PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26993165-1	2016	Previous studies indicated that maturation inducing hormone, 17alpha, 20beta-Dihydroxy-4-pregnen-3-one (DHP), probably through nuclear progestin receptor (Pgr), might be involved in spermatogenesis and oogenesis in fish.	dhp	104-107	progesterone receptor	Oreochromis niloticus	155-158
26993165-9	2016	Taken together, our data further proved that DHP, possibly through Pgr, might be essential in the ovarian differentiation and estrogen production in fish.	dhp	45-48	progesterone receptor	Oreochromis niloticus	67-70
23925891-9	2014	hCG, like DHP, is equally potent and induces oocyte maturation via DHP production in vitro.	dhp	10-13	hypertrichosis 2 (generalised, congenital)	Homo sapiens	0-3
25944019-0	2015	Adherence to Metformin, Statins, and ACE/ARBs Within the Diabetes Health Plan (DHP).	dhp	79-82	angiotensin I converting enzyme	Homo sapiens	37-40
25944019-12	2015	In the first year after DHP implementation, predicted employer-level adherence for metformin (+4.9 percentage points, p = 0.017), statins (+4.8, p = 0.019), and ACE/ARBs (+4.4, p = 0.02) was higher with DHP purchase.	dhp	24-27	angiotensin I converting enzyme	Homo sapiens	161-164
26001539-0	2015	Capsule Commentary on Duru et al., Adherence to Metformin, Statins, and ACE/ARBs Within the Diabetes Health Plan (DHP).	dhp	114-117	angiotensin I converting enzyme	Homo sapiens	72-75
26664375-0	2015	Design, Synthesis and Biological Evaluation of New 1, 4-Dihydropyridine (DHP) Derivatives as Selective Cyclooxygenase-2 Inhibitors.	dhp	73-76	prostaglandin-endoperoxide synthase 2	Homo sapiens	103-119
26664375-1	2015	As a continuous research for discovery of new COX-2 inhibitors, chemical synthesis, in vitro biological activity and molecular docking study of a new group of 1, 4-dihydropyridine (DHP) derivatives were presented.	dhp	181-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	46-51
23925891-9	2014	hCG, like DHP, is equally potent and induces oocyte maturation via DHP production in vitro.	dhp	67-70	hypertrichosis 2 (generalised, congenital)	Homo sapiens	0-3
23925891-10	2014	hCG with DHP has synergistic action on oocyte maturation in mullet ovary.	dhp	9-12	hypertrichosis 2 (generalised, congenital)	Homo sapiens	0-3
25582806-4	2015	It confirms that CPD* formation is efficiently quenched in this system by an easily accessible S2/S1 conical intersection located in the vicinity of the CPD* minimum and leading to a locally excited state minimum responsible for DHP luminescence.	dhp	229-232	carboxypeptidase D	Homo sapiens	17-21
25582806-4	2015	It confirms that CPD* formation is efficiently quenched in this system by an easily accessible S2/S1 conical intersection located in the vicinity of the CPD* minimum and leading to a locally excited state minimum responsible for DHP luminescence.	dhp	229-232	carboxypeptidase D	Homo sapiens	153-157
25582806-6	2015	The calculations show that CPD* formation is much more favorable in these systems, either due to an inversion of electronic states in DHP-1, suppressing the formation of the locally excited state, or due to efficient stabilization of CPD* on the S1 potential energy surface in DHP-2 and DHP-3.	dhp	134-137	carboxypeptidase D	Homo sapiens	27-31
25582806-6	2015	The calculations show that CPD* formation is much more favorable in these systems, either due to an inversion of electronic states in DHP-1, suppressing the formation of the locally excited state, or due to efficient stabilization of CPD* on the S1 potential energy surface in DHP-2 and DHP-3.	dhp	134-137	deoxyribonuclease 1 like 3	Homo sapiens	277-282
24943733-7	2014	DHP treatment reduced the macroscopic arthritic score, CRP levels, synovial inflammation, bone erosion and pannus formation.	dhp	0-3	C-reactive protein	Rattus norvegicus	55-58
23925891-4	2014	All the hormones (except DHP) and IGF-I increased DHP, E2 and testosterone productions by the postvitellogenic ovarian follicles in vitro.	dhp	50-53	insulin like growth factor 1	Homo sapiens	34-39
23925891-5	2014	DHP and testosterone productions were increased with the increase of incubation time from 9 h through 15 h. E2 production was not further increased beyond 12 h. DHP production was highest by hCG compared to other effectors.	dhp	0-3	hypertrichosis 2 (generalised, congenital)	Homo sapiens	191-194
23925891-5	2014	DHP and testosterone productions were increased with the increase of incubation time from 9 h through 15 h. E2 production was not further increased beyond 12 h. DHP production was highest by hCG compared to other effectors.	dhp	161-164	hypertrichosis 2 (generalised, congenital)	Homo sapiens	191-194
19741208-4	2010	Functional characterization of the receptor expressed in mammalian cells revealed that zebrafish Pgr exhibited progesterone-specific, dose-dependent induction of reporter gene expression, with 17 alpha,20 beta-dihydroxy-4-pregnen-3-one (DHP), a typical piscine progesterone, showing the highest potency.	dhp	237-240	progesterone receptor	Danio rerio	97-100
23409152-8	2013	A functional study of Kit involvement in final oocyte maturation showed that Kitlga and Kitlgb both suppressed the spontaneous maturation significantly; in contrast, Kitlgb but not Kitlga significantly promoted 17alpha, 20beta-dihydroxy-4-pregnen-3-one (DHP) -induced oocyte maturation.	dhp	254-257	KIT proto-oncogene, receptor tyrosine kinase a	Danio rerio	22-25
23409152-8	2013	A functional study of Kit involvement in final oocyte maturation showed that Kitlga and Kitlgb both suppressed the spontaneous maturation significantly; in contrast, Kitlgb but not Kitlga significantly promoted 17alpha, 20beta-dihydroxy-4-pregnen-3-one (DHP) -induced oocyte maturation.	dhp	254-257	kit ligand b	Danio rerio	166-172
24805225-3	2013	We extend DHP into a new algorithm that we call Value-Gradient Learning, VGL(lambda), and prove equivalence of an instance of the new algorithm to Backpropagation Through Time for Control with a greedy policy.	dhp	10-13	high density lipoprotein binding protein	Homo sapiens	73-76
22464183-2	2012	Here, we explore possible reciprocal interactions of 5-HT1A receptor knockout and the expression of BDNF, its receptor TrkB and downstream mitogen-activated protein kinase (MAPK) in the ventral (VHP) and dorsal hippocampus (DHP).	dhp	224-227	brain derived neurotrophic factor	Mus musculus	100-104
22464183-2	2012	Here, we explore possible reciprocal interactions of 5-HT1A receptor knockout and the expression of BDNF, its receptor TrkB and downstream mitogen-activated protein kinase (MAPK) in the ventral (VHP) and dorsal hippocampus (DHP).	dhp	224-227	mitogen-activated protein kinase 1	Mus musculus	173-177
21800850-4	2011	Sperm whale myoglobin (Mb) in the ferric state has a peroxidase activity ~10 times lower than that of DHP.	dhp	102-105	myoglobin	Physeter catodon	12-21
20382141-7	2010	Moreover, E2 and G-1 down-regulated the expression of membrane progestin receptor alpha (mPRalpha), the intermediary in DHP induction of OM.	dhp	120-123	progestin and adipoQ receptor family member VII, b	Danio rerio	54-87
20382141-7	2010	Moreover, E2 and G-1 down-regulated the expression of membrane progestin receptor alpha (mPRalpha), the intermediary in DHP induction of OM.	dhp	120-123	S100 calcium binding protein A6 (calcyclin)	Mus musculus	89-97
20382141-8	2010	Conversely DHP treatment caused a >50% decline in GPER mRNA levels.	dhp	11-14	G protein-coupled estrogen receptor 1	Danio rerio	53-57
19741208-8	2010	This stimulatory activity was blocked by a Pgr antagonist (RU486), suggesting that 11 beta-hydroxysteroid dehydrogenase activity was stimulated by DHP via Pgr.	dhp	147-150	progesterone receptor	Danio rerio	43-46
19741208-8	2010	This stimulatory activity was blocked by a Pgr antagonist (RU486), suggesting that 11 beta-hydroxysteroid dehydrogenase activity was stimulated by DHP via Pgr.	dhp	147-150	progesterone receptor	Danio rerio	155-158
16531089-2	2006	Treatment of postvitellogenic ovarian follicles with IGF-I and b-insulin increased concentration of maturation-inducing hormone (MIH), 17alpha,20beta-dihydroxy-4-pregnane-3-one (DHP) in the medium.	dhp	178-181	insulin like growth factor 1	Homo sapiens	53-58
18381682-2	2008	It was observed that the apparent retention factors of the DHP compounds on the AS phase in t-BuOH/n-Hex mobile phase had the largest reduction (>27%) among the mobile phases studied after a heating and cooling temperature cycle (10 to 50 back to 10 degrees C).	dhp	59-62	hematopoietically expressed homeobox	Homo sapiens	101-104
17580947-8	2007	cyt c shows no structural change and retains its activity when dissolved in the hydrated choline dhp, which is an excellent combination of chaotropic cation and kosmotropic anion.	dhp	97-100	cytochrome c, somatic	Homo sapiens	0-5
17580947-9	2007	Furthermore, cyt c dissolved in the hydrated choline dhp remained in a native state and was active after 18 months of storage at room temperature.	dhp	53-56	cytochrome c, somatic	Homo sapiens	13-18
17506543-1	2007	It is believed that the binding of pyrimidin-2-one to cytosine deaminase (CD) leads to the formation of 4-[R]-hydroxyl-3,4-dihydropyrimidine (DHP).	dhp	142-145	cytosine deaminase	Saccharomyces cerevisiae S288C	54-72
17089050-6	2006	In this study, we investigated the effects of this DHP treatment on serum levels and activities of TGF-beta, cellular immune responses, and anti-tumor effects in KDH-8 (TGF-beta-producing hepatocellular carcinoma cell line)-bearing rats.	dhp	51-54	transforming growth factor, beta 1	Rattus norvegicus	99-107
17089050-6	2006	In this study, we investigated the effects of this DHP treatment on serum levels and activities of TGF-beta, cellular immune responses, and anti-tumor effects in KDH-8 (TGF-beta-producing hepatocellular carcinoma cell line)-bearing rats.	dhp	51-54	transforming growth factor, beta 1	Rattus norvegicus	169-177
17089050-8	2006	DHP treatment decreased serum levels and activities of TGF-beta in tumor-bearing rats and restored T lymphocyte response to mitogen.	dhp	0-3	transforming growth factor, beta 1	Rattus norvegicus	55-63
17089050-12	2006	These results suggest that DHP treatment with an ISA column, which removes TGF-beta and other immunosuppressive substances from the sera of tumor-bearing hosts, is potentially a new immunotherapeutic strategy for cancer.	dhp	27-30	transforming growth factor, beta 1	Rattus norvegicus	75-83
18952087-4	2009	Both spontaneous and 17, 20beta-dihyroxy-4-pregnen-3-one (DHP)-induced maturation of follicle-enclosed zebrafish oocytes was significantly decreased when they were incubated with either estradiol-17beta, or the GPR30 agonists, ICI 182 780 and tamoxifen, or with the GPR30 specific agonist G-1.	dhp	58-61	G protein-coupled estrogen receptor 1	Danio rerio	211-216
18952087-4	2009	Both spontaneous and 17, 20beta-dihyroxy-4-pregnen-3-one (DHP)-induced maturation of follicle-enclosed zebrafish oocytes was significantly decreased when they were incubated with either estradiol-17beta, or the GPR30 agonists, ICI 182 780 and tamoxifen, or with the GPR30 specific agonist G-1.	dhp	58-61	G protein-coupled estrogen receptor 1	Danio rerio	266-271
17550604-12	2007	In contrast to inhibin, recombinant human activin A significantly enhanced DHP-induced GVBD in a dose-dependent manner after 48 hr, although activin alone was not able to induce GVBD without the presence of the steroid.	dhp	75-78	inhibin subunit beta E	Homo sapiens	42-49
16531089-6	2006	IGF-I was also able to stimulate DHP production in such follicles.	dhp	33-36	insulin like growth factor 1	Homo sapiens	0-5
16531089-7	2006	Addition of DHP and HCG to the culture of vitellogenic follicles containing IGF-I or b-insulin did neither potentiate the stimulation of GVBD induced by IGF-I nor initiate the same in response to b-insulin.	dhp	12-15	insulin like growth factor 1	Homo sapiens	76-81
16531089-12	2006	Cycloheximide was shown to inhibit the induction of GVBD and DHP production by IGF-I, b-insulin and HCG.	dhp	61-64	insulin like growth factor 1	Homo sapiens	79-84
16531089-16	2006	These uncouplers, however, inhibited DHP production induced by IGF-I, b-insulin and HCG.	dhp	37-40	insulin like growth factor 1	Homo sapiens	63-68
16076371-2	2005	We therefore investigated whether direct hemoperfusion (DHP) with a polymyxin B immobilized fiber column (PMX) could reduce the level of plasminogen activator inhibitor-1 (PAI-1), an index of vascular endothelial cell activation.	dhp	56-59	serpin family E member 1	Homo sapiens	137-170
16411665-7	2006	The MS/MS analyses confirmed the formation of N-propenal- (+54 Da) and dihydropyridine-type (DHP, +134 Da) adducts in both Lys29 and the N-terminus of insulin B chain.	dhp	93-96	insulin	Bos taurus	151-166
16076371-2	2005	We therefore investigated whether direct hemoperfusion (DHP) with a polymyxin B immobilized fiber column (PMX) could reduce the level of plasminogen activator inhibitor-1 (PAI-1), an index of vascular endothelial cell activation.	dhp	56-59	serpin family E member 1	Homo sapiens	172-177
16076371-5	2005	The PAI-1 value was 150+/-30.0 ng/mL before DHP with PMX, 178+/-60.0 ng/mL immediately after DHP with PMX, 90+/-22.1 ng/mL at 24 h after, 65+/-21.0 ng/mL at 48 h after, and 64+/-18.3 ng/mL 72 h after.	dhp	44-47	serpin family E member 1	Homo sapiens	4-9
10513599-10	1999	In conclusion, the present study demonstrated that the antagonist of 5-HT1A receptors, WAY100635, produced a more robust potentiation in the fluoxetine-induced 5-HT increases in the Pfc than Dhp.	dhp	191-194	5-hydroxytryptamine receptor 1A	Rattus norvegicus	69-75
15787563-5	2005	The second photoreaction process is photocyclization of cis-BSF, which occurs to give DP1 decaying with the half lifetime (tau1/2) of 2.8-4.0 micros to produce another DHP-type intermediate (DP2) with an absorption peak at 400 nm in the absence of O2, through [1,9]-hydrogen shift.	dhp	168-171	transcription factor Dp-1	Homo sapiens	86-89
15787563-5	2005	The second photoreaction process is photocyclization of cis-BSF, which occurs to give DP1 decaying with the half lifetime (tau1/2) of 2.8-4.0 micros to produce another DHP-type intermediate (DP2) with an absorption peak at 400 nm in the absence of O2, through [1,9]-hydrogen shift.	dhp	168-171	transcription factor Dp-2	Homo sapiens	191-194
10513599-11	1999	Since Pfc and Dhp are predominately innervated by 5-HT neurons located in the DRN and MRN respectively, this result may indicate a functional difference between the 5-HT1A autoreceptors located on the cell bodies of 5-HT neurons in the DRN and MRN.	dhp	14-17	5-hydroxytryptamine receptor 1A	Rattus norvegicus	165-171
9576753-4	1998	SMCs exposed to EDHB or DHP attached normally to collagen- and vitronectin-coated substrates; however, spreading on collagen but not vitronectin was inhibited.	dhp	24-27	vitronectin	Homo sapiens	63-74
8928907-5	1996	Treatment with mEGF and hTGF-alpha stimulated GVBD from a basal level of 8.5 to approximately 30% with an estimated half-maximal effective dose for EGF of 5.80 +/- 0.82 + 10(-10) and for hTGF-alpha, 1.9 +/- 1.0 x 10(-10) M. Furthermore, treatment with mEGF marginally increased 17 alpha, 20 beta-dihydroxy-4-pregnen-3-one (DHP)-induced GVBD without significantly influencing the gonadotropin-induced response.	dhp	323-326	transforming growth factor alpha	Homo sapiens	24-34
8998493-2	1996	Content for the DHP-1 was derived following in-depth interviews with 25 insulin dependent and insulin requiring patients, a review of the literature and discussions with health care professionals.	dhp	16-19	insulin	Homo sapiens	72-79
8998493-2	1996	Content for the DHP-1 was derived following in-depth interviews with 25 insulin dependent and insulin requiring patients, a review of the literature and discussions with health care professionals.	dhp	16-19	insulin	Homo sapiens	94-101
8998493-3	1996	Initial analysis of the factor structure of the DHP-1 was carried out on the responses of 239 insulin dependent and insulin requiring patients, with a mean age of 40.85 years (SD = 13.0), resulting in a 43 item three factor solution.	dhp	48-51	insulin	Homo sapiens	94-101
8998493-3	1996	Initial analysis of the factor structure of the DHP-1 was carried out on the responses of 239 insulin dependent and insulin requiring patients, with a mean age of 40.85 years (SD = 13.0), resulting in a 43 item three factor solution.	dhp	48-51	insulin	Homo sapiens	116-123
33776906-10	2021	After correcting for confounders and multiple comparisons, insulin-users reported significantly worse outcomes on vitality (SF-36, adjusted difference -5.7, p=0.033), general health (SF-36, adjusted difference -4.8, p=0.043), barriers to activity (DHP, adjusted difference -7.2, p<0.001), and psychological distress (DHP, adjusted difference -3.7, p=0.004), all on a 0-100 scale.	dhp	248-251	insulin	Homo sapiens	59-66
8498903-7	1993	Dialysis with a combination of direct hemoperfusion (DHP) and an adsorption column led to the elimination of more than 200-300 mg of beta 2-M.	dhp	53-56	beta-2-microglobulin	Homo sapiens	133-141
2107257-1	1990	The inhibitors of C1q biosynthesis and secretion, 3,4-dehydro-DL-proline (DHP) and 2,2"-dipyridyl, were previously shown to suppress murine macrophage FcR-dependent phagocytosis and cytolysis of IgG-opsonized RBC targets.	dhp	74-77	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	18-21
2107257-1	1990	The inhibitors of C1q biosynthesis and secretion, 3,4-dehydro-DL-proline (DHP) and 2,2"-dipyridyl, were previously shown to suppress murine macrophage FcR-dependent phagocytosis and cytolysis of IgG-opsonized RBC targets.	dhp	74-77	Fc receptor	Mus musculus	151-154
2107257-4	1990	Inhibition of C1q secretion by DHP-treated macrophages was confirmed both by a complement hemolytic assay and by autoradiographic analysis of [35S]methionine-labeled culture supernatants.	dhp	31-34	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	14-17
2107257-5	1990	DHP-treated macrophages were inhibited in their response to direct activation and triggering of IFN-gamma-primed macrophages by lipid A, Poly I:C, and cobra venom factor for tumor cytotoxicity.	dhp	0-3	interferon gamma	Mus musculus	96-105
2107257-7	1990	The addition of exogenous purified C1q (2 micrograms/ml) to macrophages after DHP treatment, reconstituted their response to activation for both antibody-independent and antibody-dependent tumor cytotoxicity.	dhp	78-81	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	35-38
33776906-10	2021	After correcting for confounders and multiple comparisons, insulin-users reported significantly worse outcomes on vitality (SF-36, adjusted difference -5.7, p=0.033), general health (SF-36, adjusted difference -4.8, p=0.043), barriers to activity (DHP, adjusted difference -7.2, p<0.001), and psychological distress (DHP, adjusted difference -3.7, p=0.004), all on a 0-100 scale.	dhp	317-320	insulin	Homo sapiens	59-66
35225789-4	2022	In support of this hypothesis, we show that knockout of cyp17a1 leads to accumulation of 17alpha,20beta-dihydroxy-4-pregnen-3-one (DHP) and P4.	dhp	131-134	cytochrome P450, family 17, subfamily A, polypeptide 1	Danio rerio	56-63
35380122-5	2022	In culture, Lepr LOF attenuates the effect of 17alpha-20beta-dihydroxy-4 pregnen-3-one (DHP) in promoting germinal vesicle breakdown (GVBD) and increases the rate of GVBD as well as attenuates the rate of oocyte atresia.	dhp	88-91	leptin receptor	Danio rerio	12-16
35225789-5	2022	Further, administration of progestin, a synthetic DHP mimetic, is sufficient to rescue testicular development and spermatogenesis in ar-/- zebrafish, whereas knockout of npgr abolishes the rescue effect of cyp17a1-/- in the cyp17a1-/-;ar-/- double mutant.	dhp	50-53	androgen receptor	Danio rerio	133-135
32798647-5	2020	LC-MS/MS analysis revealed the formation of 1-hydroxymethyl-7-hydroxy-6,7-dihydropyrrolizine (DHP), the main reactive metabolite of PAs, in CYP3A4-expressing TK6 cells.	dhp	94-97	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	140-146
35208954-3	2022	The DHP molecules exhibited concentration-dependent inhibition of LasR and PqsR receptor proteins.	dhp	4-7	transcriptional regulator LasR	Pseudomonas aeruginosa PAO1	66-70
6180581-6	1982	Progesterone showed a similar multicomponent interaction but differed from DHP in the extent of binding to CBG.	dhp	75-78	serpin family A member 6	Homo sapiens	107-110
3028650-4	1987	DP was more potent than DHP in blocking FcR effector functions in a reversible fashion and neither inhibitor affected M phi C3b receptor function.	dhp	24-27	Fc receptor	Mus musculus	40-43
32798647-6	2020	DHP was also detected in CYP3A5- and 3A7-expressing cells after PA exposure, but to a much lesser extent.	dhp	0-3	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	25-31
32600357-11	2020	CONCLUSIONS: This study identified a novel pathogenic stop gain mutation in DPYS gene in a DHP deficient patient.	dhp	91-94	dihydropyrimidinase	Homo sapiens	76-80
32472544-5	2020	CONCLUSION: The compound heterozygous variants of the DPYS gene probably underlie the DHP in this child.	dhp	86-89	dihydropyrimidinase	Homo sapiens	54-58
31416030-4	2019	In this study, new synthetic 1,4 dihydropiridine (DHP) derivatives containing thiophenyl substitution were tested as inhibitors of P-gp.	dhp	50-53	ATP binding cassette subfamily B member 1	Homo sapiens	131-135
31982399-2	2020	Carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase (CR/20beta-HSD) is a candidate enzyme responsible for DHP production during oocyte maturation in various fish, including Nile tilapia.	dhp	114-117	carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase	Oreochromis niloticus	0-59
31982399-4	2020	17beta-HSD12 (presumably orthologous to salmon 17beta-HSD12L) has been detected in Nile tilapia; however, its enzymatic activity and specific ability to convert the DHP substrate 17alpha-hydroxyprogesterone (17OHP) have not been examined.	dhp	165-168	hydroxysteroid 17-beta dehydrogenase 12	Homo sapiens	0-12
31982399-5	2020	This study aimed to determine whether CR/20beta-HSD or 17beta-HSD12 is responsible for DHP production during oocyte maturation in the Nile tilapia.	dhp	87-90	hydroxysteroid 17-beta dehydrogenase 12	Homo sapiens	55-67
31982399-7	2020	HEK293T cells transfected with hsd17b12 exhibited a strong ability to convert exogenous 17OHP to DHP (73.8% yield).	dhp	97-100	hydroxysteroid 17-beta dehydrogenase 12	Homo sapiens	31-39
31982399-14	2020	The present study strongly suggests that 17beta-HSD12, and not CR/20beta-HSD, is the 20beta-HSD responsible for DHP production by ovarian follicles during oocyte maturation in Nile tilapia.	dhp	112-115	hydroxysteroid 17-beta dehydrogenase 12	Homo sapiens	41-53
31628987-13	2020	Indeed 17alpha, 20beta-dihydroxy-4-pregnen-3-one (DHP) was increased 17 h and 24 h after injection with rGnRH/GAP and spawning stemmed from that injection.	dhp	50-53	gonadotropin releasing hormone 1	Rattus norvegicus	104-109
31416030-7	2019	Flow cytometric analysis revealed that synthetic DHP derivatives (15 microM) increased intracellular concentration of the substrate by 2-3 folds compared with verapamil as a standard P-gp inhibitor.	dhp	49-52	ATP binding cassette subfamily B member 1	Homo sapiens	183-187
31292739-1	2019	Syn and anti dihydropyrene (DHP) are excellent thermochromes, and therefore extensively studied for their thermochromic and photochromic properties, respectively.	dhp	28-31	synemin	Homo sapiens	0-3
31292739-10	2019	Comparison of the activation barriers for syn (30.18 kcal mol-1) and anti (32.10 kcal mol-1) dimethyldihydropyrenes for radical pathway reveal that decomposition of syn- DHP is more facile over anti-, which is consistent with the experimental observation.	dhp	170-173	synemin	Homo sapiens	42-45
31292739-10	2019	Comparison of the activation barriers for syn (30.18 kcal mol-1) and anti (32.10 kcal mol-1) dimethyldihydropyrenes for radical pathway reveal that decomposition of syn- DHP is more facile over anti-, which is consistent with the experimental observation.	dhp	170-173	synemin	Homo sapiens	165-168
29705270-1	2018	It was documented that 17alpha, 20beta-dihydroxy-4-pregnen-3-one (DHP), a fish specific progestin, might play critical roles in spermatogenesis, sperm maturation and spermiation partially through activating nuclear receptor (Pgr).	dhp	66-69	progesterone receptor	Oreochromis niloticus	225-228
31013427-3	2019	In this paper, we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitors starting from a high-throughput screen and the lead-optimization of this series from a lead with minimal rat oral exposure to the identification of dihydropyrazole 77 with good pharmacokinetic profiles in multiple species.	dhp	87-90	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	92-96
31013427-3	2019	In this paper, we report on the design of potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitors starting from a high-throughput screen and the lead-optimization of this series from a lead with minimal rat oral exposure to the identification of dihydropyrazole 77 with good pharmacokinetic profiles in multiple species.	dhp	87-90	tribbles pseudokinase 3	Rattus norvegicus	97-103
29705270-12	2018	Taken together, our data suggested that DHP-activated physiology via pgr is crucial for the fertility in the XY tilapia.	dhp	40-43	progesterone receptor	Oreochromis niloticus	69-72
29649418-1	2018	Although previous studies suggest membrane progesterone receptor alpha (mPRalpha/Paqr7) mediates 17, 20beta-dihydroxy-4-pregnen-3-one (DHP) induction of oocyte maturation (OM) in zebrafish, critical information needed to establish mPRalpha as the receptor mediating OM is lacking.	dhp	135-138	S100 calcium binding protein A6 (calcyclin)	Mus musculus	72-80
29649418-1	2018	Although previous studies suggest membrane progesterone receptor alpha (mPRalpha/Paqr7) mediates 17, 20beta-dihydroxy-4-pregnen-3-one (DHP) induction of oocyte maturation (OM) in zebrafish, critical information needed to establish mPRalpha as the receptor mediating OM is lacking.	dhp	135-138	S100 calcium binding protein A6 (calcyclin)	Mus musculus	231-239
29649418-3	2018	Microinjection of pertussis toxin blocked DHP induction of OM and the progestin-induced decrease in cyclic AMP levels, suggesting mPRalpha activates an inhibitory G protein (Gi).	dhp	42-45	S100 calcium binding protein A6 (calcyclin)	Mus musculus	130-138
29649418-4	2018	Microinjection of morpholino antisense oligonucleotides to zebrafish pgrmc1 blocked induction of OM by DHP which was accompanied by decreased levels of Pgrmc1 and mPRalpha on the oocyte plasma membranes.	dhp	103-106	progesterone receptor membrane component 1	Danio rerio	69-75
29649418-5	2018	Similarly, treatment of denuded oocytes with a PGRMC1 inhibitor, AG205, blocked the gonadotropin-induced increase in plasma membrane mPRalpha levels and attenuated DHP induction of OM.	dhp	164-167	progesterone receptor membrane component 1	Danio rerio	47-53
29649418-6	2018	Co-incubation with two inhibitors of epidermal growth factor Erbb2, ErbB2 inhibitor II and AG 879, prevented induction of OM by DHP, indicating the likely involvement of Erbb2 in mPRalpha-mediated signaling.	dhp	128-131	erb-b2 receptor tyrosine kinase 2	Danio rerio	61-66
29649418-6	2018	Co-incubation with two inhibitors of epidermal growth factor Erbb2, ErbB2 inhibitor II and AG 879, prevented induction of OM by DHP, indicating the likely involvement of Erbb2 in mPRalpha-mediated signaling.	dhp	128-131	erb-b2 receptor tyrosine kinase 2	Danio rerio	68-73
29649418-6	2018	Co-incubation with two inhibitors of epidermal growth factor Erbb2, ErbB2 inhibitor II and AG 879, prevented induction of OM by DHP, indicating the likely involvement of Erbb2 in mPRalpha-mediated signaling.	dhp	128-131	S100 calcium binding protein A6 (calcyclin)	Mus musculus	179-187
29655979-1	2018	During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against ROCK2.	dhp	165-168	AKT serine/threonine kinase 1	Homo sapiens	74-77
29655979-1	2018	During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against ROCK2.	dhp	165-168	AKT serine/threonine kinase 1	Homo sapiens	211-214
29655979-1	2018	During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against ROCK2.	dhp	165-168	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	250-255
28911864-3	2018	The key activation event involves the rearrangement of the HAMP-DHp helical core and translation of the CA towards the acceptor histidine, which presumably results in an autokinase-competent complex.	dhp	64-67	hepcidin antimicrobial peptide	Homo sapiens	59-63
27981890-3	2018	In a previous report, we synthesized some 14-dihydropyridine (DHP) derivatives as inhibitors of human P-gp.	dhp	62-65	ATP binding cassette subfamily B member 1	Homo sapiens	102-106
29431188-1	2018	DJ-1 was recently reported to mediate the cardioprotection of delayed hypoxic preconditioning (DHP) by suppressing hypoxia/reoxygenation (H/R)-induced oxidative stress, but its mechanism against H/R-induced oxidative stress during DHP is not fully elucidated.	dhp	95-98	Parkinsonism associated deglycase	Rattus norvegicus	0-4
29431188-1	2018	DJ-1 was recently reported to mediate the cardioprotection of delayed hypoxic preconditioning (DHP) by suppressing hypoxia/reoxygenation (H/R)-induced oxidative stress, but its mechanism against H/R-induced oxidative stress during DHP is not fully elucidated.	dhp	231-234	Parkinsonism associated deglycase	Rattus norvegicus	0-4
29431188-4	2018	However, the aforementioned effects of DHP were antagonized by DJ-1 knockdown with short hairpin RNA but mimicked by DJ-1 overexpression.	dhp	39-42	Parkinsonism associated deglycase	Rattus norvegicus	63-67
29431188-4	2018	However, the aforementioned effects of DHP were antagonized by DJ-1 knockdown with short hairpin RNA but mimicked by DJ-1 overexpression.	dhp	39-42	Parkinsonism associated deglycase	Rattus norvegicus	117-121
29431188-6	2018	Taken together, this work revealed that preserving mitochondrial complex I activity and subsequently inhibiting mitochondrial ROS generation could be a novel mechanism by which DJ-1 mediates the cardioprotection of DHP against H/R-induced oxidative stress damage.	dhp	215-218	Parkinsonism associated deglycase	Rattus norvegicus	177-181
28784540-2	2017	This work evaluated the effect of DHP (up to three passes at 100, 150 and 200MPa, with an inlet temperature of 20 C) on functional and structural properties of bovine serum albumin (BSA).	dhp	34-37	albumin	Homo sapiens	167-180