PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7344487-0	1981	Benzil, a selective inducer and a potent in vitro activator of microsomal epoxide hydrolase.	benzil	0-6	epoxide hydrolase 1	Homo sapiens	63-91
3758069-0	1986	The effects of metyrapone, chalcone epoxide, benzil, clotrimazole and related compounds on the activity of microsomal epoxide hydrolase in situ, in purified form and in reconstituted systems towards different substrates.	benzil	45-51	epoxide hydrolase 1	Rattus norvegicus	107-135
3758069-1	1986	The influence of metyrapone, chalcone epoxide, benzil and clotrimazole on the activity of microsomal epoxide hydrolase towards styrene oxide, benzo[a]pyrene 4,5-oxide, estroxide and androstene oxide was investigated.	benzil	47-53	epoxide hydrolase 1	Rattus norvegicus	90-118
7213812-5	1981	In addition, epoxide hydrolase and glutathione S-transferase activities were induced by benzoin and benzil.	benzil	100-106	hematopoietic prostaglandin D synthase	Rattus norvegicus	35-60
3621371-4	1987	Cytosolic epoxide hydrolase activity was induced by chlorinated paraffins, di(2-ethylhexyl)phthalate and clofibrate and depressed by alpha-naphthylisothiocyanate, 3-methylcholanthrene, benzil and quercitin.	benzil	185-191	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-27
7460941-0	1980	Benzil, a potent activator of microsomal epoxide hydrolase in vitro.	benzil	0-6	epoxide hydrolase 1	Rattus norvegicus	30-58
7460941-1	1980	Benzil was found to be a very potent activator of microsomal epoxide hydrolase activity (measured with styrene oxide as substrate) in vitro.	benzil	0-6	epoxide hydrolase 1	Rattus norvegicus	50-78
7460941-5	1980	In order to obtain indications for the existence of more than one microsomal epoxide hydrolase the effect of benzil on this activity from rats induced with phenobarbital, 3-methylcholanthrene, 2-acetylaminofluorene, trans-stilbene oxide, and benzil was tested.	benzil	109-115	epoxide hydrolase 1	Rattus norvegicus	66-94
28687384-4	2017	Three novel substrates of DHRS7 (dihydrotestosterone, benzil and 4,4"-dimetylbenzil) have been described.	benzil	54-60	dehydrogenase/reductase 7	Homo sapiens	26-31
29944353-9	2018	With benzil complex 6 underwent a 1,4-addition reaction to afford a cis-enediolate which was coordinated to the Sc/P FLP through Sc-O and P-O bonds.	benzil	5-11	DELYQ11	Homo sapiens	129-141
30773431-3	2019	Here, we report a highly sensitive off/on-type fluorescence probe for PAD activity based on the donor-excited photoinduced electron transfer (d-PeT) mechanism, utilizing the specific cycloaddition reaction between the benzil group of the probe and the ureido group of the PAD product, citrulline, under acidic conditions.	benzil	218-224	peptidyl arginine deiminase 4	Homo sapiens	70-73
30773431-3	2019	Here, we report a highly sensitive off/on-type fluorescence probe for PAD activity based on the donor-excited photoinduced electron transfer (d-PeT) mechanism, utilizing the specific cycloaddition reaction between the benzil group of the probe and the ureido group of the PAD product, citrulline, under acidic conditions.	benzil	218-224	peptidyl arginine deiminase 4	Homo sapiens	272-275
29316108-2	2018	In contrast, treatment of c-Si3 Tip4 (Tip=2,4,6-i Pr3 C6 H2 ) with styrene and benzil results in ring opening of the three-membered ring to formally yield the [1+2]- and [1+4] cycloaddition product of the isomeric disilenyl silylene to the C=C bond and the 1,2-diketone pi system, respectively.	benzil	79-85	GIPC PDZ domain containing family member 1	Homo sapiens	38-43
27343379-9	2016	Simvastatin suppressed IL-5 and IL-13 in Th2-cells co-cultivated with monocytes or AM, which was partially reversed by the carboxylesterase inhibitor benzil.	benzil	150-156	interleukin 5	Homo sapiens	23-27
27725279-1	2016	Mononuclear transition metal complexes of Cu(II), Co(II) and Ni(II) with a newly synthesised macrocyclic ligand derived from 1, 4-dicarbonyl-phenyl-dihydrazide and 1,2-diphenylethane-1,2-dione (2:2) have been synthesised.	benzil	164-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-56
27343379-9	2016	Simvastatin suppressed IL-5 and IL-13 in Th2-cells co-cultivated with monocytes or AM, which was partially reversed by the carboxylesterase inhibitor benzil.	benzil	150-156	interleukin 13	Homo sapiens	32-37
25462626-1	2015	A new and efficient solvent free synthesis of 2,4,5-trisubstituted imidazoles (3a-3j) was achieved by N-acetyl glycine (NAG) catalyzed three components condensation of aldehydes, benzil and ammonium acetate.	benzil	179-185	N-acetyl-alpha-glucosaminidase	Homo sapiens	102-118
25462626-1	2015	A new and efficient solvent free synthesis of 2,4,5-trisubstituted imidazoles (3a-3j) was achieved by N-acetyl glycine (NAG) catalyzed three components condensation of aldehydes, benzil and ammonium acetate.	benzil	179-185	N-acetyl-alpha-glucosaminidase	Homo sapiens	120-123
22085648-6	2012	Benzil and bis-p-nitrophenyl phosphate (BNPP), two carboxylesterase inhibitors, abrogated the effect of carboxylesterases and resensitized carboxylesterase-expressing cells to the potent cytotoxic effects of phospho-NSAIDs.	benzil	0-6	carboxylesterase 1	Homo sapiens	104-121
18477509-1	2008	A series of benzil derivatives related to combretastatin A-4 (CA-4) have been synthesized by oxidation of diarylalkynes promoted by PdI(2) in DMSO.	benzil	12-18	carbonic anhydrase 4	Homo sapiens	42-60
19062296-7	2009	CoMFA-based models for the benzil-analogs described 88%, 95% and 76% of observed activity for hiCE, hCE1 and rCE, respectively.	benzil	27-33	carboxylesterase 1	Homo sapiens	100-104
19062296-10	2009	A comprehensive model incorporating both benzil and TFK structures described 92%, 85% and 87% of observed activity for hiCE, hCE1 and rCE, respectively.	benzil	41-47	carboxylesterase 1	Homo sapiens	125-129
19056333-3	2009	We have found that pig, rabbit and dog DHRS4s reduce benzil and 3-ketosteroids into S-benzoin and 3alpha-hydroxysteroids, respectively, in contrast to the stereoselectivity of human DHRS4 which produces R-benzoin and 3beta-hydroxysteroids.	benzil	53-59	dehydrogenase/reductase SDR family member 4	Canis lupus familiaris	39-44
18477509-1	2008	A series of benzil derivatives related to combretastatin A-4 (CA-4) have been synthesized by oxidation of diarylalkynes promoted by PdI(2) in DMSO.	benzil	12-18	carbonic anhydrase 4	Homo sapiens	62-66
18023188-4	2008	The selective carboxylesterase inhibitor benzil was used as a non-TFK containing control.	benzil	41-47	carboxylesterase 1	Homo sapiens	14-30
16985062-4	2006	We have recently identified two classes of carboxylesterase inhibitors based on either a benzil (diphenylethane-1,2-dione) or a benzene sulfonamide scaffold and showed that these compounds inhibit carboxylesterases with Kis in the low nanomolar range.	benzil	89-95	U2AF homology motif kinase 1	Homo sapiens	220-223
16985062-4	2006	We have recently identified two classes of carboxylesterase inhibitors based on either a benzil (diphenylethane-1,2-dione) or a benzene sulfonamide scaffold and showed that these compounds inhibit carboxylesterases with Kis in the low nanomolar range.	benzil	97-121	U2AF homology motif kinase 1	Homo sapiens	220-223
16985062-7	2006	These studies show that benzil and a dimethylbenzil analogue efficiently enter cells and inhibit human intestinal carboxylesterase and rabbit liver carboxylesterase intracellularly.	benzil	24-30	liver carboxylesterase 1	Oryctolagus cuniculus	142-164
16081098-0	2005	Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.	benzil	111-117	carboxylesterase 1	Homo sapiens	50-68
16081098-2	2005	We present and analyze crystal structures of hCE1 in complexes with the cholesterol-lowering drug mevastatin, the breast cancer drug tamoxifen, the fatty acyl ethyl ester (FAEE) analogue ethyl acetate, and the novel hCE1 inhibitor benzil.	benzil	231-237	carboxylesterase 1	Homo sapiens	45-49