induced PENK mRNA expression.	Epinephrine	214-224	proenkephalin	Rattus norvegicus	77-81
8784263-5	1996	In the present study we demonstrate that: (i) promoter usage and splicing of PENK mRNA function similarly in mesenteric lymph nodes as in neural cells; (2) PENK expression in mesenteric lymph nodes is modulated by adrenaline via adrenergic receptors; and (3) the adrenergic system participates in the modulation of the LPS induced PENK mRNA expression.	Epinephrine	214-224	proenkephalin	Rattus norvegicus	156-160
8784263-5	1996	In the present study we demonstrate that: (i) promoter usage and splicing of PENK mRNA function similarly in mesenteric lymph nodes as in neural cells; (2) PENK expression in mesenteric lymph nodes is modulated by adrenaline via adrenergic receptors; and (3) the adrenergic system participates in the modulation of the LPS induced PENK mRNA expression.	Epinephrine	214-224	proenkephalin	Rattus norvegicus	156-160
8910846-4	1996	Compound 4, 2-[3-(isopropylamino)-2-hydroxypropoxylxanthone hydrochloride salt and 2,5 dihydroxyxanthone suppressed the secondary aggregation induced by adrenaline in human PRP.	Epinephrine	153-163	complement component 4 binding protein alpha	Homo sapiens	173-176
8759396-7	1996	Ana-guard injector is recommended for the allergic adult due to its easy handling and the fact that it contains two doses of adrenaline 0.3 mg. For both children and adults with a low bodyweight, the Epi-Pen automatic injector is recommended.	Epinephrine	125-135	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	204-207
8877775-1	1996	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the pathway for epinephrine biosynthesis, serves as a marker for tissues and cells producing epinephrine.	Epinephrine	83-94	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
8877775-1	1996	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the pathway for epinephrine biosynthesis, serves as a marker for tissues and cells producing epinephrine.	Epinephrine	160-171	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
8877775-1	1996	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the pathway for epinephrine biosynthesis, serves as a marker for tissues and cells producing epinephrine.	Epinephrine	160-171	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
8877775-5	1996	PNMT has not previously been reported to be expressed at these early stages of development, and its presence in the developing heart suggests that this embryonic tissue may produce epinephrine.	Epinephrine	181-192	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-4
8674891-5	1996	With a 2-h insulin infusion, serum norepinephrine, epinephrine, plasminogen activator inhibitor 1, and intraplatelet Ca2+ decreased significantly, but 6-keto-prostaglandin (PG) F1 alpha and PGE2 did not change.	Epinephrine	38-49	insulin	Homo sapiens	11-18
8678641-7	1996	Interleukin-6 correlated with duration of extracorporeal circulation, dose of norepinephrine and epinephrine support, pulmonary capillary wedge pressure, mean pulmonary arterial pressure, right atrial pressure, heart rate, cardiac index, and inversely with systemic vascular resistance.	Epinephrine	81-92	interleukin 6	Homo sapiens	0-13
8809522-9	1996	(2) In mode 10/60 s, heart rate and systolic blood pressure increased significantly (82 +/- 4 --&gt; 85 +/- 4 beats.min-1; 124 +/- 5 --&gt; 134 +/- 5 mmHg; P &lt; 0.05 each), while in mode 15/60 s catecholamines increased significantly (norepinephrine 0.804 +/- 0.089 --&gt; 1.135 +/- 0.094 nmol.l-1; P &lt; 0.008; epinephrine 0.136 +/- 0.012 --&gt; 0.193 +/- 0.019 nmol.l-1; P &lt; 0.005).	Epinephrine	240-251	CD59 molecule (CD59 blood group)	Homo sapiens	116-121
8666149-5	1996	Insulin-induced hypoglycemia (plasma glucose = 1.9 +/- 0.1 mmol/l) activated parasympathetic nerves to the pancreas as assessed by increased plasma pancreatic polypeptide (PP) levels (delta = 135.0 +/- 36.8 pmol/l, P &lt; 0.01), produced sympathoadrenal activation as assessed by elevations of plasma epinephrine (EPI) (delta = 22.3 +/- 2.95 nmol/l, P &lt; 0.0005) and norepinephrine (NE) (delta = 3.72 +/- 0.77 mmol/l, P &lt; 0.0025) and increased plasma immunoreactive glucagon (IRG) (delta = 920 +/- 294 ng/l, P &lt; 0.025).	Epinephrine	301-312	insulin	Canis lupus familiaris	0-7
8817361-0	1996	Insulin and glucagon responses to adrenaline infusion in abdominal obese men.	Epinephrine	34-44	insulin	Homo sapiens	0-7
8670175-7	1996	In addition, experiments in vitro indicate that low millimolar amounts of either adrenaline (IC50 5.2 mM) or noradrenaline (IC50 2.4 mM) can significantly impair the proteolytic activity of recombinant murine prohormone convertase 1 when assayed with synthetic fluorogenic and/or peptidyl substrates.	Epinephrine	81-91	proprotein convertase subtilisin/kexin type 1	Mus musculus	209-232
8685936-5	1996	Five minutes after drug administration, cerebral venous Pco2 was 63 (59; 68) mm Hg in the epinephrine group and 47 (43; 55) mm Hg in the vasopressin group (P&lt;.01); at the same time cerebral venous pH was 7.18 (7.17; 7.20) and 7.26 (7.22; 7.36) (P&lt;.01) in the epinephrine and vasopressin groups, respectively.	Epinephrine	90-101	PCO2	Sus scrofa	56-60
8633820-1	1996	BACKGROUND: Successful outcomes after cardiopulmonary resuscitation remain disappointingly infrequent, in animal studies, administration of exogenous vasopressin during closed- and open-chest cardiopulmonary resuscitation has recently been shown to be more effective than optimal doses of epinephrine in improving vital organ blood flow.	Epinephrine	289-300	arginine vasopressin	Homo sapiens	150-161
10968201-3	1996	EPO treatment was associated with significant increases in Hgb (7.1 +/- 1.4 to 8.4 +/- 1.8 g/dl, p&lt;0.01), mean BP (103 +/- 11.4 to 116 +/- 19.9 mmHg, p&lt;0.01), [Na+]i (4.99 +/- 0.78 to 6.22 +/- 0.96 mmol/l, p&lt;0.01) and BV (1.39 +/- 0.14 to 1.53 +/- 0.18 c.p., p&lt;0.05), but no significant alteration in PRA, PAC, Ad, NAd, ANP, or in the serum concentration of Na+, K+, and Ca2+.	Epinephrine	323-325	erythropoietin	Homo sapiens	0-3
8639835-5	1996	Epinephrine (1 micromol/L), which does not induce platelet aggregation in hirudin platelet rich plasma (PRP), did so in the presence of thrombopoietin (10 ng/mL).	Epinephrine	0-11	thrombopoietin	Homo sapiens	136-150
8639835-12	1996	The priming effect on epinephrine-induced platelet aggregation in hirudin PRP was unique to thrombopoietin, with no effects seen using interleukin-6 (IL-6), IL-11, IL-3, erythropoietin, granulocyte-colony stimulating factor, granulocyte macrophage-colony stimulating factor, or c-kit ligand.	Epinephrine	22-33	thrombopoietin	Homo sapiens	92-106
8639835-12	1996	The priming effect on epinephrine-induced platelet aggregation in hirudin PRP was unique to thrombopoietin, with no effects seen using interleukin-6 (IL-6), IL-11, IL-3, erythropoietin, granulocyte-colony stimulating factor, granulocyte macrophage-colony stimulating factor, or c-kit ligand.	Epinephrine	22-33	KIT ligand	Homo sapiens	278-290
8620226-8	1996	Based on the physician assessment of achievement of complete, partial, or no anesthesia, solutions containing 11.8% cocaine (TAC 1) and 4% cocaine with adrenaline (TAC 2) were more likely to produce complete anesthesia than the solution with 4% cocaine without adrenaline (TAC 3) (P &lt; .001, chi 2).	Epinephrine	152-162	tachykinin precursor 1	Homo sapiens	164-169
8909778-5	1996	After addition of 1 microM butoxamine, a beta 2-adrenoceptor antagonist, the tissues from stressed rats were subsensitive to adrenaline.	Epinephrine	125-135	adrenoceptor beta 2	Rattus norvegicus	41-60
8813375-1	1996	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE) and epinephrine (Epi).	Epinephrine	96-107	monoamine oxidase A	Rattus norvegicus	51-70
8813375-1	1996	3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is the monoamine oxidase A (MAO-A) metabolite of norepinephrine (NE) and epinephrine (Epi).	Epinephrine	96-107	monoamine oxidase A	Rattus norvegicus	72-77
8935180-8	1996	However, the combination of epinephrine and shear stress induced platelet aggregation that was blocked by 10E5, a monoclonal antibody that inhibits vWF binding to Gp IIb/IIIa, but not by aurin tricarboxylic acid or the monoclonal antibody 6D1, both of which inhibit vWF binding to Gp Ib.	Epinephrine	28-39	von Willebrand factor	Homo sapiens	148-151
8935180-8	1996	However, the combination of epinephrine and shear stress induced platelet aggregation that was blocked by 10E5, a monoclonal antibody that inhibits vWF binding to Gp IIb/IIIa, but not by aurin tricarboxylic acid or the monoclonal antibody 6D1, both of which inhibit vWF binding to Gp Ib.	Epinephrine	28-39	integrin subunit alpha 2b	Homo sapiens	163-169
8935180-8	1996	However, the combination of epinephrine and shear stress induced platelet aggregation that was blocked by 10E5, a monoclonal antibody that inhibits vWF binding to Gp IIb/IIIa, but not by aurin tricarboxylic acid or the monoclonal antibody 6D1, both of which inhibit vWF binding to Gp Ib.	Epinephrine	28-39	von Willebrand factor	Homo sapiens	266-269
9053060-1	1996	Corticotropin-releasing hormone administration into the neostriatum was shown to increase the level of corticosterone in the blood, as well as adrenaline and noradrenaline contents in the adrenal glands.	Epinephrine	143-153	corticotropin releasing hormone	Homo sapiens	0-31
8737076-3	1996	Dopamine, noradrenaline and adrenaline enter the red blood cell by a similar process, which shows saturation kinetics with Vmax values of 0.54 +/- 0.12, 0.48 +/- 0.08 and 0.63 +/- 0.13 mumol (1 cells)-1 min-1, respectively, and K(m) values of 15.62 +/- 1.19, 5.81 +/- 1.19 and 12.00 +/- 2.97 nM, respectively.	Epinephrine	13-23	CD59 molecule (CD59 blood group)	Homo sapiens	203-208
8738299-1	1996	We have reported that chronic treatment of patients with beta 1-adrenoceptor blockers sensitises isolated atrial preparations to adrenaline, noradrenaline and 5-Ht.	Epinephrine	129-139	adrenoceptor beta 1	Homo sapiens	57-76
8639892-6	1996	MGDF also "primed" the release of adenosine triphosphates and the production of thromboxane B2 by platelets stimulated with ADP, EPI, and THR.	Epinephrine	129-132	thrombopoietin	Homo sapiens	0-4
8792338-7	1996	Overall, a 30-fold range of GTP cyclohydrolase I mRNA expression was observed, with the transcript being significantly more abundant in serotonin than in dopamine or norepinephrine/epinephrine neurons.	Epinephrine	169-180	GTP cyclohydrolase 1	Rattus norvegicus	28-48
8792338-10	1996	Norepinephrine neurons of the locus coeruleus (A6) and subcoeruleus (A6v) exhibited significantly higher levels of GTP cyclohydrolase I mRNA than did neurons in other norepinephrine (A1 and A2) or epinephrine (C1 and C2) cell groups.	Epinephrine	3-14	GTP cyclohydrolase 1	Rattus norvegicus	115-135
8792338-10	1996	Norepinephrine neurons of the locus coeruleus (A6) and subcoeruleus (A6v) exhibited significantly higher levels of GTP cyclohydrolase I mRNA than did neurons in other norepinephrine (A1 and A2) or epinephrine (C1 and C2) cell groups.	Epinephrine	3-14	complement C2	Rattus norvegicus	210-219
8902860-9	1996	Considering the general trend to noninvasive therapy in children and the more frequent adverse effects after epinephrine injection, such nebulized beta-2 agonists as terbutaline appear preferable for initial therapy of acute asthma if oxygen is supplemented to prevent possible hypoxemia.	Epinephrine	109-120	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	147-153
8603584-5	1996	Treatment with IGF-I also decreased (P &lt; 0.1) GH secretion in response to a GRF load, but significantly (P &lt; 0.05) increased the nonesterified fatty acid response to an epinephrine load.	Epinephrine	175-186	insulin-like growth factor I	Ovis aries	15-20
8733886-0	1996	Effects of insulin, epinephrine, and glucose on regulation of transcription of the serine dehydratase gene in newborn dogs.	Epinephrine	20-31	L-serine dehydratase/L-threonine deaminase	Canis lupus familiaris	83-101
8730750-7	1996	These results indicate that systemic TNF alpha production is regulated by adrenaline but not by corticosterone.	Epinephrine	74-84	tumor necrosis factor	Mus musculus	37-46
8700892-2	1996	In cell lines stably expressing alpha1B- adrenergic receptors, activation of these receptors by epinephrine resulted in an activation of cytosolic betaARK.	Epinephrine	96-107	G protein-coupled receptor kinase 2	Homo sapiens	147-154
8733886-5	1996	The results showed that insulins, glucose, and epinephrine did not change the kidney SDH mRNA level; hyperinsulinemia and hyperglycemia reduced the liver SDH mRNA level by 8.5 and 29.2%, respectively; in the presence of hyperglycemia and hyperinsulinemia, epinephrine was able to increase the liver SDH mRNA by 27.8%, almost offsetting the reduction of the liver SDH mRNA level induced by the combination of insulin and glucose.	Epinephrine	256-267	serine dehydratase	Rattus norvegicus	154-157
8733886-5	1996	The results showed that insulins, glucose, and epinephrine did not change the kidney SDH mRNA level; hyperinsulinemia and hyperglycemia reduced the liver SDH mRNA level by 8.5 and 29.2%, respectively; in the presence of hyperglycemia and hyperinsulinemia, epinephrine was able to increase the liver SDH mRNA by 27.8%, almost offsetting the reduction of the liver SDH mRNA level induced by the combination of insulin and glucose.	Epinephrine	256-267	serine dehydratase	Rattus norvegicus	154-157
8733886-6	1996	We conclude that the enhanced regulatory effect of epinephrine counteracting insulin on SDH gene transcription in liver of newborn dogs may be one of the mechanisms responsible for the neonatal insulin resistance which contributes to neonatal hyperglycemia.	Epinephrine	51-62	insulin	Canis lupus familiaris	77-84
8733886-6	1996	We conclude that the enhanced regulatory effect of epinephrine counteracting insulin on SDH gene transcription in liver of newborn dogs may be one of the mechanisms responsible for the neonatal insulin resistance which contributes to neonatal hyperglycemia.	Epinephrine	51-62	serine dehydratase	Rattus norvegicus	88-91
8612391-14	1996	Other mechanisms are capable of regulating the concentrations of norepinephrine and epinephrine in circulating blood (and apparently also at receptors in the heart and vascular tissue) when both COMT and MAO-A activity are inhibited to a significant extent.	Epinephrine	68-79	catechol-O-methyltransferase	Homo sapiens	195-199
8792101-0	1996	Counterregulation by epinephrine and glucagon during insulin-induced hypoglycemia in the conscious dog.	Epinephrine	21-32	insulin	Canis lupus familiaris	53-60
8792101-9	1996	In conclusion, a normal rise in epinephrine appears to be required to elicit an increase in glucagon during insulin-induced hypoglycemia in the dog.	Epinephrine	32-43	insulin	Canis lupus familiaris	108-115
8792101-10	1996	During insulin-induced hypoglycemia, epinephrine plays a major role in maintaining an elevated rate of glucose production, probably via muscle lactate release and hepatic lactate uptake.	Epinephrine	37-48	insulin	Canis lupus familiaris	7-14
8636443-4	1996	Epinephrine- and PMA-promoted AA release and activation of the PLA2 were inhibited by AACOCF3, an inhibitor of the 85-kD cPLA2.	Epinephrine	0-11	phospholipase A2 group IB	Canis lupus familiaris	63-67
8617782-2	1996	Coexpression of beta-adrenergic receptor kinase (betaARK) 1 (GRK2) or 2 (GRK3) could increase epinephrine-induced phosphorylation of the wild type alpha1BAR above basal as compared to that of the receptor expressed alone.	Epinephrine	94-105	G protein-coupled receptor kinase 2	Homo sapiens	16-59
8617782-2	1996	Coexpression of beta-adrenergic receptor kinase (betaARK) 1 (GRK2) or 2 (GRK3) could increase epinephrine-induced phosphorylation of the wild type alpha1BAR above basal as compared to that of the receptor expressed alone.	Epinephrine	94-105	G protein-coupled receptor kinase 2	Homo sapiens	61-65
8617782-2	1996	Coexpression of beta-adrenergic receptor kinase (betaARK) 1 (GRK2) or 2 (GRK3) could increase epinephrine-induced phosphorylation of the wild type alpha1BAR above basal as compared to that of the receptor expressed alone.	Epinephrine	94-105	G protein-coupled receptor kinase 3	Homo sapiens	73-77
8617782-2	1996	Coexpression of beta-adrenergic receptor kinase (betaARK) 1 (GRK2) or 2 (GRK3) could increase epinephrine-induced phosphorylation of the wild type alpha1BAR above basal as compared to that of the receptor expressed alone.	Epinephrine	94-105	adrenoceptor alpha 1B	Homo sapiens	147-156
8617782-4	1996	Overexpression of GRK6 could also increase epinephrine-induced phosphorylation of the receptor, whereas GRK5 enhanced basal but not agonist-induced phosphorylation of the alpha1BAR.	Epinephrine	43-54	G protein-coupled receptor kinase 6	Homo sapiens	18-22
8866876-8	1996	In another trial (120 min duration), adrenaline was infused (AI) at 0.1 microgram kg-1 min-1 and plasma catecholamine levels were elevated 6 pmol ml-1 above SI during the 60-120 min period.	Epinephrine	37-47	CD59 molecule (CD59 blood group)	Homo sapiens	87-92
8769853-3	1996	Induction of hsp27 was markedly enhanced when cells were exposed to arsenite in the presence of isoproterenol (20 microM) or epinephrine (20 microM) but not in the presence of phenylephrine.	Epinephrine	125-136	heat shock protein family B (small) member 1	Rattus norvegicus	13-18
8608229-6	1996	Third, the cathepsin G-, TRAP-, and ADP/epinephrine-induced decreases in platelet surface GPV were fully reversible.	Epinephrine	40-51	cathepsin G	Homo sapiens	11-22
8798235-0	1996	The effect of epinephrine on immunoreactive insulin levels in man: 1965.	Epinephrine	14-25	insulin	Homo sapiens	44-51
8849631-6	1996	Increases in norepinephrine levels and in diastolic blood pressure were nonsignificantly related to increases in BTG levels (ps &lt; .10), whereas increases in epinephrine levels were unrelated.	Epinephrine	16-27	pro-platelet basic protein	Homo sapiens	113-116
8666056-2	1996	The rank order of potency at the rat aorta was the same as that obtained for binding affinity at the rat clonal alpha 1d-adrenoceptor: norepinephrine &gt; epinephrine &gt; cirazoline &gt; phenylephrine &gt; oxymetazoline &gt; A-61603 &gt; methoxamine.	Epinephrine	138-149	adrenoceptor alpha 1D	Rattus norvegicus	112-133
8611027-4	1996	Spectroscopic studies indicated NADH:molecular oxygen reductase activity resulted in the production of the superoxide radical, detected as the formation of adrenochrome from epinephrine and by the formation of adrenochrome from epinephrine and by the reduction of nitroblue tetrazolium, both of which could be inhibited by the addition of superoxide dismutase and were unaffected by the addition of catalase.	Epinephrine	174-185	catalase	Homo sapiens	399-407
8611027-4	1996	Spectroscopic studies indicated NADH:molecular oxygen reductase activity resulted in the production of the superoxide radical, detected as the formation of adrenochrome from epinephrine and by the formation of adrenochrome from epinephrine and by the reduction of nitroblue tetrazolium, both of which could be inhibited by the addition of superoxide dismutase and were unaffected by the addition of catalase.	Epinephrine	228-239	catalase	Homo sapiens	399-407
8608229-12	1996	Both TRAP and ADP/epinephrine redistributed platelet surface GPIb, GPIX, and GPV to the SCCS.	Epinephrine	18-29	glycoprotein IX platelet	Homo sapiens	67-71
8654394-7	1996	Similar experiments using several adrenergic agonists revealed that Medaka alpha1A-AR responds to the following agonists in the order: epinephrine &gt; or = (-)norepinephrine &gt; oxymetazoline &gt; or = methoxamine, which is similar to the responses of rat alpha1A receptor expressed in COS cells.	Epinephrine	135-146	adrenoceptor alpha 1A	Homo sapiens	75-85
8821542-4	1996	COMT activity, evaluated by the ability to methylate adrenaline to metanephrine, was determined in liver and kidney homogenates prepared in 0.5 mM phosphate buffer (pH = 7.8) containing pargyline (0.1 mM), MgCl2 (0.1 mM), EGTA (1 mM) and S-adenosyl-L-methionine (0.1 mM).	Epinephrine	53-63	catechol-O-methyltransferase	Rattus norvegicus	0-4
8777469-0	1996	Effects of increased arterial epinephrine on insulin, glucose and phosphate.	Epinephrine	30-41	insulin	Homo sapiens	45-52
8609227-1	1996	Short-term preexposure of mononuclear cells to epinephrine inhibits LPS-induced production of TNF, whereas preexposure for 24 h results in increased TNF production.	Epinephrine	47-58	tumor necrosis factor	Homo sapiens	94-97
8609227-4	1996	In separate in vitro experiments in whole blood, epinephrine increased LPS-induced IL-10 release by a combined effect on alpha and beta adrenergic receptors.	Epinephrine	49-60	interleukin 10	Homo sapiens	83-88
8609227-5	1996	Further, in LPS-stimulated blood, the increase on IL-10 levels caused by epinephrine only marginally contributed to concurrent inhibition of TNF production.	Epinephrine	73-84	interleukin 10	Homo sapiens	50-55
8609227-5	1996	Further, in LPS-stimulated blood, the increase on IL-10 levels caused by epinephrine only marginally contributed to concurrent inhibition of TNF production.	Epinephrine	73-84	tumor necrosis factor	Homo sapiens	141-144
9199118-11	1996	In women working in the CS2 atmosphere, 24-hours excretion of adrenaline is significantly lower (p &lt; 0.001) as compared to the control group.	Epinephrine	62-72	chorionic somatomammotropin hormone 2	Homo sapiens	24-27
8777469-2	1996	In the present study we therefore investigated the effect of raising arterial plasma epinephrine within the lower pathophysiological concentration range on insulin, glucose and phosphate in blood.	Epinephrine	85-96	insulin	Homo sapiens	156-163
8777469-4	1996	Compared with infusion of saline, epinephrine caused a small but significant rise in serum insulin of 10 +/- 26 pmol/L (p = 0.016), more than 70% increase in serum glucose (p &lt; 0.0001) and a decrease in serum phosphate (p &lt; 0.0001).	Epinephrine	34-45	insulin	Homo sapiens	91-98
9162435-5	1996	However, the mental stress caused by announcement of a forthcoming arithmetic stress test increased diastolic blood pressure and plasma epinephrine dependent on insulin resistance (p = 0.006 and p = 0.012, respectively) with a similar trend also for the maximal increases in heart rate and plasma norepinephrine during arithmetic.	Epinephrine	136-147	insulin	Homo sapiens	161-168
8777469-5	1996	The changes in serum insulin during epinephrine infusion correlated negatively with the changes in arterial plasma epinephrine (r = -0.46, p = 0.003) and the changes in serum phosphate correlated negatively with the changes in serum glucose (r = -0.42, p = 0.007).	Epinephrine	36-47	insulin	Homo sapiens	21-28
8777469-5	1996	The changes in serum insulin during epinephrine infusion correlated negatively with the changes in arterial plasma epinephrine (r = -0.46, p = 0.003) and the changes in serum phosphate correlated negatively with the changes in serum glucose (r = -0.42, p = 0.007).	Epinephrine	115-126	insulin	Homo sapiens	21-28
8777469-6	1996	Thus, arterial plasma epinephrine raised within the lower pathophysiological concentration range over a rather short period of time (60 min) has pronounced effects on insulin, glucose and phosphate in blood.	Epinephrine	22-33	insulin	Homo sapiens	167-174
8777469-7	1996	These results suggest that epinephrine when infused acutely may suppress the insulin response to raised glucose, and that the acute hypophosphatemic effect of epinephrine is related to the glucose production.	Epinephrine	27-38	insulin	Homo sapiens	77-84
8777469-8	1996	Thus, when epinephrine is released into the circulation during various forms of daily stress, e.g. mental stress, it may significantly affect insulin and glucose metabolism.	Epinephrine	11-22	insulin	Homo sapiens	142-149
8549185-12	1996	CONCLUSIONS: Epinephrine and isoproterenol are the most efficacious and potent direct-acting beta 2-adrenergic receptor agonists using this lymphocyte cAMP model.	Epinephrine	13-24	adrenoceptor beta 2	Homo sapiens	93-119
8598500-8	1996	These data demonstrate that adrenaline and noradrenaline modulate the migratory capacity of human NK cells via spleen-independent beta 2-adrenoceptor mechanism.	Epinephrine	28-38	adrenoceptor beta 2	Homo sapiens	130-149
8970742-4	1996	Bovine serum albumin, when combined with either enantiomer of epinephrine, produced nonstereoselective alterations of the spectra.	Epinephrine	62-73	albumin	Rattus norvegicus	7-20
8592096-0	1996	Role of epinephrine-induced hypokalemia in the regulation of renin and aldosterone in humans.	Epinephrine	8-19	renin	Homo sapiens	61-66
8592096-1	1996	Circulating epinephrine induces both stimulation of plasma renin activity (PRA) and a decrease in serum potassium concentration.	Epinephrine	12-23	renin	Homo sapiens	59-64
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Epinephrine	119-130	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	45-61
8845008-8	1996	administration of thyrotropin releasing hormone (TRH) (10 nmol/animal) also induced increases in plasma levels of adrenaline and noradrenaline, however, these increases were not modified by i.c.v.	Epinephrine	114-124	thyrotropin releasing hormone	Rattus norvegicus	18-47
8833223-2	1996	The production of PLP from pyridoxal (PL) by pyridoxal kinase (PLK) was inhibited by the addition of dopamine (DA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), but not by that of epinephrine and N-acetyl-serotonin.	Epinephrine	119-130	pyridoxal (pyridoxine, vitamin B6) kinase	Mus musculus	63-66
8825897-1	1995	The principal brain synaptic vesicular monoamine transporter (VMAT2) is responsible for the reuptake of serotonin, dopamine, norepinephrine, epinephrine, and histamine from the cytoplasm into synaptic vesicles, thus contributing to determination of the size of releasable neurotransmitter vesicular pools.	Epinephrine	128-139	solute carrier family 18 member A2	Homo sapiens	62-67
9112626-1	1996	It has been found that dopamine beta-hydroxylase (DBH) (E.C.1.14.17.1), a key enzyme in the multistep process of adrenaline formation, isolated from blood serum by fractionated salting out procedure, is an allosteric enzyme with a sigmoidal kinetics and positive cooperativity in binding of the substrate and effectors.	Epinephrine	113-123	dopamine beta-hydroxylase	Homo sapiens	23-48
9112626-1	1996	It has been found that dopamine beta-hydroxylase (DBH) (E.C.1.14.17.1), a key enzyme in the multistep process of adrenaline formation, isolated from blood serum by fractionated salting out procedure, is an allosteric enzyme with a sigmoidal kinetics and positive cooperativity in binding of the substrate and effectors.	Epinephrine	113-123	dopamine beta-hydroxylase	Homo sapiens	50-53
9112626-3	1996	This noncompetitive inhibitory effect of butobendin was stronger than the feed-back DBH inhibition by adrenaline and noradrenaline or by quinidine used as a standard antiarrhythmic compound.	Epinephrine	102-112	dopamine beta-hydroxylase	Homo sapiens	84-87
7503739-2	1995	We report here that NO at a low micromolar concentration stimulates epinephrine-sensitive insulin secretion from cells of the beta-cell line, INS-1.	Epinephrine	68-79	insulin	Homo sapiens	90-97
8849337-1	1995	This study examined the effects of glycocorticoids, insulin, thyroxine, and epinephrine upon the activities of CuZn- and Mn-superoxide dismutases (SOD), catalase, and glutathione peroxidase (GPX) and upon hydrogen peroxide production in rat macrophages obtained from the intraperitoneal cavity.	Epinephrine	76-87	superoxide dismutase 1	Rattus norvegicus	147-150
8849337-1	1995	This study examined the effects of glycocorticoids, insulin, thyroxine, and epinephrine upon the activities of CuZn- and Mn-superoxide dismutases (SOD), catalase, and glutathione peroxidase (GPX) and upon hydrogen peroxide production in rat macrophages obtained from the intraperitoneal cavity.	Epinephrine	76-87	catalase	Rattus norvegicus	153-161
7503739-2	1995	We report here that NO at a low micromolar concentration stimulates epinephrine-sensitive insulin secretion from cells of the beta-cell line, INS-1.	Epinephrine	68-79	forkhead box M1	Homo sapiens	142-147
8548058-3	1995	Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance.	Epinephrine	76-87	galanin and GMAP prepropeptide	Homo sapiens	6-9
8548058-3	1995	Human GAL administration significantly reduced both the release of basal norepinephrine and the response to insulin-induced hypoglycemia, whereas it attenuated the epinephrine response by 26%, with the hGAL-induced decrease in epinephrine release failing to achieve statistical significance.	Epinephrine	164-175	galanin and GMAP prepropeptide	Homo sapiens	202-206
7486158-2	1995	Studies have identified the epinephrine metabolizing enzyme, catechol-O-methyl transferase (COMT), in the cranial meninges of several species.	Epinephrine	28-39	catechol-O-methyltransferase	Sus scrofa	61-90
7594512-5	1995	Low dose, but not high dose, TNFR:Fc blunted or delayed the release of epinephrine and cortisol (p &lt; or = 0.026).	Epinephrine	71-82	TNF receptor superfamily member 1A	Homo sapiens	29-33
7592956-4	1995	Expressed mutants of hhG alpha h with deleted C-terminal regions lost the response to (-)-epinephrine and GTP and failed to coimmunoprecipitate PLC by the specific Gh7 alpha antibody.	Epinephrine	86-101	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	21-24
7486158-2	1995	Studies have identified the epinephrine metabolizing enzyme, catechol-O-methyl transferase (COMT), in the cranial meninges of several species.	Epinephrine	28-39	catechol-O-methyltransferase	Sus scrofa	92-96
7486158-10	1995	CONCLUSIONS: These data demonstrate the functional presence of COMT in the spinal meninges of pigs and monkeys and suggest that the spinal meninges may limit the spinal bioavailability of epidurally or intrathecally administered epinephrine.	Epinephrine	229-240	catechol-O-methyltransferase	Sus scrofa	63-67
7593632-8	1995	When compared to the control cell extract, the epinephrine-treated cell extract sharply inhibited LPL translation in vitro, yet had no effect on the translation of other mRNAs.	Epinephrine	47-58	lipoprotein lipase	Mus musculus	98-101
7593632-5	1995	Epinephrine induced a dose-dependent decrease in LPL synthesis using [35S]methionine incorporation, with no change in LPL mRNA levels, demonstrating translational regulation of LPL in this cell line.	Epinephrine	0-11	lipoprotein lipase	Mus musculus	49-52
7593632-13	1995	Thus, epinephrine-treated adipocytes produced a transacting factor, probably a protein, that interacted with a region on the LPL mRNA between nucleotides 1599 and 1638, resulting in an inhibition of translation.	Epinephrine	6-17	lipoprotein lipase	Mus musculus	125-128
7593645-9	1995	Epinephrine infusion, which increased plasma epinephrine to levels observed during hypoglycemia (3722 +/- 453 pmol/liter) increased renal glucose release nearly twofold (5.2 +/- 0.5 vs 2.8 +/- 0.1 mol.kg-1.min-1, P = 0.01) so that at the end of the infusion, renal glucose release accounted for 40.3 +/- 5.5% of systemic glucose appearance and essentially all of the increase in systemic glucose appearance.	Epinephrine	0-11	CD59 molecule (CD59 blood group)	Homo sapiens	206-211
8541436-16	1995	This concept avoids overdosage in patients who had just collapsed shortly before initiation of CPR, attains higher levels of epinephrine in patients suffering from prolonged cardiac arrest, and takes into consideration that the effective epinephrine dose varies individually and increases with prolongation of the cardiac arrest interval.	Epinephrine	238-249	cytochrome p450 oxidoreductase	Homo sapiens	95-98
8697051-7	1995	The relative order of affinity of the various fat cell ARs for the physiological amines defined in binding studies and in vitro assays is alpha 2 &gt; beta 1 &gt; or = beta 2 &gt; beta 3 for norepinephrine and alpha 2 &gt; beta 2 &gt; beta 1 &gt; beta 3 for epinephrine.	Epinephrine	194-205	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	180-186
8595522-10	1995	In contrast, TNF-alpha administration markedly increased plasma levels of PGE2 and epinephrine.	Epinephrine	83-94	tumor necrosis factor	Rattus norvegicus	13-22
8595522-11	1995	Thus, the elevated Kupffer cell cAMP levels induced by TNF-alpha are not due to upregulation of beta-adrenergic receptors, but may be associated with the elevated levels of circulating PGE2 and/or epinephrine.	Epinephrine	197-208	cathelicidin antimicrobial peptide	Rattus norvegicus	32-36
8595522-11	1995	Thus, the elevated Kupffer cell cAMP levels induced by TNF-alpha are not due to upregulation of beta-adrenergic receptors, but may be associated with the elevated levels of circulating PGE2 and/or epinephrine.	Epinephrine	197-208	tumor necrosis factor	Rattus norvegicus	55-64
7572705-6	1995	Each subject was studied in the basal state and during a 1-h infusion of epinephrine (0.015 microgram kg(-1 min(-1) after 84 h of total energy restriction and after 84 h of carbohydrate restriction (12 h after the final lipid infusion).	Epinephrine	73-84	CD59 molecule (CD59 blood group)	Homo sapiens	108-114
7590139-2	1995	Isolated human platelets were used to investigate the effect of atrial natriuretic peptide (ANP) on in vitro platelet aggregation induced by epinephrine, ADP, collagen and 5-hydroxytryptamine.	Epinephrine	141-152	natriuretic peptide A	Homo sapiens	64-90
21153166-3	1995	The results demonstrate a decrease in insulin-stimulated receptor and IRS-1 phosphorylation levels which was accompanied by a reduction in the association of IRS-1 with PI 3-kinasein vivo in liver and muscle of epinephrine treated rats.	Epinephrine	211-222	insulin receptor substrate 1	Rattus norvegicus	70-75
21153166-3	1995	The results demonstrate a decrease in insulin-stimulated receptor and IRS-1 phosphorylation levels which was accompanied by a reduction in the association of IRS-1 with PI 3-kinasein vivo in liver and muscle of epinephrine treated rats.	Epinephrine	211-222	insulin receptor substrate 1	Rattus norvegicus	158-163
7590139-2	1995	Isolated human platelets were used to investigate the effect of atrial natriuretic peptide (ANP) on in vitro platelet aggregation induced by epinephrine, ADP, collagen and 5-hydroxytryptamine.	Epinephrine	141-152	natriuretic peptide A	Homo sapiens	92-95
7590139-5	1995	In our experiments ANP inhibited epinephrine- and partially ADP-induced aggregation in vitro and this effect was suggested to be the result of an interaction of the peptide with adenylate cyclase in platelets.	Epinephrine	33-44	natriuretic peptide A	Homo sapiens	19-22
8568924-0	1995	Norepinephrine but not epinephrine stimulates the release of corticotropin-releasing factor from in vitro superfused rat hypothalamus.	Epinephrine	3-14	corticotropin releasing hormone	Rattus norvegicus	61-91
8578535-4	1995	A dose-dependent enhancement of the aggregation response to epinephrine was noted in MGDF treated platelets.	Epinephrine	60-71	thrombopoietin	Homo sapiens	85-89
7476289-1	1995	Infusion of epinephrine and norepinephrine reduces insulin-mediated glucose disposal, ie, induces insulin resistance.	Epinephrine	12-23	insulin	Homo sapiens	51-58
7476289-1	1995	Infusion of epinephrine and norepinephrine reduces insulin-mediated glucose disposal, ie, induces insulin resistance.	Epinephrine	12-23	insulin	Homo sapiens	98-105
8565785-5	1995	Monoamine neurotransmittors, such as epinephrine and dopamine, were maximally conjugated at lower concentrations by expressed hM-PST (2 and 20 microM, respectively) than by hP-PST (1 and 1 mM, respectively).	Epinephrine	37-48	mercaptopyruvate sulfurtransferase	Homo sapiens	126-132
7654215-2	1995	Adrenaline has recently been shown to stimulate both glucose metabolism and H2O2 release by macrophages but the activity of the key pentose phosphate pathway enzyme, glucose-6-phosphate dehydrogenase (which generates the NADPH crucial for the reduction of molecular oxygen), was reduced under these conditions [Costa Rosa, Safi, Cury and Curi (1992) Biochem.	Epinephrine	0-10	glucose-6-phosphate dehydrogenase	Homo sapiens	166-199
7654215-5	1995	We report here that adrenaline activates another NADPH-producing enzyme, NADP(+)-dependent "malic" enzyme, while also inhibiting glucose-6-phosphate dehydrogenase, via cyclic AMP-dependent protein kinase (PKA) activation.	Epinephrine	20-30	glucose-6-phosphate dehydrogenase	Homo sapiens	129-162
8564231-6	1995	Adrenaline decreased not only the production of cyclic AMP but also that of cyclic GMP.	Epinephrine	0-10	5'-nucleotidase, cytosolic II	Homo sapiens	83-86
8564231-13	1995	We also propose that reduction of both cyclic AMP and cyclic GMP are involved in adrenaline-induced platelet aggregation.	Epinephrine	81-91	5'-nucleotidase, cytosolic II	Homo sapiens	61-64
7669252-1	1995	The beta 2 adrenergic receptor (beta 2AR) plays a key role in the signal transduction mechanism for epinephrine and norepinephrine.	Epinephrine	100-111	adrenoceptor beta 2	Macaca mulatta	4-30
7669252-1	1995	The beta 2 adrenergic receptor (beta 2AR) plays a key role in the signal transduction mechanism for epinephrine and norepinephrine.	Epinephrine	100-111	adrenoceptor beta 2	Macaca mulatta	32-40
8565785-5	1995	Monoamine neurotransmittors, such as epinephrine and dopamine, were maximally conjugated at lower concentrations by expressed hM-PST (2 and 20 microM, respectively) than by hP-PST (1 and 1 mM, respectively).	Epinephrine	37-48	sulfotransferase family 1A member 1	Homo sapiens	173-191
8542857-8	1995	This lack of a hypokalaemic effect might be partly due to reduced responsiveness of beta 2-adrenoceptors to adrenaline.	Epinephrine	108-118	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	84-90
7795224-6	1995	Subthreshold concentrations of Sph-1-P and weak platelet agonists such as adenosine diphosphate (ADP) and epinephrine synergistically elicited aggregation, which may be important for efficient amplification of platelet activation.	Epinephrine	106-117	ankyrin 1	Homo sapiens	31-36
7666200-10	1995	In the CNS, dopamine, norepinephrine, epinephrine, 5-HT, and histamine cell groups all express VMAT2.	Epinephrine	25-36	solute carrier family 18 member A2	Rattus norvegicus	95-100
7646058-1	1995	Alcohol dehydrogenase (ADH) is enhanced separately by epinephrine and by glucagon in primary rat hepatocyte culture.	Epinephrine	54-65	aldo-keto reductase family 1 member A1	Rattus norvegicus	0-21
7646058-1	1995	Alcohol dehydrogenase (ADH) is enhanced separately by epinephrine and by glucagon in primary rat hepatocyte culture.	Epinephrine	54-65	aldo-keto reductase family 1 member A1	Rattus norvegicus	23-26
7646058-8	1995	The previously demonstrated induction of ADH by epinephrine and glucagon may be mediated by a common pathway via an increase in cyclic AMP.	Epinephrine	48-59	aldo-keto reductase family 1 member A1	Rattus norvegicus	41-44
7542495-4	1995	Both P-selectin-positive and -negative animals displayed similar increases in peripheral blood neutrophil numbers after injection of epinephrine.	Epinephrine	133-144	selectin, platelet	Mus musculus	5-15
7616202-2	1995	We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype.	Epinephrine	214-225	phenylethanolamine-N-methyltransferase	Mus musculus	51-89
7616202-2	1995	We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype.	Epinephrine	214-225	phenylethanolamine-N-methyltransferase	Mus musculus	91-95
7616202-2	1995	We previously generated transgenic mice expressing phenylethanolamine N-methyltransferase (PNMT) under the control of a human dopamine beta-hydroxylase gene promoter to switch catecholamine specificity from the norepinephrine phenotype to the epinephrine phenotype.	Epinephrine	214-225	dopamine beta-hydroxylase	Homo sapiens	126-151
7616202-4	1995	In the transgenic target tissues, a high-level expression of PNMT led to a dramatic increase in the epinephrine levels, whereas the norepinephrine levels were decreased to 48.6-87.9% of the nontransgenic control levels.	Epinephrine	100-111	phenylethanolamine-N-methyltransferase	Mus musculus	61-65
7586573-4	1995	Increase of adrenal N-methyladrenaline content follows endocrine maturation of the medulla, phenylethanolamine-N-methyltransferase induction and subsequent adrenaline synthesis.	Epinephrine	28-38	phenylethanolamine N-methyltransferase	Homo sapiens	92-130
8568627-4	1995	All the compounds tested in human PRP showed significant inhibition of secondary aggregation induced by adrenaline, suggesting that the antiplatelet effects of these compounds is mainly due to an inhibitory effect on thromboxane formation.	Epinephrine	104-114	complement component 4 binding protein alpha	Homo sapiens	34-37
8948900-0	1995	[Effect of adrenaline on food consumption and C-fos expression in the central nervous system].	Epinephrine	11-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
7797738-11	1995	Epinephrine at the low dose enhanced mitogen-induced proliferation and interleukin-2 receptor expression.	Epinephrine	0-11	interleukin 2	Homo sapiens	71-84
7542030-5	1995	The response seen with a maximally effective concentration of amylin (10 nM) was similar to that seen with a maximally effective concentration of epinephrine (1 microM) under the same conditions.	Epinephrine	146-157	islet amyloid polypeptide	Rattus norvegicus	62-68
8524696-6	1995	Platelet aggregation (in PRP according to Born) induced by collagen (2 micrograms/ml), ADP (5 microM), epinephrine (10 microM) arachidonic acid (0.25 mM) and 5-HT (1 microM) was found to be significantly enhanced in diabetic relative to controls.	Epinephrine	103-114	prion protein	Homo sapiens	25-28
7755201-1	1995	STUDY OBJECTIVE: To describe a case series of emergency medical technician-basic (EMT-B)-administered epinephrine for anaphylaxis in a wilderness setting.	Epinephrine	102-113	IL2 inducible T cell kinase	Homo sapiens	82-85
7755201-2	1995	DESIGN: Case series of patients in anaphylaxis who received epinephrine subcutaneously from EMT-Bs.	Epinephrine	60-71	IL2 inducible T cell kinase	Homo sapiens	92-95
7793657-3	1995	Another alpha 1 subtype (alpha 1A), sensitive to the competitive antagonist WB4101, increases spontaneous rate and action potential duration by a mechanism thought to involve hydrolysis of membrane phosphoinositides by phospholipase C. This study examined the dose-response relation and receptor-effector mechanisms underlying depression of conduction in canine Purkinje fibers by epinephrine with halothane.	Epinephrine	381-392	adrenoceptor alpha 1A	Canis lupus familiaris	25-33
7793657-9	1995	WB4101 (0.1 microM) produced 87% inhibition of the response to 0.2 microM epinephrine after chloroethylclonidine pretreatment, indicating mediation by the alpha 1A subtype.	Epinephrine	74-85	adrenoceptor alpha 1A	Canis lupus familiaris	155-163
7755201-6	1995	INTERVENTION: Subcutaneous administration of epinephrine by EMT-Bs trained in recognition, understanding, and treatment of anaphylaxis.	Epinephrine	45-56	IL2 inducible T cell kinase	Homo sapiens	60-63
7793657-11	1995	CONCLUSIONS: Clinically relevant concentrations of epinephrine transiently depress conduction in Purkinje fibers exposed to halothane by activating cardiac alpha 1 adrenoceptors, largely but not exclusively the WB4101-sensitive alpha 1A subtype, reportedly coupled to stimulation of phospholipase C and generation of the second messengers diacylglycerol and inositol trisphosphate.	Epinephrine	51-62	adrenoceptor alpha 1A	Canis lupus familiaris	228-236
7755201-7	1995	RESULTS: Eight patients with anaphylaxis resulting from Hymenoptera stings, from June 1992 through September 1993, received EMT-B-administered epinephrine.	Epinephrine	143-154	IL2 inducible T cell kinase	Homo sapiens	124-127
7755201-10	1995	CONCLUSION: Our data suggest that EMT-B-administered epinephrine is safe when used by EMT-Bs in the rural/wilderness setting, with appropriate physician supervision.	Epinephrine	53-64	IL2 inducible T cell kinase	Homo sapiens	34-37
7755201-10	1995	CONCLUSION: Our data suggest that EMT-B-administered epinephrine is safe when used by EMT-Bs in the rural/wilderness setting, with appropriate physician supervision.	Epinephrine	53-64	IL2 inducible T cell kinase	Homo sapiens	86-89
21153248-0	1995	Prolonged infusion of epinephrine down-regulates expression of the fatty acid synthase gene in adipocytes.	Epinephrine	22-33	fatty acid synthase	Rattus norvegicus	67-86
21153248-6	1995	The infusion of epinephrine down-regulated expression of the fatty acid synthase mRNA as well as decreasing enzyme activity.	Epinephrine	16-27	fatty acid synthase	Rattus norvegicus	61-80
21153248-7	1995	Both epinephrine and isoproterenol inhibited fatty acid synthase mRNA expression when adipocytes were activatedin vitro.	Epinephrine	5-16	fatty acid synthase	Rattus norvegicus	45-64
7539818-3	1995	hGAL depressed supine plasma NE (0.84 +/- 0.06 vs. 0.33 +/- 0.02 nmol/L) and blunted the NE response to assumption of the UP (1.68 +/- 0.03 vs. 0.44 +/- 0.03 nmol/L), but caused a significant enhancement of the epinephrine response to assumption of the UP (0.22 +/- 0.02 vs. 0.65 +/- 0.06 nmol/L).	Epinephrine	211-222	galanin and GMAP prepropeptide	Homo sapiens	0-4
7662225-10	1995	beta 2-adrenoceptor density correlated with plasma epinephrine levels in the control group (r = -0.50, P &lt; .01), but not in hypertensive patients before treatment.	Epinephrine	51-62	adrenoceptor beta 2	Homo sapiens	0-19
7783654-6	1995	This was confirmed by multiple regression analysis, which also showed a positive correlation of LPL activity with aortic flow velocity and plasma adrenaline (F significance = 0.0007, R2 = .905).	Epinephrine	146-156	lipoprotein lipase	Homo sapiens	96-99
7783654-9	1995	A positive correlation was found between LPL and adrenaline changes induced by the combined treatment.	Epinephrine	49-59	lipoprotein lipase	Homo sapiens	41-44
7741112-4	1995	This study examines the capacity of anti-PlAl from patients with PTP and from mothers of infants affected by the NAIT to block the binding of radio-labeled fibrinogen to washed human platelets stimulated by ADP and epinephrine.	Epinephrine	215-226	fibrinogen beta chain	Homo sapiens	156-166
7625922-10	1995	EPO treatment induced a significant decrease in somatotropin, prolactin, follitropin, lutropin, ACTH, cortisol, plasma renin activity, aldosterone, noradrenaline, adrenaline, dopamine, glucagon, pancreatic polypeptide, and gastrin plasma levels and an increase in plasma insulin, estradiol, testosterone, atrial natriuretic peptide, thyrotropin, and thyroxine.	Epinephrine	151-161	erythropoietin	Homo sapiens	0-3
7670725-14	1995	ET-1 (1 nmol kg-1)-induced neutropenia was prevented by pretreatment of the animals with FR 139317 (2.5 mg kg-1), bosentan (10 mg kg-1) or adrenaline (90 nmol kg-1), indicating that ET-1 caused intravascular sequestration of neutrophil granulocytes.	Epinephrine	139-149	endothelin-1	Cavia porcellus	0-4
7621895-1	1995	The beta 3-adrenoceptor is a G protein-coupled receptor which mediates metabolic functions of the endogenous catecholamines epinephrine and norepinephrine.	Epinephrine	124-135	adrenoceptor beta 3	Homo sapiens	4-23
7482413-0	1995	Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats.	Epinephrine	58-69	plasminogen activator, tissue type	Rattus norvegicus	41-45
7482413-4	1995	Five min epinephrine (EPI) infusion (0.15-25 microM) induced a dose-dependent increase in tissue-type plasminogen activator (t-PA) release and in perfusion pressure, in both young and aged rats.	Epinephrine	9-20	plasminogen activator, tissue type	Rattus norvegicus	90-123
7482413-4	1995	Five min epinephrine (EPI) infusion (0.15-25 microM) induced a dose-dependent increase in tissue-type plasminogen activator (t-PA) release and in perfusion pressure, in both young and aged rats.	Epinephrine	9-20	plasminogen activator, tissue type	Rattus norvegicus	125-129
7482413-4	1995	Five min epinephrine (EPI) infusion (0.15-25 microM) induced a dose-dependent increase in tissue-type plasminogen activator (t-PA) release and in perfusion pressure, in both young and aged rats.	Epinephrine	22-25	plasminogen activator, tissue type	Rattus norvegicus	90-123
7482413-4	1995	Five min epinephrine (EPI) infusion (0.15-25 microM) induced a dose-dependent increase in tissue-type plasminogen activator (t-PA) release and in perfusion pressure, in both young and aged rats.	Epinephrine	22-25	plasminogen activator, tissue type	Rattus norvegicus	125-129
7721191-3	1995	Midaglizole reversed epinephrine-induced inhibition of insulin release and reduction of cAMP levels, as did yohimbine.	Epinephrine	21-32	cathelicidin antimicrobial peptide	Rattus norvegicus	88-92
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Epinephrine	220-231	adenylate cyclase activating polypeptide 1	Rattus norvegicus	5-10
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Epinephrine	220-231	adenylate cyclase activating polypeptide 1	Rattus norvegicus	18-23
7624029-4	1995	Both PACAP 27 and PACAP 38 are able to stimulate proliferation of adult rat chromaffin cells in vitro, either alone or in conjunction with PMA, an activator of protein kinase C. BrdU-labelled nuclei are observed in both epinephrine and norepinephrine cells, and proliferation of both cell types is stimulated by the same concentrations of PACAP that elicit secretion of catecholamines.	Epinephrine	220-231	adenylate cyclase activating polypeptide 1	Rattus norvegicus	18-23
7733399-4	1995	In this study, we investigated the direct effect of epinephrine (another stress hormone) on the production of TNF and IL-6 in liver.	Epinephrine	52-63	interleukin 6	Rattus norvegicus	118-122
7733399-5	1995	We demonstrated that epinephrine (1 microM/ml) alone did not induce TNF bioactivity but significantly increased IL-6 bioactivity from IPRL effluent.	Epinephrine	21-32	interleukin 6	Rattus norvegicus	112-116
7733399-6	1995	When the IPRL was infused with LPS, epinephrine significantly decreased TNF bioactivity.	Epinephrine	36-47	tumor necrosis factor-like	Rattus norvegicus	72-75
7733399-7	1995	Epinephrine in LPS-treated livers also significantly increased IL-6 bioactivity.	Epinephrine	0-11	interleukin 6	Rattus norvegicus	63-67
7733399-11	1995	Using isolated Kupffer cells and hepatocytes, we found that epinephrine alone had no effect on TNF and IL-6 production in Kupffer cells and hepatocytes but significantly decreased LPS-induced TNF bioactivity and increased LPS-induced IL-6 bioactivity in Kupffer cells.	Epinephrine	60-71	tumor necrosis factor-like	Rattus norvegicus	192-195
7733399-11	1995	Using isolated Kupffer cells and hepatocytes, we found that epinephrine alone had no effect on TNF and IL-6 production in Kupffer cells and hepatocytes but significantly decreased LPS-induced TNF bioactivity and increased LPS-induced IL-6 bioactivity in Kupffer cells.	Epinephrine	60-71	interleukin 6	Rattus norvegicus	234-238
7733399-12	1995	Our data support the hypothesis that epinephrine can promote IL-6 secretion from IPRL.	Epinephrine	37-48	interleukin 6	Rattus norvegicus	61-65
7541688-14	1995	Addition of adrenaline (5 mM) and glutathione (0.1 mM) increased the activity of COX-2 in broken cell preparations.	Epinephrine	12-22	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	81-86
8590916-12	1995	Two antioxidant enzymes, superoxide dismutase and catalase, inhibited the epinephrine-induced damage to DNA.	Epinephrine	74-85	catalase	Homo sapiens	50-58
7736695-2	1995	We tested the effect of intravenous adrenaline at 0.55-1.10 nmol min-1 kg-1 (for 3-8 min, at 7-10 min post bypass; n = 7) on both microaggregation in hirudinized whole blood, using platelet counting, and macroaggregation in platelet-rich plasma, using optical aggregometry.	Epinephrine	36-46	CD59 molecule (CD59 blood group)	Homo sapiens	65-75
7733399-0	1995	Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver.	Epinephrine	8-19	tumor necrosis factor-like	Rattus norvegicus	23-26
7733399-4	1995	In this study, we investigated the direct effect of epinephrine (another stress hormone) on the production of TNF and IL-6 in liver.	Epinephrine	52-63	tumor necrosis factor-like	Rattus norvegicus	110-113
7891085-4	1995	The selective beta-adrenergic agonist isoproterenol (1-100 microM) and epinephrine (1-100 microM) each reduced peak Kir current amplitudes to 52.7 +/- 12.5 and 63.6 +/- 7.0%, respectively, at 100 microM.	Epinephrine	71-82	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	116-119
8935187-9	1995	Epinephrine and ADP induced aggregation was inhibited in concentrations higher than 30 micrograms/ml PRP.	Epinephrine	0-11	proline rich protein 2-like 1	Rattus norvegicus	101-104
7867193-10	1995	Several pathophysiologically relevant factors also augmented IL-6 release from cultured cardiac myocytes, including IL-1 beta, ionomycin, and epinephrine.	Epinephrine	142-153	interleukin 6	Rattus norvegicus	61-65
7876081-1	1995	Epinephrine stimulation of rat alpha 2D, alpha 2B, and alpha 2C adrenergic receptor subtypes, expressed stably in Chinese hamster ovary (CHO) cells, caused a rapid, transient activation of mitogen-activated protein kinase (MAPK), with subtype-specific different efficiencies.	Epinephrine	0-11	adrenoceptor alpha 2C	Rattus norvegicus	55-83
7588387-10	1995	Both IL-1 alpha and IL-1 beta significantly elevated (P &lt; 0.05) epinephrine levels after a 24 hr incubation period compared to media-treated controls.	Epinephrine	67-78	interleukin 1 alpha	Rattus norvegicus	5-15
7588387-10	1995	Both IL-1 alpha and IL-1 beta significantly elevated (P &lt; 0.05) epinephrine levels after a 24 hr incubation period compared to media-treated controls.	Epinephrine	67-78	interleukin 1 beta	Rattus norvegicus	20-29
7840182-2	1995	Its specific action on muscle protein is not known and is difficult to assess during systemic epinephrine infusions, which affect plasma insulin, amino acid, and free fatty acid concentrations.	Epinephrine	94-105	insulin	Homo sapiens	137-144
7756634-2	1995	Microinjections of NPY and l-adrenaline alone into the NTS induced neuronal c-Fos IR in parts of the NTS-dmnX complex, while clonidine had no action.	Epinephrine	27-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-81
7756634-4	1995	Coinjections of NPY and l-adrenaline or clonidine into the NTS reduced the NPY-induced increase in c-Fos IR.	Epinephrine	24-36	neuropeptide Y	Rattus norvegicus	75-78
7756634-4	1995	Coinjections of NPY and l-adrenaline or clonidine into the NTS reduced the NPY-induced increase in c-Fos IR.	Epinephrine	24-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104
7792747-1	1995	In a suspension of thrombin degranulated platelets (TDP), ADP and epinephrine can induce platelet aggregation, whereas the synthetic agonist of the thromboxane/endoperoxide receptor U46619 causes only shape change.	Epinephrine	66-77	coagulation factor II, thrombin	Homo sapiens	19-27
7792747-3	1995	In this paper, we have measured fibrinogen binding in relation to phospholipase C (PLC) activation and calcium mobilization in TDP activates by ADP, epinephrine and U46619.	Epinephrine	149-160	fibrinogen beta chain	Homo sapiens	32-42
7530955-5	1995	HEL membranes also bound [3H]idazoxan in the presence of adrenaline to block alpha 2-adrenoceptors.	Epinephrine	57-67	adrenoceptor alpha 2A	Homo sapiens	77-98
7840338-4	1995	The catecholamine output from the adrenal glands in the sham group significantly increased (P &lt; 0.05), reaching a maximum level 45 min after insulin injection from a control value for epinephrine of 86.35 +/- 26.65 ng/min and for norepinephrine of 32.14 +/- 11.68 ng/min to 659.03 +/- 269.39 and 181.21 +/- 63.03 ng/min, respectively.	Epinephrine	187-198	insulin	Canis lupus familiaris	144-151
7698043-6	1995	RESULTS: In IDDM patients, HbA1 levels were positively correlated with incremental epinephrine (r = 0.58, P &lt; 0.001) and cortisol (r = 0.52, P &lt; 0.01) responses, but inversely correlated with GH responses (r = -0.31, P &lt; 0.05).	Epinephrine	83-94	hemoglobin subunit alpha 1	Homo sapiens	27-31
7698043-8	1995	In IDDM patients with HbA1 &lt; or = 7.8% (n = 7), the epinephrine, cortisol, and symptomatic responses to hypoglycemia were blunted, but GH secretion was preserved.	Epinephrine	55-66	hemoglobin subunit alpha 1	Homo sapiens	22-26
7698043-9	1995	CONCLUSIONS: These data suggest that 1) there is differential regulation of counterregulatory hormone secretion that is dependent on the level of glycemic control, 2) epinephrine is an important determinant of symptom perception in IDDM patients, but not in healthy control subjects, and 3) multiple defects in counterregulatory hormone secretion and symptom perception are consistently observed in patients with HbA1 levels &lt; or = 7.8%.	Epinephrine	167-178	hemoglobin subunit alpha 1	Homo sapiens	413-417
7729444-1	1995	Adrenaline infusion of 0.1 microgram.kg-1.min-1 in healthy volunteers results in an increase of hepatic glucose production, an increase of the absolute number of occupied beta-adrenoceptors and specific changes in metabolism.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	42-47
12114814-16	1995	The phenotype of pheochromocytomas in mice with the Nf1(31) mutation resembles that of human pheochromocytomas, particularly with respect to their ability to produce epinephrine, as inferred from positive staining for PNMT.	Epinephrine	166-177	neurofibromin 1	Mus musculus	52-55
7854166-3	1995	During insulin clamping, plasma adrenaline increased significantly in controls, but not in SCI subjects.	Epinephrine	32-42	insulin	Homo sapiens	7-14
7628838-1	1995	Catecholamines (adrenaline and noradrenaline) stimulate adipocyte lipolysis via three beta-adrenoceptor subtypes beta 1, beta 2 and beta 3.	Epinephrine	16-26	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	113-119
7628838-1	1995	Catecholamines (adrenaline and noradrenaline) stimulate adipocyte lipolysis via three beta-adrenoceptor subtypes beta 1, beta 2 and beta 3.	Epinephrine	16-26	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	121-138
8788067-1	1995	GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively.	Epinephrine	253-263	GTP cyclohydrolase 1	Mus musculus	0-20
8788067-1	1995	GTP cyclohydrolase I (GCH) is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin (BH4), the cofactor of phenylalanine, tyrosine, and tryptophan hydroxylases, the enzymes that synthesize tyrosine, catecholamines (dopamine, noradrenaline, and adrenaline), and serotonin, respectively.	Epinephrine	253-263	GTP cyclohydrolase 1	Mus musculus	22-25
7730990-13	1995	injection of CCK increased the concentrations in the dialysate of noradrenaline and serotonin, but not of either adrenaline or dopamine.	Epinephrine	69-79	cholecystokinin	Rattus norvegicus	13-16
8728769-2	1995	Inactivation of lipoamide dehydrogenase (LipDH) by the Cu(II)/H2O2 Fenton system (SF-Cu(II): (5.0 microM Cu(II), 3.0 mM H2O2) was enhanced by catecholamines (CAs), namely, epinephrine, levoDOPA (DOPA), DOPAMINE, 6-hydroxyDOPAMINE (OH-DOPAMINE) and related compounds (DOPAC, CATECHOL, etc.).	Epinephrine	172-183	dihydrolipoamide dehydrogenase	Homo sapiens	16-39
7731501-1	1995	It is well known that the adrenal medulla contains high concentrations of neuropeptide Y (NPY) where it coexists with epinephrine and norepinephrine.	Epinephrine	118-129	neuropeptide Y	Rattus norvegicus	74-88
7731501-1	1995	It is well known that the adrenal medulla contains high concentrations of neuropeptide Y (NPY) where it coexists with epinephrine and norepinephrine.	Epinephrine	118-129	neuropeptide Y	Rattus norvegicus	90-93
7716464-6	1995	The cardiodepressant effect of plain lidocaine was only reversed by the higher adrenaline dose, which however induced a small fall in PD, R and PM.	Epinephrine	79-89	surfactant protein D	Rattus norvegicus	134-136
7878073-9	1994	TH mRNA and TH activity in the adrenal glands were increased in the 3 cold-treated groups and these measures were correlated directly and significantly with plasma norepinephrine and epinephrine concentrations.	Epinephrine	167-178	tyrosine hydroxylase	Rattus norvegicus	0-2
7698202-3	1994	In contrast, in the competition experiments, the neuropeptide Y Y1 and the neuropeptide Y Y2 receptor agonists decreased and increased, respectively, with the same potency the IC50 value of l-adrenaline and especially of clonidine for the alpha 2-adrenoceptor agonist binding sites associated with an increase and a decrease of the B0 value, respectively.	Epinephrine	190-202	neuropeptide Y receptor Y2	Rattus norvegicus	75-101
7889286-15	1994	After blockade of the P2-adrenoceptors on NK cells by pretreatment with GR81706 (10-6 M), the effect of adrenaline on NK cells adhesion was pretented; after blockade of the beta2-adrenoceptors on EC, NK cell adhesion was still significantly reduced by adrenaline.	Epinephrine	104-114	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	173-178
8788067-4	1995	Using this antibody specific for GCH, we observed strong GCH immunostaining in the liver cells, in the dopamine-, noradrenaline-, adrenaline-, or serotonin-containing cells of the brain, and in the adrenal gland of mice.	Epinephrine	117-127	GTP cyclohydrolase 1	Mus musculus	33-36
7999001-9	1994	Thermolytic phosphopeptide mapping of 32P-labelled phospholemman from rat diaphragms shows that treatment with insulin results in labelling of phosphopeptides containing both Ser-63 and Ser-68, whereas treatment with adrenaline results in labelling of the phosphopeptide containing Ser-68.	Epinephrine	217-227	FXYD domain-containing ion transport regulator 1	Rattus norvegicus	51-64
7886022-3	1994	Inhibin and hCG secretion were stimulated by dexamethasone (0.2 microM), GnRH (5-25 microM), calcium ionophore A23187 (0.2-1 microM), phorbol-12-myristate-13-acetate (22 nM) and epinephrine (1 microM), with increasing response over successive 24-h treatment periods.	Epinephrine	178-189	chorionic gonadotropin subunit beta 5	Homo sapiens	12-15
7858855-12	1994	The release of all three eicosanoids in response to ET-1 and adrenaline (Ad) was significantly reduced by indomethacin and the accompanying increases in the splenic arterial vascular resistance were significantly potentiated at low doses of ET-1.	Epinephrine	61-71	endothelin 1	Canis lupus familiaris	241-245
7986204-5	1994	This relatively small increase in PNMT was reflected in the catecholamine levels in that the total epinephrine (EPI) was elevated by only 16% while norepinephrine (NE) was elevated by 99%, which caused a shift in the molar ratio of EPI to NE from 7.0 in the untreated control to 4.1 after forskolin treatment.	Epinephrine	99-110	phenylethanolamine N-methyltransferase	Bos taurus	34-38
7986204-5	1994	This relatively small increase in PNMT was reflected in the catecholamine levels in that the total epinephrine (EPI) was elevated by only 16% while norepinephrine (NE) was elevated by 99%, which caused a shift in the molar ratio of EPI to NE from 7.0 in the untreated control to 4.1 after forskolin treatment.	Epinephrine	112-115	phenylethanolamine N-methyltransferase	Bos taurus	34-38
7858855-12	1994	The release of all three eicosanoids in response to ET-1 and adrenaline (Ad) was significantly reduced by indomethacin and the accompanying increases in the splenic arterial vascular resistance were significantly potentiated at low doses of ET-1.	Epinephrine	73-75	endothelin 1	Canis lupus familiaris	52-56
7858855-12	1994	The release of all three eicosanoids in response to ET-1 and adrenaline (Ad) was significantly reduced by indomethacin and the accompanying increases in the splenic arterial vascular resistance were significantly potentiated at low doses of ET-1.	Epinephrine	73-75	endothelin 1	Canis lupus familiaris	241-245
7813592-6	1994	Cardiovascular analysis demonstrated that a threshold dose of angiotensin II (0.05 pmol) counteracted the vasodepressor effect produced by an ED50 dose of l-adrenaline, l-noradrenaline or clonidine coinjected in the nucleus tractus solitarii.	Epinephrine	155-167	angiotensinogen	Rattus norvegicus	62-76
7525897-1	1994	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine.	Epinephrine	75-86	dopamine beta-hydroxylase	Rattus norvegicus	0-25
7525897-1	1994	Dopamine beta-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine, and is expressed specifically in neurons and neuroendocrine cells that release norepinephrine and epinephrine.	Epinephrine	75-86	dopamine beta-hydroxylase	Rattus norvegicus	27-30
7532621-1	1994	A subline of rat C6 glioma cells, C6-10A cells, in which epinephrine can induce nerve growth factor (NGF) synthesis/secretion, was isolated.	Epinephrine	57-68	nerve growth factor	Rattus norvegicus	80-99
7532621-1	1994	A subline of rat C6 glioma cells, C6-10A cells, in which epinephrine can induce nerve growth factor (NGF) synthesis/secretion, was isolated.	Epinephrine	57-68	nerve growth factor	Rattus norvegicus	101-104
7532621-4	1994	Epinephrine induced NGF synthesis/secretion prominently in serum-free cultures of C6-10A cells and in cultures with a high cell density, but not in serum-containing cultures.	Epinephrine	0-11	nerve growth factor	Rattus norvegicus	20-23
7532621-6	1994	NGF secretion was induced by catecholaminergic compounds in the following order isoproterenol &gt; epinephrine = norepinephrine &gt;&gt; dopamine.	Epinephrine	99-110	nerve growth factor	Rattus norvegicus	0-3
7956410-0	1994	The effect of the total cumulative epinephrine dose administered during human CPR on hemodynamic, oxygen transport, and utilization variables in the postresuscitation period.	Epinephrine	35-46	cytochrome p450 oxidoreductase	Homo sapiens	78-81
7956410-1	1994	BACKGROUND: Studies evaluating the dose of epinephrine required to optimize return of spontaneous circulation and survival after CPR have shown that doses greater than recommended by advanced cardiac life support (ACLS) improve coronary perfusion pressure and short-term resuscitation rates.	Epinephrine	43-54	cytochrome p450 oxidoreductase	Homo sapiens	129-132
7962332-8	1994	These data suggest that 1) the reduced epinephrine responses in well controlled IDDM may not be specific for the hypoglycemic stimulus alone, but may also occur in response to other nonhypoglycemic stimuli; 2) cortisol responses to hypoglycemia are reduced in well controlled IDDM, whereas the ACTH response to a non-hypoglycemic stimulus remains intact; and 3) GH responses to both hypoglycemic and nonhypoglycemic stimuli are preserved in well controlled IDDM.	Epinephrine	39-50	proopiomelanocortin	Homo sapiens	294-298
8000434-1	1994	We cloned and sequenced the mouse phenylethanolamine N-methyltransferase (PNMT) gene which encodes the enzyme that catalyses the conversion of norepinephrine to epinephrine.	Epinephrine	146-157	phenylethanolamine-N-methyltransferase	Mus musculus	34-72
8000434-1	1994	We cloned and sequenced the mouse phenylethanolamine N-methyltransferase (PNMT) gene which encodes the enzyme that catalyses the conversion of norepinephrine to epinephrine.	Epinephrine	146-157	phenylethanolamine-N-methyltransferase	Mus musculus	74-78
7826555-0	1994	Dissociation of renin and aldosterone during low-dose epinephrine infusion.	Epinephrine	54-65	renin	Homo sapiens	16-21
7826555-1	1994	Besides its dose-dependent alpha- and beta-adrenoceptor-mediated vascular action, hormonal effects of epinephrine also involve the activation of renin secretion by direct stimulation of renal beta 1-adrenoceptors.	Epinephrine	102-113	renin	Homo sapiens	145-150
7826555-2	1994	To determine the interrelation between increased plasma renin activity in response to epinephrine and plasma aldosterone concentration and renal excretion of potassium and sodium, 26 normal subjects were subjected to 4 h of an intravenous infusion of low-dose epinephrine (12 ng/kg/min).	Epinephrine	86-97	renin	Homo sapiens	56-61
7826555-2	1994	To determine the interrelation between increased plasma renin activity in response to epinephrine and plasma aldosterone concentration and renal excretion of potassium and sodium, 26 normal subjects were subjected to 4 h of an intravenous infusion of low-dose epinephrine (12 ng/kg/min).	Epinephrine	260-271	renin	Homo sapiens	56-61
7826555-4	1994	Plasma renin activity (PRA) increased by 56% (P &lt; .01) during epinephrine infusion, whereas plasma aldosterone concentration remained constant.	Epinephrine	65-76	renin	Homo sapiens	7-12
8076685-1	1994	The addition of corticotropin-releasing factor (CRF) to molluscan hemocytes induces the release of biogenic amines (norepinephrine, epinephrine, dopamine), a phenomenon we have considered as an ancestral type of stress response [(1992) Gen. Comp.	Epinephrine	119-130	corticotropin releasing hormone	Homo sapiens	16-46
8077240-2	1994	The wild type alpha 1BAR was rapidly phosphorylated upon exposure to the agonist epinephrine as well as to phorbol ester as assessed by immunoprecipitation of the receptor with antiserum raised against its amino-terminal portion.	Epinephrine	81-92	adrenoceptor alpha 1B	Homo sapiens	14-24
8077240-3	1994	Exposure of cells expressing the wild type alpha 1BAR to epinephrine resulted also in rapid homologous desensitization of receptor-mediated response on polyphosphoinositide hydrolysis.	Epinephrine	57-68	adrenoceptor alpha 1B	Homo sapiens	43-53
7916536-10	1994	In addition, chloroethylclonidine, an irreversible inhibitor of the alpha 1B-adrenoceptor, inhibited the epinephrine stimulation of PI hydrolysis by 35%.	Epinephrine	105-116	adrenoceptor alpha 1B	Rattus norvegicus	68-89
8051564-1	1994	The effects of a single and of repeated immobilization stress on the expression of the final enzyme involved in epinephrine biosynthesis, phenylethanolamine N-methyltransferase (PNMT), are described.	Epinephrine	112-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	138-176
8051564-1	1994	The effects of a single and of repeated immobilization stress on the expression of the final enzyme involved in epinephrine biosynthesis, phenylethanolamine N-methyltransferase (PNMT), are described.	Epinephrine	112-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	178-182
7835624-13	1994	These COMT inhibitors also decrease the amount of COMT dependent metabolites of adrenaline and noradrenaline in plasma.	Epinephrine	80-90	catechol-O-methyltransferase	Homo sapiens	6-10
7835624-13	1994	These COMT inhibitors also decrease the amount of COMT dependent metabolites of adrenaline and noradrenaline in plasma.	Epinephrine	80-90	catechol-O-methyltransferase	Homo sapiens	50-54
7520441-7	1994	We demonstrate that the secondary wave of platelet aggregation and serotonin secretion induced by epinephrine and ADP, but not by the thromboxane analog U46619, was augmented by KL/SCF.	Epinephrine	98-109	KIT ligand	Homo sapiens	178-180
7520441-7	1994	We demonstrate that the secondary wave of platelet aggregation and serotonin secretion induced by epinephrine and ADP, but not by the thromboxane analog U46619, was augmented by KL/SCF.	Epinephrine	98-109	KIT ligand	Homo sapiens	181-184
7520441-8	1994	The effect of KL/SCF on epinephrine/ADP-induced platelet activation appeared to be mediated in part through the thromboxane pathway.	Epinephrine	24-35	KIT ligand	Homo sapiens	14-20
8062509-13	1994	Fibrinogen binding in response to "weak" agonist stimulation, by low concentrations of ADP or, in a subgroup by adrenaline, was in fact lower in the normal pregnant women than in the non-pregnant women.	Epinephrine	112-122	fibrinogen beta chain	Homo sapiens	0-10
7987375-7	1994	Three possible mechanisms are suggested to account for the rise in plasma glucose in the hepatic vein after injection of BMI: 1) that epinephrine is secreted by the adrenal medulla, 2) that epinephrine secretion stimulates glucagon secretion or 3) that there may be some direct innervation of the liver in rats.	Epinephrine	134-145	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	121-127
7987375-7	1994	Three possible mechanisms are suggested to account for the rise in plasma glucose in the hepatic vein after injection of BMI: 1) that epinephrine is secreted by the adrenal medulla, 2) that epinephrine secretion stimulates glucagon secretion or 3) that there may be some direct innervation of the liver in rats.	Epinephrine	190-201	BMI1 proto-oncogene, polycomb ring finger	Rattus norvegicus	121-127
7990274-4	1994	These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.	Epinephrine	145-156	tyrosine hydroxylase	Rattus norvegicus	92-94
7990274-4	1994	These results suggested that the hypertension of SHR may be related to the high activity of TH due to the high level of TH mRNA, which increases epinephrine and norepinephrine levels in the adrenal medulla.	Epinephrine	145-156	tyrosine hydroxylase	Rattus norvegicus	120-122
8013385-9	1994	IL-1 alpha significantly increased (P &lt; 0.05) epinephrine, PGE2, and corticosterone levels above those in medium-treated controls from primary adrenal cells.	Epinephrine	49-60	interleukin 1 alpha	Rattus norvegicus	0-10
16414754-4	1994	The nor adrenaline content of corpus cavernosum from insulin dependent (IDDM) and non insulin dependent (NIDDM) diabetic neuropathic patients was also found to be significantly lower (P &lt;0.02) than that of non diabetic non neuropathic patients.	Epinephrine	8-18	insulin	Homo sapiens	53-60
8088361-1	1994	Insulin-induced hypoglycaemia is a well-known stimulating factor for the release of adrenaline from adrenal medulla.	Epinephrine	84-94	insulin	Canis lupus familiaris	0-7
7935851-1	1994	The present study was undertaken to analyse the relationship between postnatal development of vascular beta 2-adrenoceptor-mediated responses and the content of adrenaline in the adrenal gland and its concentration in plasma.	Epinephrine	161-171	beta-2 adrenergic receptor	Canis lupus familiaris	103-122
8075868-7	1994	Cross-desensitization experiments with neuropeptide Y, adrenaline and moxonidine demonstrated the presence of homologous (both receptors) and heterologous desensitization (neuropeptide Y receptors only), and that the alpha 2A-adrenoceptor desensitization was not specific for phenylethylamine (adrenaline) or imidazoline agonists (moxonidine).	Epinephrine	294-304	adrenoceptor alpha 2A	Homo sapiens	217-238
7936115-11	1994	pretreatment with the vasopressin antagonist, phentolamine and propranolol and hence was possibly due to circulating adrenaline acting on vasodilator beta 2-adrenoceptors.	Epinephrine	117-127	arginine vasopressin	Rattus norvegicus	22-33
7514181-6	1994	Indeed, when epinephrine was added with fibrinogen and anti-LIBS6, large platelet aggregates formed and FAK phosphorylation occurred.	Epinephrine	13-24	fibrinogen beta chain	Homo sapiens	40-50
7514181-6	1994	Indeed, when epinephrine was added with fibrinogen and anti-LIBS6, large platelet aggregates formed and FAK phosphorylation occurred.	Epinephrine	13-24	protein tyrosine kinase 2	Homo sapiens	104-107
7514181-9	1994	Epinephrine costimulation of FAK phosphorylation was also prevented by chelation of intracellular Ca2+ with BAPTA or selective inhibition of protein kinase C (PKC) with bisindolylmaleimide, indicating that Ca2+ and PKC are necessary for FAK phosphorylation under these conditions.	Epinephrine	0-11	protein tyrosine kinase 2	Homo sapiens	29-32
7514181-9	1994	Epinephrine costimulation of FAK phosphorylation was also prevented by chelation of intracellular Ca2+ with BAPTA or selective inhibition of protein kinase C (PKC) with bisindolylmaleimide, indicating that Ca2+ and PKC are necessary for FAK phosphorylation under these conditions.	Epinephrine	0-11	protein tyrosine kinase 2	Homo sapiens	237-240
7514181-10	1994	Epinephrine also promoted FAK phosphorylation and adhesive spreading of apyrase-treated platelets on a fibrinogen matrix.	Epinephrine	0-11	protein tyrosine kinase 2	Homo sapiens	26-29
7514181-10	1994	Epinephrine also promoted FAK phosphorylation and adhesive spreading of apyrase-treated platelets on a fibrinogen matrix.	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	103-113
7915418-1	1994	Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected.	Epinephrine	0-10	gamma-glutamyltransferase 1	Rattus norvegicus	138-164
8084492-0	1994	Coinjections of NPY(1-36) or [Leu31,Pro34]NPY with adrenaline in the nucleus tractus solitarius of the rat counteract the vasodepressor responses to adrenaline.	Epinephrine	51-61	neuropeptide Y	Rattus norvegicus	42-45
8084492-0	1994	Coinjections of NPY(1-36) or [Leu31,Pro34]NPY with adrenaline in the nucleus tractus solitarius of the rat counteract the vasodepressor responses to adrenaline.	Epinephrine	149-159	neuropeptide Y	Rattus norvegicus	16-19
8084492-0	1994	Coinjections of NPY(1-36) or [Leu31,Pro34]NPY with adrenaline in the nucleus tractus solitarius of the rat counteract the vasodepressor responses to adrenaline.	Epinephrine	149-159	neuropeptide Y	Rattus norvegicus	42-45
8084492-3	1994	The vasodepressor action of a close to ED50 dose of adrenaline (0.5 nmol) was significantly counteracted by a threshold dose of NPY (1-36) (1 pmol) and of the NPY Y1 receptor agonist [Leu31,Pro34]NPY (2.5 pmol) microinjected into the Sol, but not by a threshold dose of NPY(13-36)(50 fmol), a selective Y2 receptor agonist.	Epinephrine	52-62	neuropeptide Y	Rattus norvegicus	128-131
8084492-3	1994	The vasodepressor action of a close to ED50 dose of adrenaline (0.5 nmol) was significantly counteracted by a threshold dose of NPY (1-36) (1 pmol) and of the NPY Y1 receptor agonist [Leu31,Pro34]NPY (2.5 pmol) microinjected into the Sol, but not by a threshold dose of NPY(13-36)(50 fmol), a selective Y2 receptor agonist.	Epinephrine	52-62	neuropeptide Y	Rattus norvegicus	159-162
8084492-3	1994	The vasodepressor action of a close to ED50 dose of adrenaline (0.5 nmol) was significantly counteracted by a threshold dose of NPY (1-36) (1 pmol) and of the NPY Y1 receptor agonist [Leu31,Pro34]NPY (2.5 pmol) microinjected into the Sol, but not by a threshold dose of NPY(13-36)(50 fmol), a selective Y2 receptor agonist.	Epinephrine	52-62	neuropeptide Y	Rattus norvegicus	159-162
8084492-3	1994	The vasodepressor action of a close to ED50 dose of adrenaline (0.5 nmol) was significantly counteracted by a threshold dose of NPY (1-36) (1 pmol) and of the NPY Y1 receptor agonist [Leu31,Pro34]NPY (2.5 pmol) microinjected into the Sol, but not by a threshold dose of NPY(13-36)(50 fmol), a selective Y2 receptor agonist.	Epinephrine	52-62	neuropeptide Y	Rattus norvegicus	159-162
7914350-7	1994	Dose-response curves with epinephrine from lean mice were best fit to a two-component model comprised of 23% high affinity (K(act) = 1.42 x 10(-7) M) and 77% low affinity (K(act) = 1.67 x 10(-5) M) components, corresponding to activation of beta 1AR and beta 2AR conjointly, and beta 3AR, respectively.	Epinephrine	26-37	adrenergic receptor, beta 1	Mus musculus	241-249
7907998-0	1994	Regulation of human insulin gene transcription by glucose, epinephrine, and somatostatin.	Epinephrine	59-70	insulin	Homo sapiens	20-27
7907998-4	1994	Epinephrine significantly inhibited insulin-CAT reporter gene expression (61 +/- 5% of control), an effect mediated specifically by the human insulin gene promoter/enhancer sequence.	Epinephrine	0-11	insulin	Homo sapiens	36-43
7907998-4	1994	Epinephrine significantly inhibited insulin-CAT reporter gene expression (61 +/- 5% of control), an effect mediated specifically by the human insulin gene promoter/enhancer sequence.	Epinephrine	0-11	insulin	Homo sapiens	142-149
7907998-7	1994	Both epinephrine and somatostatin inhibited expression of the human insulin-CAT reporter gene in a concentration-dependent manner that paralleled inhibition of insulin secretion.	Epinephrine	5-16	insulin	Homo sapiens	68-75
7907998-7	1994	Both epinephrine and somatostatin inhibited expression of the human insulin-CAT reporter gene in a concentration-dependent manner that paralleled inhibition of insulin secretion.	Epinephrine	5-16	insulin	Homo sapiens	160-167
7907998-8	1994	These studies indicate that epinephrine and somatostatin lower HIT cell insulin mRNA levels in part by inhibiting insulin gene transcription.	Epinephrine	28-39	insulin	Homo sapiens	72-79
7907998-8	1994	These studies indicate that epinephrine and somatostatin lower HIT cell insulin mRNA levels in part by inhibiting insulin gene transcription.	Epinephrine	28-39	insulin	Homo sapiens	114-121
7908287-4	1994	When Chinese hamster ovary cells stably expressing each of the three receptor genes were incubated with epinephrine for 20 min, a marked decrease in sensitivity to subsequent agonist-mediated inhibition of adenylyl cyclase was observed for the alpha 2-C10 and alpha 2-C2 receptors but not for the alpha 2-C4 receptors.	Epinephrine	104-115	adrenoceptor alpha 2A	Homo sapiens	244-255
7908287-4	1994	When Chinese hamster ovary cells stably expressing each of the three receptor genes were incubated with epinephrine for 20 min, a marked decrease in sensitivity to subsequent agonist-mediated inhibition of adenylyl cyclase was observed for the alpha 2-C10 and alpha 2-C2 receptors but not for the alpha 2-C4 receptors.	Epinephrine	104-115	adrenergic receptor, alpha 2b	Mus musculus	260-270
7908287-5	1994	When similar incubations were performed with 32Pi-labeled cells and the receptors were immunoprecipitated with specific antibodies, alpha 2-C10 and alpha 2-C2 receptors were found to undergo an approximately 3-fold increase in receptor phosphorylation after epinephrine exposure.	Epinephrine	258-269	adrenoceptor alpha 2A	Homo sapiens	132-143
7908287-5	1994	When similar incubations were performed with 32Pi-labeled cells and the receptors were immunoprecipitated with specific antibodies, alpha 2-C10 and alpha 2-C2 receptors were found to undergo an approximately 3-fold increase in receptor phosphorylation after epinephrine exposure.	Epinephrine	258-269	adrenergic receptor, alpha 2b	Mus musculus	148-158
7908287-6	1994	When transfected into COS cells epinephrine also stimulated phosphorylation of alpha 2-C10 and alpha 2-C2 receptors while having only a slight effect on alpha 2-C4 receptors.	Epinephrine	32-43	adrenergic receptor, alpha 2a	Mus musculus	79-90
7908287-6	1994	When transfected into COS cells epinephrine also stimulated phosphorylation of alpha 2-C10 and alpha 2-C2 receptors while having only a slight effect on alpha 2-C4 receptors.	Epinephrine	32-43	adrenergic receptor, alpha 2b	Mus musculus	95-105
8045100-5	1994	To further investigate the central adrenergic regulation of GH secretion 10 micrograms of noradrenaline or adrenaline was microinjected (1 microliter) directly into the preoptic area of the hypothalamus of ovariectomized ewes.	Epinephrine	93-103	somatotropin	Ovis aries	60-62
8045100-6	1994	When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained.	Epinephrine	70-80	somatotropin	Ovis aries	125-127
8045100-6	1994	When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained.	Epinephrine	70-80	somatotropin	Ovis aries	125-127
8045100-6	1994	When the time of injection coincided with a GH trough period, both noradrenaline and adrenaline caused an increase in plasma GH concentrations, whereas if the injection coincided with an endogenous pulse of GH no additional GH response was obtained.	Epinephrine	70-80	somatotropin	Ovis aries	125-127
7910371-10	1994	Overall, the rank order of efficacy of these agonists to elicit stimulation of adenylyl cyclase activity by alpha 2C10 was epinephrine = norepinephrine = UK-14304 &gt; BHT-933 &gt; BHT-920 &gt; oxymetazoline.	Epinephrine	123-134	adrenoceptor alpha 2A	Homo sapiens	108-118
7914350-7	1994	Dose-response curves with epinephrine from lean mice were best fit to a two-component model comprised of 23% high affinity (K(act) = 1.42 x 10(-7) M) and 77% low affinity (K(act) = 1.67 x 10(-5) M) components, corresponding to activation of beta 1AR and beta 2AR conjointly, and beta 3AR, respectively.	Epinephrine	26-37	adrenergic receptor, beta 2	Mus musculus	254-262
7914350-7	1994	Dose-response curves with epinephrine from lean mice were best fit to a two-component model comprised of 23% high affinity (K(act) = 1.42 x 10(-7) M) and 77% low affinity (K(act) = 1.67 x 10(-5) M) components, corresponding to activation of beta 1AR and beta 2AR conjointly, and beta 3AR, respectively.	Epinephrine	26-37	adrenergic receptor, beta 3	Mus musculus	279-287
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Epinephrine	74-84	catechol-O-methyltransferase	Homo sapiens	0-4
7509734-11	1994	After 24 h of either norepinephrine or epinephrine infusion, IGFBP-1 mRNA levels in the liver of fetuses were increased significantly (5- to 7-fold) compared to those of vehicle infused fetuses.	Epinephrine	24-35	insulin-like growth factor-binding protein 1	Ovis aries	61-68
7911719-10	1994	Schild analysis of inhibition experiments with the alpha 1A-adrenoceptor-selective antagonists, 5-methyl-urapidil and (+/-)-tamsulosin, demonstrated that adrenaline causes its inotropic effects mainly via the alpha 1B-adrenoceptor subtype.	Epinephrine	154-164	adrenoceptor alpha 1A	Rattus norvegicus	51-72
7911719-10	1994	Schild analysis of inhibition experiments with the alpha 1A-adrenoceptor-selective antagonists, 5-methyl-urapidil and (+/-)-tamsulosin, demonstrated that adrenaline causes its inotropic effects mainly via the alpha 1B-adrenoceptor subtype.	Epinephrine	154-164	adrenoceptor alpha 1B	Rattus norvegicus	209-230
8157368-7	1994	The changes in interleukin-2 (IL-2) effect on proliferation and cytotoxic activity (LAK cell activity) were more pronounced in exercise experiments than during epinephrine.	Epinephrine	160-171	interleukin 2	Homo sapiens	15-28
8157368-7	1994	The changes in interleukin-2 (IL-2) effect on proliferation and cytotoxic activity (LAK cell activity) were more pronounced in exercise experiments than during epinephrine.	Epinephrine	160-171	interleukin 2	Homo sapiens	30-34
8307150-5	1994	The order of affinity of the bovine VMAT2 transporter to substrates is: serotonin &gt; dopamine = norepinephrine &gt; epinephrine.	Epinephrine	101-112	solute carrier family 18 member A2	Rattus norvegicus	36-41
7842240-4	1994	It was found that women chronically exposed to CS2 showed significantly lower levels of dopamine and lower activities of DBH (p &lt; 0.001), significantly lower urinary excretion of adrenaline (p &lt; 0.001), but insignificantly lower excretion of noradrenaline and vanillylmandelic acid.	Epinephrine	182-192	chorionic somatomammotropin hormone 2	Homo sapiens	47-50
7509435-0	1994	Histamine H1 receptor activation mediates the preferential release of adrenaline in the rat adrenal gland.	Epinephrine	70-80	histamine receptor H 1	Rattus norvegicus	0-21
7997146-9	1994	The daily excretion of adrenaline and noradrenaline in urine and concentrations of dopamine in plasma of women chronically exposed to CS2 were lower (p &lt; 0.001), while the concentrations of serotonin and prolactin in plasma were higher (p &lt; 0.001).	Epinephrine	23-33	chorionic somatomammotropin hormone 2	Homo sapiens	134-137
7862266-3	1994	All TRH doses studied enhanced blood pressure and noradrenaline and adrenaline secretion.	Epinephrine	53-63	thyrotropin releasing hormone	Rattus norvegicus	4-7
8190835-0	1994	Induction of plasma interleukin-6 by circulating adrenaline in the rat.	Epinephrine	49-59	interleukin 6	Rattus norvegicus	20-33
8190835-3	1994	Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations.	Epinephrine	52-62	interleukin 6	Rattus norvegicus	107-111
8190835-3	1994	Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations.	Epinephrine	52-62	interleukin 6	Rattus norvegicus	356-360
8190835-3	1994	Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations.	Epinephrine	202-212	interleukin 6	Rattus norvegicus	107-111
8190835-3	1994	Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations.	Epinephrine	202-212	interleukin 6	Rattus norvegicus	356-360
8190835-3	1994	Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations.	Epinephrine	202-212	interleukin 6	Rattus norvegicus	107-111
8190835-3	1994	Here we describe that in rats, SC administration of adrenaline induces a dose-dependent increase in plasma IL-6 concentrations, reaching its maximum after 2 h. In addition, intravenous (IV) infusion of adrenaline in a dose resulting in circulating adrenaline concentrations similar to those observed during stress, enhanced heart rate and increased plasma IL-6 concentrations.	Epinephrine	202-212	interleukin 6	Rattus norvegicus	356-360
8190835-4	1994	The increase in plasma IL-6 in response to adrenaline given by subcutaneous (SC) route and by IV infusion could be blocked by the beta-adrenergic receptor antagonist l-propranolol but not by d-propranolol.	Epinephrine	43-53	interleukin 6	Rattus norvegicus	23-27
8190835-5	1994	Based on these data we conclude that under physiological conditions circulating adrenaline may be involved in the control of IL-6 production, and thereby may modulate inflammatory responses.	Epinephrine	80-90	interleukin 6	Rattus norvegicus	125-129
7903535-10	1993	These results indicate that epinephrine stimulates high-affinity GTPase activity of G proteins (putatively Gi2), which are also coupled with thrombin receptors, in a Mg(2+)-dependent and stereospecific manner, via alpha 2A-adrenergic receptor activation in human platelet membrane preparations.	Epinephrine	28-39	coagulation factor II, thrombin	Homo sapiens	141-149
7903535-10	1993	These results indicate that epinephrine stimulates high-affinity GTPase activity of G proteins (putatively Gi2), which are also coupled with thrombin receptors, in a Mg(2+)-dependent and stereospecific manner, via alpha 2A-adrenergic receptor activation in human platelet membrane preparations.	Epinephrine	28-39	adrenoceptor alpha 2A	Homo sapiens	214-242
8006835-4	1994	The purpose of this study is to determine if ACh and VIP cause differential secretion of adrenaline and noradrenaline and whether the differential secretion also occurs when splanchnic nerves are stimulated at different frequencies.	Epinephrine	89-99	vasoactive intestinal peptide	Rattus norvegicus	53-56
8006835-11	1994	Perfusion with VIP (10 microM for 4 min) resulted in the secretion of 27 ng of catecholamines and the ratio of adrenaline to noradrenaline was 9.7.	Epinephrine	111-121	vasoactive intestinal peptide	Rattus norvegicus	15-18
8006835-12	1994	A higher concentration of VIP (20 microM for 4 min) resulted in the secretion of greater amounts of catecholamines (102 ng) without significantly altering the ratio of adrenaline to noradrenaline (10.9).	Epinephrine	168-178	vasoactive intestinal peptide	Rattus norvegicus	26-29
7912402-4	1994	COS cell hSVMT expression yielded nanomolar affinities for tetrabenazine and reserpine, micromolar affinities for haloperidol, GBR12909, serotonin, mazindol, nomifensin and d-amphetamine, while dopamine, epinephrine, norepinephrine and histamine each displayed millimolar affinities.	Epinephrine	204-215	solute carrier family 18 member A2	Homo sapiens	9-14
8174837-4	1994	Insulin sensitivity was estimated by an insulin (0.4 mU.kg-1 x min-1)-glucose (4.5 mg.kg-1 x min-1)-infusion test (IGIT) for 6.5 h. Mental stress evoked significant responses for adrenaline, cortisol and GH, their respective peak values being 0.27 +/- 0.05 nmol/l, 426 +/- 27 nmol/l and 7.6 +/- 1.8 micrograms/l, as well as increases in systolic and diastolic blood pressure and pulse rate The steady-state blood glucose levels, i.e. the mean blood glucose levels 3-6.5 h after the start of the IGIT, were significantly higher after stress, compared with those on the control day, 10.6 +/- 1.5 vs 8.7 +/- 1.4 mmol/l, p = 0.01, demonstrating impairment of the insulin sensitivity by mental stress.	Epinephrine	179-189	insulin	Homo sapiens	0-7
8138937-0	1994	Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats.	Epinephrine	27-38	catechol-O-methyltransferase	Rattus norvegicus	58-86
8138937-0	1994	Different metabolism of norepinephrine and epinephrine by catechol-O-methyltransferase and monoamine oxidase in rats.	Epinephrine	27-38	monoamine oxidase A	Rattus norvegicus	91-108
8107194-3	1994	In agreement with earlier studies using a more extensive LAT- deletion mutant, the 17 delta Pst(LAT-) virus reactivated with extremely low frequency upon epinephrine induction.	Epinephrine	154-165	linker for activation of T-cells family member 1	Oryctolagus cuniculus	96-99
8141272-6	1994	Plasma insulin concentration increased after repeated epinephrine treatment in both obese (14.3 +/- 0.6 to 18.2 +/- 1.6 microU/ml; P &lt; 0.05) and lean (8.4 +/- 1.3 to 11.1 +/- 1.5 microU/ml; P &lt; 0.01) subjects.	Epinephrine	54-65	insulin	Homo sapiens	7-14
8190350-5	1994	Present data support the hypothesis that adrenaline and/or noradrenaline could mediate the effects of both NPY and VIP on aldosterone secretion via beta 1 adrenergic receptors; alternatively, the steroidogenic effect of NPY or VIP could be related to direct interaction between NPY- or VIP-specific binding sites, present on the capsule/glomerular zone of the rat adrenal cortex, and beta 1 adrenergic receptors.	Epinephrine	41-51	neuropeptide Y	Rattus norvegicus	107-110
8190350-5	1994	Present data support the hypothesis that adrenaline and/or noradrenaline could mediate the effects of both NPY and VIP on aldosterone secretion via beta 1 adrenergic receptors; alternatively, the steroidogenic effect of NPY or VIP could be related to direct interaction between NPY- or VIP-specific binding sites, present on the capsule/glomerular zone of the rat adrenal cortex, and beta 1 adrenergic receptors.	Epinephrine	41-51	vasoactive intestinal peptide	Rattus norvegicus	115-118
8190350-5	1994	Present data support the hypothesis that adrenaline and/or noradrenaline could mediate the effects of both NPY and VIP on aldosterone secretion via beta 1 adrenergic receptors; alternatively, the steroidogenic effect of NPY or VIP could be related to direct interaction between NPY- or VIP-specific binding sites, present on the capsule/glomerular zone of the rat adrenal cortex, and beta 1 adrenergic receptors.	Epinephrine	41-51	vasoactive intestinal peptide	Rattus norvegicus	227-230
8190350-5	1994	Present data support the hypothesis that adrenaline and/or noradrenaline could mediate the effects of both NPY and VIP on aldosterone secretion via beta 1 adrenergic receptors; alternatively, the steroidogenic effect of NPY or VIP could be related to direct interaction between NPY- or VIP-specific binding sites, present on the capsule/glomerular zone of the rat adrenal cortex, and beta 1 adrenergic receptors.	Epinephrine	41-51	vasoactive intestinal peptide	Rattus norvegicus	227-230
8154929-1	1994	Catechol-O-methyltransferase (COMT) is involved in the metabolism of neurotransmitters such as epinephrine, norepinephrine and dopamine.	Epinephrine	95-106	catechol-O-methyltransferase	Homo sapiens	0-28
8154929-1	1994	Catechol-O-methyltransferase (COMT) is involved in the metabolism of neurotransmitters such as epinephrine, norepinephrine and dopamine.	Epinephrine	95-106	catechol-O-methyltransferase	Homo sapiens	30-34
7506054-0	1994	Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression.	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	74-84
7506054-0	1994	Epinephrine sensitizes human platelets in vivo and in vitro as studied by fibrinogen binding and P-selectin expression.	Epinephrine	0-11	selectin P	Homo sapiens	97-107
8200295-4	1994	Steady state epinephrine levels during a low-dose insulin (9 pM/kg/min) hypoglycemic clamp (2.9 +/- 0.1 mM) were approximately 2-fold higher compared with normal controls (10.6 vs. 5.5 +/- 0.7 nM).	Epinephrine	13-24	insulin	Homo sapiens	50-57
8200295-5	1994	Epinephrine levels during a high-dose insulin (30 pM/kg/min) hypoglycemic clamp (2.8 +/- 0.1 mM) were also increased compared with normal controls (13.1 vs. 8.8 +/- 0.6 nM).	Epinephrine	0-11	insulin	Homo sapiens	38-45
8275961-6	1994	This in vivo expression of proenkephalin was enhanced by adrenaline.	Epinephrine	57-67	proenkephalin	Rattus norvegicus	27-40
7584061-3	1994	Controlled treatment with epinephrine or forskolin allows for selectively killing CFTR- cells.	Epinephrine	26-37	CF transmembrane conductance regulator	Homo sapiens	82-86
8295490-8	1994	Then PAF in the final sample was determined by sensitive bioassay using rabbit platelets containing fibrinogen and epinephrine.	Epinephrine	115-126	PCNA clamp associated factor	Homo sapiens	5-8
8159777-4	1994	We have used a novel cDNA expression cloning strategy to isolate cDNAs for the antidepressant-sensitive serotonin transporter and for a reserpine-sensitive vesicular monoamine transporter which is critical for packaging serotonin, dopamine, norepinephrine, epinephrine and histamine into synaptic vesicles and secretory granules.	Epinephrine	244-255	solute carrier family 6 member 4	Homo sapiens	104-125
7938756-1	1994	The effect of preincubation of heparinized whole blood with endothelin-1 (ET-1) on the ADP (adenosine diphosphate) and epinephrine-induced platelet aggregation was examined in 20 healthy donors compared with 20 patients with chronic renal failure (CRF).	Epinephrine	119-130	endothelin 1	Homo sapiens	60-72
7938756-1	1994	The effect of preincubation of heparinized whole blood with endothelin-1 (ET-1) on the ADP (adenosine diphosphate) and epinephrine-induced platelet aggregation was examined in 20 healthy donors compared with 20 patients with chronic renal failure (CRF).	Epinephrine	119-130	endothelin 1	Homo sapiens	74-78
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Epinephrine	74-84	catechol-O-methyltransferase	Homo sapiens	44-48
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Epinephrine	86-97	catechol-O-methyltransferase	Homo sapiens	0-4
27520516-6	1994	COMT inhibitors also decrease the levels of COMT-dependent metabolites of adrenaline (epinephrine) and noradrenaline (norepinephrine) in plasma.Entacapone, to1capone and CGP 28014 improve the bioavailability of levodopa and inhibit the formation of 3-0-methyldopa in human volunteers.	Epinephrine	86-97	catechol-O-methyltransferase	Homo sapiens	44-48
7509734-10	1994	Norepinephrine and epinephrine infusions increased IGFBP-1 levels significantly (2- to 5-fold) in fetal plasma within 8-12 h, and the time course pattern of elevation of plasma IGFBP-1 levels was similar to that observed in prolonged hypoxia.	Epinephrine	3-14	insulin-like growth factor-binding protein 1	Ovis aries	51-58
7903385-8	1993	KB values for antagonist inhibition of epinephrine-induced, endothelium-dependent vascular relaxation correlated best with Kl values for antagonist binding at the alpha-2A adrenergic receptor subtype.	Epinephrine	39-50	adrenoceptor alpha 2A	Sus scrofa	163-191
8123296-9	1993	We conclude that the formation of inositol phosphates, increases in cytosolic Ca2+, and phosphorylation of MLC affected by Quin-2 are not coupled to the mechanisms by which platelets develop stickiness, undergo shape change, spreading, and aggregation in response to epinephrine and AA.	Epinephrine	267-278	modulator of VRAC current 1	Homo sapiens	107-110
8245983-5	1993	The rank order for substrate inhibition of [3H]5-HT uptake for both the previously reported rat vMAT1 and the human transporter clone followed the order 5-HT &gt; dopamine &gt; epinephrine &gt; norepinephrine &gt; 1-methyl-4-phenylpyridinium &gt; 2-phenylethylamine &gt; histamine.	Epinephrine	177-188	solute carrier family 18 member A1	Rattus norvegicus	96-101
8267422-5	1993	Epinephrine (mean dose, 0.07 +/- 0.02 micrograms.kg-1.min-1) was administered via the central venous route, then via the left atrium, then via the central venous route again.	Epinephrine	0-11	CD59 molecule (CD59 blood group)	Homo sapiens	54-59
8124409-1	1993	We previously showed that intravenous insulin increased plasma noradrenaline during euglycemia and without concomitant changes in plasma adrenaline.	Epinephrine	66-76	insulin	Homo sapiens	38-45
8305658-6	1993	With LA administration of epinephrine, systemic arterial pressure (systolic arterial pressure and diastolic arterial pressure) (SAP, DAP) were also elevated to a greater extent than by CV administration.	Epinephrine	26-37	SH2 domain containing 1A	Homo sapiens	128-131
8305658-6	1993	With LA administration of epinephrine, systemic arterial pressure (systolic arterial pressure and diastolic arterial pressure) (SAP, DAP) were also elevated to a greater extent than by CV administration.	Epinephrine	26-37	death associated protein	Homo sapiens	133-136
8134705-13	1993	There was a moderate positive correlation between aortic pressure and circulating AVP levels after the first dose of epinephrine (R = 0.5).	Epinephrine	117-128	arginine vasopressin	Canis lupus familiaris	82-85
7901205-5	1993	In the presence of guanine nucleotide, Ile164 displayed a lower binding affinity for epinephrine as compared with the wild-type beta 2AR (Ki = 1450 +/- 79 versus 368 +/- 39 nM; p &lt; 0.001).	Epinephrine	85-96	adrenoceptor beta 2	Homo sapiens	128-136
8287640-9	1993	In the second hour, adrenaline rose significantly (P &lt; 0.05, analysis of variance) with a blood glucose of 3.3 and 3.7 mmol/l, as did cortisol and heart rate at 3.3 mmol/l, but glucagon, prolactin, sweating rate, symptom score and blood pressure were the same during the second hour on all three visits.	Epinephrine	20-30	prolactin	Homo sapiens	190-199
8238012-5	1993	Activation-dependent receptor function of the GP IIb-IIIa complex was studied with 125I-fibrinogen and 125I-vWF binding to washed platelets stimulated with adenosine diphosphate plus epinephrine (10 mumol/L each).	Epinephrine	183-194	integrin subunit alpha 2b	Homo sapiens	46-52
8282042-9	1993	Immunostaining with the use of antibodies to vimentin and actin revealed disorganization and condensation of cytoskeletal fibers in trabecular meshwork cells after treatment with epinephrine and dipivefrin.	Epinephrine	179-190	vimentin	Bos taurus	45-53
8282042-9	1993	Immunostaining with the use of antibodies to vimentin and actin revealed disorganization and condensation of cytoskeletal fibers in trabecular meshwork cells after treatment with epinephrine and dipivefrin.	Epinephrine	179-190	actin epsilon 1	Bos taurus	58-63
8293770-2	1993	Since all three peptides are able to modulate catecholamine release, a change in noradrenaline and adrenaline release should be expected when angiotensin I converting enzyme (kininase II) is inhibited.	Epinephrine	84-94	angiotensinogen	Homo sapiens	142-155
8114953-4	1993	beta 2-adrenoceptors were activated by (-)-adrenaline during beta 1-adrenoceptor blockade with 300 nmol/l CGP 20712A.	Epinephrine	39-53	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
8293770-2	1993	Since all three peptides are able to modulate catecholamine release, a change in noradrenaline and adrenaline release should be expected when angiotensin I converting enzyme (kininase II) is inhibited.	Epinephrine	84-94	angiotensin I converting enzyme	Homo sapiens	175-186
8114953-4	1993	beta 2-adrenoceptors were activated by (-)-adrenaline during beta 1-adrenoceptor blockade with 300 nmol/l CGP 20712A.	Epinephrine	39-53	adrenoceptor beta 1	Homo sapiens	61-80
8276080-7	1993	The facilitation of the evoked overflow of both noradrenaline and adrenaline was blocked by the selective beta 2-adrenoceptor antagonist, ICI 118,551 (0.3 mg/kg).	Epinephrine	51-61	adrenoceptor beta 2	Rattus norvegicus	106-125
8216383-3	1993	The procedure is suitable for use with a wide range of MAO substrates, although 5-hydroxytryptamine, adrenaline and noradrenaline are too readily oxidized by hydrogen peroxide to be used.	Epinephrine	101-111	monoamine oxidase A	Rattus norvegicus	55-58
8215639-1	1993	OBJECTIVE: The authors sought to determine how temporary insulin suppression might alter the catabolic effects of cortisol, glucagon, and epinephrine.	Epinephrine	138-149	insulin	Homo sapiens	57-64
7902002-5	1993	Insulin infusion resulted in hyperinsulinemic-hypoglycemia, a surge in epinephrine and norepinephrine concentration, and increases in the combined ventricular output and regional blood flow to the heart, adrenal glands, kidney, gastrointestinal tract, liver, fat, muscle, carcass, and placenta.	Epinephrine	71-82	LOC105613195	Ovis aries	0-7
8215639-5	1993	An infusion of hydrocortisone, glucagon, and epinephrine increases both stress hormone concentrations and insulin levels.	Epinephrine	45-56	insulin	Homo sapiens	106-113
8259557-6	1993	(3) The response of CP/CPK-treated thrombin- or platelet-activating factor (PAF)-stimulated platelets was markedly increased by a subsequent addition of adrenaline.	Epinephrine	153-163	coagulation factor II, thrombin	Homo sapiens	35-43
8102599-5	1993	Responses to (-)-epinephrine were antagonized to a variable degree by the blockers, suggesting heterogeneous contribution of beta 1AR and beta 2AR among cells.	Epinephrine	13-28	adrenoceptor beta 1	Homo sapiens	125-133
8102599-5	1993	Responses to (-)-epinephrine were antagonized to a variable degree by the blockers, suggesting heterogeneous contribution of beta 1AR and beta 2AR among cells.	Epinephrine	13-28	adrenoceptor beta 2	Homo sapiens	138-146
8102599-8	1993	These observations suggest that both beta 1AR and beta 2AR contribute to the increase in contraction amplitude with (-)-epinephrine in this group of myocytes.	Epinephrine	116-131	adrenoceptor beta 1	Homo sapiens	37-45
8102599-8	1993	These observations suggest that both beta 1AR and beta 2AR contribute to the increase in contraction amplitude with (-)-epinephrine in this group of myocytes.	Epinephrine	116-131	adrenoceptor beta 2	Homo sapiens	50-58
8102599-12	1993	At low (-)-epinephrine concentrations, contractile responses are predominantly mediated by beta 2AR rather than beta 1AR in myocytes from failing hearts.	Epinephrine	7-22	adrenoceptor beta 2	Homo sapiens	91-99
8277227-0	1993	Concentration-dependent effects of adrenaline on the profile of insulin secretion from isolated human islets of Langerhans.	Epinephrine	35-45	insulin	Homo sapiens	64-71
8277227-1	1993	The effects of the mixed alpha/beta-agonist adrenaline on insulin secretion from isolated human islets of Langerhans were studied.	Epinephrine	44-54	insulin	Homo sapiens	58-65
8277227-2	1993	In static incubation experiments, adrenaline (0.1 nmol/l to 10 mumol/l) caused a concentration-dependent inhibition of glucose-induced insulin secretion from isolated human islets.	Epinephrine	34-44	insulin	Homo sapiens	135-142
8277227-4	1993	When employed at a high concentration (1 mumol/l), adrenaline caused a sustained inhibition of glucose-induced insulin secretion, which could be relieved by the addition of the alpha 2-antagonist yohimbine (10 mumol/l).	Epinephrine	51-61	insulin	Homo sapiens	111-118
8277227-11	1993	Adrenaline interacts with both of these but the alpha 2-response is predominant and can overcome the tendency of beta 2-adrenoceptors to potentiate insulin release.	Epinephrine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	113-119
8277227-11	1993	Adrenaline interacts with both of these but the alpha 2-response is predominant and can overcome the tendency of beta 2-adrenoceptors to potentiate insulin release.	Epinephrine	0-10	insulin	Homo sapiens	148-155
7904912-0	1993	Epinephrine effects on gastrin and gastric secretions in normal and stress-susceptible pigs and in dogs.	Epinephrine	0-11	gastrin	Sus scrofa	23-30
7904912-2	1993	Epinephrine induced plasma gastrin concentration increased linearly in dogs, and significantly in pigs.	Epinephrine	0-11	gastrin	Canis lupus familiaris	27-34
8294140-0	1993	Beta-adrenergic receptors mediate in vivo the adrenaline inhibition of lipopolysaccharide-induced tumor necrosis factor release.	Epinephrine	46-56	tumor necrosis factor	Homo sapiens	98-119
8294140-1	1993	Adrenaline has been shown to inhibit the release of tumor necrosis factor (TNF) elicited by lipopolysaccharide (LPS) when tested in vitro on cultured human blood cells and rat macrophages.	Epinephrine	0-10	tumor necrosis factor	Homo sapiens	52-73
8294140-1	1993	Adrenaline has been shown to inhibit the release of tumor necrosis factor (TNF) elicited by lipopolysaccharide (LPS) when tested in vitro on cultured human blood cells and rat macrophages.	Epinephrine	0-10	tumor necrosis factor	Homo sapiens	75-78
8294140-2	1993	In this report we have examined the effect of the in vivo administration of adrenaline on TNF serum levels induced by LPS.	Epinephrine	76-86	tumor necrosis factor	Homo sapiens	90-93
8294140-3	1993	In agreement with in vitro data, adrenaline (0.1 mg/kg, s.c.) was found to inhibit in the mouse the LPS-induced TNF release.	Epinephrine	33-43	tumor necrosis factor	Homo sapiens	112-115
8294140-5	1993	These data demonstrate that: (i) adrenaline is an effective antagonist of LPS-induced TNF release in vivo, and (ii) its effect is mediated by beta-adrenergic receptors.	Epinephrine	33-43	tumor necrosis factor	Homo sapiens	86-89
7902547-0	1993	Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain.	Epinephrine	79-89	fibroblast growth factor 2	Rattus norvegicus	0-30
7902547-0	1993	Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain.	Epinephrine	79-89	fibroblast growth factor 2	Rattus norvegicus	32-36
7902547-0	1993	Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain.	Epinephrine	79-89	fibroblast growth factor 2	Rattus norvegicus	38-43
7902547-1	1993	By means of two colour immunofluorescence procedures it has been possible to demonstrate in the rat brain the coexistence of TH and bFGF immunoreactivities (IRs) in the perikarya of large numbers of noradrenaline (NA) nerve cells of the locus coeruleus and of the NA cell groups A1, A5 and A7 and in many perikarya of the adrenaline (A) cell groups C1, C2 and C3.	Epinephrine	202-212	fibroblast growth factor 2	Rattus norvegicus	132-136
8363112-12	1993	High-dose epinephrine administration repletes phosphocreatine during closed-chest CPR, thereby increasing myocardial energy stores.	Epinephrine	10-21	cytochrome p450 oxidoreductase	Sus scrofa	82-85
7689042-9	1993	P-selectin expression and fibrinogen binding were found after the addition of cocaine alone to blood taken from some but not all donors; however, platelet activation in response to submaximal concentrations of the agonists ADP or epinephrine was enhanced by a low concentration of cocaine added to blood from every donor.	Epinephrine	230-241	selectin P	Homo sapiens	0-10
8283972-5	1993	The epinephrine (10(-5) M) or phenylephrine (10(-4) M)-induced increase in (Ca(2+)-Mg2+)-ATPase activity was disappeared in the presence of regucalcin; in this case the effect of regucalcin was also weakened.	Epinephrine	4-15	regucalcin	Rattus norvegicus	179-189
8283972-5	1993	The epinephrine (10(-5) M) or phenylephrine (10(-4) M)-induced increase in (Ca(2+)-Mg2+)-ATPase activity was disappeared in the presence of regucalcin; in this case the effect of regucalcin was also weakened.	Epinephrine	4-15	regucalcin	Rattus norvegicus	140-150
8259557-6	1993	(3) The response of CP/CPK-treated thrombin- or platelet-activating factor (PAF)-stimulated platelets was markedly increased by a subsequent addition of adrenaline.	Epinephrine	153-163	PCNA clamp associated factor	Homo sapiens	48-74
8259557-6	1993	(3) The response of CP/CPK-treated thrombin- or platelet-activating factor (PAF)-stimulated platelets was markedly increased by a subsequent addition of adrenaline.	Epinephrine	153-163	PCNA clamp associated factor	Homo sapiens	76-79
8259557-7	1993	When hirudin or BN 50726 was added just prior to adrenaline to terminate the activation by thrombin or PAF, respectively, the stimulating effect of adrenaline was also abolished.	Epinephrine	148-158	coagulation factor II, thrombin	Homo sapiens	91-99
8259557-7	1993	When hirudin or BN 50726 was added just prior to adrenaline to terminate the activation by thrombin or PAF, respectively, the stimulating effect of adrenaline was also abolished.	Epinephrine	148-158	PCNA clamp associated factor	Homo sapiens	103-106
8259557-9	1993	When adrenaline was added instead of a second addition of PAF, the stimulating effect of adrenaline was gradually decreased and prevented in parallel with the homologous desensitization of PAF.	Epinephrine	5-15	PCNA clamp associated factor	Homo sapiens	189-192
8259557-9	1993	When adrenaline was added instead of a second addition of PAF, the stimulating effect of adrenaline was gradually decreased and prevented in parallel with the homologous desensitization of PAF.	Epinephrine	89-99	PCNA clamp associated factor	Homo sapiens	58-61
8507867-5	1993	The increase in t-PA secretion during exercise was directly proportional to the epinephrine concentration in blood with the same ratio of t-PA secretion to epinephrine as found during epinephrine infusion, suggesting that increased plasma epinephrine during exercise was the primary stimulus for t-PA secretion.	Epinephrine	156-167	chromosome 20 open reading frame 181	Homo sapiens	16-20
7691355-1	1993	Chromogranin A (CGA) is a member of a family of highly acidic proteins co-stored and co-secreted with adrenaline and noradrenaline in the adrenal medulla.	Epinephrine	102-112	chromogranin A	Bos taurus	0-14
8393293-6	1993	On isolated adipocytes, PYY (10(-7) M) inhibited lipolysis by 58 +/- 2% in femoral and 14 +/- 4% in pericolonic fat cells; epinephrine had the following similar response: 62 +/- 5 and 26 +/- 8%, respectively.	Epinephrine	123-134	peptide YY	Homo sapiens	24-27
8325998-1	1993	Rat skeletal muscle contains two enzymes which can make epinephrine: phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase.	Epinephrine	56-67	phenylethanolamine-N-methyltransferase	Rattus norvegicus	69-107
8325998-1	1993	Rat skeletal muscle contains two enzymes which can make epinephrine: phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase.	Epinephrine	56-67	phenylethanolamine-N-methyltransferase	Rattus norvegicus	109-113
8331563-1	1993	Normetanephrine (NMN) and metanephrine (MN) are produced by the actions of catechol-O-methyltransferase on norepinephrine (NE) and epinephrine (E).	Epinephrine	110-121	catechol-O-methyltransferase	Rattus norvegicus	75-103
8375774-0	1993	[Epinephrine in CPR--what is the optimal dose?	Epinephrine	1-12	cytochrome p450 oxidoreductase	Homo sapiens	16-19
8484505-9	1993	However, up to a dose of 30 micrograms/kg (A30), a dose-dependent decrease in the maximum percent changes of both epinephrine and norepinephrine occurred in response to INT.	Epinephrine	114-125	immunoglobulin kappa variable 1-17	Homo sapiens	43-46
8489206-0	1993	Loss of C1 and C3 epinephrine-synthesizing neurons in the medulla oblongata in Parkinson"s disease.	Epinephrine	18-29	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	8-17
8387773-8	1993	Studies on cultured anterior pituitary cells suggested that adrenaline and noradrenaline may influence the secretion of ACTH, prolactin and TSH directly at the level of the pituitary.	Epinephrine	60-70	proopiomelanocortin	Homo sapiens	120-124
8458643-1	1993	Several drugs that block epinephrine synthesis by inhibiting phenylethanolamine N-methyltransferase (PNMT) lower blood pressure in hypertensive rats.	Epinephrine	25-36	phenylethanolamine-N-methyltransferase	Rattus norvegicus	61-99
8458643-1	1993	Several drugs that block epinephrine synthesis by inhibiting phenylethanolamine N-methyltransferase (PNMT) lower blood pressure in hypertensive rats.	Epinephrine	25-36	phenylethanolamine-N-methyltransferase	Rattus norvegicus	101-105
8254520-4	1993	Infusions of VIP at a dose of 0.13 micrograms min-1 kg-1 caused a small, but significant increase in adrenaline and noradrenaline output which was, however, far below the level recorded previously in response to acetylcholine (0.7 micrograms min-1 kg-1).	Epinephrine	101-111	vasoactive intestinal peptide	Bos taurus	13-16
8224035-7	1993	Insulin-dependent diabetes mellitus (IDDM) patients must rely heavily on their ability to secrete epinephrine to overcome a defective glucagon response.	Epinephrine	98-109	insulin	Homo sapiens	0-7
8507867-0	1993	A kinetic model of the circulatory regulation of tissue plasminogen activator during exercise, epinephrine infusion, and endurance training.	Epinephrine	95-106	chromosome 20 open reading frame 181	Homo sapiens	49-77
8507867-2	1993	Infusion of epinephrine stimulated an increase in t-PA secretion that was proportional to the plasma epinephrine concentration.	Epinephrine	12-23	chromosome 20 open reading frame 181	Homo sapiens	50-54
8507867-2	1993	Infusion of epinephrine stimulated an increase in t-PA secretion that was proportional to the plasma epinephrine concentration.	Epinephrine	101-112	chromosome 20 open reading frame 181	Homo sapiens	50-54
8507867-3	1993	In addition, epinephrine infusion increased hepatic blood flow and t-PA clearance, thus slowing the increase of plasma t-PA levels.	Epinephrine	13-24	chromosome 20 open reading frame 181	Homo sapiens	67-71
8507867-3	1993	In addition, epinephrine infusion increased hepatic blood flow and t-PA clearance, thus slowing the increase of plasma t-PA levels.	Epinephrine	13-24	chromosome 20 open reading frame 181	Homo sapiens	119-123
8507867-5	1993	The increase in t-PA secretion during exercise was directly proportional to the epinephrine concentration in blood with the same ratio of t-PA secretion to epinephrine as found during epinephrine infusion, suggesting that increased plasma epinephrine during exercise was the primary stimulus for t-PA secretion.	Epinephrine	80-91	chromosome 20 open reading frame 181	Homo sapiens	16-20
8507867-5	1993	The increase in t-PA secretion during exercise was directly proportional to the epinephrine concentration in blood with the same ratio of t-PA secretion to epinephrine as found during epinephrine infusion, suggesting that increased plasma epinephrine during exercise was the primary stimulus for t-PA secretion.	Epinephrine	156-167	chromosome 20 open reading frame 181	Homo sapiens	16-20
8389195-1	1993	In the present study, we investigated whether stimulation of platelets by epinephrine affects the Na+/H+ exchanger, an antiport that regulates the cytosolic pH (pHi).	Epinephrine	74-85	glucose-6-phosphate isomerase	Homo sapiens	161-164
8329564-4	1993	The platelet electrophoretic mobility decreases from -2 (mu-cm)/(V-s) to -0.5 (mu-cm)/(V-s) when the platelet is activated with either 1 microM ADP, 10 microM epinephrine or 0.5 NIH U/ml alpha-thrombin.	Epinephrine	159-170	coagulation factor II, thrombin	Homo sapiens	193-201
7685382-8	1993	In addition, the adrenochrome reaction, which measures the oxidation of epinephrine to adrenochrome, was used to measure the increased oxygen radical-flux resulting from the metabolism of CyA, FK-506 and CCl4.	Epinephrine	72-83	C-C motif chemokine ligand 4	Rattus norvegicus	204-208
8335063-1	1993	Ketanserin, a 5HT2 receptor antagonist completely blocked the response of 5-HT plus epinephrine and this in the nanomolar concentration range in which the drug selectively antagonizes 5-HT2 receptor-mediated responses.	Epinephrine	84-95	5-hydroxytryptamine receptor 2A	Homo sapiens	14-27
8490165-3	1993	In this study, we show that platelets activated with either adenosine-5"-diphosphate or epinephrine induce IL-8 secretion by EC.	Epinephrine	88-99	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
8099794-4	1993	This has been attributed to the absence of the norepinephrine-methylating enzyme, phenylethanolamine-N-methyltransferase (PNMT), required for epinephrine synthesis.	Epinephrine	50-61	phenylethanolamine N-methyltransferase	Homo sapiens	82-120
8099794-4	1993	This has been attributed to the absence of the norepinephrine-methylating enzyme, phenylethanolamine-N-methyltransferase (PNMT), required for epinephrine synthesis.	Epinephrine	50-61	phenylethanolamine N-methyltransferase	Homo sapiens	122-126
8496333-2	1993	Plasma epinephrine levels were increased by 71% during the last 60 minutes of hypoglycemia in the high insulin study (840 +/- 180 vs 1440 +/- 310 pmol/L, respectively p = 0.006).	Epinephrine	7-18	insulin	Homo sapiens	103-110
8443867-1	1993	Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin.	Epinephrine	92-103	protein kinase C, epsilon	Rattus norvegicus	0-24
7951503-1	1993	Biochemical investigations have shown the presence of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine (NE) to epinephrine (E) in human pregnant tissues, e.g. myometrium and fetal membranes.	Epinephrine	130-141	phenylethanolamine N-methyltransferase	Homo sapiens	65-103
7951503-1	1993	Biochemical investigations have shown the presence of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts norepinephrine (NE) to epinephrine (E) in human pregnant tissues, e.g. myometrium and fetal membranes.	Epinephrine	130-141	phenylethanolamine N-methyltransferase	Homo sapiens	105-109
8473394-0	1993	Effects of different plasma glucose concentrations on lipolytic and ketogenic responsiveness to epinephrine in type I (insulin-dependent) diabetic subjects.	Epinephrine	96-107	insulin	Homo sapiens	119-126
8507867-5	1993	The increase in t-PA secretion during exercise was directly proportional to the epinephrine concentration in blood with the same ratio of t-PA secretion to epinephrine as found during epinephrine infusion, suggesting that increased plasma epinephrine during exercise was the primary stimulus for t-PA secretion.	Epinephrine	156-167	chromosome 20 open reading frame 181	Homo sapiens	16-20
8388699-1	1993	In this paper it has been shown that increase in intracellular cAMP by epinephrine or its analogue dibutyryl cAMP (Bt2cAMP) abolishes in a dose-dependent manner the protein kinase C (PKC)-mediated respiratory burst in polymorphonuclear leukocytes.	Epinephrine	71-82	proline rich transmembrane protein 2	Homo sapiens	165-181
8484015-0	1993	Epidermal growth factor interferes with the effect of adrenaline on glucose production and on hepatic lipase secretion in rat hepatocytes.	Epinephrine	54-64	epidermal growth factor like 1	Rattus norvegicus	0-23
8484015-2	1993	EGF did not modulate glucose release, urea production or hepatic lipase secretion, but interfered with the stimulatory effect of adrenaline on both glucose and urea production and also with the inhibitory effect of this hormone on hepatic lipase secretion.	Epinephrine	129-139	epidermal growth factor like 1	Rattus norvegicus	0-3
8484015-4	1993	While the effect of EGF interfering with the action of adrenaline on glucose release was potentiated in the absence of extracellular calcium, the effect on the inhibition of hepatic lipase secretion was abolished.	Epinephrine	55-65	epidermal growth factor like 1	Rattus norvegicus	20-23
8402396-4	1993	The local infusions (1 min, 0.5 mL/min) of ET-1, in doses of 0.01, 0.1, and 1.0 microgram/mL, resulted in a dose-dependent increase in epinephrine secretion, rising from an initial basal value of 6.9 +/- 1.4 ng.min-1 x g-1 to maximum values of 7.6 +/- 1.5, 81.1 +/- 38.3*, and 680.9 +/- 107.6* ng.min-1 x g-1 (*p &lt; 0.05, n = 7), respectively.	Epinephrine	135-146	endothelin 1	Canis lupus familiaris	43-47
8402396-7	1993	Following the initial peak observed during infusion with the highest dose of ET-1, the output of both epinephrine and norepinephrine remained significantly elevated over a period of 30 min.	Epinephrine	102-113	endothelin 1	Canis lupus familiaris	77-81
8388699-1	1993	In this paper it has been shown that increase in intracellular cAMP by epinephrine or its analogue dibutyryl cAMP (Bt2cAMP) abolishes in a dose-dependent manner the protein kinase C (PKC)-mediated respiratory burst in polymorphonuclear leukocytes.	Epinephrine	71-82	proline rich transmembrane protein 2	Homo sapiens	183-186
8440112-14	1993	Mean end-tidal PCO2 levels were lower after high-dose epinephrine (15 +/- 2 vs. 20 +/- 2 mm Hg; p &lt; .05) but not after standard dose epinephrine (19 +/- 2 vs. 20 +/- 2 mm Hg).	Epinephrine	54-65	PCO2	Sus scrofa	15-19
8473003-7	1993	In the substantia nigra of rats fed 10 ppm T-2, epinephrine increased after 7 days and norepinephrine decreased after 14 days, when compared with controls.	Epinephrine	48-59	brachyury 2	Rattus norvegicus	43-46
8477950-3	1993	In the presence of 16.7 mM D-glucose, however, epinephrine lowered both 86Rb and 45Ca outflow, this coinciding with suppression of insulin release.	Epinephrine	47-58	insulin	Homo sapiens	131-138
7684600-4	1993	Surprisingly, the platelets that contained phosphorylated rap1B were found to respond fully to activation by a wide variety of stimuli: aggregation upon stimulation by collagen, phorbol ester, vasopressin, ADP, epinephrine, and ATP-secretion from dense granules induced by collagen, thrombin-receptor activating peptide, vasopressin and phorbol ester were unchanged as compared to control.	Epinephrine	211-222	RAP1B, member of RAS oncogene family	Homo sapiens	58-63
7763492-3	1993	The mode of action of this compound was suggested to be different from that of a known NGF inducer, epinephrine, as inducing activities of fellutamide A and epinephrine were additive when they were admixed at the concentration which gave saturation in its respective activity.	Epinephrine	100-111	nerve growth factor	Rattus norvegicus	87-90
8102271-5	1993	The results demonstrated that the endothelin-1 level of the incubation medium was elevated when: 1) the incubation time was lengthened; 2) the incubation medium was more acidic; 3) the aortic strips were incubated with a stimulant, such as thrombin and epinephrine; and 4) the endothelial cells on the aortic strips were intact.	Epinephrine	253-264	endothelin 1	Canis lupus familiaris	34-46
8492301-1	1993	The effects of transition metals on nonenzymatic and ceruloplasmin catalyzed epinephrine oxidation were investigated by studying rates of epinephrine oxidation in purified buffers and in the presence of metal chelating agents.	Epinephrine	77-88	ceruloplasmin	Homo sapiens	53-66
8492301-3	1993	Epinephrine was oxidized rapidly in sodium chloride prepared with tap water (1.20 +/- 0.12 nmoles/min) or in deionized water (0.40 +/- 0.80 nmoles/min), but this oxidation was prevented by the addition of Desferal, a potent metal chelating agent.	Epinephrine	0-11	nuclear RNA export factor 1	Homo sapiens	66-69
8492301-4	1993	Epinephrine oxidation was enhanced upon the addition of ceruloplasmin, and this oxidation rate could be slowed, but not eliminated, by the addition of Desferal.	Epinephrine	0-11	ceruloplasmin	Homo sapiens	56-69
8492301-8	1993	Oxygen consumption studies of ceruloplasmin catalyzed epinephrine oxidation showed that copper was a better promoter of epinephrine oxidation than was iron, suggesting that ceruloplasmin-catalyzed epinephrine oxidation results from adventitious copper bound to the purified enzyme.	Epinephrine	54-65	ceruloplasmin	Homo sapiens	30-43
8492301-8	1993	Oxygen consumption studies of ceruloplasmin catalyzed epinephrine oxidation showed that copper was a better promoter of epinephrine oxidation than was iron, suggesting that ceruloplasmin-catalyzed epinephrine oxidation results from adventitious copper bound to the purified enzyme.	Epinephrine	120-131	ceruloplasmin	Homo sapiens	173-186
8492301-8	1993	Oxygen consumption studies of ceruloplasmin catalyzed epinephrine oxidation showed that copper was a better promoter of epinephrine oxidation than was iron, suggesting that ceruloplasmin-catalyzed epinephrine oxidation results from adventitious copper bound to the purified enzyme.	Epinephrine	120-131	ceruloplasmin	Homo sapiens	173-186
8382265-5	1993	FTX or nitrendipine reduced adrenaline and noradrenaline release by approximately 80 and 70%, respectively, but both substances together abolished the K(+)-evoked catecholamine release, as measured by HPLC.	Epinephrine	28-38	FTX transcript, XIST regulator	Homo sapiens	0-3
8381422-4	1993	Prolonged (t1/2 of 5-15 min) pretreatment of cells with okadaic acid caused an inhibition of epinephrine-stimulated cAMP accumulation, which was characterized by a 2-3-fold increase in the EC50 for the response to epinephrine.	Epinephrine	93-104	brachyury, T-box transcription factor T	Mus musculus	11-23
8381422-4	1993	Prolonged (t1/2 of 5-15 min) pretreatment of cells with okadaic acid caused an inhibition of epinephrine-stimulated cAMP accumulation, which was characterized by a 2-3-fold increase in the EC50 for the response to epinephrine.	Epinephrine	214-225	brachyury, T-box transcription factor T	Mus musculus	11-23
8043787-0	1993	[The blocking effect of adrenaline on the thyroid-stimulating effect of vasopressin in rats].	Epinephrine	24-34	arginine vasopressin	Rattus norvegicus	72-83
8425666-0	1993	Effects of epinephrine on insulin secretion and action in humans.	Epinephrine	11-22	insulin	Homo sapiens	26-33
8443032-8	1993	Adrenaline markedly increased platelet aggregability in vivo as measured by filtragometry and elevated levels of beta TG in plasma.	Epinephrine	0-10	pro-platelet basic protein	Homo sapiens	113-120
8427580-0	1993	The effect of epinephrine on the intracellular free calcium of parent and Ki-ras-transfected NIH3T3 cells.	Epinephrine	14-25	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	74-80
8427580-1	1993	Here we describe differences in the formation of the epinephrine-induced Ca2+ transients between parent and Ki-ras-transformed NIH3T3 fibroblasts.	Epinephrine	53-64	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	108-114
7678199-5	1993	In the presence of 10 microM adrenaline, galanin had no effect on membrane potential, electrical activity and 86Rb efflux.	Epinephrine	29-39	galanin and GMAP prepropeptide	Mus musculus	41-48
15278500-6	1993	Similarly, total norepinephrine and epinephrine also increased at the end of PCB, while total dopamine did not change.	Epinephrine	20-31	pyruvate carboxylase	Homo sapiens	77-80
8432288-3	1993	In both normal and heart failure patients, NPY-Li-decreased (296 +/- 73 to 233 +/- 63 pg.ml-1 and 652 +/- 36 to 516 +/- 25 pg.ml-1 (P &lt; 0.01) respectively) in response to standing, whereas catecholamines increased in both groups (norepinephrine 203 +/- 73 to 507 +/- 165 pg.ml-1 and 493 +/- 197 to 813 +/- 336 pg.ml-1 (P &lt; 0.001) respectively and epinephrine 23 +/- 12 to 38 +/- 12 pg.ml-1 and 46 +/- 19 to 62 +/- 28 pg.ml-1 (P &lt; 0.001) respectively).	Epinephrine	236-247	neuropeptide Y	Homo sapiens	43-46
8425246-2	1993	Treatment with epinephrine, calcium chloride, sodium bicarbonate, and furosemide reduced K+ to 6.5 mEq.L-1 within 30 min and myocardial performance was enhanced with amrinone and cardiac rhythm was controlled with A-V segmental pacing.	Epinephrine	15-26	immunoglobulin kappa variable 1-16	Homo sapiens	103-106
8433561-4	1993	We tested the hypothesis that the infusion of physiologic doses of insulin prevents fasting hyperkalemia in hemodialysis patients, both by a direct stimulation of extrarenal potassium disposal, as well as by augmenting the potassium-lowering effect of epinephrine.	Epinephrine	252-263	insulin	Homo sapiens	67-74
8433561-11	1993	Epinephrine did not significantly change the plasma potassium during fasting alone (+0.05 +/- 0.09 mmol/liter, P = 0.59), whereas it lowered the potassium significantly (-0.16 +/- 0.04 mmol/liter, P = 0.003) when the subjects were receiving insulin with glucose.	Epinephrine	0-11	insulin	Homo sapiens	241-248
8433522-4	1993	Analysis of transgenic mice indicated that the additional expression of human PNMT in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggested that norepinephrine-producing cells normally possess the fundamental machinery required for the synthesis of epinephrine except for the PNMT expression.	Epinephrine	89-100	phenylethanolamine N-methyltransferase	Homo sapiens	78-82
8231631-6	1993	Co-incubation of 0.1 microM epinephrine with 0.8 or 3.1 microgram/ml THC significantly stimulated lactate secretion when compared to epinephrine or THC alone, while only the high THC dose increased transferrin secretion.	Epinephrine	28-39	transferrin	Rattus norvegicus	198-209
8433522-4	1993	Analysis of transgenic mice indicated that the additional expression of human PNMT in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggested that norepinephrine-producing cells normally possess the fundamental machinery required for the synthesis of epinephrine except for the PNMT expression.	Epinephrine	148-159	phenylethanolamine N-methyltransferase	Homo sapiens	78-82
8437548-7	1993	PMI revealed a significant correlation (r = 0.792, p &lt; 0.001) with daily urinary epinephrine excretion in the immediate postoperative period (up to the 3rd day).	Epinephrine	84-95	transmembrane protein 11	Homo sapiens	0-3
1472089-2	1992	An increase in the activities of hexokinase and citrate synthase and a reduction in that of glucose-6-phosphate dehydrogenase was found in resident, inflammatory and activated macrophages incubated for 1 hr in the presence of epinephrine.	Epinephrine	226-237	citrate synthase	Rattus norvegicus	48-64
1334095-5	1992	After 30 min of agonist exposure, alpha 2C10 and alpha 2C2 displayed desensitization characterized by rightward shifts in the curves for epinephrine-mediated inhibition of adenylyl cyclase (EC50 = alpha 2C10, 0.24 +/- 0.02 microM increasing to 1.1 +/- 0.1 microM; alpha 2C2, 1.3 +/- 0.3 increasing to 2.6 +/- 0.3 microM).	Epinephrine	137-148	adrenoceptor alpha 2A	Homo sapiens	34-44
21043754-5	1993	On the other hand Trovati et al(4) found reduced platelet aggregation responses to ADP, PAF, epinephrine, collagen and arachidonate in the presence of 40 microU/ml insulin.	Epinephrine	93-104	insulin	Homo sapiens	164-171
8446743-6	1993	During infusion of E, arterial plasma epinephrine levels increased 10-fold, which induced significant increases in heart rate, plasma insulin, and glucose levels, and decreases in mean arterial pressure (MAP) and diastolic pressure (DAP).	Epinephrine	38-49	insulin	Homo sapiens	134-141
8498061-0	1993	[The cooperative effect of hydrocortisone, adrenaline, and high density lipoproteins in regulating the activity of multiple forms of liver hexokinase].	Epinephrine	43-53	hexokinase 1	Homo sapiens	139-150
8498061-1	1993	High density lipoproteins (HDL) were shown to modulate the effect of hydrocortisone and adrenaline on activity of hexokinase in surviving liver tissue slices.	Epinephrine	88-98	hexokinase 1	Homo sapiens	114-124
1337630-3	1992	Infusion of adrenaline, a mixed alpha- and beta-adrenoceptor agonist, increased platelet aggregability in vivo markedly, as measured by ex vivo filtragometry and plasma beta-thromboglobulin levels.	Epinephrine	12-22	pro-platelet basic protein	Homo sapiens	169-189
1336310-8	1992	Further evidence that Gi function is intact in DOCA-NaCl animals is that epinephrine (via alpha 2-adrenoceptor stimulation) inhibited VP-stimulated cAMP accumulation to a similar degree in DOCA-NaCl and control rats (86 and 76%, respectively).	Epinephrine	73-84	arginine vasopressin	Rattus norvegicus	134-136
1472089-2	1992	An increase in the activities of hexokinase and citrate synthase and a reduction in that of glucose-6-phosphate dehydrogenase was found in resident, inflammatory and activated macrophages incubated for 1 hr in the presence of epinephrine.	Epinephrine	226-237	glucose-6-phosphate dehydrogenase	Rattus norvegicus	92-125
1483400-4	1992	Adrenaline, cortisone, and glucagon levels may be increased by stress or food or inhalant allergies, further elevating insulin levels.	Epinephrine	0-10	insulin	Homo sapiens	119-126
1360339-0	1992	Epinephrine augments von Willebrand factor-dependent shear-induced platelet aggregation.	Epinephrine	0-11	von Willebrand factor	Homo sapiens	21-42
1360339-10	1992	The monoclonal antibody NMC-4 against vWF, which was shown to inhibit its binding to GP Ib, completely abolished SIPA under high shear force, even in the presence of epinephrine.	Epinephrine	166-177	von Willebrand factor	Homo sapiens	38-41
1360339-12	1992	CONCLUSIONS: Our findings suggest that epinephrine is the agonist that enhances SIPA mediated by vWF through its specific receptor.	Epinephrine	39-50	von Willebrand factor	Homo sapiens	97-100
1335470-0	1992	Regulation of adrenal steroidogenesis by adrenaline: expression of cytochrome P450 genes.	Epinephrine	41-51	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	78-82
1282602-0	1992	Differential effect of selective beta 1 and nonselective beta-adrenoceptor blockade on epinephrine and atropine response in normal humans.	Epinephrine	87-98	adrenoceptor beta 1	Homo sapiens	33-74
1336886-11	1992	It is suggested that supplementation with epinephrine during CPR may be unnecessary and the levels reached may be deleterious.	Epinephrine	42-53	cytochrome p450 oxidoreductase	Homo sapiens	61-64
1443116-2	1992	After a control period, epinephrine was infused at rates of 0.2 and 0.4 nmol.kg-1 x min-1.	Epinephrine	24-35	CD59 molecule (CD59 blood group)	Homo sapiens	84-89
1452113-0	1992	Insulin modulation of chronotropic response to Adrenaline in diabetic dogs.	Epinephrine	47-57	insulin	Canis lupus familiaris	0-7
1360208-3	1992	Since keratinocytes in the human epidermis, and in cell cultures, express a high density of beta-2-adrenoceptors, and this signal transduction system regulates intracellular calcium homeostasis, it can be concluded that epinephrine production in the epidermis activates calcium transport via the beta-2-adrenoceptor system.	Epinephrine	220-231	adrenoceptor beta 2	Homo sapiens	92-111
1425612-2	1992	Adrenaline was administered at five infusion rates (0.01-0.2 micrograms kg-1 min-1) in an escalating sequence to eight volunteers.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	77-82
1335470-5	1992	Incubation of the cells with 10 mumol adrenaline/l for 1-24 h produced a biphasic time-course with a half-maximal stimulation after about 5-6 h. Maximal stimulation with ACTH (100 nmol/l) caused different accumulations of the four mRNAs: P450sec mRNA increased twice as much and P450(17 alpha) mRNA six times as much as the accumulation of P450c21 mRNA and P450(11 beta) mRNA, which was about ten-fold over basal values.	Epinephrine	38-48	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	238-242
1335470-5	1992	Incubation of the cells with 10 mumol adrenaline/l for 1-24 h produced a biphasic time-course with a half-maximal stimulation after about 5-6 h. Maximal stimulation with ACTH (100 nmol/l) caused different accumulations of the four mRNAs: P450sec mRNA increased twice as much and P450(17 alpha) mRNA six times as much as the accumulation of P450c21 mRNA and P450(11 beta) mRNA, which was about ten-fold over basal values.	Epinephrine	38-48	steroid 21-hydroxylase	Bos taurus	340-347
1335470-5	1992	Incubation of the cells with 10 mumol adrenaline/l for 1-24 h produced a biphasic time-course with a half-maximal stimulation after about 5-6 h. Maximal stimulation with ACTH (100 nmol/l) caused different accumulations of the four mRNAs: P450sec mRNA increased twice as much and P450(17 alpha) mRNA six times as much as the accumulation of P450c21 mRNA and P450(11 beta) mRNA, which was about ten-fold over basal values.	Epinephrine	38-48	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	279-283
1470191-12	1992	An insulin induced hypoglycemia was performed resulting in adrenergic symptoms of hypoglycemia and a subnormal increase of epinephrine.	Epinephrine	123-134	insulin	Homo sapiens	3-10
1283841-0	1992	Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs.	Epinephrine	53-64	beta-2 adrenergic receptor	Canis lupus familiaris	10-40
1384357-9	1992	The response to gastrin was dose dependent between concentrations of 10(-11) and 10(-8) M. In contrast, in the mast cell-enriched SCEF, basal release was higher and gastrin was without effect; however, concanavalin A stimulated and epinephrine inhibited histamine release indicating that histamine-release mechanisms were intact in this fraction.	Epinephrine	232-243	gastrin	Canis lupus familiaris	16-23
1332659-4	1992	Epinephrine alone increased steady-state Ca2+i to 53 +/- 18% (n = 21) of that observed with carbachol.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	41-52
1333965-9	1992	Acute sympathetic activation by adrenaline infusion, short-term exercise, or psychological stress also causes a selective increase in circulating CD56+ or CD57+ lymphocytes which are rich in beta-adrenergic receptors.	Epinephrine	32-42	beta-1,3-glucuronyltransferase 1	Homo sapiens	155-159
1520705-5	1992	Angiotensin II was much more effective than vasopressin or epinephrine in inducing proto-oncogene expression which suggests that angiotensin II receptors may exert actions in addition to those shared with the receptors for the other calcium-mobilizing hormones.	Epinephrine	59-70	angiotensinogen	Rattus norvegicus	129-143
1406302-0	1992	Epinephrine directly antagonizes insulin-mediated activation of glucose uptake and inhibition of free fatty acid release in forearm tissues.	Epinephrine	0-11	insulin	Homo sapiens	33-40
1406302-1	1992	To determine whether the anti-insulin effect of epinephrine is due to a direct antagonism on target tissues or is mediated by indirect mechanisms (systemic substrate and/or hormone changes), insulin and epinephrine were infused intrabrachially in five normal volunteers using the forearm perfusion technique.	Epinephrine	48-59	insulin	Homo sapiens	30-37
1406302-2	1992	Insulin (2.5 mU/min) was infused alone for 90 minutes and in combination with epinephrine (25 ng/min) for an additional 90 minutes, so as to increase the local concentrations of these hormones to physiological levels (60 to 75 microU/mL and 200 to 250 pg/mL for insulin and epinephrine, respectively).	Epinephrine	274-285	insulin	Homo sapiens	0-7
1406302-5	1992	Addition of epinephrine completely abolished the insulin effect on FGU, which returned to its preinfusion value (0.7 +/- 0.2).	Epinephrine	12-23	insulin	Homo sapiens	49-56
1406302-8	1992	Epinephrine addition reverted insulin suppression of FFR, which returned to values slightly above baseline (2.06 +/- 0.47 mumol.L-1.min-1; P less than .05 v insulin alone).	Epinephrine	0-11	insulin	Homo sapiens	30-37
1406302-8	1992	Epinephrine addition reverted insulin suppression of FFR, which returned to values slightly above baseline (2.06 +/- 0.47 mumol.L-1.min-1; P less than .05 v insulin alone).	Epinephrine	0-11	insulin	Homo sapiens	157-164
1406302-9	1992	The data demonstrate that epinephrine is able to antagonize directly insulin action on forearm tissues with respect to both stimulation of glucose uptake and inhibition of FFA mobilization.	Epinephrine	26-37	insulin	Homo sapiens	69-76
1520873-7	1992	LAMP-2 surface expression was minimal in response to platelet stimulation by weak agonists such as epinephrine and ADP.	Epinephrine	99-110	lysosomal associated membrane protein 2	Homo sapiens	0-6
1483768-2	1992	Examination of resting and exercising data from our prior studies at sea level and on Pikes Peak indicated that blood epinephrine concentrations either showed little change (from sea level) or rose early in altitude exposure and then declined with acclimatization.	Epinephrine	118-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	69-72
1483768-2	1992	Examination of resting and exercising data from our prior studies at sea level and on Pikes Peak indicated that blood epinephrine concentrations either showed little change (from sea level) or rose early in altitude exposure and then declined with acclimatization.	Epinephrine	118-129	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	179-182
1331754-4	1992	The endogenous catecholamines epinephrine (EPI) and norepinephrine (NE) were found to have low affinities (micromolar) for the beta 3AR of both species.	Epinephrine	30-41	adrenoceptor beta 3	Homo sapiens	127-135
1331754-4	1992	The endogenous catecholamines epinephrine (EPI) and norepinephrine (NE) were found to have low affinities (micromolar) for the beta 3AR of both species.	Epinephrine	43-46	adrenoceptor beta 3	Homo sapiens	127-135
1382421-3	1992	Using three in vitro models we observed these two compounds had inhibitory effects on cytochrome C reduction by ferrous iron, by ferrous iron accelerated by an unsaturated fatty acid or by epinephrine.	Epinephrine	189-200	cytochrome c, somatic	Homo sapiens	86-98
1530625-0	1992	Epinephrine administration stimulates GLUT4 translocation but reduces glucose transport in muscle.	Epinephrine	0-11	solute carrier family 2 member 4	Rattus norvegicus	38-43
1530625-4	1992	Translocation of the insulin-regulatable glucose transporter (GLUT4) in the epinephrine-injected animals was confirmed by the marked increments in the GLUT-4 in the plasma membranes and their concomitant reduction in the intracellular membranes.	Epinephrine	76-87	solute carrier family 2 member 4	Rattus norvegicus	62-67
1530625-4	1992	Translocation of the insulin-regulatable glucose transporter (GLUT4) in the epinephrine-injected animals was confirmed by the marked increments in the GLUT-4 in the plasma membranes and their concomitant reduction in the intracellular membranes.	Epinephrine	76-87	solute carrier family 2 member 4	Rattus norvegicus	151-157
1530625-5	1992	We speculate a) that it is epinephrine which translocated GLUT4 via a cAMP-linked pathway, and b) that the intrinsic activity reductions are caused either by the glycation of the transporter by the persistent hyperglycemia and/or by epinephrine via the phosphorylation of the GLUT4 transporter protein in muscle.	Epinephrine	27-38	solute carrier family 2 member 4	Rattus norvegicus	58-63
1530625-5	1992	We speculate a) that it is epinephrine which translocated GLUT4 via a cAMP-linked pathway, and b) that the intrinsic activity reductions are caused either by the glycation of the transporter by the persistent hyperglycemia and/or by epinephrine via the phosphorylation of the GLUT4 transporter protein in muscle.	Epinephrine	27-38	solute carrier family 2 member 4	Rattus norvegicus	276-281
1415526-1	1992	Besides exerting its own lipolytic effect, growth hormone (GH) has been reported to potentiate the lipolytic response of adipose tissue to epinephrine.	Epinephrine	139-150	growth hormone 1	Homo sapiens	43-57
1329524-9	1992	Both IL-1 alpha and IL-1 beta significantly increased (P less than 0.05) epinephrine levels after a 24-h incubation period compared with media-treated controls.	Epinephrine	73-84	interleukin 1 alpha	Rattus norvegicus	5-15
1329524-9	1992	Both IL-1 alpha and IL-1 beta significantly increased (P less than 0.05) epinephrine levels after a 24-h incubation period compared with media-treated controls.	Epinephrine	73-84	interleukin 1 beta	Rattus norvegicus	20-29
1415526-1	1992	Besides exerting its own lipolytic effect, growth hormone (GH) has been reported to potentiate the lipolytic response of adipose tissue to epinephrine.	Epinephrine	139-150	growth hormone 1	Homo sapiens	59-61
1415526-2	1992	It was thought interesting to find out whether long-term recombinant human growth hormone (rhGH) administration modifies epinephrine-induced lipolysis in isolated adipocytes of GH-deficient adults.	Epinephrine	121-132	growth hormone 1	Homo sapiens	75-89
1391364-6	1992	Higher doses of epinephrine for CPR seem to be recommendable only after prolonged cardiac arrest and/or during prolonged resuscitation.	Epinephrine	16-27	cytochrome p450 oxidoreductase	Homo sapiens	32-35
1425954-6	1992	Moreover, endothelin-1 inhibited serotonergic amplification of epinephrine-induced aggregation of platelets.	Epinephrine	63-74	endothelin 1	Homo sapiens	10-22
1327833-1	1992	We investigated the beta 2-adrenoceptor-mediated effects of atrial and ventricular effective refractory period (ERP), SA node pacemaker activity, and AV conductivity induced by sympathetic nerve stimulation or epinephrine infusion in anesthetized dogs.	Epinephrine	210-221	beta-2 adrenergic receptor	Canis lupus familiaris	20-39
1327833-2	1992	A beta 2-adrenoceptor antagonist, ICI 118,551 up to 100 micrograms/kg, i.v., inhibited the positive chronotropic and dromotropic responses to sympathetic stimulation but did not shorten the atrial or ventricular ERP, ICI 118,551 also attenuated the positive chronotropic and dromotropic responses and the shortening of atrial ERP in response to epinephrine but not the shortening of ventricular ERP.	Epinephrine	345-356	beta-2 adrenergic receptor	Canis lupus familiaris	2-21
1514727-0	1992	Comparison of intravenous and intranasal administration of epinephrine during CPR in a canine model.	Epinephrine	59-70	cytochrome p450 oxidoreductase	Canis lupus familiaris	78-81
1514727-1	1992	STUDY OBJECTIVES: Epinephrine improves coronary perfusion pressure during CPR.	Epinephrine	18-29	cytochrome p450 oxidoreductase	Canis lupus familiaris	74-77
1514727-2	1992	However, administration of epinephrine during CPR may be delayed or omitted if IV or endotracheal access is not established.	Epinephrine	27-38	cytochrome p450 oxidoreductase	Canis lupus familiaris	46-49
1514727-3	1992	Therefore, the objective of this study was to determine if intranasal administration of epinephrine during CPR would provide an alternate route of drug administration that is readily accessible and requires no special technical skills.	Epinephrine	88-99	cytochrome p450 oxidoreductase	Canis lupus familiaris	107-110
1514727-9	1992	Epinephrine was administered at two minutes into CPR.	Epinephrine	0-11	cytochrome p450 oxidoreductase	Canis lupus familiaris	49-52
1514727-16	1992	Therefore, the nasal route for administration of epinephrine appears to be an acceptable alternate method of drug delivery during CPR and compares favorably with standard IV therapy in the canine model.	Epinephrine	49-60	cytochrome p450 oxidoreductase	Canis lupus familiaris	130-133
1357543-4	1992	[Arg8] Vasopressin (AVP) caused a concentration-dependent (EC50 = 0.49 +/- 0.03 nM) inhibition of the extent to which epinephrine formed a high affinity complex with the alpha 1-adrenoceptor; antagonist binding was unaffected by AVP.	Epinephrine	118-129	arginine vasopressin	Rattus norvegicus	20-23
1357543-4	1992	[Arg8] Vasopressin (AVP) caused a concentration-dependent (EC50 = 0.49 +/- 0.03 nM) inhibition of the extent to which epinephrine formed a high affinity complex with the alpha 1-adrenoceptor; antagonist binding was unaffected by AVP.	Epinephrine	118-129	arginine vasopressin	Rattus norvegicus	229-232
1354941-4	1992	Epinephrine (greater than or equal to 50 nM) and clonidine (greater than or equal to 1 microM) markedly decreased AVP-induced cAMP levels in both IMCD segments.	Epinephrine	0-11	arginine vasopressin	Rattus norvegicus	114-117
1354941-7	1992	In isolated perfused terminal IMCDs, epinephrine inhibited AVP-stimulated urea permeability.	Epinephrine	37-48	arginine vasopressin	Rattus norvegicus	59-62
1325509-4	1992	Plasma NPY-li levels were also correlated with norepinephrine levels only in hypertensive rats, but were correlated with epinephrine levels only in normotensive animals.	Epinephrine	50-61	neuropeptide Y	Rattus norvegicus	7-10
1514604-6	1992	We conclude that epinephrine"s ketogenic effect in humans is primarily the result of its lipolytic effect, is accompanied by a significantly increased rate of ketone body interconversion, is manifest largely as an increase in plasma beta-hydroxybutyrate appearance at high plasma epinephrine values, and is not limited by portal insulin at post-absorptive levels.	Epinephrine	17-28	insulin	Homo sapiens	329-336
1514599-0	1992	Effects of epinephrine on insulin-mediated glucose uptake in whole body and leg muscle in humans: role of blood flow.	Epinephrine	11-22	insulin	Homo sapiens	26-33
1379475-6	1992	However, the second phase of aggregation induced by epinephrine was significantly inhibited by 1.0 ng/ml G-CSF.	Epinephrine	52-63	colony stimulating factor 3	Homo sapiens	105-110
1511338-3	1992	D-amphetamine and arecoline blocked the amnestic effect of beta-endorphin administered into the amygdala but it required higher doses for CCK-8, epinephrine and naloxone to block the amnestic effect of beta-endorphin.	Epinephrine	145-156	pro-opiomelanocortin-alpha	Mus musculus	59-73
1511338-4	1992	The effects of CCK-8, epinephrine and naloxone showed a differential ability to block amnesia induced by beta-endorphin intraventricularly with epinephrine and naloxone preventing amnesia but CCK-8 not improving retention.	Epinephrine	22-33	pro-opiomelanocortin-alpha	Mus musculus	105-119
1511338-4	1992	The effects of CCK-8, epinephrine and naloxone showed a differential ability to block amnesia induced by beta-endorphin intraventricularly with epinephrine and naloxone preventing amnesia but CCK-8 not improving retention.	Epinephrine	144-155	pro-opiomelanocortin-alpha	Mus musculus	105-119
1311009-1	1992	In the present investigation insulin-induced hypoglycemia was used as a powerful stimulus to rapidly release epinephrine from the adrenal medulla.	Epinephrine	109-120	insulin	Homo sapiens	29-36
1321952-0	1992	Beta-adrenergic receptor levels and function after growth of S49 lymphoma cells in low concentrations of epinephrine.	Epinephrine	105-116	adrenergic receptor, beta 1	Mus musculus	0-24
1407001-1	1992	The uptake and subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) of dopamine, adrenaline, isoprenaline and noradrenaline in isolated perfused lungs of rats has been examined.	Epinephrine	117-127	catechol-O-methyltransferase	Rattus norvegicus	70-74
1407001-1	1992	The uptake and subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) of dopamine, adrenaline, isoprenaline and noradrenaline in isolated perfused lungs of rats has been examined.	Epinephrine	117-127	monoamine oxidase A	Rattus norvegicus	99-102
1513751-0	1992	Epinephrine-induced pulmonary oedema in rats is inhibited by corticotropin-releasing factor.	Epinephrine	0-11	corticotropin releasing hormone	Rattus norvegicus	61-91
1639699-4	1992	Epinephrine, atropine, lidocaine, bretylium, and naloxone remain important drugs for consideration in CPR in most animals with cardiac arrest.	Epinephrine	0-11	cytochrome p450 oxidoreductase	Homo sapiens	102-105
1524760-0	1992	The influence of captopril on the epinephrine response to insulin-induced hypoglycemia in humans.	Epinephrine	34-45	insulin	Homo sapiens	58-65
1524760-7	1992	The increase in plasma epinephrine was lower after insulin and captopril compared to after insulin and placebo.	Epinephrine	23-34	insulin	Homo sapiens	51-58
1524760-9	1992	Thus, when the generation of angiotensin II was blocked by captopril the insulin-induced rise in epinephrine and norepinephrine was blunted.	Epinephrine	97-108	angiotensinogen	Homo sapiens	29-43
1524760-9	1992	Thus, when the generation of angiotensin II was blocked by captopril the insulin-induced rise in epinephrine and norepinephrine was blunted.	Epinephrine	97-108	insulin	Homo sapiens	73-80
1593033-3	1992	During epinephrine infusion, active and total t-PA levels increased linearly with the plasma epinephrine concentration (respective slopes [+/- SEM] of 0.062 +/- 0.003 and 0.076 +/- 0.003 pmol/ng epinephrine).	Epinephrine	7-18	plasminogen activator, tissue type	Homo sapiens	46-50
1593033-3	1992	During epinephrine infusion, active and total t-PA levels increased linearly with the plasma epinephrine concentration (respective slopes [+/- SEM] of 0.062 +/- 0.003 and 0.076 +/- 0.003 pmol/ng epinephrine).	Epinephrine	93-104	plasminogen activator, tissue type	Homo sapiens	46-50
1593033-3	1992	During epinephrine infusion, active and total t-PA levels increased linearly with the plasma epinephrine concentration (respective slopes [+/- SEM] of 0.062 +/- 0.003 and 0.076 +/- 0.003 pmol/ng epinephrine).	Epinephrine	93-104	plasminogen activator, tissue type	Homo sapiens	46-50
1593033-4	1992	During exercise, t-PA levels did not increase until plasma epinephrine levels increased, after which both active and total t-PA levels again increased linearly with the plasma epinephrine concentration, but at twice the rate observed with epinephrine infusion (0.131 +/- 0.005 and 0.147 +/- 0.005 pmol/ng, respectively).	Epinephrine	176-187	plasminogen activator, tissue type	Homo sapiens	123-127
1593033-4	1992	During exercise, t-PA levels did not increase until plasma epinephrine levels increased, after which both active and total t-PA levels again increased linearly with the plasma epinephrine concentration, but at twice the rate observed with epinephrine infusion (0.131 +/- 0.005 and 0.147 +/- 0.005 pmol/ng, respectively).	Epinephrine	176-187	plasminogen activator, tissue type	Homo sapiens	123-127
1593033-5	1992	The t-PA level in blood was directly proportional to the plasma epinephrine concentration during both exercise and epinephrine infusion, suggesting that epinephrine release during exercise stimulates t-PA secretion.	Epinephrine	64-75	plasminogen activator, tissue type	Homo sapiens	4-8
1593033-5	1992	The t-PA level in blood was directly proportional to the plasma epinephrine concentration during both exercise and epinephrine infusion, suggesting that epinephrine release during exercise stimulates t-PA secretion.	Epinephrine	115-126	plasminogen activator, tissue type	Homo sapiens	4-8
1350291-5	1992	Inhibition of TNF production was observed only if cells were first exposed to adrenaline or isoproterenol at about the same time as to LPS; incubation of THP-1 cells with isoproterenol for 24 h before LPS stimulation dramatically increased response, and prevented suppression of TNF production by a second dose of isoproterenol.	Epinephrine	78-88	tumor necrosis factor	Homo sapiens	14-17
1350291-6	1992	Intracellular cAMP levels were increased by adrenaline and isoproterenol, at concentrations that inhibited TNF production.	Epinephrine	44-54	tumor necrosis factor	Homo sapiens	107-110
1640844-1	1992	The contribution of the basal insulin concentration to the metabolic response to epinephrine was measured in eight, postabsorptive, healthy volunteers before and during epinephrine (0.05 micrograms/kg fat-free mass [FFM] x min) and somatostatin (500 micrograms/h) infusion with and without insulin (0.1 mU/kg body weight [BW] x min) replacement.	Epinephrine	81-92	insulin	Homo sapiens	30-37
1640844-2	1992	At basal plasma insulin concentrations, epinephrine increased oxygen consumption, heart rate, heart work, hepatic glucose production, glycogen breakdown in liver and muscle, and glucose oxidation, and the arterial plasma concentrations of glucose, lactate, and free fatty acids.	Epinephrine	40-51	insulin	Homo sapiens	16-23
1640844-4	1992	We conclude that epinephrine-induced thermogenesis is partially inhibited by basal plasma insulin concentrations.	Epinephrine	17-28	insulin	Homo sapiens	90-97
1320721-1	1992	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis.	Epinephrine	90-101	phenylethanolamine-N-methyltransferase	Mus musculus	0-38
1320721-1	1992	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the conversion of norepinephrine to epinephrine, the last step of catecholamine biosynthesis.	Epinephrine	90-101	phenylethanolamine-N-methyltransferase	Mus musculus	40-44
1572308-1	1992	We previously reported that the injection of neostigmine, an inhibitor of acetylcholinesterase, into the third cerebral ventricle of fasted rats produced hyperglycemia associated with the secretion of epinephrine and norepinephrine.	Epinephrine	201-212	acetylcholinesterase	Rattus norvegicus	74-94
1569157-7	1992	In contrast, the insulin-antagonistic effect of adrenaline was persistent throughout the 4 h of the study and impaired insulin action with 54 +/- 2%.	Epinephrine	48-58	insulin	Homo sapiens	17-24
1569157-10	1992	In contrast, the insulin-antagonistic effect of adrenaline on glucose uptake is persistent for at least 4 h.	Epinephrine	48-58	insulin	Homo sapiens	17-24
1604044-2	1992	Some anesthetic agents are known to modify plasma levels of catecholamines; moreover NPY is co-released with noradrenaline or adrenaline under certain conditions.	Epinephrine	112-122	neuropeptide Y	Rattus norvegicus	85-88
1352364-4	1992	In the dorsal medulla, the baroreceptor afferents with substance P converge to the adrenaline-neuropeptide Y (NPY) interneurons located in the dorsal strip of the nucleus tractus solitarius (NTS).	Epinephrine	83-93	tachykinin precursor 1	Homo sapiens	55-66
1555188-1	1992	The superoxide dismutase (SOD) activities in normal and tumor breast tissues from 14 human females were determined by the epinephrine autoxidation assay.	Epinephrine	122-133	superoxide dismutase 1	Homo sapiens	4-24
1555188-1	1992	The superoxide dismutase (SOD) activities in normal and tumor breast tissues from 14 human females were determined by the epinephrine autoxidation assay.	Epinephrine	122-133	superoxide dismutase 1	Homo sapiens	26-29
1611701-1	1992	Thyrotropin-releasing hormone (TRH) improved mean arterial pressure (MAP) and myocardial contractility (dp/dtmax, -dp/dtmax, Vpm, and Vmax) and increased plasma epinephrine levels significantly at 10 min after TRH treatment in rabbits following shock, but the effects of TRH on MAP and myocardial contractility disappeared in reserpinized rabbits (4 mg/kg, 24 hr pre-treatment, iv).	Epinephrine	161-172	thyrotropin releasing hormone	Oryctolagus cuniculus	0-29
1611701-1	1992	Thyrotropin-releasing hormone (TRH) improved mean arterial pressure (MAP) and myocardial contractility (dp/dtmax, -dp/dtmax, Vpm, and Vmax) and increased plasma epinephrine levels significantly at 10 min after TRH treatment in rabbits following shock, but the effects of TRH on MAP and myocardial contractility disappeared in reserpinized rabbits (4 mg/kg, 24 hr pre-treatment, iv).	Epinephrine	161-172	thyrotropin releasing hormone	Oryctolagus cuniculus	31-34
1611701-4	1992	These results suggest that the antishock effects of TRH are related to adrenergic systems, perhaps acting on the sympathomedullary system to secrete epinephrine and sensitize the beta receptors, but not alpha receptors.	Epinephrine	149-160	thyrotropin releasing hormone	Oryctolagus cuniculus	52-55
1568974-0	1992	Effect of 5 wk of detraining on epinephrine response to insulin-induced hypoglycemia in athletes.	Epinephrine	32-43	insulin	Homo sapiens	56-63
1542654-1	1992	Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Mus musculus	65-103
1542654-1	1992	Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Mus musculus	105-109
1542654-1	1992	Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	145-156	phenylethanolamine-N-methyltransferase	Mus musculus	65-103
1542654-1	1992	Epinephrine-producing cells are characterized by the presence of phenylethanolamine N-methyltransferase (PNMT), which catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	145-156	phenylethanolamine-N-methyltransferase	Mus musculus	105-109
1542654-4	1992	Analysis of catecholamines in the various tissues showed that the expression of human PNMT in transgenic mice induced the appearance of epinephrine in sympathetic ganglion and dramatic changes in norepinephrine and epinephrine levels in brain, adrenal gland, and blood.	Epinephrine	136-147	phenylethanolamine N-methyltransferase	Homo sapiens	86-90
1542654-4	1992	Analysis of catecholamines in the various tissues showed that the expression of human PNMT in transgenic mice induced the appearance of epinephrine in sympathetic ganglion and dramatic changes in norepinephrine and epinephrine levels in brain, adrenal gland, and blood.	Epinephrine	199-210	phenylethanolamine N-methyltransferase	Homo sapiens	86-90
1311555-6	1992	(2) Inhibition of adenylate cyclase by thrombin, adrenaline or collagen fibres could be abolished in the presence of guanosine 5"-[beta-thio]diphosphate; half-maximal inhibition was obtained at about 100 microM for the inhibitory action of thrombin, and at about 500 microM for that of either adrenaline or collagen.	Epinephrine	49-59	coagulation factor II, thrombin	Homo sapiens	240-248
1311555-6	1992	(2) Inhibition of adenylate cyclase by thrombin, adrenaline or collagen fibres could be abolished in the presence of guanosine 5"-[beta-thio]diphosphate; half-maximal inhibition was obtained at about 100 microM for the inhibitory action of thrombin, and at about 500 microM for that of either adrenaline or collagen.	Epinephrine	293-303	coagulation factor II, thrombin	Homo sapiens	39-47
1547916-0	1992	The effects of different plasma insulin concentrations on lipolytic and ketogenic responses to epinephrine in normal and type 1 (insulin-dependent) diabetic humans.	Epinephrine	95-106	insulin	Homo sapiens	32-39
1547916-1	1992	This study was performed to verify: (1) the ability of different insulin concentrations to restrict the lipolytic and ketogenic responses to exogenous epinephrine administration; (2) whether the ability of insulin to suppress the lipolytic and ketogenic responses during epinephrine administration is impaired in Type 1 (insulin-dependent) diabetic patients.	Epinephrine	151-162	insulin	Homo sapiens	65-72
1547916-12	1992	In conclusion this study shows that at low insulin levels Type 1 diabetic patients show an increased ketogenic response to epinephrine, despite their normal nonesterified fatty acid response.	Epinephrine	123-134	insulin	Homo sapiens	43-50
1547916-13	1992	Instead, high insulin levels are able to restrict the ketogenic response to epinephrine in both normal and Type 1 diabetic subjects, although there is a still detectable lipolytic response in the latter.	Epinephrine	76-87	insulin	Homo sapiens	14-21
1547916-15	1992	Plasma insulin levels in Type 1 diabetic patients are a major determinant of the metabolic response to epinephrine.	Epinephrine	103-114	insulin	Homo sapiens	7-14
1547928-4	1992	Insulin has also an indirect effect on vascular permeability during hypoglycaemia, which is mediated by the increase in plasma adrenaline.	Epinephrine	127-137	insulin	Homo sapiens	0-7
1569376-8	1992	Although epinephrine inhibited [35S]methionine incorporation into LPL in control rat adipocytes, there was essentially no effect in hypothyroid rat cells.	Epinephrine	9-20	lipoprotein lipase	Rattus norvegicus	66-69
1352549-3	1992	Also, in chick heart cell membranes the relative ability of agonists to displace ICYP produced a profile typical of beta-1 adrenergic receptors with a rank order of potency or efficacy of: isoproterenol greater than epinephrine = norephinephrine.	Epinephrine	216-227	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	116-122
1352549-7	1992	For ICYP/agonist competition binding experiments the relative ability to displace ICYP was isoproterenol greater than epinephrine = norepinephrine, a profile typical of beta-1 adrenergic receptors.	Epinephrine	118-129	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	169-175
1407001-2	1992	In lung preparations in which COMT and MAO were inhibited, the uptake of 3H-labelled dopamine, (-)-adrenaline and (-)-noradrenaline, but not (+/-)-isoprenaline, was reduced by cocaine (10 or 100 mumol/l).	Epinephrine	95-109	catechol-O-methyltransferase	Rattus norvegicus	30-34
1407001-2	1992	In lung preparations in which COMT and MAO were inhibited, the uptake of 3H-labelled dopamine, (-)-adrenaline and (-)-noradrenaline, but not (+/-)-isoprenaline, was reduced by cocaine (10 or 100 mumol/l).	Epinephrine	95-109	monoamine oxidase A	Rattus norvegicus	39-42
1407001-7	1992	In lung preparations in which only MAO was inhibited, the rank order of COMT activity for O-methylation of the amines was dopamine much much greater than noradrenaline greater than or equal to adrenaline (kCOMT values: 4.98 min-1, 0.357 min-1 and 0.234 min-1, respectively).	Epinephrine	157-167	catechol-O-methyltransferase	Rattus norvegicus	72-76
1407001-8	1992	If dopamine or adrenaline are perfused through the pulmonary circulation in isolated lungs of the rat, they are taken up and then metabolized by COMT and MAO, as also occurs for noradrenaline.	Epinephrine	15-25	catechol-O-methyltransferase	Rattus norvegicus	145-149
1407001-8	1992	If dopamine or adrenaline are perfused through the pulmonary circulation in isolated lungs of the rat, they are taken up and then metabolized by COMT and MAO, as also occurs for noradrenaline.	Epinephrine	15-25	monoamine oxidase A	Rattus norvegicus	154-157
1303174-0	1992	Genetic linkage of the human gene for phenylethanolamine N-methyltransferase (PNMT), the adrenaline-synthesizing enzyme, to DNA markers on chromosome 17q21-q22.	Epinephrine	89-99	phenylethanolamine N-methyltransferase	Homo sapiens	38-76
1303174-0	1992	Genetic linkage of the human gene for phenylethanolamine N-methyltransferase (PNMT), the adrenaline-synthesizing enzyme, to DNA markers on chromosome 17q21-q22.	Epinephrine	89-99	phenylethanolamine N-methyltransferase	Homo sapiens	78-82
1303174-1	1992	We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine.	Epinephrine	191-202	phenylethanolamine N-methyltransferase	Homo sapiens	67-105
1303174-1	1992	We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine.	Epinephrine	191-202	phenylethanolamine N-methyltransferase	Homo sapiens	107-111
1303174-1	1992	We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine.	Epinephrine	204-214	phenylethanolamine N-methyltransferase	Homo sapiens	67-105
1303174-1	1992	We have determined the genetic location of the human gene encoding phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme of the catecholamine pathway catalyzing the synthesis of epinephrine (adrenaline) from norepinephrine.	Epinephrine	204-214	phenylethanolamine N-methyltransferase	Homo sapiens	107-111
1593033-5	1992	The t-PA level in blood was directly proportional to the plasma epinephrine concentration during both exercise and epinephrine infusion, suggesting that epinephrine release during exercise stimulates t-PA secretion.	Epinephrine	115-126	plasminogen activator, tissue type	Homo sapiens	4-8
1593033-7	1992	It is concluded that approximately 50% of the increase in t-PA during exercise is due to stimulated release of t-PA by epinephrine.	Epinephrine	119-130	plasminogen activator, tissue type	Homo sapiens	58-62
1593033-7	1992	It is concluded that approximately 50% of the increase in t-PA during exercise is due to stimulated release of t-PA by epinephrine.	Epinephrine	119-130	plasminogen activator, tissue type	Homo sapiens	111-115
1350291-9	1992	Adrenaline may be an important endogenous regulator of TNF production in sepsis.	Epinephrine	0-10	tumor necrosis factor	Homo sapiens	55-58
21554614-17	1992	Therefore, the data suggest that an endogenous alpha(1) ligand, such as norepinephrine (or epinephrine), is required to maintain a high level of LHRH gene expression in the ovariectomized rat.	Epinephrine	75-86	gonadotropin releasing hormone 1	Rattus norvegicus	145-149
1640854-1	1992	The aim of this study was to determine the relative roles of changes in glucose-mediated glucose disposal (SG) and insulin sensitivity (SI) on the impairment of glucose disposal caused by epinephrine (EPI) infusion in type I (insulin-dependent) diabetes mellitus (IDDM).	Epinephrine	188-199	insulin	Homo sapiens	115-122
1349606-8	1992	In alpha 2C-AR transfectants expressing higher receptor densities (650-1,200 fmol/mg), epinephrine inhibited the effect of forskolin by 30 +/- 3.2%.	Epinephrine	87-98	adrenoceptor alpha 2C	Homo sapiens	3-14
1384161-4	1992	LK-4 inhibits platelet aggregation induced by ADP, epinephrine, collagen and thrombin, suggesting reactivity at or near the fibrinogen binding site on GPIIIa.	Epinephrine	51-62	ceramide kinase	Homo sapiens	0-4
1350723-4	1992	This finding indicated that the interaction of individual receptors with GTP-binding protein (G) occurs on a time scale which is greater than the mean lifetime of the epinephrine-receptor complex; during this period of interaction (an "encounter"), a receptor can change its occupancy state in the presence of a high binding frequency agonist such as epinephrine.	Epinephrine	167-178	developmentally regulated GTP binding protein 1	Mus musculus	73-92
1613427-4	1992	In incubations of intact adrenal capsular tissue, VIP (10 mumol/l) caused a significant stimulation of aldosterone secretion, and also induced a significant release of adrenaline into the incubation medium.	Epinephrine	168-178	vasoactive intestinal peptide	Rattus norvegicus	50-53
1613427-6	1992	It is concluded that the effects of VIP on aldosterone, which are only seen when the architecture of the zona glomerulosa is preserved, may be mediated by the local release of adrenaline.	Epinephrine	176-186	vasoactive intestinal peptide	Rattus norvegicus	36-39
1614137-2	1992	PO2 measurements using a double barelled recess type microelectrodes were measured in the optic nerve head of miniature pigs during systemic hyperoxia (100% oxygen breathing) and variations of the systemic blood pressure by intravenous injection of Adrenaline or trinitrine.	Epinephrine	249-259	PO2	Sus scrofa	0-3
1614143-1	1992	PO2 measurements using a double barelled recess type microelectrodes were measured in the optic nerve head of miniature pigs during systemic hyperoxia (100% oxygen breathing) and variations of the systemic blood pressure by intravenous injection of Adrenaline or trinitrine.	Epinephrine	249-259	PO2	Sus scrofa	0-3
1350321-11	1992	In addition, we examined physical and functional coupling of beta 1- and beta 2ARs to Gs using the agonist epinephrine, which also has equal binding affinity for both receptor subtypes.	Epinephrine	107-118	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	61-82
1350321-12	1992	As with isoproterenol, epinephrine was more potent in stimulating adenylyl cyclase and promoted a higher affinity ternary complex for the beta 2AR.	Epinephrine	23-34	adrenoceptor beta 2	Homo sapiens	138-146
1313699-1	1992	Incubation of platelets from normal volunteers, who had not taken any medication at least for 2 weeks, with insulin (200 mu units/ml), resulted in the inhibition of the potentiation of ADP-induced platelet aggregation in the presence of (-)-epinephrine by 50-60% when compared with the control.	Epinephrine	237-252	insulin	Homo sapiens	108-115
1567912-5	1992	(ii) In isolated hepatocytes, secretion of lipoprotein lipase activity was increased by adrenaline, dexamethasone and glucagon but was not affected by epidermal growth factor, insulin or triiodothyronine.	Epinephrine	88-98	lipoprotein lipase	Rattus norvegicus	43-61
1567912-6	1992	On the contrary, secretion of hepatic lipase activity was decreased by adrenaline but was not affected by other hormones.	Epinephrine	71-81	lipase C, hepatic type	Rattus norvegicus	30-44
1567912-8	1992	And (iv), increased secretion of lipoprotein lipase activity was only observed after 3 h of incubation with adrenaline and was blocked by cycloheximide.	Epinephrine	108-118	lipoprotein lipase	Rattus norvegicus	33-51
1313568-0	1992	Epinephrine suppresses rap1B.GAP-activated GTPase activity in human platelets.	Epinephrine	0-11	RAP1B, member of RAS oncogene family	Homo sapiens	23-28
1313568-3	1992	Only epinephrine was found to dramatically decrease not only the rate but also the amount of hydrolysis of rap1B-bound GTP activated by rap1B.GAP.	Epinephrine	5-16	RAP1B, member of RAS oncogene family	Homo sapiens	107-112
1313568-3	1992	Only epinephrine was found to dramatically decrease not only the rate but also the amount of hydrolysis of rap1B-bound GTP activated by rap1B.GAP.	Epinephrine	5-16	RAP1B, member of RAS oncogene family	Homo sapiens	136-141
1313568-5	1992	The suppression of GTPase activity was specific for rap1B.GAP in that ras.GAP- and rap2B.GAP-activated GTPase activity were not affected by epinephrine stimulation.	Epinephrine	140-151	RAP1B, member of RAS oncogene family	Homo sapiens	52-57
1313568-9	1992	Although the migration characteristics upon anion-exchange chromatography of rap1B.GAP and ras.GAP activities were unaffected by epinephrine stimulation, the specific activity of rap1B.GAP was noticeably decreased with 250 and 500 microM epinephrine.	Epinephrine	238-249	RAP1B, member of RAS oncogene family	Homo sapiens	77-82
1313568-9	1992	Although the migration characteristics upon anion-exchange chromatography of rap1B.GAP and ras.GAP activities were unaffected by epinephrine stimulation, the specific activity of rap1B.GAP was noticeably decreased with 250 and 500 microM epinephrine.	Epinephrine	238-249	RAP1B, member of RAS oncogene family	Homo sapiens	179-184
1313568-10	1992	These results suggest a possible role for rap1B and rap1B.GAP in epinephrine-stimulated signal transduction.	Epinephrine	65-76	RAP1B, member of RAS oncogene family	Homo sapiens	42-47
1313568-10	1992	These results suggest a possible role for rap1B and rap1B.GAP in epinephrine-stimulated signal transduction.	Epinephrine	65-76	RAP1B, member of RAS oncogene family	Homo sapiens	52-57
1311318-3	1992	After cells were exposed to epinephrine for 30 min, the ability of the wild type alpha 2AAR to mediate inhibition of forskolin-stimulated adenylyl cyclase was depressed by approximately 78%.	Epinephrine	28-39	adrenoceptor alpha 2A	Homo sapiens	81-91
1349450-3	1992	With the beta 1-selective blockade, epinephrine release was triggered at a significantly higher (p less than 0.02) plasma glucose level (3.5 mmol/l) than it was with placebo (3.0 mmol/l).	Epinephrine	36-47	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	9-15
1542654-5	1992	These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT.	Epinephrine	65-76	phenylethanolamine-N-methyltransferase	Mus musculus	43-47
1542654-5	1992	These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT.	Epinephrine	65-76	phenylethanolamine-N-methyltransferase	Mus musculus	285-289
1542654-5	1992	These results indicate that the additional PNMT expression in norepinephrine-producing cells can convert these cells to the epinephrine phenotype, and suggest that norepinephrine-producing cells normally possess the basic machinery required for the synthesis of epinephrine except for PNMT.	Epinephrine	124-135	phenylethanolamine-N-methyltransferase	Mus musculus	43-47
1542654-6	1992	Thus it appears that the only major difference between norepinephrine- and epinephrine-producing cells is the expression of PNMT.	Epinephrine	58-69	phenylethanolamine-N-methyltransferase	Mus musculus	124-128
1628451-2	1992	In control subjects, insulin-induced hypoglycemia resulted in marked increases in plasma epinephrine and norepinephrine levels.	Epinephrine	89-100	insulin	Homo sapiens	21-28
1312014-4	1992	A 24 h pre-incubation with either CRH, epinephrine or nor-epinephrine increased the [125I]IL-1 alpha binding sites in the AtT-20 cells and conversely, a similar pre-incubation with either dexamethasone or tumour necrosis factor-alpha (TNF alpha) decreased them without affecting the affinity of the receptors in either case.	Epinephrine	39-50	interleukin 1 alpha	Mus musculus	90-100
1312014-4	1992	A 24 h pre-incubation with either CRH, epinephrine or nor-epinephrine increased the [125I]IL-1 alpha binding sites in the AtT-20 cells and conversely, a similar pre-incubation with either dexamethasone or tumour necrosis factor-alpha (TNF alpha) decreased them without affecting the affinity of the receptors in either case.	Epinephrine	39-50	tumor necrosis factor	Mus musculus	235-244
1577991-1	1992	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species.	Epinephrine	123-134	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
1577991-1	1992	Phenylethanolamine N-methyltransferase (PNMT), the final enzyme in the catecholamine biosynthetic pathway that converts norepinephrine to epinephrine, has been detected in the retinas of various vertebrate species.	Epinephrine	123-134	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
1347200-6	1992	The effects of l-epinephrine were not blocked by the beta-adrenergic antagonist dl-propranolol but were mimicked by the alpha 1-adrenergic agonist methoxamine.	Epinephrine	15-28	adrenoceptor alpha 1D	Homo sapiens	120-127
1347200-7	1992	Prazosin, an alpha 1-adrenergic antagonist, and pertussis toxin (PTX) blocked the effects of l-epinephrine and methoxamine.	Epinephrine	93-106	adrenoceptor alpha 1D	Homo sapiens	13-20
1375628-6	1992	The SCC response to bradykinin and acetylcholine are attenuated with prior stimulation by 10 microM-adrenaline.	Epinephrine	100-110	kininogen 1	Canis lupus familiaris	20-30
1311009-2	1992	Insulin injection raised epinephrine 16-fold and doubled norepinephrine plasma levels.	Epinephrine	25-36	insulin	Homo sapiens	0-7
1310018-0	1992	Pituitary adenylate cyclase activating polypeptide provokes cultured rat chromaffin cells to secrete adrenaline.	Epinephrine	101-111	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
1613985-7	1992	Moreover, endothelin-1 inhibited serotonergic amplification of epinephrine-induced aggregation of platelets.	Epinephrine	63-74	endothelin 1	Homo sapiens	10-22
1310018-1	1992	Pituitary adenylate cyclase activating polypeptide (PACAP) provoked the rat chromaffin cells to secrete adrenaline.	Epinephrine	104-114	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
1310018-1	1992	Pituitary adenylate cyclase activating polypeptide (PACAP) provoked the rat chromaffin cells to secrete adrenaline.	Epinephrine	104-114	adenylate cyclase activating polypeptide 1	Rattus norvegicus	52-57
1310018-2	1992	Within 20 min, the amount of adrenaline secreted by PACAP (10(-8) M) was as much as that caused by acetylcholine (10(-4) M).	Epinephrine	29-39	adenylate cyclase activating polypeptide 1	Rattus norvegicus	52-57
1310018-3	1992	PACAP, but not acetylcholine, induced a long-term (over 120 min) increase in secretion of adrenaline.	Epinephrine	90-100	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-5
1310018-6	1992	These results suggest that PACAP has an important role in stimulating secretion of adrenaline in the adrenal medulla.	Epinephrine	83-93	adenylate cyclase activating polypeptide 1	Rattus norvegicus	27-32
1375201-2	1992	C5a-stimulated superoxide production was markedly inhibited by adenylate cyclase activators, and the order of potency was PGE1 greater than isoproterenol greater than epinephrine greater than PGF2 alpha, which correlated with intracellular cAMP levels.	Epinephrine	167-178	complement C5a receptor 1	Homo sapiens	0-3
1345888-2	1992	Epinephrine was found to be markedly thermogenic: at infusion rates of 0.01, 0.03, and 0.1 microgram.min-1.kg fat-free mass-1 resting energy expenditure (REE) increased by 8%, 16%, and 29%, respectively; in addition, a dose-dependent increase in heart rate was observed.	Epinephrine	0-11	adhesion G protein-coupled receptor V1	Homo sapiens	119-125
1309427-1	1992	Previous studies have shown that binding sites for fibrinogen on platelets stimulated with platelet-activating factor (PAF), adenosine diphosphate or epinephrine rapidly close in the absence of fibrinogen.	Epinephrine	150-161	fibrinogen beta chain	Homo sapiens	51-61
1286482-0	1992	Effect of pacing on epinephrine-stimulated atrial natriuretic factor release.	Epinephrine	20-31	natriuretic peptide A	Rattus norvegicus	43-68
1286482-1	1992	Previous in vitro studies showed that epinephrine stimulation can induce atrial natriuretic factor (ANF) release only form the right atrium but not from the left.	Epinephrine	38-49	natriuretic peptide A	Rattus norvegicus	73-98
1286482-1	1992	Previous in vitro studies showed that epinephrine stimulation can induce atrial natriuretic factor (ANF) release only form the right atrium but not from the left.	Epinephrine	38-49	natriuretic peptide A	Rattus norvegicus	100-103
1286482-3	1992	In vitro studies were done in isolated left and right rat atria to determine if pacing can induce the left atria to release ANF during epinephrine stimulation.	Epinephrine	135-146	natriuretic peptide A	Rattus norvegicus	124-127
1286482-5	1992	Epinephrine increased ANF release in the right atria (from 6.3 +/- 0.8 to 10.8 +/- 0.9 pg/min/mg), but not in the unpaced left atria (4.2 +/- 0.4 and 4.2 +/- 0.3 pg/min/mg).	Epinephrine	0-11	natriuretic peptide A	Rattus norvegicus	22-25
1286482-6	1992	However, when the atria were paced, ANF release rose in both the left (from 6.2 +/- 0.5 to 11.5 +/- 1.4 pg/min/mg) and right (from 8.4 +/- 1.15 to 16.6 +/- 1.8 pg/min/mg) atria with epinephrine addition.	Epinephrine	182-193	natriuretic peptide A	Rattus norvegicus	36-39
1286482-7	1992	These results suggest that atrial contraction and tension play an important role in epinephrine-stimulated ANF release.	Epinephrine	84-95	natriuretic peptide A	Rattus norvegicus	107-110
1577042-3	1992	However, if platelet aggregation were induced by combinations of the agonists (including combinations of ADP with either adrenaline or platelet-activating factor (PAF), adrenaline with PAF, and collagen with ADP), the anti-aggregant effects of aspirin, dipyridamole, and cavinton were significantly reduced.	Epinephrine	169-179	PCNA clamp associated factor	Homo sapiens	185-188
1628875-10	1992	Thus, galanine, somatostatin and adrenaline, which inhibit insulin release, increase K+ conductance by a G protein-dependent mechanism; both peptides were reported to open ATP-sensitive K+ channels in insulin-secreting cell line RINm5F.	Epinephrine	33-43	insulin	Homo sapiens	59-66
1628875-10	1992	Thus, galanine, somatostatin and adrenaline, which inhibit insulin release, increase K+ conductance by a G protein-dependent mechanism; both peptides were reported to open ATP-sensitive K+ channels in insulin-secreting cell line RINm5F.	Epinephrine	33-43	insulin	Homo sapiens	201-208
1738372-0	1992	Epinephrine inhibits lipoprotein lipase gene expression in rat adipocytes through multiple steps in posttranscriptional processing.	Epinephrine	0-11	lipoprotein lipase	Rattus norvegicus	21-39
1347153-7	1992	The facilitatory effects of isoprenaline (0.1 mumol/l) and adrenaline (0.1 mumol/l) were blocked by the selective beta 2-adrenoceptor antagonist ICI 118551 (0.1 mumol/l) but not by the selective beta 1-adrenoceptor antagonist atenolol (0.3 mumol/l).	Epinephrine	59-69	adrenoceptor beta 2	Rattus norvegicus	114-133
1347153-7	1992	The facilitatory effects of isoprenaline (0.1 mumol/l) and adrenaline (0.1 mumol/l) were blocked by the selective beta 2-adrenoceptor antagonist ICI 118551 (0.1 mumol/l) but not by the selective beta 1-adrenoceptor antagonist atenolol (0.3 mumol/l).	Epinephrine	59-69	adrenoceptor beta 1	Rattus norvegicus	195-214
1576090-8	1992	The norepinephrine/epinephrine ratio decreases as epinephrine, prolactin, renin and fatty acids rise.	Epinephrine	7-18	renin	Homo sapiens	74-79
1576090-8	1992	The norepinephrine/epinephrine ratio decreases as epinephrine, prolactin, renin and fatty acids rise.	Epinephrine	19-30	renin	Homo sapiens	74-79
1738372-7	1992	Cells exposed to epinephrine during the chase demonstrated a decrease in LPL secretion into the medium as well as a decrease in LPL degradation.	Epinephrine	17-28	lipoprotein lipase	Rattus norvegicus	73-76
1738372-7	1992	Cells exposed to epinephrine during the chase demonstrated a decrease in LPL secretion into the medium as well as a decrease in LPL degradation.	Epinephrine	17-28	lipoprotein lipase	Rattus norvegicus	128-131
1738372-9	1992	Thus, epinephrine had multiple effects on adipocyte LPL.	Epinephrine	6-17	lipoprotein lipase	Rattus norvegicus	52-55
1738372-3	1992	Epinephrine yielded a dose-dependent decrease in LPL activity; heparin-releasable LPL activity was reduced to 66% of control values after exposure to 10(-5) M epinephrine for 2 h. However, there was no effect of epinephrine on LPL immunoreactive mass, as measured by enzyme-linked immunosorbent assay.	Epinephrine	0-11	lipoprotein lipase	Rattus norvegicus	49-52
1738372-3	1992	Epinephrine yielded a dose-dependent decrease in LPL activity; heparin-releasable LPL activity was reduced to 66% of control values after exposure to 10(-5) M epinephrine for 2 h. However, there was no effect of epinephrine on LPL immunoreactive mass, as measured by enzyme-linked immunosorbent assay.	Epinephrine	0-11	lipoprotein lipase	Rattus norvegicus	82-85
1738372-3	1992	Epinephrine yielded a dose-dependent decrease in LPL activity; heparin-releasable LPL activity was reduced to 66% of control values after exposure to 10(-5) M epinephrine for 2 h. However, there was no effect of epinephrine on LPL immunoreactive mass, as measured by enzyme-linked immunosorbent assay.	Epinephrine	0-11	lipoprotein lipase	Rattus norvegicus	82-85
1738372-3	1992	Epinephrine yielded a dose-dependent decrease in LPL activity; heparin-releasable LPL activity was reduced to 66% of control values after exposure to 10(-5) M epinephrine for 2 h. However, there was no effect of epinephrine on LPL immunoreactive mass, as measured by enzyme-linked immunosorbent assay.	Epinephrine	159-170	lipoprotein lipase	Rattus norvegicus	49-52
1738372-3	1992	Epinephrine yielded a dose-dependent decrease in LPL activity; heparin-releasable LPL activity was reduced to 66% of control values after exposure to 10(-5) M epinephrine for 2 h. However, there was no effect of epinephrine on LPL immunoreactive mass, as measured by enzyme-linked immunosorbent assay.	Epinephrine	159-170	lipoprotein lipase	Rattus norvegicus	82-85
1738372-3	1992	Epinephrine yielded a dose-dependent decrease in LPL activity; heparin-releasable LPL activity was reduced to 66% of control values after exposure to 10(-5) M epinephrine for 2 h. However, there was no effect of epinephrine on LPL immunoreactive mass, as measured by enzyme-linked immunosorbent assay.	Epinephrine	159-170	lipoprotein lipase	Rattus norvegicus	82-85
1348126-4	1992	Epinephrine, oxymetazoline, clonidine, and guanabenz inhibited VP-induced cAMP formation in rat inner medullary collecting tubule cells with IC50s ranging from 10 to 30 nM.	Epinephrine	0-11	arginine vasopressin	Rattus norvegicus	63-65
1387933-0	1992	Effects of adrenaline infusion on serum thromboxane B2 and plasma beta-thromboglobulin levels in hypertensive and normotensive subjects.	Epinephrine	11-21	pro-platelet basic protein	Homo sapiens	66-86
1631566-10	1992	The thrombin-inhibiting activity of these antibodies could partially be reversed by pretreating antibody-coated platelets with epinephrine immediately followed by stimulation with thrombin.	Epinephrine	127-138	coagulation factor II, thrombin	Homo sapiens	4-12
1348126-6	1992	Similarly, epinephrine inhibited VP-induced cAMP accumulation in cortical collecting tubules dissected from rat kidneys but not from dog or rabbit kidneys.	Epinephrine	11-22	arginine vasopressin	Rattus norvegicus	33-35
1383507-1	1992	We have shown that growth of S49 WT mouse lymphoma cells for 24 hr in 3 nM epinephrine produced very significant desensitization of subsequent cellular cAMP responses to challenges with higher concentrations of epinephrine.	Epinephrine	75-86	cathelicidin antimicrobial peptide	Mus musculus	152-156
1383507-1	1992	We have shown that growth of S49 WT mouse lymphoma cells for 24 hr in 3 nM epinephrine produced very significant desensitization of subsequent cellular cAMP responses to challenges with higher concentrations of epinephrine.	Epinephrine	211-222	cathelicidin antimicrobial peptide	Mus musculus	152-156
1363262-3	1992	Both beta 1- and beta 2-adrenoceptors couple to adenylate cyclase and mediate positive inotropic effects of isoprenaline and adrenaline on isolated, electrically driven cardiac preparations.	Epinephrine	125-135	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	5-11
1383507-5	1992	That is, when the effects of epinephrine on cellular cAMP levels were measured in LTT or control L-WT beta 2AR cells little desensitization was apparent.	Epinephrine	29-40	cathelicidin antimicrobial peptide	Mus musculus	53-57
1383507-5	1992	That is, when the effects of epinephrine on cellular cAMP levels were measured in LTT or control L-WT beta 2AR cells little desensitization was apparent.	Epinephrine	29-40	adrenergic receptor, beta 2	Mus musculus	102-110
1383507-6	1992	Further, cellular cAMP excursions in response to even very high concentrations of epinephrine were very small in control L-WT beta 2AR cells as compared to control S49 WT cells.	Epinephrine	82-93	cathelicidin antimicrobial peptide	Mus musculus	18-22
1383507-6	1992	Further, cellular cAMP excursions in response to even very high concentrations of epinephrine were very small in control L-WT beta 2AR cells as compared to control S49 WT cells.	Epinephrine	82-93	adrenergic receptor, beta 2	Mus musculus	126-134
1383507-10	1992	Further, when cellular cAMP levels in intact L-WT beta 2AR cells were raised above a threshold by treatment with 0.5 microM forskolin and 2 mM IBMX with the epinephrine challenge, the effect of LLT became obvious in the intact cell system.	Epinephrine	157-168	cathelicidin antimicrobial peptide	Mus musculus	23-27
1343147-6	1992	Adrenaline tests identify fine disturbances in endocrine regulation and considerably raise the predictive value of such indicators as ACTH, insulin, TTH, T3, T4 and calcitonin.	Epinephrine	0-10	proopiomelanocortin	Homo sapiens	134-138
1343147-6	1992	Adrenaline tests identify fine disturbances in endocrine regulation and considerably raise the predictive value of such indicators as ACTH, insulin, TTH, T3, T4 and calcitonin.	Epinephrine	0-10	insulin	Homo sapiens	140-147
1363262-3	1992	Both beta 1- and beta 2-adrenoceptors couple to adenylate cyclase and mediate positive inotropic effects of isoprenaline and adrenaline on isolated, electrically driven cardiac preparations.	Epinephrine	125-135	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-23
1363262-7	1992	However, in situations of stress, when large amounts of adrenaline (acting at both beta 1- and beta 2-adrenoceptors with the same affinity) are released from the adrenal medulla, activation of cardiac beta 2-adrenoceptors may contribute to an additional increase in heart rate and/or contractility.	Epinephrine	56-66	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	83-101
1363262-7	1992	However, in situations of stress, when large amounts of adrenaline (acting at both beta 1- and beta 2-adrenoceptors with the same affinity) are released from the adrenal medulla, activation of cardiac beta 2-adrenoceptors may contribute to an additional increase in heart rate and/or contractility.	Epinephrine	56-66	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	95-101
1659234-6	1991	In vitro studies demonstrated that epinephrine caused a dose-dependent reduction in vasopressin-stimulated cAMP levels in cortical collecting tubules from the rat (50% effective concentration 32 nM) but not from the dog.	Epinephrine	35-46	arginine vasopressin	Rattus norvegicus	84-95
1683610-6	1991	Aggregatory responses to epinephrine may be enhanced by propranolol in vitro, because of unopposed alpha 2-stimulation (beta 2-stimulation attenuates aggregation).	Epinephrine	25-36	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	120-126
1805636-2	1991	Although these procedures are done under general anesthesia, lidocaine is often used as a vehicle for epinephrine to aid hemostasis during the procedure.	Epinephrine	102-113	activation induced cytidine deaminase	Homo sapiens	117-120
1777837-0	1991	Route of administration of adrenaline for the treatment of anaphylactic reactions to bee or wasp stings.	Epinephrine	27-37	WASP actin nucleation promoting factor	Homo sapiens	92-96
1665747-11	1991	(-)-Adrenaline and (-)-noradrenaline showed dissimilar order of affinities for the three alpha2-adrenoceptors.	Epinephrine	0-14	adrenoceptor alpha 2A	Rattus norvegicus	89-109
1660516-0	1991	Adrenaline stimulates cholesterol side-chain cleavage cytochrome P450 mRNA accumulation in bovine adrenocortical cells.	Epinephrine	0-10	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	65-69
1935790-7	1991	Adrenaline, but not insulin, glucagon, dexamethasone, epidermal growth factor, or T3, decreased the amount of hepatic endothelial lipase activity released by hepatocytes isolated from fed rats.	Epinephrine	0-10	lipase G, endothelial type	Rattus norvegicus	118-136
1682135-1	1991	The sites of action for somatostatin and epinephrine to inhibit insulin secretion have been reported to be exclusively in the exocytotic pathway.	Epinephrine	41-52	insulin	Homo sapiens	64-71
1682135-3	1991	We observed that both somatostatin and epinephrine not only inhibit insulin secretion (53 +/- 2% and 50 +/- 2% of control, respectively) but also decrease insulin mRNA levels (54 +/- 5% and 66 +/- 5% of control, respectively) and insulin content in HIT cells (61 +/- 2% and 51 +/- 1% of control, respectively).	Epinephrine	39-50	insulin	Homo sapiens	68-75
1682135-3	1991	We observed that both somatostatin and epinephrine not only inhibit insulin secretion (53 +/- 2% and 50 +/- 2% of control, respectively) but also decrease insulin mRNA levels (54 +/- 5% and 66 +/- 5% of control, respectively) and insulin content in HIT cells (61 +/- 2% and 51 +/- 1% of control, respectively).	Epinephrine	39-50	insulin	Homo sapiens	155-162
1682135-3	1991	We observed that both somatostatin and epinephrine not only inhibit insulin secretion (53 +/- 2% and 50 +/- 2% of control, respectively) but also decrease insulin mRNA levels (54 +/- 5% and 66 +/- 5% of control, respectively) and insulin content in HIT cells (61 +/- 2% and 51 +/- 1% of control, respectively).	Epinephrine	39-50	insulin	Homo sapiens	155-162
1682135-5	1991	These new observations suggest that somatostatin and epinephrine negatively modulate insulin availability through a guanine nucleotide binding protein-mediated step in insulin synthesis before the exocytotic pathway.	Epinephrine	53-64	insulin	Homo sapiens	85-92
1682135-5	1991	These new observations suggest that somatostatin and epinephrine negatively modulate insulin availability through a guanine nucleotide binding protein-mediated step in insulin synthesis before the exocytotic pathway.	Epinephrine	53-64	insulin	Homo sapiens	168-175
1660516-1	1991	The effect of adrenaline on the accumulation of mRNA encoding cholesterol side-chain cleavage cytochrome P450 (P450scc) and cortisol secretion was studied in bovine adrenocortical cells in primary culture.	Epinephrine	14-24	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	105-109
1660516-1	1991	The effect of adrenaline on the accumulation of mRNA encoding cholesterol side-chain cleavage cytochrome P450 (P450scc) and cortisol secretion was studied in bovine adrenocortical cells in primary culture.	Epinephrine	14-24	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	111-118
1660516-2	1991	Treatment of cultured cells with adrenaline resulted in a 2-fold increase in mRNA encoding P-450scc, as revealed by Northern blot analysis.	Epinephrine	33-43	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	91-99
1660516-4	1991	The effect of adrenaline on the expression of P450scc was abolished by the beta-blocker propranolol, while propranolol had no effect on ACTH-induced P450scc mRNA accumulation.	Epinephrine	14-24	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	46-53
1660516-8	1991	It is concluded that the stimulatory action of adrenaline upon cortisol formation requires beta-adrenergic receptors and is due, at least in part, to a cAMP-mediated increases in the accumulation of mRNA encoding P450scc.	Epinephrine	47-57	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	213-220
1928061-9	1991	However, it is important to appreciate that the response to beta 2-adrenoreceptor-mediated internal potassium disposal is heterogeneous as judged by the variable responses to epinephrine infusion.	Epinephrine	175-186	adrenoceptor beta 2	Homo sapiens	60-81
1833961-8	1991	Also, infusion of NPY (10(-9) mol/L) by microdialysis in the A1 area resulted in the reduction of NE concentration; epinephrine and dopamine levels were also decreased.	Epinephrine	116-127	neuropeptide Y	Rattus norvegicus	18-21
1717069-7	1991	When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not.	Epinephrine	24-27	ral guanine nucleotide dissociation stimulator	Homo sapiens	125-129
1682065-1	1991	Treatment with beta 1-selective antagonists causes selective sensitization of isolated strips of human atrial myocardium to the inotropic action of epinephrine and beta 2-agonists but not of norepinephrine.	Epinephrine	148-159	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	15-21
1655647-3	1991	To this end, two strictly standardized mental stress tests were performed in 14 normotensive men during and 1 hour after double-blind infusion of epinephrine (50 ng x kg-1 x min-1) or placebo given in random order.	Epinephrine	146-157	CD59 molecule (CD59 blood group)	Homo sapiens	174-179
32357642-6	1991	Immunohistochemical study revealed that catecholamine-synthesizing enzymes were present in both components of the pheochromocytoma and neuroblastoma group, but phenylethanolamine N-methyltransferase was detectable only in epinephrine-producing tumors.	Epinephrine	222-233	phenylethanolamine N-methyltransferase	Homo sapiens	160-198
1717069-7	1991	When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not.	Epinephrine	24-35	ral guanine nucleotide dissociation stimulator	Homo sapiens	125-129
1717069-7	1991	When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not.	Epinephrine	24-35	selectin P	Homo sapiens	131-138
1934338-8	1991	Epinephrine exposure was found to significantly increase sensitivity, Fth, and Fsat of both types of baroreceptors, with a relatively greater effect on type I sensitivity and on type II Fth and Fsat.	Epinephrine	0-11	ferritin heavy chain 1	Homo sapiens	70-73
1934338-8	1991	Epinephrine exposure was found to significantly increase sensitivity, Fth, and Fsat of both types of baroreceptors, with a relatively greater effect on type I sensitivity and on type II Fth and Fsat.	Epinephrine	0-11	ferritin heavy chain 1	Homo sapiens	186-189
1685012-8	1991	As noradrenaline acts in the human heart solely at beta 1-adrenoceptors, while adrenaline activates both beta 1- and beta 2-adrenoceptors with about the same potency, with increasing posttransplant time (and increasing proportion of beta 2-adrenoceptors) adrenaline may play an important role for regulation of contractility and/or heart rate in heart transplant recipients.	Epinephrine	79-89	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	105-123
1685012-8	1991	As noradrenaline acts in the human heart solely at beta 1-adrenoceptors, while adrenaline activates both beta 1- and beta 2-adrenoceptors with about the same potency, with increasing posttransplant time (and increasing proportion of beta 2-adrenoceptors) adrenaline may play an important role for regulation of contractility and/or heart rate in heart transplant recipients.	Epinephrine	79-89	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-123
1892901-3	1991	Adrenaline, isoprenaline (a beta-adrenergic agonist) and lactate exerted a similar action decreasing Fru(2,6)P2 concentration.	Epinephrine	0-10	zinc finger and BTB domain containing 22	Homo sapiens	101-104
1835988-1	1991	Intrathecal administration of thyrotropin-releasing hormone (TRH) resulted in an increase in plasma epinephrine (E) and glucose levels in conscious rats.	Epinephrine	100-111	thyrotropin releasing hormone	Rattus norvegicus	30-59
1835988-1	1991	Intrathecal administration of thyrotropin-releasing hormone (TRH) resulted in an increase in plasma epinephrine (E) and glucose levels in conscious rats.	Epinephrine	100-111	thyrotropin releasing hormone	Rattus norvegicus	61-64
1922967-2	1991	Submaximal longitudinal muscle relaxation of the histamine-precontracted ileum evoked by rat CGRP (3 nM) or capsaicin (1 microM) was reversed by hCGRP(8-37) (1.5 microM), while that due to adrenaline or neurotensin was not affected.	Epinephrine	189-199	calcitonin-related polypeptide alpha	Rattus norvegicus	93-97
1685514-3	1991	First, superoxide generation from the cells was estimated and the results indicated that the adrenergic agonists, such as isoproterenol, salbutamol, procaterol and epinephrine, inhibited over 70% and 40% of the superoxide generation stimulated by FMLP and serum treated zymosan (STZ), respectively.	Epinephrine	164-175	formyl peptide receptor 1	Homo sapiens	247-251
1685514-5	1991	Isoproterenol and epinephrine decreased the arachidonic acid release only when the cells were activated by FMLP in the presence of merthiolate.	Epinephrine	18-29	formyl peptide receptor 1	Homo sapiens	107-111
1861630-8	1991	The increase in HSL activity by epinephrine, like glycerol release, was potentiated by GH.	Epinephrine	32-43	lipase E, hormone sensitive type	Homo sapiens	16-19
1861630-8	1991	The increase in HSL activity by epinephrine, like glycerol release, was potentiated by GH.	Epinephrine	32-43	growth hormone 1	Homo sapiens	87-89
1861630-10	1991	However, in contrast to the chronic effect of GH, short-term (30-minute) incubation with GH inhibited epinephrine-stimulated glycerol release, a characteristic transient antilipolytic effect of GH.	Epinephrine	102-113	growth hormone 1	Homo sapiens	89-91
1861630-10	1991	However, in contrast to the chronic effect of GH, short-term (30-minute) incubation with GH inhibited epinephrine-stimulated glycerol release, a characteristic transient antilipolytic effect of GH.	Epinephrine	102-113	growth hormone 1	Homo sapiens	89-91
1658894-3	1991	The purpose of this study was to determine if IA or IV volume infusion could augment the effect of epinephrine on CPP during CPR in the canine model.	Epinephrine	99-110	cytochrome p450 oxidoreductase	Canis lupus familiaris	125-128
1683267-5	1991	Inhibition was dose-dependent and restricted to the alpha 2-adrenoceptor mediated aggregation response stimulated by epinephrine (1 microM) or potentiated by subthreshold concentrations of epinephrine (30-300 nM) in the presence of subaggregatory doses of vasopressin (10-30 nM).	Epinephrine	189-200	arginine vasopressin	Homo sapiens	256-267
1677640-2	1991	Dopamine beta-hydroxylase (DBH) deficiency is a genetic disorder in which affected patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the central nervous system or the peripheral autonomic neurons.	Epinephrine	113-124	dopamine beta-hydroxylase	Homo sapiens	0-25
1677640-2	1991	Dopamine beta-hydroxylase (DBH) deficiency is a genetic disorder in which affected patients cannot synthesize norepinephrine, epinephrine, and octopamine in either the central nervous system or the peripheral autonomic neurons.	Epinephrine	113-124	dopamine beta-hydroxylase	Homo sapiens	27-30
1681438-6	1991	These observations suggest that TRH-induced hyperglycemia results from at least two effects: a direct neural effect on the liver including a suppressive effect of epinephrine on insulin secretion (contributing about 79% to the total hyperglycemic effect) and a direct effect of epinephrine on the liver (contributing about 21% to the total hyperglycemic effect).	Epinephrine	163-174	thyrotropin releasing hormone	Rattus norvegicus	32-35
1681438-6	1991	These observations suggest that TRH-induced hyperglycemia results from at least two effects: a direct neural effect on the liver including a suppressive effect of epinephrine on insulin secretion (contributing about 79% to the total hyperglycemic effect) and a direct effect of epinephrine on the liver (contributing about 21% to the total hyperglycemic effect).	Epinephrine	278-289	thyrotropin releasing hormone	Rattus norvegicus	32-35
1685558-14	1991	Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR.	Epinephrine	107-121	adrenoceptor beta 1	Homo sapiens	143-151
1685558-14	1991	Consistent with this finding, around 80% of the adenylyl cyclase stimulation by both (-)-noradrenaline and (-)-adrenaline was mediated through beta 1AR, around 20% through beta 2AR.	Epinephrine	107-121	adrenoceptor beta 2	Homo sapiens	172-180
1685558-17	1991	The positive inotropic effects of (-)-adrenaline were quite variable with regard to beta 1AR and beta 2AR in right ventricular papillary muscles.	Epinephrine	34-48	adrenoceptor beta 1	Homo sapiens	84-92
1685558-17	1991	The positive inotropic effects of (-)-adrenaline were quite variable with regard to beta 1AR and beta 2AR in right ventricular papillary muscles.	Epinephrine	34-48	adrenoceptor beta 2	Homo sapiens	97-105
1685558-19	1991	In 3 out of 17 muscles beta 2AR mediated the same maximum effect of (-)-adrenaline as beta 1AR.	Epinephrine	68-82	adrenoceptor beta 2	Homo sapiens	23-31
1685558-22	1991	One muscle only exhibited beta 1AR-mediated effects of (-)-adrenaline whereas in the other muscle maximal effects could be elicited through beta 2AR.	Epinephrine	55-69	adrenoceptor beta 1	Homo sapiens	26-34
2058661-4	1991	Epinephrine and cortisol responses to hypoglycemia were increased during naloxone plus insulin compared with insulin alone; glucagon responses were unaffected.	Epinephrine	0-11	insulin	Homo sapiens	87-94
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Epinephrine	44-54	adrenoceptor beta 1	Homo sapiens	103-123
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Epinephrine	44-54	adrenoceptor beta 1	Homo sapiens	125-133
1652275-1	1991	Heart rate and force can be increased by noradrenaline and adrenaline through an interaction with both beta 1-adrenoceptors (beta 1AR) and beta 2-adrenoceptors (beta 2 AR).	Epinephrine	44-54	adrenoceptor beta 2	Homo sapiens	161-170
1652300-3	1991	Endothelin-2 (10(-11)-10(-8) M) increased both the force and velocity of contraction in a concentration-dependent manner, giving a maximum response of about 70% of that attainable with histamine or epinephrine.	Epinephrine	198-209	endothelin 2	Homo sapiens	0-12
1885446-5	1991	The increased NK cell activity during exercise and the epinephrine infusion resulted from an increased concentration of NK (CD16+) cells in the peripheral blood.	Epinephrine	55-66	Fc gamma receptor IIIa	Homo sapiens	124-128
1678909-8	1991	This attenuation to a great extent could be ascribed to adrenaline-induced B2-adrenoceptor stimulation, since beta 2-blockade restored the delta arterial pressure/capillary pressure ratio to 20.	Epinephrine	56-66	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	110-116
2035681-1	1991	In the presence of extracellular Ca2+, epinephrine induces a rise in cytoplasmic Ca2+ ([Ca2+]i) that is associated with fibrinogen binding to the platelet surface, platelet aggregation, and enhancement of the thrombin-stimulated [Ca2+]i rise and protein phosphorylation.	Epinephrine	39-50	fibrinogen beta chain	Homo sapiens	120-130
2035681-1	1991	In the presence of extracellular Ca2+, epinephrine induces a rise in cytoplasmic Ca2+ ([Ca2+]i) that is associated with fibrinogen binding to the platelet surface, platelet aggregation, and enhancement of the thrombin-stimulated [Ca2+]i rise and protein phosphorylation.	Epinephrine	39-50	coagulation factor II, thrombin	Homo sapiens	209-217
2035681-2	1991	Whether the [Ca2+]i rise induced by epinephrine results from Ca2+ entry associated with fibrinogen binding to its receptor on the platelet surface, the glycoprotein (gp) IIb-IIIa complex, is unknown.	Epinephrine	36-47	fibrinogen beta chain	Homo sapiens	88-98
1850310-5	1991	Epinephrine caused a dose-related reduction of chemiluminescence, superoxide anion generation, enzyme release (lysozyme and beta-glucuronidase), and adhesion to endothelial cell (EC) monolayers in human PMN activated by N-formyl-methionyl-leucyl-phenyl-alanine (fMLP).	Epinephrine	0-11	glucuronidase beta	Homo sapiens	124-142
1850310-5	1991	Epinephrine caused a dose-related reduction of chemiluminescence, superoxide anion generation, enzyme release (lysozyme and beta-glucuronidase), and adhesion to endothelial cell (EC) monolayers in human PMN activated by N-formyl-methionyl-leucyl-phenyl-alanine (fMLP).	Epinephrine	0-11	formyl peptide receptor 1	Homo sapiens	262-266
1850328-8	1991	Accumulation of [3H]inositol 1-phosphate [( 3H]IP1) in ventricular slices prelabeled with [3H]myo-inositol was increased by epinephrine in a time- and concentration-dependent manner in rat ventricular slices.	Epinephrine	124-135	huntingtin interacting protein 1	Rattus norvegicus	45-50
2065473-0	1991	Potassium, glucose, insulin interrelationships during adrenaline infusion in normotensive and hypertensive humans.	Epinephrine	54-64	insulin	Homo sapiens	20-27
1882084-4	1991	In contrast, oxytocin-induced release of epinephrine (E) showed no significant difference in between the innervated and the denervated glands after 0.5 h of treatment.	Epinephrine	41-52	oxytocin/neurophysin I prepropeptide	Homo sapiens	13-21
1653313-1	1991	The aim of this study was to differentiate between the extent to which surgical stress and the epinephrine in local anesthetic solutions influence serum catecholamine, cAMP, and potassium levels, and contribute to changes in cardiohemodynamic parameters.	Epinephrine	95-106	cathelicidin antimicrobial peptide	Homo sapiens	168-172
1653313-5	1991	The serum cAMP changes correlated with those of epinephrine, whereas the serum potassium levels remained unchanged.	Epinephrine	48-59	cathelicidin antimicrobial peptide	Homo sapiens	10-14
1860230-3	1991	Homogenates of rat heart, which contain the enzymes phenylethanolamine N-methyltransferase (PNMT) and nonspecific N-methyltransferase (NMT), methylate norepinephrine to form epinephrine.	Epinephrine	154-165	phenylethanolamine-N-methyltransferase	Rattus norvegicus	52-90
1860230-9	1991	Dexamethasone did not alter ventricular epinephrine levels but increased levels of both PNMT and catechol-O-methyltransferase, the major catabolic enzyme for epinephrine.	Epinephrine	158-169	phenylethanolamine-N-methyltransferase	Rattus norvegicus	88-92
1860230-9	1991	Dexamethasone did not alter ventricular epinephrine levels but increased levels of both PNMT and catechol-O-methyltransferase, the major catabolic enzyme for epinephrine.	Epinephrine	158-169	catechol-O-methyltransferase	Rattus norvegicus	97-125
2053554-6	1991	When a physiologic dose of epinephrine is infused into essential hypertensive patients, platelet counts, platelet size, and plasma BTG concentrations increase more than in normotensive subjects.	Epinephrine	27-38	pro-platelet basic protein	Homo sapiens	131-134
1829631-2	1991	In concordance with this finding, supernatants from the patients" fibrin clots caused abnormal enhancement of platelet aggregation, ATP secretion, and binding of 125I-fibrinogen to platelets exposed to subthreshold concentrations of ADP or epinephrine.	Epinephrine	240-251	fibrinogen beta chain	Homo sapiens	167-177
1829631-8	1991	In addition, the patients" fibrinogen showed normal polymerization of preformed fibrin monomers, normal sialic acid content, and normal binding to ADP or epinephrine-stimulated platelets.	Epinephrine	154-165	fibrinogen beta chain	Homo sapiens	27-37
1859754-5	1991	infusions of adrenaline (1-5 micrograms min-1).	Epinephrine	13-23	CD59 molecule (CD59 blood group)	Homo sapiens	40-45
1680780-10	1991	Thy 1, 2-positive T-cells were decreased in the blood and increased in the spleen while Lyt 2-positive T-cells were increased in the spleen by adrenaline.	Epinephrine	143-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100	Mus musculus	88-91
1685558-7	1991	In the sinoatrial pacemaker (-)-adrenaline caused positive chronotropic effects through both beta 1AR and beta 2AR while (-)-noradrenaline does so predominantly through beta 1AR.	Epinephrine	28-42	adrenoceptor beta 1	Homo sapiens	93-101
1685558-7	1991	In the sinoatrial pacemaker (-)-adrenaline caused positive chronotropic effects through both beta 1AR and beta 2AR while (-)-noradrenaline does so predominantly through beta 1AR.	Epinephrine	28-42	adrenoceptor beta 2	Homo sapiens	106-114
1685558-8	1991	During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR.	Epinephrine	25-39	adrenoceptor beta 1	Homo sapiens	7-15
1685558-8	1991	During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR.	Epinephrine	25-39	adrenoceptor beta 2	Homo sapiens	83-91
1685558-8	1991	During beta 1AR blockade (-)-adrenaline did cause the same maximum effects through beta 2AR as (-)-noradrenaline did through beta 1AR.	Epinephrine	25-39	adrenoceptor beta 1	Homo sapiens	125-133
1685558-10	1991	In left atria (-)-adrenaline caused positive inotropic effects predominantly through beta 1AR.	Epinephrine	14-28	adrenoceptor beta 1	Homo sapiens	85-93
1685558-11	1991	CGP 20,712 A also uncovered a beta 2AR component at high (-)-adrenaline concentrations comprising one third of the maximum beta 1AR-mediated response.	Epinephrine	61-71	adrenoceptor beta 2	Homo sapiens	30-38
1685558-11	1991	CGP 20,712 A also uncovered a beta 2AR component at high (-)-adrenaline concentrations comprising one third of the maximum beta 1AR-mediated response.	Epinephrine	61-71	adrenoceptor beta 1	Homo sapiens	123-131
1905485-5	1991	Epinephrine treatment increased GPase activity (0.78 +/- 0.03) and decreased GSase activity (0.05 +/- 0.01), which resulted in decreased glycogen content (25.7 +/- 0.9 mumol/g; P less than 0.01).	Epinephrine	0-11	glycogen phosphorylase L	Rattus norvegicus	32-37
1905485-10	1991	In conclusion, these data indicate that glucocorticoid is essential for the effects of epinephrine on GPase activation.	Epinephrine	87-98	glycogen phosphorylase L	Rattus norvegicus	102-107
2042794-4	1991	Human CGRP provoked a transient but significant decrease in systolic and diastolic blood pressure, associated with tachycardia, marked flushing, a significant increase in plasma noradrenaline, adrenaline, and cyclic AMP levels, and a slight, but significant, decrease in serum total calcium.	Epinephrine	181-191	calcitonin related polypeptide alpha	Homo sapiens	6-10
1940021-3	1991	Subsequent inhibition of phenylethanolamine-N-methyltransferase (PNMT) allowed the gradual restoration of dopamine and noradrenaline but not adrenaline, resulting in a greater relative depletion of adrenaline.	Epinephrine	122-132	phenylethanolamine-N-methyltransferase	Rattus norvegicus	25-63
1940021-3	1991	Subsequent inhibition of phenylethanolamine-N-methyltransferase (PNMT) allowed the gradual restoration of dopamine and noradrenaline but not adrenaline, resulting in a greater relative depletion of adrenaline.	Epinephrine	122-132	phenylethanolamine-N-methyltransferase	Rattus norvegicus	65-69
1940021-3	1991	Subsequent inhibition of phenylethanolamine-N-methyltransferase (PNMT) allowed the gradual restoration of dopamine and noradrenaline but not adrenaline, resulting in a greater relative depletion of adrenaline.	Epinephrine	141-151	phenylethanolamine-N-methyltransferase	Rattus norvegicus	25-63
1940021-3	1991	Subsequent inhibition of phenylethanolamine-N-methyltransferase (PNMT) allowed the gradual restoration of dopamine and noradrenaline but not adrenaline, resulting in a greater relative depletion of adrenaline.	Epinephrine	141-151	phenylethanolamine-N-methyltransferase	Rattus norvegicus	65-69
1674642-7	1991	Thus we conclude that sympathochromaffin activation plays a minor role when insulin and glucagon are operative, but a catecholamine, probably epinephrine, becomes critical to the prevention of hypoglycemia during exercise when changes in insulin and glucagon do not occur.	Epinephrine	142-153	insulin	Homo sapiens	238-245
2035626-7	1991	However, since hypoglycemia did not develop during exercise when changes in insulin and glucagon were prevented, an additional counterregulatory factor, such as epinephrine, must be involved in the prevention of hypoglycemia during exercise, at least when the primary factors, insulin and glucagon, are inoperative.	Epinephrine	161-172	insulin	Homo sapiens	277-284
2031819-12	1991	Defining a positive result to a test dose as an increase in HR of greater than 10 beat min-1, the sensitivity of the adrenaline test dose was 83 (5.5)% in the saline group and 91 (3.5)% in the atropine group (ns).	Epinephrine	117-127	CD59 molecule (CD59 blood group)	Homo sapiens	87-92
1679709-4	1991	Inhibition of VIP-stimulated cyclic AMP production by epinephrine and paraaminoclonidine in tissues from both normal and denervated eyes was blocked by the alpha 2-adrenergic antagonist yohimbine but not by the alpha 1-adrenergic antagonist prazosin.	Epinephrine	54-65	VIP peptides	Oryctolagus cuniculus	14-17
1687976-1	1991	In situ hybridization and Northern blot analysis has been used to analyse in some detail the localization and regulation of the messenger molecules adrenaline, noradrenaline and neuropeptide tyrosine (NPY) within cells of the sympathetic nervous system and the adrenal medulla.	Epinephrine	148-158	neuropeptide Y	Homo sapiens	201-204
2033506-1	1991	Previous studies have reported that maximally effective concentrations of the "mixed" alpha and beta adrenoceptor agonists, epinephrine and norepinephrine, cause greater amounts of mucin secretion than the "pure" beta adrenoceptor agonist, isoproterenol, and that this response requires extracellular calcium.	Epinephrine	124-135	solute carrier family 13 member 2	Rattus norvegicus	181-186
1902217-7	1991	Cell stimulation by thrombin, ADP plus epinephrine or phorbol-ester caused up to a 2-fold increase in RET between chromophore-labeled, platelet-bound B1B5, SSA6, and A2A9 (p less than or equal to 0.05), suggesting a change in the separation or orientation of these epitopes within the GP IIb-IIIa complex.	Epinephrine	39-50	coagulation factor II, thrombin	Homo sapiens	20-28
1902217-7	1991	Cell stimulation by thrombin, ADP plus epinephrine or phorbol-ester caused up to a 2-fold increase in RET between chromophore-labeled, platelet-bound B1B5, SSA6, and A2A9 (p less than or equal to 0.05), suggesting a change in the separation or orientation of these epitopes within the GP IIb-IIIa complex.	Epinephrine	39-50	integrin subunit alpha 2b	Homo sapiens	285-291
1717069-7	1991	When the combination of epinephrine and adenosine diphosphate (epi/ADP) was used as a less potent agonist in the presence of RGDS, GMP-140 expression per platelet was less, and while monocyte-platelet conjugates formed, PMN-platelet conjugates did not.	Epinephrine	24-27	selectin P	Homo sapiens	131-138
19215515-0	1991	In vivo Infusion of Adrenaline Stimulates Corticotropin-Releasing Hormone-Producing Neurons when given Centrally but not Distally.	Epinephrine	20-30	corticotropin releasing hormone	Rattus norvegicus	42-73
1672696-4	1991	The results demonstrated that epinephrine and terbutaline (a beta 2 agonist) significantly stimulated gastrin release above basal which could be blocked by the addition of propranolol (beta-adrenergic antagonist).	Epinephrine	30-41	gastrin	Homo sapiens	102-109
1672696-8	1991	The data indicated that adrenaline released from the adrenal medulla and gastrin releasing peptide (the mammalian homolog of bombesin) released from the intrinsic innervation of the stomach interact with respect to the stimulation of gastrin.	Epinephrine	24-34	gastrin releasing peptide	Homo sapiens	125-133
1645362-1	1991	Metabolic events stimulated by epinephrine and norepinephrine in hepatocytes isolated from fetal and early postnatal male rats are largely mediated through the beta 2-adrenergic receptor-/cyclic AMP dependent-system, whereas the same stimuli are transduced through the alpha 1-adrenergic receptor-/phosphatidylinositol dependent-system in hepatocytes isolated from young adult male rats.	Epinephrine	31-42	adrenoceptor beta 2	Rattus norvegicus	160-186
19215515-1	1991	Abstract There is evidence that adrenaline stimulates the release of corticotropin-releasing hormone (CRH-41) from hypothalamic neurons.	Epinephrine	32-42	corticotropin releasing hormone	Rattus norvegicus	69-100
1921215-2	1991	Effect of adrenaline on the ERG and VEP in rabbits].	Epinephrine	10-20	transcriptional regulator ERG	Oryctolagus cuniculus	28-31
19215515-1	1991	Abstract There is evidence that adrenaline stimulates the release of corticotropin-releasing hormone (CRH-41) from hypothalamic neurons.	Epinephrine	32-42	corticotropin releasing hormone	Rattus norvegicus	102-105
19215515-5	1991	Intracerebroventricular or intracerebral adrenaline induced a swift, short-lived (15 min) CRH-41 surge which reached 7 to 10 times the basal level.	Epinephrine	41-51	corticotropin releasing hormone	Rattus norvegicus	90-93
19215515-6	1991	Direct perfusion of the median eminence with adrenaline (around the nerve endings of CRH-41-producing neurons) did not stimulate CRH-41 release and higher amine concentrations even tended to depress the neuropeptide release.	Epinephrine	45-55	corticotropin releasing hormone	Rattus norvegicus	85-88
19215515-7	1991	The stimulatory effect of adrenaline on the corticotropic axis appears, therefore, to be restricted to the central dendro-perikaryal region of CRH-41-producing neurons.	Epinephrine	26-36	corticotropin releasing hormone	Rattus norvegicus	143-146
1996816-0	1991	Plasma concentrations of epinephrine during CPR in the dog.	Epinephrine	25-36	cytochrome p450 oxidoreductase	Canis lupus familiaris	44-47
1711404-2	1991	Antibodies to the enzyme phenylethanolamine-N-methyltransferase (PNMT) were employed to map the distribution of epinephrine-containing axonal profiles in the primate spinal cord.	Epinephrine	112-123	phenylethanolamine N-methyltransferase	Homo sapiens	25-63
1711404-2	1991	Antibodies to the enzyme phenylethanolamine-N-methyltransferase (PNMT) were employed to map the distribution of epinephrine-containing axonal profiles in the primate spinal cord.	Epinephrine	112-123	phenylethanolamine N-methyltransferase	Homo sapiens	65-69
1900669-0	1991	Epinephrine inhibits insulin-mediated glycogenesis but enhances glycolysis in human skeletal muscle.	Epinephrine	0-11	insulin	Homo sapiens	21-28
1900669-1	1991	The effect of epinephrine (E) infusion on insulin-mediated glucose metabolism in humans has been studied.	Epinephrine	14-25	insulin	Homo sapiens	42-49
1846614-6	1991	This action appears to be less important for activation of PLA2 by epinephrine.	Epinephrine	67-78	phospholipase A2 group IB	Canis lupus familiaris	59-63
1864314-3	1991	Simultaneously with the change in blood pressure and heart rate, the concentrations of plasma epinephrine and norepinephrine rose 4 and 10 min after VIP administration.	Epinephrine	94-105	vasoactive intestinal peptide	Rattus norvegicus	149-152
1675919-3	1991	Bombesin-induced (10 ng) elevation of plasma epinephrine but not norepinephrine was prevented by co-administration of somatostatin-28 (100 ng).	Epinephrine	45-56	gastrin releasing peptide	Homo sapiens	0-8
1675919-3	1991	Bombesin-induced (10 ng) elevation of plasma epinephrine but not norepinephrine was prevented by co-administration of somatostatin-28 (100 ng).	Epinephrine	45-56	somatostatin	Homo sapiens	118-133
1705122-0	1991	Endothelin-1 stimulation of noradrenaline and adrenaline release from adrenal chromaffin cells.	Epinephrine	31-41	endothelin 1	Bos taurus	0-12
1705122-1	1991	Endothelin-1 (ET-1) stimulated release of both noradrenaline and adrenaline from cultured bovine adrenal chromaffin cells; stimulated release was small compared to that elicited by 50 mM potassium.	Epinephrine	50-60	endothelin 1	Bos taurus	0-12
1705122-1	1991	Endothelin-1 (ET-1) stimulated release of both noradrenaline and adrenaline from cultured bovine adrenal chromaffin cells; stimulated release was small compared to that elicited by 50 mM potassium.	Epinephrine	50-60	endothelin 1	Bos taurus	14-18
1705122-7	1991	These results show that ET-1 may stimulate both noradrenaline and adrenaline containing chromaffin cells by a mechanism which, while partially dependent on dihydropyridine sensitive calcium channels, is distinct from the calcium channel agonist or membrane depolarization.	Epinephrine	51-61	endothelin 1	Bos taurus	24-28
1671583-1	1991	The enzyme tyrosine hydroxylase catalyzes the first step in the biosynthesis of dopamine, norepinephrine, and epinephrine.	Epinephrine	93-104	tyrosine hydroxylase	Rattus norvegicus	11-31
1709230-4	1991	Furthermore, the selective beta 2-adrenoceptor antagonist ICI 118,551 (10(-7) mol/L), but not the selective beta 1-adrenoceptor antagonist ICI 89,406 (10(-7) mol/L), reduced electrically evoked overflow of (3H)noradrenaline in tissue preincubated with adrenaline but not in tissue preincubated with noradrenaline.	Epinephrine	213-223	beta-2 adrenergic receptor	Cavia porcellus	27-46
2060427-11	1991	The diminished catecholamine responses were primarily due to decreased peak epinephrine responses after intensive insulin therapy compared with insulin withdrawal (P = 0.011).	Epinephrine	76-87	insulin	Homo sapiens	114-121
1847023-10	1991	A subtle increase in plasma concentrations of norepinephrine and epinephrine was observed during the ANF infusions.	Epinephrine	49-60	natriuretic peptide A	Homo sapiens	101-104
1671088-2	1991	When the cells were exposed to beta-adrenergic agonists, they accumulated cyclic AMP in the following order of potency: isoproterenol much greater than norepinephrine greater than epinephrine, which is indicative of a beta 1-subtype receptor.	Epinephrine	155-166	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	218-224
1671406-5	1991	The [Ca++]i concentration of keratinocytes was increased immediately and transiently by epinephrine.	Epinephrine	88-99	carbonic anhydrase 1	Homo sapiens	5-11
1671406-7	1991	The beta-antagonist, propranolol, inhibited the [Ca++]i increase induced by epinephrine and salbutamol (a beta-2-agonist).	Epinephrine	76-87	carbonic anhydrase 1	Homo sapiens	49-55
1671406-7	1991	The beta-antagonist, propranolol, inhibited the [Ca++]i increase induced by epinephrine and salbutamol (a beta-2-agonist).	Epinephrine	76-87	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	106-112
1825160-6	1991	Our results demonstrate that epinephrine infusion stimulates fetal ANF secretion and to a lesser extent AVP secretion and significantly influences fetal renal function.	Epinephrine	29-40	natriuretic peptides A	Ovis aries	67-70
1825160-6	1991	Our results demonstrate that epinephrine infusion stimulates fetal ANF secretion and to a lesser extent AVP secretion and significantly influences fetal renal function.	Epinephrine	29-40	vasopressin-neurophysin 2-copeptin	Ovis aries	104-107
1671330-3	1991	Under the same conditions, adrenaline raised intracellular pH (pHi) by about 0.1 unit.	Epinephrine	27-37	glucose-6-phosphate isomerase	Rattus norvegicus	59-61
1671330-3	1991	Under the same conditions, adrenaline raised intracellular pH (pHi) by about 0.1 unit.	Epinephrine	27-37	glucose-6-phosphate isomerase	Rattus norvegicus	63-66
1671330-4	1991	The increase in pHi induced by adrenaline was prevented by 5 nM-prazosin, but not by 5 nM-yohimbine, again suggesting involvement of the alpha 1-adrenoceptor.	Epinephrine	31-41	glucose-6-phosphate isomerase	Rattus norvegicus	16-19
1671330-7	1991	273, 339-346], the increase in pHi induced by adrenaline may be involved in its stimulation of protein synthesis.	Epinephrine	46-56	glucose-6-phosphate isomerase	Rattus norvegicus	31-34
1671330-9	1991	As discussed, the increase in pHi induced by adrenaline may be responsible for this effect.	Epinephrine	45-55	glucose-6-phosphate isomerase	Rattus norvegicus	30-33
1825160-1	1991	Circulating epinephrine alters atrial natriuretic factor (ANF) and arginine vasopressin (AVP) secretion, and all three hormones influence renal function.	Epinephrine	12-23	natriuretic peptides A	Ovis aries	31-56
1825160-1	1991	Circulating epinephrine alters atrial natriuretic factor (ANF) and arginine vasopressin (AVP) secretion, and all three hormones influence renal function.	Epinephrine	12-23	natriuretic peptides A	Ovis aries	58-61
1825160-1	1991	Circulating epinephrine alters atrial natriuretic factor (ANF) and arginine vasopressin (AVP) secretion, and all three hormones influence renal function.	Epinephrine	12-23	vasopressin-neurophysin 2-copeptin	Ovis aries	89-92
1825160-3	1991	The second epinephrine infusion dose evoked significant increases in urine flow (V; 0.7 +/- 0.2 to 1.2 +/- 0.2 ml/min), free water clearance (CH2O; 0.3 +/- 0.1 to 0.7 +/- 0.1 ml/min), glomerular filtration rate (GFR; 3.9 +/- 0.7 to 5.4 +/- 0.8 ml/min), fractional water excretion (V/CH2O; 19 +/- 3 to 25 +/- 2%), mean arterial pressure (MAP; 45 +/- 3 to 51 +/- 4 mmHg), and a 94% increase in plasma ANF levels.	Epinephrine	11-22	natriuretic peptides A	Ovis aries	399-402
1765054-0	1991	Thermogenic effect of adrenaline: interaction with insulin.	Epinephrine	22-32	insulin	Homo sapiens	51-58
1823245-0	1991	Involvement of PAF-acether and eicosanoids in adrenaline-induced pulmonary edema in mice.	Epinephrine	46-56	patchy fur	Mus musculus	15-18
1846526-7	1991	We conclude that PAF, ADP and adrenaline regulate exposure of fibrinogen binding sites through a common mechanism consisting of two independent pathways, one dominated by PKC and the other by an as yet unidentified cyclic AMP-sensitive step.	Epinephrine	30-40	fibrinogen beta chain	Homo sapiens	62-72
1716452-4	1991	(3) Calculation of the efficacy of insulin to inhibit epinephrine-stimulated glycerol release as a function of temperature yielded a biphasic response, with a distinct optimum around 41 degrees C, in a similar manner to the effects of insulin on hexose transport activation determined previously.	Epinephrine	54-65	insulin	Homo sapiens	35-42
1716452-4	1991	(3) Calculation of the efficacy of insulin to inhibit epinephrine-stimulated glycerol release as a function of temperature yielded a biphasic response, with a distinct optimum around 41 degrees C, in a similar manner to the effects of insulin on hexose transport activation determined previously.	Epinephrine	54-65	insulin	Homo sapiens	235-242
2019081-0	1991	Renal and systemic plasma immunoreactive neuropeptide Y and calcitonin gene-related peptide responses to mental stress and adrenaline in humans.	Epinephrine	123-133	neuropeptide Y	Homo sapiens	41-55
1765054-1	1991	The contribution of insulin (3.6 pmol.kg body mass-1.min-1) to adrenaline-induced (0.164 nmol.kg fat free mass-1.min-1) thermogenesis was studied in ten postabsorptive healthy volunteers using two sequential protocols.	Epinephrine	63-73	insulin	Homo sapiens	20-27
1765054-1	1991	The contribution of insulin (3.6 pmol.kg body mass-1.min-1) to adrenaline-induced (0.164 nmol.kg fat free mass-1.min-1) thermogenesis was studied in ten postabsorptive healthy volunteers using two sequential protocols.	Epinephrine	63-73	adhesion G protein-coupled receptor V1	Homo sapiens	106-112
1725422-3	1991	Intracisternal administration of 0.03 nmol ET-1 gave rise to a significant elevation in plasma noradrenaline and adrenaline levels.	Epinephrine	98-108	endothelin 1	Rattus norvegicus	43-47
2046301-0	1991	[The effect of adrenaline on the succinate dehydrogenase activity in functionally changed (lymphoid leukosis) lymphocytes in mice].	Epinephrine	15-25	aminoadipate-semialdehyde synthase	Mus musculus	33-56
2043222-3	1991	The insulin-antagonistic effects of glucagon and adrenaline are of rapid onset, whereas those of cortisol and growth hormone are only observed after a lag period of several hours.	Epinephrine	49-59	insulin	Homo sapiens	4-11
2043222-7	1991	Adrenaline induces the early posthypoglycaemic insulin resistance, whereas cortisol and growth hormone are important for the insulin resistance that is observed later following hypoglycaemia.	Epinephrine	0-10	insulin	Homo sapiens	47-54
2046301-1	1991	The activity of succinate dehydrogenase (SDH) in lymphocytes of peripheral blood of AKR mice was measured in response to intraperitoneal injection of epinephrine hydrochloride at a dose of 1 mg/kg.	Epinephrine	150-175	aminoadipate-semialdehyde synthase	Mus musculus	16-39
2046301-1	1991	The activity of succinate dehydrogenase (SDH) in lymphocytes of peripheral blood of AKR mice was measured in response to intraperitoneal injection of epinephrine hydrochloride at a dose of 1 mg/kg.	Epinephrine	150-175	aminoadipate-semialdehyde synthase	Mus musculus	41-44
2046301-2	1991	SDH reactions to epinephrine were of two types: increase or decrease of activity.	Epinephrine	17-28	aminoadipate-semialdehyde synthase	Mus musculus	0-3
2046301-4	1991	The decrease of epinephrine activation of SDH in lymphocytes was found to be correlated with the age of animals and hematological manifestations of hemoblastosis they developed.	Epinephrine	16-27	aminoadipate-semialdehyde synthase	Mus musculus	42-45
1714551-1	1991	Focal iontophoretic injections of the retrograde tracer Fluoro-Gold into the locus coeruleus were combined with immunocytochemistry for phenylethanolamine N-methyltransferase, the final enzyme in the synthesis of epinephrine.	Epinephrine	213-224	phenylethanolamine-N-methyltransferase	Rattus norvegicus	136-174
1650417-2	1991	Recently, it was reported that porcine NPY was an inhibitor of in vitro human platelet aggregation induced by epinephrine, an observation which would have important implications regarding platelet-vascular interactions during states involving platelet activation and thrombosis.	Epinephrine	110-121	neuropeptide Y	Homo sapiens	39-42
1654493-3	1991	Ang II, 0.5 microgram, in the lateral cerebral ventricle (ICV) markedly and significantly (p less than 0.05) increased the epinephrine dose, at the occurrence of ventricular premature beats compared to the control group 228 +/- 11 (SEM) vs 116 +/- 7 micrograms epinephrine/kg and at the onset of fatal arrhythmias 225 +/- 13 vs 185 +/- 9 micrograms epinephrine/kg.	Epinephrine	123-134	angiotensinogen	Rattus norvegicus	0-6
1654493-3	1991	Ang II, 0.5 microgram, in the lateral cerebral ventricle (ICV) markedly and significantly (p less than 0.05) increased the epinephrine dose, at the occurrence of ventricular premature beats compared to the control group 228 +/- 11 (SEM) vs 116 +/- 7 micrograms epinephrine/kg and at the onset of fatal arrhythmias 225 +/- 13 vs 185 +/- 9 micrograms epinephrine/kg.	Epinephrine	261-272	angiotensinogen	Rattus norvegicus	0-6
1654493-3	1991	Ang II, 0.5 microgram, in the lateral cerebral ventricle (ICV) markedly and significantly (p less than 0.05) increased the epinephrine dose, at the occurrence of ventricular premature beats compared to the control group 228 +/- 11 (SEM) vs 116 +/- 7 micrograms epinephrine/kg and at the onset of fatal arrhythmias 225 +/- 13 vs 185 +/- 9 micrograms epinephrine/kg.	Epinephrine	261-272	angiotensinogen	Rattus norvegicus	0-6
1646739-3	1991	CT-activated Ca2+ inflow was completely blocked by the presence of the Ca2(+)-antagonist verapamil at a concentration of 10(-8) M. Meanwhile, epinephrine (10(-8) to 10(-4) M) or phenylephrine (10(-8) to 10(-4) M) increased Ca2+ inflow within 60 s after the addition of 45Ca2+ to the cells.	Epinephrine	142-153	calcitonin-related polypeptide alpha	Rattus norvegicus	0-2
1861777-2	1991	Treatment with FLA63, an inhibitor of dopamine beta-hydroxylase (10 mg/kg, 2 h before killing), induced depletion of noradrenaline and adrenaline in the preoptic area and median eminence (sites, respectively, inside and outside the blood-brain barrier) but, paradoxically, resulted in a significant increase (+77%) in the pineal content of adrenaline without affecting that of noradrenaline.	Epinephrine	120-130	dopamine beta-hydroxylase	Rattus norvegicus	38-63
1861777-2	1991	Treatment with FLA63, an inhibitor of dopamine beta-hydroxylase (10 mg/kg, 2 h before killing), induced depletion of noradrenaline and adrenaline in the preoptic area and median eminence (sites, respectively, inside and outside the blood-brain barrier) but, paradoxically, resulted in a significant increase (+77%) in the pineal content of adrenaline without affecting that of noradrenaline.	Epinephrine	135-145	dopamine beta-hydroxylase	Rattus norvegicus	38-63
1686497-7	1991	A concentration-dependent stimulatory response (EC50 200 nM) was obtained with salbutamol (beta 2-adrenoceptor agonist) and stimulation by adrenaline or salbutamol could be blocked by a selective beta 2-adrenoceptor antagonist (ICI 118,551).	Epinephrine	139-149	adrenoceptor beta 2	Bos taurus	91-110
1861777-3	1991	Treatment with LY134046, an inhibitor of phenylethanolamine N-methyltransferase (40 mg/kg, 5 and 2 h before killing), induced depletion of adrenaline in the preoptic area and median eminence but, again, resulted in a paradoxical and large increase in pineal adrenaline (+224%); this increase was prevented by prior adrenalectomy.	Epinephrine	139-149	phenylethanolamine-N-methyltransferase	Rattus norvegicus	41-79
1861777-3	1991	Treatment with LY134046, an inhibitor of phenylethanolamine N-methyltransferase (40 mg/kg, 5 and 2 h before killing), induced depletion of adrenaline in the preoptic area and median eminence but, again, resulted in a paradoxical and large increase in pineal adrenaline (+224%); this increase was prevented by prior adrenalectomy.	Epinephrine	258-268	phenylethanolamine-N-methyltransferase	Rattus norvegicus	41-79
2046887-5	1991	Vasopressin also caused decrease of Epinephrine (E) from both the innervated (68-73%) and denervated (69-74%) glands 0.5 and 4 h after injection indicating that the splanchnic nerve has no effect on vasopressin-induced release of E. Accelerated resynthesis of NE exceeding the control value (44-94%) was encountered 144 and 216 h after injection as compared to a slower increase (14%) in denervated glands 216 h after injection.	Epinephrine	36-47	arginine vasopressin	Homo sapiens	0-11
1686497-7	1991	A concentration-dependent stimulatory response (EC50 200 nM) was obtained with salbutamol (beta 2-adrenoceptor agonist) and stimulation by adrenaline or salbutamol could be blocked by a selective beta 2-adrenoceptor antagonist (ICI 118,551).	Epinephrine	139-149	adrenoceptor beta 2	Bos taurus	196-215
2281852-5	1990	The subsequent hypokalemia seems to be caused by the beta 2-mimetic component of epinephrine effecting the uptake of this ion into striated muscle cells.	Epinephrine	81-92	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	53-59
2254565-1	1990	Phenylethanolamine N-methyltransferase (PNMT) is the rate-limiting enzyme in the synthesis of epinephrine and a specific marker for adrenergic neurons.	Epinephrine	94-105	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
2176947-11	1990	The plasma adrenaline concentration rose significantly (P less than 0.01), but only transiently, during dopamine infusion at a rate of 2 micrograms min-1 kg-1.	Epinephrine	11-21	CD59 molecule (CD59 blood group)	Homo sapiens	148-158
2254565-1	1990	Phenylethanolamine N-methyltransferase (PNMT) is the rate-limiting enzyme in the synthesis of epinephrine and a specific marker for adrenergic neurons.	Epinephrine	94-105	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
2254565-4	1990	In early Alzheimer"s disease there is a decrease in PNMT in axon terminals and in total PNMT in epinephrine cell bodies and terminals compared with control values.	Epinephrine	96-107	phenylethanolamine N-methyltransferase	Homo sapiens	88-92
2254565-6	1990	In contrast, in advanced Alzheimer"s disease, PNMT activity increases by 124% in epinephrine neuronal cell bodies compared with controls.	Epinephrine	81-92	phenylethanolamine N-methyltransferase	Homo sapiens	46-50
2254565-11	1990	We further postulate that epinephrine, the product of PNMT, and its further metabolites are endogenous neurotoxins.	Epinephrine	26-37	phenylethanolamine N-methyltransferase	Homo sapiens	54-58
2254565-12	1990	Therefore, the accumulation of PNMT in epinephrine cell bodies may contribute to the degeneration of these neurons in Alzheimer"s disease.	Epinephrine	39-50	phenylethanolamine N-methyltransferase	Homo sapiens	31-35
1979763-3	1990	Both insulin preparations gave close to identical responses for glucose, glucagon, growth hormone, adrenaline, and somatostatin.	Epinephrine	99-109	insulin	Homo sapiens	5-12
1701016-4	1990	Treatment of WB cells with hormones linked to Ca2+ mobilization and protein kinase C (PKC) activation, including angiotensin II, [Arg8]vasopressin, or epinephrine, stimulated rapid (less than or equal to 15-s) and transient increases in the P-Tyr content of several proteins (p120/125, p75/78, and p66).	Epinephrine	151-162	bromodomain containing 8	Rattus norvegicus	276-284
1980236-2	1990	The alpha receptor is divided into two types, alpha 1 and alpha 2, based on response to epinephrine and norepinephrine.	Epinephrine	88-99	adrenoceptor alpha 1D	Homo sapiens	46-65
2172775-8	1990	Additionally, 100 microM 5"-guanylylimidodiphosphate, produced a rightward shift in the epinephrine competition curve, with resultant increases in both the Ki value and Hill coefficient, suggestive of a functional interaction of the cloned receptor with native guanine nucleotide-binding protein(s) of Ltk- membranes.	Epinephrine	88-99	leukocyte receptor tyrosine kinase	Homo sapiens	302-305
2171909-15	1990	Thus, the secretion of ACTH stimulated by the action of IL-1 beta at the ME depends, in part, on the local secretion of norepinephrine and epinephrine interacting with both alpha and beta adrenergic receptors.	Epinephrine	123-134	interleukin 1 beta	Rattus norvegicus	56-65
2243344-6	1990	In the isolated perfused rat adrenal gland, DuP 753 at 10(-6) and 10(-4) M but not PD123177 at 10(-3) M blocked the AII-induced epinephrine secretion.	Epinephrine	128-139	angiotensinogen	Rattus norvegicus	116-119
2226440-1	1990	Catecholamines (adrenaline, noradrenaline and dopamine) are potent inhibitors of phenylalanine 4-monooxygenase (phenylalanine hydroxylase, EC 1.14.16.1).	Epinephrine	16-26	phenylalanine hydroxylase	Rattus norvegicus	112-137
1717041-3	1990	In this area, nearly all adrenaline neurons were GLU-LIR.	Epinephrine	25-35	CD300c molecule	Homo sapiens	53-56
1717041-5	1990	Many adrenaline neurons, especially of the C1 group, contained substance P-LI in addition to GLU-like immunoreactivity (LI).	Epinephrine	5-15	tachykinin precursor 1	Homo sapiens	63-74
2211717-6	1990	Also consistent with lysosome enzyme studies, there was little surface expression of LAMP-1 in response to the weak agonists ADP and epinephrine.	Epinephrine	133-144	lysosomal associated membrane protein 1	Homo sapiens	85-91
2169395-9	1990	Thus, the secretion of both hypothalamic epinephrine and, to some extent, norepinephrine is involved in the ACTH response to the activation of catecholaminergic neurons in the IV.	Epinephrine	41-52	proopiomelanocortin	Homo sapiens	108-112
2169395-5	1990	Selective inhibitors of epinephrine synthesis, SKF 64139 and 2,3-dichloro-alpha-methylbenzylamine (DCMB), significantly reduced (P less than 0.01) the ACTH response to 0.05 mg/kg body wt nicotine iv, without affecting median eminence CRF content.	Epinephrine	24-35	proopiomelanocortin	Homo sapiens	151-155
2172902-7	1990	Before ritodrine administration, epinephrine significantly increased plasma FFA, lactate, glucose, and glucagon concentrations and decreased insulin.	Epinephrine	33-44	LOC105613195	Ovis aries	141-148
2172902-9	1990	Decreases in insulin during epinephrine administration were unchanged by ritodrine.	Epinephrine	28-39	LOC105613195	Ovis aries	13-20
2253318-2	1990	PAF infusion (50 ng/kg/min for 60 min) resulted in a sustained hypotension, with tachycardia and elevated plasma norepinephrine (NE; 1.8-fold increase), epinephrine (E; 6.7-fold increase), and dopamine (DA; 1.0-fold increase) at 30 min after beginning infusion.	Epinephrine	116-127	PCNA clamp associated factor	Rattus norvegicus	0-3
2255331-1	1990	Recent results have indicated that the 5-HT1A receptor subtype mediates the adrenaline-releasing and hyperglycemic effects of 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.	Epinephrine	76-86	5-hydroxytryptamine receptor 1A	Rattus norvegicus	39-45
2255331-10	1990	The data suggest that central 5-HT1A receptors, but neither 5-HT1B nor 5-HT1D receptors, regulate plasma adrenaline and glucose levels.	Epinephrine	105-115	5-hydroxytryptamine receptor 1A	Rattus norvegicus	30-36
1978793-2	1990	In this work, we have studied the effect of several concentrations of prolactin on the synthesis, storage and release of norepinephrine and epinephrine using cultured bovine adrenal chromaffin cells.	Epinephrine	124-135	prolactin	Bos taurus	70-79
2171289-1	1990	Adrenaline-induced changes in heart rate, blood pressure, plasma adrenaline and noradrenaline, cortisol, glucagon, insulin, cAMP, glucose lactate, glycerol and beta-hydroxybutyrate were studied preoperatively and 4 and 24 h after skin incision in 8 patients undergoing elective cholecystectomy.	Epinephrine	0-10	insulin	Homo sapiens	115-122
2178206-5	1990	There was an inverse correlation between plasma epinephrine concentration and beta 2-adrenergic receptor density (r = -0.959, p = 0.01).	Epinephrine	48-59	adrenoceptor beta 2	Homo sapiens	78-104
2176295-7	1990	The epinephrine infusions resulted in physiological increases in plasma glucose and insulin, but did not inhibit food consumption.	Epinephrine	4-15	insulin	Canis lupus familiaris	84-91
2176295-10	1990	These data show that epinephrine infusions which produce physiological changes in plasma glucose and insulin do not alter feeding behavior of mongrel dogs.	Epinephrine	21-32	insulin	Canis lupus familiaris	101-108
1975987-7	1990	We conclude that basal insulin concentrations mask some of the thermogenic effects of thyroid hormones and epinephrine.	Epinephrine	107-118	insulin	Homo sapiens	23-30
1975987-8	1990	Thus insulin antagonism may suppress some of the thermogenic actions of thyroid hormones and epinephrine.	Epinephrine	93-104	insulin	Homo sapiens	5-12
2243613-6	1990	Insulin brought about augmented synthesis of epinephrine (E) surpassing the control value in the innervated glands 72 h after treatment.	Epinephrine	45-56	insulin	Homo sapiens	0-7
2172886-2	1990	As a parameter for the change of the Adenylcyclase activity we determined the Adenylcyclase stimulatability caused by the neurotransmitters noradrenaline, dopamine and adrenaline.	Epinephrine	143-153	adenylate cyclase 1	Homo sapiens	37-50
2103314-3	1990	Adrenaline infusions in man produce increases in both factor VIII and fibrinolysis and the rise in factor VIII is blocked by pretreatment with propranolol.	Epinephrine	0-10	cytochrome c oxidase subunit 8A	Homo sapiens	61-65
2103314-3	1990	Adrenaline infusions in man produce increases in both factor VIII and fibrinolysis and the rise in factor VIII is blocked by pretreatment with propranolol.	Epinephrine	0-10	cytochrome c oxidase subunit 8A	Homo sapiens	106-110
2103314-4	1990	Receptor blockade with propranolol also prevents the rise in factor VIII associated with hypoglycaemia to support the view that adrenaline is an important mediator under these circumstances.	Epinephrine	128-138	cytochrome c oxidase subunit 8A	Homo sapiens	68-72
2172886-2	1990	As a parameter for the change of the Adenylcyclase activity we determined the Adenylcyclase stimulatability caused by the neurotransmitters noradrenaline, dopamine and adrenaline.	Epinephrine	143-153	adenylate cyclase 1	Homo sapiens	78-91
2119530-3	1990	Low and high dose adrenaline infusions yielding plasma adrenaline levels of 0.9 +/- 0.1 and 3.4 +/- 0.4 nmol/l, respectively, dose-dependently increased t-PA levels with a concomitant decrease in PAI-1 levels.	Epinephrine	18-28	plasminogen activator, tissue type	Homo sapiens	153-157
2164526-6	1990	We conclude that acute vigorous increases in endogenous epinephrine evoked by insulin-induced hypoglycemia are associated with increases in lymphocyte beta 2-adrenoceptor function, redistribution of lymphocyte subsets, and an (at least transiently) attenuated in vitro immune responsiveness.	Epinephrine	56-67	insulin	Homo sapiens	78-85
2164526-6	1990	We conclude that acute vigorous increases in endogenous epinephrine evoked by insulin-induced hypoglycemia are associated with increases in lymphocyte beta 2-adrenoceptor function, redistribution of lymphocyte subsets, and an (at least transiently) attenuated in vitro immune responsiveness.	Epinephrine	56-67	adrenoceptor beta 2	Homo sapiens	151-170
2172354-12	1990	Since the PNMT-IR projections are directed towards the intermediolateral cell column, it seems likely that all three groups of medullary adrenaline-containing neurons contribute to the regulation of sympathetic outflow.	Epinephrine	137-147	phenylethanolamine-N-methyltransferase	Rattus norvegicus	10-14
2119530-3	1990	Low and high dose adrenaline infusions yielding plasma adrenaline levels of 0.9 +/- 0.1 and 3.4 +/- 0.4 nmol/l, respectively, dose-dependently increased t-PA levels with a concomitant decrease in PAI-1 levels.	Epinephrine	18-28	serpin family E member 1	Homo sapiens	196-201
2119530-3	1990	Low and high dose adrenaline infusions yielding plasma adrenaline levels of 0.9 +/- 0.1 and 3.4 +/- 0.4 nmol/l, respectively, dose-dependently increased t-PA levels with a concomitant decrease in PAI-1 levels.	Epinephrine	55-65	plasminogen activator, tissue type	Homo sapiens	153-157
2119530-3	1990	Low and high dose adrenaline infusions yielding plasma adrenaline levels of 0.9 +/- 0.1 and 3.4 +/- 0.4 nmol/l, respectively, dose-dependently increased t-PA levels with a concomitant decrease in PAI-1 levels.	Epinephrine	55-65	serpin family E member 1	Homo sapiens	196-201
2115784-1	1990	Platelet aggregation induced by threshold concentrations of agonists such as collagen, PAF or epinephrine was inhibited in vitro by 100 microM aspirin but was restored by stimulating platelets with high concentrations of collagen, PAF or by a combination of epinephrine and PAF.	Epinephrine	94-105	PCNA clamp associated factor	Homo sapiens	231-234
2115784-1	1990	Platelet aggregation induced by threshold concentrations of agonists such as collagen, PAF or epinephrine was inhibited in vitro by 100 microM aspirin but was restored by stimulating platelets with high concentrations of collagen, PAF or by a combination of epinephrine and PAF.	Epinephrine	94-105	PCNA clamp associated factor	Homo sapiens	231-234
2095748-6	1990	Findings in both groups of patients mimicked the results of parenteral epinephrine administration: a pan-B and -T lymphocytosis with marked increase in CD56 (fourfold to fivefold) and CD8 cells (threefold to fourfold) as well as moderate increases in CD20 and CD4 cells (twofold), resulting in a decrease in the CD4/CD8 ratio compared with control values.	Epinephrine	71-82	neural cell adhesion molecule 1	Homo sapiens	152-156
2095748-6	1990	Findings in both groups of patients mimicked the results of parenteral epinephrine administration: a pan-B and -T lymphocytosis with marked increase in CD56 (fourfold to fivefold) and CD8 cells (threefold to fourfold) as well as moderate increases in CD20 and CD4 cells (twofold), resulting in a decrease in the CD4/CD8 ratio compared with control values.	Epinephrine	71-82	CD8a molecule	Homo sapiens	184-187
2115784-1	1990	Platelet aggregation induced by threshold concentrations of agonists such as collagen, PAF or epinephrine was inhibited in vitro by 100 microM aspirin but was restored by stimulating platelets with high concentrations of collagen, PAF or by a combination of epinephrine and PAF.	Epinephrine	258-269	PCNA clamp associated factor	Homo sapiens	87-90
2095748-6	1990	Findings in both groups of patients mimicked the results of parenteral epinephrine administration: a pan-B and -T lymphocytosis with marked increase in CD56 (fourfold to fivefold) and CD8 cells (threefold to fourfold) as well as moderate increases in CD20 and CD4 cells (twofold), resulting in a decrease in the CD4/CD8 ratio compared with control values.	Epinephrine	71-82	keratin 20	Homo sapiens	251-255
2095748-6	1990	Findings in both groups of patients mimicked the results of parenteral epinephrine administration: a pan-B and -T lymphocytosis with marked increase in CD56 (fourfold to fivefold) and CD8 cells (threefold to fourfold) as well as moderate increases in CD20 and CD4 cells (twofold), resulting in a decrease in the CD4/CD8 ratio compared with control values.	Epinephrine	71-82	CD4 molecule	Homo sapiens	260-263
2115784-1	1990	Platelet aggregation induced by threshold concentrations of agonists such as collagen, PAF or epinephrine was inhibited in vitro by 100 microM aspirin but was restored by stimulating platelets with high concentrations of collagen, PAF or by a combination of epinephrine and PAF.	Epinephrine	258-269	PCNA clamp associated factor	Homo sapiens	231-234
2095748-6	1990	Findings in both groups of patients mimicked the results of parenteral epinephrine administration: a pan-B and -T lymphocytosis with marked increase in CD56 (fourfold to fivefold) and CD8 cells (threefold to fourfold) as well as moderate increases in CD20 and CD4 cells (twofold), resulting in a decrease in the CD4/CD8 ratio compared with control values.	Epinephrine	71-82	CD4 molecule	Homo sapiens	312-315
2115784-1	1990	Platelet aggregation induced by threshold concentrations of agonists such as collagen, PAF or epinephrine was inhibited in vitro by 100 microM aspirin but was restored by stimulating platelets with high concentrations of collagen, PAF or by a combination of epinephrine and PAF.	Epinephrine	258-269	PCNA clamp associated factor	Homo sapiens	231-234
2095748-6	1990	Findings in both groups of patients mimicked the results of parenteral epinephrine administration: a pan-B and -T lymphocytosis with marked increase in CD56 (fourfold to fivefold) and CD8 cells (threefold to fourfold) as well as moderate increases in CD20 and CD4 cells (twofold), resulting in a decrease in the CD4/CD8 ratio compared with control values.	Epinephrine	71-82	CD8a molecule	Homo sapiens	316-319
2142038-0	1990	Desensitization of the platelet aggregation response to adrenaline during insulin-induced hypoglycaemia in man.	Epinephrine	56-66	insulin	Homo sapiens	74-81
1971535-2	1990	(-)Norepinephrine produced stimulation predominantly through beta 1-receptors and (-)epinephrine through both beta 1- and beta 2-receptors.	Epinephrine	6-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	61-67
1971535-2	1990	(-)Norepinephrine produced stimulation predominantly through beta 1-receptors and (-)epinephrine through both beta 1- and beta 2-receptors.	Epinephrine	6-17	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	110-116
1971535-2	1990	(-)Norepinephrine produced stimulation predominantly through beta 1-receptors and (-)epinephrine through both beta 1- and beta 2-receptors.	Epinephrine	6-17	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	122-128
1971535-4	1990	There was an enhanced responsiveness to (-)epinephrine (atenolol treated: -log M EC50, 7.57 +/- 0.07; non-beta-blocker treated: -log M EC50, 6.77 +/- 0.17; p less than 0.001), and the relative importance of beta 2-adrenoceptor stimulation was increased for both (-)norepinephrine and (-)epinephrine.	Epinephrine	40-54	adrenoceptor beta 2	Homo sapiens	207-226
2142038-1	1990	The aim of the present study was to investigate the influence of insulin-induced hypoglycaemia on platelet sensitivity to adrenaline and non-adrenergic agonists in man.	Epinephrine	122-132	insulin	Homo sapiens	65-72
2142038-9	1990	Thus, insulin-induced hypoglycaemia increases platelet sensitivity to non-adrenergic agonists and decreases platelet response to adrenaline.	Epinephrine	129-139	insulin	Homo sapiens	6-13
1974548-8	1990	Propranolol blocked the inhibitory effect of epinephrine on insulin binding.	Epinephrine	45-56	insulin	Sus scrofa	60-67
1974548-6	1990	In the presence of theophylline, epinephrine decreased binding at both low and high insulin concentrations; however, ractopamine plus theophylline decreased binding only at the low insulin concentration.	Epinephrine	33-44	insulin	Sus scrofa	84-91
2172554-3	1990	ODC activity peaked 4 h after the addition of serum and returned to initial levels at 8 h. In the absence of serum, non-cytotoxic concentrations of the adrenergic agonists epinephrine, norepinephrine or isoproterenol did not stimulate ODC activity.	Epinephrine	172-183	ornithine decarboxylase 1	Rattus norvegicus	0-3
2164246-1	1990	Several animal studies have demonstrated an improvement in cerebral blood flow (CBF) and myocardial blood flow (MBF) after the administration of epinephrine (E) 0.20 mg/kg during closed chest CPR.	Epinephrine	145-156	cytochrome p450 oxidoreductase	Sus scrofa	192-195
2359527-6	1990	The results suggest that adrenaline secretion in response to hypoglycaemic stress in anaesthetized rats is potentiated by hypovolaemic activation of the renin-angiotensin system.	Epinephrine	25-35	renin	Rattus norvegicus	153-158
1971540-4	1990	Plasma epinephrine increased with all three treatments and more with beta 1-blockade than with placebo.	Epinephrine	7-18	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	69-75
2354362-7	1990	These results suggest that phenylethanolamine N-methyltransferase (PNMT)-containing terminals in the rat spinal cord can synthesize epinephrine, but that little if any epinephrine is stored in synaptic vesicles due to the rapid metabolism of cytoplasmic catecholamines by monoamine oxidase.	Epinephrine	132-143	phenylethanolamine-N-methyltransferase	Rattus norvegicus	27-65
2354362-7	1990	These results suggest that phenylethanolamine N-methyltransferase (PNMT)-containing terminals in the rat spinal cord can synthesize epinephrine, but that little if any epinephrine is stored in synaptic vesicles due to the rapid metabolism of cytoplasmic catecholamines by monoamine oxidase.	Epinephrine	132-143	phenylethanolamine-N-methyltransferase	Rattus norvegicus	67-71
2108594-0	1990	Effect of epinephrine on end-tidal carbon dioxide monitoring during CPR.	Epinephrine	10-21	cytochrome p450 oxidoreductase	Canis lupus familiaris	68-71
1970555-4	1990	In the presence of adenosine deaminase or theophylline, all three beta-adrenergic agonists inhibited basal lipogenesis, but only epinephrine and ractopamine inhibited insulin-stimulated lipogenesis.	Epinephrine	129-140	insulin	Sus scrofa	167-174
2178376-6	1990	Although diuretic use is the most frequent cause of hypokalemia, epinephrine can also lower serum potassium as a result of stimulation of the beta 2 adrenoreceptor.	Epinephrine	65-76	adrenoceptor beta 2	Homo sapiens	142-163
1968697-8	1990	In situations of stress, however, when large amounts of adrenaline are released from the adrenal medulla, stimulation of cardiac beta-2 adrenoceptors could contribute to additional increases in contractility, heart rate, or both.	Epinephrine	56-66	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	129-135
2137716-10	1990	Because epinephrine increases fibrinogen binding to thrombin-stimulated platelets to a greater extent than ADP, but does not stabilize the aggregates, it is unlikely that the additional fibrinogen binding sites induced by ADP have a major role in inhibiting deaggregation by the combination of inhibitors.	Epinephrine	8-19	coagulation factor II, thrombin	Homo sapiens	52-60
2346532-8	1990	The lack of increase in noradrenaline and adrenaline in the group of patients may be related to reduced activity of dopamine-beta-hydroxylase in patients with congestive heart failure NYHA class IV.	Epinephrine	27-37	dopamine beta-hydroxylase	Homo sapiens	116-141
2190817-4	1990	However, when added after the thrombin-induced response, epinephrine could evoke a considerable release of Ca2+ from cellular stores.	Epinephrine	57-68	coagulation factor II, thrombin	Homo sapiens	30-38
2190817-4	1990	However, when added after the thrombin-induced response, epinephrine could evoke a considerable release of Ca2+ from cellular stores.	Epinephrine	57-68	carbonic anhydrase 2	Homo sapiens	107-110
2190817-5	1990	This appeared to be due to epinephrine recoupling thrombin receptors to phospholipase C. In support of this, epinephrine was able to induce the formation of inositol triphosphate when added after the response to thrombin had also become desensitized.	Epinephrine	27-38	coagulation factor II, thrombin	Homo sapiens	50-58
2190817-5	1990	This appeared to be due to epinephrine recoupling thrombin receptors to phospholipase C. In support of this, epinephrine was able to induce the formation of inositol triphosphate when added after the response to thrombin had also become desensitized.	Epinephrine	109-120	coagulation factor II, thrombin	Homo sapiens	50-58
2190817-5	1990	This appeared to be due to epinephrine recoupling thrombin receptors to phospholipase C. In support of this, epinephrine was able to induce the formation of inositol triphosphate when added after the response to thrombin had also become desensitized.	Epinephrine	109-120	coagulation factor II, thrombin	Homo sapiens	212-220
2227123-6	1990	Moreover, although intravenous injection of CGRP (5.67 nmol/kg) elicited a significant increase in plasma epinephrine and norepinephrine concentrations, concomitant administration of epinephrine and norepinephrine, inducing a more prominent rise in plasma catecholamines than those induced by CGRP, affected neither plasma glucose nor insulin levels.	Epinephrine	106-117	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
2154750-1	1990	The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine.	Epinephrine	224-235	adrenoceptor alpha 1D	Homo sapiens	41-77
2174219-13	1990	In addition, some of the NPY-axons in the ventral portions of striatum and cerebral cortex may be catecholaminergic, and thus originate in brainstem areas recognized to contain NPY and epinephrine or norepinephrine.	Epinephrine	185-196	neuropeptide Y	Homo sapiens	25-28
2275726-2	1990	It has been observed that subcutaneous administration of noradrenaline, dihydroergotoxine, isoprenaline, propranolol and adrenaline influence the amplitudes of ERG and VEP waves.	Epinephrine	60-70	transcriptional regulator ERG	Oryctolagus cuniculus	160-163
2302560-1	1990	We examined whether plasma epinephrine contributes to the increase in regional cerebral blood flow (rCBF) evoked by electrical stimulation of the dorsal medullary reticular formation (DMRF).	Epinephrine	27-38	CCAAT/enhancer binding protein zeta	Rattus norvegicus	100-104
2302560-7	1990	DMRF stimulation induced widespread increases in rCBF associated with a 50-fold increase in plasma epinephrine and a 20-fold increase in norepinephrine without changes in the electroencephalogram.	Epinephrine	99-110	CCAAT/enhancer binding protein zeta	Rattus norvegicus	49-53
2302560-11	1990	However, when infused in conjunction with stimulation of the DMRF, but not medial longitudinal fasciculus, epinephrine fully restored the stimulus-related increases in rCBF in all brain regions to levels comparable to those observed in intact rats.	Epinephrine	107-118	CCAAT/enhancer binding protein zeta	Rattus norvegicus	168-172
2302560-12	1990	We conclude that stimulation of the DMRF elevates rCBF through two mechanisms; by a neurally-mediated increase in local metabolism and thereby flow (adrenal independent secondary vasodilation) and by releasing epinephrine from adrenal medulla which secondarily acts to increase rCBF by an action on brain.	Epinephrine	210-221	CCAAT/enhancer binding protein zeta	Rattus norvegicus	50-54
2302935-0	1990	Effects of prolonged adrenaline infusion and of mental stress on plasma minerals and parathyroid hormone.	Epinephrine	21-31	parathyroid hormone	Homo sapiens	85-104
2269460-1	1990	Fluorimetric methods were used to determine adrenaline, dopamine, noradrenaline, serotonin and tryptamine in the pia mater of the brain and spinal cord of various vertebrates (fishes, birds, mammals) and of man.	Epinephrine	44-54	RPTOR independent companion of MTOR complex 2	Homo sapiens	113-116
2182573-6	1990	Both norepinephrine and epinephrine containing cells of the adrenal medulla exhibited a strong reaction for PLI.	Epinephrine	8-19	serpin family F member 2	Homo sapiens	108-111
11527117-3	1990	Both beta1- and beta2-adrenoceptors couple to adenylate cyclase and mediate positive inotropic effects of isoproterenol and epinephrine on isolated, electrically driven cardiac preparations.	Epinephrine	124-135	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	5-21
11527117-7	1990	However, in situations of stress, when large amounts of epinephrine (acting at both beta1- and beta2-adrenoceptors with the same affinity) are released from the adrenal medulla, activation of cardiac beta2-adrenoceptors may contribute to an additional increase in heart rate and/or contractility.	Epinephrine	56-67	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	84-100
2385755-1	1990	When an adenosine analogue, N6-(amido-3-propyl) adenosine hydrochloride (Agr 529) is administered systemically, it causes a substantial release of epinephrine (E) by the adrenal medulla with no change in plasma norepinephrine (NE) levels.	Epinephrine	147-158	agrin	Rattus norvegicus	73-76
2385755-10	1990	These glucocorticoids stimulate phenylethanolamine-N-methyltransferase, which transforms norepinephrine to epinephrine.	Epinephrine	92-103	phenylethanolamine-N-methyltransferase	Rattus norvegicus	32-70
1970711-7	1990	With combined epinephrine-insulin infusion, the decrease in plasma AA was additive.	Epinephrine	14-25	insulin	Homo sapiens	26-33
2118388-2	1990	It was found that haptoglobin inhibits the PGH synthetase-catalyzed enzymatic reaction, the inhibiting effect being non-competitive with respect to the electron donor, adrenaline.	Epinephrine	168-178	haptoglobin	Homo sapiens	18-29
2331903-1	1990	Epinephrine has been shown to lower the plasma concentrations of several minerals and elevate those of parathyroid hormone (PTH).	Epinephrine	0-11	parathyroid hormone	Homo sapiens	103-122
2113409-4	1990	administration of TRH (0.6 and 3 nmol) at the T8-10 vertebral level resulted in a dose-related increase in epinephrine (E), norepinephrine (NE), and glucose levels, which was suppressed by prior administration of the ganglionic blocker, hexamethonium (1.5 mg/100 g b.	Epinephrine	107-118	thyrotropin releasing hormone	Rattus norvegicus	18-21
2159285-4	1990	In the presence of ethanol, thrombin and other agonists (platelet-activating factor, adrenaline and ADP, as well as fetal-calf serum) stimulated the appearance of phosphatidylethanol, an indicator of phospholipase D activity.	Epinephrine	85-95	coagulation factor II, thrombin	Homo sapiens	28-36
2185644-0	1990	Somatotropin in lactating cows: effect on response to epinephrine and insulin.	Epinephrine	54-65	somatotropin	Bos taurus	0-12
2157007-7	1990	The inhibition potency of S-8 and R-8 against epinephrine-induced aggregatory responses were greatly different, and only R-8 and 4 were alpha 2-agonists on human platelet function.	Epinephrine	46-57	ribosomal protein S8	Homo sapiens	26-37
1970788-1	1990	Bovine adrenal tyrosine hydroxylase (TH) is isolated in a partially inhibited state with the feed-back inhibitors adrenaline and noradrenaline tightly coordinated to high-spin (S = 5/2) Fe(III) at the active site.	Epinephrine	114-124	tyrosine hydroxylase	Bos taurus	15-35
2347421-5	1990	Mammary gland lipase activity was decreased by treatment with epinephrine which increased the fat mobilization in other adipose tissues.	Epinephrine	62-73	lipase, endothelial	Mus musculus	14-20
2155219-9	1990	The calmodulin inhibitors trifluoperazine and W7 (10(-4) M) prevented the stimulation of the exchanger induced by carbachol or epinephrine, but W7 could not block the stimulation produced by A23187 arguing against the involvement of calmodulin in this effect.	Epinephrine	127-138	calmodulin 1	Rattus norvegicus	4-14
1968697-2	1990	In vitro on both isolated electrically driven right and left atrial and left papillary muscle preparations, isoprenaline and adrenaline caused positive inotropic effects via beta-1 and beta-2 adrenoceptor stimulation.	Epinephrine	125-135	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	174-180
1968697-2	1990	In vitro on both isolated electrically driven right and left atrial and left papillary muscle preparations, isoprenaline and adrenaline caused positive inotropic effects via beta-1 and beta-2 adrenoceptor stimulation.	Epinephrine	125-135	adrenoceptor beta 2	Homo sapiens	185-204
1969726-3	1990	However, when AT II was reinfused, it resulted in only 2.1, 2.2, 2.3, 1.9 and 2.4-fold increases, respectively, after infusion of methoxamine, norepinephrine, metaraminol, epinephrine, and phenylephrine.	Epinephrine	146-157	angiotensinogen	Rattus norvegicus	14-19
2155479-1	1990	The effect of epinephrine on the plasma gastrin level was investigated in three patients with Zollinger-Ellison syndrome (ZES) and in 14 normal subjects.	Epinephrine	14-25	gastrin	Homo sapiens	40-47
2155479-3	1990	A significant increase in plasma gastrin, from 23 +/- 5 pg/ml to 53 +/- 20 pg/ml, in response to intravenous epinephrine (40 ng/kg.min), was observed in the normal subjects.	Epinephrine	109-120	gastrin	Homo sapiens	33-40
2155479-5	1990	In the ZES patients, epinephrine (40 ng/kg.min) also resulted in an increase in the plasma concentration of gastrin.	Epinephrine	21-32	gastrin	Homo sapiens	108-115
2155479-7	1990	beta-Adrenergic blockade suppressed the epinephrine-stimulated gastrin release in these patients as well.	Epinephrine	40-51	gastrin	Homo sapiens	63-70
2155479-8	1990	Graded intravenous doses of epinephrine given to the ZES patients resulted in elevation of the plasma gastrin in a dose-dependent manner.	Epinephrine	28-39	gastrin	Homo sapiens	102-109
2155479-10	1990	A significant correlation between plasma gastrin and epinephrine during insulin hypoglycemia was observed in both groups.	Epinephrine	53-64	gastrin	Homo sapiens	41-48
2227123-6	1990	Moreover, although intravenous injection of CGRP (5.67 nmol/kg) elicited a significant increase in plasma epinephrine and norepinephrine concentrations, concomitant administration of epinephrine and norepinephrine, inducing a more prominent rise in plasma catecholamines than those induced by CGRP, affected neither plasma glucose nor insulin levels.	Epinephrine	125-136	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
2154117-2	1990	Infusion of isoproterenol and epinephrine, but not of norepinephrine, acutely increased MNL beta-AR density, and this was blocked by the beta 2-selective antagonist ICI 118,551 but not by the beta 1-selective antagonist bisoprolol, suggesting a beta 2-AR-mediated effect.	Epinephrine	30-41	adrenoceptor beta 2	Homo sapiens	245-254
2405715-2	1990	The present work assessed the extent to which endogenously formed angiotensin II influences this neurally mediated adrenal epinephrine release.	Epinephrine	123-134	angiotensinogen	Rattus norvegicus	66-80
2405715-3	1990	The augmented release of epinephrine in rats maintained on the low-sodium diet appeared to depend on circulating angiotensin II because blockade of angiotensin II receptors with saralasin decreased the epinephrine release in these animals but not in rats maintained on the normal diet.	Epinephrine	25-36	angiotensinogen	Rattus norvegicus	113-127
2405715-3	1990	The augmented release of epinephrine in rats maintained on the low-sodium diet appeared to depend on circulating angiotensin II because blockade of angiotensin II receptors with saralasin decreased the epinephrine release in these animals but not in rats maintained on the normal diet.	Epinephrine	25-36	angiotensinogen	Rattus norvegicus	148-162
2405715-7	1990	These results demonstrate that endogenous angiotensin II is capable of providing a positive modulatory influence on neurally mediated release of adrenal epinephrine, an effect that may require a chronic activation of the renin-angiotensin system as occurs naturally with restricted dietary sodium intake.	Epinephrine	153-164	angiotensinogen	Rattus norvegicus	42-56
2405715-7	1990	These results demonstrate that endogenous angiotensin II is capable of providing a positive modulatory influence on neurally mediated release of adrenal epinephrine, an effect that may require a chronic activation of the renin-angiotensin system as occurs naturally with restricted dietary sodium intake.	Epinephrine	153-164	renin	Rattus norvegicus	221-226
2369145-2	1990	In the brain and adrenal medulla the enzyme phenylethanolamine-N-methyltransferase synthesizes epinephrine, but the skin epinephrine forming enzyme was an N-methyltransferase distinct from phenylethanolamine-N-methyltransferase.	Epinephrine	95-106	phenylethanolamine-N-methyltransferase	Rattus norvegicus	44-82
2201297-2	1990	In control animals, a loss of insulin receptor activity was found with cellular ageing and increased levels of norepinephrine, epinephrine and glycosylated hemoglobin.	Epinephrine	114-125	insulin receptor	Rattus norvegicus	30-46
2311372-1	1990	In young chickens plasma concentrations of growth hormone (GH) are depressed by prostaglandins (PG) E1 and E2, epinephrine, norepinephrine, alpha 2 and beta agonists or thyroid hormones.	Epinephrine	111-122	growth hormone	Gallus gallus	43-57
2311372-1	1990	In young chickens plasma concentrations of growth hormone (GH) are depressed by prostaglandins (PG) E1 and E2, epinephrine, norepinephrine, alpha 2 and beta agonists or thyroid hormones.	Epinephrine	111-122	growth hormone	Gallus gallus	59-61
2358061-1	1990	In experiments performed on female Wistar rats we have stated that simultaneously with glycogen mobilisation occurring immediately after epinephrine injection the amount of cytochrome P-450 (cP-450) was reduced.	Epinephrine	137-148	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	173-189
2358061-1	1990	In experiments performed on female Wistar rats we have stated that simultaneously with glycogen mobilisation occurring immediately after epinephrine injection the amount of cytochrome P-450 (cP-450) was reduced.	Epinephrine	137-148	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	191-197
2358061-4	1990	Glycogen and cP-450 loss and functional impairment depend on the administered epinephrine dose and time of treatment.	Epinephrine	78-89	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	13-19
2293574-4	1990	In contrast, adrenal homogenates, which N-methylate norepinephrine to form epinephrine using the enzyme phenylethanolamine-N-methyltransferase (PNMT), methylated dopamine only about 1% as well as norepinephrine.	Epinephrine	55-66	phenylethanolamine-N-methyltransferase	Rattus norvegicus	104-142
2293574-4	1990	In contrast, adrenal homogenates, which N-methylate norepinephrine to form epinephrine using the enzyme phenylethanolamine-N-methyltransferase (PNMT), methylated dopamine only about 1% as well as norepinephrine.	Epinephrine	55-66	phenylethanolamine-N-methyltransferase	Rattus norvegicus	144-148
11527136-7	1990	Under beta1/beta2-blockers, hypoglycemia could reactively lead to reflective pressure increases and bradycardia through epinephrine release.	Epinephrine	120-131	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	6-11
11527136-7	1990	Under beta1/beta2-blockers, hypoglycemia could reactively lead to reflective pressure increases and bradycardia through epinephrine release.	Epinephrine	120-131	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	12-17
1979356-1	1990	Thyrotropin-releasing hormone (TRH) could improve mean arterial pressure (MAP), myocardial contractile parameters (+/- dp/dtmax, Vpm and Vmax) and increase plasma epinephrine level significantly at 10 min after TRH administration in hemorrhagic shock rabbits, but the action of TRH on MAP and the myocardial contractility did not appear in rabbits pre-treated with reserpine (4 mg/kg, 24 h pre-treatment, i.v.).	Epinephrine	163-174	thyrotropin releasing hormone	Oryctolagus cuniculus	0-29
1979356-1	1990	Thyrotropin-releasing hormone (TRH) could improve mean arterial pressure (MAP), myocardial contractile parameters (+/- dp/dtmax, Vpm and Vmax) and increase plasma epinephrine level significantly at 10 min after TRH administration in hemorrhagic shock rabbits, but the action of TRH on MAP and the myocardial contractility did not appear in rabbits pre-treated with reserpine (4 mg/kg, 24 h pre-treatment, i.v.).	Epinephrine	163-174	thyrotropin releasing hormone	Oryctolagus cuniculus	31-34
1979356-6	1990	TRH stimulates sympathomedullary system to secrete epinephrine and sensitize the beta-receptors, but not alpha-receptors.	Epinephrine	51-62	thyrotropin releasing hormone	Oryctolagus cuniculus	0-3
2266783-1	1990	This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT.	Epinephrine	95-106	catechol-O-methyltransferase	Homo sapiens	25-53
2266783-1	1990	This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT.	Epinephrine	95-106	catechol-O-methyltransferase	Homo sapiens	55-59
2266783-1	1990	This modification of the catechol-O-methyltransferase (COMT) based radioenzymatic assay for norepinephrine (NE) and epinephrine (E) improves sensitivity, selectivity and eliminates many inhibitors of COMT.	Epinephrine	95-106	catechol-O-methyltransferase	Homo sapiens	200-204
1970437-3	1990	A leftward shift of the logarithmic dose-pressor response curve of (-)-adrenaline reflects beta 2-adrenoceptor-blocking properties.	Epinephrine	67-81	adrenoceptor beta 2	Rattus norvegicus	91-110
2154021-0	1990	Insulin inhibits the increased contractile force induced by epinephrine in isolated guinea pig heart muscle.	Epinephrine	60-71	insulin	Cavia porcellus	0-7
1981283-7	1990	Epinephrine, substance P and glutamate have all been hypothesized as primary chemical mediators in the descending pathway from the brain stem to SPN.	Epinephrine	0-11	DEAF1 transcription factor	Homo sapiens	145-148
2154021-6	1990	Insulin decreased the increased tension induced by epinephrine to 103.8% of control.	Epinephrine	51-62	insulin	Cavia porcellus	0-7
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Epinephrine	255-266	adrenoceptor beta 2	Homo sapiens	17-42
2105540-0	1990	Effect of exercise, DDAVP, and epinephrine on the factor VIII:C/von Willebrand factor complex in normal dogs and von Willebrand factor deficient Doberman pinscher dogs.	Epinephrine	31-42	von Willebrand factor	Canis lupus familiaris	64-85
34523094-11	2022	CAT activity was slightly increased when the concentration of epinephrine was higher.	Epinephrine	62-73	Catalase	Drosophila melanogaster	0-3
33801190-12	2021	Partial correlation (controlling for age, gender and Body Mass Index (BMI)) revealed a significant direct relation between MCP-1 and norepinephrine (r = 0.47, p = 0.03) and MCP-1 and epinephrine (r = 0.46, p = 0.04) in patients with -D+CAD at rest.	Epinephrine	136-147	C-C motif chemokine ligand 2	Homo sapiens	123-128
29576797-4	2018	We found that ALE inhibited IL-1beta secretion from NLRP3 inflammasome activated bone marrow derived macrophages but not that secreted by NLRC4 and AIM2 inflammasomes activation.	Epinephrine	14-17	interleukin 1 beta	Mus musculus	28-36
34767786-2	2021	The 3.2 A X-ray crystal structure of human beta2 AR active-state in combination with the endogenous low affinity agonist adrenaline offers an ideal starting structure for studying the binding of various catecholamines to adrenergic receptors.	Epinephrine	121-131	adenosine A2a receptor	Homo sapiens	43-51
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Epinephrine	255-266	adenosine A2a receptor	Homo sapiens	44-52
34767786-5	2021	Interestingly, re-docking neutral and protonated versions of adrenaline to rigid and flexible beta2 AR models results in binding poses that are more energetically stable and distinct from the X-ray crystal structure.	Epinephrine	61-71	adenosine A2a receptor	Homo sapiens	94-102
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Epinephrine	268-278	adrenoceptor beta 2	Homo sapiens	17-42
34767786-8	2021	SIGNIFICANCE The beta2-adrenergic receptor (beta2 AR), which belongs to the vast family of Guanine nucleotide-binding protein coupled receptors (GPCRs), is a transmembrane protein that is activated by the catecholamines norepinephrine (noradrenaline) and epinephrine (adrenaline).	Epinephrine	268-278	adenosine A2a receptor	Homo sapiens	44-52
34606571-2	2021	When epinephrine and antipsychotic drugs are administered in combination, beta-2 adrenergic effects are thought to predominate and induce hypotension.	Epinephrine	5-16	glycoprotein hormone subunit alpha 2	Homo sapiens	74-80
34907487-0	2021	Successful treatment of severe adrenaline-resistant anaphylactic shock with glucagon in a patient taking a beta-blocker: a case report.	Epinephrine	31-41	glucagon	Homo sapiens	76-84
34907487-2	2021	However, understanding the efficacy of glucagon is important because adrenaline-resistant anaphylactic shock is fatal.	Epinephrine	69-79	glucagon	Homo sapiens	39-47
34907487-3	2021	We present a case of severe adrenaline-resistant anaphylactic shock in a patient taking a beta-blocker, and glucagon was effective in improving hemodynamics.	Epinephrine	28-38	glucagon	Homo sapiens	108-116
34907487-9	2021	CONCLUSIONS: Glucagon may improve hemodynamics in adrenaline-resistant anaphylactic shock patients taking beta-blockers; however, its efficacy must be further evaluated in more cases.	Epinephrine	50-60	glucagon	Homo sapiens	13-21
34705304-5	2021	ABSTRACT: Background and aim : In skeletal muscle, glucose metabolism is tightly regulated by the reciprocal relationship between insulin and adrenaline with pyruvate being at the intersection of both pathways.	Epinephrine	142-152	insulin	Homo sapiens	130-137
34530005-4	2021	The inhibition study with quinidine clearly indicated that the decrease in secretory clearance of R-123 by adrenaline or the increase by DBcAMP would be attributed to the decrease or increase in P-gp activity, respectively.	Epinephrine	107-117	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	195-199
34530005-5	2021	Expression levels of P-gp in whole mucosal homogenates were not changed at all by any chemicals examined, but those on brush border membrane (BBM) of intestinal epithelial cells were significantly decreased or increased by adrenaline or DBcAMP, respectively.	Epinephrine	223-233	ATP binding cassette subfamily B member 1	Homo sapiens	21-25
34358845-10	2021	Remarkably, leptin treatment during either paradigm completely reversed this effect by normalizing glucagon levels in CR mice, 78.0 pmol/L (SD 47.3) (p = 0.764), and epinephrine levels in 3dRH rats, 2910 pg/mL (SD 1680) (p = 0.522).	Epinephrine	166-177	leptin	Mus musculus	12-18
34597667-6	2021	Therefore, we developed a mathematical model that also includes adiponectin exocytosis stimulated by extracellular epinephrine or the beta3AR agonist CL 316,243.	Epinephrine	115-126	adiponectin, C1Q and collagen domain containing	Homo sapiens	64-75
34480587-4	2021	Based on these results, we propose that the PHD2-HIF2alpha axis in the adrenal medulla regulates the synthesis of epinephrine, whereas in REPCs, it indirectly induces the release of this hormone.	Epinephrine	114-125	egl-9 family hypoxia-inducible factor 1	Mus musculus	44-48
34480587-4	2021	Based on these results, we propose that the PHD2-HIF2alpha axis in the adrenal medulla regulates the synthesis of epinephrine, whereas in REPCs, it indirectly induces the release of this hormone.	Epinephrine	114-125	endothelial PAS domain protein 1	Mus musculus	49-58
34480587-6	2021	KEY MESSAGES: HIF2alpha and not HIF1alpha modulates PNMT during epinephrine synthesis in chromaffin cells.	Epinephrine	64-75	phenylethanolamine N-methyltransferase	Homo sapiens	52-56
34503991-5	2021	In this study we exploited the technical ability to assay DOPAL and DOPEGAL simultaneously with the substrate catecholamines to compare DA, NE, and EPI in their metabolism by MAO-A and MAO-B.	Epinephrine	148-151	monoamine oxidase A	Homo sapiens	175-180
34503991-5	2021	In this study we exploited the technical ability to assay DOPAL and DOPEGAL simultaneously with the substrate catecholamines to compare DA, NE, and EPI in their metabolism by MAO-A and MAO-B.	Epinephrine	148-151	monoamine oxidase B	Homo sapiens	185-190
34503991-10	2021	Significance Statement Endogenous catecholamines are metabolized by monoamine oxidase (MAO)-A and -B, yielding the catecholaldehydes 3,4-dihydroxyphenylacetaldehyde (DOPAL) from dopamine (DA) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) from norepinephrine (NE) and epinephrine (EPI).	Epinephrine	269-280	monoamine oxidase A	Homo sapiens	68-100
34503991-10	2021	Significance Statement Endogenous catecholamines are metabolized by monoamine oxidase (MAO)-A and -B, yielding the catecholaldehydes 3,4-dihydroxyphenylacetaldehyde (DOPAL) from dopamine (DA) and 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL) from norepinephrine (NE) and epinephrine (EPI).	Epinephrine	282-285	monoamine oxidase A	Homo sapiens	68-100
34265230-9	2021	Frequent epinephrine was associated with increased odds of survival with favorable neurobehavioral outcome (aOR 2.56; CI95 1.07, 6.14; p=0.036), with 66% of the association mediated by CPR duration.	Epinephrine	9-20	cytochrome p450 oxidoreductase	Homo sapiens	185-188
34265230-12	2021	Mediation analysis suggests improved outcomes are largely due to frequent epinephrine shortening duration of CPR.	Epinephrine	74-85	cytochrome p450 oxidoreductase	Homo sapiens	109-112
34600046-7	2021	Sodium carbonate (Na Carb) 0.75% was the most efficient buffer to modify Epi solution pH to 8.0.	Epinephrine	73-76	syntaxin 8	Homo sapiens	21-25
34899395-3	2021	These results indicated that in fed rats an increased adrenergic tonus blocked food intake, since the activation of alpha-2 auto-receptors, which decreases pre-synaptic release of adrenaline/noradrenaline, affected food intake.	Epinephrine	180-190	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	116-123
34766341-8	2022	Adrenaline had no effect in tumor-bearing beta1beta2-AR knockout mice, in which beta1- and beta2-ARs are lacking, but it reduced tumor growth when co-administered with propranolol suggesting that tumor beta2-ARs negatively regulate adrenaline antitumor activity.	Epinephrine	232-242	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	202-207
34988191-3	2021	Propranolol is a non-selective beta2-AR blocker that was shown to inhibit demethylation adrenaline-induced Jagged1 expression.	Epinephrine	88-98	jagged canonical Notch ligand 1	Homo sapiens	107-114
34480587-0	2021	HIF2alpha regulates the synthesis and release of epinephrine in the adrenal medulla.	Epinephrine	49-60	endothelial PAS domain protein 1	Homo sapiens	0-9
34480587-2	2021	Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis.	Epinephrine	270-281	egl-9 family hypoxia-inducible factor 1	Mus musculus	104-108
34480587-2	2021	Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis.	Epinephrine	270-281	endothelial PAS domain protein 1	Mus musculus	152-161
34480587-2	2021	Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis.	Epinephrine	270-281	phenylethanolamine-N-methyltransferase	Mus musculus	184-222
34480587-2	2021	Here, we reveal that deficiency of HIF (hypoxia inducible factors) prolyl hydroxylase domain protein-2 (PHD2) in the adrenal medulla of mice results in HIF2alpha-mediated reduction in phenylethanolamine N-methyltransferase (PNMT) expression, and consequent reduction in epinephrine synthesis.	Epinephrine	270-281	phenylethanolamine-N-methyltransferase	Mus musculus	224-228
34480587-3	2021	Simultaneous loss of PHD2 in renal erythropoietin (EPO)-producing cells (REPCs) stimulated HIF2alpha-driven EPO overproduction, excessive RBC formation (erythrocytosis), and systemic hypoglycemia, which is necessary and sufficient to enhance exocytosis of epinephrine from the adrenal medulla.	Epinephrine	256-267	egl-9 family hypoxia-inducible factor 1	Mus musculus	21-25
34480587-3	2021	Simultaneous loss of PHD2 in renal erythropoietin (EPO)-producing cells (REPCs) stimulated HIF2alpha-driven EPO overproduction, excessive RBC formation (erythrocytosis), and systemic hypoglycemia, which is necessary and sufficient to enhance exocytosis of epinephrine from the adrenal medulla.	Epinephrine	256-267	erythropoietin	Homo sapiens	35-49
34480587-3	2021	Simultaneous loss of PHD2 in renal erythropoietin (EPO)-producing cells (REPCs) stimulated HIF2alpha-driven EPO overproduction, excessive RBC formation (erythrocytosis), and systemic hypoglycemia, which is necessary and sufficient to enhance exocytosis of epinephrine from the adrenal medulla.	Epinephrine	256-267	erythropoietin	Homo sapiens	51-54
34663067-1	2021	The beta2-adrenergic receptor (beta2AR) is a G-protein-coupled receptor (GPCR) that responds to the hormone adrenaline and is an important drug target in the context of respiratory diseases, including asthma.	Epinephrine	108-118	adrenoceptor beta 2	Homo sapiens	4-29
34663067-1	2021	The beta2-adrenergic receptor (beta2AR) is a G-protein-coupled receptor (GPCR) that responds to the hormone adrenaline and is an important drug target in the context of respiratory diseases, including asthma.	Epinephrine	108-118	adenosine A2a receptor	Homo sapiens	31-38
34591699-2	2021	Supplementation with ALE suppressed the NAFLD-induced increases in serum lipids, bilirubin, gamma-glutamyl transferase, aspartate transaminase (AST), and alanine aminotransferase.	Epinephrine	21-24	solute carrier family 17 member 5	Homo sapiens	120-142
34591699-2	2021	Supplementation with ALE suppressed the NAFLD-induced increases in serum lipids, bilirubin, gamma-glutamyl transferase, aspartate transaminase (AST), and alanine aminotransferase.	Epinephrine	21-24	solute carrier family 17 member 5	Homo sapiens	144-147
34591699-2	2021	Supplementation with ALE suppressed the NAFLD-induced increases in serum lipids, bilirubin, gamma-glutamyl transferase, aspartate transaminase (AST), and alanine aminotransferase.	Epinephrine	21-24	glutamic--pyruvic transaminase	Homo sapiens	154-178
34399896-8	2021	The method detection limits were 0.06, 0.16, 0.03 and 0.14 ng mL-1 for norepinephrine, epinephrine, dopamine and isoprenaline, respectively, and relative recoveries for these catecholamines were in the range of 98.56-108.1%, 92.56-110.0%, 98.79-112.3% and 88.14-97.81%, respectively.	Epinephrine	87-98	L1 cell adhesion molecule	Mus musculus	62-66
34160117-12	2021	DENV NS1 induce a stable platelet aggregation after the addition of a minimal dose of adenosine diphosphate (ADP), epinephrine (EPI) and collagen.	Epinephrine	115-126	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	5-8
34160117-12	2021	DENV NS1 induce a stable platelet aggregation after the addition of a minimal dose of adenosine diphosphate (ADP), epinephrine (EPI) and collagen.	Epinephrine	128-131	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	5-8
34215048-3	2021	A sensitive sensor for electrochemical detection of epinephrine (EP) was developed with GCE modified by OMC-NiO nanocomposite.	Epinephrine	52-63	epiregulin	Homo sapiens	65-67
34155498-11	2021	CONCLUSION: miR-16 and miR-26a sensitise the heart to TTS-like changes produced by adrenaline.	Epinephrine	83-93	glycerophosphodiester phosphodiesterase 1	Homo sapiens	12-18
34165128-8	2021	Higher expressions of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 (HO-1) were induced by the HFHC diet; however, ALE treatment reduced HO-1 expression.	Epinephrine	134-137	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-65
34165128-8	2021	Higher expressions of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 (HO-1) were induced by the HFHC diet; however, ALE treatment reduced HO-1 expression.	Epinephrine	134-137	heme oxygenase 1	Mus musculus	70-86
34165128-8	2021	Higher expressions of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 (HO-1) were induced by the HFHC diet; however, ALE treatment reduced HO-1 expression.	Epinephrine	134-137	heme oxygenase 1	Mus musculus	156-160
34436086-1	2021	This work demonstrates the analysis of epinephrine (EP) and uric acid (UA) in a single drop (the volume of the test solution was only 50 microL) using a screen-printed carbon electrode (SPCE) sensor and square-wave voltammetry (SWV).	Epinephrine	39-50	epiregulin	Homo sapiens	52-54
34355529-8	2021	Adrenaline, noradrenaline, and phenylephrine were highly efficacious alpha1-agonists at all three receptor subtypes.	Epinephrine	0-10	immunoglobulin kappa variable 2D-30	Homo sapiens	69-75
34260097-2	2021	The well-known tryptophan64arginine polymorphism of the ADRB3 gene alters the response of the receptor to various stimuli, including adrenalin and noradrenalin, and may increase the susceptibility to develop overactive bladder (OAB).	Epinephrine	133-142	adrenoceptor beta 3	Homo sapiens	56-61
34417460-6	2021	Glucagon, adrenaline and glucocorticoids augment protein levels of p53, and administration of these hormones to p53 deficient human hepatocytes and to liver-specific p53 deficient mice fails to increase glucose levels.	Epinephrine	10-20	tumor protein p53	Homo sapiens	67-70
34483927-2	2021	The mechanism of its occurrence is related to the aberrant release of Ca2+ from cardiomyocytes caused by abnormal RyR2 channels or CASQ2 proteins under conditions of sympathetic excitation, thus inducing a delayed posterior exertional pole, manifested by sympathetic excitation inducing adrenaline secretion, resulting in bidirectional or polymorphic ventricular tachycardia.	Epinephrine	287-297	ryanodine receptor 2	Homo sapiens	114-118
34367696-1	2021	Purpose: The dynamic state of epinephrine (Ep) in the plasma of patients with out-of-hospital cardiac arrest (OHCA) remains unclear.	Epinephrine	30-41	epiregulin	Homo sapiens	43-45
34367696-2	2021	The purpose of this study was to evaluate the relationship between the plasma levels of catecholamines (such as epinephrine (Ep), norepinephrine (Nep), and dopamine) and vasopressin (antidiuretic hormone (ADH)) and the acquisition of return of spontaneous circulation (ROSC) in OHCA patients.	Epinephrine	112-123	epiregulin	Homo sapiens	125-127
34320663-6	2022	Generally, mutations that lead to stabilization of HIF2alpha result in distinct catecholamine phenotype through blockade of glucocorticoid-mediated induction of phenylethanolamine N-methyltransferase, leading to the formation of tumors that lack epinephrine.	Epinephrine	246-257	endothelial PAS domain protein 1	Homo sapiens	51-60
34381974-4	2021	Mechanistically, upon recognizing its ligand, Nod1 localizes to DCGs, and recruits Rab2a, which is critical for Chga and epinephrine retention in DCGs.	Epinephrine	121-132	nucleotide-binding oligomerization domain containing 1	Mus musculus	46-50
34381974-4	2021	Mechanistically, upon recognizing its ligand, Nod1 localizes to DCGs, and recruits Rab2a, which is critical for Chga and epinephrine retention in DCGs.	Epinephrine	121-132	RAB2A, member RAS oncogene family	Mus musculus	83-88
34381974-5	2021	Depletion of Nod1 ligand or deficiency of Nod1 leads to a profound defect in epinephrine storage in chromaffin cells and subsequently less secretion upon stimulation.	Epinephrine	77-88	nucleotide-binding oligomerization domain containing 1	Mus musculus	13-17
34381974-5	2021	Depletion of Nod1 ligand or deficiency of Nod1 leads to a profound defect in epinephrine storage in chromaffin cells and subsequently less secretion upon stimulation.	Epinephrine	77-88	nucleotide-binding oligomerization domain containing 1	Mus musculus	42-46
34214097-2	2021	Keratinocyte migration, and wound epithelialization are decreased when beta 2-adrenergic receptors (B2AR) are activated by 1 muM epinephrine/adrenaline, resulting in delayed wound healing in human and mouse skin.	Epinephrine	129-140	adrenoceptor beta 2	Homo sapiens	100-104
34214097-2	2021	Keratinocyte migration, and wound epithelialization are decreased when beta 2-adrenergic receptors (B2AR) are activated by 1 muM epinephrine/adrenaline, resulting in delayed wound healing in human and mouse skin.	Epinephrine	141-151	adrenoceptor beta 2	Homo sapiens	100-104
34214097-7	2021	Phosphorylation of ERK was elevated after 1-10 minutes of the low epinephrine treatment and the A2B-AR inhibitor blocked the ERK phosphorylation.	Epinephrine	66-77	mitogen-activated protein kinase 1	Homo sapiens	19-22
34214097-8	2021	The results suggest that both the A2B-AR and B2AR mediate keratinocyte migration, in which with a low level of epinephrine treatment, A2B-AR could alter the B2AR signals and regulate the migration rate.	Epinephrine	111-122	adrenoceptor beta 2	Homo sapiens	45-49
34214097-8	2021	The results suggest that both the A2B-AR and B2AR mediate keratinocyte migration, in which with a low level of epinephrine treatment, A2B-AR could alter the B2AR signals and regulate the migration rate.	Epinephrine	111-122	adrenoceptor beta 2	Homo sapiens	157-161
34155498-4	2021	METHODS AND RESULTS: miR-16 and miR-26a were co-overexpressed in rats with AAV and TTS induced with an adrenaline bolus.	Epinephrine	103-113	microRNA 16	Rattus norvegicus	21-27
34155498-4	2021	METHODS AND RESULTS: miR-16 and miR-26a were co-overexpressed in rats with AAV and TTS induced with an adrenaline bolus.	Epinephrine	103-113	microRNA 26a	Rattus norvegicus	32-39
34155498-7	2021	In vitro miR-16 and/or miR-26a overexpression in isolated apical (but not basal) cardiomyocytes produced strong depression of contraction, with loss of adrenaline sensitivity.	Epinephrine	152-162	microRNA 16	Rattus norvegicus	9-15
34155498-11	2021	CONCLUSION: miR-16 and miR-26a sensitise the heart to TTS-like changes produced by adrenaline.	Epinephrine	83-93	microRNA 26a-1	Homo sapiens	23-30
34104996-8	2021	With the proposed method, the linearity range was from 0.500 to 500 ng mL-1 for norepinephrine and epinephrine and from 1.00 to 500 ng mL-1 for dopamine.	Epinephrine	99-110	L1 cell adhesion molecule	Mus musculus	71-75
34104996-9	2021	The detection limits were 0.050, 0.11, and 0.20 ng mL-1 for norepinephrine, epinephrine, and dopamine, respectively.	Epinephrine	76-87	L1 cell adhesion molecule	Mus musculus	51-55
34083626-3	2021	We found that senior investors display higher gray matter volume and increased structural brain connectivity in dopamine-related pathways, as well as a set of genes functionally associated with adrenaline and noradrenaline biosynthesis (SLC6A3, TH and SLC18A2), which is seemingly involved in reward processing and bodily stress responses during financial trading.	Epinephrine	194-204	solute carrier family 6 member 3	Homo sapiens	237-243
34189500-8	2021	A significant effect were observed on a white blood cells, epinephrine and cortisol concentrations were reduced in piglets fed diets containing E. coli challenge with lysozyme and antibiotics supplementation comparison with the NC group.	Epinephrine	59-70	lysozyme C-3	Sus scrofa	167-175
34071501-0	2021	Pancreatic Islets Exhibit Dysregulated Adaptation of Insulin Secretion after Chronic Epinephrine Exposure.	Epinephrine	85-96	LOC105613195	Ovis aries	53-60
34066786-6	2021	As a stress reaction, wounded epithelial cells release the hormone adrenaline (epinephrine), which activates the beta2-adrenergic receptor (beta2-AR), impairing the migration ability of keratinocytes and thus re-epithelization.	Epinephrine	67-77	adrenoceptor beta 2	Homo sapiens	113-138
34066786-6	2021	As a stress reaction, wounded epithelial cells release the hormone adrenaline (epinephrine), which activates the beta2-adrenergic receptor (beta2-AR), impairing the migration ability of keratinocytes and thus re-epithelization.	Epinephrine	67-77	adenosine A2a receptor	Homo sapiens	140-148
34066786-6	2021	As a stress reaction, wounded epithelial cells release the hormone adrenaline (epinephrine), which activates the beta2-adrenergic receptor (beta2-AR), impairing the migration ability of keratinocytes and thus re-epithelization.	Epinephrine	79-90	adrenoceptor beta 2	Homo sapiens	113-138
34066786-6	2021	As a stress reaction, wounded epithelial cells release the hormone adrenaline (epinephrine), which activates the beta2-adrenergic receptor (beta2-AR), impairing the migration ability of keratinocytes and thus re-epithelization.	Epinephrine	79-90	adenosine A2a receptor	Homo sapiens	140-148
34449427-0	2021	BET 1: Topical epinephrine in postcircumcision bleeding.	Epinephrine	15-26	Bet1 golgi vesicular membrane trafficking protein	Homo sapiens	0-5
35618032-9	2022	Adrenal epinephrine biosynthesis gene, Pnmt, was induced after ozone exposure at both timepoints.	Epinephrine	8-19	phenylethanolamine-N-methyltransferase	Rattus norvegicus	39-43
35452328-1	2022	SignificanceWe report the detailed atomistic mechanism for how molecules such as morphine, dopamine, or epinephrine binding outside of a cell to a G protein-coupled receptor (GPCR) in the cell membrane cause a G protein (GP) bound at the inside of the cell to break apart and signal the cell to influence appetite, anxiety, memory, cognition, learning, and sleep.	Epinephrine	104-115	ring finger protein 130	Homo sapiens	147-156
35452328-1	2022	SignificanceWe report the detailed atomistic mechanism for how molecules such as morphine, dopamine, or epinephrine binding outside of a cell to a G protein-coupled receptor (GPCR) in the cell membrane cause a G protein (GP) bound at the inside of the cell to break apart and signal the cell to influence appetite, anxiety, memory, cognition, learning, and sleep.	Epinephrine	104-115	ring finger protein 130	Homo sapiens	210-219
35452328-1	2022	SignificanceWe report the detailed atomistic mechanism for how molecules such as morphine, dopamine, or epinephrine binding outside of a cell to a G protein-coupled receptor (GPCR) in the cell membrane cause a G protein (GP) bound at the inside of the cell to break apart and signal the cell to influence appetite, anxiety, memory, cognition, learning, and sleep.	Epinephrine	104-115	ring finger protein 130	Homo sapiens	221-223
34985191-7	2022	CST reduced plasma NE and EPI levels.	Epinephrine	26-29	cystatin 12, pseudogene	Homo sapiens	0-3
34985191-8	2022	CST also directly stimulated glycogenesis and inhibited NE and EPI-induced glycogenolysis in hepatocytes.	Epinephrine	63-66	cystatin 12, pseudogene	Homo sapiens	0-3
34104992-3	2021	One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine.	Epinephrine	238-249	OCTN3	Homo sapiens	139-167
34104992-3	2021	One such mechanism involves the direct inhibition by corticosteroid hormones of monoamine transport mediated by the "uptake2" transporter, organic cation transporter 3 (OCT3), a high-capacity, low-affinity transporter for norepinephrine, epinephrine, dopamine, serotonin, and histamine.	Epinephrine	238-249	OCTN3	Homo sapiens	169-173
35174415-3	2022	Aims of the study were to monitor the effect of a single session of dTMS on body temperature in subjects with obesity, and to correlate the dTMS-induced changes in body temperature with activation of the SNS (epinephrine and norepinephrine release).	Epinephrine	209-220	tms	Drosophila melanogaster	140-144
35189708-0	2022	Expression of LHCGR (Luteinizing Hormone/Chorionic Gonadotrophin Receptor) in Pheochromocytomas Unveils an Endocrine Mechanism Connecting Pregnancy and Epinephrine Overproduction.	Epinephrine	152-163	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	14-19
35290616-0	2022	Influence of exogenous adrenaline on insulin sensitivity under general anesthesia in canine model: a preliminary study.	Epinephrine	23-33	insulin	Canis lupus familiaris	37-44
35189708-0	2022	Expression of LHCGR (Luteinizing Hormone/Chorionic Gonadotrophin Receptor) in Pheochromocytomas Unveils an Endocrine Mechanism Connecting Pregnancy and Epinephrine Overproduction.	Epinephrine	152-163	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	21-73
35189708-4	2022	METHODS: In vitro studies were conducted to investigate the effect of estradiol and the pregnancy hormone hCG (human chorionic gonadotropin) on epinephrine secretion by cultured cells derived from the patient"s tumor.	Epinephrine	144-155	cathepsin G	Homo sapiens	106-109
35189708-7	2022	RESULTS: hCG stimulated epinephrine secretion by cultured cells derived from the patient"s pheochromocytoma.	Epinephrine	24-35	cathepsin G	Homo sapiens	9-12
35189708-11	2022	CONCLUSIONS: Pregnancy may thus favor surges in plasma catecholamine and hypertensive crises through hCG-induced stimulation of epinephrine production by pheochromocytomas.	Epinephrine	128-139	cathepsin G	Homo sapiens	101-104
35393054-6	2022	In the B-strain TCCs, five SNPs within NDUFA8 and DAB2IP had significant effects on plasma adrenaline and corticosterone levels, and six SNPs within TRPC1, SLC9A9, and TRPC7 markedly affected plasma corticosterone and triiodothyronine levels.	Epinephrine	91-101	NADH:ubiquinone oxidoreductase subunit A8	Gallus gallus	39-45
35397615-10	2022	In the CSF neurogranin positively associated with noradrenaline and adrenaline but not with dopamine.	Epinephrine	68-78	neurogranin	Homo sapiens	11-22
35391571-1	2022	Dopamine (DA), epinephrine (EP), and norepinephrine (NEP) are the main catecholamine of clinical interest, as they play crucial roles in the regulation of nervous and cardiovascular systems and are involved in some brain behaviors, such as stress, panic, anxiety, and depression.	Epinephrine	15-26	epiregulin	Homo sapiens	28-30
35393054-6	2022	In the B-strain TCCs, five SNPs within NDUFA8 and DAB2IP had significant effects on plasma adrenaline and corticosterone levels, and six SNPs within TRPC1, SLC9A9, and TRPC7 markedly affected plasma corticosterone and triiodothyronine levels.	Epinephrine	91-101	DAB2 interacting protein	Gallus gallus	50-56
35267019-7	2022	Rev-erbalpha deletion also reduced ferric chloride-induced carotid arterial occlusive thrombosis, prevented collagen/epinephrine-induced pulmonary thromboembolism, and protected against microvascular microthrombi obstruction and infarct expansion in an acute myocardial infarction model.	Epinephrine	117-128	nuclear receptor subfamily 1, group D, member 1	Mus musculus	0-12
2575009-1	1989	Adrenergic input to the rat substantia innominata (SI) was studied by immunocytochemical localization of phenylethanolamine N-methyltransferase (PNMT), the synthetic enzyme for adrenaline.	Epinephrine	177-187	phenylethanolamine-N-methyltransferase	Rattus norvegicus	105-143
35245122-1	2022	The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs.	Epinephrine	243-254	adrenoceptor alpha 2A	Homo sapiens	4-31
35245122-1	2022	The alpha2A adrenergic receptor (alpha2AAR) is a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that mediates important physiological functions in response to the endogenous neurotransmitters norepinephrine and epinephrine, as well as numerous chemically distinct drugs.	Epinephrine	243-254	adrenoceptor alpha 2A	Homo sapiens	33-42
34772856-8	2022	Furthermore, urinary excretion of adrenaline and noradrenaline by fld mice was significantly higher compared with that of control mice.	Epinephrine	34-44	lipin 1	Mus musculus	66-69
35041075-4	2022	It is mediated by morning increases in epinephrine, leading to a mobilization of these cells out of the marginal pool into the circulation following a fast, beta2-adrenoceptor-dependent inhibition of adhesive integrin signaling.	Epinephrine	39-50	adrenoceptor beta 2	Homo sapiens	157-175
35070058-10	2022	Catalase and the phosphoinositide 3-kinase inhibitor wortmannin inhibited adrenaline-induced activation of 2-DG uptake.	Epinephrine	74-84	catalase	Homo sapiens	0-8
35269975-4	2022	Here, we show that in vivo thrombus formation after FeCl3 injury of the carotid artery was delayed in Pcyox1-/- mice, which were also protected from collagen/epinephrine induced thromboembolism.	Epinephrine	158-169	prenylcysteine oxidase 1	Mus musculus	102-108
34582994-10	2022	Among the 14 patients with failed AV cannulation, 3 patients would have been considered to have successful AVS using AV epinephrine levels >364 pg/mL and AV/IVC epinephrine ratio >27.4 thresholds.	Epinephrine	120-131	thrombopoietin	Mus musculus	147-149
35284140-6	2022	In addition, despite no significant correlations between plasma levels of NGF and catecholamines in both groups, urinary NGF significantly correlated positively with both urinary noradrenaline and urinary adrenaline in the hypertensive group (r = 0.259, p=0.018 and r = 0.232, p=0.035), but not in the normotensive group (r = 0.115, p=0.307 and r = -0.018, p=0.871).	Epinephrine	205-215	nerve growth factor	Homo sapiens	121-124
35187102-6	2021	Results: High concentration Epi and two dopamine D1/D5 receptor agonists ((+-)-SKF 38393 and fenoldopam) reduced the depolarization velocity and prolonged the duration of action potentials (APs) and caused arrhythmic events in iPSC-CMs, suggesting involvement of dopamine D1/D5 receptor signaling in arrhythmogenesis associated with QT interval prolongation in the setting of TTC.	Epinephrine	28-31	dopamine receptor D1	Homo sapiens	263-286
35051185-5	2022	During spontaneous atrial contraction, PKD2L1del-Tg atria showed enhanced sensitivity to isoproterenol, norepinephrine, and epinephrine.	Epinephrine	124-135	polycystic kidney disease 2-like 1	Mus musculus	39-45
35070058-5	2022	RESULTS: In human adipocytes, 45-min incubation with 100 micromol/L adrenaline or noradrenaline activated 2-DG uptake up to more than one-third of the maximal response to insulin.	Epinephrine	68-78	insulin	Homo sapiens	171-178
2617459-0	1989	Platelet mobilization induced by PAF and its role in the thrombocytosis triggered by adrenaline in rats.	Epinephrine	85-95	PCNA clamp associated factor	Rattus norvegicus	33-36
2617459-7	1989	Desensitization to PAF or pretreatment with PAF antagonists clearly prevented the increase in the platelet counts after stimulation by adrenaline (15 micrograms/kg).	Epinephrine	135-145	PCNA clamp associated factor	Rattus norvegicus	19-22
2617459-7	1989	Desensitization to PAF or pretreatment with PAF antagonists clearly prevented the increase in the platelet counts after stimulation by adrenaline (15 micrograms/kg).	Epinephrine	135-145	PCNA clamp associated factor	Rattus norvegicus	44-47
2617459-8	1989	These findings suggest that, in rats, PAF can induce release of platelets by a spleen-dependent mechanism and that this lipid may be relevant to the thrombocytosis triggered by adrenaline.	Epinephrine	177-187	PCNA clamp associated factor	Rattus norvegicus	38-41
2557776-8	1989	The effect of ethanol on PAF-induced platelet aggregation shows a selectivity similar to that demonstrated by other investigators for epinephrine and adenosine diphosphate.	Epinephrine	134-145	PCNA clamp associated factor	Homo sapiens	25-28
2558573-2	1989	CGRP lowered diastolic blood pressure by 26% and increased the heart rate by 35% and raised plasma levels of norepinephrine, epinephrine, and dopamine and renin activity (P less than 0.01).	Epinephrine	112-123	calcitonin related polypeptide alpha	Homo sapiens	0-4
2575009-1	1989	Adrenergic input to the rat substantia innominata (SI) was studied by immunocytochemical localization of phenylethanolamine N-methyltransferase (PNMT), the synthetic enzyme for adrenaline.	Epinephrine	177-187	phenylethanolamine-N-methyltransferase	Rattus norvegicus	145-149
2597194-4	1989	The bull testis PST and both boar testis enzymes were active with p-nitrophenol and adrenalin.	Epinephrine	84-93	sulfotransferase family 1A member 1	Homo sapiens	16-19
2558700-13	1989	In vitro, lymphocytes showed increased beta 2-responsiveness after 30 min of adrenaline infusion (delta cyclic AMP increased from 1.86 +/- 0.24 to 3.06 +/- 0.58 pmol/10(6) cells), but a decreased response (0.47 +/- 0.10 pmol/10(6) cells) after 3 h of infusion.	Epinephrine	77-87	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-45
2558700-9	1989	Adrenaline infusion raised venous plasma adrenaline levels to 4-5 nmol l-1, increased heart rate by 14 +/- 3 beats min-1 and plasma cyclic AMP by 17 +/- 3 nmol l-1, and decreased diastolic blood pressure by 15 +/- 5 mm Hg.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	115-120
2611690-6	1989	Our results support the previous hypothesis of the dissociation between epinephrine present in the hypothalamus and hypothalamic PNMT activity.	Epinephrine	72-83	phenylethanolamine N-methyltransferase	Homo sapiens	129-133
2573552-4	1989	While adrenaline and the activity of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts noradrenaline to adrenaline, were present at Embryonic Day 17.3 (E17.3), they were not detectable in E16.3 adrenals.	Epinephrine	113-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	48-86
2532076-5	1989	During ANP infusion, the epinephrine-release rate declined by 26 +/- 5% per 10-fold elevation in plasma ANP before pacing and by 31 +/- 7% (not significantly different) after 2 weeks of pacing.	Epinephrine	25-36	natriuretic peptide A	Canis lupus familiaris	7-10
2532076-5	1989	During ANP infusion, the epinephrine-release rate declined by 26 +/- 5% per 10-fold elevation in plasma ANP before pacing and by 31 +/- 7% (not significantly different) after 2 weeks of pacing.	Epinephrine	25-36	natriuretic peptide A	Canis lupus familiaris	104-107
2532076-8	1989	These data indicate that, during the development of heart failure, an inhibitory action of ANP on norepinephrine release is unmasked by an ANP-specific vascular desensitization, whereas the inhibition of epinephrine release is observed throughout.	Epinephrine	101-112	natriuretic peptide A	Canis lupus familiaris	91-94
2605867-9	1989	The insulin concentrations in serum were elevated in the adrenaline group and the triple-hormone group, but not in the cortisol group.	Epinephrine	57-67	insulin	Homo sapiens	4-11
2573552-4	1989	While adrenaline and the activity of the enzyme phenylethanolamine N-methyltransferase (PNMT), which converts noradrenaline to adrenaline, were present at Embryonic Day 17.3 (E17.3), they were not detectable in E16.3 adrenals.	Epinephrine	113-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	88-92
2573510-3	1989	The iv or intracerebroventricular injection of either Il-1 alpha or Il-1 beta caused dose-related increases in plasma ACTH, epinephrine, and norepinephrine levels.	Epinephrine	124-135	interleukin 1 alpha	Rattus norvegicus	54-64
2573510-3	1989	The iv or intracerebroventricular injection of either Il-1 alpha or Il-1 beta caused dose-related increases in plasma ACTH, epinephrine, and norepinephrine levels.	Epinephrine	124-135	interleukin 1 beta	Rattus norvegicus	68-77
2573510-6	1989	Similarly, Il-1 alpha was more effective than Il-1 beta at stimulating epinephrine, but not norepinephrine, secretion after icv injection.	Epinephrine	71-82	interleukin 1 alpha	Rattus norvegicus	11-21
2573510-6	1989	Similarly, Il-1 alpha was more effective than Il-1 beta at stimulating epinephrine, but not norepinephrine, secretion after icv injection.	Epinephrine	71-82	interleukin 1 beta	Rattus norvegicus	46-55
2614337-4	1989	Dorsal aortic injections of epinephrine or norepinephrine increased plasma glucose (16-46%), had no effect on liver or muscle glycogen levels, decreased the activity of PK, and increased total and percent GPase a activities.	Epinephrine	28-39	pyruvate kinase PKM	Oncorhynchus mykiss	169-171
2572679-4	1989	The results suggest that the induced increase of adrenal TH activity, as mediated by certain drugs, results in an elevation of the plasma epinephrine level and that the adrenal dopamine content is a better indicator of the catecholamine-synthesizing capacity of the adrenal medulla than are the other catecholamines.	Epinephrine	138-149	tyrosine hydroxylase	Rattus norvegicus	57-59
2512185-2	1989	The intravenous administration of 50 micrograms of TRH produced an increase in plasma epinephrine, cerebral dopamine and a reciprocal decrease in norepinephrine and dopamine in diencephalon and midbrain.	Epinephrine	86-97	thyrotropin releasing hormone	Rattus norvegicus	51-54
2553251-2	1989	Epinephrine (Epi) and norepinephrine (NE) activated AH130 adenylate cyclase about half as much as isoproterenol (IPN) but equaled IPN after treatment with the alpha-antagonist phentolamine or islet-activating protein (IAP).	Epinephrine	0-11	magnesium transporter 1	Rattus norvegicus	192-216
2553251-2	1989	Epinephrine (Epi) and norepinephrine (NE) activated AH130 adenylate cyclase about half as much as isoproterenol (IPN) but equaled IPN after treatment with the alpha-antagonist phentolamine or islet-activating protein (IAP).	Epinephrine	0-11	magnesium transporter 1	Rattus norvegicus	218-221
2508793-0	1989	Activation of protein kinase C in platelets by epinephrine and A23187: correlation with fibrinogen binding.	Epinephrine	47-58	fibrinogen beta chain	Homo sapiens	88-98
2508793-7	1989	Thus, epinephrine and A23187 together activate PKC by a mechanism that does not require phospholipase C or enhanced binding of PKC to the plasma membrane; PKC activation in turn is correlated with enhanced platelet fibrinogen binding and aggregation.	Epinephrine	6-17	fibrinogen beta chain	Homo sapiens	215-225
2551657-1	1989	TSH-releasing factor (TRF), administered into the lateral cerebroventricle of adult male rats, elevated plasma concentrations of ACTH, epinephrine, and norepinephrine.	Epinephrine	135-146	thyrotropin releasing hormone	Rattus norvegicus	0-20
2551657-1	1989	TSH-releasing factor (TRF), administered into the lateral cerebroventricle of adult male rats, elevated plasma concentrations of ACTH, epinephrine, and norepinephrine.	Epinephrine	135-146	thyrotropin releasing hormone	Rattus norvegicus	22-25
2559238-3	1989	In normal subjects, plasma renin activity, coagulation factors and plasma cyclic AMP are stimulated not only by dDAVP but also by the administration of epinephrine.	Epinephrine	152-163	renin	Homo sapiens	27-32
2553215-2	1989	Centrally administered AII (100 ng/2 microliters) caused hypertension with elevation of the plasma epinephrine level.	Epinephrine	99-110	angiotensinogen	Rattus norvegicus	23-26
2558326-3	1989	Rats chronically cannulated in the right jugular veins showed a time-related increase in plasma corticosterone concentrations in response to intraperitoneal administration of IL-1 that lasted up to 4 h. In the same rats, plasma epinephrine (E) and norepinephrine (NE) concentrations were only slightly elevated (2-fold increase) at 30 min and at 1 h after IL-1 administration.	Epinephrine	228-239	interleukin 1 complex	Mus musculus	175-179
2813439-3	1989	Intracerebroventricular injection of norepinephrine (2 micrograms/rat) or epinephrine (100 ng and 1 microgram/rat) caused an increase in plasma PRL levels.	Epinephrine	40-51	prolactin	Rattus norvegicus	144-147
2813439-4	1989	The PRL increase induced by epinephrine was much greater than that by norepinephrine.	Epinephrine	28-39	prolactin	Rattus norvegicus	4-7
2813439-5	1989	Intracerebroventricular injection of phentolamine (1 microgram/rat), an alpha-antagonist, blunted the plasma PRL increase induced by epinephrine (100 ng intracerebroventricularly).	Epinephrine	133-144	prolactin	Rattus norvegicus	109-112
2783136-3	1989	In agreement with earlier views on the aggregation-dependency of weak agonist-induced thromboxane synthesis and 5-hydroxytryptamine (5HT) secretion, RGDS (100-300 microM) inhibited these events induced by ADP, adrenaline and low concentrations of thrombin and collagen but not that induced by high concentrations of thrombin and collagen.	Epinephrine	210-220	ral guanine nucleotide dissociation stimulator	Homo sapiens	149-153
2818580-0	1989	Epinephrine-activation of heparin-nonreleasable lipoprotein lipase in 3 skeletal muscle fiber types of the rat.	Epinephrine	0-11	lipoprotein lipase	Rattus norvegicus	48-66
2818580-1	1989	Epinephrine was used to activate the heparin non-releasable lipoprotein lipase (LPL) in the 3 skeletal muscle fiber types of the perfused rat hindlimb.	Epinephrine	0-11	lipoprotein lipase	Rattus norvegicus	60-78
2818580-1	1989	Epinephrine was used to activate the heparin non-releasable lipoprotein lipase (LPL) in the 3 skeletal muscle fiber types of the perfused rat hindlimb.	Epinephrine	0-11	lipoprotein lipase	Rattus norvegicus	80-83
2818580-3	1989	Activity of the residual LPL in soleus, red vastus lateralis, and white vastus lateralis muscles increased 75%, 96%, and 102% respectively, following epinephrine perfusion.	Epinephrine	150-161	lipoprotein lipase	Rattus norvegicus	25-28
2801884-3	1989	The IL-3-induced peripheral neutrophilia was accompanied by a decrease in mature marrow neutrophils, indicating that the mechanism of neutrophilia was through marrow release rather than by demargination, which occurs after the administration of epinephrine or IL-6.	Epinephrine	245-256	interleukin 3	Homo sapiens	4-8
2582730-7	1989	adrenaline infusion (0.02 microgram min-1 kg-1 body weight).	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	36-41
2582730-9	1989	Whole body oxygen uptake, carbon dioxide production, heart rate and plasma concentrations of free fatty acids (FFA) increased while the mean arterial pressure decreased significantly in response to adrenaline infusion at 0.02 microgram kg-1 min-1 in both weight-losing and weight-stable patients.	Epinephrine	198-208	CD59 molecule (CD59 blood group)	Homo sapiens	241-246
2582730-10	1989	Adrenaline at 0.005 microgram kg-1 min-1 increased plasma FFA levels by 19% (P less than 0.05) in weight-losing patients while no significant alteration was observed in well-nourished patients.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	35-40
2582730-11	1989	Adrenaline infusion at 0.02 microgram kg-1 min-1 decreased the mean arterial blood pressure and stimulated respiratory gas exchange and heart rate significantly more in weight-losing than in weight-stable patients.	Epinephrine	0-10	CD59 molecule (CD59 blood group)	Homo sapiens	43-48
2617081-1	1989	Using a complex stimulating mixture containing ADP, epinephrine and collagen, a significantly (p less than 0.002) enhanced platelet aggregability, expressed as platelet sensitivity factor (PSF) was noted in platelet rich plasma of patients with proteinuria (PSF = 472 +/- 125), as against normal weight normolipidemic control subjects (PSF = 32.76 +/- 2.67).	Epinephrine	52-63	insulin like growth factor binding protein 7	Homo sapiens	189-192
2617081-1	1989	Using a complex stimulating mixture containing ADP, epinephrine and collagen, a significantly (p less than 0.002) enhanced platelet aggregability, expressed as platelet sensitivity factor (PSF) was noted in platelet rich plasma of patients with proteinuria (PSF = 472 +/- 125), as against normal weight normolipidemic control subjects (PSF = 32.76 +/- 2.67).	Epinephrine	52-63	insulin like growth factor binding protein 7	Homo sapiens	258-261
2617081-1	1989	Using a complex stimulating mixture containing ADP, epinephrine and collagen, a significantly (p less than 0.002) enhanced platelet aggregability, expressed as platelet sensitivity factor (PSF) was noted in platelet rich plasma of patients with proteinuria (PSF = 472 +/- 125), as against normal weight normolipidemic control subjects (PSF = 32.76 +/- 2.67).	Epinephrine	52-63	insulin like growth factor binding protein 7	Homo sapiens	258-261
2528911-7	1989	The studies show that insulin-induced hypoglycemia was associated with a rise in plasma cortisol, beta-endorphin, epinephrine, norepinephrine, and glucagon.	Epinephrine	114-125	insulin	Canis lupus familiaris	22-29
2570461-3	1989	Exposure of eukaryotic cells transfected with this gene to adrenaline or noradrenaline promotes the accumulation of adenosine 3",5"-monophosphate; only 2 of 11 classical beta-AR blockers efficiently inhibited this effect, whereas two others behaved as beta 3-AR agonists.	Epinephrine	59-69	adrenoceptor beta 3	Homo sapiens	252-261
2782399-6	1989	The present study provides evidence of a facultative thermogenic component in skeletal muscle, mediated by epinephrine via beta 2-adrenoreceptors.	Epinephrine	107-118	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	123-129
2552996-2	1989	Glucagon (via cyclic AMP) and adrenaline (via cyclic AMP and alpha-effects) increased the binding of 125I-LDL to the LDL receptor, and the degradation of LDL to [125I]iodotyrosine.	Epinephrine	30-40	low density lipoprotein receptor	Rattus norvegicus	117-129
2504083-0	1989	Dose-dependent vasopressor response to epinephrine during CPR in human beings.	Epinephrine	39-50	cytochrome p450 oxidoreductase	Homo sapiens	58-61
2504083-1	1989	The optimal dose of epinephrine during CPR in human beings is unknown.	Epinephrine	20-31	cytochrome p450 oxidoreductase	Homo sapiens	39-42
2764320-0	1989	Epinephrine doses in cardiac arrest: is it time to outgrow the orthodoxy of ACLS?	Epinephrine	0-11	ACLS	Homo sapiens	76-80
2794119-3	1989	Light microscopy revealed immunoautoradiographic labeling for the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) in perikarya and processes in close proximity to cells demonstrating peroxidase reaction product for GABA.	Epinephrine	66-76	phenylethanolamine-N-methyltransferase	Rattus norvegicus	97-135
2759199-1	1989	Adrenaline (A) is synthesized in the adrenal medullae by the enzyme phenylethanolamine-N-methyltransferase (PNMT).	Epinephrine	0-10	phenylethanolamine N-methyltransferase	Homo sapiens	68-106
2759199-1	1989	Adrenaline (A) is synthesized in the adrenal medullae by the enzyme phenylethanolamine-N-methyltransferase (PNMT).	Epinephrine	0-10	phenylethanolamine N-methyltransferase	Homo sapiens	108-112
2776842-5	1989	The addition of 0.2-3.7 nmol NPY did not induce contraction in superfused helical segments of large coronary arteries but it potentiated the tension developed in response to 0.18 microM adrenaline in a concentration-dependent manner.	Epinephrine	186-196	neuropeptide Y	Canis lupus familiaris	29-32
2776842-6	1989	Pretreatment of these arteries with 3.7 nmol NPY caused a significant leftward displacement of the adrenaline contractile effect.	Epinephrine	99-109	neuropeptide Y	Canis lupus familiaris	45-48
2794119-3	1989	Light microscopy revealed immunoautoradiographic labeling for the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase (PNMT) in perikarya and processes in close proximity to cells demonstrating peroxidase reaction product for GABA.	Epinephrine	66-76	phenylethanolamine-N-methyltransferase	Rattus norvegicus	137-141
2752969-9	1989	Intra-adrenal application of Met-Enk reduced Ach-stimulated epinephrine, but not norepinephrine, secretion significantly; application of Nal did not affect Ach-stimulated catecholamine secretion in the initial fraction after Ach injection, but significantly prolonged amine secretion after the cholinergic stimulus.	Epinephrine	60-71	proenkephalin	Rattus norvegicus	33-36
2569829-1	1989	Epinephrine"s effect to increase metabolic rate is accompanied by changes in the plasma concentrations of insulin, glucagon, and metabolic substrates.	Epinephrine	0-11	insulin	Homo sapiens	106-113
2569829-2	1989	Because both glucagon and insulin have been reported to affect thermogenesis, these hormones might contribute to or modify the thermogenic response to epinephrine.	Epinephrine	151-162	insulin	Homo sapiens	26-33
2569829-7	1989	Also as expected, the glycemic response to epinephrine infusion was much larger when insulin and glucagon levels were fixed with the islet clamp (study C).	Epinephrine	43-54	insulin	Homo sapiens	85-92
2549387-3	1989	We found that alpha 1-adrenergic- and bradykinin-stimulated [3H]AA release can be distinguished by differential dependence on protein kinase C; epinephrine-stimulated release was more dependent on protein kinase C activation than was bradykinin-stimulated release.	Epinephrine	144-155	kininogen 1	Canis lupus familiaris	38-48
2526581-5	1989	ANP infusion also reduced (p less than 0.01) plasma NE responses to both levels of LBNP and tended to decrease both epinephrine and FVR during ANP infusion at -20 mm Hg LBNP (p = 0.8).	Epinephrine	116-127	natriuretic peptide A	Homo sapiens	0-3
2546796-0	1989	Potentiation by adrenaline of thrombin-induced elevation of pHi is not essential for synergistic activation of human platelets.	Epinephrine	16-26	coagulation factor II, thrombin	Homo sapiens	30-38
2546796-0	1989	Potentiation by adrenaline of thrombin-induced elevation of pHi is not essential for synergistic activation of human platelets.	Epinephrine	16-26	glucose-6-phosphate isomerase	Homo sapiens	60-63
2546796-2	1989	Adrenaline markedly enhanced the thrombin-induced increase in cytoplasmic pH (pHi) in BCECF-loaded platelets.	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	33-41
2546796-2	1989	Adrenaline markedly enhanced the thrombin-induced increase in cytoplasmic pH (pHi) in BCECF-loaded platelets.	Epinephrine	0-10	glucose-6-phosphate isomerase	Homo sapiens	78-81
2546796-4	1989	The potentiation by adrenaline of thrombin-induced PLC activation measured as [32P]PA formation and final platelet responses was, however, not blocked by EIPA, even at low concentrations of thrombin.	Epinephrine	20-30	coagulation factor II, thrombin	Homo sapiens	34-42
2546796-5	1989	These results indicate that the enhancement by adrenaline of thrombin-induced cytoplasmic alkalinization may be a secondary effect which is not essential for the potentiation by adrenaline of platelet activation by thrombin.	Epinephrine	47-57	coagulation factor II, thrombin	Homo sapiens	61-69
2804303-0	1989	[Prevention of adrenaline-induced arrhythmia by a calmodulin blocker, trifluoroperazine].	Epinephrine	15-25	calmodulin 1	Rattus norvegicus	50-60
2575886-3	1989	The negative inotropic effect of somatostatin was evaluated at different concentrations of extracellular calcium, on the positive inotropic response induced by calcium and on the positive chronotropic response induced by adrenaline.	Epinephrine	221-231	somatostatin	Cavia porcellus	33-45
2474415-10	1989	Adrenal medullary fibrosis may be an anatomical correlate of the diminished epinephrine secretion that occurs in response to insulin-induced hypoglycemia in some IDDM subjects.	Epinephrine	76-87	insulin	Homo sapiens	125-132
2583667-4	1989	By infusion of epinephrine (0.01 micrograms/min), myoglobin was deoxygenated concomitant with the increase of left ventricular pressure and heart heart rate increased.	Epinephrine	15-26	myoglobin	Rattus norvegicus	50-59
2472635-2	1989	We have demonstrated that epinephrine modulates both the rate of transcription of the beta 2-adrenergic receptor (beta 2AR) gene and the steady-state level of beta 2AR mRNA in DDT1MF-2 cells.	Epinephrine	26-37	beta-2 adrenergic receptor	Mesocricetus auratus	86-112
2472635-2	1989	We have demonstrated that epinephrine modulates both the rate of transcription of the beta 2-adrenergic receptor (beta 2AR) gene and the steady-state level of beta 2AR mRNA in DDT1MF-2 cells.	Epinephrine	26-37	beta-2 adrenergic receptor	Mesocricetus auratus	114-122
2557609-3	1989	Adrenergic agonists increased the cAMP levels in EPA in the order of potency characteristic for beta 2-AR: isoproterenol greater than epinephrine greater than norepinephrine.	Epinephrine	134-145	adrenoceptor beta 2	Homo sapiens	96-105
2472635-2	1989	We have demonstrated that epinephrine modulates both the rate of transcription of the beta 2-adrenergic receptor (beta 2AR) gene and the steady-state level of beta 2AR mRNA in DDT1MF-2 cells.	Epinephrine	26-37	beta-2 adrenergic receptor	Mesocricetus auratus	159-167
2472635-3	1989	Short-term (30 min) exposure to epinephrine (100 nM) stimulates the rate of beta 2AR gene transcription, resulting in a 3- to 4-fold increase in steady-state beta 2AR mRNA levels.	Epinephrine	32-43	beta-2 adrenergic receptor	Mesocricetus auratus	76-84
2472635-3	1989	Short-term (30 min) exposure to epinephrine (100 nM) stimulates the rate of beta 2AR gene transcription, resulting in a 3- to 4-fold increase in steady-state beta 2AR mRNA levels.	Epinephrine	32-43	beta-2 adrenergic receptor	Mesocricetus auratus	158-166
2572419-1	1989	The stimulant effects of adrenaline and noradrenaline on contractile force and adenylate cyclase, mediated through beta 1 and beta 2-adrenoceptors, are analysed in isolated atrial and ventricular myocardium of man.	Epinephrine	25-35	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	115-121
2475206-2	1989	Injections of substance P (35.6 pmol) into the superficial layers (lamina I-II) of subnucleus caudalis increased the adrenal secretion of epinephrine (+8.3 +/- 2.3 ng/min, P less than 0.01), arterial pressure (+11 +/- 5.3 mm Hg, P less than 0.01), and heart rate (+19.4 +/- 4.9 beats/min, P less than 0.01) by 1 min, and increased the plasma concentration of adrenocorticotropin (+26 +/- 10 pg/ml, P less than 0.01) by 3 min.	Epinephrine	138-149	tachykinin precursor 1	Homo sapiens	14-25
2475206-9	1989	Substance P-evoked changes in the adrenal secretion of epinephrine were not correlated with changes in adrenal venous blood flow, whereas bicuculline- and muscimol-evoked changes in adrenal secretion of catecholamines were positively correlated with changes in adrenal blood flow (P less than 0.01).	Epinephrine	55-66	tachykinin precursor 1	Homo sapiens	0-11
2506943-0	1989	[The action of an enzymatically stable Leu-enkephalin analog on the prostanoid content in the myocardium under stress- and adrenaline-induced damage].	Epinephrine	123-133	proenkephalin	Rattus norvegicus	43-53
2506943-1	1989	The protective action of enzymatically stable analogue of Leu-enkephalin (D-ala-2-leu5-arg6), injected intraperitoneally, in the course of stress- and epinephrine induced myocardial damage was demonstrated in animal (129 white rats) experiments.	Epinephrine	151-162	proenkephalin	Rattus norvegicus	62-72
2470585-3	1989	Addition of epinephrine (10(-6) M) together with propranolol (10(-6) M) to avoid interference with beta-adrenoreceptors did not affect basal glucose and palmitate oxidation, but suppressed the effects of VIP by more than 90%.	Epinephrine	12-23	vasoactive intestinal peptide	Rattus norvegicus	204-207
2470585-4	1989	The inhibition by VIP of pyruvate dehydrogenase and acetylcoenzyme-A carboxylase, the enzymes considered as the target sites for the neuropeptide, was also abolished by epinephrine.	Epinephrine	169-180	vasoactive intestinal peptide	Rattus norvegicus	18-21
2470585-5	1989	We assumed that epinephrine acted through the stimulation of alpha 2-adrenergic receptors, since 1) epinephrine suppressed VIP-induced accumulation of cAMP in the cells; and 2) the alpha 2-agonist clonidine (10(-6) M) reproduced epinephrine effects, whereas they were abolished by the alpha 2-antagonist yohimbine (10(-6) M).	Epinephrine	16-27	vasoactive intestinal peptide	Rattus norvegicus	123-126
2470585-5	1989	We assumed that epinephrine acted through the stimulation of alpha 2-adrenergic receptors, since 1) epinephrine suppressed VIP-induced accumulation of cAMP in the cells; and 2) the alpha 2-agonist clonidine (10(-6) M) reproduced epinephrine effects, whereas they were abolished by the alpha 2-antagonist yohimbine (10(-6) M).	Epinephrine	100-111	vasoactive intestinal peptide	Rattus norvegicus	123-126
2470585-5	1989	We assumed that epinephrine acted through the stimulation of alpha 2-adrenergic receptors, since 1) epinephrine suppressed VIP-induced accumulation of cAMP in the cells; and 2) the alpha 2-agonist clonidine (10(-6) M) reproduced epinephrine effects, whereas they were abolished by the alpha 2-antagonist yohimbine (10(-6) M).	Epinephrine	100-111	vasoactive intestinal peptide	Rattus norvegicus	123-126
2472358-6	1989	ANF profoundly decreases basal and stimulated (epinephrine, dopamine, isoproterenol, and forskolin) adenylate cyclase activity and cyclic adenosine monophosphate (AMP) levels.	Epinephrine	47-58	natriuretic peptides A	Oryctolagus cuniculus	0-3
2572419-1	1989	The stimulant effects of adrenaline and noradrenaline on contractile force and adenylate cyclase, mediated through beta 1 and beta 2-adrenoceptors, are analysed in isolated atrial and ventricular myocardium of man.	Epinephrine	25-35	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	126-132
2572419-3	1989	Usually, both adrenaline and noradrenaline stimulated adenylate cyclase predominantly through ventricular and atrial beta 2-adrenoceptors.	Epinephrine	14-24	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-123
2572419-6	1989	Adrenaline can also maximally enhance contractile force through atrial beta 2-adrenoceptors.	Epinephrine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	71-77
2572419-7	1989	In the ventricle, adrenaline increases force via beta 2-adrenoceptors by up to 60% of its maximal beta 1 response.	Epinephrine	18-28	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	49-55
2572419-7	1989	In the ventricle, adrenaline increases force via beta 2-adrenoceptors by up to 60% of its maximal beta 1 response.	Epinephrine	18-28	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	98-104
2572419-9	1989	Unexpectedly, in atria from patients treated with the beta 1-selective antagonist atenolol, contractile responses to adrenaline are markedly and selectively augmented through activation of beta 2-adrenoceptors.	Epinephrine	117-127	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	54-60
2572419-9	1989	Unexpectedly, in atria from patients treated with the beta 1-selective antagonist atenolol, contractile responses to adrenaline are markedly and selectively augmented through activation of beta 2-adrenoceptors.	Epinephrine	117-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	189-195
2572419-10	1989	In atria from atenolol-treated patients equi-inotropic concentrations of adrenaline and noradrenaline acting through beta 2 and beta 1-adrenoceptors, respectively, cause similar increases of cyclic AMP and of cyclic AMP-dependent protein kinase activity.	Epinephrine	73-83	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-148
2770052-12	1989	These results suggest that, at least in part, the potentiation of epinephrine-induced hyperglycemia by dihydropyridines, non-dihydropyridines and hydralazine is related to the inhibition of peripheral glucose utilization produced by insulin.	Epinephrine	66-77	insulin	Homo sapiens	233-240
2592754-2	1989	Both dose-response curves and time-courses of plasma glucose levels after single maximal doses showed that in vivo glycogenolytic responsiveness to glucagon and epinephrine was significantly higher in developing hypothyroid rats, whereas it remained unchanged after vasopressin and angiotensin II injections.	Epinephrine	161-172	arginine vasopressin	Rattus norvegicus	266-296
2539971-10	1989	Norepinephrine and epinephrine similarly inhibited POMC peptide secretion, but this effect was blocked by haloperidol, suggesting that it was mediated through a dopamine receptor.	Epinephrine	3-14	proopiomelanocortin	Canis lupus familiaris	51-55
2761788-2	1989	By means of a dual immunocytochemical labeling for phenylethanolamine-N-methyltransferase and glutamate decarboxylase, synaptic associations between adrenaline-synthesizing neurons and GABAergic terminals are demonstrated in the medial nucleus tractus solitarius of the rat.	Epinephrine	149-159	phenylethanolamine-N-methyltransferase	Rattus norvegicus	51-89
2761788-2	1989	By means of a dual immunocytochemical labeling for phenylethanolamine-N-methyltransferase and glutamate decarboxylase, synaptic associations between adrenaline-synthesizing neurons and GABAergic terminals are demonstrated in the medial nucleus tractus solitarius of the rat.	Epinephrine	149-159	glutamate-ammonia ligase	Rattus norvegicus	94-117
2571139-6	1989	Chemical sympathectomy following 6-hydroxydopamine caused a marked supersensitivity to the catecholamines and NPY but obliterated the NPY-induced potentiation of the pressor effect of adrenaline.	Epinephrine	184-194	neuropeptide Y	Rattus norvegicus	134-137
2472529-4	1989	Clenbuterol treatment produced desensitization of the beta 2-adrenoceptor-mediated effect and thus reduced the vasodilator response induced by isoproterenol and increased the vasoconstriction produced by epinephrine but not that caused by NE.	Epinephrine	204-215	adrenoceptor beta 2	Rattus norvegicus	54-73
2657547-3	1989	The total dose and the mg min-1 dose of bupivacaine was significantly less following epinephrine-morphine pretreatment than the dose required when only bupivacaine was used for pain relief.	Epinephrine	85-96	CD59 molecule (CD59 blood group)	Homo sapiens	26-31
2714445-3	1989	In astroglial cells treated with epinephrine (EN), the cellular NGF mRNA level increased prior to accumulation of NGF in the culture medium.	Epinephrine	33-44	nerve growth factor	Mus musculus	64-67
2714445-3	1989	In astroglial cells treated with epinephrine (EN), the cellular NGF mRNA level increased prior to accumulation of NGF in the culture medium.	Epinephrine	33-44	nerve growth factor	Mus musculus	114-117
2787179-0	1989	Selective inhibition of adrenaline-induced human platelet aggregation by the structurally related Paf antagonist Ro 19-3704.	Epinephrine	24-34	PCNA clamp associated factor	Homo sapiens	98-101
2787179-3	1989	In contrast, Ro 19-3704, a structurally related antagonist of Paf, inhibited concentration-dependently aggregation induced by adrenaline or by the simultaneous addition of submaximal concentrations of adrenaline and Paf.	Epinephrine	126-136	PCNA clamp associated factor	Homo sapiens	62-65
2787179-3	1989	In contrast, Ro 19-3704, a structurally related antagonist of Paf, inhibited concentration-dependently aggregation induced by adrenaline or by the simultaneous addition of submaximal concentrations of adrenaline and Paf.	Epinephrine	201-211	PCNA clamp associated factor	Homo sapiens	62-65
2787179-7	1989	CV-3988, an antagonist of Paf structurally similar to Ro 19-3704, also inhibited adrenaline-induced aggregation.	Epinephrine	81-91	PCNA clamp associated factor	Homo sapiens	26-29
2787179-14	1989	The Paf antagonist Ro 19-3704 interacts specifically with the alpha 2-adrenoceptor and may thus prevent the early steps involved in the mechanism of adrenaline-induced platelet activation.	Epinephrine	149-159	PCNA clamp associated factor	Homo sapiens	4-7
2754179-6	1989	The results of this study provide strong evidence at the level of mRNA expression that ProEnk A mRNA is expressed preferentially in the adrenaline synthesizing cells within the adrenal medulla.	Epinephrine	136-146	proenkephalin	Bos taurus	87-95
2528271-9	1989	Epinephrine did not affect spontaneous IL-2 receptor expression and it significantly inhibited PHA-induced IL-2 receptor expression and IL-2 generation at 30 min.	Epinephrine	0-11	interleukin 2	Homo sapiens	107-111
2528271-9	1989	Epinephrine did not affect spontaneous IL-2 receptor expression and it significantly inhibited PHA-induced IL-2 receptor expression and IL-2 generation at 30 min.	Epinephrine	0-11	interleukin 2	Homo sapiens	107-111
2716497-1	1989	Phenylethanolamine N-methyltransferase (PNMT), the enzyme which synthesizes the catecholamine epinephrine (adrenaline), may be regulated at many levels of expression.	Epinephrine	107-117	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
2648843-3	1989	Fetal plasma norepinephrine and epinephrine concentrations increased significantly during insulin infusion.	Epinephrine	16-27	LOC105613195	Ovis aries	90-97
2716497-1	1989	Phenylethanolamine N-methyltransferase (PNMT), the enzyme which synthesizes the catecholamine epinephrine (adrenaline), may be regulated at many levels of expression.	Epinephrine	107-117	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
2716497-3	1989	Furthermore, when the transcriptional rate is compared in strains of rat known to possess distinctive levels of epinephrine and PNMT enzyme, the rate of PNMT transcription in Fischer rats is greater than in Buffalo or Sprague-Dawley rats: relative ratios are 0.54:1.00:1.6 for Buffalo:Sprague-Dawley:Fischer adrenal glands.	Epinephrine	112-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	153-157
2537795-6	1989	The combination of ANF plus captopril produced a significant increase in plasma aldosterone (79 +/- 8 vs. 60 +/- 6 pmol/l, p less than 0.05), cortisol (406 +/- 52 vs. 265 +/- 29 nmol/l, p less than 0.01), adrenaline (119 +/- 21 vs. 76 +/- 10 pg/ml, p less than 0.05), and noradrenaline (319 +/- 49 vs. 215 +/- 38 pg/ml, p less than 0.05) compared with time-matched placebo data.	Epinephrine	205-215	natriuretic peptide A	Homo sapiens	19-22
2563674-13	1989	In addition, volume expansion during intravenous epinephrine (1.75 micrograms/kg/min) and angiotensin (1.0 micrograms/kg/min) doubled plasma IR-ANP levels.	Epinephrine	49-60	natriuretic peptide A	Rattus norvegicus	144-147
2538388-2	1989	In initial experiments, treatment with the centrally active phenylethanolomine N-methyltransferase (PNMT; the enzyme catalyzing methylation of norepinephrine to epinephrine) inhibitor SKF-64139 inhibited lordosis behavior induced by estradiol-17 beta benzoate plus progesterone.	Epinephrine	146-157	phenylethanolamine N-methyltransferase	Cavia porcellus	60-98
2538388-2	1989	In initial experiments, treatment with the centrally active phenylethanolomine N-methyltransferase (PNMT; the enzyme catalyzing methylation of norepinephrine to epinephrine) inhibitor SKF-64139 inhibited lordosis behavior induced by estradiol-17 beta benzoate plus progesterone.	Epinephrine	146-157	phenylethanolamine N-methyltransferase	Cavia porcellus	100-104
2784032-7	1989	CGRP increased plasma norepinephrine, epinephrine, and renin activity significantly at only the 2200-pmol dose.	Epinephrine	25-36	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2544037-1	1989	Exposure of platelets to phospholipase A2 selectively obliterates the aggregation response of human platelets to the action of epinephrine.	Epinephrine	127-138	phospholipase A2 group IB	Homo sapiens	25-41
2537033-0	1989	Tissue-type plasminogen activator release in response to epinephrine in perfused rat hindlegs.	Epinephrine	57-68	plasminogen activator, tissue type	Rattus norvegicus	0-33
2537033-8	1989	Epinephrine perfusion induced an increase only in the t-PA-like protein.	Epinephrine	0-11	plasminogen activator, tissue type	Rattus norvegicus	54-58
2537033-9	1989	These data indicate that the release of t-PA-like activity observed after epinephrine perfusion is mainly mediated by beta-receptors and is independent from its vasoactive action.	Epinephrine	74-85	plasminogen activator, tissue type	Rattus norvegicus	40-44
2492593-7	1989	Epinephrine, which causes neutrophilia solely by demargination, abrogated the TNF-induced neutropenia and actually resulted in a neutrophilia that was greater than the neutrophilia occurring in epinephrine alone-treated rats, demonstrating both that TNF had already caused release of marrow neutrophils at the time of peripheral neutropenia, and that the paradoxical neutropenia was due to the transient intravascular margination of neutrophils.	Epinephrine	0-11	tumor necrosis factor	Rattus norvegicus	78-81
2645780-16	1989	There was an additive, but small, hyperpolarizing effect of insulin and isoproterenol when administered in combination, suggesting that the greater magnitude of the insulin-induced hyperpolarization observed in situ in normal rats may be due to an additive effect of injected insulin and endogenous release of epinephrine.	Epinephrine	310-321	insulin	Homo sapiens	60-67
2645780-16	1989	There was an additive, but small, hyperpolarizing effect of insulin and isoproterenol when administered in combination, suggesting that the greater magnitude of the insulin-induced hyperpolarization observed in situ in normal rats may be due to an additive effect of injected insulin and endogenous release of epinephrine.	Epinephrine	310-321	insulin	Homo sapiens	165-172
2645780-16	1989	There was an additive, but small, hyperpolarizing effect of insulin and isoproterenol when administered in combination, suggesting that the greater magnitude of the insulin-induced hyperpolarization observed in situ in normal rats may be due to an additive effect of injected insulin and endogenous release of epinephrine.	Epinephrine	310-321	insulin	Homo sapiens	165-172
2565729-0	1989	Importance of beta 2-adrenoceptor stimulation in the suppression of intradermal antigen challenge by adrenaline.	Epinephrine	101-111	adrenoceptor beta 2	Homo sapiens	14-33
2550130-0	1989	Effects of chronic treatment with adrenaline or propranolol on platelet function and c-AMP levels in the rat.	Epinephrine	34-44	cathelicidin antimicrobial peptide	Rattus norvegicus	85-90
2550130-6	1989	For animals treated with adrenaline, in accordance with the results of the aggregation experiments, the levels of c-AMP found in platelet rich plasma were reduced, both basally (by 33%) and after stimulation of platelet adenylate cyclase with prostaglandin E1 (by 39%).	Epinephrine	25-35	cathelicidin antimicrobial peptide	Rattus norvegicus	114-119
2550130-9	1989	Although the in vitro addition of adrenaline to platelet rich plasma causes a beta-adrenoceptor mediated inhibition of platelet aggregation in the rat, the simulation seen after chronic adrenaline exposure in vivo, which is associated with decreases in both basal and stimulated c-AMP levels, suggests a functional preponderance of alpha-adrenoceptors over beta-adrenoceptors on the rat platelets.	Epinephrine	34-44	cathelicidin antimicrobial peptide	Rattus norvegicus	279-284
2550130-9	1989	Although the in vitro addition of adrenaline to platelet rich plasma causes a beta-adrenoceptor mediated inhibition of platelet aggregation in the rat, the simulation seen after chronic adrenaline exposure in vivo, which is associated with decreases in both basal and stimulated c-AMP levels, suggests a functional preponderance of alpha-adrenoceptors over beta-adrenoceptors on the rat platelets.	Epinephrine	186-196	cathelicidin antimicrobial peptide	Rattus norvegicus	279-284
2537324-8	1989	When macrophages were exposed to 10(-5) M epinephrine and 10(-8) M met-enkephalin, cell morphology and spreading were indistinguishable from that due to 10(-5) M epinephrine alone.	Epinephrine	162-173	proopiomelanocortin	Homo sapiens	67-81
2537324-9	1989	The epinephrine dose-response curve in the presence of 10(-8) M met-enkephalin was similar to that of epinephrine alone.	Epinephrine	4-15	proopiomelanocortin	Homo sapiens	64-78
2492593-7	1989	Epinephrine, which causes neutrophilia solely by demargination, abrogated the TNF-induced neutropenia and actually resulted in a neutrophilia that was greater than the neutrophilia occurring in epinephrine alone-treated rats, demonstrating both that TNF had already caused release of marrow neutrophils at the time of peripheral neutropenia, and that the paradoxical neutropenia was due to the transient intravascular margination of neutrophils.	Epinephrine	0-11	tumor necrosis factor	Rattus norvegicus	250-253
2492593-7	1989	Epinephrine, which causes neutrophilia solely by demargination, abrogated the TNF-induced neutropenia and actually resulted in a neutrophilia that was greater than the neutrophilia occurring in epinephrine alone-treated rats, demonstrating both that TNF had already caused release of marrow neutrophils at the time of peripheral neutropenia, and that the paradoxical neutropenia was due to the transient intravascular margination of neutrophils.	Epinephrine	194-205	tumor necrosis factor	Rattus norvegicus	78-81
2492593-8	1989	The known property of epinephrine to cause neutrophilia exclusively by demargination was proved by examination of the bone marrow of epinephrine-treated rats in whom no decrease in marrow neutrophils was observed (in contrast to TNF- and IL-1-treated rats in whom neutrophilia is accompanied by a depletion of marrow neutrophils).	Epinephrine	22-33	tumor necrosis factor	Rattus norvegicus	229-232
2741653-5	1989	The 5-day-stored platelets stimulated with the combination of ADP and epinephrine scarcely bound fibrinogen, but did bind NNKY1-32.	Epinephrine	70-81	fibrinogen beta chain	Homo sapiens	97-107
2918403-7	1989	In isolated kidney tubules the abundance of the mRNA is increased after incubation with glucocorticoids, dibutyryl cAMP or hormones acting via changes in the concentration of cAMP (parathyroid hormone, epinephrine).	Epinephrine	202-213	cathelicidin-2	Gallus gallus	115-119
2918403-7	1989	In isolated kidney tubules the abundance of the mRNA is increased after incubation with glucocorticoids, dibutyryl cAMP or hormones acting via changes in the concentration of cAMP (parathyroid hormone, epinephrine).	Epinephrine	202-213	cathelicidin-2	Gallus gallus	175-179
2741653-6	1989	On stimulation with collagen and epinephrine, a large amount of fibrinogen bound to the surface membrane of 3- and 5-day-stored platelets, and the binding of NNKY1-32 also increased, reaching the same level seen in stored platelets stimulated with ADP and epinephrine.	Epinephrine	33-44	fibrinogen beta chain	Homo sapiens	64-74
2741653-6	1989	On stimulation with collagen and epinephrine, a large amount of fibrinogen bound to the surface membrane of 3- and 5-day-stored platelets, and the binding of NNKY1-32 also increased, reaching the same level seen in stored platelets stimulated with ADP and epinephrine.	Epinephrine	256-267	fibrinogen beta chain	Homo sapiens	64-74
2492669-2	1989	Insulin-like effects were measured by the ability of PGF, insulin, or hGH to stimulate oxidation of [U-14C]glucose to 14CO2, to stimulate lipogenesis, and to inhibit epinephrine-induced lipolysis.	Epinephrine	166-177	insulin	Homo sapiens	58-65
2492669-2	1989	Insulin-like effects were measured by the ability of PGF, insulin, or hGH to stimulate oxidation of [U-14C]glucose to 14CO2, to stimulate lipogenesis, and to inhibit epinephrine-induced lipolysis.	Epinephrine	166-177	insulin	Homo sapiens	0-7
2492669-2	1989	Insulin-like effects were measured by the ability of PGF, insulin, or hGH to stimulate oxidation of [U-14C]glucose to 14CO2, to stimulate lipogenesis, and to inhibit epinephrine-induced lipolysis.	Epinephrine	166-177	placental growth factor	Rattus norvegicus	53-56
2492669-5	1989	Insulin, hGH, and PGF inhibited epinephrine-induced lipolysis of preincubated (3 hr) adipose tissue.	Epinephrine	32-43	insulin	Homo sapiens	0-7
2492669-5	1989	Insulin, hGH, and PGF inhibited epinephrine-induced lipolysis of preincubated (3 hr) adipose tissue.	Epinephrine	32-43	placental growth factor	Rattus norvegicus	18-21
2521270-5	1989	The plasma ANF level was directly correlated with the plasma norepinephrine concentration (r = 0.83, p less than 0.01), plasma epinephrine concentration (r = 0.46, p less than 0.01), plasma renin activity (r = 0.50, p less than 0.01), plasma angiotensin II concentration (r = 0.79, p less than 0.01) and plasma vasopressin concentrations (r = 0.65, p less than 0.01).	Epinephrine	64-75	natriuretic peptide A	Homo sapiens	11-14
2924106-2	1989	The light and electron microscopic localization of a polyclonal antiserum directed against the adrenaline synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT) was used to determine the identity and targets of the adrenergic afferents to the LC of the rat brain.	Epinephrine	95-105	phenylethanolamine-N-methyltransferase	Rattus norvegicus	127-165
2919858-4	1989	Reported symptomatology at sea level was predictive of 24 h. excretion rates of adrenaline and 17-hydroxycorticosteroids at high altitude.	Epinephrine	80-90	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	27-30
2924106-2	1989	The light and electron microscopic localization of a polyclonal antiserum directed against the adrenaline synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT) was used to determine the identity and targets of the adrenergic afferents to the LC of the rat brain.	Epinephrine	95-105	phenylethanolamine-N-methyltransferase	Rattus norvegicus	167-171
2924106-14	1989	The detection of PNMT-LI in cells that are not known to synthesize adrenaline is surprising and suggests either a functional diversity for PNMT or amino acid sequence homologies with related enzymes which are enriched in the LC.	Epinephrine	67-77	phenylethanolamine-N-methyltransferase	Rattus norvegicus	17-21
2910096-4	1989	Plasma NPY correlated better with plasma norepinephrine than with epinephrine, indicating its origin from sympathetic nerve terminals.	Epinephrine	44-55	neuropeptide Y	Homo sapiens	7-10
2669881-15	1989	The high concentrations of counterregulatory hormones, cortisol, epinephrine, and glucagon will minimize glucose utilization by insulin-sensitive tissues, despite high concentrations of both glucose and insulin, but these hormones are not able to prevent suppression of ketone body synthesis in the liver.	Epinephrine	65-76	insulin	Homo sapiens	128-135
2535942-13	1989	We conclude that epinephrine itself can induce fibrinogen receptor exposure, fibrinogen binding, and aggregation.	Epinephrine	17-28	fibrinogen beta chain	Homo sapiens	47-57
2549387-4	1989	The inhibition of bradykinin-stimulated AA release by sphingosine (20.2 +/- 6.1%) was substantially less than the inhibition observed for tetradecanoyl phorbol-13-acetate- (67.2 +/- 5.5%) and epinephrine-stimulated release (50.2 +/- 9.2%).	Epinephrine	192-203	kininogen 1	Canis lupus familiaris	18-28
2535942-13	1989	We conclude that epinephrine itself can induce fibrinogen receptor exposure, fibrinogen binding, and aggregation.	Epinephrine	17-28	fibrinogen beta chain	Homo sapiens	77-87
2909302-2	1989	Neuropeptide Y (NPY) coexists with adrenaline and noradrenaline in the rat brain, and interactions among these substances have been studied.	Epinephrine	35-45	neuropeptide Y	Rattus norvegicus	0-14
2743605-1	1989	Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system.	Epinephrine	38-48	neuropeptide Y	Homo sapiens	0-14
2743605-1	1989	Neuropeptide Y (NPY) coexists with noradrenaline in postganglionic sympathetic neurons and with noradrenaline and adrenaline in the central nervous system.	Epinephrine	38-48	neuropeptide Y	Homo sapiens	16-19
2572385-6	1989	Increases in the peripheral levels of PRL in these animals were associated with decreases in adrenal medulla weight and increases in adrenal medulla contents of norepinephrine, epinephrine and vanilmandelic acid, the main degradative metabolite of CA, while adrenal medulla contents of the O-methylated derivatives of CA, normetanephrine and metanephrine, were unaltered.	Epinephrine	164-175	prolactin	Mesocricetus auratus	38-41
2565196-2	1989	Epinephrine, norepinephrine, isoproterenol, dopamine, and the specific alpha 2-adrenergic agonists clonidine and p-aminoclonidine exhibit dose-dependent inhibition of VIP-stimulated cyclic AMP production.	Epinephrine	0-11	VIP peptides	Oryctolagus cuniculus	167-170
2565196-4	1989	Inhibition of VIP-stimulated cyclic AMP production by clonidine, epinephrine, isoproterenol, and dopamine is blocked by yohimbine but not by prazosin.	Epinephrine	65-76	VIP peptides	Oryctolagus cuniculus	14-17
2576535-4	1989	In the light of action of epinephrine, an inhibitor of insulin secretion, possible mechanisms responsible for disturbed hormone release in the presence of proteolytic enzymes are discussed.	Epinephrine	26-37	insulin	Homo sapiens	55-62
2547602-2	1989	Data presented in this manuscript demonstrate an insulin-like effect of PMA, a tumor promoting agent that mimics the action of diacylglycerol, in isolated adipocytes on; (a) glucose oxidation using uniformly labelled, C-1-labelled and C-6-labelled glucose, (b) epinephrine-induced lipolysis and (c) low Km cAMP phosphodiesterase activity.	Epinephrine	261-272	insulin	Homo sapiens	49-56
2565245-0	1989	Evidence for the occurrence of an enkephalin-like peptide in adrenaline and noradrenaline neurons of the rat medulla oblongata.	Epinephrine	61-71	proenkephalin	Rattus norvegicus	34-44
2575545-12	1989	Selenite, which in vivo has the same effect as epinephrine, enhances ODC activity in culture.	Epinephrine	47-58	ornithine decarboxylase	Gallus gallus	69-72
2558980-4	1989	The autooxidation of epinephrine, but not the reduction of ferricytochrome-C, was found to be sensitive to SOD.	Epinephrine	21-32	superoxide dismutase 1	Homo sapiens	107-110
2693310-1	1989	In insulin-dependent (type 1) diabetic subjects (n = 7) with intact hormone response to hypoglycaemia, oxytocin infusion (0.2 mU/min over 60 min) produced significant rises in basal plasma glucagon and adrenaline levels, while it reduced basal plasma cortisol levels.	Epinephrine	202-212	oxytocin/neurophysin I prepropeptide	Homo sapiens	103-111
2693310-2	1989	During insulin-induced hypoglycaemia, oxytocin potentiated the increases in plasma glucagon and adrenaline, while an inhibitory effect on plasma cortisol levels was still present.	Epinephrine	96-106	oxytocin/neurophysin I prepropeptide	Homo sapiens	38-46
2693310-5	1989	In conclusion, in insulin-dependent (type 1) diabetic patients, oxytocin delivery enhances plasma glucagon and adrenaline levels in basal conditions and during insulin-induced hypoglycaemia.	Epinephrine	111-121	oxytocin/neurophysin I prepropeptide	Homo sapiens	64-72
2477332-5	1989	In both types of effector cells, adrenaline significantly suppressed NKCC at a final concentration of 10(-11) M. Pretreatment of LD effector cells with IFN-alpha reduced the NKCC suppression by subsequent adrenaline treatment.	Epinephrine	33-43	interferon alpha 1	Homo sapiens	152-161
2477332-6	1989	Pretreatment with recombinant IL-2 virtually abolished the response to adrenaline.	Epinephrine	71-81	interleukin 2	Homo sapiens	30-34
2468939-3	1989	in 10 s; 10-50 min postmedication] similarly reduced the submaximal arteriolar vasoconstriction induced by topically applied epinephrine (maximal concentrations 1 x 10(-7) and 1 x 10(-6) M), illustrating their inhibitory action against stimulated Ca2+ influx into vascular smooth muscle cells at the doses examined.	Epinephrine	125-136	carbonic anhydrase 2	Rattus norvegicus	247-250
2545988-3	1989	Using cultured rat adrenal capsules, we found that 10(-7) M epinephrine and 10(-7) M isoproterenol enhanced 10(-7) M AII-stimulated aldosterone production.	Epinephrine	60-71	angiotensinogen	Rattus norvegicus	117-120
2473320-1	1989	Addition of endothelin-1 (ET-1) to primary cultures of bovine adrenal chromaffin cells causes a significant enhancement of norepinephrine and epinephrine efflux, with an EC50 of about 1 nM.	Epinephrine	126-137	endothelin 1	Bos taurus	12-24
2473320-1	1989	Addition of endothelin-1 (ET-1) to primary cultures of bovine adrenal chromaffin cells causes a significant enhancement of norepinephrine and epinephrine efflux, with an EC50 of about 1 nM.	Epinephrine	126-137	endothelin 1	Bos taurus	26-30
2473320-3	1989	The amounts of noradrenaline and adrenaline released by ET-1 was smaller than the release elicited by maximally effective concentrations of bradykinin or prostaglandin E2.	Epinephrine	18-28	endothelin 1	Bos taurus	56-60
2577008-6	1989	Displacement binding analyses revealed a potency series of (-) isoproterenol greater than (-) epinephrine equal to (-) norepinephrine, suggesting a predominance of the beta 1 adrenoceptor subtype.	Epinephrine	90-105	adrenoceptor beta 1	Rattus norvegicus	168-187
2545988-4	1989	Propranolol (10(-7) M) completely inhibited the ability of epinephrine to augment the stimulatory actions of AII.	Epinephrine	59-70	angiotensinogen	Rattus norvegicus	109-112
2502780-2	1989	Adenosine deaminase did not influence the control coronary flow, but significantly reduced autoregulation, hypoxic vasodilation, reactive hyperemia and functional adrenaline-induced hyperemia.	Epinephrine	163-173	adenosine deaminase	Rattus norvegicus	0-19
2542808-7	1989	(-)-Adrenaline and dopamine appeared to be non-selective for beta 1 and beta 2.	Epinephrine	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	61-78
2502780-5	1989	Adenosine deaminase completely abolished reactive hyperemia during control perfusion but only delayed it under adrenaline perfusion.	Epinephrine	111-121	adenosine deaminase	Rattus norvegicus	0-19
2749007-6	1989	Gastrin release increased by a maximum of 85 +/- 38% (at epinephrine 75 ng.kg-1.min-1).	Epinephrine	57-68	gastrin	Homo sapiens	0-7
2563164-2	1989	These cell groups (C1 and C2) were thought to supply the epinephrine innervation in the rest of the central nervous system.	Epinephrine	57-68	complement C2	Rattus norvegicus	19-28
3067127-3	1988	injection of chicken GnRH II or salmon GnRH increased plasma noradrenaline and adrenaline concentrations, at doses that did not significantly affect arterial blood pressure or heart rate.	Epinephrine	64-74	mitochondrial ribosomal protein S26	Gallus gallus	21-28
3067127-4	1988	Chicken GnRH II was 10 times more potent than salmon GnRH for increasing plasma adrenaline, while the two neuropeptides were equally effective in raising noradrenaline concentration.	Epinephrine	80-90	mitochondrial ribosomal protein S26	Gallus gallus	8-15
3253235-5	1988	During cross-country skiing, the average noradrenaline elimination (1166 pmol.min-1) was about 150% higher and the average adrenaline elimination (243 pmol.min-1) about 30% lower than during ski-flying.	Epinephrine	44-54	SKI proto-oncogene	Homo sapiens	21-24
3202191-8	1988	Epinephrine potentiates the action of all types of aggregating agents on aggregation, secretion, intracellular Ca2+ levels, membrane fluidity, fibrinogen binding, or protein phosphorylation.	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	143-153
2850915-7	1988	In congenital HGH and ACTH deficiency, the low basal plasma levels of noradrenaline (0.12 ng/ml) and adrenaline (0.01 ng/ml) remained unchanged in response to hypoglycaemia.	Epinephrine	73-83	proopiomelanocortin	Homo sapiens	22-26
3253235-6	1988	The noradrenaline-adrenaline ratio was about 4.8 in cross-country skiing and 1.3-1.5 in ski-flying.	Epinephrine	7-17	SKI proto-oncogene	Homo sapiens	66-69
2853270-5	1988	When epinephrine is infused at different rates into exercising rats, liver cAMP appears to be unrelated to plasma epinephrine.	Epinephrine	5-16	cathelicidin antimicrobial peptide	Rattus norvegicus	75-79
3241254-2	1988	Therefore, man"s endogenous beta 2-adrenoceptor agonist adrenaline has been implicated in the pathogenesis of hypertension.	Epinephrine	56-66	adrenoceptor beta 2	Homo sapiens	28-47
3241254-7	1988	The pressor effect of adrenaline could not be explained by a central mechanism or by activation of the renin-angiotensin system.	Epinephrine	22-32	renin	Homo sapiens	103-108
3199796-11	1988	Pretreatment of cells with 100 microM 1,3-bis(2-chloroethyl)-1-nitrosourea which inhibits glutathione reductase, before the addition of plasma, increased the sensitivity of these cells to the epinephrine plasma, as measured by fall in intracellular ATP.	Epinephrine	192-203	glutathione-disulfide reductase	Rattus norvegicus	90-111
3183958-1	1988	SDZ 64-412 is a trimethoxyphenylethylphenyl imidazo[2,1-a] isoquinoline molecule that displays marked in vitro inhibition of platelet activating factor (PAF)-induced human platelet aggregation (IC50 = 60 nM) but is without inhibition (at 100 microM) of epinephrine-, ADP- or collagen-induced aggregation.	Epinephrine	253-264	PCNA clamp associated factor	Homo sapiens	153-156
3239759-6	1988	SOD measurements are carried out using a modification of established techniques whereby the inhibition of oxidation of epinephrine by SOD is assayed fluorometrically.	Epinephrine	119-130	superoxide dismutase 1	Homo sapiens	0-3
3239759-6	1988	SOD measurements are carried out using a modification of established techniques whereby the inhibition of oxidation of epinephrine by SOD is assayed fluorometrically.	Epinephrine	119-130	superoxide dismutase 1	Homo sapiens	134-137
2844513-9	1988	The approximately equipotent effect of epinephrine and norepinephrine indicated that the beta-adrenergic effect on cAMP production is principally mediated via the beta 1-adrenergic receptor.	Epinephrine	39-50	adrenoceptor beta 1	Bos taurus	163-189
3249631-0	1988	[Changes in the activity of glucose-6-phosphate dehydrogenase in the myocardium of rats with high and low resistance to hypoxia after administration of a cardiotoxic dose of epinephrine].	Epinephrine	174-185	glucose-6-phosphate dehydrogenase	Rattus norvegicus	28-61
3059027-3	1988	We report herein the measurement of GFR with the use of a radiocontrast agent (diatrizoate meglumine) injected subcutaneously with a small amount of epinephrine (0.05 ml of 1:1000).	Epinephrine	149-160	Rap guanine nucleotide exchange factor 5	Homo sapiens	36-39
3205608-7	1988	Peak PP levels were also significantly correlated with the peak epinephrine levels (r = 0.6, p less than 0.001) but not with norepinephrine.	Epinephrine	64-75	pancreatic polypeptide	Homo sapiens	5-7
3205608-8	1988	Our findings suggest that 1) GH deficiency disorders are not associated with impaired vagal cholinergic response to hypoglycemia; 2) in children the magnitude of PP response is inversely related to the degree of hypoglycemia; and 3) the peripheral hormonal manifestation of autonomic nervous system responses to hypoglycemia as measured by PP and epinephrine levels are closely correlated.	Epinephrine	347-358	pancreatic polypeptide	Homo sapiens	162-164
3239955-3	1988	The epinephrine neurons have a specific enzymatic marker, phenylethanolamine N-methyltransferase (PNMT), which allows them to be identified chemically and immunohistochemically.	Epinephrine	4-15	phenylethanolamine N-methyltransferase	Homo sapiens	58-96
3049587-6	1988	Insulin or epinephrine caused 40% inhibition of this induction of SDH mRNA.	Epinephrine	11-22	serine dehydratase	Rattus norvegicus	66-69
3049587-8	1988	In vitro transcription experiments using nuclei isolated from cultured hepatocytes showed that transcription of the SDH gene was not affected by either dexamethasone or glucagon alone, but markedly enhanced by both hormones together, and that this enhancement was inhibited by insulin or epinephrine.	Epinephrine	288-299	serine dehydratase	Rattus norvegicus	116-119
3049587-9	1988	These results indicate that the inhibition of SDH induction by epinephrine or insulin was due to effects of these hormones on the transcriptional rate of the SDH gene.	Epinephrine	63-74	serine dehydratase	Rattus norvegicus	46-49
3049587-9	1988	These results indicate that the inhibition of SDH induction by epinephrine or insulin was due to effects of these hormones on the transcriptional rate of the SDH gene.	Epinephrine	63-74	serine dehydratase	Rattus norvegicus	158-161
3239955-3	1988	The epinephrine neurons have a specific enzymatic marker, phenylethanolamine N-methyltransferase (PNMT), which allows them to be identified chemically and immunohistochemically.	Epinephrine	4-15	phenylethanolamine N-methyltransferase	Homo sapiens	98-102
3058507-4	1988	2 patients with MRx even exhibited a decrement of plt count after epinephrine, similar to that observed in all 5 healthy asplenic subjects tested.	Epinephrine	66-77	discs large MAGUK scaffold protein 3	Homo sapiens	16-19
3197373-2	1988	On two separate occasions, at least 1 week apart, seven young healthy male subjects received intravenous infusions of either adrenaline [0.27 nmol (50 ng) min-1 kg-1] or saline (154 mmol/l NaCl), plus ascorbic acid (5.68 mmol/l), over 30 min.	Epinephrine	125-135	CD59 molecule (CD59 blood group)	Homo sapiens	155-165
3058507-5	1988	Our results suggest that mRx and conditioning for BMT including total body irradiation (TBI) does not alter the splenic function, but that the combination of MRx and conditioning regimen including TBI may cause functional hyposplenism, sensitively revealed by reduction in plt count after epinephrine stimulation.	Epinephrine	289-300	discs large MAGUK scaffold protein 3	Homo sapiens	158-161
3198247-3	1988	Adrenaline is also able to increase the AGP level.	Epinephrine	0-10	orosomucoid 1	Rattus norvegicus	40-43
3421335-2	1988	GRP injected into the third cerebral ventricle significantly (P less than 0.01) increased plasma epinephrine but not norepinephrine concentrations.	Epinephrine	97-108	gastrin releasing peptide	Canis lupus familiaris	0-3
3421335-6	1988	An intravenous infusion of epinephrine that produced similar plasma concentrations of epinephrine that were observed after cerebroventricular injection of GRP mimicked the increase in left gastric artery flow induced by GRP.	Epinephrine	86-97	gastrin releasing peptide	Canis lupus familiaris	155-158
3421335-6	1988	An intravenous infusion of epinephrine that produced similar plasma concentrations of epinephrine that were observed after cerebroventricular injection of GRP mimicked the increase in left gastric artery flow induced by GRP.	Epinephrine	86-97	gastrin releasing peptide	Canis lupus familiaris	220-223
3421335-7	1988	It is concluded that 1) GRP acts within the central nervous system to activate the sympathoadrenal axis, 2) GRP inhibits gastric emptying of a liquid meal by a vagally dependent mechanism and enhances left gastric artery flow by the release of epinephrine from the adrenal medulla, and 3) the pathway(s) that mediate the GRP-induced inhibition of gastric acid in the dog remain unknown.	Epinephrine	244-255	gastrin releasing peptide	Canis lupus familiaris	24-27
3421335-7	1988	It is concluded that 1) GRP acts within the central nervous system to activate the sympathoadrenal axis, 2) GRP inhibits gastric emptying of a liquid meal by a vagally dependent mechanism and enhances left gastric artery flow by the release of epinephrine from the adrenal medulla, and 3) the pathway(s) that mediate the GRP-induced inhibition of gastric acid in the dog remain unknown.	Epinephrine	244-255	gastrin releasing peptide	Canis lupus familiaris	108-111
3421335-7	1988	It is concluded that 1) GRP acts within the central nervous system to activate the sympathoadrenal axis, 2) GRP inhibits gastric emptying of a liquid meal by a vagally dependent mechanism and enhances left gastric artery flow by the release of epinephrine from the adrenal medulla, and 3) the pathway(s) that mediate the GRP-induced inhibition of gastric acid in the dog remain unknown.	Epinephrine	244-255	gastrin releasing peptide	Canis lupus familiaris	108-111
3421335-5	1988	However, ganglionic blockade or vagotomy abolished the GRP-induced inhibition of gastric emptying, and ganglionic blockade or adrenalectomy abolished the GRP-induced increases in left gastric artery flow and plasma epinephrine concentrations.	Epinephrine	215-226	gastrin releasing peptide	Canis lupus familiaris	154-157
3421335-6	1988	An intravenous infusion of epinephrine that produced similar plasma concentrations of epinephrine that were observed after cerebroventricular injection of GRP mimicked the increase in left gastric artery flow induced by GRP.	Epinephrine	27-38	gastrin releasing peptide	Canis lupus familiaris	155-158
3421335-6	1988	An intravenous infusion of epinephrine that produced similar plasma concentrations of epinephrine that were observed after cerebroventricular injection of GRP mimicked the increase in left gastric artery flow induced by GRP.	Epinephrine	27-38	gastrin releasing peptide	Canis lupus familiaris	220-223
2851354-0	1988	Contribution of beta 1- and beta 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol.	Epinephrine	100-110	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	16-22
2851354-17	1988	beta 2-Adrenoceptors appear to be capable of mediating maximal positive inotropic effects of (-)-adrenaline in atrium.	Epinephrine	93-107	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
2851354-18	1988	In contrast, ventricular beta 2-adrenoceptors mediated only submaximal effects of (-)-adrenaline.	Epinephrine	82-96	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	25-31
2851354-0	1988	Contribution of beta 1- and beta 2-adrenoceptors of human atrium and ventricle to the effects of noradrenaline and adrenaline as assessed with (-)-atenolol.	Epinephrine	100-110	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	28-34
3141200-1	1988	Intravenous injection of the synthetic TRH analog, MK-771, to anesthetised cats raised the blood pressure by a central mechanism, i.e. by activating the outflow of sympathetic stimuli from the CNS to the periphery and raising the plasma concentration of adrenaline and noradrenaline.	Epinephrine	254-264	thyrotropin releasing hormone	Felis catus	39-42
3416074-0	1988	DDAVP and epinephrine-induced changes in the localization of von Willebrand factor antigen in endothelial cells of human oral mucosa.	Epinephrine	10-21	von Willebrand factor	Homo sapiens	61-82
3416074-2	1988	After administration of epinephrine or 1-deamino-8-D-arginine vasopressin (DDAVP), the localization of vWF:Ag was shown to have changed to the basement membrane and the surrounding interstitium.	Epinephrine	24-35	von Willebrand factor	Homo sapiens	103-106
3416074-3	1988	This change of vWF:Ag localization induced by epinephrine and DDAVP may play a role in the adhesion of platelets to subendothelium following endothelial injury during surgery and may be an unknown hemostatic effect of these drugs.	Epinephrine	46-57	von Willebrand factor	Homo sapiens	15-18
2843189-2	1988	Epinephrine, acting as an alpha 2-adrenergic agonist, inhibits the PTH-induced synthesis of cAMP by a pertussis toxin-sensitive mechanism and blunts the inhibition of phosphate transport by PTH.	Epinephrine	0-11	parathyroid hormone	Homo sapiens	67-70
2843189-2	1988	Epinephrine, acting as an alpha 2-adrenergic agonist, inhibits the PTH-induced synthesis of cAMP by a pertussis toxin-sensitive mechanism and blunts the inhibition of phosphate transport by PTH.	Epinephrine	0-11	parathyroid hormone	Homo sapiens	190-193
3408741-1	1988	Secretion of human platelet dense granule contents in response to epinephrine and other weak agonists requires the prior liberation of membrane-esterified arachidonic acid by a phospholipase A2 enzyme species whose activity is regulated by Na+/H+ exchange (e.g., Sweatt et al.	Epinephrine	66-77	phospholipase A2 group IB	Homo sapiens	177-193
3408741-15	1988	The interdependent regulation of phospholipase A2 activity by changes in pH and Ca2+ suggests that phospholipase A2 could serve to integrate changes in intracellular pH and available Ca2+ that occur subsequent to activation of human platelets by epinephrine and other weak agonists.	Epinephrine	246-257	phospholipase A2 group IB	Homo sapiens	33-49
3408741-15	1988	The interdependent regulation of phospholipase A2 activity by changes in pH and Ca2+ suggests that phospholipase A2 could serve to integrate changes in intracellular pH and available Ca2+ that occur subsequent to activation of human platelets by epinephrine and other weak agonists.	Epinephrine	246-257	phospholipase A2 group IB	Homo sapiens	99-115
3396263-7	1988	In addition the normal vasodilating response to an increase of circulating epinephrine to levels occurring during daily life stress seems impaired even with the low dose of this beta 1-selective beta-blocker.	Epinephrine	75-86	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	178-184
3401114-0	1988	Lactic acidosis and insulin resistance associated with epinephrine in a patient with noninsulin-dependent diabetes mellitus.	Epinephrine	55-66	insulin	Homo sapiens	20-27
2906021-0	1988	Transient insulin resistance following infusion of adrenaline in type 1 (insulin-dependent) diabetes mellitus.	Epinephrine	51-61	insulin	Homo sapiens	10-17
2906021-1	1988	Insulin resistance was assessed after an intravenous infusion of adrenaline (50 ng.kg-1.min-1) or saline (control study) given between 08.00 and 08.30 hours in nine patients with Type 1 (insulin-dependent) diabetes mellitus.	Epinephrine	65-75	insulin	Homo sapiens	0-7
2906021-6	1988	In comparison with the control study the infusion of adrenaline decreased the need for intravenous glucose significantly over the initial 2 h. Furthermore, during the somatostatin-insulin-glucose infusion test the blood glucose rose significantly (p less than 0.05) over the initial 2 h; thereafter no significant differences between the two studies were seen.	Epinephrine	53-63	insulin	Homo sapiens	180-187
3173685-4	1988	These results indicate heterogeneities in the responses of the adrenaline-neuropeptide Y cell groups to the aging process.	Epinephrine	63-73	pyroglutamylated RFamide peptide	Rattus norvegicus	74-86
2535942-0	1989	Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists.	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	29-39
2535942-0	1989	Epinephrine induces platelet fibrinogen receptor expression, fibrinogen binding, and aggregation in whole blood in the absence of other excitatory agonists.	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	61-71
2535942-5	1989	In blood anticoagulated with citrate and in the presence of a cyclooxygenase inhibitor, epinephrine (0.1 to 100 mumol/L) caused significant FITC-PAC1 binding (P less than .001) that was maximal at 10 mumol/L epinephrine.	Epinephrine	88-99	ADCYAP receptor type I	Homo sapiens	145-149
2535942-8	1989	Despite this, FITC-PAC1 binding was still significant at epinephrine greater than or equal to 1 mumol/L (P less than .05).	Epinephrine	57-68	ADCYAP receptor type I	Homo sapiens	19-23
3140409-10	1988	There was a positive correlation between the rate of increase in plasma t-PA antigen and the rate of increase in plasma epinephrine after smoking.	Epinephrine	120-131	plasminogen activator, tissue type	Homo sapiens	72-76
2845924-5	1988	The thrombin-induced hydrolysis of inositol phospholipids by phospholipase C, which was measured as the formation of [32P]PA, was potentiated by adrenaline, as was the increase in the levels of [32P]PIP2 and [32P]PIP.	Epinephrine	145-155	coagulation factor II, thrombin	Homo sapiens	4-12
2845924-6	1988	The presence of adrenaline caused a shift to the left for the thrombin-induced changes in the phosphoinositide metabolism, without affecting the maximal levels of 32P-labelled compounds obtained.	Epinephrine	16-26	coagulation factor II, thrombin	Homo sapiens	62-70
2845924-0	1988	Synergism between thrombin and adrenaline (epinephrine) in human platelets.	Epinephrine	43-54	coagulation factor II, thrombin	Homo sapiens	18-26
2845924-7	1988	A similar shift by adrenaline in the dose-response relationship was previously demonstrated for thrombin-induced aggregation and dense-granule secretion.	Epinephrine	19-29	coagulation factor II, thrombin	Homo sapiens	96-104
2845924-4	1988	Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml).	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	172-180
2845924-8	1988	Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion).	Epinephrine	64-74	coagulation factor II, thrombin	Homo sapiens	44-52
2845924-4	1988	Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml).	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	222-230
2845924-8	1988	Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion).	Epinephrine	64-74	coagulation factor II, thrombin	Homo sapiens	87-95
2845924-9	1988	Our observations clearly indicate that adrenaline directly or indirectly influences thrombin-induced changes in phosphoinositide metabolism.	Epinephrine	39-49	coagulation factor II, thrombin	Homo sapiens	84-92
3394838-6	1988	Vasopressin increased from 1.2 +/- 0.3 to 137 +/- 45 pg/ml and renin activity increased from 1.45 +/- 4.0 to 3.80 +/- 1.0 ng.ml-1.h-1 with no further changes in epinephrine, norepinephrine, and vasoactive intestinal polypeptide.	Epinephrine	161-172	arginine vasopressin	Homo sapiens	0-11
3140614-3	1988	The ACE inhibitors antagonised adrenaline-, carbachol- and A23187-stimulated PGI2 synthesis in the aorta and bladder (CGS14824A greater than captopril greater than CGS14831) but were without effect on trauma- or arachidonate-stimulated PGI2 synthesis.	Epinephrine	31-41	angiotensin I converting enzyme	Rattus norvegicus	4-7
3394838-6	1988	Vasopressin increased from 1.2 +/- 0.3 to 137 +/- 45 pg/ml and renin activity increased from 1.45 +/- 4.0 to 3.80 +/- 1.0 ng.ml-1.h-1 with no further changes in epinephrine, norepinephrine, and vasoactive intestinal polypeptide.	Epinephrine	161-172	renin	Homo sapiens	63-68
3290007-3	1988	After intensive therapy (HbA1 7.1 +/- 0.7%), the glucose threshold for epinephrine release consistently declined to values (46 +/- 2 mg/dl) below normal (P less than .01).	Epinephrine	71-82	hemoglobin subunit alpha 1	Homo sapiens	25-29
2902147-3	1988	The acute insulin response (AIR) to 2.5 g of arginine during this infusion of epinephrine was significantly higher (P less than 0.05) than in controls as were the acute glucagon response (AGR) (P less than 0.05) and the acute somatostatin response (ASLIR) (P less than 0.05).	Epinephrine	78-89	insulin	Canis lupus familiaris	10-17
3416914-2	1988	Both events were more pronounced in Ca2+-loaded rat muscles due to the addition of 0.5 microM adrenaline, an increase in the Ca2+ concentration in the solution and high muscle activity.	Epinephrine	94-104	carbonic anhydrase 2	Rattus norvegicus	36-39
3145321-17	1988	The swelling associated with the addition of adrenaline was also accompanied by an increase in K+, Na+, Cl- and rCl.	Epinephrine	45-55	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	Rattus norvegicus	104-106
3145321-17	1988	The swelling associated with the addition of adrenaline was also accompanied by an increase in K+, Na+, Cl- and rCl.	Epinephrine	45-55	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	Rattus norvegicus	112-115
3145321-21	1988	In addition to pH and oxygen saturation, rCl should therefore be considered as a possible triggering factor for the action of adrenaline.	Epinephrine	126-136	2'-deoxynucleoside 5'-phosphate N-hydrolase 1	Rattus norvegicus	41-44
3416914-2	1988	Both events were more pronounced in Ca2+-loaded rat muscles due to the addition of 0.5 microM adrenaline, an increase in the Ca2+ concentration in the solution and high muscle activity.	Epinephrine	94-104	carbonic anhydrase 2	Rattus norvegicus	125-128
2898856-4	1988	alpha- and beta-adrenergic blockade markedly modified insulin, glucose and non-esterified fatty acid responses to epinephrine and norepinephrine.	Epinephrine	114-125	insulin	Bos taurus	54-61
3372503-0	1988	Molecular cloning of cDNA and chromosomal assignment of the gene for human phenylethanolamine N-methyltransferase, the enzyme for epinephrine biosynthesis.	Epinephrine	130-141	phenylethanolamine N-methyltransferase	Homo sapiens	75-113
3372503-1	1988	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the synthesis of epinephrine from norepinephrine, the last step of catecholamine biosynthesis.	Epinephrine	86-97	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
3372503-1	1988	Phenylethanolamine N-methyltransferase (PNMT; EC 2.1.1.28) catalyzes the synthesis of epinephrine from norepinephrine, the last step of catecholamine biosynthesis.	Epinephrine	86-97	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
2899848-8	1988	Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN.	Epinephrine	50-61	proopiomelanocortin	Homo sapiens	108-112
3377082-11	1988	We also found that bombesin, epinephrine, and forskolin, but not carbachol, produced time- and dose-dependent release of PYY from these cultures.	Epinephrine	29-40	peptide YY	Canis lupus familiaris	121-124
3289990-0	1988	Influence of circulating epinephrine on absorption of subcutaneously injected insulin.	Epinephrine	25-36	insulin	Homo sapiens	78-85
2899848-8	1988	Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN.	Epinephrine	50-61	arginine vasopressin	Homo sapiens	117-128
2899848-8	1988	Results of this study support the hypothesis that epinephrine and/or norepinephrine regulate the release of ACTH and vasopressin via alpha-1- and alpha-2-adrenergic receptors associated with CRF- and VP-containing somata within the PVN.	Epinephrine	50-61	adrenoceptor alpha 1D	Homo sapiens	133-141
3137079-6	1988	Adrenal demedullation partly inhibited but did not completely abolish the effect of TRH on IBAT blood flow and lessened the increase in serum adrenaline caused by TRH.	Epinephrine	142-152	thyrotropin releasing hormone	Rattus norvegicus	163-166
3132162-12	1988	When alpha-thrombin stimulation of platelets was preceded by epinephrine, there was a potentiation of phospholipase C activation, Ca2+ mobilization and aggregation.	Epinephrine	61-72	coagulation factor II, thrombin	Homo sapiens	11-19
3044806-5	1988	The insulin leakage under the conditions of pharmacologic blockade of insulin secretion by means of epinephrine and propranolol provides a measure of complement-mediated cytotoxicity of human serum against rats islets in vitro.	Epinephrine	100-111	insulin	Homo sapiens	4-11
3408637-2	1988	We have previously shown that salbutamol induced hypokalaemia, like adrenaline induced hypokalaemia, is the result of stimulation of a membrane bound beta 2-adrenoreceptor linked to Na+/K+ ATPase.	Epinephrine	68-78	adrenoceptor beta 2	Homo sapiens	150-171
3410377-0	1988	[Changes in the potentiation effect of [D-Ala2, Met5]-enkephalin on pressor responses to l-adrenaline in adrenal-enucleated rats].	Epinephrine	89-101	proenkephalin	Rattus norvegicus	54-64
2898507-8	1988	Lipase secretion was stimulated by epinephrine and isoproterenol.	Epinephrine	35-46	lipase G, endothelial type	Rattus norvegicus	0-6
3410377-6	1988	2) In the control male and female rats, the 5 min pretreatment with enkephalin enhanced the pressor response to l-adrenaline, and the pressor effect of enkephalin plus l-adrenaline was suppressed by pretreatment with naloxone (2.5 mg/kg, s.c.).	Epinephrine	112-124	proenkephalin	Rattus norvegicus	68-78
3410377-7	1988	On the other hand, in the 3WAdMx male and female rats, the pressor effect of l-adrenaline was almost completely suppressed by pretreatment with enkephalin.	Epinephrine	77-89	proenkephalin	Rattus norvegicus	144-154
3388294-1	1988	In a medium containing 1 mM extracellular Ca2+ (Ca2+o), the prior addition of 0.5 microM adrenaline to quin 2-loaded human platelets increased both the rate and amplitude of the rise in cytosolic free Ca2+ (Ca2+i) in response to sub-threshold concentrations of thrombin and PAF and these effects were not prevented by blocking either fibrinogen binding and aggregation or cyclo-oxygenase.	Epinephrine	89-99	coagulation factor II, thrombin	Homo sapiens	261-269
2835776-1	1988	The human gene for phenylethanolamine N-methyltransferase (hPNMT), responsible for the conversion of norepinephrine to epinephrine, has been cloned and the complete nucleotide sequence has been determined.	Epinephrine	104-115	phenylethanolamine N-methyltransferase	Homo sapiens	19-57
2835776-1	1988	The human gene for phenylethanolamine N-methyltransferase (hPNMT), responsible for the conversion of norepinephrine to epinephrine, has been cloned and the complete nucleotide sequence has been determined.	Epinephrine	104-115	phenylethanolamine N-methyltransferase	Homo sapiens	59-64
3133810-3	1988	Because infusion of epinephrine has been shown to increase t-PA levels, we examined the role of endogenous catecholamine mediation of t-PA release by desmopressin.	Epinephrine	20-31	chromosome 20 open reading frame 181	Homo sapiens	59-63
3388294-1	1988	In a medium containing 1 mM extracellular Ca2+ (Ca2+o), the prior addition of 0.5 microM adrenaline to quin 2-loaded human platelets increased both the rate and amplitude of the rise in cytosolic free Ca2+ (Ca2+i) in response to sub-threshold concentrations of thrombin and PAF and these effects were not prevented by blocking either fibrinogen binding and aggregation or cyclo-oxygenase.	Epinephrine	89-99	fibrinogen beta chain	Homo sapiens	334-344
2830284-4	1988	Epinephrine added following thrombin desensitization restored both the ability of thrombin to release Ca2+ stores and stimulate inositol phospholipid hydrolysis.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	28-36
2839012-6	1988	Catecholamines (epinephrine, norepinephrine and isoproterenol) reduced the basal secretion of ANP, whereas acetylcholine stimulated the release of ANP.	Epinephrine	16-27	natriuretic peptide A	Rattus norvegicus	94-97
3128145-2	1988	Epinephrine resulted in an increased MAP over normal saline and TRH at one minute after treatment (P less than .001).	Epinephrine	0-11	thyrotropin releasing hormone	Oryctolagus cuniculus	64-67
3128145-3	1988	TRH resulted in an increased MAP over normal saline at two minutes (P less than .017) and over epinephrine at four minutes (P less than .011) after treatment.	Epinephrine	95-106	thyrotropin releasing hormone	Oryctolagus cuniculus	0-3
2978742-0	1988	Response of atrial natriuretic peptide to adrenaline and noradrenaline infusion in man.	Epinephrine	42-52	natriuretic peptide A	Homo sapiens	12-38
2978742-2	1988	Atrial natriuretic peptide (ANP) levels were significantly increased during both adrenaline and noradrenaline infusions, in the physiological range, in normal subjects and in patients with essential hypertension.	Epinephrine	81-91	natriuretic peptide A	Homo sapiens	0-26
2978742-2	1988	Atrial natriuretic peptide (ANP) levels were significantly increased during both adrenaline and noradrenaline infusions, in the physiological range, in normal subjects and in patients with essential hypertension.	Epinephrine	81-91	natriuretic peptide A	Homo sapiens	28-31
3380104-6	1988	Adjacent sections were examined for the mRNAs encoding enkephalin and phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	160-171	phenylethanolamine N-methyltransferase	Bos taurus	70-108
3380104-6	1988	Adjacent sections were examined for the mRNAs encoding enkephalin and phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes the formation of epinephrine from norepinephrine.	Epinephrine	160-171	phenylethanolamine N-methyltransferase	Bos taurus	110-114
2830284-4	1988	Epinephrine added following thrombin desensitization restored both the ability of thrombin to release Ca2+ stores and stimulate inositol phospholipid hydrolysis.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	82-90
3279810-1	1988	Experiments were designed to test the hypothesis that epinephrine may act directly on cardiac or pulmonary adrenoceptors to alter the release of a humoral substance that in turn influences renin secretion.	Epinephrine	54-65	renin	Canis lupus familiaris	189-194
3279810-4	1988	At epinephrine infusion rates of 15 and 75 ng.kg-1.min-1, epinephrine-induced changes in renin secretion rates were dose dependent but were independent of the site of infusion.	Epinephrine	3-14	renin	Canis lupus familiaris	89-94
3279810-4	1988	At epinephrine infusion rates of 15 and 75 ng.kg-1.min-1, epinephrine-induced changes in renin secretion rates were dose dependent but were independent of the site of infusion.	Epinephrine	58-69	renin	Canis lupus familiaris	89-94
2830284-6	1988	Pretreatment of platelets with phorbol dibutyrate at concentrations which specifically activate protein kinase C increased the rate of desensitization of the thrombin-induced release of Ca2+ stores and abolished the ability of epinephrine to restore the thrombin response.	Epinephrine	227-238	coagulation factor II, thrombin	Homo sapiens	158-166
2830284-6	1988	Pretreatment of platelets with phorbol dibutyrate at concentrations which specifically activate protein kinase C increased the rate of desensitization of the thrombin-induced release of Ca2+ stores and abolished the ability of epinephrine to restore the thrombin response.	Epinephrine	227-238	coagulation factor II, thrombin	Homo sapiens	254-262
2830284-9	1988	This protein is involved in thrombin stimulation of phospholipase C but is not directly stimulatory since epinephrine alone does not activate this enzyme.	Epinephrine	106-117	coagulation factor II, thrombin	Homo sapiens	28-36
3279810-7	1988	Intravenous epinephrine infusion at 50 ng.kg-1.min-1 increased plasma renin activity nearly 1.5-fold.	Epinephrine	12-23	renin	Canis lupus familiaris	70-75
3127518-3	1988	Adrenaline blocked the K+-stimulated release of VIP when used at a concentration of 0.1 mumol/l; however, at a higher concentration (10 mumol/l) adrenaline stimulated the basal release of VIP.	Epinephrine	0-10	vasoactive intestinal peptide	Rattus norvegicus	48-51
2449342-0	1988	Epinephrine mediates the growth hormone-releasing effect of galanin in infant rats.	Epinephrine	0-11	growth hormone 1	Homo sapiens	25-39
2449342-0	1988	Epinephrine mediates the growth hormone-releasing effect of galanin in infant rats.	Epinephrine	0-11	galanin and GMAP prepropeptide	Rattus norvegicus	60-67
3127518-3	1988	Adrenaline blocked the K+-stimulated release of VIP when used at a concentration of 0.1 mumol/l; however, at a higher concentration (10 mumol/l) adrenaline stimulated the basal release of VIP.	Epinephrine	145-155	vasoactive intestinal peptide	Rattus norvegicus	188-191
3127518-5	1988	The suggestion that adrenaline might be the endogenous inhibitor of the release of VIP, mediating the diurnal variation in the effect of K+, was supported by studies where 50 mmol K+/l was perifused concomitantly with an alpha 2-antagonist, restoring the VIP response to K+ in light-phase hypothalami.	Epinephrine	20-30	vasoactive intestinal peptide	Rattus norvegicus	83-86
3127518-5	1988	The suggestion that adrenaline might be the endogenous inhibitor of the release of VIP, mediating the diurnal variation in the effect of K+, was supported by studies where 50 mmol K+/l was perifused concomitantly with an alpha 2-antagonist, restoring the VIP response to K+ in light-phase hypothalami.	Epinephrine	20-30	vasoactive intestinal peptide	Rattus norvegicus	255-258
3127518-6	1988	In conclusion, adrenaline has a dual role in the control of VIP release and may function to inhibit the K+-stimulated release of VIP in our system.	Epinephrine	15-25	vasoactive intestinal peptide	Rattus norvegicus	60-63
3127518-6	1988	In conclusion, adrenaline has a dual role in the control of VIP release and may function to inhibit the K+-stimulated release of VIP in our system.	Epinephrine	15-25	vasoactive intestinal peptide	Rattus norvegicus	129-132
2969081-8	1988	The data indicate that heparins discriminate platelet activating factor and adrenaline-induced inhibition of adenylate cyclase from the inhibitory action of thrombin and delineate different structural requirements for the interaction of heparins with the adenylate cyclase system and antithrombin III.	Epinephrine	76-86	serpin family C member 1	Homo sapiens	284-300
2830619-5	1988	The kin- and cyc- cells exhibited only homologous desensitization, and much higher concentrations of epinephrine were required to elicit the homologous desensitization in the variants relative to the heterologous desensitization of the WT.	Epinephrine	101-112	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	13-16
2831879-2	1988	Unlike thrombin, however, epinephrine is incapable of directly activating phospholipase C, but is well known to potentiate the effects of thrombin on this enzyme and other subsequent steps of platelet activation.	Epinephrine	26-37	coagulation factor II, thrombin	Homo sapiens	138-146
3162323-0	1988	Epinephrine enhances Ca2+ current-regulated Ca2+ release and Ca2+ reuptake in rat ventricular myocytes.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	21-24
3162323-0	1988	Epinephrine enhances Ca2+ current-regulated Ca2+ release and Ca2+ reuptake in rat ventricular myocytes.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	44-47
3162323-0	1988	Epinephrine enhances Ca2+ current-regulated Ca2+ release and Ca2+ reuptake in rat ventricular myocytes.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	44-47
3162323-9	1988	Epinephrine (1 microM) increased the Ca2+ current and the Ca2+ transients, accelerated the rate of decline of the Ca2+ transients at potentials between -30 and +70 mV, and reduced the intracellular [Ca2+] below baseline at potentials positive to +80 or negative to -40 mV, where clamp pulses did not elicit any Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	37-40
3162323-9	1988	Epinephrine (1 microM) increased the Ca2+ current and the Ca2+ transients, accelerated the rate of decline of the Ca2+ transients at potentials between -30 and +70 mV, and reduced the intracellular [Ca2+] below baseline at potentials positive to +80 or negative to -40 mV, where clamp pulses did not elicit any Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	58-61
3162323-9	1988	Epinephrine (1 microM) increased the Ca2+ current and the Ca2+ transients, accelerated the rate of decline of the Ca2+ transients at potentials between -30 and +70 mV, and reduced the intracellular [Ca2+] below baseline at potentials positive to +80 or negative to -40 mV, where clamp pulses did not elicit any Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	58-61
3162323-9	1988	Epinephrine (1 microM) increased the Ca2+ current and the Ca2+ transients, accelerated the rate of decline of the Ca2+ transients at potentials between -30 and +70 mV, and reduced the intracellular [Ca2+] below baseline at potentials positive to +80 or negative to -40 mV, where clamp pulses did not elicit any Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	58-61
3162323-9	1988	Epinephrine (1 microM) increased the Ca2+ current and the Ca2+ transients, accelerated the rate of decline of the Ca2+ transients at potentials between -30 and +70 mV, and reduced the intracellular [Ca2+] below baseline at potentials positive to +80 or negative to -40 mV, where clamp pulses did not elicit any Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	58-61
3162323-12	1988	Consistent with a graded Ca2+-induced Ca2+ release we find that epinephrine increases the internal Ca2+ release by increasing the Ca2+ current.	Epinephrine	64-75	carbonic anhydrase 2	Rattus norvegicus	25-28
3162323-12	1988	Consistent with a graded Ca2+-induced Ca2+ release we find that epinephrine increases the internal Ca2+ release by increasing the Ca2+ current.	Epinephrine	64-75	carbonic anhydrase 2	Rattus norvegicus	38-41
2831879-6	1988	The response to thrombin desensitized over a period of minutes, and after this had occurred, epinephrine was able to activate phospholipase C and induce the release of intracellular Ca2+.	Epinephrine	93-104	coagulation factor II, thrombin	Homo sapiens	16-24
3162323-12	1988	Consistent with a graded Ca2+-induced Ca2+ release we find that epinephrine increases the internal Ca2+ release by increasing the Ca2+ current.	Epinephrine	64-75	carbonic anhydrase 2	Rattus norvegicus	38-41
2831879-7	1988	This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin.	Epinephrine	17-28	coagulation factor II, thrombin	Homo sapiens	50-58
3162323-12	1988	Consistent with a graded Ca2+-induced Ca2+ release we find that epinephrine increases the internal Ca2+ release by increasing the Ca2+ current.	Epinephrine	64-75	carbonic anhydrase 2	Rattus norvegicus	38-41
3162323-13	1988	Epinephrine may also increase the Ca2+ content of the sarcoplasmic reticulum that may, in turn, increase the Ca2+-induced Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	34-37
3162323-13	1988	Epinephrine may also increase the Ca2+ content of the sarcoplasmic reticulum that may, in turn, increase the Ca2+-induced Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	109-112
3162323-13	1988	Epinephrine may also increase the Ca2+ content of the sarcoplasmic reticulum that may, in turn, increase the Ca2+-induced Ca2+ release.	Epinephrine	0-11	carbonic anhydrase 2	Rattus norvegicus	109-112
3162323-14	1988	The relaxant effect of epinephrine appears to be caused by enhanced rate of Ca2+ resequestration and is mediated by adenylate cyclase system.	Epinephrine	23-34	carbonic anhydrase 2	Rattus norvegicus	76-79
2831879-7	1988	This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin.	Epinephrine	17-28	coagulation factor II, thrombin	Homo sapiens	196-204
2831879-7	1988	This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin.	Epinephrine	181-192	coagulation factor II, thrombin	Homo sapiens	196-204
2831879-7	1988	This showed that epinephrine was able to recouple thrombin receptors to phospholipase C, and this appeared to be mediated by the same mechanism which is involved in potentiation by epinephrine of thrombin-stimulation of phospholipase C. These effects of epinephrine were not altered by inhibition of the Na+/H+ antiporter with ethylisopropylamiloride or by use of the Na+/H+ ionophore, monensin.	Epinephrine	181-192	coagulation factor II, thrombin	Homo sapiens	196-204
2831879-8	1988	We conclude that epinephrine potentiates thrombin-induced responses by a mechanism which is unrelated to its effects on the Na+/H+ antiporter, and this is not a requirement for thrombin-induced phospholipase C activation.	Epinephrine	17-28	coagulation factor II, thrombin	Homo sapiens	41-49
2897354-8	1988	Epinephrine was detected in spleen and heart after administration of T-2 toxin.	Epinephrine	0-11	brachyury 2	Rattus norvegicus	69-72
3346339-5	1988	Met-enkephalin increased specific antibody-dependent phagocytosis in a dose-dependent fashion; the optimal dose was found to be 10(-8) M. Epinephrine diminished phagocytosis in a dose-dependent manner exhibiting a maximal inhibition at 10(-4)-10(-5) M. This inhibition can be blocked by propranolol.	Epinephrine	138-149	pro-opiomelanocortin-alpha	Mus musculus	0-14
3346832-2	1988	NPY produced a concentration-dependent inhibition of nicotine-stimulated norepinephrine and epinephrine release from bovine chromaffin cells with IC50 (concentration of NPY which inhibits 50% of maximum release of catecholamines) values of 1.8 x 10(-9) M and 1.7 x 10(-9) M, respectively.	Epinephrine	76-87	neuropeptide Y	Bos taurus	0-3
3335518-8	1988	The endogenous rate of norepinephrine production likely represents epinephrine-supported dopamine beta-monooxygenase turnover.	Epinephrine	26-37	dopamine beta-hydroxylase	Bos taurus	89-116
3377882-1	1988	Vasopressin, angiotensin II, epinephrine (alpha 1-adrenergic action) and phorbol 12-myristate 13-acetate (PMA) induce increases in membrane-associated protein kinase C activity concomitant with decreases in the cytosolic activity.	Epinephrine	29-40	arginine vasopressin	Rattus norvegicus	0-11
2894779-1	1988	The effect of intravenous infusion of epinephrine, either alone or together with various doses of phentolamine or propranolol, on the secretion of both glucagon and insulin was determined in six sheep.	Epinephrine	38-49	LOC105613195	Ovis aries	165-172
2894779-2	1988	Intravenous infusion of epinephrine alone caused increases in plasma glucagon and glucose concentrations and produced a slight but significant decrease in plasma insulin concentration.	Epinephrine	24-35	LOC105613195	Ovis aries	162-169
2851918-0	1988	Neuropeptide Y (NPY) induced inhibition of preganglionic nerve stimulation evoked release of adrenalin and noradrenaline in the pithed rat.	Epinephrine	93-102	neuropeptide Y	Rattus norvegicus	0-14
2903616-7	1988	By using this method it was demonstrated that insulin resistance occurred for at least 12 hours after a hypoglycemic event in patients with IDDM, and that adrenaline caused immediate insulin resistance which, however, faded out within four to six hours, while GH exerted no immediate effect on insulin sensitivity but caused marked and sustained insulin resistance after a lag period of about four hours.	Epinephrine	155-165	insulin	Homo sapiens	183-190
2903616-7	1988	By using this method it was demonstrated that insulin resistance occurred for at least 12 hours after a hypoglycemic event in patients with IDDM, and that adrenaline caused immediate insulin resistance which, however, faded out within four to six hours, while GH exerted no immediate effect on insulin sensitivity but caused marked and sustained insulin resistance after a lag period of about four hours.	Epinephrine	155-165	insulin	Homo sapiens	183-190
2903616-7	1988	By using this method it was demonstrated that insulin resistance occurred for at least 12 hours after a hypoglycemic event in patients with IDDM, and that adrenaline caused immediate insulin resistance which, however, faded out within four to six hours, while GH exerted no immediate effect on insulin sensitivity but caused marked and sustained insulin resistance after a lag period of about four hours.	Epinephrine	155-165	insulin	Homo sapiens	183-190
2851918-0	1988	Neuropeptide Y (NPY) induced inhibition of preganglionic nerve stimulation evoked release of adrenalin and noradrenaline in the pithed rat.	Epinephrine	93-102	neuropeptide Y	Rattus norvegicus	16-19
2892427-3	1988	Interruption of the renin-angiotensin system with the converting enzyme inhibitor captopril or the receptor antagonist saralasin significantly attenuated the pressor responses to adrenal stimulation and injected epinephrine to an equivalent extent.	Epinephrine	212-223	renin	Rattus norvegicus	20-25
2898866-1	1988	Incubation of epididymal fat tissue slices with somatostatin (SS) led to the inhibition of epinephrine-induced release of free fatty acids (FFA) and glycerol in a dose-dependent manner.	Epinephrine	91-102	somatostatin	Homo sapiens	48-60
2907712-4	1988	The alpha- and beta-adrenergic properties of P11 are characterized by using adrenergic and dopaminergic agonists and antagonists (adrenaline, isoproterenol, phenylephrine, propranolol, phentolamine, apomorphine and pimozide) in the different experimental setups.	Epinephrine	130-140	S100 calcium binding protein A10	Rattus norvegicus	45-48
2892427-5	1988	Instead angiotensin II appears to interact at the level of the vascular smooth muscle, because reinfusion of angiotensin II (20 ng.kg-1.min-1 iv) in captopril-treated animals restored responsiveness to stimulation and epinephrine.	Epinephrine	218-229	angiotensinogen	Rattus norvegicus	109-123
2892427-8	1988	The results suggest that endogenously formed angiotensin II facilitates the vasoconstrictor activity of epinephrine by increasing vascular tone.	Epinephrine	104-115	angiotensinogen	Rattus norvegicus	45-59
3248234-6	1988	Inhibition of central epinephrine synthesis with SKF 64 139, which selectively blocks phenylethanolamine-N-methyltransferase, partially decreased the PRL release induced by FK 33824.	Epinephrine	22-33	phenylethanolamine-N-methyltransferase	Rattus norvegicus	86-124
2852942-3	1988	The level of circulating catecholamines (epinephrine, norepinephrine) was significantly higher in patients were severe HF, which probably caused more evident decrease in lymphocyte beta 2-adrenoceptors density in these patients.	Epinephrine	41-52	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	181-187
2852518-2	1988	Adrenaline enhanced the basal and potentiated the hCG-induced T release.	Epinephrine	0-10	hypertrichosis 2 (generalised, congenital)	Homo sapiens	50-53
3248234-6	1988	Inhibition of central epinephrine synthesis with SKF 64 139, which selectively blocks phenylethanolamine-N-methyltransferase, partially decreased the PRL release induced by FK 33824.	Epinephrine	22-33	prolactin	Rattus norvegicus	150-153
2891452-5	1988	The plasma levels of norepinephrine and epinephrine were increased by TRH, while there was no change in plasma renin activity or vasopressin.	Epinephrine	24-35	thyrotropin releasing hormone	Rattus norvegicus	70-73
3342087-1	1988	SKF 64139, a specific inhibitor of the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), has been widely used as a pharmacological tool for studying the characteristics of epinephrine-containing neurons.	Epinephrine	39-50	phenylethanolamine-N-methyltransferase	Rattus norvegicus	72-110
3342087-1	1988	SKF 64139, a specific inhibitor of the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), has been widely used as a pharmacological tool for studying the characteristics of epinephrine-containing neurons.	Epinephrine	39-50	phenylethanolamine-N-methyltransferase	Rattus norvegicus	112-116
3336016-1	1988	beta-Phenylethanolamines have long been known to be substrates for the enzyme that converts norepinephrine to epinephrine (phenylethanolamine N-methyltransferase, PNMT, EC 2.1.1.28).	Epinephrine	95-106	phenylethanolamine N-methyltransferase	Homo sapiens	123-161
2848631-2	1988	NPY has been localized in neurons that synthesize norepinephrine or epinephrine and also in many cell bodies which are not catecholaminergic.	Epinephrine	53-64	neuropeptide Y	Homo sapiens	0-3
2841207-3	1988	Adrenaline-induced increases in plasma cyclic AMP (a beta 2-mediated in vivo response) also tended to be reduced during normal pregnancy.	Epinephrine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	53-59
3056815-5	1988	The hormonal responses of epinephrine, norepinephrine, prolactin, hGH, and cortisol were attenuated following proinsulin.	Epinephrine	26-37	insulin	Homo sapiens	110-120
3336016-1	1988	beta-Phenylethanolamines have long been known to be substrates for the enzyme that converts norepinephrine to epinephrine (phenylethanolamine N-methyltransferase, PNMT, EC 2.1.1.28).	Epinephrine	95-106	phenylethanolamine N-methyltransferase	Homo sapiens	163-167
3184554-1	1988	The effects of monoamine oxidase-A (MAO-A) inhibitors with epinephrine on intraocular pressure in the pigmented rabbit were studied.	Epinephrine	59-70	amine oxidase [flavin-containing] A	Oryctolagus cuniculus	36-41
3184554-9	1988	These results indicated that MAO-A inhibitors potentiated the ocular hypotensive effects of epinephrine, and that the coadministration of a reversible MAO-A inhibitor with epinephrine might be useful for patients with glaucoma.	Epinephrine	92-103	monoamine oxidase A	Homo sapiens	29-34
3184554-9	1988	These results indicated that MAO-A inhibitors potentiated the ocular hypotensive effects of epinephrine, and that the coadministration of a reversible MAO-A inhibitor with epinephrine might be useful for patients with glaucoma.	Epinephrine	172-183	monoamine oxidase A	Homo sapiens	151-156
2842568-3	1988	While ANP alone (1 pM-100 nM) had no effect, ANP significantly potentiated thrombin (0.4 units/ml)-, epinephrine (15 microM)- and ADP (2 or 10 microM)-induced aggregation.	Epinephrine	101-112	natriuretic peptide A	Homo sapiens	45-48
3367684-1	1988	Neuropeptide Y (NPY) is a vasoconstrictor present in the sympatho-adrenomedullary system and may be co-released with norepinephrine (NE) and epinephrine (EPI) during sympathetic activation.	Epinephrine	120-131	neuropeptide Y	Rattus norvegicus	0-14
3367684-1	1988	Neuropeptide Y (NPY) is a vasoconstrictor present in the sympatho-adrenomedullary system and may be co-released with norepinephrine (NE) and epinephrine (EPI) during sympathetic activation.	Epinephrine	120-131	neuropeptide Y	Rattus norvegicus	16-19
2894072-7	1988	Adrenaline increased gastric acid production in both pig and human parietal cells, most likely through a beta-2 receptor on the parietal cell.	Epinephrine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	105-111
2896345-4	1988	These results indicate that TRH, acting within the central nervous system, can block neurally-mediated hyperglycemia in addition to its previously reported actions to elicit systemic hypoglycemia in normoglycemic mice and to antagonize epinephrine-stimulated hyperglycemia in these animals.	Epinephrine	236-247	thyrotropin releasing hormone	Mus musculus	28-31
3043553-10	1988	Synthesis of epinephrine in the neuronal pool found primarily in the medulla may be enhanced due to increased PNMT activity in the presence of elevated corticosteroids.	Epinephrine	13-24	phenylethanolamine N-methyltransferase	Homo sapiens	110-114
2451400-4	1987	Adrenaline and isoproterenol (a beta-agonist) increase the blood level of alpha 2-APG and CRP dose-dependently probably due to a mechanism involved in the sequence of an inflammatory process, too.	Epinephrine	0-10	C-reactive protein	Rattus norvegicus	74-93
3440206-2	1987	To address this issue, we have established an in vitro system of fetal medulla oblongata (MO) to follow development of the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT).	Epinephrine	123-134	phenylethanolamine-N-methyltransferase	Rattus norvegicus	156-194
3123010-0	1987	Thyrotropin-releasing hormone potently reverses epinephrine-stimulated hyperglycemia in mice.	Epinephrine	48-59	thyrotropin releasing hormone	Mus musculus	0-29
3123010-1	1987	Intracerebroventricular microinjection of thyrotropin-releasing hormone (TRH) potently blocked the development of, as well as promptly reversed, epinephrine-stimulated hyperglycemia in mice.	Epinephrine	145-156	thyrotropin releasing hormone	Mus musculus	42-71
3123010-1	1987	Intracerebroventricular microinjection of thyrotropin-releasing hormone (TRH) potently blocked the development of, as well as promptly reversed, epinephrine-stimulated hyperglycemia in mice.	Epinephrine	145-156	thyrotropin releasing hormone	Mus musculus	73-76
3123010-4	1987	Furthermore, the effect of TRH to reverse epinephrine-stimulated hyperglycemia appeared to be mediated by combined action of peripheral sympathetic and parasympathetic mechanisms to stimulate insulin release from the pancreas, since only complete blockade of the central autonomic outflow, but not selective perturbation of the sympathetic or parasympathetic outflow, or depletion of pancreatic insulin could substantially attenuate the antihyperglycemic action.	Epinephrine	42-53	thyrotropin releasing hormone	Mus musculus	27-30
2966106-5	1987	However, platelet CR3 does not merely bind C3bi, but the binding of the OKM1 antibody to platelet CR3 selectively blocks platelet functions of aggregation and serotonin release induced by arachadonic acid but not by other ligands (ristocetin, ADP, L-epinephrine, collagen and thrombin).	Epinephrine	248-261	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	98-101
3438574-1	1987	A role of calmodulin in the process of the glycogenolysis induced by adrenaline was investigated in rat submandibular gland.	Epinephrine	69-79	calmodulin 1	Rattus norvegicus	10-20
3440570-0	1987	Correlation of daily urinary excretion of met-enkephalin-like immunoreactivity and epinephrine in men.	Epinephrine	83-94	proopiomelanocortin	Homo sapiens	42-56
2891801-2	1987	Antisera directed against the enzymes tyrosine hydroxylase (TH), which converts tyrosine to DOPA, and phenylethanolamine N-methyl-transferase (PNMT), which converts norepinephrine to epinephrine, were used with conventional immunohistochemical techniques.	Epinephrine	168-179	phenylethanolamine N-methyltransferase	Mustela putorius furo	102-141
2891801-2	1987	Antisera directed against the enzymes tyrosine hydroxylase (TH), which converts tyrosine to DOPA, and phenylethanolamine N-methyl-transferase (PNMT), which converts norepinephrine to epinephrine, were used with conventional immunohistochemical techniques.	Epinephrine	168-179	phenylethanolamine N-methyltransferase	Mustela putorius furo	143-147
2826278-2	1987	The present data show that the natural beta-agonist epinephrine (EPI) stimulates GH release through an additional alpha-adrenergic mechanism.	Epinephrine	52-63	gonadotropin releasing hormone receptor	Rattus norvegicus	81-83
2446707-4	1987	Administration of the alpha 2-adrenoceptor antagonist idazoxan and the MAO inhibitor tranylcypromine elicited increases in hypothalamic extracellular levels of both adrenaline and noradrenaline by 208% and 229%, respectively.	Epinephrine	165-175	monoamine oxidase A	Rattus norvegicus	71-74
2446508-3	1987	Carbachol and somatostatin (SRIF) markedly inhibited the epinephrine effect on both peptide release and cAMP content.	Epinephrine	57-68	somatostatin	Canis lupus familiaris	14-26
2894798-1	1987	Ornithine decarboxylase activity of rat lung was induced by s.c. injection of acetylcholine, norepinephrine, epinephrine, dopamine, serotonin, vasopressin, angiotensin II, and adrenocorticotropic hormone, but not by gonadotropin, aldosterone, corticosterone or hydrocortisone.	Epinephrine	96-107	ornithine decarboxylase 1	Rattus norvegicus	0-23
2833189-3	1987	These findings suggest that part of the pressor response of high doses of angiotensin II is caused by the liberation of endogenous noradrenaline from the sympathetic nerve endings, but not by that of adrenaline from the adrenal medulla.	Epinephrine	134-144	angiotensinogen	Rattus norvegicus	74-88
3426563-1	1987	Tumour necrosis factor (TNF) did not stimulate lipolysis in isolated rat adipocytes, though preincubation with TNF increased adrenaline-stimulated fatty acid release.	Epinephrine	125-135	tumor necrosis factor	Rattus norvegicus	111-114
2822282-1	1987	The relation between the induction of phosphatidylinositol labelling and ureagenesis by epinephrine (alpha 1-adrenergic action), vasopressin, and angiotensin II was studied in liver cells.	Epinephrine	88-99	angiotensinogen	Homo sapiens	101-160
3319049-1	1987	The present model of epinephrine containing and PNMT containing neurons in rat brain (and by extension other species) implies that epinephrine is primarily a postsynaptic metabolite of norepinephrine in forebrain due to the probable postsynaptic localization of PNMT.	Epinephrine	131-142	phenylethanolamine-N-methyltransferase	Rattus norvegicus	48-52
3319049-1	1987	The present model of epinephrine containing and PNMT containing neurons in rat brain (and by extension other species) implies that epinephrine is primarily a postsynaptic metabolite of norepinephrine in forebrain due to the probable postsynaptic localization of PNMT.	Epinephrine	131-142	phenylethanolamine-N-methyltransferase	Rattus norvegicus	262-266
3319049-7	1987	The balance of norepinephrine to epinephrine found in vesicles in these terminals would be a function of intraneuronal PNMT activity, MAO activity and reuptake which would be the major regulator of intraneuronal norepinephrine concentrations.	Epinephrine	18-29	phenylethanolamine-N-methyltransferase	Rattus norvegicus	119-123
3319049-7	1987	The balance of norepinephrine to epinephrine found in vesicles in these terminals would be a function of intraneuronal PNMT activity, MAO activity and reuptake which would be the major regulator of intraneuronal norepinephrine concentrations.	Epinephrine	18-29	monoamine oxidase A	Rattus norvegicus	134-137
3312277-0	1987	Adenosine 3",5"-monophosphate, prostaglandins, and epinephrine stimulate the secretion of immunoreactive gonadotropin-releasing hormone from cultured human placental cells.	Epinephrine	51-62	gonadotropin releasing hormone 1	Homo sapiens	105-135
3319049-13	1987	Based on the distribution of PNMT and its association with major noradrenergic fiber tracts, epinephrine can be considered a site-selective metabolite of physiological and neuronal importance.	Epinephrine	93-104	phenylethanolamine-N-methyltransferase	Rattus norvegicus	29-33
2961218-7	1987	WP resuspended in the presence of 2 mmol/l Ca2+ seldom responded to PAF alone, as previously shown by others, but full aggregation could be induced by concomitant addition of subthreshold concentrations of PAF (25-50 nM) and epinephrine (1 microM).	Epinephrine	225-236	PCNA clamp associated factor	Homo sapiens	206-209
2890079-6	1987	The intravenous injection of ovine GH (100 micrograms/kg) or equimolar amounts of SRIF (7.5 micrograms/kg) produced in the hepatic portal circulation a transient but statistically significant rise of serotonin and a concomitant reduction in the concentration of dopamine, norepinephrine, and epinephrine.	Epinephrine	275-286	somatotropin	Canis lupus familiaris	35-37
3309520-0	1987	Renin secretion in intact dogs following incubation of epinephrine in blood in vivo.	Epinephrine	55-66	renin	Canis lupus familiaris	0-5
3309520-1	1987	Previous experiments have shown that epinephrine-induced renin secretion in vivo apparently is initiated by activation of extrarenal adrenoceptors.	Epinephrine	37-48	renin	Canis lupus familiaris	57-62
3309520-8	1987	Intravenous infusion of epinephrine at 25 ng X kg-1 X min-1 increased renin secretion significantly.	Epinephrine	24-35	renin	Canis lupus familiaris	70-75
2821002-4	1987	Binding of 125I-fibronectin was also decreased in cultures treated with epinephrine, isoproterenol, or forskolin.	Epinephrine	72-83	fibronectin 1	Homo sapiens	16-27
2820806-1	1987	Treatment of intact human platelets with the tumour-promoting phorbol ester, phorbol 12-myristate 13-acetate (PMA), specifically inhibited PGD2-induced cyclic AMP formation without affecting the regulation of cyclic AMP metabolism by PGI2, PGE1, 6-keto-PGE1, adenosine or adrenaline.	Epinephrine	272-282	prostaglandin D2 synthase	Homo sapiens	139-143
3426346-1	1987	Using the oil immersion technique, the role of neuronal uptake, monoamine oxidase and COMT in the inactivation of 2 concentrations (0.23 and 2.3 mumol/l) of noradrenaline and adrenaline was determined by the prolongation of the inactivation time caused by cocaine (12 mumol/l), pargyline (1 mmol/l) and U-0521 (50 mumol/l), respectively.	Epinephrine	160-170	catechol-O-methyltransferase	Canis lupus familiaris	86-90
2822046-2	1987	In a previous paper we have shown that the beta2 receptor density of mononuclear cells of uremic patients is significantly increased despite a significant increase in plasma epinephrine, suggesting that an endogenous substance could interfere and disregulate the beta 2 receptor density.	Epinephrine	174-185	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	43-48
2826568-4	1987	beta-Endorphin also markedly increased plasma concentrations of epinephrine, norepinephrine and, to a lesser extent, dopamine.	Epinephrine	64-75	proopiomelanocortin	Homo sapiens	0-14
2826568-5	1987	A significant positive correlation was demonstrated between plasma glucose and plasma epinephrine responses to increasing doses of intracisternally administered beta-endorphin.	Epinephrine	86-97	proopiomelanocortin	Homo sapiens	161-175
2961012-2	1987	ANF secretion was stimulated by as little as 1 nM epinephrine (EPI) or the beta-adrenergic agonist isoproterenol (ISO).	Epinephrine	50-61	natriuretic peptide A	Rattus norvegicus	0-3
3308941-1	1987	Central nervous system function during insulin-induced reductions in plasma glucose was studied by measuring plasma epinephrine concentrations and testing cognitive function.	Epinephrine	116-127	insulin	Homo sapiens	39-46
2826868-1	1987	Adrenaline and noradrenaline excretion in 24-hour urine and blood ACTH levels were examined with respect to behavior types in young people in the course of adaptation to lasting psychoemotional and physical stress exposure.	Epinephrine	0-10	proopiomelanocortin	Homo sapiens	66-70
2889453-2	1987	In quiescent cells, epinephrine (EN) and dopamine (DA) markedly increased the NGF content in the conditioned medium (CM).	Epinephrine	20-31	nerve growth factor	Mus musculus	78-81
3619096-8	1987	Addition of 0.2 mg epinephrine prolonged by a significant 25% regression time to L-2 level.	Epinephrine	19-30	immunoglobulin kappa variable 3-15	Homo sapiens	81-84
2962893-1	1987	When repeated epinephrine infusions are given to normal dogs as a partial stress model, there is exaggerated hyperglycaemia, associated with reduced plasma insulin levels and markedly decreased glucose clearance.	Epinephrine	14-25	insulin	Canis lupus familiaris	156-163
2886385-8	1987	Accumulation of cAMP by HIT cells was inhibited in a concentration-dependent manner by PGE2 with an IC50 of approximately 1 X 10(-9) M. Insulin secretion by HIT cells during static incubations with 11.1 mM glucose was also inhibited by PGE2 in a concentration-dependent manner with an IC50 of 1 X 10(-9) M. PGE2 was more potent than epinephrine but less potent than somatostatin in this regard.	Epinephrine	333-344	insulin	Cavia porcellus	136-143
2962893-10	1987	In normal dogs, beta endorphin diminished the insulin response to the first epinephrine infusion (p less than 0.02), and abolished this response to the second (p less than 0.05).	Epinephrine	76-87	insulin	Canis lupus familiaris	46-53
3307773-5	1987	Furthermore, it showed that adrenaline also increased insulin receptor affinity.	Epinephrine	28-38	insulin receptor	Homo sapiens	54-70
2890184-3	1987	Somatostatin potentiates the venoconstrictive activity of noradrenaline, adrenaline and dopamine, but not that of 5-hydroxytryptamine and tyramine.	Epinephrine	61-71	somatostatin	Homo sapiens	0-12
3307773-6	1987	The negative co-operativity affinity profile demonstrated that adrenaline caused a rise in only the upper limit average affinity, Ki, of the insulin receptor.	Epinephrine	63-73	insulin receptor	Homo sapiens	141-157
3632150-0	1987	Lactic acidosis and insulin resistance associated with epinephrine administration in a patient with non-insulin-dependent diabetes mellitus.	Epinephrine	55-66	insulin	Homo sapiens	20-27
3306472-2	1987	These results indicate that the hypothalamic PNMT-IR terminal-like fibers originate in the ipsilateral medulla oblongata presumptive adrenaline-containing (Ad) neurons especially through ascending projections provided in majority by the longitudinal axon bundle.	Epinephrine	133-143	phenylethanolamine-N-methyltransferase	Rattus norvegicus	45-49
3662456-1	1987	Phenylethanolamine N-methyltransferase (PNMT) is the rate-limiting enzyme involved in the synthesis of epinephrine and a specific marker for epinephrine neurons.	Epinephrine	103-114	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
3662456-1	1987	Phenylethanolamine N-methyltransferase (PNMT) is the rate-limiting enzyme involved in the synthesis of epinephrine and a specific marker for epinephrine neurons.	Epinephrine	103-114	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
3662456-1	1987	Phenylethanolamine N-methyltransferase (PNMT) is the rate-limiting enzyme involved in the synthesis of epinephrine and a specific marker for epinephrine neurons.	Epinephrine	141-152	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
3662456-1	1987	Phenylethanolamine N-methyltransferase (PNMT) is the rate-limiting enzyme involved in the synthesis of epinephrine and a specific marker for epinephrine neurons.	Epinephrine	141-152	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
3632150-2	1987	We studied a patient with non-insulin-dependent diabetes mellitus who developed lactic acidosis and marked insulin resistance when treated with epinephrine after open heart surgery.	Epinephrine	144-155	insulin	Homo sapiens	30-37
3683592-6	1987	The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline.	Epinephrine	75-89	catechol-O-methyltransferase	Rattus norvegicus	5-9
3683592-6	1987	The kCOMT values for all four catecholamines, (-)-noradrenaline, dopamine, (-)-adrenaline and (+/-)-isoprenaline exhibit a range from 0.24 to 0.78 min-1; the metabolism of the catecholamines by the COMT differs: (-)-noradrenaline = dopamine less than (-)-adrenaline less than (+/-)-isoprenaline.	Epinephrine	251-265	catechol-O-methyltransferase	Rattus norvegicus	5-9
3302762-4	1987	Absence of the epinephrine response to insulin-induced hypoglycemia indicated that autonomic neuropathy was attended by severe adrenal medullary dysfunction.	Epinephrine	15-26	insulin	Homo sapiens	39-46
3683592-7	1987	The extraneuronal MAO activity was low for all three catecholamines, (-)-adrenaline, (-)-noradrenaline and dopamine (range of kMAO from 0.05 to 0.28 min-1) and declined in the order.	Epinephrine	69-83	monoamine oxidase A	Rattus norvegicus	18-21
2886078-2	1987	We hypothesized that activation of cardiac beta 2 receptors by endogenously released epinephrine and norepinephrine during surgical stress would add to the positive chronotropic response mediated by beta 1 stimulation.	Epinephrine	85-96	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	43-49
3038199-4	1987	The effect of epinephrine and glucagon was completely reciprocated by insulin and the action of insulin was totally erased by the other two.	Epinephrine	14-25	insulin	Homo sapiens	70-77
2886078-2	1987	We hypothesized that activation of cardiac beta 2 receptors by endogenously released epinephrine and norepinephrine during surgical stress would add to the positive chronotropic response mediated by beta 1 stimulation.	Epinephrine	85-96	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	199-205
2889157-4	1987	In this study, it has been shown that inhibition of phenylethanolamine-N-methyltransferase selectively decreases tissue levels in the hypothalamus and in vivo release of adrenaline, while monoamine oxidase inhibition and antagonism of alpha 2-adrenoceptors increases the release of both adrenaline and noradrenaline.	Epinephrine	170-180	phenylethanolamine N-methyltransferase	Homo sapiens	52-90
3297204-12	1987	Low concentrations of ADP and epinephrine, which induce fibrinogen receptors but little secretion, stimulated near-maximal PAC1 binding but little S12 binding.	Epinephrine	30-41	ADCYAP receptor type I	Homo sapiens	123-127
2884275-2	1987	Both NGF and CNTF enhanced chromaffin cell survival and partially prevented losses of adrenaline during the 4-day culture period in a dose-dependent manner.	Epinephrine	86-96	ciliary neurotrophic factor	Rattus norvegicus	13-17
2889157-4	1987	In this study, it has been shown that inhibition of phenylethanolamine-N-methyltransferase selectively decreases tissue levels in the hypothalamus and in vivo release of adrenaline, while monoamine oxidase inhibition and antagonism of alpha 2-adrenoceptors increases the release of both adrenaline and noradrenaline.	Epinephrine	287-297	phenylethanolamine N-methyltransferase	Homo sapiens	52-90
3616571-10	1987	These studies suggest that epinephrine- and ADP-induced platelet aggregation occurs via the exposure of fibrinogen receptors on shape-changed platelets.	Epinephrine	27-38	fibrinogen beta chain	Homo sapiens	104-114
3116982-4	1987	By contrast the response of arterial pressure, heart rate as well as the increase in blood glucose, plasma renin activity and the fall in plasma aldosterone and serum insulin levels induced by epinephrine were not affected by nitrendipine.	Epinephrine	193-204	insulin	Homo sapiens	167-174
3032590-1	1987	Treatment of isolated rat adipocytes with epinephrine or isoproterenol caused a time- and concentration-dependent increase in phospholipid methyltransferase (PLMT) activity that was blocked by propranolol and unaffected by phentolamine.	Epinephrine	42-53	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	126-156
3032590-1	1987	Treatment of isolated rat adipocytes with epinephrine or isoproterenol caused a time- and concentration-dependent increase in phospholipid methyltransferase (PLMT) activity that was blocked by propranolol and unaffected by phentolamine.	Epinephrine	42-53	phosphatidylethanolamine N-methyltransferase	Rattus norvegicus	158-162
3585599-0	1987	Exaggerated epinephrine responses to hypoglycemia in normal and insulin-dependent diabetic children.	Epinephrine	12-23	insulin	Homo sapiens	64-71
3034674-6	1987	Mixed ligand experiments showed that insulin stimulated GTPase activity in an additive fashion to GTPase activity stimulated by PGE1, due to Gs; by adrenaline (+ propranolol), due to the inhibitory guanine nucleotide regulatory protein, G1 and by vasopressin, which stimulates the putative "Gp", a G-protein suggested to control the stimulation of inositol phospholipid metabolism.	Epinephrine	148-158	insulin	Homo sapiens	37-44
3629541-5	1987	Pretreatment of the PRP with epinephrine increased the maximum transmittance during ADP aggregation, produced less-reversible aggregates (less subject to deaggregation by PGE1), and increased the aggregate flow resistance over the range of filtration pressures tested.	Epinephrine	29-40	complement component 4 binding protein alpha	Homo sapiens	20-23
3553949-5	1987	The hypoglycemia in the patients with well-controlled diabetes was associated with a lowering of the plasma threshold of glucose that triggered a release of epinephrine (less than 45 mg of glucose per deciliter, or 2.5 mmol per liter, vs. greater than 55 mg per deciliter, or 3.1 mmol per liter, in the other groups, P less than 0.01) as well as an enhanced sensitivity to the suppressive effects of insulin on hepatic glucose production.	Epinephrine	157-168	insulin	Homo sapiens	400-407
2883870-4	1987	Thus, beta 1 adrenoceptors may be considered as physiologically innervated receptors mediating responses to neuronally released norepinephrine, and beta 2 receptors as mediating responses to circulating catecholamines, particularly epinephrine.	Epinephrine	131-142	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	6-12
3553949-7	1987	We conclude that strict control of diabetes induces physiologic alterations (delayed release of epinephrine and persistent suppression of glucose production) that impair glucose counterregulation to doses of insulin in the therapeutic range.	Epinephrine	96-107	insulin	Homo sapiens	208-215
2437804-3	1987	Second, 3,5,3"-triiodo-L-thyronine (T3) and epinephrine, which increased cellular cAMP concentration but had no effect on cellular cGMP concentration, increased 2-DG uptake in the rat thymocyte.	Epinephrine	44-55	cathelicidin antimicrobial peptide	Rattus norvegicus	82-86
3617010-2	1987	In the presence of 1mM external calcium, epinephrine augmented the increase in cytoplasmic free calcium in response to collagen or thrombin, and this was inhibited by yohimbine.	Epinephrine	41-52	coagulation factor II, thrombin	Homo sapiens	131-139
3300845-3	1987	The electron microscopic localization of the adrenaline-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT) was examined in the rostral ventrolateral medulla (RVL) of adult rats.	Epinephrine	45-55	phenylethanolamine-N-methyltransferase	Rattus norvegicus	77-115
3300845-3	1987	The electron microscopic localization of the adrenaline-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT) was examined in the rostral ventrolateral medulla (RVL) of adult rats.	Epinephrine	45-55	phenylethanolamine-N-methyltransferase	Rattus norvegicus	117-121
2881942-0	1987	In vivo regulation of non-insulin-mediated and insulin-mediated glucose uptake by epinephrine.	Epinephrine	82-93	insulin	Homo sapiens	26-33
2881942-0	1987	In vivo regulation of non-insulin-mediated and insulin-mediated glucose uptake by epinephrine.	Epinephrine	82-93	insulin	Homo sapiens	47-54
3592145-8	1987	Subcutaneously administered adrenaline caused within 5 min a significant increase of plasma adrenaline level (from 1.0 +/- 0.2 to peak of 6.5 +/- 1.2 nM) which gradually decreased during 2 h. This mode of adrenaline administration increased the systolic blood pressure by a maximum of 11 +/- 3.5 mmHg, heart rate by 9 +/- 2.2 beats X min-1, tremor ratio by 4 +/- 0.6 and reduced the diastolic blood pressure by 18 +/- 4.7 mmHg.	Epinephrine	28-38	CD59 molecule (CD59 blood group)	Homo sapiens	334-339
2883556-7	1987	In the first experiment, epinephrine caused changes in insulin and glucagon levels at five minutes of plus 9 +/- 1 microU/mL and minus 1 +/- 3 pg/mL, respectively, and averaged plus 6 +/- 2 microU/mL and minus 9 +/- 5 pg/mL over the first hour.	Epinephrine	25-36	insulin	Canis lupus familiaris	55-62
2883556-9	1987	In the second experiment, intraportal replacement of insulin and glucagon during epinephrine infusion resulted in changes in insulin and glucagon levels at five minutes of plus 8 +/- 3 microU/mL and plus 2 +/- 2 pg/mL, respectively, and averaged plus 4 +/- 2 microU/mL and minus 7 +/- 6 pg/mL over the first hour.	Epinephrine	81-92	insulin	Canis lupus familiaris	53-60
2883556-9	1987	In the second experiment, intraportal replacement of insulin and glucagon during epinephrine infusion resulted in changes in insulin and glucagon levels at five minutes of plus 8 +/- 3 microU/mL and plus 2 +/- 2 pg/mL, respectively, and averaged plus 4 +/- 2 microU/mL and minus 7 +/- 6 pg/mL over the first hour.	Epinephrine	81-92	insulin	Canis lupus familiaris	125-132
3592145-8	1987	Subcutaneously administered adrenaline caused within 5 min a significant increase of plasma adrenaline level (from 1.0 +/- 0.2 to peak of 6.5 +/- 1.2 nM) which gradually decreased during 2 h. This mode of adrenaline administration increased the systolic blood pressure by a maximum of 11 +/- 3.5 mmHg, heart rate by 9 +/- 2.2 beats X min-1, tremor ratio by 4 +/- 0.6 and reduced the diastolic blood pressure by 18 +/- 4.7 mmHg.	Epinephrine	92-102	CD59 molecule (CD59 blood group)	Homo sapiens	334-339
3592145-8	1987	Subcutaneously administered adrenaline caused within 5 min a significant increase of plasma adrenaline level (from 1.0 +/- 0.2 to peak of 6.5 +/- 1.2 nM) which gradually decreased during 2 h. This mode of adrenaline administration increased the systolic blood pressure by a maximum of 11 +/- 3.5 mmHg, heart rate by 9 +/- 2.2 beats X min-1, tremor ratio by 4 +/- 0.6 and reduced the diastolic blood pressure by 18 +/- 4.7 mmHg.	Epinephrine	92-102	CD59 molecule (CD59 blood group)	Homo sapiens	334-339
2951052-6	1987	Plasmin not only stimulated platelet adenylate cyclase activity, but also suppressed the GTP-dependent alpha 2-adrenergic inhibition, thereby producing a five- to six-fold increased activity measured in the presence of adrenaline and GTP.	Epinephrine	219-229	plasminogen	Homo sapiens	0-7
3605543-1	1987	Reevaluation of current concepts in drug treatment during CPR was followed by some new recommendations concerning indication or dosage of drugs for CPR: While epinephrine remains the catecholamine of choice for cardiac resuscitation, application of buffer solutions should be performed with care.	Epinephrine	159-170	cytochrome p450 oxidoreductase	Homo sapiens	148-151
2951052-9	1987	Incubation of platelets with plasmin concentrations as low as 0.25 mg/ml resulted in an irreversible increase in membrane adenylate cyclase activity and suppression of the adrenaline-mediated inhibition of enzyme activity.	Epinephrine	172-182	plasminogen	Homo sapiens	29-36
3028889-7	1987	These results suggest that epinephrine is responsible for some, if not all, of the beta-TG release from the platelets during insulin-induced hypoglycemia.	Epinephrine	27-38	pro-platelet basic protein	Homo sapiens	83-90
3028889-7	1987	These results suggest that epinephrine is responsible for some, if not all, of the beta-TG release from the platelets during insulin-induced hypoglycemia.	Epinephrine	27-38	insulin	Homo sapiens	125-132
2885760-0	1987	Beta 2-adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium.	Epinephrine	58-68	adrenoceptor beta 2	Homo sapiens	0-19
3582518-6	1987	Theophylline increased the hypokalaemia, tachycardia and rise in systolic blood pressure which occurs in response to intravenous infusion of doses of L-adrenaline (0.02-0.06 microgram kg-1 min-1).	Epinephrine	150-162	CD59 molecule (CD59 blood group)	Homo sapiens	189-194
2951327-4	1987	The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/min) declined immediately during infusions of atrial natriuretic factor to a minimum of 49 +/- 5% of control (p less than 0.001) during 0.1 microgram/kg/min and to 63 +/- 5% (0.1 greater than p greater than 0.05) or 95 +/- 13% (not significant) during 0.3 or 1.0 microgram/kg/min.	Epinephrine	20-31	natriuretic peptide A	Canis lupus familiaris	106-131
2885760-5	1987	Selective blockade of beta 2-adrenoceptors without affecting beta 1-adrenoceptors still enabled both adrenaline and noradrenaline to cause maximum possible increases of contractile force through beta 1-adrenoceptors.	Epinephrine	101-111	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
2885760-5	1987	Selective blockade of beta 2-adrenoceptors without affecting beta 1-adrenoceptors still enabled both adrenaline and noradrenaline to cause maximum possible increases of contractile force through beta 1-adrenoceptors.	Epinephrine	101-111	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	195-201
2885760-7	1987	beta 2-adrenoceptors can mediate half of the maximum increase of contractile force elicited by low concentrations of adrenaline and also contribute to the increase of contractile force caused by high concentrations of noradrenaline.	Epinephrine	117-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-6
3582495-1	1987	PAF-acether (platelet-activating factor) and adrenaline synergized to induce aggregation of human platelets in whole blood and in platelet-rich plasma (PRP) irrespective of the use of citrate, of heparin or acid-citrate dextrose (ACD) as anticoagulants, whereas the partial adrenoceptor agonist clonidine imitated adrenaline in a limited number of cases and only when blood was collected in ACD.	Epinephrine	314-324	PCNA clamp associated factor	Homo sapiens	0-3
3582495-5	1987	The alpha 2-adrenoceptor antagonist yohimbine blocked the synergistic effects of adrenaline or clonidine associated to PAF-acether, reducing aggregation to that due to PAF-acether alone.	Epinephrine	81-91	PCNA clamp associated factor	Homo sapiens	119-122
3582495-5	1987	The alpha 2-adrenoceptor antagonist yohimbine blocked the synergistic effects of adrenaline or clonidine associated to PAF-acether, reducing aggregation to that due to PAF-acether alone.	Epinephrine	81-91	PCNA clamp associated factor	Homo sapiens	168-171
2822307-8	1987	Low dose adrenaline infusion (0.013 microgram/kg per min) does not cause ACTH or cortisol release, but appears to blunt the ACTH and cortisol rise caused by arginine vasopressin (0.14 pressor units/kg, i.m.	Epinephrine	9-19	arginine vasopressin	Homo sapiens	166-177
3567458-2	1987	Injection of 2 ng AVP into the NTS significantly increased MAP but not plasma catecholamine concentrations, while injection of 10 ng AVP significantly increased MAP and plasma noradrenaline and adrenaline levels.	Epinephrine	179-189	arginine vasopressin	Rattus norvegicus	133-136
3581871-3	1987	Epinephrine increases the phosphorylation of both 47 Kd and the intermediate filament protein, vimentin.	Epinephrine	0-11	desmin	Homo sapiens	64-93
3652476-7	1987	In patients with phaeochromocytoma, serum gamma enolase levels showed a significant positive correlation with urinary adrenaline levels (P less than 0.05), and after resection the elevated level of gamma enolase fell significantly (P less than 0.05) and returned to normal.	Epinephrine	118-128	enolase 2	Homo sapiens	42-55
3581871-3	1987	Epinephrine increases the phosphorylation of both 47 Kd and the intermediate filament protein, vimentin.	Epinephrine	0-11	vimentin	Homo sapiens	95-103
3587377-1	1987	The triazolodiazepines brotizolam, triazolam and alprazolam inhibited PAF-induced human platelet aggregation in vitro (IC50 = 0.54, 7.6 and 13.7 microM, respectively) but showed only a weak or no effect against other aggregating agents (ADP, adrenaline, collagen, serotonin, arachidonic acid).	Epinephrine	242-252	PCNA clamp associated factor	Homo sapiens	70-73
3545824-5	1987	Incremental addition of adrenaline (in the presence of 1 mU insulin/ml) caused a dramatic increase in the glycogenolytic rate (about 15-fold), but a much less marked inhibition of glycogen synthetic rate.	Epinephrine	24-34	insulin	Homo sapiens	60-67
2953085-0	1987	V1a-vasopressin specific receptors on human platelets: potentiation by ADP and epinephrine and evidence for homologous down-regulation.	Epinephrine	79-90	arginine vasopressin	Homo sapiens	4-15
2953085-3	1987	Aggregating effect of VP on human platelets was potentiated by both ADP and epinephrine.	Epinephrine	76-87	arginine vasopressin	Homo sapiens	22-24
3567248-1	1987	The effect of pH on the kinetic parameters (Kms, Vs) of the reaction of adrenaline and Fe(II) (More"s salt) oxidation by ceruloplasmin isolated from human donor blood was investigated.	Epinephrine	72-82	ceruloplasmin	Homo sapiens	121-134
3033838-1	1987	Recent evidence indicates that adrenaline and adenosine diphosphate each have separate stimulus-response pathways for induction of aggregation and inhibition of cAMP accumulation.	Epinephrine	31-41	cathelicidin antimicrobial peptide	Homo sapiens	161-165
3033838-3	1987	Our studies showed that the inhibitory effect of adrenaline and adenosine diphosphate on PGE1-induced increase of cAMP in the patients was not different from that of the controls both for adrenaline and adenosine diphosphate.	Epinephrine	49-59	cathelicidin antimicrobial peptide	Homo sapiens	114-118
3032649-4	1987	In addition, the inhibition of adenylate cyclase induced by alpha 2-receptor stimulation (100 microM adrenaline plus 100 microM propranolol) was completely suppressed in the cerebral cortical membranes by IAP pretreatment.	Epinephrine	101-111	Cd47 molecule	Rattus norvegicus	205-208
3800085-12	1987	"Early CPR" dogs were resuscitated in significantly less time once ACLS was started (29 versus 317 seconds), and required less electrical energy (100 versus 560 J), fewer countershocks (1.3 versus 4.0), and less epinephrine (0.1 versus 1.7 mg) than did "no CPR" animals.	Epinephrine	212-223	cytochrome p450 oxidoreductase	Canis lupus familiaris	7-11
3593215-2	1987	This study investigated the effects of sub-threshold concentrations of adrenaline (0.1-1 microM) on vasopressin (10 nM-1 microM)-induced platelet aggregation, ATP secretion, elevation of cytosolic free Ca2+ concentration ([Ca2+]i) and hydrolysis of inositol phospholipids, monitored as [32P]phosphatidic acid formation.	Epinephrine	71-81	arginine vasopressin	Homo sapiens	100-111
3593215-3	1987	Potentiation of vasopressin-induced aggregation and ATP secretion by adrenaline was accompanied by enhanced elevation of [Ca2+]i and [32P]phosphatidic acid formation.	Epinephrine	69-79	arginine vasopressin	Homo sapiens	16-27
3593215-4	1987	The stimulatory effects of adrenaline on vasopressin-induced platelet activation were mimicked by the combination of the Ca2+ ionophore, ionomycin, and the protein kinase C activator, phorbol 12-myristate 13-acetate, but not by either of these agents alone.	Epinephrine	27-37	arginine vasopressin	Homo sapiens	41-52
3567248-3	1987	For Fe(II) the effect of the ionizeable group was observed during substrate binding to the ceruloplasmin molecule, whereas in the course of the adrenaline oxidation reaction it manifests itself during catalytic interaction of the substrate with the enzyme.	Epinephrine	144-154	ceruloplasmin	Homo sapiens	91-104
3593215-5	1987	These results suggest that the potentiation of vasopressin-induced platelet activation by adrenaline is mediated via enhancement of inositol phospholipid hydrolysis and elevation of [Ca2+]i.	Epinephrine	90-100	arginine vasopressin	Homo sapiens	47-58
2883322-5	1987	The delayed afterdepolarizations or triggered action potentials induced by high-frequency electrical drive in the presence of epinephrine were also suppressed by somatostatin.	Epinephrine	126-137	somatostatin	Homo sapiens	162-174
3029657-5	1987	Agonist affinities (isoproterenol greater than epinephrine much greater than norepinephrine) were consistent with a predominance of beta-2 receptors; this predominance was confirmed by competition studies with the specific beta-2 receptor antagonist ICI 118-551 (75% beta-2, 25% beta-1).	Epinephrine	47-58	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	132-138
2956817-3	1987	Insulin releasing action of PMS was dose-, time- and temperature-related, occurred in the absence of glucose, and was inhibited by epinephrine, but not by mannoheptulose.	Epinephrine	131-142	insulin	Homo sapiens	0-7
2953252-6	1987	In heart-failure dogs, infusion of atrial natriuretic peptide increased plasma concentrations of norepinephrine and epinephrine.	Epinephrine	100-111	natriuretic peptide A	Canis lupus familiaris	35-61
3796219-1	1987	Dopamine-beta-hydroxylase catalyzes the beta-oxidation of dopamine to noradrenaline while phenylethanolamine-N-methyltransferase converts noradrenaline to adrenaline.	Epinephrine	73-83	dopamine beta-hydroxylase	Homo sapiens	0-25
2436407-2	1987	Immunoreactivity for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the conversion of norepinephrine to epinephrine, was present in the basal epidermis and upper dermis in 16 patients with psoriasis.	Epinephrine	112-123	phenylethanolamine N-methyltransferase	Homo sapiens	21-59
2436407-2	1987	Immunoreactivity for phenylethanolamine N-methyltransferase (PNMT), the enzyme involved in the conversion of norepinephrine to epinephrine, was present in the basal epidermis and upper dermis in 16 patients with psoriasis.	Epinephrine	112-123	phenylethanolamine N-methyltransferase	Homo sapiens	61-65
2829863-0	1987	Adrenaline and noradrenaline increase contractile force of human ventricle through both beta 1- and beta 2-adrenoceptors.	Epinephrine	0-10	adrenoceptor beta 1	Homo sapiens	88-120
3307308-8	1987	The plasma levels of free insulin, however, were elevated by approximately 20% (p less than 0.01) by metoprolol during hypoglycemia and the plasma concentrations of epinephrine, norepinephrine, growth hormone and cortisol were enhanced by the drug.	Epinephrine	165-176	insulin	Homo sapiens	26-33
3453041-7	1987	NaF, an activator of adenylate cyclase, like adrenaline, stimulated the incorporation of linoleic acid into ghost membrane phospholipids.	Epinephrine	45-55	C-X-C motif chemokine ligand 8	Homo sapiens	0-3
2829863-5	1987	Low adrenaline concentrations and high noradrenaline concentrations can increase contractile strength by up to 50% of maximum through beta 2.	Epinephrine	4-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	134-140
2435458-1	1987	The use of recombinant human interferon alpha subtype D (RIFN alpha D) was effective in reducing shedding of herpes simplex virus type-1 induced by iontophoresis of 6-hydroxydopamine and epinephrine.	Epinephrine	187-198	interferon alpha 1	Homo sapiens	29-39
3574778-1	1987	A highly sensitive and specific competitive beta-nerve growth factor radioimmunoassay (beta NGF-RIA) was utilized to determine the beta NGF levels in epinephrine-provoked saliva of adult male and female Swiss-Webster mice.	Epinephrine	150-161	nerve growth factor	Rattus norvegicus	44-68
3574778-1	1987	A highly sensitive and specific competitive beta-nerve growth factor radioimmunoassay (beta NGF-RIA) was utilized to determine the beta NGF levels in epinephrine-provoked saliva of adult male and female Swiss-Webster mice.	Epinephrine	150-161	nerve growth factor	Mus musculus	87-95
3574778-1	1987	A highly sensitive and specific competitive beta-nerve growth factor radioimmunoassay (beta NGF-RIA) was utilized to determine the beta NGF levels in epinephrine-provoked saliva of adult male and female Swiss-Webster mice.	Epinephrine	150-161	nerve growth factor	Mus musculus	131-139
3500834-1	1987	Prior research in this laboratory has shown that dexamethasone, aldosterone, and epinephrine interact in regulating the activity of ornithine decarboxylase (EC 4.1.1.17, ODC) in rat thymus and liver.	Epinephrine	81-92	ornithine decarboxylase 1	Rattus norvegicus	132-155
3500834-1	1987	Prior research in this laboratory has shown that dexamethasone, aldosterone, and epinephrine interact in regulating the activity of ornithine decarboxylase (EC 4.1.1.17, ODC) in rat thymus and liver.	Epinephrine	81-92	ornithine decarboxylase 1	Rattus norvegicus	170-173
2885202-4	1987	The beta 2-mediated depressor response to adrenaline infusion was abolished by propranolol and oxprenolol but persisted after atenolol.	Epinephrine	42-52	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	4-10
2946574-6	1987	Functional viability of this model was demonstrated by significant dose-related increases in ANF release in response to as little as 1 nM epinephrine.	Epinephrine	138-149	natriuretic peptide A	Rattus norvegicus	93-96
3316041-4	1987	Catecholamine excretion in urine (adrenaline + noradrenaline) on average was 252.3 +/- 77.9 ng min-1 during car racing and 121.9 +/- 37.3 ng min-1 during exhaustive ergometry (n = 10).	Epinephrine	34-44	CD59 molecule (CD59 blood group)	Homo sapiens	95-100
3297726-13	1987	It should be noted that the increase in insulin binding associated with contractile activity requires the presence of epinephrine.	Epinephrine	118-129	insulin	Homo sapiens	40-47
2455156-3	1987	injections of NPY in a low (7.5 pmol) or a high (1.25 nmol) dose increased adrenaline levels 4 h later in the caudal part of the dorsomedial medulla.	Epinephrine	75-85	neuropeptide Y	Homo sapiens	14-17
2485066-4	1987	There was a slight but significant increase in plasma noradrenaline as renin became inhibited: plasma adrenaline was unchanged.	Epinephrine	57-67	renin	Homo sapiens	71-76
2878972-7	1987	In addition, the abundance of adrenaline in this area at early gestational stages strongly suggests that, despite the paucity of tyrosine hydroxylase, phenylethanolamine N-methyltransferase is active in vivo and is utilizing a substrate other than noradrenaline.	Epinephrine	30-40	phenylethanolamine-N-methyltransferase	Rattus norvegicus	151-189
3029258-0	1987	Effect of adrenaline on basal and ovine corticotrophin-releasing factor-stimulated ACTH secretion in man.	Epinephrine	10-20	proopiomelanocortin	Homo sapiens	83-87
3029258-9	1987	The adrenaline infusions attenuated the ACTH and cortisol responses to oCRF-41 and were associated with a transient reduction of basal concentrations of both hormones.	Epinephrine	4-14	proopiomelanocortin	Homo sapiens	40-44
2878972-4	1987	Adrenaline concentrations correlate well with the activity of phenylethanolamine N-methyltransferase, showing a precocious development, whereas noradrenaline and 3,4-dihydroxyphenylethylamine (dopamine) concentrations are more closely related to the enhancement of tyrosine hydroxylase activity; at day 18 of gestation, for example, they are only 5 and 10%, respectively, of the adult values.	Epinephrine	0-10	phenylethanolamine-N-methyltransferase	Rattus norvegicus	62-100
3312570-7	1987	The increase in epinephrine in intact animals was correlated with a rise in NAT activity at 2 h. Moreover, pineal MEL content at 2, 3, and 4 h was significantly greater than control values.	Epinephrine	16-27	N-acetyltransferase 1	Rattus norvegicus	76-79
2882406-5	1987	Epinephrine and isoproterenol were also found to reduce heme in cytochrome c providing evidence that this mechanism could work well in an intact protein.	Epinephrine	0-11	cytochrome c, somatic	Homo sapiens	64-76
2879289-1	1987	Tyrosine hydroxylase [TyrOHase, tyrosine 3-monooxygenase, L-tyrosine, tetrahydropteridine:oxygen oxidoreductase (2-hydroxylating), EC 1.14.16.2] is the rate-limiting enzyme in the synthetic pathway of catecholamines and is expressed by neurons containing dopamine, norepinephrine, and epinephrine.	Epinephrine	268-279	tyrosine hydroxylase	Homo sapiens	32-56
2954167-3	1987	administration of 0.5 or 1.0 microgram kg-1 epinephrine applied 10 min after glucose on the activity of liver glycogen phosphorylase and glycogen synthase were studied one minute after the hormone injection in adult male rats which had fasted for 24 h. The administration of 0.5 microgram kg-1 epinephrine failed to influence the activity of either enzyme.	Epinephrine	44-55	glycogen phosphorylase L	Rattus norvegicus	104-132
3110846-0	1987	Naloxone and beta-endorphin alter the effects of post-training epinephrine on memory.	Epinephrine	63-74	pro-opiomelanocortin-alpha	Mus musculus	13-27
2879627-5	1986	In contrast, selective beta2 adrenoceptor blockade (ICI 118551, 100 micrograms X kg-1) prevented the adrenaline induced lowering of serum potassium concentration but not of ventricular vulnerability.	Epinephrine	101-111	beta-2 adrenergic receptor	Canis lupus familiaris	23-41
2963360-4	1987	Positive correlations were obtained between the two catecholamines and the platelet products in the control group and between adrenaline and both platelet factor 4 (r = 0.715, P less than 0.01) and beta-thromboglobulin (r = 0.547, P less than 0.05) in the acute myocardial infarction patients.	Epinephrine	126-136	pro-platelet basic protein	Homo sapiens	198-218
2948506-3	1986	Both alpha and gamma thrombin induced platelet aggregation which was potentiated in each case by epinephrine.	Epinephrine	97-108	coagulation factor II, thrombin	Homo sapiens	21-29
2948506-5	1986	The gamma thrombin-induced phosphorylation was slightly enhanced by epinephrine.	Epinephrine	68-79	coagulation factor II, thrombin	Homo sapiens	10-18
2948506-6	1986	In contrast, only alpha thrombin was capable of inducing significant arachidonic acid release and the small release induced by gamma thrombin was reduced by epinephrine.	Epinephrine	157-168	coagulation factor II, thrombin	Homo sapiens	133-141
3779100-0	1986	Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine.	Epinephrine	106-117	fibrinogen beta chain	Homo sapiens	14-24
3779100-4	1986	The current studies were designed to examine the effect of occupancy of platelet alpha 2-adrenergic receptors by epinephrine on the expression of fibrinogen receptors and on the aggregation of platelets.	Epinephrine	113-124	fibrinogen beta chain	Homo sapiens	146-156
3779100-5	1986	The ability of epinephrine to induce the expression of fibrinogen receptors was studied under two different conditions: acute stimulation (less than 1 min) and prolonged stimulation (50 to 90 min), the latter of which is associated with a reduction or "desensitization" of the platelet aggregation response.	Epinephrine	15-26	fibrinogen beta chain	Homo sapiens	55-65
3779100-7	1986	Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L).	Epinephrine	0-11	ADCYAP receptor type I	Homo sapiens	44-49
3779100-7	1986	Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L).	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	54-64
3779100-7	1986	Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L).	Epinephrine	132-143	ADCYAP receptor type I	Homo sapiens	44-49
3779100-7	1986	Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L).	Epinephrine	132-143	fibrinogen beta chain	Homo sapiens	54-64
3779100-15	1986	Ca-dependent reactions subsequent to fibrinogen binding may be necessary for maximal platelet aggregation and are impaired when platelets become desensitized to epinephrine.	Epinephrine	161-172	fibrinogen beta chain	Homo sapiens	37-47
2946569-2	1986	Since abnormalities in several of these functions are observed in diabetic subjects, we investigated the effects of streptozotocin-induced diabetes on the activity of the enzyme that converts norepinephrine to epinephrine [phenylethanolamine N-methyltransferase (PNMT)] in the brainstem and hypothalamus of the rat.	Epinephrine	195-206	phenylethanolamine-N-methyltransferase	Rattus norvegicus	223-261
3780129-2	1986	The peak mean (+/- SE) plasma epinephrine levels were 1.50 (+/- 0.61) and 4.22 (+/- 1.93) nmol/L 1 minute after each dose, respectively.	Epinephrine	30-41	immunoglobulin kappa variable 1-16	Homo sapiens	95-98
2881786-1	1986	The effects of direct adrenergic stimulation, achieved by 60-min adrenaline infusion (0.1-0.2 microgram kg-1 min-1), on thromboxane B2 (TxB2) production by platelets in whole blood ex vivo and on ADP-induced platelet aggregation were studied in seven healthy male volunteers.	Epinephrine	65-75	CD59 molecule (CD59 blood group)	Homo sapiens	109-114
3490977-10	1986	Enhancement by adrenaline of Ca2+ influx induced by U46619, thrombin and ADP has been shown by using Mn2+ as probe.	Epinephrine	15-25	coagulation factor II, thrombin	Homo sapiens	60-68
3023020-1	1986	Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone.	Epinephrine	29-40	angiotensinogen	Rattus norvegicus	166-180
3023020-1	1986	Depletion of hypothalamic norepinephrine (NE) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular (IVT) angiotensin II (AII) on LH release in ovariectomized rats pretreated with estradiol and progesterone.	Epinephrine	29-40	angiotensinogen	Rattus norvegicus	182-185
3490977-8	1986	Adrenaline, when added prior to non-saturating concentrations of U46619, thrombin, vasopressin or ADP, significantly enhances the increase in cytosolic [Ca2+] induced by these agonists in platelets suspended in media containing less than 0.1 microM or 1 mM Ca2+.	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	73-81
3490977-8	1986	Adrenaline, when added prior to non-saturating concentrations of U46619, thrombin, vasopressin or ADP, significantly enhances the increase in cytosolic [Ca2+] induced by these agonists in platelets suspended in media containing less than 0.1 microM or 1 mM Ca2+.	Epinephrine	0-10	arginine vasopressin	Homo sapiens	83-94
3490977-11	1986	Adrenaline also enhances the extent of [3H]5HT secretion induced by U46619, thrombin and vasopressin but fails to increase that induced by ADP in this aspirin-treated preparation.	Epinephrine	0-10	coagulation factor II, thrombin	Homo sapiens	76-84
3490977-11	1986	Adrenaline also enhances the extent of [3H]5HT secretion induced by U46619, thrombin and vasopressin but fails to increase that induced by ADP in this aspirin-treated preparation.	Epinephrine	0-10	arginine vasopressin	Homo sapiens	89-100
3475413-0	1986	Evidence that intracisternal injections of cholecystokinin-8 counteracts the cardiovascular effects of intracisternally injected adrenaline and neuropeptide Y in the alpha-chloralose anaesthetized rat.	Epinephrine	129-139	cholecystokinin	Rattus norvegicus	43-58
3302151-7	1986	However, a statistically significant increase in PNMT activity preceded and accompanied the second adrenaline elevation.	Epinephrine	99-109	phenylethanolamine-N-methyltransferase	Rattus norvegicus	49-53
3024170-5	1986	We propose that epinephrine, in promoting exposure of glycoprotein IIb/IIIa sites for fibrinogen binding, leads to a cytoplasmic alkalinization, which, in conjunction with local shifts in Ca2+, promotes low-level activation of phospholipase A.	Epinephrine	16-27	fibrinogen beta chain	Homo sapiens	86-96
2432203-10	1986	Furthermore, GAL-IR cell bodies coextensive with, but not coexisting in, TH-IR somata were seen in the C1 (epinephrine) horea in the ventrolateral medulla at the level of area postrema and in the most rostral aspects of the C1 group.	Epinephrine	107-118	galanin and GMAP prepropeptide	Rattus norvegicus	13-16
3025802-3	1986	Granulocyte membrane PEMT has Km for S-adenosylmethionine of 4.4 microM and specific activity 0.54 +/- 0.51 pmol/mg protein/15 min, is inhibited by S-adenosylhomocysteine, displays optimal activity at pH 8.0-9.5, and is stimulated by isoproterenol greater than epinephrine greater than norepinephrine, but not by prostaglandin E1, serum-treated zymosan, formyl-methionyl-leucyl-phenylalanine, or adenosine 3":5" cyclic monophosphate.	Epinephrine	261-272	phosphatidylethanolamine N-methyltransferase	Homo sapiens	21-25
3778900-3	1986	From all substances tested (isoproterenol, phenylephrine, adrenalin, histamine, angiotensin II, dansylcadaverine, propranolol) only isoproterenol and adrenalin slightly decreased total amount of phosphatidylcholine (PC).	Epinephrine	150-159	angiotensinogen	Homo sapiens	80-94
3466164-7	1986	These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine.	Epinephrine	129-140	aldo-keto reductase family 1 member A1	Homo sapiens	38-41
3466164-7	1986	These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine.	Epinephrine	129-140	aldo-keto reductase family 1 member A1	Homo sapiens	91-94
3030263-4	1986	The effect of 2.5 nM-VIP was almost totally counteracted (i.e. fructose 2,6-bisphosphate concentration was restored) by either adrenaline (1 microM) or the alpha 2-adrenergic agonist UK-14304 (1 microM); the alpha 2-agonist clonidine (1 microM) was less efficient, since the VIP effect was decreased by 72% only.	Epinephrine	127-137	vasoactive intestinal peptide	Homo sapiens	21-24
3540039-6	1986	Perikarya immunoreactive to the adrenaline-synthesizing enzyme PNMT were localized to a more restricted region of the VLM that extended from approximately the rostral aspect of the caudal third of the inferior olivary complex (level of the obex) to the caudal pole of the facial nucleus.	Epinephrine	32-42	phenylethanolamine-N-methyltransferase	Mus musculus	63-67
3030263-4	1986	The effect of 2.5 nM-VIP was almost totally counteracted (i.e. fructose 2,6-bisphosphate concentration was restored) by either adrenaline (1 microM) or the alpha 2-adrenergic agonist UK-14304 (1 microM); the alpha 2-agonist clonidine (1 microM) was less efficient, since the VIP effect was decreased by 72% only.	Epinephrine	127-137	vasoactive intestinal peptide	Homo sapiens	275-278
3533396-5	1986	Significant increments above baseline renin release were seen with the stimuli of adrenaline, noradrenaline and isoprenaline.	Epinephrine	82-92	renin	Rattus norvegicus	38-43
3536838-1	1986	Epinephrine responses to insulin-induced hypoglycemia have indicated that athletes have a higher adrenal medullary secretory capacity than untrained subjects.	Epinephrine	0-11	insulin	Homo sapiens	25-32
3817007-1	1986	Serum concentrations of calcium, magnesium, potassium and phosphate can be lowered experimentally by adrenaline, which also can stimulate the secretion of parathyroid hormone (PTH).	Epinephrine	101-111	parathyroid hormone	Homo sapiens	155-174
3817007-1	1986	Serum concentrations of calcium, magnesium, potassium and phosphate can be lowered experimentally by adrenaline, which also can stimulate the secretion of parathyroid hormone (PTH).	Epinephrine	101-111	parathyroid hormone	Homo sapiens	176-179
3491062-9	1986	IL-1 secretion by monocytes was increased up to 48 +/- 18% (P less than 0.01) by addition of physiological concentrations of epinephrine in vitro.	Epinephrine	125-136	interleukin 1 alpha	Homo sapiens	0-4
3491062-11	1986	Higher concentrations in the physiological range had no effect, and combinations of epinephrine and hydrocortisone suppressed IL-1 secretion.	Epinephrine	84-95	interleukin 1 alpha	Homo sapiens	126-130
2877082-6	1986	Butoxamine (5 X 10(-6) M), a beta-2 antagonist, but not atenolol (5 X 10(-6) M), a beta-1 antagonist, blocked the epinephrine-induced increase in cell-mediated cytotoxicity.	Epinephrine	114-125	hemoglobin, beta adult minor chain	Mus musculus	29-35
3752642-0	1986	Comparative effect of graded doses of epinephrine on regional brain blood flow during CPR in a swine model.	Epinephrine	38-49	cytochrome p450 oxidoreductase	Sus scrofa	86-89
2948294-3	1986	The second wave of aggregation of human PRP induced by epinephrine and platelet activating factor (PAF) was abolished by similar concentrations of the TXA2/PGH2 antagonists, whereas aggregation of canine PRP induced by ADP, serotonin plus epinephrine, or PAF was unaffected by these concentrations of the TXA2/PGH2 antagonists.	Epinephrine	55-66	complement component 4 binding protein alpha	Homo sapiens	40-43
2948294-3	1986	The second wave of aggregation of human PRP induced by epinephrine and platelet activating factor (PAF) was abolished by similar concentrations of the TXA2/PGH2 antagonists, whereas aggregation of canine PRP induced by ADP, serotonin plus epinephrine, or PAF was unaffected by these concentrations of the TXA2/PGH2 antagonists.	Epinephrine	239-250	complement component 4 binding protein alpha	Homo sapiens	40-43
2948294-4	1986	Epinephrine plus U46619-stimulated aggregation of canine PRP was abolished by RX 781094 (1 microM) but not by prazosin (10(-4) M), selective alpha 2- and alpha 1-adrenoceptor antagonists, respectively.	Epinephrine	0-11	complement component 4 binding protein alpha	Homo sapiens	57-60
3537023-1	1986	In this study, the distribution of neurons containing the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) was mapped in the medulla of the cat.	Epinephrine	58-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	89-127
3537023-1	1986	In this study, the distribution of neurons containing the adrenaline-synthesizing enzyme phenylethanolamine-N-methyltransferase (PNMT) was mapped in the medulla of the cat.	Epinephrine	58-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	129-133
3783085-2	1986	Various inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme which catalyses the conversion of noradrenaline to adrenaline, were administered to freely moving ovariectomized rats bearing an atrial cannula.	Epinephrine	117-127	phenylethanolamine-N-methyltransferase	Rattus norvegicus	22-60
3019887-2	1986	Norepinephrine, epinephrine, and phenylephrine stimulated tonin release, an effect that was inhibited by phentolamine but not by propranolol, whereas isoproterenol, carbachol, histamine, and serotonin did not stimulate tonin release.	Epinephrine	3-14	kallikrein 1-related peptidase C2	Rattus norvegicus	58-63
3783085-2	1986	Various inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme which catalyses the conversion of noradrenaline to adrenaline, were administered to freely moving ovariectomized rats bearing an atrial cannula.	Epinephrine	117-127	phenylethanolamine-N-methyltransferase	Rattus norvegicus	62-66
2875653-3	1986	The physiological beta 2-adrenergic receptor agonist, (-)-epinephrine (2.5 micrograms/kg), significantly increased the mean plasma concentrations of plasma LH and the amplitude of the LH pulses over a period of 70 min.	Epinephrine	54-69	adrenoceptor beta 2	Rattus norvegicus	18-44
3023761-5	1986	Norepinephrine and epinephrine inhibited the capacity of gamma interferon and lipopolysaccharide to stimulate IL-1 production from mouse peritoneal macrophages.	Epinephrine	3-14	interleukin 1 complex	Mus musculus	110-114
3023761-8	1986	This, coupled with the capacity of norepinephrine and epinephrine to enhance intracellular cAMP levels in macrophages, strongly suggested that the catecholamine-induced suppression of IL-1 production may be mediated by elevated intracellular cAMP levels.	Epinephrine	38-49	interleukin 1 complex	Mus musculus	184-188
2876904-3	1986	Further pretraining injections of a variety of adrenoceptor antagonists, including selective alpha 1-, alpha 2-, beta 1- and/or beta 2-adrenoceptor antagonists, attenuated the retention enhancing effects of posttraining epinephrine.	Epinephrine	220-231	adrenoceptor beta 1	Homo sapiens	93-147
3541907-9	1986	Glucagon, adrenaline and theophylline all produced a significant decline in the cell-surface immunodetectable lipoprotein lipase, which in the case examined (adrenaline) was partially additive with regard to the independent effect of cycloheximide.	Epinephrine	10-20	lipoprotein lipase	Homo sapiens	110-128
2879293-7	1986	noradrenaline (5 micrograms/kg), adrenaline (5 micrograms/kg) and phenylephrine (20 micrograms/kg) were markedly inhibited (60-75%) by benoxathian (100 micrograms/kg) whilst the pressor response to angiotensin II (0.05 micrograms/kg) was not reduced, but indeed slightly increased.	Epinephrine	3-13	angiotensinogen	Rattus norvegicus	198-212
2875902-1	1986	Oxytocin, vasopressin, melanostatin, bradykinin, LHRH-like peptide in different ways affected the spontaneous outflow and release of adrenaline and noradrenaline induced with central and peripheral nervous stimuli as well as with acetylcholine in the superfusate of the dog isolated inferior mesenteric ganglion.	Epinephrine	133-143	kininogen 1	Canis lupus familiaris	37-47
2942391-2	1986	An injection of synthetic human beta-endorphin (20 micrograms/kg BW) into a cephalic vein produced a significant rise in the portal concentration of dopamine, norepinephrine, and epinephrine.	Epinephrine	162-173	proopiomelanocortin	Homo sapiens	32-46
3530932-6	1986	The response of epinephrine to hypoglycemia was less pronounced after proinsulin (2P less than 0.05).	Epinephrine	16-27	insulin	Homo sapiens	70-80
3792275-3	1986	In patients with isolated ACTH deficiency, the 24-h urinary epinephrine level was significantly lower than the normal range.	Epinephrine	60-71	proopiomelanocortin	Homo sapiens	26-30
3015219-0	1986	Effects of adrenaline on the turnover of lipoprotein lipase in rat adipose tissue.	Epinephrine	11-21	lipoprotein lipase	Rattus norvegicus	41-59
3760482-8	1986	In newborn cells, only the highest concentration of 200 micrograms/ml ovine prolactin stimulated total catecholamine release at 6 h and 12 h, with significant increases of the three catecholamines at 12 h. In maternal cells, stimulation of catecholamine release was observed also with the highest concentration of prolactin tested (200 micrograms/ml) and after 12 h of incubation, when only the release of epinephrine was significantly enhanced by 324%.	Epinephrine	406-417	prolactin	Ovis aries	76-85
3017507-4	1986	The inhibitory effect of adrenaline, which was completely abolished by the pretreatment with IAP/NAD on forskolin/GTP-stimulated cyclase activity, was low in senescent rats compared to that in adult ones.	Epinephrine	25-35	Cd47 molecule	Rattus norvegicus	93-96
3015219-1	1986	The mechanisms by which adrenaline brings about a reduction in the lipoprotein lipase activity of adipose tissue in vitro were investigated.	Epinephrine	24-34	lipoprotein lipase	Rattus norvegicus	67-85
3015219-4	1986	On the other hand, the degradation of lipoprotein lipase, as measured by the loss of 3H-labelled enzyme protein during pulse-chase incubations of the epididymal fat bodies, was found to be significantly increased by the addition of adrenaline to the incubation medium at the start of the chase period.	Epinephrine	232-242	lipoprotein lipase	Rattus norvegicus	38-56
3015219-5	1986	It is concluded that adrenaline is able both to inhibit the synthesis of lipoprotein lipase and to stimulate its degradation.	Epinephrine	21-31	lipoprotein lipase	Rattus norvegicus	73-91
3755637-1	1986	The activity of the epinephrine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is 3- to 8-fold greater in rats of the Fischer 344 and Buffalo strains.	Epinephrine	20-31	phenylethanolamine-N-methyltransferase	Rattus norvegicus	52-90
3013859-2	1986	The present studies demonstrate that epinephrine and ADP stimulate a phosphatidylinositol-hydrolyzing phospholipase A2 activity in human platelets.	Epinephrine	37-48	phospholipase A2 group IB	Homo sapiens	102-118
3013859-8	1986	Taken together, the data suggest that epinephrine-provoked stimulation of phospholipase A2 activity may occur as a result of Ca2+ mobilization and a concomitant intraplatelet alkalinization resulting from accelerated Na+/H+ exchange.	Epinephrine	38-49	phospholipase A2 group IB	Homo sapiens	74-90
3755637-1	1986	The activity of the epinephrine biosynthetic enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) is 3- to 8-fold greater in rats of the Fischer 344 and Buffalo strains.	Epinephrine	20-31	phenylethanolamine-N-methyltransferase	Rattus norvegicus	92-96
3017797-14	1986	Thus, physiological adrenaline levels exert a pronounced insulin-antagonistic effect which is mediated by beta 2-receptor stimulation.	Epinephrine	20-30	insulin	Homo sapiens	57-64
3017797-2	1986	The insulin-antagonistic effect of adrenaline was studied in seven healthy subjects with the euglycaemic clamp technique using two insulin infusion rates (40 and 1200 mU X (m2)-1 min-1).	Epinephrine	35-45	insulin	Homo sapiens	4-11
3017797-14	1986	Thus, physiological adrenaline levels exert a pronounced insulin-antagonistic effect which is mediated by beta 2-receptor stimulation.	Epinephrine	20-30	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	106-112
3017797-3	1986	The adrenergic receptor mediating the adrenaline effect was characterized by concomitant infusion of propranolol (beta 1 + beta 2-antagonist) or metoprolol (beta 1-antagonist).	Epinephrine	38-48	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	114-120
3487767-0	1986	Neonatal hyperthyroidism impairs epinephrine-provoked secretion of nerve growth factor and epidermal growth factor in mouse saliva.	Epinephrine	33-44	nerve growth factor	Mus musculus	67-86
3017797-3	1986	The adrenergic receptor mediating the adrenaline effect was characterized by concomitant infusion of propranolol (beta 1 + beta 2-antagonist) or metoprolol (beta 1-antagonist).	Epinephrine	38-48	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	123-129
3017797-3	1986	The adrenergic receptor mediating the adrenaline effect was characterized by concomitant infusion of propranolol (beta 1 + beta 2-antagonist) or metoprolol (beta 1-antagonist).	Epinephrine	38-48	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	157-163
3017797-8	1986	Adrenaline antagonized this effect so that a significant glucose production was seen at the low but not at the high insulin level.	Epinephrine	0-10	insulin	Homo sapiens	116-123
3017797-9	1986	Propranolol, but not metoprolol, reversed this insulin-antagonistic effect of adrenaline.	Epinephrine	78-88	insulin	Homo sapiens	47-54
3017797-12	1986	Adrenaline induced a pronounced inhibition of glucose utilization at both insulin levels (78% and 37% inhibition respectively).	Epinephrine	0-10	insulin	Homo sapiens	74-81
3011124-6	1986	In hepatocytes from hypothyroid rats the preincubation with the activators of protein kinase C (vasopressin, angiotensin II, phorbol 12-myristate 13-acetate and epinephrine) reduced markedly the alpha 1-adrenergic responsiveness of the cells, whereas in identical experiments using cells from adrenalectomized rats only the preincubation with epinephrine diminished the responsiveness.	Epinephrine	343-354	arginine vasopressin	Rattus norvegicus	96-107
3763580-0	1986	[Cooperative effect of hydrocortisone, adrenaline and high-density lipoproteins in regulating the glucose-6-phosphate dehydrogenase activity of the liver].	Epinephrine	39-49	glucose-6-phosphate dehydrogenase	Rattus norvegicus	98-131
3763580-3	1986	It was shown that timely regulation of G-6-PDH by epinephrine and hydrocortisone which inhibits the activity of enzyme is manifested through the cAMP-dependent mechanism.	Epinephrine	50-61	glucose-6-phosphate dehydrogenase	Rattus norvegicus	39-46
3763580-4	1986	The cooperative effect of epinephrine, hydrocortisone and high-density lipoproteins that enables G-6-PDH activation was revealed.	Epinephrine	26-37	glucose-6-phosphate dehydrogenase	Rattus norvegicus	97-104
3015341-1	1986	The size of miniature end-plate potentials (m.e.p.p.s) and miniature end-plate currents (m.e.p.c.s) at frog neuromuscular junctions was increased by a factor of two or more following treatment with norepinephrine, epinephrine, a cAMP derivative, insulin or ACTH.	Epinephrine	201-212	insulin	Homo sapiens	246-253
3015341-1	1986	The size of miniature end-plate potentials (m.e.p.p.s) and miniature end-plate currents (m.e.p.c.s) at frog neuromuscular junctions was increased by a factor of two or more following treatment with norepinephrine, epinephrine, a cAMP derivative, insulin or ACTH.	Epinephrine	201-212	proopiomelanocortin	Homo sapiens	257-261
3011124-6	1986	In hepatocytes from hypothyroid rats the preincubation with the activators of protein kinase C (vasopressin, angiotensin II, phorbol 12-myristate 13-acetate and epinephrine) reduced markedly the alpha 1-adrenergic responsiveness of the cells, whereas in identical experiments using cells from adrenalectomized rats only the preincubation with epinephrine diminished the responsiveness.	Epinephrine	343-354	angiotensinogen	Rattus norvegicus	109-123
3521329-0	1986	Interaction between epinephrine and renal nerves in control of renin secretion rate.	Epinephrine	20-31	renin	Canis lupus familiaris	63-68
3709811-2	1986	Glucagon and epinephrine stimulated [U-14C]palmitate oxidation to ketone bodies by 60 and 25% as early as at 1 h. The stimulatory effects were almost totally prevented by the simultaneous presence of vasopressin, phorbol 12-tetradecanoate 13-acetate (TPA), or diacylglycerol (1-oleoyl-2-acetylglycerol).	Epinephrine	13-24	arginine vasopressin	Homo sapiens	200-211
3521329-1	1986	To determine whether the increase in renin secretion rate (RSR) produced by the beta 2-adrenoceptor agonist epinephrine was dependent on intact renal innervation, epinephrine (10 ng X kg-1 X min-1) was infused bilaterally into an innervated and a denervated kidney (ira) of the same anesthetized dog at spontaneous and reduced renal arterial pressure (decreases RAP, 100 mmHg).	Epinephrine	108-119	renin	Canis lupus familiaris	37-42
3521329-8	1986	Similarly, the beta 2-adrenoceptor antagonist ICI 118551 (0.005-0.25 microgram X kg-1 X min-1 ira) abolished the enhanced RSR response to decreases RAP produced by epinephrine.	Epinephrine	164-175	beta-2 adrenergic receptor	Canis lupus familiaris	15-34
2940358-8	1986	administration of norepinephrine with beta-endorphin blunted the plasma epinephrine response to i.c.	Epinephrine	21-32	proopiomelanocortin	Homo sapiens	38-52
3730434-2	1986	The steady-state kinetics of ceruloplasmin-catalyzed oxidation of organic substrates (pyrocatechine, adrenaline, rho-phenyldiamine) and Fe(II) was analyzed.	Epinephrine	101-111	ceruloplasmin	Homo sapiens	29-42
2942173-4	1986	Significant positive correlations appeared in the pre-eclamptic patients between venous BTG and arterial adrenaline (r = 0.82), arterial noradrenaline (r = 0.76) and venous adrenaline (r = 0.55).	Epinephrine	105-115	pro-platelet basic protein	Homo sapiens	88-91
3018381-1	1986	Ginsenosides Rb2, Rc and Rg1 suppressed corticotropin-induced, dibutyryl cyclic AMP-induced and epinephrine-induced lipolysis with the relative potencies Rb2 greater than Rc greater than Rg1.	Epinephrine	96-107	RB transcriptional corepressor like 2	Rattus norvegicus	13-16
3020115-5	1986	But, as in baseline conditions, a significant correlation was documented for the degree of adrenocortical activity and epinephrine excretion on the day of ACTH administration.	Epinephrine	119-130	proopiomelanocortin	Homo sapiens	155-159
2940358-17	1986	norepinephrine at a dose insufficient to reduce beta-endorphin-induced catecholamine secretion in vehicle-treated rats prevented beta-endorphin-induced epinephrine and norepinephrine secretion in rats whose brains had been depleted of norepinephrine by prior 6-OHDA treatment.	Epinephrine	3-14	proopiomelanocortin	Homo sapiens	129-143
3013661-2	1986	Although (-)adrenaline is a good substrate for the platelet enzyme MAO-B, enzymatic inhibition was not a prerequisite to quantify the specific binding of the radioligand to platelet membranes.	Epinephrine	12-22	monoamine oxidase B	Homo sapiens	67-72
3700383-3	1986	Treatment of the cells with either norepinephrine or epinephrine in the range of 0.05-0.2 mM for 24 h resulted in a 3-20-fold increase in NGF content in the medium of the L-M cells.	Epinephrine	38-49	nerve growth factor	Mus musculus	138-141
3700383-4	1986	The NGF of epinephrine-treated cell was identical to that of control cell.	Epinephrine	11-22	nerve growth factor	Mus musculus	4-7
3700383-7	1986	These results suggested that norepinephrine and epinephrine stimulated the de novo synthesis and secretion of NGF protein.	Epinephrine	32-43	nerve growth factor	Mus musculus	110-113
3024170-3	1986	Epinephrine evokes (i) an increased turnover of ester-linked arachidonic acid in aspirin treated platelets that is inhibited by ONO-RS-082, EDTA, yohimbine, or the absence of fibrinogen and (ii) a rapid cytoplasmic alkalinization that is inhibited partially by blockage of cyclooxygenase activity and completely by A2A9 or EIPA.	Epinephrine	0-11	fibrinogen beta chain	Homo sapiens	175-185
2870912-4	1986	Pertussis toxin produced an enhanced response to epinephrine (a mixed alpha-adrenergic and beta-adrenergic agonist) in cAMP production and in PTH secretion.	Epinephrine	49-60	parathyroid hormone	Bos taurus	142-145
3698518-4	1986	As observed with aggregation, 0.3 unit of thrombin/ml produced a more marked effect on release than ADP, noradrenaline and adrenaline being increased by 570% and 169% respectively.	Epinephrine	108-118	coagulation factor II, thrombin	Homo sapiens	42-50
2427705-14	1986	of quantal content induced by adrenaline was markedly suppressed by lowering temperature from 20-25 degrees C to 11-13 degrees C, and blocked by dibutyryl guanosine 3",5"-phosphate (dibutyryl cyclic GMP) (100 microM) consistently when applied together, but inconsistently when given after adrenaline.	Epinephrine	30-40	5'-nucleotidase, cytosolic II	Homo sapiens	199-202
3755510-3	1986	These cells correspond to the adrenergic subpopulation of chromaffin cells since they contain the epinephrine synthetic enzyme, phenylethanolamine N-methyltransferase.	Epinephrine	98-109	phenylethanolamine N-methyltransferase	Bos taurus	128-166
2871836-7	1986	A sharp post-surgery decline in plasma ANF was observed in control, phenylephrine and epinephrine-treated groups which was maintained during the observation period of five days.	Epinephrine	86-97	natriuretic peptide A	Rattus norvegicus	39-42
3523210-4	1986	Insulin, when administered together with adrenaline, restored hepatic glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities of diabetic animals to control values, without altering food consumption.	Epinephrine	41-51	glucose-6-phosphate dehydrogenase	Rattus norvegicus	70-103
3534807-6	1986	At 6 hours of incubation, VIP stimulated total catecholamine release from fetal adrenomedullary cells in a dose-dependent manner at concentrations ranging from 10(-8) to 10(-4) M. The release of norepinephrine and epinephrine, but not dopamine, was significantly enhanced.	Epinephrine	198-209	vasoactive intestinal peptide	Homo sapiens	26-29
3727471-0	1986	[Effect of adrenaline, hydrocortisone and serum HDL lipoproteins on the activity of multiple forms of glucose-6-phosphate dehydrogenase in the rat liver].	Epinephrine	11-21	glucose-6-phosphate dehydrogenase	Rattus norvegicus	102-135
3727471-1	1986	A decrease in activity of glucose-6-phosphate dehydrogenase (G6PD) in Wistar rat liver tissue, caused by stress, was realized via a mechanism, involving adrenaline and hydrocortisone as first messengers and cAMP as a second messenger.	Epinephrine	153-163	glucose-6-phosphate dehydrogenase	Rattus norvegicus	26-59
3727471-1	1986	A decrease in activity of glucose-6-phosphate dehydrogenase (G6PD) in Wistar rat liver tissue, caused by stress, was realized via a mechanism, involving adrenaline and hydrocortisone as first messengers and cAMP as a second messenger.	Epinephrine	153-163	glucose-6-phosphate dehydrogenase	Rattus norvegicus	61-65
2871746-1	1986	Comparative pharmacologic studies have indicated that the cardiac beta 2 adrenoceptors of vertebrate species are "adrenaline" receptors; i.e., the distribution of beta 2 receptors in the heart seems to be related to the amounts of adrenaline in the sympathetic nerves and in the circulation, and the beta 2 receptors seem to be stimulated mainly by adrenaline.	Epinephrine	114-124	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	66-72
2871746-1	1986	Comparative pharmacologic studies have indicated that the cardiac beta 2 adrenoceptors of vertebrate species are "adrenaline" receptors; i.e., the distribution of beta 2 receptors in the heart seems to be related to the amounts of adrenaline in the sympathetic nerves and in the circulation, and the beta 2 receptors seem to be stimulated mainly by adrenaline.	Epinephrine	114-124	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	163-169
2871746-1	1986	Comparative pharmacologic studies have indicated that the cardiac beta 2 adrenoceptors of vertebrate species are "adrenaline" receptors; i.e., the distribution of beta 2 receptors in the heart seems to be related to the amounts of adrenaline in the sympathetic nerves and in the circulation, and the beta 2 receptors seem to be stimulated mainly by adrenaline.	Epinephrine	114-124	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	163-169
2871746-1	1986	Comparative pharmacologic studies have indicated that the cardiac beta 2 adrenoceptors of vertebrate species are "adrenaline" receptors; i.e., the distribution of beta 2 receptors in the heart seems to be related to the amounts of adrenaline in the sympathetic nerves and in the circulation, and the beta 2 receptors seem to be stimulated mainly by adrenaline.	Epinephrine	231-241	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	66-72
2871746-1	1986	Comparative pharmacologic studies have indicated that the cardiac beta 2 adrenoceptors of vertebrate species are "adrenaline" receptors; i.e., the distribution of beta 2 receptors in the heart seems to be related to the amounts of adrenaline in the sympathetic nerves and in the circulation, and the beta 2 receptors seem to be stimulated mainly by adrenaline.	Epinephrine	231-241	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	163-169
2871746-1	1986	Comparative pharmacologic studies have indicated that the cardiac beta 2 adrenoceptors of vertebrate species are "adrenaline" receptors; i.e., the distribution of beta 2 receptors in the heart seems to be related to the amounts of adrenaline in the sympathetic nerves and in the circulation, and the beta 2 receptors seem to be stimulated mainly by adrenaline.	Epinephrine	231-241	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	163-169
2871746-6	1986	However, during acute stress situations the large amounts of released adrenaline are assumed to increase markedly both inotropy and chronotropy in the heart via beta 2 receptors.	Epinephrine	70-80	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	161-167
3017303-1	1986	We had previously demonstrated that the cyc- mutant of S49 wild-type lymphoma cells both desensitizes and undergoes a sequestration-internalization of the beta-receptor in response to short-term treatment with adrenaline.	Epinephrine	210-220	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	40-43
2871139-1	1986	We sought to characterize in detail neurons in rat retina that contain phenylethanolamine N-methyltransferase (PNMT), the epinephrine biosynthetic enzyme.	Epinephrine	122-133	phenylethanolamine-N-methyltransferase	Rattus norvegicus	71-109
3486086-4	1986	hCGRP (545 pmol/min) caused the diastolic pressure to fall from 64 +/- 5 to 55 +/- 7 mmHg (P less than 0.05), the heart rate to increase from 61 +/- 7 to 87 +/- 5 beats/min (P less than 0.05) and the skin temperature to increase from 33.7 +/- 0.9 to 34.9 +/- 0.5 degrees C. Plasma noradrenaline increased from 481 +/- 126 to 835 +/- 65 pg/ml (P less than 0.05) and plasma adrenaline from 57 +/- 17 to 82 +/- 12 pg/ml (P less than 0.05).	Epinephrine	284-294	calcitonin related polypeptide alpha	Homo sapiens	0-5
2871139-1	1986	We sought to characterize in detail neurons in rat retina that contain phenylethanolamine N-methyltransferase (PNMT), the epinephrine biosynthetic enzyme.	Epinephrine	122-133	phenylethanolamine-N-methyltransferase	Rattus norvegicus	111-115
3007905-0	1986	Epinephrine and norepinephrine stimulation of adenylate cyclase in bovine retina homogenate: evidence for interaction with the dopamine D1 receptor.	Epinephrine	0-11	dopamine receptor D1	Bos taurus	127-147
2874503-0	1986	The beta 1-adrenoceptor antagonist CGP 20712 A unmasks beta 2-adrenoceptors activated by (-)-adrenaline in rat sinoatrial node.	Epinephrine	89-103	adrenoceptor beta 1	Rattus norvegicus	4-23
2874503-2	1986	Concentration effect curves for (-)-adrenaline, but not for (-)-noradrenaline, became biphasic in the presence of the beta 1-adrenoceptor antagonist CGP 20712 A.	Epinephrine	32-46	adrenoceptor beta 1	Rattus norvegicus	118-137
2871553-7	1986	Epinephrine antagonized the TGF-beta-induced inhibition of DNA synthesis and squamous differentiation of NHBE cells.	Epinephrine	0-11	transforming growth factor beta 1	Homo sapiens	28-36
3005307-6	1986	The maximum turnover number for the alpha 2AR-mediated epinephrine-stimulated GTPase activity in Ni is similar to the maximal turnover numbers obtained for the beta-adrenergic receptor-mediated isoproterenol-stimulated GTPase activity in Ns and the rhodopsin-mediated light-stimulated GTPase activity in transducin (0.5-1.5 mol of Pi released per min per mol of nucleotide regulatory protein).	Epinephrine	55-66	rhodopsin	Homo sapiens	249-258
3005789-3	1986	It was observed that isoproterenol and epinephrine stimulated renin secretion and that clonidine decreased both basal and isoproterenol-stimulated renin secretion in the control group.	Epinephrine	39-50	renin	Rattus norvegicus	62-67
3012375-3	1986	Platelet rich plasma (PRP) was stimulated with ADP, collagen, sodium arachidonate, PAF, A23187 and epinephrine, while resuspended washed platelets (WP) were stimulated by thrombin.	Epinephrine	99-110	complement component 4 binding protein alpha	Homo sapiens	22-25
3006509-5	1986	After 50 min of insulin infusion, epinephrine levels increased 26-fold (P less than 0.05), norepinephrine and glucagon 3-fold (P less than 0.02), and cortisol 4-fold (P less than 0.01).	Epinephrine	34-45	insulin	Canis lupus familiaris	16-23
2422035-5	1986	Adrenaline, triiodothyronine, estradiol and progesterone were tested for their ability to stimulate alpha 2-macroglobulin synthesis.	Epinephrine	0-10	alpha-2-macroglobulin	Homo sapiens	100-121
3005093-1	1986	The response to insulin-induced hypoglycemia includes increased plasma levels of glucagon, epinephrine, norepinephrine, cortisol, and growth hormone.	Epinephrine	91-102	insulin	Canis lupus familiaris	16-23
3016131-8	1986	Lipoprotein lipase activity was decreased only by concentrations of epinephrine greater than those inducing maximal intracellular lipolysis, and the decrease in activity occurred about 30 min after the increase in glycerol release.	Epinephrine	68-79	lipoprotein lipase	Mus musculus	0-18
3005829-8	1986	In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine).	Epinephrine	274-289	protocadherin 8	Homo sapiens	100-104
3005829-8	1986	In competition studies, alpha-adrenergic antagonists and agonists inhibited the binding of 125I-rau-pAPC with a potency order consistent with an interaction at alpha 2-adrenergic receptors (rauwolscine greater than phentolamine greater than prazosin; clonidine greater than (-)-epinephrine greater than (-)-norepinephrine greater than dopamine greater than (+)-epinephrine).	Epinephrine	357-372	protocadherin 8	Homo sapiens	100-104
3003097-4	1986	The stimulation of inositide release by (-)-epinephrine (alpha 1), angiotensin II, or vasopressin in the presence of either 1 microM or 10 microM GTP gamma S correlates with the number of receptors present for each hormone.	Epinephrine	40-55	angiotensinogen	Rattus norvegicus	57-81
3083525-1	1986	The effects of low concentrations of epinephrine on the aggregation of macaque and human platelets by arachidonic acid (AA), collagen, and thrombin were studied.	Epinephrine	37-48	coagulation factor II, thrombin	Homo sapiens	139-147
3083525-4	1986	When near-threshold concentrations of collagen or thrombin were present in the medium, low concentrations of epinephrine (0.05 to 0.50 microM) potentiated the aggregation of macaque and human citrated platelets and macaque heparinized platelets.	Epinephrine	109-120	coagulation factor II, thrombin	Homo sapiens	50-58
2433918-2	1986	), of epinephrine evoke conspicuous consumption of circulatory rat kininogen (Kg), an effect not observed in animals pre-treated with either soybean trypsin inhibitor (SBTI, 10 mg/Kg, i.v.	Epinephrine	6-17	kininogen 2-like 1	Rattus norvegicus	67-76
3961734-4	1986	In other experiments ADP (1.0 microM) and epinephrine (2.0 microM) induced typical biphasic aggregation responses in human PRP.	Epinephrine	42-53	prion protein	Homo sapiens	123-126
2870098-6	1986	Following epinephrine depletion, adrenal tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) activities are increased for a few days in the control rats, corresponding to a transsynaptic induction.	Epinephrine	10-21	dopamine beta-hydroxylase	Rattus norvegicus	71-96
2870098-6	1986	Following epinephrine depletion, adrenal tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) activities are increased for a few days in the control rats, corresponding to a transsynaptic induction.	Epinephrine	10-21	dopamine beta-hydroxylase	Rattus norvegicus	98-101
2876589-4	1986	Insulin decreased blood glucose by 1.5 mmol/l and simultaneous suppression of glucagon resulted in a more pronounced hypoglycemia enhancing the adrenaline and cortisol responses.	Epinephrine	144-154	insulin	Homo sapiens	0-7
3080257-3	1986	In contrast, following TRH administration (4 mg/kg, iv), an increase in mean arterial pressure was associated with significant increases in plasma epinephrine, norepinephrine, and corticosterone.	Epinephrine	147-158	thyrotropin releasing hormone	Rattus norvegicus	23-26
3594004-0	1986	Effect of a selective inhibitor of epinephrine synthesis, SK&amp;F 64 139, on prolactin secretion in the rat.	Epinephrine	35-46	prolactin	Rattus norvegicus	78-87
3594004-5	1986	These results suggest that epinephrine may play a functional inhibitory role in prolactin secretion in the lactating and ovariectomized rat.	Epinephrine	27-38	prolactin	Rattus norvegicus	80-89
3004732-3	1986	Immunocytochemical staining for phenylethanolamine-N-methyltransferase revealed that both epinephrine and non-epinephrine cells concentrate 1,25-dihydroxyvitamin D3 in their nuclei.	Epinephrine	90-101	phenylethanolamine-N-methyltransferase	Mus musculus	32-70
3522922-1	1986	The ultrastructural localization of phenylethanolamine N-methyltransferase (PNMT), the enzyme used in the final step in the synthesis of adrenaline, was examined in the medial nuclei of the solitary tracts (m-NTS) and in the dorsal motor nuclei of the vagus.	Epinephrine	137-147	phenylethanolamine-N-methyltransferase	Rattus norvegicus	36-74
3709232-7	1986	Epinephrine had the opposite effect since chronic administration of dexamethasone or aldosterone with epinephrine resulted in control levels of ODC.	Epinephrine	0-11	ornithine decarboxylase 1	Rattus norvegicus	144-147
3709232-7	1986	Epinephrine had the opposite effect since chronic administration of dexamethasone or aldosterone with epinephrine resulted in control levels of ODC.	Epinephrine	102-113	ornithine decarboxylase 1	Rattus norvegicus	144-147
3721190-4	1986	Adrenaline and noradrenaline proved to be even more effective in increasing splenic ODC activity than isoproterenol.	Epinephrine	0-10	ornithine decarboxylase 1	Rattus norvegicus	84-87
2424845-8	1986	ALE seems therefore to recognize a new marker on IgE besides the known idiotypic, allotypic and isotypic ones.	Epinephrine	0-3	immunoglobulin heavy constant epsilon	Homo sapiens	49-52
3001183-4	1986	Norepinephrine and epinephrine blocked the capacity of recombinant interferon-gamma (IFN-gamma) to activate murine macrophages to a cytotoxic state capable of selectively killing HSV-infected cells.	Epinephrine	3-14	interferon gamma	Mus musculus	67-83
3001183-4	1986	Norepinephrine and epinephrine blocked the capacity of recombinant interferon-gamma (IFN-gamma) to activate murine macrophages to a cytotoxic state capable of selectively killing HSV-infected cells.	Epinephrine	3-14	interferon gamma	Mus musculus	85-94
3462329-8	1986	Norepinephrine, epinephrine and dopamine would stimulate GnRH secretion.	Epinephrine	3-14	gonadotropin releasing hormone 1	Homo sapiens	57-61
3522922-1	1986	The ultrastructural localization of phenylethanolamine N-methyltransferase (PNMT), the enzyme used in the final step in the synthesis of adrenaline, was examined in the medial nuclei of the solitary tracts (m-NTS) and in the dorsal motor nuclei of the vagus.	Epinephrine	137-147	phenylethanolamine-N-methyltransferase	Rattus norvegicus	76-80
3004519-1	1985	Epinephrine at concentrations varying between 3.3 and 12.5 nM had no effect on blood platelets when added alone, but augmented the in vitro platelet response to collagen and thrombin.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	174-182
2935879-2	1986	We have now found that this natriuretic effect of ANF is associated with a suppression of the initially elevated urinary excretion of norepinephrine and epinephrine and increase of the excretion of the main dopamine metabolite-dihydroxyphenylacetic acid as well as of the urinary dopamine to norepinephrine ratio.	Epinephrine	137-148	natriuretic peptide A	Rattus norvegicus	50-53
2868743-6	1985	In Study 2 adrenaline 0.05 micrograms kg-1 min-1 was infused for 80 min preceded by either idazoxan or vehicle.	Epinephrine	11-21	CD59 molecule (CD59 blood group)	Homo sapiens	43-48
2856791-2	1985	In the pre-eclamptic group, arterial adrenaline correlated with mean blood pressure (r = 0.90, P &lt; 0.001), heart rate (r = 0.78, P &lt; 0.01) and beta-thromboglobulin (r = 0.82, P &lt; 0.001), while in the normotensives adrenaline correlated only with beta-thromboglobulin (r = 0.76, P &lt; 0.01).	Epinephrine	37-47	pro-platelet basic protein	Homo sapiens	149-169
3007159-6	1985	When adenosine was prevented from accumulating in the incubation medium by inclusion of adenosine deaminase, low concentrations of epinephrine and norepinephrine preferentially exerted an antilipolytic action.	Epinephrine	131-142	adenosine deaminase	Homo sapiens	88-107
2871065-3	1985	In both preparations lysine-vasopressin (LVP) and epinephrine (EPI) stimulated ACTH secretion; prazosin (alpha-1 blocker) inhibited the EPI but not the LVP-mediated stimulation.	Epinephrine	50-61	proopiomelanocortin	Homo sapiens	79-83
2856711-3	1985	In contrast, low concentrations of ANG II (10(-11) mol/l) enhanced adrenaline-induced platelet aggregation but high concentrations (10(-7) mol/l) had an inhibitory effect.	Epinephrine	67-77	angiotensinogen	Homo sapiens	35-41
2856711-5	1985	The facilitatory effect of ANG II on adrenaline-induced platelet aggregation was abolished by pretreatment of platelets with flurbiprofen.	Epinephrine	37-47	angiotensinogen	Homo sapiens	27-33
2856711-6	1985	Thromboxane B2 synthesis by adrenaline-treated platelets was inhibited by ANG II.	Epinephrine	28-38	angiotensinogen	Homo sapiens	74-80
2908820-1	1985	Adrenaline may increase noradrenaline release and enhance sympathetic pressor effects through activation of pre-synaptic beta 2-adrenoceptors.	Epinephrine	0-10	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	121-127
3910726-4	1985	There was a slight but significant increase in plasma noradrenaline as renin became inhibited; plasma adrenaline was unchanged.	Epinephrine	57-67	renin	Homo sapiens	71-76
2856791-2	1985	In the pre-eclamptic group, arterial adrenaline correlated with mean blood pressure (r = 0.90, P &lt; 0.001), heart rate (r = 0.78, P &lt; 0.01) and beta-thromboglobulin (r = 0.82, P &lt; 0.001), while in the normotensives adrenaline correlated only with beta-thromboglobulin (r = 0.76, P &lt; 0.01).	Epinephrine	37-47	pro-platelet basic protein	Homo sapiens	255-275
2869468-4	1985	Following epinephrine depletion, the activities of adrenal tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) are transitorily increased in the 14 day-old controls; these increases are the consequence of transsynaptic inductions.	Epinephrine	10-21	dopamine beta-hydroxylase	Rattus norvegicus	89-114
3002669-3	1985	The infusion of adrenaline alone had no significant effect on insulin release while in the presence of idazoxan, insulin release was markedly stimulated by adrenaline.	Epinephrine	156-166	insulin	Homo sapiens	113-120
4079740-1	1985	Many experimental studies have utilized the activity of dopamine-beta-hydroxylase (DBH) as an index of sympathetic activity, since this enzyme is not submitted to uptake mechanisms or to enzymatic metabolism as are the circulating catecholamines norepinephrine (NE) and epinephrine (E).	Epinephrine	249-260	dopamine beta-hydroxylase	Homo sapiens	56-81
3909743-3	1985	Insulin (0.I and I nmol l-I) depressed lipolysis significantly at submaximal adrenaline stimulation but had no effect when lipolysis was stimulated maximally.	Epinephrine	77-87	insulin	Bos taurus	0-7
3002669-0	1985	Selective alpha 2 receptor blockade facilitates the insulin response to adrenaline but not to glucose in man.	Epinephrine	72-82	insulin	Homo sapiens	52-59
2869468-4	1985	Following epinephrine depletion, the activities of adrenal tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) are transitorily increased in the 14 day-old controls; these increases are the consequence of transsynaptic inductions.	Epinephrine	10-21	dopamine beta-hydroxylase	Rattus norvegicus	116-119
3840999-2	1985	The plasma levels of neuropeptide Y correlated better with the levels of noradrenaline than adrenaline, suggesting release of a neural origin.	Epinephrine	76-86	neuropeptide Y	Homo sapiens	21-35
3000362-2	1985	Adrenaline and isoproterenol both inhibited thrombin-induced phosphatidic acid formation in a dose-dependent manner.	Epinephrine	0-10	coagulation factor II	Rattus norvegicus	44-52
3002669-7	1985	Therefore the effect of adrenaline on insulin release is mediated by way of inhibitory alpha 2 adrenoceptors in the pancreas, while the release of insulin in response to glucose in a resting subject is independent of the alpha-adrenergic system.	Epinephrine	24-34	insulin	Homo sapiens	38-45
4089798-3	1985	Both aggregation and secretion induced with 0.03-0.3 U/ml of thrombin were markedly potentiated by epinephrine (0.5-4 microM), which alone was without effect.	Epinephrine	99-110	coagulation factor II, thrombin	Homo sapiens	61-69
3002868-2	1985	The data obtained show a difference in effects of calcitonin and parathyroid hormone upon the myocardium under conditions of an increased intracellular level of cAMP induced with theophylline and adrenaline.	Epinephrine	196-206	calcitonin related polypeptide alpha	Homo sapiens	50-60
3903538-0	1985	Reduction of central epinephrine concentrations is consistent with the continued occurrence of ovulation in rats treated with an inhibitor (LY 134046) of phenylethanolamine N-methyltransferase.	Epinephrine	21-32	phenylethanolamine-N-methyltransferase	Rattus norvegicus	154-192
4089798-4	1985	Addition of epinephrine before stimulation with thrombin resulted in a marked decrease in the concentration of thrombin required for half-maximal aggregation, without affecting the maximal aggregation response.	Epinephrine	12-23	coagulation factor II, thrombin	Homo sapiens	111-119
4089801-0	1985	Potentiation of adrenaline-induced platelet aggregation by angiotensin II.	Epinephrine	16-26	angiotensinogen	Homo sapiens	59-73
4089801-3	1985	In contrast, low concentrations of ANG II (10(-11) M) enhanced adrenaline-induced platelet aggregation but high concentrations (10(-7) M) had an inhibitory effect.	Epinephrine	63-73	angiotensinogen	Homo sapiens	35-41
4089801-5	1985	Pretreatment of platelets with flurbiprofen abolished this facilitatory effect of ANG II on adrenaline- but not on U44069-induced platelet aggregation.	Epinephrine	92-102	angiotensinogen	Homo sapiens	82-88
2863282-5	1985	Epinephrine and somatostatin both inhibited glucose-stimulated insulin release.	Epinephrine	0-11	insulin	Homo sapiens	63-70
2866610-2	1985	In washed platelets prelabeled with [3H]-serotonin, adrenaline and isoproterenol both inhibited, in a dose-dependent manner, the early thrombin-induced secretion of serotonin.	Epinephrine	52-62	coagulation factor II	Rattus norvegicus	135-143
2866610-4	1985	However, isoproterenol inhibited the thrombin-induced serotonin release to a much greater extent than the catecholamine, suggesting that the alpha 2-component of adrenaline might account for the difference observed between the two compounds.	Epinephrine	162-172	coagulation factor II	Rattus norvegicus	37-45
2931566-2	1985	Aggregation of citrated platelet-rich plasma (PRP) from 23 healthy volunteers induced by ADP, adrenaline, arachidonic acid, collagen, gamma-thrombin, the endoperoxide analogue U-44069, serotonin, the calcium ionophore A-23187 or platelet aggregating factor was measured after incubation of PRP with ANF for 3 minutes at concentrations of 4 X 10(-9), 4 X 10(-8) and 4 X 10(-7) M or vehicle as control.	Epinephrine	94-104	complement component 4 binding protein alpha	Homo sapiens	46-49
3908178-0	1985	Interaction between epinephrine, prostaglandin E, and met-enkephalin in the regulation of insulin release in man.	Epinephrine	20-31	insulin	Homo sapiens	90-97
3908178-6	1985	The inhibitory effect of epinephrine (15 ng/kg/min) upon glucose-induced insulin secretion was partially reversed by sodium salicylate, an inhibitor of endogenous prostaglandin synthesis, which increased but not normalized, either the acute insulin response and the glucose disappearance rates.	Epinephrine	25-36	insulin	Homo sapiens	73-80
2998890-2	1985	The lei-enkephalin analogue was shown to hinder the changes of these parameters induced with adrenaline.	Epinephrine	93-103	proenkephalin	Rattus norvegicus	8-18
2411729-7	1985	Platelets stimulated with ADP or epinephrine bind 10,000-15,000 125I-PAC-1 molecules/platelet while platelets stimulated with thrombin bind 20,000-25,000 molecules/platelet.	Epinephrine	33-44	ADCYAP receptor type I	Homo sapiens	69-74
2864433-2	1985	Spontaneous and evoked release of epinephrine was markedly reduced, when rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p., before decapitation.	Epinephrine	34-45	phenylethanolamine-N-methyltransferase	Rattus norvegicus	153-191
2864433-2	1985	Spontaneous and evoked release of epinephrine was markedly reduced, when rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p., before decapitation.	Epinephrine	232-243	phenylethanolamine-N-methyltransferase	Rattus norvegicus	153-191
3903555-3	1985	Strongly GR immunoreactive nerve cells were mainly found in the area of the noradrenaline, adrenaline and 5-hydroxytryptamine (5-HT) cell groups of the lower brain stem, and of the substantia gelatinosa of the nuc.	Epinephrine	79-89	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	9-11
4025856-3	1985	The mean +/- SEM plasma epinephrine concentration increased from a baseline of 42 +/- 7 pg/ml to a peak of 622 +/- 94 pg/ml 4 min after injection of epinephrine-containing anesthetic (P less than 0.001), whereas lidocaine alone increased the mean plasma value from 36 +/- 9 pg/ml (baseline) to only 69 +/- 16 pg/ml (not significantly different) at its peak.	Epinephrine	24-35	mucolipin TRP cation channel 1	Homo sapiens	121-125
2864362-1	1985	Neurons immunocytochemically labeled with the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase were mapped in the brain of rat pretreated with colchicine.	Epinephrine	46-56	phenylethanolamine-N-methyltransferase	Rattus norvegicus	77-115
4025856-3	1985	The mean +/- SEM plasma epinephrine concentration increased from a baseline of 42 +/- 7 pg/ml to a peak of 622 +/- 94 pg/ml 4 min after injection of epinephrine-containing anesthetic (P less than 0.001), whereas lidocaine alone increased the mean plasma value from 36 +/- 9 pg/ml (baseline) to only 69 +/- 16 pg/ml (not significantly different) at its peak.	Epinephrine	149-160	mucolipin TRP cation channel 1	Homo sapiens	121-125
2991399-10	1985	Restimulation of platelets with epinephrine also increased fibrinogen receptor exposure and restored the ability of platelets to aggregate, but was accompanied by barely detectable changes in quin-2 fluorescence similar to those observed with epinephrine-treated control platelets.	Epinephrine	32-43	fibrinogen beta chain	Homo sapiens	59-69
2862020-10	1985	The hormone affects solely epinephrine-induced glucagon release and its inhibitory action is partial and only observed at 10(-7) M. This suppressive effect of insulin is not attributable to variations in glucose handling but appears associated with the stimulatory effect of epinephrine.	Epinephrine	27-38	insulin	Homo sapiens	159-166
2862020-10	1985	The hormone affects solely epinephrine-induced glucagon release and its inhibitory action is partial and only observed at 10(-7) M. This suppressive effect of insulin is not attributable to variations in glucose handling but appears associated with the stimulatory effect of epinephrine.	Epinephrine	275-286	insulin	Homo sapiens	159-166
2413384-5	1985	Serotonin is localized in those medullary cells which contain phenylethanolamine-N-methyltransferase, an enzyme which is necessary for the synthesis of epinephrine.	Epinephrine	152-163	phenylethanolamine-N-methyltransferase	Rattus norvegicus	62-100
4088232-5	1985	Clinical studies revealed that adrenaline infusion test provoked significant gastrin responses to secrete acid secretions in duodenal ulcer patients.	Epinephrine	31-41	gastrin	Homo sapiens	77-84
4088235-7	1985	Both serum gastrin and plasma epinephrine began to increase 15 minutes after administration of insulin, peaked at the 45th minute, and decreased thereafter in control dogs and vagotomized dogs.	Epinephrine	30-41	insulin	Canis lupus familiaris	95-102
4088235-9	1985	In control dogs, the gastrin response was seen under continuous infusion of epinephrine (0.5 micrograms/kg/min).	Epinephrine	76-87	gastrin	Canis lupus familiaris	21-28
4088235-10	1985	Therefore, our results suggest that regardless of the presence or absence of vagal innervation, gastrin is released from G cells mainly due to epinephrine secreted from the adrenal medulla under insulin-induced hypoglycemia.	Epinephrine	143-154	gastrin	Canis lupus familiaris	96-103
4088235-10	1985	Therefore, our results suggest that regardless of the presence or absence of vagal innervation, gastrin is released from G cells mainly due to epinephrine secreted from the adrenal medulla under insulin-induced hypoglycemia.	Epinephrine	143-154	insulin	Canis lupus familiaris	195-202
3877338-10	1985	The studies provide evidence that IIB post-DDAVP vWF is bound to unstimulated platelets and that the interaction between vWF and platelets in type IIB vWD is different from ristocetin-induced as well as thrombin- and epinephrine-induced binding to platelets of normal vWF.	Epinephrine	217-228	von Willebrand factor	Homo sapiens	121-124
3877338-10	1985	The studies provide evidence that IIB post-DDAVP vWF is bound to unstimulated platelets and that the interaction between vWF and platelets in type IIB vWD is different from ristocetin-induced as well as thrombin- and epinephrine-induced binding to platelets of normal vWF.	Epinephrine	217-228	von Willebrand factor	Homo sapiens	121-124
2417354-4	1985	A strong positive correlation was observed between the levels of plasma beta TG and PF4 and between platelet aggregation to ADP and that to epinephrine in both the hypertensive and normotensive groups.	Epinephrine	140-151	pro-platelet basic protein	Homo sapiens	72-79
2863972-0	1985	Hypokalemia from beta 2-receptor stimulation by circulating epinephrine.	Epinephrine	60-71	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-23
4025969-0	1985	Beneficial effect of epinephrine infusion on cerebral and myocardial blood flows during CPR.	Epinephrine	21-32	cytochrome p450 oxidoreductase	Homo sapiens	88-91
4025969-2	1985	Our results with epinephrine infusion during CPR are consistent with this hypothesis.	Epinephrine	17-28	cytochrome p450 oxidoreductase	Homo sapiens	45-48
4025969-7	1985	Enhanced cerebral and myocardial perfusion occurred with epinephrine when either the conventional or simultaneous compression and ventilation (SCV) mode of CPR was employed in dogs.	Epinephrine	57-68	cytochrome p450 oxidoreductase	Canis lupus familiaris	156-159
4025969-8	1985	Similar selective perfusion was sustained for 50 minutes of SCV-CPR with epinephrine, even when the onset of CPR was delayed five minutes.	Epinephrine	73-84	cytochrome p450 oxidoreductase	Homo sapiens	64-67
4025969-10	1985	In an infant animal model of CPR using conventional CPR in piglets, epinephrine also was found to increase cerebral and myocardial blood flows.	Epinephrine	68-79	cytochrome p450 oxidoreductase	Homo sapiens	29-32
4025969-10	1985	In an infant animal model of CPR using conventional CPR in piglets, epinephrine also was found to increase cerebral and myocardial blood flows.	Epinephrine	68-79	cytochrome p450 oxidoreductase	Homo sapiens	52-55
4025969-11	1985	These results show that administration of epinephrine benefits different age groups of different species with different modes of CPR; that benefits occur even with delayed onset of CPR which is associated with additional anoxia and acidosis; and that epinephrine administration is particularly effective in sustaining cerebral and coronary perfusion during prolonged CPR.	Epinephrine	42-53	cytochrome p450 oxidoreductase	Homo sapiens	129-132
4025969-11	1985	These results show that administration of epinephrine benefits different age groups of different species with different modes of CPR; that benefits occur even with delayed onset of CPR which is associated with additional anoxia and acidosis; and that epinephrine administration is particularly effective in sustaining cerebral and coronary perfusion during prolonged CPR.	Epinephrine	42-53	cytochrome p450 oxidoreductase	Homo sapiens	181-184
4025969-11	1985	These results show that administration of epinephrine benefits different age groups of different species with different modes of CPR; that benefits occur even with delayed onset of CPR which is associated with additional anoxia and acidosis; and that epinephrine administration is particularly effective in sustaining cerebral and coronary perfusion during prolonged CPR.	Epinephrine	42-53	cytochrome p450 oxidoreductase	Homo sapiens	181-184
2990759-1	1985	Renal alpha 2-adrenoceptor stimulation by epinephrine infusion reverses cyclic adenosine monophosphate-mediated effects of vasopressin on sodium and water excretion.	Epinephrine	42-53	arginine vasopressin	Rattus norvegicus	123-134
2990759-3	1985	In the presence of alpha 1-adrenoceptor blockade with prazosin (30 nM) alpha 2-adrenoceptor stimulation with epinephrine reversed the cyclic adenosine monophosphate-mediated effects of vasopressin on sodium (P less than 0.05) and water (P less than 0.05) excretion.	Epinephrine	109-120	arginine vasopressin	Rattus norvegicus	185-196
4020433-8	1985	In micromolar glucocorticoid most of the cells resembled adrenal chromaffin or type II SIF cells: they displayed immunohistochemically detectable phenylethanolamine-N-methyltransferase (PNMT), synthesized and stored epinephrine, and contained large granular vesicles (100 to 300 nm).	Epinephrine	216-227	phenylethanolamine-N-methyltransferase	Rattus norvegicus	186-190
4020434-1	1985	Glucocorticoids are known to regulate the enzyme phenylethanolamine-N-methyltransferase (PNMT) in the adrenal medulla of the rat and are thereby thought to control the synthesis of epinephrine.	Epinephrine	181-192	phenylethanolamine-N-methyltransferase	Rattus norvegicus	49-87
4020434-1	1985	Glucocorticoids are known to regulate the enzyme phenylethanolamine-N-methyltransferase (PNMT) in the adrenal medulla of the rat and are thereby thought to control the synthesis of epinephrine.	Epinephrine	181-192	phenylethanolamine-N-methyltransferase	Rattus norvegicus	89-93
2991006-2	1985	Adrenaline, a beta-adrenergic receptor effector, forskolin, a direct adenylate cyclase activator and fluphenazine, a calmodulin inhibitor, all produced an increase in the intracellular level of cyclic AMP and a concomitant inhibition of lactose production.	Epinephrine	0-10	calmodulin 1	Rattus norvegicus	117-127
2411347-2	1985	Epinephrine concentrations were increased from 350 to 500% following chronic administration of LY 51641, a selective inhibitor of MAO type A.	Epinephrine	0-11	monoamine oxidase A	Rattus norvegicus	130-133
2411347-4	1985	The marked relative accumulation of epinephrine may be related to the efficacy of inhibitors of MAO type A in the treatment of depression.	Epinephrine	36-47	monoamine oxidase A	Rattus norvegicus	96-99
2990239-2	1985	We therefore examined the effect of alpha2-adrenoceptor stimulation with (-)-epinephrine (E) on cell cAMP content in the isolated proximal convoluted tubule (PCT), medullary and cortical thick ascending limb of Henle, and collecting tubule (MTAL, CTAL, MCT, and CCT, respectively).	Epinephrine	73-88	cathelicidin antimicrobial peptide	Rattus norvegicus	101-105
2861864-1	1985	A study was made of the effects of the neurotransmitters acetylcholine and adrenaline on proliferation of B lymphocytes of mice immunized with ovalbumin.	Epinephrine	75-85	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	143-152
2860926-4	1985	Theophylline, an inhibitor of phosphodiesterase, or forskolin, an activator of adenyl cyclase, increased diamine oxidase activity as does epinephrine or nephrectomy.	Epinephrine	138-149	amine oxidase, copper containing 1	Rattus norvegicus	105-120
4016033-6	1985	During pregnancy arterial plasma adrenaline levels were suppressed in the control group both when compared with the PIH group and postpartum values.	Epinephrine	33-43	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	116-119
3930975-2	1985	Isoprenaline, adrenaline and noradrenaline stimulated pepsinogen release in a dose-dependent manner with similar maximal effects, but isoprenaline was significantly more potent than the other two agonists.	Epinephrine	14-24	pepsin II-2/3	Oryctolagus cuniculus	54-64
3890959-10	1985	Thus, epinephrine at a high concentration stimulates hexose transport in the absence of adenosine deaminase (presence of adenosine) whereas it inhibits both basal and insulin-stimulated transport in the presence of adenosine deaminase (absence of adenosine).	Epinephrine	6-17	adenosine deaminase	Rattus norvegicus	88-107
3890959-10	1985	Thus, epinephrine at a high concentration stimulates hexose transport in the absence of adenosine deaminase (presence of adenosine) whereas it inhibits both basal and insulin-stimulated transport in the presence of adenosine deaminase (absence of adenosine).	Epinephrine	6-17	adenosine deaminase	Rattus norvegicus	215-234
2988346-7	1985	Alpha 2-Adrenoceptor stimulation with l-epinephrine (28 nM) reversed (P less than 0.05) the effects of vasopressin on water and sodium excretion.	Epinephrine	38-51	arginine vasopressin	Rattus norvegicus	103-114
3892214-0	1985	Effect of intravenous epinephrine infusion on plasma renin activity in adrenalectomized dogs.	Epinephrine	22-33	renin	Canis lupus familiaris	53-58
3892214-1	1985	Previous experiments have shown that circulating epinephrine stimulates renin secretin and increases plasma renin activity (PRA) when it is infused intravenously, but not when it is infused directly into the renal artery at similar infusion rates.	Epinephrine	49-60	renin	Canis lupus familiaris	72-77
3892214-1	1985	Previous experiments have shown that circulating epinephrine stimulates renin secretin and increases plasma renin activity (PRA) when it is infused intravenously, but not when it is infused directly into the renal artery at similar infusion rates.	Epinephrine	49-60	renin	Canis lupus familiaris	108-113
2408569-1	1985	L-Epinephrine, serotonin, and isoproterenol stimulate the incorporation of [14C]leucine into thrombin-induced clottable protein; this stimulation was abolished by actinomycin D.	Epinephrine	0-13	coagulation factor II	Rattus norvegicus	93-101
2862149-9	1985	The pro-hypertensive effect of adrenaline (0.5 mumol/kg, s.c.) was abolished by treatment with the beta 2-adrenoreceptor selective antagonist ICI 118551 (25 mg/kg/day, p.o.).	Epinephrine	31-41	adrenoceptor beta 2	Rattus norvegicus	99-120
2862149-14	1985	The results support the suggestion that a beta 2-adrenoreceptor-mediated facilitation of sympathetic neurotransmission may be involved in mediating the pro-hypertensive effects of circulating adrenaline in the SHR rat.	Epinephrine	192-202	adrenoceptor beta 2	Rattus norvegicus	42-63
2860336-7	1985	Inhalation of beta 2-agonists may be dangerous, especially in patients under stress--eg, during an acute asthmatic attack, when the plasma potassium concentration would already be subnormal as the result of raised circulating adrenaline levels.	Epinephrine	226-236	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	14-20
2410814-0	1985	Substance P given intrathecally at the spinal T9 level increases adrenal output of adrenaline and noradrenaline in the rat.	Epinephrine	83-93	tachykinin precursor 1	Homo sapiens	0-11
3990518-5	1985	Dexamethasone caused an increase in ornithine decarboxylase (ODC) activity within 1 to 2 hours after which the norepinephrine and epinephrine contents increased 16 hours after the peak of ODC activity in a dose dependent manner of dexamethasone in bovine adrenal medullary chromaffin cells in primary monolayer culture.	Epinephrine	114-125	ornithine decarboxylase	Bos taurus	36-59
3990518-5	1985	Dexamethasone caused an increase in ornithine decarboxylase (ODC) activity within 1 to 2 hours after which the norepinephrine and epinephrine contents increased 16 hours after the peak of ODC activity in a dose dependent manner of dexamethasone in bovine adrenal medullary chromaffin cells in primary monolayer culture.	Epinephrine	114-125	ornithine decarboxylase	Bos taurus	61-64
4041988-2	1985	An injection of ovine GH (6 or 100 micrograms/kg) into a cephalic vein produced in the hepatic portal circulation a transient, statistically significant rise of serotonin and a concomitant significant reduction in the concentration of dopamine, norepinephrine, and epinephrine.	Epinephrine	248-259	somatotropin	Canis lupus familiaris	22-24
2985451-5	1985	Moreover, the use of adrenaline and clonidine as alpha 2-adrenergic agonists reveals a relationship between the number of receptors and the intensity of the biological effect associated with their stimulation (inhibition of the VIP-induced cyclic AMP accumulation).	Epinephrine	21-31	vasoactive intestinal peptide	Homo sapiens	228-231
3022704-5	1985	When animals were tested 3 h after training, the post-training administration of ACTH and epinephrine caused an enhancement of test session performance; neither post-training beta-endorphin or naloxone, nor pretest ACTH, epinephrine, or beta-endorphin administration, had any effect in these animals.	Epinephrine	90-101	proopiomelanocortin	Homo sapiens	237-251
3884239-4	1985	Insulin release at 20 mmol of glucose/l was inhibited by adrenaline (0.1 mmol/l), and potentiated by theophylline (10 mmol/l) in the presence of 5 mmol of glucose/l, in islets cultured for 4 days.	Epinephrine	57-67	insulin	Homo sapiens	0-7
3900333-4	1985	The increase in blood sugar level by epinephrine and the conversion of [1-14C] pyruvate into blood glucose were distinctly suppressed with STA-protease as well as 5-methoxyindole-2-carboxylic acid (MICA), an inhibitor of gluconeogenesis.	Epinephrine	37-48	autosomal striping	Mus musculus	139-142
3993044-4	1985	In this connection it is noteworthy that among the "diabetogenic" hormones adrenaline exerts the strongest insulin-antagonistic effect and that hypertonic dehydration is associated with impairment of insulin action and of non-insulin-dependent hepatic glucose uptake (in vitro), while hypotonic rehydration reduces the elevated hepatic glucose production in dehydrated Type 1 diabetic patients.	Epinephrine	75-85	insulin	Homo sapiens	107-114
2986443-2	1985	The beta 1 receptors are activated primarily by norepinephrine released from the sympathetic nerves, the beta 2 by circulating epinephrine from the adrenal medulla.	Epinephrine	51-62	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	4-10
2409480-4	1985	The presence of PNMT-immunoreactive material in a neuron implies that epinephrine is a probable neurotransmitter for such a cell.	Epinephrine	70-81	phenylethanolamine N-methyltransferase	Homo sapiens	16-20
3885957-0	1985	Effect of epinephrine and norepinephrine on immuno-reactive insulin secretion from isolated islets of Langerhans.	Epinephrine	10-21	insulin	Homo sapiens	60-67
3873238-1	1985	At maximally effective concentrations, vasopressin (10(-7) M) increased myo-inositol trisphosphate (IP3) in isolated rat hepatocytes by 100% at 3 s and 150% at 6 s, while adrenaline (epinephrine) (10(-5) M) produced a 17% increase at 3 s and a 30% increase at 6 s. These increases were maintained for at least 10 min.	Epinephrine	183-194	arginine vasopressin	Rattus norvegicus	39-50
3885957-5	1985	This clearly suggests that epinephrine and norepinephrine inhibit insulin release via alpha-adrenergic pathway.	Epinephrine	27-38	insulin	Homo sapiens	66-73
2989015-2	1985	During insulin deprivation plasma epinephrine and norepinephrine increased slightly (from 107 +/- 10 ng/L to 173 +/- 6 ng/L and from 307 +/- 37 ng/L to 518 +/- 77/ng/L respectively (p less than 0.05), cortisol decreased physiologically, but growth hormone and glucagon were not significantly modified.	Epinephrine	34-45	insulin	Homo sapiens	7-14
3971933-3	1985	When the sympathomimetics norepinephrine, epinephrine, and isoproterenol were added to the medium, androgen production in response to hCG was enhanced by 100-300%.	Epinephrine	29-40	hypertrichosis 2 (generalised, congenital)	Homo sapiens	134-137
4008144-10	1985	Lactate levels (+30%) as well as noradrenaline and adrenaline responses (+60%-90%) were higher in the cumulative experiment (test 1) at work loads corresponding to 70%-80% of the oxygen uptake capacity as compared to the noncumulative testing procedure (test 2).	Epinephrine	36-46	serine protease 21	Homo sapiens	125-131
2982420-10	1985	In the experiments using arachidonic acid or phospholipase A2, the addition of indomethacin blocked the adrenaline oxidation.	Epinephrine	104-114	LOC104974671	Bos taurus	45-61
3998462-1	1985	The effects of sinoaortic denervation on arterial blood pressure and central activity of phenylethanolamine-N-methyl transferase (PNMT, the last enzyme in adrenaline biosynthesis), were compared in normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP).	Epinephrine	155-165	phenylethanolamine-N-methyltransferase	Rattus norvegicus	89-128
3973827-8	1985	Significant elevations of arterial plasma norepinephrine, epinephrine and dopamine occurred after T-2, with metabolic acidosis, hypocarbia and hyperoxemia in both conscious rats and guinea pigs.	Epinephrine	45-56	brachyury 2	Rattus norvegicus	98-101
2987667-1	1985	A rapid and transient decrease in 2"-phosphodiesterase activity in NIH 3T3 mouse cells was observed after adrenaline addition.	Epinephrine	106-116	phosphodiesterase 12	Mus musculus	34-54
2983686-7	1985	Also, adrenaline provoked a stimulated induction of PEPCK in hyperthyroid rats compared with hypothyroid rats.	Epinephrine	6-16	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	52-57
2983686-8	1985	To summarize, our data indicate that the primary action of thyroid hormones on the synthesis of hepatic cytosolic PEPCK is to accelerate the cyclic AMP- or adrenaline-induction of the enzyme, acting primarily at a pretranslational level.	Epinephrine	156-166	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	114-119
3885079-1	1985	Adrenaline neurons in human brain were demonstrated by immunohistochemistry using antibody to phenylethanolamine-N-methyltransferase (PNMT), the final enzyme in the pathway of adrenaline synthesis, using fixed frozen sections and a highly sensitive free floating technique which utilizes metallization.	Epinephrine	0-10	phenylethanolamine N-methyltransferase	Homo sapiens	94-132
3885079-1	1985	Adrenaline neurons in human brain were demonstrated by immunohistochemistry using antibody to phenylethanolamine-N-methyltransferase (PNMT), the final enzyme in the pathway of adrenaline synthesis, using fixed frozen sections and a highly sensitive free floating technique which utilizes metallization.	Epinephrine	0-10	phenylethanolamine N-methyltransferase	Homo sapiens	134-138
3885079-1	1985	Adrenaline neurons in human brain were demonstrated by immunohistochemistry using antibody to phenylethanolamine-N-methyltransferase (PNMT), the final enzyme in the pathway of adrenaline synthesis, using fixed frozen sections and a highly sensitive free floating technique which utilizes metallization.	Epinephrine	176-186	phenylethanolamine N-methyltransferase	Homo sapiens	94-132
3885079-1	1985	Adrenaline neurons in human brain were demonstrated by immunohistochemistry using antibody to phenylethanolamine-N-methyltransferase (PNMT), the final enzyme in the pathway of adrenaline synthesis, using fixed frozen sections and a highly sensitive free floating technique which utilizes metallization.	Epinephrine	176-186	phenylethanolamine N-methyltransferase	Homo sapiens	134-138
3884075-3	1985	Before these treatments CS2 exposed rats had more dopamine and less adrenaline in their adrenals than controls, and CS2 exposure also elevated the adrenal synthesis of catecholamines.	Epinephrine	68-78	calsyntenin 2	Rattus norvegicus	24-27
3917908-6	1985	The physiological relevance of these differentiative actions of insulin is suggested by insulin"s ability to significantly enhance the stimulatory effects of FSH, LH, epinephrine, prostaglandin E2, and cAMP effectors, cholera toxin and 8-bromo-cAMP.	Epinephrine	167-178	insulin	Sus scrofa	64-71
2983040-3	1985	The rank-order of potency of several adrenergic agonists in potentiating the effect of VIP on cAMP levels is the following: epinephrine greater than NE greater than phenylephrine much greater than clonidine, with EC50 of 2.2, 5, and 10 microM, respectively (clonidine being only marginally effective).	Epinephrine	124-135	vasoactive intestinal polypeptide	Mus musculus	87-90
2982014-10	1985	When rats were pretreated with 2,3-dichloro-alpha-methylbenzylamine, an inhibitor of phenylethanolamine N-methyltransferase, the enzyme catalyzing the formation of epinephrine from norepinephrine, 80 mg/kg i.p.	Epinephrine	164-175	phenylethanolamine-N-methyltransferase	Rattus norvegicus	85-123
3998462-1	1985	The effects of sinoaortic denervation on arterial blood pressure and central activity of phenylethanolamine-N-methyl transferase (PNMT, the last enzyme in adrenaline biosynthesis), were compared in normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR) and stroke-prone spontaneously hypertensive rats (SHR-SP).	Epinephrine	155-165	phenylethanolamine-N-methyltransferase	Rattus norvegicus	130-134
3901991-7	1985	At the start and immediately after withdrawal of adrenaline infusion plasma insulin was increased approximately twofold.	Epinephrine	49-59	LOC105613195	Ovis aries	76-83
3917939-3	1985	When liver mitochondria were prepared from rats treated with adrenaline, and then incubated in Na-free media containing EGTA, both PDH and OGDH activities were found to be enhanced.	Epinephrine	61-71	oxoglutarate dehydrogenase	Rattus norvegicus	139-143
2984004-7	1985	When tested on intact cells, epinephrine, norepinephrine and clonidine were found to counteract, in a dose-dependent manner, the increase of cyclic AMP triggered by vasoactive intestinal peptide (VIP).	Epinephrine	29-40	vasoactive intestinal peptide	Homo sapiens	196-199
2984004-9	1985	The physiological amines were the most efficient agonists: both epinephrine and norepinephrine inhibited VIP-induced cyclic AMP accumulation by 50-55% with KD values of 50 nM and 300 nM respectively.	Epinephrine	64-75	vasoactive intestinal peptide	Homo sapiens	105-108
3929669-14	1985	We have demonstrated that, in amphibians, dopamine inhibits alpha-MSH secretion through D2-type dopaminergic receptors whereas norepinephrine and (or) epinephrine stimulate alpha-MSH secretion via beta-adrenergic receptors.	Epinephrine	130-141	proopiomelanocortin	Homo sapiens	173-182
2983802-0	1985	Muscarine and luteinizing hormone releasing hormone attenuate adrenaline induced hyperpolarization in amphibian sympathetic ganglia.	Epinephrine	62-72	gonadotropin releasing hormone 1	Homo sapiens	14-51
3902270-5	1985	Plasma insulin concentrations were uniformly low, especially with respect to the hyperglycemia, in patients with high plasma epinephrine concentrations.	Epinephrine	125-136	insulin	Homo sapiens	7-14
2988827-3	1985	Compared to pre-infusion control values, ACTH raised mean arterial pressure by 14.9 +/- 2.2 mmHg by the 4th day of infusion, adrenaline infused alone had no effect (-0.2 +/- 3.9 mmHg), and ACTH and adrenaline infused together raised pressure 13.1 +/- 3.2 mmHg (not significantly different to ACTH alone).	Epinephrine	198-208	proopiomelanocortin	Canis lupus familiaris	41-45
2994916-4	1985	The increases in alpha 2- and beta 2-adrenoceptor densities were accompanied by enhanced responsiveness to adrenergic stimulation: in platelets adrenaline-induced aggregation--via alpha 2-adrenoceptor stimulation--was exaggerated, and in lymphocytes isoprenaline produced significantly greater increases in the intracellular level of cyclic AMP.	Epinephrine	144-154	adrenoceptor beta 2	Homo sapiens	17-49
3910304-1	1985	The role of circulating epinephrine in the regulation of renin release was studied in unanesthetized rats with glucocorticoid-induced hypertension.	Epinephrine	24-35	renin	Rattus norvegicus	57-62
3910304-7	1985	Plasma renin activity was significantly higher in epinephrine-deficient than in sham-operated rats.	Epinephrine	50-61	renin	Rattus norvegicus	7-12
2862033-1	1985	During infusion with adrenaline in healthy subjects there was a more than 50% reduction in serum myoglobin concentrations.	Epinephrine	21-31	myoglobin	Homo sapiens	97-106
3896628-4	1985	EGF and NGF also inhibited epinephrine-induced lipolysis.	Epinephrine	27-38	epidermal growth factor	Rattus norvegicus	0-3
2865053-5	1985	Both the antilipogenic and lipolytic effects of epinephrine were partially blocked by phentolamine (alpha 1 = alpha 2 antagonist) or propranolol (beta 1 = beta 2 antagonist), but completely inhibited by phentolamine and propranolol administered together.	Epinephrine	48-59	asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase homolog (S. cerevisiae)	Gallus gallus	100-117
4044301-2	1985	In this study we have used electron microscopic immunocytochemical methods to study the subcellular distribution of serotonin and the enzyme responsible for epinephrine biosynthesis, phenylethanolamine-N-methyltransferase (PNMT).	Epinephrine	157-168	phenylethanolamine-N-methyltransferase	Rattus norvegicus	183-221
4044301-9	1985	The co-localization of serotonin and PNMT in the same vesicle is suggestive of a capacity for co-release of serotonin and epinephrine by the adrenal medulla.	Epinephrine	122-133	phenylethanolamine-N-methyltransferase	Rattus norvegicus	37-41
2414575-4	1985	The higher sensitivity to adrenaline for thrombin-induced calcium increases in platelets of hypertensive patients indicates potentiation of calcium influx (and mobilization from intracellular stores) by adrenaline, a mechanism that is mediated by alpha 2-adrenoceptors.	Epinephrine	26-36	coagulation factor II, thrombin	Homo sapiens	41-49
2997065-2	1985	Kadsurenone inhibits the specific binding of 3H-PAF to a receptor preparation from rabbit platelet membrane in a competitive and reversible manner, its Ki being 3.88 X 10(-8) M. It inhibits the aggregation of rabbit platelets in plasma induced by PAF with a pA2 of 6.28, but not those induced by arachidonic acid, epinephrine, ADP or A-23187.	Epinephrine	314-325	PCNA clamp associated factor	Rattus norvegicus	48-51
2409391-6	1985	Those that increase transmitter release include epinephrine (acting on beta 2-adrenoceptors) and angiotensin II.	Epinephrine	48-59	angiotensinogen	Homo sapiens	71-111
2414581-3	1985	Concomitantly with receptor densities, functional responses to adrenergic stimulation were exaggerated in essential hypertension: in platelets, the aggregatory response to (-)-adrenaline (via alpha 2-adrenoceptor stimulation) was enhanced; in lymphocytes, the cyclic AMP response to (-)-isoprenaline (via beta 2-adrenoceptor stimulation) was elevated.	Epinephrine	172-186	adrenoceptor beta 2	Homo sapiens	305-324
2414575-4	1985	The higher sensitivity to adrenaline for thrombin-induced calcium increases in platelets of hypertensive patients indicates potentiation of calcium influx (and mobilization from intracellular stores) by adrenaline, a mechanism that is mediated by alpha 2-adrenoceptors.	Epinephrine	203-213	coagulation factor II, thrombin	Homo sapiens	41-49
4094442-2	1985	In conjunction with low concentrations of PAF-acether, adrenaline induces aggregation which is not susceptible to blockade by aspirin.	Epinephrine	55-65	PCNA clamp associated factor	Homo sapiens	42-45
2984267-0	1985	Epinephrine-induced sequestration of the beta-adrenergic receptor in cultured S49 WT and cyc- lymphoma cells.	Epinephrine	0-11	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	89-92
2984267-1	1985	Pretreatment of either intact wild type S49 lymphoma cells (WT) or the uncoupled variants, cyc-, H21a, or UNC with epinephrine results in the redistribution of 20-30% of the beta-adrenergic receptors into a light vesicle fraction in sucrose gradients.	Epinephrine	115-126	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	91-94
2981299-6	1985	Pretreatment did not affect ACTH content nor did it alter the ability of epinephrine or forskolin to stimulate ACTH release.	Epinephrine	73-84	pro-opiomelanocortin-alpha	Mus musculus	111-115
2860247-3	1985	The longlasting signal generated by the covalent MSH-receptor complex was readily and reversibly abolished by adrenaline, noradrenaline, dopamine or clonidine or by the absence of calcium.	Epinephrine	110-120	proopiomelanocortin	Homo sapiens	49-52
3889486-1	1985	Sensitivity to adrenaline-antagonism of the inhibitory effect of PGI2 on thrombin-induced increase in [Ca2+]i was measured in platelets from normotensive and untreated hypertensive subjects.	Epinephrine	15-25	coagulation factor II, thrombin	Homo sapiens	73-81
3931063-4	1985	Further, the response to insulin induced hypoglycemia is blunted in SCI with high lesions, and their basal levels of norepinephrine, epinephrine, and cortisol are significantly lower than those of controls.	Epinephrine	120-131	insulin	Homo sapiens	25-32
2982111-4	1985	Epinephrine (E), norepinephrine (NE) and the highly selective beta 2-agonist zinterol (ZIN) also stimulated c-AMP accumulation.	Epinephrine	0-11	cathelicidin antimicrobial peptide	Rattus norvegicus	108-113
6152786-3	1984	Bilateral adrenal demedullation attenuated the development of a raised blood pressure, while slow-release implants of adrenaline restored the development of hypertension in adrenal demedullated rats and this effect was abolished by concomitant treatment with the beta 2-adrenoceptor antagonist [C] 118551.	Epinephrine	118-128	adrenoceptor beta 2	Rattus norvegicus	263-282
2988087-7	1985	Following insulin injection, plasma epinephrine concentration increased significantly only on day 30 in calves born spontaneously at term.	Epinephrine	36-47	insulin	Bos taurus	10-17
6150550-4	1984	The effects were specific for PAF activation, since the responses of human platelets to adenosine diphosphate, thrombin, epinephrine, collagen, arachidonate, and the calcium ionophore A23187 were not inhibited by the triazolobenzodiazepines.	Epinephrine	121-132	PCNA clamp associated factor	Homo sapiens	30-33
6095862-5	1984	Thus, in rat lung the beta 2 selective antagonist ICI-118,551 was more potent in blocking incorporation than the beta 1 selective antagonist betaxolol, whereas in rat, dog and guinea pig lung and rabbit skeletal muscle epinephrine was more potent than norepinephrine in blocking labeling, indicating a beta 2 specificity in these tissues.	Epinephrine	219-230	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	22-28
6543193-0	1984	Effects of epinephrine and norepinephrine on serum parathyroid hormone and calcium in normal subjects.	Epinephrine	11-22	parathyroid hormone	Homo sapiens	51-70
6543193-2	1984	During infusion of epinephrine there was a clear rise of the serum parathyroid hormone (PTH) levels already at the lowest concentration.	Epinephrine	19-30	parathyroid hormone	Homo sapiens	67-86
6242556-4	1984	A significantly smaller augmentation of the natriuretic response to ANF was produced by equipressor does of norepinephrine and epinephrine, suggesting that the potentiation by ANG II and AVP were not entirely due to increased mean arterial pressure (MAP).	Epinephrine	111-122	natriuretic peptide A	Rattus norvegicus	68-71
6149973-1	1984	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that catalyzes the S-adenosyl-L-methionine-dependent methylation of (-)norepinephrine to (-)epinephrine in the adrenal medulla.	Epinephrine	149-163	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
6149697-7	1984	Both epinephrine and dibutyryl cAMP markedly potentiated the release of SLI stimulated by gastrin but were not themselves mutually potentiating.	Epinephrine	5-16	gastrin	Canis lupus familiaris	90-97
6439269-9	1984	Since the synergistic effect of Paf-acether and adrenaline was maintained when thrombin-degranulated platelets were used, and aspirin remained ineffective against it, it is clear that the augmented platelet responsiveness is not accounted for by the platelet release reaction.	Epinephrine	48-58	coagulation factor II, thrombin	Homo sapiens	79-87
3917908-6	1985	The physiological relevance of these differentiative actions of insulin is suggested by insulin"s ability to significantly enhance the stimulatory effects of FSH, LH, epinephrine, prostaglandin E2, and cAMP effectors, cholera toxin and 8-bromo-cAMP.	Epinephrine	167-178	insulin	Sus scrofa	88-95
6149973-1	1984	Phenylethanolamine N-methyltransferase (PNMT) is the enzyme that catalyzes the S-adenosyl-L-methionine-dependent methylation of (-)norepinephrine to (-)epinephrine in the adrenal medulla.	Epinephrine	149-163	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
6092538-1	1984	The release of S-100 protein from epididymal fat pads was enhanced by epinephrine in vitro, and about 50% of S-100 protein in the tissue was released into the medium after 2-h incubation at 37 degrees C with 10 microM epinephrine.	Epinephrine	70-81	S100 calcium binding protein A1	Homo sapiens	15-20
6240450-3	1984	Although serum from SHR and SHRSP had no specific stimulative effect on SMC growth, circulating epinephrine may accelerate cardiovascular structural changes because isoproterenol added to the culture media enhanced ornithine decarboxylase (ODC) activity.	Epinephrine	96-107	ornithine decarboxylase 1	Rattus norvegicus	215-238
6240450-3	1984	Although serum from SHR and SHRSP had no specific stimulative effect on SMC growth, circulating epinephrine may accelerate cardiovascular structural changes because isoproterenol added to the culture media enhanced ornithine decarboxylase (ODC) activity.	Epinephrine	96-107	ornithine decarboxylase 1	Rattus norvegicus	240-243
6092538-6	1984	Insulin had an inhibitory effect on the epinephrine-enhanced S-100 protein release.	Epinephrine	40-51	insulin	Homo sapiens	0-7
6092538-6	1984	Insulin had an inhibitory effect on the epinephrine-enhanced S-100 protein release.	Epinephrine	40-51	S100 calcium binding protein A1	Homo sapiens	61-66
6092538-8	1984	The increase in S-100 protein release was induced by only a pretreatment of the tissue with epinephrine.	Epinephrine	92-103	S100 calcium binding protein A1	Homo sapiens	16-21
6092538-1	1984	The release of S-100 protein from epididymal fat pads was enhanced by epinephrine in vitro, and about 50% of S-100 protein in the tissue was released into the medium after 2-h incubation at 37 degrees C with 10 microM epinephrine.	Epinephrine	218-229	S100 calcium binding protein A1	Homo sapiens	15-20
6092538-1	1984	The release of S-100 protein from epididymal fat pads was enhanced by epinephrine in vitro, and about 50% of S-100 protein in the tissue was released into the medium after 2-h incubation at 37 degrees C with 10 microM epinephrine.	Epinephrine	218-229	S100 calcium binding protein A1	Homo sapiens	109-114
6594180-5	1984	These medullary fibers, possibly originating from the norepinephrine/epinephrine-containing ventrolateral cell group (A1/C1), then appear to join additional fibers from the scattered dopamine-containing neurons positioned in the caudal midbrain (A8 CA cell group).	Epinephrine	57-68	BCL2 related protein A1	Homo sapiens	118-124
6439557-6	1984	In contrast, inhibition of human platelet adenylate cyclase by epinephrine, acting via a GTP-dependent, alpha 2-adrenergic receptor-mediated pathway, is almost completely abolished by both IAP treatment and limited proteolysis of platelet membranes.	Epinephrine	63-74	islet amyloid polypeptide	Homo sapiens	189-192
6435488-8	1984	The effects of epinephrine on low V/Q ratio areas, shunt, PaO2, QT, heart rate, and PVR were less and of shorter duration than those of isoproterenol.	Epinephrine	15-26	PVR cell adhesion molecule	Canis lupus familiaris	84-87
6148107-13	1984	Stimulation of alpha- or beta-receptors by epinephrine led to a lower secreted lipase activity.	Epinephrine	43-54	lipase G, endothelial type	Rattus norvegicus	79-85
6148865-6	1984	Recent studies, however, have suggested that the use of a nonselective beta blocker may be desirable to antagonize some beta-2-mediated metabolic effects, such as hypokalemia, induced by epinephrine.	Epinephrine	187-198	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	120-126
6095974-6	1984	The beta-adrenergic antagonist propranolol inhibits O2 production much less effectively and appears to competitively inhibit the reaction of catalase with epinephrine.	Epinephrine	155-166	catalase	Homo sapiens	141-149
6095974-5	1984	Moreover, recent work from my laboratory indicates that in vitro at alkaline pH in the presence of Mg2+, the biologically active diphenols (beta-3,4-dihydroxyphenylalanine and the beta-adrenergic agonists isoproterenol, norepinephrine, and epinephrine) appear to function as electron donor substrates for human erythrocyte catalase and inhibit the production of O2 from H2O2 at micromolar concentrations.	Epinephrine	223-234	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	140-148
6530555-1	1984	After perfusing the vascular circuit of the mesenteric artery of the rat with a Ca-free solution for 20 min, extracellular Ca was depleted, and the vasoconstrictor effect of high K solutions was abolished, while the vasopressin response was reduced by 40%, serotonin by 30% and noradrenaline and adrenaline responses by about 20%.	Epinephrine	281-291	arginine vasopressin	Rattus norvegicus	216-227
6386599-7	1984	Epinephrine, 50 and 0.164 microM, potentiated theophylline-stimulated insulin release and at 50 microM stimulated insulin secretion as an off-response even in the absence of theophylline.	Epinephrine	0-11	insulin	Gallus gallus	70-77
6386599-7	1984	Epinephrine, 50 and 0.164 microM, potentiated theophylline-stimulated insulin release and at 50 microM stimulated insulin secretion as an off-response even in the absence of theophylline.	Epinephrine	0-11	insulin	Gallus gallus	114-121
6530555-5	1984	Noradrenaline and adrenaline showed crossed tachyphylaxis, which depressed the responses to serotonin and vasopressin.	Epinephrine	3-13	arginine vasopressin	Rattus norvegicus	106-117
6541059-6	1984	The ADP-ribosyltransferase (or NAD-glycohydrolase) activity of the A-promoter (the biggest subunit) of IAP, which is responsible for the principal action of the toxin, enhancing insulin secretory responses and thereby inhibiting epinephrine hyperglycemia, was not affected by acetamindination of lysine residues.	Epinephrine	229-240	Cd47 molecule	Rattus norvegicus	103-106
6392928-1	1984	The enzyme for the synthesis of epinephrine, phenylethanolamine-N-methyltransferase, has been localized, by an indirect immunofluorescent staining method, to a subpopulation of amacrine cells in the rat retina.	Epinephrine	32-43	phenylethanolamine-N-methyltransferase	Rattus norvegicus	45-83
6090135-4	1984	Dibutyryladenosine 3",5"-monophosphate (Bt2cAMP) or epinephrine provoked significant increase in PEPck synthesis within 4-6 h. Simultaneous addition of T3 was found significantly to promote the Bt2cAMP-mediated enzyme induction.	Epinephrine	52-63	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	97-102
6476551-7	1984	Norepinephrine and epinephrine demonstrate activity at alpha 1, alpha 2, beta 1, and beta 2 receptor sites.	Epinephrine	3-14	adrenoceptor alpha 1D	Homo sapiens	55-91
6148018-2	1984	The dose required for a half-maximal effect was approximately 10(-6) M. This sensitivity is similar to that of mucin and potassium secretion induced by epinephrine from these cells.	Epinephrine	152-163	solute carrier family 13 member 2	Rattus norvegicus	111-116
6381693-5	1984	The beta-1 adrenoceptor-mediated chronotropic effects of these phenethylamines were inconsistently affected by alpha-methyl substitution, with an increase in potency being observed for alpha-methyl substitution of norepinephrine and decreases in potency being observed for alpha-methyl substitution of epinephrine and dopamine.	Epinephrine	217-228	adrenoceptor beta 1	Rattus norvegicus	4-23
6147403-1	1984	The potential role of brain adrenergic neurons in regulating noradrenergic neuronal metabolism was assessed using inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme responsible for epinephrine production.	Epinephrine	202-213	phenylethanolamine N-methyltransferase	Homo sapiens	128-166
6147403-1	1984	The potential role of brain adrenergic neurons in regulating noradrenergic neuronal metabolism was assessed using inhibitors of phenylethanolamine N-methyltransferase (PNMT), the enzyme responsible for epinephrine production.	Epinephrine	202-213	phenylethanolamine N-methyltransferase	Homo sapiens	168-172
6147403-2	1984	Two centrally active PNMT inhibitors (SK&amp;F 64139 and LY134046) were administered over a 6-day treatment period to cause prolonged reductions in epinephrine formation.	Epinephrine	148-159	phenylethanolamine N-methyltransferase	Homo sapiens	21-25
6147403-3	1984	In brain regions containing endogenous epinephrine (medulla-pons and hypothalamus), chronic treatment with PNMT inhibitors produced: 1) reductions of epinephrine content, 2) elevation of tyrosine hydroxylase activity and 3) elevation of alpha-1 and particularly alpha-2 adrenergic receptor radioligand binding sites; neither norepinephrine turnover nor beta adrenergic receptor binding was affected.	Epinephrine	39-50	phenylethanolamine N-methyltransferase	Homo sapiens	107-111
6147403-3	1984	In brain regions containing endogenous epinephrine (medulla-pons and hypothalamus), chronic treatment with PNMT inhibitors produced: 1) reductions of epinephrine content, 2) elevation of tyrosine hydroxylase activity and 3) elevation of alpha-1 and particularly alpha-2 adrenergic receptor radioligand binding sites; neither norepinephrine turnover nor beta adrenergic receptor binding was affected.	Epinephrine	150-161	phenylethanolamine N-methyltransferase	Homo sapiens	107-111
6381693-6	1984	In marked contrast, alpha-methyl substitution of epinephrine, norepinephrine and dopamine was associated with consistent and dramatic increases in potency for beta-2 adrenoceptor-mediated vasodepressor activity.	Epinephrine	49-60	adrenoceptor beta 2	Rattus norvegicus	159-178
6432062-1	1984	The effects of somatostatin on epinephrine"s ability to stimulate glucose output have been examined in hepatocytes isolated from dogs fasted overnight.	Epinephrine	31-42	somatostatin	Canis lupus familiaris	15-27
6380308-1	1984	Defective recovery from insulin-induced hypoglycemia, due to combined deficiencies of glucagon and epinephrine secretory responses to plasma glucose decrements, occurs in some patients with insulin-dependent diabetes mellitus (IDDM).	Epinephrine	99-110	insulin	Homo sapiens	24-31
6147092-19	1984	Thus, during hypoglycemia, exercise, or epinephrine infusion, prevailing plasma insulin levels govern the relative metabolic roles of epinephrine and glucagon.	Epinephrine	40-51	insulin	Canis lupus familiaris	80-87
6432531-6	1984	CB-2 phosphorylation was increased by all three hormones while CB-1 was most affected by epinephrine and vasopressin.	Epinephrine	89-100	cannabinoid receptor 1	Rattus norvegicus	63-67
6147092-19	1984	Thus, during hypoglycemia, exercise, or epinephrine infusion, prevailing plasma insulin levels govern the relative metabolic roles of epinephrine and glucagon.	Epinephrine	134-145	insulin	Canis lupus familiaris	80-87
6146545-5	1984	Epinephrine administration resulted in hyperglycemia, hyperlactatemia, and a modest increase in plasma insulin and glucagon concentrations.	Epinephrine	0-11	insulin	Homo sapiens	103-110
6381272-0	1984	Decreased response of epinephrine and norepinephrine to insulin-induced hypoglycemia in diabetic autonomic neuropathy.	Epinephrine	22-33	insulin	Homo sapiens	56-63
6381272-1	1984	The responses of epinephrine, norepinephrine and other counter-regulatory hormones to insulin-induced hypoglycemia were investigated in 5 diabetics who showed signs of autonomic neuropathy, in 7 age-matched diabetics without autonomic neuropathy and in 7 healthy subjects.	Epinephrine	17-28	insulin	Homo sapiens	86-93
6381275-3	1984	The plasma levels of insulin were increased by beta-receptor stimulation (isoproterenol, phentolamine + epinephrine) and decreased by alpha-receptor stimulation (epinephrine, norepinephrine, propranolol + epinephrine).	Epinephrine	104-115	insulin	Oryctolagus cuniculus	21-28
6381275-3	1984	The plasma levels of insulin were increased by beta-receptor stimulation (isoproterenol, phentolamine + epinephrine) and decreased by alpha-receptor stimulation (epinephrine, norepinephrine, propranolol + epinephrine).	Epinephrine	162-173	insulin	Oryctolagus cuniculus	21-28
6381275-3	1984	The plasma levels of insulin were increased by beta-receptor stimulation (isoproterenol, phentolamine + epinephrine) and decreased by alpha-receptor stimulation (epinephrine, norepinephrine, propranolol + epinephrine).	Epinephrine	162-173	insulin	Oryctolagus cuniculus	21-28
6381272-7	1984	The data demonstrate that the responses of plasma epinephrine and norepinephrine to insulin-induced hypoglycemia are impaired in diabetics with autonomic neuropathy.	Epinephrine	50-61	insulin	Homo sapiens	84-91
6086885-4	1984	A renal alpha-2 adrenoceptor response was demonstrated by showing that epinephrine could reverse the effect of vasopressin on water and sodium in the presence of beta blockade and alpha-1 destruction by POB.	Epinephrine	71-82	arginine vasopressin	Rattus norvegicus	111-122
6483727-6	1984	Intraatrial injection of 10 mg/kg of epinephrine bitartrate resulted in a significant elevation of plasma concentrations of PRL.	Epinephrine	37-59	prolactin	Meleagris gallopavo	124-127
6381871-7	1984	In addition ACTH and epinephrine were also lower after human insulin at 0.075 IU/kg.	Epinephrine	21-32	insulin	Homo sapiens	61-68
6086351-1	1984	Epinephrine modulation of the fatty acyl-CoA desaturase activities in Tetrahymena microsomes, namely the stimulation of delta 9 desaturase activity with a decreased activity of delta 12 desaturase, was markedly inhibited by dexamethasone administered 30 min prior to epinephrine addition.	Epinephrine	0-11	stearoyl-CoA desaturase	Homo sapiens	120-138
6086351-1	1984	Epinephrine modulation of the fatty acyl-CoA desaturase activities in Tetrahymena microsomes, namely the stimulation of delta 9 desaturase activity with a decreased activity of delta 12 desaturase, was markedly inhibited by dexamethasone administered 30 min prior to epinephrine addition.	Epinephrine	267-278	stearoyl-CoA desaturase	Homo sapiens	120-138
6086351-3	1984	With epinephrine or dexamethasone prior to epinephrine administration, the activities of delta 9-terminal and delta 12-terminal components were found to change in parallel with those of delta 9 and delta 12 desaturase activities respectively.	Epinephrine	5-16	stearoyl-CoA desaturase	Homo sapiens	186-217
6086351-3	1984	With epinephrine or dexamethasone prior to epinephrine administration, the activities of delta 9-terminal and delta 12-terminal components were found to change in parallel with those of delta 9 and delta 12 desaturase activities respectively.	Epinephrine	43-54	stearoyl-CoA desaturase	Homo sapiens	186-217
6146262-3	1984	Likewise, several neuropeptides, e.g., bombesin, corticotropin-releasing factor, thyrotropin-releasing factor, and somatostatin-related peptides, act within the central nervous system to produce differential changes in the relative concentrations of epinephrine and norepinephrine in plasma.	Epinephrine	250-261	gastrin releasing peptide	Homo sapiens	39-47
6377089-3	1984	A dense PNMT(phenylethanolamine-N-methyltransferase)-containing fibre network was also observed in the same region--PNMT is the final enzyme in the biosynthesis of adrenaline and has been demonstrated in the brain.	Epinephrine	164-174	phenylethanolamine-N-methyltransferase	Rattus norvegicus	8-12
6377089-3	1984	A dense PNMT(phenylethanolamine-N-methyltransferase)-containing fibre network was also observed in the same region--PNMT is the final enzyme in the biosynthesis of adrenaline and has been demonstrated in the brain.	Epinephrine	164-174	phenylethanolamine-N-methyltransferase	Rattus norvegicus	13-51
6377089-3	1984	A dense PNMT(phenylethanolamine-N-methyltransferase)-containing fibre network was also observed in the same region--PNMT is the final enzyme in the biosynthesis of adrenaline and has been demonstrated in the brain.	Epinephrine	164-174	phenylethanolamine-N-methyltransferase	Rattus norvegicus	116-120
6377089-5	1984	To examine the functional significance of the adrenergic projection to the PVN, we blocked the synthesis of adrenaline using a specific inhibitor of PNMT.	Epinephrine	108-118	phenylethanolamine-N-methyltransferase	Rattus norvegicus	149-153
6146262-3	1984	Likewise, several neuropeptides, e.g., bombesin, corticotropin-releasing factor, thyrotropin-releasing factor, and somatostatin-related peptides, act within the central nervous system to produce differential changes in the relative concentrations of epinephrine and norepinephrine in plasma.	Epinephrine	250-261	corticotropin releasing hormone	Homo sapiens	49-79
6472500-1	1984	Tracheal segments from guinea-pigs pretreated with 6-hydroxydopamine were incubated in 5 or 200 mumol X 1(-1) adrenaline at 37 degrees C. Catechol-O-methyltransferase and monoamine oxidase were inhibited by U-0521 and pargyline, respectively, and the accumulation of adrenaline in trachealis smooth muscle cells was measured by fluorescence microphotometry.	Epinephrine	267-277	catechol O-methyltransferase	Cavia porcellus	138-166
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Epinephrine	19-30	catechol-O-methyltransferase	Homo sapiens	110-139
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Epinephrine	19-30	catechol-O-methyltransferase	Homo sapiens	141-145
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Epinephrine	19-30	phenylethanolamine N-methyltransferase	Homo sapiens	151-189
6742189-6	1984	Plasma and urinary epinephrine and norepinephrine are detected by conversion to metanephrine with the enzymes catechol-O-methyl-transferase (COMT) and phenylethanolamine-N-methyltransferase (PNMT).	Epinephrine	19-30	phenylethanolamine N-methyltransferase	Homo sapiens	191-195
6733283-1	1984	We recently described a monoclonal antibody, 10E5 , that completely blocks adenosine diphosphate (ADP) induced fibrinogen binding to platelets and aggregation induced by ADP, epinephrine, and thrombin.	Epinephrine	175-186	fibrinogen beta chain	Homo sapiens	111-121
6146090-3	1984	The decrease in cyclic adenosine monophosphate (AMP) by epinephrine may account for its inhibition of insulin release.	Epinephrine	56-67	insulin	Homo sapiens	102-109
6473080-6	1984	The relative effect of catecholamines on steady-state pHi was: adrenaline = isoproterenol greater than noradrenaline.	Epinephrine	63-73	glucose-6-phosphate isomerase	Rattus norvegicus	54-57
6145423-5	1984	These data suggest: (i) that adrenaline-containing neurons could be sensitive to the neurotoxic action of 6-OHDA since they exhibit changes in TH and DBH activities; and (ii) that the determination of PNMT activity may not be sensitive enough to estimate the functional integrity of the A cell bodies or terminals.	Epinephrine	29-39	tyrosine hydroxylase	Homo sapiens	143-145
6145423-5	1984	These data suggest: (i) that adrenaline-containing neurons could be sensitive to the neurotoxic action of 6-OHDA since they exhibit changes in TH and DBH activities; and (ii) that the determination of PNMT activity may not be sensitive enough to estimate the functional integrity of the A cell bodies or terminals.	Epinephrine	29-39	dopamine beta-hydroxylase	Homo sapiens	150-153
6145423-5	1984	These data suggest: (i) that adrenaline-containing neurons could be sensitive to the neurotoxic action of 6-OHDA since they exhibit changes in TH and DBH activities; and (ii) that the determination of PNMT activity may not be sensitive enough to estimate the functional integrity of the A cell bodies or terminals.	Epinephrine	29-39	phenylethanolamine N-methyltransferase	Homo sapiens	201-205
6326157-5	1984	By contrast, peripherally administered isoproterenol, norepinephrine or epinephrine, each increased plasma levels of alpha-MSH-LI together with beta-END-LI in a dose-dependent manner.	Epinephrine	57-68	proopiomelanocortin	Rattus norvegicus	117-126
6324346-1	1984	A mouse monoclonal antibody that reacts with beta 2-microglobulin, the light chain of class I major histocompatibility antigens, inhibited the second wave of human platelet aggregation induced by adenosine diphosphate and epinephrine and blocked aggregation and platelet protein phosphorylation induced by sodium arachidonate.	Epinephrine	222-233	beta-2-microglobulin	Homo sapiens	45-65
6372523-0	1984	Circulating epinephrine stimulates renin secretion in anesthetized dogs by activation of extrarenal adrenoceptors.	Epinephrine	12-23	renin	Canis lupus familiaris	35-40
6326566-0	1984	Effect of epinephrine on fibrinogen receptor exposure by aspirin-treated platelets and platelets from concentrates in response to ADP and thrombin.	Epinephrine	10-21	fibrinogen beta chain	Homo sapiens	25-35
6326566-2	1984	Recently epinephrine was reported to induce maximal aggregation of aspirin-treated platelets when combined with ADP or thrombin, and to increase fibrinogen binding of non-aspirin treated platelets stimulated with low doses of ADP.	Epinephrine	9-20	coagulation factor II, thrombin	Homo sapiens	119-127
6326566-2	1984	Recently epinephrine was reported to induce maximal aggregation of aspirin-treated platelets when combined with ADP or thrombin, and to increase fibrinogen binding of non-aspirin treated platelets stimulated with low doses of ADP.	Epinephrine	9-20	fibrinogen beta chain	Homo sapiens	145-155
6326566-3	1984	The present study extends these observations to correlate fibrinogen binding in response to various combinations of ADP, epinephrine, and thrombin with platelet aggregation and 14C-serotonin release using aspirin-treated platelets as well as platelets from stored concentrates.	Epinephrine	121-132	fibrinogen beta chain	Homo sapiens	58-68
6326566-4	1984	When fresh platelets were stimulated with epinephrine (5 microM) together with either ADP (10 microM) or thrombin (150 mU/ml), fibrinogen binding increased by 180% compared to binding observed in response to ADP or thrombin alone.	Epinephrine	42-53	fibrinogen beta chain	Homo sapiens	127-137
6326566-4	1984	When fresh platelets were stimulated with epinephrine (5 microM) together with either ADP (10 microM) or thrombin (150 mU/ml), fibrinogen binding increased by 180% compared to binding observed in response to ADP or thrombin alone.	Epinephrine	42-53	coagulation factor II, thrombin	Homo sapiens	215-223
6326566-6	1984	While both ADP and epinephrine potentiated the aggregation and fibrinogen binding of stored platelets in response to high doses of thrombin (150 mU/ml), maximal aggregation was achieved only with thrombin (150 mU/ml) and epinephrine (5 microM) in combination.	Epinephrine	19-30	fibrinogen beta chain	Homo sapiens	63-73
6326566-6	1984	While both ADP and epinephrine potentiated the aggregation and fibrinogen binding of stored platelets in response to high doses of thrombin (150 mU/ml), maximal aggregation was achieved only with thrombin (150 mU/ml) and epinephrine (5 microM) in combination.	Epinephrine	19-30	coagulation factor II, thrombin	Homo sapiens	131-139
6372523-1	1984	The present experiments were designed to determine the location of the adrenoceptors responsible for initiating epinephrine-induced stimulation of renin secretion in vivo.	Epinephrine	112-123	renin	Canis lupus familiaris	147-152
6372523-4	1984	Intravenous infusion of epinephrine at 250 ng X kg-1 X min-1 increased one-kidney renin secretion rate more than fivefold.	Epinephrine	24-35	renin	Canis lupus familiaris	82-87
6372523-5	1984	In contrast, direct intrarenal infusion of epinephrine at 25 ng X kg-1 X min-1 only doubled renin secretion rate from the infused kidney.	Epinephrine	43-54	renin	Canis lupus familiaris	92-97
6372523-9	1984	At lower epinephrine infusion rates (10 ng X kg-1 X min-1 intravenously plus 3 ng X kg-1 X min-1 intrarenally), renin secretion rates increased submaximally but still equally from both kidneys.	Epinephrine	9-20	renin	Canis lupus familiaris	112-117
6372523-10	1984	It is concluded that epinephrine-induced stimulation of renin secretion in vivo is initiated by adrenoceptors located only extrarenally .	Epinephrine	21-32	renin	Canis lupus familiaris	56-61
6376017-3	1984	If the hyperglycemic actions of epinephrine are mediated through beta 2-adrenergic mechanisms, therapeutic efficacy (e.g., for hypertension or ischemic heart disease) could be accomplished without increased risk of hypoglycemia by selective beta 1-adrenergic blockade in such patients.	Epinephrine	32-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	65-71
6720979-2	1984	The objectives of our experiments were to determine whether continuous intravenous infusion of epinephrine raised blood pressure in a rat preparation known to respond in this way to angiotensin II in low dose and, if so, the plasma concentration of epinephrine required to raise pressure in comparison to the physiological range of plasma catecholamine concentration in the rat.	Epinephrine	95-106	angiotensinogen	Rattus norvegicus	182-196
6324691-3	1984	Epinephrine activation of phosphorylase was antagonized more efficiently by phenoxybenzamine, an alpha-antagonist, than by propranolol, a beta-antagonist, in normal rats, whereas it was antagonized totally by propranolol but only partially by phenoxybenzamine in cholestatic rat hepatocytes.	Epinephrine	0-11	amyloid beta precursor protein	Rattus norvegicus	136-142
6146542-7	1984	Insulin levels were partially suppressed by noradrenaline, while a small rise in circulating insulin was observed with adrenaline which was also associated with a large rebound rise in insulin secretion on cessation of the infusion.	Epinephrine	47-57	insulin	Homo sapiens	0-7
6376017-3	1984	If the hyperglycemic actions of epinephrine are mediated through beta 2-adrenergic mechanisms, therapeutic efficacy (e.g., for hypertension or ischemic heart disease) could be accomplished without increased risk of hypoglycemia by selective beta 1-adrenergic blockade in such patients.	Epinephrine	32-43	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	241-247
6329175-3	1984	Responses to epinephrine (via alpha-2 adrenoreceptors) and ADP were independent of extracellular Ca2+, but required maintained occupancy of thrombin receptors and intact cAMP-phosphodiesterase activity.	Epinephrine	13-24	coagulation factor II, thrombin	Homo sapiens	140-148
6326808-2	1984	Binding of fibrinogen to human platelets depends on the interaction of the gamma-chain carboxy-terminal segment with specific receptors exposed by different agonists such as ADP, epinephrine, and thrombin.	Epinephrine	179-190	fibrinogen beta chain	Homo sapiens	11-21
6143234-1	1984	As previously shown, the beta-adrenergic agonists isoproterenol, epinephrine and norepinephrine stimulate prolactin (PRL) release from superfused rat anterior pituitary cell aggregates.	Epinephrine	65-76	prolactin	Rattus norvegicus	106-115
6143631-0	1984	Adrenaline causes hypokalaemia in man by beta 2 adrenoceptor stimulation.	Epinephrine	0-10	adrenoceptor beta 2	Homo sapiens	41-60
6705791-9	1984	Adrenaline induces Ca2+ uptake only into stirred human platelets in the presence of added fibrinogen.	Epinephrine	0-10	fibrinogen beta chain	Homo sapiens	90-100
6426473-1	1984	The adrenergic amines noradrenaline and adrenaline increased flux through phenylalanine hydroxylase by approx.	Epinephrine	25-35	phenylalanine hydroxylase	Rattus norvegicus	74-99
6143631-7	1984	This suggests that adrenaline acts via beta 2 adrenoceptors in man to cause potassium influx and systemic hypokalaemia.	Epinephrine	19-29	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-45
6368295-6	1984	Intensive therapy (three daily injections of insulin) instituted in 7 out of 13 IDDM patients for up to 9 mo improved MBG (124 +/- 6 mg/dl, P less than 0.01) and ketoamine-HbA1 (7.9 +/- 0.02%, P less than 0.01) but not rates of plasma glucose recovery (0.31 +/- 0.01 mg/dl X min) and plasma glucagon (AUC 0.69 +/- 0.07 ng/ml X 150 min) and epinephrine (AUC 14.9 +/- 0.17 ng/ml X 150 min) responses.	Epinephrine	340-351	insulin	Homo sapiens	45-52
6371811-7	1984	Both C6-CM and NGF increased the catecholamine content of the cultures and reduced the relative content of epinephrine.	Epinephrine	107-118	nerve growth factor	Rattus norvegicus	5-18
6373688-6	1984	Plasma insulin concentrations before and during epinephrine infusion were higher than in the trained state only after 2 mo of inactivity.	Epinephrine	48-59	insulin	Homo sapiens	7-14
6709427-4	1984	Furthermore, the concentration of dopamine, norepinephrine, and epinephrine in the CSF increased significantly during the development of cerebral edema in all patients with Reye"s syndrome as compared with concentrations in a control population.	Epinephrine	47-58	colony stimulating factor 2	Homo sapiens	83-86
6147817-2	1984	We show that: (1) Epinephrine in the 10(-7)-10(-3) M concentration range (ED50 = 11.10(-6) M) inhibits VIP-induced cyclic AMP rise in isolated colonic epithelial cells; the maximal inhibition reaches 30% of VIP effect; epinephrine alters the efficacy of the peptide and does not modify its potency; epinephrine also reduces the basal cyclic AMP level.	Epinephrine	18-29	vasoactive intestinal peptide	Homo sapiens	103-106
6147403-7	1984	The results suggest that prolonged reductions in endogenous brain epinephrine formation produce unique effects on brain norepinephrine function; these effects are regionally distinctive and are qualitatively different from the effects seen with chronic alpha-1 or alpha-2 adrenergic receptor blockade.	Epinephrine	66-77	adrenoceptor alpha 1D	Homo sapiens	253-260
6323430-7	1984	1) Purified 41,000/35,000-Da dimer is capable of restoring the inhibitory effects of guanine nucleotides and the alpha 2-adrenergic agonist, epinephrine, on the adenylate cyclase activity of IAP-treated membranes.	Epinephrine	141-152	islet amyloid polypeptide	Homo sapiens	191-194
6323431-14	1984	The irreversible inhibition of adenylate cyclase caused by GTP gamma S (plus epinephrine) in membranes is highly correlated with the liberation of free 35,000-Da subunit activity and is inversely related to the 41,000-Da IAP substrate activity in detergent extracts prepared therefrom.	Epinephrine	77-88	islet amyloid polypeptide	Homo sapiens	221-224
6323431-15	1984	The increase in free 35,000-Da subunit activity in extracts and the inhibition of adenylate cyclase activity in GTP gamma S (plus epinephrine)-treated membranes are both markedly inhibited by treatment with IAP.	Epinephrine	130-141	islet amyloid polypeptide	Homo sapiens	207-210
6321867-2	1984	Injection with follicle stimulating hormone, luteinizing hormone, prostaglandin F2 alpha, cyclic AMP or epinephrine to norepinephrine desensitized testis caused stimulation of ODC activity.	Epinephrine	104-115	ornithine decarboxylase 1	Rattus norvegicus	176-179
6321868-7	1984	1-Propranolol alone reduced the electrically (at 2 Hz) evoked release, and this effect was completely abolished when the adrenaline content in the brain was drastically reduced by use of a potent PNMT inhibitor, DCMB.	Epinephrine	121-131	phenylethanolamine-N-methyltransferase	Rattus norvegicus	196-200
6370767-4	1984	When insulin was infused together with adrenaline and propranolol in normal subjects in doses exceeding those given to the diabetics (plasma insulin rose threefold), the rise in glucose production was still threefold greater than in the diabetic patients (p less than 0.02).	Epinephrine	39-49	insulin	Homo sapiens	141-148
6147817-5	1984	(3) The inhibition of VIP action by epinephrine is reversed by the alpha antagonists dihydroergotamine, phentolamine and the alpha 2 antagonist yohimbine, while unaffected by the beta antagonist propranolol and the alpha 1 antagonist prazosin, (4) Epinephrine inhibits VIP-stimulated adenylate cyclase activity in preparations of colonic plasma membranes.	Epinephrine	248-259	vasoactive intestinal peptide	Homo sapiens	22-25
6147817-2	1984	We show that: (1) Epinephrine in the 10(-7)-10(-3) M concentration range (ED50 = 11.10(-6) M) inhibits VIP-induced cyclic AMP rise in isolated colonic epithelial cells; the maximal inhibition reaches 30% of VIP effect; epinephrine alters the efficacy of the peptide and does not modify its potency; epinephrine also reduces the basal cyclic AMP level.	Epinephrine	18-29	vasoactive intestinal peptide	Homo sapiens	207-210
6147817-2	1984	We show that: (1) Epinephrine in the 10(-7)-10(-3) M concentration range (ED50 = 11.10(-6) M) inhibits VIP-induced cyclic AMP rise in isolated colonic epithelial cells; the maximal inhibition reaches 30% of VIP effect; epinephrine alters the efficacy of the peptide and does not modify its potency; epinephrine also reduces the basal cyclic AMP level.	Epinephrine	219-230	vasoactive intestinal peptide	Homo sapiens	103-106
6147817-2	1984	We show that: (1) Epinephrine in the 10(-7)-10(-3) M concentration range (ED50 = 11.10(-6) M) inhibits VIP-induced cyclic AMP rise in isolated colonic epithelial cells; the maximal inhibition reaches 30% of VIP effect; epinephrine alters the efficacy of the peptide and does not modify its potency; epinephrine also reduces the basal cyclic AMP level.	Epinephrine	299-310	vasoactive intestinal peptide	Homo sapiens	103-106
6147817-5	1984	(3) The inhibition of VIP action by epinephrine is reversed by the alpha antagonists dihydroergotamine, phentolamine and the alpha 2 antagonist yohimbine, while unaffected by the beta antagonist propranolol and the alpha 1 antagonist prazosin, (4) Epinephrine inhibits VIP-stimulated adenylate cyclase activity in preparations of colonic plasma membranes.	Epinephrine	36-47	vasoactive intestinal peptide	Homo sapiens	22-25
6147817-5	1984	(3) The inhibition of VIP action by epinephrine is reversed by the alpha antagonists dihydroergotamine, phentolamine and the alpha 2 antagonist yohimbine, while unaffected by the beta antagonist propranolol and the alpha 1 antagonist prazosin, (4) Epinephrine inhibits VIP-stimulated adenylate cyclase activity in preparations of colonic plasma membranes.	Epinephrine	36-47	vasoactive intestinal peptide	Homo sapiens	269-272
6143680-5	1984	Chloranolol and propranolol were able to antagonize the fall in adrenaline concentration due to the phenylethanolamine-N-methyltransferase (PNMT) inhibitor, Lilly 87130, only in the region of the solitary tract nucleus.	Epinephrine	64-74	phenylethanolamine-N-methyltransferase	Rattus norvegicus	100-138
6142395-7	1984	On the other hand, prazosine (alpha 1-type antagonist) blocked the stimulatory effect of epinephrine and norepinephrine on AC system.	Epinephrine	89-100	adrenoceptor alpha 1D	Homo sapiens	30-37
6143680-5	1984	Chloranolol and propranolol were able to antagonize the fall in adrenaline concentration due to the phenylethanolamine-N-methyltransferase (PNMT) inhibitor, Lilly 87130, only in the region of the solitary tract nucleus.	Epinephrine	64-74	phenylethanolamine-N-methyltransferase	Rattus norvegicus	140-144
6366415-1	1984	Decline of plasma dopamine (DA), norepinephrine (NE), and epinephrine (EP) levels after iv administration of a 100 microgram bolus of LRF has been reported in normal men.	Epinephrine	36-47	CREB3 regulatory factor	Homo sapiens	134-137
6142006-1	1984	We tested the hypothesis that (1) beta 1-selective and nonselective beta adrenoceptor blockades have a different influence on stress-induced catecholamine overshoot, and (2) beta 1-selective blockade shifts the epinephrine/norepinephrine ratio in favor of norepinephrine.	Epinephrine	211-222	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	174-180
6230372-2	1984	Plasma proteins specifically inhibited the thrombin- and ADP/epinephrine-induced vWf binding to activated platelets but did not inhibit the ristocetin-induced vWf binding.	Epinephrine	61-72	von Willebrand factor	Homo sapiens	81-84
6142057-3	1984	During somatostatin with insulin alone mean glucose production fell from 1.5 +/- 0.05 to 0.7 +/- 0.2 mg/kg per min and mean plasma glucose declined from 93 +/- 3 to 67 +/- 4 mg/dl over 1 h; glucose production then increased to base-line rates and plasma glucose plateaued at 64-67 mg/dl over 2 h. This plateau was associated with, and is best attributed to, an eightfold increase in mean plasma epinephrine.	Epinephrine	395-406	insulin	Homo sapiens	25-32
6230372-3	1984	When normal plasma was heat defibrinated, monoclonal-labeled vWf was bound to platelets following thrombin or ADP/epinephrine stimulation.	Epinephrine	114-125	von Willebrand factor	Homo sapiens	61-64
6230372-8	1984	These studies show that thrombin-induced and ADP/epinephrine-induced vWf binding to platelets does not occur in the plasma milieu, although at reduced levels of fibrinogen, vWf binding to stimulated platelets can be demonstrated.	Epinephrine	49-60	von Willebrand factor	Homo sapiens	69-72
6230372-8	1984	These studies show that thrombin-induced and ADP/epinephrine-induced vWf binding to platelets does not occur in the plasma milieu, although at reduced levels of fibrinogen, vWf binding to stimulated platelets can be demonstrated.	Epinephrine	49-60	von Willebrand factor	Homo sapiens	173-176
6699683-2	1984	Locations of most active pressor responses were compared to regions containing neurons labeled immunocytochemically for phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing the synthesis of adrenaline.	Epinephrine	206-216	phenylethanolamine-N-methyltransferase	Rattus norvegicus	120-158
6699683-2	1984	Locations of most active pressor responses were compared to regions containing neurons labeled immunocytochemically for phenylethanolamine N-methyltransferase (PNMT), the enzyme catalyzing the synthesis of adrenaline.	Epinephrine	206-216	phenylethanolamine-N-methyltransferase	Rattus norvegicus	160-164
6699683-5	1984	The location of the most active pressor region in the ventrolateral medulla corresponded closely with the location of C1 adrenaline-synthesizing (PNMT-containing) neurons.	Epinephrine	121-131	phenylethanolamine-N-methyltransferase	Rattus norvegicus	146-150
6424261-6	1984	Consequently, the ADP- and adrenaline-induced secondary aggregation and [3H]serotonin release in citrated PRP and the major effects of collagen were also inhibited.	Epinephrine	27-37	prion protein	Homo sapiens	106-109
6321168-14	1984	The results suggest that insulin and glucocorticoids modulate the effects of glucagon and epinephrine on hepatocytes by exerting long-term influences on the cyclic AMP system.	Epinephrine	90-101	transmembrane serine protease 5	Rattus norvegicus	164-167
6322894-5	1984	Studies using selective agonists and antagonists demonstrate that the excitatory response of rat platelets to adrenaline is mediated by an alpha 2-adrenoceptor, and the inhibitory response of rabbit platelets to adrenaline by a beta 2-adrenoceptor as is the case in other species which have been examined.	Epinephrine	212-222	adrenoceptor beta 2	Homo sapiens	228-247
6537889-2	1984	Prolactin decreased the tension in the hypophyseal-adrenal system, normalized adrenaline and noradrenaline content in the heart and adrenals, and prevented the development of pathological alterations in the myocardium under emotional-painful stress.	Epinephrine	78-88	prolactin	Rattus norvegicus	0-9
6322894-8	1984	The nature of the effect of adrenaline on the response of mammalian platelets to other excitatory agonists, e.g. ADP-alpha-S, appears therefore to be largely determined by the absolute number of alpha 2-adrenoceptors and by the relative content of alpha 2- and beta 2-adrenoceptors on these cells for the species which have been examined in this analysis.	Epinephrine	28-38	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	248-267
6365368-2	1984	C1 neurons were identified in rat with antibodies to the adrenaline synthesizing enzyme, PNMT.	Epinephrine	57-67	phenylethanolamine N-methyltransferase	Homo sapiens	89-93
6150762-5	1984	A variable number of paraganglia were positive for phenylethanolamine-N-methyltransferase, which suggested that they synthesized epinephrine.	Epinephrine	129-140	phenylethanolamine-N-methyltransferase	Rattus norvegicus	51-89
6690194-2	1984	During a second study, adrenaline was infused intravenously in six resting subjects at a rate of 0.025 micrograms min-1 kg-1.	Epinephrine	23-33	CD59 molecule (CD59 blood group)	Homo sapiens	114-124
6368260-1	1984	Insulin receptor interaction was examined in fatty plasma membranes of rats given adrenaline hydrochloride for 6 days in a dose producing a 10-20-fold increase in adrenaline excretion.	Epinephrine	82-106	insulin receptor	Rattus norvegicus	0-16
6383859-4	1984	NGF-treatment led to lower contents of adrenaline, noradrenaline and dopamine.	Epinephrine	39-49	nerve growth factor	Homo sapiens	0-3
6383859-9	1984	It may be concluded that NGF influences the liberation of adrenaline, noradrenaline and dopamine in tissue culture: though NGF treated cells contained more catecholamine granula, the catecholamines were retained in the pheochromocytoma cells.	Epinephrine	58-68	nerve growth factor	Homo sapiens	25-28
6383859-9	1984	It may be concluded that NGF influences the liberation of adrenaline, noradrenaline and dopamine in tissue culture: though NGF treated cells contained more catecholamine granula, the catecholamines were retained in the pheochromocytoma cells.	Epinephrine	58-68	nerve growth factor	Homo sapiens	123-126
6358412-4	1984	On the other hand, levels of NSE subunit (gamma subunit or 14-3-2 protein) in adipose tissue (0.51 +/- 0.03 gamma gamma-equivalent pmol/mg protein) were increased to 170% of control by serial injection (for 7 days) of epinephrine or norepinephrine with little change of the level of enolase alpha subunit on a mg protein basis.	Epinephrine	218-229	enolase 2	Rattus norvegicus	29-32
6698384-1	1984	An injection of 20 micrograms/l kg body wt of adrenaline, acetylcholine and histamine decreased AspAT and A1AT aminotransferase activity in blood plasma serum of 1 to 3-day-old Leghorn chicks.	Epinephrine	46-56	serpin family A member 1	Homo sapiens	106-110
6423649-6	1984	Phosphorylation of myosin light chain and a 40,000-dalton protein triggered by AA (two- to fivefold) was reversed to basal levels by PGI2 but was completely restored to peak levels upon addition of the epinephrine and AA mixture.	Epinephrine	202-213	myosin heavy chain 14	Homo sapiens	19-25
6146190-4	1984	Insulin markedly increased plasma adrenaline in controls but had no discernible effect in adrenalectomized subjects.	Epinephrine	34-44	insulin	Homo sapiens	0-7
6694137-2	1984	Adrenaline (which stimulates the alpha-, beta 1- and beta 2-adrenoceptors) and phenylephrine (an alpha-stimulating agent) produced a sudden increase in tonus and in the amplitude and frequency of contractions.	Epinephrine	0-10	adrenoceptor beta 1	Rattus norvegicus	33-73
6330784-3	1984	The anti-amnestic effect of epinephrine, but not that of ACTH or beta-endorphin, was also antagonized by the alpha 1-adrenergic receptor blocker, prazosin HC1 (2.0 mg/kg).	Epinephrine	28-39	CYCS pseudogene 39	Homo sapiens	155-158
6330784-4	1984	These findings suggest that alpha 2-adrenergic receptors are involved both in the amnestic and in the anti-amnestic effect of ACTH, beta-endorphin and epinephrine at the doses used, and that, in the case of the anti-amnestic effect of epinephrine, alpha 1 receptors also are involved.	Epinephrine	235-246	proopiomelanocortin	Homo sapiens	126-130
6314140-0	1983	Hypokalemia from beta2-receptor stimulation by circulating epinephrine.	Epinephrine	59-70	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	17-22
6314140-4	1983	The difference in responses to the two catecholamines was ascribed to the relative beta2-selectivity of epinephrine.	Epinephrine	104-115	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	83-88
6314140-8	1983	Fifteen-fold to 30-fold increases in circulating epinephrine concentration appear to cause hypokalemia by a specific beta2-receptor effect distinct from other actions of epinephrine.	Epinephrine	49-60	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	117-122
6365642-1	1983	Insulin action was assessed in 5 cytoplasmic islet cell antibody (ICA) positive non-diabetics, 8 ICA positive (type I) non-insulin-treated diabetics, 7 ICA negative insulin-treated diabetics by measurement of steady state plasma glucose (SSPG) levels during a combined intravenous infusion of propranolol, adrenaline, glucose and insulin.	Epinephrine	306-316	insulin	Homo sapiens	0-7
6139182-4	1983	The relative potencies of isoprenaline, adrenaline, and noradrenaline for inhibition of (+/-)-[125I]iodocyanopindolol binding and activation of adenylate cyclase were 1:10:10, indicating a population composed mainly of beta 1-adrenoceptors.	Epinephrine	40-50	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	219-225
6673082-3	1983	Parallel variation in the NH2- and COOH-terminal gastrin concentrations occurred both during meal stimulation and as response to adrenaline or secretin infusion.	Epinephrine	129-139	gastrin	Homo sapiens	49-56
6663484-0	1983	Coil leads to helix transition in polyadenylic acid induced by the binding of epinephrine, norepinephrine, and isoproterenol: circular dichroism study.	Epinephrine	78-89	coilin	Homo sapiens	0-4
6663484-1	1983	A circular dichroism spectropolarimetric study on the conformation of polyadenylic acid (poly A) in neutral solutions demonstrated a coil leads to helix transition induced by intercalative binding of critical amounts of epinephrine, norepinephrine, and isoproterenol relative to poly A.	Epinephrine	220-231	coilin	Homo sapiens	133-137
6140642-3	1983	The influence of the Bordetella pertussis toxin, islet-activating protein (IAP), was studied on adrenaline and PGE1-induced GTPase stimulation and on adrenaline-induced adenylate cyclase inhibition.	Epinephrine	96-106	islet amyloid polypeptide	Homo sapiens	75-78
6140642-4	1983	Pretreatment of platelet membranes with IAP greatly reduced the adrenaline-induced inhibition of the platelet adenylate cyclase.	Epinephrine	64-74	islet amyloid polypeptide	Homo sapiens	40-43
6651777-7	1983	The finding that type L HSL is stimulated by adrenaline indicates that the enzyme that is being activated is found in the cell and not associated with an extracellular compartment of the myocardium.	Epinephrine	45-55	lipase E, hormone sensitive type	Homo sapiens	24-27
6226659-6	1983	AP-2 inhibits ADP-induced binding of radiolabeled fibrinogen to gel-filtered platelets in a noncompetitive fashion, consistent with the previous observation that AP-2 also inhibits the aggregation of platelets in plasma induced by a number of physiologic agonists, including adenosine diphosphate, epinephrine, collagen, thrombin, and arachidonic acid.	Epinephrine	298-309	transcription factor AP-2 alpha	Homo sapiens	0-4
6226659-6	1983	AP-2 inhibits ADP-induced binding of radiolabeled fibrinogen to gel-filtered platelets in a noncompetitive fashion, consistent with the previous observation that AP-2 also inhibits the aggregation of platelets in plasma induced by a number of physiologic agonists, including adenosine diphosphate, epinephrine, collagen, thrombin, and arachidonic acid.	Epinephrine	298-309	transcription factor AP-2 alpha	Homo sapiens	162-166
6194153-8	1983	DTNB also inhibited the effect of insulin to stimulate glucose oxidation and to inhibit epinephrine-stimulated cyclic AMP production.	Epinephrine	88-99	insulin	Homo sapiens	34-41
6352871-5	1983	Addition of insulin to chromaffin cell cultures produced a doubling of cellular protein and opioid peptide levels by 6 days and produced a concentration-dependent increase in the dopamine and norepinephrine contents of the cells with only a slight elevation in cell epinephrine.	Epinephrine	195-206	insulin	Bos taurus	12-19
6193953-2	1983	Epinephrine (E) (10(-6) M) caused a significant increase in TSH, alpha-subunit, and TSH beta release into the medium (P less than 0.001, P less than 0.001, and P less than 0.01, respectively).	Epinephrine	0-11	thyroid stimulating hormone subunit beta	Bos taurus	84-92
6195471-3	1983	The selective beta 2-adrenoceptor antagonist ICI 118,551 was employed to reveal the intrinsic beta 2-adrenoceptor activation induced by alpha-methylnorepinephrine and (--)-epinephrine, measured as a potentiation of the increase in diastolic pressure.	Epinephrine	167-183	adrenoceptor beta 2	Rattus norvegicus	14-33
6350810-1	1983	We examined the response of plasma glucose concentration and glucose counterregulatory factors (eg, glucagon, epinephrine, growth hormone, cortisol, and norepinephrine) to insulin-induced hypoglycemia in four patients with Shy-Drager syndrome and in five control subjects to determine if glucose counterregulation occurred in the patients with sympathetic and parasympathetic nervous system defects.	Epinephrine	110-121	insulin	Homo sapiens	172-179
6350810-3	1983	Although the insulin-induced hypoglycemia in the control subjects provoked a rapid release of epinephrine, followed by an increase in the plasma glucagon, growth hormone, and cortisol levels, it did not cause a significant increase in any of the glucose counterregulatory factors in the patients.	Epinephrine	94-105	insulin	Homo sapiens	13-20
6310752-2	1983	It was found that the activity of adrenomedullary and regional brain phenylethanolamine N-methyltransferase is at least four times higher in F344 rats than in BUF rats; these strain-dependent differences corresponded directly with the epinephrine content of the medulla-pons and hypothalamus.	Epinephrine	235-246	phenylethanolamine-N-methyltransferase	Rattus norvegicus	69-107
6614167-2	1983	Epinephrine infusion produced a rise in blood glucose (50-60%) and plasma insulin (30-40%), whereas glucagon levels increased only at 30 min (19%, P less than 0.05).	Epinephrine	0-11	insulin	Homo sapiens	74-81
6872952-0	1983	The role of compartmentalization of epinephrine in the regulation of phenylethanolamine N-methyltransferase synthesis in rat adrenal medulla.	Epinephrine	36-47	phenylethanolamine-N-methyltransferase	Rattus norvegicus	69-107
6872952-12	1983	Epinephrine added to cultured tissue decreased the rate of biosynthesis of PNMT by 22%, an extent similar to that observed after hypophysectomy.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Rattus norvegicus	75-79
6195471-3	1983	The selective beta 2-adrenoceptor antagonist ICI 118,551 was employed to reveal the intrinsic beta 2-adrenoceptor activation induced by alpha-methylnorepinephrine and (--)-epinephrine, measured as a potentiation of the increase in diastolic pressure.	Epinephrine	167-183	adrenoceptor beta 2	Rattus norvegicus	94-113
6195472-5	1983	By using the selective beta 2-adrenoceptor antagonist ICI 118,551, the interaction between the alpha 1-adrenoceptor-mediated vasoconstriction of (--)-epinephrine and alpha-methylnorepinephrine with their intrinsic beta 2-adrenoceptor agonistic effects was investigated.	Epinephrine	145-161	adrenoceptor beta 2	Rattus norvegicus	23-42
6224849-8	1983	The percentage of natural killer/killer cells (HNK-1+) increased from a baseline of 15.5% before epinephrine injection to 29.6% at 30 min postinjection, then declined to 11.4% at 2 hr.	Epinephrine	97-108	beta-1,3-glucuronyltransferase 1	Homo sapiens	47-52
6195472-5	1983	By using the selective beta 2-adrenoceptor antagonist ICI 118,551, the interaction between the alpha 1-adrenoceptor-mediated vasoconstriction of (--)-epinephrine and alpha-methylnorepinephrine with their intrinsic beta 2-adrenoceptor agonistic effects was investigated.	Epinephrine	145-161	adrenoceptor beta 2	Rattus norvegicus	214-233
6889313-6	1983	However, epinephrine was effective in elevating ceruloplasmin levels in the cell cytosol.	Epinephrine	9-20	ceruloplasmin	Rattus norvegicus	48-61
6411841-4	1983	When PRP was stimulated with subthreshold concentrations of the Ca++ ionophore A23187 followed by subthreshold concentrations of ADP or epinephrine, a marked potentiation of platelet aggregation and TXA2 generation was observed.	Epinephrine	136-147	prion protein	Homo sapiens	5-8
6411841-5	1983	Incubation of PRP with diltiazem in a pharmacologic range resulted in marked reduction in ionophore A23187-induced potentiation of platelet activity caused by ADP or epinephrine.	Epinephrine	166-177	prion protein	Homo sapiens	14-17
6305487-1	1983	The kinetics for activation of the cyclic adenosine 3":5"-monophosphate (cyclic AMP)-dependent protein kinase (PKA) and thymidine incorporation into DNA was investigated in epinephrine- and prostaglandin E1 (PGE1)-treated murine P1798 lymphosarcoma cells.	Epinephrine	173-184	mitogen-activated protein kinase kinase kinase 14	Mus musculus	95-109
6305487-8	1983	In the presence of microM epinephrine, the cyclic AMP concentration was approximately 3-fold greater than that required for maximal PKA activation.	Epinephrine	26-37	mitogen-activated protein kinase kinase kinase 14	Mus musculus	132-135
6305487-1	1983	The kinetics for activation of the cyclic adenosine 3":5"-monophosphate (cyclic AMP)-dependent protein kinase (PKA) and thymidine incorporation into DNA was investigated in epinephrine- and prostaglandin E1 (PGE1)-treated murine P1798 lymphosarcoma cells.	Epinephrine	173-184	mitogen-activated protein kinase kinase kinase 14	Mus musculus	111-114
6305487-9	1983	In this case, the duration of the activation time for PKA was also 3- to 4-fold longer than that observed with 0.1 microM epinephrine.	Epinephrine	122-133	mitogen-activated protein kinase kinase kinase 14	Mus musculus	54-57
6348987-3	1983	In this study we investigated the influence of epinephrine on insulin-mediated glucose uptake by peripheral tissue.	Epinephrine	47-58	insulin	Homo sapiens	62-69
6310430-9	1983	The effect of l-epinephrine or l-isoproterenol on plasma B was associated with a parallel and dose-related increase in plasma ACTHi, beta-ENDi and alpha-MSHi.	Epinephrine	14-27	proopiomelanocortin	Rattus norvegicus	147-157
6348987-13	1983	Epinephrine-induced skeletal muscle insulin resistance may play a major role in insulin-resistant states and may contribute to accelerated protein catabolism seen following injury.	Epinephrine	0-11	insulin	Homo sapiens	36-43
6305832-4	1983	After salt loading there was a significant reduction in plasma catecholamine concentrations with a significant relationship between changes in upright plasma epinephrine levels and changes in CD25 (r = 0.904, p less than 0.01) and in the slopes for delta HR/IS (r = 0.983, p less than 0.001) and delta cAMP/IS (r = 0.922, p less than 0.001).	Epinephrine	158-169	interleukin 2 receptor subunit alpha	Homo sapiens	192-196
6223940-1	1983	The binding of 125I-von Willebrand factor (125I-vWF) to platelets stimulated by thrombin, ADP, and a combination of ADP + epinephrine (EPI) is specific, saturable, and reversible.	Epinephrine	135-138	von Willebrand factor	Homo sapiens	20-41
6223940-1	1983	The binding of 125I-von Willebrand factor (125I-vWF) to platelets stimulated by thrombin, ADP, and a combination of ADP + epinephrine (EPI) is specific, saturable, and reversible.	Epinephrine	135-138	von Willebrand factor	Homo sapiens	48-51
6353019-3	1983	The action of IAP on insulin secretion in the animals was estimated by three kinds of tests: effects on epinephrine hyperglycemia, plasma insulin and blood glucose concentrations following the injection of stimuli, and glucose tolerance.	Epinephrine	104-115	Cd47 molecule	Rattus norvegicus	14-17
6301579-0	1983	Exposure of fibrinogen receptors on fresh and stored platelets by ADP and epinephrine as single agents and as a pair.	Epinephrine	74-85	fibrinogen beta chain	Homo sapiens	12-22
6301579-3	1983	Following stimulation with 10 microM ADP or 20 microM epinephrine, platelet suspensions from fresh concentrates bound 125I-fibrinogen in a reaction that reached completion within 30 min.	Epinephrine	54-65	fibrinogen beta chain	Homo sapiens	123-133
6301579-4	1983	Significantly less binding occurred in suspensions from platelet concentrates that had been stored for 5 days at 22 degrees C. When stimulated by ADP and epinephrine as a pair (2 microM each), binding of fibrinogen to platelets was complete within 10-15 min and was not significantly decreased in suspensions from stored concentrates.	Epinephrine	154-165	fibrinogen beta chain	Homo sapiens	204-214
6301579-8	1983	We conclude that storage for 5 days at 22 degrees C impairs the exposure of fibrinogen receptors on platelets in response to ADP or epinephrine when used as single agents, without affecting the glycoprotein IIb-IIIa complex quantitatively.	Epinephrine	132-143	fibrinogen beta chain	Homo sapiens	76-86
6306055-10	1983	Incubation of muscles with added parathyroid hormone produced a diminished responsiveness towards epinephrine or serotonin regulation of amino acid release and cAMP formation in the presence compared to the absence of parathyroid hormone.	Epinephrine	98-109	parathyroid hormone	Rattus norvegicus	33-52
6306055-11	1983	In the absence of parathyroid hormone, detectable inhibition of alanine and glutamine release was produced by 10(-9) M epinephrine, whereas in the presence of parathyroid hormone (1,000 ng/ml) inhibition of alanine and glutamine release required 10(-6) M or greater epinephrine.	Epinephrine	266-277	parathyroid hormone	Rattus norvegicus	159-178
6612681-6	1983	Indomethacin (1 microgram/ml), a cyclooxygenase inhibitor, remarkably inhibited epinephrine plus ADP induced serotonin release, 40K-dalton protein phosphorylation and DG production although this agent had little effect on the same reactions induced by thrombin.	Epinephrine	80-91	coagulation factor II, thrombin	Homo sapiens	252-260
6192806-1	1983	Adrenaline, 3-isobutyl-1-methylxanthine (MIX) and dibutyryl cyclic AMP (Bt2 cyclic AMP) stimulated type-L hormone-sensitive lipase (HSL) activity when measurements were made on defatted rat heart powders.	Epinephrine	0-10	lipase E, hormone sensitive type	Rattus norvegicus	132-135
6134529-3	1983	On the basis of a preference of beta 2- and alpha 2-adrenergic receptors for epinephrine, the hormone, and of beta 1-and alpha 1-receptors for norepinephrine, the neurotransmitter, it was postulated that the alpha 2- and beta 2-receptors are predominantly epinephrinergic in nature and located extrajunctionally and presynaptically whereas the alpha 1- and beta 1-receptors are predominantly norepinephrinergic in nature and located postsynaptically in the sympathetic terminal junction.	Epinephrine	77-88	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	32-38
6192806-3	1983	This activation was reversible, because removal of adrenaline from the perfusate was accompanied by the return of type-L HSL activity to control levels.	Epinephrine	51-61	lipase E, hormone sensitive type	Rattus norvegicus	121-124
6192806-6	1983	198, 159-166] that perfusion with low levels of adrenaline, MIX or Bt2 cyclic AMP reduced type-L HSL activity below control levels when measurements were made in aqueous homogenates.	Epinephrine	48-58	lipase E, hormone sensitive type	Rattus norvegicus	97-100
6136270-1	1983	Vasopressin or alpha-adrenergic agents such as phenylephrine or adrenaline, but not glucagon, elicited an initial decrease in flux through pyruvate dehydrogenase assayed by 14CO2 production from [1-14C]pyruvate in perfused rat liver.	Epinephrine	64-74	arginine vasopressin	Rattus norvegicus	0-11
6405112-0	1983	Release of histamine and adrenaline in vivo following intravenous administration of neurotensin.	Epinephrine	25-35	neurotensin	Rattus norvegicus	84-95
6133873-5	1983	The major 32P-peptide phosphorylated by epinephrine co-migrated with the major 32P-peptide phosphorylated in vitro by the cAMP-dependent protein kinase, while the 32P-peptide phosphorylated in response to insulin co-migrated with that phosphorylated by casein kinase-I and casein kinase-II.	Epinephrine	40-51	casein kinase 1, epsilon	Rattus norvegicus	253-268
6405112-3	1983	Plasma adrenaline levels increased transiently 1 min after NT injection, and adrenalectomy and treatment with compound 48/80 or diphenhydramine markedly reduced the elevation of adrenaline levels after NT injection.	Epinephrine	7-17	neurotensin	Rattus norvegicus	59-61
6843289-0	1983	Fasting reduces the response of liver glycogen phosphorylase to physiological levels of epinephrine in rats.	Epinephrine	88-99	glycogen phosphorylase L	Rattus norvegicus	32-60
6405112-3	1983	Plasma adrenaline levels increased transiently 1 min after NT injection, and adrenalectomy and treatment with compound 48/80 or diphenhydramine markedly reduced the elevation of adrenaline levels after NT injection.	Epinephrine	178-188	neurotensin	Rattus norvegicus	202-204
6405112-5	1983	These results provide direct evidence of the release of endogenous histamine and adrenaline following NT administration, and suggest the contribution of these amines to the NT-induced triphasic blood pressure responses (the first depressor, second pressor and third depressor responses) reported previously.	Epinephrine	81-91	neurotensin	Rattus norvegicus	102-104
6831836-5	1983	On a separate occasion, two doses of L-adrenaline (0.025 micrograms min-1 kg-1 and 0.05 micrograms min-1 kg-1) were infused in the same subjects at rest to produce two mean plasma levels similar to those found on exercise.	Epinephrine	37-49	CD59 molecule (CD59 blood group)	Homo sapiens	68-84
6682686-3	1983	Administration of adrenaline entailed a more prolonged and appreciable reduction in the content of both cytochrome P-450 and cytochrome b5.	Epinephrine	18-28	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	104-120
6682686-3	1983	Administration of adrenaline entailed a more prolonged and appreciable reduction in the content of both cytochrome P-450 and cytochrome b5.	Epinephrine	18-28	cytochrome b5 type A	Rattus norvegicus	125-138
6840400-2	1983	In response to insulin-induced hypoglycemia, significant increases in epinephrine, norepinephrine, cortisol, and growth hormone were measured in all subjects, while in five of the six patients glucagon levels did not increase at all.	Epinephrine	70-81	insulin	Homo sapiens	15-22
6832567-4	1983	In contrast, in those with abnormally high serum adrenaline, the serum gastrin levels in the basal state and in response to a test meal were significantly higher than in patients with a normal serum adrenaline level and in normal subjects.	Epinephrine	49-59	gastrin	Homo sapiens	71-78
6832567-4	1983	In contrast, in those with abnormally high serum adrenaline, the serum gastrin levels in the basal state and in response to a test meal were significantly higher than in patients with a normal serum adrenaline level and in normal subjects.	Epinephrine	199-209	gastrin	Homo sapiens	71-78
6832567-6	1983	These results indicate that adrenaline stimulates serum gastrin secretion not only in the basal state, but also in response to a test meal.	Epinephrine	28-38	gastrin	Homo sapiens	56-63
6856397-1	1983	Phenylethanolamine N-methyl transferase (PNMT), the terminal enzyme in epinephrine biosynthesis, was identified in fetal and newborn ovine lung.	Epinephrine	71-82	phenylethanolamine N-methyltransferase	Homo sapiens	0-39
6856397-1	1983	Phenylethanolamine N-methyl transferase (PNMT), the terminal enzyme in epinephrine biosynthesis, was identified in fetal and newborn ovine lung.	Epinephrine	71-82	phenylethanolamine N-methyltransferase	Homo sapiens	41-45
6134281-4	1983	Pretreatment of intact WT or cyc- cells with 1.0 microM epinephrine for 15 min (desensitization) resulted in a greater loss of the 55,000 Mr polypeptide (40-60%) relative to the 65,000 Mr peptide (10-30% loss).	Epinephrine	56-67	cytochrome c, somatic	Homo sapiens	29-32
6300586-4	1983	Agonist potency isoproterenol greater than epinephrine greater than norepinephrine indicated that early human placenta contains an adrenergic receptor of beta-2 subtype.	Epinephrine	43-54	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	154-160
6408754-6	1983	Subthreshold concentrations of PAF enhanced the platelet aggregation triggered by suboptimal concentrations of ADP, epinephrine, or collagen.	Epinephrine	116-127	PCNA clamp associated factor	Homo sapiens	31-34
6408754-7	1983	Vice versa non-aggregating concentrations of ADP, epinephrine, collagen, Ca-ionophore A 23,187, or arachidonic acid amplified PAF-induced platelet aggregation.	Epinephrine	50-61	PCNA clamp associated factor	Homo sapiens	126-129
6298010-0	1983	Angiotensin II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects.	Epinephrine	74-85	angiotensinogen	Homo sapiens	0-14
6298010-2	1983	Angiotensin II also inhibited cAMP accumulation induced by either glucagon or epinephrine in Ca2+-depleted hepatocytes.	Epinephrine	78-89	angiotensinogen	Homo sapiens	0-14
6298402-5	1983	These data are consistent with the hypothesis that norepinephrine and epinephrine stimulate renin release by activation of both the renal beta and renal alpha adrenoceptors.	Epinephrine	54-65	renin	Canis lupus familiaris	92-97
6298402-2	1983	Intrarenal infusions of norepinephrine and epinephrine at doses adjusted to reduce renal blood flow by 20 and 50% of baseline values elicited renin release that was not completely blocked by either alpha adrenoceptor blockade with phentolamine or beta adrenoceptor blockade with propranolol.	Epinephrine	27-38	renin	Canis lupus familiaris	142-147
6222267-7	1983	Phenylethanolamine N-methyltransferase, the enzyme responsible for converting noradrenaline to adrenaline, is shown to be inhibited in vivo by p-chlorophenylalanine and in vitro by its metabolite, p-chlorophenylethylamine.	Epinephrine	81-91	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
6379758-4	1984	NPY greatly enhanced the adrenergically mediate contractile response to electrical stimulation and to application of adrenaline, noradrenaline or histamine, as studied in the isolated rabbit gastro-epiploic and femoral arteries.	Epinephrine	117-127	neuropeptide Y	Oryctolagus cuniculus	0-3
6130979-1	1983	Epinephrine, norepinephrine and isoproterenol completely inhibited insulin-stimulated 2-deoxyglucose uptake by rat adipocytes, but only when adenosine was prevented from accumulating in the incubation medium by addition of adenosine deaminase.	Epinephrine	0-11	adenosine deaminase	Rattus norvegicus	223-242
6296099-8	1983	It was concluded that insulin opposed the action of glucagon and epinephrine by affecting the phosphorylation state of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase.	Epinephrine	65-76	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	Rattus norvegicus	119-171
6824696-5	1983	These results suggest that dopamine, norepinephrine and epinephrine may serve as physiological regulators of mammalian dihydropteridine reductase.	Epinephrine	40-51	quinoid dihydropteridine reductase	Homo sapiens	119-145
6841355-4	1983	With this endogenous substrate, epinephrine elicited lipolysis with either hormone-sensitive lipase or lipoprotein lipase, but no cyclic AMP-protein kinase mediated stimulation of lipolysis was observed.	Epinephrine	32-43	lipoprotein lipase	Homo sapiens	103-121
6339003-2	1983	Systemic or intraventricular administration of insulin had no effect on catecholamine levels, but increased the turnover rate of norepinephrine and epinephrine.	Epinephrine	132-143	insulin	Homo sapiens	47-54
6339003-3	1983	Insulin induced a dose-related increased release of norepinephrine, epinephrine and dopamine from hypothalamic slices.	Epinephrine	55-66	insulin	Homo sapiens	0-7
6341134-0	1983	Differences between the effects of adrenaline and noradrenaline on insulin secretion in the dog.	Epinephrine	35-45	insulin	Canis lupus familiaris	67-74
6341134-7	1983	In hyperglycaemic dogs, adrenaline (2 micrograms X kg-1 X min-1) reduced the insulin response and enhanced the hyperglycaemia; noradrenaline (2 micrograms X kg-1 X min-1) markedly increased the insulin response (+ 2250%) without any significant change in blood glucose.	Epinephrine	24-34	insulin	Canis lupus familiaris	77-84
6341134-7	1983	In hyperglycaemic dogs, adrenaline (2 micrograms X kg-1 X min-1) reduced the insulin response and enhanced the hyperglycaemia; noradrenaline (2 micrograms X kg-1 X min-1) markedly increased the insulin response (+ 2250%) without any significant change in blood glucose.	Epinephrine	24-34	insulin	Canis lupus familiaris	194-201
6341134-9	1983	These findings show that, in the normal dog, adrenaline and noradrenaline infusions can produce opposite effects on insulin response depending on the experimental conditions.	Epinephrine	45-55	insulin	Canis lupus familiaris	116-123
6826683-0	1983	Sensitive and specific radioenzymatic assay for norepinephrine, epinephrine and dopamine based on the thin-layer chromatographic separation of their Dns-O-methyl derivatives.	Epinephrine	51-62	dysplastic nevus syndrome	Homo sapiens	149-152
6823202-3	1983	In three patients with duodenal ulcer an insulin test resulted in a 25-fold rise in plasma adrenaline.	Epinephrine	91-101	insulin	Homo sapiens	41-48
6301454-1	1983	The ability of epinephrine to potentiate the action of corticotropin-releasing factor (CRF) was studied in rat anterior pituitary cells in primary culture.	Epinephrine	15-26	corticotropin releasing hormone	Rattus norvegicus	55-85
6826683-1	1983	A radioenzymatic assay is described in which norepinephrine, epinephrine and dopamine are converted to their tritiated 3-O-methyl derivatives by reaction with S-[methyl-3H]adenosyl-L-methionine in the presence of catechol-O-methyltransferase.	Epinephrine	48-59	catechol-O-methyltransferase	Homo sapiens	213-241
6318517-1	1983	Under in vitro conditions adrenaline and noradrenaline can stimulate the production of cyclic AMP in rat corpora lutea to a similar extent as a maximal dose of LH.	Epinephrine	26-36	transmembrane serine protease 5	Rattus norvegicus	94-97
6192689-0	1983	Increased beta-thromboglobulin in essential hypertension: interactions between arterial plasma adrenaline, platelet function and blood lipids.	Epinephrine	95-105	pro-platelet basic protein	Homo sapiens	10-30
6351521-4	1983	It was found that insulin, but not modified sham feeding, caused a marked increase in plasma adrenaline and noradrenaline concentrations whereas gastric acid secretion was of a similar magnitude in the two tests.	Epinephrine	93-103	insulin	Homo sapiens	18-25
6615246-5	1983	Very low density lipoprotein and low density lipoprotein increased thrombin-induced platelet aggregation and [14C] serotonin release induced by epinephrine, ADP, and thrombin.	Epinephrine	144-155	coagulation factor II, thrombin	Homo sapiens	67-75
6135409-5	1983	Adrenaline-induced mucin secretion was inhibited by propranolol, but not by tolazoline.	Epinephrine	0-10	mucin	Canis lupus familiaris	19-24
6085824-5	1983	Theophylline and adrenaline treatment of the cell cultures also led to a 2-to 3-fold fall of the activity of the phosphodiesterase of 2",5"-oligoadenylate (2"-phosphodiesterase).	Epinephrine	17-27	phosphodiesterase 12	Mus musculus	156-176
6085824-7	1983	In the case of adrenaline, the fall of 2"-phosphodiesterase activity was accompanied by at least 5-fold increase in the enzyme activity which did not occur if actinomycin D was present in the culture.	Epinephrine	15-25	phosphodiesterase 12	Mus musculus	39-59
6186863-0	1983	Inhibitory effect of circulating norepinephrine on epinephrine-induced renin secretion.	Epinephrine	36-47	renin	Rattus norvegicus	71-76
6291915-0	1983	Plasma renin activity during infusion of epinephrine into the celiac and superior mesenteric arteries in dogs.	Epinephrine	41-52	renin	Canis lupus familiaris	7-12
6336619-1	1983	We have examined the plasma human pancreatic polypeptide (hPP) response to beta-adrenergic (infusion of epinephrine-phentolamine), vagal cholinergic, (insulin-hypoglycemia), and extravagal cholinergic (secretion infusion) stimulation in healthy, nonobese, age-matched males and females.	Epinephrine	104-115	pancreatic polypeptide	Homo sapiens	34-56
6871292-2	1983	On the basis of previous studies suggesting relatively accelerated adrenal maturation in the female rabbit fetus, we conducted an ontogenetic study of male-female differences in adrenal levels of phenylethanolamine N-methyltransferase (PNMT), the terminal enzyme in epinephrine biosynthesis.	Epinephrine	266-277	phenylethanolamine N-methyltransferase	Oryctolagus cuniculus	196-234
6404691-0	1983	Harding-passey mouse-melanoma tyrosinase inactivation by reaction products and activation by L-epinephrine.	Epinephrine	93-106	tyrosinase	Mus musculus	30-40
6664256-6	1983	These results indicate the co-existence of met-enkephalin, leu-enkephalin, met-enkephalin-Arg-Phe, met-enkephalin-Arg-Gly-Leu and their high molecular weight forms derived from preproenkephalin A in human pheochromocytomas and suggest the association of preproenkephalin A synthesis with epinephrine production in human pheochromocytomas.	Epinephrine	288-299	proopiomelanocortin	Homo sapiens	43-57
6674655-5	1983	The adrenomedullary hormone signaling the presence of adrenomedullary activity to the vasopressin releasing mechanism was identified as noradrenaline and not adrenaline.	Epinephrine	139-149	arginine vasopressin	Rattus norvegicus	86-97
6138754-1	1983	It has been found that ATP-ase activity increases considerably in the heart after intravenous administration of adrenaline, noradrenaline, phenylephrine (50 micrograms/kg), phentolamine, atropine, and also after vagotomy and adrenaline given after vagotomy.	Epinephrine	112-122	dynein axonemal heavy chain 8	Homo sapiens	23-30
6312245-2	1983	We have found that perfusion of the rat heart with epinephrine, 3-isobutyl-1-methylxanthine, or dibutyryl (Bt2) cyclic AMP produced a biphasic effect on the activity of an enzyme having the properties of the intracellular fraction of lipoprotein lipase, i.e., stability in acetone:ether, pH optimum of 8.1, serum requirement, and sensitivity to heparin, NaCl, and protamine sulfate.	Epinephrine	51-62	lipoprotein lipase	Rattus norvegicus	234-252
6306616-4	1983	Simultaneous intracisternal administration of angiotensin II 1.0 nmol together with synthetic human beta-endorphin 1.45 nmol potentiated the plasma epinephrine, norepinephrine and dopamine responses to intracisternal beta-endorphin.	Epinephrine	148-159	angiotensinogen	Homo sapiens	46-60
6306616-4	1983	Simultaneous intracisternal administration of angiotensin II 1.0 nmol together with synthetic human beta-endorphin 1.45 nmol potentiated the plasma epinephrine, norepinephrine and dopamine responses to intracisternal beta-endorphin.	Epinephrine	148-159	proopiomelanocortin	Homo sapiens	100-114
6306616-5	1983	In contrast, simultaneous intracisternal administration of the angiotensin II antagonist, [Sar1, Val5, Ala8]-angiotensin II (saralasin), 1.1 nmol together with beta-endorphin, blunted the plasma epinephrine, norepinephrine and dopamine responses to beta-endorphin.	Epinephrine	195-206	angiotensinogen	Homo sapiens	63-77
6306616-5	1983	In contrast, simultaneous intracisternal administration of the angiotensin II antagonist, [Sar1, Val5, Ala8]-angiotensin II (saralasin), 1.1 nmol together with beta-endorphin, blunted the plasma epinephrine, norepinephrine and dopamine responses to beta-endorphin.	Epinephrine	195-206	angiotensinogen	Homo sapiens	109-123
6138754-1	1983	It has been found that ATP-ase activity increases considerably in the heart after intravenous administration of adrenaline, noradrenaline, phenylephrine (50 micrograms/kg), phentolamine, atropine, and also after vagotomy and adrenaline given after vagotomy.	Epinephrine	127-137	dynein axonemal heavy chain 8	Homo sapiens	23-30
6138754-2	1983	In the skeletal muscle ATP-ase activity increases considerably after noradrenaline, isoprenaline, phenylephrine (50 micrograms/kg), adrenaline given after phentolanine and Ach given after denervation of the muscle.	Epinephrine	72-82	dynein axonemal heavy chain 8	Homo sapiens	23-30
7128025-2	1982	Phenylethanolamine N-methyltransferase (PNMT) converts noradrenaline into adrenaline and brain PNMT is elevated in spontaneously hypertensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.	Epinephrine	58-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-38
6308701-2	1983	In task 1, saline control animals showed good retention in a test session carried out 24 hr later; beta-endorphin, ACTH and epinephrine caused amnesia; beta-endorphin potentiated the amnesic effect of ACTH and epinephrine; and naloxone caused memory facilitation and reversed the amnesic effect of ACTH and epinephrine.	Epinephrine	210-221	proopiomelanocortin	Homo sapiens	152-166
6308701-2	1983	In task 1, saline control animals showed good retention in a test session carried out 24 hr later; beta-endorphin, ACTH and epinephrine caused amnesia; beta-endorphin potentiated the amnesic effect of ACTH and epinephrine; and naloxone caused memory facilitation and reversed the amnesic effect of ACTH and epinephrine.	Epinephrine	210-221	proopiomelanocortin	Homo sapiens	152-166
6308701-5	1983	On the basis of these and previous data it seems likely that the amnesic effect of ACTH and epinephrine could be mediated by endogenous beta-endorphin release.	Epinephrine	92-103	proopiomelanocortin	Homo sapiens	136-150
7164947-0	1982	Platelet-activating factor (PAF-acether): thromboxane-independent synergism with adrenaline on human platelets and recent insights into its mode of action.	Epinephrine	81-91	PCNA clamp associated factor	Homo sapiens	28-31
7128025-2	1982	Phenylethanolamine N-methyltransferase (PNMT) converts noradrenaline into adrenaline and brain PNMT is elevated in spontaneously hypertensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.	Epinephrine	58-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-44
6142061-5	1982	Perikarya labeled with PNMT, used in the biosynthesis of adrenaline, were localized in more restricted regions corresponding to rostral subsets of the dorsal and ventral groups labeled for TH and DBH.	Epinephrine	57-67	phenylethanolamine-N-methyltransferase	Rattus norvegicus	23-27
7128025-2	1982	Phenylethanolamine N-methyltransferase (PNMT) converts noradrenaline into adrenaline and brain PNMT is elevated in spontaneously hypertensive and deoxycorticosterone acetate (DOCA)-salt hypertensive rats.	Epinephrine	58-68	phenylethanolamine-N-methyltransferase	Rattus norvegicus	95-99
6142061-12	1982	Thus most, if not all, of the catecholaminergic neurons in the rostral medulla have PNMT, necessary for the synthesis of adrenaline.	Epinephrine	121-131	phenylethanolamine-N-methyltransferase	Rattus norvegicus	84-88
7172441-0	1982	Radioenzymatic assay of plasma adrenaline and noradrenaline: evidence for a catechol-O-methyltransferase (COMT) inhibiting factor associated with essential hypertension.	Epinephrine	31-41	catechol-O-methyltransferase	Homo sapiens	76-104
7155675-1	1982	Employing a perifusion technique, the activity of hormone-sensitive lipase (HSL) in human adipose tissue and isolated adipocytes was found to be significantly stimulated by 5 microM epinephrine (5-fold.	Epinephrine	182-193	lipase E, hormone sensitive type	Homo sapiens	50-74
7155675-1	1982	Employing a perifusion technique, the activity of hormone-sensitive lipase (HSL) in human adipose tissue and isolated adipocytes was found to be significantly stimulated by 5 microM epinephrine (5-fold.	Epinephrine	182-193	lipase E, hormone sensitive type	Homo sapiens	76-79
7172441-0	1982	Radioenzymatic assay of plasma adrenaline and noradrenaline: evidence for a catechol-O-methyltransferase (COMT) inhibiting factor associated with essential hypertension.	Epinephrine	31-41	catechol-O-methyltransferase	Homo sapiens	106-110
7181207-8	1982	At 60 minutes after epinephrine was given to awake, SPX cats, intravascular fluid influx of 4 ml/kg resulted in a decrease of PCV and PP.	Epinephrine	20-31	spexin hormone	Felis catus	52-55
6753559-6	1982	Also, adrenaline evoked a milder (p less than 0.01) potentiation of aggregation by thrombin of the washed platelet suspensions in the sulfinpyrazone versus the placebo group.	Epinephrine	6-16	coagulation factor II, thrombin	Homo sapiens	83-91
6765549-0	1982	Less pronounced changes in serum potassium and epinephrine during hypoglycemia induced by human insulin (recombinant DNA).	Epinephrine	47-58	insulin	Homo sapiens	96-103
6129126-3	1982	Norepinephrine, epinephrine and clonidine, but not methoxamine and phenylephrine inhibited ACTH secretion.	Epinephrine	3-14	proopiomelanocortin	Canis lupus familiaris	91-95
6765549-3	1982	Following human insulin, hypokalemia and epinephrine secretion were significantly less pronounced.	Epinephrine	41-52	insulin	Homo sapiens	16-23
6765549-4	1982	The differences in serum potassium concentrations are caused by a lower epinephrine response to hypoglycemia induced by human insulin in comparison to purified porcine insulin.	Epinephrine	72-83	insulin	Homo sapiens	126-133
6127404-10	1982	Elevation of plasma epinephrine did not result from the low arterial pressure level associated with urethane anesthesia since the increase of this parameter with vasopressin did not abolish the effect of urethane.	Epinephrine	20-31	arginine vasopressin	Rattus norvegicus	162-173
7155129-6	1982	Moderate but significant correlations have been demonstrated between sets of de novo substituent constants related to inhibition of uptake1, uptake2, phenyl-N-methyltransferase (PNMT), and of the pressor activity of epinephrine as well as for those extracted from potencies of substrates of PNMT.	Epinephrine	216-227	phenylethanolamine N-methyltransferase	Homo sapiens	178-182
7131293-5	1982	All of the phenylethanolamine N-methyltransferase inhibitors tested lowered hypothalamic epinephrine content which in spontaneously hypertensive rats could be correlated with the reduction in blood pressure.	Epinephrine	89-100	phenylethanolamine-N-methyltransferase	Rattus norvegicus	11-49
7131293-7	1982	The results also suggest the hypothesis that the blood pressure lowering effects of phenylethanolamine N-methyltransferase inhibitors may be mediated by their effects on hypothalamic epinephrine content.	Epinephrine	183-194	phenylethanolamine-N-methyltransferase	Rattus norvegicus	84-122
7155129-6	1982	Moderate but significant correlations have been demonstrated between sets of de novo substituent constants related to inhibition of uptake1, uptake2, phenyl-N-methyltransferase (PNMT), and of the pressor activity of epinephrine as well as for those extracted from potencies of substrates of PNMT.	Epinephrine	216-227	phenylethanolamine N-methyltransferase	Homo sapiens	291-295
6294746-2	1982	Likewise, synthesis of PGE and PGF was stimulated by epinephrine (3 X 10(-7) to 3 X 10(-6) M) in tissues and media from in vitro incubations of intact rat seminal vesicles.	Epinephrine	53-64	placental growth factor	Rattus norvegicus	31-34
6293615-3	1982	Addition of adrenaline entailed an increase in the level of FR and a lowering of the ceruloplasmin signal intensity in plasma.	Epinephrine	12-22	ceruloplasmin	Homo sapiens	85-98
7132734-0	1982	Action of L-epinephrine on the renin-aldosterone system and on urinary electrolyte excretion in man.	Epinephrine	10-23	renin	Homo sapiens	31-36
7132734-1	1982	The effect of L-epinephrine infusions (0.5-6.5 micrograms/min for up to 24 hr) in recumbency, on the renin-aldosterone system was studied in normal volunteers on diets containing 200 mEq sodium.	Epinephrine	14-27	renin	Homo sapiens	101-106
7132734-4	1982	In separate experiments, epinephrine lowered serum K, raised serum Na, raised plasma renin activity and, usually lowered plasma aldosterone concentrations.	Epinephrine	25-36	renin	Homo sapiens	85-90
6754494-8	1982	The endogenous insulin secretion (C-peptide) was inhibited by epinephrine and propranolol in controls and subjects with IGT irrespective of a low (6 mg .	Epinephrine	62-73	insulin	Homo sapiens	15-22
6817343-7	1982	Epinephrine at concentrations which did not cause aggregation turned on the mechanism of membrane modulation in refractory platelets and restored their sensitivity to PAF.	Epinephrine	0-11	PCNA clamp associated factor	Homo sapiens	167-170
6754494-18	1982	In conclusion, our results have confirmed the validity of an infusion technique of glucose, insulin, epinephrine and propranolol for evaluation of insulin sensitivity in vivo.	Epinephrine	101-112	insulin	Homo sapiens	147-154
7049625-3	1982	Alpha-adrenergic stimulation (epinephrine + propranolol) significantly reduced the GIP response (P less than 0.02) and completely inhibited the insulin response (P less than 0.005) to oral glucose, compared with control experiments.	Epinephrine	30-41	gastric inhibitory polypeptide	Homo sapiens	83-86
7049676-1	1982	Corticotropin-releasing factor (CRF) injected into the brains of rats produces hyperglycemia and an increase in plasma concentrations of glucagon, epinephrine, and norepinephrine.	Epinephrine	147-158	corticotropin releasing hormone	Rattus norvegicus	0-30
7049678-0	1982	Plasma renin activity during infusion of epinephrine into the carotid and vertebral arteries of anesthetized dogs.	Epinephrine	41-52	renin	Canis lupus familiaris	7-12
6813995-2	1982	Aggregation to collagen, calcium ionophore A23187 and thrombin (low doses) were often markedly inhibited by ethanol, adrenaline and ADP responses were little affected, and aggregation to exogenous arachidonic acid was actually potentiated by ethanol.	Epinephrine	117-127	coagulation factor II, thrombin	Homo sapiens	54-62
7178654-1	1982	Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats.	Epinephrine	108-119	phenylethanolamine-N-methyltransferase	Rattus norvegicus	14-52
7178654-1	1982	Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats.	Epinephrine	108-119	phenylethanolamine-N-methyltransferase	Rattus norvegicus	54-58
7178654-1	1982	Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats.	Epinephrine	121-124	phenylethanolamine-N-methyltransferase	Rattus norvegicus	14-52
7178654-1	1982	Inhibitors of phenylethanolamine N-methyltransferase (PNMT) were found to reduce hypothalamic and brainstem epinephrine (Epi) content, as well as the body temperature of male Sprague-Dawley rats.	Epinephrine	121-124	phenylethanolamine-N-methyltransferase	Rattus norvegicus	54-58
6127588-4	1982	Alpha-2 adrenergic activation, achieved with 10 muM epinephrine and 30 muM propranolol, significantly inhibited forskolin-stimulated cyclic AMP accumulation and glycerol release, shifting the dose-response curves to the right.	Epinephrine	52-63	latexin	Homo sapiens	48-51
6127586-2	1982	The beta-adrenoceptors had some of the characteristics of mammalian beta 2-adrenoceptors in that (i) adrenaline was more potent than noradrenaline and (ii) the pA2 values of two selection beta-adrenoceptor antagonists, atenolol (pA2 = 5.84) and alpha-methylpropranolol (pA2 = 8.42), were close to the values reported on beta 2-adrenoceptors in mammalian tissues.	Epinephrine	101-111	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	68-74
6291507-6	1982	gamma-Butyrobetaine hydroxylase was inhibited by a number of low-molecular-weight compounds, such as tetranitromethane, Nitro Blue Tetrazolium, adrenaline and Tiron, which may act as scavengers of superoxide anion.	Epinephrine	144-154	gamma-butyrobetaine hydroxylase 1	Homo sapiens	0-31
6127586-2	1982	The beta-adrenoceptors had some of the characteristics of mammalian beta 2-adrenoceptors in that (i) adrenaline was more potent than noradrenaline and (ii) the pA2 values of two selection beta-adrenoceptor antagonists, atenolol (pA2 = 5.84) and alpha-methylpropranolol (pA2 = 8.42), were close to the values reported on beta 2-adrenoceptors in mammalian tissues.	Epinephrine	101-111	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	320-326
6127586-4	1982	Also the pA2 value for the beta 2-selective antagonist, ICI 118,551 (7.89, adrenaline as agonist) was lower than its reported pA2 on beta 2-adrenoceptors in mammalian tissues.	Epinephrine	75-85	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	27-33
6812571-12	1982	The results are consistent with the action of a Ca2+-selective ionophore in the mechanism by which adrenaline induces the release of Ca2+ from mitochondria in the liver cell and indicate that it is unlikely that arachidonic  acid or a metabolite of arachidonic acid is involved in this process.	Epinephrine	99-109	carbonic anhydrase 2	Homo sapiens	48-51
6761206-3	1982	Rats, 1 1/2 and 12 mo of age, were infused with 2.5, 5.0, and 10.0 mU/kg of insulin during a 180-min period in which endogenous insulin secretion was suppressed by epinephrine and propranolol.	Epinephrine	164-175	insulin	Homo sapiens	128-135
6761206-5	1982	Similar results were seen in man; significant correlations were observed between height of steady-state plasma insulin concentration and advancing age during infusion of exogenous insulin and suppression of endogenous insulin with either exogenous insulin (r = 0.66, P less than 0.001) or epinephrine and propranolol (r = 0.47, P less than 0.01).	Epinephrine	289-300	insulin	Homo sapiens	111-118
6761206-5	1982	Similar results were seen in man; significant correlations were observed between height of steady-state plasma insulin concentration and advancing age during infusion of exogenous insulin and suppression of endogenous insulin with either exogenous insulin (r = 0.66, P less than 0.001) or epinephrine and propranolol (r = 0.47, P less than 0.01).	Epinephrine	289-300	insulin	Homo sapiens	180-187
6761206-5	1982	Similar results were seen in man; significant correlations were observed between height of steady-state plasma insulin concentration and advancing age during infusion of exogenous insulin and suppression of endogenous insulin with either exogenous insulin (r = 0.66, P less than 0.001) or epinephrine and propranolol (r = 0.47, P less than 0.01).	Epinephrine	289-300	insulin	Homo sapiens	180-187
6761206-5	1982	Similar results were seen in man; significant correlations were observed between height of steady-state plasma insulin concentration and advancing age during infusion of exogenous insulin and suppression of endogenous insulin with either exogenous insulin (r = 0.66, P less than 0.001) or epinephrine and propranolol (r = 0.47, P less than 0.01).	Epinephrine	289-300	insulin	Homo sapiens	180-187
6812571-12	1982	The results are consistent with the action of a Ca2+-selective ionophore in the mechanism by which adrenaline induces the release of Ca2+ from mitochondria in the liver cell and indicate that it is unlikely that arachidonic  acid or a metabolite of arachidonic acid is involved in this process.	Epinephrine	99-109	carbonic anhydrase 2	Homo sapiens	133-136
7104386-5	1982	Glucagon, epinephrine, norepinephrine, isoproterenol and phenylephrine each increases significantly glycogen phosphorylase a activity and decreases significantly the pyruvate kinase activity ratio (assayed with 0.8 mM phosphoenolpyruvate +/- 200 microM fructose 1,6-bisphosphate) in hepatocytes from both juvenile and adult rabbits.	Epinephrine	10-21	pyruvate kinase PKLR	Oryctolagus cuniculus	166-181
6282365-0	1982	Induction of human platelet fibrinogen receptors by epinephrine in the absence of released ADP.	Epinephrine	52-63	fibrinogen beta chain	Homo sapiens	28-38
6751023-3	1982	Furthermore, the appearance of insulin in arterial plasma was measured after inhibiting the endogenous insulin secretion of the pigs by epinephrine and propanolol.	Epinephrine	136-147	insulin	Sus scrofa	31-38
6751023-3	1982	Furthermore, the appearance of insulin in arterial plasma was measured after inhibiting the endogenous insulin secretion of the pigs by epinephrine and propanolol.	Epinephrine	136-147	insulin	Sus scrofa	103-110
6282365-1	1982	The ability of epinephrine to expose platelet fibrinogen receptors independent of released ADP was assessed using aspirin-treated, gel-filtered platelets.	Epinephrine	15-26	fibrinogen beta chain	Homo sapiens	46-56
6282365-2	1982	Similar to ADP-induced aggregation, platelet aggregation in response to epinephrine was accompanied by fibrinogen binding.	Epinephrine	72-83	fibrinogen beta chain	Homo sapiens	103-113
6282365-3	1982	Ten micromolar epinephrine induced a maximum number of platelet fibrinogen receptors in the absence of significant 14C-serotonin release.	Epinephrine	15-26	fibrinogen beta chain	Homo sapiens	64-74
6282365-4	1982	As indicated by Scatchard analysis, receptors exposed by both epinephrine and ADP had similar affinities for fibrinogen, but epinephrine induced approximately 30% fewer receptors than did ADP.	Epinephrine	62-73	fibrinogen beta chain	Homo sapiens	109-119
6282365-6	1982	Studies using phentolamine, a specific alpha-adrenergic antagonist, apyrase, or creatine phosphate/creatine kinase indicate that the exposure of platelet fibrinogen receptors by epinephrine was specific for platelet alpha-adrenergic receptor stimulation and was not the result of released ADP.	Epinephrine	178-189	fibrinogen beta chain	Homo sapiens	154-164
6761199-4	1982	The intensification of insulin-induced hypokalemia by epinephrine is of clinical significance.	Epinephrine	54-65	insulin	Homo sapiens	23-30
6290561-2	1982	The effects of hormones, hydrocortisone, cortin, prostaglandin E2 (PGE2), insulin, and triiodothyronine, on the release of adrenaline (A) and noradrenaline (NA) into the superfusate of the inferior mesenteric ganglion (IMG) of the dog were studied in rest and during 3 stimulations: (1) electrical stimulation of lumbar splanchnic and (2) hypogastric nerves; and (3) after acetylcholine application.	Epinephrine	123-133	insulin	Canis lupus familiaris	74-81
6282573-4	1982	When dopamine receptors were blocked with domperidone, PRL secretion was also stimulated by l-epinephrine (E) and l-norepinephrine (NE), the rank order of potency being l-ISO greater than E much greater than NE.	Epinephrine	92-105	prolactin	Homo sapiens	55-58
6283902-1	1982	Parathyroid hormone- (PTH) stimulated adenylate cyclase activity in homogenates of rat renal cortex was inhibited by l-epinephrine.	Epinephrine	117-130	parathyroid hormone	Rattus norvegicus	0-55
6283902-4	1982	The absolute decrease in adenylate cyclase activity produced by 10-4 M l-epinephrine was from 16.3 +/-0.6 (SE) to 11.2 +/- 0.6 pmol.min-1.mg-1 for activity stimulated by 10 microgram/ml PTH.	Epinephrine	71-84	parathyroid hormone	Rattus norvegicus	186-189
6124126-10	1982	The fact that epinephrine induces hyperglycemia both in physiology and diabetes could indicate an important role in enhancing glucose transport in insulin-insensitive tissues.	Epinephrine	14-25	insulin	Canis lupus familiaris	147-154
6283902-6	1982	A similar inhibition of PTH-stimulated adenylate cyclase by l-epinephrine was demonstrated in preparations of renal cortical tubules.	Epinephrine	60-73	parathyroid hormone	Rattus norvegicus	24-27
7115420-1	1982	Phenylethanolamine-N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine to epinephrine.	Epinephrine	77-88	phenylethanolamine N-methyltransferase	Bos taurus	0-38
7115420-1	1982	Phenylethanolamine-N-methyltransferase (PNMT) catalyzes the conversion of norepinephrine to epinephrine.	Epinephrine	77-88	phenylethanolamine N-methyltransferase	Bos taurus	40-44
7049777-1	1982	In six patients with chemical diabetes, insulin resistance was assessed by the steady-state plasma glucose (SSPG) level during a constant infusion of epinephrine, propranolol, glucose and insulin.	Epinephrine	150-161	insulin	Homo sapiens	40-47
7049783-2	1982	During inhibition of endogenous insulin secretion by epinephrine + propranolol, glucose infusion produced an increase in carbohydrate oxidation when plasma glucose levels reached approximately 200 mg/100 ml.	Epinephrine	53-64	insulin	Homo sapiens	32-39
6122719-4	1982	Tyramine, norepinephrine, and epinephrine also stimulate the cyclase, probably via the octopamine receptor.	Epinephrine	13-24	Octopamine-Tyramine receptor	Drosophila melanogaster	87-106
6123523-6	1982	Both plasma epinephrine and norepinephrine increased during insulin hypoglycemia, but only norepinephrine increased during insulin infusion when euglycemia was maintained.	Epinephrine	12-23	insulin	Canis lupus familiaris	60-67
6284662-6	1982	Epinephrine did not significantly influence 45Ca binding, showing an evident difference in the Ca2+ dependence of the lipolytic actions of ACTH and epinephrine.	Epinephrine	148-159	carbonic anhydrase 2	Rattus norvegicus	95-98
6809299-5	1982	A metabolic substrate mixture consisting of adenine, inosine, and fumarate (AIF) did not alter 45Ca efflux, except for antagonizing the effect of adrenaline in the presence of A23187.	Epinephrine	146-156	apoptosis inducing factor mitochondria associated 1	Homo sapiens	76-79
6809299-6	1982	Sugar transport, whether basal or stimulated by adrenaline or ascorbic acid, was significantly decreased by AIF, independently of external Ca2+.	Epinephrine	48-58	apoptosis inducing factor mitochondria associated 1	Homo sapiens	108-111
7047346-0	1982	Effect of protein-supplemented fasting on metabolic and hormonal responses to epinephrine infusion in obese subjects.	Epinephrine	78-89	insulin like growth factor binding protein 7	Homo sapiens	10-38
6126864-3	1982	Release of LHRH, somatostatin and vasopressin is affected by a variety of neurotransmitters or neuromodulators, such as norepinephrine, dopamine, epinephrine, histamine, cholinergic and opioid agonists, and peptides such as angiotensin II.	Epinephrine	123-134	gonadotropin releasing hormone 1	Homo sapiens	11-15
7043177-4	1982	The injection of insulin increased the plasma levels of epinephrine (E) and norepinephrine (NE) in both groups of subjects, but the raise in E was greater in the trained subjects.	Epinephrine	56-67	insulin	Homo sapiens	17-24
6126864-3	1982	Release of LHRH, somatostatin and vasopressin is affected by a variety of neurotransmitters or neuromodulators, such as norepinephrine, dopamine, epinephrine, histamine, cholinergic and opioid agonists, and peptides such as angiotensin II.	Epinephrine	123-134	arginine vasopressin	Homo sapiens	34-45
6952940-2	1982	When swine granulosa cells were cultured in chemically defined medium selectively deficient in Ca2+, the dose-dependent stimulation of ornithine decarboxylase (EC 4.1.1.17) activity in response to prostaglandin E2, L-epinephrine or the somatomedin, multiplication-stimulating activity, was attenuated markedly.	Epinephrine	215-228	ornithine decarboxylase 1	Sus scrofa	135-158
7112508-1	1982	Using a platelet-rich plasma (PRP) preparation, platelets from subjects with familial hypercholesterolemia (FH) were found to be more reactive to the aggregating agents epinephrine, ADP and thrombin than platelets obtained from normal individuals.	Epinephrine	169-180	low density lipoprotein receptor	Homo sapiens	77-106
7112508-1	1982	Using a platelet-rich plasma (PRP) preparation, platelets from subjects with familial hypercholesterolemia (FH) were found to be more reactive to the aggregating agents epinephrine, ADP and thrombin than platelets obtained from normal individuals.	Epinephrine	169-180	low density lipoprotein receptor	Homo sapiens	108-110
6291334-3	1982	Similarly adrenaline, both a beta- and an alpha-agonist, contracted the trachea, bronchus and parenchymal strip, but neither contracted nor relaxed the bronchiole.	Epinephrine	10-20	amyloid beta precursor protein	Rattus norvegicus	27-33
6282327-9	1982	Binding of [125I]CYP and [125I]HBP is stereospecifically inhibited by propranolol and epinephrine; the (-) stereoisomers are at least 50-times more potent than the (+) stereoisomers.	Epinephrine	86-97	heme binding protein 1	Homo sapiens	31-34
7082704-0	1982	Dopamine-beta-hydroxylase response to epinephrine injection in anxious patients and normals.	Epinephrine	38-49	dopamine beta-hydroxylase	Homo sapiens	0-25
6280179-2	1982	In addition, exposure of intact platelets to clonidine-NCS, followed by extensive washing, results in the loss of of epinephrine-induced inhibition of adenylate cyclase activity [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in frozen--thawed platelets and in purified platelet membranes.	Epinephrine	117-128	adenylate cyclase 10	Homo sapiens	179-202
7042427-0	1982	Insulin absorption from the abdomen and the thigh in healthy subjects during rest and exercise: blood glucose, plasma insulin, growth hormone, adrenaline and noradrenaline levels.	Epinephrine	143-153	insulin	Homo sapiens	0-7
6281092-2	1982	Adrenaline and D2O reduced the interaction between ADH and its receptors.	Epinephrine	0-10	arginine vasopressin	Homo sapiens	51-54
6120181-0	1982	Role of epinephrine-mediated beta-adrenergic mechanisms in hypoglycemic glucose counterregulation and posthypoglycemic hyperglycemia in insulin-dependent diabetes mellitus.	Epinephrine	8-19	insulin	Homo sapiens	136-143
7055707-2	1982	Secretion of adrenaline was accompanied by that of dopamine-beta-hydroxylase showing the exocytotic nature, 2,4,5-Trinitrophenol, which is devoid of uncoupling activity, and other nitrophenol compounds were also effective in inducing secretion, suggesting that secretion by nitrophenol compound is due to increased Ca entry through its direct effect on the plasma membrane.	Epinephrine	13-23	dopamine beta-hydroxylase	Oryctolagus cuniculus	51-76
7035494-13	1982	It is concluded that (a) the splanchnic bed accounts for one-third of total body glucose uptake in the basal state in normal humans; (b) epinephrine markedly inhibits the rise in splanchnic glucose uptake induced by infusion of glucose; and (c) this effect does not require a fall in insulin and is modulated by the level of hyperglycemia.	Epinephrine	137-148	insulin	Homo sapiens	284-291
6127782-4	1982	Plasma adrenaline levels increased significantly during selective beta-1-adrenoceptor blockade.	Epinephrine	7-17	adrenoceptor beta 1	Homo sapiens	66-85
6301325-7	1982	The sympathetic nervous system has multiple points of interdigitation in both the kallikrein-kinin and the renin-angiotensin systems; high levels of epinephrine stimulate renin release and activate both plasma and tissue kallikrein.	Epinephrine	149-160	renin	Ovis aries	107-112
6976501-1	1982	Corticotropin-releasing factor administered intracerebroventricularly produces prolonged elevation of plasma concentration of epinephrine, norepinephrine and glucose.	Epinephrine	126-137	corticotropin releasing hormone	Homo sapiens	0-30
6301325-7	1982	The sympathetic nervous system has multiple points of interdigitation in both the kallikrein-kinin and the renin-angiotensin systems; high levels of epinephrine stimulate renin release and activate both plasma and tissue kallikrein.	Epinephrine	149-160	renin	Ovis aries	171-176
6219630-4	1982	These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.	Epinephrine	43-54	kininogen 1	Homo sapiens	66-76
6805416-3	1982	Epinephrine neuronal systems might play a part in some pharmacologic actions of MAO inhibitors and uptake inhibitors as well as alpha and beta agonists and antagonists.	Epinephrine	0-11	monoamine oxidase A	Rattus norvegicus	80-83
6805416-4	1982	PNMT inhibitors currently represent the only means of modifying epinephrine neurons pharmacologically without also altering norepinephrine or dopamine neurons in brain.	Epinephrine	64-75	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-4
6280799-5	1982	3 alpha-MSH dose-response curves were shifted, in parallel, to the right in the presence of the catecholamines, noradrenaline, adrenaline and dopamine, and Lineweaver-Burke plots and Arunlakshana-Schild plots indicated that the catecholamines antagonized MSH action by a competitive mechanism.	Epinephrine	115-125	proopiomelanocortin	Homo sapiens	2-11
6280799-5	1982	3 alpha-MSH dose-response curves were shifted, in parallel, to the right in the presence of the catecholamines, noradrenaline, adrenaline and dopamine, and Lineweaver-Burke plots and Arunlakshana-Schild plots indicated that the catecholamines antagonized MSH action by a competitive mechanism.	Epinephrine	115-125	proopiomelanocortin	Homo sapiens	8-11
6762265-4	1982	Plasma epinephrine (PE) and norepinephrine (PNE) were significantly higher in the PIH than in the control and RRH groups (respectively 135 +/- 28 pg/ml versus 56 +/- 13 and 63 +/- 17 for PE and 387 +/- 91 versus 206 +/- 32 and 200 +/- 47 pg/ml for PNE).	Epinephrine	7-18	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	82-85
6186366-6	1982	Administration of adrenaline before endotoxin inhibited the elicitation of TNF and growth-inhibitory activities, which indicates tachyphylaxis.	Epinephrine	18-28	tumor necrosis factor	Mus musculus	75-78
7042239-10	1982	Infusion of adrenaline (epinephrine) in conditions in which insulin secretion was not inhibited caused only a transient increase in plasma FFA concentrations and in ketone body production.	Epinephrine	12-22	insulin	Homo sapiens	60-67
7042239-10	1982	Infusion of adrenaline (epinephrine) in conditions in which insulin secretion was not inhibited caused only a transient increase in plasma FFA concentrations and in ketone body production.	Epinephrine	24-35	insulin	Homo sapiens	60-67
7105433-1	1982	Several medullary cardiovascular relay nuclei contain high concentrations of epinephrine and phenylethanolamine-N-methyl transferase (PNMT), the enzyme which catalyzes the conversion of norepinephrine to epinephrine.	Epinephrine	189-200	phenylethanolamine-N-methyltransferase	Rattus norvegicus	93-132
6818113-0	1982	The potentiating effect of cortisone (prednisolone) on the fibrinolytic and clotting factor VIII responses to intravenous infusion of adrenaline in man.	Epinephrine	134-144	cytochrome c oxidase subunit 8A	Homo sapiens	92-96
7105433-1	1982	Several medullary cardiovascular relay nuclei contain high concentrations of epinephrine and phenylethanolamine-N-methyl transferase (PNMT), the enzyme which catalyzes the conversion of norepinephrine to epinephrine.	Epinephrine	189-200	phenylethanolamine-N-methyltransferase	Rattus norvegicus	134-138
6274613-11	1982	From these data we conclude that 1) circulating epinephrine can stimulate pituitary-adrenocortical activity, 2) this action is mediated by a beta-adrenergic receptor mechanism, and 3) such a mechanism may be involved in the response of the pituitary-adrenal axis during certain forms of stress.	Epinephrine	48-59	amyloid beta precursor protein	Rattus norvegicus	139-145
6818113-2	1982	Asthmatic patients showed greater responses of both parameters to adrenaline than controls indicating that long-term corticosteroid treatment enhances the acute responses of plasminogen activator and clotting factor VIII to adrenaline infusion.	Epinephrine	66-76	cytochrome c oxidase subunit 8A	Homo sapiens	216-220
6211399-4	1982	Both 5-hydroxy-tryptamine and beta-thromboglobulin release were greater with patients" platelets than with those of controls in response to adrenaline, ADP and U44069.	Epinephrine	140-150	pro-platelet basic protein	Homo sapiens	30-50
6818113-2	1982	Asthmatic patients showed greater responses of both parameters to adrenaline than controls indicating that long-term corticosteroid treatment enhances the acute responses of plasminogen activator and clotting factor VIII to adrenaline infusion.	Epinephrine	224-234	cytochrome c oxidase subunit 8A	Homo sapiens	216-220
6294158-0	1982	beta-Adrenergic receptors and cyclic AMP responses to epinephrine in cultured human fibroblasts at various population densities.	Epinephrine	54-65	adenine phosphoribosyltransferase	Homo sapiens	37-40
6121823-2	1982	Yohimbine, an alpha-2 adrenoceptor antagonist, markedly reduced epinephrine-stimulated 3H-glycerol uptake into phosphatidylinositol; while prazosin, an alpha-1 antagonist, was without effect.	Epinephrine	64-75	adrenoceptor alpha 1D	Homo sapiens	152-159
6813424-6	1982	In adults, the lower epinephrine levels found in women urine do not seem to result from a sex difference in the degree of adrenergic maturity, but perhaps partly from an increased rate of epinephrine inactivation by catechol-O-methyltransferase.	Epinephrine	188-199	catechol-O-methyltransferase	Homo sapiens	216-244
6813757-7	1982	It was found that intracerebroventricular pretreatment of animals with TRH, although causing no change in the epinephrine-induced pressor effect, did reduce the epinephrine-induced reflex bradycardia in rats.	Epinephrine	161-172	thyrotropin releasing hormone	Rattus norvegicus	71-74
6298888-8	1982	They also support the suggestion that epinephrine and/or norepinephrine could be involved as physiological corticotropin-releasing factor(s).	Epinephrine	38-49	corticotropin releasing hormone	Rattus norvegicus	107-137
7323441-0	1981	Phenylethanolamine-N-methyltransferase activity determines the epinephrine concentration of pheochromocytomas.	Epinephrine	63-74	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
6289369-5	1982	Epinephrine and carbachol increased plasma cyclic AMP and cyclic GMP levels, respectively, in both C57BL and DBA mice.	Epinephrine	0-11	5'-nucleotidase, cytosolic II	Mus musculus	65-68
7323441-4	1981	There was a significant correlation between PNMT activity and epinephrine concentration in the pheochromocytomas (r=0.61); there was no significant correlation between PNMT activity and norepinephrine concentration (r=0.38) or DBH activity and norepinephrine (r=0.06) or dopamine (r=0.31) concentration.	Epinephrine	62-73	phenylethanolamine N-methyltransferase	Homo sapiens	44-48
6120054-6	1981	Somatostatin suppressed the insulin response to glucagon and inhibited the insulin rebound observed on termination of adrenaline infusion.	Epinephrine	118-128	insulin	Homo sapiens	75-82
7289885-10	1981	Muscle LPL activity in the afternoon was closely related to urinary excretion of epinephrine.	Epinephrine	81-92	lipoprotein lipase	Homo sapiens	7-10
6795031-2	1981	The administration of saturating concentrations of LH, prostaglandin E2, L-epinephrine, or 8-bromo-cAMP each elicited highly significant increases in progesterone production, which correlated closely with corresponding stimulated levels of ODC activity.	Epinephrine	73-86	ornithine decarboxylase 1	Homo sapiens	240-243
7289885-13	1981	Muscle LPL activity in the afternoon was closely related to urinary excretion of epinephrine.	Epinephrine	81-92	lipoprotein lipase	Homo sapiens	7-10
7289885-16	1981	Muscle LPL activity in the afternoon was closely related to urinary excretion of epinephrine.	Epinephrine	81-92	lipoprotein lipase	Homo sapiens	7-10
7272509-0	1981	ADP and epinephrine-induced release of platelet fibrinogen.	Epinephrine	8-19	fibrinogen beta chain	Homo sapiens	48-58
7029792-4	1981	The recurring reduction was induced by epinephrine which activates phospholipase A2 and cyclo-oxygenase and causes platelet aggregation.	Epinephrine	39-50	phospholipase A2 group IB	Canis lupus familiaris	67-83
7272509-3	1981	With addition of ADP or epinephrine, biphasic aggregation was seen, with release of platelet fibrinogen, beta-thromboglobulin, and platelet factor 4.	Epinephrine	24-35	fibrinogen beta chain	Homo sapiens	93-103
7272509-3	1981	With addition of ADP or epinephrine, biphasic aggregation was seen, with release of platelet fibrinogen, beta-thromboglobulin, and platelet factor 4.	Epinephrine	24-35	pro-platelet basic protein	Homo sapiens	105-148
7272509-7	1981	The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release.	Epinephrine	58-69	fibrinogen beta chain	Homo sapiens	173-183
7272509-7	1981	The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release.	Epinephrine	58-69	fibrinogen beta chain	Homo sapiens	173-183
7272509-7	1981	The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release.	Epinephrine	250-261	fibrinogen beta chain	Homo sapiens	173-183
7272509-7	1981	The ability of gel-filtered platelets to undergo ADP- and epinephrine-induced aggregation and release in the absence of exogenous fibrinogen suggests that released platelet fibrinogen may be able to fulfill the requirement for fibrinogen in ADP- and epinephrine-induced platelet aggregation and release.	Epinephrine	250-261	fibrinogen beta chain	Homo sapiens	173-183
6270172-1	1981	In rats, adrenal medullary synthesis of epinephrine is impaired by ACTH deficiency and is not improved by replacement doses of glucocorticoid.	Epinephrine	40-51	proopiomelanocortin	Homo sapiens	67-71
7286498-6	1981	It is concluded that from the hormones investigated within this study adrenaline exerts the strongest diabetogenic action during its short term administration followed by that of growth hormone.	Epinephrine	70-80	growth hormone 1	Homo sapiens	179-193
6797089-6	1981	Ticlopidine at final concentrations of 200, 100, 50 and 25 microM inhibited both ADP and adrenaline-induced fibrinogen binding in a dose-dependent manner.	Epinephrine	89-99	fibrinogen beta chain	Homo sapiens	108-118
6457840-7	1981	The regulators of this in vitro fusion--Ca2+, synexin, and free, cis-unsaturated fatty acids--may be present in the cytoplasm of the chromaffin cell when it is stimulated to release epinephrine and granule proteins by exocytosis.	Epinephrine	182-193	annexin A7	Homo sapiens	46-53
6797089-4	1981	125I-fibrinogen binding was measured in suspensions of freshly-washed normal platelets stimulated by 10 microM ADP or 10 microM adrenaline.	Epinephrine	128-138	fibrinogen beta chain	Homo sapiens	5-15
6797089-8	1981	The mean % inhibition of adrenaline-induced fibrinogen binding was 86, 82, 60 and 35 respectively.	Epinephrine	25-35	fibrinogen beta chain	Homo sapiens	44-54
7021547-4	1981	Adenylate cyclase of islets cultured with islet-activating protein (IAP), one of the pertussis toxins, was less susceptible to epinephrine inhibition.	Epinephrine	127-138	Cd47 molecule	Rattus norvegicus	42-66
7297599-6	1981	Concentration-response curves for the inhibitory effect of NT, adrenaline and ATP indicated that NT (IC50 0.32 nM) was 100 times more potent than adrenaline (IC50 nM) and 50 000 times more potent than ATP (IC50 16 microM).	Epinephrine	63-73	neurotensin/neuromedin N	Cavia porcellus	97-99
7297599-6	1981	Concentration-response curves for the inhibitory effect of NT, adrenaline and ATP indicated that NT (IC50 0.32 nM) was 100 times more potent than adrenaline (IC50 nM) and 50 000 times more potent than ATP (IC50 16 microM).	Epinephrine	146-156	neurotensin/neuromedin N	Cavia porcellus	59-61
7035037-11	1981	PNMT enzyme activity in a cross-segment of the medulla containing the adrenaline synthesizing cells was also increased by 30% in both spontaneous hypertensive rats and stroke-prone rats.	Epinephrine	70-80	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-4
7273810-0	1981	Comparison of dopamine, dobutamine, and epinephrine in CPR.	Epinephrine	40-51	cytochrome p450 oxidoreductase	Canis lupus familiaris	55-58
6126856-3	1981	This activity was stimulated (in the presence as well as in the absence of added GTP) by D,L-isoproterenol, L-epinephrine and L-norepinephrine, the relative potency of these agonists being compatible with the existence of beta-adrenoceptors of the beta2 subtype.	Epinephrine	108-121	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	248-253
6621326-2	1983	The name of the intracellular enzyme has been changed from LPL to type L hormone-sensitive lipase (HSL) because it is responsive to epinephrine and glucagon levels in heart.	Epinephrine	132-143	lipoprotein lipase	Rattus norvegicus	59-62
6621326-2	1983	The name of the intracellular enzyme has been changed from LPL to type L hormone-sensitive lipase (HSL) because it is responsive to epinephrine and glucagon levels in heart.	Epinephrine	132-143	lipase E, hormone sensitive type	Rattus norvegicus	73-97
6621326-2	1983	The name of the intracellular enzyme has been changed from LPL to type L hormone-sensitive lipase (HSL) because it is responsive to epinephrine and glucagon levels in heart.	Epinephrine	132-143	lipase E, hormone sensitive type	Rattus norvegicus	99-102
6621326-3	1983	In this symposium evidence will show that epinephrine also activates type L HSL in skeletal muscle.	Epinephrine	42-53	lipase E, hormone sensitive type	Rattus norvegicus	76-79
7258729-3	1981	We found that 2 muM of ADP, and 9.1 and 22.7 muM of adrenalin induced statistically significant increases in nondissociative patterns of platelet aggregation in the patient group.	Epinephrine	52-61	latexin	Homo sapiens	45-48
7021547-4	1981	Adenylate cyclase of islets cultured with islet-activating protein (IAP), one of the pertussis toxins, was less susceptible to epinephrine inhibition.	Epinephrine	127-138	Cd47 molecule	Rattus norvegicus	68-71
6173039-2	1981	Adrenaline has a biphasic effect on intracellular lipoprotein lipase activity and on endogenous triacylglycerol content in heparin-perfused heart.	Epinephrine	0-10	lipoprotein lipase	Rattus norvegicus	50-68
6268188-8	1981	Glucagon, epinephrine, isoproterenol, phenylephrine and dibutyryl cyclic AMP each inhibits significantly pyruvate kinase activity in rabbit hepatocytes.	Epinephrine	10-21	pyruvate kinase PKLR	Oryctolagus cuniculus	105-120
6268188-9	1981	Inhibition of pyruvate kinase activity by epinephrine, isoproterenol or phenylephrine is negated by propranolol but insensitive to phentolamine.	Epinephrine	42-53	pyruvate kinase PKLR	Oryctolagus cuniculus	14-29
6268188-11	1981	These observations suggest that enhancement by epinephrine of glucose formation from either dihydroxyacetone or D-fructose is solely beta-adrenergic-regulated, just as is its inhibition of pyruvate kinase activity.	Epinephrine	47-58	pyruvate kinase PKLR	Oryctolagus cuniculus	189-204
6268188-12	1981	Stimulation of gluconeogenesis by glucagon, epinephrine, isoproterenol, phenylephrine or dibutyryl cyclic AMP may be at least in part directly related to their ability to inhibit pyruvate kinase.	Epinephrine	44-55	pyruvate kinase PKLR	Oryctolagus cuniculus	179-194
6173039-4	1981	A high concentration of adrenaline (1 microM in the perfusion buffer) activated endogenous lipoprotein lipase activity and, at the same time, decreased intracellular triacylglycerol stores.	Epinephrine	24-34	lipoprotein lipase	Rattus norvegicus	91-109
6173039-6	1981	In contrast, a low concentration (0.005 microM-adrenaline) inhibited intracellular lipoprotein lipase activity.	Epinephrine	47-57	lipoprotein lipase	Rattus norvegicus	83-101
6173039-11	1981	The effect of adrenaline on intracellular lipoprotein lipase activity appears to be mediated by cyclic AMP through protein kinase.	Epinephrine	14-24	lipoprotein lipase	Rattus norvegicus	42-60
6263408-2	1981	The dose-response curves for adrenaline did not correspond to simple mass action kinetics and their computer analysis suggests the presence of both beta 1- and beta 2-adrenergic-sensitive adenylate cyclase (58 plus or minus 17% and 42 plus or minus 17% respectively).	Epinephrine	29-39	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	148-154
7250533-0	1981	Cardiac arrhythmias during epinephrine-propranolol infusions for measurement of in vivo insulin resistance.	Epinephrine	27-38	insulin	Homo sapiens	88-95
6263592-0	1981	beta-Endorphin-induced stimulation of central sympathetic outflow: beta-endorphin increases plasma concentrations of epinephrine, norepinephrine, and dopamine in rats.	Epinephrine	117-128	proopiomelanocortin	Homo sapiens	67-81
6263592-1	1981	Intracisternal administration of synthetic human beta-endorphin (0.058-7.25 nmol) in chronically cannulated, conscious, freely moving, adult male rats increased plasma concentrations of epinephrine, norepinephrine, and dopamine in a dose-related manner.	Epinephrine	186-197	proopiomelanocortin	Homo sapiens	49-63
6263592-2	1981	Epinephrine secretion was the most sensitive to the stimulatory effect of intracerebral beta-endorphin; plasma epinephrine increased transiently in response to 0.058 nmol.	Epinephrine	111-122	proopiomelanocortin	Homo sapiens	88-102
6263592-8	1981	Bilateral adrenal denervation completely prevented the plasma epinephrine response to beta-endorphin and blunted the plasma norepinephrine and dopamine responses.	Epinephrine	62-73	proopiomelanocortin	Homo sapiens	86-100
6455728-1	1981	A zwitterion indole metabolite of epinephrine, an inhibitor of actomyosin ATPase, has been shown to delay or prevent superprecipitation of cardiac and skeletal muscle actomyosin in a concentration-dependent manner.	Epinephrine	34-45	dynein axonemal heavy chain 8	Homo sapiens	74-80
6263408-2	1981	The dose-response curves for adrenaline did not correspond to simple mass action kinetics and their computer analysis suggests the presence of both beta 1- and beta 2-adrenergic-sensitive adenylate cyclase (58 plus or minus 17% and 42 plus or minus 17% respectively).	Epinephrine	29-39	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	160-166
6112882-8	1981	Daily injection of quinacrine (16 mg/kg), an antimalarial agent that inhibits phospholipase A2, blocked the subsensitivity to the chronotropic effect of epinephrine, but not that to the pressor effect of epinephrine.	Epinephrine	153-164	phospholipase A2 group IB	Rattus norvegicus	78-94
6112047-0	1981	Beta-endorphin-induced increases in plasma epinephrine, norepinephrine and dopamine in rats: inhibition of adrenomedullary response by intracerebral somatostatin.	Epinephrine	43-54	proopiomelanocortin	Homo sapiens	0-14
6112047-1	1981	Synthetic human beta-endorphin, 7.25 nmol intracisternally, in unanesthetized, freely moving, chronically cannulated, adult male rats increased plasma concentrations of all 3 catecholamines: epinephrine, norepinephrine and dopamine, for the 2 h period studied.	Epinephrine	191-202	proopiomelanocortin	Homo sapiens	16-30
6112047-5	1981	Simultaneous intracisternal administration of another neuropeptide, somatostatin, together with beta-endorphin markedly inhibited the plasma epinephrine response to beta-endorphin, while decreasing the dopamine and norepinephrine responses to a much lesser degree.	Epinephrine	141-152	proopiomelanocortin	Homo sapiens	96-110
6112047-5	1981	Simultaneous intracisternal administration of another neuropeptide, somatostatin, together with beta-endorphin markedly inhibited the plasma epinephrine response to beta-endorphin, while decreasing the dopamine and norepinephrine responses to a much lesser degree.	Epinephrine	141-152	proopiomelanocortin	Homo sapiens	165-179
6274313-10	1981	Induction of glucokinase in vitro in hepatocytes from neonatal animals is inhibited by adrenaline, glucagon and dibutyryl cyclic AMP, but not by vasopressin or angiotensin II.	Epinephrine	87-97	glucokinase	Rattus norvegicus	13-24
7214955-0	1981	Comparison of dopamine, dobutamine, and epinephrine in CPR.	Epinephrine	40-51	cytochrome p450 oxidoreductase	Homo sapiens	55-58
7014307-2	1981	One method, the insulin suppression test, is performed by continuously infusing epinephrine, propranolol, insulin, and glucose.	Epinephrine	80-91	insulin	Homo sapiens	16-23
7014307-3	1981	Epinephrine and propranolol suppress endogenous insulin release, and steady-state plasma levels of exogenous insulin and glucose are reached in all individuals.	Epinephrine	0-11	insulin	Homo sapiens	48-55
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Epinephrine	72-83	prion protein	Homo sapiens	129-132
7242852-1	1981	The enzyme which converts to norepinephrine to epinephrine, phenylethanolamine N-methyltransferase (PNMT), is found in brain as well as in the adrenal medulla.	Epinephrine	32-43	phenylethanolamine-N-methyltransferase	Rattus norvegicus	60-98
7242852-1	1981	The enzyme which converts to norepinephrine to epinephrine, phenylethanolamine N-methyltransferase (PNMT), is found in brain as well as in the adrenal medulla.	Epinephrine	32-43	phenylethanolamine-N-methyltransferase	Rattus norvegicus	100-104
7244360-0	1981	Elevation of epinephrine concentration in rat brain by LY51641, a selective inhibitor of type A monoamine oxidase.	Epinephrine	13-24	monoamine oxidase A	Rattus norvegicus	96-113
7244360-2	1981	The inhibition of type A MAO was accompanied by an increase in epinephrine concentration in hypothalamus.	Epinephrine	63-74	monoamine oxidase A	Rattus norvegicus	25-28
7244360-7	1981	Two analogs of LY51641 of differing selectivity elevated epinephrine concentration to a degree related to percentage inhibition of type A MAO, and the effect of LY51641 was antagonized by pretreatment with harmaline, a short-acting reversible inhibitor of type A MAO.	Epinephrine	57-68	monoamine oxidase A	Rattus norvegicus	138-141
7244360-8	1981	These findings support earlier evidence that in rat hypothalamus, epinephrine oxidation occurs by type A not type B MAO.	Epinephrine	66-77	monoamine oxidase A	Rattus norvegicus	116-119
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Epinephrine	72-83	prion protein	Homo sapiens	161-164
6789496-4	1981	Addition of citrate restored the extent of ADP-induced secretion and of epinephrine-induced aggregation and secretion in heparin-PRP to that observed in citrate-PRP, and increased the extent of ADP-induced secretion in hirudin-PRP.	Epinephrine	72-83	prion protein	Homo sapiens	161-164
7204569-9	1981	Marked increases in epinephrine and slight increases in norepinephrine were associated with increases in plasma glucose and renin activity and decreases in plasma potassium.	Epinephrine	20-31	renin	Homo sapiens	124-129
6261845-12	1981	The plasma cyclic GMP response to subcutaneous epinephrine, suggested as a model for presynaptic alpha-noradrenergic mechanisms, is also partially inhibited by Li therapy.	Epinephrine	47-58	5'-nucleotidase, cytosolic II	Homo sapiens	18-21
7004860-7	1981	Microinjections of epinephrine and norepinephrine into the VMH also caused rises in the levels of both glucagon and insulin, although the effects of norepinephrine were much less than those of epinephrine.	Epinephrine	19-30	insulin	Oryctolagus cuniculus	116-123
7280120-5	1981	Results of the study demonstrate that aspirin-treated SPD platelets, which cannot form thromboxane or undergo the release reaction on stimulation by arachidonate, can still undergo irreversible aggregation in response to thrombin and ADP if treated first with epinephrine.	Epinephrine	260-271	coagulation factor II, thrombin	Homo sapiens	221-229
6112188-4	1981	Associated with these changes in epinephrine secretion is a reduction of plasma insulin and elevation of plasma glucagon and glucose.	Epinephrine	33-44	insulin	Homo sapiens	80-87
6260644-4	1981	These cells responded to epinephrine and norepinephrine by increasing both synthesis and release of renin.	Epinephrine	25-36	renin	Rattus norvegicus	100-105
7464918-8	1981	We report here the simultaneous localization, in the same histological section, of 3H-oestradiol and the enzyme dopamine-beta-hydroxylase in neurones of the rat lower brain stem with a combined technique of thaw-mount autoradiography and immunohistochemistry, demonstrating that noradrenaline- or adrenaline-containing neurones are oestradiol target cells.	Epinephrine	282-292	dopamine beta-hydroxylase	Rattus norvegicus	112-137
6778684-2	1981	Judging by the minimal concentration of hormone needed to produce a statistically significant response, hGH was 3-10 times as potent as Da1 and Dc2 in increasing the oxidation of [U-14C]glucose to 14CO2, hGH and Da1 were equipotent in stimulating the oxidation of L-[1-14C]leucine to 14CO2, antagonizing the lipolytic effect of epinephrine, and inducing refractoriness to the insulin-like action of hGH.	Epinephrine	328-339	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	136-139
6778684-2	1981	Judging by the minimal concentration of hormone needed to produce a statistically significant response, hGH was 3-10 times as potent as Da1 and Dc2 in increasing the oxidation of [U-14C]glucose to 14CO2, hGH and Da1 were equipotent in stimulating the oxidation of L-[1-14C]leucine to 14CO2, antagonizing the lipolytic effect of epinephrine, and inducing refractoriness to the insulin-like action of hGH.	Epinephrine	328-339	monoacylglycerol O-acyltransferase 1	Homo sapiens	144-147
6778684-2	1981	Judging by the minimal concentration of hormone needed to produce a statistically significant response, hGH was 3-10 times as potent as Da1 and Dc2 in increasing the oxidation of [U-14C]glucose to 14CO2, hGH and Da1 were equipotent in stimulating the oxidation of L-[1-14C]leucine to 14CO2, antagonizing the lipolytic effect of epinephrine, and inducing refractoriness to the insulin-like action of hGH.	Epinephrine	328-339	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	212-215
7462233-3	1981	Adenylate cyclase in the cyc- variant was also specifically desensitized by epinephrine in prostaglandin E1.	Epinephrine	76-87	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	10-13
27942815-4	1981	Associated with these changes in epinephrine secretion is a reduction of plasma insulin and elevation of plasma glucagon and glucose.	Epinephrine	33-44	insulin	Homo sapiens	80-87
7004860-7	1981	Microinjections of epinephrine and norepinephrine into the VMH also caused rises in the levels of both glucagon and insulin, although the effects of norepinephrine were much less than those of epinephrine.	Epinephrine	38-49	insulin	Oryctolagus cuniculus	116-123
7004860-9	1981	Chemical stimulation of the LHN only with epinephrine induced a preferential rise in the insulin level without any significant change in the levels of glucagon and glucose.	Epinephrine	42-53	insulin	Oryctolagus cuniculus	89-96
7248753-3	1981	Adrenal denervation blocked the beta-endorphin-induced increase in plasma glucose, supporting a thesis that this effect is mediated at least in part by increased epinephrine secretion.	Epinephrine	162-173	proopiomelanocortin	Homo sapiens	32-46
6257762-5	1981	Cells or cell membranes were incubated with epinephrine (10 muM) alone and in combination with the antagonists yohimbine (alpha-2) and prazosin (alpha-1).	Epinephrine	44-55	latexin	Homo sapiens	60-63
7008899-4	1981	The increase in counts of PNMT cell profiles in the medulla suggests that there is a genetic difference in the number of central adrenaline neurons in these hypertensive rats.	Epinephrine	129-139	phenylethanolamine-N-methyltransferase	Rattus norvegicus	26-30
7006417-3	1981	In addition, epinephrine stimulated renin secretion and its stimulatory action was blocked by ouabain.	Epinephrine	13-24	renin	Homo sapiens	36-41
7347133-1	1981	The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition.	Epinephrine	4-14	catechol-O-methyltransferase	Homo sapiens	104-132
7347133-1	1981	The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition.	Epinephrine	4-14	catechol-O-methyltransferase	Homo sapiens	134-138
6262879-3	1981	As shown by dose-response studies, VIP is by far the most effective inducer (Ka equals 4 x 10(-10) M) of the cyclic AMP phosphodiesterase activity; partial activation of the enzyme is obtained by 3 x 10(-7) M secretin, 10(-5) M isoproterenol and 10(-5) M PGE1; PGE2 and epinephrine are without effect.	Epinephrine	270-281	vasoactive intestinal peptide	Homo sapiens	35-38
6262879-4	1981	In HRT 18 cells VIP is less active (Ka equals 2 x 10(-9) M) whereas 10(-6) M PGE1, 10(-6) M PGE2 and 10(-5) M epinephrine are potent inducers of th phosphodiesterase activity.	Epinephrine	110-121	vasoactive intestinal peptide	Homo sapiens	16-19
7347133-1	1981	The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition.	Epinephrine	16-18	catechol-O-methyltransferase	Homo sapiens	104-132
7347133-1	1981	The adrenaline (AD) induced relaxation in the smooth muscle is increased by bioflavonoids, possibly via cathecol-0-methyltransferase (COMT) inhibition.	Epinephrine	16-18	catechol-O-methyltransferase	Homo sapiens	134-138
6265172-2	1981	32Pi-labelled cells respond to epinephrine by increase in labeling of a 67,000-dalton band, presumably the activated lipase.	Epinephrine	31-42	lipase G, endothelial type	Rattus norvegicus	117-123
6115746-6	1981	From these data, it appears that after 2 postnatal weeks, further developmental rise of TH activity in the sympathetic ganglion is an epinephrine-dependent process.	Epinephrine	134-145	tyrosine hydroxylase	Rattus norvegicus	88-90
6117422-9	1981	Expression of the adrenergic phenotype was apparently regulated differently from noradrenergic expression, since phenylethanolamine-N-methyltransferase (PNMT), the adrenaline-(epinephrine)-synthesizing enzyme, was undetectable in ganglion primordia and gut cells.	Epinephrine	164-174	phenylethanolamine-N-methyltransferase	Rattus norvegicus	113-151
6117422-9	1981	Expression of the adrenergic phenotype was apparently regulated differently from noradrenergic expression, since phenylethanolamine-N-methyltransferase (PNMT), the adrenaline-(epinephrine)-synthesizing enzyme, was undetectable in ganglion primordia and gut cells.	Epinephrine	176-187	phenylethanolamine-N-methyltransferase	Rattus norvegicus	113-151
7014320-5	1981	Clear-cut increments in plasma gastrin concentration were seen only on 3 participants, each of whom responded to insulin hypoglycaemia with an extremely high adrenaline release.	Epinephrine	158-168	gastrin	Homo sapiens	31-38
7029849-5	1981	However, epinephrine significantly decreased liver G6PD activity by 17%, 7.5 min, after injection.	Epinephrine	9-20	glucose-6-phosphate dehydrogenase	Rattus norvegicus	51-55
7287968-0	1981	Epinephrine desensitization of adenylate cyclase from cyc- and S49 cultured lymphoma cells.	Epinephrine	0-11	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	41-44
6118277-3	1981	There were profound differences in the metabolic profile of the two substances: the non-cardioselective beta-blocker caused significant inhibition of the lipolytic, glycogenolytic and the growth hormone-releasing effects of adrenaline when compared to the cardioselective agent.	Epinephrine	224-234	growth hormone 1	Homo sapiens	188-202
7287968-2	1981	We have previously shown that the cyc- adenylate cyclase desensitized with 1-3 hr pretreatment of the cells with the beta-adrenergic agonist epinephrine.	Epinephrine	141-152	peptidylprolyl isomerase A, pseudogene 1	Mus musculus	34-37
7029849-0	1981	The effects of alloxan diabetes, insulin and epinephrine on glucose-6-phosphate dehydrogenase from rat liver and brain.	Epinephrine	45-56	glucose-6-phosphate dehydrogenase	Rattus norvegicus	60-93
6110570-7	1980	In in vitro studies, somatostatin augmented the aggregation response to epinephrine in both normals and diabetics.	Epinephrine	72-83	somatostatin	Homo sapiens	21-33
6255805-4	1980	The lower dose of epinephrine diminished the acute insulin response (AIR) after a 20-g intravenous glucose pulse (control, 463 +/- 149; epinephrine, 97 +/- 38% of basal insulin, mean +/- SE, n = 6, P &lt; 0.02); SS markedly augmented the AIR during epinephrine towards control values (339 +/- 137%; P &lt; 0.02).	Epinephrine	18-29	insulin	Homo sapiens	51-58
6255805-4	1980	The lower dose of epinephrine diminished the acute insulin response (AIR) after a 20-g intravenous glucose pulse (control, 463 +/- 149; epinephrine, 97 +/- 38% of basal insulin, mean +/- SE, n = 6, P &lt; 0.02); SS markedly augmented the AIR during epinephrine towards control values (339 +/- 137%; P &lt; 0.02).	Epinephrine	18-29	insulin	Homo sapiens	169-176
6108152-6	1980	However, replacement with epinephrine (4 mg/kg, daily) completely prevented the fall of TH activity in adrenalectomized animals.	Epinephrine	26-37	tyrosine hydroxylase	Mus musculus	88-90
6108152-7	1980	Isoproterenol, a beta-adrenergic receptor agonist, was as effective as epinephrine in preventing the reduction of TH activity following adrenalectomy.	Epinephrine	71-82	tyrosine hydroxylase	Mus musculus	114-116
6108152-8	1980	Furthermore, in intact animals, chronic administration of SKF 64139, an inhibitor of adrenal PNMT which depletes circulating epinephrine levels, also reduced ganglionic TH activity to the same level as that after adrenalectomy.	Epinephrine	125-136	phenylethanolamine-N-methyltransferase	Mus musculus	93-97
6108152-9	1980	These results indicate that epinephrine, but not corticosterone, is the adrenal factor required for physiological maintenance of normal levels of TH in the superior cervical ganglion.	Epinephrine	28-39	tyrosine hydroxylase	Mus musculus	146-148
6110570-8	1980	In conclusion, somatostatin counteracts the decrease of platelet aggregation response to ADP seen in saline studies, induces the appearance of platelet aggregates in diabetics and potentiates the aggregation response to epinephrine (in vitro) in both normals and diabetics.	Epinephrine	220-231	somatostatin	Homo sapiens	15-27
6253495-8	1980	The number of molecules bound per cell was stimulus-dependent, with 30 microM epinephrine inducing the binding of fewer fibrinogen molecules per cell (mean = 20,400) than 10 microM ADP (mean = 35,900) or the combination of 5 microM epinephrine + 0.5 microM ADP (mean = 43,600).	Epinephrine	78-89	fibrinogen beta chain	Homo sapiens	120-130
7002951-1	1980	The epinephrine response to insulin-induced hypoglycemia has been studied in patients with orthostatic hypotension and in control subjects.	Epinephrine	4-15	insulin	Homo sapiens	28-35
6253495-0	1980	Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP.	Epinephrine	59-70	fibrinogen beta chain	Homo sapiens	17-27
7202481-1	1980	After 7 day dosing with SK &amp; F 64139, an inhibitor of adrenal and CNS PNMT, a stoichiometric relationship is observed between epinephrine decrease and norepinephrine increase in adrenal tissue.	Epinephrine	130-141	phenylethanolamine-N-methyltransferase	Rattus norvegicus	74-78
6253495-8	1980	The number of molecules bound per cell was stimulus-dependent, with 30 microM epinephrine inducing the binding of fewer fibrinogen molecules per cell (mean = 20,400) than 10 microM ADP (mean = 35,900) or the combination of 5 microM epinephrine + 0.5 microM ADP (mean = 43,600).	Epinephrine	232-243	fibrinogen beta chain	Homo sapiens	120-130
6253495-0	1980	Induction of the fibrinogen receptor on human platelets by epinephrine and the combination of epinephrine and ADP.	Epinephrine	94-105	fibrinogen beta chain	Homo sapiens	17-27
6253495-1	1980	The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP.	Epinephrine	16-27	fibrinogen beta chain	Homo sapiens	112-122
6253495-9	1980	The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet.	Epinephrine	61-72	fibrinogen beta chain	Homo sapiens	39-49
6253495-1	1980	The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP.	Epinephrine	66-77	fibrinogen beta chain	Homo sapiens	112-122
6253495-1	1980	The capacity of epinephrine alone and the combination of low dose epinephrine and ADP to support the binding of fibrinogen to washed human platelets has been examined, 125I-Fibrinogen was bound to epinephrine-stimulated platelets, but 90 min were required to achieve maximal binding at 22 degrees C in contrast to 20 to 30 min with ADP.	Epinephrine	66-77	fibrinogen beta chain	Homo sapiens	112-122
6253495-2	1980	The overall rate of interaction appeared to reflect the slow binding of fibrinogen to epinephrine-stimulated platelets as opposed to the rate of stimulation of the cell.	Epinephrine	86-97	fibrinogen beta chain	Homo sapiens	72-82
6253495-4	1980	Fibrinogen binding was maximally supported by 20 to 30 microM epinephrine.	Epinephrine	62-73	fibrinogen beta chain	Homo sapiens	0-10
6253495-5	1980	The combination of low dose epinephrine (5 microM) and low dose ADP (0.5 microM), which acted synergistically to induce platelet aggregation, supported the rapid (10 min) binding of fibrinogen to platelets.	Epinephrine	28-39	fibrinogen beta chain	Homo sapiens	182-192
6253495-6	1980	With 4 microM epinephrine, more fibrinogen bound per platelet at all ADP doses than with ADP alone.	Epinephrine	14-25	fibrinogen beta chain	Homo sapiens	32-42
6253495-9	1980	The participation of endogenous ADP in fibrinogen binding to epinephrine-stimulated platelets was suggested since enzymes which remove ADP, apyrase, and creatine phosphate/creatine phosphokinase, and the ADP analogue, 2-chloroadenosine, completely inhibited the binding of fibrinogen to the platelet.	Epinephrine	61-72	fibrinogen beta chain	Homo sapiens	273-283
7000585-6	1980	Similarly, infusion of epinephrine in the insulin-infused diabetics produced a 23% fall in total amino acids, a 37% decline in branched chain amino acids, but no change in plasma alanine.	Epinephrine	23-34	insulin	Homo sapiens	42-49
7004910-2	1980	Strophanthin K interferes with the renin-secreting action of adrenaline and perverts its activating effect on sodium transport by renal tubules.	Epinephrine	61-71	renin	Rattus norvegicus	35-40
7000585-8	1980	In addition, when epinephrine was infused into two insulin-withdrawn diabetics, a comparable hypoaminoacidemic response was observed.	Epinephrine	18-29	insulin	Homo sapiens	51-58
7007198-1	1980	Insulin and adenosine are both antilipolytic when studied in the epinephrine-stimulated perifused isolated fat cell.	Epinephrine	65-76	insulin	Homo sapiens	0-7
7000585-10	1980	It is concluded that (1) increments in epinephrine similar to those observed in stress cause a decline in circulating amino acids (except alanine) which is greatest for the branched chain amino acids; (2) this hypoaminoacidemic effect occurs in the absence of a rise in plasma insulin and diabetic subjects, as well; and (3) epinephrine-induced changes in amino acid regulation are prevented by beta-adrenergic blockade.	Epinephrine	39-50	insulin	Homo sapiens	277-284
7007198-3	1980	The polypeptide hormone insulin produces an antilipolytic effect which manifests itself as a "lag" in restoration of epinephrine-stimulated lipolysis after removal of the insulin.	Epinephrine	117-128	insulin	Homo sapiens	24-31
7001182-3	1980	When alpha adrenergic blockade was superimposed on beta blockade, the increase in glucose production and the decrease in both plasma insulin and glucose clearance observed during infusion of epinephrine alone was virtually abolished.	Epinephrine	191-202	insulin	Homo sapiens	133-140
6775681-8	1980	Addition of 0.1 microM epinephrine to the 125I-factor VIII/vWF labelled endothelial cultures induced the release of cell bound, protein-associated radioactivity into the medium.	Epinephrine	23-34	von Willebrand factor	Homo sapiens	59-62
7001179-5	1980	In the postoperative period, however, suppressed insulin secretion was found to be correlated with elevated plasma epinephrine concentrations and may, therefore, be mediated by adrenergic mechanisms.	Epinephrine	115-126	insulin	Homo sapiens	49-56
7001181-3	1980	The latter results from epinephrine-induced suppression of endogenous insulin secretion and, more importantly from a direct inhibitory effect on insulin-stimulated glucose utilization.	Epinephrine	24-35	insulin	Homo sapiens	70-77
6161382-4	1980	The antilipolytic effect of insulin on adrenaline and 1-methyl-3-isobutyl xanthine stimulated lipolysis, is suppressed in the presence of inhibitors of prostaglandin synthetase i.e. indomethacin or phenelzine.	Epinephrine	39-49	insulin	Homo sapiens	28-35
7001974-7	1980	Our data suggest marked sensitivity to the insulin antagonistic effects of epinephrine and may provide a mechanism for stress-induced glucose intolerance.	Epinephrine	75-86	insulin	Homo sapiens	43-50
6168549-4	1980	Theophylline, epinephrine and isoproterenol increased the cyclic AMP level and strongly inhibited edema formation and histamine release, in all animals.	Epinephrine	14-25	transmembrane serine protease 5	Rattus norvegicus	65-68
6779301-4	1980	Epinephrine was assessed for its effects on the lag phase in activation of soybean lipoxygenase and was found to cause a similar reduction of the lag phase of this related enzyme.	Epinephrine	0-11	linoleate 9S-lipoxygenase-4	Glycine max	83-95
7052550-2	1980	All PNMT inhibitors tested were effective in depleting hypothalamic and brain stem epinephrine.	Epinephrine	83-94	phenylethanolamine-N-methyltransferase	Rattus norvegicus	4-8
6775681-12	1980	We conclude that factor VIII/vWF binds to endothelial cells and that this cell-bound protein is mobilized by epinephrine through beta-adrenergic stimulation.	Epinephrine	109-120	von Willebrand factor	Homo sapiens	29-32
6257880-5	1980	When KK mice had been injected with IAP, they responded to epinephrine and isoproterenol more readily than did ddY mice in increasing plasma insulin and glycerol.	Epinephrine	59-70	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	36-39
6997131-7	1980	Adrenergic beta-receptor stimulation with epinephrine plus phentolamine caused a sevenfold rise from 45 +/- 10 to 351 +/- 60 pM (P &lt; 0.05), whereas adrenergic alpha-receptor stimulation caused a significant fall from 100 +/- 25 pM (the rise in hPP concentration induced by epinephrine) to 44 +/- 7.8 pM.	Epinephrine	42-53	familial progressive hyperpigmentation 1	Homo sapiens	247-250
7000956-0	1980	Effects of adrenaline and amino acids on the release of insulin in the sheep fetus.	Epinephrine	11-21	LOC105613195	Ovis aries	56-63
7000956-3	1980	The adrenaline infusion also caused hyperglycaemia and a reduction in the basal plasma insulin concentration in the fetus in the period before the infusion of glucose or arginine was given.	Epinephrine	4-14	LOC105613195	Ovis aries	87-94
7007619-9	1980	Adrenaline completely abolished the insulin response to glucose in the warm environment.	Epinephrine	0-10	LOC105613195	Ovis aries	36-43
6997131-10	1980	The rise induced by adrenergic beta-receptor stimulation with epinephrine plus phentolamine was equivalent to the rise from 40 +/- 11 to 280 +/- 48 pM caused by an insulin-induced fall in serum glucose of about 50% and that induced by isoproterenol infusion, which caused a fourfold rise from 69 +/- 3 to 271 +/- 84 pM.	Epinephrine	62-73	insulin	Homo sapiens	164-171
6105069-3	1980	Bombesin, carbachol, or 2-deoxyglucose, injected icv, evoked marked elevations in plasma epinephrine and norepineprine.	Epinephrine	89-100	gastrin releasing peptide	Homo sapiens	0-8
6248606-4	1980	The agonist pattern of adenylate cyclase activation suggested the presence of beta-2 adrenergic receptors, since isoproterenol with a Kact of 0.7 microM was more potent than epinephrine (Kact = 8.5 microM) or norepinephrine (Kact = 90 microM).	Epinephrine	174-185	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	78-84
6251499-6	1980	Epinephrine reverses the refractory state and potentiates the response of dissociated cells to the action of thrombin, arachidonate and ionophore A23187.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	109-117
6105122-1	1980	In vitro incubation studies with bovine parathyroid gland slices compared the relative responsiveness of parathyroid hormone (PTH) secretion to isoprotherenol, epinephrine or norepinephrine.	Epinephrine	160-171	parathyroid hormone	Bos taurus	105-124
6995479-5	1980	At steady-state plasma epinephrine concentrations of 24-74 pg/ml, values overlapping the basal normal range, the mean (+/-SE) plasma metabolic clearance rate of epinephrine was 52 +/- 4 ml x min-1 x kg-1; this value rose to 89 +/- 6 ml x min-1 x kg-1 (P less than 0.01) at steady-state epinephrine concentrations of 90-1,020 pg/ml.	Epinephrine	161-172	CD59 molecule (CD59 blood group)	Homo sapiens	191-196
6995479-5	1980	At steady-state plasma epinephrine concentrations of 24-74 pg/ml, values overlapping the basal normal range, the mean (+/-SE) plasma metabolic clearance rate of epinephrine was 52 +/- 4 ml x min-1 x kg-1; this value rose to 89 +/- 6 ml x min-1 x kg-1 (P less than 0.01) at steady-state epinephrine concentrations of 90-1,020 pg/ml.	Epinephrine	161-172	CD59 molecule (CD59 blood group)	Homo sapiens	191-196
7000971-2	1980	The assay consists basically of 1. conversion of epinephrine, norepinephrine, and dopamine into their respective methyl-derivates in the presence of catechol-O-methyltransferase and S-adenosylmethionine-[3H]methyl, 2. extraction of the methylated 3H labelled amines with diethyl ether, 3. separation by thin-layer chromatography, 4. measurement in a beta radiation scintillation counter.	Epinephrine	49-60	catechol-O-methyltransferase	Homo sapiens	149-177
7403340-2	1980	Concentrations of ADP, thrombin and arachidonate that caused reversible stimulation of aspirin platelets produced irreversible aggregation when the aspirin samples had been pretreated with epinephrine.	Epinephrine	189-200	coagulation factor II, thrombin	Homo sapiens	23-31
6257217-4	1980	When adrenaline of alpha-phenylephrine was administered, the CGT cells degranulated, and there was a concomitant loss of intracellular EGF-positive immunofluorescence.	Epinephrine	5-15	epidermal growth factor	Mus musculus	135-138
6769714-2	1980	Dopamine may be a physiological prolactin inhibiting factor (PIF), while norepinephrine and possibly epinephrine regulate prolactin release at the level of the hypothalamus.	Epinephrine	76-87	prolactin	Homo sapiens	122-131
7358496-1	1980	A double-blind, randomized, placebo-control study of the effect of epinephrine on the rate of aqueous formation in eyes pretreated with a beta-adenergic blocking drug was carried out in 25 normal subjects with the use of fluorophotometry.	Epinephrine	67-78	amyloid beta precursor protein	Homo sapiens	136-142
6990786-5	1980	Plasma insulin decreased during alpha-adrenergic stimulation but increased during infusion of epinephrine alone.	Epinephrine	94-105	insulin	Homo sapiens	7-14
6251492-9	1980	However, epinephrine addition to refractory platelets restored in large measure their sensitivity to aggregation by arachidonate, thrombin, ADP and A23187.	Epinephrine	9-20	coagulation factor II, thrombin	Homo sapiens	130-138
6987265-6	1980	Second, epinephrine blocked the effect of high glucose on both insulin release and potentiation of CCK action.	Epinephrine	8-19	cholecystokinin	Rattus norvegicus	99-102
6247420-9	1980	The inotropic effect of epinephrine is inhibited to a large extent by cGMP but not by GMP-PNP.	Epinephrine	24-35	5'-nucleotidase, cytosolic II	Homo sapiens	71-74
6994715-12	1980	The precocious induction of glucokinase by glucose is inhibited by simultaneous treatment with approriate amounts of adrenaline, glucagon, dibutyryl cyclic AMP or isoprenaline but not by vasopressin or angiotensin II.	Epinephrine	117-127	glucokinase	Rattus norvegicus	28-39
7363628-11	1980	Epinephrine improved blood flow to the heart during CPR much more than the other agents, probably because of its combined alpha- and beta-adrenergic activity.	Epinephrine	0-11	cytochrome p450 oxidoreductase	Canis lupus familiaris	52-55
6101988-3	1980	However, in the C-2-area, the epinephrine and norepinephrine stimulated cyclic AMP formation involved the activation of a single receptor type which was alpha-like in character.	Epinephrine	30-41	complement C2	Rattus norvegicus	16-19
6101988-4	1980	Stimulation of cyclic AMP formation by epinephrine in the C-2 area was antagonized by nanomolar concentrations of both phentolamine and yohimbine.	Epinephrine	39-50	complement C2	Rattus norvegicus	58-61
6101988-5	1980	The epinephrine-stimulated formation of cyclic AMP in the C-2 but not in the C-1 area was augmented in a strains of rats which exhibit spontaneous genetic hypertension (SHR) vs. Wistar-Kyoto controls.	Epinephrine	4-15	complement C2	Rattus norvegicus	58-61
6101988-6	1980	It is suggested that the enhanced epinephrine-stimulated cyclic AMP formation in the C-2 area of SHR rats could be a physiological compensatory response to some other hypertension-causing lesion which, for example, results in chronically reduced epinephrine release or in ruduced availability of epinephrine at its postsynaptic receptor thereby leading to receptor supersensitivity.	Epinephrine	34-45	complement C2	Rattus norvegicus	85-88
6101988-6	1980	It is suggested that the enhanced epinephrine-stimulated cyclic AMP formation in the C-2 area of SHR rats could be a physiological compensatory response to some other hypertension-causing lesion which, for example, results in chronically reduced epinephrine release or in ruduced availability of epinephrine at its postsynaptic receptor thereby leading to receptor supersensitivity.	Epinephrine	246-257	complement C2	Rattus norvegicus	85-88
6101988-6	1980	It is suggested that the enhanced epinephrine-stimulated cyclic AMP formation in the C-2 area of SHR rats could be a physiological compensatory response to some other hypertension-causing lesion which, for example, results in chronically reduced epinephrine release or in ruduced availability of epinephrine at its postsynaptic receptor thereby leading to receptor supersensitivity.	Epinephrine	246-257	complement C2	Rattus norvegicus	85-88
6101988-7	1980	Supporting this possibility was the finding that treatment of SHRs and control animals and reserpine resulted in enhancement of epinephrine-stimulated cyclic AMP formation in the C-2 area of control rats, essentially obliterating the difference between control and SHR.	Epinephrine	128-139	complement C2	Rattus norvegicus	179-182
7052338-1	1980	1 The effects of adrenoceptor blocking drugs on the metabolic responses to adrenaline infusion (1 microgram kg-1 min-1) have been studied in the anaesthetized, fasted cat.	Epinephrine	75-85	CD59 molecule (CD59 blood group)	Homo sapiens	113-118
7052338-3	1980	3 Phentolamine infusion, at a rate (15 micrograms kg-1 min-1 after a priming dose of 2.5 mg/kg) which reversed the pressor effect of adrenaline, reduced but did not abolish adrenaline-induced hyperglycaemia.	Epinephrine	133-143	CD59 molecule (CD59 blood group)	Homo sapiens	55-60
6243677-0	1980	Epinephrine-induced insulin resistance in man.	Epinephrine	0-11	insulin	Homo sapiens	20-27
6243677-9	1980	When epinephrine was infused with insulin, glucose metabolism fell by 41% to 3.26 mg/kg.min (P &lt; 0.001).	Epinephrine	5-16	insulin	Homo sapiens	34-41
6243677-14	1980	These results indicate that epinephrine, acting primarily through a beta-adrenergic receptor, markedly impairs tissue sensitivity to an increase in plasma insulin levels, and that this effect results from both peripheral and hepatic resistance to the action of insulin.	Epinephrine	28-39	insulin	Homo sapiens	155-162
6244010-0	1980	Partial inhibition by lithium of the epinephrine-stimulated rise in plasma cyclic GMP in humans.	Epinephrine	37-48	5'-nucleotidase, cytosolic II	Homo sapiens	82-85
6243677-14	1980	These results indicate that epinephrine, acting primarily through a beta-adrenergic receptor, markedly impairs tissue sensitivity to an increase in plasma insulin levels, and that this effect results from both peripheral and hepatic resistance to the action of insulin.	Epinephrine	28-39	insulin	Homo sapiens	261-268
6153717-4	1980	In fact, at some doses PA and NAPA accentuated the pressor and positive chronotropic effects of epinephrine.	Epinephrine	96-107	NSF attachment protein alpha	Canis lupus familiaris	30-34
6244010-2	1980	The rise in plasma cyclic GMP in response to epinephrine was found to be partially inhibited by lithium treatment, and previous reports of lithium inhibition of the plasma cyclic AMP rise were replicated.	Epinephrine	45-56	5'-nucleotidase, cytosolic II	Homo sapiens	26-29
6768091-3	1980	In men, a strong and transient discharge of epinephrine (E) is observed in plasma, corresponding to a great increase in the urinary level of this amine in the 2 h period following insulin.	Epinephrine	44-55	insulin	Homo sapiens	180-187
6102386-1	1980	Ornithine decarboxylase (ODCase; L-ornithine carboxy-lyase; EC 4.1.1.17) activity was increased 5-20 fold above basal activity by N(6),O(2")-dibutyryl cyclic AMP, isoproterenol, epinephrine, or fetal calf serum in confluent C6-2B rat astrocytoma cells.	Epinephrine	178-189	ornithine decarboxylase, structural 1	Mus musculus	0-23
6243761-2	1980	Postsynaptic response to epinephrine was defective in chronic EAMG with high titers of antibody, suggesting that active Na-K transport system modulated by cyclic adenosine monophosphate (AMP) may be affected primarily by antibody.	Epinephrine	25-36	TANK binding kinase 1	Homo sapiens	120-124
6102386-1	1980	Ornithine decarboxylase (ODCase; L-ornithine carboxy-lyase; EC 4.1.1.17) activity was increased 5-20 fold above basal activity by N(6),O(2")-dibutyryl cyclic AMP, isoproterenol, epinephrine, or fetal calf serum in confluent C6-2B rat astrocytoma cells.	Epinephrine	178-189	ornithine decarboxylase, structural 1	Mus musculus	25-31
7352016-7	1980	The reversal potential for substance P is shown to be identical to that obtained in the same cells for acetylcholine (ACh) and adrenaline.	Epinephrine	127-137	tachykinin precursor 1	Homo sapiens	27-38
7350241-6	1980	When the second wave of gamma-thrombin- or epinephrine-induced aggregation was inhibited by very high levels of CP/CPK, the inhibition was overcome by an increase in the level of stimulus.	Epinephrine	43-54	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	112-118
6153144-3	1980	Application of preferential beta-1 and beta-2-receptor antagonists and agonists localized the epinephrine effect to beta-2-adrenergic mediation.	Epinephrine	94-105	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	116-122
7399354-1	1980	Release of platelet antiheparin activity (platelet factor 4, PF4) induced by collagen and l-epinephrine, is normal in newborn infants without antenatal drug exposure.	Epinephrine	90-103	platelet factor 4	Homo sapiens	61-64
6153144-1	1980	Epinephrine, norepinephrine, and isoproterenol produced dose-dependent stimulation of ornithine decarboxylase (EC 4.1.1.17) activity in isolated porcine granulosa cells maintained under defined conditions in vitro.	Epinephrine	0-11	ornithine decarboxylase 1	Homo sapiens	86-109
6153144-3	1980	Application of preferential beta-1 and beta-2-receptor antagonists and agonists localized the epinephrine effect to beta-2-adrenergic mediation.	Epinephrine	94-105	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	28-34
6153144-3	1980	Application of preferential beta-1 and beta-2-receptor antagonists and agonists localized the epinephrine effect to beta-2-adrenergic mediation.	Epinephrine	94-105	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-45
7446007-1	1980	The oxytocinase activity in the blood serum, umbilical blood and homogenates from the placenta and umbilical cord was determined in 34 women in labor subjected to continuous lumbar epidural analgesia with 0.125 per cent bupivacaine and 1:800 000 epinephrine.	Epinephrine	246-257	leucyl and cystinyl aminopeptidase	Homo sapiens	4-15
7431437-1	1980	The changes of phenylethanolamine-N-methyltransferase (PNMT, EC 2.1.1.28), the enzyme that catalyzes the final step in the biosynthesis of adrenaline, were studied during the development of several regions of rat brain.	Epinephrine	139-149	phenylethanolamine-N-methyltransferase	Rattus norvegicus	15-53
7431437-1	1980	The changes of phenylethanolamine-N-methyltransferase (PNMT, EC 2.1.1.28), the enzyme that catalyzes the final step in the biosynthesis of adrenaline, were studied during the development of several regions of rat brain.	Epinephrine	139-149	phenylethanolamine-N-methyltransferase	Rattus norvegicus	55-59
7441798-5	1980	In cerebellum and medulla oblongata-pons, the adrenaline content reaches a maximum at 15 days which is close to the time in which the levels of phenylethanolamine-N-methyltransferase (PNMT) reach their maximum.	Epinephrine	46-56	phenylethanolamine-N-methyltransferase	Rattus norvegicus	184-188
7351877-3	1980	Insulin suppression was obtained by means of a constant infusion of epinephrine (6 microgram/min) and propranolol (0.08 mg/min).	Epinephrine	68-79	insulin	Homo sapiens	0-7
7441798-6	1980	In midbrain and hypothalamus, there is a lag between the adult levels of adrenaline and the activity of PNMT.	Epinephrine	73-83	phenylethanolamine-N-methyltransferase	Rattus norvegicus	104-108
44425-3	1979	Intravenous infusion of noradrenaline or adrenaline markedly reduced rCBF (by 22-48% of control levels) in all regions except thalamus, mesencephalon, and pons.	Epinephrine	27-37	CCAAT/enhancer binding protein zeta	Rattus norvegicus	69-73
531079-4	1979	These results indicate that pigeon brain NMT is similar to that in mammalian brain and adrenal glands and can be inhibited by agents previously used to deplete brain epinephrine selectively in rats.	Epinephrine	166-177	N-myristoyltransferase 1	Homo sapiens	41-44
546341-0	1979	[NMR determination of the conformation of adrenaline in a complex with Mg2+ and ATP].	Epinephrine	42-52	mucin 7, secreted	Homo sapiens	71-74
393296-8	1979	PRP obtained from normal subjects after the ingestion of aspirin exhibited only one wave of aggregation in response to ADP, adrenaline or collagen, PGI2, PGD2 and PGE1 were all powerful inhibitors of this single wave of aggregation.	Epinephrine	124-134	prion protein	Homo sapiens	0-3
517645-0	1979	Insulin antagonistic effects of epinephrine and glucagon in the dog.	Epinephrine	32-43	insulin	Canis lupus familiaris	0-7
517645-1	1979	The effect of glucagon and/or epinephrine on the response to physiologic insulin infusion was evaluated in dogs.	Epinephrine	30-41	insulin	Canis lupus familiaris	73-80
517645-4	1979	Epinephrine infusion blocked the fall in glucose output as well as the insulin-induced rise in glucose clearance and uptake.	Epinephrine	0-11	insulin	Canis lupus familiaris	71-78
517645-5	1979	Thus, while epinephrine and glucagon were equally effective in preventing the fall in glucose output induced by insulin, epinephrine was more effective in preventing insulin-induced hypoglycemia by virtue of its direct inhibitory action on insulin-stimulated glucose utilization.	Epinephrine	121-132	insulin	Canis lupus familiaris	166-173
517645-5	1979	Thus, while epinephrine and glucagon were equally effective in preventing the fall in glucose output induced by insulin, epinephrine was more effective in preventing insulin-induced hypoglycemia by virtue of its direct inhibitory action on insulin-stimulated glucose utilization.	Epinephrine	121-132	insulin	Canis lupus familiaris	166-173
232027-13	1979	If adrenaline infusion can be considered as a model for acute stress, our results seem to favour a selective beta 1-adrenoreceptor blocking agent over a non-selective one, even when the blocker is combined with a diuretic or a vasodilator.	Epinephrine	3-13	adrenoceptor beta 1	Homo sapiens	109-130
43302-5	1979	PNMT was found not only in the ground substance but also on the membrane of some adrenaline-containing granules.	Epinephrine	81-91	phenylethanolamine-N-methyltransferase	Rattus norvegicus	0-4
574143-8	1979	Thus, these studies demonstrate that platelet stimulation by ADP and epinephrine exposes a limited number of fibrinogen receptors on the platelet surface.	Epinephrine	69-80	fibrinogen beta chain	Homo sapiens	109-119
551286-6	1979	In view of these observations, a report that unphysiologically large (5--15 mg ml(-1)) amounts of AAG inhibit the platelet aggregation induced by ADP and adrenaline, and evidence that a sialic acid-deficient species of AAG appears elevated in several chronic disease states, we compared the effects of AAG and its desialised counterpart (AAG-D) on platelet aggregation.	Epinephrine	154-164	N-methylpurine DNA glycosylase	Homo sapiens	98-101
41729-3	1979	Concentrations of noradrenaline, adrenaline and methoxamine of 10(-6), 10(-5), 10(-4) and 10(-3) M caused significant dose-related inhibition of renin release.	Epinephrine	21-31	renin	Rattus norvegicus	145-150
226892-1	1979	Both beta 2-adrenoreceptor stimulants (such as adrenaline and salbutamol) and insulin can increase active Na+-K+ transport and hyperpolarise skeletal cells.	Epinephrine	47-57	adrenoceptor beta 2	Rattus norvegicus	5-26
444585-6	1979	Incubation of the cells in the (Ca2+ + Mg2+)-free medium reduced but did not abolish the ability of adrenaline to stimulate lipolysis or the ability of insulin to inhibit the adrenaline-stimulated lipolysis.	Epinephrine	175-185	insulin	Homo sapiens	152-159
43064-2	1979	The leakage of 125IHSA (human serum albumin) into the brains from rats given adrenaline was significantly larger than in the brains from rats given noradrenaline or angiotensin.	Epinephrine	77-87	albumin	Rattus norvegicus	30-43
485920-7	1979	These results fit the theory that the esterase converting dipivefrin to epinephrine is inactivated by cholinesterase inhibitors.	Epinephrine	72-83	cholinesterase	Oryctolagus cuniculus	102-116
487592-2	1979	Noradrenaline and adrenaline are converted to their O-methylated analogues, normethanephrine and metanephrine, by the enzyme catechol O-methyltransferase in the presence of tritiated S-adenosyl-L-methionine.	Epinephrine	3-13	catechol-O-methyltransferase	Homo sapiens	125-153
443450-1	1979	Previous work from our laboratory has shown that physiological increments of circulating epinephrine concentration increase plasma renin activity (PRA) by an extrarenal beta-receptor mechanism.	Epinephrine	89-100	renin	Canis lupus familiaris	131-136
495714-2	1979	Epinephrine increased glucose production and plasma glucagon transiently but caused persistent suppression of glucose clearance and sustained hyperglycemia (despite increased plasma insulin and gluconeogenic substrates); glucose production increased again on addition of glucagon and on increasing the epinephrine infusion rate.	Epinephrine	0-11	insulin	Homo sapiens	182-189
495714-4	1979	In conclusion, 1) in man hyperepinephrinemia within the physiological range caused sustained suppression of glucose clearance but only a transient increase in glucose production; 2) this transient hepatic response a) was not due to glycogen or substrate depletion, b) occurred without changes in plasma glucagon or insulin, c) was specific for epinephrine but permitted subsequent responses to changes in plasma epinephrine; 3) epinephrine can serve as a physiological regulator of glucose homeostasis in man both by increasing glucose production and by decreasing glucose clearance.	Epinephrine	30-41	insulin	Homo sapiens	315-322
467325-4	1979	Administration of bombesin into the lateral ventricle of awake, unrestrained animals results in elevation of plasma glucose, preceded by a significant increase in plasma epinephrine and no increase in plasma norepinephrine or dopamine.	Epinephrine	170-181	gastrin releasing peptide	Homo sapiens	18-26
446911-2	1979	Addition of epinephrine or glucagon to the insulin infusion prevented the fall in glucose production throughout the experiment but only partially diminished the hypoglycemic response.	Epinephrine	12-23	insulin	Canis lupus familiaris	43-50
508416-2	1979	On the other hand, UDPG levels--which are similar in the two muscles--are significantly decreased after adrenaline.	Epinephrine	104-114	UDP-glucose pyrophosphorylase 2	Homo sapiens	19-23
225171-1	1979	Phosphorylation of protein phosphatase inhibitor-1 in vivo in response to adrenaline.	Epinephrine	74-84	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	19-50
504691-4	1979	During stimulation of lipolysis by infusions of epinephrine, apparent KH2-PGE2 levels rose five-fold.	Epinephrine	48-59	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	70-78
514953-4	1979	In a second experiment both insulin and epinephrine added in vitro signifiacntly increased activity of lipoprotein lipase from chicken adipose tissue, but not from turkey adipose tissue.	Epinephrine	40-51	lipoprotein lipase	Gallus gallus	103-121
38334-9	1979	Acetylcholine-induced increases in hypothalamic CRH production were reduced by GABA, noradrenaline, adrenaline, methoxamine and phenylephrine but not by isoprenaline.	Epinephrine	88-98	corticotropin releasing hormone	Rattus norvegicus	48-51
427591-2	1979	Some of these areas also showed increased PNMT activity, indicating a possible enhanced release or metabolism of adrenaline early in the development of the hypertension.	Epinephrine	113-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	42-46
219180-2	1979	The effect of glucocorticoids on the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), was examined.	Epinephrine	37-48	phenylethanolamine N-methyltransferase	Bos taurus	70-108
108087-0	1979	Effect of epinephrine on parathyroid hormone secretion in calves.	Epinephrine	10-21	parathyroid hormone	Bos taurus	25-44
219180-2	1979	The effect of glucocorticoids on the epinephrine-synthesizing enzyme, phenylethanolamine N-methyltransferase (PNMT), was examined.	Epinephrine	37-48	phenylethanolamine N-methyltransferase	Bos taurus	110-114
426082-3	1979	Elevation of epinephrine concentration to over 2,000 pg/ml by IVC infusion resulted in a sustained 3.5-fold increase in plasma renin activity (PRA), with only a transient decrease in arterial blood pressure.	Epinephrine	13-24	renin	Canis lupus familiaris	127-132
33189-6	1979	Propranolol, a beta-adrenergic blocking agent which inhibits epinephrine action, blocks both the epinephrine-stimulated phosphorylation and the inactivation of the carboxylase.	Epinephrine	61-72	amyloid beta precursor protein	Rattus norvegicus	13-19
33189-6	1979	Propranolol, a beta-adrenergic blocking agent which inhibits epinephrine action, blocks both the epinephrine-stimulated phosphorylation and the inactivation of the carboxylase.	Epinephrine	97-108	amyloid beta precursor protein	Rattus norvegicus	13-19
420283-6	1979	When somatostatin, insulin, and glucagon were added to epinephrine, the rise in glucose production was reduced in 65% despite replacement of glucagon levels and presumably mild portal insulin deficiency.	Epinephrine	55-66	somatostatin	Canis lupus familiaris	5-17
420283-0	1979	Influence of somatostatin on glucagon- and epinephrine-stimulated hepatic glucose output in the dog.	Epinephrine	43-54	somatostatin	Canis lupus familiaris	13-25
420283-7	1979	These findings suggest that somatostatin: 1) potentiates the stimulatory effect of physiologic hyperglucagonemia on glucose production independent of insulin availability and 2) blunts the stimulatory effect of physiologic increments of epinephrine independent of glucagon availability.	Epinephrine	237-248	somatostatin	Canis lupus familiaris	28-40
546488-1	1979	Catechol O-methyltransferase (COMT) obtained from human liver (HL) and human placenta (HP) was found to be much less active than rat liver (RL) COMT when norepinephrine, epinephrine, dopamine, and isoproterenol are used as substrates.	Epinephrine	157-168	catechol-O-methyltransferase	Homo sapiens	0-28
546488-1	1979	Catechol O-methyltransferase (COMT) obtained from human liver (HL) and human placenta (HP) was found to be much less active than rat liver (RL) COMT when norepinephrine, epinephrine, dopamine, and isoproterenol are used as substrates.	Epinephrine	157-168	catechol-O-methyltransferase	Homo sapiens	30-34
34627-4	1979	The stimulations of D, A, and B cells were abolished by propranolol.alpha-Adrenergic agonism (10 ng/ml epinephrine) after beta-adrenergic blockade) moderately decreased somatostatin (-37+/-7%) secretion, moderately increased glucagon (91+/-19%), and markedly decreased insulin (-85+/-3%) release.	Epinephrine	103-114	somatostatin	Canis lupus familiaris	169-181
436794-4	1979	The increasable effect of CT on the bile calcium excretion was significantly prevented by epinephrine (10 and 100 microgram/100 g BW).	Epinephrine	90-101	calcitonin-related polypeptide alpha	Rattus norvegicus	26-28
17955642-3	1979	It is concluded that desoxycorticosterone potentiates the effects of adrenaline by inhibiting its inactivation by Catechol-O-methyltransferase.	Epinephrine	69-79	COMT	Bos taurus	114-142
535779-5	1979	The activity of enzyme phenylethanolamine-N-methyltransferase followed a similar pattern of evolution as that of adrenaline during pregnancy and postpartum.	Epinephrine	113-123	phenylethanolamine-N-methyltransferase	Rattus norvegicus	23-61
232842-5	1979	The action of adrenaline was found to depend on the insulin dose given before in cases of insulin-induced hypoglycaemia.	Epinephrine	14-24	insulin	Bos taurus	52-59
365654-0	1979	Effects of calcium, lanthanum, and bicarbonate ion on epinephrine modification of insulin release in vitro.	Epinephrine	54-65	insulin	Homo sapiens	82-89
365654-1	1979	The role of calcium flux in mediating epinephrine modification of insulin release was investigated by using lanthanum, an inhibitor of calcium flux, in the in vitro perifusion system.	Epinephrine	38-49	insulin	Homo sapiens	66-73
365654-3	1979	Epinephrine and lanthanum have additive effects in inhibiting insulin secretion to glucose stimulation.	Epinephrine	0-11	insulin	Homo sapiens	62-69
365654-4	1979	The effect of epinephrine prestimulation on insulin secretion to subsequent glucose challenge varies markedly, depending on the presence or absence of bicarbonate ion: epinephrine priming is reversed in the absence of bicarbonate, and effect possibly related to reduced calcium uptake.	Epinephrine	14-25	insulin	Homo sapiens	44-51
365654-5	1979	In the presence of bicarbonate, lanthanum blocks the priming effect of epinephrine on insulin secretion.	Epinephrine	71-82	insulin	Homo sapiens	86-93
418997-2	1979	Insulin induced hypoglycemia was followed by only minimal increase of urine epinephrine secretion, while all controls showed more than 6 times higher increases.	Epinephrine	76-87	insulin	Homo sapiens	0-7
438400-0	1979	Inhibitory effect of adrenaline on oxytocin release in the ewe during the milk-ejection reflex.	Epinephrine	21-31	oxytocin/neurophysin I prepropeptide	Homo sapiens	35-43
438400-2	1979	It was found that administration of adrenaline either before or after udder washing, decreased the oxytocin concentration and milk yield but increased the yield by hand-stripping.	Epinephrine	36-46	oxytocin/neurophysin I prepropeptide	Homo sapiens	99-107
438400-4	1979	These results and the use of a beta-receptor blocker to inhibit the effect of adrenaline at the myoepithelial cell level indicate that in ewes adrenaline can prevent the release of oxytocin from neurohypophysis.	Epinephrine	78-88	oxytocin/neurophysin I prepropeptide	Homo sapiens	181-189
438400-4	1979	These results and the use of a beta-receptor blocker to inhibit the effect of adrenaline at the myoepithelial cell level indicate that in ewes adrenaline can prevent the release of oxytocin from neurohypophysis.	Epinephrine	143-153	oxytocin/neurophysin I prepropeptide	Homo sapiens	181-189
118391-0	1979	Thyroid-stimulating hormone and prolactin responses to thyrotropin-releasing hormone during infusion of epinephrine and propranolol in man.	Epinephrine	104-115	thyrotropin releasing hormone	Homo sapiens	55-84
217988-5	1978	Adrenaline caused an alpha-mediated increase in blood glucose that is associated with a fall in plasma insulin concentration.	Epinephrine	0-10	LOC105613195	Ovis aries	103-110
82550-4	1978	The hormonal factors which increase intracellular c-AMP are either of neuroendocrine origin (e.g. epinephrin) or inflammatory products (e.g. prostaglandins and histamine).	Epinephrine	98-108	cathelicidin antimicrobial peptide	Homo sapiens	50-55
30775-4	1978	However, the less active enzyme formed by epinephrine treatment of tissues has a sedimentation constant of 30 to 35 S, whereas that of the enzyme from control tissue is 45 S. Incubation of the less active forms of the carboxylase with 10 mM citrate and up to 10 mg/ml of bovine serum albumin activated the enzyme without any change in the sedimentation constant.	Epinephrine	42-53	albumin	Rattus norvegicus	278-291
33344-2	1978	The high Km value for the brain PNMT has been assumed to be responsible for the low methylation ratio between norepinephrine and epinephrine in the CNS.	Epinephrine	113-124	phenylethanolamine-N-methyltransferase	Rattus norvegicus	32-36
714956-0	1978	Effect of long-term administration of epinephrine and propranolol on serum calcium, parathyroid hormone, and calcitonin in the rat.	Epinephrine	38-49	parathyroid hormone	Rattus norvegicus	84-103
720609-0	1978	A decrease in diacylglycerol acyltransferase after treatment of rat adipocytes with adrenaline.	Epinephrine	84-94	diacylglycerol O-acyltransferase 1	Rattus norvegicus	14-44
213797-3	1978	Catalase diminished the absorbance change with epinephrine, but it did not stop the conversion of arachidonate to prostaglandins.	Epinephrine	47-58	catalase	Homo sapiens	0-8
84757-3	1978	Since the mature secretory granules in the Small Granule Chromaffin (SGC) cell were argentaffin and were mainly located along the cell membrane, this cell was clearly distinguishable under the light microscope both from the A (adrenaline) cell whose secretory granules were non-argentaffin and from the NA (noradrenaline) cell whose cytoplasm was rich and was filled with large, strongly argentaffin granules.	Epinephrine	227-237	serglycin	Mus musculus	43-67
84757-3	1978	Since the mature secretory granules in the Small Granule Chromaffin (SGC) cell were argentaffin and were mainly located along the cell membrane, this cell was clearly distinguishable under the light microscope both from the A (adrenaline) cell whose secretory granules were non-argentaffin and from the NA (noradrenaline) cell whose cytoplasm was rich and was filled with large, strongly argentaffin granules.	Epinephrine	227-237	serglycin	Mus musculus	69-72
361531-3	1978	Infusion of somatostatin suppressed epinephrine-induced glucagon release and this was correlated with a 50% reduction in the hyperglycemic response.	Epinephrine	36-47	somatostatin	Oryctolagus cuniculus	12-24
725851-0	1978	Effects of autoprothrombin II-A on epinephrine-induced platelet aggregation of normal- and coumadin-treated dogs.	Epinephrine	35-46	protein C, inactivator of coagulation factors Va and VIIIa	Canis lupus familiaris	11-31
570403-1	1978	The effect of PLP on the adrenaline-induced relaxation of coronary arteries was studied in vitro, after known inhibitor of COMT, Pyrogallol.	Epinephrine	25-35	proteolipid protein 1	Homo sapiens	14-17
570403-4	1978	It is concluded that PLP enhances the response of coronary smooth muscle to adrenaline by inhibiting a enzymatic pathway for the inactivation of catecholamines.	Epinephrine	76-86	proteolipid protein 1	Homo sapiens	21-24
725851-3	1978	For platelet aggregation, suboptimal concentrations of epinephrine were potentiated by addition of purified autoprothrombin II-A.	Epinephrine	55-66	protein C, inactivator of coagulation factors Va and VIIIa	Canis lupus familiaris	108-128
29771-1	1978	In immature cockerels adrenaline administration lowered the levels of plasma growth hormone.	Epinephrine	22-32	growth hormone 1	Homo sapiens	77-91
744091-10	1978	The results obtained are consistent with the view that epinephrine is rapidly assimilated into the cytoplasm of medullary cells and plays an important role in regulating the concentration of PNMT in the adrenal gland.	Epinephrine	55-66	phenylethanolamine N-methyltransferase	Homo sapiens	191-195
744091-0	1978	The effect of epinephrine on phenylethanolamine N-methyltransferase in cultured explants of adrenal medulla.	Epinephrine	14-25	phenylethanolamine N-methyltransferase	Homo sapiens	29-67
744091-3	1978	Addition of epinephrine to the medium led to a diminution in the activity of PNMT, measurable in the dialyzed homogenates of the cultured tissue.	Epinephrine	12-23	phenylethanolamine N-methyltransferase	Homo sapiens	77-81
683787-5	1978	These results are consistent with the hypothesis that biochemically primitive neuroblastomas deficient in dopamine beta-hydroxylase are move virulent than their mature analogues which produce epinephrine, norepinephrine, and their metabolites.	Epinephrine	192-203	dopamine beta-hydroxylase	Homo sapiens	106-131
744091-5	1978	A diminution in the amount of PNMT protein also resulted from incubation of the explants in the presence of epinephrine.	Epinephrine	108-119	phenylethanolamine N-methyltransferase	Homo sapiens	30-34
400718-4	1978	Moreover, we have tested the effects of iv epinephrine and norepinephrine on plasma hPP concentrations.	Epinephrine	43-54	familial progressive hyperpigmentation 1	Homo sapiens	84-87
400718-9	1978	However, 2 h after epinephrine withdrawal, circulating hPP showed a brisk elevation coinciding with the decline of glycemia to subbaseline values.	Epinephrine	19-30	familial progressive hyperpigmentation 1	Homo sapiens	55-58
659964-1	1978	HAL, a congener of clofibrate, has previously been shown to inhibit epinephrine- and ADP-induced platelet aggregation and 14C-serotonin release.	Epinephrine	68-79	histidine ammonia-lyase	Homo sapiens	0-3
659964-5	1978	When epinephrine was used to initiate aggregation of PRP, HAL (0.96 mM) was found to inhibit MDA production over a wide range of epinephrine concentrations (p less than 0.01).	Epinephrine	5-16	prion protein	Homo sapiens	53-56
659964-5	1978	When epinephrine was used to initiate aggregation of PRP, HAL (0.96 mM) was found to inhibit MDA production over a wide range of epinephrine concentrations (p less than 0.01).	Epinephrine	5-16	histidine ammonia-lyase	Homo sapiens	58-61
659964-5	1978	When epinephrine was used to initiate aggregation of PRP, HAL (0.96 mM) was found to inhibit MDA production over a wide range of epinephrine concentrations (p less than 0.01).	Epinephrine	129-140	prion protein	Homo sapiens	53-56
659964-5	1978	When epinephrine was used to initiate aggregation of PRP, HAL (0.96 mM) was found to inhibit MDA production over a wide range of epinephrine concentrations (p less than 0.01).	Epinephrine	129-140	histidine ammonia-lyase	Homo sapiens	58-61
210721-3	1978	Adrenaline secretion during insulin-induced hypoglycaemia was reduced.	Epinephrine	0-10	insulin	Homo sapiens	28-35
669104-1	1978	The release of pancreatic polypeptide (PP) by gut hormones, acetyl choline and adrenaline was investigated in an isolated perfused pancreas preparation.	Epinephrine	79-89	pancreatic polypeptide	Canis lupus familiaris	15-37
208799-5	1978	Epinephrine antagonizes the lipolysis induced by theophyline on the subscutaneous adipocytes, this action is increased by propranolol (a beta-adrenergic blocking agent).	Epinephrine	0-11	amyloid beta precursor protein	Homo sapiens	135-141
669104-1	1978	The release of pancreatic polypeptide (PP) by gut hormones, acetyl choline and adrenaline was investigated in an isolated perfused pancreas preparation.	Epinephrine	79-89	pancreatic polypeptide	Canis lupus familiaris	39-41
351621-7	1978	Suppression of CSF production by treatment with theophylline or epinephrine, enhancers of cyclic AMP/cyclic GMP ratios, lowered the enhancement of TUR by endotoxic LPS.	Epinephrine	64-75	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	15-18
672009-1	1978	The effect of a single insulin injection on the reaction of the coronary vessels to adrenaline, noradrenaline, and acetylcholine was studied in experiments on dogs.	Epinephrine	84-94	insulin	Canis lupus familiaris	23-30
672009-2	1978	Insulin induces a decrease of arterial pressure and of the resistance of the coronary and peripheral vessels reduces the reflex cholinergic and beta-adrenergic reactions of dilatation of the coronary vessels, and promotes alpha-adrenergic reactions in intracoronary administration of adrenaline and noradrenaline.	Epinephrine	284-294	insulin	Canis lupus familiaris	0-7
206158-1	1978	The relationship between cAMP-dependent protein kinase activity and epinephrine-produced activation of phosphorylase and increase in contractility was investigated in the intact working rat heart.	Epinephrine	68-79	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	40-54
580532-7	1978	Adrenaline and noradrenaline reduce significantly the secretion HCS by full term placentas and have no action on HCG secretion.	Epinephrine	0-10	holocarboxylase synthetase	Homo sapiens	64-67
206158-4	1978	The phosphorylase activity ratio and the rate of left ventricular pressure development increased maximally within 15 s and returned to control in 30-60 s. Continuous infusion of epinephrine caused a sustained elevation of the protein kinase.	Epinephrine	178-189	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	226-240
206158-5	1978	Free catalytic protein kinase activity increased proportionately with the dose of epinephrine.	Epinephrine	82-93	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	15-29
96135-1	1978	Modifications of the plasma level of immunoreactive parathyroid hormone (PTH) in cattle were induced by changes of the plasma concentrations of epinephrine, isoproterenol, or calcium.	Epinephrine	144-155	parathyroid hormone	Bos taurus	52-71
206480-0	1978	Epinephrine enhancement of potassium-stimulated immunoreactive insulin secretion.	Epinephrine	0-11	insulin	Canis lupus familiaris	63-70
206480-2	1978	Although epinephrine stimulates insulin release by activation of beta-adrenergic receptors, its dominant effect (mediated by stimulation of alpha-adrenergic receptors) is an inhibition of insulin secretion that is powerful enough to suppress the secretory activity of insulin"s most potent stimulants.	Epinephrine	9-20	insulin	Canis lupus familiaris	32-39
206480-2	1978	Although epinephrine stimulates insulin release by activation of beta-adrenergic receptors, its dominant effect (mediated by stimulation of alpha-adrenergic receptors) is an inhibition of insulin secretion that is powerful enough to suppress the secretory activity of insulin"s most potent stimulants.	Epinephrine	9-20	insulin	Canis lupus familiaris	188-195
206480-2	1978	Although epinephrine stimulates insulin release by activation of beta-adrenergic receptors, its dominant effect (mediated by stimulation of alpha-adrenergic receptors) is an inhibition of insulin secretion that is powerful enough to suppress the secretory activity of insulin"s most potent stimulants.	Epinephrine	9-20	insulin	Canis lupus familiaris	188-195
638883-3	1978	Epinephrine also inhibited prolactin release.	Epinephrine	0-11	prolactin	Homo sapiens	27-36
217617-0	1978	Effect of piperoxane on serum prolactin: possible role of epinephrine-mediated synapses in the inhibition of prolactin secretion.	Epinephrine	58-69	prolactin	Homo sapiens	109-118
205476-3	1978	Insulin resistance was also significantly greater in hypertriglyceridaemic subjects as determined by measuring the steady-state plasma glucose response during a continuous infusion of epinephrine, propranolol, glucose, and exogenous insulin.	Epinephrine	184-195	insulin	Homo sapiens	0-7
634141-3	1978	infusion of epinephrine in dogs produced a significant rise in plasma gastrin concentration.	Epinephrine	12-23	gastrin	Canis lupus familiaris	70-77
640237-0	1978	Quantitative determination of the interaction between epinephrine and various insulin releasers in man.	Epinephrine	54-65	insulin	Homo sapiens	78-85
205871-0	1978	Genetic regulation of galactokinase in Tetrahymena by cyclic AMP glucose, and epinephrine.	Epinephrine	78-89	galactokinase 1	Homo sapiens	22-35
205871-1	1978	We have found evidence that transcription of the galactokinase (ATP:D-galactose 1-phosphotransferase; EC 2.7.1.6) gene is inhibited, in the animal-like protozoan Tetrahymena, by dibutyryl adenosine 3":5"-cyclic monophosphate, glucose, and epinephrine.	Epinephrine	239-250	galactokinase 1	Homo sapiens	49-62
205871-7	1978	Our results suggest that glucose and epinephrine can regulate transcription of the galactokinase gene by modulation of cyclic nucleotide levels.	Epinephrine	37-48	galactokinase 1	Homo sapiens	83-96
25714-4	1978	Adrenaline administration led to the decrease in insulin/glucose ratio, to a significant fall in serum triiodothyronine and in blood pH.	Epinephrine	0-10	insulin	Canis lupus familiaris	49-56
631642-0	1978	Increased sensitivity of gastrin release to adrenaline in duodenal ulcer.	Epinephrine	44-54	gastrin	Homo sapiens	25-32
631642-3	1978	The maximal rise in serum gastrin concentrations was obtained at a dose of 4 microgram/min adrenaline in both groups of subjects, and the increase was significantly higher in duodenal ulcer patients than in controls.	Epinephrine	91-101	gastrin	Homo sapiens	26-33
631642-4	1978	Adrenaline increased predominantly the gastrin III component (gastrin-17 like) in both duodenal ulcer patients and controls.	Epinephrine	0-10	gastrin	Homo sapiens	39-46
631642-4	1978	Adrenaline increased predominantly the gastrin III component (gastrin-17 like) in both duodenal ulcer patients and controls.	Epinephrine	0-10	gastrin	Homo sapiens	62-69
631642-5	1978	The threshold level of adrenaline-induced gastrin release was significantly lower in duodenal ulcer patients: intravenous infusion of adrenaline in a dose of 0.12 microgram and 0.25 microgram/min increased serum gastrin concentrations 23 and 43%, respectively, but had no effect in controls.	Epinephrine	23-33	gastrin	Homo sapiens	42-49
631642-5	1978	The threshold level of adrenaline-induced gastrin release was significantly lower in duodenal ulcer patients: intravenous infusion of adrenaline in a dose of 0.12 microgram and 0.25 microgram/min increased serum gastrin concentrations 23 and 43%, respectively, but had no effect in controls.	Epinephrine	23-33	gastrin	Homo sapiens	212-219
631642-5	1978	The threshold level of adrenaline-induced gastrin release was significantly lower in duodenal ulcer patients: intravenous infusion of adrenaline in a dose of 0.12 microgram and 0.25 microgram/min increased serum gastrin concentrations 23 and 43%, respectively, but had no effect in controls.	Epinephrine	134-144	gastrin	Homo sapiens	42-49
631642-5	1978	The threshold level of adrenaline-induced gastrin release was significantly lower in duodenal ulcer patients: intravenous infusion of adrenaline in a dose of 0.12 microgram and 0.25 microgram/min increased serum gastrin concentrations 23 and 43%, respectively, but had no effect in controls.	Epinephrine	134-144	gastrin	Homo sapiens	212-219
631642-8	1978	The results indicate that endogenous adrenaline may stimulate the secretion of gastrin during physiological conditions in patients with duodenal ulcer.	Epinephrine	37-47	gastrin	Homo sapiens	79-86
666671-1	1978	In acute experiments on the in utero foetal lamb, angiotensin II was a more potent pressor agent that either noradrenaline or adrenaline, and the response to angiotensin II was not consistently modified by the combined administration of alpha and beta-adrenergic blocking agents.	Epinephrine	112-122	angiotensinogen	Homo sapiens	50-64
624369-2	1978	Maximal increments in adrenaline and dexamethasone (DXM) plasma concentrations were observed c15 (T50 40 min) and 30 (T50 210-240 min) minutes after an i.v.	Epinephrine	22-32	placenta associated 8	Homo sapiens	93-96
666671-6	1978	It is concluded that the foetus, like the adult  animal, is more sensitive to angiotensin II than to catecholamines and that the biological activities of noradrenaline, angiotensin II, adrenaline and isoprenaline are reduced by perfusion through the foetal placenta.	Epinephrine	157-167	angiotensinogen	Homo sapiens	78-92
747039-0	1978	Inhibition of adrenaline-potentiated thrombin-induced reaction of human blood platelets by dihydroergotoxine.	Epinephrine	14-24	coagulation factor II, thrombin	Homo sapiens	37-45
621347-6	1978	The major difference related to mechanisms of action was the failure of con A to induce a systemic beta-adrenergic blockade, the block of which is manifested in HSF-treated CFW and CFI mice by the inhibition of an epinephrine-induced hyperglycemia.	Epinephrine	214-225	complement component factor i	Mus musculus	181-184
747039-1	1978	The potentiating effect of adrenaline on thrombin-induced aggregation and release reaction of human blood platelets has been studied in vitro.	Epinephrine	27-37	coagulation factor II, thrombin	Homo sapiens	41-49
202205-7	1978	The authors propose that suppression of insulin secretion during surgery may be caused by adrenaline, which, in competing for the glucose receptors, insensitizes the pancreatic beta-cells.	Epinephrine	90-100	insulin	Homo sapiens	40-47
567191-6	1978	Inhibition of ChE activity was probably related to release of adrenaline from adrenal medulla.	Epinephrine	62-72	butyrylcholinesterase	Rattus norvegicus	14-17
580191-0	1978	Inhibition of cholinesterase by epinephrine and norepinephrine.	Epinephrine	32-43	butyrylcholinesterase	Homo sapiens	14-28
580191-2	1978	The inhibition of acetylcholinesterase by low concentration of epinephrine or norepinephrine was found to follow first-order reaction kinetics.	Epinephrine	63-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
580191-3	1978	The constants characterising this inhibition, the bimolecular rate ka (51.8 M-1 min-1 for epinephrine and 15.9 M-1 min-1 for norepinephrine) and the enzyme inhibitor dissociation constant (8.52 mM for epinephrine and 12.2 mM norepinephrine) were determined.	Epinephrine	90-101	CD59 molecule (CD59 blood group)	Homo sapiens	80-85
580191-4	1978	The inhibition of acetylcholinesterase by epinephrine was found to be of the mixed type while its inhibition by norepinephrine was of the competitive type.	Epinephrine	42-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-38
215492-0	1978	Insulin alteration of epinephrine action on the heart.	Epinephrine	22-33	insulin	Homo sapiens	0-7
658786-3	1978	Addition of human fibrinogen to the Tyrode-suspending buffer was required for ADP and epinephrine, but was not necessary for trypsin or collagen.	Epinephrine	86-97	fibrinogen beta chain	Homo sapiens	18-28
650890-4	1978	Epinephrine, however, induced an increase in lipase activity and in the amount of fatty acid released from the adipose tissue.	Epinephrine	0-11	lipase G, endothelial type	Rattus norvegicus	45-51
203575-2	1978	Rats injected intravenously with 1 microgram of purified IAP exhibited markedly enhanced insulin secretory responses to glucose, glucagon, epinephrine, and sulfonylureas over a period from 3 to 10 days after the injection.	Epinephrine	139-150	Cd47 molecule	Rattus norvegicus	57-60
203575-4	1978	There was a highly significant correlation between the enhancement of insulin secretion and suppression of epinephrine hyperglycemia over a wide range of doses of IAP, indicating that suppression of epinephrine hyperglycemia resulted from hypoglycemic action of insulin secreted in response to epinephrine challenge.	Epinephrine	107-118	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	163-166
203575-4	1978	There was a highly significant correlation between the enhancement of insulin secretion and suppression of epinephrine hyperglycemia over a wide range of doses of IAP, indicating that suppression of epinephrine hyperglycemia resulted from hypoglycemic action of insulin secreted in response to epinephrine challenge.	Epinephrine	199-210	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	Mus musculus	163-166
589478-4	1977	Epinephrine levels are markedly increased in ganglia of NGF-treated rats younger than one week of age, but at older ages the levels of the catecholamine are only slightly greater than the controls.	Epinephrine	0-11	nerve growth factor	Rattus norvegicus	56-59
564531-3	1978	Oxytocin in doses up to 500 mU/ml had no effect on PGF accumulation in the incubation period at any stage of the cycle, while epinephrine (10(-3)) greatly stimulated PGF release from the estrous uterus but had no effect on PGF release from the diestrous uterus.	Epinephrine	126-137	placental growth factor	Rattus norvegicus	166-169
564531-3	1978	Oxytocin in doses up to 500 mU/ml had no effect on PGF accumulation in the incubation period at any stage of the cycle, while epinephrine (10(-3)) greatly stimulated PGF release from the estrous uterus but had no effect on PGF release from the diestrous uterus.	Epinephrine	126-137	placental growth factor	Rattus norvegicus	166-169
564531-4	1978	Phentolamine, an alpha-blocking agent, had no effect on the epinephrine-induced release of PGF, while propranolol, a beta-blocking agent, not only prevented in increase in PGF production induced by epinephrine but also reduced the basal release of PGF by the estrous uterus.	Epinephrine	198-209	placental growth factor	Rattus norvegicus	172-175
564531-4	1978	Phentolamine, an alpha-blocking agent, had no effect on the epinephrine-induced release of PGF, while propranolol, a beta-blocking agent, not only prevented in increase in PGF production induced by epinephrine but also reduced the basal release of PGF by the estrous uterus.	Epinephrine	198-209	placental growth factor	Rattus norvegicus	172-175
588376-3	1977	In patients with high plasma renin activity the excretion of noradrenaline and adrenaline was relatively high while that of dopamine was low.	Epinephrine	64-74	renin	Homo sapiens	29-34
607511-0	1977	The effect of somatostatin on epinephrine-induced free fatty acid release in normal man.	Epinephrine	30-41	somatostatin	Homo sapiens	14-26
415869-8	1977	Release of gastrin by adrenaline in the dog does not appear to be physiological since it is not achieved by the amount of adrenaline released in response to hypoglycaemia.	Epinephrine	22-32	gastrin	Canis lupus familiaris	11-18
202259-4	1977	Propyl 3,4,5-trihydroxybenzoate inhibited competitively the adrenaline oxidation by isolated NADPH--cytochrome c reductase (Ki 3.2--4.7 micrometer) and inhibited non-competitively the cytochrome c reduction (Ki 92--109 micrometer).	Epinephrine	60-70	cytochrome c, somatic	Homo sapiens	100-112
202259-4	1977	Propyl 3,4,5-trihydroxybenzoate inhibited competitively the adrenaline oxidation by isolated NADPH--cytochrome c reductase (Ki 3.2--4.7 micrometer) and inhibited non-competitively the cytochrome c reduction (Ki 92--109 micrometer).	Epinephrine	60-70	cytochrome c, somatic	Homo sapiens	184-196
202259-5	1977	In contrast with the process of electron transfer to cytochrome c, the rate of reduction of cytochrome P-450 and the rate of oxidation of adrenaline in liver microsomal fraction are correlated.	Epinephrine	138-148	cytochrome c, somatic	Homo sapiens	53-65
202259-5	1977	In contrast with the process of electron transfer to cytochrome c, the rate of reduction of cytochrome P-450 and the rate of oxidation of adrenaline in liver microsomal fraction are correlated.	Epinephrine	138-148	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	92-108
113217-7	1979	This difference is attributable to propranolol"s blockade of adrenaline"s vasodilating effect mediated by beta-2 receptors in the resistance vessels.	Epinephrine	61-71	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	106-112
930924-9	1977	(4) A protein binding derivative of norepinephrine or epinephrine was identified as transferrin.	Epinephrine	39-50	transferrin	Homo sapiens	84-95
201552-1	1977	The inhibitory effect of epinephrine on basal and tolbutamide-stimulated insulin release was studied in 5 patients with hyperinsulinemic hypoglycemia.	Epinephrine	25-36	insulin	Homo sapiens	73-80
338214-6	1977	Glucocorticoids cause the induction of the enzyme noradrenaline N-methyltransferase, and so are particularly important for the synthesis of epinephrine.	Epinephrine	140-151	phenylethanolamine N-methyltransferase	Homo sapiens	50-83
201552-2	1977	Epinephrine inhibited both basal and tolbutamide-induced insulin release in patients with beta-cell adenoma and hyperplasia, but failed to inhibit insulin release in a patient with beta-cell carcinoma.	Epinephrine	0-11	insulin	Homo sapiens	57-64
201552-3	1977	The inhibition of basal insulin with epinephrine was maximum in patients with beta-cell hyperplasia.	Epinephrine	37-48	insulin	Homo sapiens	24-31
201552-4	1977	This differential inhibitory effect of epinephrine on insulin release may prove to be a useful screening test in the preoperative diagnosis of the nature of the lesion producing hyperinsulinemia.	Epinephrine	39-50	insulin	Homo sapiens	54-61
22953-8	1977	Results of the experiments with administration of adrenomimetic drugs suggested that adrenaline and noradrenaline-isadrine had different sites of attachment through which they mediated their action on aspartate aminotransferase in rat heart mitochondria.	Epinephrine	85-95	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	201-227
200741-3	1977	Norepinephrine restores the blood calcium effects of PTH in these cases but epinephrine is inactive.	Epinephrine	3-14	LOW QUALITY PROTEIN: parathyroid hormone	Cavia porcellus	53-56
874102-8	1977	Perifusion with adenosine deaminase significantly increased basal lipolysis to 30% of the epinephrine response.	Epinephrine	90-101	adenosine deaminase	Rattus norvegicus	16-35
908468-1	1977	Insulin resistance was measured in 16 normal dogs by a method involving the continuous intravenous infusion of epinephrine, propranolol, glucose and insulin.	Epinephrine	111-122	insulin	Canis lupus familiaris	0-7
874246-3	1977	Insulin resistance was estimated by measuring the steady-state plasma glucose response to a continuous infusion of insulin, glucose, epinephrine, and propranolol.	Epinephrine	133-144	insulin	Homo sapiens	0-7
70475-5	1977	In the present investigation, CRP was found by direct assay to inhibit the release of endogenous ADP and/or serotonin concomitant with inhibition of platelet aggregation stimulated by ADP, epinephrine, thrombin, and AHGG.	Epinephrine	189-200	C-reactive protein	Homo sapiens	30-33
20213-4	1977	While in the hypothyroid animals at 4 degrees C the concentration of adrenal catecholamines was less, the epinephrine to norepinephrine ratio was higher than at 23 degrees C. Very high TH activity with a decline in catecholamine concentration suggests that the capacity of TH had been exceeded.	Epinephrine	106-117	tyrosine hydroxylase	Rattus norvegicus	185-187
874102-9	1977	Adenosine deaminase and epinephrine were synergistic in stimulating lipolysis to 180% of the response to epinephrine alone.	Epinephrine	105-116	adenosine deaminase	Rattus norvegicus	0-19
196153-0	1977	Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the  brain.	Epinephrine	93-104	phenylethanolamine N-methyltransferase	Homo sapiens	10-48
196153-0	1977	Effect of phenylethanolamine N-methyltransferase and dopamine-beta-hydroxylase inhibition on epinephrine levels in the  brain.	Epinephrine	93-104	dopamine beta-hydroxylase	Homo sapiens	53-78
890570-0	1977	The effect of some phenylethanolamine N-methyltransferase inhibitors on the adrenaline content in the domestic fowl diencephalon.	Epinephrine	76-86	phenylethanolamine N-methyltransferase	Homo sapiens	19-57
198028-3	1977	Propylgallate competitively inhibits the reaction of adrenaline oxidation by isolated DADPH-cytochrome c reductase and non-competitively suppress the reaction of cytochrome c reduction.	Epinephrine	53-63	cytochrome c, somatic	Homo sapiens	92-104
198028-4	1977	In contrast to the process of electron transfer on cytochrome c, there is a direct correlation between the rate of cytochrome P-450 reduction and the rate of adrenaline oxidation in liver microsomes.	Epinephrine	158-168	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-131
918958-3	1977	The greater the amount of intraarticularly injected steroids was and the more severe the stage and class of rheumatoid arthritis were, the lower the level of adrenaline was and the more reduced the activity of phenylethanolamine-N-methyltransferase was.	Epinephrine	158-168	phenylethanolamine N-methyltransferase	Homo sapiens	210-248
578021-2	1977	Epinephrine, known to potentiate and elicit aggregation of human platelets, was shown to inhibit thrombin-induced aggregation of rat platelets, delaying the onset of aggregation from 2 to 12 times.	Epinephrine	0-11	coagulation factor II, thrombin	Homo sapiens	97-105
578032-8	1977	The results suggest that the activation pathways for changes in factor VIII and euglobulin lysis time induced by adrenaline are separate.	Epinephrine	113-123	coagulation factor VIII	Canis lupus familiaris	64-75
882717-4	1977	During secretin and a combined secretin-epinephrine infusion there was a significant rise in serum gastrin concentration.	Epinephrine	40-51	gastrin	Oryctolagus cuniculus	99-106
189836-1	1977	The time course for epinephrine stimulation of lypolysis, cyclic AMP accumulation and activation of protein kinase was studied in adipose tissue from hypophysectomized rats.	Epinephrine	20-31	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	100-114
406652-5	1977	These data provide evidence that the PNMT receptor sites for SK&amp;F 64139 do not differ substantially from species to species and suggest the general utility of this drug as an inhibitor of adrenal epinephrine biosynthesis.	Epinephrine	200-211	phenylethanolamine N-methyltransferase	Homo sapiens	37-41
876399-1	1977	SK&amp;F 64139, an inhibitor of adrenal phenylethanolamine N-methyltransferase (PNMT), was found to significantly decrease 2-deoxy-D-glucose (2-DG) induced epinephrine excretion in the conscious rat under conditions where the former agent was administered chromically at 50 and 200 mg/kg/day over a 12-day period and 2-DG was administered after 3, 7 and 11 days of treatment.	Epinephrine	156-167	phenylethanolamine-N-methyltransferase	Rattus norvegicus	40-78
876399-1	1977	SK&amp;F 64139, an inhibitor of adrenal phenylethanolamine N-methyltransferase (PNMT), was found to significantly decrease 2-deoxy-D-glucose (2-DG) induced epinephrine excretion in the conscious rat under conditions where the former agent was administered chromically at 50 and 200 mg/kg/day over a 12-day period and 2-DG was administered after 3, 7 and 11 days of treatment.	Epinephrine	156-167	phenylethanolamine-N-methyltransferase	Rattus norvegicus	80-84
189836-5	1977	Peak levels of cyclic AMP, steady state levels of protein kinase activity and the rate of glycerol production were all related in a dose dependent manner to the concentration of epinephrine.	Epinephrine	178-189	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	50-64
869996-6	1977	Factor VIII rose c. 2.5 X with adrenaline but only c. 1.5 X with isoprenaline and salbutamol; but other clotting factors did not alter.	Epinephrine	31-41	cytochrome c oxidase subunit 8A	Homo sapiens	7-11
844018-2	1977	The possible causative mechanism was thought to be a reactive relative increase in insulin production secondary to increased endogenous production of glucose, induced by the large amounts of epinephrine produced by the tumour.	Epinephrine	191-202	insulin	Homo sapiens	83-90
844018-3	1977	Alternatively, epinephrine withdrawal following removal of the tumour under phentolamine infusion may have induced increased insulin production and hence potentiated the development of hypoglycemia.	Epinephrine	15-26	insulin	Homo sapiens	125-132
831826-5	1977	Methylation of both tRNA and histone by liver enzyme was inhibited by L-dopa, dopamine and epinephrine.	Epinephrine	91-102	Trng	Rattus norvegicus	20-24
831826-5	1977	Methylation of both tRNA and histone by liver enzyme was inhibited by L-dopa, dopamine and epinephrine.	Epinephrine	91-102	H2B clustered histone 1	Rattus norvegicus	29-36
188956-10	1977	In all groups, there was a negative correlation between the log concentration of epinephrine required to produce complete platelet aggregation and the platelet C/PL (r = -0.06; p less than 0.002).	Epinephrine	81-92	hephaestin	Homo sapiens	160-164
617782-3	1977	Autoprothrombin II-A reduced the sensitivity of platelets to aggregate with thrombin, but enhanced epinephrine-mediated aggregation.	Epinephrine	99-110	protein C, inactivator of coagulation factors Va and VIIIa	Canis lupus familiaris	0-20
189821-2	1977	The glycolysis inhibitors, NaF and monoiodoacetate, inhibited epinephrine or theophylline-stimulated lipolysis and parallely reduced the intracellular cyclic AMP and ATP levels; however, neither NaF nor monoidoacetate significantly affected dibutyryl cyclic AMP-induced lipolysis.	Epinephrine	62-73	C-X-C motif chemokine ligand 8	Homo sapiens	27-30
190256-8	1977	The adenylate cyclase of two ectopic ACTH producing tumors (gastric carcinoid and malignant thymoma) was activated by TRH, LH-RH, norepinephrine, epinephrine, serotonin, PGE1 and MEE.	Epinephrine	133-144	proopiomelanocortin	Homo sapiens	37-41
869996-11	1977	The rise in factor-VIII clotting activity after adrenaline is considered to represent a real increase in blood concentration, presumably by release of additional factor VIII from stores.	Epinephrine	48-58	cytochrome c oxidase subunit 8A	Homo sapiens	19-23
869996-11	1977	The rise in factor-VIII clotting activity after adrenaline is considered to represent a real increase in blood concentration, presumably by release of additional factor VIII from stores.	Epinephrine	48-58	cytochrome c oxidase subunit 8A	Homo sapiens	169-173
350523-3	1977	Conversely, the hyperglycaemia which accompanies sympathetic overactivity is accompanied by reduced plasma insulin levels because adrenaline inhibits pancreatic insulin by an alpha-adrenergic mechanism.	Epinephrine	130-140	insulin	Homo sapiens	107-114
863293-3	1977	Based on these figures, we observed that adult PRP was about 2.5 times more sensitive to ADP, at least 10 times to epinephrine and 2.3 times to collagen than neonatal PRP.	Epinephrine	115-126	prion protein	Homo sapiens	47-50
16354-0	1977	[Possible role of adrenaline in the mechanism of stimulation of gastrin synthesis and secretion].	Epinephrine	18-28	gastrin	Homo sapiens	64-71
13495-5	1977	In view of these findings it is suggested that a beta1 selective blocker may be a more efficient antianginal agent than a nonselective blocker in those patients in which the anginal attack is associated with a significant release of adrenaline.	Epinephrine	233-243	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	49-54
11915-3	1976	The compound increased basal and epinephrine-stimulated enzyme activity by about 300%; in addition GMP(PNP) increased hormone sensitivity by reducing the epinephrine concentration required, to produce half maximal stimulation.	Epinephrine	154-165	purine nucleoside phosphorylase	Homo sapiens	99-107
11915-4	1976	The rate of GMP(PNP)-induced activation was slow in onset and could be enhanced by epinephrine.	Epinephrine	83-94	purine nucleoside phosphorylase	Homo sapiens	16-19
1071652-2	1976	Intravenous administration of angiotensin II reduced the adrenaline content, increased the catechol-O-methyltransferase activity, and decreased the monoamine oxidase activity of rat hypothalamus.	Epinephrine	57-67	angiotensinogen	Rattus norvegicus	30-44
1071664-4	1976	When the injections were made into the bathing blood close to the everted rat aorta, angiotensin II was half as potent as adrenaline or noradrenaline on a molar basis.	Epinephrine	122-132	angiotensinogen	Rattus norvegicus	85-99
186790-2	1976	The concentrations by bioassay of nerve growth factor in both epinephrine- and norepinephrine-induced saliva (3400 and 900 mug/ml, respectively) are higher than reported in any other source.	Epinephrine	62-73	nerve growth factor	Mus musculus	34-53
993649-4	1976	Exposure to low insulin prior to or simultaneously with epinephrine produced a greater amount of antilipolysis than the addition of insulin to cells already stimulated by epinephrine.	Epinephrine	56-67	insulin	Homo sapiens	16-23
993649-4	1976	Exposure to low insulin prior to or simultaneously with epinephrine produced a greater amount of antilipolysis than the addition of insulin to cells already stimulated by epinephrine.	Epinephrine	171-182	insulin	Homo sapiens	132-139
993649-6	1976	Insulin (50 muU per milliliter) when given prior to or simultaneously with 0.035 mug per milliliter of epinephrine bitartrate completely blocked lipolysis but the antilipolytic effect of insulin could be overcome by increasing the concentration of epinephrine bitartrate.	Epinephrine	103-125	insulin	Homo sapiens	0-7
993649-6	1976	Insulin (50 muU per milliliter) when given prior to or simultaneously with 0.035 mug per milliliter of epinephrine bitartrate completely blocked lipolysis but the antilipolytic effect of insulin could be overcome by increasing the concentration of epinephrine bitartrate.	Epinephrine	248-270	insulin	Homo sapiens	0-7
993649-7	1976	Insulin (50 muU per milliliter) also decreased the sensitivity of the fat cells to subsequent doses of epinephrine bitartrate even after apparent removal of all immunoreactive insulin by continuing buffer infusion.	Epinephrine	103-125	insulin	Homo sapiens	0-7
993649-8	1976	After exposure to 50 muU per milliliter of insulin, followed by buffer alone, the cells failed to release glycerol in response to 0.035 mug per milliliter of epinephrine bitartrate but did respond to 3.5 mug per milliliter of epinephrine bitartrate.	Epinephrine	226-237	insulin	Homo sapiens	43-50
186254-1	1976	Ovine growth hormone (1 mug/ml) antagonized the lipolytic action of epinephrine (0.25 mug/ml) in segments of adipose tissue obtained from hypophysectomized rats, but a lag period of about 10 min was required.	Epinephrine	68-79	growth hormone 1	Rattus norvegicus	6-23
186254-3	1976	Only when tissues were exposed to epinephrine 15 min after preincubation with growth hormone was cyclic AMP accumulation compromised.	Epinephrine	34-45	gonadotropin releasing hormone receptor	Rattus norvegicus	78-92
186254-7	1976	Growth hormone added simultaneously with epinephrine or 30 min later significantly decreased the activity of protein kinase assayed in the absence of exogenous cyclic AMP, but did not change total protein kinase activity as measured in the presence of a saturating concentration of cyclic AMP.	Epinephrine	41-52	gonadotropin releasing hormone receptor	Rattus norvegicus	0-14
1088480-5	1976	In the presence of epinephrine, the low concentration (50 microunits/ml) of insulin induces the decrease of the content of glucose-6-phosphate.	Epinephrine	19-30	insulin	Homo sapiens	76-83
12423-4	1976	Principally, TH was present in neuron systems with a distribution similar to known dopamine, noradrenaline and adrenaline systems.	Epinephrine	96-106	tyrosine hydroxylase	Rattus norvegicus	13-15
825786-0	1976	The long term effects of an inhibitor of phenylethanolamine N-methyltransferase upon adrenal epinephrine biosynthesis.	Epinephrine	93-104	phenylethanolamine-N-methyltransferase	Rattus norvegicus	41-79
825786-1	1976	Chronic administration of SK&amp;F 64139, an inhibitor of phenylethanolamine N-methyltransferase (PNMT), initially resulted in a lowered adrenal epinephrine content in both the rat and squirrel monkey adrenal gland.	Epinephrine	145-156	phenylethanolamine-N-methyltransferase	Rattus norvegicus	58-96
825786-1	1976	Chronic administration of SK&amp;F 64139, an inhibitor of phenylethanolamine N-methyltransferase (PNMT), initially resulted in a lowered adrenal epinephrine content in both the rat and squirrel monkey adrenal gland.	Epinephrine	145-156	phenylethanolamine-N-methyltransferase	Rattus norvegicus	98-102
825786-4	1976	These results suggest that long-term pharmacological PNMT inhibition may evoke compensatory mechanisms to maintain adrenal epinephrine biosynthesis under basal laboratory conditions.	Epinephrine	123-134	phenylethanolamine-N-methyltransferase	Rattus norvegicus	53-57
186790-4	1976	The specific activity of the salivary nerve growth factor was 41, 36, 2, and 0.6 mug/mg of protein in secretions elicited by epinephrine, norepinephrine, pilocarpine, and isoproterenol, respectively.	Epinephrine	125-136	nerve growth factor	Mus musculus	38-57
9149-4	1976	During the early phases of thrombin-and ADP-induced platelet aggregation a marked activation of the guanylate cyclase occurs whereas aggregation induced by arachidonic acid or epinephrine results in a rapid diminution of this activity.	Epinephrine	176-187	coagulation factor II, thrombin	Homo sapiens	27-35
790976-2	1976	Continuous challenge with ACh produces a biphasic insulin release response, both phases of which are reduced when the medium calcium concentration is reduced during stimulation; when the calcium content is reduced during an initial perifusion period of 30 min and then replaced during subsequent stimulation only the first phase of the response to ACh is affected; perifusion with epinephrine prior to stimulation with ACh produces enhancement of both phases of ACh-induced insulin release when calcium in both media is normal.	Epinephrine	381-392	insulin	Homo sapiens	50-57
790976-3	1976	However,.when this experiment is repeated utilizing a medium with low calcium content during the period of exposure to epinephrine the priming effect of epinephrine on the subsequent insulin response to ACh is abolished (in fact, reversed).	Epinephrine	119-130	insulin	Homo sapiens	183-190
790976-3	1976	However,.when this experiment is repeated utilizing a medium with low calcium content during the period of exposure to epinephrine the priming effect of epinephrine on the subsequent insulin response to ACh is abolished (in fact, reversed).	Epinephrine	153-164	insulin	Homo sapiens	183-190
790976-4	1976	These studies provide direct evidence for a role for calcium in mediating an effect of epinephrine on insulin release.	Epinephrine	87-98	insulin	Homo sapiens	102-109
977255-0	1976	Potentiation of the effects of topical epinephrine on the pupil and intraocular pressure in the sympathetically denervated rabbit eye by a catechol-O-methyl transferase inhibitor.	Epinephrine	39-50	catechol O-methyltransferase	Oryctolagus cuniculus	139-168
977255-2	1976	Topical pretreatment with the catechol-O-methyl transferase inhibitor U-0521 potentiated the effects of epinephrine on both the pupil and pressure.	Epinephrine	104-115	catechol O-methyltransferase	Oryctolagus cuniculus	30-59
967013-5	1976	It was found that while these infusions failed to suppress glucagon release, the ketoacid infusion did significantly reduce epinephrine secretion during the insulin-induced hypoglycemic period.	Epinephrine	124-135	insulin	Canis lupus familiaris	157-164
977942-2	1976	Inhibition by CRP of platelet reactivities stimulated by poly-L-lysine, ADP, epinephrine, and collagen.	Epinephrine	77-88	C-reactive protein	Homo sapiens	14-17
977942-7	1976	CRP similarly inhibited ADP- and epinephrine-stimulated platelet aggregation in platelet-rich plasma (PRP), and this was characterized by relatively minimal suppression of the primary wave  of aggregation.	Epinephrine	33-44	C-reactive protein	Homo sapiens	0-3
977942-7	1976	CRP similarly inhibited ADP- and epinephrine-stimulated platelet aggregation in platelet-rich plasma (PRP), and this was characterized by relatively minimal suppression of the primary wave  of aggregation.	Epinephrine	33-44	complement component 4 binding protein alpha	Homo sapiens	102-105
955298-2	1976	Insulin resistance was estimated by measuring the steady-state plasma glucose response to a continuous infusion of insulin, glucose, epinephrine, and propranolol.	Epinephrine	133-144	insulin	Homo sapiens	0-7
186835-1	1976	Administration of epinephrine in man has been shown previously to lead to a rise in plasma cyclic AMP levels by activation of the beta-adrenergic-stimulated adenylate cyclase.	Epinephrine	18-29	adenine phosphoribosyltransferase	Homo sapiens	98-101
186835-2	1976	Therapeutic doses of lithium in humans block the epinephrine-induced rise in plasma cyclic AMP levels, suggesting that lithium inhibits beta-adrenergic adenylate cyclase.	Epinephrine	49-60	adenine phosphoribosyltransferase	Homo sapiens	91-94
186835-3	1976	In contrast, ten subjects receiving haloperidol, a druh also effective in the treatment of mania, show a mean rise in plasma cyclic AMP levels after epinephrine administration and the magnitude of the response is the same as for non-drug treated individuals.	Epinephrine	149-160	adenine phosphoribosyltransferase	Homo sapiens	132-135
1023189-2	1976	Intravenous injection of adrenalin (1--2 Mg/kg/min) caused an increase in the blood renin content and a reduction of the renal excretion of sodium, potassium and water.	Epinephrine	25-34	renin	Canis lupus familiaris	84-89
786348-1	1976	The addition of adrenaline 5 mug/ml, 1 : 200 000 to 1% etidocaine hydrochloride administered extradurally (L2-3) shortened significantly the onset time for sensory blockade, particularly with respect to the spread of the analgesia from the injection site, and shortened the already rapid onset of motor block.	Epinephrine	16-26	immunoglobulin kappa variable 1D-43	Homo sapiens	107-111
1018118-9	1976	Furthermore, it was found that the rate of adrenaline excretion was higher for both groups during Trip 2, when the train was more crowded.	Epinephrine	43-53	mediator complex subunit 1	Homo sapiens	98-104
939004-8	1976	Significant (P less than 0.05) inhibition of renin release was induced by l-epinephrine or l-norepinephrine (10(-5) M).	Epinephrine	74-87	renin	Rattus norvegicus	45-50
956686-6	1976	The mean threshold concentration of epinephrine necessary for aggregation of normal platelets (4.2 muM) was not significatnly increased with clofibrate (10 muM) but was markedly elevated with halofenate (245 muM; p less than 0.001).	Epinephrine	36-47	latexin	Homo sapiens	99-102
1027234-8	1976	Adrenaline promoted and isadrine inhibited the penetration of m-AAT into cytoplasma.	Epinephrine	0-10	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	64-67
180937-5	1976	Epinephrine stimulated adenyl cyclase activity of normal membranes two to three times, but did not stimulate the enzyme in Duchenne membranes.	Epinephrine	0-11	adenylate cyclase 1	Homo sapiens	23-37
1033105-5	1976	2) TLP-607 slightly hypertension induced by dopamine, adrenaline and noradrenaline, but had no effect on hypotension induced by acetylcholine and histamine.	Epinephrine	54-64	cysteine rich protein 3	Homo sapiens	3-6
181558-2	1976	Epinephrine produced a dose-dependent increase in both cyclin AMP and phosphorylase activity but no significant (P greater than .05) change in cyclic GMP levels.	Epinephrine	0-11	proliferating cell nuclear antigen	Rattus norvegicus	55-61
932031-6	1976	In contrast, 1.0 muM propranolol essentially completely inhibited the 8-fold stimulation of 1.0 muM epinephrine but had no effect on either basal or adenosine-stimulated activity.	Epinephrine	100-111	latexin	Homo sapiens	17-20
932031-6	1976	In contrast, 1.0 muM propranolol essentially completely inhibited the 8-fold stimulation of 1.0 muM epinephrine but had no effect on either basal or adenosine-stimulated activity.	Epinephrine	100-111	latexin	Homo sapiens	96-99
1030637-4	1976	The summation of oxygen uptake activities is observed on the combined action of catalase and ethanol with any of the Mehler reagents functioning in photosystem I (methylviologen,FMN, epinephrine, ferredoxin).	Epinephrine	183-194	catalase	Homo sapiens	80-88
1278114-3	1976	Dopamine, norepinephrine, and epinephrine were incubated with catechol-O-methyl transferase (COMT) and [3H]S-acenosyl methionine ([3H]SAM) and were converted to the O-methylated tritiated derivatives: [3H]methoxytyramine, [3H]normetanephrine, and [3H]metanephrine, respectively.	Epinephrine	13-24	catechol-O-methyltransferase	Rattus norvegicus	62-91
14500-3	1976	In those three patients with concomitant distinct hypersecretion of epinephrine, renin release (and aldosterone secretion except in one patient) was markedly enhanced.	Epinephrine	68-79	renin	Homo sapiens	81-86
180004-1	1976	Phenylalanine hydroxylase in Reuber H4 hepatoma cell cultures can be rapidly inactivated by the addition of epinephrine, norepinephrine, dopamine, or 3,4-dihydroxyphenylalanine, in order of decreasing effectiveness, to the culture medium.	Epinephrine	108-119	phenylalanine hydroxylase	Rattus norvegicus	0-25
180004-4	1976	Phenylalanine hydroxylase appears to be reversibly inactivated by epinephrine within the cells; since washing the compound off the cell cultures resulted in a rapid restoration of enzyme activity (40% in 1 hour), cycloheximide had little effect on the initial rate of recovery of enzyme activity and the same amount of phenylalanine hydroxylase antigen per cell was isolated from treated and normal cultures.	Epinephrine	66-77	phenylalanine hydroxylase	Rattus norvegicus	0-25
180004-6	1976	The possibility, suggested by the above results, that epinephrine might be directly inactivating phenylalanine hydroxylase within the cells was supported by the finding that purified rat liver phenylalanine hydroxylase would be 50% inactivated by 1.5 muM epinephrine in 10 min.	Epinephrine	54-65	phenylalanine hydroxylase	Rattus norvegicus	97-122
180004-6	1976	The possibility, suggested by the above results, that epinephrine might be directly inactivating phenylalanine hydroxylase within the cells was supported by the finding that purified rat liver phenylalanine hydroxylase would be 50% inactivated by 1.5 muM epinephrine in 10 min.	Epinephrine	54-65	phenylalanine hydroxylase	Rattus norvegicus	193-218
180004-6	1976	The possibility, suggested by the above results, that epinephrine might be directly inactivating phenylalanine hydroxylase within the cells was supported by the finding that purified rat liver phenylalanine hydroxylase would be 50% inactivated by 1.5 muM epinephrine in 10 min.	Epinephrine	255-266	phenylalanine hydroxylase	Rattus norvegicus	97-122
180004-6	1976	The possibility, suggested by the above results, that epinephrine might be directly inactivating phenylalanine hydroxylase within the cells was supported by the finding that purified rat liver phenylalanine hydroxylase would be 50% inactivated by 1.5 muM epinephrine in 10 min.	Epinephrine	255-266	phenylalanine hydroxylase	Rattus norvegicus	193-218
1084352-1	1976	Epinephrine infusion causes variable increases in the components of the Factor VIII (antihemophilic factor) complex in patients with von Willebrand"s disease.	Epinephrine	0-11	coagulation factor VIII	Homo sapiens	85-106
818909-7	1976	Epinephrine (40 muM), prostaglandin E1 (7 muM), or serotonin (2 muM) added before fixation caused slight to moderate inhibition but always less than ADP.	Epinephrine	0-11	latexin	Homo sapiens	16-19
176155-8	1976	A second effect of insulin was evident when epinephrine (10(-6) M) was present simultaneously.	Epinephrine	44-55	insulin	Homo sapiens	19-26
1261213-6	1976	Hormone-sensitive lipase activity was demonstrated in lipomas under basal conditions of assay as well as in the presence of adrenaline plus theophylline.	Epinephrine	124-134	lipase E, hormone sensitive type	Homo sapiens	0-24
179579-2	1976	This enzymatic activity is strongly stimulated by NaF and 5"-guanylimidodiphosphate, is slightly stimulated by epinephrine, norepinephrine, isoproterenol, and prostaglandin E1 and is inhibited by calcium.	Epinephrine	111-122	C-X-C motif chemokine ligand 8	Homo sapiens	50-53
176155-10	1976	Nevertheless, persistence of insulin-stimulated phosphorylation of the 123,000 peptide in the presence of epinephrine was shown by a 32P content of this peptide that was greater in the presence of both hormones than with either individually.	Epinephrine	106-117	insulin	Homo sapiens	29-36
176155-9	1976	Insulin significantly inhibited the epinephrine-stimulated phosphorylation of the molecular weight 69,000 (endoplasmic reticulum, cytoplasm) and 26,000 (plasma membrane) peptides.	Epinephrine	36-47	insulin	Homo sapiens	0-7
1252615-2	1976	This reaction was abolished by superoxide dismutase and catalase, but not by albumin or boiled dismutase, indicating that epinephrine oxidation was dependent on O2- AND H2O2.	Epinephrine	122-133	catalase	Homo sapiens	56-64
1259204-2	1976	The antagonism between epinephrine and insulin, as suggested by Konig in 1935, is indeed accurate.	Epinephrine	23-34	insulin	Homo sapiens	39-46
1248452-3	1976	When glucose was given during phentolamine administration, insulin levels rose more in the epinephrine-treated animals than in the hypoxic animals, despite similar blood glucose levels.	Epinephrine	91-102	insulin	Homo sapiens	59-66
179611-9	1976	The homogenate incubation in a medium containing 10(-5) M epinephrine or 10(-7) M caffeine and 5 mM Mg2+ leads to an increase in the GAMT activity.	Epinephrine	58-69	guanidinoacetate N-methyltransferase	Rattus norvegicus	133-137
176668-5	1976	The stimulatory action of cholinergic agents and the inhibitory action of epinephrine are accompanied by the accumulation of cyclic GMP and cyclic AMP, respectively, in human neutrophils.	Epinephrine	74-85	5'-nucleotidase, cytosolic II	Homo sapiens	132-135
9301-12	1976	Despite the marked increase in plasma adrenaline following insulin-induced hypoglycemia, no statistically significant increase in pulse rate was recorded.	Epinephrine	38-48	insulin	Homo sapiens	59-66
1248452-4	1976	Theophylline-induced insulin release was increased by epinephrine, but inhibited by hypoxia.	Epinephrine	54-65	insulin	Homo sapiens	21-28
1248452-5	1976	When the beta adrenergic blocking agent, propranolol, was given with the epinephrine, the insulin response to theophylline was markedly reduced and similar to that observed during hypoxia.	Epinephrine	73-84	insulin	Homo sapiens	90-97
999466-3	1976	The influence of bradykinin and kallikrein on the action of norepinephrine, epinephrine, isoprenaline, phentolamine, propranolol, aminophylline and theophylline on blood pressure was studied.	Epinephrine	63-74	kallikrein related peptidase 4	Homo sapiens	32-42
6242-5	1976	A non-selective and a beta1-selective blocker may have different haemodynamic effects when the levels of circulating adrenaline are high, because of their markedly different potency in inhibiting the beta2-mediated vasodilator effect of adrenaline.	Epinephrine	117-127	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	22-27
971551-9	1976	Release of renin was directly proportional to the number of glomeruli and could be stimulated by isoprenaline, adrenaline and noradrenaline in order of the potency of their action on beta-adrenoreceptors.	Epinephrine	111-121	renin	Rattus norvegicus	11-16
1247673-1	1976	In the presence of EDTA soluble antioxidants (1 muM reduced glutathion, 3 muM cystein, 1 muM ascorbic acid) inhibited the autoxidation of epinephrine at pH 10.2; as to alpha-tocopherol (40 muM) and the oxidative forms of these antioxidants - they were ineffective.	Epinephrine	138-149	latexin	Homo sapiens	48-51
1247673-1	1976	In the presence of EDTA soluble antioxidants (1 muM reduced glutathion, 3 muM cystein, 1 muM ascorbic acid) inhibited the autoxidation of epinephrine at pH 10.2; as to alpha-tocopherol (40 muM) and the oxidative forms of these antioxidants - they were ineffective.	Epinephrine	138-149	latexin	Homo sapiens	74-77
1247673-1	1976	In the presence of EDTA soluble antioxidants (1 muM reduced glutathion, 3 muM cystein, 1 muM ascorbic acid) inhibited the autoxidation of epinephrine at pH 10.2; as to alpha-tocopherol (40 muM) and the oxidative forms of these antioxidants - they were ineffective.	Epinephrine	138-149	latexin	Homo sapiens	74-77
1247673-1	1976	In the presence of EDTA soluble antioxidants (1 muM reduced glutathion, 3 muM cystein, 1 muM ascorbic acid) inhibited the autoxidation of epinephrine at pH 10.2; as to alpha-tocopherol (40 muM) and the oxidative forms of these antioxidants - they were ineffective.	Epinephrine	138-149	latexin	Homo sapiens	74-77
6242-5	1976	A non-selective and a beta1-selective blocker may have different haemodynamic effects when the levels of circulating adrenaline are high, because of their markedly different potency in inhibiting the beta2-mediated vasodilator effect of adrenaline.	Epinephrine	117-127	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	200-205
177469-1	1976	The time course of the action of epinephrine on cAMP levels in isolated mouse Ehrlich ascites cells was studied.	Epinephrine	33-44	cathelicidin antimicrobial peptide	Mus musculus	48-52
182484-1	1976	Glucagon, epinephrine and cyclic adenosine 3",5"-monophosphate (cyclic AMP) prevented the induction of liver glucose-6-phosphate dehydrogenase (G6PD) by refeeding a glucose-casein mixture to starved rats.	Epinephrine	10-21	glucose-6-phosphate dehydrogenase	Rattus norvegicus	109-142
182484-1	1976	Glucagon, epinephrine and cyclic adenosine 3",5"-monophosphate (cyclic AMP) prevented the induction of liver glucose-6-phosphate dehydrogenase (G6PD) by refeeding a glucose-casein mixture to starved rats.	Epinephrine	10-21	glucose-6-phosphate dehydrogenase	Rattus norvegicus	144-148
821893-6	1976	Epinephrine also antagonizes insulin action.	Epinephrine	0-11	insulin	Homo sapiens	29-36
765118-8	1976	Infusion of norepinephrine or epinephrine partially suppressed the prolactin rise but only after 2 h of infusion.	Epinephrine	15-26	prolactin	Rattus norvegicus	67-76
177469-4	1976	Experiments involving timed additions of theophylline to epinephrine-treated cells suggested that the rate of cAMP synthesis declined progressively with time.	Epinephrine	57-68	cathelicidin antimicrobial peptide	Mus musculus	110-114
173740-7	1976	Although epinephrine stimulated adenylate cyclase 8-fold and fluoride 12-fold throughout the life-span of the rat, stimulated activity paralleled basal levels, decreasing 60% between 2 and 24 mo per mg protein and 40% between 6 and 24 mo per cell.	Epinephrine	9-20	adenylate cyclase 8	Rattus norvegicus	32-51
177469-5	1976	Cells treated with epinephrine and then washed free of hormone were shown to be refractory to hormonal stimulation of cAMP levels.	Epinephrine	19-30	cathelicidin antimicrobial peptide	Mus musculus	118-122
1064147-0	1976	Effect of epinephrine and norepinephrine on gastrin release and gastric secretion of acid in man.	Epinephrine	10-21	gastrin	Homo sapiens	44-51
1265094-3	1976	In the present study driven atrial strips removed from stressed male CSF rats were found to exhibit an enhanced sensitivity to both norepinephrine and epinephrine.	Epinephrine	135-146	colony stimulating factor 2	Rattus norvegicus	69-72
1064147-2	1976	Two doses were used (5 and 50 mg per kg per minute in one hour), the low dose of epinephrine and both doses of epinephrine (n=20) stimulated gastrin release and acid secretion, whereas the high dose (n=8) stimulated the gastrin release strongly, but did not change acid secretion.	Epinephrine	81-92	gastrin	Homo sapiens	141-148
1064147-2	1976	Two doses were used (5 and 50 mg per kg per minute in one hour), the low dose of epinephrine and both doses of epinephrine (n=20) stimulated gastrin release and acid secretion, whereas the high dose (n=8) stimulated the gastrin release strongly, but did not change acid secretion.	Epinephrine	111-122	gastrin	Homo sapiens	141-148
1064147-5	1976	It is concluded that epinephrine and norepinephrine both may be of importance in the physiological regulation of gastrin release and gastric acid secretion.	Epinephrine	21-32	gastrin	Homo sapiens	113-120
241760-4	1975	Both epinephrine and isoproterenol, a beta agonist, inhibited skin reactions produced by antigen or histamine.	Epinephrine	5-16	amyloid beta precursor protein	Homo sapiens	36-42
1204291-0	1975	The stimulation of renin secretion by non-vasocontrictor infusions of adrenaline and noradrenaline in the isolated rat kidney.	Epinephrine	70-80	renin	Rattus norvegicus	19-24
1204291-4	1975	Under these conditions adrenaline and noradrenaline significantly increased renin secretion rates, compared with control experiments in which no catecholamine was infused.	Epinephrine	23-33	renin	Rattus norvegicus	76-81
187436-4	1975	Block of COMT enhanced the effects of adrenaline approximately as much as did the blockade of neuronal uptake; this seems to indicate that the affinity of adrenaline for extraneuronal and neuronal uptake processes is approximately the same.	Epinephrine	38-48	catechol-O-methyltransferase	Canis lupus familiaris	9-13
187436-4	1975	Block of COMT enhanced the effects of adrenaline approximately as much as did the blockade of neuronal uptake; this seems to indicate that the affinity of adrenaline for extraneuronal and neuronal uptake processes is approximately the same.	Epinephrine	155-165	catechol-O-methyltransferase	Canis lupus familiaris	9-13
1186497-1	1975	The effect of somatostatin, on the secretion of noradrenaline and adrenaline was studied in eight normal subjects during exercise and in insulin induced hypoglycemia.	Epinephrine	51-61	somatostatin	Homo sapiens	14-26
1186497-4	1975	During the infusion of somatostatin the secretion of adrenaline was increased.	Epinephrine	53-63	somatostatin	Homo sapiens	23-35
1186497-6	1975	The blood glucose concentration attained after insulin injection was lower during the infusion of somatostatin and evidence is presented which indicates that the higher adrenaline values during hypoglycemia were due to the lower blood glucose values attained.	Epinephrine	169-179	somatostatin	Homo sapiens	98-110
242278-3	1975	The response to adrenaline could be blocked by phentolamine, an alpha-inhibitor, while propranolol, a beta inhibitor, had no effect.--The response to terbutaline was blocked by atropine and partly by practolol, a beta-inhibitor.	Epinephrine	16-26	amyloid beta precursor protein	Homo sapiens	211-217
1209687-9	1975	The results suggest that exogenous progesterone administration during late pregnancy increases epinephrine stores by declining monoamine metabolism by MAO and COMT and increasing their synthesis by PNMT which is responsible for N-methylation of norepinephrine to epinephrine.	Epinephrine	95-106	monoamine oxidase A	Rattus norvegicus	151-154
1209687-9	1975	The results suggest that exogenous progesterone administration during late pregnancy increases epinephrine stores by declining monoamine metabolism by MAO and COMT and increasing their synthesis by PNMT which is responsible for N-methylation of norepinephrine to epinephrine.	Epinephrine	95-106	catechol-O-methyltransferase	Rattus norvegicus	159-163
1209687-9	1975	The results suggest that exogenous progesterone administration during late pregnancy increases epinephrine stores by declining monoamine metabolism by MAO and COMT and increasing their synthesis by PNMT which is responsible for N-methylation of norepinephrine to epinephrine.	Epinephrine	95-106	phenylethanolamine-N-methyltransferase	Rattus norvegicus	198-202
1209687-9	1975	The results suggest that exogenous progesterone administration during late pregnancy increases epinephrine stores by declining monoamine metabolism by MAO and COMT and increasing their synthesis by PNMT which is responsible for N-methylation of norepinephrine to epinephrine.	Epinephrine	248-259	phenylethanolamine-N-methyltransferase	Rattus norvegicus	198-202
1102318-1	1975	Plasma adrenaline-blood glucose interrelationships in insulin-induced hypoglycaemia in man have been studied using a sensitive double-isotope derivative method for adrenaline estimation.	Epinephrine	7-17	insulin	Homo sapiens	54-61
1234578-17	1975	The results suggest that insulin indirectly stimulates carbohydrate oxidation by facilitating glucose transport into the cells and lowering FFA levels, and that epinephrine favours lipid oxidation through its lipolytic effects and its suppression of insulin release.	Epinephrine	161-172	insulin	Homo sapiens	250-257
1102318-2	1975	Plasma adrenaline reached a peak of 1.24 ng/ml at 45 minutes after insulin while blood glucose reached a nadir of 22 mg/100 ml at 30 minutes.	Epinephrine	7-17	insulin	Homo sapiens	67-74
1157220-4	1975	Significant dose-related stimulation of renin release was observed with epinephrine and norepinephrine in concentrations from 1.5 times 10(-9) to 1.5 times 10(-7)M and with isoproterenol in concentrations from 2 times 10(-9) to 2 times 10(-7)M. No significant stimulation was seen with 10(-10)M concentrations of the three agents.	Epinephrine	72-83	renin	Rattus norvegicus	40-45
1183916-5	1975	Hypoglycemia-induced increases in epinephrine and glucagon, secretion may contribute to the restoration of the normal plasma glucose concentration after insulin-induced hypoglycemia.	Epinephrine	34-45	insulin	Homo sapiens	153-160
1228339-4	1975	The mean SOD activity, assayed by inhibition of epinephrine autoxidation, was 415 +/- 66 units/g cells or 50 +/- 11 units/mg non-Hb protein.	Epinephrine	48-59	superoxide dismutase 1	Homo sapiens	9-12
168295-8	1975	It appears likely that the adrenal medulla is a target for corticosterone which probably regulates the tissue levels of phenylethanolamine-N-methyltransferase, one of the enzymes necessary for the biosynthesis of adrenaline.	Epinephrine	213-223	phenylethanolamine N-methyltransferase	Gallus gallus	120-158
1181275-7	1975	However isopentyl-guanidine and butylbiguanide followed the effect of adrenalin: they additionally lowered the ATP level and therefore they acted in opposition to insulin.	Epinephrine	70-79	insulin	Homo sapiens	163-170
1173505-4	1975	When the insulin response to the first glucose infusion was suppressed by 65% with the aid of adrenaline, potentiation of the insulin response to the second infusion was not modified.	Epinephrine	94-104	insulin	Homo sapiens	9-16
1173505-4	1975	When the insulin response to the first glucose infusion was suppressed by 65% with the aid of adrenaline, potentiation of the insulin response to the second infusion was not modified.	Epinephrine	94-104	insulin	Homo sapiens	126-133
1191576-1	1975	Adrenaline, nicotinic acid (NA), vasopressin (LVP) and other drugs affecting vascular motility are known to increase plasminogen activator (PA) and factor-VIII plasma levels in man.	Epinephrine	0-10	cytochrome c oxidase subunit 8A	Homo sapiens	155-159
170700-2	1975	Incubation of rat lung with adrenaline, a beta adrenergic agent, produced a rapid increase in cyclic AMP, 100% increase at 15 seconds and 340% at 2 minutes.	Epinephrine	28-38	amyloid beta precursor protein	Rattus norvegicus	40-46
168084-4	1975	Adipocytes of women at the end of pregnancy exhibited higher rates of lipolysis in response to adrenaline (1.5 - 15 muM) plus phentolamine (13 muM) than those of non-pregnant women or those in early pregnancy.	Epinephrine	95-105	latexin	Homo sapiens	116-119
168084-12	1975	Cell levels of cyclic AMP rose after incubation with adrenaline (6 muM) plus phentolamine or adrenaline (15 muM) plus phentolamine plus caffeine (1 mM) but were similar in all four groups of women.	Epinephrine	53-63	latexin	Homo sapiens	67-70
168084-12	1975	Cell levels of cyclic AMP rose after incubation with adrenaline (6 muM) plus phentolamine or adrenaline (15 muM) plus phentolamine plus caffeine (1 mM) but were similar in all four groups of women.	Epinephrine	93-103	latexin	Homo sapiens	108-111
164909-7	1975	Epinephrine binding to liver plasma membranes was decreased by 79% by phospholipase A2 (phosphatide acylhydrolase EC 3.1.1.4), 81% by phospholipase C (phosphatidylcholine choline phosphohydrolase EC 3.1.4.3) and 59% by phospholipase D (phosphatidylcholine phosphatidohydrolase EC 3.1.4.4).	Epinephrine	0-11	phospholipase A2 group IB	Rattus norvegicus	70-86
164909-14	1975	GRP (10-5 M) was shown to inhibit epinephrine uptake rather than epinephrine release from the membrane.	Epinephrine	34-45	gastrin releasing peptide	Rattus norvegicus	0-11
1112448-0	1975	Plasma adrenaline and serum gastrin: studies in insulin-induced hypoglycemia and after adrenaline infusions.	Epinephrine	7-17	insulin	Homo sapiens	48-55
1112448-8	1975	It is concluded that adrenaline is a hitherto little recognized factor influencing the gastrin response to hypoglycemia.	Epinephrine	21-31	gastrin	Homo sapiens	87-94
1090438-10	1975	The potentiation of insulin release caused by two of the MAO inhibitors studied was abolished by addition of 1 muM epinephrine into the incubation medium.	Epinephrine	115-126	monoamine oxidase A	Rattus norvegicus	57-60
234978-2	1975	Intradermal injections of isoproterenol, 0.15 mg, or epinephrine, 0.3 mg, caused significant prompt increases in serum PTH levels.	Epinephrine	53-64	parathyroid hormone	Homo sapiens	119-122
1168515-0	1975	Effects of adrenaline, noradrenaline, isoprenaline and salbutamol on the production and release of renin by isolated renal cortical cells of the cat.	Epinephrine	11-21	renin	Homo sapiens	99-104
124056-2	1975	Strophanthine K, an inhibitor of (Na-+--K-+) -activated ATP-ase, prevented the activating effect of adrenaline on sodium transport, and in the medium with a low concentration of this ion--it only partially inhibited its actibating effect.	Epinephrine	100-110	dynein axonemal heavy chain 8	Homo sapiens	56-63
1090694-7	1975	Adrenaline (1 mumol/1) and diazoxide (250 mug/ml) abolished or attenuated the stimulation of insulin release by glucose, leucine plus arginine or theophylline from 24-day foetal, 1 day and 6 weeks postnatal pancreas.	Epinephrine	0-10	insulin	Oryctolagus cuniculus	93-100
1090694-8	1975	The stimulation of insulin release from 6-week-old pancreas by 1mM-barium was blocked by adrenaline and diazoxide but the effect became less with increasing immaturity.	Epinephrine	89-99	insulin	Oryctolagus cuniculus	19-26
165670-10	1975	Incubation of adipose tissue with high epinephrine concentrations (11 muM) increases the cAMP level, the protein kinase activity ratio, and glycerol production.	Epinephrine	39-50	cathelicidin antimicrobial peptide	Rattus norvegicus	89-93
173252-6	1975	It was confirmed that pigs react very rapidly (after 8 hours) to injection of corticotrophin, prednisolone or adrenaline with an increase in plasma haptoglobin.	Epinephrine	110-120	haptoglobin	Sus scrofa	148-159
1168515-4	1975	2 Noradrenaline (1.18 times 10-minus 4M) and adrenaline (1.09 times 10-minus 4M) added to the incubation medium stimulated renin production by 45 and 34% respectively, compared with the incubated controls.	Epinephrine	5-15	renin	Homo sapiens	123-128
1231964-2	1975	The response of platelet-rich plasma to 0.1, 1 and 10 muM of ADP and 1 and 10 muM of epinephrine were tested in a Chrono-Log aggregometer.	Epinephrine	85-96	latexin	Homo sapiens	78-81
1225939-3	1975	Epinephrine (10 muM) stimulated adenylate cyclase activity and this effect was slightly enhanced by phentolamine.	Epinephrine	0-11	latexin	Homo sapiens	16-19
127351-8	1975	This protein, which we have tentatively named phospholamban (lambda alpha mu beta alpha psi usilon epsilon omega = to receive) appears to particiapte in the regulation of calcium transport by the heart"s SR and may play a role in the inotropic actions of drugs, such as epinephrine, which act upon the cyclic AMP-PK system.	Epinephrine	270-281	phospholamban	Bos taurus	46-59
179104-6	1975	It was shown that adrenaline-induced lipolysis in the fat globules was not due to activation of lipase but to initiation of a reaction between lipase and triglyceride.	Epinephrine	18-28	lipase G, endothelial type	Rattus norvegicus	96-102
179104-6	1975	It was shown that adrenaline-induced lipolysis in the fat globules was not due to activation of lipase but to initiation of a reaction between lipase and triglyceride.	Epinephrine	18-28	lipase G, endothelial type	Rattus norvegicus	143-149
1197747-0	1975	The effect of epinephrine on liver 5-nucleotidase.	Epinephrine	14-25	5'-nucleotidase ecto	Homo sapiens	35-49
171710-2	1975	It has also been observed that phosphorylation of seryl residues of protein in sarcolemma- and sarcotubule-rich myocardial subcellular fractions by cyclic AMP activated intrinsic and extrinsic protein kinases confers upon these membran structures an enhanced ability to bind or take up Ca2+ and that dibutyryl cyclic AMP, like adrenaline, produces in intact cardiac muscle simultaneous increases in contractile force and in the uptake of extracellular Ca2+.	Epinephrine	327-337	adenine phosphoribosyltransferase	Homo sapiens	155-158
813283-1	1975	The effect of catecholamines, represented by epinephrine and norepinephrine, on the activity of phospholipase A2 from bee venom was studied.	Epinephrine	45-56	phospholipase A2 group IB	Homo sapiens	96-112
4611749-0	1974	Somatostatin inhibition of epinephrine-induced glucagon secretion.	Epinephrine	27-38	somatostatin	Homo sapiens	0-12
1119113-1	1975	An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen.	Epinephrine	50-60	fibrinogen beta chain	Homo sapiens	139-149
1119113-1	1975	An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen.	Epinephrine	50-60	fibrinogen beta chain	Homo sapiens	352-362
1119113-1	1975	An effect of increase in fibrinolytic activity of adrenaline-heparin (ADH) complex was studied under its incubation in a mixture with pure fibrinogen on unstablized plates of fibrin in presence of xi-aminocapronic acid, By means of spectrophotometry in UV-light an increase in lytic activity of the incubated mixture of adrenaline-heparin complex with fibrinogen was shown to be due to formation of a secondary complex, which included adrenaline, heparin and fibrinogen.	Epinephrine	50-60	fibrinogen beta chain	Homo sapiens	352-362
1119113-2	1975	After intravenous administration of a mixture of ADH complex with fibrinogen, containing products of interaction of adrenaline, heparin and fibrinogen, not only an increase in non-enzymic fibrinolytic activity of plasma occurred, but also an increase in duration of an effect of adrenaline--heparin--fibrinogen complex was observed in vivo as compared with the equivalent dose of the ADH complex	Epinephrine	116-126	fibrinogen beta chain	Homo sapiens	66-76
4364334-7	1974	During contact of neutrophils with RA serum-treated zymosan particles epinephrine, isoproterenol, and cyclic AMP inhibited both particle ingestion and beta-glucuronidase discharge.	Epinephrine	70-81	glucuronidase beta	Homo sapiens	151-169
4375185-28	1974	When adrenaline was infused into the ewe ( approximately 0.26 mug/min.kg) maternal plasma renin increased.	Epinephrine	5-15	renin	Ovis aries	90-95
4375185-29	1974	Maternal infusion of adrenaline raised foetal plasma renin significantly more (P &lt; 0.05) than foetal infusion.8.	Epinephrine	21-31	renin	Ovis aries	53-58
4413165-0	1974	Effects of small intravenous doses of epinephrine on serum insulin, glucose tolerance and serum free fatty acids.	Epinephrine	38-49	insulin	Homo sapiens	59-66
4417825-0	1974	Comparative study of cumulative and non-cumulative dose-response curves for noradrenaline and adrenaline in the isolated rat vas deferens.	Epinephrine	79-89	arginine vasopressin	Rattus norvegicus	125-128
4445050-0	1974	The effect of the chronic L-adrenaline, D, L-metanephrine and L-thyroxine administration on the MAO activity in rat"s brain.	Epinephrine	26-38	monoamine oxidase A	Rattus norvegicus	96-99
4853047-0	1974	Lowering of kininogen in rat blood by adrenaline and its inhibition by sympatholytic agents, heparin and aspirin.	Epinephrine	38-48	kininogen 2-like 1	Rattus norvegicus	12-21
4151956-3	1974	Epinephrine reduced the release of beta-glucuronidase from neutrophils in the presence of zymosan during 2-30 min of incubation and elicited a concomitant elevation of adenosine 3":5"-monophosphate levels.	Epinephrine	0-11	glucuronidase beta	Homo sapiens	35-53
4591826-0	1974	Effects of prostaglandin E1 and of epinephrine on the dynamics of insulin release in vitro.	Epinephrine	35-46	insulin	Homo sapiens	66-73
4406545-0	1974	Effects of adrenaline on insulin-induced release of growth hormone and cortisol in man.	Epinephrine	11-21	insulin	Homo sapiens	25-32
4406545-0	1974	Effects of adrenaline on insulin-induced release of growth hormone and cortisol in man.	Epinephrine	11-21	growth hormone 1	Homo sapiens	52-66
4277463-0	1974	Effect of COMT-inhibition on the renal excretion of (plus or minus)-adrenaline in dogs.	Epinephrine	68-78	catechol-O-methyltransferase	Canis lupus familiaris	10-14
4729041-0	1973	Acute parathyroid hormone response to epinephrine in vivo.	Epinephrine	38-49	parathyroid hormone	Bos taurus	6-25
4282116-0	1974	Consumption of kininogen, formation of kinin and activation of arginine ester hydrolase in rat peritoneal fluid cells in the presence of l-adrenaline.	Epinephrine	137-149	kininogen 2-like 1	Rattus norvegicus	15-24
4729041-11	1973	This points towards a common mechanism of the regulation of parathyroid hormone secretion caused by decreases in the extracellular calcium concentration and/or alterations in the distribution of calcium within parathyroid cells following the administration of epinephrine.	Epinephrine	260-271	parathyroid hormone	Bos taurus	60-79
4766218-4	1973	Elastin binds the (-)-isomer of adrenaline and noradrenaline to twice the extent of the (+)-isomer.3.	Epinephrine	32-42	elastin	Rattus norvegicus	0-7
4727451-5	1973	Release of insulin was strongly inhibited after epinephrine and norepinephrine, and strongly stimulated after isoproterenol.	Epinephrine	48-59	insulin	Canis lupus familiaris	11-18
4727451-7	1973	Secretion of insulin remained unchanged after epinephrine and norepinephrine, but was stimulated by isoproterenol.	Epinephrine	46-57	insulin	Canis lupus familiaris	13-20
4720024-0	1973	Release of gastrin by epinephrine in man.	Epinephrine	22-33	gastrin	Homo sapiens	11-18
4349947-10	1973	Combinations of 1 muM hydrocortisone and 1 muM epinephrine were sometimes additive or synergistic but in many instances higher glucocorticoid concentrations were needed to obtain augmentation of the catecholamine response.	Epinephrine	47-58	latexin	Homo sapiens	43-46
4700595-2	1973	The enzyme activity measured in the presence of stimulating hormones (epinephrine, prostaglandin PGE(1), parathyroid hormone) is also inhibited in these preparations by somatomedin.	Epinephrine	70-81	insulin-like growth factor 1	Rattus norvegicus	169-180
4768802-0	1973	[pH-Ca2 interaction in the effect of adrenaline on the force developed by the rat atrium].	Epinephrine	37-47	carbonic anhydrase 2	Rattus norvegicus	4-7
4780710-0	1973	[Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo].	Epinephrine	80-90	fibrinogen beta chain	Homo sapiens	16-26
4345738-0	1973	Reinforcement of reflex epinephrine release by angiotensin II.	Epinephrine	24-35	angiotensinogen	Homo sapiens	47-61
4780710-0	1973	[Formation of a fibrinogen-heparin complex in the presence of interaction of an adrenaline-heparin complex with fibrinogen in vitro and in vivo].	Epinephrine	80-90	fibrinogen beta chain	Homo sapiens	112-122
4348882-0	1973	[The effect of lysozyme, ribonuclease and cytochrome C on the activation of one of the blood coagulation factors--the Hageman factor--by adrenaline].	Epinephrine	137-147	lysozyme	Homo sapiens	15-23
5075509-4	1972	Under the incubation conditions used with glucose in the medium, the antilipolytic effect of insulin on the basal as well as on the adrenaline- and isopropylnoradrenaline-stimulated lipolysis was not consistent at any cell size studied.	Epinephrine	132-142	insulin	Homo sapiens	93-100
4348882-0	1973	[The effect of lysozyme, ribonuclease and cytochrome C on the activation of one of the blood coagulation factors--the Hageman factor--by adrenaline].	Epinephrine	137-147	cytochrome c, somatic	Homo sapiens	42-54
4403383-5	1972	Plasma cyclic GMP rose in response to infusions of alpha-adrenergic agents, viz., epinephrine or norepinephrine infused together with the beta-blocking agent, propranolol.	Epinephrine	82-93	5'-nucleotidase, cytosolic II	Homo sapiens	14-17
4675006-23	1972	We conclude that ADP and adrenaline, like thrombin and collagen, cause extrusion of non-metabolic granula-located platelet adenine nucleotides.	Epinephrine	25-35	coagulation factor II, thrombin	Homo sapiens	42-50
4403307-1	1972	Activity of serotonin N-acetyltransferase (EC 2.3.1.5) in rat pineal organ is rapidly and markedly elevated in vivo after administration of beta-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA), norepinephrine, epinephrine, isoproterenol, monoamine oxidase inhibitors, or theophylline.	Epinephrine	190-201	aralkylamine N-acetyltransferase	Rattus norvegicus	12-41
4559947-10	1972	The effect of epinephrine and propranolol on acute insulin responses to secretin and glucose was also different.	Epinephrine	14-25	insulin	Homo sapiens	51-58
5016304-2	1972	Fat mobilization per cell in response to epinephrine was well above normal in young "fatties"; in older "fatties" the output per cell fell to near normal, but the much greater number of fat cells per rat indicated that the fat mobilizing capacity of the older "fatty" is well above normal.	Epinephrine	41-52	FAT atypical cadherin 1	Rattus norvegicus	0-3
4332823-1	1972	Insulin depresses both the activity of adenylate cyclase stimulated by glucagon, epinephrine, and sodium fluoride in liver cell membranes and the activity of adenylate cyclase stimulated by epinephrine and adrenocorticotropin in particulate preparations from homogenates of isolated fat cells.	Epinephrine	81-92	insulin	Homo sapiens	0-7
4332823-1	1972	Insulin depresses both the activity of adenylate cyclase stimulated by glucagon, epinephrine, and sodium fluoride in liver cell membranes and the activity of adenylate cyclase stimulated by epinephrine and adrenocorticotropin in particulate preparations from homogenates of isolated fat cells.	Epinephrine	190-201	insulin	Homo sapiens	0-7
5016304-2	1972	Fat mobilization per cell in response to epinephrine was well above normal in young "fatties"; in older "fatties" the output per cell fell to near normal, but the much greater number of fat cells per rat indicated that the fat mobilizing capacity of the older "fatty" is well above normal.	Epinephrine	41-52	FAT atypical cadherin 1	Rattus norvegicus	85-88
4648583-0	1972	Epinephrine and norepinephrine excretion during running training at sea level and altitude.	Epinephrine	0-11	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	68-71
4651152-0	1972	Effects of exogenous epinephrine on glucose and insulin levels in infants of diabetic mothers.	Epinephrine	21-32	insulin	Homo sapiens	48-55
5158898-10	1971	The effect of insulin on pyruvate dehydrogenase activity was inhibited by adrenaline, adrenocorticotrophic hormone and dibutyryl cyclic AMP (6-N,2"-O-dibutyryladenosine 3":5"-cyclic monophosphate).	Epinephrine	74-84	insulin	Homo sapiens	14-21
4662476-0	1972	[Effect of adrenaline and adrenoxyl on the level of catecholamines and nonesterified fatty acids and lipase activity in rat tissues].	Epinephrine	11-21	lipase G, endothelial type	Rattus norvegicus	101-107
5152027-6	1971	Hypoglycaemia induced by insulin increased catecholamine secretion, with the adrenaline to noradrenaline ratio significantly higher than in the adrenal gland itself.6.	Epinephrine	77-87	insulin	Homo sapiens	25-32
4337656-0	1971	Antagonism between glucose and epinephrine regarding insulin secretion.	Epinephrine	31-42	insulin	Homo sapiens	53-60
5147437-0	1971	[Effects of epinephrine on insulin, glucagon and somatotropin in gastrectomized patients during glucose administration].	Epinephrine	12-23	growth hormone 1	Homo sapiens	49-61
4938132-0	1971	Epinephrine: selective inhibition of the acute insulin response to glucose.	Epinephrine	0-11	insulin	Homo sapiens	47-54
4938132-1	1971	An epinephrine infusion of 6 mug/min decreased the rapid insulin response to a 5 g glucose pulse by 96% (P &lt; 0.001) compared with the preinfusion control.	Epinephrine	3-14	insulin	Homo sapiens	57-64
4938132-2	1971	In contrast when an identical epinephrine infusion was superimposed on a prolonged glucose infusion, elevated steady-state insulin levels did not decrease, but increased from 26.9 +/-6 (mean +/-SD, muU/ml) to 56.8 +/-15 muU/ml (P &lt; 0.05) in parallel with the epinephrine-induced hyperglycemia.	Epinephrine	30-41	insulin	Homo sapiens	123-130
4938132-6	1971	Thus epinephrine appears to inhibit selectively the rapid insulin response to glucose but not to influence insulin output stimulated by prolonged hyperglycemia.	Epinephrine	5-16	insulin	Homo sapiens	58-65
4938132-3	1971	Thus epinephrine inhibition of insulin secretion was observed during acute but not chronic glucose stimulation.	Epinephrine	5-16	insulin	Homo sapiens	31-38
5284366-0	1971	Effect of adrenaline and glucose on release of glucagon and insulin in vitro.	Epinephrine	10-20	insulin	Homo sapiens	60-67
5548246-0	1971	In vitro binding study of epinephrine and bovine serum albumin.	Epinephrine	26-37	albumin	Homo sapiens	49-62
4330868-0	1971	Effects of cyclic AMP and epinephrine on insulin and growth hormone secretion in sheep.	Epinephrine	26-37	LOC105613195	Ovis aries	41-48
4330868-0	1971	Effects of cyclic AMP and epinephrine on insulin and growth hormone secretion in sheep.	Epinephrine	26-37	somatotropin	Ovis aries	53-67
4322665-12	1971	The activity was increased by NaF and by prostaglandin PGE(1) and was decreased by epinephrine.	Epinephrine	83-94	C-X-C motif chemokine ligand 8	Homo sapiens	30-33
5503940-0	1970	Demonstration of a plasmatic cofactor different from fibrinogen necessary for platelet release by ADP and adrenaline.	Epinephrine	106-116	fibrinogen beta chain	Homo sapiens	53-63
4394849-0	1970	The effect of alpha- and beta-adrenergic blocking agents on the renin response to hypoglycemia and epinephrine in dogs.	Epinephrine	99-110	renin	Canis lupus familiaris	64-69
5449180-3	1970	Serum albumin stimulates the uptake of U-glucose-(14)C and the incorporation of (14)C-counts into triglyceride glycerol and inhibits the incorporation of (14)C-counts into triglyceride fatty acids by isolated adipose cells; insulin and epinephrine enhance these effects.	Epinephrine	236-247	albumin	Homo sapiens	0-13
5503056-0	1970	Potentiation of lipogenic action of insulin by epinephrine observed in normal and maturity-onset diabetic individuals.	Epinephrine	47-58	insulin	Homo sapiens	36-43
5485150-15	1970	Thrombin caused the release from platelets of intact adrenaline but not of the metabolite.10.	Epinephrine	53-63	coagulation factor II, thrombin	Homo sapiens	0-8
5449180-7	1970	Increasing serum albumin concentrations do, however, stimulate the release of fatty acids and glycerol by epinephrine-treated cells increasingly until a plateau, determined by the epinephrine dose, is reached.	Epinephrine	106-117	albumin	Homo sapiens	11-24
5449180-7	1970	Increasing serum albumin concentrations do, however, stimulate the release of fatty acids and glycerol by epinephrine-treated cells increasingly until a plateau, determined by the epinephrine dose, is reached.	Epinephrine	180-191	albumin	Homo sapiens	11-24
5535405-0	1970	The effects of epinephrine, amino acids and albumin on the measurement of insulin by radioimmunoassay.	Epinephrine	15-26	insulin	Homo sapiens	74-81
5423322-0	1970	Insulin blockade of epinephrine.	Epinephrine	20-31	insulin	Homo sapiens	0-7
5491993-0	1970	The effect of adrenaline on calcitonin secretion in conscious sheep.	Epinephrine	14-24	calcitonin-like	Ovis aries	28-38
4238632-0	1969	[Action of dextrorotatory and levorotatory derivatives of N-isopropyl-paranitrophenylethanolamine (IPNEA) on C14-adrenaline distribution in rats in vivo].	Epinephrine	113-123	anti-Mullerian hormone receptor type 2	Rattus norvegicus	109-112
4312706-0	1970	The effect o angiotensin II on the platelet aggregation induced by adenosine diphosphate, epinephrine and thrombin.	Epinephrine	90-101	angiotensinogen	Homo sapiens	13-27
5807208-12	1969	(e) Adrenaline (1mum) abolished insulin release stimulated by glucose, leucine, tolbutamide, ouabain or Ba(2+).	Epinephrine	4-14	insulin	Oryctolagus cuniculus	32-39
4304350-0	1969	In vitro stimulation of renin production by epinephrine, norepinephrine, and cyclic AMP.	Epinephrine	44-55	renin	Homo sapiens	24-29
5773159-0	1969	Glycogen phosphorylase in the rat levator ani: activity related to testosterone, epinephrine and actinomycin D.	Epinephrine	81-92	glycogen phosphorylase L	Rattus norvegicus	0-22
4301369-0	1968	Impaired secretion of epinephrine in response to insulin among hypophysectomized dogs.	Epinephrine	22-33	insulin	Canis lupus familiaris	49-56
4244105-0	1969	[Effect of thyroid gland hormones and adrenaline on oxidative phosphorylation, ATPase activity and penetrability of mitochondrial membranes by sodium and potassium ions].	Epinephrine	38-48	dynein axonemal heavy chain 8	Homo sapiens	79-85
5649642-5	1968	Acid phosphatase, beta-glucuronidase and adenylate kinase were released to a small extent during second phase aggregation by ADP or adrenaline; thrombin and collagen particles caused significantly greater release of beta-glucuronidase than of either acid phosphatase or of adenylate kinase.4.	Epinephrine	132-142	glucuronidase beta	Homo sapiens	18-36
4302798-0	1968	[Effect of ACTH on the urinary excretion of adrenaline].	Epinephrine	44-54	proopiomelanocortin	Homo sapiens	11-15
4297415-8	1968	The slight increase in adrenaline output which followed the injection of bradykinin was dependent on the dose but the slope of the curve (b = 0.161) was much less than that for acetylcholine (b = 0.636).	Epinephrine	23-33	kininogen 1	Bos taurus	73-83
4298279-0	1968	[On the participation of the hypophyseal adrenocorticotropic hormone in adrenaline secretion by the adrenal glands].	Epinephrine	72-82	proopiomelanocortin	Homo sapiens	41-68
5649642-5	1968	Acid phosphatase, beta-glucuronidase and adenylate kinase were released to a small extent during second phase aggregation by ADP or adrenaline; thrombin and collagen particles caused significantly greater release of beta-glucuronidase than of either acid phosphatase or of adenylate kinase.4.	Epinephrine	132-142	coagulation factor II, thrombin	Homo sapiens	144-152
6049752-0	1967	Effect of epinephrine on insulin release in man induced by secretin.	Epinephrine	10-21	insulin	Homo sapiens	25-32
4383132-6	1967	The epinephrine-stabilizing effect of bovine serum albumin (Cohn-fraction V) was observed.	Epinephrine	4-15	albumin	Mus musculus	45-58
6021207-2	1967	Despite concurrent increases in arterial blood pressure, the plasma renin activity of normal subjects increased both in response to the infusion of catecholamines (norepinephrine: epinephrine, 10:1) and in response to stimulation of the sympathetic nervous system by cold.	Epinephrine	167-178	renin	Homo sapiens	68-73
6022061-0	1967	Epinephrine antagonism of insulin-dependent glucose uptake in the toad bladder.	Epinephrine	0-11	insulin	Homo sapiens	26-33
6020543-0	1967	Glucose metabolism and plasma insulin level during epinephrine infusion in the dog.	Epinephrine	51-62	insulin	Canis lupus familiaris	30-37
6018752-0	1967	A receptor mechanism for the inhibition of insulin release by epinephrine in man.	Epinephrine	62-73	insulin	Homo sapiens	43-50
6031349-0	1967	Ultrastructural analysis of adrenaline resynthesis following insulin treatment.	Epinephrine	28-38	insulin	Homo sapiens	61-68
6018752-2	1967	Epinephrine infusion was associated with low serum levels of immunoreactive insulin (IRI) except when phentolamine was given simultaneously.	Epinephrine	0-11	insulin	Homo sapiens	76-83
6018752-3	1967	These findings are compatible with an alpha receptor mechanism for the epinephrine inhibition of insulin release.	Epinephrine	71-82	insulin	Homo sapiens	97-104
5327562-0	1966	Lipolytic activity and inhibition of insulin release by epinephrine in the pig.	Epinephrine	56-67	insulin	Sus scrofa	37-44
4382032-4	1966	The rise in clotting factor VIII induced by adrenaline was blocked by pronethalol and propranalol but not by phentolamine.	Epinephrine	44-54	cytochrome c oxidase subunit 8A	Homo sapiens	28-32
5976694-0	1966	[Changes caused by adrenaline in blood catalase activity in relation to the administration of glucose in neurotics].	Epinephrine	19-29	catalase	Homo sapiens	39-47
5954696-0	1966	Detection and study of a cyclization step preceding the formation of a fluorescent product in tyrosinase-catalyzed adrenaline oxidation.	Epinephrine	115-125	tyrosinase	Homo sapiens	94-104
5891499-0	1965	On the antagonism of adrenaline by melanocyte stimulating hormone (MSH).	Epinephrine	21-31	proopiomelanocortin	Homo sapiens	35-65
5901508-0	1966	The effect of epinephrine on immunoreactive insulin levels in man.	Epinephrine	14-25	insulin	Homo sapiens	44-51
4955799-0	1966	Inhibition of insulin secretion by infused epinephrine in rhesus monkeys.	Epinephrine	43-54	insulin	Macaca mulatta	14-21
5891499-0	1965	On the antagonism of adrenaline by melanocyte stimulating hormone (MSH).	Epinephrine	21-31	proopiomelanocortin	Homo sapiens	67-70
4378505-0	1965	A relationship between adrenaline and the mode of action of oxytocin and oestrogen on vascular smooth muscle.	Epinephrine	23-33	oxytocin/neurophysin I prepropeptide	Homo sapiens	60-68
14253254-0	1964	[CONFIRMATION OF PREFERENTIAL HYDROLYSIS AT ALPHA, ALPHA" OF RESERVE TRIGLYCERIDES IN THE RAT UNDER ACTION OF TISSUE LIPASE STIMULATED BY EPINEPHRINE].	Epinephrine	138-149	lipase G, endothelial type	Rattus norvegicus	117-123
4157864-0	1965	[On the catalytic effect of epinephrine in methemoglobin reduction].	Epinephrine	28-39	hemoglobin subunit gamma 2	Homo sapiens	43-56
14170148-1	1964	RELEASE OF ADRENALINE BY BRADYKININ AND ANGIOTENSIN.	Epinephrine	11-21	kininogen 1	Homo sapiens	25-35
14190512-0	1964	[PRESUMPTIONS OF THE PREFERENTIAL HYDROLYSIS AT THE ALPHA AND ALPHA" POSITIONS OF RESERVE TRIGLYCERIDES IN RATS UNDER THE ACTION OF TISSUE LIPASE STIMULATED IN VITRO BY EPINEPHRINE].	Epinephrine	169-180	lipase G, endothelial type	Rattus norvegicus	139-145
14198303-0	1964	INSULIN-LIKE ACTIVITY IN PANCREATIC VEIN BLOOD AFTER GLUCOSE LOADING AND EPINEPHRINE HYPERGLYCEMIA.	Epinephrine	73-84	insulin	Homo sapiens	0-7
14219827-0	1964	[REINFORCING EFFECT OF ADRENALINE ON ANTIDIURESIS INDUCED BY VASOPRESSIN].	Epinephrine	23-33	arginine vasopressin	Homo sapiens	61-72
13963048-0	1963	[Effect of insulin on experimental acute pulmonary edema induced by adrenaline].	Epinephrine	68-78	insulin	Homo sapiens	11-18
14311457-0	1964	[EFFECT OF SYNTHETIC ANGIOTENSIN-II ON THE ARTERIAL PRESSURE OF DIFFERENT KINDS OF LABORATORY ANIMALS AND COMPARATIVE STUDY OF THIS ACTION WITH ADRENALINE AND NORADRENALINE].	Epinephrine	144-154	angiotensinogen	Homo sapiens	21-35
13949229-0	1963	Potentiation by adrenaline of a proteolytic activity associated with purified myosin.	Epinephrine	16-26	myosin heavy chain 14	Homo sapiens	78-84
13881449-0	1961	Effect of prior epinephrine upon adipose tissue sensitivity to insulin in vitro.	Epinephrine	16-27	insulin	Homo sapiens	63-70
13925529-0	1962	Epinephrine-induced release of ACTH in normal human subjects: a test of pituitary function.	Epinephrine	0-11	proopiomelanocortin	Homo sapiens	31-35
13706513-0	1961	Plasma epinephrine and norepinephrine levels during insulin-induced hypoglycemia in man.	Epinephrine	7-18	insulin	Homo sapiens	52-59
13785077-1	1961	HC1 on DOPA, dopamine, norepinephrine, epinephrine and serotonin levels in mouse brain.	Epinephrine	26-37	heterochromatin, Chr 1	Mus musculus	0-3
13720844-0	1961	Metabolism of adrenaline after blockade of monoamine oxidase and catechol-O-methyltransferase.	Epinephrine	14-24	catechol-O-methyltransferase	Felis catus	65-93
13707726-4	1961	In spinal atropinized rats injected with hexamethonium 5 mg/kg this pressor effect produced by injection of the adrenaline antagonist, compound AT3 [ethylfluoren-9-yl(2-iodoethyl)amine hydriodide], was reduced by prior treatment for five days with 1 mg/kg reserpine.	Epinephrine	112-122	angiotensin II receptor, type 1b	Rattus norvegicus	144-147
13806619-0	1960	Resynthesis of adrenaline in the rabbit"s adrenal medulla during insulin-induced hypoglycemia.	Epinephrine	15-25	insulin	Oryctolagus cuniculus	65-72
14442503-1	1960	Histidine decarboxylase activity of mouse tissues is increased by stress and by injection of epinephrine and norepinephrine, suggesting a balance between histamine and catechol amines producing a component of circulatory homeostasis.	Epinephrine	93-104	histidine decarboxylase	Mus musculus	0-23
13798429-3	1960	The responses of the nictitating membrane to adrenaline, noradrenaline and tyramine were potentiated by substance P as well.	Epinephrine	45-55	tachykinin precursor 1	Homo sapiens	104-115
13795313-1	1959	Pyrogallol inhibits the Omethylation of epinephrine and norepinephrine by catechol-O-methyl transferase in vitro as well as the metabolism of these catecholamines, and the formation of their O-methylated metabolites, in the intact mouse.	Epinephrine	40-51	catechol-O-methyltransferase	Mus musculus	74-103
13804541-1	1959	Failure to increase the epinephrine secretion in insulin-induced hypoglycemia.	Epinephrine	24-35	insulin	Homo sapiens	49-56
13795313-2	1959	Since pyrogallol also prolongs the physiological effects of epinephrine, it is suggested that catechol-O-methyl transferase terminates the actions of the catecholamine hormones.	Epinephrine	60-71	catechol-O-methyltransferase	Mus musculus	94-123
13580222-2	1958	The extent of the conLversion to metanephrine, a physiologically inactive compound, indicates that the enzyme responsible for this reaction, catechol-O-methyl transferase, is the enzyme mainly involved in the termination of action of epinephrine in man.	Epinephrine	234-245	catechol-O-methyltransferase	Homo sapiens	141-170
13371979-0	1956	Studies of the role of ceruloplasmin and albumin in adrenaline metabolism.	Epinephrine	52-62	ceruloplasmin	Homo sapiens	23-36
13331500-0	1956	[Study on the behavior of epinephrine and vitamin C in the adrenal cortex after administration of insulin, using a sample colorimetric determination method].	Epinephrine	26-37	insulin	Homo sapiens	98-105
13332051-0	1956	Excretion of epinephrine and norepinephrine after administration of insulin and methacholine.	Epinephrine	13-24	insulin	Homo sapiens	68-75
13107630-0	1953	Selective depletion of the adrenaline content of the suprarenal gland by the injection of insulin in the cat.	Epinephrine	27-37	insulin	Homo sapiens	90-97
13148332-0	1954	Immediate sensitization of isolated swine arteries and their vasa vasorum to epinephrine, acetylcholine and histamine by thyroxine.	Epinephrine	77-88	DEAD-box helicase 4	Sus scrofa	61-65
13036556-0	1953	The use of controlled hypotension combined with the local use of adrenaline as an aid to the fenestration operation.	Epinephrine	65-75	activation induced cytidine deaminase	Homo sapiens	82-85
13030793-0	1953	Effect of tyrosinase upon the fluorimetric determination of epinephrine and arterenol.	Epinephrine	60-71	tyrosinase	Homo sapiens	10-20
12997259-0	1952	Effects of thyrotoxic materials and vitamin B12 on the epinephrine content of adrenals.	Epinephrine	55-66	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	44-47
13030747-0	1953	Effects of ACTH, cortisone, desoxycorticosterone and epinephrine on the plasma hypertensinogen and renin concentration of dogs.	Epinephrine	53-64	renin	Canis lupus familiaris	99-104
14869513-2	1951	Plasma and serum prothrombin before and after intramuscular injection of adrenaline].	Epinephrine	73-83	coagulation factor II, thrombin	Homo sapiens	17-28
14861793-0	1951	The role of hypoglycaemia and of adrenaline in the response of the adrenal cortex to insulin.	Epinephrine	33-43	insulin	Homo sapiens	85-92
14816395-0	1951	Influence of adrenaline and insulin on adrenal cortical response to ACTH.	Epinephrine	13-23	proopiomelanocortin	Homo sapiens	68-72
14802472-0	1950	[Abnormal profile of the histaminemic curve of intravenous adrenaline load (Staub test) in subjects prepared with high doses of folliculin].	Epinephrine	59-69	folliculin	Homo sapiens	128-138
14777865-0	1950	Adrenaline and noradrenaline in the suprarenal medulla after insulin.	Epinephrine	0-10	insulin	Homo sapiens	61-68
18884303-0	1948	Inhibition of cholinesterase by adrenaline.	Epinephrine	32-42	butyrylcholinesterase	Homo sapiens	14-28
34003837-12	2021	It was concluded that Epi activates the beta-adrenergic receptors in C2C12 myotubes and the IL-6-STAT3 pathway, leading to the augmentation of LPS-induced activation of the NF-kappaB- C/EBPdelta-Atrogin-1 pathway and to the exacerbation of myotube wasting.	Epinephrine	22-25	signal transducer and activator of transcription 3	Homo sapiens	97-102
33751565-6	2021	In vitro, the treatments of MDSCs with epinephrine (EPI) and norepinephrine (NE) but not corticosterone (CORT) treated H22 conditioned medium obviously inhibited T cell proliferation, as well as enhanced CXCR2 expression and Erk phosphorylation.	Epinephrine	39-50	chemokine (C-X-C motif) receptor 2	Mus musculus	204-209
33751565-6	2021	In vitro, the treatments of MDSCs with epinephrine (EPI) and norepinephrine (NE) but not corticosterone (CORT) treated H22 conditioned medium obviously inhibited T cell proliferation, as well as enhanced CXCR2 expression and Erk phosphorylation.	Epinephrine	39-50	mitogen-activated protein kinase 1	Mus musculus	225-228
33851554-5	2021	Further substantiating this observation, we show in mouse aortic rings that insulin exposure suppresses epinephrine and norepinephrine-induced vasoconstriction.	Epinephrine	104-115	insulin	Homo sapiens	76-83
1244091-2	1975	MAO reaction inhibited by quinoline compound and the inhibition of kynurenine aminotransferase activity through the injection of epinephrine or serotonin were observed.	Epinephrine	129-140	monoamine oxidase A	Rattus norvegicus	0-3
33872989-4	2021	This effect is mediated by adrenaline stimulation of beta-2 adrenergic receptor (ADRB2), which activates the Hippo transducer, YAP/TAZ.	Epinephrine	27-37	adrenoceptor beta 2	Homo sapiens	53-79
33872989-4	2021	This effect is mediated by adrenaline stimulation of beta-2 adrenergic receptor (ADRB2), which activates the Hippo transducer, YAP/TAZ.	Epinephrine	27-37	adrenoceptor beta 2	Homo sapiens	81-86
33872989-4	2021	This effect is mediated by adrenaline stimulation of beta-2 adrenergic receptor (ADRB2), which activates the Hippo transducer, YAP/TAZ.	Epinephrine	27-37	Yes1 associated transcriptional regulator	Homo sapiens	127-130
33872989-4	2021	This effect is mediated by adrenaline stimulation of beta-2 adrenergic receptor (ADRB2), which activates the Hippo transducer, YAP/TAZ.	Epinephrine	27-37	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	131-134
33872989-5	2021	Inhibition and RNAi experiments revealed that inhibition of ADRB2 attenuated the adrenaline-triggered activity of YAP/TAZ and subsequently attenuated MPNST cells stemness.	Epinephrine	81-91	adrenoceptor beta 2	Homo sapiens	60-65
33872989-5	2021	Inhibition and RNAi experiments revealed that inhibition of ADRB2 attenuated the adrenaline-triggered activity of YAP/TAZ and subsequently attenuated MPNST cells stemness.	Epinephrine	81-91	Yes1 associated transcriptional regulator	Homo sapiens	114-117
33872989-5	2021	Inhibition and RNAi experiments revealed that inhibition of ADRB2 attenuated the adrenaline-triggered activity of YAP/TAZ and subsequently attenuated MPNST cells stemness.	Epinephrine	81-91	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	118-121
33847279-0	2021	GPER mediates estrogen cardioprotection against epinephrine-induced stress.	Epinephrine	48-59	G protein-coupled estrogen receptor 1	Rattus norvegicus	0-4
33847279-3	2021	In this study, we investigated the effects and mechanism of GPER on epinephrine (Epi)-induced cardiac stress.	Epinephrine	68-79	G protein-coupled estrogen receptor 1	Rattus norvegicus	60-64
33847279-3	2021	In this study, we investigated the effects and mechanism of GPER on epinephrine (Epi)-induced cardiac stress.	Epinephrine	81-84	G protein-coupled estrogen receptor 1	Rattus norvegicus	60-64
34003837-12	2021	It was concluded that Epi activates the beta-adrenergic receptors in C2C12 myotubes and the IL-6-STAT3 pathway, leading to the augmentation of LPS-induced activation of the NF-kappaB- C/EBPdelta-Atrogin-1 pathway and to the exacerbation of myotube wasting.	Epinephrine	22-25	nuclear factor kappa B subunit 1	Homo sapiens	173-182
34003837-12	2021	It was concluded that Epi activates the beta-adrenergic receptors in C2C12 myotubes and the IL-6-STAT3 pathway, leading to the augmentation of LPS-induced activation of the NF-kappaB- C/EBPdelta-Atrogin-1 pathway and to the exacerbation of myotube wasting.	Epinephrine	22-25	CCAAT enhancer binding protein delta	Homo sapiens	184-194
34003837-12	2021	It was concluded that Epi activates the beta-adrenergic receptors in C2C12 myotubes and the IL-6-STAT3 pathway, leading to the augmentation of LPS-induced activation of the NF-kappaB- C/EBPdelta-Atrogin-1 pathway and to the exacerbation of myotube wasting.	Epinephrine	22-25	F-box protein 32	Homo sapiens	195-204
33964196-5	2021	The minimal effective concentration of adrenaline was found to be 2 mug mL-1 for postoperative analgesia.	Epinephrine	39-49	L1 cell adhesion molecule	Mus musculus	72-76
34025450-11	2021	Adrenaline-collagen synergism, expressed as PS exposure, was significantly reduced by cyclooxygenase inhibitor (acetylsalicic acid), GPIIb/IIIa receptor blocker (tirofiban), and P2Y12 receptor antagonist (PSB 0739).	Epinephrine	0-10	integrin subunit alpha 2b	Homo sapiens	133-138
33904806-1	2021	OBJECTIVE: To determine the in vitro effects of epinephrine, norepinephrine, and dobutamine on lipopolysaccharide (LPS)-stimulated production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) in blood from healthy dogs.	Epinephrine	48-59	tumor necrosis factor	Canis lupus familiaris	145-172
33879760-0	2021	Epinephrine Auto-Injection After Allergic Reaction Leading to Gas Gangrene of the Leg.	Epinephrine	0-11	gastrin	Homo sapiens	62-65
33093660-2	2021	While the hormone epinephrine binds beta1AR and beta2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the beta1AR.	Epinephrine	18-29	adrenoceptor beta 1	Homo sapiens	36-43
33093660-2	2021	While the hormone epinephrine binds beta1AR and beta2AR with similar affinity, the smaller neurotransmitter norepinephrine is approximately tenfold selective for the beta1AR.	Epinephrine	18-29	adenosine A2a receptor	Homo sapiens	48-55
33843213-4	2021	SPILLO-PBSS software suggests an additional inhibitory activity of finasteride on phenylethanolamine N-methyltransferase (PNMT), the limiting enzyme in formation of the stress hormone epinephrine.	Epinephrine	184-195	phenylethanolamine-N-methyltransferase	Rattus norvegicus	82-120
33843213-4	2021	SPILLO-PBSS software suggests an additional inhibitory activity of finasteride on phenylethanolamine N-methyltransferase (PNMT), the limiting enzyme in formation of the stress hormone epinephrine.	Epinephrine	184-195	phenylethanolamine-N-methyltransferase	Rattus norvegicus	122-126
33904806-8	2021	RESULTS: Incubation of blood with epinephrine and norepinephrine significantly increased LPS-stimulated production of IL-10, compared with the control.	Epinephrine	34-45	interleukin 10	Canis lupus familiaris	118-123
33904806-9	2021	Epinephrine and norepinephrine significantly decreased LPS-stimulated production of TNF-alpha, compared with the control.	Epinephrine	0-11	tumor necrosis factor	Canis lupus familiaris	84-93
33904806-12	2021	CONCLUSIONS AND CLINICAL RELEVANCE: Epinephrine and norepinephrine, but not dobutamine, had immunomodulatory effects on LPS-stimulated TNF-alpha and IL-10 production in blood from healthy dogs in this in vitro model of sepsis.	Epinephrine	36-47	tumor necrosis factor	Canis lupus familiaris	135-144
33904806-12	2021	CONCLUSIONS AND CLINICAL RELEVANCE: Epinephrine and norepinephrine, but not dobutamine, had immunomodulatory effects on LPS-stimulated TNF-alpha and IL-10 production in blood from healthy dogs in this in vitro model of sepsis.	Epinephrine	36-47	interleukin 10	Canis lupus familiaris	149-154
33093660-3	2021	To understand the structural basis for this physiologically important selectivity, we solved the crystal structures of the human beta1AR bound to an antagonist carazolol and different agonists including norepinephrine, epinephrine and BI-167107.	Epinephrine	206-217	adrenoceptor beta 1	Homo sapiens	129-136
31959019-0	2021	Long-term safety and efficacy studies of epinephrine HFA metered-dose inhaler (Primatene  Mist): a two-stage randomized controlled trial.	Epinephrine	41-52	cytokine dependent hematopoietic cell linker	Homo sapiens	90-94
33879760-3	2021	Epinephrine is the most commonly reported medication leading to gas gangrene.	Epinephrine	0-11	gastrin	Homo sapiens	64-67
33879760-10	2021	CONCLUSIONS With millions of epinephrine auto-injectors prescribed yearly in the United States, awareness of clostridial gas gangrene following epinephrine auto-injection for the provider may help guide decision-making in patients presenting with extreme pain, redness, or swelling near the injection site after epinephrine injection.	Epinephrine	144-155	gastrin	Homo sapiens	121-124
33879760-10	2021	CONCLUSIONS With millions of epinephrine auto-injectors prescribed yearly in the United States, awareness of clostridial gas gangrene following epinephrine auto-injection for the provider may help guide decision-making in patients presenting with extreme pain, redness, or swelling near the injection site after epinephrine injection.	Epinephrine	144-155	gastrin	Homo sapiens	121-124
33834342-8	2021	The lung tumor suppressor protein (p53) and B-cell lymphoma-2 (Bcl-2) mRNA expression significantly increased in the rats treated with ALE and AFE.	Epinephrine	135-138	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	35-38
33834342-8	2021	The lung tumor suppressor protein (p53) and B-cell lymphoma-2 (Bcl-2) mRNA expression significantly increased in the rats treated with ALE and AFE.	Epinephrine	135-138	BCL2, apoptosis regulator	Rattus norvegicus	62-68
33655750-3	2021	The structures of the gas-phase complexes were investigated by selective laser photodissociation of the diazirine chromophore at 354 nm, which resulted in a loss of N2 and formation of a transient carbene intermediate in the adrenaline ligand without causing its expulsion.	Epinephrine	225-235	gastrin	Homo sapiens	22-25
33655750-10	2021	A close match (337 A2) was found for a single low Gibbs energy structure that displayed a binding pocket with Ser 2 and Ser 5 residues forming hydrogen bonds to the adrenaline catechol hydroxyls.	Epinephrine	165-175	jagged canonical Notch ligand 2	Homo sapiens	110-115
33746717-7	2021	Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated.	Epinephrine	146-157	dopamine beta-hydroxylase	Rattus norvegicus	19-44
33629519-6	2021	Altogether, this led to an increase in intracellular lipid accumulation during preadipocyte differentiation, coupled with an increase in adrenaline-induced oxygen consumption mediated by neuropeptide B.	Epinephrine	137-147	neuropeptide B	Rattus norvegicus	187-201
33712718-1	2021	The neonatal resuscitation program recommends a wide dose range of epinephrine for newborns who receive chest compressions (endotracheal tube [ET] dose of 0.05-0.1 mg/kg or intravenous [IV] dose of 0.01-0.03 mg/kg), which presents a challenge to neonatal care providers when attempting to determine the optimal initial dose.	Epinephrine	67-78	major facilitator superfamily domain containing 11	Homo sapiens	143-145
33712718-3	2021	Based on animal data, we suggest preparing 0.1 mg/kg or 1 ml/kg of 1 mg/10 ml epinephrine in a 5 ml syringe for ET administration.	Epinephrine	78-89	major facilitator superfamily domain containing 11	Homo sapiens	112-114
33691777-1	2021	OBJECTIVE: Lymphocytes express tyrosine hydroxylase (TH), the rate-limiting enzyme for the synthesis of dopamine, norepinephrine and epinephrine.	Epinephrine	117-128	tyrosine hydroxylase	Mus musculus	31-51
33746717-7	2021	Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated.	Epinephrine	146-157	dopamine beta-hydroxylase	Rattus norvegicus	46-49
33746717-7	2021	Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated.	Epinephrine	146-157	phenylethanolamine-N-methyltransferase	Rattus norvegicus	55-93
33746717-7	2021	Immunolabeling for dopamine beta-hydroxylase (DBH) and phenylethanolamine N-methyltransferase (PNMT), enzymes responsible for the synthesis of norepinephrine (NE) and epinephrine (E), respectively, were evaluated.	Epinephrine	146-157	phenylethanolamine-N-methyltransferase	Rattus norvegicus	95-99
33481407-14	2021	We observed that epinephrine and norepinephrine induced actin cytoskeletal rearrangement and normalized the membrane expression of proteins involved with adherens-junctions (vascular endothelial-cadherin) and tight-junctions (zona occludens-1).	Epinephrine	17-28	cadherin 5	Homo sapiens	174-203
33684473-3	2021	Therefore, we performed a systematic review and meta-analysis of data from the literature to determine the association between CRP and post-procedure ALE in PAD patients.	Epinephrine	150-153	C-reactive protein	Homo sapiens	127-130
33684473-4	2021	METHODS: Studies investigating the association between CRP and post-procedure ALE (target vessel revascularization, amputation, restenosis, disease progression, and the composite endpoint of any of these adverse limb events) were identified in the Medline, EMBASE, and Cochrane databases.	Epinephrine	78-81	C-reactive protein	Homo sapiens	55-58
33481407-17	2021	Our studies suggest that both beta1- and beta2-adrenergic receptor mediate the stabilizing effects of epinephrine and norepinephrine on the endothelial barrier.	Epinephrine	102-113	adrenoceptor beta 1	Homo sapiens	30-66
33481407-14	2021	We observed that epinephrine and norepinephrine induced actin cytoskeletal rearrangement and normalized the membrane expression of proteins involved with adherens-junctions (vascular endothelial-cadherin) and tight-junctions (zona occludens-1).	Epinephrine	17-28	tight junction protein 1	Homo sapiens	226-242
33481407-16	2021	CONCLUSIONS: Our findings demonstrate that treatment with epinephrine or norepinephrine strongly reduces endothelial permeability induced by agonists of multiple Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro.	Epinephrine	58-69	toll like receptor 2	Homo sapiens	183-203
33481407-16	2021	CONCLUSIONS: Our findings demonstrate that treatment with epinephrine or norepinephrine strongly reduces endothelial permeability induced by agonists of multiple Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro.	Epinephrine	58-69	toll like receptor 3	Homo sapiens	205-225
33481407-16	2021	CONCLUSIONS: Our findings demonstrate that treatment with epinephrine or norepinephrine strongly reduces endothelial permeability induced by agonists of multiple Toll-like receptors (Toll-like receptor-2, Toll-like receptor-3, Toll-like receptor-4) in vitro.	Epinephrine	58-69	toll like receptor 4	Homo sapiens	227-247
33367607-5	2021	Repeated exposure to norepinephrine or salbutamol suppressed both the glucagon and epinephrine responses to hypoglycemia compared to controls.	Epinephrine	24-35	glucagon	Rattus norvegicus	70-78
33564118-6	2021	RESULTS: The adrenaline concentration following dopamine infusion was increased by 59 +- 7% in CSCI (p = 0.038, Cohen"s d effect size (ES): 1.47), while this was not changed in AB (p = 0.223).	Epinephrine	13-23	CSCI	Homo sapiens	95-99
33480457-0	2021	SCN5A-C683R exhibits combined gain-of-function and loss-of-function properties related to epinephrine-triggered ventricular arrhythmia.	Epinephrine	90-101	sodium voltage-gated channel alpha subunit 5	Homo sapiens	0-5
33480457-1	2021	NEW FINDINGS: SCN5A-C683R is a novel variant associated with an uncommon phenotype of epinephrine-triggered ventricular arrhythmia in the absence of a distinct ECG phenotype.	Epinephrine	86-97	sodium voltage-gated channel alpha subunit 5	Homo sapiens	14-19
33480457-7	2021	The index patients of both families experienced epinephrine-triggered ventricular arrhythmia with cardiac arrest but did not show a specific electrocardiographic phenotype, raising the hypothesis that SCN5A C683R might be a susceptibility variant and the genetic substrate of distinct inherited arrhythmia.	Epinephrine	48-59	sodium voltage-gated channel alpha subunit 5	Homo sapiens	201-206
33547770-12	2021	Epinephrine upregulated alpha1-AR expression in T cells derived from CIA mice.	Epinephrine	0-11	adenosine A1 receptor	Mus musculus	24-33
33379058-1	2021	A novel smartphone-assisted portable biosensor based on laccase-mineral hybrid microflowers (La-HMFs) was applied for real-time, accurate and reliable quantification of epinephrine (EP).	Epinephrine	169-180	epiregulin	Homo sapiens	182-184
33692790-4	2021	Our results show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells.	Epinephrine	90-101	phenylethanolamine-N-methyltransferase	Mus musculus	22-55
33692790-4	2021	Our results show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells.	Epinephrine	90-101	phenylethanolamine-N-methyltransferase	Mus musculus	57-61
33692790-7	2021	Epinephrine producing TH17 cells exhibit co-expression of GM-CSF, suggesting they are pathogenic TH17 cells.	Epinephrine	0-11	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	58-64
33639628-2	2021	The underlying mechanism in HAE is related to bradykinin dysregulation which causes these attacks not to respond to common treatment strategies including epinephrine/corticosteroid or adrenaline.	Epinephrine	154-165	kininogen 1	Homo sapiens	46-56
33639628-2	2021	The underlying mechanism in HAE is related to bradykinin dysregulation which causes these attacks not to respond to common treatment strategies including epinephrine/corticosteroid or adrenaline.	Epinephrine	184-194	kininogen 1	Homo sapiens	46-56
33547770-2	2021	Tyrosine hydroxylase (TH), a rate-limiting enzyme for synthesis of neuroendocrine hormones such as epinephrine, is also expressed in T lymphocytes and regulates balance between helper T (Th) 17 cells and regulatory T (Treg) cells.	Epinephrine	99-110	tyrosine hydroxylase	Mus musculus	0-20
33547770-3	2021	Herein, we aimed to show that TH expression in joints alleviates joint inflammation and Th17/Treg imbalance in collagen-induced arthritis (CIA), an animal model of RA, and these effects may be implemented by the mechanism of epinephrine action on alpha1-adrenoreceptor (alpha1-AR) in T cells.	Epinephrine	225-236	adenosine A1 receptor	Mus musculus	270-279
33547770-14	2021	CONCLUSION: Upregulating TH expression in joints alleviates joint inflammation and Th17/Treg imbalance in CIA at least partially by enhancing epinephrine action on alpha1-AR in T cells.	Epinephrine	142-153	adenosine A1 receptor	Mus musculus	164-173
33603669-5	2020	Meanwhile, IOP treatment increased in expression of the NLRP3 inflammasome, IL-1beta, and IL-18 in the colon of CAC mice.	Epinephrine	11-14	NLR family, pyrin domain containing 3	Mus musculus	56-61
33603669-5	2020	Meanwhile, IOP treatment increased in expression of the NLRP3 inflammasome, IL-1beta, and IL-18 in the colon of CAC mice.	Epinephrine	11-14	interleukin 1 alpha	Mus musculus	76-84
33603669-5	2020	Meanwhile, IOP treatment increased in expression of the NLRP3 inflammasome, IL-1beta, and IL-18 in the colon of CAC mice.	Epinephrine	11-14	interleukin 18	Mus musculus	90-95
33372534-4	2021	In vitro evidence showed a direct interaction in ADRB1 and GRK2 and genetic depletion of GRK2 blocks epinephrine-induced upregulation of hypertrophic and fibrotic genes in cardiomyocytes.	Epinephrine	101-112	adrenoceptor beta 1	Homo sapiens	49-54
33494360-4	2021	Mouse models of exercise have shown therapeutic efficacy across numerous cancer models, at least in part due to the secretion of adrenaline, which mobilizes cells of the immune system, i.e., cytotoxic T and natural killer (NK) cells, through signaling of the beta-2 adrenergic receptor (beta2AR).	Epinephrine	129-139	adrenergic receptor, beta 2	Mus musculus	259-285
33494360-4	2021	Mouse models of exercise have shown therapeutic efficacy across numerous cancer models, at least in part due to the secretion of adrenaline, which mobilizes cells of the immune system, i.e., cytotoxic T and natural killer (NK) cells, through signaling of the beta-2 adrenergic receptor (beta2AR).	Epinephrine	129-139	adenosine A2a receptor	Mus musculus	287-294
33483878-5	2022	Studies in different experimental animal species and in humans indicate that KOR agonists decrease antidiuretic hormone (ADH) secretion and release from the hypothalamus and posterior pituitary; decrease response to ADH in kidneys; increase renal sympathetic nerve activity; and increase adrenaline, noradrenaline, and dopamine release from the adrenal medulla.	Epinephrine	288-298	opioid receptor kappa 1	Homo sapiens	77-80
33395257-7	2021	Inspired by the unique luminescence characteristics of Tb-Ru-MOG, the application in electroanalytical chemistry was identified by the ECL on-off response for epinephrine with a linear range from 1.0 x 10-10 to 1.0 x 10-3 mol L-1 and a detection limit of 5.2 x 10-11 mol L-1.	Epinephrine	159-170	myelin oligodendrocyte glycoprotein	Homo sapiens	55-64
33372534-4	2021	In vitro evidence showed a direct interaction in ADRB1 and GRK2 and genetic depletion of GRK2 blocks epinephrine-induced upregulation of hypertrophic and fibrotic genes in cardiomyocytes.	Epinephrine	101-112	G protein-coupled receptor kinase 2	Homo sapiens	59-63
33372534-4	2021	In vitro evidence showed a direct interaction in ADRB1 and GRK2 and genetic depletion of GRK2 blocks epinephrine-induced upregulation of hypertrophic and fibrotic genes in cardiomyocytes.	Epinephrine	101-112	G protein-coupled receptor kinase 2	Homo sapiens	89-93
33372534-8	2021	Paroxetine treatment also blocks epinephrine-induced upregulation of hypertrophic and fibrotic genes as well as ADRB1 internalization in cardiomyocytes.	Epinephrine	33-44	adrenoceptor beta 1	Homo sapiens	112-117
33456713-6	2021	We further demonstrated the downregulation of the Phenylethanolamine N-Methyltransferase gene in NB biopsies and in NB-PDX explaining this biochemical phenotype, and giving a rational to the low levels of epinephrine and MN measured in NB affected patients.	Epinephrine	205-216	phenylethanolamine N-methyltransferase	Homo sapiens	50-88
33052459-0	2021	Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice.	Epinephrine	56-66	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	118-123
33457164-7	2021	The antiplatelet activity of serine protease was demonstrated by inhibition of agonists induced platelet aggregation; it was in the order of Epinephrine > Adenosine tri phosphate.	Epinephrine	141-152	coagulation factor II, thrombin	Homo sapiens	29-44
33052459-0	2021	Hypothalamic MC4R regulates glucose homeostasis through adrenaline-mediated control of glucose reabsorption via renal GLUT2 in mice.	Epinephrine	56-66	melanocortin 4 receptor	Mus musculus	13-17
33052459-7	2021	We also evaluated glucose homeostasis in adrenaline (epinephrine)-deficient mice to investigate the role of adrenaline in mediating the effects of MC4R in glucose homeostasis.	Epinephrine	108-118	melanocortin 4 receptor	Mus musculus	147-151
33052459-12	2021	The MC4R deficiency suppressed renal sympathetic nerve activity by 50% in addition to decreasing circulating adrenaline and renal GLUT2 levels in mice, which contributed to the elevated glucosuria.	Epinephrine	109-119	melanocortin 4 receptor	Mus musculus	4-8
33052459-13	2021	We further report that adrenaline-deficient mice recapitulated the increased excretion of glucose in urine observed in the MC4R-deficient mice.	Epinephrine	23-33	melanocortin 4 receptor	Mus musculus	123-127
33052459-14	2021	Restoration of circulating adrenaline in both the MC4R- and adrenaline-deficient mice reversed their phenotype of improved glucose tolerance and elevated glucosuria, demonstrating the role of adrenaline in mediating the effects of MC4R on glucose reabsorption.	Epinephrine	27-37	melanocortin 4 receptor	Mus musculus	50-54
33052459-14	2021	Restoration of circulating adrenaline in both the MC4R- and adrenaline-deficient mice reversed their phenotype of improved glucose tolerance and elevated glucosuria, demonstrating the role of adrenaline in mediating the effects of MC4R on glucose reabsorption.	Epinephrine	27-37	melanocortin 4 receptor	Mus musculus	231-235
33052459-14	2021	Restoration of circulating adrenaline in both the MC4R- and adrenaline-deficient mice reversed their phenotype of improved glucose tolerance and elevated glucosuria, demonstrating the role of adrenaline in mediating the effects of MC4R on glucose reabsorption.	Epinephrine	60-70	melanocortin 4 receptor	Mus musculus	231-235
33052459-14	2021	Restoration of circulating adrenaline in both the MC4R- and adrenaline-deficient mice reversed their phenotype of improved glucose tolerance and elevated glucosuria, demonstrating the role of adrenaline in mediating the effects of MC4R on glucose reabsorption.	Epinephrine	60-70	melanocortin 4 receptor	Mus musculus	231-235
33052459-15	2021	CONCLUSIONS/INTERPRETATION: These findings define a previously unrecognised function of hypothalamic MC4R in glucose reabsorption mediated by adrenaline and renal GLUT2.	Epinephrine	142-152	melanocortin 4 receptor	Mus musculus	101-105
33488751-6	2020	The antihypertensive effect of CAPE was established by measuring SBP, DBP, MAP, and HR in ethanol-sucrose- and epinephrine-induced hypertension.	Epinephrine	111-122	structural maintenance of chromosomes 2	Rattus norvegicus	31-35
33349836-7	2020	The results showed that the levels of epinephrine and CORT in the serum of the rats in CS group were significantly increased compared with those in the control group (P < 0.05).	Epinephrine	38-49	citrate synthase	Rattus norvegicus	87-89
33348552-9	2020	Adrenaline promoted protein-protein interactions between sortin nexin-9 and neural Wiskott-Aldrich syndrome protein (a regulator of actin polymerization).	Epinephrine	0-10	WASP like actin nucleation promoting factor	Homo sapiens	76-115
33384769-11	2020	Adipocytes from mice lacking beta1-, beta2- and beta3-ARs (triple KO) also responded to millimolar doses of adrenaline or noradrenaline by activating hexose transport in the presence of 100 micromol/L vanadate.	Epinephrine	108-118	brain protein 1	Mus musculus	29-53
33317157-1	2020	In this study, the use of weighted linear regression in the development of electrochemical methods for the determination of epinephrine (EP), ascorbic acid (AA), and uric acid (UA) is presented.	Epinephrine	124-135	epiregulin	Homo sapiens	137-139
32948909-8	2020	Pharmacologic strategies include abrogating the beta2-adrenergic receptor signaling pathway to antagonize epinephrine and norepinephrine action on tumor and immune cells.	Epinephrine	106-117	adrenoceptor beta 2	Homo sapiens	48-73
32429680-13	2020	Although EA and pharmacological treatment did not differ in terms of pain relief, in vitro epinephrine and norepinephrine reduced TNF-alpha production in response to LPS stimuli.	Epinephrine	91-102	tumor necrosis factor	Homo sapiens	130-139
32918113-2	2020	Epinephrine released during stress acts via beta 2-adrenergic receptors (beta2-AR or ADRB2) to stimulate the synthesis of cyclic adenosine monophosphate (cAMP) in the red blood cells (RBCs).	Epinephrine	0-11	adenosine A2a receptor	Homo sapiens	73-81
32918113-2	2020	Epinephrine released during stress acts via beta 2-adrenergic receptors (beta2-AR or ADRB2) to stimulate the synthesis of cyclic adenosine monophosphate (cAMP) in the red blood cells (RBCs).	Epinephrine	0-11	adrenoceptor beta 2	Homo sapiens	85-90
32918113-12	2020	Polymorphism in codon 16 (rs1042713) of the beta2-AR gene influences cAMP concentrations in the RBC both before and after epinephrine treatment.	Epinephrine	122-133	adenosine A2a receptor	Homo sapiens	44-52
32928910-3	2020	Here we show that activation of ADRB2 by epinephrine, increased in response to immobilization stress, delays the loss of MCL1 apoptosis regulator (MCL1) protein expression induced by cytotoxic drugs in prostate cancer cells; and thus, increases resistance of prostate cancer xenografts to cytotoxic therapies.	Epinephrine	41-52	adrenoceptor beta 2	Homo sapiens	32-37
33324347-6	2020	Furthermore, excess of epinephrine could affect glucose intolerance mainly by impaired insulin secretion and excess of norepinephrine could affect glucose intolerance mainly by increased insulin resistance.	Epinephrine	23-34	insulin	Homo sapiens	87-94
32590700-11	2020	Epinephrine and phenylephrine groups significantly reduced trachea wet-to-dry weight ratio and lung vascular endothelial growth factor-A level compared to control group.	Epinephrine	0-11	vascular endothelial growth factor A	Ovis aries	100-136
33244644-4	2020	It was found that there are no indication on formation on hydrogen bonding between the two catecholic OHs where the one formed between the amino group and the hydroxyl oxygen atom of adrenaline monomer was broken in AS1 to form two new interactions namely SH...N and O1H1...S, while it retained in other complexes.	Epinephrine	183-193	prostaglandin D2 receptor	Homo sapiens	216-219
33324347-7	2020	Glucose intolerance on paraganglioma could be caused by increased insulin resistance mainly considering paraganglioma produces more norepinephrine than epinephrine.	Epinephrine	135-146	insulin	Homo sapiens	66-73
33208818-3	2020	The alpha-1-adrenergic receptors (alpha1-AR) facilitate Epinephrine (Epi)-mediated AMPK activation, linking metabolism and kidney function.	Epinephrine	56-67	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	83-87
33147410-1	2020	The enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephrine and is a potential drug target, primarily for the control of hypertension.	Epinephrine	118-129	phenylethanolamine N-methyltransferase	Homo sapiens	11-49
33147410-1	2020	The enzyme phenylethanolamine N-methyltransferase (PNMT, EC 2.1.1.28) catalyzes the final step in the biosynthesis of epinephrine and is a potential drug target, primarily for the control of hypertension.	Epinephrine	118-129	phenylethanolamine N-methyltransferase	Homo sapiens	51-55
33208818-3	2020	The alpha-1-adrenergic receptors (alpha1-AR) facilitate Epinephrine (Epi)-mediated AMPK activation, linking metabolism and kidney function.	Epinephrine	56-59	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	83-87
33312799-0	2020	Second Dose of Epinephrine for Anaphylaxis in the First Aid Setting: A Scoping Review.	Epinephrine	15-26	activation induced cytidine deaminase	Homo sapiens	56-59
33227660-3	2020	Insulin-induced hypoglycemia elicited a significant dynamic response of IL-6, adrenaline, noradrenaline, GH, prolactin, ACTH and serum and salivary cortisol (P < 0.001 for all variables).	Epinephrine	78-88	insulin	Homo sapiens	0-7
33437747-2	2020	Epinephrine and norepinephrine are stress hormones which affect many cells, including immune cells through interaction with adrenergic receptors, mainly beta2-adrenergic receptor.	Epinephrine	0-11	adrenoceptor beta 2	Homo sapiens	153-178
33312799-1	2020	Anaphylaxis is a life-threatening hypersensitivity reaction where rapid, early administration of epinephrine (adrenaline) can be lifesaving in the first aid setting.	Epinephrine	97-108	activation induced cytidine deaminase	Homo sapiens	153-156
33312799-1	2020	Anaphylaxis is a life-threatening hypersensitivity reaction where rapid, early administration of epinephrine (adrenaline) can be lifesaving in the first aid setting.	Epinephrine	110-120	activation induced cytidine deaminase	Homo sapiens	153-156
33312799-14	2020	This scoping review identified limited evidence regarding the use of a second dose of epinephrine for anaphylaxis in the first aid setting, however, due to the potential benefit, it is reasonable to administer a second dose when symptoms of severe anaphylaxis fail to resolve following an initial dose.	Epinephrine	86-97	activation induced cytidine deaminase	Homo sapiens	127-130
32780827-5	2020	Apart from a beneficial effect of low-dose adrenaline (1:1000, 0.25 ml administered subcutaneously) in preventing antivenom-induced hypersensitivities (OR: 0.54, 95% CI 0.32 to 0.93, two RCTs, 354 participants, moderate certainty evidence) in Sri Lanka, evidence for any other adjunct therapy is either non-existent or needs confirmation by larger better designed trials.	Epinephrine	43-53	sorcin	Homo sapiens	243-246
33171955-3	2020	)), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw.	Epinephrine	92-102	phenylethanolamine-N-methyltransferase	Rattus norvegicus	29-67
33171955-3	2020	)), a selective inhibitor of phenylethanolamine N-methyltransferase (PNMT) that converts noradrenaline (NA) into adrenaline (A), fully reverted mechanical allodynia in the injured hind paw without affecting mechanical sensitivity in the contralateral paw.	Epinephrine	92-102	phenylethanolamine-N-methyltransferase	Rattus norvegicus	69-73
33030802-3	2020	This initial observation led us to determine that Prom1 deficiency inhibited cAMP response element-binding protein (CREB) activation and gluconeogenesis, but not cyclic AMP (cAMP) accumulation, in glucagon-, epinephrine-, or forskolin-treated liver tissues and primary hepatocytes, and mitigated glucagon-induced hyperglycemia.	Epinephrine	208-219	prominin 1	Mus musculus	50-55
33153357-11	2022	The LA+Epi group had a higher attainment of MRD1 success (P =0.04) and overall success (P =0.045).	Epinephrine	7-10	methyl-CpG binding domain protein 5	Homo sapiens	44-48
33097799-4	2020	Both surgical injury with HS and counterregulatory hormone (epinephrine) infusion profoundly stimulated adipocyte lipolysis and simultaneously triggered insulin resistance and hyperglycemia.	Epinephrine	60-71	insulin	Homo sapiens	153-160
33192300-4	2020	Some Pnmt-KO mice were administered with EPI or vehicle.	Epinephrine	41-44	phenylethanolamine-N-methyltransferase	Mus musculus	5-9
33192300-9	2020	After PTSD induction, Pnmt-KO mice administered with EPI showed an increase in freezing compared with the vehicle.	Epinephrine	53-56	phenylethanolamine-N-methyltransferase	Mus musculus	22-26
33192300-12	2020	Peripheral administration of EPI restored contextual traumatic memories in Pnmt-KO mice, which suggests a causal role for EPI.	Epinephrine	29-32	phenylethanolamine-N-methyltransferase	Mus musculus	75-79
33087406-0	2020	A Cognitive Aid for Neonatal Epinephrine Dosing.	Epinephrine	29-40	activation induced cytidine deaminase	Homo sapiens	12-15
33087406-4	2020	We hypothesized that the cognitive aid would result in a 25% difference in errors in preparing the dose of epinephrine during simulated neonatal resuscitation.	Epinephrine	107-118	activation induced cytidine deaminase	Homo sapiens	35-38
33087406-11	2020	The aid also decreased errors in choosing the correct epinephrine concentration (12% vs 44%; P < .001), but there was no difference in the written intended dose or the time to prepare the dose.	Epinephrine	54-65	activation induced cytidine deaminase	Homo sapiens	4-7
33087406-13	2020	CONCLUSIONS: A simple cognitive aid decreased epinephrine dosing errors during simulated neonatal resuscitation but did not improve efficiency.	Epinephrine	46-57	activation induced cytidine deaminase	Homo sapiens	32-35
32893983-9	2020	A comparable characterization of the adrenaline-stimulated cyclic PIP synthase is still incomplete.	Epinephrine	37-47	prolactin induced protein	Rattus norvegicus	66-69
33081083-10	2020	Moreover, epinephrine induces a skin stress response characterized by increased expression of G6PD, loricrin, and gammaH2AX biomarkers, and a decrease of OR expression.	Epinephrine	10-21	glucose-6-phosphate dehydrogenase	Homo sapiens	94-98
32822608-4	2020	After characterizing the anatomical complexity among NTS catecholaminergic neurons, we surprisingly found that activation of NTS epinephrine (ENTS) neurons co-expressing neuropeptide Y (NPY) stimulated feeding, whereas activation of NTS norepinephrine (NENTS) neurons suppressed feeding.	Epinephrine	129-140	neuropeptide Y	Homo sapiens	186-189
33081083-10	2020	Moreover, epinephrine induces a skin stress response characterized by increased expression of G6PD, loricrin, and gammaH2AX biomarkers, and a decrease of OR expression.	Epinephrine	10-21	loricrin cornified envelope precursor protein	Homo sapiens	100-108
33178692-5	2020	We chose TrkB as an example because of its relative sensitivity to the effects of epinephrine and due to its potential regulatory role in the beta cell.	Epinephrine	82-93	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	9-13
33178692-7	2020	Micromolar, but not nanomolar, concentrations of epinephrine blocked BDNF-induced TrkB autophosphorylation and downstream mitogen-activated protein kinase pathway activation, suggesting an inhibitory phenomenon at the receptor level.	Epinephrine	49-60	brain derived neurotrophic factor	Mus musculus	69-73
33178692-7	2020	Micromolar, but not nanomolar, concentrations of epinephrine blocked BDNF-induced TrkB autophosphorylation and downstream mitogen-activated protein kinase pathway activation, suggesting an inhibitory phenomenon at the receptor level.	Epinephrine	49-60	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	82-86
33178692-8	2020	We determined epinephrine-mediated inhibition of TrkB activation to be Gi/o-dependent using pertussis toxin, arguing against an off-target effect of high-dose epinephrine.	Epinephrine	14-25	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	49-53
33000941-3	2020	Norepinephrine is very similar in structure and chemical properties to the other two catecholamine neurotransmitters, epinephrine (EP) and dopamine (DA).	Epinephrine	3-14	epiregulin	Homo sapiens	131-133
32856615-9	2020	In vitro, epinephrine treatment upregulated PDK4 expression, inhibited AMPK phosphorylation and enhanced IRS1 phosphorylation.	Epinephrine	10-21	pyruvate dehydrogenase kinase 4	Homo sapiens	44-48
33022918-6	2020	Furthermore, while the plasma levels of low-density lipoprotein cholesterol and epinephrine were significantly reduced in EXP, VO2 peak and grip strength were significantly enhanced (p < 0.05).	Epinephrine	80-91	muscleblind like splicing regulator 1	Homo sapiens	122-125
32856615-9	2020	In vitro, epinephrine treatment upregulated PDK4 expression, inhibited AMPK phosphorylation and enhanced IRS1 phosphorylation.	Epinephrine	10-21	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	71-75
32856615-9	2020	In vitro, epinephrine treatment upregulated PDK4 expression, inhibited AMPK phosphorylation and enhanced IRS1 phosphorylation.	Epinephrine	10-21	insulin receptor substrate 1	Homo sapiens	105-109
32750708-11	2020	In contrast, among Chinese there was a larger proportion of epinephrine-producing paragangliomas, mostly due to HRAS and FGFR1 mutations.	Epinephrine	60-71	HRas proto-oncogene, GTPase	Homo sapiens	112-116
33270597-4	2020	The subcutaneous adrenaline administration to white rats daily for 21 days at a dose of 0.5 mg per 100 g of body weight caused a stress reaction leading to hyperglycemia, fatty hepatodystrophy with the formation of necrosis foci and coarse steatosis on the background of the growth of ALT, AST, and GGT activity by 2.5 and 1.8 times on the 7th day, indicating the cytolytic syndrome with cholestasis.	Epinephrine	17-27	gamma-glutamyltransferase 1	Rattus norvegicus	299-302
32750708-11	2020	In contrast, among Chinese there was a larger proportion of epinephrine-producing paragangliomas, mostly due to HRAS and FGFR1 mutations.	Epinephrine	60-71	fibroblast growth factor receptor 1	Homo sapiens	121-126
32522698-10	2020	Plasma levels of iFABP were not associated with time to ROSC but correlated with epinephrine-dose (R=0.32; p<0.05).	Epinephrine	81-92	fatty acid binding protein 2	Homo sapiens	17-22
32522698-11	2020	40% of patients receiving >=3mg of epinephrine as compared to 10.5% of patients treated with<3mg (p<0.05) developed iFABP plasma levels>1500pg/mL, which was associated with dramatically increased mortality (HR4.87, 95%CI 1.95-12.1; p<0.001).	Epinephrine	35-46	fatty acid binding protein 2	Homo sapiens	116-121
32562431-7	2020	When intercrossed pregnant dams were fed with synthetic adrenaline analogs, the lethality of the Gata2 NC-CKO embryos was partially rescued, indicating that placental transfer of the adrenaline analogs complements the lethal catecholamine-deficiency in the Gata2 NC-CKO embryos.	Epinephrine	56-66	GATA binding protein 2	Mus musculus	257-262
33117176-3	2020	They are related to two other adrenergic receptor families that also bind norepinephrine and epinephrine, the beta- and alpha2-, each with three subtypes (beta1, beta2, beta3, alpha2A, alpha2B, alpha2C).	Epinephrine	77-88	G protein-coupled receptor 162	Homo sapiens	120-126
33042003-7	2020	Also, the STZ-treated ghrelin-KO mice exhibited attenuated plasma epinephrine and norepinephrine responses to the insulin-induced hypoglycemia.	Epinephrine	66-77	insulin	Homo sapiens	114-121
32562431-7	2020	When intercrossed pregnant dams were fed with synthetic adrenaline analogs, the lethality of the Gata2 NC-CKO embryos was partially rescued, indicating that placental transfer of the adrenaline analogs complements the lethal catecholamine-deficiency in the Gata2 NC-CKO embryos.	Epinephrine	183-193	GATA binding protein 2	Mus musculus	97-102
32562431-7	2020	When intercrossed pregnant dams were fed with synthetic adrenaline analogs, the lethality of the Gata2 NC-CKO embryos was partially rescued, indicating that placental transfer of the adrenaline analogs complements the lethal catecholamine-deficiency in the Gata2 NC-CKO embryos.	Epinephrine	183-193	GATA binding protein 2	Mus musculus	257-262
32562431-8	2020	These results demonstrate that GATA2 participates in the development of neuroendocrine adrenaline biosynthesis, which is essential for fetal survival.	Epinephrine	87-97	GATA binding protein 2	Mus musculus	31-36
33060881-11	2020	Results: In non-LF rats, mepivacaine, lidocaine, and lidocaine with epinephrine caused a significant increase in aspartate aminotransferase (AST) level compared with the effect of prilocaine with felypressin and articaine.	Epinephrine	68-79	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	113-139
33060881-11	2020	Results: In non-LF rats, mepivacaine, lidocaine, and lidocaine with epinephrine caused a significant increase in aspartate aminotransferase (AST) level compared with the effect of prilocaine with felypressin and articaine.	Epinephrine	68-79	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	141-144
32743060-3	2020	Topical epinephrine has shown mixed results and is still not widely accepted as an alternative for prevention of PEP.	Epinephrine	8-19	prolyl endopeptidase	Homo sapiens	113-116
33005504-5	2020	A ketogenic diet consists of high fat, low carbohydrate, and adequate protein regimen that sends the body into a state of starvation in which high glucagon and low insulin levels lead to the activation of other counter-regulatory hormones, such as epinephrine and cortisol, that causes a rise in the level of free fatty acids in the blood increasing ketone body production.	Epinephrine	248-259	glucagon	Homo sapiens	147-155
32767120-9	2020	The expression and release of inflammatory factors including NGF were enhanced by epinephrine.	Epinephrine	82-93	nerve growth factor	Mus musculus	61-64
32743060-13	2020	In subgroup analysis, topical epinephrine appeared to decrease risk of PEP in the absence of rectal indomethacin, and could be considered when rectal indomethacin is unavailable or if there is a contraindication to its use.	Epinephrine	30-41	prolyl endopeptidase	Homo sapiens	71-74
32743060-4	2020	We performed a systematic review and meta-analysis to evaluate the efficacy of topical epinephrine in preventing PEP.	Epinephrine	87-98	prolyl endopeptidase	Homo sapiens	113-116
32743060-5	2020	Methods  A comprehensive literature review was conducted by searching Cochrane library database, Embase and PubMed up to August 2019, to identify all studies that evaluated use of topical epinephrine alone or in conjunction with other agents for prevention of PEP.	Epinephrine	188-199	prolyl endopeptidase	Homo sapiens	260-263
32743060-6	2020	Outcomes included prevention of PEP with use of topical epinephrine and evaluation of whether addiing epinephrine provides any additional benefit in preventing PEP.	Epinephrine	102-113	prolyl endopeptidase	Homo sapiens	160-163
32743060-10	2020	However, on a subgroup analysis, topical epinephrine significantly decreases the risk of PEP when compared to placebo alone (means no intervention was done including no rectal indomethacin)., RR = 0.32 (0.18-0.57).	Epinephrine	41-52	prolyl endopeptidase	Homo sapiens	89-92
32437023-0	2020	Biophysical defects of an SCN5A V1667I mutation associated with epinephrine-induced marked QT prolongation.	Epinephrine	64-75	sodium voltage-gated channel alpha subunit 5	Homo sapiens	26-31
32437023-1	2020	BACKGROUND: The epinephrine infusion test (EIT) typically induces marked QT prolongation in LQT1, but not LQT3, while the efficacy of beta-blocker therapy is established in LQT1, but not LQT3.	Epinephrine	16-27	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	92-96
32437023-1	2020	BACKGROUND: The epinephrine infusion test (EIT) typically induces marked QT prolongation in LQT1, but not LQT3, while the efficacy of beta-blocker therapy is established in LQT1, but not LQT3.	Epinephrine	16-27	sodium voltage-gated channel alpha subunit 5	Homo sapiens	187-191
32437023-2	2020	We encountered an LQT3 family, with an SCN5A V1667I mutation, that exhibited epinephrine-induced marked QT prolongation.	Epinephrine	77-88	sodium voltage-gated channel alpha subunit 5	Homo sapiens	18-22
32562431-7	2020	When intercrossed pregnant dams were fed with synthetic adrenaline analogs, the lethality of the Gata2 NC-CKO embryos was partially rescued, indicating that placental transfer of the adrenaline analogs complements the lethal catecholamine-deficiency in the Gata2 NC-CKO embryos.	Epinephrine	56-66	GATA binding protein 2	Mus musculus	97-102
32344126-8	2020	These results indicate that P-gp has an important role in drug absorption and efflux at nasal cavity, while adrenaline is also able to modify the penetration profile of the P-gp substrate model drug at nasal application as it decreases nose-to-blood absorption, letting more quinidine to reach the brain along with the nasal nerves.	Epinephrine	108-118	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	173-177
32241223-4	2020	After restimulation with LPS on day 6, (nor)adrenaline-exposed cells showed increased TNF-alpha production.	Epinephrine	44-54	tumor necrosis factor	Homo sapiens	86-95
32437023-2	2020	We encountered an LQT3 family, with an SCN5A V1667I mutation, that exhibited epinephrine-induced marked QT prolongation.	Epinephrine	77-88	sodium voltage-gated channel alpha subunit 5	Homo sapiens	39-44
32443169-4	2020	RESULTS: Considerable variationsin calculated plasma epinephrine concentration were detected between flow rates of 5 and 0.5 or 1 mLh-1 for all syringe types and filling volumes.	Epinephrine	53-64	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	Mus musculus	130-135
32295910-8	2020	Further, 17dmiR-H1/H6 was severely impaired in epinephrine-induced reactivation in the rabbit ocular model.	Epinephrine	47-58	histocompatibility 1	Mus musculus	16-21
33088330-7	2020	Structure- based virtual screening suggested histamine, epinephrine, and capreomycin as potential hits which could be repurposed as Mxra8 inhibitor.	Epinephrine	56-67	matrix remodeling associated 8	Homo sapiens	132-137
32406234-6	2020	Arrays of HD-CNTf rods microelectrode were applied to detect neurotransmitters i.e. dopamine (DA), serotonin (5-HT), epinephrine (Epn) and nor-epinephrine (Nor-epn) using voltammetric techniques.	Epinephrine	130-133	ciliary neurotrophic factor	Homo sapiens	13-17
32612281-6	2020	EA at PC6 resulted in downregulation of adenosine, adrenaline, gamma-aminobutyric acid, glycine, and glutamate majorly in hippocampus, and then in cerebral cortex.	Epinephrine	51-61	proprotein convertase subtilisin/kexin type 5	Rattus norvegicus	6-9
32526790-7	2020	Epinephrine response was stronger in large platelets (CD62P-expression: 11.8 MFI [6.8-33.0] vs. 6.8 MFI [2.5-15.2], p = 0.0078; PAC-1 binding 18.9 MFI [13.6-38.4] vs. 13.0 MFI [6.8-22.4], p = 0.0234; max.	Epinephrine	0-11	selectin P	Homo sapiens	54-59
32526790-7	2020	Epinephrine response was stronger in large platelets (CD62P-expression: 11.8 MFI [6.8-33.0] vs. 6.8 MFI [2.5-15.2], p = 0.0078; PAC-1 binding 18.9 MFI [13.6-38.4] vs. 13.0 MFI [6.8-22.4], p = 0.0234; max.	Epinephrine	0-11	ADCYAP receptor type I	Homo sapiens	128-133
32526790-11	2020	Thrombin generation was faster with small, but accelerated by PS exposure and epinephrine-coactivated large platelets.	Epinephrine	78-89	coagulation factor II, thrombin	Homo sapiens	0-8
32670638-2	2020	HR at the time of the return of spontaneous circulation (ROSC) could be influenced by the beta1-adrenergic effect of the epinephrine administered during cardiopulmonary resuscitation (CPR), and its effect could be decreased in patients who have the failing heart.	Epinephrine	121-132	BCL2 related protein A1	Homo sapiens	90-95
32483173-4	2020	In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by beta2-adrenergic receptor (beta2-AR) activation thus delay wound healing.	Epinephrine	39-50	adrenergic receptor, beta 2	Mus musculus	99-124
32246922-10	2020	These findings suggest that normetadrenaline and metadrenaline act as a partial alpha1D/alpha1A-adrenoceptor agonist and partial alpha1D-adrenoceptor/full alpha1A-adrenoceptor agonist, respectively, functioning as adrenaline system stabilizers in alpha1D/alpha1A-adrenoceptor-abundant smooth muscle tissues.	Epinephrine	34-44	adrenoceptor alpha 1A	Rattus norvegicus	88-108
32246922-10	2020	These findings suggest that normetadrenaline and metadrenaline act as a partial alpha1D/alpha1A-adrenoceptor agonist and partial alpha1D-adrenoceptor/full alpha1A-adrenoceptor agonist, respectively, functioning as adrenaline system stabilizers in alpha1D/alpha1A-adrenoceptor-abundant smooth muscle tissues.	Epinephrine	34-44	adrenoceptor alpha 1D	Rattus norvegicus	129-149
32246922-10	2020	These findings suggest that normetadrenaline and metadrenaline act as a partial alpha1D/alpha1A-adrenoceptor agonist and partial alpha1D-adrenoceptor/full alpha1A-adrenoceptor agonist, respectively, functioning as adrenaline system stabilizers in alpha1D/alpha1A-adrenoceptor-abundant smooth muscle tissues.	Epinephrine	34-44	adrenoceptor alpha 1A	Rattus norvegicus	155-175
32246922-10	2020	These findings suggest that normetadrenaline and metadrenaline act as a partial alpha1D/alpha1A-adrenoceptor agonist and partial alpha1D-adrenoceptor/full alpha1A-adrenoceptor agonist, respectively, functioning as adrenaline system stabilizers in alpha1D/alpha1A-adrenoceptor-abundant smooth muscle tissues.	Epinephrine	34-44	adrenoceptor alpha 1A	Rattus norvegicus	155-175
32483173-4	2020	In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by beta2-adrenergic receptor (beta2-AR) activation thus delay wound healing.	Epinephrine	39-50	adenosine A2a receptor	Homo sapiens	126-134
32483173-4	2020	In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by beta2-adrenergic receptor (beta2-AR) activation thus delay wound healing.	Epinephrine	52-55	adrenergic receptor, beta 2	Mus musculus	99-124
32483173-4	2020	In wounded skin, keratinocytes produce epinephrine (EPI) that leads to cell motility inhibition by beta2-adrenergic receptor (beta2-AR) activation thus delay wound healing.	Epinephrine	52-55	adenosine A2a receptor	Homo sapiens	126-134
32483173-5	2020	As beta2-AR antagonists, TA and dopamine (DOP) abrogate the effect of EPI thus accelerating wound healing both in vitro and in a mouse model.	Epinephrine	70-73	adenosine A2a receptor	Mus musculus	3-11
32486261-7	2020	Interestingly, platelet aggregation induced by co-stimulation of serotonin and epinephrine which activate Gq-coupled 5HT2A and Gz-coupled 2A adrenergic receptors, respectively, was not affected in GRK6-/- platelets, suggesting that GRK6 was involved in specific GPCR regulation.	Epinephrine	79-90	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	117-122
31635605-4	2020	The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods showed a wide linear response to a concentration range, from 1.71 to 55.00 muM, and the epinephrine detection limit for this sensing system was found to be 1.334 muM.	Epinephrine	165-176	latexin	Homo sapiens	152-155
32409296-7	2020	Consistent with epinephrine in CSF being bound by RF and required for urp expression, treating sspo mutants with this catecholamine rescued expression of the urp genes and axial defects.	Epinephrine	16-27	urotensin 2B	Homo sapiens	70-73
32409296-7	2020	Consistent with epinephrine in CSF being bound by RF and required for urp expression, treating sspo mutants with this catecholamine rescued expression of the urp genes and axial defects.	Epinephrine	16-27	SCO-spondin, pseudogene	Homo sapiens	95-99
32409296-7	2020	Consistent with epinephrine in CSF being bound by RF and required for urp expression, treating sspo mutants with this catecholamine rescued expression of the urp genes and axial defects.	Epinephrine	16-27	urotensin 2B	Homo sapiens	158-161
31635605-4	2020	The cyclic voltammetry (CV) and differential pulse voltammetry (DPV) methods showed a wide linear response to a concentration range, from 1.71 to 55.00 muM, and the epinephrine detection limit for this sensing system was found to be 1.334 muM.	Epinephrine	165-176	latexin	Homo sapiens	239-242
31855300-0	2020	Epistasis between Phenylethanolamine N-methyltransferase (PNMT) and beta2-adrenergic receptor (ADRB2) Influences Extracellular Epinephrine Level and Associates with the Susceptibility to Allergic Asthma.	Epinephrine	127-138	phenylethanolamine N-methyltransferase	Homo sapiens	18-56
32388084-5	2020	ALE suppressed TNF-alpha-induced monocyte adhesion to the vascular endothelium by suppressing NF-kappaB signaling in HUVECs.	Epinephrine	0-3	tumor necrosis factor	Mus musculus	15-24
32388084-6	2020	In an acute mouse model of atherosclerosis, ALE suppressed TNF-alpha-induced monocyte infiltration of the vascular endothelium and the expression of genes encoding inflammatory cytokines including IL-1beta, IL-6, TNF-alpha, and MCP-1 in the mouse aorta.	Epinephrine	44-47	tumor necrosis factor	Mus musculus	59-68
32388084-6	2020	In an acute mouse model of atherosclerosis, ALE suppressed TNF-alpha-induced monocyte infiltration of the vascular endothelium and the expression of genes encoding inflammatory cytokines including IL-1beta, IL-6, TNF-alpha, and MCP-1 in the mouse aorta.	Epinephrine	44-47	interleukin 1 alpha	Mus musculus	197-205
32388084-6	2020	In an acute mouse model of atherosclerosis, ALE suppressed TNF-alpha-induced monocyte infiltration of the vascular endothelium and the expression of genes encoding inflammatory cytokines including IL-1beta, IL-6, TNF-alpha, and MCP-1 in the mouse aorta.	Epinephrine	44-47	interleukin 6	Mus musculus	207-211
32388084-6	2020	In an acute mouse model of atherosclerosis, ALE suppressed TNF-alpha-induced monocyte infiltration of the vascular endothelium and the expression of genes encoding inflammatory cytokines including IL-1beta, IL-6, TNF-alpha, and MCP-1 in the mouse aorta.	Epinephrine	44-47	tumor necrosis factor	Mus musculus	213-222
32388084-6	2020	In an acute mouse model of atherosclerosis, ALE suppressed TNF-alpha-induced monocyte infiltration of the vascular endothelium and the expression of genes encoding inflammatory cytokines including IL-1beta, IL-6, TNF-alpha, and MCP-1 in the mouse aorta.	Epinephrine	44-47	mast cell protease 1	Mus musculus	228-233
32321314-7	2021	Co-treatment with the nonselective adrenaline blocker carvedilol attenuated the BF increase seen with 10 microg/kg A2 treatment.	Epinephrine	35-45	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	115-117
32045472-3	2020	We demonstrate here a role for the beta2-adrenergic receptor (beta2-AR), which binds the stress mediators adrenaline and noradrenaline, in modulating host response to mouse cytomegalovirus (MCMV) infection.	Epinephrine	106-116	adrenergic receptor, beta 2	Mus musculus	35-60
32045472-3	2020	We demonstrate here a role for the beta2-adrenergic receptor (beta2-AR), which binds the stress mediators adrenaline and noradrenaline, in modulating host response to mouse cytomegalovirus (MCMV) infection.	Epinephrine	106-116	adenosine A2a receptor	Mus musculus	62-70
32318239-8	2020	Epigenetic DNMT inhibition (DNMTi) or HDAC inhibition (HDACi) also successfully attenuated elevations in the majority of altered catecholamine (CA) enzyme expression, phenylethanolamine N-methyltransferase (PNMT) protein, and elevated epinephrine (Epi) levels in males.	Epinephrine	0-3	phenylethanolamine-N-methyltransferase	Rattus norvegicus	167-205
32318239-8	2020	Epigenetic DNMT inhibition (DNMTi) or HDAC inhibition (HDACi) also successfully attenuated elevations in the majority of altered catecholamine (CA) enzyme expression, phenylethanolamine N-methyltransferase (PNMT) protein, and elevated epinephrine (Epi) levels in males.	Epinephrine	0-3	phenylethanolamine-N-methyltransferase	Rattus norvegicus	207-211
32188130-6	2020	We compared in vitro the efficacy of clonidine, dexmedetomidine, brimonidine, and norepinephrine with epinephrine to restore ADP- and PAR-1-AP-induced washed platelet aggregation inhibited by ticagrelor, as well as resulting platelet cAMP levels.	Epinephrine	85-96	Prader Willi/Angelman region RNA 1	Homo sapiens	134-139
32043995-7	2020	The detection limits of noradrenaline, adrenaline, and dopamine were 0.1, 0.1, and 0.2 muM, respectively.	Epinephrine	27-37	latexin	Homo sapiens	87-90
31755606-13	2020	Use of the PAF-R antagonist had a synergistic effect with epinephrine and allowed a significant reduction in epinephrine consumption.	Epinephrine	58-69	platelet-activating factor receptor	Rattus norvegicus	11-16
31755606-13	2020	Use of the PAF-R antagonist had a synergistic effect with epinephrine and allowed a significant reduction in epinephrine consumption.	Epinephrine	109-120	platelet-activating factor receptor	Rattus norvegicus	11-16
31755606-14	2020	Use of PAF-R antagonists during AS, could reduce epinephrine-related complications and improve the treatment of epinephrine refractory cases.	Epinephrine	49-60	platelet-activating factor receptor	Rattus norvegicus	7-12
31755606-14	2020	Use of PAF-R antagonists during AS, could reduce epinephrine-related complications and improve the treatment of epinephrine refractory cases.	Epinephrine	112-123	platelet-activating factor receptor	Rattus norvegicus	7-12
32300655-5	2020	TRPV1-dependent calcium influx into the cells of adrenal cortex and medulla is sufficient to drive rapid release of corticosterone and (nor)epinephrine.	Epinephrine	140-151	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
32047262-6	2020	Furthermore, pretreatment with GA A caused significantly higher adrenaline content in SH-SY5Y cells than in PC12 cells.	Epinephrine	64-74	alpha glucosidase	Homo sapiens	31-35
32047262-7	2020	In order to elucidate the mechanism of GA A-protecting SH-SY5Y cells, we added adrenaline, phentolamine, metoprolol, or ICI 118551 1 h before GA A was added to the culture medium.	Epinephrine	79-89	alpha glucosidase	Homo sapiens	39-43
32047262-8	2020	We found that addition of adrenaline (10 muM) significantly improved GA A protection in PC12 cells.	Epinephrine	26-36	latexin	Homo sapiens	41-44
32047262-8	2020	We found that addition of adrenaline (10 muM) significantly improved GA A protection in PC12 cells.	Epinephrine	26-36	alpha glucosidase	Rattus norvegicus	69-73
32104923-6	2020	We further found that AKG stimulates the adrenal release of adrenaline through 2-oxoglutarate receptor 1 (OXGR1) expressed in adrenal glands.	Epinephrine	60-70	oxoglutarate receptor 1	Homo sapiens	106-111
31770654-9	2020	Anaphylaxis treated with epinephrine was reported by 24% (n=134) of leadership within the previous 2 years at their camp.	Epinephrine	25-36	cathelicidin antimicrobial peptide	Homo sapiens	116-120
32035089-1	2020	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step for the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Epinephrine	127-137	tyrosine hydroxylase	Mus musculus	12-32
32035089-1	2020	BACKGROUND: Tyrosine hydroxylase (TH) catalyzes the rate-limiting step for the biosynthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Epinephrine	127-137	tyrosine hydroxylase	Mus musculus	34-36
31855300-0	2020	Epistasis between Phenylethanolamine N-methyltransferase (PNMT) and beta2-adrenergic receptor (ADRB2) Influences Extracellular Epinephrine Level and Associates with the Susceptibility to Allergic Asthma.	Epinephrine	127-138	phenylethanolamine N-methyltransferase	Homo sapiens	58-62
31855300-0	2020	Epistasis between Phenylethanolamine N-methyltransferase (PNMT) and beta2-adrenergic receptor (ADRB2) Influences Extracellular Epinephrine Level and Associates with the Susceptibility to Allergic Asthma.	Epinephrine	127-138	adrenoceptor beta 2	Homo sapiens	68-93
31855300-0	2020	Epistasis between Phenylethanolamine N-methyltransferase (PNMT) and beta2-adrenergic receptor (ADRB2) Influences Extracellular Epinephrine Level and Associates with the Susceptibility to Allergic Asthma.	Epinephrine	127-138	adrenoceptor beta 2	Homo sapiens	95-100
31855300-2	2020	OBJECTIVE: To characterize the functions of single nucleotide polymorphisms (SNPs) in Phenylethanolamine N-methyltransferase (PNMT) and beta2-adrenergic receptor (ADRB2), and study the effects, including both direct and epistatic, of these SNPs on serum epinephrine level and asthma susceptibility.	Epinephrine	254-265	phenylethanolamine N-methyltransferase	Homo sapiens	86-124
31855300-2	2020	OBJECTIVE: To characterize the functions of single nucleotide polymorphisms (SNPs) in Phenylethanolamine N-methyltransferase (PNMT) and beta2-adrenergic receptor (ADRB2), and study the effects, including both direct and epistatic, of these SNPs on serum epinephrine level and asthma susceptibility.	Epinephrine	254-265	phenylethanolamine N-methyltransferase	Homo sapiens	126-130
31855300-12	2020	CONCLUSION AND CLINICAL RELEVANCE: Epistatic interaction between genetic variants from PNMT (rs876493) and ADRB2 (rs11168070) is associated with serum epinephrine level and the susceptibility of asthma.	Epinephrine	151-162	phenylethanolamine N-methyltransferase	Homo sapiens	87-91
31855300-12	2020	CONCLUSION AND CLINICAL RELEVANCE: Epistatic interaction between genetic variants from PNMT (rs876493) and ADRB2 (rs11168070) is associated with serum epinephrine level and the susceptibility of asthma.	Epinephrine	151-162	adrenoceptor beta 2	Homo sapiens	107-112
32067305-5	2020	Transplanted patients with food allergy having received a prescription of epinephrine had a significantly higher total IgE (2033 [234-2831] vs 10 [5-41] IU/L, P = .002) and MIP-1b (52 [37-96] vs 36 [32-39], P = .035) compared with transplanted patients without food allergy.	Epinephrine	74-85	C-C motif chemokine ligand 4	Homo sapiens	173-179
32162598-1	2020	Aim: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of sympathetic neurotransmitter norepinephrine to epinephrine.	Epinephrine	111-122	phenylethanolamine N-methyltransferase	Homo sapiens	5-43
32162598-1	2020	Aim: Phenylethanolamine N-methyltransferase (PNMT) catalyzes the conversion of sympathetic neurotransmitter norepinephrine to epinephrine.	Epinephrine	111-122	phenylethanolamine N-methyltransferase	Homo sapiens	45-49
30442676-0	2020	Guideline review: Epinephrine use in anaphylaxis (AAP guideline 2017).	Epinephrine	18-29	serpin family F member 2	Homo sapiens	50-53
32128053-6	2020	Epinephrine was prescribed in 21% of ACE angioedema cases.	Epinephrine	0-11	angiotensin I converting enzyme	Homo sapiens	37-40
31831958-2	2019	Molecular dynamics simulation (MDS) and docking analysis of biogenic monoamines with ceruloplasmin explain the role of Asp1025, Glu935, Glu272, Glu232 and Glu230 together with the binding site water molecules (referred as conserved water molecules) in the stabilization of neurotransmitter (Serotonin, Norepinephrine and Epinephrine) molecules within the binding cavity of hCP.	Epinephrine	321-332	ceruloplasmin	Homo sapiens	85-98
31952633-5	2020	Glucose stimulated (P &lt; .05) insulin release in controls at 5 minutes that persisted through 30 minutes; insulin was suppressed (P &lt; .05) by epinephrine from 5 to 15 minutes, rising gradually through 30 minutes.	Epinephrine	147-158	INS	Equus caballus	108-115
32061187-8	2020	Similarly, epinephrine-induced increases in the mRNA expression of hepatic adrenergic receptors (Adra1/2a, Adrb1), and glucose-6-phosphatase (G6pc) were greater in sedentary compared to trained mice.	Epinephrine	11-22	adrenergic receptor, alpha 1d	Mus musculus	97-105
32061187-8	2020	Similarly, epinephrine-induced increases in the mRNA expression of hepatic adrenergic receptors (Adra1/2a, Adrb1), and glucose-6-phosphatase (G6pc) were greater in sedentary compared to trained mice.	Epinephrine	11-22	adrenergic receptor, beta 1	Mus musculus	107-112
32061187-8	2020	Similarly, epinephrine-induced increases in the mRNA expression of hepatic adrenergic receptors (Adra1/2a, Adrb1), and glucose-6-phosphatase (G6pc) were greater in sedentary compared to trained mice.	Epinephrine	11-22	glucose-6-phosphatase, catalytic	Mus musculus	119-140
32061187-8	2020	Similarly, epinephrine-induced increases in the mRNA expression of hepatic adrenergic receptors (Adra1/2a, Adrb1), and glucose-6-phosphatase (G6pc) were greater in sedentary compared to trained mice.	Epinephrine	11-22	glucose-6-phosphatase, catalytic	Mus musculus	142-146
32843785-5	2020	They were given half milliliter of solution containing 2.5 mug of adrenaline with insulin syringe.	Epinephrine	66-76	insulin	Homo sapiens	82-89
30821508-4	2020	reduced DbetaH activity by 93% and 80% in the adrenals at 4 h and 8 h postdrug administration, accompanied by significant reductions in NE and epinephrine tissue levels and an increase in DA levels and of DA/NE tissue ratios, with similar findings for NE, DA and of DA/NE tissue ratios in left ventricle and kidney.	Epinephrine	143-154	dopamine beta-hydroxylase	Rattus norvegicus	8-14
31746824-5	2019	Herein, P-1 Pdots with the strongest ECL signal were successfully used as ECL biosensors for the detection of catechol, epinephrine and dopamine with detection limits of 1, 7 and 3 nM, respectively.	Epinephrine	120-131	crystallin gamma F, pseudogene	Homo sapiens	8-11
31722552-5	2019	It includes revised recommendations for all 3 areas, including the choice of advanced airway devices and strategies during cardiac arrest (eg, bag-mask ventilation, supraglottic airway, or endotracheal intubation), the training and retraining required, the administration of standard-dose epinephrine, and the decisions involved in the application of extracorporeal cardiopulmonary resuscitation and its potential impact on cardiac arrest survival.	Epinephrine	289-300	paired box 5	Homo sapiens	40-45
31334620-0	2019	Atropine or adrenaline plus atropine may constitute appropriate treatment for cardiac arrest caused by intramyometrial injection of vasopressin.	Epinephrine	12-22	arginine vasopressin	Homo sapiens	132-143
31646370-10	2019	In norepinephrine-refractory patients, vasopressin or epinephrine may be added.	Epinephrine	6-17	arginine vasopressin	Homo sapiens	39-50
31556016-1	2019	BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine.	Epinephrine	145-156	monoamine oxidase A	Homo sapiens	16-36
31556016-1	2019	BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine.	Epinephrine	145-156	monoamine oxidase A	Homo sapiens	38-43
31556016-1	2019	BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine.	Epinephrine	165-176	monoamine oxidase A	Homo sapiens	16-36
31556016-1	2019	BACKGROUND: The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine.	Epinephrine	165-176	monoamine oxidase A	Homo sapiens	38-43
31738933-8	2020	Epinephrine alone failed to induce aggregation whereas it fully induced VASP dephosphorylation and Akt phosphorylation regardless of the presence of ticagrelor.	Epinephrine	0-11	vasodilator stimulated phosphoprotein	Homo sapiens	72-76
31738933-8	2020	Epinephrine alone failed to induce aggregation whereas it fully induced VASP dephosphorylation and Akt phosphorylation regardless of the presence of ticagrelor.	Epinephrine	0-11	AKT serine/threonine kinase 1	Homo sapiens	99-102
31738933-9	2020	In the presence of ticagrelor, blockage of the P2Y1 receptor prevented restoration of platelet aggregation by the combination of epinephrine and ADP, as well as intracellular Ca2+ mobilisation.	Epinephrine	129-140	purinergic receptor P2Y1	Homo sapiens	47-60
31738933-10	2020	In combination with ADP, epinephrine induced platelet aggregation of ticagrelor-treated platelets through inhibition of the cAMP pathway and activation of the PI3K pathway, thus enabling the P2Y1 receptor signalling and subsequent Ca2+ mobilisation.	Epinephrine	25-36	purinergic receptor P2Y1	Homo sapiens	191-204
31627809-1	2019	In this paper, a novel and sensitive ratiometric fluorescence strategy for the detection of epinephrine (EP) and ascorbic acid (AA) was established based on the fluorescence resonance energy transfer (FRET) between the molybdenum disulfide quantum dots (MQDs) and the fluorescent oxidative polymerization product (PEP-PEI) of EP in polyethyleneimine (PEI) aqueous solution.	Epinephrine	92-103	epiregulin	Homo sapiens	105-107
31627809-1	2019	In this paper, a novel and sensitive ratiometric fluorescence strategy for the detection of epinephrine (EP) and ascorbic acid (AA) was established based on the fluorescence resonance energy transfer (FRET) between the molybdenum disulfide quantum dots (MQDs) and the fluorescent oxidative polymerization product (PEP-PEI) of EP in polyethyleneimine (PEI) aqueous solution.	Epinephrine	92-103	prolyl endopeptidase	Homo sapiens	314-317
31627809-1	2019	In this paper, a novel and sensitive ratiometric fluorescence strategy for the detection of epinephrine (EP) and ascorbic acid (AA) was established based on the fluorescence resonance energy transfer (FRET) between the molybdenum disulfide quantum dots (MQDs) and the fluorescent oxidative polymerization product (PEP-PEI) of EP in polyethyleneimine (PEI) aqueous solution.	Epinephrine	92-103	epiregulin	Homo sapiens	315-317
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Epinephrine	14-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-61
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Epinephrine	14-25	prostaglandin D2 synthase	Homo sapiens	77-81
31425733-4	2019	We found that epinephrine and norepinephrine up-regulate COX2 expression and PGD2 production through beta1-and beta2-ADRs.	Epinephrine	14-25	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	101-116
31669824-8	2019	Moreover, venous thromboembolism (VTE) after injection of collagen/epinephrine in the jugular vein was reduced in Panx1-/- and Panx1PDel mice.	Epinephrine	67-78	pannexin 1	Mus musculus	114-119
31669824-8	2019	Moreover, venous thromboembolism (VTE) after injection of collagen/epinephrine in the jugular vein was reduced in Panx1-/- and Panx1PDel mice.	Epinephrine	67-78	pannexin 1	Mus musculus	127-136
31247151-0	2019	The Surprising Reintroduction of Primatene  Mist in the United States.	Epinephrine	33-42	cytokine dependent hematopoietic cell linker	Homo sapiens	44-48
31431258-7	2019	Formation of heat-induced insulin aggregation can be effectively inhibited by 1 mM eugenol and epinephrine and both compounds were found to preserve insulin activity to a considerable extent.	Epinephrine	95-106	insulin	Homo sapiens	26-33
31603552-12	2019	The low levels of ARG, homoarginine, and citrulline may be the consequence of high circulating levels of alpha1 -agonists, such as epinephrine and norepinephrine, and their biochemical interaction with endothelial trace amine-associated receptor 1 that induces activation of NO synthase, resulting in NO synthesis in the circulation, NO release, intense vasodilation, and as a result, the cluster attack.	Epinephrine	131-142	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	18-21
31603552-12	2019	The low levels of ARG, homoarginine, and citrulline may be the consequence of high circulating levels of alpha1 -agonists, such as epinephrine and norepinephrine, and their biochemical interaction with endothelial trace amine-associated receptor 1 that induces activation of NO synthase, resulting in NO synthesis in the circulation, NO release, intense vasodilation, and as a result, the cluster attack.	Epinephrine	131-142	BCL2 related protein A1	Homo sapiens	105-111
31484636-7	2019	Furthermore, NO loading of SSRBCs increased S-nitrosohemoglobin and modulated epinephrine"s effect by upregulating phosphorylation of membrane proteins, including pyruvate kinase, E3 ubiquitin ligase, and the cytoskeletal protein 4.1.	Epinephrine	78-89	erythrocyte membrane protein band 4.1	Homo sapiens	209-233
31595165-0	2019	Circ-HIPK3 Strengthens the Effects of Adrenaline in Heart Failure by MiR-17-3p - ADCY6 Axis.	Epinephrine	38-48	homeodomain interacting protein kinase 3	Mus musculus	5-10
31510078-9	2019	Our results suggest that the antioxidant activity of ALE in C. elegans is independent of its alkaloid content, and that SKN-1 is required for ALE-mediated stress resistance.	Epinephrine	142-145	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	120-125
31595165-0	2019	Circ-HIPK3 Strengthens the Effects of Adrenaline in Heart Failure by MiR-17-3p - ADCY6 Axis.	Epinephrine	38-48	adenylate cyclase 6	Mus musculus	81-86
31595165-6	2019	And further assays showed that the level of circ-HIPK3 in heart was upregulated by adrenaline via transcription factor CREB1 (cAMP responsive element-binding protein 1).	Epinephrine	83-93	homeodomain interacting protein kinase 3	Mus musculus	49-54
31595165-6	2019	And further assays showed that the level of circ-HIPK3 in heart was upregulated by adrenaline via transcription factor CREB1 (cAMP responsive element-binding protein 1).	Epinephrine	83-93	cAMP responsive element binding protein 1	Mus musculus	119-124
31595165-6	2019	And further assays showed that the level of circ-HIPK3 in heart was upregulated by adrenaline via transcription factor CREB1 (cAMP responsive element-binding protein 1).	Epinephrine	83-93	cAMP responsive element binding protein 1	Mus musculus	126-167
31595165-8	2019	In conclusion, the increased circ-HIPK3 can be a helper for adrenaline but was harmful for heart in the long run and might be an ideal therapeutic target of HF.	Epinephrine	60-70	homeodomain interacting protein kinase 3	Mus musculus	34-39
31483805-3	2019	Here, we used a WKY rat model and studied the molecular changes triggered by prenatal glucocorticoid (GC) exposure on the development of hypertension, and on the regulation of phenylethanolamine N-methyl transferase (PNMT), the enzyme responsible for biosynthesis of epinephrine, and a candidate gene linked to hypertension.	Epinephrine	267-278	phenylethanolamine-N-methyltransferase	Rattus norvegicus	176-215
31279527-7	2019	The down-regulation of NT5DC2 by siRNA increased the synthesis of catecholamines (dopamine, noradrenaline, and adrenaline) in PC12D cells.	Epinephrine	95-105	5'-nucleotidase domain containing 2	Rattus norvegicus	23-29
31393950-6	2019	Treatment with calphostin C, PTIO, ODQ or KT5823, respective inhibitors of PKC, NO, soluble guanylate cyclase and PKG, abrogated completely the effect of epinephrine and PGE2, suggesting an involvement of these mediators.	Epinephrine	154-165	proline rich transmembrane protein 2	Homo sapiens	75-78
31393950-6	2019	Treatment with calphostin C, PTIO, ODQ or KT5823, respective inhibitors of PKC, NO, soluble guanylate cyclase and PKG, abrogated completely the effect of epinephrine and PGE2, suggesting an involvement of these mediators.	Epinephrine	154-165	protein kinase cGMP-dependent 1	Homo sapiens	114-117
31393950-10	2019	The data support a pathway in which epinephrine induces the production of PGE2 which binds to EP1 receptors and activates PKC and NF-kappaB leading to NO synthesis.	Epinephrine	36-47	prostaglandin E receptor 1	Homo sapiens	94-97
31393950-10	2019	The data support a pathway in which epinephrine induces the production of PGE2 which binds to EP1 receptors and activates PKC and NF-kappaB leading to NO synthesis.	Epinephrine	36-47	proline rich transmembrane protein 2	Homo sapiens	122-125
31393950-0	2019	The epinephrine-induced PGE2 reduces Na+/K+ ATPase activity in Caco-2 cells via PKC, NF-kappaB and NO.	Epinephrine	4-15	proline rich transmembrane protein 2	Homo sapiens	80-83
31393950-5	2019	Treating the cells with epinephrine or PGE2 in presence of SC19220, a blocker of EP1 receptors abolished completely the effect of the hormone and the prostaglandin while the effect was maintained unaltered in presence of antagonists to all other receptors.	Epinephrine	24-35	prostaglandin E receptor 1	Homo sapiens	81-84
29704879-8	2019	In addition, retinol reversed the epinephrine-induced increase in c-JUN protein expression, but it did not alter extracellular signal-regulated kinase 1/2 (ERK) phosphorylation in ex vivo human skin.	Epinephrine	34-45	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
31311971-0	2019	Glucose, adrenaline and palmitate antagonistically regulate insulin and glucagon secretion in human pseudoislets.	Epinephrine	9-19	insulin	Homo sapiens	60-67
31483805-3	2019	Here, we used a WKY rat model and studied the molecular changes triggered by prenatal glucocorticoid (GC) exposure on the development of hypertension, and on the regulation of phenylethanolamine N-methyl transferase (PNMT), the enzyme responsible for biosynthesis of epinephrine, and a candidate gene linked to hypertension.	Epinephrine	267-278	phenylethanolamine-N-methyltransferase	Rattus norvegicus	217-221
30991270-5	2019	The detection limits realized by the proposed sensor, under optimized analytical conditions, were found to be as low as 0.028, 0.028,0.061 and 0.029 ng mL-1 for dopamine and 0.017, 0.018, 0.019 and 0.020 ng mL-1 for epinephrine (S/N = 3) in aqueous, blood serum, urine and pharmaceutical samples.	Epinephrine	216-227	L1 cell adhesion molecule	Mus musculus	152-156
31421743-5	2019	It was observed that higher concentrations of adrenaline (1 and 10 muM) induced DNA damage in the obese, prediabetic and diabetic groups.	Epinephrine	46-56	latexin	Homo sapiens	67-70
30721673-6	2019	RESULTS: Injection of lidocaine + epinephrine (12.5 mug/ml) caused a change in the EW-DRS signal in the wavelength intervals 510 to 610 nm, known to change upon deoxygenation of hemoglobin.	Epinephrine	34-45	sushi repeat containing protein X-linked	Homo sapiens	86-89
31098664-12	2019	Logistic regression revealed hemoglobin (Hb) and fibrinogen levels at admission to be independent predictors for a decreased platelet activation in the assay with ADP (p < 0.001, Cohen"s f = 0.61) and with epinephrine (p < 0.001, f = 0.42).	Epinephrine	206-217	fibrinogen beta chain	Homo sapiens	49-59
30869808-3	2019	In the current study, we tried to pharmacologically characterize (-)-adrenaline-stimulated [35 S]GTPgammaS binding to Galphaq/11 in rat brain membranes.	Epinephrine	65-79	G protein subunit alpha q	Rattus norvegicus	118-125
30869808-5	2019	The specific [35 S]GTPgammaS binding to Galphaq/11 was stimulated by (-)-adrenaline in a concentration-dependent and saturable manner in rat cerebral cortical membranes.	Epinephrine	69-83	G protein subunit alpha q	Rattus norvegicus	40-47
31133303-9	2019	Plasma concentrations of ACTH also increased (P &lt; .01) after administration of epinephrine and prostaglandin-F2alpha in experiments 3 and 5; plasma ACTH was not measured in experiment 1 or 4 because we have previously reported that exercise and substance P stimulate plasma ACTH concentrations.	Epinephrine	82-93	pro-opiomelanocortin	Equus caballus	25-29
31934016-0	2019	Epinephrine increases malignancy of breast cancer through p38 MAPK signaling pathway in depressive disorders.	Epinephrine	0-11	mitogen-activated protein kinase 14	Homo sapiens	58-61
31934016-6	2019	Treatment of epinephrine increased the phosphorylation of p38 MAPK in cells and enhanced the growth of tumor in vivo.	Epinephrine	13-24	mitogen-activated protein kinase 14	Homo sapiens	58-61
31934016-8	2019	CONCLUSIONS: These findings suggest that activation of epinephrine-induced p38 MAPK signaling pathway enhances the malignancy of breast cancer in depressive disorders.	Epinephrine	55-66	mitogen-activated protein kinase 14	Homo sapiens	75-78
30694975-10	2019	Pretreatment of mice with propranolol attenuated the epinephrine-induced increase in FST expression.	Epinephrine	53-64	follistatin	Mus musculus	85-88
30714137-1	2019	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Epinephrine	106-116	tyrosine hydroxylase	Homo sapiens	0-20
30714137-1	2019	Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, noradrenaline and adrenaline.	Epinephrine	106-116	tyrosine hydroxylase	Homo sapiens	22-24
30694975-13	2019	CONCLUSIONS: These data suggest that both glucagon and epinephrine regulate hepatic FST expression at rest; however, only glucagon is required for the exercise-induced increase.	Epinephrine	55-66	follistatin	Mus musculus	84-87
31064696-3	2019	The aim here is to clarify that adrenaline was the first hormone, with the discovery of its activity and chemical purification being prior to secretin.	Epinephrine	32-42	secretin	Homo sapiens	142-150
29894763-2	2019	Deletion of the serotonin (5-HT) transporter (SERT) gene in mice (SERT-/- mice) or pharmacological block of SERT function in rodents and humans augments this sympathoadrenal stress response (epinephrine secretion).	Epinephrine	191-202	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	46-50
31131320-3	2019	Here, we demonstrate that l-adrenaline can act on receptor ADRA2B to inhibit the activation of the caspase-11 inflammasome by cytosolic LPS or Escherichia coli infection in macrophages.	Epinephrine	26-38	adrenergic receptor, alpha 2b	Mus musculus	59-65
31142902-4	2019	Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine.	Epinephrine	155-166	catechol-O-methyltransferase	Homo sapiens	0-28
31142902-4	2019	Catechol-O-Methyltransferase (COMT) is an enzyme in the metabolic inactivation of catecholamine and substances containing catecholamines such as dopamine, epinephrine, and norepinephrine.	Epinephrine	155-166	catechol-O-methyltransferase	Homo sapiens	30-34
30824540-4	2019	We observed that epinephrine content is reduced in the AGCCs from male Ephb6-KO mice, caused by decreased expression of tyrosine hydroxylase, the rate-limiting enzyme in CAT biosynthesis.	Epinephrine	17-28	Eph receptor B6	Mus musculus	71-76
30740755-8	2019	Moreover, olive oil was able to reverse the high epinephrine level-induced increase in extracellular signal-related kinase 1/2 (ERK 1/2) and c-JUN (a major component of transcription factor AP-1) phosphorylation and protein matrix metalloproteinase-2 (MMP-2) expression in ex vivo human skin.	Epinephrine	49-60	mitogen-activated protein kinase 3	Homo sapiens	128-135
30740755-8	2019	Moreover, olive oil was able to reverse the high epinephrine level-induced increase in extracellular signal-related kinase 1/2 (ERK 1/2) and c-JUN (a major component of transcription factor AP-1) phosphorylation and protein matrix metalloproteinase-2 (MMP-2) expression in ex vivo human skin.	Epinephrine	49-60	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	141-146
30740755-8	2019	Moreover, olive oil was able to reverse the high epinephrine level-induced increase in extracellular signal-related kinase 1/2 (ERK 1/2) and c-JUN (a major component of transcription factor AP-1) phosphorylation and protein matrix metalloproteinase-2 (MMP-2) expression in ex vivo human skin.	Epinephrine	49-60	matrix metallopeptidase 2	Homo sapiens	252-257
29995172-3	2019	Tyrosine hydroxylase (TH), tetrahydrobiopterin (BH4)-dependent and iron-containing monooxygenase, catalyzes the conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the initial and rate-limiting step in the biosynthesis of catecholamines (DA, noradrenaline, and adrenaline).	Epinephrine	269-279	tyrosine hydroxylase	Homo sapiens	0-20
29995172-3	2019	Tyrosine hydroxylase (TH), tetrahydrobiopterin (BH4)-dependent and iron-containing monooxygenase, catalyzes the conversion of L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA), which is the initial and rate-limiting step in the biosynthesis of catecholamines (DA, noradrenaline, and adrenaline).	Epinephrine	269-279	tyrosine hydroxylase	Homo sapiens	22-24
30511562-4	2019	Current neonatal resuscitation guidelines recommend administration of epinephrine once CPR has started at a dose of 0.01-0.03 mg/kg preferably given intravenously, with repeated doses every 3-5 min until return of spontaneous circulation.	Epinephrine	70-81	cytochrome p450 oxidoreductase	Homo sapiens	87-90
30963694-5	2019	Ghrelin isoforms had no independent effect on lipolysis under unstimulated conditions, but nearly completely abolished epinephrine-stimulated lipolysis.	Epinephrine	119-130	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
30937140-9	2019	Results: GLCCI1 rs37973 homozygotes mutant genotype GG had a higher plasma epinephrine concentration (median concentration 27.032 pg/ml, nGG = 36; median concentration 23.149 pg/ml, nAA+AG = 146; P = 0.015) and cortisol concentration (median concentration 1.141 ng/ml, nGG = 36; median concentration 0.921 ng/ml, nAA+AG = 146; P = 0.013).	Epinephrine	75-86	glucocorticoid induced 1	Homo sapiens	9-15
30782827-5	2019	Proteasome activities and Rpn6 phosphorylation increased similarly in working hearts upon epinephrine treatment, in skeletal muscles of exercising humans, and in electrically stimulated rat muscles.	Epinephrine	90-101	proteasome 26S subunit, non-ATPase 11	Homo sapiens	26-30
30787395-5	2019	Mechanistic analysis showed that exposure to photopic light down-regulates the expression of alpha1A-adrenoceptor (alpha1AAR) due to high levels of norepinephrine and epinephrine, subsequently suppressing inflammation.	Epinephrine	151-162	adrenoceptor alpha 1A	Homo sapiens	93-113
30787395-5	2019	Mechanistic analysis showed that exposure to photopic light down-regulates the expression of alpha1A-adrenoceptor (alpha1AAR) due to high levels of norepinephrine and epinephrine, subsequently suppressing inflammation.	Epinephrine	151-162	adrenoceptor alpha 1A	Homo sapiens	115-124
31178828-2	2019	Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP).	Epinephrine	186-197	gonadotropin releasing hormone 1	Mus musculus	71-75
31178828-2	2019	Here, I review findings from mouse studies on the direct modulation of GnRH neuron activity and GnRH secretion by non-peptide neurotransmitters (GABA, glutamate, dopamine, serotonin, norepinephrine, epinephrine, histamine, ATP, adenosine, and acetylcholine), gasotransmitters (nitric oxide and carbon monoxide), and gliotransmitters (prostaglandin E2 and possibly GABA, glutamate, and ATP).	Epinephrine	186-197	gonadotropin releasing hormone 1	Mus musculus	96-100
31131320-4	2019	l-adrenaline-induced cAMP production via the enzyme ADCY4 promotes protein kinase A (PKA) activation, which then blocks the caspase-11-mediated proteolytic maturation of interleukin-1beta, gasdermin D (GSDMD) cleavage, and consequent DAMP release.	Epinephrine	0-12	adenylate cyclase 4	Mus musculus	52-57
31131320-4	2019	l-adrenaline-induced cAMP production via the enzyme ADCY4 promotes protein kinase A (PKA) activation, which then blocks the caspase-11-mediated proteolytic maturation of interleukin-1beta, gasdermin D (GSDMD) cleavage, and consequent DAMP release.	Epinephrine	0-12	gasdermin D	Mus musculus	202-207
31083675-0	2019	Valsartan impedes epinephrine-induced ICAM-4 activation on normal, sickle cell trait and sickle cell disease red blood cells.	Epinephrine	18-29	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	38-44
31083675-2	2019	It is known that epinephrine, a beta-adrenergic receptor (beta-AR) stimulator, increases the RBC surface density of active intercellular adhesion molecule-4 (ICAM-4) which binds to the endothelial alphavbeta3.	Epinephrine	17-28	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	123-156
31083675-2	2019	It is known that epinephrine, a beta-adrenergic receptor (beta-AR) stimulator, increases the RBC surface density of active intercellular adhesion molecule-4 (ICAM-4) which binds to the endothelial alphavbeta3.	Epinephrine	17-28	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	158-164
31083675-9	2019	Importantly, we found that pretreatment of RBCs with valsartan significantly impeded the activation of ICAM-4 receptors induced by epinephrine.	Epinephrine	131-142	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	103-109
30826528-7	2019	Within groups B and C, peak cTnI correlated with duration of resuscitation, number of defibrillations and cumulative adrenaline (epinephrine) dose.	Epinephrine	117-127	troponin I3, cardiac type	Homo sapiens	28-32
30826528-7	2019	Within groups B and C, peak cTnI correlated with duration of resuscitation, number of defibrillations and cumulative adrenaline (epinephrine) dose.	Epinephrine	129-140	troponin I3, cardiac type	Homo sapiens	28-32
30821121-14	2019	BAL with the use of epinephrine diluted saline (1:10,000) effectively decreased airway mucosal bleeding.	Epinephrine	20-31	poly(ADP-ribose) polymerase family member 9	Homo sapiens	0-3
30785148-7	2019	This electrochemical sensor displayed a high selectivity owing to the specific imprinted cavities for adrenaline and worked well over a wide linear concentration range of adrenaline between 0.0015 and 50 muM with a detection limit (LOD) of 0.25 nM and good reproducibility and stability.	Epinephrine	102-112	latexin	Homo sapiens	204-207
30785148-7	2019	This electrochemical sensor displayed a high selectivity owing to the specific imprinted cavities for adrenaline and worked well over a wide linear concentration range of adrenaline between 0.0015 and 50 muM with a detection limit (LOD) of 0.25 nM and good reproducibility and stability.	Epinephrine	171-181	latexin	Homo sapiens	204-207
30782827-3	2019	Treatment of mouse hepatocytes with glucagon, epinephrine, or forskolin stimulated Rpn6 phosphorylation and the 26S proteasomes" capacity to degrade ubiquitinated proteins and peptides.	Epinephrine	46-57	proteasome 26S subunit, non-ATPase 11	Homo sapiens	83-87
30688660-0	2019	Stress-induced epinephrine enhances lactate dehydrogenase A and promotes breast cancer stem-like cells.	Epinephrine	15-26	lactate dehydrogenase A	Mus musculus	36-59
30688660-2	2019	Using an immunodeficient murine system, we showed that chronic stress-induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A-dependent (LDHA-dependent) metabolic rewiring.	Epinephrine	78-89	lactate dehydrogenase A	Mus musculus	138-161
30688660-2	2019	Using an immunodeficient murine system, we showed that chronic stress-induced epinephrine promoted breast cancer stem-like properties via lactate dehydrogenase A-dependent (LDHA-dependent) metabolic rewiring.	Epinephrine	78-89	lactate dehydrogenase A	Mus musculus	173-177
30688660-3	2019	Chronic stress-induced epinephrine activated LDHA to generate lactate, and the adjusted pH directed USP28-mediated deubiquitination and stabilization of MYC.	Epinephrine	23-34	lactate dehydrogenase A	Mus musculus	45-49
30178274-4	2019	In addition, we investigated how epinephrine regulates the synthesis of melatonin and the transcription of the key melatonin synthesis enzyme AANAT.	Epinephrine	33-44	aralkylamine N-acetyltransferase	Homo sapiens	142-147
30178274-8	2019	These results demonstrate for the first time that epinephrine can increase the synthesis of melatonin by increasing the transcription of AANAT.	Epinephrine	50-61	aralkylamine N-acetyltransferase	Homo sapiens	137-142
30503832-8	2019	RESULTS: Stimulation of epinephrine and glucagon release in response to hypoglycemia or glucopenia was diminished in both POMC- and MC4R-deficient mice, relative to their littermate controls.	Epinephrine	24-35	pro-opiomelanocortin-alpha	Mus musculus	122-126
30503832-8	2019	RESULTS: Stimulation of epinephrine and glucagon release in response to hypoglycemia or glucopenia was diminished in both POMC- and MC4R-deficient mice, relative to their littermate controls.	Epinephrine	24-35	melanocortin 4 receptor	Mus musculus	132-136
30325031-4	2019	The order of Kb values between drugs such as adrenaline hydrochloride, norepinephrine bitartrate, and propranolol hydrochloride with beta2 -AR is well consistent with that reported in the literature.	Epinephrine	45-69	adrenoceptor beta 2	Homo sapiens	133-142
30389842-11	2019	Epigenetic tuning of CAPS variants may allow modulation of endocrine adrenaline and noradrenaline release.	Epinephrine	69-79	Ca2+-dependent secretion activator	Mus musculus	21-25
30419287-1	2019	The human alpha1D-adrenergic receptor is a seven transmembrane-domain protein that mediates many of the physiological actions of adrenaline and noradrenaline and participates in the development of hypertension and benign prostatic hyperplasia.	Epinephrine	129-139	adrenoceptor alpha 1D	Homo sapiens	10-37
30388905-5	2019	Results: There were significant (P < 0.05) group by time interactions for resting epinephrine (EP) and norepinephrine (NE) levels, with EP decreasing in the TT group and NE increasing in the CON group.	Epinephrine	82-93	epiregulin	Homo sapiens	95-97
30343141-3	2019	TSPO-depleted homozygotes showed no response to adrenocorticotropic hormone (ACTH) in stimulating adrenal cortex corticosterone production but showed increased epinephrine synthesis in the medulla.	Epinephrine	160-171	translocator protein	Mus musculus	0-4
30343141-7	2019	Experimental verification of T2D symptoms via blood testing of the adult mice, including glycated hemoglobin and insulin C-peptide measurements, showed that these Tspo cKO mice exhibited sustained hyperglycemia, a sign of prediabetes, likely due to the augmentation of hepatic glucose production mediated by the increased epinephrine.	Epinephrine	322-333	translocator protein	Mus musculus	163-167
31078763-0	2019	Age-related cardiovascular outcomes in older adults receiving epinephrine for anaphylaxis in the emergency department.	Epinephrine	62-73	renin binding protein	Homo sapiens	0-3
30253326-4	2019	beta2-adrenergic receptors are much more sensitive to epinephrine than to norepinephrine.	Epinephrine	54-65	hemoglobin, beta adult minor chain	Mus musculus	0-5
29553866-13	2019	In the EA families, the burden of PEAR1 missense variants was associated with platelet aggregation after aspirin therapy when the platelets were stimulated with epinephrine (p = 0.0009) and collagen (p = 0.03).	Epinephrine	161-172	platelet endothelial aggregation receptor 1	Homo sapiens	34-39
29553866-14	2019	In AAs, the burden of PEAR1 missense variants was associated, to a lesser degree, with platelet aggregation in response to epinephrine (p = 0.02) and ADP (p = 0.04).	Epinephrine	123-134	platelet endothelial aggregation receptor 1	Homo sapiens	22-27
30619611-1	2019	alpha1A- and alpha1B-adrenoceptors (ARs) are G protein-coupled receptors (GPCRs) that are activated by adrenaline and noradrenaline to modulate smooth muscle contraction in the periphery, and neuronal outputs in the central nervous system (CNS).	Epinephrine	103-113	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	0-7
30226996-7	2018	Separate experiments in nondiabetic rats in which GLUT4 translocation into the VMH was inhibited with an infusion of indinavir were notable for an impaired CRR to hypoglycemia, indicated by increased glucose infusion rate and diminished epinephrine and glucagon responses.	Epinephrine	237-248	solute carrier family 2 member 4	Rattus norvegicus	50-55
30232658-0	2018	Publisher Correction: Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest: Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated the Vasopressin-Steroids-Epinephrine Combination Versus Epinephrine Alone.	Epinephrine	228-239	arginine vasopressin	Homo sapiens	207-218
30232658-0	2018	Publisher Correction: Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest: Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated the Vasopressin-Steroids-Epinephrine Combination Versus Epinephrine Alone.	Epinephrine	259-270	arginine vasopressin	Homo sapiens	207-218
30177026-3	2018	OBJECTIVE: This study examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).	Epinephrine	46-49	transcription factor 7 like 2	Homo sapiens	97-103
30316293-11	2018	Epinephrine and myricetin, which target FEN1, have shown cytotoxic effect on Mero-14 cells whereas marimastat and batimastat, which target MMP2 demonstrated a modest but significant inhibitory effect on MPM cell migration.	Epinephrine	0-11	flap structure-specific endonuclease 1	Homo sapiens	40-44
30234204-1	2018	The intrinsic structure of an opioid peptide [Ala2, Leu5]-leucine enkephalin (ALE) has been investigated using first-principles based vibrational self-consistent field (VSCF) theory and cold ion spectroscopy.	Epinephrine	78-81	tripartite motif containing 13	Homo sapiens	52-56
30106614-8	2018	Excluding the groups with errors, the mean time to administration of IM epinephrine was 97 seconds with versus 152 seconds without the visual aid (p = 0.04).	Epinephrine	72-83	activation induced cytidine deaminase	Homo sapiens	142-145
30106614-10	2018	CONCLUSION: A visual aid increased the subjective confidence of radiologists in the dose and route of medication administration in the contrast medium reaction simulation and led to faster administration of epinephrine.	Epinephrine	207-218	activation induced cytidine deaminase	Homo sapiens	21-24
30119168-7	2018	ALE pretreatment, however, significantly attenuated these excitotoxicity-related features according to the results of Annexin V analysis and the lactate dehydrogenase assay, in which the calpain pathway (in a caspase 3-independent manner) may be involved.	Epinephrine	0-3	annexin A5	Mus musculus	118-127
30119168-7	2018	ALE pretreatment, however, significantly attenuated these excitotoxicity-related features according to the results of Annexin V analysis and the lactate dehydrogenase assay, in which the calpain pathway (in a caspase 3-independent manner) may be involved.	Epinephrine	0-3	caspase 3	Mus musculus	209-218
30119168-8	2018	ALE pretreatment also significantly attenuated the glutamate-induced activation of both inflammation-associated molecules (extracellular signal-regulated kinase, c-Jun N-terminal kinases and p38) and death-related molecules (p53, apoptosis-inducing factor).	Epinephrine	0-3	jun proto-oncogene	Mus musculus	162-167
30119168-8	2018	ALE pretreatment also significantly attenuated the glutamate-induced activation of both inflammation-associated molecules (extracellular signal-regulated kinase, c-Jun N-terminal kinases and p38) and death-related molecules (p53, apoptosis-inducing factor).	Epinephrine	0-3	mitogen-activated protein kinase 14	Mus musculus	191-194
30119168-8	2018	ALE pretreatment also significantly attenuated the glutamate-induced activation of both inflammation-associated molecules (extracellular signal-regulated kinase, c-Jun N-terminal kinases and p38) and death-related molecules (p53, apoptosis-inducing factor).	Epinephrine	0-3	transformation related protein 53, pseudogene	Mus musculus	225-228
30119168-9	2018	The inactivation of brain-derived neurotrophic factor (BDNF) was restored by ALE pretreatment.	Epinephrine	77-80	brain derived neurotrophic factor	Mus musculus	20-53
30119168-9	2018	The inactivation of brain-derived neurotrophic factor (BDNF) was restored by ALE pretreatment.	Epinephrine	77-80	brain derived neurotrophic factor	Mus musculus	55-59
29482394-5	2018	The most potent compound 3, effectively inhibited the platelet-aggregation induced both by collagen and ADP/adrenaline with IC50 of 26.9 muM and 20.5 muM respectively.	Epinephrine	108-118	latexin	Homo sapiens	137-140
29482394-5	2018	The most potent compound 3, effectively inhibited the platelet-aggregation induced both by collagen and ADP/adrenaline with IC50 of 26.9 muM and 20.5 muM respectively.	Epinephrine	108-118	latexin	Homo sapiens	150-153
30584458-5	2018	The obtained results revealed that all doses of adrenaline induced a significant rise in CAT activity, MDA level, PCC, NO2 -, and 3-NT and a significant decrease in SOD activity compared to control.	Epinephrine	48-58	catalase	Rattus norvegicus	89-92
30584458-6	2018	Adrenaline exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes.	Epinephrine	0-10	lactate dehydrogenase A	Rattus norvegicus	57-61
30584458-6	2018	Adrenaline exerted an increase in total activity of LDH, LDH1, and LDH2 isoenzymes.	Epinephrine	0-10	lactate dehydrogenase B	Rattus norvegicus	67-71
30341696-1	2018	In early 1920s, tyramine oxidase was discovered that metabolized tyramine and in 1933 Blaschko demonstrated that this enzyme also metabolized adrenaline, noradrenaline and dopamine.	Epinephrine	142-152	monoamine oxidase B	Homo sapiens	16-32
30146176-11	2018	For epinephrine, we found increased responses in GCK-MODY patients, in beta-cell ablated diabetic I366F mice and in conditional (nestin lineage) brain glucokinase-knockout mice, supporting a role for brain glucokinase in triggering epinephrine release.	Epinephrine	4-15	glucokinase	Homo sapiens	49-52
30327561-5	2018	A structural comparison with the beta2AR bound to the full agonist epinephrine reveals differences in the hydrogen-bond network involving residues Ser2045.43 and Asn2936.55.	Epinephrine	67-78	adrenoceptor beta 2	Homo sapiens	33-40
30196147-9	2018	P2X3 shRNA also reduced the incremental concentration of serum epinephrine and the phosphorylation level of extracellular regulated protein kinases1/2 in diabetic rats.	Epinephrine	63-74	purinergic receptor P2X 3	Rattus norvegicus	0-4
30349891-8	2018	Adrenaline also increased ADP-induced platelet activation: from 40% (36-54%) to 83% (74-88%) platelets with active fibrinogen receptor (binding PAC-1) and from 13% (7-21%) to 35% (18-50%) P-selectin-expressing platelets.	Epinephrine	0-10	ADCYAP receptor type I	Homo sapiens	144-149
30349891-8	2018	Adrenaline also increased ADP-induced platelet activation: from 40% (36-54%) to 83% (74-88%) platelets with active fibrinogen receptor (binding PAC-1) and from 13% (7-21%) to 35% (18-50%) P-selectin-expressing platelets.	Epinephrine	0-10	selectin P	Homo sapiens	188-198
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	160-173
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	C-X-C motif chemokine ligand 8	Homo sapiens	175-179
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	mitogen-activated protein kinase 1	Homo sapiens	294-297
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	mitogen-activated protein kinase 8	Homo sapiens	300-324
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	mitogen-activated protein kinase 8	Homo sapiens	326-329
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	mitogen-activated protein kinase 1	Homo sapiens	336-339
30254686-7	2018	As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs).	Epinephrine	13-16	mitogen-activated protein kinase 1	Homo sapiens	239-243
30177026-8	2018	RESULTS: ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P &lt; 0.05).	Epinephrine	9-12	insulin	Homo sapiens	39-46
30177026-8	2018	RESULTS: ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P &lt; 0.05).	Epinephrine	9-12	insulin	Homo sapiens	93-100
30177026-8	2018	RESULTS: ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P &lt; 0.05).	Epinephrine	9-12	transcription factor 7 like 2	Homo sapiens	158-164
30177026-10	2018	CONCLUSION: The responses of insulin and HOMA-IR to ALE supplementation have shown an interaction with single-nucleotide polymorphism rs7903146 in TCF7L2.	Epinephrine	52-55	insulin	Homo sapiens	29-36
30177026-10	2018	CONCLUSION: The responses of insulin and HOMA-IR to ALE supplementation have shown an interaction with single-nucleotide polymorphism rs7903146 in TCF7L2.	Epinephrine	52-55	transcription factor 7 like 2	Homo sapiens	147-153
30125310-6	2018	Plasma norepinephrine and epinephrine concentrations were significantly higher in patients with oral and oropharyngeal squamous cell carcinoma (SCC) compared to non-cancer patients.	Epinephrine	10-21	serpin family B member 3	Homo sapiens	144-147
29678603-4	2018	In this study we evaluated the alcoholic extract of triphala (AlE) and its compounds Chebulagic acid (CA), Chebulinic acid (CI) and Gallic acid (GA) for their anti-TNFalpha activity.	Epinephrine	62-65	tumor necrosis factor	Mus musculus	164-172
29678603-8	2018	Ex vivo angiogenesis assay using chick chorioallantoic membrane (CAM) model also showed that TNFalpha-induced angiogenesis and it was inhibited by AlE and its active principles.	Epinephrine	147-150	lipopolysaccharide induced TNF factor	Gallus gallus	93-101
30080180-3	2018	demonstrate that neuropeptide Y (NPY) secretion from adrenal chromaffin cells persists during exposure to recurrent hypoglycemia and activation of the sympathetic nerves at the same time that epinephrine secretion is reduced.	Epinephrine	192-203	neuropeptide Y	Homo sapiens	17-31
30080180-3	2018	demonstrate that neuropeptide Y (NPY) secretion from adrenal chromaffin cells persists during exposure to recurrent hypoglycemia and activation of the sympathetic nerves at the same time that epinephrine secretion is reduced.	Epinephrine	192-203	neuropeptide Y	Homo sapiens	33-36
30080182-8	2018	Inhibition of NPY or Y1 signaling, either transgenically or pharmacologically, prevented the attenuation of both TH expression and epinephrine release.	Epinephrine	131-142	neuropeptide Y	Mus musculus	14-17
30125310-8	2018	Plasma epinephrine levels in oral SCC patients were higher compared to the oropharyngeal SCC (p = .0097) and leukoplakia (p &lt; .0001) patients.	Epinephrine	7-18	serpin family B member 3	Homo sapiens	34-37
30125310-9	2018	Oropharyngeal SCC patients had higher plasma norepinephrine (p = .0382) and epinephrine levels (p = .045) than patients with oral leukoplakia.	Epinephrine	48-59	serpin family B member 3	Homo sapiens	14-17
30125310-11	2018	Anxiety symptom of "hand tremor" measured by the BAI was an independent predictor for higher plasma norepinephrine levels in HNSCC patients (beta = 157.5, p = .0377), while the "heart pounding/racing" symptom was independently associated with higher plasma epinephrine levels in the oropharyngeal SCC group (beta = 15.8, p = .0441).	Epinephrine	103-114	serpin family B member 3	Homo sapiens	127-130
29753967-6	2018	By taking advantage of this fact, a sensitive probe was designed for determination of dopamine, adrenaline and noradrenaline with a limit of detection of 0.07, 0.60 and 0.01 muM, respectively.	Epinephrine	96-106	latexin	Homo sapiens	174-177
30210708-7	2018	Platelet membrane expression of P-selectin was measured by flow cytometry with either ADP alone or combined with epinephrine.	Epinephrine	113-124	selectin P	Homo sapiens	32-42
30210708-8	2018	RESULTS: Epinephrine at low dose stimulated ADP-induced platelet membrane expression of CD62P whereas Atipamezole significantly inhibited 10 microM ADP-induced platelet aggregation.	Epinephrine	9-20	selectin P	Homo sapiens	88-93
29738736-4	2018	One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine.	Epinephrine	232-243	OCTN3	Homo sapiens	146-174
30070610-6	2018	In a separate series of experiments, we show that insulin stimulates ULK1 phosphorylation at Ser757 (inhibitory site) in both hypoglycemic and euglycemic conditions, suggesting that counter-regulatory hormones (such as epinephrine, norepinephrine, growth hormone and glucagon) have limited effects on autophagy signaling in human skeletal muscle.	Epinephrine	219-230	insulin	Homo sapiens	50-57
30070610-6	2018	In a separate series of experiments, we show that insulin stimulates ULK1 phosphorylation at Ser757 (inhibitory site) in both hypoglycemic and euglycemic conditions, suggesting that counter-regulatory hormones (such as epinephrine, norepinephrine, growth hormone and glucagon) have limited effects on autophagy signaling in human skeletal muscle.	Epinephrine	219-230	unc-51 like autophagy activating kinase 1	Homo sapiens	69-73
30120664-1	2018	We studied the effect of collagen fragments (PGP and AcPGP) on serum content of epinephrine, corticosterone, and IL-1beta in rats subjected to water-immersion stress.	Epinephrine	80-91	phosphoglycolate phosphatase	Rattus norvegicus	45-48
30084038-0	2018	Exposure to Stress-Dose Steroids and Lethal Septic Shock After In-Hospital Cardiac Arrest: Individual Patient Data Reanalysis of Two Prior Randomized Clinical Trials that Evaluated the Vasopressin-Steroids-Epinephrine Combination Versus Epinephrine Alone.	Epinephrine	206-217	arginine vasopressin	Homo sapiens	185-196
29738736-4	2018	One such GR-independent mechanism involves corticosteroid-induced inhibition of monoamine transport mediated by "uptake2" transporters, including organic cation transporter 3 (OCT3), a low-affinity, high-capacity transporter for norepinephrine, epinephrine, dopamine, serotonin and histamine.	Epinephrine	232-243	OCTN3	Homo sapiens	176-180
29663060-4	2018	Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone.	Epinephrine	30-40	tyrosinase	Homo sapiens	0-10
29979696-9	2018	Plasma adrenaline levels were shown to be associated with plasma ACTH levels in HCs injected with CRH during distention using structural equation modeling analysis.	Epinephrine	7-17	proopiomelanocortin	Homo sapiens	65-69
29979696-9	2018	Plasma adrenaline levels were shown to be associated with plasma ACTH levels in HCs injected with CRH during distention using structural equation modeling analysis.	Epinephrine	7-17	corticotropin releasing hormone	Homo sapiens	98-101
29663060-4	2018	Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone.	Epinephrine	30-40	tyrosinase	Homo sapiens	12-15
29663060-4	2018	Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone.	Epinephrine	88-98	tyrosinase	Homo sapiens	0-10
29663060-4	2018	Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone.	Epinephrine	88-98	tyrosinase	Homo sapiens	12-15
29663060-4	2018	Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone.	Epinephrine	88-98	tyrosinase	Homo sapiens	0-10
29663060-4	2018	Tyrosinase (TYR) can catalyze adrenaline to generate H2O2, and additionally oxidize the adrenaline to adrenaline quinone.	Epinephrine	88-98	tyrosinase	Homo sapiens	12-15
29663060-7	2018	Under the optimum conditions, the fluorescence quenching ratio If/If0 (If and If0 were the fluorescence intensity of Adr-CuInS2 QDs in the presence and absence of TYR, respectively) was proportional to the logarithm of adrenaline concentration in the range of 1 x 10-8-1 x 10-4 mol L-1 with the detection limit of 3.6 nmol L-1.	Epinephrine	219-229	tyrosinase	Homo sapiens	163-166
28540658-6	2018	DYRK1A overexpression induced dramatic deficits in the serotonin contents of the four brain areas tested and major deficits in dopamine and adrenaline contents especially in the hypothalamus.	Epinephrine	140-150	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	Mus musculus	0-6
29377263-4	2018	In the present study, we investigated the effects of adrenaline (AD) and norepinephrine (NE) on hepatic hepcidin regulation.	Epinephrine	65-67	hepcidin antimicrobial peptide	Mus musculus	104-112
29520889-7	2018	ALE treatment compared with placebo: Doppler sonography showed increased hepatic vein flow (p &lt; .001), reduced portal vein diameter (p &lt; .001) and liver size (p &lt; .001), reduction in serum ALT (p &lt; .001) and AST (p &lt; .001) levels, improvement in AST/ALT ratio and APRI scores (p &lt; .01), and reduction in total bilirubin.	Epinephrine	0-3	solute carrier family 17 member 5	Homo sapiens	220-223
29520889-7	2018	ALE treatment compared with placebo: Doppler sonography showed increased hepatic vein flow (p &lt; .001), reduced portal vein diameter (p &lt; .001) and liver size (p &lt; .001), reduction in serum ALT (p &lt; .001) and AST (p &lt; .001) levels, improvement in AST/ALT ratio and APRI scores (p &lt; .01), and reduction in total bilirubin.	Epinephrine	0-3	solute carrier family 17 member 5	Homo sapiens	261-264
29520889-9	2018	This study has shown beneficial effects of ALE supplementation on both ultrasound liver parameters and liver serum parameters (ALT, AST, APRI ratio, and total bilirubin) in patients with NAFLD.	Epinephrine	43-46	solute carrier family 17 member 5	Homo sapiens	132-135
29563152-0	2018	Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca2+ Mobilization From Acidic Stores in Pancreatic alpha-Cells.	Epinephrine	0-10	two pore segment channel 2	Homo sapiens	44-48
29563152-6	2018	Genetic or pharmacological inhibition of the Tpc2 channel (that mediates Ca2+ release from acidic intracellular stores) abolished the stimulatory effect of adrenaline on glucagon secretion and reduced the elevation of [Ca2+]i Furthermore, in Tpc2-deficient islets, ryanodine exerted no additive inhibitory effect.	Epinephrine	156-166	two pore segment channel 2	Homo sapiens	45-49
29563152-6	2018	Genetic or pharmacological inhibition of the Tpc2 channel (that mediates Ca2+ release from acidic intracellular stores) abolished the stimulatory effect of adrenaline on glucagon secretion and reduced the elevation of [Ca2+]i Furthermore, in Tpc2-deficient islets, ryanodine exerted no additive inhibitory effect.	Epinephrine	156-166	two pore segment channel 2	Homo sapiens	242-246
29575487-15	2018	Furthermore, in vivo inhibition or genetic ablation of PDK1 protected mice from collagen/epinephrine-induced pulmonary embolism.	Epinephrine	89-100	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	55-59
29851841-1	2018	RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor.	Epinephrine	285-296	dopa decarboxylase	Homo sapiens	24-50
29851841-1	2018	RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor.	Epinephrine	285-296	dopa decarboxylase	Homo sapiens	52-56
29851841-1	2018	RATIONALE: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by a deficit of the AADC that is involved in serotonin and dopamine biosynthesis, causing as a consequence, their deficits, but also a lack of norepinephrine and epinephrine, given that dopamine is their precursor.	Epinephrine	285-296	dopa decarboxylase	Homo sapiens	70-74
29377263-0	2018	The alpha1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway.	Epinephrine	79-89	hepcidin antimicrobial peptide	Mus musculus	46-54
29377263-0	2018	The alpha1-adrenergic receptor is involved in hepcidin upregulation induced by adrenaline and norepinephrine via the STAT3 pathway.	Epinephrine	79-89	signal transducer and activator of transcription 3	Mus musculus	117-122
29377263-4	2018	In the present study, we investigated the effects of adrenaline (AD) and norepinephrine (NE) on hepatic hepcidin regulation.	Epinephrine	53-63	hepcidin antimicrobial peptide	Mus musculus	104-112
29499559-0	2018	Electron beam-irradiated polypyrrole decorated with Bovine serum albumin pores: Simultaneous determination of epinephrine and L-tyrosine.	Epinephrine	110-121	albumin	Gallus gallus	59-72
29499559-1	2018	In current work highly sensitive and stable electrochemical sensor for simultaneous non-enzymatic detection of epinephrine (EP), L-tyrosine (L-Tyr) is constructed based on Electron beam irradiated Polypyrrole (EB-Ppy) nanospheres (Zeta potential 33.69 mV at pH 7) embedded over bovine serum albumin (BSA) (Zeta potential - 11.54 mV at pH 7) porous structure, fabricated by simple chemical routes.	Epinephrine	111-122	albumin	Gallus gallus	285-298
29499559-1	2018	In current work highly sensitive and stable electrochemical sensor for simultaneous non-enzymatic detection of epinephrine (EP), L-tyrosine (L-Tyr) is constructed based on Electron beam irradiated Polypyrrole (EB-Ppy) nanospheres (Zeta potential 33.69 mV at pH 7) embedded over bovine serum albumin (BSA) (Zeta potential - 11.54 mV at pH 7) porous structure, fabricated by simple chemical routes.	Epinephrine	124-126	albumin	Gallus gallus	285-298
29686017-7	2018	Moreover, in human and rat neurons, we identified the presence of the epinephrine-synthesizing enzyme PNMT (phenylethanolamine-N-methyltransferase).	Epinephrine	70-81	phenylethanolamine-N-methyltransferase	Rattus norvegicus	102-106
29686017-7	2018	Moreover, in human and rat neurons, we identified the presence of the epinephrine-synthesizing enzyme PNMT (phenylethanolamine-N-methyltransferase).	Epinephrine	70-81	phenylethanolamine-N-methyltransferase	Rattus norvegicus	108-146
29524394-2	2018	The current study aimed to clarify the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the enzymatic characteristics of the sulfation of dopamine, epinephrine, norepinephrine and serotonin by SULT1A3 allozymes.	Epinephrine	187-198	sulfotransferase family 1A member 3	Homo sapiens	98-105
29524394-2	2018	The current study aimed to clarify the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the enzymatic characteristics of the sulfation of dopamine, epinephrine, norepinephrine and serotonin by SULT1A3 allozymes.	Epinephrine	187-198	sulfotransferase family 1A member 4	Homo sapiens	110-117
29704250-9	2018	Using this system with a gold microelectrode, dopamine, and epinephrine could be quantified within the concentration range of 1-500 muM and detected at a concentration of 0.3 muM.	Epinephrine	60-71	latexin	Homo sapiens	132-135
28406726-1	2018	Mechanisms of platelet activation are triggered by thrombin, adenosine diphosphate (ADP), epinephrine, thromboxane A2, and other soluble agonists which induce signaling via heterotrimeric Galphaq, Galphai, and Galpha12/13 proteins.	Epinephrine	90-101	G protein subunit alpha q	Homo sapiens	188-195
29704250-9	2018	Using this system with a gold microelectrode, dopamine, and epinephrine could be quantified within the concentration range of 1-500 muM and detected at a concentration of 0.3 muM.	Epinephrine	60-71	latexin	Homo sapiens	175-178
29373090-6	2018	Similar to what has been observed in a thermal burn injury, the enzyme phenylethanolamine N-methyltransferase (PNMT), which generates epinephrine, was elevated in the combined thermal burn and radiation wounds.	Epinephrine	134-145	phenylethanolamine N-methyltransferase	Homo sapiens	71-109
29166705-6	2018	The system allowed a limit of detection between 0.625 and 2.5 pg muL-1 for monoamine analytes and their metabolites, including dopamine, 3,4-dihydroxyphenylacetic acid, 3-methoxytyramine, homovanillic acid, norepinephrine, epinephrine, 3-methoxy-4-hydroxyphenylglycol, serotonin and 5-hydroxyindoleacetic acid.	Epinephrine	210-221	mitochondrial ubiquitin ligase activator of NFKB 1	Mus musculus	65-70
29373090-6	2018	Similar to what has been observed in a thermal burn injury, the enzyme phenylethanolamine N-methyltransferase (PNMT), which generates epinephrine, was elevated in the combined thermal burn and radiation wounds.	Epinephrine	134-145	phenylethanolamine N-methyltransferase	Homo sapiens	111-115
29572320-11	2018	Myocardial beta1-adrenoceptor expression decreased with normothermia cardiac arrest but not with hypothermia regardless of epinephrine.	Epinephrine	123-134	adrenoceptor beta 1	Rattus norvegicus	11-29
29554700-10	2018	An alternative method of platelet activation using platelet agonists 20 microM ADP or 10 microM epinephrine also increased CD62P+ EV levels, and this too was attenuated by prior incubation with colchicine.	Epinephrine	96-107	selectin P	Homo sapiens	123-128
29593559-8	2018	Ghrelin partially attenuated the CPB-induced elevation of epinephrine and to a lesser extent norepinephrine when compared to the CPB saline group, while dopamine levels were completely suppressed.	Epinephrine	58-69	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
29233027-3	2018	The study aimed to examine the possible cardioprotective effect of members of phosphodiesterase type 5 (PDE-5) inhibitors in epinephrine-induced arrhythmia in rats.	Epinephrine	125-136	phosphodiesterase 5A	Rattus norvegicus	78-102
29233027-3	2018	The study aimed to examine the possible cardioprotective effect of members of phosphodiesterase type 5 (PDE-5) inhibitors in epinephrine-induced arrhythmia in rats.	Epinephrine	125-136	phosphodiesterase 5A	Rattus norvegicus	104-109
29233027-12	2018	While pretreatment of rats with PDE-5 inhibitors improved GSH and adiponectin contents, ameliorated serum MDA and NO levels and heart LDH and CK contents and corrected epinephrine-induced histopathological changes.	Epinephrine	168-179	phosphodiesterase 5A	Rattus norvegicus	32-37
29233027-13	2018	PDE-5 inhibitors may delay epinephrine-induced arrhythmia through expression of adiponectin and downregulation of heart LDH and CK.	Epinephrine	27-38	phosphodiesterase 5A	Rattus norvegicus	0-5
29233027-13	2018	PDE-5 inhibitors may delay epinephrine-induced arrhythmia through expression of adiponectin and downregulation of heart LDH and CK.	Epinephrine	27-38	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	80-91
29233027-10	2018	Epinephrine group had lower serum reduced glutathione (GSH) and adiponectin levels and higher serum malondialdehyde (MDA), nitric oxide (NO), heart LDH, and CK contents.	Epinephrine	0-11	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	64-75
29466417-0	2018	Epinephrine modulates Na+/K+ ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2.	Epinephrine	0-11	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	65-68
29802722-12	2018	ALE promoted tube formation in vitro and induced intense angiogenesis in M-DAT in vivo; furthermore, higher expression of the adipogenic factor PPARgamma and greater numbers of adipocytes were evident following ALE treatment, compared with those in the M-DAT group.	Epinephrine	0-3	solute carrier family 6 member 3	Homo sapiens	75-78
29802722-12	2018	ALE promoted tube formation in vitro and induced intense angiogenesis in M-DAT in vivo; furthermore, higher expression of the adipogenic factor PPARgamma and greater numbers of adipocytes were evident following ALE treatment, compared with those in the M-DAT group.	Epinephrine	0-3	solute carrier family 6 member 3	Homo sapiens	73-78
29802722-12	2018	ALE promoted tube formation in vitro and induced intense angiogenesis in M-DAT in vivo; furthermore, higher expression of the adipogenic factor PPARgamma and greater numbers of adipocytes were evident following ALE treatment, compared with those in the M-DAT group.	Epinephrine	211-214	peroxisome proliferator activated receptor gamma	Homo sapiens	144-153
29466417-10	2018	Treatment with indomethacin, PP2, SB202190, and PD98059, respective inhibitors of COX enzymes, Src, p38MAPK, and ERK completely abrogated the effect of epinephrine.	Epinephrine	152-163	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	29-32
29466417-0	2018	Epinephrine modulates Na+/K+ ATPase activity in Caco-2 cells via Src, p38MAPK, ERK and PGE2.	Epinephrine	0-11	mitogen-activated protein kinase 1	Homo sapiens	79-82
29466417-10	2018	Treatment with indomethacin, PP2, SB202190, and PD98059, respective inhibitors of COX enzymes, Src, p38MAPK, and ERK completely abrogated the effect of epinephrine.	Epinephrine	152-163	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	95-98
29466417-10	2018	Treatment with indomethacin, PP2, SB202190, and PD98059, respective inhibitors of COX enzymes, Src, p38MAPK, and ERK completely abrogated the effect of epinephrine.	Epinephrine	152-163	mitogen-activated protein kinase 1	Homo sapiens	113-116
29306449-1	2018	Adrenaline-deficient phenylethanolamine-N-methyltransferase-knockout mice (Pnmt-KO) have concentric heart remodeling and though their resting blood pressure is normal, it becomes higher during acute exercise.	Epinephrine	0-10	phenylethanolamine-N-methyltransferase	Mus musculus	21-59
29466417-12	2018	Western blot analysis revealed an epinephrine-induced increase in the phosphorylation of p38 MAPK and ERK that disappeared in presence of respectively PP2 and SB2020190.	Epinephrine	34-45	mitogen-activated protein kinase 14	Homo sapiens	89-92
29466417-12	2018	Western blot analysis revealed an epinephrine-induced increase in the phosphorylation of p38 MAPK and ERK that disappeared in presence of respectively PP2 and SB2020190.	Epinephrine	34-45	mitogen-activated protein kinase 1	Homo sapiens	93-97
29466417-12	2018	Western blot analysis revealed an epinephrine-induced increase in the phosphorylation of p38 MAPK and ERK that disappeared in presence of respectively PP2 and SB2020190.	Epinephrine	34-45	mitogen-activated protein kinase 1	Homo sapiens	102-105
29466417-12	2018	Western blot analysis revealed an epinephrine-induced increase in the phosphorylation of p38 MAPK and ERK that disappeared in presence of respectively PP2 and SB2020190.	Epinephrine	34-45	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	151-154
29466417-14	2018	It was concluded that epinephrine inhibits the Na+/K+-ATPase by the sequential activation of alpha2 adrenergic receptors, Src, p38MAPK, and ERK leading to PGE2 release.	Epinephrine	22-33	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	122-125
29466417-14	2018	It was concluded that epinephrine inhibits the Na+/K+-ATPase by the sequential activation of alpha2 adrenergic receptors, Src, p38MAPK, and ERK leading to PGE2 release.	Epinephrine	22-33	mitogen-activated protein kinase 1	Homo sapiens	140-143
29306449-1	2018	Adrenaline-deficient phenylethanolamine-N-methyltransferase-knockout mice (Pnmt-KO) have concentric heart remodeling and though their resting blood pressure is normal, it becomes higher during acute exercise.	Epinephrine	0-10	phenylethanolamine-N-methyltransferase	Mus musculus	75-79
29472863-6	2018	The selective beta2-adrenergic receptor antagonist ICI-118,551 (300 nM) resulted in a rightward shift of the epinephrine concentration-response relationship.	Epinephrine	109-120	adrenoceptor beta 2	Rattus norvegicus	14-39
29288726-5	2018	PNMT, the terminal enzyme in the catecholamine biosynthetic pathway, directly responsible for adrenaline synthesis, is elevated in hypertensive animals.	Epinephrine	94-104	phenylethanolamine N-methyltransferase	Homo sapiens	0-4
29208598-3	2018	Downregulation of myosin IIa by shRNAs significantly suppressed both forskolin- and epinephrine-induced VWF secretion.	Epinephrine	84-95	myosin, heavy polypeptide 9, non-muscle	Mus musculus	18-28
29208598-3	2018	Downregulation of myosin IIa by shRNAs significantly suppressed both forskolin- and epinephrine-induced VWF secretion.	Epinephrine	84-95	Von Willebrand factor	Mus musculus	104-107
29208598-4	2018	Endothelium-specific myosin IIa knockout mice exhibited impaired epinephrine-stimulated VWF release, prolonged bleeding time, and thrombosis.	Epinephrine	65-76	myosin, heavy polypeptide 9, non-muscle	Mus musculus	21-31
29208598-4	2018	Endothelium-specific myosin IIa knockout mice exhibited impaired epinephrine-stimulated VWF release, prolonged bleeding time, and thrombosis.	Epinephrine	65-76	Von Willebrand factor	Mus musculus	88-91
29339804-0	2018	EPHB6 and testosterone in concert regulate epinephrine release by adrenal gland chromaffin cells.	Epinephrine	43-54	Eph receptor B6	Mus musculus	0-5
29386559-5	2018	Here we show that the adrenergic hormones epinephrine and norepinephrine induce PRL expression in the human monocytic cell line THP-1 at physiological concentrations.	Epinephrine	42-53	prolactin	Homo sapiens	80-83
29246838-12	2018	When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place.	Epinephrine	107-117	tyrosine hydroxylase	Rattus norvegicus	184-186
29246838-12	2018	When the chromaffin cells were treated with nicotine in the presence of the insecticide, nicotine-elevated adrenaline production was enhanced due to facilitation of nicotine-increased TH and PNMT protein expression, and simultaneous enhancement of nicotine-elevated adrenaline secretion also took place.	Epinephrine	107-117	phenylethanolamine-N-methyltransferase	Rattus norvegicus	191-195
29763913-10	2018	Interestingly, LKB1 over-expression in the hypothalamus activated the AMPK-POMC neurons-sympathetic nervous system (SNS) axis, which can release epinephrine to promote white fat browning.	Epinephrine	145-156	serine/threonine kinase 11	Rattus norvegicus	15-19
29233551-3	2018	We showed that continuing BMP4 and curtailing FGF2 in vitro, augmented with corticosteroid mimetic, induced these cells to upregulate the chromaffin cell-specific marker PNMT and other CA synthesis and storage markers, and we demonstrated noradrenaline and adrenaline by Faglu and high-performance liquid chromatography.	Epinephrine	242-252	bone morphogenetic protein 4	Homo sapiens	26-30
29233551-3	2018	We showed that continuing BMP4 and curtailing FGF2 in vitro, augmented with corticosteroid mimetic, induced these cells to upregulate the chromaffin cell-specific marker PNMT and other CA synthesis and storage markers, and we demonstrated noradrenaline and adrenaline by Faglu and high-performance liquid chromatography.	Epinephrine	242-252	fibroblast growth factor 2	Homo sapiens	46-50
29178678-9	2018	CONCLUSIONS: Blockade of beta2-adrenoceptor can deteriorate systemic anaphylaxis by augmenting hyperpermeability-induced increase in plasma extravasation by inhibiting beneficial effects of epinephrine released from the adrenal glands in anesthetized mice.	Epinephrine	190-201	adrenergic receptor, beta 2	Mus musculus	25-43
29111111-2	2018	Serotonin (5-HT) and adrenaline acting at platelet 5-HT2A-serotoninergic and alpha2-adrenergic receptors are involved in platelet aggregation.	Epinephrine	21-31	5-hydroxytryptamine receptor 2A	Rattus norvegicus	51-57
29763913-10	2018	Interestingly, LKB1 over-expression in the hypothalamus activated the AMPK-POMC neurons-sympathetic nervous system (SNS) axis, which can release epinephrine to promote white fat browning.	Epinephrine	145-156	proopiomelanocortin	Rattus norvegicus	75-79
29455206-8	2018	RESULTS: Epinephrine increases MKP-1 transcripts and protein and decreases LPS-induced p38 and JNK phosphorylation and TNF-alpha gene transcription.	Epinephrine	9-20	dual specificity phosphatase 1	Homo sapiens	31-36
30303416-13	2018	These findings suggest that the observed rise in IL-6 during hyperthermia is mediated, at least in part, by plasma adrenaline.	Epinephrine	115-125	interleukin 6	Homo sapiens	49-53
29455206-8	2018	RESULTS: Epinephrine increases MKP-1 transcripts and protein and decreases LPS-induced p38 and JNK phosphorylation and TNF-alpha gene transcription.	Epinephrine	9-20	mitogen-activated protein kinase 14	Homo sapiens	87-90
29455206-8	2018	RESULTS: Epinephrine increases MKP-1 transcripts and protein and decreases LPS-induced p38 and JNK phosphorylation and TNF-alpha gene transcription.	Epinephrine	9-20	mitogen-activated protein kinase 8	Homo sapiens	95-98
29455206-8	2018	RESULTS: Epinephrine increases MKP-1 transcripts and protein and decreases LPS-induced p38 and JNK phosphorylation and TNF-alpha gene transcription.	Epinephrine	9-20	tumor necrosis factor	Homo sapiens	119-128
29308764-3	2018	The hypothalamus-pituitary-adrenal cortical (HPA) axis and sympathetic-adrenal medulla axis were activated and participated the initiation and progression of the stress response through the production of adrenocorticotropic hormone (ACTH), glucocorticoid (GC), epinephrine and norepinephrine (NE).	Epinephrine	261-272	proopiomelanocortin	Homo sapiens	204-231
29040203-7	2018	METHODS: Confluent human umbilical vein endothelial cells (HUVEC) were exposed to hydrogen peroxide and/or epinephrine (EPI) to stimulate postshock reperfusion.	Epinephrine	107-118	tissue factor pathway inhibitor	Homo sapiens	120-123
30041171-1	2018	The alpha2A-adrenoceptors (alpha2A-ARs) are Gi-coupled receptors, which prejunctionally inhibit the release of norepinephrine (NE) and epinephrine (Epi), and postjunctionally inhibit insulin secretion and lipolysis.	Epinephrine	114-125	adrenergic receptor, alpha 2a	Mus musculus	4-11
30041171-1	2018	The alpha2A-adrenoceptors (alpha2A-ARs) are Gi-coupled receptors, which prejunctionally inhibit the release of norepinephrine (NE) and epinephrine (Epi), and postjunctionally inhibit insulin secretion and lipolysis.	Epinephrine	114-125	adrenergic receptor, alpha 2a	Mus musculus	27-34
29193419-9	2018	These findings suggest that ALE supplementation may improve serum triglyceride level in A allele genotype of FTO-rs9939609 polymorphism in women with MetS.	Epinephrine	28-31	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	109-112
29308764-3	2018	The hypothalamus-pituitary-adrenal cortical (HPA) axis and sympathetic-adrenal medulla axis were activated and participated the initiation and progression of the stress response through the production of adrenocorticotropic hormone (ACTH), glucocorticoid (GC), epinephrine and norepinephrine (NE).	Epinephrine	261-272	proopiomelanocortin	Homo sapiens	233-237
29192066-0	2017	Epinephrine stimulates CXCL1 IL-1alpha, IL-6 secretion in isolated mouse limb muscle.	Epinephrine	0-11	chemokine (C-X-C motif) ligand 1	Mus musculus	23-28
28985281-9	2017	In contrast to most salt-sensitive hypertensives, striatin-associated SSBP is associated with normal plasma renin activity and reduced epinephrine levels.	Epinephrine	135-146	striatin	Homo sapiens	50-58
29202780-15	2017	Within the CFS group, all isoforms of TGF-beta were associated with plasma cortisol, urine norepinephrine and urine epinephrine, and this association pattern was related to fatigue score.	Epinephrine	94-105	transforming growth factor beta 1	Homo sapiens	38-46
29192066-0	2017	Epinephrine stimulates CXCL1 IL-1alpha, IL-6 secretion in isolated mouse limb muscle.	Epinephrine	0-11	interleukin 1 alpha	Mus musculus	29-38
29208684-6	2017	Furthermore, central NPY decreased plasma glucose and triacylglycerol under CT and HT and kept plasma corticosterone and epinephrine lower under HT NPY increased plasma taurine and anserine concentrations.	Epinephrine	121-132	neuropeptide Y	Homo sapiens	21-24
29192066-0	2017	Epinephrine stimulates CXCL1 IL-1alpha, IL-6 secretion in isolated mouse limb muscle.	Epinephrine	0-11	interleukin 6	Mus musculus	40-44
28836294-2	2017	This work scrutinizes kinetics of decomposition of adrenaline catalyzed by monoamine oxidase (MAO) A and B enzymes, a process controlling the levels of adrenaline in the central nervous system and other tissues.	Epinephrine	51-61	monoamine oxidase A	Homo sapiens	75-106
28277064-10	2017	The monoclonal anti-GluN1-S2 antibody (from BD Biosciences) inhibited activation and aggregation of human platelets in the presence of adrenaline, adenosine diphosphate, collagen, thrombin and a protease-activated receptor 1-activating peptide.	Epinephrine	135-145	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	20-28
28836294-2	2017	This work scrutinizes kinetics of decomposition of adrenaline catalyzed by monoamine oxidase (MAO) A and B enzymes, a process controlling the levels of adrenaline in the central nervous system and other tissues.	Epinephrine	152-162	monoamine oxidase A	Homo sapiens	75-106
28836294-3	2017	Experimental kinetic data for MAO A and B catalyzed decomposition of adrenaline are reported only in the form of the maximum reaction rate.	Epinephrine	69-79	monoamine oxidase A	Homo sapiens	30-35
28836294-5	2017	By using multiscale simulation on the Empirical Valence Bond (EVB) level, we studied the chemical reactivity of the MAO A catalyzed decomposition of adrenaline and we obtained a value of activation free energy of 17.3 +- 0.4 kcal/mol.	Epinephrine	149-159	monoamine oxidase A	Homo sapiens	116-121
28965949-5	2017	Further study found that adrenaline induced a cytoplasmic translocation of RNA binding protein HuR, which in turn activated TGFbeta, as shown by the SBE luciferase assay and phosphorylation of Smad2/3.	Epinephrine	25-35	transforming growth factor beta 1	Homo sapiens	124-131
28054256-8	2017	A significant correlation was found between adrenaline and sAA (r = 0.60, P = 0.01), but not between adrenaline and sCgA (r = 0.06, P = 0.79).	Epinephrine	44-54	amylase alpha 1A	Homo sapiens	59-62
29212111-4	2017	ECs from human lung, lymph, heart, intestine, skin and pulmonary artery can release and even produce FVIII in response to activation by epinephrine.	Epinephrine	136-147	coagulation factor VIII	Homo sapiens	101-106
29212111-6	2017	The beta-adrenergic receptor pathway is involved in increased FVIII levels following strenuous exercise.Conclusion The current available ex vivo and in vivo evidence suggests that endogenous FVIII is released by ECs from different vascular beds in response to epinephrine following strenuous exercise in patients with non-severe haemophilia.	Epinephrine	260-271	coagulation factor VIII	Homo sapiens	62-67
29212111-6	2017	The beta-adrenergic receptor pathway is involved in increased FVIII levels following strenuous exercise.Conclusion The current available ex vivo and in vivo evidence suggests that endogenous FVIII is released by ECs from different vascular beds in response to epinephrine following strenuous exercise in patients with non-severe haemophilia.	Epinephrine	260-271	coagulation factor VIII	Homo sapiens	191-196
28965949-0	2017	Adrenaline promotes epithelial-to-mesenchymal transition via HuR-TGFbeta regulatory axis in pancreatic cancer cells and the implication in cancer prognosis.	Epinephrine	0-10	ELAV like RNA binding protein 1	Homo sapiens	61-64
28965949-0	2017	Adrenaline promotes epithelial-to-mesenchymal transition via HuR-TGFbeta regulatory axis in pancreatic cancer cells and the implication in cancer prognosis.	Epinephrine	0-10	transforming growth factor beta 1	Homo sapiens	65-72
28965949-5	2017	Further study found that adrenaline induced a cytoplasmic translocation of RNA binding protein HuR, which in turn activated TGFbeta, as shown by the SBE luciferase assay and phosphorylation of Smad2/3.	Epinephrine	25-35	ELAV like RNA binding protein 1	Homo sapiens	95-98
28965949-5	2017	Further study found that adrenaline induced a cytoplasmic translocation of RNA binding protein HuR, which in turn activated TGFbeta, as shown by the SBE luciferase assay and phosphorylation of Smad2/3.	Epinephrine	25-35	SMAD family member 2	Homo sapiens	193-200
28965949-6	2017	Either HuR knockdown or TGFbeta inhibition reduced cell migration induced by adrenaline.	Epinephrine	77-87	ELAV like RNA binding protein 1	Homo sapiens	7-10
28965949-6	2017	Either HuR knockdown or TGFbeta inhibition reduced cell migration induced by adrenaline.	Epinephrine	77-87	transforming growth factor beta 1	Homo sapiens	24-31
29163071-3	2017	Tyrosine hydroxylase (TH) immune-positive cells of the brainstem correspond to dopamine (DA)-, norepinephrine (NE)-, and epinephrine (E)-containing cells.	Epinephrine	98-109	tyrosine hydroxylase	Mus musculus	0-20
29104573-5	2017	We investigated Rcan1 expression induced by histamine, platelet-activating factor (PAF), and epinephrine in primary human vein (HV)-/artery (HA)-derived endothelial cells (ECs) and human dermal microvascular ECs (HMVEC-D).	Epinephrine	93-104	regulator of calcineurin 1	Homo sapiens	16-21
29078099-0	2017	Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation.	Epinephrine	34-45	neuromedin U	Homo sapiens	0-12
28835457-5	2017	Noradrenaline and adrenaline dose-dependently suppressed the release of IL-27p28 in LPS/TLR4-activated macrophages, which was independent of alpha1 adrenoceptors.	Epinephrine	3-13	interleukin 27	Mus musculus	72-80
28754320-0	2017	Efficacy of vasopressin-epinephrine compared to epinephrine alone for out of hospital cardiac arrest patients: A systematic review and meta-analysis.	Epinephrine	24-35	arginine vasopressin	Homo sapiens	12-23
28754320-1	2017	OBJECTIVE: The aim of this study was to conduct a meta-analysis to evaluate the efficacy of vasopressin-epinephrine compared to epinephrine alone in patients who suffered out-of-hospital cardiac arrest (OHCA).	Epinephrine	104-115	arginine vasopressin	Homo sapiens	92-103
28754320-2	2017	METHODS: Relevant studies up to February 2017 were identified by searching in PubMed, EMBASE, the Cochrane Library, Wanfang for randomized controlled trials(RCTs) assigning adults with cardiac arrest to treatment with vasopressin-epinephrine (VEgroup) vs adrenaline (epinephrine) alone (E group).	Epinephrine	230-241	arginine vasopressin	Homo sapiens	218-229
28754320-7	2017	Subgroup showed that vasopressin-epinephrine has a significant association with improvements in ROSC for patients from Asia (OR=3.30, 95% CI=1.30-7.88); but for patients from other regions, there was no difference between vasopressin-epinephrine and epinephrine alone (OR=1.07, 95% CI=0.72-1.61).	Epinephrine	33-44	arginine vasopressin	Homo sapiens	21-32
28754320-7	2017	Subgroup showed that vasopressin-epinephrine has a significant association with improvements in ROSC for patients from Asia (OR=3.30, 95% CI=1.30-7.88); but for patients from other regions, there was no difference between vasopressin-epinephrine and epinephrine alone (OR=1.07, 95% CI=0.72-1.61).	Epinephrine	33-44	arginine vasopressin	Homo sapiens	222-233
28987360-5	2017	In addition, anticoagulant activity results in vivo showed that high dose of LSP-1 could significantly prolong bleeding time, coagulation time, prothrombin time, activated partial thromboplastin time, and thrombin time of hypercoagulable mice induced by adrenaline, reduce the content of fibrinogen and enhance antithrombin III activity.	Epinephrine	254-264	lymphocyte specific 1	Mus musculus	77-82
28835457-5	2017	Noradrenaline and adrenaline dose-dependently suppressed the release of IL-27p28 in LPS/TLR4-activated macrophages, which was independent of alpha1 adrenoceptors.	Epinephrine	3-13	toll-like receptor 4	Mus musculus	88-92
29087480-4	2017	In addition, the plasma level of adrenaline was increased by cold stress in mice, and treatment of macrophages with adrenaline stimulated phosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and TyrH.	Epinephrine	33-43	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	157-200
29087480-4	2017	In addition, the plasma level of adrenaline was increased by cold stress in mice, and treatment of macrophages with adrenaline stimulated phosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and TyrH.	Epinephrine	33-43	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	202-208
29087480-4	2017	In addition, the plasma level of adrenaline was increased by cold stress in mice, and treatment of macrophages with adrenaline stimulated phosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and TyrH.	Epinephrine	116-126	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	157-200
29087480-4	2017	In addition, the plasma level of adrenaline was increased by cold stress in mice, and treatment of macrophages with adrenaline stimulated phosphorylation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and TyrH.	Epinephrine	116-126	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	202-208
28397372-5	2017	Epinephrine (EPI) prevents impairment of cerebral autoregulation and hippocampal neuronal cell necrosis after TBI in female and male newborn and female juvenile but not male juvenile pigs via differential modulation of JNK.	Epinephrine	0-11	mitogen-activated protein kinase 8	Sus scrofa	219-222
29087480-5	2017	Genetic and pharmacological inhibition of CaMKII or PKA signaling diminished adrenaline-induced phosphorylation of TyrH in primary macrophages.	Epinephrine	77-87	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	42-48
28634082-5	2017	On the other hand, while adrenaline reduced the expression of pro-inflammatory cytokines (IL-1beta, IL-6) in rainbow trout, the opposite effect was observed in sea bream showing an increased expression (IL-1beta, IL-6).	Epinephrine	25-35	interleukin-1 beta	Oncorhynchus mykiss	90-98
28887324-5	2017	Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF.	Epinephrine	5-16	Yes1 associated transcriptional regulator	Homo sapiens	333-336
28887324-5	2017	Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF.	Epinephrine	5-16	ankyrin repeat domain 1	Homo sapiens	401-407
28887324-5	2017	Both epinephrine (EPI) and norepinephrine (NE) could directly inhibit breast cancer cell viability, as well as tumor growth in vivo EPI and NE activate the tumor suppressor Hippo signaling pathway, and the suppressive effect of exercise-conditioned serum was found to be mediated through phosphorylation and cytoplasmic retention of YAP and reduced expression of downstream target genes, for example, ANKRD1 and CTGF.	Epinephrine	5-16	cellular communication network factor 2	Homo sapiens	412-416
29254175-5	2017	Viperin overexpression reduces epinephrine- stimulated lipolysis in white adipose tissue, whereas viperin ASO increases expression of lipolytic genes.	Epinephrine	31-42	radical S-adenosyl methionine domain containing 2	Mus musculus	0-7
28578076-1	2017	Adrenaline changes expression of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1alpha), which is known as a regulator of muscle size, and atrogin-1/muscle atrophy F-box (MAFbx), which is a muscle-specific ubiquitin ligase.	Epinephrine	0-10	PPARG coactivator 1 alpha	Gallus gallus	52-120
28578076-6	2017	In addition, preinjection of the beta1-AR antagonist, acebutolol, and the beta2-AR antagonist, butoxamine, inhibited the adrenaline-induced increase in PGC-1alpha mRNA levels and the decrease in atrogin-1/MAFbx mRNA levels, respectively.	Epinephrine	121-131	F-box protein 32	Gallus gallus	195-204
28662545-6	2017	Platelet aggregation and 14 C serotonin in platelet-rich plasma (PRP) were impaired in response to ADP, epinephrine, collagen and arachidonic acid.	Epinephrine	104-115	complement component 4 binding protein alpha	Homo sapiens	65-68
28928674-0	2017	The Gly16 Allele of the G16R Single Nucleotide Polymorphism in the beta 2 -Adrenergic Receptor Gene Augments the Glycemic Response to Adrenaline in Humans.	Epinephrine	134-144	adrenoceptor beta 2	Homo sapiens	67-94
28928674-2	2017	This study tested whether the 46G &gt; A (G16R) single nucleotide polymorphism of the beta2-adrenergic receptor gene (ADRB2) influences the metabolic and cerebrovascular responses to administration of adrenaline.	Epinephrine	201-211	adrenoceptor beta 2	Homo sapiens	86-111
28928674-2	2017	This study tested whether the 46G &gt; A (G16R) single nucleotide polymorphism of the beta2-adrenergic receptor gene (ADRB2) influences the metabolic and cerebrovascular responses to administration of adrenaline.	Epinephrine	201-211	adrenoceptor beta 2	Homo sapiens	118-123
28928674-10	2017	The metabolic response of glucose during adrenergic stimulation with adrenaline is associated to the G16R polymorphism of ADRB2, although without effect on cerebral metabolism.	Epinephrine	69-79	adrenoceptor beta 2	Homo sapiens	122-127
28928674-11	2017	The differences in adrenaline-induced blood glucose increase between genotypes suggest an elevated beta2-adrenergic response in the Gly16 homozygotes with increased adrenaline-induced glycolysis compared to Arg16 homozygotes.	Epinephrine	19-29	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	99-104
28928674-11	2017	The differences in adrenaline-induced blood glucose increase between genotypes suggest an elevated beta2-adrenergic response in the Gly16 homozygotes with increased adrenaline-induced glycolysis compared to Arg16 homozygotes.	Epinephrine	165-175	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	99-104
28663252-8	2017	In vivo, loss of GLUT3 in platelets increased survival in a collagen/epinephrine model of pulmonary embolism, and in a K/BxN model of autoimmune inflammatory disease, platelet-specific GLUT3 knockout mice display decreased disease progression.	Epinephrine	69-80	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	17-22
28634082-5	2017	On the other hand, while adrenaline reduced the expression of pro-inflammatory cytokines (IL-1beta, IL-6) in rainbow trout, the opposite effect was observed in sea bream showing an increased expression (IL-1beta, IL-6).	Epinephrine	25-35	interleukin-6	Oncorhynchus mykiss	100-104
28817667-4	2017	We found that thrombin, Trap-6, arachidonic acid, collagen, A23187, epinephrine and ADP significantly increased glycolytic flux (3-38 times vs. non-activated platelets) whereas ristocetin was ineffective.	Epinephrine	68-79	coagulation factor II, thrombin	Homo sapiens	14-22
28451718-10	2017	Calibration curves using standards between 25 and 125 mug L-1 gave a high level of linearity with a correlation coefficient of 0.990 for epinephrine and 0.996 for dopamine (N = 5).	Epinephrine	137-148	immunoglobulin kappa variable 1-16	Homo sapiens	58-61
28603032-0	2017	beta2-adrenergic receptor-mediated in vitro regulation of human hepatic drug transporter expression by epinephrine.	Epinephrine	103-114	adrenoceptor beta 2	Homo sapiens	0-25
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	solute carrier family 10 member 1	Homo sapiens	164-168
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	solute carrier organic anion transporter family member 1B1	Homo sapiens	170-177
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	solute carrier organic anion transporter family member 2B1	Homo sapiens	179-186
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	solute carrier family 22 member 7	Homo sapiens	188-192
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	solute carrier family 22 member 9	Homo sapiens	194-198
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	solute carrier family 22 member 1	Homo sapiens	203-207
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	ATP binding cassette subfamily C member 2	Homo sapiens	236-240
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	ATP binding cassette subfamily C member 3	Homo sapiens	242-246
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	ATP binding cassette subfamily B member 11	Homo sapiens	251-255
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	ATP binding cassette subfamily B member 1	Homo sapiens	284-288
28603032-3	2017	Treatment of primary human hepatocytes with 10muM epinephrine for 24h repressed mRNA expression of various transporters, such as the sinusoidal influx transporters NTCP, OATP1B1, OATP2B1, OAT2, OAT7 and OCT1 and the efflux transporters MRP2, MRP3 and BSEP, whereas it induced that of MDR1, but failed to alter that of BCRP.	Epinephrine	50-61	BCR pseudogene 1	Homo sapiens	318-322
28603032-4	2017	Most of these changes in transporter mRNA levels were also found in epinephrine-exposed human highly-differentiated hepatoma HepaRG cells, which additionally exhibited reduced protein expression of OATP2B1 and MRP3, increased expression of P-glycoprotein and decreased transport activity of NTCP, OATPs and OCT1.	Epinephrine	68-79	solute carrier organic anion transporter family member 2B1	Homo sapiens	198-205
28603032-4	2017	Most of these changes in transporter mRNA levels were also found in epinephrine-exposed human highly-differentiated hepatoma HepaRG cells, which additionally exhibited reduced protein expression of OATP2B1 and MRP3, increased expression of P-glycoprotein and decreased transport activity of NTCP, OATPs and OCT1.	Epinephrine	68-79	ATP binding cassette subfamily C member 3	Homo sapiens	210-214
28603032-4	2017	Most of these changes in transporter mRNA levels were also found in epinephrine-exposed human highly-differentiated hepatoma HepaRG cells, which additionally exhibited reduced protein expression of OATP2B1 and MRP3, increased expression of P-glycoprotein and decreased transport activity of NTCP, OATPs and OCT1.	Epinephrine	68-79	solute carrier family 10 member 1	Homo sapiens	291-295
28603032-4	2017	Most of these changes in transporter mRNA levels were also found in epinephrine-exposed human highly-differentiated hepatoma HepaRG cells, which additionally exhibited reduced protein expression of OATP2B1 and MRP3, increased expression of P-glycoprotein and decreased transport activity of NTCP, OATPs and OCT1.	Epinephrine	68-79	solute carrier family 22 member 1	Homo sapiens	307-311
28603032-5	2017	Epinephrine effects towards transporter mRNA expression in human hepatocytes were next shown to be correlated to those of the selective beta2-adrenoreceptor (ADR) agonist fenoterol, of the adenylate cyclase activator forskolin and of the cAMP analogue 8-bromo-cAMP.	Epinephrine	0-11	adrenoceptor beta 2	Homo sapiens	136-156
29069780-3	2017	Epinephrine, an AR agonist, increased membrane recruitment as well as GTP-photoaffinity of TG2, inducing GD3 synthase gene expression.	Epinephrine	0-11	transglutaminase 2	Homo sapiens	91-94
29069780-3	2017	Epinephrine, an AR agonist, increased membrane recruitment as well as GTP-photoaffinity of TG2, inducing GD3 synthase gene expression.	Epinephrine	0-11	GRDX	Homo sapiens	105-108
29069780-4	2017	Epinephrine activated PI3K/Akt signaling and GTPase downstream of TG2 activated Akt.	Epinephrine	0-11	AKT serine/threonine kinase 1	Homo sapiens	27-30
29069780-4	2017	Epinephrine activated PI3K/Akt signaling and GTPase downstream of TG2 activated Akt.	Epinephrine	0-11	transglutaminase 2	Homo sapiens	66-69
29069780-4	2017	Epinephrine activated PI3K/Akt signaling and GTPase downstream of TG2 activated Akt.	Epinephrine	0-11	AKT serine/threonine kinase 1	Homo sapiens	80-83
28603032-6	2017	In addition, the non-selective beta-ADR antagonist carazolol and the selective beta2-ADR antagonist ICI-118,551, unlike the alpha-ADR antagonist phentolamine, suppressed epinephrine-mediated repressions of transporter mRNA expression.	Epinephrine	170-181	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	79-84
28603032-7	2017	Taken together, these data indicate that epinephrine regulates in vitro expression of main hepatic drug transporters in a beta2-ADR/adenylate cyclase/cAMP-dependent manner.	Epinephrine	41-52	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	122-127
28797292-9	2017	ALE also significantly normalized the stress-induced activation of astrocytes and microglial cells in the hippocampus as well as the elevation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta).	Epinephrine	0-3	tumor necrosis factor	Mus musculus	182-209
28797292-9	2017	ALE also significantly normalized the stress-induced activation of astrocytes and microglial cells in the hippocampus as well as the elevation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta).	Epinephrine	0-3	tumor necrosis factor	Mus musculus	211-220
28797292-9	2017	ALE also significantly normalized the stress-induced activation of astrocytes and microglial cells in the hippocampus as well as the elevation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta).	Epinephrine	0-3	interleukin 1 beta	Mus musculus	226-244
28797292-9	2017	ALE also significantly normalized the stress-induced activation of astrocytes and microglial cells in the hippocampus as well as the elevation of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1beta).	Epinephrine	0-3	interleukin 1 beta	Mus musculus	246-254
28797292-11	2017	The anti-oxidative stress effects of ALE were supported by the results of antioxidant components, 4-hydroxynonenal (4-HNE), NADPH oxidase 2 (NOX2), inducible nitric oxide synthase (iNOS) and NFE2L2 (Nrf2) in the hippocampal tissues.	Epinephrine	37-40	cytochrome b-245, beta polypeptide	Mus musculus	124-139
28797292-11	2017	The anti-oxidative stress effects of ALE were supported by the results of antioxidant components, 4-hydroxynonenal (4-HNE), NADPH oxidase 2 (NOX2), inducible nitric oxide synthase (iNOS) and NFE2L2 (Nrf2) in the hippocampal tissues.	Epinephrine	37-40	cytochrome b-245, beta polypeptide	Mus musculus	141-145
28797292-11	2017	The anti-oxidative stress effects of ALE were supported by the results of antioxidant components, 4-hydroxynonenal (4-HNE), NADPH oxidase 2 (NOX2), inducible nitric oxide synthase (iNOS) and NFE2L2 (Nrf2) in the hippocampal tissues.	Epinephrine	37-40	nitric oxide synthase 2, inducible	Mus musculus	148-179
28797292-11	2017	The anti-oxidative stress effects of ALE were supported by the results of antioxidant components, 4-hydroxynonenal (4-HNE), NADPH oxidase 2 (NOX2), inducible nitric oxide synthase (iNOS) and NFE2L2 (Nrf2) in the hippocampal tissues.	Epinephrine	37-40	nitric oxide synthase 2, inducible	Mus musculus	181-185
28797292-11	2017	The anti-oxidative stress effects of ALE were supported by the results of antioxidant components, 4-hydroxynonenal (4-HNE), NADPH oxidase 2 (NOX2), inducible nitric oxide synthase (iNOS) and NFE2L2 (Nrf2) in the hippocampal tissues.	Epinephrine	37-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	191-197
28797292-11	2017	The anti-oxidative stress effects of ALE were supported by the results of antioxidant components, 4-hydroxynonenal (4-HNE), NADPH oxidase 2 (NOX2), inducible nitric oxide synthase (iNOS) and NFE2L2 (Nrf2) in the hippocampal tissues.	Epinephrine	37-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	199-203
28451718-11	2017	The limit of detection, calculated as three times signal-to-noise ratio, was 5.0 mug L-1 for epinephrine and 1.8 mug L-1 for dopamine.	Epinephrine	93-104	immunoglobulin kappa variable 1-16	Homo sapiens	85-88
28430981-7	2017	Administration of CNS GLP-1 increased fasting glucose, glucagon, corticosterone, and epinephrine and blunted insulin secretion in response to hyperglycemia.	Epinephrine	85-96	glucagon	Rattus norvegicus	22-27
28472693-7	2017	Results showed that CRH administration increased plasma noradrenaline and cortisol concentrations, sAA activity, heart rate, as well as self-reported side effects (i.e. flushing in the facial area, heart rate changes, giddiness, malaise and restlessness) and stress perception, while plasma adrenaline levels remained unaffected.	Epinephrine	59-69	corticotropin releasing hormone	Homo sapiens	20-23
28553949-6	2017	Epinephrine, a hydrophilic endogenous ligand, accesses the Golgi-localized receptor pool by facilitated transport requiring the organic cation transporter 3 (OCT3), whereas drugs can access the Golgi pool by passive diffusion according to hydrophobicity.	Epinephrine	0-11	OCTN3	Homo sapiens	128-156
28187222-5	2017	Results: In IR adipocytes, uptake of D3 and 25-hydroxyvitamin-D3 was higher, but, after adrenaline stimulation, the decrement in D3 and 25-hydroxyvitamin-D3 was stronger in control cells, which also showed increased expression of Cyp27a1 and Cyp27b1 and higher levels of 25-hydroxyvitamin-D3.	Epinephrine	88-98	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	230-237
28187222-5	2017	Results: In IR adipocytes, uptake of D3 and 25-hydroxyvitamin-D3 was higher, but, after adrenaline stimulation, the decrement in D3 and 25-hydroxyvitamin-D3 was stronger in control cells, which also showed increased expression of Cyp27a1 and Cyp27b1 and higher levels of 25-hydroxyvitamin-D3.	Epinephrine	88-98	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	242-249
28187222-6	2017	In SAT from obese subjects, adrenaline-induced release of D3 and 25-hydroxyvitamin-D3 was blunted; in both IR cells and obese SAT, protein expression of beta2-adrenergic receptor was reduced.	Epinephrine	28-38	adrenoceptor beta 2	Homo sapiens	153-178
28553949-6	2017	Epinephrine, a hydrophilic endogenous ligand, accesses the Golgi-localized receptor pool by facilitated transport requiring the organic cation transporter 3 (OCT3), whereas drugs can access the Golgi pool by passive diffusion according to hydrophobicity.	Epinephrine	0-11	OCTN3	Homo sapiens	158-162
29062328-7	2017	Plasma levels of CRP, ferritin and dopamine were higher in the group of smokers in the setting of lower levels of epinephrine, and leukocyte vitamin C, with CRP and vitamin C attaining statistical significance (P&lt;0.04 and P&lt;0.02 respectively).	Epinephrine	114-125	C-reactive protein	Homo sapiens	17-20
28300864-7	2017	Using gene-based association tests of rare and low-frequency variants, we found significant associations of HYAL2 with increased ADP-induced aggregation (p = 1.07x10-7) and GSTZ1 with increased epinephrine-induced aggregation (p = 1.62x10-6).	Epinephrine	194-205	hyaluronidase 2	Homo sapiens	108-113
28300864-7	2017	Using gene-based association tests of rare and low-frequency variants, we found significant associations of HYAL2 with increased ADP-induced aggregation (p = 1.07x10-7) and GSTZ1 with increased epinephrine-induced aggregation (p = 1.62x10-6).	Epinephrine	194-205	glutathione S-transferase zeta 1	Homo sapiens	173-178
28300864-8	2017	HYAL2 also showed suggestive associations with epinephrine-induced aggregation (p = 2.64x10-5).	Epinephrine	47-58	hyaluronidase 2	Homo sapiens	0-5
28263233-11	2017	In addition, lactate dehydrogenase, creatine kinase, and cardiac troponin I levels in DFE and epinephrine + DFE administered rats were significantly elevated as compared with control.	Epinephrine	94-105	troponin I3, cardiac type	Rattus norvegicus	57-75
28328682-10	2017	RESULTS: Endothelial activation and injury as indexed by permeability, ICAM expression, soluble thrombomodulin were increased by H2O2 and/or epinephrine exposure.	Epinephrine	141-152	thrombomodulin	Homo sapiens	96-110
28328682-11	2017	Biomarkers of endothelial coagulation profile (tPA/PAI-1) demonstrated a profibrinolytic profile (increased tPA and tPA/PAI-1 ratio) after challenge by H2O2 and/or epinephrine.	Epinephrine	164-175	plasminogen activator, tissue type	Homo sapiens	47-50
28328682-11	2017	Biomarkers of endothelial coagulation profile (tPA/PAI-1) demonstrated a profibrinolytic profile (increased tPA and tPA/PAI-1 ratio) after challenge by H2O2 and/or epinephrine.	Epinephrine	164-175	serpin family E member 1	Homo sapiens	51-56
26705390-6	2017	The BDNF Met allele predisposed to carotid artery thrombosis FeCl3-induced and to death after collagen/epinephrine injection.	Epinephrine	103-114	brain derived neurotrophic factor	Mus musculus	4-8
28475489-2	2017	Materials and methods Our study aimed to analyze the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, monocyte chemoattractant protein (MCP)-1 and IL-8 by whole blood cells following short-term exposure to epinephrine (Epi) and 17beta-estradiol (E2) in the presence or absence of lipopolysaccharide (LPS).	Epinephrine	230-241	C-C motif chemokine ligand 2	Homo sapiens	126-166
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	Epinephrine	154-165	solute carrier family 22 member 3	Rattus norvegicus	0-28
28502326-2	2017	Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+-K+-ATPase pumps present in skeletal muscle.	Epinephrine	26-37	mucin 7, secreted	Homo sapiens	110-113
28502326-2	2017	Elevations in circulating epinephrine and norepinephrine unmask an interdependency that exists between K+ and Mg2+ based on their regulation of a large number of Mg2+-dependent Na+-K+-ATPase pumps present in skeletal muscle.	Epinephrine	26-37	mucin 7, secreted	Homo sapiens	162-165
28212885-3	2017	Human macrophages exposed to epinephrine and TNFalpha, or macrophages generated in 6day cultures in the presence of epinephrine, expressed high levels of COX-2, IDO and IL-10, and strongly suppressed both the proliferation and IFNgamma production of CD8+ T cells.	Epinephrine	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	154-159
28212885-3	2017	Human macrophages exposed to epinephrine and TNFalpha, or macrophages generated in 6day cultures in the presence of epinephrine, expressed high levels of COX-2, IDO and IL-10, and strongly suppressed both the proliferation and IFNgamma production of CD8+ T cells.	Epinephrine	29-40	indoleamine 2,3-dioxygenase 1	Homo sapiens	161-164
28212885-3	2017	Human macrophages exposed to epinephrine and TNFalpha, or macrophages generated in 6day cultures in the presence of epinephrine, expressed high levels of COX-2, IDO and IL-10, and strongly suppressed both the proliferation and IFNgamma production of CD8+ T cells.	Epinephrine	29-40	interleukin 10	Homo sapiens	169-174
28212885-3	2017	Human macrophages exposed to epinephrine and TNFalpha, or macrophages generated in 6day cultures in the presence of epinephrine, expressed high levels of COX-2, IDO and IL-10, and strongly suppressed both the proliferation and IFNgamma production of CD8+ T cells.	Epinephrine	29-40	CD8a molecule	Homo sapiens	250-253
28212885-4	2017	These suppressive effects of epinephrine were counteracted by celecoxib, a selective inhibitor of COX-2 activity, which inhibited the induction of immunosuppressive factors (including the elevated expression of COX-2 itself) and the ability of epinephrine-exposed macrophages to suppress CD8+ T cell responses.	Epinephrine	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	98-103
28212885-4	2017	These suppressive effects of epinephrine were counteracted by celecoxib, a selective inhibitor of COX-2 activity, which inhibited the induction of immunosuppressive factors (including the elevated expression of COX-2 itself) and the ability of epinephrine-exposed macrophages to suppress CD8+ T cell responses.	Epinephrine	29-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	211-216
28212885-4	2017	These suppressive effects of epinephrine were counteracted by celecoxib, a selective inhibitor of COX-2 activity, which inhibited the induction of immunosuppressive factors (including the elevated expression of COX-2 itself) and the ability of epinephrine-exposed macrophages to suppress CD8+ T cell responses.	Epinephrine	29-40	CD8a molecule	Homo sapiens	288-291
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	Epinephrine	154-165	solute carrier family 22 member 3	Rattus norvegicus	30-34
28028021-13	2017	Deletion of Ask1 also reduces thrombosis as assessed by delayed vessel occlusion of carotid artery after FeCl3-induced injury and protects against collagen/epinephrine-induced pulmonary thromboembolism.	Epinephrine	156-167	mitogen-activated protein kinase kinase kinase 5	Mus musculus	12-16
28008098-6	2017	BNP prevented the physiological decrease in cortisol during the late morning hours leading to elevated serum cortisol levels (P = 0.022) and increased circulating epinephrine and norepinephrine concentrations (P = 0.018 and P = 0.036, respectively).	Epinephrine	163-174	natriuretic peptide B	Homo sapiens	0-3
28008098-10	2017	Here we report that intravenous administration of BNP in men leads to increases in adrenal hormones cortisol, epinephrine, and norepinephrine.	Epinephrine	110-121	natriuretic peptide B	Homo sapiens	50-53
27979380-8	2017	Plasma epinephrine was decreased by NPY in fed chicks, but plasma concentrations of norepinephrine and epinephrine were increased significantly by NPY in fasted-heat exposed chicks.	Epinephrine	87-98	neuropeptide Y	Homo sapiens	147-150
28230659-4	2017	The Ca decrease was shorter after inhibition of the Na/K pump with ouabain (10 and 100 muM) but prolonged when the alpha2A adrenoceptors were activated with clonidine (1 and 10 nM) or epinephrine (10 nM).	Epinephrine	184-195	adrenergic receptor, alpha 2a	Mus musculus	115-122
28256511-5	2017	Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF.	Epinephrine	38-49	zyxin	Mus musculus	0-5
28256511-5	2017	Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF.	Epinephrine	38-49	Von Willebrand factor	Mus musculus	61-64
28194935-2	2017	As the 5-HT2C receptor displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine, and gamma-aminobutyric acid (GABA), abnormalities of the 5-HT2C receptor are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, and anxiety.	Epinephrine	116-127	5-hydroxytryptamine receptor 2C	Rattus norvegicus	7-13
28194935-2	2017	As the 5-HT2C receptor displays multiple actions on various neurotransmitter systems including glutamate, dopamine, epinephrine, and gamma-aminobutyric acid (GABA), abnormalities of the 5-HT2C receptor are associated with psychiatric diseases such as depression, schizophrenia, drug abuse, and anxiety.	Epinephrine	116-127	5-hydroxytryptamine receptor 2C	Rattus norvegicus	186-192
28177221-2	2017	Here we present a two-dimensional (2D) surface-enhanced resonance Raman scattering (SERRS) platform, which takes advantages of the high selectivity of the SERRS sensor as well as the sensitivity and reproducibility of the interfacial SERS platform, for detecting trace epinephrine (EP) in the serum.	Epinephrine	269-280	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	234-238
28177221-2	2017	Here we present a two-dimensional (2D) surface-enhanced resonance Raman scattering (SERRS) platform, which takes advantages of the high selectivity of the SERRS sensor as well as the sensitivity and reproducibility of the interfacial SERS platform, for detecting trace epinephrine (EP) in the serum.	Epinephrine	282-284	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	234-238
28414287-3	2017	In blood adrenaline administration to animals caused an increase in the activity of AMPD, AD, 5$N and GPO, and the increase the level of CD in the blood increases.	Epinephrine	9-19	adenosine monophosphate deaminase 1	Homo sapiens	84-88
28011264-7	2017	This inhibitory response in TNF production by exercise was mirrored by beta-AR agonists in an agonist-specific and dose-dependent manner in vitro: similar isoproterenol (EC50=2.1-4.7x10-10M) and epinephrine (EC50=4.4-10x10-10M) potency and higher norepinephrine concentrations (EC50=2.6-4.3x10-8M) needed for the effects.	Epinephrine	195-206	tumor necrosis factor	Homo sapiens	28-31
28011264-8	2017	Importantly, epinephrine levels observed during acute exercise in vivo significantly inhibited TNF production in vitro.	Epinephrine	13-24	tumor necrosis factor	Homo sapiens	95-98
28011264-10	2017	We conclude that the downregulation of monocytic TNF production during acute exercise is mediated by elevated epinephrine levels through beta2-ARs.	Epinephrine	110-121	tumor necrosis factor	Homo sapiens	49-52
28011264-10	2017	We conclude that the downregulation of monocytic TNF production during acute exercise is mediated by elevated epinephrine levels through beta2-ARs.	Epinephrine	110-121	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	137-142
28028077-1	2017	In pancreatic beta-cells, pharmacological concentrations of catecholamines, including adrenaline, have been used to inhibit insulin release and explore the multiple mechanisms involved.	Epinephrine	86-96	insulin	Homo sapiens	124-131
28028077-5	2017	Results showed that physiological concentrations of adrenaline strongly suppressed glucose-induced and incretin-potentiated cAMP production and insulin secretion and inhibited NSCCs current and membrane excitability via the alpha2A-adrenoceptor in wild-type mice; however, insulin secretion was not attenuated in TRPM2-knockout (KO) mice.	Epinephrine	52-62	adrenergic receptor, alpha 2a	Mus musculus	224-244
28028077-5	2017	Results showed that physiological concentrations of adrenaline strongly suppressed glucose-induced and incretin-potentiated cAMP production and insulin secretion and inhibited NSCCs current and membrane excitability via the alpha2A-adrenoceptor in wild-type mice; however, insulin secretion was not attenuated in TRPM2-knockout (KO) mice.	Epinephrine	52-62	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	313-318
28414287-6	2017	Combined administration of metoprolol and adrenaline to animals was accompanied by an increase in the activity of AD, AMPD, 5$N, a decrease in the activity of GR, GPO, catalase, and a decrease in MDA in the blood.	Epinephrine	42-52	adenosine monophosphate deaminase 1	Homo sapiens	118-122
27743246-7	2017	However, the immunostaining of CgA in the tumor cells showed peculiar dot-like staining located corresponding to Golgi complex in the perinuclear area, rather than the diffuse cytoplasmic staining usually observed in epinephrine- or norepinephrine-producing functional pheochromocytomas and paragangliomas.	Epinephrine	217-228	chromogranin A	Homo sapiens	31-34
28414287-6	2017	Combined administration of metoprolol and adrenaline to animals was accompanied by an increase in the activity of AD, AMPD, 5$N, a decrease in the activity of GR, GPO, catalase, and a decrease in MDA in the blood.	Epinephrine	42-52	glutathione-disulfide reductase	Homo sapiens	159-161
28414287-6	2017	Combined administration of metoprolol and adrenaline to animals was accompanied by an increase in the activity of AD, AMPD, 5$N, a decrease in the activity of GR, GPO, catalase, and a decrease in MDA in the blood.	Epinephrine	42-52	catalase	Homo sapiens	168-176
28414287-7	2017	In the heart, adrenaline injection was accompanied by an increase in the MDA level, a decrease in 5$N activity and an increase in the ratio of the activities of the enzymes AD+AMPD/5$N.	Epinephrine	14-24	adenosine monophosphate deaminase 1	Homo sapiens	176-180
28414287-9	2017	The combined administration of metoprolol and adrenaline in the heart was accompanied by activation of AD, AMPD and 5$N, and a decrease in the amount of MDA and CD, and a decrease in the activity of GR, GPO, and catalase.	Epinephrine	46-56	adenosine monophosphate deaminase 1	Homo sapiens	107-111
28414287-9	2017	The combined administration of metoprolol and adrenaline in the heart was accompanied by activation of AD, AMPD and 5$N, and a decrease in the amount of MDA and CD, and a decrease in the activity of GR, GPO, and catalase.	Epinephrine	46-56	glutathione-disulfide reductase	Homo sapiens	199-201
28414287-9	2017	The combined administration of metoprolol and adrenaline in the heart was accompanied by activation of AD, AMPD and 5$N, and a decrease in the amount of MDA and CD, and a decrease in the activity of GR, GPO, and catalase.	Epinephrine	46-56	catalase	Homo sapiens	212-220
28414287-10	2017	In the liver adrenaline caused an increase in MDA and DC levels, activation of catalase, AD, AMPD, and 5$N.	Epinephrine	13-23	catalase	Homo sapiens	79-87
28414287-10	2017	In the liver adrenaline caused an increase in MDA and DC levels, activation of catalase, AD, AMPD, and 5$N.	Epinephrine	13-23	adenosine monophosphate deaminase 1	Homo sapiens	93-97
28298660-14	2017	Hyperlactatemia is a common accompaniment to treatment with beta2-agonists such as epinephrine.	Epinephrine	83-94	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	60-65
28074314-2	2017	beta-adrenergic receptors (beta-AR) are targets of endogenous catecholamines such as epinephrine that have gained importance in the context of cancer biology.	Epinephrine	85-96	adrenoceptor beta 2	Homo sapiens	27-34
28074314-5	2017	In MCF-10A cells having knocked-down beta2-AR, epinephrine increased cell proliferation and migration, similar to the response by tumor cells.	Epinephrine	47-58	adrenoceptor beta 2	Homo sapiens	37-45
27997103-1	2017	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine (SAM)-dependent conversion of norepinephrine to epinephrine.	Epinephrine	117-128	phenylethanolamine N-methyltransferase	Homo sapiens	0-38
28865224-3	2017	The aim of this study was to investigate adrenal medulla activity in vitro depending, on a dose of CRH, AVP and OXY on adrenaline and noradrenaline release.	Epinephrine	119-129	corticoliberin	Ovis aries	99-102
28865224-3	2017	The aim of this study was to investigate adrenal medulla activity in vitro depending, on a dose of CRH, AVP and OXY on adrenaline and noradrenaline release.	Epinephrine	119-129	vasopressin-neurophysin 2-copeptin	Ovis aries	104-107
28865224-5	2017	The results showed that CRH stimulates adrenaline and noradrenaline release from the adrenal medulla tissue.	Epinephrine	39-49	corticoliberin	Ovis aries	24-27
28865224-6	2017	The stimulating influence of AVP on adrenaline release was visible after the application of the two lower doses of this neuropeptide; however, AVP reduced noradrenaline release from the adrenal medulla tissue.	Epinephrine	36-46	vasopressin-neurophysin 2-copeptin	Ovis aries	29-32
27997103-1	2017	Phenylethanolamine N-methyltransferase (PNMT) catalyzes the S-adenosyl-l-methionine (SAM)-dependent conversion of norepinephrine to epinephrine.	Epinephrine	117-128	phenylethanolamine N-methyltransferase	Homo sapiens	40-44
27997103-6	2017	The model provides information on the geometry and electrostatics of the human PNMT transition state structure and indicates that human PNMT catalyzes the formation of epinephrine through an early SN2 transition state in which methyl transfer is rate-limiting.	Epinephrine	168-179	phenylethanolamine N-methyltransferase	Homo sapiens	79-83
27997103-6	2017	The model provides information on the geometry and electrostatics of the human PNMT transition state structure and indicates that human PNMT catalyzes the formation of epinephrine through an early SN2 transition state in which methyl transfer is rate-limiting.	Epinephrine	168-179	phenylethanolamine N-methyltransferase	Homo sapiens	136-140
28100251-1	2017	Aromatic L-amino acid decarboxylase deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder that leads to a severe combined deficiency of serotonin, dopamine, norepinephrine and epinephrine.	Epinephrine	180-191	dopa decarboxylase	Homo sapiens	0-35
27590869-4	2017	OBJECTIVES: The authors investigated the effects of tumescent solution containing lidocaine and epinephrine on the phosphorylation status of perilipin in adipocytes.	Epinephrine	96-107	perilipin 1	Homo sapiens	141-150
26214220-1	2017	OBJECTIVE: LAT (lidocaine, adrenaline, and tetracaine) gel is a topical anesthetic that can be applied on lacerations before suturing.	Epinephrine	27-37	linker for activation of T cells	Homo sapiens	11-14
28541755-3	2017	Arginine vasopressin (AVP) has been proposed as an alternative if epinephrine does not correct arterial hypotension.	Epinephrine	66-77	arginine vasopressin	Rattus norvegicus	9-20
28076805-10	2017	In addition, we showed that incubation of normal RBCs and SS-RBCs with epinephrine, a catecholamine that binds to the beta-adrenergic receptor and activates the cAMP-PKA-dependent pathway, caused a significant increase in the frequency of active ICAM-4 receptors in both normal RBCs and SS-RBCs.	Epinephrine	71-82	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	Homo sapiens	246-252
28084430-1	2017	In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline.	Epinephrine	223-233	phenylethanolamine-N-methyltransferase	Mus musculus	109-147
28084430-1	2017	In the present study, channelrhodopsin 2 (ChR2) was specifically introduced into murine cells expressing the Phenylethanolamine n-methyltransferase (Pnmt) gene, which encodes for the enzyme responsible for conversion of noradrenaline to adrenaline.	Epinephrine	223-233	phenylethanolamine-N-methyltransferase	Mus musculus	149-153
28198975-9	2017	The immunostaining for RUNX2 and osteopontin was positive in the osteoblastic lineage cells of neoformed bone for the CTL and ALE groups in both periods (14 and 42 days).	Epinephrine	126-129	RUNX family transcription factor 2	Rattus norvegicus	23-28
27671240-0	2017	Adrenaline inhibits osteogenesis via repressing miR-21 expression.	Epinephrine	0-10	microRNA 21	Homo sapiens	48-54
27671240-2	2017	In this study, we found that the psychological stress mediator adrenaline inhibited osteogenic differentiation of human bone marrow-derived stem cells (hMSC) by reducing microRNA-21 (miR-21) expression.	Epinephrine	63-73	microRNA 21	Homo sapiens	170-181
27671240-2	2017	In this study, we found that the psychological stress mediator adrenaline inhibited osteogenic differentiation of human bone marrow-derived stem cells (hMSC) by reducing microRNA-21 (miR-21) expression.	Epinephrine	63-73	microRNA 21	Homo sapiens	183-189
27671240-3	2017	Briefly, adrenaline significantly inhibited the osteogenic differentiation of hMSCs, as observed with both Alizarin red staining and maker gene expression (RUNX2, OSX, OCN, and OPN).	Epinephrine	9-19	RUNX family transcription factor 2	Homo sapiens	156-161
27671240-3	2017	Briefly, adrenaline significantly inhibited the osteogenic differentiation of hMSCs, as observed with both Alizarin red staining and maker gene expression (RUNX2, OSX, OCN, and OPN).	Epinephrine	9-19	Sp7 transcription factor	Homo sapiens	163-166
27671240-3	2017	Briefly, adrenaline significantly inhibited the osteogenic differentiation of hMSCs, as observed with both Alizarin red staining and maker gene expression (RUNX2, OSX, OCN, and OPN).	Epinephrine	9-19	bone gamma-carboxyglutamate protein	Homo sapiens	168-171
27671240-3	2017	Briefly, adrenaline significantly inhibited the osteogenic differentiation of hMSCs, as observed with both Alizarin red staining and maker gene expression (RUNX2, OSX, OCN, and OPN).	Epinephrine	9-19	secreted phosphoprotein 1	Homo sapiens	177-180
27671240-4	2017	During this process, miR-21 was suppressed by adrenaline via inhibition of histone acetylation, as verified by H3K9Ac chromatin immunoprecipitation (ChIP) assay.	Epinephrine	46-56	microRNA 21	Homo sapiens	21-27
27671240-5	2017	MiR-21 was confirmed to promote hMSC osteogenic differentiation, and overexpression of miR-21 reversed the impeditive effect of adrenaline on hMSC osteogenic differentiation.	Epinephrine	128-138	microRNA 21	Homo sapiens	87-93
27671240-6	2017	Our results demonstrate that down-regulation of miR-21 is responsible for the adrenaline-mediated inhibition of hMSC osteogenic differentiation.	Epinephrine	78-88	microRNA 21	Homo sapiens	48-54
28198975-9	2017	The immunostaining for RUNX2 and osteopontin was positive in the osteoblastic lineage cells of neoformed bone for the CTL and ALE groups in both periods (14 and 42 days).	Epinephrine	126-129	secreted phosphoprotein 1	Rattus norvegicus	33-44
28198975-11	2017	Conclusion: There was a decrease of osteocalcin precipitation at 42 days for the ALE and OST groups.	Epinephrine	81-84	bone gamma-carboxyglutamate protein	Rattus norvegicus	36-47
28738359-10	2017	Adrenaline was correlated with CD16+ monocyte expansion with a lower inflammatory pattern.	Epinephrine	0-10	Fc gamma receptor IIIa	Homo sapiens	31-35
28848192-9	2017	In vitro activation of splenocytes isolated from immunized mice with agonists targeting TLR2 and NOD2 together with beta2-adrenergic activation (induced by epinephrine, norepinephrine, or salbutamol) resulted in decreased IFN-gamma but increased IL-17 immune responses.	Epinephrine	156-167	hemoglobin, beta adult minor chain	Mus musculus	116-121
28066248-2	2016	One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine.	Epinephrine	248-259	catechol-O-methyltransferase	Rattus norvegicus	68-96
28137226-10	2017	Subcutaneous and intramuscular beta2 agonists such as terbutaline and epinephrine may be considered for children with severe asthma exacerbation who have poor air entry, are uncooperative with nebulized therapy, or have poor response to nebulized therapy.	Epinephrine	70-81	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	31-36
28066248-2	2016	One of the main enzymes to take into account in pharmacogenomics is catechol O-methyltransferase (COMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to catechols and catecholamines, like the neurotransmitters dopamine, epinephrine, and norepinephrine.	Epinephrine	248-259	catechol-O-methyltransferase	Rattus norvegicus	98-102
27769893-1	2016	Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Rattus norvegicus	69-107
27999602-14	2016	The patient was diagnosed with lactase tablet induced anaphylaxis due to synthetic lactase enzyme IgE mediated allergy, and was advised to avoid all products containing lactase enzymes as an ingredient and to carry an epinephrine auto-injector.	Epinephrine	218-229	lactase	Homo sapiens	31-38
27959576-6	2016	We found modestly increased adrenal expression of Dbh in transgenic rats versus SHR non-transgenic controls that was associated with reduced adrenal levels of dopamine and increased plasma levels of norepinephrine and epinephrine.	Epinephrine	202-213	dopamine beta-hydroxylase	Rattus norvegicus	50-53
27769893-1	2016	Epinephrine is synthesised by the catecholamine biosynthetic enzyme, phenylethanolamine N-methyltransferase (PNMT), primarily in chromaffin cells of the adrenal medulla and secondarily in brainstem adrenergic neurons of the medulla oblongata.	Epinephrine	0-11	phenylethanolamine-N-methyltransferase	Rattus norvegicus	109-113
27769893-10	2016	The findings presented propose that alterations in the PNMT gene regulation in the brainstem contribute to enhanced PNMT production and epinephrine synthesis in the SHR, a genetic model of hypertension.	Epinephrine	136-147	phenylethanolamine-N-methyltransferase	Rattus norvegicus	55-59
27740870-7	2016	During hypoglycemic clamps, intracerebroventricular catalase increased glucagon and epinephrine responses to hypoglycemia, consistent with perceived lower glucose levels.	Epinephrine	84-95	catalase	Rattus norvegicus	52-60
28026807-3	2016	Sympathetic hyperactivation induced by administration of a large dose of adrenaline (4 mg/kg 60 min before analysis) was accompanied by an increase in heart and liver activities of glutathione peroxidase (GPx), catalase, AMP deaminase (AMPD), and adenosine deaminase (AD).	Epinephrine	73-83	catalase	Homo sapiens	211-219
27658936-1	2016	Aromatic l-amino acid decarboxylase (AADC) deficiency is an inborn error of monoamine neurotransmitter synthesis, which results in dopamine, serotonin, epinephrine and norepinephrine deficiencies.	Epinephrine	152-163	dopa decarboxylase	Mus musculus	0-35
27658936-1	2016	Aromatic l-amino acid decarboxylase (AADC) deficiency is an inborn error of monoamine neurotransmitter synthesis, which results in dopamine, serotonin, epinephrine and norepinephrine deficiencies.	Epinephrine	152-163	dopa decarboxylase	Mus musculus	37-41
28026807-3	2016	Sympathetic hyperactivation induced by administration of a large dose of adrenaline (4 mg/kg 60 min before analysis) was accompanied by an increase in heart and liver activities of glutathione peroxidase (GPx), catalase, AMP deaminase (AMPD), and adenosine deaminase (AD).	Epinephrine	73-83	adenosine monophosphate deaminase 1	Homo sapiens	221-234
28026807-3	2016	Sympathetic hyperactivation induced by administration of a large dose of adrenaline (4 mg/kg 60 min before analysis) was accompanied by an increase in heart and liver activities of glutathione peroxidase (GPx), catalase, AMP deaminase (AMPD), and adenosine deaminase (AD).	Epinephrine	73-83	adenosine monophosphate deaminase 1	Homo sapiens	236-240
28026807-3	2016	Sympathetic hyperactivation induced by administration of a large dose of adrenaline (4 mg/kg 60 min before analysis) was accompanied by an increase in heart and liver activities of glutathione peroxidase (GPx), catalase, AMP deaminase (AMPD), and adenosine deaminase (AD).	Epinephrine	73-83	adenosine deaminase	Homo sapiens	247-266
30193444-10	2016	The activation of peripheral CB1 receptors leads to inhibition of norepinephrine release from sympathetic terminals and epinephrine release from the adrenal glands.	Epinephrine	69-80	cannabinoid receptor 1 (brain)	Mus musculus	29-32
27491309-1	2016	Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline.	Epinephrine	269-279	tyrosine hydroxylase	Homo sapiens	0-20
27491309-1	2016	Tyrosine hydroxylase (TH), which was discovered at the National Institutes of Health (NIH) in 1964, is a tetrahydrobiopterin (BH4)-requiring monooxygenase that catalyzes the first and rate-limiting step in the biosynthesis of catecholamines (CAs), such as dopamine, noradrenaline, and adrenaline.	Epinephrine	269-279	tyrosine hydroxylase	Homo sapiens	22-24
27667649-7	2016	NHSG ZrO2-PPO sorbent provided excellent microextraction performance for catecholamines, low detection limits (5.6-9.6pM), high run-to-run reproducibility (RSD 0.6-5.1%), high desorption efficiency (95.0-99.5%) and high enrichment factors (~1480-2650) for dopamine and epinephrine, respectively, extracted from synthetic urine samples.	Epinephrine	269-280	protoporphyrinogen oxidase	Homo sapiens	10-13
27470552-7	2016	ALE showed some toxicity in Wistar rats discerned by increased ALT (Alanine transaminase), ALP (Alkaline phosphatase) activities and MDA (malondialdehyde) quantity, decreased GSH (reduced glutathione) levels without affecting the activity of the antioxidant enzymes (GPx (Gluthatione peroxidase), GR (Glutathione reductase) and GST (Glutathione-S-transferase activity)).	Epinephrine	0-3	glutathione-disulfide reductase	Rattus norvegicus	297-299
27470552-7	2016	ALE showed some toxicity in Wistar rats discerned by increased ALT (Alanine transaminase), ALP (Alkaline phosphatase) activities and MDA (malondialdehyde) quantity, decreased GSH (reduced glutathione) levels without affecting the activity of the antioxidant enzymes (GPx (Gluthatione peroxidase), GR (Glutathione reductase) and GST (Glutathione-S-transferase activity)).	Epinephrine	0-3	glutathione-disulfide reductase	Rattus norvegicus	301-322
27470552-7	2016	ALE showed some toxicity in Wistar rats discerned by increased ALT (Alanine transaminase), ALP (Alkaline phosphatase) activities and MDA (malondialdehyde) quantity, decreased GSH (reduced glutathione) levels without affecting the activity of the antioxidant enzymes (GPx (Gluthatione peroxidase), GR (Glutathione reductase) and GST (Glutathione-S-transferase activity)).	Epinephrine	0-3	hematopoietic prostaglandin D synthase	Rattus norvegicus	333-358
27511023-0	2016	The expression of thioredoxin-1 in acute epinephrine stressed mice.	Epinephrine	41-52	thioredoxin 1	Mus musculus	18-31
27511023-4	2016	In the present study, an acute stress mouse model was constructed by intraperitoneal injection of epinephrine (0.2 mg kg(-1)) for 4 h. Epinephrine treatment induced heat shock 70(Hsp70) expression in the stress responsive tissues, such as the cortex, hippocampus, thymus, and kidney.	Epinephrine	98-109	heat shock protein 1B	Mus musculus	179-184
27511023-4	2016	In the present study, an acute stress mouse model was constructed by intraperitoneal injection of epinephrine (0.2 mg kg(-1)) for 4 h. Epinephrine treatment induced heat shock 70(Hsp70) expression in the stress responsive tissues, such as the cortex, hippocampus, thymus, and kidney.	Epinephrine	135-146	heat shock protein 1B	Mus musculus	179-184
27511023-6	2016	In addition, the phosphorylation of cAMP-response element binding protein (CREB), a transcription factor of Trx-1, was increased after treatment with epinephrine.	Epinephrine	150-161	cAMP responsive element binding protein 1	Mus musculus	36-73
27511023-6	2016	In addition, the phosphorylation of cAMP-response element binding protein (CREB), a transcription factor of Trx-1, was increased after treatment with epinephrine.	Epinephrine	150-161	cAMP responsive element binding protein 1	Mus musculus	75-79
27511023-6	2016	In addition, the phosphorylation of cAMP-response element binding protein (CREB), a transcription factor of Trx-1, was increased after treatment with epinephrine.	Epinephrine	150-161	thioredoxin 1	Mus musculus	108-113
27511023-7	2016	The block of CREB activation by H89 inhibited the acute epinephrine stress-induced Trx-1 and Hsp70 expression.	Epinephrine	56-67	cAMP responsive element binding protein 1	Mus musculus	13-17
27511023-7	2016	The block of CREB activation by H89 inhibited the acute epinephrine stress-induced Trx-1 and Hsp70 expression.	Epinephrine	56-67	thioredoxin 1	Mus musculus	83-88
27511023-7	2016	The block of CREB activation by H89 inhibited the acute epinephrine stress-induced Trx-1 and Hsp70 expression.	Epinephrine	56-67	heat shock protein 1B	Mus musculus	93-98
27511023-8	2016	Taken together, our data suggest that acute stimuli of epinephrine induced Trx-1 expression through activating CREB and may represent a protective role against stress.	Epinephrine	55-66	thioredoxin 1	Mus musculus	75-80
27511023-8	2016	Taken together, our data suggest that acute stimuli of epinephrine induced Trx-1 expression through activating CREB and may represent a protective role against stress.	Epinephrine	55-66	cAMP responsive element binding protein 1	Mus musculus	111-115
27211835-1	2016	OBJECTIVE: Ischemic postconditioning (PC) using three intentional pauses at the start of cardiopulmonary resuscitation (CPR) improves outcomes after cardiac arrest in pigs when epinephrine (epi) is used before defibrillation.	Epinephrine	177-188	cytochrome p450 oxidoreductase	Sus scrofa	120-123
27541735-8	2016	Phosphorylation of beta2ARs at serine (Ser)355/356 GRK phosphorylation sites, but not at Ser345/346 PKA phosphorylation sites increased with continuous epinephrine stimulation for 60 min.	Epinephrine	152-163	G protein-coupled receptor kinase 4	Mus musculus	51-54
27541735-11	2016	Furthermore, inhibition of beta2AR dephosphorylation by okadaic acid, a phosphatase 2A inhibitor, impaired the recovery of internalized beta2ARs and reduced the cardiomyocyte contraction rate in response to epinephrine.	Epinephrine	207-218	adrenergic receptor, beta 2	Mus musculus	27-34
27618414-12	2016	CONCLUSIONS: These findings suggest that downregulation of ALDH and AKR enzymes, particularly ALDH1a1, may contribute ALE accumulation in the diabetic retina.	Epinephrine	118-121	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	59-63
27618414-12	2016	CONCLUSIONS: These findings suggest that downregulation of ALDH and AKR enzymes, particularly ALDH1a1, may contribute ALE accumulation in the diabetic retina.	Epinephrine	118-121	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	94-101
27845301-5	2016	Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gene (+2.1 times), and down-regulate the gene expression of neuregulin 1 (-3.7 times), plasminogen activator inhibitor-1 (-2.4 times) and SPARC-related modular calcium-binding protein-2 (-4.5 times).	Epinephrine	62-73	angiopoietin 2	Rattus norvegicus	135-149
27845301-5	2016	Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gene (+2.1 times), and down-regulate the gene expression of neuregulin 1 (-3.7 times), plasminogen activator inhibitor-1 (-2.4 times) and SPARC-related modular calcium-binding protein-2 (-4.5 times).	Epinephrine	62-73	neuregulin 1	Rattus norvegicus	210-222
27845301-5	2016	Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gene (+2.1 times), and down-regulate the gene expression of neuregulin 1 (-3.7 times), plasminogen activator inhibitor-1 (-2.4 times) and SPARC-related modular calcium-binding protein-2 (-4.5 times).	Epinephrine	62-73	serpin family E member 1	Rattus norvegicus	237-270
27845301-5	2016	Our investigation revealed that exposure of cardiomyocytes to epinephrine in an in vitro environment can up-regulate the expression of angiopoietin-2 gene (+2.1 times), and down-regulate the gene expression of neuregulin 1 (-3.7 times), plasminogen activator inhibitor-1 (-2.4 times) and SPARC-related modular calcium-binding protein-2 (-4.5 times).	Epinephrine	62-73	SPARC related modular calcium binding 2	Rattus norvegicus	288-335
26941040-5	2016	The selective beta1 antagonist metoprolol was able to inhibit epinephrine mediated encystment by &gt; 55%.	Epinephrine	62-73	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	14-19
27830686-9	2016	In glial and neuronal cells the adrenaline-evoked cAMP effect was mediated mainly by the beta1-adrenoceptor, whereas in tumor cells the effect was probably mediated by all three beta-subtype specific drugs.	Epinephrine	32-42	adrenoceptor beta 1	Homo sapiens	89-107
27581663-0	2016	Epinephrine pen maker offers discounts after alleged price hiking.	Epinephrine	0-11	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	12-15
26909542-1	2016	Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype.	Epinephrine	65-76	adrenergic receptor, beta 2	Mus musculus	28-46
26909542-1	2016	Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype.	Epinephrine	65-76	adrenergic receptor, beta 2	Mus musculus	48-55
26909542-1	2016	Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype.	Epinephrine	65-76	phenylethanolamine-N-methyltransferase	Mus musculus	78-116
26909542-1	2016	Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype.	Epinephrine	65-76	phenylethanolamine-N-methyltransferase	Mus musculus	118-122
26909542-1	2016	Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype.	Epinephrine	65-76	adrenergic receptor, beta 2	Mus musculus	285-292
26909542-1	2016	Mice lacking the endogenous beta2-adrenoceptor (beta2AR) agonist epinephrine (phenylethanolamine N-methyltransferase [PNMT]-knockout mice) are resistant to developing an "asthma-like" phenotype in an ovalbumin sensitization and challenge (Ova S/C) model, and chronic administration of beta2AR agonists to PNMT-KO mice restores the phenotype.	Epinephrine	65-76	phenylethanolamine-N-methyltransferase	Mus musculus	305-309
26909542-2	2016	Based on these and other studies showing differential effects of various beta2AR ligands on the asthma phenotype, we have speculated that the permissive effect of endogenous epinephrine and exogenous beta2AR agonists on allergic lung inflammation can be explained by qualitative beta2AR signaling.	Epinephrine	174-185	adrenergic receptor, beta 2	Mus musculus	73-80
26919286-2	2016	Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine.	Epinephrine	116-127	catechol-O-methyltransferase	Rattus norvegicus	0-29
26919286-2	2016	Catechol-O-methyl transferase (COMT) is a catecholamine-degrading enzyme, the substrates of which include dopamine, epinephrine, and norepinephrine.	Epinephrine	116-127	catechol-O-methyltransferase	Rattus norvegicus	31-35
27254000-5	2016	Adrenal catecholamine contents, cellular ultrastructure, and expression of phenylethanolamine N-methyltransferase, which converts norepinephrine to epinephrine, were also determined in wt and mutant rats.	Epinephrine	133-144	phenylethanolamine-N-methyltransferase	Rattus norvegicus	75-113
27154061-8	2016	RESULTS: We uncovered that adrenaline promoted DEN-induced hepatocarcinogenesis, which was reversed by the ADRB2 antagonist ICI118,551.	Epinephrine	27-37	adrenergic receptor, beta 2	Mus musculus	107-112
27166283-0	2016	AP2-NR4A3 transgenic mice display reduced serum epinephrine because of increased catecholamine catabolism in adipose tissue.	Epinephrine	48-59	fatty acid binding protein 4, adipocyte	Mus musculus	0-3
27166283-0	2016	AP2-NR4A3 transgenic mice display reduced serum epinephrine because of increased catecholamine catabolism in adipose tissue.	Epinephrine	48-59	nuclear receptor subfamily 4, group A, member 3	Mus musculus	4-9
27166283-6	2016	AP2-NR4A3 mice also display a significant reduction in serum epinephrine due to increased expression of catecholamine-catabolizing enzymes in adipose tissue, including monoamine oxidase-A.	Epinephrine	61-72	fatty acid binding protein 4, adipocyte	Mus musculus	0-3
27166283-6	2016	AP2-NR4A3 mice also display a significant reduction in serum epinephrine due to increased expression of catecholamine-catabolizing enzymes in adipose tissue, including monoamine oxidase-A.	Epinephrine	61-72	nuclear receptor subfamily 4, group A, member 3	Mus musculus	4-9
27166283-8	2016	Finally, AP2-NR4A3 mice display cardiac and behavioral alterations consistent with chronically low circulating epinephrine levels.	Epinephrine	111-122	fatty acid binding protein 4, adipocyte	Mus musculus	9-12
27166283-8	2016	Finally, AP2-NR4A3 mice display cardiac and behavioral alterations consistent with chronically low circulating epinephrine levels.	Epinephrine	111-122	nuclear receptor subfamily 4, group A, member 3	Mus musculus	13-18
27560796-7	2016	Induction of non-sympathetical catecholamine production was observed 7 days after cold exposure by elevated TH and phenylethanolamine-N-methyltransferase (PNMT) expression, leading to an increased epinephrine levels.	Epinephrine	197-208	phenylethanolamine-N-methyltransferase	Rattus norvegicus	115-153
27560796-7	2016	Induction of non-sympathetical catecholamine production was observed 7 days after cold exposure by elevated TH and phenylethanolamine-N-methyltransferase (PNMT) expression, leading to an increased epinephrine levels.	Epinephrine	197-208	phenylethanolamine-N-methyltransferase	Rattus norvegicus	155-159
27221021-2	2016	The beta2-adrenoceptor mediated effects during development might be linked to the increase of epinephrine synthesis.	Epinephrine	94-105	adrenoceptor beta 2	Homo sapiens	4-22
27221021-13	2016	We conclude that epinephrine may influence the development of the beta2-adrenoceptor-mediated responses at birth and the rabbit is an excellent model to study these issues.	Epinephrine	17-28	adrenoceptor beta 2	Homo sapiens	66-84
26935743-2	2016	Insulin (1 and 10 U/kg) treatment caused similar reductions in blood glucose concentration (from 7.5-9 to 2-3 mmol/L); however, plasma adrenaline concentration was increased 20-30 fold in response to 10 U/kg insulin and only 14 fold following 1 U/kg.	Epinephrine	135-145	insulin 1	Rattus norvegicus	0-17