PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
21109191-2	2010	Here we study the role of the lipoprotein lipase inhibitor Angptl4 in the response to dietary saturated fat.	saturated	94-103	lipoprotein lipase	Mus musculus	30-48
21109191-2	2010	Here we study the role of the lipoprotein lipase inhibitor Angptl4 in the response to dietary saturated fat.	saturated	94-103	angiopoietin-like 4	Mus musculus	59-66
20221766-4	2010	In contrast, a high-saturated fat/low-sugar diet protects mice with impaired mitochondrial metabolism from diet-induced obesity by increasing total energy expenditure and increasing expression of ACAA2, a rate-limiting enzyme of mitochondrial beta-oxidation, whereas no concomitant improvement of glucose metabolism was observed.	saturated	20-29	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)	Mus musculus	196-201
20601073-10	2010	In conclusion, this study showed that a PUFA supplementation with C18:2, C18:3 or C22:6 in bovine culture development for 6 days and co-culture with Boec down-regulate mRNA expression of proteins involved in lipid metabolism in d 7-8 embryo (SCD1 and FADS2 desaturases), probably through SREBP1 mRNA regulation after 10microM C22:6 supplementation, indicating a modification of saturated/unsaturated fatty acid balance in bovine blastocyst.	saturated	378-387	PUFA	Bos taurus	40-44
18394213-12	2008	In contrast, one of the better designed studies found that consumption of a high-saturated-fat diet decreased insulin sensitivity in comparison to a high-monounsaturated-fat diet.	saturated	81-90	insulin	Homo sapiens	110-117
19777326-1	2010	Stearoyl-CoA desaturase-1 (SCD-1) is the rate limiting enzyme in the biosynthesis of saturated-derived monounsaturated fats that are the major constituents of very-low-density-lipoproteins-triacylglycerol (VLDL-TAG) and are involved in regulating cellular metabolism.	saturated	85-94	stearoyl-CoA desaturase	Rattus norvegicus	0-25
19777326-1	2010	Stearoyl-CoA desaturase-1 (SCD-1) is the rate limiting enzyme in the biosynthesis of saturated-derived monounsaturated fats that are the major constituents of very-low-density-lipoproteins-triacylglycerol (VLDL-TAG) and are involved in regulating cellular metabolism.	saturated	85-94	stearoyl-CoA desaturase	Rattus norvegicus	27-32
19116776-1	2009	Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol.	saturated	136-145	fatty acid binding protein 1, liver	Mus musculus	0-32
19116776-1	2009	Liver fatty acid binding protein (L-FABP) is highly expressed in both enterocytes and hepatocytes and binds multiple ligands, including saturated (SFA), unsaturated fatty acids (PUFA), and cholesterol.	saturated	136-145	fatty acid binding protein 1, liver	Mus musculus	34-40
19627255-0	2009	Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet.	saturated	113-122	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	0-41
19627255-0	2009	Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet.	saturated	113-122	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	43-48
19627255-1	2009	The hypothesis that PDHK4 (pyruvate dehydrogenase kinase isoenzyme 4) has potential as a target for the treatment of type 2 diabetes was tested by feeding wild-type and PDHK4 knockout mice a high saturated fat diet that induces hyperglycemia, hyperinsulinaemia, glucose intolerance, hepatic steatosis and obesity.	saturated	196-205	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	20-25
19627255-1	2009	The hypothesis that PDHK4 (pyruvate dehydrogenase kinase isoenzyme 4) has potential as a target for the treatment of type 2 diabetes was tested by feeding wild-type and PDHK4 knockout mice a high saturated fat diet that induces hyperglycemia, hyperinsulinaemia, glucose intolerance, hepatic steatosis and obesity.	saturated	196-205	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	27-68
18402553-9	2008	Biochemical analysis of transgenic plants with regards to fatty acids associated with relevant lipids indicates that lipids increasing with PIS1 overexpression were enriched in saturated or monounsaturated fatty acids, whereas lipids increasing with PIS2 overexpression, including polyphosphoinositides, contained more unsaturated fatty acids.	saturated	177-186	phosphatidylinositol synthase 1	Arabidopsis thaliana	140-144
18513372-3	2008	We found that E-FABP binds to a broad range of saturated and unsaturated LCFFAs, including those with potential interest for neuronal differentiation and axonal growth such as C22:6n-3 docosahexaenoic acid (DHA), C20:5n-3 eicosapentaenoic acid (EPA), and C20:4n-6 arachidonic acid (ARA).	saturated	47-56	fatty acid binding protein 5	Rattus norvegicus	14-20
18238778-4	2008	Substrate specificity studies suggested that AGPAT6 was active against both saturated and unsaturated long-chain fatty acyl-CoAs.	saturated	76-85	glycerol-3-phosphate acyltransferase 4	Homo sapiens	45-51
18066610-4	2008	Stearoyl-CoA desaturase (SCD) converts saturated to monounsaturated fatty acids and is a key enzyme in lipogenesis.	saturated	39-48	stearoyl-CoA desaturase	Homo sapiens	0-23
18066610-4	2008	Stearoyl-CoA desaturase (SCD) converts saturated to monounsaturated fatty acids and is a key enzyme in lipogenesis.	saturated	39-48	stearoyl-CoA desaturase	Homo sapiens	25-28
18283280-0	2008	High saturated-fat diet induces apoptosis in rat enterocytes and blunts GIP and insulin-secretive response to oral glucose load.	saturated	5-14	gastric inhibitory polypeptide	Rattus norvegicus	72-75
18283280-2	2008	We hypothesized that a high saturated-fat diet can induce duodenal enterocyte apoptosis and impair gastric inhibitory polypeptide (GIP) secretion.	saturated	28-37	gastric inhibitory polypeptide	Rattus norvegicus	131-134
18283280-11	2008	A high saturated-fat diet stimulates GIP secretion but with time induces apoptosis of duodenal villi epithelium, showing for the first time that enterocytes are also prone to lipoapoptosis.	saturated	7-16	gastric inhibitory polypeptide	Rattus norvegicus	37-40
18218763-4	2008	Saturated FA (14:0, 16:0, and 17:0) and milk fat percentage showed negative loading for PC1.	saturated	0-9	proprotein convertase subtilisin/kexin type 1	Bos taurus	88-91
17201745-13	2007	The mRNA levels of PPAR-regulated genes were increased by the high saturated and unsaturated fat diets compared with standard chow or the medium chain fatty acid chow.	saturated	67-76	peroxisome proliferator activated receptor alpha	Rattus norvegicus	19-23
17936398-11	2008	These results suggest RELMbeta expression to be regulated directly by nutrients such as glucose and saturated free fatty acids including stearic acid, as well as by hormones including insulin and TNFalpha.	saturated	100-109	resistin like beta	Homo sapiens	22-30
16685042-5	2006	RESULTS: The 26%-carbohydrate, low-saturated-fat diet reduced triacylglycerol, apolipoprotein B, small LDL mass, and total:HDL cholesterol and increased LDL peak diameter.	saturated	35-44	apolipoprotein B	Homo sapiens	79-95
16732014-0	2006	Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet.	saturated	117-126	perilipin 1	Homo sapiens	0-9
16732014-0	2006	Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet.	saturated	117-126	insulin	Homo sapiens	61-68
16403234-1	2006	BACKGROUND: It is speculated that high saturated fat very low carbohydrate diets (VLCARB) have adverse effects on cardiovascular risk but evidence for this in controlled studies is lacking.	saturated	39-48	FAT atypical cadherin 1	Homo sapiens	49-52
16532273-9	2006	In conclusion, prolonged exposure to saturated palmitic acid induces lipoapoptosis in exocrine pancreatic AR42J cells, through disturbance of the Bax/Bcl-2 balance.	saturated	37-46	BCL2 associated X, apoptosis regulator	Rattus norvegicus	146-149
16532273-9	2006	In conclusion, prolonged exposure to saturated palmitic acid induces lipoapoptosis in exocrine pancreatic AR42J cells, through disturbance of the Bax/Bcl-2 balance.	saturated	37-46	BCL2, apoptosis regulator	Rattus norvegicus	150-155
16150913-0	2005	Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of insulin receptor substrate-1 and protein kinase B in muscle during the initial stages of in vivo insulin stimulation.	saturated	5-14	insulin receptor substrate 1	Rattus norvegicus	75-103
15920059-9	2005	CONCLUSIONS: These data indicate that physical inactivity and a high-saturated fat diet may interact to reduce whole-body insulin sensitivity.	saturated	69-78	insulin	Homo sapiens	122-129
15855323-1	2005	Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis.	saturated	69-78	stearoyl-CoA desaturase	Homo sapiens	31-54
15855323-1	2005	Fatty acid desaturases such as steaoryl-CoA desaturase (SCD) convert saturated to unsaturated fatty acids and are involved in lipogenesis.	saturated	69-78	stearoyl-CoA desaturase	Homo sapiens	56-59
15080344-9	2004	In the BF outer layer of the OUT pigs, the higher PUFA content was compensated by both a lower (P < 0.01) saturated and monounsaturated fatty acid (MUFA) content, whereas in the OF, LM, and dark portion of the ST, only the percentage of MUFA was decreased (P < 0.01).	saturated	109-118	Polyunsaturated fatty acid percentage	Sus scrofa	50-54
14627740-6	2003	The protein-fatty acid interaction was specific, as saturated C18 fatty acids, or unsaturated C18:1trans conformers were unable to form complexes with apo alpha-lactalbumin, as were fatty acids with shorter or longer carbon chains.	saturated	52-61	Bardet-Biedl syndrome 9	Homo sapiens	62-65
14749269-2	2004	We have attempted to analyze the role of PPAR-alpha-linked fatty acid metabolism in islet function in health and in insulin-resistant states linked to lifestyle factors, in particular pregnancy and a diet inappropriately high in saturated fat.	saturated	229-238	peroxisome proliferator activated receptor alpha	Homo sapiens	41-51
12716789-6	2003	Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively.	saturated	0-9	C-reactive protein	Homo sapiens	106-124
12933670-7	2003	Our data demonstrate that the insulin response to glucose is suppressed to a greater extent than whole-body insulin sensitivity is enhanced by enrichment of a high-saturated fat diet with long-chain omega-3 fatty acids.	saturated	164-173	insulin	Homo sapiens	30-37
12933670-7	2003	Our data demonstrate that the insulin response to glucose is suppressed to a greater extent than whole-body insulin sensitivity is enhanced by enrichment of a high-saturated fat diet with long-chain omega-3 fatty acids.	saturated	164-173	insulin	Homo sapiens	108-115
12716789-6	2003	Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively.	saturated	0-9	interleukin 6	Homo sapiens	145-149
12716789-6	2003	Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively.	saturated	25-34	C-reactive protein	Homo sapiens	106-124
12716789-6	2003	Saturated-to-omega-3 and saturated-to-omega-6 FA ratios were significantly and positively associated with C-reactive protein (P < 0.0001) and IL-6 (P < 0.001), respectively.	saturated	25-34	interleukin 6	Homo sapiens	145-149
12489064-5	2002	PON1 activity (mean +/- SD) was 195.9 +/- 108.9 U/L after 4 weeks of consuming a diet with 22.9% of energy (en%) from saturated fat and 184.5 +/- 99.3 U/L when 9.3 en% from saturated fat was replaced by trans fat (P =.006).	saturated	118-127	paraoxonase 1	Homo sapiens	0-4
16256480-2	2003	A good colloidal dispersion and saturated amine intercalates of the aluminophosphate can be obtained in solutions with dielectric constants in the range 50-70 and an amine concentration of 10 mmol/g AlP.	saturated	32-41	ATHS	Homo sapiens	199-202
12770552-0	2003	A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor.	saturated	2-11	brain-derived neurotrophic factor	Rattus norvegicus	131-164
12455996-1	2002	In Saccharomyces cerevisiae, OLE1 encodes a delta9 fatty acid desaturase, an enzyme that plays a critical role in maintaining the correct ratio of saturated to monounsaturated fatty acids in the cell membrane.	saturated	147-156	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	29-33
12006366-3	2002	One week of feeding with a highly saturated fat diet resulted in ~50 and 20% reduction in hypothalamic arcuate NPY and AgRP mRNA levels, respectively, compared with a low-fat or an n-3 or n-6 polyunsaturated high-fat (PUFA) diet without change in energy intake, fat mass, plasma leptin levels, and leptin receptor or POMC mRNA.	saturated	34-43	agouti related neuropeptide	Mus musculus	119-123
12006366-3	2002	One week of feeding with a highly saturated fat diet resulted in ~50 and 20% reduction in hypothalamic arcuate NPY and AgRP mRNA levels, respectively, compared with a low-fat or an n-3 or n-6 polyunsaturated high-fat (PUFA) diet without change in energy intake, fat mass, plasma leptin levels, and leptin receptor or POMC mRNA.	saturated	34-43	leptin	Mus musculus	279-285
12006366-3	2002	One week of feeding with a highly saturated fat diet resulted in ~50 and 20% reduction in hypothalamic arcuate NPY and AgRP mRNA levels, respectively, compared with a low-fat or an n-3 or n-6 polyunsaturated high-fat (PUFA) diet without change in energy intake, fat mass, plasma leptin levels, and leptin receptor or POMC mRNA.	saturated	34-43	leptin	Mus musculus	298-304
12006366-3	2002	One week of feeding with a highly saturated fat diet resulted in ~50 and 20% reduction in hypothalamic arcuate NPY and AgRP mRNA levels, respectively, compared with a low-fat or an n-3 or n-6 polyunsaturated high-fat (PUFA) diet without change in energy intake, fat mass, plasma leptin levels, and leptin receptor or POMC mRNA.	saturated	34-43	pro-opiomelanocortin-alpha	Mus musculus	317-321
12145222-15	2002	Overweight individuals were more susceptible to developing insulin resistance on high-saturated fat diets.	saturated	86-95	insulin	Homo sapiens	59-66
11314848-6	2001	The personalised intervention produced significant decreases in total and saturated fat intake, compared with the control group.	saturated	74-83	FAT atypical cadherin 1	Homo sapiens	84-87
11677241-1	2002	The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the synthesis of unsaturated fatty acids, is physiologically important because the ratio of saturated to unsaturated fatty acids is thought to control cellular functions by modulating the structural integrity and fluidity of cell membranes.	saturated	94-103	stearoyl-CoA desaturase	Homo sapiens	18-41
11677241-1	2002	The regulation of stearoyl-CoA desaturase (SCD), a rate-limiting enzyme in the synthesis of unsaturated fatty acids, is physiologically important because the ratio of saturated to unsaturated fatty acids is thought to control cellular functions by modulating the structural integrity and fluidity of cell membranes.	saturated	94-103	stearoyl-CoA desaturase	Homo sapiens	43-46
11314848-7	2001	Total-fat decreased by 8.6% (versus 0.2% in the control group); saturated fat decreased by 9.3% (versus 1.7% in the control group).	saturated	64-73	FAT atypical cadherin 1	Homo sapiens	74-77
10889805-12	2000	It shows that a high-monounsaturated-fat diet significantly improves insulin sensitivity compared to a high-saturated-fat diet.	saturated	27-36	insulin	Homo sapiens	69-76
10871558-11	2000	CONCLUSIONS: The isoenergetic substitution of a high-saturated fatty acid diet with an NCEP Step I or a high-monounsaturated fatty acid diet decreases plasma CETP concentrations.	saturated	53-62	cholesteryl ester transfer protein	Homo sapiens	158-162
10687887-4	1999	The insulin-sensitizing properties of many vegan diets--high in fiber, low in saturated fat--should amplify these effects by down-regulating insulin secretion.	saturated	78-87	insulin	Homo sapiens	4-11
1320939-5	1992	Translocation of PAP-1 activity in the hepatocytes is preferentially promoted by unsaturated fatty acids (C18:1, C18:2, C18:3, C20:4 and C20:5), rather than by saturated acids (C14:0, C16:0, C18:0).	saturated	83-92	regenerating family member 3 beta	Rattus norvegicus	17-22
10328215-6	1999	A slight increase in risk observed for intake of saturated fat was largely due to an increased risk in cases without p53 over-expression (OR per 16.1 g/day, 1.46; 95% CI, 1.08-1.97), and no association in cases with p53 over-expression (OR, 1.07, 95% CI, 0.78-1.47).	saturated	49-58	tumor protein p53	Homo sapiens	117-120
10328215-6	1999	A slight increase in risk observed for intake of saturated fat was largely due to an increased risk in cases without p53 over-expression (OR per 16.1 g/day, 1.46; 95% CI, 1.08-1.97), and no association in cases with p53 over-expression (OR, 1.07, 95% CI, 0.78-1.47).	saturated	49-58	tumor protein p53	Homo sapiens	216-219
9374734-4	1997	In lambs with long-term exposure to betamethasone, there was a similar, dose-dependent increase in concentrations of saturated phosphatidylcholine and surfactant proteins A (SP-A) and B (SP-B) (maximal 2- to 3-fold in tissue and 10- to 15-fold in lavage fluid).	saturated	117-126	pulmonary surfactant-associated protein B	Ovis aries	187-191
8617357-1	1996	Two different crystal forms of the 9 kDa protein of the signal recognition particle (SRP9) have been prepared by the hanging drop vapor diffusion technique using 28% (w/v) PEG8000 or 28% saturated ammonium sulphate as precipitant.	saturated	187-196	signal recognition particle 9	Mus musculus	85-89
1324716-0	1992	Protein rotational diffusion and lipid/protein interactions in recombinants of bovine rhodopsin with saturated diacylphosphatidylcholines of different chain lengths studied by conventional and saturation-transfer electron spin resonance.	saturated	101-110	rhodopsin	Bos taurus	86-95
9831639-8	1998	In conclusion, the modifications observed in postprandial lipoprotein metabolism associated with this polymorphism within the apoA-IV gene locus may be involved in the variability in LDL-CH response observed in subjects consuming high saturated fat diets.	saturated	235-244	apolipoprotein A4	Homo sapiens	126-133
8631965-1	1996	In Saccharomyces cerevisiae, unsaturated fatty acids are formed from saturated acyl-CoA precursors by Ole1p, a delta-9 fatty acid desaturase.	saturated	31-40	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	102-107
7877894-7	1994	This effect of amount of dietary fat on prolactin in proestrus-estrus animals anesthetized with ether was predominantly present in animals fed polyunsaturated fat (p < 0.05, 1-way ANOVA and Tukey"s test) and was statistically not significant in rats fed saturated fat diets.	saturated	149-158	prolactin	Rattus norvegicus	40-49
7877894-8	1994	During metestrus-diestrus, prolactin levels were significantly lower in animals fed a high-saturated fat diet than in those fed low-saturated fat, low-unsaturated fat, or high-unsaturated fat diets, independent of the blood sampling conditions (p < 0.05, 2-way ANOVA and Tukey"s test).	saturated	91-100	prolactin	Rattus norvegicus	27-36
7877894-8	1994	During metestrus-diestrus, prolactin levels were significantly lower in animals fed a high-saturated fat diet than in those fed low-saturated fat, low-unsaturated fat, or high-unsaturated fat diets, independent of the blood sampling conditions (p < 0.05, 2-way ANOVA and Tukey"s test).	saturated	132-141	prolactin	Rattus norvegicus	27-36
1898333-3	1991	In the presence of CaCl2, collagen- and thrombin-induced aggregation of washed platelets from the saturated-fat dietary group (with highest level of arachidonate) was low compared with that of platelets from the other dietary groups, despite a relatively high production of thromboxane B2.	saturated	98-107	coagulation factor II	Rattus norvegicus	40-48
3262189-5	1988	Peaks 2 and 3 were observed, while Peak 1 completely disappeared with the labeled-cytosol precipitated at 40% saturated ammonium sulfate.	saturated	110-119	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	35-41
2741497-1	1989	There are figures to the natural occurrence of saturated and unsaturated odd numbered fatty acids (C11 to C21) in food stuffs.	saturated	47-56	RNA polymerase III subunit K	Homo sapiens	99-102
2741497-1	1989	There are figures to the natural occurrence of saturated and unsaturated odd numbered fatty acids (C11 to C21) in food stuffs.	saturated	47-56	TBL1X/Y related 1	Homo sapiens	106-109
3675712-4	1987	The results indicate that cholesterol-containing atherogenic diets with either primarily saturated or polyunsaturated fat have similar potential for the increase of LPL activity.	saturated	89-98	lipoprotein lipase	Macaca fascicularis	165-168
7285004-9	1981	During the postinitiation phase, both high-unsaturated-fat diets but not the high-saturated-fat diet significantly elevated the pancreatic neoplasm incidence.	saturated	45-54	FAT atypical cadherin 1	Rattus norvegicus	55-58
7061456-8	1982	In particular, the ratio of released saturated to unsaturated fatty acids was significantly higher with the acidic enzyme as compared with the basic phospholipase A2.	saturated	37-46	phospholipase A2 group IB	Homo sapiens	149-165
6112057-4	1981	Guanylate cyclase activation by large amounts (50 microL) of saturated amyl nitrite gas did not require, but was enhanced by, the addition of thiols or ascorbate.	saturated	61-70	guanylate cyclase	Bos taurus	0-17
6112057-5	1981	However, similar to sodium nitrite, guanylate cyclase activation by smaller amounts (5 microL) of saturated amyl nitrite gas did require the addition of one of various thiols or ascorbate.	saturated	98-107	guanylate cyclase	Bos taurus	36-53
197573-2	1977	The existence of marked differences in the degradation rate for each phospholipid suggests a relationship between the alteration of phosphatidylcholine containing one saturated and one unsaturated fatty acid and the decrease in activity of glucose-6-phosphatase; the inactivation of this enzyme was unrelated to the alteration of other phospholipids.	saturated	167-176	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	240-261
6768948-0	1980	Interaction of human plasma high density lipoprotein HDL2 with synthetic saturated phosphatidylcholines.	saturated	73-82	junctophilin 3	Homo sapiens	53-57
191161-1	1977	Several spin-labelled phospholipids carrying covalently bound 5-doxylstearic acid (2-(3-carboxydecyl)-2-hexyl-4,4-dimethyl-3-oxazolidinoxyl) were intercalated in liposomes of saturated and unsaturated lecithins.	saturated	175-184	spindlin 1	Homo sapiens	8-12
30871020-11	2019	This study highlights an increased content of saturated ceramides in aging which could be speculated to influence insulin sensitivity.	saturated	46-55	insulin	Homo sapiens	114-121
31080589-11	2019	These exploratory analyses suggest that addition of MFGM to a high-saturated fat meal modifies postprandial insulin response and offers a protective role for those individuals with higher baseline Chol:HDL.	saturated	67-76	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	52-56
1035847-1	1976	Hydrolysis of ethers of saturated and unsaturated alcohols and ethers, e.g. phenol and choline, under the action of horse blood serum cholinesterase, was studied.	saturated	24-33	butyrylcholinesterase	Homo sapiens	134-148
188490-0	1976	[Interaction of spin-labeled saturated and unsaturated fatty acid derivatives with biological membrane lipid and protein components].	saturated	29-38	spindlin 1	Homo sapiens	16-20
167554-5	1975	ADH catalyses interconversion of a large variety of saturated and unsaturated aliphatic and aromatic alcohols and the corresponding aldehydes and ketones utilizing NAD(H).	saturated	52-61	aldo-keto reductase family 1 member A1	Homo sapiens	0-3
1116880-1	1975	Both saturated (SFA) and unsaturated fatty acids (UFS) inhibited PHA- and PPD-induced lymphocyte transformation.	saturated	5-14	lamin B receptor	Homo sapiens	65-68
33419037-5	2021	Among these, the rs110817643C>T, located in the seed sequence of the bta-miR-1291, was associated with different omega6 FAs, polyunsaturated FA, and polyunsaturated:saturated FA ratios.	saturated	131-140	microRNA 1291	Bos taurus	69-81
31297627-3	2020	Serum levels of cholecystokinin (CCK) are elevated in mice and humans that consume a high-saturated fat diet.	saturated	90-99	cholecystokinin	Mus musculus	16-31
31297627-3	2020	Serum levels of cholecystokinin (CCK) are elevated in mice and humans that consume a high-saturated fat diet.	saturated	90-99	cholecystokinin	Mus musculus	33-36
31085628-0	2019	High-saturated-fat diet-induced obesity causes hepatic interleukin-6 resistance via endoplasmic reticulum stress.	saturated	5-14	interleukin 6	Mus musculus	55-68
31209255-2	2019	TGRL from subjects consuming a high saturated fat test meal elicited a variable inflammatory response in TNFalpha-stimulated endothelial cells (EC) that correlated strongly with the polyunsaturated fatty acid (PUFA) content.	saturated	36-45	tumor necrosis factor	Homo sapiens	105-113
29626089-6	2018	Depletion of E-FABP not only inhibited SA-induced CD11c upregulation in macrophages in vitro but also abrogated high-saturated-fat diet-induced skin lesions in obese mouse models in vivo.	saturated	117-126	fatty acid binding protein 5, epidermal	Mus musculus	13-19
30411851-0	2019	High-Saturated Fat High-Sugar Diet Accelerates Left-Ventricular Dysfunction Faster than High-Saturated Fat Diet Alone via Increasing Oxidative Stress and Apoptosis in Obese-Insulin Resistant Rats.	saturated	5-14	FAT atypical cadherin 1	Rattus norvegicus	15-18
28644713-0	2018	An unstructured loop that is critical for interactions of the stalk domain of Drp1 with saturated phosphatidic acid.	saturated	88-97	dynamin 1 like	Homo sapiens	78-82
30127714-5	2018	Objective: In this study, we determined the extent to which a 3 month diet enriched in the saturated free fatty acid palmitate (PA) influences levels of alpha-syn and tyrosine hydroxylase, the rate limiting enzyme in dopamine synthesis in mice brains.	saturated	91-100	synuclein, alpha	Mus musculus	153-162
28886012-5	2017	In particular, we use dietary supplements or mutated E. coli as food, together with direct measurements of membrane fluidity and composition, to show that diets containing a high ratio of saturated to monounsaturated fatty acids cause membrane rigidity and lethality in the paqr-2 mutant.	saturated	188-197	Progestin and AdipoQ Receptor family	Caenorhabditis elegans	274-280
29122443-7	2018	Correlation analyses revealed significant and positive relationships of saturated LPC, BCAA, AAA, and Glu with blood pressure, glucose, triglycerides, apolipoprotein B, and high-sensitivity C-reactive protein, while unsaturated LPC, Gln, Gln/Glu, and 25-hydroxyvitamin D exhibited an opposite trend.	saturated	72-81	apolipoprotein B	Homo sapiens	151-167
29122443-7	2018	Correlation analyses revealed significant and positive relationships of saturated LPC, BCAA, AAA, and Glu with blood pressure, glucose, triglycerides, apolipoprotein B, and high-sensitivity C-reactive protein, while unsaturated LPC, Gln, Gln/Glu, and 25-hydroxyvitamin D exhibited an opposite trend.	saturated	72-81	C-reactive protein	Homo sapiens	190-208
28797843-3	2017	We have previously shown that Stearoyl-CoA-desaturase 1 (SCD1), the enzyme responsible for the conversion of saturated to monounsaturated fatty acids is upregulated in 3D lung cancer spheroids and is an upstream activator of key proliferation pathways beta-catenin and YAP/TAZ.	saturated	109-118	stearoyl-CoA desaturase	Homo sapiens	30-55
28797843-3	2017	We have previously shown that Stearoyl-CoA-desaturase 1 (SCD1), the enzyme responsible for the conversion of saturated to monounsaturated fatty acids is upregulated in 3D lung cancer spheroids and is an upstream activator of key proliferation pathways beta-catenin and YAP/TAZ.	saturated	109-118	stearoyl-CoA desaturase	Homo sapiens	57-61
28797843-3	2017	We have previously shown that Stearoyl-CoA-desaturase 1 (SCD1), the enzyme responsible for the conversion of saturated to monounsaturated fatty acids is upregulated in 3D lung cancer spheroids and is an upstream activator of key proliferation pathways beta-catenin and YAP/TAZ.	saturated	109-118	catenin beta 1	Homo sapiens	252-264
28797843-3	2017	We have previously shown that Stearoyl-CoA-desaturase 1 (SCD1), the enzyme responsible for the conversion of saturated to monounsaturated fatty acids is upregulated in 3D lung cancer spheroids and is an upstream activator of key proliferation pathways beta-catenin and YAP/TAZ.	saturated	109-118	Yes1 associated transcriptional regulator	Homo sapiens	269-272
28797843-3	2017	We have previously shown that Stearoyl-CoA-desaturase 1 (SCD1), the enzyme responsible for the conversion of saturated to monounsaturated fatty acids is upregulated in 3D lung cancer spheroids and is an upstream activator of key proliferation pathways beta-catenin and YAP/TAZ.	saturated	109-118	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	273-276
27653088-12	2017	As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP.	saturated	50-59	C-reactive protein	Homo sapiens	134-137
28526391-0	2017	Withdrawal from high-carbohydrate, high-saturated-fat diet changes saturated fat distribution and improves hepatic low-density-lipoprotein receptor expression to ameliorate metabolic syndrome in rats.	saturated	40-49	low density lipoprotein receptor	Rattus norvegicus	115-147
27596631-1	2017	OLE1 of Saccharomyces cerevisiae encodes the sole and essential Delta-9 desaturase catalyzing the conversion of saturated to unsaturated fatty acids.	saturated	112-121	stearoyl-CoA 9-desaturase	Saccharomyces cerevisiae S288C	0-4
28096099-0	2017	High-Saturated-Fat Diet Increases Circulating Angiotensin-Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient-Dependent Increases of Blood Pressure.	saturated	5-14	angiotensin I converting enzyme	Homo sapiens	46-75
28096099-10	2017	The GG genotype of the ACE rs4343 polymorphism represents a robust nutrigenetic marker for an unfavorable response to high-saturated-fat diets.	saturated	123-132	angiotensin I converting enzyme	Homo sapiens	23-26
27297560-5	2016	Conversely, in transgenic ZmSAD1 RNAi Arabidopsis seeds, the contents of stearic acid and long-chain saturated acids and the ratio of saturated to unsaturated fatty acids were significantly increased; in addition, the oleic acid content was significantly decreased.	saturated	101-110	shikimate dehydrogenase 1	Zea mays	26-32
26427403-4	2016	One member of the family of elongases, ELOngation of Very Long chain fatty acids-4 (ELOVL4), mediates the biosynthesis of both saturated and unsaturated very long chain fatty acids (VLC-FA; > C26) in the retina, meibomian gland, brain, skin, and testis.	saturated	127-136	ELOVL fatty acid elongase 4	Homo sapiens	84-90
27375435-9	2016	In conclusion, our data indicate that the substitution of saturated by unsaturated fatty acids in the diet has beneficial effects on modulation of hypothalamic inflammation and function in obesity, underlying, at hypothalamic level, the interaction among insulin and/or leptin resistance, AMPK activation and hyperphagia.	saturated	58-67	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	289-293
27099231-0	2016	A High-Saturated-Fat, High-Sucrose Diet Aggravates Bone Loss in Ovariectomized Female Rats.	saturated	7-16	FAT atypical cadherin 1	Rattus norvegicus	17-20
27099231-1	2016	BACKGROUND: Estrogen deficiency in women and high-saturated fat, high-sucrose (HFS) diets have both been recognized as risk factors for metabolic syndrome.	saturated	50-59	FAT atypical cadherin 1	Homo sapiens	60-63
26383539-0	2016	Maternal saturated-fat-rich diet promotes leptin resistance in fetal liver lipid catabolism and programs lipid homeostasis impairments in the liver of rat offspring.	saturated	9-18	leptin	Rattus norvegicus	42-48
26556368-9	2015	Diets rich in saturated (SFA) as compared to monounsaturated (MUFA) or polyunsaturated (PUFA) fatty acids appear particularly harmful as they increase both liver fat and insulin resistance.	saturated	14-23	insulin	Homo sapiens	170-177
26410780-0	2015	Saturated lipids decrease mitofusin 2 leading to endoplasmic reticulum stress activation and insulin resistance in hypothalamic cells.	saturated	0-9	mitofusin 2	Mus musculus	26-37
26433148-7	2015	Different FAs had different effects on ER stress: most notably, saturated palmitic acid significantly affected the UPR response, as demonstrated by altered Xbp1 splicing, elevation in transcript levels of UPR (Xbp, CHOP, Bip) and immune factors (Tnfalpha, Tgfbeta), and enhanced Xbp1 protein levels and Xbp1 time-dependent nuclear translocation.	saturated	64-73	X-box binding protein 1	Rattus norvegicus	156-160
26433148-7	2015	Different FAs had different effects on ER stress: most notably, saturated palmitic acid significantly affected the UPR response, as demonstrated by altered Xbp1 splicing, elevation in transcript levels of UPR (Xbp, CHOP, Bip) and immune factors (Tnfalpha, Tgfbeta), and enhanced Xbp1 protein levels and Xbp1 time-dependent nuclear translocation.	saturated	64-73	DNA-damage inducible transcript 3	Rattus norvegicus	215-219
26433148-7	2015	Different FAs had different effects on ER stress: most notably, saturated palmitic acid significantly affected the UPR response, as demonstrated by altered Xbp1 splicing, elevation in transcript levels of UPR (Xbp, CHOP, Bip) and immune factors (Tnfalpha, Tgfbeta), and enhanced Xbp1 protein levels and Xbp1 time-dependent nuclear translocation.	saturated	64-73	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	221-224
26433148-7	2015	Different FAs had different effects on ER stress: most notably, saturated palmitic acid significantly affected the UPR response, as demonstrated by altered Xbp1 splicing, elevation in transcript levels of UPR (Xbp, CHOP, Bip) and immune factors (Tnfalpha, Tgfbeta), and enhanced Xbp1 protein levels and Xbp1 time-dependent nuclear translocation.	saturated	64-73	tumor necrosis factor	Rattus norvegicus	246-254
26433148-7	2015	Different FAs had different effects on ER stress: most notably, saturated palmitic acid significantly affected the UPR response, as demonstrated by altered Xbp1 splicing, elevation in transcript levels of UPR (Xbp, CHOP, Bip) and immune factors (Tnfalpha, Tgfbeta), and enhanced Xbp1 protein levels and Xbp1 time-dependent nuclear translocation.	saturated	64-73	transforming growth factor, beta 1	Rattus norvegicus	256-263
26433148-7	2015	Different FAs had different effects on ER stress: most notably, saturated palmitic acid significantly affected the UPR response, as demonstrated by altered Xbp1 splicing, elevation in transcript levels of UPR (Xbp, CHOP, Bip) and immune factors (Tnfalpha, Tgfbeta), and enhanced Xbp1 protein levels and Xbp1 time-dependent nuclear translocation.	saturated	64-73	X-box binding protein 1	Rattus norvegicus	279-283
26433148-7	2015	Different FAs had different effects on ER stress: most notably, saturated palmitic acid significantly affected the UPR response, as demonstrated by altered Xbp1 splicing, elevation in transcript levels of UPR (Xbp, CHOP, Bip) and immune factors (Tnfalpha, Tgfbeta), and enhanced Xbp1 protein levels and Xbp1 time-dependent nuclear translocation.	saturated	64-73	X-box binding protein 1	Rattus norvegicus	279-283
25557809-2	2015	The stearoyl-CoA desaturase (SCD) gene plays a crucial role in the conversion of saturated FAs into monounsaturated FAs (MUFAs), and hence, is among the candidate genes responsible for pig fatness traits.	saturated	81-90	stearoyl-CoA desaturase	Sus scrofa	4-27
25557809-2	2015	The stearoyl-CoA desaturase (SCD) gene plays a crucial role in the conversion of saturated FAs into monounsaturated FAs (MUFAs), and hence, is among the candidate genes responsible for pig fatness traits.	saturated	81-90	stearoyl-CoA desaturase	Sus scrofa	29-32
24531201-5	2014	Incorporation of the complexes within bovine beta-lactoglobulin (betaLG) as the protein host was studied by circular dichroism and fluorescence spectroscopy and again noticeable differences were observed between the saturated and unsaturated fatty acid derivatives.	saturated	216-225	beta-lactoglobulin	Bos taurus	45-63
24532085-12	2014	Identification of FTO rs9939609 reinforces the importance of adequate fruit, vegetable and folate and restriction of saturated/trans fat intake in the diet.	saturated	117-126	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	18-21
24357007-1	2014	Stearoyl-CoA desaturase (SCD, SCD1), an endoplasmic reticulum (ER) resident protein and a rate-limiting enzyme in monounsaturated fatty acid biosynthesis, regulates cellular functions by controlling the ratio of saturated to monounsaturated fatty acids.	saturated	120-129	stearoyl-CoA desaturase	Homo sapiens	0-23
24357007-1	2014	Stearoyl-CoA desaturase (SCD, SCD1), an endoplasmic reticulum (ER) resident protein and a rate-limiting enzyme in monounsaturated fatty acid biosynthesis, regulates cellular functions by controlling the ratio of saturated to monounsaturated fatty acids.	saturated	120-129	stearoyl-CoA desaturase	Homo sapiens	25-28
24357007-1	2014	Stearoyl-CoA desaturase (SCD, SCD1), an endoplasmic reticulum (ER) resident protein and a rate-limiting enzyme in monounsaturated fatty acid biosynthesis, regulates cellular functions by controlling the ratio of saturated to monounsaturated fatty acids.	saturated	120-129	stearoyl-CoA desaturase	Homo sapiens	30-34
24378307-3	2014	It was found that the cross-plots of FAME ratios, for example, the sum of the di-unsaturated relative to saturated homologues of FAMEs (D/S) versus the sum of the mono-saturated to saturated FAMEs (M/S), and the sum of di-unsaturated to mono-saturated FAMEs (D/M) versus the sum of the mono-saturated to saturated FAMEs (M/S), could cluster samples clearly into their individual feedstock.	saturated	83-92	benign adult familial myoclonic epilepsy 1	Homo sapiens	37-41
24690233-2	2014	FABP2 has a high affinity for saturated and unsaturated long-chain fatty acids and is believed to be involved in the absorption and transport of dietary fatty acids.	saturated	30-39	fatty acid binding protein 2	Homo sapiens	0-5
22921758-5	2012	The gas-chromatographic (GC) analysis of saturated/unsaturated fatty acids" release patterns from intact mitochondrial and erythrocyte membranes after the addition of RVVA-PLA2-I showed a distinctly different result.	saturated	41-50	phospholipase A2, group V	Mus musculus	172-176
24309934-6	2013	One of the most strongly upregulated gene was stearoyl-CoA desaturase (SCD1), the main enzyme responsible for the conversion of saturated into monounsaturated fatty acids.	saturated	128-137	stearoyl-CoA desaturase	Homo sapiens	46-69
24309934-6	2013	One of the most strongly upregulated gene was stearoyl-CoA desaturase (SCD1), the main enzyme responsible for the conversion of saturated into monounsaturated fatty acids.	saturated	128-137	stearoyl-CoA desaturase	Homo sapiens	71-75
23261534-5	2013	There was a trend towards a positive relationship between FAS and Delta6d protein expression and saturated and polyunsaturated fatty acids content respectively, in subcutaneous fat but not in muscle.	saturated	97-106	fatty acid synthase	Sus scrofa	58-61
21941003-5	2011	The toxic saturated free fatty acid palmitate induces an increase in DR5 mRNA and protein expression in Huh-7 human hepatoma cells leading to DR5 localization into lipid rafts, cell surface receptor clustering with subsequent recruitment of the initiator caspase-8, and ultimately cellular demise.	saturated	10-19	TNF receptor superfamily member 10b	Homo sapiens	69-72
22875341-9	2012	The present study indicates that prenatal and early postnatal exposure to a high-saturated-fat diet suppresses the development of skeletal muscle and myogenic genes via Wnt/beta-catenin signaling, and the inappropriate muscle development could potentially contribute to the predisposition of offspring to develop metabolic-syndrome-like phenotype in adulthood.	saturated	81-90	catenin beta 1	Rattus norvegicus	173-185
22366768-6	2012	In this study, we examined the modulation of the PGL1 promoter in E. coli, and the results indicated that its activity is greatly induced by saturated digalacturonic acid and is indirectly regulated by the transcriptional regulators the 2-keto-3-deoxygluconate repressor.	saturated	141-150	endo-polygalacturonase	Saccharomyces cerevisiae S288C	49-53
21447441-2	2012	Mice fed a high-fat diet, especially that of saturated-fat-rich oil, develop fatty liver with an increase in peroxisome proliferator-activated receptor (PPAR) gamma2 protein in liver.	saturated	45-54	peroxisome proliferator activated receptor gamma	Mus musculus	109-165
22575042-0	2012	A lower proportion of dietary saturated/monounsaturated/polyunsaturated fatty acids reduces the expression of adiponectin in rats fed a high-fat diet.	saturated	30-39	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	110-121
22037452-2	2011	The aim of the present study was to investigate the effects of estrogens on liver apoptotic damage and changes in SMP30 expression induced by a high saturated fatty acid diet (HSFD).	saturated	149-158	regucalcin	Mus musculus	114-119
21941003-5	2011	The toxic saturated free fatty acid palmitate induces an increase in DR5 mRNA and protein expression in Huh-7 human hepatoma cells leading to DR5 localization into lipid rafts, cell surface receptor clustering with subsequent recruitment of the initiator caspase-8, and ultimately cellular demise.	saturated	10-19	caspase 8	Homo sapiens	255-264
21941003-5	2011	The toxic saturated free fatty acid palmitate induces an increase in DR5 mRNA and protein expression in Huh-7 human hepatoma cells leading to DR5 localization into lipid rafts, cell surface receptor clustering with subsequent recruitment of the initiator caspase-8, and ultimately cellular demise.	saturated	10-19	TNF receptor superfamily member 10b	Homo sapiens	142-145
20938723-3	2011	In control and sedentary rats, diets enriched with saturated, monounsaturated, and polyunsaturated fatty acids (PUFA) enhanced the expression of the PPARalpha target genes carnitine palmitoyltransferase 1 and acyl-CoA oxidase, the highest effect being exerted by omega-3.	saturated	51-60	peroxisome proliferator activated receptor alpha	Rattus norvegicus	149-158
20935562-3	2011	RECENT FINDINGS: Epidemiological cohort studies reported an association between a high saturated to monounsaturated fatty acid ratio measured in blood lipids, indicating low stearoyl-CoA desaturase-1 activity, and decreased breast cancer risk.	saturated	87-96	stearoyl-CoA desaturase	Homo sapiens	174-197
21209459-6	2011	We explored the consequences of the changes of ALDRP expression levels on the fatty acid content (saturated, monounsaturated, and polyunsaturated fatty acids) in phospholipids as well as on the levels of beta-oxidation of 3 suspected substrates: C26:0, C24:0, and C22:6n-3 (DHA).	saturated	98-107	ATP binding cassette subfamily D member 2	Homo sapiens	47-52