PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21035736-0	2010	hCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation.	biarylpyrazole	65-79	cannabinoid receptor 2	Homo sapiens	0-4
23066093-0	2013	The biarylpyrazole compound AM251 alters mitochondrial physiology via proteolytic degradation of ERRalpha.	biarylpyrazole	4-18	estrogen related receptor alpha	Homo sapiens	97-105
23066093-2	2013	A crucial role for controlling ERRalpha-mediated target gene expression has been ascribed to the biarylpyrazole compound 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide (AM251) through direct binding to and destabilization of ERRalpha protein.	biarylpyrazole	97-111	estrogen related receptor alpha	Homo sapiens	31-39
23066093-2	2013	A crucial role for controlling ERRalpha-mediated target gene expression has been ascribed to the biarylpyrazole compound 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide (AM251) through direct binding to and destabilization of ERRalpha protein.	biarylpyrazole	97-111	estrogen related receptor alpha	Homo sapiens	269-277
18954042-2	2008	In the present study, biarylpyrazole analogues based on a pyrazole core coupled with 1,3,4-oxadiazole were synthesized and tested for CB1 receptor binding affinity.	biarylpyrazole	22-36	cannabinoid receptor 1	Homo sapiens	134-137
17004712-0	2006	Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.	biarylpyrazole	0-14	cannabinoid receptor 1	Homo sapiens	51-54
17004712-0	2006	Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.	biarylpyrazole	0-14	complement C3	Homo sapiens	83-86
17004712-1	2006	The biarylpyrazole, N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716; 1) has been shown to act as an inverse agonist/antagonist at the cannabinoid CB1 receptor.	biarylpyrazole	4-18	cannabinoid receptor 1	Homo sapiens	204-207
17004712-5	2006	(1) These results suggested a relationship between biarylpyrazole interaction with K3.28(192) at CB1 and inverse agonism, but these results were for a single pair of compounds (1 and 2).	biarylpyrazole	51-65	cannabinoid receptor 1	Homo sapiens	97-100
21426091-2	2009	DISCUSSION: In the present study, biarylpyrazole analogues based on a sulfur-containing pyrazole core coupled with 1,3,4-oxadiazole and 1,3,4-thiadiazole were synthesized and assayed for rat CB1 receptor binding affinity.	biarylpyrazole	34-48	cannabinoid receptor 1	Rattus norvegicus	191-194
10072686-13	1999	Of these, (-)-Delta8-THC and SR141716A, a biarylpyrazole CB1 antagonist, were found to inhibit enzymatic activity.	biarylpyrazole	42-56	cannabinoid receptor 1	Rattus norvegicus	57-60