PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2888915-2 1987 The inhibition was shown to be specific and competitive with PAF on its receptor by the following observations: parallel shift of the dose-response curve; crossing of double reciprocal plots on the intersection of the ordinate; and no inhibition on other autacoids such as bradykinin, histamine, 5-hydroxytryptamine and LTC4. Leukotriene C4 320-324 PCNA clamp associated factor Rattus norvegicus 61-64 3094005-2 1986 Pretreatment of these cells with the pertussis toxin islet-activating protein (IAP) results in a dose-dependent inhibition of the release of arachidonic acid metabolites and prostacyclin in response to leukotriene D4 and leukotriene C4. Leukotriene C4 221-235 CD47 molecule Bos taurus 53-77 3117020-0 1987 [Effect of catalase on leukotriene C4 release from eosinophils, neutrophils or monocytes and a possible involvement of cell to cell interaction in the release process]. Leukotriene C4 23-37 catalase Homo sapiens 11-19 3095427-2 1986 Here we show that purified biosynthetic (recombinant) human T lymphocyte granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced markedly two eosinophil functions: cytotoxicity toward schistosomula by a mean of 676%, and calcium ionophore A23187-induced generation of leukotriene C4 (LTC4) by a mean of 135%. Leukotriene C4 279-293 colony stimulating factor 2 Homo sapiens 73-121 3095427-2 1986 Here we show that purified biosynthetic (recombinant) human T lymphocyte granulocyte-macrophage colony-stimulating factor (GM-CSF) enhanced markedly two eosinophil functions: cytotoxicity toward schistosomula by a mean of 676%, and calcium ionophore A23187-induced generation of leukotriene C4 (LTC4) by a mean of 135%. Leukotriene C4 279-293 colony stimulating factor 2 Homo sapiens 123-129 3032266-1 1987 The effects of an inhalation anesthetic, halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) on the formation of 5-lipoxygenase metabolites such as leukotriene B4, 5(S)-hydroxyeicosatetraenoic acid (5-HETE), 6-trans-isomers of leukotriene B4 and leukotriene C4 were studied in human leukocytes stimulated with calcium ionophore A23187. Leukotriene C4 245-259 arachidonate 5-lipoxygenase Homo sapiens 112-126 3094005-2 1986 Pretreatment of these cells with the pertussis toxin islet-activating protein (IAP) results in a dose-dependent inhibition of the release of arachidonic acid metabolites and prostacyclin in response to leukotriene D4 and leukotriene C4. Leukotriene C4 221-235 CD47 molecule Bos taurus 79-82 3549770-2 1986 The secretory activity of the arachidonate metabolite leukotriene C4 (LTC4) was biphasic and 10-fold more potent than that of the physiological stimulus gonadotrophin-releasing hormone (GnRH). Leukotriene C4 54-68 gonadotropin releasing hormone 1 Rattus norvegicus 153-184 2872925-4 1986 Verification of leukotriene C4 formation was obtained by conversion into leukotriene D4 during reaction of the HPLC-purified platelet-derived leukotriene C4 with commercial gamma-glutamyl transpeptidase. Leukotriene C4 16-30 inactive glutathione hydrolase 2 Homo sapiens 173-202 2872925-5 1986 In separate experiments we incubated authentic tritiated leukotriene C4 with human platelets and we showed the formation of tritiated leukotriene D4, demonstrating the presence of gamma-glutamyl transpeptidase activity in these cells. Leukotriene C4 57-71 inactive glutathione hydrolase 2 Homo sapiens 180-209 3089952-0 1986 Cyclooxygenase inhibitors promote the leukotriene C4 induced release of beta-glucuronidase from rat peritoneal macrophages: prostaglandin E2 suppresses. Leukotriene C4 38-52 glucuronidase, beta Rattus norvegicus 72-90 3485946-4 1986 The optimal concentration of anti-IgE for the release of the arachidonate cyclooxygenase metabolites PGD2 and TxB2 (0.3 microgram/ml) was 10- to 30-fold less than that required for the release of histamine and LTC4 (3 to 10 micrograms/ml), suggesting that these release processes may have differential IgE Fc receptor cross-linking requirements. Leukotriene C4 210-214 prostaglandin D2 synthase Homo sapiens 101-105 3003083-6 1986 Nanomolar amounts of leukotriene C4 (LTC4), relative to millimolar concentrations of substrate, inhibited eosinophil arylsulfatase B. Leukotriene C4 21-35 arylsulfatase B Homo sapiens 117-132 3082323-1 1986 Resident mouse peritoneal macrophages when exposed to zymosan during the first day of cell culture synthesize and secrete large amounts of prostaglandin E2 (PGE2) and leukotriene C4 (LTC4), the respective products of cyclo-oxygenase- and 5-lipoxygenase-catalysed oxygenations of arachidonic acid. Leukotriene C4 183-187 arachidonate 5-lipoxygenase Mus musculus 238-252 3007577-6 1986 The inhibition of lymphocyte proliferation by either hydrocortisone or by the 5-lipoxygenase inhibitor was totally reversed by LTB4 but not by leukotriene C4 or leukotriene D4. Leukotriene C4 143-157 arachidonate 5-lipoxygenase Homo sapiens 78-92 2869956-0 1986 Leukotriene C4 is a potent stimulator of LHRH secretion. Leukotriene C4 0-14 gonadotropin releasing hormone 1 Homo sapiens 41-45 3089952-2 1986 Leukotriene C4 enhanced the release of beta-glucuronidase as well as the production of prostaglandin E2. Leukotriene C4 0-14 glucuronidase, beta Rattus norvegicus 39-57 3001181-5 1986 Resolution by reverse phase high performance liquid chromatography of the products released from monocytes pretreated with cytochalasin B and stimulated with FMLP or calcium ionophore yielded a single peak of immunoreactive LTB4 eluting at the same retention time as the synthetic standard; immunoreactive C-6 sulfidopeptide leukotrienes eluted at the retention times of leukotriene C4 (LTC4) and leukotriene D4 (LTD4). Leukotriene C4 371-385 formyl peptide receptor 1 Homo sapiens 158-162 3547000-7 1986 As leukotriene C4 is a potent gastric vasoconstrictor, increased metabolism of arachidonic acid via the 5-lipoxygenase pathway in the presence of inhibition of cyclo-oxygenase could possibly contribute to drug-induced gastrointestinal damage. Leukotriene C4 3-17 arachidonate 5-lipoxygenase Homo sapiens 104-118 3932580-1 1985 Freshly isolated 2-h adherent normal human monocytes, when stimulated, degrade added leukotriene C4 (LTC4) by a myeloperoxidase (MPO) and H2O2-dependent mechanism. Leukotriene C4 85-99 myeloperoxidase Homo sapiens 112-127 3932580-1 1985 Freshly isolated 2-h adherent normal human monocytes, when stimulated, degrade added leukotriene C4 (LTC4) by a myeloperoxidase (MPO) and H2O2-dependent mechanism. Leukotriene C4 85-99 myeloperoxidase Homo sapiens 129-132 2987949-5 1985 Furthermore, the LH-releasing ability of leukotriene C4 was blocked in the presence of high doses of LHRH. Leukotriene C4 41-55 gonadotropin releasing hormone 1 Rattus norvegicus 101-105 2992598-3 1985 The identity of leukotriene C4 was confirmed through enzymatic conversion into D4 by gamma-glutamyl transpeptidase as well as by bioassay on the rat stomach fundus after HPLC purification. Leukotriene C4 16-30 gamma-glutamyltransferase 1 Rattus norvegicus 85-114 6151905-0 1984 Beta 2-adrenoceptor agonists reverse the leukotriene C4-induced release response of macrophages. Leukotriene C4 41-55 adrenoceptor beta 2 Rattus norvegicus 0-19 3922966-2 1985 Particulate agonists, zymosan and latex, stimulated the production of cyclooxygenase metabolites as well as the 5-lipoxygenase product, leukotriene C4. Leukotriene C4 136-150 arachidonate 5-lipoxygenase Mus musculus 112-126 3922966-8 1985 Presumably, calcium ionophore unmasked the synthesis of leukotriene C4 from phorbol myristate acetate-released and exogenous arachidonate by elevating intracellular calcium levels enough for 5-lipoxygenase activation. Leukotriene C4 56-70 arachidonate 5-lipoxygenase Mus musculus 191-205 2988021-1 1985 We showed previously that polyenoic fatty acids with double bonds at carbon 5,8,11 are good substrates for the 5-lipoxygenase and also can be converted to LTC and dihydroxy acids. Leukotriene C4 155-158 arachidonate 5-lipoxygenase Rattus norvegicus 111-125 6151716-5 1984 The membrane fraction contained the enzymes gamma-glutamyl transpeptidase and amino peptidase which convert LTC4 to LTD4 and LTD4 to LTE4, respectively. Leukotriene C4 108-112 gamma-glutamyltransferase 1 Rattus norvegicus 44-73 6330206-3 1984 The released products of the 5-lipoxygenase pathway were quantitated by integrated ultraviolet absorbance after resolution by reverse phase-high performance liquid chromatography in the case of 5-hydroxy-eicosatetraenoic acid (5-HETE), and by separate radioimmunoassays for leukotriene C4 (LTC4) and leukotriene B4 (LTB4). Leukotriene C4 274-288 arachidonate 5-lipoxygenase Mus musculus 29-43 6149445-0 1984 Discriminative effect of gamma-glutamyl transpeptidase inhibitors on metabolism of leukotriene C4 in peritoneal cells. Leukotriene C4 83-97 gamma-glutamyltransferase 1 Rattus norvegicus 25-54 6330206-3 1984 The released products of the 5-lipoxygenase pathway were quantitated by integrated ultraviolet absorbance after resolution by reverse phase-high performance liquid chromatography in the case of 5-hydroxy-eicosatetraenoic acid (5-HETE), and by separate radioimmunoassays for leukotriene C4 (LTC4) and leukotriene B4 (LTB4). Leukotriene C4 290-294 arachidonate 5-lipoxygenase Mus musculus 29-43 6317747-3 1984 The suppression was significantly reversed by leukotriene C4, which further suggests that leukotrienes and possibly other substances produced by the lipoxygenase pathway of arachidonic acid metabolism play an important role in the regulation of IFN gamma production. Leukotriene C4 46-60 interferon gamma Mus musculus 245-254 6722998-4 1984 Leukotriene C4 also resulted in an average loss of 20% in plasma volume which, during the postinfusion period, perpetuated the low cardiac output state and thus provoked the release of angiotensin II. Leukotriene C4 0-14 angiotensinogen Rattus norvegicus 185-199 7139193-0 1982 The effect of leukotriene C4 on mucin release into the cat trachea in vivo and in vitro. Leukotriene C4 14-28 LOC100508689 Homo sapiens 32-37 6324182-0 1983 Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4. Leukotriene C4 113-127 arachidonate 5-lipoxygenase Homo sapiens 29-43 6324182-1 1983 5-Lipoxygenase pathway-derived products of arachidonic acid released by human eosinophils activated in vitro have been measured by using radioimmunoassays specific for leukotriene B4 (LTB4) and for sulfidopeptide leukotrienes including leukotriene C4 (LTC4). Leukotriene C4 236-250 arachidonate 5-lipoxygenase Homo sapiens 0-14 6285918-0 1982 The conversion of leukotriene C4 to isomers of leukotriene B4 by human eosinophil peroxidase. Leukotriene C4 18-32 eosinophil peroxidase Homo sapiens 71-92 6122208-3 1982 Because gamma-glutamyl transpeptidase is bound to the external surface of cell membranes and thus is readily accessible to plasma amino acids, it appears that conversion of leukotriene C4 to leukotriene D4 under physiological conditions is coupled with the formation of gamma-glutamyl amino acids. Leukotriene C4 173-187 inactive glutathione hydrolase 2 Homo sapiens 8-37 6120989-6 1982 In contrast, PAM produced leukotrienes D and E in addition to leukotriene C, prostaglandin E2, thromboxane A2, and hydroxyeicosatetraenoic acids. Leukotriene C4 62-75 peptidylglycine alpha-amidating monooxygenase Mus musculus 13-16 6122208-5 1982 Conversion of leukotriene D4 to leukotriene C4 is effectively catalyzed by gamma-glutamyl transpeptidase in the presence of relatively low concentrations of glutathione. Leukotriene C4 32-46 inactive glutathione hydrolase 2 Homo sapiens 75-104 34012562-11 2021 Further investigation is needed to characterize the long-term efficacy of LINX implantation after LTx. Leukotriene C4 98-101 immunoglobulin superfamily containing leucine rich repeat 2 Homo sapiens 74-78 6106018-4 1980 The results demonstrate that gamma-glutamyl transpeptidase is involved in the biosynthesis of leukotriene D4 and suggest that leukotriene C4 is formed as an intermediate. Leukotriene C4 126-140 gamma-glutamyltransferase 1 Rattus norvegicus 29-58 33469960-4 2021 To the end, we first construct an inward-facing state of hMRP1 using homology modeling method, and then dock substrate proinflammatory agent leukotriene C4 (LTC4) to hMRP1 pocket. Leukotriene C4 141-155 ATP binding cassette subfamily C member 1 Homo sapiens 57-62 33469960-4 2021 To the end, we first construct an inward-facing state of hMRP1 using homology modeling method, and then dock substrate proinflammatory agent leukotriene C4 (LTC4) to hMRP1 pocket. Leukotriene C4 141-155 ATP binding cassette subfamily C member 1 Homo sapiens 166-171 33741927-1 2021 Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C4, key for intracrine signaling of endoplasmic reticulum (ER) stress, oxidative DNA damage and cell death. Leukotriene C4 56-70 microsomal glutathione S-transferase 2 Homo sapiens 0-38 33753496-6 2021 Injection of leukotriene C4 (LTC4) or its nonhydrolyzable form NMLTC4, but neither LTD4 nor LTE4, induced dose-dependent itch but not pain behaviors in mice. Leukotriene C4 13-27 itchy, E3 ubiquitin protein ligase Mus musculus 121-125 33753496-6 2021 Injection of leukotriene C4 (LTC4) or its nonhydrolyzable form NMLTC4, but neither LTD4 nor LTE4, induced dose-dependent itch but not pain behaviors in mice. Leukotriene C4 29-33 itchy, E3 ubiquitin protein ligase Mus musculus 121-125 33741927-1 2021 Microsomal glutathione S-transferase 2 (MGST2) produces leukotriene C4, key for intracrine signaling of endoplasmic reticulum (ER) stress, oxidative DNA damage and cell death. Leukotriene C4 56-70 microsomal glutathione S-transferase 2 Homo sapiens 40-45 33537146-3 2021 In this case report, we describe progressive allograft dysfunction following LTx for COPA-ILD. Leukotriene C4 77-80 COPI coat complex subunit alpha Homo sapiens 85-89 32749698-11 2021 These findings suggest that the BATF/JUN/IRF4 complex-IL-21 axis may be used as a potential target for attenuating rejection injury after LTx. Leukotriene C4 138-141 interleukin 21 Rattus norvegicus 54-59 32749698-4 2021 This study aimed to explore the role of the BATF/JUN/IRF4 complex in rejection after LTx by treatment with Tac. Leukotriene C4 85-88 basic leucine zipper ATF-like transcription factor Rattus norvegicus 44-48 32749698-4 2021 This study aimed to explore the role of the BATF/JUN/IRF4 complex in rejection after LTx by treatment with Tac. Leukotriene C4 85-88 interferon regulatory factor 4 Rattus norvegicus 53-57 32749698-11 2021 These findings suggest that the BATF/JUN/IRF4 complex-IL-21 axis may be used as a potential target for attenuating rejection injury after LTx. Leukotriene C4 138-141 basic leucine zipper ATF-like transcription factor Rattus norvegicus 32-36 32749698-11 2021 These findings suggest that the BATF/JUN/IRF4 complex-IL-21 axis may be used as a potential target for attenuating rejection injury after LTx. Leukotriene C4 138-141 interferon regulatory factor 4 Rattus norvegicus 41-45 33537146-9 2021 Results: Multiplexed cytokine analysis showed rising type I/II IFNs, and IL-6 in BAL post-LTx that decreased following treatment of acute rejection but rebounded with further clinical deterioration. Leukotriene C4 90-93 interleukin 6 Homo sapiens 73-77 33142943-6 2020 Persistent elevated levels of DLL1 on day 7 and afterward following LTX were able to indicate patients at risk for a complicated course. Leukotriene C4 68-71 delta like canonical Notch ligand 1 Homo sapiens 30-34 33142943-7 2020 Plasma levels of DLL1 following LTX may be useful to support an earlier detection of bacterial infections in combination with C-reactive protein (CRP) and procalcitonin (PCT), or they may lead to risk stratification of patients as a single marker for post-operative complications. Leukotriene C4 32-35 delta like canonical Notch ligand 1 Homo sapiens 17-21 32659517-7 2020 Further, mammalian specific homolog Orai3 forms heteromultimeric channel with Orai1 for constituting Arachidonic acid regulated Ca2+ (ARC) channels or arachidonic acid metabolite Leukotriene C4 (LTC4) regulated Ca2+ (LRC) channels. Leukotriene C4 179-193 ORAI calcium release-activated calcium modulator 3 Homo sapiens 36-41 32659517-7 2020 Further, mammalian specific homolog Orai3 forms heteromultimeric channel with Orai1 for constituting Arachidonic acid regulated Ca2+ (ARC) channels or arachidonic acid metabolite Leukotriene C4 (LTC4) regulated Ca2+ (LRC) channels. Leukotriene C4 179-193 ORAI calcium release-activated calcium modulator 1 Homo sapiens 78-83 32314828-3 2020 METHODS: We performed a post-hoc analysis of 166 HCV+ SiLVER Study patients regarding HCC outcome after LTx. Leukotriene C4 104-107 HCC Homo sapiens 86-89 32307149-9 2020 The present results introduce the cytokines IL-6 and IL-10 in patients before and after LTx. Leukotriene C4 88-91 interleukin 6 Homo sapiens 44-48 32307149-9 2020 The present results introduce the cytokines IL-6 and IL-10 in patients before and after LTx. Leukotriene C4 88-91 interleukin 10 Homo sapiens 53-58 32307149-10 2020 The procedure of LTx influenced increasing of plasma concentration of IL-10. Leukotriene C4 17-20 interleukin 10 Homo sapiens 70-75 32814764-4 2020 We previously reported that leukotriene C4 (LTC4)-induced differentiation in colon cancer via CysLT2R signalling. Leukotriene C4 28-42 cysteinyl leukotriene receptor 2 Homo sapiens 94-101 32814764-4 2020 We previously reported that leukotriene C4 (LTC4)-induced differentiation in colon cancer via CysLT2R signalling. Leukotriene C4 44-48 cysteinyl leukotriene receptor 2 Homo sapiens 94-101 31268744-0 2019 Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1). Leukotriene C4 32-46 ATP binding cassette subfamily B member 1 Homo sapiens 69-99 32375243-6 2020 gp120 also caused the de novo synthesis of cysteinyl leukotriene C4 (LTC4) and prostaglandin D2 (PGD2) from HLMCs. Leukotriene C4 69-73 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 0-5 32165607-9 2020 Furthermore, hepatic angiopoietin-2 expression was associated with graft rejection after LTX (p<0.05). Leukotriene C4 89-92 angiopoietin 2 Homo sapiens 21-35 31783259-2 2020 A number of activators including interleukin 3 (IL-3) and IgE have been identified in the regulation of human basophils expressing mediators such as histamine and leukotriene C4 (LTC4) and cytokines, including IL-4 and IL-13. Leukotriene C4 163-177 interleukin 3 Homo sapiens 33-52 31783259-2 2020 A number of activators including interleukin 3 (IL-3) and IgE have been identified in the regulation of human basophils expressing mediators such as histamine and leukotriene C4 (LTC4) and cytokines, including IL-4 and IL-13. Leukotriene C4 179-183 interleukin 3 Homo sapiens 33-52 31783259-2 2020 A number of activators including interleukin 3 (IL-3) and IgE have been identified in the regulation of human basophils expressing mediators such as histamine and leukotriene C4 (LTC4) and cytokines, including IL-4 and IL-13. Leukotriene C4 179-183 interleukin 4 Homo sapiens 210-214 31783259-2 2020 A number of activators including interleukin 3 (IL-3) and IgE have been identified in the regulation of human basophils expressing mediators such as histamine and leukotriene C4 (LTC4) and cytokines, including IL-4 and IL-13. Leukotriene C4 179-183 interleukin 13 Homo sapiens 219-224 31268744-0 2019 Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1). Leukotriene C4 32-46 ATP binding cassette subfamily B member 1 Homo sapiens 101-105 31268744-0 2019 Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1). Leukotriene C4 32-46 ATP binding cassette subfamily C member 1 Homo sapiens 107-112 31268744-1 2019 The human multidrug resistance protein 1 (hMRP1) transporter is implicated in cancer multidrug resistance as well as immune responses involving its physiologic substrate, glutathione (GSH)-conjugated leukotriene C4 (LTC4). Leukotriene C4 200-214 ATP binding cassette subfamily B member 1 Homo sapiens 10-40 31268744-1 2019 The human multidrug resistance protein 1 (hMRP1) transporter is implicated in cancer multidrug resistance as well as immune responses involving its physiologic substrate, glutathione (GSH)-conjugated leukotriene C4 (LTC4). Leukotriene C4 200-214 ATP binding cassette subfamily C member 1 Homo sapiens 42-47 31241521-2 2019 However, there is limited literature on the benefit of PR post-LTx. Leukotriene C4 63-66 transmembrane protein 37 Homo sapiens 55-57 31289357-9 2019 Preemptive NSP reduction by CatC inhibition may prove to be a viable and effective approach to reduce immediate ischemia reperfusion responses after LTx. Leukotriene C4 149-152 reticulon 1 Mus musculus 11-14 31289357-9 2019 Preemptive NSP reduction by CatC inhibition may prove to be a viable and effective approach to reduce immediate ischemia reperfusion responses after LTx. Leukotriene C4 149-152 cathepsin C Mus musculus 28-32 31241521-3 2019 The aim of this study was to investigate the efficacy of an outpatient, multidisciplinary, comprehensive PR program in bilateral LTx recipients in the early period after LTx. Leukotriene C4 129-132 transmembrane protein 37 Homo sapiens 105-107 31241521-12 2019 CONCLUSION: This study demonstrated that patients who attended PR within 3 mo of bilateral LTx showed improvements in exercise capacity, respiratory muscle strength, quality of life, body composition, and psychological status. Leukotriene C4 91-94 transmembrane protein 37 Homo sapiens 63-65 31249568-7 2019 The FCGR3A [158V/V] genotype was identified as an independent susceptibility factor associated with higher rates of AR during the first trimester after LTx (HR 4.8, p < 0.0001, 95% CI 2.37-9.61), but it could not be associated with the level of CD16- mediated NK cell activation in response to the LTR"s DSA, whatever the MFI intensity and C1q binding profiles of the DSA evaluated. Leukotriene C4 152-155 Fc gamma receptor IIIa Homo sapiens 4-10 29929811-13 2019 CONCLUSIONS: LTX and liver resections due to CD/CS are rare and associated with an acceptable post-operative morbidity and low mortality. Leukotriene C4 13-16 citrate synthase Homo sapiens 45-50 30676521-11 2019 Insulin levels decreased significantly in the first 4 years post-LTx, but no changes in lipid panel, A1C and glucose were noted over 10 years. Leukotriene C4 65-68 insulin Homo sapiens 0-7 30664709-3 2019 Leukotriene C4 (LTC4) induces surface HMGB1 expression by mouse platelets in a CysLT2R-dependent manner. Leukotriene C4 0-14 high mobility group box 1 Mus musculus 38-43 30664709-3 2019 Leukotriene C4 (LTC4) induces surface HMGB1 expression by mouse platelets in a CysLT2R-dependent manner. Leukotriene C4 0-14 cysteinyl leukotriene receptor 2 Mus musculus 79-86 30389631-2 2019 5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4). Leukotriene C4 119-133 arachidonate 5-lipoxygenase Homo sapiens 0-5 30735559-3 2019 We combined single molecule localization microscopy with Clus-DoC cluster analysis, and also a novel unbiased cluster analysis to analyze changes in the relationships between 5-LO and FLAP in response to activation of RBL-2H3 cells to generate leukotriene C4. Leukotriene C4 244-258 RB transcriptional corepressor like 2 Rattus norvegicus 218-223 30705675-3 2018 Taking into consideration the contribution of autoimmunity to LTx outcome, we hypothesized that polymorphisms in the PTPN22 gene could be associated with BOS incidence. Leukotriene C4 62-65 protein tyrosine phosphatase non-receptor type 22 Homo sapiens 117-123 30389631-2 2019 5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4). Leukotriene C4 119-133 arachidonate 5-lipoxygenase activating protein Homo sapiens 64-68 30389631-2 2019 5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4). Leukotriene C4 135-139 arachidonate 5-lipoxygenase Homo sapiens 0-5 30389631-2 2019 5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4). Leukotriene C4 135-139 arachidonate 5-lipoxygenase activating protein Homo sapiens 64-68 30479216-5 2019 OBJECTIVE: In the present study, detailed computational analysis has been performed for PPAT protein, the key enzyme in de novo purine biosynthesis which is inhibited by many folate derivatives, hence we aimed to investigate and gauge the inhibitory effect of antifolate derivatives; lomexterol (LTX) methotrexate (LTX), and pipretixin (PTX) with human PPAT to effectively capture and inhibit De novo purine biosynthesis pathway. Leukotriene C4 296-299 phosphoribosyl pyrophosphate amidotransferase Homo sapiens 88-92 30479216-5 2019 OBJECTIVE: In the present study, detailed computational analysis has been performed for PPAT protein, the key enzyme in de novo purine biosynthesis which is inhibited by many folate derivatives, hence we aimed to investigate and gauge the inhibitory effect of antifolate derivatives; lomexterol (LTX) methotrexate (LTX), and pipretixin (PTX) with human PPAT to effectively capture and inhibit De novo purine biosynthesis pathway. Leukotriene C4 315-318 phosphoribosyl pyrophosphate amidotransferase Homo sapiens 88-92 30472514-7 2019 In addition, it is still unclear whether the NH2-terminal peptide of ARF1 suppresses FcepsilonRI-induced production of cytokines and lipid mediators such as leukotriene C4 (LTC4) from mast cells. Leukotriene C4 157-171 ADP ribosylation factor 1 Homo sapiens 69-73 30232176-5 2018 Vesicular transport studies confirmed a strong inhibitory effect of calcitriol and calcipotriol on MRP1-mediated uptake of tritium-labeled estradiol glucuronide and leukotriene C4 In cytotoxicity assays, MRP1-overexpressing cells exhibited hypersensitivity toward calcitriol and calcipotriol. Leukotriene C4 165-179 ATP binding cassette subfamily C member 1 Homo sapiens 99-103 30300856-9 2018 Following KPE, 33 BA patients showed RLC that required early LTX, while 24 had favorable course of disease with long-term survival with native liver (SNL). Leukotriene C4 61-64 integrin subunit alpha 9 Homo sapiens 37-40 29059080-4 2018 Although leukotrienes may be released by various infiltrating leukocytes, a recent study demonstrated that cytotoxic agents trigger production of leukotriene C4 (LTC4) in mouse kidney cells by activating a biosynthetic pathway based on microsomal glutathione-S-transferase 2 (MGST2). Leukotriene C4 146-160 microsomal glutathione S-transferase 2 Mus musculus 236-274 29054441-11 2018 CONCLUSION: Post-transplant serum AFP may have diagnostic value to detect HCC recurrence after LTx. Leukotriene C4 95-98 alpha fetoprotein Homo sapiens 34-37 29518474-5 2018 Leukotriene C4 production in RBL-2H3 cells stimulated by A23187 was also inhibited by both through the inhibition of ERK1/2 phosphorylation. Leukotriene C4 0-14 mitogen activated protein kinase 3 Rattus norvegicus 117-123 29632031-7 2018 In conclusion, baseline Edmondson stage, T stage, accumulated tumor diameter, microvascular cancer embolus, and AFP levels may be predictive of HCC recurrence following LTx; however, CTC levels and subtypes were not. Leukotriene C4 169-172 alpha fetoprotein Homo sapiens 112-115 29059080-4 2018 Although leukotrienes may be released by various infiltrating leukocytes, a recent study demonstrated that cytotoxic agents trigger production of leukotriene C4 (LTC4) in mouse kidney cells by activating a biosynthetic pathway based on microsomal glutathione-S-transferase 2 (MGST2). Leukotriene C4 146-160 microsomal glutathione S-transferase 2 Mus musculus 276-281 29277835-4 2017 RESULTS Omentin serum concentration decreased significantly within three days after LTx (350.5+-302.0 to 200.0+-0.90 ng/mL; p<0.05), while visfatin serum levels decreased later, 30 days after Ltx (4.81+-3.78 to 0.78+-0.35 [0.4-1.1] pg/mL; p<0.05). Leukotriene C4 84-87 intelectin 1 Homo sapiens 8-15 29277835-8 2017 CONCLUSIONS The study showed for the first time serum omentin and visfatin levels to be decreased after LTx in ESLD patients. Leukotriene C4 104-107 intelectin 1 Homo sapiens 54-61 29277835-8 2017 CONCLUSIONS The study showed for the first time serum omentin and visfatin levels to be decreased after LTx in ESLD patients. Leukotriene C4 104-107 nicotinamide phosphoribosyltransferase Homo sapiens 66-74 29277835-9 2017 Successful LTx contributes to the improvement of impaired lung function parameters and attenuation of ongoing inflammatory process, resulting in altered visfatin and omentin serum levels. Leukotriene C4 11-14 nicotinamide phosphoribosyltransferase Homo sapiens 153-161 29277835-9 2017 Successful LTx contributes to the improvement of impaired lung function parameters and attenuation of ongoing inflammatory process, resulting in altered visfatin and omentin serum levels. Leukotriene C4 11-14 intelectin 1 Homo sapiens 166-173 28637652-6 2017 A striking shift toward proinflammatory eicosanoids was observed when the same cells were exposed (30 min) to bacterial stimuli: M-CSF Mphis produced considerably more 5-lipoxygenase products, particularly leukotriene C4, potentially linked to M2 functions in asthma. Leukotriene C4 206-220 colony stimulating factor 1 Homo sapiens 129-134 29042765-2 2017 We aimed to evaluate the incidence and prognosis of cancer following LTx for COPD. Leukotriene C4 69-72 COPD Homo sapiens 77-81 29042765-10 2017 CONCLUSION: The cancer risk is markedly increased after LTx for COPD. Leukotriene C4 56-59 COPD Homo sapiens 64-68 28476472-5 2017 Multivariable analysis found the hazard of death to increase with a 10 mmHg increase in mean pulmonary artery pressure (mPAP) among recipients of bilateral LTx (HR = 1.12; 95% CI = 1.01, 1.24; p = 0.032), but not among recipients of single LTx (HR = 0.92; 95% CI = 0.80, 1.06; p = 0.234). Leukotriene C4 156-159 phospholipid phosphatase 1 Mus musculus 120-124 28447503-5 2017 In vitro system, we found that OODBL reduced leukotriene C4 production and degranulation through the suppression of cytosolic phospholipase A2 phosphorylation and phospholipase Cgamma-mediated Ca2+ influx in IgE/antigen-stimulated BMMCs. Leukotriene C4 45-59 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 116-142 28667163-0 2017 Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation. Leukotriene C4 0-14 interleukin 33 Mus musculus 27-32 28667163-4 2017 In this article, we show that airway challenges with the parent CysLT, leukotriene C4 (LTC4), given in combination with low-dose IL-33 to naive wild-type mice, led to synergistic increases in airway Th2 cytokines, eosinophilia, and peribronchial inflammation compared with IL-33 alone. Leukotriene C4 71-85 interleukin 33 Mus musculus 273-278 28476472-5 2017 Multivariable analysis found the hazard of death to increase with a 10 mmHg increase in mean pulmonary artery pressure (mPAP) among recipients of bilateral LTx (HR = 1.12; 95% CI = 1.01, 1.24; p = 0.032), but not among recipients of single LTx (HR = 0.92; 95% CI = 0.80, 1.06; p = 0.234). Leukotriene C4 240-243 phospholipid phosphatase 1 Mus musculus 120-124 27874209-9 2017 Leukotriene C4 synthase-deficient eosinophils exhibited impaired chemotaxis to CCL19 that was restored by exogenous leukotriene C4 . Leukotriene C4 116-130 leukotriene C4 synthase Mus musculus 0-23 27874209-9 2017 Leukotriene C4 synthase-deficient eosinophils exhibited impaired chemotaxis to CCL19 that was restored by exogenous leukotriene C4 . Leukotriene C4 116-130 chemokine (C-C motif) ligand 19 Mus musculus 79-84 27874209-11 2017 Exogenous administration of leukotriene C4 restored trafficking of eosinophils to paratracheal lymph nodes in leukotriene C4 synthase-deficient mice. Leukotriene C4 28-42 leukotriene C4 synthase Mus musculus 110-133 28402256-0 2017 A potential anti-tumor effect of leukotriene C4 through the induction of 15-hydroxyprostaglandin dehydrogenase expression in colon cancer cells. Leukotriene C4 33-47 carbonyl reductase 1 Homo sapiens 73-110 27842947-9 2017 CONCLUSIONS: Severity of RV dysfunction, TR, RV dilatation, increasing oxygen requirement, and increasing mPAP showed significant associations with the need for extracorporeal support during LTX in patients with PH. Leukotriene C4 191-194 phospholipid phosphatase 1 Mus musculus 106-110 27003330-1 2016 BACKGROUND: The calcineurin inhibitor (CNI) tacrolimus (Tac) is an effective immunosuppressant used after liver transplantation (LTx), but is often associated with CNI nephrotoxicity. Leukotriene C4 129-132 calcineurin binding protein 1 Homo sapiens 16-37 28405602-1 2017 BACKGROUND: Neurological disorders due to calcineurin inhibitor (CNI) treatment pose a well-known problem after liver transplantation (LTx). Leukotriene C4 135-138 calcineurin binding protein 1 Homo sapiens 42-63 28455997-2 2017 The aim of the study was to evaluate the prevalence of cardiac troponin I (cTnI) elevation in the perioperative period of LTx, and its potential relationship with 1-year mortality. Leukotriene C4 122-125 troponin I3, cardiac type Homo sapiens 55-73 28455997-2 2017 The aim of the study was to evaluate the prevalence of cardiac troponin I (cTnI) elevation in the perioperative period of LTx, and its potential relationship with 1-year mortality. Leukotriene C4 122-125 troponin I3, cardiac type Homo sapiens 75-79 28455997-9 2017 The most important predictor of cTnI increase was the duration of the LTx procedure followed by amount of packed red blood cells transfused, basic stroke volume index, and cardiac output index. Leukotriene C4 70-73 troponin I3, cardiac type Homo sapiens 32-36 28455997-10 2017 IN CONCLUSION: value of cTnI level assessed 24 hours post-surgery was a reliable predictor of death following LTx with optimal cut-off value of 0.215 ng/mL. Leukotriene C4 110-113 troponin I3, cardiac type Homo sapiens 24-28 27863043-1 2016 The GPR17 receptor is a G protein-coupled receptor (GPCR) that seems to respond to two unrelated families of endogenous ligands: nucleotide sugars (UDP, UDP-galactose, and UDP-glucose) and cysteinyl leukotrienes (LTD4 , LTC4 , and LTE4 ), with significant affinity at micromolar and nanomolar concentrations, respectively. Leukotriene C4 220-224 G protein-coupled receptor 17 Homo sapiens 4-9 26808090-12 2016 SIGNIFICANCE: Anaphylactic mediators exert non-uniform actions on the pulmonary and systemic circulation and airway in anesthetized BALB/c mice: PAF, LTC4 and serotonin cause substantial pulmonary vasoconstriction, while histamine biphasic responses of the initial nitric oxide dependent vasodilation followed by vasoconstriction; PAF, serotonin, and histamine, but not LTC4 or PGD2, evoke systemic vasodilatation; only serotonin induces airway constriction. Leukotriene C4 150-154 prostaglandin D2 synthase (brain) Mus musculus 378-382 26663361-6 2016 Furthermore, LTx rejection is associated with enhanced B cell presentation of donor antigen relative to HLA-nonidentical antigen in a novel cell-based assay and with a downregulated HLA-DOA gene in a subset of these children. Leukotriene C4 13-16 major histocompatibility complex, class II, DO alpha Homo sapiens 182-189 25961490-7 2015 Early after LTX, serum HLA-G levels were higher in patients with acute rejection episodes than nonrejectors. Leukotriene C4 12-15 major histocompatibility complex, class I, G Homo sapiens 23-28 27115997-3 2016 The CysLT1R is a high-affinity leukotriene D4 receptor with lower affinity for leukotriene C4 that is sensitive to the CysLT1R antagonist currently used to treat asthma and allergic rhinitis. Leukotriene C4 79-93 cysteinyl leukotriene receptor 1 Homo sapiens 4-11 27115997-3 2016 The CysLT1R is a high-affinity leukotriene D4 receptor with lower affinity for leukotriene C4 that is sensitive to the CysLT1R antagonist currently used to treat asthma and allergic rhinitis. Leukotriene C4 79-93 cysteinyl leukotriene receptor 1 Homo sapiens 119-126 26656251-2 2015 Here we show that ER stress and chemotherapy induce leukotriene C4 (LTC4) biosynthesis by transcriptionally upregulating and activating the enzyme microsomal glutathione-S-transferase 2 (MGST2) in cells of non-haematopoietic lineage. Leukotriene C4 52-66 microsomal glutathione S-transferase 2 Mus musculus 147-185 26656251-2 2015 Here we show that ER stress and chemotherapy induce leukotriene C4 (LTC4) biosynthesis by transcriptionally upregulating and activating the enzyme microsomal glutathione-S-transferase 2 (MGST2) in cells of non-haematopoietic lineage. Leukotriene C4 52-66 microsomal glutathione S-transferase 2 Mus musculus 187-192 25704617-0 2015 Leukotriene C4 induces bronchoconstriction and airway vascular hyperpermeability via the cysteinyl leukotriene receptor 2 in S-hexyl glutathione-treated guinea pigs. Leukotriene C4 0-14 cysteinyl leukotriene receptor 2 Cavia porcellus 89-121 25989360-5 2015 HLA-G SNPs were genotyped in 124 recipients who underwent LTx from 1996 to 2010 in Marseille, 123 healthy individuals and 26 cystic fibrosis patients not requiring LTx. Leukotriene C4 58-61 major histocompatibility complex, class I, G Homo sapiens 0-5 26160956-8 2015 The signaling pathway coupling VEGF to the effect on Orai3 involved activation of phospholipase Cgamma1, Ca(2+) release, cytosolic group IV phospholipase A2alpha, arachidonic acid production, and, in part, microsomal glutathione S-transferase 2, an enzyme which catalyses the formation of leukotriene C4 from arachidonic acid. Leukotriene C4 289-303 vascular endothelial growth factor A Homo sapiens 31-35 26160956-8 2015 The signaling pathway coupling VEGF to the effect on Orai3 involved activation of phospholipase Cgamma1, Ca(2+) release, cytosolic group IV phospholipase A2alpha, arachidonic acid production, and, in part, microsomal glutathione S-transferase 2, an enzyme which catalyses the formation of leukotriene C4 from arachidonic acid. Leukotriene C4 289-303 ORAI calcium release-activated calcium modulator 3 Homo sapiens 53-58 26170387-5 2015 The strongest upregulation of CD244 on circulating CD8(+) T cells was observed in patients who experienced CMV infection after LTx. Leukotriene C4 127-130 CD244 molecule Homo sapiens 30-35 26170387-5 2015 The strongest upregulation of CD244 on circulating CD8(+) T cells was observed in patients who experienced CMV infection after LTx. Leukotriene C4 127-130 CD8a molecule Homo sapiens 51-54 26170387-10 2015 These results suggest that CMV infection restrains CD8(+) T cell alloresponses after LTx. Leukotriene C4 85-88 CD8a molecule Homo sapiens 51-54 26221052-4 2015 Orai1 is also a pore-forming subunit of an arachidonic acid (or leukotriene C4)-regulated current Iarc that involves interactions among Orai1, Orai3, and STIM1. Leukotriene C4 64-78 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 26221052-4 2015 Orai1 is also a pore-forming subunit of an arachidonic acid (or leukotriene C4)-regulated current Iarc that involves interactions among Orai1, Orai3, and STIM1. Leukotriene C4 64-78 ORAI calcium release-activated calcium modulator 1 Homo sapiens 136-141 26221052-4 2015 Orai1 is also a pore-forming subunit of an arachidonic acid (or leukotriene C4)-regulated current Iarc that involves interactions among Orai1, Orai3, and STIM1. Leukotriene C4 64-78 ORAI calcium release-activated calcium modulator 3 Homo sapiens 143-148 26221052-4 2015 Orai1 is also a pore-forming subunit of an arachidonic acid (or leukotriene C4)-regulated current Iarc that involves interactions among Orai1, Orai3, and STIM1. Leukotriene C4 64-78 stromal interaction molecule 1 Homo sapiens 154-159 25935436-5 2015 RESULTS: The AA genotype of the rs882643 genetic variant of IL-17R was associated with higher PGD grades at 0 hour (adjusted p = 0.042), 12 hours (adjusted p = 0.013) and 48 hours (adjusted p = 0.0092) after LTx. Leukotriene C4 208-211 interleukin 17 receptor A Homo sapiens 60-66 25935436-6 2015 The GG genotype of the rs2241049 genetic variant of IL-17R was associated with higher PGD grades at 48 hours (adjusted p = 0.0067) after LTx. Leukotriene C4 137-140 interleukin 17 receptor A Homo sapiens 52-58 25457347-4 2015 Two cases of SPK after LTx were performed in our centre and we present our experience here. Leukotriene C4 23-26 symplekin scaffold protein Homo sapiens 13-16 25457347-17 2015 CONCLUSIONS: SPK could serve as an effective option for patients with diabetes and uremia after LTx. Leukotriene C4 96-99 symplekin scaffold protein Homo sapiens 13-16 26308415-14 2015 CONCLUSIONS: Long-term survival after Ltx, especially for early-onset TTR Val30Met patients, is excellent. Leukotriene C4 38-41 transthyretin Homo sapiens 70-73 26308415-15 2015 The risk of delaying Ltx by testing alternative treatments, especially in early-onset TTR Val30Met patients, requires consideration. Leukotriene C4 21-24 transthyretin Homo sapiens 86-89 26288187-7 2015 All LTx were due to primary sclerosing cholangitis (PSC) or PSC overlap syndromes. Leukotriene C4 4-7 PSC Homo sapiens 52-55 26288187-7 2015 All LTx were due to primary sclerosing cholangitis (PSC) or PSC overlap syndromes. Leukotriene C4 4-7 PSC Homo sapiens 60-63 24888532-2 2014 Primary sclerosing cholangitis (PSC) is known for its otherwise excellent outcome after LTX. Leukotriene C4 88-91 PSC Homo sapiens 32-35 25569771-12 2015 The mechanism involved epithelial protease-activated receptor-2-dependent production of leukotrienes C4 associated with an overexpression of leukotrienes receptor CysLTR1 by asthmatic BSM cells in vitro and ex vivo. Leukotriene C4 88-103 F2R like trypsin receptor 1 Homo sapiens 34-63 25569771-12 2015 The mechanism involved epithelial protease-activated receptor-2-dependent production of leukotrienes C4 associated with an overexpression of leukotrienes receptor CysLTR1 by asthmatic BSM cells in vitro and ex vivo. Leukotriene C4 88-103 cysteinyl leukotriene receptor 1 Homo sapiens 163-170 25347235-4 2015 The primary outcome was occurrence of a rapid SNa shift, defined as >=10 mmol/L in the first 24 h following LTx. Leukotriene C4 111-114 snail family transcriptional repressor 1 Homo sapiens 46-49 25347235-10 2015 CONCLUSION: Pre-operative hyponatremia and rapid peri-operative SNa shifts are associated with a more complicated post-operative course and worse outcomes following LTx. Leukotriene C4 165-168 snail family transcriptional repressor 1 Homo sapiens 64-67 25096855-5 2015 We observed overall higher anti-ETAR and anti-AT1R autoantibody titers in sera taken prior to LTx in the CF patient group as compared to COPD. Leukotriene C4 94-97 angiotensin II receptor type 1 Homo sapiens 46-50 24888532-4 2014 METHODS: This is a retrospective observational study including 126 consecutive patients treated with LTX for PSC between January 1, 1999 and August 31, 2012. Leukotriene C4 101-104 PSC Homo sapiens 109-112 25262831-5 2014 Nowadays, PBC is the third indication for LTx, after viral-related and alcoholic liver cirrhosis. Leukotriene C4 42-45 dihydrolipoamide S-acetyltransferase Homo sapiens 10-13 25262831-6 2014 Unfortunately, PBC recurs in 21-37% of patients at 10 years after LTx, and in 43% at 15 years after LTx, with the median time to recurrence of 3-5.5 years. Leukotriene C4 66-69 dihydrolipoamide S-acetyltransferase Homo sapiens 15-18 25262831-6 2014 Unfortunately, PBC recurs in 21-37% of patients at 10 years after LTx, and in 43% at 15 years after LTx, with the median time to recurrence of 3-5.5 years. Leukotriene C4 100-103 dihydrolipoamide S-acetyltransferase Homo sapiens 15-18 25034252-8 2014 In addition, FLAP knockdown reduced conversion of leukotriene A4 to leukotriene C4 (LTC4), suggesting a role for the activity of LTC4 synthase. Leukotriene C4 68-82 arachidonate 5-lipoxygenase activating protein Homo sapiens 13-17 25202281-3 2014 We investigated the relationship between ScO2 and end-tidal CO2 tension (EtCO2) during the various phases of LTx. Leukotriene C4 109-112 synthesis of cytochrome C oxidase 2 Homo sapiens 41-45 24925646-5 2014 Leukotriene C4 (LTC4) and LTD4 were used as the agonists to induce IL-8 production and the related changes in signal molecules. Leukotriene C4 0-14 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 24577728-6 2014 AS252424 dramatically attenuated c-Kit ligand (KL)-induced leukotriene C4 (LTC4) generation and degranulation in BMMCs. Leukotriene C4 59-73 kit ligand Mus musculus 33-45 24577728-6 2014 AS252424 dramatically attenuated c-Kit ligand (KL)-induced leukotriene C4 (LTC4) generation and degranulation in BMMCs. Leukotriene C4 59-73 kit ligand Mus musculus 47-49 25132968-2 2014 The most common indications for LTx in adults remain to be chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, cystic fibrosis, alpha-1 antitrypsin deficiency, and idiopathic pulmonary arterial hypertension. Leukotriene C4 32-35 serpin family A member 1 Homo sapiens 146-165 24380698-5 2014 Our results show that BOS+ LTx recipients had higher alpha-defensins (HNP1-3) and beta-defensin2 HBD2 concentration in BAL and serum compared to BOS-DSA-recipients and normal controls (p=0.03). Leukotriene C4 27-30 HNP1 Homo sapiens 70-76 24573112-2 2014 We hypothesized that application of C1-esterase-inhibitor (C1-INH) in LTX-recipients showing early signs of severe PGD would attenuate the condition. Leukotriene C4 70-73 serpin family G member 1 Homo sapiens 36-57 24573112-2 2014 We hypothesized that application of C1-esterase-inhibitor (C1-INH) in LTX-recipients showing early signs of severe PGD would attenuate the condition. Leukotriene C4 70-73 serpin family G member 1 Homo sapiens 59-65 24573112-2 2014 We hypothesized that application of C1-esterase-inhibitor (C1-INH) in LTX-recipients showing early signs of severe PGD would attenuate the condition. Leukotriene C4 70-73 phosphoglycerate dehydrogenase Homo sapiens 115-118 24725939-0 2014 Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4+ T cells across an in vitro blood-brain barrier model. Leukotriene C4 32-46 C-X3-C motif chemokine ligand 1 Homo sapiens 58-64 24725939-0 2014 Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4+ T cells across an in vitro blood-brain barrier model. Leukotriene C4 32-46 C-X3-C motif chemokine ligand 1 Homo sapiens 65-76 24725939-0 2014 Exposure of human astrocytes to leukotriene C4 promotes a CX3CL1/fractalkine-mediated transmigration of HIV-1-infected CD4+ T cells across an in vitro blood-brain barrier model. Leukotriene C4 32-46 CD4 molecule Homo sapiens 119-122 24725939-3 2014 We demonstrate that conditioned medium from human astrocytes treated with leukotriene C4 (LTC4) increases the transmigration of HIV-1-infected CD4(+) T cells across an in vitro blood-brain barrier (BBB) model using cultured brain endothelial cells. Leukotriene C4 74-88 CD4 molecule Homo sapiens 143-146 24366866-1 2014 Leukotriene (LT) C4 synthase (LTC4S) catalyzes the conjugation of the fatty acid LTA4 with the tripeptide GSH to produce LTC4, the parent compound of the cysteinyl leukotrienes, important mediators of asthma. Leukotriene C4 30-34 leukotriene C4 synthase Homo sapiens 0-28 24380698-5 2014 Our results show that BOS+ LTx recipients had higher alpha-defensins (HNP1-3) and beta-defensin2 HBD2 concentration in BAL and serum compared to BOS-DSA-recipients and normal controls (p=0.03). Leukotriene C4 27-30 defensin beta 4A Homo sapiens 82-96 24380698-5 2014 Our results show that BOS+ LTx recipients had higher alpha-defensins (HNP1-3) and beta-defensin2 HBD2 concentration in BAL and serum compared to BOS-DSA-recipients and normal controls (p=0.03). Leukotriene C4 27-30 defensin beta 4A Homo sapiens 97-101 23349245-7 2013 Rather, the signal for Orai1/3 channel activation is cytosolic leukotrieneC4 produced downstream thrombin receptor stimulation through the catalytic activity of leukotrieneC4 synthase. Leukotriene C4 63-76 ORAI calcium release-activated calcium modulator 1 Homo sapiens 23-30 23998930-0 2013 Oxidative stress potentially enhances FcepsilonRI-mediated leukotriene C4 release dependent on the late-phase increase of intracellular glutathione in mast cells. Leukotriene C4 59-73 Fc epsilon receptor Ia Homo sapiens 38-49 23515871-2 2013 Furthermore, STIM1 and Orai1, along with Orai3, encode store-independent Ca(2+) currents regulated by either arachidonate or its metabolite, leukotriene C4. Leukotriene C4 141-155 stromal interaction molecule 1 Homo sapiens 13-18 23515871-2 2013 Furthermore, STIM1 and Orai1, along with Orai3, encode store-independent Ca(2+) currents regulated by either arachidonate or its metabolite, leukotriene C4. Leukotriene C4 141-155 ORAI calcium release-activated calcium modulator 1 Homo sapiens 23-28 23515871-2 2013 Furthermore, STIM1 and Orai1, along with Orai3, encode store-independent Ca(2+) currents regulated by either arachidonate or its metabolite, leukotriene C4. Leukotriene C4 141-155 ORAI calcium release-activated calcium modulator 3 Homo sapiens 41-46 24314172-11 2013 Elevation of AST and gamma-GT would also appear to be early indicators of risk for LTx during follow-up of JF patients after successful PE. Leukotriene C4 83-86 solute carrier family 17 member 5 Homo sapiens 13-16 23695829-7 2013 Under native conditions, Orai3 was demonstrated to be an important component of store-independent arachidonate-regulated Ca(2+) (ARC) entry in HEK293 cells, and more recently of a store-independent leukotrieneC4-regulated Ca(2+) (LRC) entry pathway in vascular smooth muscle cells. Leukotriene C4 198-211 ORAI calcium release-activated calcium modulator 3 Homo sapiens 25-30 23878392-3 2013 These store-independent Orai3/Orai1 channels are gated by cytosolic leukotriene C4 (LTC4) and require STIM1 downstream LTC4 action. Leukotriene C4 68-82 ORAI calcium release-activated calcium modulator 3 Homo sapiens 24-29 23878392-3 2013 These store-independent Orai3/Orai1 channels are gated by cytosolic leukotriene C4 (LTC4) and require STIM1 downstream LTC4 action. Leukotriene C4 68-82 ORAI calcium release-activated calcium modulator 1 Homo sapiens 30-35 22982805-3 2012 We investigated the effects of SD on cyclooxygenase-2 (COX-2)-dependent prostaglandin D(2) (PGD(2)) and 5-lipoxygenase (5-LO)-dependent leukotriene C(4) (LTC(4)) generations as well as degranulation in cytokine-stimulated mouse bone marrow-derived mast cells (BMMCs). Leukotriene C4 136-149 prostaglandin-endoperoxide synthase 2 Mus musculus 37-53 23711850-5 2013 FMLP-induced leukotriene C4 production by basophils was also enhanced by CRA-1 mAb pretreatment. Leukotriene C4 13-27 formyl peptide receptor 1 Homo sapiens 0-4 22982805-3 2012 We investigated the effects of SD on cyclooxygenase-2 (COX-2)-dependent prostaglandin D(2) (PGD(2)) and 5-lipoxygenase (5-LO)-dependent leukotriene C(4) (LTC(4)) generations as well as degranulation in cytokine-stimulated mouse bone marrow-derived mast cells (BMMCs). Leukotriene C4 136-149 prostaglandin-endoperoxide synthase 2 Mus musculus 55-60 22982805-3 2012 We investigated the effects of SD on cyclooxygenase-2 (COX-2)-dependent prostaglandin D(2) (PGD(2)) and 5-lipoxygenase (5-LO)-dependent leukotriene C(4) (LTC(4)) generations as well as degranulation in cytokine-stimulated mouse bone marrow-derived mast cells (BMMCs). Leukotriene C4 136-149 arachidonate 5-lipoxygenase Mus musculus 104-118 22921920-0 2012 Ischemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats. Leukotriene C4 35-49 leukotriene C4 synthase Rattus norvegicus 74-97 24009845-2 2012 In this study, we examined the effects of SF on the generation of 5-lipoxygenase (5-LO) dependent leukotriene C4 (LTC4), cyclooxygenase-2 (COX-2) dependent prostaglandin D2 (PGD2), and on phospholipase Cgamma1 (PLCgamma1)-mediated degranulation in SCF-induced mouse bone marrow-derived mast cells (BMMCs). Leukotriene C4 98-112 arachidonate 5-lipoxygenase Mus musculus 66-80 22450322-4 2012 Primary isolated valvular interstitial cells (VICs) were used to explore the effects of cytokines and leukotriene C(4) (LTC(4)) on valvular PARP-1 expression. Leukotriene C4 102-115 poly(ADP-ribose) polymerase 1 Homo sapiens 140-146 22430736-2 2012 In the current study, we found that cell-surface FcepsilonRI expression is a critical factor participant in PpL-mediated full activation of murine mast cells, which includes cytokine production, the degranulation response, and leukotriene C(4) (LTC(4)) release, and that engagement of the FcepsilonRI with IgEkappa and PpL is enough to induce tyrosine phosphorylation of ITAM in the FcRbeta- and gamma-signaling subunits. Leukotriene C4 227-240 Fc epsilon receptor Ia Homo sapiens 49-60 22430736-2 2012 In the current study, we found that cell-surface FcepsilonRI expression is a critical factor participant in PpL-mediated full activation of murine mast cells, which includes cytokine production, the degranulation response, and leukotriene C(4) (LTC(4)) release, and that engagement of the FcepsilonRI with IgEkappa and PpL is enough to induce tyrosine phosphorylation of ITAM in the FcRbeta- and gamma-signaling subunits. Leukotriene C4 227-240 periplakin Homo sapiens 108-111 22695718-4 2012 MRP1-dependent transport of leukotriene C(4) and estradiol-17beta-d-glucuronide into vesicles derived from MRP1 CK2alpha(-) cells was decreased compared with MRP1 vesicles. Leukotriene C4 28-41 mitochondrial 37S ribosomal protein MRP1 Saccharomyces cerevisiae S288C 0-4 22695718-4 2012 MRP1-dependent transport of leukotriene C(4) and estradiol-17beta-d-glucuronide into vesicles derived from MRP1 CK2alpha(-) cells was decreased compared with MRP1 vesicles. Leukotriene C4 28-41 mitochondrial 37S ribosomal protein MRP1 Saccharomyces cerevisiae S288C 107-111 22695718-4 2012 MRP1-dependent transport of leukotriene C(4) and estradiol-17beta-d-glucuronide into vesicles derived from MRP1 CK2alpha(-) cells was decreased compared with MRP1 vesicles. Leukotriene C4 28-41 casein kinase 2 alpha 2 Homo sapiens 112-120 22695718-4 2012 MRP1-dependent transport of leukotriene C(4) and estradiol-17beta-d-glucuronide into vesicles derived from MRP1 CK2alpha(-) cells was decreased compared with MRP1 vesicles. Leukotriene C4 28-41 mitochondrial 37S ribosomal protein MRP1 Saccharomyces cerevisiae S288C 107-111 22217203-1 2012 Human leukotriene C4 synthase (hLTC4S) is an integral membrane protein that catalyzes the committed step in the biosynthesis of cysteinyl-leukotrienes, i.e., formation of leukotriene C4 (LTC4). Leukotriene C4 6-20 leukotriene C4 synthase Homo sapiens 31-37 21896013-7 2011 Ours results suggest that leukotriene C(4) interferes with the complete maturation of inflammatory DCs in terms of phenotype and antigen uptake, while favouring the release of IL-23, the main cytokine involved in the maintenance of the Th17 profile. Leukotriene C4 26-39 interleukin 23, alpha subunit p19 Mus musculus 176-181 22102725-7 2011 Prestimulation of human eosinophils with arachidonic acid (10 muM) or human eotaxin (6 nM) also enhanced HQL-79-sensitive PGD(2) synthesis, which, by acting on membrane-expressed specific receptors (D prostanoid receptors 1 and 2), displayed an autocrine/paracrine ability to trigger leukotriene C(4) synthesis and lipid body biogenesis, hallmark events of eosinophil activation. Leukotriene C4 284-297 latexin Homo sapiens 62-65 22102725-7 2011 Prestimulation of human eosinophils with arachidonic acid (10 muM) or human eotaxin (6 nM) also enhanced HQL-79-sensitive PGD(2) synthesis, which, by acting on membrane-expressed specific receptors (D prostanoid receptors 1 and 2), displayed an autocrine/paracrine ability to trigger leukotriene C(4) synthesis and lipid body biogenesis, hallmark events of eosinophil activation. Leukotriene C4 284-297 C-C motif chemokine ligand 11 Homo sapiens 76-83 22293352-4 2012 In addition, JW inhibited 5-lipoxygenase (5-LOX)-dependent generation of leukotriene C(4) (LTC(4)) as well as degranulation in a dose-dependent manner. Leukotriene C4 73-86 arachidonate 5-lipoxygenase Mus musculus 26-40 22293352-4 2012 In addition, JW inhibited 5-lipoxygenase (5-LOX)-dependent generation of leukotriene C(4) (LTC(4)) as well as degranulation in a dose-dependent manner. Leukotriene C4 73-86 arachidonate 5-lipoxygenase Mus musculus 42-47 21214543-4 2011 Catestatin and its naturally occurring variants caused the human mast cell line LAD2 and peripheral blood-derived mast cells to migrate, degranulate and release leukotriene C(4) and prostaglandins D(2) and E(2). Leukotriene C4 161-174 chromogranin A Homo sapiens 0-10 21975811-4 2011 In addition, this compound inhibited 5-lipoxygenase (5-LOX) dependent production of leukotriene C(4) in a dose-dependent manner, with an IC(50) of 0.032 muM. Leukotriene C4 84-97 arachidonate 5-lipoxygenase Mus musculus 37-51 21975811-4 2011 In addition, this compound inhibited 5-lipoxygenase (5-LOX) dependent production of leukotriene C(4) in a dose-dependent manner, with an IC(50) of 0.032 muM. Leukotriene C4 84-97 arachidonate 5-lipoxygenase Mus musculus 53-58 21843266-3 2011 METHODS: This study represents a retrospective review of biliary complications, patient and graft survival after LTx in PSC patients based on type of biliary reconstruction. Leukotriene C4 113-116 PSC Homo sapiens 120-123 21624839-8 2011 RESULTS: At 6 and 12 months after LTx, versican production was higher in fibroblasts from LTx patients (p < 0.01 p < 0.01) than from controls. Leukotriene C4 34-37 versican Homo sapiens 39-47 21624839-12 2011 CONCLUSIONS: LTx changes the phenotype of fibroblasts to a non-proliferative but extracellular matrix-producing cell due to wound healing involving TGF-beta(1). Leukotriene C4 13-16 transforming growth factor beta 1 Homo sapiens 148-159 20973774-0 2011 Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. Leukotriene C4 92-105 prostaglandin D2 receptor Homo sapiens 32-37 20973774-0 2011 Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils. Leukotriene C4 92-105 transcription factor Dp-2 Homo sapiens 42-47 21426314-2 2011 Activation of eosinophils by diverse stimuli, including prostaglandin D(2) (PD(2) ), leads to leukotriene C(4) (LTC(4) ) synthesis that contributes to the expulsion of parasites and to epithelial injury in allergic inflammation. Leukotriene C4 94-107 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 56-81 21307858-1 2011 Activation of the prostaglandin D2 receptor (PTGDR) may contribute to pulmonary vasodilation, bronchoconstriction, recruitment of eosinophils, basophils and T-lymphocytes, and enhanced synthesis of leukotriene C4. Leukotriene C4 198-212 prostaglandin D2 receptor Homo sapiens 18-43 21307858-1 2011 Activation of the prostaglandin D2 receptor (PTGDR) may contribute to pulmonary vasodilation, bronchoconstriction, recruitment of eosinophils, basophils and T-lymphocytes, and enhanced synthesis of leukotriene C4. Leukotriene C4 198-212 prostaglandin D2 receptor Homo sapiens 45-50 21447318-9 2011 Our data show that the K(m) values for leukotriene C(4) are equivalent for GGT1 and GGT5 at 10.8 and 10.2muM, respectively. Leukotriene C4 39-52 gamma-glutamyltransferase 1 Homo sapiens 75-79 21447318-9 2011 Our data show that the K(m) values for leukotriene C(4) are equivalent for GGT1 and GGT5 at 10.8 and 10.2muM, respectively. Leukotriene C4 39-52 gamma-glutamyltransferase 5 Homo sapiens 84-88 20539011-0 2011 Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C4-synthesizing lipid bodies. Leukotriene C4 110-124 macrophage migration inhibitory factor Homo sapiens 19-57 20539011-0 2011 Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C4-synthesizing lipid bodies. Leukotriene C4 110-124 C-C motif chemokine ligand 11 Homo sapiens 62-69 21106245-3 2011 The release of beta-hexosaminidase, leukotriene C(4), and IL-8, but not IL-6, was strongly enhanced in response to sequential challenge of mast cells with IL-4, SCF and FceRI cross-linking compared to stimulation by FceRI cross-linking alone. Leukotriene C4 36-49 interleukin 4 Homo sapiens 155-159 21106848-4 2011 Administration of a peptide antagonist that targets the Src family member Lyn before cytokine (IL-5/IL-3) priming of blood eosinophils inhibited the synergistic increase of fMLP-induced activation of Ras, ERK1/2 and Akt, as well as the release of the proinflammatory factor leukotriene C(4). Leukotriene C4 274-287 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 74-77 21106848-4 2011 Administration of a peptide antagonist that targets the Src family member Lyn before cytokine (IL-5/IL-3) priming of blood eosinophils inhibited the synergistic increase of fMLP-induced activation of Ras, ERK1/2 and Akt, as well as the release of the proinflammatory factor leukotriene C(4). Leukotriene C4 274-287 interleukin 5 Homo sapiens 95-99 21106848-4 2011 Administration of a peptide antagonist that targets the Src family member Lyn before cytokine (IL-5/IL-3) priming of blood eosinophils inhibited the synergistic increase of fMLP-induced activation of Ras, ERK1/2 and Akt, as well as the release of the proinflammatory factor leukotriene C(4). Leukotriene C4 274-287 formyl peptide receptor 1 Homo sapiens 173-177 21106848-7 2011 Altogether, our data demonstrate a central role for Lyn in the mechanisms of IL-5 family priming and suggest that Lyn contributes to the upregulation of the Ras-ERK1/2 and PI3K-Akt cascades, as well as the increased leukotriene C(4) release observed in response to fMLP in "primed" eosinophils. Leukotriene C4 216-229 interleukin 5 Homo sapiens 77-81 21106848-7 2011 Altogether, our data demonstrate a central role for Lyn in the mechanisms of IL-5 family priming and suggest that Lyn contributes to the upregulation of the Ras-ERK1/2 and PI3K-Akt cascades, as well as the increased leukotriene C(4) release observed in response to fMLP in "primed" eosinophils. Leukotriene C4 216-229 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 114-117 21106848-7 2011 Altogether, our data demonstrate a central role for Lyn in the mechanisms of IL-5 family priming and suggest that Lyn contributes to the upregulation of the Ras-ERK1/2 and PI3K-Akt cascades, as well as the increased leukotriene C(4) release observed in response to fMLP in "primed" eosinophils. Leukotriene C4 216-229 mitogen-activated protein kinase 3 Homo sapiens 161-167 21106848-7 2011 Altogether, our data demonstrate a central role for Lyn in the mechanisms of IL-5 family priming and suggest that Lyn contributes to the upregulation of the Ras-ERK1/2 and PI3K-Akt cascades, as well as the increased leukotriene C(4) release observed in response to fMLP in "primed" eosinophils. Leukotriene C4 216-229 AKT serine/threonine kinase 1 Homo sapiens 177-180 21106848-7 2011 Altogether, our data demonstrate a central role for Lyn in the mechanisms of IL-5 family priming and suggest that Lyn contributes to the upregulation of the Ras-ERK1/2 and PI3K-Akt cascades, as well as the increased leukotriene C(4) release observed in response to fMLP in "primed" eosinophils. Leukotriene C4 216-229 formyl peptide receptor 1 Homo sapiens 265-269 20826745-13 2011 CONCLUSIONS: The cystatin C equation is a non-invasive and sensitive diagnostic tool to detect renal dysfunction in children after Ltx at an early stage. Leukotriene C4 131-134 cystatin C Homo sapiens 17-27 21968553-1 2011 Several studies have shown that the multidrug resistant protein MRP2 mediates the transport of chemotherapeutic drugs and normal cell metabolites, including Leukotriene C (LTC(4)); however direct binding of the LTC(4) to MRP2 has not been demonstrated. Leukotriene C4 157-170 ATP binding cassette subfamily C member 2 Homo sapiens 64-68 21968553-1 2011 Several studies have shown that the multidrug resistant protein MRP2 mediates the transport of chemotherapeutic drugs and normal cell metabolites, including Leukotriene C (LTC(4)); however direct binding of the LTC(4) to MRP2 has not been demonstrated. Leukotriene C4 157-170 ATP binding cassette subfamily C member 2 Homo sapiens 221-225 21106245-3 2011 The release of beta-hexosaminidase, leukotriene C(4), and IL-8, but not IL-6, was strongly enhanced in response to sequential challenge of mast cells with IL-4, SCF and FceRI cross-linking compared to stimulation by FceRI cross-linking alone. Leukotriene C4 36-49 KIT ligand Homo sapiens 161-164 21106245-3 2011 The release of beta-hexosaminidase, leukotriene C(4), and IL-8, but not IL-6, was strongly enhanced in response to sequential challenge of mast cells with IL-4, SCF and FceRI cross-linking compared to stimulation by FceRI cross-linking alone. Leukotriene C4 36-49 membrane spanning 4-domains A2 Homo sapiens 169-174 20497485-7 2010 Pretreatment of LAD2 with SP followed by stimulation with Pam3CSK4 or LTA increased production of leukotriene C4 (LTC(4) ) and interleukin (IL)-8 compared with treatment with Pam3CSK4 or LTA alone (>2-fold; P<0 01). Leukotriene C4 98-112 tachykinin precursor 1 Homo sapiens 26-28 21206923-9 2010 One week after LTx, PF of circulating donor-specific CD4+ and CD8+ T cells increased significantly, while only a minor increase in numbers of T cells reacting to 3rd party allo-antigens was observed. Leukotriene C4 15-18 CD4 molecule Homo sapiens 53-56 20691611-10 2010 Chronic stimulation of epithelium by antibodies to MHC and resulting increased levels of defensins induce growth factor production and epithelial proliferation contributing to the development of chronic rejection after LTx. Leukotriene C4 219-222 major histocompatibility complex, class I, C Homo sapiens 51-54 20211214-5 2010 Abs to MICA alleles (*001 and *009) developed approximately 6 months after LTx and peak titers were present at the time of clinical diagnosis of BOS (16.3 +/- 2.7 months). Leukotriene C4 75-78 MHC class I polypeptide-related sequence A Homo sapiens 7-11 20583081-8 2010 After LTX, but not after renal transplantation, significant numbers of donor CD56dim NK and CD56(+) T cells were detected in the recipient circulation for approximately 2 weeks. Leukotriene C4 6-9 neural cell adhesion molecule 1 Homo sapiens 77-81 19566819-5 2010 Multidrug resistance-associated protein 1 can be distinguished from MRP2 and MRP3 by its higher affinity for leukotriene C(4). Leukotriene C4 109-122 ATP binding cassette subfamily C member 1 Homo sapiens 0-41 20190140-5 2010 hBDs and LL-37 also induced the release of other pruritogenic mediators, including IL-2, IL-4, IL-6, GM-CSF, nerve growth factor, PGE(2), and leukotriene C(4), and increased mRNA expression of substance P. hBD- and LL-37-mediated IL-31 production/release was markedly reduced by pertussis toxin and wortmannin, inhibitors of G-protein and PI3K, respectively. Leukotriene C4 142-155 cathelicidin antimicrobial peptide Homo sapiens 9-14 20190140-5 2010 hBDs and LL-37 also induced the release of other pruritogenic mediators, including IL-2, IL-4, IL-6, GM-CSF, nerve growth factor, PGE(2), and leukotriene C(4), and increased mRNA expression of substance P. hBD- and LL-37-mediated IL-31 production/release was markedly reduced by pertussis toxin and wortmannin, inhibitors of G-protein and PI3K, respectively. Leukotriene C4 142-155 HBD Homo sapiens 0-3 19566819-5 2010 Multidrug resistance-associated protein 1 can be distinguished from MRP2 and MRP3 by its higher affinity for leukotriene C(4). Leukotriene C4 109-122 ATP binding cassette subfamily C member 2 Homo sapiens 68-72 19566819-5 2010 Multidrug resistance-associated protein 1 can be distinguished from MRP2 and MRP3 by its higher affinity for leukotriene C(4). Leukotriene C4 109-122 ATP binding cassette subfamily C member 3 Homo sapiens 77-81 19956764-8 2009 We did observe that DST+LTx (but not DST alone) induced the time-dependent formation of CD4(+)Foxp3(+) Tregs that potently suppressed alloantigen-induced activation of naive LEW T-cells in vitro and liver allograft rejection in vivo. Leukotriene C4 24-27 CD4 molecule Homo sapiens 88-91 19866483-2 2010 Here we show prominent MDC chimerism in the recipient"s circulation early after clinical liver transplantation (LTx) but not after renal transplantation (RTx). Leukotriene C4 112-115 C-C motif chemokine ligand 22 Homo sapiens 23-26 19685171-2 2010 Substrates of MRP1 are, among others, glutathione and the leukotriene C(4) (LTC(4)), an eicosanoid and mediator of inflammation. Leukotriene C4 58-71 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 14-18 19835845-0 2009 Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells. Leukotriene C4 48-62 Janus kinase 2 Rattus norvegicus 8-22 19835845-3 2009 Our results show that the treatment of IgE-sensitized mouse mast cells with an inhibitor of JAK2 (AG490) blocked the release of leukotriene C(4) in a dose-dependent fashion after antigen challenge. Leukotriene C4 128-141 Janus kinase 2 Mus musculus 92-96 19956764-8 2009 We did observe that DST+LTx (but not DST alone) induced the time-dependent formation of CD4(+)Foxp3(+) Tregs that potently suppressed alloantigen-induced activation of naive LEW T-cells in vitro and liver allograft rejection in vivo. Leukotriene C4 24-27 forkhead box P3 Homo sapiens 94-99 19688741-4 2009 The release of histamine in the absence of Tec was normal in vitro and in vivo; however, leukotriene C(4) levels were reduced in Tec(-) (/) (-) BMMC. Leukotriene C4 89-102 tec protein tyrosine kinase Mus musculus 129-132 19328934-6 2009 A correlation between plasma CRP concentration and BAL interleukin levels was present at discharge (IL-6 and IL-8) and at 6 months (IL-8) after LTx. Leukotriene C4 144-147 C-reactive protein Homo sapiens 29-32 19632576-3 2009 We hypothesized that baseline plasma or bronchoalveolar lavage (BAL) CRP might be prognostic for the long-term outcome after LTx. Leukotriene C4 125-128 C-reactive protein Homo sapiens 69-72 19398503-8 2009 Finally, the differing abilities of the cysteinyl leukotriene derivatives leukotriene C(4), D(4), and F(4) to inhibit estradiol glucuronide transport by wild-type and K332L mutant MRP1 provide further evidence that TM6-Lys(332) is involved in the recognition of the gamma-Glu portion of substrates and modulators containing GSH or GSH-like moieties. Leukotriene C4 74-87 ATP binding cassette subfamily B member 1 Homo sapiens 180-184 19656137-7 2009 We conclude that HLA-G expression in the bronchial epithelium of lung allograft is elevated in some LTx recipients in association with their functional stability, suggesting a potential role of HLA-G as a tolerance marker. Leukotriene C4 100-103 major histocompatibility complex, class I, G Homo sapiens 17-22 19826192-7 2009 Leukotriene C(4) (10 nM) increased Ca(2+) entry, decreased forward scatter, activated caspases 3 and 8, and stimulated annexin V-binding. Leukotriene C4 0-13 caspase 3 Homo sapiens 86-102 19826192-7 2009 Leukotriene C(4) (10 nM) increased Ca(2+) entry, decreased forward scatter, activated caspases 3 and 8, and stimulated annexin V-binding. Leukotriene C4 0-13 annexin A5 Homo sapiens 119-128 19328934-7 2009 CONCLUSION: Systemic inflammation and IL-8-mediated neutrophilic airway inflammation seem to be associated after LTx. Leukotriene C4 113-116 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 18936079-3 2008 Spontaneous depolarizations were abolished by the P2X(1) receptor antagonist NF449 (10 microm) (frequency 8.5 +/- 8.5% of controls), insensitive to the muscarinic acetylcholine receptor antagonist atropine (1 microm) (103.4 +/- 3.0%), and became more frequent in latrotoxin (LTX; 1 nm) (438 +/- 95%), suggesting that they are spontaneous excitatory junction potentials (sEJPs). Leukotriene C4 275-278 purinergic receptor P2X, ligand-gated ion channel, 1 Mus musculus 50-65 18976293-9 2009 Collectively, allospecific CD154 + T cells provide an estimate of rejection risk in children with LTx. Leukotriene C4 98-101 CD40 ligand Homo sapiens 27-32 18468626-1 2009 BACKGROUND: Secretory phospholipase A(2) (sPLA(2)) degrades cell membrane phospholipids and plays an important role in the synthesis of pro-inflammatory lipid mediators (arachidonic acid and cytokines) during inflammatory events such as ischemia-reperfusion injury after liver transplantation (LTx). Leukotriene C4 294-297 phospholipase A2 group X Homo sapiens 12-40 18468626-1 2009 BACKGROUND: Secretory phospholipase A(2) (sPLA(2)) degrades cell membrane phospholipids and plays an important role in the synthesis of pro-inflammatory lipid mediators (arachidonic acid and cytokines) during inflammatory events such as ischemia-reperfusion injury after liver transplantation (LTx). Leukotriene C4 294-297 phospholipase A2 group X Homo sapiens 42-49 19063607-9 2008 Moreover, introduction of the P794A mutation into wild-type MRP1 increased transport of leukotriene C(4) approximately 2-fold. Leukotriene C4 88-101 ATP binding cassette subfamily C member 1 Homo sapiens 60-64 18775981-8 2008 We have constructed a series of MRP1/MRP3 hybrids and used them to identify a region of MRP1 that is critical for binding and transport of GSH conjugates such as leukotriene C(4) (LTC(4)). Leukotriene C4 162-175 ATP binding cassette subfamily C member 1 Homo sapiens 32-36 18775981-8 2008 We have constructed a series of MRP1/MRP3 hybrids and used them to identify a region of MRP1 that is critical for binding and transport of GSH conjugates such as leukotriene C(4) (LTC(4)). Leukotriene C4 162-175 ATP binding cassette subfamily C member 3 Homo sapiens 37-41 18775981-8 2008 We have constructed a series of MRP1/MRP3 hybrids and used them to identify a region of MRP1 that is critical for binding and transport of GSH conjugates such as leukotriene C(4) (LTC(4)). Leukotriene C4 162-175 ATP binding cassette subfamily C member 1 Homo sapiens 88-92 19059376-3 2009 We demonstrated DMRP as a functional orthologue of its human counterparts capable of transporting several human MRP substrates like beta-estradiol 17-beta-D-glucuronide, leukotriene C4, calcein, fluo3 and carboxydichlorofluorescein. Leukotriene C4 170-184 Multidrug-Resistance like Protein 1 Drosophila melanogaster 17-20 19571568-7 2009 Pam3CSK4 also suppressed leukotriene C(4) production triggered by engagement of the high-affinity IgE receptor, FcepsilonRI. Leukotriene C4 25-38 Fc receptor, IgE, high affinity I, gamma polypeptide Mus musculus 112-123 18776917-9 2008 Similarly, the production of leukotriene C4 after stimulation with calcium ionophore, and eosinophil chemotaxis in response to eotaxin, as well as CD11b upregulation and CD62 L shedding was also significantly reduced by trans-resveratrol, at concentrations above 5 microM. Leukotriene C4 29-43 C-C motif chemokine ligand 11 Homo sapiens 127-134 18776917-9 2008 Similarly, the production of leukotriene C4 after stimulation with calcium ionophore, and eosinophil chemotaxis in response to eotaxin, as well as CD11b upregulation and CD62 L shedding was also significantly reduced by trans-resveratrol, at concentrations above 5 microM. Leukotriene C4 29-43 integrin subunit alpha M Homo sapiens 147-152 18776917-9 2008 Similarly, the production of leukotriene C4 after stimulation with calcium ionophore, and eosinophil chemotaxis in response to eotaxin, as well as CD11b upregulation and CD62 L shedding was also significantly reduced by trans-resveratrol, at concentrations above 5 microM. Leukotriene C4 29-43 selectin L Homo sapiens 170-176 18083708-7 2008 Prostaglandin E2, prostaglandin I2, and leukotriene C4 are produced by cPLA2alpha+/+ but not cPLA2alpha-/- macrophages in response to WTLM and DeltahlyLM. Leukotriene C4 40-54 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 71-81 18656796-9 2008 This relationship between reflux and airway colonization and their role in the development of chronic allograft dysfunction/BOS after LTx should be further elucidated; nevertheless, induction of IL-8-mediated neutrophilic airway inflammation may be a putative mechanism. Leukotriene C4 134-137 C-X-C motif chemokine ligand 8 Homo sapiens 195-199 20525128-7 2008 Leukotriene C4 (LTC4) synthase is the enzyme responsible for the production of leukotriene C4, the chief cysteinyl leukotriene responsible for AEA. Leukotriene C4 79-93 leukotriene C4 synthase Homo sapiens 0-30 18506003-0 2008 Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. Leukotriene C4 104-118 ATP binding cassette subfamily C member 1 Rattus norvegicus 0-30 18506003-3 2008 We hypothesize that inside-outside transport of leukotriene C(4) (LTC(4)) via MRP1 is a substantial proatherogenic mechanism in the vasculature. Leukotriene C4 48-61 ATP binding cassette subfamily C member 1 Rattus norvegicus 78-82 18156181-1 2008 Ca2+ entry through store-operated Ca2+ channels drives the production of the pro-inflammatory molecule leukotriene C4 (LTC4) from mast cells through a pathway involving Ca2+-dependent protein kinase C, mitogen-activated protein kinases ERK1/2, phospholipase A2, and 5-lipoxygenase. Leukotriene C4 103-117 mitogen-activated protein kinase 3 Homo sapiens 236-242 18440824-1 2008 Leukotriene C(4) synthase (LTC4S) is a member of the MAPEG family of integral membrane proteins and catalyzes the conjugation of leukotriene A(4) with glutathione to form leukotriene C(4), a powerful mediator of allergic inflammation and anaphylaxis. Leukotriene C4 171-184 leukotriene C4 synthase Rattus norvegicus 0-25 18440824-1 2008 Leukotriene C(4) synthase (LTC4S) is a member of the MAPEG family of integral membrane proteins and catalyzes the conjugation of leukotriene A(4) with glutathione to form leukotriene C(4), a powerful mediator of allergic inflammation and anaphylaxis. Leukotriene C4 171-184 leukotriene C4 synthase Rattus norvegicus 27-32 17911611-3 2007 In this study, we find that stimulation of muscarinic receptors in cultured mast cells results in Ca(2+)-dependent activation of protein kinase Calpha and the mitogen activated protein kinases ERK1/2 and this is required for the subsequent stimulation of the enzymes Ca(2+)-dependent phospholipase A(2) and 5-lipoxygenase, generating the intracellular messenger arachidonic acid and the proinflammatory intercellular messenger leukotriene C(4). Leukotriene C4 427-440 mitogen activated protein kinase 3 Rattus norvegicus 193-199 17947453-0 2008 Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. Leukotriene C4 94-108 prostaglandin E receptor 2 Rattus norvegicus 46-49 17947453-0 2008 Gastric mucosal protection against ethanol by EP2 and EP4 signaling through the inhibition of leukotriene C4 production. Leukotriene C4 94-108 prostaglandin E receptor 4 Rattus norvegicus 54-57 18005261-5 2008 We found that physiological concentrations of HBV-sPLA2 induce rapid leukotriene C4 production from purified human basophils within 5 min, while interleukin (IL)-4 expression and production was induced at later time-points. Leukotriene C4 69-83 phospholipase A2 group X Homo sapiens 50-55 17646169-5 2007 Both enantiomers altered leukotriene C(4) and calcein transport by MRP1. Leukotriene C4 25-38 ATP binding cassette subfamily C member 1 Homo sapiens 67-71 17484769-9 2007 Jurkat cells produced leukotriene C(4) and a small amount of leukotriene B(4) in response to CD3-CD28 cross-linking. Leukotriene C4 22-35 CD28 molecule Homo sapiens 97-101 17692671-3 2007 In patients scheduled for LTx, induction of anesthesia could be a dangerous moment with the possibility of cardiogenic shock if pulmonary hypertension (PH) exists; pneumatic tamponade is also possible in patients with emphysema caused by alpha(1)-antitrypsin deficiency, with subsequent cardiac insufficiency. Leukotriene C4 26-29 serpin family A member 1 Homo sapiens 238-258 17645770-2 2007 We observed a threefold reduction of circulating CD1c(+) MDC immediately after LTX (n = 16; P < 0.01), and normalization between 3 and 12 months after LTX. Leukotriene C4 79-82 CD1c molecule Homo sapiens 49-53 17632546-3 2007 This intermediate is conjugated with glutathione (GSH) to produce leukotriene C4 (LTC4) in a reaction catalysed by LTC4 synthase: this reaction is the key step in cysteinyl leukotriene formation. Leukotriene C4 66-80 leukotriene C4 synthase Homo sapiens 115-128 17478601-1 2007 The exporter ABCC2 (cMOAT, MRP2) is a membrane-bound protein on the apical side of enterocytes and hepatic biliary vessels that transports leukotriene C(4), glutathione, some conjugated bile salts, drugs, xenobiotics, and phytonutrients. Leukotriene C4 139-152 ATP binding cassette subfamily C member 2 Homo sapiens 13-18 18516250-5 2007 Labeled leukotriene D(4) is prepared by treatment of labeled leukotriene C(4) with commercially available gamma-glutamyl transpeptidase. Leukotriene C4 61-74 inactive glutathione hydrolase 2 Homo sapiens 106-135 17645770-2 2007 We observed a threefold reduction of circulating CD1c(+) MDC immediately after LTX (n = 16; P < 0.01), and normalization between 3 and 12 months after LTX. Leukotriene C4 79-82 C-C motif chemokine ligand 22 Homo sapiens 57-60 17645770-6 2007 During high-dose corticosteroid treatment early after LTX, circulating MDC showed a lowered maturation status with decreased expression of human leucocyte antigen D-related (HLA-DR) and CD86 compared to pre-LTX values (P < 0.01). Leukotriene C4 54-57 C-C motif chemokine ligand 22 Homo sapiens 71-74 17576824-3 2007 ABCC molecules transport several endogenous substances, including leukotriene C4 (LTC4) and PGE2, which are involved in zymosan-induced inflammation. Leukotriene C4 66-80 ATP-binding cassette, sub-family A (ABC1), member 3 Mus musculus 0-4 17494643-2 2007 We previously described a mutation in cytoplasmic loop 7 (CL7) of MRP1, Pro1150Ala, which reduced leukotriene C(4) (LTC(4)) transport but increased 17beta-estradiol 17beta-d-glucuronide (E(2)17betaG) and methotrexate (MTX) transport. Leukotriene C4 98-111 ATP binding cassette subfamily C member 1 Homo sapiens 66-70 17397868-0 2007 Increased leukotriene c4 synthesis accompanied enhanced leukotriene c4 synthase expression and activities of ischemia-reperfusion-injured liver in rats. Leukotriene C4 10-24 leukotriene C4 synthase Rattus norvegicus 56-79 17359940-3 2007 Several endogenous cell metabolites, including the leukotriene C4 (LTC(4)) and glutathione (GSH) are substrates for ABCC1 protein. Leukotriene C4 51-65 ATP binding cassette subfamily C member 1 Homo sapiens 116-121 17306251-9 2007 In mouse mast cells, derived from a culture of bone marrow cells, responsiveness to heat shock, acetylsalicylic acid and exogenous or endogenous HSP70 was monitored by measuring leukotriene C4 release. Leukotriene C4 178-192 heat shock protein 1B Mus musculus 145-150 17391246-10 2007 Histamine release and histamine content per mast cell remained unchanged, whereas leukotriene C4 release decreased if mast cells were cultured with NGF or NT-3 in addition to SCF. Leukotriene C4 82-96 nerve growth factor Homo sapiens 148-151 17414718-3 2007 Intragraft FOXP3 increased within the first year after LTx, but not in blood. Leukotriene C4 55-58 forkhead box P3 Homo sapiens 11-16 17391246-10 2007 Histamine release and histamine content per mast cell remained unchanged, whereas leukotriene C4 release decreased if mast cells were cultured with NGF or NT-3 in addition to SCF. Leukotriene C4 82-96 3'-nucleotidase Homo sapiens 155-159 17188884-13 2007 RESULTS: In patients undergoing LTX for PPH, the ECMO support was directly extended into the post-operative period. Leukotriene C4 32-35 enolase 1 Homo sapiens 40-43 17169333-1 2007 Multidrug resistance related protein 1 (MRP1/ABCC1) is an ABC transporter protein related to the extrusion of reduced glutathione (GSH), oxidized glutathione (GSSG) and GSH-conjugates, as well as leukotriene C(4) and cyclopentane prostaglandins. Leukotriene C4 196-209 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 40-44 17169333-1 2007 Multidrug resistance related protein 1 (MRP1/ABCC1) is an ABC transporter protein related to the extrusion of reduced glutathione (GSH), oxidized glutathione (GSSG) and GSH-conjugates, as well as leukotriene C(4) and cyclopentane prostaglandins. Leukotriene C4 196-209 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 45-50 17194456-0 2007 Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats. Leukotriene C4 31-45 leukotriene C4 synthase Rattus norvegicus 71-94 16847695-2 2007 This localization supports the function of ABCC2 in the terminal excretion and detoxification of endogenous and xenobiotic organic anions, particularly in the unidirectional efflux of substances conjugated with glutathione, glucuronate, or sulfate, as exemplified by leukotriene C(4), bilirubin glucuronosides, and some steroid sulfates. Leukotriene C4 267-280 ATP binding cassette subfamily C member 2 Homo sapiens 43-48 16179583-0 2006 Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. Leukotriene C4 0-14 transforming growth factor beta 1 Homo sapiens 23-32 16868766-5 2007 MRP8 is able to transport a diverse range of lipophilic anions, including cyclic nucleotides, E(2)17betaG, steroid sulfates such as dehydroepiandrosterone (DHEAS) and E(1)S, glutathione conjugates such as leukotriene C4 and dinitrophenyl-S-glutathione, and monoanionic bile acids. Leukotriene C4 205-219 ATP binding cassette subfamily C member 11 Homo sapiens 0-4 17121932-1 2006 Multidrug resistance-associated protein 1 (MRP1) mediates the ATP-dependent efflux of endobiotics and xenobiotics, including estradiol 17-(beta-d-glucuronide), leukotriene C(4), and the reduced glutathione conjugate of 4-hydroxy-2-nonenal (HNE), a highly reactive product of lipid peroxidation. Leukotriene C4 160-173 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 0-41 17121932-1 2006 Multidrug resistance-associated protein 1 (MRP1) mediates the ATP-dependent efflux of endobiotics and xenobiotics, including estradiol 17-(beta-d-glucuronide), leukotriene C(4), and the reduced glutathione conjugate of 4-hydroxy-2-nonenal (HNE), a highly reactive product of lipid peroxidation. Leukotriene C4 160-173 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 43-47 16712615-7 2006 The serum AFP level decreased from 186 699 to 8 ng/mL in 11 months after LTx without local recurrence or distant metastasis. Leukotriene C4 73-76 alpha fetoprotein Homo sapiens 10-13 16481346-1 2006 Multidrug resistance protein-1 (MRP1) belongs to subfamily C of the ATP-binding cassette transporters, and exports leukotriene C(4) and organic anions including the fluorescent calcium indicator indo-1. Leukotriene C4 115-128 ATP binding cassette subfamily B member 1 Homo sapiens 0-30 16481346-1 2006 Multidrug resistance protein-1 (MRP1) belongs to subfamily C of the ATP-binding cassette transporters, and exports leukotriene C(4) and organic anions including the fluorescent calcium indicator indo-1. Leukotriene C4 115-128 ATP binding cassette subfamily B member 1 Homo sapiens 32-36 17063398-8 2006 In contrast, MRP inhibitors MK-571 and leukotriene C4 did not affect transport of paeoniflorin. Leukotriene C4 39-53 ATP binding cassette subfamily C member 1 Homo sapiens 13-16 17043982-5 2006 PATIENTS AND METHODS: Between 1989 and 2006 data of 115 patients receiving LTx for PBC at the Charite Campus Virchow were retrospectively analysed. Leukotriene C4 75-78 dihydrolipoamide S-acetyltransferase Homo sapiens 83-86 16424158-0 2006 Cutting edge: prostaglandin D2 enhances leukotriene C4 synthesis by eosinophils during allergic inflammation: synergistic in vivo role of endogenous eotaxin. Leukotriene C4 40-54 prostaglandin D2 synthase (brain) Mus musculus 14-30 15950430-3 2005 TNFalpha in combination with interferon-gamma reduced progesterone (P4) secretion, increased PGF2alpha and leukotriene C4 (LTC4) production, and induced apoptosis of the luteal cells in vitro. Leukotriene C4 107-121 tumor necrosis factor Bos taurus 0-8 16269045-1 2005 It has been shown that an induction therapy with the monoclonal anti-interleukin-2 receptor antibody basiliximab (Simulect) is capable to reduce the incidence of acute graft rejection in adult and pediatric liver transplantation (Ltx). Leukotriene C4 230-233 interleukin 2 Homo sapiens 69-82 16105987-0 2005 Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites. Leukotriene C4 163-177 ATP binding cassette subfamily B member 1 Homo sapiens 18-48 16105987-0 2005 Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites. Leukotriene C4 163-177 ATP binding cassette subfamily C member 1 Homo sapiens 50-55 17546512-4 2006 We determined the enhancement of Ang II-induced superoxide anion and leukotriene C(4) (LTC(4)) generation, membrane fluidity and cell-bound cholesterol content of neutrophils obtained from 12 control subjects, 11 patients with obesity (Ob), 10 patients with type 2 diabetes mellitus (t2-DM) and 12 patients with HC. Leukotriene C4 69-82 angiotensinogen Homo sapiens 33-39 16242117-4 2005 LTx enhanced cytokine-induced VCAM-1 expression and monocyte adhesion. Leukotriene C4 0-3 vascular cell adhesion molecule 1 Homo sapiens 30-36 16125525-2 2005 Results suggest that a 6-week-long Flu administration completely counteracted the AII-induced increase in superoxide anion and leukotriene C4 production of the neutrophils of patients with hypercholesterolemia. Leukotriene C4 127-141 angiotensinogen Homo sapiens 82-85 15950430-3 2005 TNFalpha in combination with interferon-gamma reduced progesterone (P4) secretion, increased PGF2alpha and leukotriene C4 (LTC4) production, and induced apoptosis of the luteal cells in vitro. Leukotriene C4 107-121 interferon gamma Bos taurus 29-45 15808662-11 2005 CONCLUSIONS: Plasma levels of L-FABP correlated well with WI and concomitant hepatocellular damage in LTx from NHBD. Leukotriene C4 102-105 fatty acid binding protein 1 Sus scrofa 30-36 16053335-5 2005 Multidrug-resistance-related protein (MRP) inhibitors (leukotriene C(4) plus MK-571, C(26)H(26)ClN(2)O(3)S(2)) significantly decreased the excretion of glucuronide and sulfate in mouse intestine (52-74% for glucuronide, 13-26% for sulfate) and in Caco-2 cells (92% for glucuronide, 37% for sulfate). Leukotriene C4 55-68 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 0-36 16053335-5 2005 Multidrug-resistance-related protein (MRP) inhibitors (leukotriene C(4) plus MK-571, C(26)H(26)ClN(2)O(3)S(2)) significantly decreased the excretion of glucuronide and sulfate in mouse intestine (52-74% for glucuronide, 13-26% for sulfate) and in Caco-2 cells (92% for glucuronide, 37% for sulfate). Leukotriene C4 55-68 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 38-41 15962102-4 2005 Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. Leukotriene C4 150-164 interleukin 4 Homo sapiens 55-59 15652236-1 2005 The human ATP-binding cassette (ABC) protein MRP1 causes resistance to many anticancer drugs and is also a primary active transporter of conjugated metabolites and endogenous organic anions, including leukotriene C(4) (LTC(4)) and glutathione (GSH). Leukotriene C4 201-214 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 10-30 15652236-1 2005 The human ATP-binding cassette (ABC) protein MRP1 causes resistance to many anticancer drugs and is also a primary active transporter of conjugated metabolites and endogenous organic anions, including leukotriene C(4) (LTC(4)) and glutathione (GSH). Leukotriene C4 201-214 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 32-35 15652236-1 2005 The human ATP-binding cassette (ABC) protein MRP1 causes resistance to many anticancer drugs and is also a primary active transporter of conjugated metabolites and endogenous organic anions, including leukotriene C(4) (LTC(4)) and glutathione (GSH). Leukotriene C4 201-214 ATP binding cassette subfamily C member 1 Homo sapiens 45-49 15455178-6 2005 Polarized excretion of most isoflavone conjugates was inhibited by the multidrug resistance-related protein (MRP) inhibitor leukotriene C(4) (0.1 micro M) and the organic anion transporter (OAT) inhibitor estrone sulfate (10 micro M). Leukotriene C4 124-137 chromosome 19 open reading frame 48 Homo sapiens 71-107 15455178-6 2005 Polarized excretion of most isoflavone conjugates was inhibited by the multidrug resistance-related protein (MRP) inhibitor leukotriene C(4) (0.1 micro M) and the organic anion transporter (OAT) inhibitor estrone sulfate (10 micro M). Leukotriene C4 124-137 chromosome 19 open reading frame 48 Homo sapiens 109-112 15628876-0 2005 The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. Leukotriene C4 4-18 ATP binding cassette subfamily B member 1 Homo sapiens 36-66 15628876-0 2005 The leucotriene C4 binding sites in multidrug resistance protein 1 (ABCC1) include the first membrane multiple spanning domain. Leukotriene C4 4-18 ATP binding cassette subfamily C member 1 Homo sapiens 68-73 16605134-3 2005 We now know that leukotriene C4 (LTC4) is formed when arachidonic acid is cleaved from membrane phospholipids, and metabolized to an epoxide intermediate, LTA4 that in turn is conjugated to reduced glutathione by an integral membrane protein, LTC4 synthase. Leukotriene C4 17-31 leukotriene C4 synthase Mus musculus 243-256 16605134-3 2005 We now know that leukotriene C4 (LTC4) is formed when arachidonic acid is cleaved from membrane phospholipids, and metabolized to an epoxide intermediate, LTA4 that in turn is conjugated to reduced glutathione by an integral membrane protein, LTC4 synthase. Leukotriene C4 33-37 leukotriene C4 synthase Mus musculus 243-256 15648254-3 2004 This work characterizes effects of Pluronic P85 on ATPase activities of Pgp, MRP1, and MRP2 drug efflux transport proteins and interaction of these proteins with their substrates, vinblastine, and leucotriene C4. Leukotriene C4 197-211 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 44-47 15386349-0 2004 RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Leukotriene C4 38-52 ralA binding protein 1 Homo sapiens 0-6 15386349-0 2004 RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Leukotriene C4 38-52 ralA binding protein 1 Homo sapiens 8-14 15516236-2 2004 We present the influence of retrograde reperfusion in LTX on the post-reperfusion syndrome (PRS). Leukotriene C4 54-57 PRS Homo sapiens 92-95 15516236-7 2004 Hemodynamic disturbances during LTX were uncommon, leading us to suppose that the incidence of PRS could be diminished with retrograde reperfusion. Leukotriene C4 32-35 PRS Homo sapiens 95-98 15648254-3 2004 This work characterizes effects of Pluronic P85 on ATPase activities of Pgp, MRP1, and MRP2 drug efflux transport proteins and interaction of these proteins with their substrates, vinblastine, and leucotriene C4. Leukotriene C4 197-211 ATP binding cassette subfamily C member 2 Homo sapiens 87-91 15344968-9 2004 In the LTX group, total cell counts, neutrophil percentages and IL-8 levels were much higher in SI than BAL (1.6 x 10(6)/mL, 65.5% and 54.2 ng/mL vs. 0.1 x 10(6)/mL, 3.0% and 0.01 ng/mL; p < 0.001). Leukotriene C4 7-10 C-X-C motif chemokine ligand 8 Homo sapiens 64-68 15245331-7 2004 UCB significantly inhibited the transport of LTC4 (leukotriene C4), a leukotriene substrate known to have high affinity for MRP1. Leukotriene C4 51-65 ATP binding cassette subfamily C member 1 Canis lupus familiaris 124-128 14693504-7 2004 In contrast, mast cell degranulators (compound 48/80, substance P) and mast cell mediators (histamine, leukotriene C(4)) reproduced the effect of NT. Leukotriene C4 103-116 neurotensin Rattus norvegicus 146-148 15161912-3 2004 The ATP binding cassette protein, multidrug resistance protein (MRP1/ABCC1), transports conjugated organic anions (e.g. leukotriene C(4)) and also co-transports certain unmodified xenobiotics (e.g. vincristine) with glutathione (GSH). Leukotriene C4 120-133 ATP binding cassette subfamily C member 1 Homo sapiens 64-68 15161912-3 2004 The ATP binding cassette protein, multidrug resistance protein (MRP1/ABCC1), transports conjugated organic anions (e.g. leukotriene C(4)) and also co-transports certain unmodified xenobiotics (e.g. vincristine) with glutathione (GSH). Leukotriene C4 120-133 ATP binding cassette subfamily C member 1 Homo sapiens 69-74 15161912-13 2004 As(GS)(3) transport experiments using MRP1 mutants with substrate specificities differing from wild-type MRP1 suggested a commonality in the substrate binding pockets of As(GS)(3) and leukotriene C(4). Leukotriene C4 184-197 ATP binding cassette subfamily C member 1 Homo sapiens 38-42 15161912-13 2004 As(GS)(3) transport experiments using MRP1 mutants with substrate specificities differing from wild-type MRP1 suggested a commonality in the substrate binding pockets of As(GS)(3) and leukotriene C(4). Leukotriene C4 184-197 ATP binding cassette subfamily C member 1 Homo sapiens 105-109 15020665-8 2004 Multidrug resistance-related protein inhibitors MK-571 (C26H26ClN2O3S2) and leukotriene C4 significantly decreased (maximal 80%) apical efflux of both conjugates. Leukotriene C4 76-90 chromosome 19 open reading frame 48 Homo sapiens 0-36 15083066-10 2004 We identified monoglucuronosyl bilirubin, bisglucuronosyl bilirubin and leukotriene C4 as substrates for both MRP3 and MRP3-ArgHis. Leukotriene C4 72-86 ATP binding cassette subfamily B member 4 Homo sapiens 110-114 14761945-3 2004 Zymosan-induced generation of leukotriene C4 and prostaglandin E2 was attenuated approximately 50% in peritoneal macrophages from group V sPLA2-null mice compared with macrophages from wild-type littermates. Leukotriene C4 30-44 phospholipase A2, group V Mus musculus 138-143 15063154-0 2004 Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells. Leukotriene C4 47-61 tachykinin 1 Mus musculus 0-11 15063154-4 2004 Primary cultured murine mast cells were stimulated with substance P and produced leukotriene C4, and prostaglandin D2 without the release of the granule-associated enzyme beta-hexosaminidase. Leukotriene C4 81-95 tachykinin 1 Mus musculus 56-67 15063154-6 2004 Leukotriene C4 and prostaglandin D2 production was blocked by genistein, a specific inhibitor of tyrosine kinases, and bisindolylmaleimide, a protein kinase C inhibitor, indicating a role for both phosphorylation pathways in the substance P-stimulated lipid mediator production. Leukotriene C4 0-14 tachykinin 1 Mus musculus 229-240 15083066-10 2004 We identified monoglucuronosyl bilirubin, bisglucuronosyl bilirubin and leukotriene C4 as substrates for both MRP3 and MRP3-ArgHis. Leukotriene C4 72-86 ATP binding cassette subfamily B member 4 Homo sapiens 119-123 15062036-7 2004 The levels of IL-6, ICAM-1 and P-selectin in serum were not found any difference between LTx group and PLC group, while the levels of IL-6, ICAM-1 and P-selectin in serum shown significant difference between LTx and healthy groups (P = 0.048, 0.000 and 0.025, respectively). Leukotriene C4 208-211 interleukin 6 Homo sapiens 134-138 15006547-6 2004 The labeling of the 190kDa MRP1 protein in membranes of HeLa-T5 cells was inhibited by substrates of MRP1 such as leukotriene C(4), vincrisine, and doxorubicin and by the inhibitor, MK571. Leukotriene C4 114-127 ATP binding cassette subfamily C member 1 Homo sapiens 27-31 15006547-6 2004 The labeling of the 190kDa MRP1 protein in membranes of HeLa-T5 cells was inhibited by substrates of MRP1 such as leukotriene C(4), vincrisine, and doxorubicin and by the inhibitor, MK571. Leukotriene C4 114-127 ATP binding cassette subfamily C member 1 Homo sapiens 101-105 15062036-7 2004 The levels of IL-6, ICAM-1 and P-selectin in serum were not found any difference between LTx group and PLC group, while the levels of IL-6, ICAM-1 and P-selectin in serum shown significant difference between LTx and healthy groups (P = 0.048, 0.000 and 0.025, respectively). Leukotriene C4 208-211 intercellular adhesion molecule 1 Homo sapiens 140-146 15062036-7 2004 The levels of IL-6, ICAM-1 and P-selectin in serum were not found any difference between LTx group and PLC group, while the levels of IL-6, ICAM-1 and P-selectin in serum shown significant difference between LTx and healthy groups (P = 0.048, 0.000 and 0.025, respectively). Leukotriene C4 208-211 selectin P Homo sapiens 151-161 14637132-4 2003 Rat MGST3 fails to convert leukotriene A(4) into leukotriene C(4), which in turn challenges the proposed catalytic role of a conserved Arg and Tyr residue for the leukotriene C(4) synthase reaction. Leukotriene C4 49-62 microsomal glutathione S-transferase 3 Rattus norvegicus 4-9 14529912-2 2003 We report seven patients who received LTx across ABO group for emergency indications. Leukotriene C4 38-41 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Homo sapiens 49-52 14640677-3 2003 The cytoplasmic loop (CL3) connecting this MSD, but apparently not the MSD itself, is required for MRP1 leukotriene C(4) (LTC(4)) transport activity, substrate binding and appropriate trafficking of the protein to the basolateral membrane. Leukotriene C4 104-117 ATP binding cassette subfamily C member 1 Canis lupus familiaris 99-103 12816731-1 2003 The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S). Leukotriene C4 38-52 leukotriene C4 synthase Homo sapiens 132-145 12816731-1 2003 The increased bronchial production of leukotriene C4 (LTC4) in asthma is assumed to derive from infiltrating eosinophils expressing LTC4-synthase (LTC4S). Leukotriene C4 38-52 leukotriene C4 synthase Homo sapiens 147-152 12893631-5 2003 Moreover, CHEL can block Mrp2-mediated leukotriene C4 uptake by membrane vesicles with an IC50 approximately 100 microM in the presence of GSH, but not S-methyl GSH or ophthalmic acid. Leukotriene C4 39-53 ATP binding cassette subfamily C member 2 Rattus norvegicus 25-29 14530366-5 2003 FMLP caused increased arachidonic acid (AA) release and secretion of leukotriene C(4) (LTC(4)). Leukotriene C4 69-82 formyl peptide receptor 1 Homo sapiens 0-4 14618263-4 2003 In contrast, dehydrosilybin strongly inhibited leukotriene C4 (LTC4) transport by membrane vesicles from MRP1-transfected cells, independently of reduced glutathione, and chemosensitized cell growth to vincristine. Leukotriene C4 47-61 ATP binding cassette subfamily C member 1 Homo sapiens 105-109 12948592-1 2003 The Multidrug Resistance Protein, MRP1 (ABCC1) confers drug resistance and transports organic anions such as leukotriene C(4) (LTC(4)) and 17beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG). Leukotriene C4 109-122 ATP binding cassette subfamily C member 1 Homo sapiens 34-38 12948592-1 2003 The Multidrug Resistance Protein, MRP1 (ABCC1) confers drug resistance and transports organic anions such as leukotriene C(4) (LTC(4)) and 17beta-estradiol 17-(beta-D-glucuronide) (E(2)17betaG). Leukotriene C4 109-122 ATP binding cassette subfamily C member 1 Homo sapiens 40-45 12797482-10 2003 Endothelial cell pretreatment with IL-4 or IL-1beta further increased leukotriene C4 release (1,789.1 and 2,895.1 pg x mL(-1), respectively), whereas pretreatment with IFN-gamma decreased it (293.7 pg x mL(-1)). Leukotriene C4 70-84 interleukin 4 Homo sapiens 35-39 12878209-1 2003 Leukotriene C(4) is a potent mediator of allergic and inflammatory reactions, and is formed from arachidonic acid and glutathione through the sequential action of 5-lipoxygenase and leukotriene C(4) synthase (LTCS). Leukotriene C4 0-13 arachidonate 5-lipoxygenase Mus musculus 163-177 12878209-1 2003 Leukotriene C(4) is a potent mediator of allergic and inflammatory reactions, and is formed from arachidonic acid and glutathione through the sequential action of 5-lipoxygenase and leukotriene C(4) synthase (LTCS). Leukotriene C4 0-13 leukotriene C4 synthase Mus musculus 182-207 12878209-1 2003 Leukotriene C(4) is a potent mediator of allergic and inflammatory reactions, and is formed from arachidonic acid and glutathione through the sequential action of 5-lipoxygenase and leukotriene C(4) synthase (LTCS). Leukotriene C4 0-13 leukotriene C4 synthase Mus musculus 209-213 12973112-7 2003 Both were able to detect the improvement of insulin sensitivity after LTx in the patients studied prospectively. Leukotriene C4 70-73 insulin Homo sapiens 44-51 12882448-8 2003 The results indicate that dexamethasone transcriptionally upregulates the activity of gamma-glutamyl transpeptidase-related enzyme in human bronchial epithelial cells, which accelerates inactivation of leukotriene C4 via conversion to leukotriene E4. Leukotriene C4 202-216 inactive glutathione hydrolase 2 Homo sapiens 86-115 12797482-10 2003 Endothelial cell pretreatment with IL-4 or IL-1beta further increased leukotriene C4 release (1,789.1 and 2,895.1 pg x mL(-1), respectively), whereas pretreatment with IFN-gamma decreased it (293.7 pg x mL(-1)). Leukotriene C4 70-84 interleukin 1 beta Homo sapiens 43-51 12641460-5 2003 Our results revealed that IAAGSH labeled MRP1 with high specificity, and binding was inhibited by MRP1 substrates leukotriene C(4) and MK571. Leukotriene C4 114-127 ATP binding cassette subfamily C member 1 Homo sapiens 41-45 12731862-3 2003 MRP1 also transports GSSG and GSH as well as conjugated organic anions, including leukotriene C(4) and 17beta-estradiol 17-(beta-D-glucuronide) and certain xenobiotics in association with GSH. Leukotriene C4 82-95 ATP binding cassette subfamily B member 1 Homo sapiens 0-4 12721111-12 2003 Whereas photolabelling of the mutant MRP1 R1202G was greatly reduced, it retained leukotriene C(4) (LTC(4)) transport activity and conferred Vincristine resistance in LLC-PK1 cells. Leukotriene C4 82-95 LOW QUALITY PROTEIN: multidrug resistance-associated protein 6 Sus scrofa 37-41 12682264-0 2003 Up-regulation of cysteinyl leukotriene 1 receptor by IL-13 enables human lung fibroblasts to respond to leukotriene C4 and produce eotaxin. Leukotriene C4 104-118 interleukin 13 Homo sapiens 53-58 12646261-0 2003 Glutathione, S-substituted glutathiones, and leukotriene C4 as substrates for peptidylglycine alpha-amidating monooxygenase. Leukotriene C4 45-59 peptidylglycine alpha-amidating monooxygenase Homo sapiens 78-123 12646261-3 2003 The addition of PAM to glutathione, a series of S-alkylated glutathiones, and leukotriene C(4) results in the consumption of O(2) and the production of the corresponding amidated peptide and glyoxylate. Leukotriene C4 78-91 peptidylglycine alpha-amidating monooxygenase Homo sapiens 16-19 12641460-5 2003 Our results revealed that IAAGSH labeled MRP1 with high specificity, and binding was inhibited by MRP1 substrates leukotriene C(4) and MK571. Leukotriene C4 114-127 ATP binding cassette subfamily C member 1 Homo sapiens 98-102 12398766-0 2003 Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1). Leukotriene C4 13-27 mitochondrial 37S ribosomal protein MRP1 Saccharomyces cerevisiae S288C 47-77 12398766-0 2003 Transport of leukotriene C4 by a cysteine-less multidrug resistance protein 1 (MRP1). Leukotriene C4 13-27 mitochondrial 37S ribosomal protein MRP1 Saccharomyces cerevisiae S288C 79-83 12398766-5 2003 Compared with full-length MRP1, the K m for leukotriene C4 transport by CL tMRP1 was increased approximately 3-fold, while V max was not affected. Leukotriene C4 44-58 mitochondrial 37S ribosomal protein MRP1 Saccharomyces cerevisiae S288C 26-30 12589355-9 2003 Subjects were genotyped for leukotriene C(4) (LTC(4)) synthase C-to-A promoter polymorphism. Leukotriene C4 28-41 leukotriene C4 synthase Homo sapiens 46-62 12529506-7 2003 Cross-linking of LIR7 with plate-bound antibody elicited the dose- and time-dependent release of eosinophil-derived neurotoxin and leukotriene C(4). Leukotriene C4 131-144 leukocyte immunoglobulin like receptor A2 Homo sapiens 17-21 12529506-8 2003 Eosinophils activated with antibodies to LIR7 embedded in gel-phase EliCell preparations showed leukotriene C(4) generation at the nuclear envelope and the release of IL-12 but not IL-4 by vesicular transport. Leukotriene C4 96-109 leukocyte immunoglobulin like receptor A2 Homo sapiens 41-45 12388190-1 2003 Multidrug resistance protein 3 (MRP3) is an ATP-dependent transporter of 17beta-estradiol 17beta(d-glucuronide) (E(2)17betaG), leukotriene C(4) (LTC(4)), methotrexate, and the bile salts taurocholate and glycocholate. Leukotriene C4 127-140 ATP binding cassette subfamily B member 4 Homo sapiens 0-30 12388190-1 2003 Multidrug resistance protein 3 (MRP3) is an ATP-dependent transporter of 17beta-estradiol 17beta(d-glucuronide) (E(2)17betaG), leukotriene C(4) (LTC(4)), methotrexate, and the bile salts taurocholate and glycocholate. Leukotriene C4 127-140 ATP binding cassette subfamily B member 4 Homo sapiens 32-36 12163373-3 2002 Here we show that in vivo GGL, and not GGT as previously believed, is primarily responsible for conversion of leukotriene C(4) to leukotriene D(4), the most potent of the cysteinyl leukotrienes and the immediate precursor of leukotriene E(4). Leukotriene C4 110-123 gamma-glutamyltransferase 5 Mus musculus 26-29 12023288-1 2002 Leukotriene C(4) (LTC(4)) synthase conjugates LTA(4) with GSH to form LTC(4). Leukotriene C4 0-13 leukotriene C4 synthase Homo sapiens 18-34 12636164-2 2003 The objective of this study is to evaluate the lung deposition and systemic absorption of aCsA after aerosolized cyclosporine administration in LTx patients in the immediate postoperative period. Leukotriene C4 144-147 acyl-CoA synthetase short chain family member 2 Homo sapiens 90-94 14587429-4 2003 The aim of this study was to investigate the influence of IFN-gamma on leukotriene C4 (LTC4) production by peripheral blood leukocytes isolated from the patients suffering from perennial allergic rhinitis caused by allergy to mites. Leukotriene C4 71-85 interferon gamma Homo sapiens 58-67 12388549-2 2002 In tumor cells, MRP1 confers resistance to a broad spectrum of drugs, but in normal cells, it functions as a primary active transporter of organic anions such as leukotriene C(4) and 17beta-estradiol 17beta-(D-glucuronide). Leukotriene C4 162-175 ATP binding cassette subfamily C member 1 Homo sapiens 16-20 12453875-6 2002 SCF-activated eosinophils degranulate and release eosinophil peroxidase and leukotriene C(4) in a dose-dependent manner. Leukotriene C4 76-89 kit ligand Mus musculus 0-3 12434394-7 2002 Multidrug resistance related protein (MRP) inhibitor leukotriene C(4) only decreased (p < 0.05) P(BA) of ciprofloxacin but not that of CNV97100. Leukotriene C4 53-66 chromosome 19 open reading frame 48 Homo sapiens 0-36 12434394-7 2002 Multidrug resistance related protein (MRP) inhibitor leukotriene C(4) only decreased (p < 0.05) P(BA) of ciprofloxacin but not that of CNV97100. Leukotriene C4 53-66 ATP binding cassette subfamily C member 1 Homo sapiens 38-41 12235150-7 2002 Mutation analyses of the two cysteines in human MRP1 revealed that the Cys(7) residue is critical for the MRP1-mediated drug resistance and leukotriene C(4) transport activity. Leukotriene C4 140-153 ATP binding cassette subfamily C member 1 Homo sapiens 48-52 12186871-2 2002 MRP1 also mediates transport of organic anions such as leukotriene C(4) (LTC(4)), 17beta-estradiol 17-(beta-d-glucuronide) (E(2)17betaG), estrone 3-sulfate, methotrexate (MTX), and GSH. Leukotriene C4 55-68 ATP binding cassette subfamily C member 1 Homo sapiens 0-4 12186871-2 2002 MRP1 also mediates transport of organic anions such as leukotriene C(4) (LTC(4)), 17beta-estradiol 17-(beta-d-glucuronide) (E(2)17betaG), estrone 3-sulfate, methotrexate (MTX), and GSH. Leukotriene C4 55-68 metaxin 1 Homo sapiens 171-174 12163373-7 2002 Further, GGL-deficient mice show leukotriene C(4) accumulation and significantly more airway hyperreponsiveness than wild-type mice in the experimental asthma, and induction of asthma results in increased GGL protein levels and enzymatic activity. Leukotriene C4 33-46 gamma-glutamyltransferase 5 Mus musculus 9-12 12149701-7 2002 In 6 patients undergoing liver transplantation (LTx), Plt and P-TPO after LTx was 157.5 +/- 83.5 x 10(3) and 143.5 +/- 75.2, respectively, which were significantly higher than those before LTx (55.0 +/- 15.6 x 10(3)/mm3 and 53.2 +/- 32.9 pg/mL). Leukotriene C4 48-51 thyroid peroxidase Homo sapiens 64-67 12149701-7 2002 In 6 patients undergoing liver transplantation (LTx), Plt and P-TPO after LTx was 157.5 +/- 83.5 x 10(3) and 143.5 +/- 75.2, respectively, which were significantly higher than those before LTx (55.0 +/- 15.6 x 10(3)/mm3 and 53.2 +/- 32.9 pg/mL). Leukotriene C4 74-77 thyroid peroxidase Homo sapiens 64-67 11934880-1 2002 Platelet activating factor (PAF) interacts with cell surface G protein-coupled receptors on leukocytes to induce degranulation, leukotriene C(4) (LTC(4)) generation, and chemokine CCL2 production. Leukotriene C4 128-141 PCNA clamp associated factor Rattus norvegicus 28-31 12097406-10 2002 Immobilized lactoferrin also stimulated release of eosinophil-derived neurotoxin and low levels of leukotriene C4 production; the latter was significantly enhanced in the presence of 100 pg/ml GM-CSF. Leukotriene C4 99-113 colony stimulating factor 2 Homo sapiens 193-199 12042670-4 2002 Transport experiments with membrane vesicles prepared from transfected human embryonic kidney cells and HeLa cells revealed a two-fold reduction in the ATP-dependent transport of the MRP1 substrates, leukotriene C4 (LTC4) and oestrone sulphate. Leukotriene C4 200-214 ATP binding cassette subfamily C member 1 Homo sapiens 183-187 11971026-0 2002 IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. Leukotriene C4 15-28 interleukin 16 Homo sapiens 0-5 11880368-4 2002 We found that glutathione conjugates, including leukotriene C(4) and N-ethylmaleimide S-glutathione (NEM-GS), were actively transported by human ABCC6. Leukotriene C4 48-61 ATP binding cassette subfamily C member 6 Homo sapiens 145-150 11971026-2 2002 We evaluated the means by which IL-16, a recognized eosinophil chemoattractant, might act on eosinophils to affect their capacity to release leukotriene C(4) (LTC(4)) or their preformed stores of chemokines (eotaxin, RANTES) or Th1 (IL-12) or Th2 (IL-4) cytokines. Leukotriene C4 141-154 interleukin 16 Homo sapiens 32-37 11850343-6 2002 The CD4/CD8 ratio increased significantly from 0.32 (0.11-0.46) just posttransplantation to 0.62 (0.16-4.27) the second year after LTX. Leukotriene C4 131-134 CD4 molecule Homo sapiens 4-7 11748225-3 2002 The basal-to-apical transport of 17 beta estradiol 17 beta-d-glucuronide (E(2)17 beta G), pravastatin, and leukotriene C(4) (LTC(4)), which are substrates of OATP2 and MRP2, was significantly higher than that in the opposite direction in the double-transfected cells. Leukotriene C4 107-120 solute carrier organic anion transporter family member 1B1 Homo sapiens 158-163 11748225-3 2002 The basal-to-apical transport of 17 beta estradiol 17 beta-d-glucuronide (E(2)17 beta G), pravastatin, and leukotriene C(4) (LTC(4)), which are substrates of OATP2 and MRP2, was significantly higher than that in the opposite direction in the double-transfected cells. Leukotriene C4 107-120 ATP binding cassette subfamily C member 2 Canis lupus familiaris 168-172 11901101-7 2002 Moderate inhibition of etoposide efflux by leukotriene C4 (LTC4) was observed in MDCKII-cMOAT cells. Leukotriene C4 43-57 ATP binding cassette subfamily C member 2 Homo sapiens 88-93 11850343-6 2002 The CD4/CD8 ratio increased significantly from 0.32 (0.11-0.46) just posttransplantation to 0.62 (0.16-4.27) the second year after LTX. Leukotriene C4 131-134 CD8a molecule Homo sapiens 8-11 11790658-6 2002 AP and ACE activities in lavage after 2 h of reperfusion were significantly elevated in animals that underwent LTX (AP: 60 +/- 28 IU/L; ACE: 1.39 +/- 1.13 IU/L) compared with animals with BAR (AP: 33 +/- 29 IU/L; ACE: 0.35 +/- 0.6 IU/L; p < 0.05) and with control animals (AP: 13.58 +/- 11.0 IU/L; ACE: 0.06 +/- 0.14 IU/L; p < 0.01). Leukotriene C4 111-114 angiotensin I converting enzyme Canis lupus familiaris 7-10 11790658-6 2002 AP and ACE activities in lavage after 2 h of reperfusion were significantly elevated in animals that underwent LTX (AP: 60 +/- 28 IU/L; ACE: 1.39 +/- 1.13 IU/L) compared with animals with BAR (AP: 33 +/- 29 IU/L; ACE: 0.35 +/- 0.6 IU/L; p < 0.05) and with control animals (AP: 13.58 +/- 11.0 IU/L; ACE: 0.06 +/- 0.14 IU/L; p < 0.01). Leukotriene C4 111-114 angiotensin I converting enzyme Canis lupus familiaris 136-139 11790658-6 2002 AP and ACE activities in lavage after 2 h of reperfusion were significantly elevated in animals that underwent LTX (AP: 60 +/- 28 IU/L; ACE: 1.39 +/- 1.13 IU/L) compared with animals with BAR (AP: 33 +/- 29 IU/L; ACE: 0.35 +/- 0.6 IU/L; p < 0.05) and with control animals (AP: 13.58 +/- 11.0 IU/L; ACE: 0.06 +/- 0.14 IU/L; p < 0.01). Leukotriene C4 111-114 angiotensin I converting enzyme Canis lupus familiaris 136-139 11790658-6 2002 AP and ACE activities in lavage after 2 h of reperfusion were significantly elevated in animals that underwent LTX (AP: 60 +/- 28 IU/L; ACE: 1.39 +/- 1.13 IU/L) compared with animals with BAR (AP: 33 +/- 29 IU/L; ACE: 0.35 +/- 0.6 IU/L; p < 0.05) and with control animals (AP: 13.58 +/- 11.0 IU/L; ACE: 0.06 +/- 0.14 IU/L; p < 0.01). Leukotriene C4 111-114 angiotensin I converting enzyme Canis lupus familiaris 136-139 12545192-3 2002 Proteoliposomes reconstituted with purified RLIP76 catalyze ATP-dependent, saturable transport of DOX, as well as of glutathione-conjugates including leukotrienes (LTC4) and the GSH-conjugate of 4-hydroxynonenal (GS-HNE). Leukotriene C4 164-168 ralA binding protein 1 Homo sapiens 44-50 11581266-5 2001 Membrane vesicles from infected insect cells expressing MRP3 mediated ATP-dependent transport of estradiol 17-beta-D-glucuronide, leukotriene C(4), dinitrophenyl S-glutathione but not glutathione itself, and etoposide glucuronide, a major metabolite of etoposide in vivo. Leukotriene C4 130-143 ATP binding cassette subfamily C member 3 Homo sapiens 56-60 11591709-9 2001 Intracellular calcium mobilization in response to cysteinyl leukotriene administration was detected in human embryonic kidney 293T cells transfected with recombinant mCysLT(2)R with a rank order of potency leukotriene C(4)(LTC(4) ) = LTD(4)>>LTE(4). Leukotriene C4 206-219 cysteinyl leukotriene receptor 2 Mus musculus 166-176 11751988-3 2002 After IgE receptor engagement, bone marrow mast cells from STAT6(-/-) mice exhibited normal histamine and leukotriene C(4) release, but their cytokine release was markedly reduced. Leukotriene C4 106-119 signal transducer and activator of transcription 6 Mus musculus 59-64 11595704-8 2001 Membrane vesicles prepared from ATL cells with high expression of MRP1 mRNA showed a higher ATP-dependent leukotriene C(4) uptake than did those with low expression of MRP1 mRNA. Leukotriene C4 106-122 ATP binding cassette subfamily C member 1 Homo sapiens 66-70 11685683-9 2001 In 4 patients undergoing liver transplantation (LTx), ET-1 after LTx was lower than that before LTx (P <.05). Leukotriene C4 48-51 endothelin 1 Homo sapiens 54-58 11685683-9 2001 In 4 patients undergoing liver transplantation (LTx), ET-1 after LTx was lower than that before LTx (P <.05). Leukotriene C4 65-68 endothelin 1 Homo sapiens 54-58 11685683-9 2001 In 4 patients undergoing liver transplantation (LTx), ET-1 after LTx was lower than that before LTx (P <.05). Leukotriene C4 65-68 endothelin 1 Homo sapiens 54-58 11713643-5 2001 Similar to Oatp1 and Oatp2, Oatp4 is a multispecific transporter with high affinities for bromosulfophthalein, dehydroepiandrosterone sulfate, leukotriene C4, and anionic peptides. Leukotriene C4 143-157 solute carrier organic anion transporter family, member 1a1 Rattus norvegicus 11-16 11713643-5 2001 Similar to Oatp1 and Oatp2, Oatp4 is a multispecific transporter with high affinities for bromosulfophthalein, dehydroepiandrosterone sulfate, leukotriene C4, and anionic peptides. Leukotriene C4 143-157 solute carrier organic anion transporter family, member 1a4 Rattus norvegicus 21-26 11713643-5 2001 Similar to Oatp1 and Oatp2, Oatp4 is a multispecific transporter with high affinities for bromosulfophthalein, dehydroepiandrosterone sulfate, leukotriene C4, and anionic peptides. Leukotriene C4 143-157 solute carrier organic anion transporter family member 1B2 Rattus norvegicus 28-33 11704473-8 2001 CONCLUSIONS: These data underline the possible contribution of proteases such as MMP-9 to chronic transplant rejection, and suggest that an imbalance of MMP-9 and TIMP-1 may be involved in the pathogenesis of airway obstruction after LTx. Leukotriene C4 234-237 matrix metallopeptidase 9 Homo sapiens 153-158 11704473-8 2001 CONCLUSIONS: These data underline the possible contribution of proteases such as MMP-9 to chronic transplant rejection, and suggest that an imbalance of MMP-9 and TIMP-1 may be involved in the pathogenesis of airway obstruction after LTx. Leukotriene C4 234-237 TIMP metallopeptidase inhibitor 1 Homo sapiens 163-169 11507101-0 2001 Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein. Leukotriene C4 31-45 ATP binding cassette subfamily B member 1 Homo sapiens 55-85 11437348-8 2001 In erythrocyte inside-out vesicles (IOVs) coated with antibodies against RLIP76, a dose-dependent inhibition of the ATP-dependent transport of DOX and GS-E, including S-(dinitrophenyl)glutathione (DNP-SG), leukotriene C(4), and the GSH conjugate of 4-hydroxynonenal, was observed with a maximal inhibition of about 70%. Leukotriene C4 206-219 ralA binding protein 1 Homo sapiens 73-79 11544458-2 2001 This neurotrophin is found at high levels in the serum of asthmatic individuals, is released during allergic reactions, and is reported to augment in vitro histamine and leukotriene C4 release by human basophils. Leukotriene C4 170-184 brain derived neurotrophic factor Homo sapiens 5-17 11274187-0 2001 Extranuclear lipid bodies, elicited by CCR3-mediated signaling pathways, are the sites of chemokine-enhanced leukotriene C4 production in eosinophils and basophils. Leukotriene C4 109-123 C-C motif chemokine receptor 3 Homo sapiens 39-43 11274187-2 2001 We show that the C-C chemokines, eotaxin and RANTES (regulated upon activation normal T cell expressed and secreted), activate eosinophils and basophils for enhanced leukotriene C(4) (LTC(4)) generation by distinct signaling and compartmentalization mechanisms involving the induced formation of new cytoplasmic lipid body organelles. Leukotriene C4 166-179 C-C motif chemokine ligand 11 Homo sapiens 33-40 11274187-2 2001 We show that the C-C chemokines, eotaxin and RANTES (regulated upon activation normal T cell expressed and secreted), activate eosinophils and basophils for enhanced leukotriene C(4) (LTC(4)) generation by distinct signaling and compartmentalization mechanisms involving the induced formation of new cytoplasmic lipid body organelles. Leukotriene C4 166-179 C-C motif chemokine ligand 5 Homo sapiens 45-51 11274187-2 2001 We show that the C-C chemokines, eotaxin and RANTES (regulated upon activation normal T cell expressed and secreted), activate eosinophils and basophils for enhanced leukotriene C(4) (LTC(4)) generation by distinct signaling and compartmentalization mechanisms involving the induced formation of new cytoplasmic lipid body organelles. Leukotriene C4 166-179 C-C motif chemokine ligand 5 Homo sapiens 53-115 11322876-0 2001 Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. Leukotriene C4 48-62 microsomal glutathione S-transferase 1 Homo sapiens 67-103 11278867-3 2001 In addition, in contrast to wild-type MRP1, leukotriene C(4) transport by the W1246C-MRP1 protein was no longer inhibitable by E(2)17betaG, indicating that the mutant protein had lost the ability to bind the glucuronide. Leukotriene C4 44-57 ATP binding cassette subfamily C member 1 Homo sapiens 85-89 11278596-5 2001 This mutation created a protein that conferred resistance to doxorubicin without affecting vincristine resistance, or the ability of mrp1 to transport leukotriene C(4) (LTC(4)) and 17beta-estradiol 17-(beta-d-glucuronide) (E(2)17betaG). Leukotriene C4 151-164 ATP binding cassette subfamily B member 1 Homo sapiens 133-137 11306701-1 2001 The 190-kDa phosphoglycoprotein multidrug resistance protein 1 (MRP1) (ABCC1) confers resistance to a broad spectrum of anticancer drugs and also actively transports certain xenobiotics with reduced glutathione (GSH) (cotransport) as well as conjugated organic anions such as leukotriene C(4) (LTC(4)). Leukotriene C4 276-289 ATP binding cassette subfamily B member 1 Homo sapiens 32-62 11306701-1 2001 The 190-kDa phosphoglycoprotein multidrug resistance protein 1 (MRP1) (ABCC1) confers resistance to a broad spectrum of anticancer drugs and also actively transports certain xenobiotics with reduced glutathione (GSH) (cotransport) as well as conjugated organic anions such as leukotriene C(4) (LTC(4)). Leukotriene C4 276-289 ATP binding cassette subfamily B member 1 Homo sapiens 64-68 11306701-1 2001 The 190-kDa phosphoglycoprotein multidrug resistance protein 1 (MRP1) (ABCC1) confers resistance to a broad spectrum of anticancer drugs and also actively transports certain xenobiotics with reduced glutathione (GSH) (cotransport) as well as conjugated organic anions such as leukotriene C(4) (LTC(4)). Leukotriene C4 276-289 ATP binding cassette subfamily C member 1 Homo sapiens 71-76 11721885-7 2001 Transport of the MRP1 substrates leukotriene C4, 17beta-estradiol 17beta-(D)-glucuronide, and estrone sulfate by membrane vesicles prepared from transiently transfected HEKSV293T cells was comparable to that of wild-type MRP1. Leukotriene C4 33-47 ATP binding cassette subfamily B member 1 Homo sapiens 17-21 11106649-5 2001 In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor. Leukotriene C4 289-302 glypican 1 Homo sapiens 43-51 11106649-5 2001 In rat mastocytoma RBL-2H3 cells that lack glypican, sPLA(2)-V and -X, which are unique among sPLA(2)s in being able to hydrolyze phosphatidylcholine-rich membranes, act most likely on the extracellular face of the plasma membrane to markedly augment IgE-dependent immediate production of leukotriene C(4) and platelet-activating factor. Leukotriene C4 289-302 phospholipase A2 group IIA Rattus norvegicus 53-69 11102445-9 2001 We found that estradiol and estrone 3-sulfate alone were poor competitors of MRP1-mediated transport of the cysteinyl leukotriene, leukotriene C(4). Leukotriene C4 131-144 ATP binding cassette subfamily B member 1 Homo sapiens 77-81 10973807-6 2000 moat1 transports prostaglandin D(2) (K(m); 35.5 nM), leukotriene C(4) (K(m); 3.2 microM) and taurocholate (K(m); 17.6 microM) in a sodium-independent manner. Leukotriene C4 53-66 solute carrier organic anion transporter family, member 2b1 Rattus norvegicus 0-5 10979966-1 2000 Cross-linking of IgE or a bacterial product (f-Met-Leu-Phe; FMLP) induces the release of leukotriene C4 (LTC4) and histamine in human basophils. Leukotriene C4 89-103 formyl peptide receptor 1 Homo sapiens 60-64 10973801-0 2000 Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1. Leukotriene C4 75-88 ATP binding cassette subfamily C member 1 Homo sapiens 148-152 10973801-3 2000 We have now examined 20 sulfur-containing verapamil analogs for their ability to inhibit MRP1-mediated leukotriene C(4) (LTC(4)) transport and stimulate GSH uptake into inside-out membrane vesicles. Leukotriene C4 103-116 ATP binding cassette subfamily C member 1 Homo sapiens 89-93 10973807-0 2000 Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Leukotriene C4 110-123 solute carrier organic anion transporter family, member 2b1 Rattus norvegicus 66-71 11093153-10 2000 Though only Delta(12)-PGJ(2) and 15d-PGJ(2) revealed an inhibitory effect on histamine release, leukotriene C(4) release from HCMC was suppressed by all tested PPARgamma agonists. Leukotriene C4 96-109 peroxisome proliferator activated receptor gamma Homo sapiens 160-169 11114332-2 2000 Here, we show that DC migration from skin to lymph nodes utilizes the leukotriene C(4) (LTC(4)) transporter multidrug resistance-associated protein 1 (MRP1). Leukotriene C4 70-83 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 151-155 11029586-12 2000 NS-398, sulindac sulfide and leukotriene C4 were all found to inhibit PGES activity with IC50 values of 20 microM, 80 microM and 5 microM, respectively. Leukotriene C4 29-43 prostaglandin E synthase Homo sapiens 70-74 11097346-4 2000 Leukotriene C4 is an important endogenous substrate for MRP1. Leukotriene C4 0-14 ATP binding cassette subfamily C member 1 Homo sapiens 56-60 10880748-6 2000 In contrast to IL-3 grown cells, SCF/IL-4-exposed cells showed functional responsiveness to release beta-hexosaminidase (42.25% +/- 1.46% at SP concentration of 100 microM) and produce leukotriene C(4) (LTC(4)) (7.4 +/- 1.5 ng/10(6) cells)/prostaglandin D(2) (PGD(2)) (2.0 +/- 0.3 ng/10(6) cells) upon stimulation by SP. Leukotriene C4 185-198 KIT ligand Rattus norvegicus 33-36 11028668-10 2000 These results suggest that leukotriene C4 production by leukocytes is associated with immunoglobulin E-mediated allergy and asthma exacerbations, and further that generation of leukotriene B4 is closely related to bronchial hyperresponsiveness in patients with asthma. Leukotriene C4 27-41 immunoglobulin heavy constant epsilon Homo sapiens 86-102 10934231-2 2000 Leukotriene B(4) (LTB(4)) and leukotriene C(4) (LTC(4)) act through G protein-coupled receptors LTB(4) receptor (BLTR) and Cys-LTR, respectively. Leukotriene C4 30-43 leukotriene B4 receptor 1 Mus musculus 96-111 10934231-2 2000 Leukotriene B(4) (LTB(4)) and leukotriene C(4) (LTC(4)) act through G protein-coupled receptors LTB(4) receptor (BLTR) and Cys-LTR, respectively. Leukotriene C4 30-43 leukotriene B4 receptor 1 Mus musculus 113-117 10835322-1 2000 We assessed the effect of anti-CD3-stimulated secretion of cultured human Th1- and Th2-like cells on leukotriene C(4) (LTC(4)) secretion in isolated human eosinophils. Leukotriene C4 101-114 negative elongation factor complex member C/D Homo sapiens 74-77 11083457-2 2000 In platelets GGT converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) and is involved in glutathione metabolism. Leukotriene C4 26-40 gamma-glutamyltransferase 1 Homo sapiens 13-16 10913337-5 2000 In human embryonic kidney 293 cells that express the PSEC0146 cDNA, leukotriene C(4) (LTC(4)) and leukotriene D(4) (LTD(4)) induce equal increases in intracellular calcium mobilization; these increases are not affected by CysLT(1) antagonists. Leukotriene C4 68-81 cysteinyl leukotriene receptor 2 Homo sapiens 53-61 10913337-5 2000 In human embryonic kidney 293 cells that express the PSEC0146 cDNA, leukotriene C(4) (LTC(4)) and leukotriene D(4) (LTD(4)) induce equal increases in intracellular calcium mobilization; these increases are not affected by CysLT(1) antagonists. Leukotriene C4 68-81 cysteinyl leukotriene receptor 1 Homo sapiens 222-230 10839982-5 2000 The application of exogenous AA increased levels of ROS but the effect was dependent on the further metabolism of AA to leukotrienes C(4)/D(4)/E(4) by 5-lipoxygenase. Leukotriene C4 120-134 arachidonate 5-lipoxygenase Rattus norvegicus 151-165 10880748-6 2000 In contrast to IL-3 grown cells, SCF/IL-4-exposed cells showed functional responsiveness to release beta-hexosaminidase (42.25% +/- 1.46% at SP concentration of 100 microM) and produce leukotriene C(4) (LTC(4)) (7.4 +/- 1.5 ng/10(6) cells)/prostaglandin D(2) (PGD(2)) (2.0 +/- 0.3 ng/10(6) cells) upon stimulation by SP. Leukotriene C4 185-198 interleukin 4 Rattus norvegicus 37-41 10753897-0 2000 ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. Leukotriene C4 115-128 mitogen-activated protein kinase 3 Homo sapiens 0-4 10821682-7 2000 Furthermore, a molar excess of leukotriene C(4), doxorubicin, colchicine, and other quinoline-based drugs, including MK571, inhibited the photoaffinity labeling of the MRP. Leukotriene C4 31-44 ATP binding cassette subfamily C member 1 Homo sapiens 168-171 10753897-0 2000 ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. Leukotriene C4 115-128 mitogen-activated protein kinase 1 Homo sapiens 9-13 10753897-0 2000 ERK1 and ERK2 activation by chemotactic factors in human eosinophils is interleukin 5-dependent and contributes to leukotriene C(4) biosynthesis. Leukotriene C4 115-128 interleukin 5 Homo sapiens 72-85 10753897-7 2000 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. Leukotriene C4 202-215 mitogen-activated protein kinase 1 Homo sapiens 28-31 10753897-7 2000 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. Leukotriene C4 202-215 interleukin 5 Homo sapiens 46-50 10753897-7 2000 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. Leukotriene C4 202-215 mitogen-activated protein kinase 1 Homo sapiens 110-113 10753897-7 2000 The biological relevance of ERK activation to IL-5 priming is supported by the observation that inhibition of ERK activity by treatment with the MEK inhibitors PD98059 or U0126 inhibited the release of leukotriene C(4) stimulated by fMet-Leu-Phe in IL-5-primed eosinophils. Leukotriene C4 202-215 interleukin 5 Homo sapiens 249-253 10760098-7 2000 The high-affinity substrate leukotriene C4 and the inhibitor of MRP-mediated transport, MK571, inhibited MRP2-mediated transport of PAH (100 nmol/L) with IC50 values of 3.3 and 4.0 micromol/L, respectively. Leukotriene C4 28-42 ATP binding cassette subfamily C member 2 Homo sapiens 105-109 11450027-7 2000 Sodium fluorescein clearance across HCEC monolayers exposed to leukotriene C4 in the presence of the GGTP inhibitor, acivicin (1 microM), or after in vitro ischemia was increased by 60% and 30%, respectively, suggesting that oxidative stress and loss of GGTP may "unmask" BBB permeabilizing actions of leukotrienes. Leukotriene C4 63-77 inactive glutathione hydrolase 2 Homo sapiens 101-105 10706691-0 2000 Dual phase priming by IL-3 for leukotriene C4 generation in human basophils: difference in characteristics between acute and late priming effects. Leukotriene C4 31-45 interleukin 3 Homo sapiens 22-26 10631301-3 2000 The uptake of leukotriene C(4) (LTC(4)), a substrate for multidrug resistance protein (MRP), was concentration-dependently inhibited by the leukotriene antagonist MK571 (IC(50)=110+/-20 nM), but cGMP was unable to inhibit LTC(4) uptake. Leukotriene C4 14-27 ATP binding cassette subfamily C member 1 Homo sapiens 57-85 10631301-3 2000 The uptake of leukotriene C(4) (LTC(4)), a substrate for multidrug resistance protein (MRP), was concentration-dependently inhibited by the leukotriene antagonist MK571 (IC(50)=110+/-20 nM), but cGMP was unable to inhibit LTC(4) uptake. Leukotriene C4 14-27 ATP binding cassette subfamily C member 1 Homo sapiens 87-90 10727523-3 2000 Both MRP1 and MRP2 actively transported leukotriene C(4) and N-ethylmaleimide glutathione (NEM-GS), although the relative affinity of MRP2 for these substrates was found to be significantly lower than that of MRP1. Leukotriene C4 40-53 ATP binding cassette subfamily C member 1 Homo sapiens 5-9 10727523-3 2000 Both MRP1 and MRP2 actively transported leukotriene C(4) and N-ethylmaleimide glutathione (NEM-GS), although the relative affinity of MRP2 for these substrates was found to be significantly lower than that of MRP1. Leukotriene C4 40-53 ATP binding cassette subfamily C member 2 Homo sapiens 14-18 10727523-3 2000 Both MRP1 and MRP2 actively transported leukotriene C(4) and N-ethylmaleimide glutathione (NEM-GS), although the relative affinity of MRP2 for these substrates was found to be significantly lower than that of MRP1. Leukotriene C4 40-53 ATP binding cassette subfamily C member 2 Homo sapiens 134-138 10727523-3 2000 Both MRP1 and MRP2 actively transported leukotriene C(4) and N-ethylmaleimide glutathione (NEM-GS), although the relative affinity of MRP2 for these substrates was found to be significantly lower than that of MRP1. Leukotriene C4 40-53 ATP binding cassette subfamily C member 1 Homo sapiens 209-213 10698703-6 2000 Addition of 5-lipoxygenase products 5-hydroperoxyeicosatetraenoic acid (5-HPETE) and leukotriene B(4), but not 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene C(4), restored LPA-stimulated H(2)O(2) release in cells treated with the lipoxygenase inhibitors nordihydroguaiaretic acid and Zileuton. Leukotriene C4 155-168 arachidonate 5-lipoxygenase Homo sapiens 12-26 11450027-7 2000 Sodium fluorescein clearance across HCEC monolayers exposed to leukotriene C4 in the presence of the GGTP inhibitor, acivicin (1 microM), or after in vitro ischemia was increased by 60% and 30%, respectively, suggesting that oxidative stress and loss of GGTP may "unmask" BBB permeabilizing actions of leukotrienes. Leukotriene C4 63-77 inactive glutathione hydrolase 2 Homo sapiens 254-258 10561698-10 1999 CDP-choline may act by increasing PtdCho synthesis via two pathways: (1) conversion of 1, 2-diacylglycerol to PtdCho, and (2) biosynthesis of S-adenosyl-L-methionine, thus stabilizing the membrane and reducing AA release and metabolism to leukotriene C(4). Leukotriene C4 239-252 cut like homeobox 1 Homo sapiens 0-3 11076395-5 2000 Prototypic endogenous substrates of high affinity for recombinant human MRP2 include bisglucuronosyl bilirubin, monoglucuronosyl bilirubin, and the glutathione S-conjugate leukotriene C4. Leukotriene C4 172-186 ATP binding cassette subfamily C member 2 Homo sapiens 72-76 10438957-8 1999 The neutralization of MCP-1 in allergic animals and instillation of MCP-1 in normal animals was related to leukotriene C4 levels in the bronchoalveolar lavage and was directly induced in pulmonary mast cells by MCP-1. Leukotriene C4 107-121 chemokine (C-C motif) ligand 2 Mus musculus 22-27 10556489-6 1999 The ATPase activity of reconstituted MRP1 was stimulated by the conjugated organic anion substrates leukotriene C(4) (LTC(4)) and 17beta-estradiol 17-(beta-D-glucuronide) with 50% maximal stimulation achieved at concentrations of 150 nM and 1.6 microM, respectively. Leukotriene C4 100-113 ATP binding cassette subfamily C member 1 Homo sapiens 37-41 10491184-5 1999 Isolated membrane vesicles from the MRP2-(His)6-expressing cells were active in ATP-dependent transport of the glutathione S-conjugate leukotriene C4 and were photoaffinity-labelled with 8-azido-[alpha-32P]ATP. Leukotriene C4 135-149 ATP binding cassette subfamily C member 2 Homo sapiens 36-40 10413292-5 1999 In some sub-classes of leukocytes, mrp contributes to the transport of leukotriene C4, an endogenous glutathione-S-conjugate. Leukotriene C4 71-85 ATP binding cassette subfamily C member 1 Homo sapiens 35-38 10438957-8 1999 The neutralization of MCP-1 in allergic animals and instillation of MCP-1 in normal animals was related to leukotriene C4 levels in the bronchoalveolar lavage and was directly induced in pulmonary mast cells by MCP-1. Leukotriene C4 107-121 chemokine (C-C motif) ligand 2 Mus musculus 68-73 10438957-8 1999 The neutralization of MCP-1 in allergic animals and instillation of MCP-1 in normal animals was related to leukotriene C4 levels in the bronchoalveolar lavage and was directly induced in pulmonary mast cells by MCP-1. Leukotriene C4 107-121 chemokine (C-C motif) ligand 2 Mus musculus 68-73 10456333-0 1999 Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). Leukotriene C4 44-58 ATP binding cassette subfamily C member 2 Homo sapiens 125-130 10438540-7 1999 For functional characterization of the Ycf1p variants, the kinetic parameters of glutathione S-conjugated leukotriene C(4) transport were measured. Leukotriene C4 106-119 ATP-binding cassette glutathione S-conjugate transporter YCF1 Saccharomyces cerevisiae S288C 39-44 10456333-0 1999 Enhanced transport of anticancer agents and leukotriene C4 by the human canalicular multispecific organic anion transporter (cMOAT/MRP2). Leukotriene C4 44-58 ATP binding cassette subfamily C member 2 Homo sapiens 131-135 10421658-7 1999 Leukotriene C(4) and 17beta-glucuronosyl estradiol, which are both known high-affinity substrates for human MRP2, inhibited [(3)H]MGB transport with IC(50) values of 2.3 and 30 micromol/L, respectively. Leukotriene C4 0-13 ATP binding cassette subfamily C member 2 Homo sapiens 108-112 10430730-7 1999 BALF levels of leukotriene C(4) (LTC(4)) showed a significant increase after eotaxin from 23.9 +/- 6.7 to 165.0 +/- 35.0 pg/ml (p < 0.05) but were partially suppressed by both SB210661 (71.2 +/- 21.0) and pranlukast (62.7 +/- 11.5). Leukotriene C4 15-28 chemokine (C-C motif) ligand 11 Mus musculus 77-84 10318872-9 1999 Analyses of the biological activities showed that hMBPH had effects similar to hMBP in cell killing and neutrophil (superoxide anion production and interleukin-8 release) and basophil (histamine and leukotriene C4 release) stimulation assays, but usually with reduced potency. Leukotriene C4 199-213 proteoglycan 3, pro eosinophil major basic protein 2 Homo sapiens 50-55 10652618-0 1999 Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. Leukotriene C4 83-97 ATP binding cassette subfamily C member 3 Homo sapiens 0-39 10652618-0 1999 Multidrug resistance-associated protein (MRP) mediated transport of daunomycin and leukotriene C4 (LTC4) in isolated plasma membrane vesicles. Leukotriene C4 83-97 ATP binding cassette subfamily C member 3 Homo sapiens 41-44 10393951-5 1999 Moreover, IL-4, which by itself had no visible effect on human MC, enhanced the release of histamine, leukotriene C4, and IL-5 in MC triggered by IgE receptor crosslinking. Leukotriene C4 102-116 interleukin 4 Homo sapiens 10-14 10384149-4 1999 Compared with control cultures, IL-5 increased the proportion of normal blood eosinophils immunostaining for FLAP (65 +/- 4 vs 34 +/- 4%; p < 0.0001), enhanced immunoblot levels of FLAP by 51 +/- 14% (p = 0.03), and quadrupled ionophore-stimulated leukotriene C4 synthesis from 5.7 to 20.8 ng/106 cells (p < 0.02). Leukotriene C4 251-265 interleukin 5 Homo sapiens 32-36 10318872-9 1999 Analyses of the biological activities showed that hMBPH had effects similar to hMBP in cell killing and neutrophil (superoxide anion production and interleukin-8 release) and basophil (histamine and leukotriene C4 release) stimulation assays, but usually with reduced potency. Leukotriene C4 199-213 myelin basic protein Homo sapiens 50-54 10198324-1 1999 Leukotriene C4 (LTC4), histamine, and other mediators can induce expression of P-selectin and platelet-activating factor (PAF) on venular endothelium to recruit leukocytes in vivo and in vitro via a juxtacrine mechanism of adhesion. Leukotriene C4 0-14 selectin, platelet Mus musculus 79-89 10385244-2 1999 The intracellular transport of leukotriene C4 (LTC4) in hematopoietic cells such as human monocytes is controlled by an ATP dependent carrier encoded by the multidrug resistance protein1 (MRPI) gene whose function can be blocked by the compound MK-571. Leukotriene C4 31-45 ATP binding cassette subfamily B member 1 Homo sapiens 157-186 10385244-2 1999 The intracellular transport of leukotriene C4 (LTC4) in hematopoietic cells such as human monocytes is controlled by an ATP dependent carrier encoded by the multidrug resistance protein1 (MRPI) gene whose function can be blocked by the compound MK-571. Leukotriene C4 31-45 ATP binding cassette subfamily B member 1 Homo sapiens 188-192 10220572-7 1999 The Km value of human MRP2 was 1.0 +/- 0.1 microM for leukotriene C4 and 7.2 +/- 0.7 microM for 17beta-glucuronosyl estradiol; the Km values of human MRP1 were 0.1 +/- 0.02 microM for leukotriene C4 and 1.5 +/- 0.3 microM for 17beta-glucoronosyl estradiol. Leukotriene C4 54-68 ATP binding cassette subfamily C member 2 Homo sapiens 22-26 10198324-1 1999 Leukotriene C4 (LTC4), histamine, and other mediators can induce expression of P-selectin and platelet-activating factor (PAF) on venular endothelium to recruit leukocytes in vivo and in vitro via a juxtacrine mechanism of adhesion. Leukotriene C4 0-14 patchy fur Mus musculus 94-120 10198324-1 1999 Leukotriene C4 (LTC4), histamine, and other mediators can induce expression of P-selectin and platelet-activating factor (PAF) on venular endothelium to recruit leukocytes in vivo and in vitro via a juxtacrine mechanism of adhesion. Leukotriene C4 0-14 patchy fur Mus musculus 122-125 10072549-10 1999 We found in this study that IgG or IL-5 also induces lipid body formation and subsequent leukotriene C4 production mediated by endogenous PAF. Leukotriene C4 89-103 interleukin 5 Homo sapiens 35-39 21781914-2 1999 Indomethacin (0.1 muM), which inhibits PGHS and significantly increases leukotriene C(4) production by enhancement of lipoxygenases, enhanced formation of OTA-DNA adducts tenfold. Leukotriene C4 72-88 latexin Homo sapiens 18-21 10201947-1 1999 Human basophils secrete histamine and leukotriene C4 (LTC4) in response to various stimuli, such as Ag and the bacterial product, FMLP. Leukotriene C4 38-52 formyl peptide receptor 1 Homo sapiens 130-134 10072549-10 1999 We found in this study that IgG or IL-5 also induces lipid body formation and subsequent leukotriene C4 production mediated by endogenous PAF. Leukotriene C4 89-103 PCNA clamp associated factor Homo sapiens 138-141 10470375-5 1999 The K(m) of leukotriene C4 for MRP2 is 10-fold higher than for MRP1, and the K(m) of 17 beta-glucuronosyl estradiol is 4.8-fold higher for MRP2 than for recombinant human MRP1. Leukotriene C4 12-26 ATP binding cassette subfamily C member 2 Homo sapiens 31-35 10064732-0 1999 Characterization of a leukotriene C4 export mechanism in human platelets: possible involvement of multidrug resistance-associated protein 1. Leukotriene C4 22-36 ATP binding cassette subfamily C member 1 Homo sapiens 98-139 9973428-0 1999 Decreased leukotriene C4 synthesis accompanies adherence-dependent nuclear import of 5-lipoxygenase in human blood eosinophils. Leukotriene C4 10-24 arachidonate 5-lipoxygenase Homo sapiens 85-99 9890956-3 1999 Here we report that leukotriene C4 is a potent inhibitor of MGST-1. Leukotriene C4 20-34 microsomal glutathione S-transferase 1 Homo sapiens 60-66 9890956-9 1999 Leukotriene C4 analogues, which have been developed as antagonists of leukotriene receptors, were found to display varying degrees of inhibition of MGST-1. Leukotriene C4 0-14 microsomal glutathione S-transferase 1 Homo sapiens 148-154 9890956-14 1999 Our discovery that leukotriene C4 and drugs developed based on its structure are potent inhibitors of MGST-1 raises the possibility that MGST-1 influences the cellular processing of leukotrienes. Leukotriene C4 19-33 microsomal glutathione S-transferase 1 Homo sapiens 102-108 9890956-14 1999 Our discovery that leukotriene C4 and drugs developed based on its structure are potent inhibitors of MGST-1 raises the possibility that MGST-1 influences the cellular processing of leukotrienes. Leukotriene C4 19-33 microsomal glutathione S-transferase 1 Homo sapiens 137-143 10077229-1 1999 Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG). Leukotriene C4 113-127 ATP binding cassette subfamily C member 3 Homo sapiens 0-39 10077229-1 1999 Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG). Leukotriene C4 113-127 ATP binding cassette subfamily C member 3 Homo sapiens 41-44 10077229-1 1999 Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG). Leukotriene C4 129-133 ATP binding cassette subfamily C member 3 Homo sapiens 0-39 10077229-1 1999 Multidrug resistance-associated protein (MRP) has been shown to transport glutathione (GSH) S-conjugates such as leukotriene C4 (LTC4) and S-(2,4-dinitrophenyl)-glutathione (DNP-SG). Leukotriene C4 129-133 ATP binding cassette subfamily C member 3 Homo sapiens 41-44 10470375-5 1999 The K(m) of leukotriene C4 for MRP2 is 10-fold higher than for MRP1, and the K(m) of 17 beta-glucuronosyl estradiol is 4.8-fold higher for MRP2 than for recombinant human MRP1. Leukotriene C4 12-26 ATP binding cassette subfamily C member 1 Homo sapiens 63-67 10470375-5 1999 The K(m) of leukotriene C4 for MRP2 is 10-fold higher than for MRP1, and the K(m) of 17 beta-glucuronosyl estradiol is 4.8-fold higher for MRP2 than for recombinant human MRP1. Leukotriene C4 12-26 ATP binding cassette subfamily C member 2 Homo sapiens 139-143 10470375-5 1999 The K(m) of leukotriene C4 for MRP2 is 10-fold higher than for MRP1, and the K(m) of 17 beta-glucuronosyl estradiol is 4.8-fold higher for MRP2 than for recombinant human MRP1. Leukotriene C4 12-26 ATP binding cassette subfamily C member 1 Homo sapiens 171-175 9987681-0 1999 Cytosolic phospholipase A2, increased and activated in the eosinophils of patients with hypereosinophilic syndrome in vivo, is involved in the augmented release of leukotriene C4. Leukotriene C4 164-178 phospholipase A2 group IVA Homo sapiens 0-26 10667333-3 1999 Reduction in 85 kDa PLA2 cellular protein levels by initiation site-directed antisense (SK 7111) or exposure to the 85 kDa PLA2 inhibitor, arachidonyl trifluormethyl ketone (AACOCF3), prevented A23187 or zymosan-stimulated monocytes prostanoid formation but not LTC4 or PAF production. Leukotriene C4 262-266 phospholipase A2 group IIA Homo sapiens 20-24 9822694-5 1998 Full-length MRP1 showed ATP-dependent, vanadate-sensitive accumulation of leukotriene C4 and N-ethylmaleimide glutathione. Leukotriene C4 74-88 ATP binding cassette subfamily C member 1 Canis lupus familiaris 12-16 9774450-1 1998 We have recently identified a mouse enzyme termed gamma-glutamyl leukotrienase (GGL) that converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). Leukotriene C4 99-113 gamma-glutamyltransferase 5 Mus musculus 50-78 9823323-5 1998 We have now established that the ATP/GSH dependent vincristine uptake is both proportional to the level of MRP in the membrane vesicles and can be inhibited by monoclonal antibodies shown previously to inhibit transport of established MRP substrates, such as leukotriene C4. Leukotriene C4 259-273 ATP binding cassette subfamily C member 1 Homo sapiens 235-238 9823323-8 1998 Although GSH or vincristine alone are very poor inhibitors of MRP-mediated transport of leukotriene C4, together they act as relatively potent competitive inhibitors. Leukotriene C4 88-102 ATP binding cassette subfamily C member 1 Homo sapiens 62-65 9823323-9 1998 Overall, our data demonstrate that MRP can actively cotransport GSH and unmodified vincristine and that these compounds probably interact, either with the leukotriene C4 binding site(s) on the protein or with a mutually exclusive site. Leukotriene C4 155-169 ATP binding cassette subfamily C member 1 Homo sapiens 35-38 9774450-1 1998 We have recently identified a mouse enzyme termed gamma-glutamyl leukotrienase (GGL) that converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). Leukotriene C4 99-113 gamma-glutamyltransferase 5 Mus musculus 80-83 9790952-1 1998 ONO-1078 is a new class of peptide leukotriene receptor antagonist, and multidrug resistance protein (MRP) is a membrane tranporter of multiple anticancer drugs and endogenous leukotriene C4 (LTC4). Leukotriene C4 176-190 ATP binding cassette subfamily C member 1 Homo sapiens 72-100 9790952-1 1998 ONO-1078 is a new class of peptide leukotriene receptor antagonist, and multidrug resistance protein (MRP) is a membrane tranporter of multiple anticancer drugs and endogenous leukotriene C4 (LTC4). Leukotriene C4 176-190 ATP binding cassette subfamily C member 1 Homo sapiens 102-105 9726996-2 1998 Purified MRP possesses ATPase activity which can be further stimulated by anticancer drugs or leukotriene C4. Leukotriene C4 94-108 ATP binding cassette subfamily C member 3 Homo sapiens 9-12 9632674-0 1998 Identification of glutathione as a driving force and leukotriene C4 as a substrate for oatp1, the hepatic sinusoidal organic solute transporter. Leukotriene C4 53-67 solute carrier organic anion transporter family member 4A1 L homeolog Xenopus laevis 87-92 9686618-6 1998 A newly synthesized lipid mediator, leukotriene C4, was also liberated from IL-3-primed, sIgA-stimulated basophils. Leukotriene C4 36-50 interleukin 3 Homo sapiens 76-80 9647783-0 1998 Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Leukotriene C4 104-118 ATP binding cassette subfamily C member 1 Homo sapiens 141-144 9647783-0 1998 Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Leukotriene C4 104-118 ATP binding cassette subfamily C member 1 Homo sapiens 145-149 9768595-0 1998 Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. Leukotriene C4 120-134 phospholipase A2 group IVA Homo sapiens 19-45 9768595-0 1998 Phosphorylation of cytosolic phospholipase A2 by IL-3 is associated with increased free arachidonic acid generation and leukotriene C4 release in human basophils. Leukotriene C4 120-134 interleukin 3 Homo sapiens 49-53 9768595-1 1998 BACKGROUND: Human basophils secrete leukotriene C4 (LTC4) in response to various stimuli, and a short treatment with IL-3 enhances LTC4 release, although IL-3 alone does not induce LTC4 release. Leukotriene C4 36-50 interleukin 3 Homo sapiens 117-121 9792445-0 1998 Human mast cells secreting leukotriene C4 express the MRP1 gene-encoded conjugate export pump. Leukotriene C4 27-41 ATP binding cassette subfamily C member 1 Homo sapiens 54-58 9632674-3 1998 The present study examined whether oatp1-mediated uptake is energized by efflux (countertransport) of intracellular reduced glutathione (GSH), and whether hydrophobic glutathione S-conjugates such as leukotriene C4 (LTC4) and S-dinitrophenyl glutathione (DNP-SG) form a novel class of substrates for oatp1. Leukotriene C4 200-214 solute carrier organic anion transporter family member 4A1 L homeolog Xenopus laevis 35-40 9632674-3 1998 The present study examined whether oatp1-mediated uptake is energized by efflux (countertransport) of intracellular reduced glutathione (GSH), and whether hydrophobic glutathione S-conjugates such as leukotriene C4 (LTC4) and S-dinitrophenyl glutathione (DNP-SG) form a novel class of substrates for oatp1. Leukotriene C4 216-220 solute carrier organic anion transporter family member 4A1 L homeolog Xenopus laevis 35-40 9530154-8 1998 The production of leukotriene C4 was inhibited by the phospholipase A2 (PLA2) inhibitor ONO-RS-082. Leukotriene C4 18-32 phospholipase A2 group IB Homo sapiens 54-70 9553138-5 1998 To begin to address this question, we examined the ability of various MRP fragments, expressed individually and in combination, to transport the MRP substrate, leukotriene C4 (LTC4). Leukotriene C4 160-174 ATP binding cassette subfamily C member 1 Homo sapiens 70-73 9553138-5 1998 To begin to address this question, we examined the ability of various MRP fragments, expressed individually and in combination, to transport the MRP substrate, leukotriene C4 (LTC4). Leukotriene C4 160-174 ATP binding cassette subfamily C member 1 Homo sapiens 145-148 9579392-2 1998 UTI attenuated the immunoglobulin E-mediated release of both preformed (histamine) and newly formed (leukotriene C4) mediators from RPMCs. Leukotriene C4 101-115 alpha-1-microglobulin/bikunin precursor Rattus norvegicus 0-3 9530154-8 1998 The production of leukotriene C4 was inhibited by the phospholipase A2 (PLA2) inhibitor ONO-RS-082. Leukotriene C4 18-32 phospholipase A2 group IB Homo sapiens 72-76 9393752-3 1997 Membrane vesicles prepared from ACNU-treated cells also displayed elevated transport activities for leukotriene C4, a known substrate for MRP. Leukotriene C4 100-114 ATP binding cassette subfamily C member 3 Homo sapiens 138-141 9430713-7 1998 Although the membrane vesicles from the control NIH/3T3 cells exhibited endogenous activity in transporting DNP-SG and leukotriene C4 in an ATP-dependent manner, the transfection of cMOAT cDNA resulted in a significant increase in the transport activity for these ligands. Leukotriene C4 119-133 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus 182-187 9465287-13 1998 AA and selective lipoxygenase products such as leukotriene C4 also participate in GnRH action, possibly by cross-talk with PKCs, or by an autocrine/paracrine amplification cycle. Leukotriene C4 47-61 gonadotropin releasing hormone 1 Homo sapiens 82-86 9442035-2 1998 The rates of production of leukotriene C4 (LTC4) and leukotriene B4 (LTB4) in cells that overexpressed PHGPx were 8 times lower than those in a control line of cells. Leukotriene C4 27-41 glutathione peroxidase 4 Rattus norvegicus 103-108 9460989-5 1998 With both CHO cell membrane preparations, we observed ATP-dependent transport of monoglutathionyl chlorambucil and of leukotriene C4, a glutathione S-conjugate and high-affinity substrate of MRP1. Leukotriene C4 118-132 ATP binding cassette subfamily C member 1 Homo sapiens 191-195 9875554-3 1998 Using mrp1-knockout mice, it has recently been shown that MRP1/mrp1 has an important role in the export of leukotriene C4 (LTC4), a mediator of inflammation, and in protecting the body from a number of toxins, including several antitumor drugs. Leukotriene C4 107-121 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 6-10 9875554-3 1998 Using mrp1-knockout mice, it has recently been shown that MRP1/mrp1 has an important role in the export of leukotriene C4 (LTC4), a mediator of inflammation, and in protecting the body from a number of toxins, including several antitumor drugs. Leukotriene C4 107-121 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 58-62 9875554-3 1998 Using mrp1-knockout mice, it has recently been shown that MRP1/mrp1 has an important role in the export of leukotriene C4 (LTC4), a mediator of inflammation, and in protecting the body from a number of toxins, including several antitumor drugs. Leukotriene C4 107-121 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 63-67 9378392-8 1997 Myeloperoxidase activity was increased in the first 24 hours, one week later mucosal nitric oxide synthase activity and generation of leukotriene B4, leukotriene C4 and thromboxane B2 were increased, whereas prostaglandin E2 generation was decreased notably. Leukotriene C4 150-164 myeloperoxidase Rattus norvegicus 0-15 9453467-4 1997 The potency (-log EC50 values) of SCA40 against spontaneous tone (6.52 +/- 0.10) was greater than against tone raised by equieffective concentrations (approximately 70%) of histamine (5.76 +/- 0.06), leukotriene C4 (5.44 +/- 0.11), and acetylcholine (4.98 +/- 0.09). Leukotriene C4 200-214 coiled-coil domain containing 88C Homo sapiens 34-39 9378992-5 1997 In this regard, the soluble receptor prevented IL-5-induced tyrosine phosphorylation of JAK2 kinase and IL-5R beta-chain and inhibited IL-5 priming of leukotriene C4 release by human basophils. Leukotriene C4 151-165 interleukin 5 Homo sapiens 47-51 9378992-5 1997 In this regard, the soluble receptor prevented IL-5-induced tyrosine phosphorylation of JAK2 kinase and IL-5R beta-chain and inhibited IL-5 priming of leukotriene C4 release by human basophils. Leukotriene C4 151-165 Janus kinase 2 Homo sapiens 88-92 9378992-5 1997 In this regard, the soluble receptor prevented IL-5-induced tyrosine phosphorylation of JAK2 kinase and IL-5R beta-chain and inhibited IL-5 priming of leukotriene C4 release by human basophils. Leukotriene C4 151-165 colony stimulating factor 2 receptor subunit beta Homo sapiens 104-114 9378992-5 1997 In this regard, the soluble receptor prevented IL-5-induced tyrosine phosphorylation of JAK2 kinase and IL-5R beta-chain and inhibited IL-5 priming of leukotriene C4 release by human basophils. Leukotriene C4 151-165 interleukin 5 Homo sapiens 104-108 8798642-10 1996 In zymosan-stimulated cells, there was significant diversion of metabolism to the 5-lipoxygenase products leukotriene C4 and 5-HETE and in A23187-treated cells to 5-HETE only. Leukotriene C4 106-120 arachidonate 5-lipoxygenase Mus musculus 82-96 19856299-1 1997 This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Leukotriene C4 72-85 interleukin 3 Homo sapiens 171-175 19856299-1 1997 This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Leukotriene C4 72-85 interleukin 5 Homo sapiens 177-181 19856299-1 1997 This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Leukotriene C4 72-85 interleukin 6 Homo sapiens 183-187 19856299-1 1997 This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Leukotriene C4 72-85 C-X-C motif chemokine ligand 8 Homo sapiens 189-193 19856299-1 1997 This study demonstrates the changing levels of leukotrieneB4 (LTB4) and leukotrieneC4 (LTC4) generated by human white blood cells primed with different human interleukins IL-3, IL-5, IL-6, IL-8 and with human hematopoietic growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Leukotriene C4 72-85 colony stimulating factor 2 Homo sapiens 287-293 9139674-0 1997 Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice. Leukotriene C4 14-28 gamma-glutamyltransferase 1 Mus musculus 32-61 9117095-14 1997 The alpha LTX-induced relaxation of LOS and OB muscle was associated with a 138% and 72% increase in cyclic GMP levels, respectively. Leukotriene C4 10-13 5'-nucleotidase, cytosolic II Homo sapiens 108-111 8977380-5 1997 In vitro exposure of purified hypothalamic astrocytes to TGF alpha or EGF in a defined medium led to activation of the cyclooxygenase-mediated pathway of arachidonic acid metabolism, as indicated by an increase in PGE2 release, but failed to affect lipooxygenase-mediated metabolism, as assessed by the lack of increase in leukotriene C4 production; addition of TGF alpha- (T-CM) or EGF-conditioned medium to cultures of LHRH-producing GT1-1 cells stimulated LHRH release. Leukotriene C4 323-337 transforming growth factor alpha Mus musculus 57-66 8973633-11 1996 These results indicate that the ATP-dependent release of leukotriene C4 by murine mastocytoma cells is mediated by murine Mrp. Leukotriene C4 57-71 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 122-125 8885844-5 1996 Drug uptake assays performed with membrane vesicles prepared from NIH3T3 cells transfected with a murine MRP expression vector revealed ATP-dependent transport for the natural product cytotoxic drugs daunorubicin and vincristine, as well as for the glutathione S-conjugates leukotriene C4 and azidophenacyl-S-glutathione. Leukotriene C4 274-288 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 105-108 8831715-10 1996 Several potential physiologic substrates of MRP including leukotriene C4 and 17 beta-estradiol-17-(beta-D-glucuronide) have been identified. Leukotriene C4 58-72 ATP binding cassette subfamily C member 1 Homo sapiens 44-47 9182688-4 1997 Eotaxin-2 induced chemotaxis of eosinophils as well as basophils, with a typically bimodal concentration dependence, and the release of histamine and leukotriene C4 from basophils that had been primed with IL-3. Leukotriene C4 150-164 C-C motif chemokine ligand 24 Homo sapiens 0-9 9182688-4 1997 Eotaxin-2 induced chemotaxis of eosinophils as well as basophils, with a typically bimodal concentration dependence, and the release of histamine and leukotriene C4 from basophils that had been primed with IL-3. Leukotriene C4 150-164 interleukin 3 Homo sapiens 206-210 9144509-0 1997 Leukotriene C4 secretion from normal murine mast cells by a probenecid-sensitive and multidrug resistance-associated protein-independent mechanism. Leukotriene C4 0-14 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 85-124 9130503-6 1997 Studies about the regulation of IgE-dependent and -independent IL-4/IL-13 expression by different cytokines, growth factors and chemokines demonstrate that the different basophil effector functions such as chemotaxis, exocytosis, leukotriene C4 formation and cytokine expression are regulated separately. Leukotriene C4 230-244 interleukin 4 Homo sapiens 63-67 9130503-6 1997 Studies about the regulation of IgE-dependent and -independent IL-4/IL-13 expression by different cytokines, growth factors and chemokines demonstrate that the different basophil effector functions such as chemotaxis, exocytosis, leukotriene C4 formation and cytokine expression are regulated separately. Leukotriene C4 230-244 interleukin 13 Homo sapiens 68-73 9099951-2 1997 Adhesion and spreading on fibronectin leads to increased degranulation, inositol phosphate production, phospholipase D activation, and increased production of prostaglandin D2 and leukotriene C4 when the cells are activated through the high affinity IgE receptor. Leukotriene C4 180-194 fibronectin 1 Rattus norvegicus 26-37 9045872-9 1997 Suppression of ELF by insulin (delta-reduction) was impaired in LTx-5 and LTx-13 when compared with CU and CON (P < 0.01), but normalized in LTx-26 (P < 0.004 vs. LTx-5 and P = 0.3 vs. CON). Leukotriene C4 64-67 insulin Homo sapiens 22-29 8955210-3 1996 In human basophils, NGF potentiates mediator release and primes the cells to produce leukotriene C4 in response to C5a. Leukotriene C4 85-99 nerve growth factor Homo sapiens 20-23 8855262-5 1996 Coligation of mAb B23.1 bound to gp49B1 and IgE fixed to the high-affinity Fc receptor for IgE on the surface of mouse bone marrow-derived mast cells inhibited exocytosis in a dose-related manner, as defined by the release of the secretory granule constituent beta-hexosaminidase, as well as the generation of the membrane-derived lipid mediator, leukotriene C4. Leukotriene C4 347-361 Fc receptor Mus musculus 75-86 8683259-1 1996 This study examined the effect of AA-861, a specific 5-lipoxygenase inhibitor, on brain levels of leukotriene C4 (LTC4) and correlated any changes with changes in edema formation and cerebral blood flow (CBF) after transient ischemia in gerbils. Leukotriene C4 98-112 arachidonate 5-lipoxygenase Homo sapiens 53-67 8702823-4 1996 By use of stable LLC-PK1 cell monolayers transfected with the rat OAT-K1 cDNA, the transporter was suggested to mediate basolateral uptake of methotrexate, an anionic anticancer drug, but not taurocholate, p-aminohippurate, prostaglandin E2, and leukotriene C4. Leukotriene C4 246-260 solute carrier organic anion transporter family member 1A3 Rattus norvegicus 66-72 8770059-0 1996 Leukotriene C4 inhibits ciliary activity in the presence of gamma-glutamyl transpeptidase. Leukotriene C4 0-14 inactive glutathione hydrolase 2 Homo sapiens 60-89 8806607-2 1996 The adenosine triphosphate(ATP)-dependent transport of leukotriene C4 (LTC4), an endogenous substrate for the glutathione S-conjugate export pump(GS-X pump), has been found in membrane vesicles prepared from KCP-4 cells. Leukotriene C4 55-69 ATP binding cassette subfamily C member 1 Homo sapiens 146-150 8663001-6 1996 The increased levels of MRP mRNA were closely related with enhanced activities of ATP-dependent transport of leukotriene C4 (LTC4) in plasma membrane vesicles. Leukotriene C4 109-123 ATP binding cassette subfamily C member 3 Homo sapiens 24-27 8630722-9 1996 CONCLUSION: Results indicated that oxatomide and ketotifen inhibit the production of leukotriene C4 and leukotriene B4 by inhibiting phospholipase A2 activity, whereas, azelastine inhibits the leukotriene C4 production by inhibiting phospholipase A2 and leukotriene C4 synthase. Leukotriene C4 85-99 phospholipase A2 group IB Rattus norvegicus 133-149 8938792-6 1996 P170 (MRP) synthesized in this system was capable of carrying out the ATP-dependent transport of leukotriene C4 into isolated membrane vesicles. Leukotriene C4 97-111 ATP binding cassette subfamily C member 3 Homo sapiens 6-9 8621643-0 1996 Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Leukotriene C4 57-71 ATP binding cassette subfamily C member 1 Homo sapiens 0-28 8621643-0 1996 Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles. Leukotriene C4 57-71 ATP binding cassette subfamily C member 1 Homo sapiens 30-33 8819279-6 1996 The comparative monitoring of systemic cytokine and cytokine antagonist levels, in particular the liberation of IL-1ra and IL-6 may provide useful parameters for the development of new liver preservation theories for LTx. Leukotriene C4 217-220 interleukin 1 receptor antagonist Homo sapiens 112-118 9863223-6 1996 ), an NK-2 receptor antagonist, partially inhibited LTC4-induced increase (46.6% and 37.5%, respectively) of dye extravasation from the atria of guinea pigs. Leukotriene C4 52-56 substance-K receptor Cavia porcellus 6-19 8819279-6 1996 The comparative monitoring of systemic cytokine and cytokine antagonist levels, in particular the liberation of IL-1ra and IL-6 may provide useful parameters for the development of new liver preservation theories for LTx. Leukotriene C4 217-220 interleukin 6 Homo sapiens 123-127 7667075-4 1995 Histamine (10 microM) and thrombin (10 U/ml) induced an abrupt and substantial decrease of TEER, bradykinin (1 microM) was less effective, PAF (380 nM) and LTC4 (1 microM) had no effect. Leukotriene C4 156-160 coagulation factor II, thrombin Homo sapiens 26-34 7595053-8 1995 In addition, the A23187-induced release of the inflammatory lipid mediator leukotriene C4 by CBEs was augmented by human amylin. Leukotriene C4 75-89 islet amyloid polypeptide Homo sapiens 121-127 7559771-7 1995 The transport function of the mrp gene-encoded conjugate export pump was assayed in plasma membrane vesicles with leukotriene C4 as a high-affinity glutathione S-conjugate substrate. Leukotriene C4 114-128 ATP binding cassette subfamily C member 2 Rattus norvegicus 30-33 7543541-9 1995 MBP also stimulated low levels of leukotriene C4 (LTC4) release from basophils of 84 to 99% purity, and experiments using enriched (18-63%) basophil preparations demonstrated that preincubation with IL-3, IL-5, and GM-CSF also potentiated MBP-stimulated leukotriene C4 release up to threefold in parallel with histamine release. Leukotriene C4 34-48 myelin basic protein Homo sapiens 0-3 7674234-13 1995 However, when purified leukotriene B4 or leukotriene C4 was added, there was an increase of 71 and 261%, respectively, in the stimulation of IL-3 production (p < 0/01). Leukotriene C4 41-55 interleukin 3 Mus musculus 141-145 7722326-10 1995 Furthermore, MBP and calcium ionophore ionomycin synergistically induced production of leukotriene C4 from eosinophils. Leukotriene C4 87-101 myelin basic protein Homo sapiens 13-16 7653666-6 1995 In addition, the effects of leukotriene C4, previously shown to stimulate Cl secretion via a neuronal pathway, were also inhibited by NPY. Leukotriene C4 28-42 neuropeptide Y Homo sapiens 134-137 7540649-0 1995 The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. Leukotriene C4 102-116 kit ligand Mus musculus 23-35 7540649-0 1995 The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. Leukotriene C4 102-116 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 168-194 7540649-0 1995 The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. Leukotriene C4 102-116 arachidonate 5-lipoxygenase Mus musculus 199-213 7530742-11 1995 Our results demonstrate that ET-1 can directly act as a histamine and serotonin secretagogue and as a stimulator of leukotriene C4 production in mast cells. Leukotriene C4 116-130 endothelin 1 Mus musculus 29-33 7536502-5 1995 Cross-linking of the high-affinity receptor for IgE (Fc epsilon RI) by a polyclonal anti-Fc epsilon antibody caused the release of preformed (histamine and tryptase) and de novo synthesized mediators [peptide leukotriene C4 (LTC4) and prostaglandin D2 (PGD2)]. Leukotriene C4 209-223 Fc epsilon receptor Ia Homo sapiens 53-66 7533185-12 1995 Cross-linking with anti-IgE of IgE on heart mast cells induced the release of tryptase (10.1 +/- 2.1 micrograms/10(7) cells; n = 10) and the de novo synthesis of PGD2 (17.3 +/- 4.3 ng/10(6) cells; n = 10) and of leukotriene C4 (19.1 +/- 4.5 ng/10(6) cells; n = 10). Leukotriene C4 212-226 prostaglandin D2 synthase Homo sapiens 162-166 7531878-0 1994 Polymorphonuclear leukocyte-platelet interaction: role of P-selectin in thromboxane B2 and leukotriene C4 cooperative synthesis. Leukotriene C4 91-105 selectin P Homo sapiens 58-68 7900879-1 1995 5-Lipoxygenase (5-LO) converts arachidonic acid, released from membrane phospholipids upon external stimulation, to leukotriene C4 (LTC4), which induces various kinds of cellular and molecular responses. Leukotriene C4 116-130 arachidonate 5-lipoxygenase Homo sapiens 0-14 7549524-0 1995 Effect of fibronectin on the production of leukotriene C4 by eosinophils. Leukotriene C4 43-57 fibronectin 1 Homo sapiens 10-21 7549524-1 1995 The effect of fibronectin on leukotriene C4 (LTC4) production by eosinophils was examined. Leukotriene C4 29-43 fibronectin 1 Homo sapiens 14-25 7818499-2 1994 MCII mast cells (a factor-dependent bone-marrow-derived murine mast cell line) produce significant amounts of leukotriene C4 (LTC4) (70 ng/10(6) cells) on cross-linking of Fc epsilon RI. Leukotriene C4 110-124 Fc receptor, IgE, high affinity I, gamma polypeptide Mus musculus 172-185 7961706-0 1994 The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates. Leukotriene C4 54-68 ATP binding cassette subfamily C member 3 Homo sapiens 4-7 7966417-4 1994 PURPOSE: In this study, we examined whether the active efflux pump for cisplatin in the cisplatin-resistant KB cells is the GS-X pump and tested its activity by using an endogenous substrate, [3H]leukotriene C4 ([3H]LTC4). Leukotriene C4 196-210 ATP binding cassette subfamily C member 1 Homo sapiens 124-128 8242237-13 1993 When PAF receptors were activated by PAF in the perfused heart, significant amounts of leukotriene C4 and leukotriene C4/D4/E4 were detected in the coronary effluent. Leukotriene C4 87-101 PCNA clamp associated factor Rattus norvegicus 5-8 8033515-6 1994 Blockade of cyclo-oxygenase with indomethacin or of lipoxygenase with ICI 207968 or of phospholipase A2 with mepacrine inhibited release of prostaglandin E2 or leukotriene C4 or both of these plus platelet-activating factor, respectively. Leukotriene C4 160-174 phospholipase A2 group IB Homo sapiens 87-103 7522171-0 1994 Endothelin-1 induces release of histamine and leukotriene C4 from mouse bone marrow-derived mast cells. Leukotriene C4 46-60 endothelin 1 Mus musculus 0-12 7522171-3 1994 Endothelin-1 at 1-100 nM concentration dependently induced release of histamine and immunoreactive leukotriene C4 from BMMC, while endothelin-3 at up to 100 nM did not stimulate the release of either mediator. Leukotriene C4 99-113 endothelin 1 Mus musculus 0-12 7522171-4 1994 Time course experiments revealed that the release of histamine and immunoreactive leukotriene C4 induced by endothelin-1 occurred rapidly, reaching near maximal levels within 20 s and 2 min, respectively, after the stimulation, while histamine release induced by antigen, at the concentration which induced an extent of release similar to that induced by 100 nM endothelin-1, required comparatively prolonged incubation (approximately 10 min for submaximal levels). Leukotriene C4 82-96 endothelin 1 Mus musculus 108-120 7522171-4 1994 Time course experiments revealed that the release of histamine and immunoreactive leukotriene C4 induced by endothelin-1 occurred rapidly, reaching near maximal levels within 20 s and 2 min, respectively, after the stimulation, while histamine release induced by antigen, at the concentration which induced an extent of release similar to that induced by 100 nM endothelin-1, required comparatively prolonged incubation (approximately 10 min for submaximal levels). Leukotriene C4 82-96 endothelin 1 Mus musculus 362-374 8242237-13 1993 When PAF receptors were activated by PAF in the perfused heart, significant amounts of leukotriene C4 and leukotriene C4/D4/E4 were detected in the coronary effluent. Leukotriene C4 87-101 PCNA clamp associated factor Rattus norvegicus 37-40 8436904-7 1993 IgER-induced IL-4 synthesis and release by basophils cultured with IL-3 was rapid and complete after 6 h. In contrast to IL-3, other cytokines (IL-5, granulocyte/macrophage colony-stimulating factor, and nerve growth factor) that also prime basophils for enhanced histamine and leukotriene C4 release did not promote IgER-induced IL-4 synthesis. Leukotriene C4 278-292 membrane spanning 4-domains A2 Homo sapiens 0-4 8223588-4 1993 The protein-kinase inhibitor K-252a and the selective PKC inhibitor CGP41251 completely blocked zymosan-triggered arachidonic acid release as well as prostaglandin E2 and leukotriene C4 synthesis. Leukotriene C4 171-185 protein kinase C, alpha Mus musculus 54-57 8214090-8 1993 Both contraction and muscarinic augmentation were blocked in 3-wk CDE after blockade of leukotriene C4 (LTC4) synthesis by pretreatment with the 5-lipoxygenase inhibitor, A63162 (50 microM). Leukotriene C4 88-102 arachidonate 5-lipoxygenase Homo sapiens 145-159 8097529-10 1993 These data implicate 5-lipoxygenase metabolite(s) (probably leukotriene C4) as a mediator for the IM-augmenting effect of SS. Leukotriene C4 60-74 arachidonate 5-lipoxygenase Homo sapiens 21-35 8415814-1 1993 Leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) are the 5-lipoxygenase and cyclooxygenase metabolites of arachidonic acid (AA). Leukotriene C4 0-14 arachidonate 5-lipoxygenase Rattus norvegicus 58-72 8415814-1 1993 Leukotriene C4 (LTC4) and prostaglandin E2 (PGE2) are the 5-lipoxygenase and cyclooxygenase metabolites of arachidonic acid (AA). Leukotriene C4 16-20 arachidonate 5-lipoxygenase Rattus norvegicus 58-72 8327407-0 1993 Differential effects of leukotriene C4 on endothelin-1 and prostacyclin release by cultured vascular cells. Leukotriene C4 24-38 endothelin 1 Homo sapiens 42-54 8327407-1 1993 Nanomolar concentrations of leukotriene C4 and phorbol 12-myristate acetate, a protein kinase C activator, stimulated endothelin-1 release by vascular endothelial but not smooth muscle cells. Leukotriene C4 28-42 endothelin 1 Homo sapiens 118-130 8436904-7 1993 IgER-induced IL-4 synthesis and release by basophils cultured with IL-3 was rapid and complete after 6 h. In contrast to IL-3, other cytokines (IL-5, granulocyte/macrophage colony-stimulating factor, and nerve growth factor) that also prime basophils for enhanced histamine and leukotriene C4 release did not promote IgER-induced IL-4 synthesis. Leukotriene C4 278-292 interleukin 3 Homo sapiens 67-71 8436904-7 1993 IgER-induced IL-4 synthesis and release by basophils cultured with IL-3 was rapid and complete after 6 h. In contrast to IL-3, other cytokines (IL-5, granulocyte/macrophage colony-stimulating factor, and nerve growth factor) that also prime basophils for enhanced histamine and leukotriene C4 release did not promote IgER-induced IL-4 synthesis. Leukotriene C4 278-292 interleukin 5 Homo sapiens 144-223 1314702-0 1992 Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production. Leukotriene C4 95-109 phospholipase A2 group IB Homo sapiens 54-70 8425605-1 1993 Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040 +/- 0.017 nmol LTC4 formed.min-1 x mg-1) and comparable to dimethylsulfoxide-differentiated U937 cells (0.399 +/- 0.084 nmol LTC4 formed.min-1 x mg-1). Leukotriene C4 118-122 leukotriene C4 synthase Homo sapiens 6-29 8425605-1 1993 Human leukotriene C4 synthase specific activity in the human monocytic leukemia cell line THP-1 (0.302 +/- 0.062 nmol LTC4 formed.min-1 x mg-1) was 7.6-fold higher than in U937 cells (0.040 +/- 0.017 nmol LTC4 formed.min-1 x mg-1) and comparable to dimethylsulfoxide-differentiated U937 cells (0.399 +/- 0.084 nmol LTC4 formed.min-1 x mg-1). Leukotriene C4 205-209 leukotriene C4 synthase Homo sapiens 6-29 1290416-1 1992 T-cell-derived lymphokine, IFN-gamma, has potent effects on B-cell differentiation and leukotriene C4 production in leukocytes, and inhibits the effect of IL-4 on IgE production. Leukotriene C4 87-101 interferon gamma Homo sapiens 27-36 8093353-1 1993 The enzyme gamma-glutamyl transferase (GGT) is a multifunctional enzyme that participates in a number of metabolic processes, including the conversion of leukotriene C4(LTC4) to leukotriene D4(LTD4). Leukotriene C4 154-168 gamma-glutamyltransferase 1 Homo sapiens 11-37 8093353-1 1993 The enzyme gamma-glutamyl transferase (GGT) is a multifunctional enzyme that participates in a number of metabolic processes, including the conversion of leukotriene C4(LTC4) to leukotriene D4(LTD4). Leukotriene C4 154-168 gamma-glutamyltransferase 1 Homo sapiens 39-42 1425916-3 1992 The fact that in mature human basophils the synthesis of leukotriene C4 (LTC4) induced by C5a is strictly dependent on a short preincubation with the cytokine interleukin-3 (IL-3), allowed us to investigate the metabolic requirements for LTC4 synthesis, and also to provide some information on early signal transduction mechanisms of IL-3 in these differentiated, non-dividing blood leukocytes. Leukotriene C4 57-71 complement C5a receptor 1 Homo sapiens 90-93 1425916-3 1992 The fact that in mature human basophils the synthesis of leukotriene C4 (LTC4) induced by C5a is strictly dependent on a short preincubation with the cytokine interleukin-3 (IL-3), allowed us to investigate the metabolic requirements for LTC4 synthesis, and also to provide some information on early signal transduction mechanisms of IL-3 in these differentiated, non-dividing blood leukocytes. Leukotriene C4 57-71 interleukin 3 Homo sapiens 159-172 1425916-3 1992 The fact that in mature human basophils the synthesis of leukotriene C4 (LTC4) induced by C5a is strictly dependent on a short preincubation with the cytokine interleukin-3 (IL-3), allowed us to investigate the metabolic requirements for LTC4 synthesis, and also to provide some information on early signal transduction mechanisms of IL-3 in these differentiated, non-dividing blood leukocytes. Leukotriene C4 57-71 interleukin 3 Homo sapiens 174-178 1425916-3 1992 The fact that in mature human basophils the synthesis of leukotriene C4 (LTC4) induced by C5a is strictly dependent on a short preincubation with the cytokine interleukin-3 (IL-3), allowed us to investigate the metabolic requirements for LTC4 synthesis, and also to provide some information on early signal transduction mechanisms of IL-3 in these differentiated, non-dividing blood leukocytes. Leukotriene C4 57-71 interleukin 3 Homo sapiens 334-338 1517222-2 1992 The specific activity of LTC4 synthase in differentiated cells (399.0 +/- 84.1 pmol of LTC4 formed.min-1.mg-1) was markedly higher (10-fold; p less than 0.001) than in undifferentiated U937 cells (39.9 +/- 16.7 pmol of LTC4 formed.min-1.mg-1) or freshly isolated blood monocytes (21.5 +/- 4.8 pmol of LTC4 formed.min-1.mg-1). Leukotriene C4 87-91 leukotriene C4 synthase Homo sapiens 25-38 1517222-2 1992 The specific activity of LTC4 synthase in differentiated cells (399.0 +/- 84.1 pmol of LTC4 formed.min-1.mg-1) was markedly higher (10-fold; p less than 0.001) than in undifferentiated U937 cells (39.9 +/- 16.7 pmol of LTC4 formed.min-1.mg-1) or freshly isolated blood monocytes (21.5 +/- 4.8 pmol of LTC4 formed.min-1.mg-1). Leukotriene C4 87-91 leukotriene C4 synthase Homo sapiens 25-38 1569397-6 1992 Furthermore, MCP-1 promotes the formation of leukotriene C4 by basophils pretreated with interleukin 3 (IL-3), IL-5, or granulocyte/macrophage colony-stimulating factor. Leukotriene C4 45-59 C-C motif chemokine ligand 2 Homo sapiens 13-18 1569397-6 1992 Furthermore, MCP-1 promotes the formation of leukotriene C4 by basophils pretreated with interleukin 3 (IL-3), IL-5, or granulocyte/macrophage colony-stimulating factor. Leukotriene C4 45-59 interleukin 3 Homo sapiens 89-108 1569397-6 1992 Furthermore, MCP-1 promotes the formation of leukotriene C4 by basophils pretreated with interleukin 3 (IL-3), IL-5, or granulocyte/macrophage colony-stimulating factor. Leukotriene C4 45-59 interleukin 5 Homo sapiens 111-115 1314702-4 1992 We conclude that PLA2/5-lipoxygenase-mediated leukotriene C4 production constitutes a novel and specific signal transduction pathway in growth factor action. Leukotriene C4 46-60 phospholipase A2 group IIA Homo sapiens 17-21 1314702-4 1992 We conclude that PLA2/5-lipoxygenase-mediated leukotriene C4 production constitutes a novel and specific signal transduction pathway in growth factor action. Leukotriene C4 46-60 arachidonate 5-lipoxygenase Homo sapiens 22-36 1314702-0 1992 Epidermal growth factor activates calcium channels by phospholipase A2/5-lipoxygenase-mediated leukotriene C4 production. Leukotriene C4 95-109 arachidonate 5-lipoxygenase Homo sapiens 71-85 1551409-0 1992 Opposing effects of tumor necrosis factor-alpha and nerve growth factor upon leukotriene C4 production by human eosinophils triggered with N-formyl-methionyl-leucyl-phenylalanine. Leukotriene C4 77-91 tumor necrosis factor Homo sapiens 20-47 1373172-2 1992 The nonselective PDE inhibitors, theophylline and 3-isobutyl-1-methylxanthine, inhibited anti-IgE-induced release of histamine and leukotriene C4 (LTC4) from basophils. Leukotriene C4 131-145 immunoglobulin heavy constant epsilon Homo sapiens 94-97 1533539-4 1992 In a basophil mediator release assay, three peptides inhibited the priming effect of interleukin (IL)-3, IL-5, and granulocyte/macrophage colony-stimulating factor (GM-CSF) on synthesis of leukotriene C4 induced by chemotactic peptides. Leukotriene C4 189-203 interleukin 3 Homo sapiens 85-103 1387538-9 1992 Leukotriene C and prostaglandin E2 were found to be specific noncompetitive inhibitors of the rat galactosyltransferase-associated kinase. Leukotriene C4 0-13 glycoprotein alpha-galactosyltransferase 1 Rattus norvegicus 98-119 1550768-4 1992 GM-CSF and IL-3 enhanced the generation of leukotriene C4 (LTC4) induced by calcium ionophore A23187 and the release of arylsulphatase and beta-glucuronidase from specific and small granules of eosinophils. Leukotriene C4 43-57 colony stimulating factor 2 Homo sapiens 0-6 1550768-4 1992 GM-CSF and IL-3 enhanced the generation of leukotriene C4 (LTC4) induced by calcium ionophore A23187 and the release of arylsulphatase and beta-glucuronidase from specific and small granules of eosinophils. Leukotriene C4 43-57 interleukin 3 Homo sapiens 11-15 1533539-4 1992 In a basophil mediator release assay, three peptides inhibited the priming effect of interleukin (IL)-3, IL-5, and granulocyte/macrophage colony-stimulating factor (GM-CSF) on synthesis of leukotriene C4 induced by chemotactic peptides. Leukotriene C4 189-203 colony stimulating factor 2 Homo sapiens 115-163 1533539-4 1992 In a basophil mediator release assay, three peptides inhibited the priming effect of interleukin (IL)-3, IL-5, and granulocyte/macrophage colony-stimulating factor (GM-CSF) on synthesis of leukotriene C4 induced by chemotactic peptides. Leukotriene C4 189-203 colony stimulating factor 2 Homo sapiens 165-171 1835466-1 1991 Lysophosphatidylcholine (lyso-PC), a natural product of phospholipase A2 activity, induced the secretion of both granule-associated beta-hexosaminidase and newly generated leukotriene C4 from mouse bone marrow-derived mast cells. Leukotriene C4 172-186 phospholipase A2, group IB, pancreas Mus musculus 56-72 1370529-4 1992 Here, we show that the c-kit ligand (KL), a recently identified stem cell growth factor, at concentrations 10-100 times lower than that required to promote cell proliferation, enhances the release of histamine and leukotriene C4 in response to IgE receptor crosslinking of human lung MC. Leukotriene C4 214-228 KIT ligand Homo sapiens 23-35 1370529-4 1992 Here, we show that the c-kit ligand (KL), a recently identified stem cell growth factor, at concentrations 10-100 times lower than that required to promote cell proliferation, enhances the release of histamine and leukotriene C4 in response to IgE receptor crosslinking of human lung MC. Leukotriene C4 214-228 KIT ligand Homo sapiens 37-39 1721644-5 1991 FK-506 also inhibited the de novo synthesis of 5-lipoxygenase (sulfidopeptide leukotriene C4) and cyclo-oxygenase (prostaglandin D2) metabolites of arachidonic acid from mast cells challenged with anti-IgE. Leukotriene C4 78-92 arachidonate 5-lipoxygenase Homo sapiens 47-61 1940371-0 1991 IL-3 and IL-5 prime normal human eosinophils to produce leukotriene C4 in response to soluble agonists. Leukotriene C4 56-70 interleukin 3 Homo sapiens 0-4 1940371-0 1991 IL-3 and IL-5 prime normal human eosinophils to produce leukotriene C4 in response to soluble agonists. Leukotriene C4 56-70 interleukin 5 Homo sapiens 9-13 1993484-11 1991 On the other hand, certain protective compounds exhibit a striking parallelism between protection and inhibition of ethanol-induced leukotriene C4 formation, suggesting that they may affect a target crucial for both mucosal injury and stimulation of 5-lipoxygenase. Leukotriene C4 132-146 arachidonate 5-lipoxygenase Rattus norvegicus 250-264 1645746-0 1991 Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP. Leukotriene C4 140-154 colony stimulating factor 2 Homo sapiens 62-110 1645746-0 1991 Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP. Leukotriene C4 140-154 formyl peptide receptor 1 Homo sapiens 170-174 1871376-6 1991 Exogenous prostaglandin E2 and leukotriene C4 both stimulated, the release of luteinizing hormone-releasing hormone to the same extent from both the adult and immature median eminences. Leukotriene C4 31-45 gonadotropin releasing hormone 1 Rattus norvegicus 78-115 1676842-8 1991 Our results indicate that GGT can no longer be considered the only enzyme capable of cleaving the gamma-glutamyl linkage of leukotriene C4 and, most likely, of other natural compounds. Leukotriene C4 124-138 inactive glutathione hydrolase 2 Homo sapiens 26-29 1650873-1 1991 Leukotriene C4 (LTC4), one of the major constituents of the slow reacting substance of anaphylaxis, induced a dose-dependent hydrolysis of phosphoinositides in [3H]inositol-prelabeled rat basophilic leukemia (RBL-1) cells. Leukotriene C4 0-14 RB transcriptional corepressor like 1 Rattus norvegicus 209-214 1847165-9 1991 It is likely that the activation of murine eosinophils by a Fc-gamma R mechanism stimulates phosphoinositide breakdown as a primary step that leads to the activation of murine 5"-lipoxygenase, producing the formation of leukotriene C4. Leukotriene C4 220-234 arachidonate 5-lipoxygenase Mus musculus 176-191 1825502-2 1991 Exposure of mouse peritoneal macrophages to particulate beta 1,3-glucan (100 micrograms/ml) was also found to stimulate the production of eicosanoids from both the cyclooxygenase (prostaglandin E2) and 5"-lipoxygenase (leukotriene C4) pathways. Leukotriene C4 219-233 hemoglobin, beta adult major chain Mus musculus 56-64 1705512-2 1991 Furthermore, basophils exposed to IL 3 generate large amounts of leukotriene C4 in response to C5a, a basophil agonist which by itself is unable to promote lipid mediator formation. Leukotriene C4 65-79 interleukin 3 Homo sapiens 34-38 1705512-2 1991 Furthermore, basophils exposed to IL 3 generate large amounts of leukotriene C4 in response to C5a, a basophil agonist which by itself is unable to promote lipid mediator formation. Leukotriene C4 65-79 complement C5a receptor 1 Homo sapiens 95-98 1650873-1 1991 Leukotriene C4 (LTC4), one of the major constituents of the slow reacting substance of anaphylaxis, induced a dose-dependent hydrolysis of phosphoinositides in [3H]inositol-prelabeled rat basophilic leukemia (RBL-1) cells. Leukotriene C4 16-20 RB transcriptional corepressor like 1 Rattus norvegicus 209-214 1701820-3 1990 However, at low concentrations (0.1-10 ng/ml), IL-5 rapidly primes basophils for enhanced histamine release and leukotriene C4 (LTC4) generation in response to all established basophil agonists. Leukotriene C4 112-126 interleukin 5 Homo sapiens 47-51 1692857-8 1990 Maximum anti-IgE challenge of nearly homogeneous formalin-sensitive mast cells (94.3 +/- 2.1% purity, n = 6) caused the generation of both leukotriene C4 (64.6 +/- 26.4 pg/mast cell) and PGD2 (114.8 +/- 37.5 pg/mast cell). Leukotriene C4 139-153 prostaglandin D2 synthase Homo sapiens 187-191 1697311-6 1990 The PF HRF not only degranulated MBMMC, but also induced the generation of the arachidonic acid metabolite leukotriene C4 from MBMMC (24.6 +/- 4.2 ng leukotriene C4/10(6) MBMMC). Leukotriene C4 107-121 tumor protein, translationally-controlled 1 Homo sapiens 7-10 1697311-6 1990 The PF HRF not only degranulated MBMMC, but also induced the generation of the arachidonic acid metabolite leukotriene C4 from MBMMC (24.6 +/- 4.2 ng leukotriene C4/10(6) MBMMC). Leukotriene C4 150-164 tumor protein, translationally-controlled 1 Homo sapiens 7-10 1979846-6 1990 The concentration of leukotriene C4 in brain tissue increased significantly during reperfusion: treatment with a 5-lipoxygenase inhibitor, AA-861, decreased the increase of brain water content associated with reperfusion. Leukotriene C4 21-35 arachidonate 5-lipoxygenase Rattus norvegicus 113-127 1974033-7 1990 We find that the IM-augmenting effects of somatostatin are abolished by two substances that can inhibit phospholipase A2, quinacrine and 4-bromophenacyl bromide, and that both arachidonic acid and leukotriene C4 mimic the effects of somatostatin-14 on hippocampal pyramidal neurons in vitro. Leukotriene C4 197-211 somatostatin Homo sapiens 42-54 2112758-0 1990 Leukotriene C4 is an essential 5-lipoxygenase intermediate in A23187-induced macrophage cytostatic activity against P815 tumor cells. Leukotriene C4 0-14 arachidonate 5-lipoxygenase Mus musculus 31-45 1966812-5 1990 Interleukin-3 (IL-3), another hematopoetic growth factor, enhances granule release and more profoundly leukotriene C4 (LTC4) synthesis in basophils stimulated by immunoglobulin-E (IgE)-dependent or -independent agonists. Leukotriene C4 103-117 interleukin 3 Homo sapiens 0-13 2106525-5 1990 Conversely, leukotriene C4, a distal metabolite in the arachidonic acid 5-lipoxygenase pathway, increased the hydroxylation reaction by 234% and restored dexamethasone-inhibited PAM 1,25-(OH)2D3 synthetic activity. Leukotriene C4 12-26 arachidonate 5-lipoxygenase Homo sapiens 55-86 2212547-5 1990 A selective 5-lipoxygenase inhibitor, AA-861, inhibited the gastric lesion, and immunoreactive leukotriene C4 (LTC4) was detected in the gastric wall. Leukotriene C4 95-109 arachidonate 5-lipoxygenase Rattus norvegicus 12-26 1966812-5 1990 Interleukin-3 (IL-3), another hematopoetic growth factor, enhances granule release and more profoundly leukotriene C4 (LTC4) synthesis in basophils stimulated by immunoglobulin-E (IgE)-dependent or -independent agonists. Leukotriene C4 103-117 interleukin 3 Homo sapiens 15-19 2106713-3 1990 The LHRH released by the median eminence (ME) of castrated rats in the presence of PGE2 (10(-6) M), LTC4 (10(-8) M), norepinephrine (NE) (10(-5) M) or dopamine (DA) (10(-5) M and 10(-4) M) was significantly lower than the LHRH released by intact animals in the presence of these factors. Leukotriene C4 100-104 gonadotropin releasing hormone 1 Rattus norvegicus 4-8 2194089-0 1990 Leukotriene C4-induced release of LHRH into the hypophyseal portal blood and of LH into the peripheral blood. Leukotriene C4 0-14 gonadotropin releasing hormone 1 Rattus norvegicus 34-38 34968576-0 2022 Leukotriene C4 synthase is a novel PPARgamma target gene, and leukotriene C4 and D4 activate adipogenesis through cysteinyl LT1 receptors in adipocytes. Leukotriene C4 62-76 lurcher transcript 1 Mus musculus 124-127 2341334-3 1990 Pretreatment of the lungs with a noninjurious dose of PAF (1.6 nM) 10 min before protamine markedly potentiated protamine-induced pulmonary vasoconstriction and resulted in severe lung edema and increased lung tissue content of 6-keto-prostaglandin F1 alpha, thromboxane B2, and leukotriene C4. Leukotriene C4 279-293 PCNA clamp associated factor Rattus norvegicus 54-57 34768857-1 2021 The mammalian exclusive Orai3 channel participates in the generation and/or modulation of two independent Ca2+ currents, the store-operated current, Icrac, involving functional interactions between the stromal interaction molecules (STIM), STIM1/STIM2, and Orai1/Orai2/Orai3, as well as the store-independent arachidonic acid (AA) (or leukotriene C4)-regulated current Iarc, which involves Orai1, Orai3 and STIM1. Leukotriene C4 335-349 ORAI calcium release-activated calcium modulator 3 Homo sapiens 24-29 34572251-12 2021 CONCLUSION: Early diagnosis of NPC continues to be a challenge and a definitive diagnosis is often made only after LTx. Leukotriene C4 115-118 NPC intracellular cholesterol transporter 1 Homo sapiens 31-34 34193360-7 2021 EVLP promoted significant inflammation in both cold (CI-E) and warm (WI-E) groups, which was not associated with cell death or DAMP release at the end of EVLP, but with the release of S100A8 after LTx. Leukotriene C4 197-200 S100 calcium binding protein A8 Rattus norvegicus 184-190 34193360-10 2021 The release of HMGB1 (in the absence of EVLP) and S100A8 (following EVLP) may be important factors in the pathogenesis of LTx. Leukotriene C4 122-125 high mobility group box 1 Rattus norvegicus 15-20 34193360-10 2021 The release of HMGB1 (in the absence of EVLP) and S100A8 (following EVLP) may be important factors in the pathogenesis of LTx. Leukotriene C4 122-125 S100 calcium binding protein A8 Rattus norvegicus 50-56 35592105-6 2022 Predictors for negative response in the recipients were interleukin-2 receptor (IL-2R) induction during LTx, shorter time post LTx and application of a derivative from mycophenolate acid (MPA). Leukotriene C4 104-107 interleukin 2 receptor subunit alpha Homo sapiens 56-78 34629389-4 2022 Here, we show that transmembrane protein 184B (TMEM184B), a protein with roles in axon degeneration and nerve terminal maintenance, is required for the expression of a large cohort of itch receptors, including those for interleukin 31 (IL-31), leukotriene C4, and histamine. Leukotriene C4 244-258 transmembrane protein 184b Mus musculus 19-45 34629389-4 2022 Here, we show that transmembrane protein 184B (TMEM184B), a protein with roles in axon degeneration and nerve terminal maintenance, is required for the expression of a large cohort of itch receptors, including those for interleukin 31 (IL-31), leukotriene C4, and histamine. Leukotriene C4 244-258 transmembrane protein 184b Mus musculus 47-55 34291152-12 2021 Patients who developed RAS had higher mean COMP levels between 1 and 3 mo after LTx than those who did not develop RAS (10.9 (3.9-17.5) U/L vs 7.4 (3.9-10.8) U/L, P = 0.008). Leukotriene C4 80-83 cartilage oligomeric matrix protein Homo sapiens 43-47 34199119-8 2021 Leukotriene C4 (LTC4), is a high-affinity substrate of ABCC1. Leukotriene C4 0-14 ATP binding cassette subfamily C member 1 Bos taurus 55-60 35592105-6 2022 Predictors for negative response in the recipients were interleukin-2 receptor (IL-2R) induction during LTx, shorter time post LTx and application of a derivative from mycophenolate acid (MPA). Leukotriene C4 104-107 interleukin 2 receptor subunit alpha Homo sapiens 80-85 35126696-9 2022 In addition, the expression levels of ovalbumin (OVA)-specific immunoglobulin E (IgE), leukotriene C4 (LTC4) and certain inflammatory factors were assessed by ELISA. Leukotriene C4 87-101 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 38-47 35181243-11 2022 CONCLUSIONS: Our data suggest that an early increase of CD4+CD57+ILT2+ T cells after LTx may be associated with CLAD onset. Leukotriene C4 85-88 CD4 molecule Homo sapiens 56-59 35181243-11 2022 CONCLUSIONS: Our data suggest that an early increase of CD4+CD57+ILT2+ T cells after LTx may be associated with CLAD onset. Leukotriene C4 85-88 beta-1,3-glucuronyltransferase 1 Homo sapiens 60-64 35181243-11 2022 CONCLUSIONS: Our data suggest that an early increase of CD4+CD57+ILT2+ T cells after LTx may be associated with CLAD onset. Leukotriene C4 85-88 leukocyte immunoglobulin like receptor B1 Homo sapiens 65-69 35126696-9 2022 In addition, the expression levels of ovalbumin (OVA)-specific immunoglobulin E (IgE), leukotriene C4 (LTC4) and certain inflammatory factors were assessed by ELISA. Leukotriene C4 87-101 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 49-52 2527196-4 1989 Release of the pre-formed granule constituents, RMCPII and beta-hex, was associated with the generation of the membrane-derived lipid mediator, leukotriene C4 (LTC4) and, in older cultures, substantial amounts were generated (25.2 ng/10(6) BMMC). Leukotriene C4 144-158 O-GlcNAcase Rattus norvegicus 59-67 2572437-5 1989 Sulfasalazine inhibited the synthesis of 5-lipoxygenase products (5-hydroxyeicosatetraenoic acid and leukotriene B4: IC50 250 microM, leukotriene C4: IC50 100 microM) in a concentration-dependent manner but had no effect on 15-hydroxyeicosatetraenoic acid formation. Leukotriene C4 134-148 arachidonate 5-lipoxygenase Homo sapiens 41-55 2474353-4 1989 Challenge of gradient fractions with epsilon-chain-specific anti-human IgE stimulated the release of histamine, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4). Leukotriene C4 140-154 immunoglobulin heavy constant epsilon Homo sapiens 71-74 35011703-8 2022 We found that hEOS biosynthesized leukotriene (LT) C4 and LTB4 in a 5:1 ratio while mEOS almost exclusively biosynthesized LTB4. Leukotriene C4 34-53 EOS Homo sapiens 14-18 2510565-0 1989 Identification of an alveolar macrophage-derived activity in bronchial asthma that enhances leukotriene C4 generation by human eosinophils stimulated by ionophore A23187 as a granulocyte-macrophage colony-stimulating factor. Leukotriene C4 92-106 colony stimulating factor 2 Homo sapiens 175-223 3126256-7 1988 A23187 greatly increased the amount of lipoxygenase products secreted from LPS-primed macrophages, leukotriene C4 synthesis being increased 150-fold. Leukotriene C4 99-113 interferon regulatory factor 6 Homo sapiens 75-78 3145470-3 1988 Leukotriene C4 also enhanced prolactin release that was induced by phorbol myristate acetate (a protein kinase C activator) by maitotoxin (a calcium uptake stimulator), and by angiotensin II. Leukotriene C4 0-14 angiotensinogen Rattus norvegicus 176-190 3133397-7 1988 Eosinophils exposed to 1,000 pM IL-3 for 30 min or cultured in 10 pM IL-3 for 7 d generated approximately threefold more leukotriene C4 (LTC4) in response to calcium ionophore than freshly isolated cells. Leukotriene C4 121-135 interleukin 3 Homo sapiens 32-36 3133397-7 1988 Eosinophils exposed to 1,000 pM IL-3 for 30 min or cultured in 10 pM IL-3 for 7 d generated approximately threefold more leukotriene C4 (LTC4) in response to calcium ionophore than freshly isolated cells. Leukotriene C4 121-135 interleukin 3 Homo sapiens 69-73 3354024-6 1988 That the increased brain water content was causally related to an increase in leukotriene C4 was supported by results obtained following administration of the 5-lipoxygenase inhibitors ONO-LP-016 and AA-861. Leukotriene C4 78-92 arachidonate 5-lipoxygenase Rattus norvegicus 159-173 3147587-2 1988 PAF has been shown to be a chemotactic factor for eosinophils, which conversely release leukotriene C4 on activation. Leukotriene C4 88-102 PCNA clamp associated factor Homo sapiens 0-3 3137306-3 1988 The results indicate that enhanced production of leukotriene C4 is a common feature of murine autoimmunity and suggest further that aberrations in 5-lipoxygenase activity may play a role in the development of lupus. Leukotriene C4 49-63 arachidonate 5-lipoxygenase Mus musculus 147-161 3390866-3 1988 Synthesis of leukotriene C4 (LTC4) is dependent on glutathione S-transferase (GST). Leukotriene C4 13-27 glutathione S-transferase kappa 1 Homo sapiens 51-76 3390866-3 1988 Synthesis of leukotriene C4 (LTC4) is dependent on glutathione S-transferase (GST). Leukotriene C4 13-27 glutathione S-transferase kappa 1 Homo sapiens 78-81 2454033-2 1988 LTC4 given intravenously in various doses ranging from 0.35 to 2.8 nmol.kg-1.h-1 in conscious dogs caused a dose-dependent inhibition of pancreatic HCO-3 and protein responses to exogenous hormones such as secretin, cholecystokinin octapeptide (CCK-8), and bombesin and to endogenous stimulants including meat feeding and duodenal perfusion with oleate. Leukotriene C4 0-4 cholecystokinin Canis lupus familiaris 245-248 2451645-5 1988 The enhanced release of histamine and LTC4 from basophils challenged with allergen was suppressed by Dimaprit, a histamine H2 receptor agonist, at a concentration required to inhibit the release by 50% of 5 X 10(-5) M for histamine and 10(-5) M for LTC4. Leukotriene C4 38-42 histamine receptor H2 Homo sapiens 113-134 2451645-5 1988 The enhanced release of histamine and LTC4 from basophils challenged with allergen was suppressed by Dimaprit, a histamine H2 receptor agonist, at a concentration required to inhibit the release by 50% of 5 X 10(-5) M for histamine and 10(-5) M for LTC4. Leukotriene C4 249-253 histamine receptor H2 Homo sapiens 113-134 2453912-2 1988 CsA (3 X 10(-2) to 1 microgram/ml) dose-dependently inhibited IgE-mediated release of histamine and peptide leukotriene C4 (LTC4) from human lung mast cells. Leukotriene C4 108-122 ERCC excision repair 8, CSA ubiquitin ligase complex subunit Homo sapiens 0-3 2826530-10 1988 Maximal binding occurred at 5 min of incubation at 22 or 38 C. The presence of serine borate, a gamma-glutamyl transpeptidase inhibitor, in the incubation medium resulted in a small to moderate increase in leukotriene C4 binding to uterine cells. Leukotriene C4 206-220 inactive glutathione hydrolase 2 Homo sapiens 96-125 2453912-2 1988 CsA (3 X 10(-2) to 1 microgram/ml) dose-dependently inhibited IgE-mediated release of histamine and peptide leukotriene C4 (LTC4) from human lung mast cells. Leukotriene C4 108-122 immunoglobulin heavy constant epsilon Homo sapiens 62-65 3121320-12 1987 These results suggest that mainly GST-Yn1 Yn1 may be involved in leukotriene-C4 synthesis in rat brain. Leukotriene C4 65-79 hematopoietic prostaglandin D synthase Rattus norvegicus 34-37 3120489-7 1987 Moreover, cisternal CSF level of prostaglandin D2 and leukotriene C4 are significantly higher in patients with symptomatic vasospasm. Leukotriene C4 54-68 colony stimulating factor 2 Homo sapiens 20-23 3118415-4 1987 These results show that PAF is capable of inducing and enhancing the leukotriene C4 formation by human eosinophils. Leukotriene C4 69-83 PCNA clamp associated factor Homo sapiens 24-27