PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34806108-0	2021	Isorhamnetin, the xanthine oxidase inhibitor from Sophora japonica, ameliorates uric acid levels and renal function in hyperuricemic mice.	3-methylquercetin	0-12	xanthine dehydrogenase	Mus musculus	18-34
34329714-13	2021	In hOATP1B1-HEK293 cells, kaempferol and isorhamnetin contributed to the inhibition of OATP1B1-mediated uptake of 3H-ES with IC50 values of 3.28 +- 1.08 muM and 46.12 +- 5.25 muM, respectively.	3-methylquercetin	41-53	solute carrier organic anion transporter family member 1B1	Homo sapiens	87-94
34096286-4	2021	Mechanistically, isorhamnetin stimulated the expression of the proliferating cell nuclear antigen and C-myc and promoted the proliferation of GCs via the PI3K/Akt signaling pathway.	3-methylquercetin	17-29	AKT serine/threonine kinase 1	Homo sapiens	159-162
34680909-0	2021	Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome.	3-methylquercetin	0-12	ataxia telangiectasia mutated	Mus musculus	67-70
34680909-4	2021	Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells.	3-methylquercetin	9-21	transformation related protein 53, pseudogene	Mus musculus	32-35
34680909-4	2021	Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells.	3-methylquercetin	9-21	ataxia telangiectasia mutated	Mus musculus	77-106
34680909-4	2021	Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells.	3-methylquercetin	9-21	ataxia telangiectasia mutated	Mus musculus	108-111
34680909-4	2021	Although isorhamnetin moderated p53 activity, it promoted phosphorylation of ataxia telangiectasia mutated (ATM) and enhanced 53BP1 recruitment in irradiated cells.	3-methylquercetin	9-21	transformation related protein 53 binding protein 1	Mus musculus	126-131
34680909-5	2021	The radioprotective effect of isorhamnetin was not observed in the presence of ATM inhibitor, indicating that its protective effect was dependent on ATM.	3-methylquercetin	30-42	ataxia telangiectasia mutated	Mus musculus	149-152
34680909-7	2021	These findings suggested that isorhamnetin enhances the ATM-dependent DNA repair process, which is presumably associated with the suppressive effect against GI syndrome.	3-methylquercetin	30-42	ataxia telangiectasia mutated	Mus musculus	56-59
34269571-5	2021	The results show that ISO targeted PI3K and blocked the PI3K-AKT-mTOR signaling pathway, significantly inhibiting gastric cancer cell autophagy in a hypoxic environment, inhibiting cell proliferation, decreasing mitochondrial membrane potential, and promoting mitochondria-mediated apoptosis.	3-methylquercetin	22-25	AKT serine/threonine kinase 1	Homo sapiens	61-64
34269571-5	2021	The results show that ISO targeted PI3K and blocked the PI3K-AKT-mTOR signaling pathway, significantly inhibiting gastric cancer cell autophagy in a hypoxic environment, inhibiting cell proliferation, decreasing mitochondrial membrane potential, and promoting mitochondria-mediated apoptosis.	3-methylquercetin	22-25	mechanistic target of rapamycin kinase	Homo sapiens	65-69
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	3-methylquercetin	57-69	tumor protein p53	Homo sapiens	131-135
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	3-methylquercetin	57-69	AKT serine/threonine kinase 1	Homo sapiens	137-141
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	3-methylquercetin	57-69	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	147-150
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	3-methylquercetin	57-69	AKT serine/threonine kinase 1	Homo sapiens	160-163
34306252-10	2021	The main compounds of XYS include Quercetin, Naringenin, Isorhamnetin, and Stigmasterol, which mainly regulate the targets such as TP53, Akt1, and MYC and PI3K/Akt, p53, and cell cycle signal pathways.	3-methylquercetin	57-69	tumor protein p53	Homo sapiens	165-168
34744756-0	2021	Corrigendum: Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Homo sapiens	103-106
34606526-0	2021	Isorhamnetin attenuates high-fat and high-fructose diet induced cognitive impairments and neuroinflammation by mediating MAPK and NFkappaB signaling pathways.	3-methylquercetin	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-138
34606526-6	2021	Notably, the ISO treatment activated the CREB/BDNF pathway and increased neurotrophic factors in the brains of mice.	3-methylquercetin	13-16	cAMP responsive element binding protein 1	Mus musculus	41-45
34606526-6	2021	Notably, the ISO treatment activated the CREB/BDNF pathway and increased neurotrophic factors in the brains of mice.	3-methylquercetin	13-16	brain derived neurotrophic factor	Mus musculus	46-50
34606526-9	2021	In conclusion, these results indicated that ISO mitigated HFFD-induced cognitive impairments by inhibiting the MAPK and NFkappaB signaling pathways, suggesting that ISO might be a plausible nutritional intervention for metabolic syndrome-related cognitive complications.	3-methylquercetin	44-47	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-128
34606526-9	2021	In conclusion, these results indicated that ISO mitigated HFFD-induced cognitive impairments by inhibiting the MAPK and NFkappaB signaling pathways, suggesting that ISO might be a plausible nutritional intervention for metabolic syndrome-related cognitive complications.	3-methylquercetin	165-168	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-128
34096286-0	2021	Isorhamnetin Promotes Estrogen Biosynthesis and Proliferation in Porcine Granulosa Cells via the PI3K/Akt Signaling Pathway.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	102-105
34096286-3	2021	We found that isorhamnetin promoted the secretion of estrogen and inhibited the secretion of progesterone and testosterone by modulating steroidogenesis-associated proteins and mRNA such as CYP19A1, StAR, and 3beta-HSD in ovarian GCs.	3-methylquercetin	14-26	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	190-197
34096286-3	2021	We found that isorhamnetin promoted the secretion of estrogen and inhibited the secretion of progesterone and testosterone by modulating steroidogenesis-associated proteins and mRNA such as CYP19A1, StAR, and 3beta-HSD in ovarian GCs.	3-methylquercetin	14-26	steroidogenic acute regulatory protein	Homo sapiens	199-203
34096286-4	2021	Mechanistically, isorhamnetin stimulated the expression of the proliferating cell nuclear antigen and C-myc and promoted the proliferation of GCs via the PI3K/Akt signaling pathway.	3-methylquercetin	17-29	proliferating cell nuclear antigen	Homo sapiens	63-97
34096286-4	2021	Mechanistically, isorhamnetin stimulated the expression of the proliferating cell nuclear antigen and C-myc and promoted the proliferation of GCs via the PI3K/Akt signaling pathway.	3-methylquercetin	17-29	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
34096286-5	2021	Furthermore, isorhamnetin increased the protein expression of CyclinB, CyclinD, CyclinE, and CyclinA, thereby raising the ratio of S-phase cells in response to GC proliferation.	3-methylquercetin	13-25	cyclin A2	Homo sapiens	93-100
34096286-6	2021	Changes in the expression of apoptosis-associated proteins (Bcl2, Bax, and cytochrome c) and intracellular reactive oxygen species levels showed that isorhamnetin inhibited GC apoptosis.	3-methylquercetin	150-162	BCL2 apoptosis regulator	Homo sapiens	60-64
34096286-6	2021	Changes in the expression of apoptosis-associated proteins (Bcl2, Bax, and cytochrome c) and intracellular reactive oxygen species levels showed that isorhamnetin inhibited GC apoptosis.	3-methylquercetin	150-162	BCL2 associated X, apoptosis regulator	Homo sapiens	66-69
34096286-6	2021	Changes in the expression of apoptosis-associated proteins (Bcl2, Bax, and cytochrome c) and intracellular reactive oxygen species levels showed that isorhamnetin inhibited GC apoptosis.	3-methylquercetin	150-162	cytochrome c, somatic	Homo sapiens	75-87
34096286-7	2021	Collectively, these findings indicate that isorhamnetin regulates steroidogenesis through the activation of PI3K/Akt, which promotes proliferation, inhibits apoptosis, and alleviates oxidative stress.	3-methylquercetin	43-55	AKT serine/threonine kinase 1	Homo sapiens	113-116
34065697-0	2021	Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways.	3-methylquercetin	14-26	aryl hydrocarbon receptor	Homo sapiens	118-121
34065697-0	2021	Quercetin and Isorhamnetin Attenuate Benzo(a)pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways.	3-methylquercetin	14-26	NFE2 like bZIP transcription factor 2	Homo sapiens	126-130
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	3-methylquercetin	27-39	aryl hydrocarbon receptor	Homo sapiens	69-94
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	3-methylquercetin	27-39	aryl hydrocarbon receptor	Homo sapiens	96-99
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	3-methylquercetin	27-39	NFE2 like bZIP transcription factor 2	Homo sapiens	105-148
34065697-9	2021	Furthermore, quercetin and isorhamnetin induced the translocation of aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (NRF2), which regulate the expression level of phase enzymes.	3-methylquercetin	27-39	NFE2 like bZIP transcription factor 2	Homo sapiens	150-154
35359022-8	2022	Additionally, isorhamnetin alleviated pathological changes of the liver tissue and suitably reversed NF-kB and Nrf2 immunoreactivity.	3-methylquercetin	14-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
35577160-11	2022	Furthermore, the GO enrichment analysis showed that corydine, isorhamnetin, and bicuculline were enriched in "RUNX2 regulates osteoblast differentiation", significantly increased alkaline phosphatase activity and calcium deposition and upregulated runt-related transcription factor 2 mRNA and protein expression and osteocalcin mRNA expression in HUMSCs, suggesting that these compounds promoted the mesenchymal stem cell (MSC) osteogenic transformation.	3-methylquercetin	62-74	RUNX family transcription factor 2	Homo sapiens	110-115
35577160-11	2022	Furthermore, the GO enrichment analysis showed that corydine, isorhamnetin, and bicuculline were enriched in "RUNX2 regulates osteoblast differentiation", significantly increased alkaline phosphatase activity and calcium deposition and upregulated runt-related transcription factor 2 mRNA and protein expression and osteocalcin mRNA expression in HUMSCs, suggesting that these compounds promoted the mesenchymal stem cell (MSC) osteogenic transformation.	3-methylquercetin	62-74	RUNX family transcription factor 2	Homo sapiens	248-283
35577160-11	2022	Furthermore, the GO enrichment analysis showed that corydine, isorhamnetin, and bicuculline were enriched in "RUNX2 regulates osteoblast differentiation", significantly increased alkaline phosphatase activity and calcium deposition and upregulated runt-related transcription factor 2 mRNA and protein expression and osteocalcin mRNA expression in HUMSCs, suggesting that these compounds promoted the mesenchymal stem cell (MSC) osteogenic transformation.	3-methylquercetin	62-74	bone gamma-carboxyglutamate protein	Homo sapiens	316-327
35502492-8	2022	Isorhamnetin treatment significantly reduced the APAP-induced increase in the liver weight and liver index; it also reduced the APAP-induced increase in serum liver parameters (ALT, AST, ALP, and LDH) (p < 0.05).	3-methylquercetin	0-12	glutamic pyruvic transaminase, soluble	Mus musculus	177-180
35502492-8	2022	Isorhamnetin treatment significantly reduced the APAP-induced increase in the liver weight and liver index; it also reduced the APAP-induced increase in serum liver parameters (ALT, AST, ALP, and LDH) (p < 0.05).	3-methylquercetin	0-12	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	182-185
35502492-8	2022	Isorhamnetin treatment significantly reduced the APAP-induced increase in the liver weight and liver index; it also reduced the APAP-induced increase in serum liver parameters (ALT, AST, ALP, and LDH) (p < 0.05).	3-methylquercetin	0-12	alopecia, recessive	Mus musculus	187-190
35502492-9	2022	Isorhamnetin significantly reduced APAP-induced oxidative stress and inflammation by increasing TAS levels and decreasing TOS, TNF-alpha, IL-1beta, and IL-6 levels (p < 0.05).	3-methylquercetin	0-12	tumor necrosis factor	Mus musculus	127-136
35502492-9	2022	Isorhamnetin significantly reduced APAP-induced oxidative stress and inflammation by increasing TAS levels and decreasing TOS, TNF-alpha, IL-1beta, and IL-6 levels (p < 0.05).	3-methylquercetin	0-12	interleukin 1 alpha	Mus musculus	138-146
35502492-9	2022	Isorhamnetin significantly reduced APAP-induced oxidative stress and inflammation by increasing TAS levels and decreasing TOS, TNF-alpha, IL-1beta, and IL-6 levels (p < 0.05).	3-methylquercetin	0-12	interleukin 6	Mus musculus	152-156
35489264-6	2022	Molecular docking indicated that gallic acid stably bound to the active site of PPO, while isorhamnetin had low affinity on PPO.	3-methylquercetin	91-103	catechol oxidase B, chloroplastic	Solanum tuberosum	80-83
35489264-6	2022	Molecular docking indicated that gallic acid stably bound to the active site of PPO, while isorhamnetin had low affinity on PPO.	3-methylquercetin	91-103	catechol oxidase B, chloroplastic	Solanum tuberosum	124-127
35359022-0	2022	Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-kappaB/Nrf2.	3-methylquercetin	25-37	NLR family, pyrin domain containing 3	Mus musculus	103-108
35359022-0	2022	Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-kappaB/Nrf2.	3-methylquercetin	25-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	109-118
35359022-0	2022	Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3/NF-kappaB/Nrf2.	3-methylquercetin	25-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	glutamic pyruvic transaminase, soluble	Mus musculus	83-86
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	alopecia, recessive	Mus musculus	88-91
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	transmembrane protease, serine 11d	Mus musculus	97-100
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	interleukin 6	Mus musculus	141-145
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	tumor necrosis factor	Mus musculus	147-155
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	NLR family, pyrin domain containing 3	Mus musculus	164-169
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	caspase 1	Mus musculus	171-180
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	myeloperoxidase	Mus musculus	186-189
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	sirtuin 1	Mus musculus	250-259
35359022-7	2022	Isorhamnetin at the higher dose of 100 mg/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNFalpha, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2.	3-methylquercetin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	265-269
35306954-0	2022	Isorhamnetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting mTOR signaling pathway.	3-methylquercetin	0-12	mechanistic target of rapamycin kinase	Mus musculus	83-87
35306954-3	2022	Our previous study has shown that ISO could attenuate lipopolysaccharide (LPS)-induced acute lung injury in mice, but its mechanism is not clear.Methods: In this study, we used LPS-induced mouse and cell models to research the mechanism of ISO alleviating acute lung injury.Results: The results showed that ISO could attenuate the injury of type II alveolar epithelial cells by inhibiting the TLR4/NF-kappaB pathway.	3-methylquercetin	34-37	toll-like receptor 4	Mus musculus	393-397
35306954-3	2022	Our previous study has shown that ISO could attenuate lipopolysaccharide (LPS)-induced acute lung injury in mice, but its mechanism is not clear.Methods: In this study, we used LPS-induced mouse and cell models to research the mechanism of ISO alleviating acute lung injury.Results: The results showed that ISO could attenuate the injury of type II alveolar epithelial cells by inhibiting the TLR4/NF-kappaB pathway.	3-methylquercetin	34-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	398-407
35306954-4	2022	Further studies showed that ISO could inhibit the activation of mTOR signal in vivo and in vitro and promote autophagy in alveolar epithelial cells to reduce lung injury caused by LPS.	3-methylquercetin	28-31	mechanistic target of rapamycin kinase	Mus musculus	64-68
35306954-5	2022	In addition, ISO could inhibit LPS-induced epithelial cell apoptosis.Conclusion: Overall, ISO could suppress injury and apoptosis of epithelial cells and activate autophagy to protect epithelial cells via inhibiting mTOR signal and attenuating LPS-induced acute lung injury in mice.	3-methylquercetin	90-93	mechanistic target of rapamycin kinase	Mus musculus	216-220
35359022-9	2022	These findings show protective effect of isorhamnetin against acetaminophen-induced liver injury through reducing oxidative stress, inflammation, and pyroptosis which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1.	3-methylquercetin	41-53	nuclear factor, erythroid derived 2, like 2	Mus musculus	209-213
35359022-9	2022	These findings show protective effect of isorhamnetin against acetaminophen-induced liver injury through reducing oxidative stress, inflammation, and pyroptosis which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1.	3-methylquercetin	41-53	NLR family, pyrin domain containing 3	Mus musculus	215-220
35359022-9	2022	These findings show protective effect of isorhamnetin against acetaminophen-induced liver injury through reducing oxidative stress, inflammation, and pyroptosis which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1.	3-methylquercetin	41-53	sirtuin 1	Mus musculus	226-235
35559247-12	2022	Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR.	3-methylquercetin	85-97	epidermal growth factor receptor	Rattus norvegicus	141-145
35559247-12	2022	Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR.	3-methylquercetin	85-97	insulin-like growth factor 1 receptor	Rattus norvegicus	147-152
35559247-12	2022	Molecular docking results showed that Diosgenin, Kaempferol, Quercetin, Hederagenin, Isorhamnetin may act on the related pathways by docking EGFR, IGF1R and INSR.	3-methylquercetin	85-97	insulin receptor	Rattus norvegicus	157-161
35502176-7	2022	The network analysis uncovered that naringenin, isorhamnetin, and taxifolin might be the compounds in DO that are mainly in charge of its roles in hyperlipidemia and might play a role by modulating the targets (including PPARG, ADIPOQ, AKT1, TNF, and APOB).	3-methylquercetin	48-60	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	221-226
35024051-13	2022	The docking results indicated that five main compounds (arachidonic acid, isorhamnetin, quercetin, kaempferol, and (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) had good binding activity with EGFR and AKT1 targets.	3-methylquercetin	74-86	epidermal growth factor receptor	Homo sapiens	199-203
35401244-0	2022	Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD.	3-methylquercetin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	62-66
35401244-0	2022	Isorhamnetin Alleviates Airway Inflammation by Regulating the Nrf2/Keap1 Pathway in a Mouse Model of COPD.	3-methylquercetin	0-12	kelch-like ECH-associated protein 1	Mus musculus	67-72
35401244-5	2022	Our results illustrated that Iso treatment significantly reduced leukocyte recruitment and excessive secretion of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation, normal T-cell expressed and secreted (RANTES) in BALF of CS-induced COPD mice in a dose-dependent manner.	3-methylquercetin	29-32	interleukin 6	Mus musculus	114-127
35401244-5	2022	Our results illustrated that Iso treatment significantly reduced leukocyte recruitment and excessive secretion of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation, normal T-cell expressed and secreted (RANTES) in BALF of CS-induced COPD mice in a dose-dependent manner.	3-methylquercetin	29-32	interleukin 6	Mus musculus	129-133
35401244-5	2022	Our results illustrated that Iso treatment significantly reduced leukocyte recruitment and excessive secretion of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation, normal T-cell expressed and secreted (RANTES) in BALF of CS-induced COPD mice in a dose-dependent manner.	3-methylquercetin	29-32	chemokine (C-C motif) ligand 2	Mus musculus	136-170
35401244-5	2022	Our results illustrated that Iso treatment significantly reduced leukocyte recruitment and excessive secretion of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation, normal T-cell expressed and secreted (RANTES) in BALF of CS-induced COPD mice in a dose-dependent manner.	3-methylquercetin	29-32	chemokine (C-C motif) ligand 2	Mus musculus	172-177
35401244-5	2022	Our results illustrated that Iso treatment significantly reduced leukocyte recruitment and excessive secretion of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation, normal T-cell expressed and secreted (RANTES) in BALF of CS-induced COPD mice in a dose-dependent manner.	3-methylquercetin	29-32	chemokine (C-C motif) ligand 5	Mus musculus	184-247
35401244-5	2022	Our results illustrated that Iso treatment significantly reduced leukocyte recruitment and excessive secretion of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), and regulated upon activation, normal T-cell expressed and secreted (RANTES) in BALF of CS-induced COPD mice in a dose-dependent manner.	3-methylquercetin	29-32	chemokine (C-C motif) ligand 5	Mus musculus	249-255
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	kelch-like ECH-associated protein 1	Mus musculus	33-38
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	nucleoporin 62	Mus musculus	65-68
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	93-134
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	heme oxygenase 1	Mus musculus	208-224
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	heme oxygenase 1	Mus musculus	226-230
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	superoxide dismutase 1, soluble	Mus musculus	233-261
35401244-8	2022	Mechanistically, Iso may degrade Keap1 through ubiquitination of p62, thereby activating the nuclear factor erythroid 2-related factor (Nrf2) pathway to increase the expression of protective factors, such as heme oxygenase-1 (HO-1), superoxide dismutase (SOD) 1, and SOD2, in lungs of CS-exposed mice, which plays an anti-inflammatory role in COPD.	3-methylquercetin	17-20	superoxide dismutase 2, mitochondrial	Mus musculus	267-271
35401244-9	2022	In conclusion, our study indicates that Iso significantly alleviates the inflammatory response in CS-induced COPD mice mainly by affecting the Nrf2/Keap1 pathway.	3-methylquercetin	40-43	nuclear factor, erythroid derived 2, like 2	Mus musculus	143-147
35401244-9	2022	In conclusion, our study indicates that Iso significantly alleviates the inflammatory response in CS-induced COPD mice mainly by affecting the Nrf2/Keap1 pathway.	3-methylquercetin	40-43	kelch-like ECH-associated protein 1	Mus musculus	148-153
35337106-11	2022	Enzyme inhibition assays revealed that hypericin, rosmarinic acid, isorhamnetin, and luteolin inhibited Mpro of SARS-CoV-2, while hypericin and isorhamnetin inhibited Mpro of SARS-CoV-1; hypericin showed inhibitory effects toward Mpro of MERS-CoV.	3-methylquercetin	67-79	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	104-108
35337106-11	2022	Enzyme inhibition assays revealed that hypericin, rosmarinic acid, isorhamnetin, and luteolin inhibited Mpro of SARS-CoV-2, while hypericin and isorhamnetin inhibited Mpro of SARS-CoV-1; hypericin showed inhibitory effects toward Mpro of MERS-CoV.	3-methylquercetin	67-79	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	167-171
35337106-11	2022	Enzyme inhibition assays revealed that hypericin, rosmarinic acid, isorhamnetin, and luteolin inhibited Mpro of SARS-CoV-2, while hypericin and isorhamnetin inhibited Mpro of SARS-CoV-1; hypericin showed inhibitory effects toward Mpro of MERS-CoV.	3-methylquercetin	67-79	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	230-234
35337106-11	2022	Enzyme inhibition assays revealed that hypericin, rosmarinic acid, isorhamnetin, and luteolin inhibited Mpro of SARS-CoV-2, while hypericin and isorhamnetin inhibited Mpro of SARS-CoV-1; hypericin showed inhibitory effects toward Mpro of MERS-CoV.	3-methylquercetin	144-156	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	167-171
35337106-11	2022	Enzyme inhibition assays revealed that hypericin, rosmarinic acid, isorhamnetin, and luteolin inhibited Mpro of SARS-CoV-2, while hypericin and isorhamnetin inhibited Mpro of SARS-CoV-1; hypericin showed inhibitory effects toward Mpro of MERS-CoV.	3-methylquercetin	144-156	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	230-234
35337106-15	2022	Moreover, isorhamnetin showed inhibitory effects toward SARS-CoV-2 and SARS-CoV-1 Mpro, indicating that this compound may have some pan-coronaviral potential.	3-methylquercetin	10-22	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	82-86
35270118-8	2022	A study of molecular docking and molecular dynamic (MD) simulation of IR3G and its aglycone isorhamnetin (IR) against human acetylcholine esterase (AChE), monoamine oxidase B (MAO-B), and Polo-like kinase-2 (PLK2) was performed and further outlined a putative mechanism in modulating neurodegenerative diseases such as PD.	3-methylquercetin	92-104	monoamine oxidase B	Homo sapiens	155-174
35270118-8	2022	A study of molecular docking and molecular dynamic (MD) simulation of IR3G and its aglycone isorhamnetin (IR) against human acetylcholine esterase (AChE), monoamine oxidase B (MAO-B), and Polo-like kinase-2 (PLK2) was performed and further outlined a putative mechanism in modulating neurodegenerative diseases such as PD.	3-methylquercetin	92-104	monoamine oxidase B	Homo sapiens	176-181
35270118-8	2022	A study of molecular docking and molecular dynamic (MD) simulation of IR3G and its aglycone isorhamnetin (IR) against human acetylcholine esterase (AChE), monoamine oxidase B (MAO-B), and Polo-like kinase-2 (PLK2) was performed and further outlined a putative mechanism in modulating neurodegenerative diseases such as PD.	3-methylquercetin	92-104	polo like kinase 2	Homo sapiens	188-206
35270118-8	2022	A study of molecular docking and molecular dynamic (MD) simulation of IR3G and its aglycone isorhamnetin (IR) against human acetylcholine esterase (AChE), monoamine oxidase B (MAO-B), and Polo-like kinase-2 (PLK2) was performed and further outlined a putative mechanism in modulating neurodegenerative diseases such as PD.	3-methylquercetin	92-104	polo like kinase 2	Homo sapiens	208-212
35024051-13	2022	The docking results indicated that five main compounds (arachidonic acid, isorhamnetin, quercetin, kaempferol, and (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) had good binding activity with EGFR and AKT1 targets.	3-methylquercetin	74-86	AKT serine/threonine kinase 1	Homo sapiens	208-212
35165507-4	2022	Network pharmacology analysis showed that acacetin, wogonin, and isorhamnetin were the main active ingredients of JFBDS, and EGFR, PIK3CA, LCK, MAPK1, MAPK3, MAPK8, STAT3, TNF, IL2, and RELA were speculated to be crucial therapeutic targets.	3-methylquercetin	65-77	mitogen-activated protein kinase 3	Homo sapiens	151-156
33847382-0	2021	Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.	3-methylquercetin	32-44	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	64-69
3029432-3	1987	In this paper, we show that when cells are infected with poliovirus in the presence of guanidine or 3-methylquercetin, both inhibitors of poliovirus replication, complete cleavage of p220 occurs by 3.5 h postinfection.	3-methylquercetin	100-117	nuclear protein, coactivator of histone transcription	Homo sapiens	183-187
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	3-methylquercetin	0-12	thymoma viral proto-oncogene 1	Mus musculus	173-176
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	3-methylquercetin	0-12	sirtuin 1	Mus musculus	177-182
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	3-methylquercetin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	183-187
33999329-0	2021	Isorhamnetin Alleviates High Glucose-Aggravated Inflammatory Response and Apoptosis in Oxygen-Glucose Deprivation and Reoxygenation-Induced HT22 Hippocampal Neurons Through Akt/SIRT1/Nrf2/HO-1 Signaling Pathway.	3-methylquercetin	0-12	heme oxygenase 1	Mus musculus	188-192
33999329-9	2021	Isorhamnetin alleviated the HG-aggravated OGD/R injury in HT22 cells through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	0-12	thymoma viral proto-oncogene 1	Mus musculus	77-80
33999329-9	2021	Isorhamnetin alleviated the HG-aggravated OGD/R injury in HT22 cells through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	0-12	sirtuin 1	Mus musculus	81-86
33999329-9	2021	Isorhamnetin alleviated the HG-aggravated OGD/R injury in HT22 cells through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-91
33999329-9	2021	Isorhamnetin alleviated the HG-aggravated OGD/R injury in HT22 cells through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	0-12	heme oxygenase 1	Mus musculus	92-96
33999329-10	2021	Meanwhile, treatment with Akt inhibitor LY294002 reversed the protective effects of isorhamnetin against HG-aggravated OGD/R injury in HT22 cells.	3-methylquercetin	84-96	thymoma viral proto-oncogene 1	Mus musculus	26-29
33999329-11	2021	In a conclusion, Isorhamnetin alleviates HG-aggravated OGD/R in HT22 hippocampal neurons through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	17-29	thymoma viral proto-oncogene 1	Mus musculus	97-100
33999329-11	2021	In a conclusion, Isorhamnetin alleviates HG-aggravated OGD/R in HT22 hippocampal neurons through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	17-29	sirtuin 1	Mus musculus	101-106
33999329-11	2021	In a conclusion, Isorhamnetin alleviates HG-aggravated OGD/R in HT22 hippocampal neurons through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	17-29	nuclear factor, erythroid derived 2, like 2	Mus musculus	107-111
33999329-11	2021	In a conclusion, Isorhamnetin alleviates HG-aggravated OGD/R in HT22 hippocampal neurons through Akt/SIRT1/Nrf2/HO-1 signaling pathway.	3-methylquercetin	17-29	heme oxygenase 1	Mus musculus	112-116
33682294-6	2021	Daidzein/quercetin and isorhamnetin/formononetin had the highest binding affinity for HER2 and PD-L1, with Kd values of 3.7 mumol/L and 490, 667, and 355 nmol/L, respectively.	3-methylquercetin	23-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90
33682294-6	2021	Daidzein/quercetin and isorhamnetin/formononetin had the highest binding affinity for HER2 and PD-L1, with Kd values of 3.7 mumol/L and 490, 667, and 355 nmol/L, respectively.	3-methylquercetin	23-35	CD274 molecule	Homo sapiens	95-100
33682294-7	2021	Molecular dynamics simulation studies based on the docking complex structures as the initial conformation yielded the binding free energy between daidzein/quercetin with HER2 and isorhamnetin/formononetin with PD-L1, calculated by molecular mechanics Poisson-Boltzmann surface area, of -26.55, -14.18, -19.41, and -11.86 kcal/mol, respectively, and were consistent with the MST results.	3-methylquercetin	179-191	CD274 molecule	Homo sapiens	210-215
34741692-0	2022	Correction to: Isorhamnetin protects against cardiac hypertrophy through blocking PI3K-AKT pathway.	3-methylquercetin	15-27	AKT serine/threonine kinase 1	Homo sapiens	87-90
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	3-methylquercetin	86-98	vascular endothelial growth factor A	Homo sapiens	152-157
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	3-methylquercetin	86-98	interleukin 6	Homo sapiens	159-162
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	3-methylquercetin	86-98	tumor necrosis factor	Homo sapiens	164-167
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	3-methylquercetin	86-98	tumor protein p53	Homo sapiens	179-183
34035828-9	2021	Further analysis showed that the HGD activity of quercetin, formononetin, kaempferol, isorhamnetin, and beta-sitosterol ingredients is possible through VEGFA, IL6, TNF, AKT1, and TP53 targets involved in TNF, toll-like receptors, and MAPK-related pathways, which have anti-inflammatory, antiapoptosis, antioxidation, and autophagy effects, relieve renal fibrosis and renal cortex injury, and improve renal function, thus delaying the development of DN.	3-methylquercetin	86-98	tumor necrosis factor	Homo sapiens	204-207
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	3-methylquercetin	79-91	vascular endothelial growth factor A	Homo sapiens	142-147
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	3-methylquercetin	79-91	interleukin 6	Homo sapiens	149-152
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	3-methylquercetin	79-91	tumor necrosis factor	Homo sapiens	154-157
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	3-methylquercetin	79-91	AKT serine/threonine kinase 1	Homo sapiens	159-163
34035828-10	2021	The molecular docking results showed that quercetin, formononetin, kaempferol, isorhamnetin, beta-sitosterol had a good binding activity with VEGFA, IL6, TNF, AKT1, and TP53.	3-methylquercetin	79-91	tumor protein p53	Homo sapiens	169-173
33847382-4	2021	In this study, we observed that seabuckthorn and its flavonoid compounds quercetin and isorhamnetin were shown strong retention to ACE2 overexpression HEK293 (ACE2h ) cells by CMC analysis.	3-methylquercetin	87-99	angiotensin converting enzyme 2	Homo sapiens	131-135
33847382-6	2021	Surface plasmon resonance assay proved the effect that isorhamnetin bound to the ACE2, and its affinity (KD value) was at the micromolar level, that was, 2.51 +- 0.68 muM.	3-methylquercetin	55-67	angiotensin converting enzyme 2	Homo sapiens	81-85
33847382-7	2021	Viral entry studies in vitro indicated that isorhamnetin inhibited SARS-CoV-2 spike pseudotyped virus entering ACE2h cells.	3-methylquercetin	44-56	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	78-83
33847382-7	2021	Viral entry studies in vitro indicated that isorhamnetin inhibited SARS-CoV-2 spike pseudotyped virus entering ACE2h cells.	3-methylquercetin	44-56	angiotensin converting enzyme 2	Homo sapiens	111-115
33921231-0	2021	Isorhamnetin Ameliorates Dry Eye Disease via CFTR Activation in Mice.	3-methylquercetin	0-12	cystic fibrosis transmembrane conductance regulator	Mus musculus	45-49
33921231-4	2021	Screening of 1000 natural products revealed isorhamnetin, a flavonol aglycone, as a novel CFTR activator.	3-methylquercetin	44-56	cystic fibrosis transmembrane conductance regulator	Mus musculus	90-94
33921231-5	2021	Electrophysiological studies showed that isorhamnetin significantly increased CFTR chloride current, both wild type and  F508-CFTR.	3-methylquercetin	41-53	cystic fibrosis transmembrane conductance regulator	Mus musculus	78-82
33921231-5	2021	Electrophysiological studies showed that isorhamnetin significantly increased CFTR chloride current, both wild type and  F508-CFTR.	3-methylquercetin	41-53	cystic fibrosis transmembrane conductance regulator	Mus musculus	126-130
33921231-7	2021	Notably, application of isorhamnetin on mouse ocular surface induced CFTR activation and increased tear volume.	3-methylquercetin	24-36	cystic fibrosis transmembrane conductance regulator	Mus musculus	69-73
33921231-8	2021	In addition, isorhamnetin significantly reduced ocular surface damage and expression of interleukin (IL)-1beta, IL-8, and tumor necrosis factor (TNF)-alpha in an experimental mouse model of dry eye.	3-methylquercetin	13-25	interleukin 1 alpha	Mus musculus	88-110
33921231-8	2021	In addition, isorhamnetin significantly reduced ocular surface damage and expression of interleukin (IL)-1beta, IL-8, and tumor necrosis factor (TNF)-alpha in an experimental mouse model of dry eye.	3-methylquercetin	13-25	chemokine (C-X-C motif) ligand 15	Mus musculus	112-116
33921231-8	2021	In addition, isorhamnetin significantly reduced ocular surface damage and expression of interleukin (IL)-1beta, IL-8, and tumor necrosis factor (TNF)-alpha in an experimental mouse model of dry eye.	3-methylquercetin	13-25	tumor necrosis factor	Mus musculus	122-155
32865318-0	2021	Isorhamnetin attenuates TNF-alpha-induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF-kappaB pathways.	3-methylquercetin	0-12	tumor necrosis factor	Homo sapiens	24-33
32865318-0	2021	Isorhamnetin attenuates TNF-alpha-induced inflammation, proliferation, and migration in human bronchial epithelial cells via MAPK and NF-kappaB pathways.	3-methylquercetin	0-12	nuclear factor kappa B subunit 1	Homo sapiens	134-143
32865318-11	2021	We found that isorhamnetin at 20 and 40 muM reduced the proliferation of BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	14-26	tumor necrosis factor	Homo sapiens	98-107
32865318-12	2021	Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	0-12	interleukin 1 alpha	Homo sapiens	55-77
32865318-12	2021	Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	0-12	interleukin 6	Homo sapiens	79-83
32865318-12	2021	Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
32865318-12	2021	Isorhamnetin significantly decreased the expression of interleukin (IL)-1beta, IL-6, IL-8, and C-X-C motif chemokine ligand 10 in BEAS-2B cells induced by TNF-alpha.	3-methylquercetin	0-12	tumor necrosis factor	Homo sapiens	155-164
32865318-13	2021	Additionally, 10 muM isorhamnetin effectively reduced cell migration induced by TNF-alpha.	3-methylquercetin	21-33	tumor necrosis factor	Homo sapiens	80-89
32865318-14	2021	Treatment with isorhamnetin inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and NF-kappaB pathways induced by TNF-alpha.	3-methylquercetin	15-27	nuclear factor kappa B subunit 1	Homo sapiens	105-114
32865318-14	2021	Treatment with isorhamnetin inhibited the phosphorylation of mitogen-activated protein kinase (MAPK) and NF-kappaB pathways induced by TNF-alpha.	3-methylquercetin	15-27	tumor necrosis factor	Homo sapiens	135-144
32865318-15	2021	In summary, isorhamnetin inhibited the inflammation, proliferation, and migration of BEAS-2B cells by regulating the MAPK and NF-kappaB signalling pathways and is a drug candidate for asthma.	3-methylquercetin	12-24	nuclear factor kappa B subunit 1	Homo sapiens	126-135
33732368-0	2021	Salidroside and isorhamnetin attenuate urotensin II-induced inflammatory response in vivo and in vitro: Involvement in regulating the RhoA/ROCK II pathway.	3-methylquercetin	16-28	urotensin 2	Rattus norvegicus	39-51
33732368-0	2021	Salidroside and isorhamnetin attenuate urotensin II-induced inflammatory response in vivo and in vitro: Involvement in regulating the RhoA/ROCK II pathway.	3-methylquercetin	16-28	ras homolog family member A	Rattus norvegicus	134-138
33732368-0	2021	Salidroside and isorhamnetin attenuate urotensin II-induced inflammatory response in vivo and in vitro: Involvement in regulating the RhoA/ROCK II pathway.	3-methylquercetin	16-28	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	139-146
33732368-8	2021	It was demonstrated that salidroside, isorhamnetin and both in combination decreased the levels of the serum pro-inflammatory cytokines TNF-alpha and IL-1beta, as well as increased the levels of the anti-inflammatory cytokine IL-10 and macrophage migration inhibitory factor in rats with subacute infusion of UII and in the culture supernatant from primary VSMCs-exposed to UII.	3-methylquercetin	38-50	tumor necrosis factor	Rattus norvegicus	136-145
33732368-8	2021	It was demonstrated that salidroside, isorhamnetin and both in combination decreased the levels of the serum pro-inflammatory cytokines TNF-alpha and IL-1beta, as well as increased the levels of the anti-inflammatory cytokine IL-10 and macrophage migration inhibitory factor in rats with subacute infusion of UII and in the culture supernatant from primary VSMCs-exposed to UII.	3-methylquercetin	38-50	interleukin 1 alpha	Rattus norvegicus	150-158
33732368-8	2021	It was demonstrated that salidroside, isorhamnetin and both in combination decreased the levels of the serum pro-inflammatory cytokines TNF-alpha and IL-1beta, as well as increased the levels of the anti-inflammatory cytokine IL-10 and macrophage migration inhibitory factor in rats with subacute infusion of UII and in the culture supernatant from primary VSMCs-exposed to UII.	3-methylquercetin	38-50	interleukin 10	Rattus norvegicus	226-231
33732368-8	2021	It was demonstrated that salidroside, isorhamnetin and both in combination decreased the levels of the serum pro-inflammatory cytokines TNF-alpha and IL-1beta, as well as increased the levels of the anti-inflammatory cytokine IL-10 and macrophage migration inhibitory factor in rats with subacute infusion of UII and in the culture supernatant from primary VSMCs-exposed to UII.	3-methylquercetin	38-50	macrophage migration inhibitory factor	Rattus norvegicus	236-274
33732368-9	2021	Moreover, salidroside, isorhamnetin and both in combination attenuated the mRNA and protein expression levels of RhoA and ROCK II in vivo and in vitro, at concentrations corresponding to human therapeutic blood plasma concentrations.	3-methylquercetin	23-35	ras homolog family member A	Homo sapiens	113-117
33732368-9	2021	Moreover, salidroside, isorhamnetin and both in combination attenuated the mRNA and protein expression levels of RhoA and ROCK II in vivo and in vitro, at concentrations corresponding to human therapeutic blood plasma concentrations.	3-methylquercetin	23-35	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	122-129
33732368-12	2021	Collectively, the results indicated that salidroside, isorhamnetin and both in combination inhibited the RhoA/ROCK II pathway, which then attenuated the inflammatory response under UII-induced conditions, resulting in cardioprotection in atherosclerosis.	3-methylquercetin	54-66	ras homolog family member A	Homo sapiens	105-109
33732368-12	2021	Collectively, the results indicated that salidroside, isorhamnetin and both in combination inhibited the RhoA/ROCK II pathway, which then attenuated the inflammatory response under UII-induced conditions, resulting in cardioprotection in atherosclerosis.	3-methylquercetin	54-66	Rho associated coiled-coil containing protein kinase 2	Homo sapiens	110-117
33719855-5	2021	Three flavonoids isorhamnetin (1), kaempferol (2) and apigenin (3) showed good binding affinity, stable protein-ligand complexes throughout the simulation time, high binding energy and similar binding poses in comparison with known SARS-CoV-2 Mpro inhibitor baicalein.	3-methylquercetin	17-29	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	243-247
33453223-6	2021	ISO treatment activated nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and abated oxidative stress in injured spinal cords.	3-methylquercetin	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	24-67
33453223-6	2021	ISO treatment activated nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and abated oxidative stress in injured spinal cords.	3-methylquercetin	0-3	NFE2 like bZIP transcription factor 2	Rattus norvegicus	69-73
33453223-6	2021	ISO treatment activated nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and abated oxidative stress in injured spinal cords.	3-methylquercetin	0-3	heme oxygenase 1	Rattus norvegicus	75-91
33453223-6	2021	ISO treatment activated nuclear factor-erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and abated oxidative stress in injured spinal cords.	3-methylquercetin	0-3	heme oxygenase 1	Rattus norvegicus	93-97
33453223-7	2021	ISO treatment partly suppressed microglial and glial activation and reduced expression of inflammatory cytokines including TNF-alpha, monocyte chemotactic protein-1 (MCP-1), and IL-1beta in injured spinal cords.	3-methylquercetin	0-3	tumor necrosis factor	Rattus norvegicus	123-132
33453223-7	2021	ISO treatment partly suppressed microglial and glial activation and reduced expression of inflammatory cytokines including TNF-alpha, monocyte chemotactic protein-1 (MCP-1), and IL-1beta in injured spinal cords.	3-methylquercetin	0-3	C-C motif chemokine ligand 2	Rattus norvegicus	134-164
33453223-7	2021	ISO treatment partly suppressed microglial and glial activation and reduced expression of inflammatory cytokines including TNF-alpha, monocyte chemotactic protein-1 (MCP-1), and IL-1beta in injured spinal cords.	3-methylquercetin	0-3	C-C motif chemokine ligand 2	Rattus norvegicus	166-171
33453223-7	2021	ISO treatment partly suppressed microglial and glial activation and reduced expression of inflammatory cytokines including TNF-alpha, monocyte chemotactic protein-1 (MCP-1), and IL-1beta in injured spinal cords.	3-methylquercetin	0-3	interleukin 1 alpha	Rattus norvegicus	178-186
32654232-0	2021	Isorhamnetin induces the paraptotic cell death through ROS and the ERK/MAPK pathway in OSCC cells.	3-methylquercetin	0-12	mitogen-activated protein kinase 1	Homo sapiens	67-70
32654232-10	2021	Isorhamnetin was observed to upregulate phosphorylated ERK cascades and increase ROS levels.	3-methylquercetin	0-12	mitogen-activated protein kinase 1	Homo sapiens	55-58
33569004-0	2020	Isorhamnetin Enhances the Radiosensitivity of A549 Cells Through Interleukin-13 and the NF-kappaB Signaling Pathway.	3-methylquercetin	0-12	interleukin 13	Homo sapiens	65-79
33679411-0	2021	Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	90-93
33679411-7	2021	Isorhamnetin was found to suppress cell proliferation and metastasis, and trigger apoptosis and arrest the G2/M phase in GBC cells via the inactivation of the PI3K/AKT signaling cascade.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	164-167
33569004-0	2020	Isorhamnetin Enhances the Radiosensitivity of A549 Cells Through Interleukin-13 and the NF-kappaB Signaling Pathway.	3-methylquercetin	0-12	nuclear factor kappa B subunit 1	Homo sapiens	88-97
33569004-5	2020	In addition, ISO pretreatment significantly enhanced the radiation-induced incidence of apoptosis, the collapse of mitochondrial membrane potential, and the expressions of proteins associated with cellular apoptosis and suppressed the upregulation of NF-kappaBp65 induced by irradiation in A549 cells.	3-methylquercetin	13-16	RELA proto-oncogene, NF-kB subunit	Homo sapiens	251-263
33569004-7	2020	The knockdown of IL-13 expression by RNA interference decreased the IL-13 level and thus reduced ISO-mediated radiosensitivity in cells.	3-methylquercetin	97-100	interleukin 13	Homo sapiens	17-22
33569004-8	2020	We also found that the IR-induced NF-kappaB signaling activation was inhibited by ISO pretreatment, and it was abrogated in IL-13 silenced cells.	3-methylquercetin	82-85	nuclear factor kappa B subunit 1	Homo sapiens	34-43
33569004-9	2020	We speculated that ISO may confer radiosensitivity on A549 cells via increasing the expression of IL-13 and inhibiting the activation of NF-kappaB.	3-methylquercetin	19-22	interleukin 13	Homo sapiens	98-103
33569004-9	2020	We speculated that ISO may confer radiosensitivity on A549 cells via increasing the expression of IL-13 and inhibiting the activation of NF-kappaB.	3-methylquercetin	19-22	nuclear factor kappa B subunit 1	Homo sapiens	137-146
33569004-10	2020	To our knowledge, this is the first report demonstrating the effects of ISO treatment on the responsiveness of lung cancer cells to irradiation through IL-13 and the NF-kappaB signaling pathway.	3-methylquercetin	72-75	interleukin 13	Homo sapiens	152-157
33569004-10	2020	To our knowledge, this is the first report demonstrating the effects of ISO treatment on the responsiveness of lung cancer cells to irradiation through IL-13 and the NF-kappaB signaling pathway.	3-methylquercetin	72-75	nuclear factor kappa B subunit 1	Homo sapiens	166-175
32706197-6	2020	Our results support the finding that isorhamnetin enhanced the antioxidant effect induced by 1-Methyl-4-phenylpyridine in PC12 cells by suppressing the activation of the PI3K/Akt signaling pathway.	3-methylquercetin	37-49	AKT serine/threonine kinase 1	Rattus norvegicus	175-178
32781171-5	2020	Computational analysis indicates that CAPE, daidzein, isorhamnetin and genistein can bind inside the DNA substrate-binding site in human DNMT1 with a favorable binding energy.	3-methylquercetin	54-66	DNA methyltransferase 1	Homo sapiens	137-142
33224947-9	2020	Hepatic progenitor markers, EPCAM and DLK1, were upregulated in the isorhamnetin-treated hAECs.	3-methylquercetin	68-80	epithelial cell adhesion molecule	Homo sapiens	28-33
33224947-9	2020	Hepatic progenitor markers, EPCAM and DLK1, were upregulated in the isorhamnetin-treated hAECs.	3-methylquercetin	68-80	delta like non-canonical Notch ligand 1	Homo sapiens	38-42
33224947-11	2020	Furthermore, isorhamnetin-treated cells could show increased CYP enzyme mRNA levels, ICG uptake and release, glycogen storage activity, and urea secretion.	3-methylquercetin	13-25	peptidylprolyl isomerase G	Homo sapiens	61-64
32452118-9	2020	In vitro, isorhamnetin suppressed TNF-alpha-induced HPASMCs proliferation.	3-methylquercetin	10-22	tumor necrosis factor	Rattus norvegicus	34-43
32452118-10	2020	Furthermore, isorhamnetin improved protein expression of BMPR2 and suppressed protein expression of TNF-alpha and IL-6 in rat lungs.	3-methylquercetin	13-25	bone morphogenetic protein receptor type 2	Rattus norvegicus	57-62
32452118-10	2020	Furthermore, isorhamnetin improved protein expression of BMPR2 and suppressed protein expression of TNF-alpha and IL-6 in rat lungs.	3-methylquercetin	13-25	tumor necrosis factor	Rattus norvegicus	100-109
32452118-10	2020	Furthermore, isorhamnetin improved protein expression of BMPR2 and suppressed protein expression of TNF-alpha and IL-6 in rat lungs.	3-methylquercetin	13-25	interleukin 6	Rattus norvegicus	114-118
32452118-11	2020	Isorhamnetin improved protein expression of BMPR2 and p-smad1/5 and mRNA expression of Id1 and Id3 in HPASMCs.	3-methylquercetin	0-12	bone morphogenetic protein receptor type 2	Rattus norvegicus	44-49
32452118-11	2020	Isorhamnetin improved protein expression of BMPR2 and p-smad1/5 and mRNA expression of Id1 and Id3 in HPASMCs.	3-methylquercetin	0-12	SMAD family member 1	Rattus norvegicus	56-63
32452118-11	2020	Isorhamnetin improved protein expression of BMPR2 and p-smad1/5 and mRNA expression of Id1 and Id3 in HPASMCs.	3-methylquercetin	0-12	inhibitor of DNA binding 1, HLH protein	Rattus norvegicus	87-90
32452118-11	2020	Isorhamnetin improved protein expression of BMPR2 and p-smad1/5 and mRNA expression of Id1 and Id3 in HPASMCs.	3-methylquercetin	0-12	inhibitor of DNA binding 3, HLH protein	Rattus norvegicus	95-98
32452118-12	2020	Isorhamnetin ameliorated MCT-induced PAH in rats and inhibited TNF-alpha-induced HPASMCs proliferation by a mechanism likely involving the regulation of the BMP signaling pathway.	3-methylquercetin	0-12	tumor necrosis factor	Rattus norvegicus	63-72
33117805-4	2020	In vitro, biological processes including TGFbeta, collagen-related functions, and inflammatory processes were significantly suppressed in ISO pretreated hAESCs.	3-methylquercetin	138-141	transforming growth factor alpha	Homo sapiens	41-48
33117805-6	2020	ISO was found to reverse the enhanced TGFbeta and Collagen type I alpha 1 mRNA expression induced by AgII exposure, which causes cardiovascular remodeling in ventricular tissue.	3-methylquercetin	0-3	transforming growth factor alpha	Homo sapiens	38-45
33117805-6	2020	ISO was found to reverse the enhanced TGFbeta and Collagen type I alpha 1 mRNA expression induced by AgII exposure, which causes cardiovascular remodeling in ventricular tissue.	3-methylquercetin	0-3	collagen type I alpha 1 chain	Homo sapiens	50-73
32766793-0	2020	Correction: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells.	3-methylquercetin	12-24	AKT serine/threonine kinase 1	Homo sapiens	77-80
32766793-0	2020	Correction: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells.	3-methylquercetin	12-24	mitogen-activated protein kinase 1	Homo sapiens	81-84
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	3-methylquercetin	81-93	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	137-142
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	3-methylquercetin	81-93	heat shock protein family A (Hsp70) member 5	Homo sapiens	176-181
33149560-8	2020	However, 4 polyphenols such as epigallocatechin gallate (EGCG), homoeriodictyol, isorhamnetin, and curcumin interact, in addition to the Spike protein and its binding sites in GRP78, with the ATPase domain of GRP78.	3-methylquercetin	81-93	heat shock protein family A (Hsp70) member 5	Homo sapiens	209-214
32602541-0	2020	Expression of Concern: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells.	3-methylquercetin	23-35	AKT serine/threonine kinase 1	Homo sapiens	88-91
32602541-0	2020	Expression of Concern: Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small cell lung cancer cells.	3-methylquercetin	23-35	mitogen-activated protein kinase 1	Homo sapiens	92-95
32046625-0	2020	Isorhamnetin, a 3"-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner.	3-methylquercetin	0-12	transcription factor EB	Mus musculus	111-115
30983153-6	2019	We demonstrated that Iso suppressed RANKL-induced ROS generation, which could mediate osteoclastogenesis.	3-methylquercetin	21-24	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	36-41
32461960-0	2020	Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-kappaB Pathways.	3-methylquercetin	0-12	thymoma viral proto-oncogene 1	Mus musculus	58-61
32461960-0	2020	Isorhamnetin Induces Melanoma Cell Apoptosis via the PI3K/Akt and NF-kappaB Pathways.	3-methylquercetin	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
32039440-0	2020	Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	172-175
32039440-0	2020	Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway.	3-methylquercetin	0-12	mechanistic target of rapamycin kinase	Homo sapiens	176-180
32039440-3	2020	Furthermore, Isorhamnetin inhibited cell migration and invasion in concentration-dependent manners by enhancing mesenchymal-epithelial transition (MET) and inhibiting MMP-2 and MMP-9 overexpression.	3-methylquercetin	13-25	matrix metallopeptidase 2	Homo sapiens	167-172
32039440-3	2020	Furthermore, Isorhamnetin inhibited cell migration and invasion in concentration-dependent manners by enhancing mesenchymal-epithelial transition (MET) and inhibiting MMP-2 and MMP-9 overexpression.	3-methylquercetin	13-25	matrix metallopeptidase 9	Homo sapiens	177-182
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Homo sapiens	94-97
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Homo sapiens	99-104
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	111-115
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	117-123
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Homo sapiens	101-104
32039440-4	2020	In addition, Isorhamnetin also down-regulated the expression of phosphorylated PI3K (p-P13K), Akt (p-Akt), and mTOR (p-mTOR) proteins in both cancer cells, revealing Isorhamnetin be a selective PI3K-Akt-mTOR pathway inhibitor.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	119-123
31586635-6	2019	Treatment of RE rats with isorhamnetin improved esophageal barrier function, through upregulating proteins expression of occludin and zonula occludens-1 (ZO-1) and downregulating proteins expression of matrix matalloproteinases-3 (MMP3) and -9.	3-methylquercetin	26-38	occludin	Rattus norvegicus	121-129
31586635-6	2019	Treatment of RE rats with isorhamnetin improved esophageal barrier function, through upregulating proteins expression of occludin and zonula occludens-1 (ZO-1) and downregulating proteins expression of matrix matalloproteinases-3 (MMP3) and -9.	3-methylquercetin	26-38	matrix metallopeptidase 3	Rattus norvegicus	202-243
31586635-7	2019	Administration of isorhamnetin decreased CD68-positive cells and mRNA levels of IL-6, TNF-alpha, and IL-1beta in the esophagus of RE rats.	3-methylquercetin	18-30	interleukin 6	Rattus norvegicus	80-84
31586635-7	2019	Administration of isorhamnetin decreased CD68-positive cells and mRNA levels of IL-6, TNF-alpha, and IL-1beta in the esophagus of RE rats.	3-methylquercetin	18-30	tumor necrosis factor	Rattus norvegicus	86-95
31586635-7	2019	Administration of isorhamnetin decreased CD68-positive cells and mRNA levels of IL-6, TNF-alpha, and IL-1beta in the esophagus of RE rats.	3-methylquercetin	18-30	interleukin 1 beta	Rattus norvegicus	101-109
31586635-8	2019	Administration of isorhamnetin downregulated inducible nitric oxide synthase (iNOS) protein expression and decreased production of nitric oxide (NO) and 3-nitrotyrosin in the esophagus of RE rats.	3-methylquercetin	18-30	nitric oxide synthase 2	Rattus norvegicus	45-76
31586635-8	2019	Administration of isorhamnetin downregulated inducible nitric oxide synthase (iNOS) protein expression and decreased production of nitric oxide (NO) and 3-nitrotyrosin in the esophagus of RE rats.	3-methylquercetin	18-30	nitric oxide synthase 2	Rattus norvegicus	78-82
31586635-9	2019	Administration of isorhamnetin enhanced heme oxygenase-1 (HO-1) activities and reduced malondialdehyde (MDA) levels in esophagus of RE rats.	3-methylquercetin	18-30	heme oxygenase 1	Rattus norvegicus	40-56
31586635-9	2019	Administration of isorhamnetin enhanced heme oxygenase-1 (HO-1) activities and reduced malondialdehyde (MDA) levels in esophagus of RE rats.	3-methylquercetin	18-30	heme oxygenase 1	Rattus norvegicus	58-62
31586635-10	2019	Additionally, treatment with isorhamnetin inhibited p38 MAPK and NFkappaB activation in RE esophagus.	3-methylquercetin	29-41	mitogen activated protein kinase 14	Rattus norvegicus	52-55
32914113-0	2020	Fat-lowering effects of isorhamnetin are via NHR-49-dependent pathway in Caenorhabditis elegans.	3-methylquercetin	24-36	FAT atypical cadherin 1	Homo sapiens	0-3
32914113-0	2020	Fat-lowering effects of isorhamnetin are via NHR-49-dependent pathway in Caenorhabditis elegans.	3-methylquercetin	24-36	NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49	Caenorhabditis elegans	45-51
32914113-3	2020	Isorhamnetin reduced fat accumulation without affecting food intake or energy expenditure in C. elegans.	3-methylquercetin	0-12	FAT atypical cadherin 1	Homo sapiens	21-24
32914113-4	2020	The isorhamnetin"s fat-lowering effects were dependent on nhr-49, a homolog of the human peroxisome proliferator-activated receptor alpha (PPARalpha).	3-methylquercetin	4-16	FAT atypical cadherin 1	Homo sapiens	19-22
32914113-4	2020	The isorhamnetin"s fat-lowering effects were dependent on nhr-49, a homolog of the human peroxisome proliferator-activated receptor alpha (PPARalpha).	3-methylquercetin	4-16	NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49	Caenorhabditis elegans	58-64
32914113-4	2020	The isorhamnetin"s fat-lowering effects were dependent on nhr-49, a homolog of the human peroxisome proliferator-activated receptor alpha (PPARalpha).	3-methylquercetin	4-16	peroxisome proliferator activated receptor alpha	Homo sapiens	89-137
32914113-4	2020	The isorhamnetin"s fat-lowering effects were dependent on nhr-49, a homolog of the human peroxisome proliferator-activated receptor alpha (PPARalpha).	3-methylquercetin	4-16	peroxisome proliferator activated receptor alpha	Homo sapiens	139-148
32914113-5	2020	Isorhamnetin upregulated an enoyl-CoA hydratase (ech-1.1, involved in fatty acid beta-oxidation) and adipose triglyceride lipase (atgl-1, involved in lipolysis) via NHR-49-dependent pathway at transcriptional levels.	3-methylquercetin	0-12	Enoyl-CoA Hydratase	Caenorhabditis elegans	28-47
32914113-5	2020	Isorhamnetin upregulated an enoyl-CoA hydratase (ech-1.1, involved in fatty acid beta-oxidation) and adipose triglyceride lipase (atgl-1, involved in lipolysis) via NHR-49-dependent pathway at transcriptional levels.	3-methylquercetin	0-12	Enoyl-CoA Hydratase	Caenorhabditis elegans	49-56
32914113-5	2020	Isorhamnetin upregulated an enoyl-CoA hydratase (ech-1.1, involved in fatty acid beta-oxidation) and adipose triglyceride lipase (atgl-1, involved in lipolysis) via NHR-49-dependent pathway at transcriptional levels.	3-methylquercetin	0-12	PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1	Caenorhabditis elegans	101-128
32914113-5	2020	Isorhamnetin upregulated an enoyl-CoA hydratase (ech-1.1, involved in fatty acid beta-oxidation) and adipose triglyceride lipase (atgl-1, involved in lipolysis) via NHR-49-dependent pathway at transcriptional levels.	3-methylquercetin	0-12	PNPLA domain-containing protein;Patanin-like phospholipase domain-containing protein atgl-1	Caenorhabditis elegans	130-136
32914113-5	2020	Isorhamnetin upregulated an enoyl-CoA hydratase (ech-1.1, involved in fatty acid beta-oxidation) and adipose triglyceride lipase (atgl-1, involved in lipolysis) via NHR-49-dependent pathway at transcriptional levels.	3-methylquercetin	0-12	NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49	Caenorhabditis elegans	165-171
32914113-6	2020	Isorhamnetin also upregulated the C. elegans AMP-activated protein kinase (AMPK) subunits homologs (aak-1 and aak-2), involved in energy homeostasis.	3-methylquercetin	0-12	5'-AMP-activated protein kinase catalytic subunit alpha-1	Caenorhabditis elegans	100-105
32914113-6	2020	Isorhamnetin also upregulated the C. elegans AMP-activated protein kinase (AMPK) subunits homologs (aak-1 and aak-2), involved in energy homeostasis.	3-methylquercetin	0-12	5'-AMP-activated protein kinase catalytic subunit alpha-2	Caenorhabditis elegans	110-115
32914113-7	2020	These results suggest that isorhamnetin reduces body fat by increasing fat oxidation in part via NHR-49/PPARalpha-dependent pathway.	3-methylquercetin	27-39	FAT atypical cadherin 1	Homo sapiens	53-56
32914113-7	2020	These results suggest that isorhamnetin reduces body fat by increasing fat oxidation in part via NHR-49/PPARalpha-dependent pathway.	3-methylquercetin	27-39	FAT atypical cadherin 1	Homo sapiens	71-74
32914113-7	2020	These results suggest that isorhamnetin reduces body fat by increasing fat oxidation in part via NHR-49/PPARalpha-dependent pathway.	3-methylquercetin	27-39	NR LBD domain-containing protein;Nuclear hormone receptor family member nhr-49	Caenorhabditis elegans	97-103
32914113-7	2020	These results suggest that isorhamnetin reduces body fat by increasing fat oxidation in part via NHR-49/PPARalpha-dependent pathway.	3-methylquercetin	27-39	peroxisome proliferator activated receptor alpha	Homo sapiens	104-113
31590241-4	2019	Our data showed that isorhamnetin decreased the expression of Wee1 and cyclin B1, but increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1, and increased p21 was bound to Cdk1.	3-methylquercetin	21-33	WEE1 G2 checkpoint kinase	Homo sapiens	62-66
31590241-4	2019	Our data showed that isorhamnetin decreased the expression of Wee1 and cyclin B1, but increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1, and increased p21 was bound to Cdk1.	3-methylquercetin	21-33	cyclin B1	Homo sapiens	71-80
31590241-4	2019	Our data showed that isorhamnetin decreased the expression of Wee1 and cyclin B1, but increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1, and increased p21 was bound to Cdk1.	3-methylquercetin	21-33	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-166
31590241-4	2019	Our data showed that isorhamnetin decreased the expression of Wee1 and cyclin B1, but increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1, and increased p21 was bound to Cdk1.	3-methylquercetin	21-33	cyclin dependent kinase inhibitor 1A	Homo sapiens	154-157
31590241-4	2019	Our data showed that isorhamnetin decreased the expression of Wee1 and cyclin B1, but increased the expression of cyclin-dependent kinase (Cdk) inhibitor p21WAF1/CIP1, and increased p21 was bound to Cdk1.	3-methylquercetin	21-33	cyclin dependent kinase 1	Homo sapiens	199-203
31590241-5	2019	In addition, isorhamnetin-induced apoptosis was associated with the increased expression of the Fas/Fas ligand, reduced ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax) expression, cytosolic release of cytochrome c, and activation of caspases.	3-methylquercetin	13-25	Fas ligand	Homo sapiens	100-110
31590241-5	2019	In addition, isorhamnetin-induced apoptosis was associated with the increased expression of the Fas/Fas ligand, reduced ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax) expression, cytosolic release of cytochrome c, and activation of caspases.	3-methylquercetin	13-25	BCL2 apoptosis regulator	Homo sapiens	129-146
31590241-5	2019	In addition, isorhamnetin-induced apoptosis was associated with the increased expression of the Fas/Fas ligand, reduced ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax) expression, cytosolic release of cytochrome c, and activation of caspases.	3-methylquercetin	13-25	BCL2 apoptosis regulator	Homo sapiens	148-153
31590241-5	2019	In addition, isorhamnetin-induced apoptosis was associated with the increased expression of the Fas/Fas ligand, reduced ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax) expression, cytosolic release of cytochrome c, and activation of caspases.	3-methylquercetin	13-25	BCL2 apoptosis regulator	Homo sapiens	155-160
31590241-5	2019	In addition, isorhamnetin-induced apoptosis was associated with the increased expression of the Fas/Fas ligand, reduced ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax) expression, cytosolic release of cytochrome c, and activation of caspases.	3-methylquercetin	13-25	BCL2 associated X, apoptosis regulator	Homo sapiens	183-186
31590241-5	2019	In addition, isorhamnetin-induced apoptosis was associated with the increased expression of the Fas/Fas ligand, reduced ratio of B-cell lymphoma 2 (Bcl-2)/Bcl-2 associated X protein (Bax) expression, cytosolic release of cytochrome c, and activation of caspases.	3-methylquercetin	13-25	cytochrome c, somatic	Homo sapiens	221-233
31342791-10	2019	Isorhamnetin inhibited the production of NO and PGE2, and the expression of iNOS and COX-2.	3-methylquercetin	0-12	nitric oxide synthase 2	Rattus norvegicus	76-80
31342791-10	2019	Isorhamnetin inhibited the production of NO and PGE2, and the expression of iNOS and COX-2.	3-methylquercetin	0-12	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	85-90
31367693-4	2019	Isorhamnetin and tamarixetin inhibited human platelet aggregation, and suppressed activatory processes including granule secretion, integrin alphaIIbbeta3 function, calcium mobilization, and spleen tyrosine kinase (Syk)/linker for activation of T cells (LAT) phosphorylation downstream of glycoprotein VI with similar potency to quercetin.	3-methylquercetin	0-12	spleen associated tyrosine kinase	Homo sapiens	215-218
31367693-4	2019	Isorhamnetin and tamarixetin inhibited human platelet aggregation, and suppressed activatory processes including granule secretion, integrin alphaIIbbeta3 function, calcium mobilization, and spleen tyrosine kinase (Syk)/linker for activation of T cells (LAT) phosphorylation downstream of glycoprotein VI with similar potency to quercetin.	3-methylquercetin	0-12	linker for activation of T cells	Homo sapiens	254-257
32307912-3	2020	Moreover, isorhamnetin reperfusion inhibited apoptosis of cardiomyocytes in the rats subjected to cardiac I/R in a dose-dependent manner concomitant with decreased protein expression of Bax and cleaved-caspase-3, as well as increased protein expression of Bcl-2.	3-methylquercetin	10-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	186-189
32307912-3	2020	Moreover, isorhamnetin reperfusion inhibited apoptosis of cardiomyocytes in the rats subjected to cardiac I/R in a dose-dependent manner concomitant with decreased protein expression of Bax and cleaved-caspase-3, as well as increased protein expression of Bcl-2.	3-methylquercetin	10-22	BCL2, apoptosis regulator	Rattus norvegicus	256-261
32307912-4	2020	In addition, I/R-induced oxidative stress was manifestly mitigated by isorhamnetin treatment, as showed by the decreased malondialdehyde (MDA) level and increased antioxidant enzymes activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px).	3-methylquercetin	70-82	catalase	Rattus norvegicus	225-233
32307912-4	2020	In addition, I/R-induced oxidative stress was manifestly mitigated by isorhamnetin treatment, as showed by the decreased malondialdehyde (MDA) level and increased antioxidant enzymes activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px).	3-methylquercetin	70-82	catalase	Rattus norvegicus	235-238
31588915-4	2019	Isorhamnetin-induced G2/M arrest was associated with decreased expression of proliferating cell nuclear antigen as well as cyclin A and cyclin B1.	3-methylquercetin	0-12	proliferating cell nuclear antigen	Homo sapiens	77-111
31588915-4	2019	Isorhamnetin-induced G2/M arrest was associated with decreased expression of proliferating cell nuclear antigen as well as cyclin A and cyclin B1.	3-methylquercetin	0-12	cyclin A2	Homo sapiens	123-131
31588915-4	2019	Isorhamnetin-induced G2/M arrest was associated with decreased expression of proliferating cell nuclear antigen as well as cyclin A and cyclin B1.	3-methylquercetin	0-12	cyclin B1	Homo sapiens	136-145
31588915-5	2019	However, isorhamnetin increased expression of p21WAF1/CIP1, a cyclin-dependent kinase (Cdk) inhibitor, and increased p21 complexed with Cdk2 and Cdc2.	3-methylquercetin	9-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	46-58
31588915-5	2019	However, isorhamnetin increased expression of p21WAF1/CIP1, a cyclin-dependent kinase (Cdk) inhibitor, and increased p21 complexed with Cdk2 and Cdc2.	3-methylquercetin	9-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	46-49
31588915-5	2019	However, isorhamnetin increased expression of p21WAF1/CIP1, a cyclin-dependent kinase (Cdk) inhibitor, and increased p21 complexed with Cdk2 and Cdc2.	3-methylquercetin	9-21	cyclin dependent kinase 2	Homo sapiens	136-140
31588915-5	2019	However, isorhamnetin increased expression of p21WAF1/CIP1, a cyclin-dependent kinase (Cdk) inhibitor, and increased p21 complexed with Cdk2 and Cdc2.	3-methylquercetin	9-21	cyclin dependent kinase 1	Homo sapiens	145-149
31588915-6	2019	In addition, Isorhamnetin-induced apoptosis was associated with increased expression of Fas/Fas ligand, reduced ratio of Bcl-2/Bax expression, truncation of Bid, cytosolic release of cytochrome c, and activation of caspase-8, -9 and -3.	3-methylquercetin	13-25	Fas ligand	Homo sapiens	92-102
31588915-6	2019	In addition, Isorhamnetin-induced apoptosis was associated with increased expression of Fas/Fas ligand, reduced ratio of Bcl-2/Bax expression, truncation of Bid, cytosolic release of cytochrome c, and activation of caspase-8, -9 and -3.	3-methylquercetin	13-25	BCL2 apoptosis regulator	Homo sapiens	121-126
31588915-6	2019	In addition, Isorhamnetin-induced apoptosis was associated with increased expression of Fas/Fas ligand, reduced ratio of Bcl-2/Bax expression, truncation of Bid, cytosolic release of cytochrome c, and activation of caspase-8, -9 and -3.	3-methylquercetin	13-25	BCL2 associated X, apoptosis regulator	Homo sapiens	127-130
31588915-6	2019	In addition, Isorhamnetin-induced apoptosis was associated with increased expression of Fas/Fas ligand, reduced ratio of Bcl-2/Bax expression, truncation of Bid, cytosolic release of cytochrome c, and activation of caspase-8, -9 and -3.	3-methylquercetin	13-25	BH3 interacting domain death agonist	Homo sapiens	157-160
31588915-6	2019	In addition, Isorhamnetin-induced apoptosis was associated with increased expression of Fas/Fas ligand, reduced ratio of Bcl-2/Bax expression, truncation of Bid, cytosolic release of cytochrome c, and activation of caspase-8, -9 and -3.	3-methylquercetin	13-25	cytochrome c, somatic	Homo sapiens	183-195
31588915-6	2019	In addition, Isorhamnetin-induced apoptosis was associated with increased expression of Fas/Fas ligand, reduced ratio of Bcl-2/Bax expression, truncation of Bid, cytosolic release of cytochrome c, and activation of caspase-8, -9 and -3.	3-methylquercetin	13-25	caspase 8	Homo sapiens	215-235
31467176-0	2019	Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small-cell lung cancer cells.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	65-68
31467176-0	2019	Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small-cell lung cancer cells.	3-methylquercetin	0-12	mitogen-activated protein kinase 1	Homo sapiens	69-72
31467176-3	2019	Furthermore, the cell adhesion and Transwell assay showed that treatment with Isorhamnetin (2.5, 5, and 10 muM) for 48 h resulted in a significant inhibition effect on cell adhesion, invasion and migration of A549 cells, depending on concentration, which was associated with the suppression of matrix metalloproteinase (MMP)-2 and MMP-9 activity and protein expression.	3-methylquercetin	78-90	matrix metallopeptidase 2	Homo sapiens	294-326
31467176-3	2019	Furthermore, the cell adhesion and Transwell assay showed that treatment with Isorhamnetin (2.5, 5, and 10 muM) for 48 h resulted in a significant inhibition effect on cell adhesion, invasion and migration of A549 cells, depending on concentration, which was associated with the suppression of matrix metalloproteinase (MMP)-2 and MMP-9 activity and protein expression.	3-methylquercetin	78-90	matrix metallopeptidase 9	Homo sapiens	331-336
31467176-4	2019	Moreover, Isorhamnetin effectively suppressed the expressions of epithelial-to-mesenchymal transition (EMT) markers, as evidenced by the down-regulation of N-cadherin, vimentin and snail, as well as up-regulation of E-cadherin protein expression.	3-methylquercetin	10-22	cadherin 2	Homo sapiens	156-166
31467176-4	2019	Moreover, Isorhamnetin effectively suppressed the expressions of epithelial-to-mesenchymal transition (EMT) markers, as evidenced by the down-regulation of N-cadherin, vimentin and snail, as well as up-regulation of E-cadherin protein expression.	3-methylquercetin	10-22	vimentin	Homo sapiens	168-176
31467176-4	2019	Moreover, Isorhamnetin effectively suppressed the expressions of epithelial-to-mesenchymal transition (EMT) markers, as evidenced by the down-regulation of N-cadherin, vimentin and snail, as well as up-regulation of E-cadherin protein expression.	3-methylquercetin	10-22	snail family transcriptional repressor 1	Homo sapiens	181-186
31467176-4	2019	Moreover, Isorhamnetin effectively suppressed the expressions of epithelial-to-mesenchymal transition (EMT) markers, as evidenced by the down-regulation of N-cadherin, vimentin and snail, as well as up-regulation of E-cadherin protein expression.	3-methylquercetin	10-22	cadherin 1	Homo sapiens	216-226
31467176-6	2019	Taken together, the results of the current study demonstrated that Isorhamnetin may become a good anti-metastastic agent against lung cancer A549 cell line by the suppression of EMT via interrupting Akt/ERK1/2 signaling pathway.	3-methylquercetin	67-79	AKT serine/threonine kinase 1	Homo sapiens	199-202
31467176-6	2019	Taken together, the results of the current study demonstrated that Isorhamnetin may become a good anti-metastastic agent against lung cancer A549 cell line by the suppression of EMT via interrupting Akt/ERK1/2 signaling pathway.	3-methylquercetin	67-79	mitogen-activated protein kinase 3	Homo sapiens	203-209
31443416-4	2019	The BRF is mainly composed of isoorientin, isovitexin, pinosylvin, tricin and isorhamnetin by liquid chromatography-mass spectrometry (LC-MS) analysis.	3-methylquercetin	78-90	BRF1 RNA polymerase III transcription initiation factor subunit	Homo sapiens	4-7
31467486-0	2019	Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-beta1/Smad3 and TGF-beta1/p38 MAPK Pathways.	3-methylquercetin	0-12	transforming growth factor, beta 1	Mus musculus	113-122
31467486-0	2019	Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-beta1/Smad3 and TGF-beta1/p38 MAPK Pathways.	3-methylquercetin	0-12	SMAD family member 3	Mus musculus	123-128
31467486-0	2019	Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-beta1/Smad3 and TGF-beta1/p38 MAPK Pathways.	3-methylquercetin	0-12	transforming growth factor, beta 1	Mus musculus	133-142
31467486-0	2019	Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-beta1/Smad3 and TGF-beta1/p38 MAPK Pathways.	3-methylquercetin	0-12	mitogen-activated protein kinase 14	Mus musculus	143-146
31303834-0	2019	Isorhamnetin in Tsoong blocks Hsp70 expression to promote apoptosis of colon cancer cells.	3-methylquercetin	0-12	heat shock protein family A (Hsp70) member 4	Homo sapiens	30-35
31303834-9	2019	These results show that Isorhamnetin is very critical in Tsoong because Tsoong can down-regulate Hsp70 genes and promote apoptosis of colon cancer cells by inhibiting Hsp70 largely due to the efficacy of Isorhamnetin.	3-methylquercetin	24-36	heat shock protein family A (Hsp70) member 4	Homo sapiens	97-102
31303834-9	2019	These results show that Isorhamnetin is very critical in Tsoong because Tsoong can down-regulate Hsp70 genes and promote apoptosis of colon cancer cells by inhibiting Hsp70 largely due to the efficacy of Isorhamnetin.	3-methylquercetin	24-36	heat shock protein family A (Hsp70) member 4	Homo sapiens	167-172
30772273-0	2019	Isorhamnetin enhanced cortico-hippocampal learning and memory capability in mice with scopolamine-induced amnesia: Role of antioxidant defense, cholinergic and BDNF signaling.	3-methylquercetin	0-12	brain derived neurotrophic factor	Mus musculus	160-164
30983153-8	2019	We proved that Iso inhibited RANKL-induced activation of mitogen-activated protein kinase activation of mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and AKT signalling pathways in BMMs.	3-methylquercetin	15-18	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	29-34
30983153-8	2019	We proved that Iso inhibited RANKL-induced activation of mitogen-activated protein kinase activation of mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and AKT signalling pathways in BMMs.	3-methylquercetin	15-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-167
30983153-8	2019	We proved that Iso inhibited RANKL-induced activation of mitogen-activated protein kinase activation of mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and AKT signalling pathways in BMMs.	3-methylquercetin	15-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	169-178
30983153-8	2019	We proved that Iso inhibited RANKL-induced activation of mitogen-activated protein kinase activation of mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappaB) and AKT signalling pathways in BMMs.	3-methylquercetin	15-18	thymoma viral proto-oncogene 1	Mus musculus	184-187
31138329-0	2019	ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.	3-methylquercetin	174-186	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	59-65
31138329-0	2019	ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.	3-methylquercetin	174-186	collapsin response mediator protein 1	Mus musculus	81-85
30603920-9	2019	Isorhamnetin also decreased hepatic xanthine oxidase (XO) activity without changes in XO protein expression, indicating that anti-hyperuricemic effect of isorhamnetin could be, at least partly, attributable to suppression of UA production by directly inhibiting XO activity in the liver.	3-methylquercetin	0-12	xanthine dehydrogenase	Mus musculus	36-52
30804434-4	2019	We found that 0.1 nM and 1 nM quercetin or 1 nM isorhamnetin significantly increased glucose uptake via translocation of glucose transporter type 4 (GLUT4) to the plasma membrane of L6 myotubes.	3-methylquercetin	48-60	solute carrier family 2 member 4	Homo sapiens	121-147
30804434-4	2019	We found that 0.1 nM and 1 nM quercetin or 1 nM isorhamnetin significantly increased glucose uptake via translocation of glucose transporter type 4 (GLUT4) to the plasma membrane of L6 myotubes.	3-methylquercetin	48-60	solute carrier family 2 member 4	Homo sapiens	149-154
30804434-7	2019	Treatment with siAMPKalpha and siJAK2 abolished quercetin- and isorhamnetin-induced GLUT4 translocation, respectively.	3-methylquercetin	63-75	solute carrier family 2 member 4	Homo sapiens	84-89
30804434-8	2019	However, treatment with siJAK3 did not affect isorhamnetin-induced GLUT4 translocation, indicating that isorhamnetin induced GLUT4 translocation mainly through JAK2, but not JAK3, signalling.	3-methylquercetin	104-116	solute carrier family 2 member 4	Homo sapiens	125-130
30804434-8	2019	However, treatment with siJAK3 did not affect isorhamnetin-induced GLUT4 translocation, indicating that isorhamnetin induced GLUT4 translocation mainly through JAK2, but not JAK3, signalling.	3-methylquercetin	104-116	Janus kinase 2	Homo sapiens	160-164
30804434-12	2019	In conclusion, at low-concentration ranges, quercetin and isorhamnetin promote glucose uptake by increasing GLUT4 translocation via different signalling pathways in skeletal muscle cells; thus, these compounds may possess beneficial functions for maintaining glucose homeostasis by preventing hyperglycaemia at physiological concentrations.	3-methylquercetin	58-70	solute carrier family 2 member 4	Homo sapiens	108-113
30603920-9	2019	Isorhamnetin also decreased hepatic xanthine oxidase (XO) activity without changes in XO protein expression, indicating that anti-hyperuricemic effect of isorhamnetin could be, at least partly, attributable to suppression of UA production by directly inhibiting XO activity in the liver.	3-methylquercetin	0-12	xanthine dehydrogenase	Mus musculus	54-56
29730426-7	2018	However, SIRT1 inhibition (Sirtinol) not only inhibited isorhamnetin-induced Nrf2/HO-1 upregulation and NOX-2/4 downregulation, but also alleviated its anti-apoptotic effects.	3-methylquercetin	56-68	sirtuin 1	Homo sapiens	9-14
30483725-0	2019	Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-kappaB, blocking the TLR4 pathway and reducing ROS generation.	3-methylquercetin	0-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	107-116
30483725-0	2019	Isorhamnetin alleviates lipopolysaccharide-induced inflammatory responses in BV2 microglia by inactivating NF-kappaB, blocking the TLR4 pathway and reducing ROS generation.	3-methylquercetin	0-12	toll-like receptor 4	Mus musculus	131-135
30483725-6	2019	Consistent with these results, isorhamnetin inhibited LPS-stimulated expression of regulatory enzymes, including inducible NO synthase and cyclooxygenase-2 in BV2 cells.	3-methylquercetin	31-43	prostaglandin-endoperoxide synthase 2	Mus musculus	139-155
30483725-7	2019	Isorhamnetin also downregulated LPS-induced production and expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta.	3-methylquercetin	0-12	tumor necrosis factor	Mus musculus	109-136
30483725-7	2019	Isorhamnetin also downregulated LPS-induced production and expression of pro-inflammatory cytokines, such as tumor necrosis factor-alpha and interleukin-1beta.	3-methylquercetin	0-12	interleukin 1 beta	Mus musculus	141-158
30483725-8	2019	The mechanism underlying the anti-inflammatory effects of isorhamnetin was subsequently evaluated; this flavonoid inhibited the nuclear factor (NF)-kappaB signaling pathway by disrupting degradation and phosphorylation of inhibitor kappaB-alpha in the cytoplasm and blocking translocation of NF-kappaB p65 into the nucleus.	3-methylquercetin	58-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	292-301
30483725-8	2019	The mechanism underlying the anti-inflammatory effects of isorhamnetin was subsequently evaluated; this flavonoid inhibited the nuclear factor (NF)-kappaB signaling pathway by disrupting degradation and phosphorylation of inhibitor kappaB-alpha in the cytoplasm and blocking translocation of NF-kappaB p65 into the nucleus.	3-methylquercetin	58-70	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	302-305
30483725-9	2019	In addition, isorhamnetin effectively suppressed LPS-induced expression of Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88.	3-methylquercetin	13-25	toll-like receptor 4	Mus musculus	75-95
30483725-9	2019	In addition, isorhamnetin effectively suppressed LPS-induced expression of Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88.	3-methylquercetin	13-25	toll-like receptor 4	Mus musculus	97-101
30483725-12	2019	Collectively, these results suggested that isorhamnetin may suppress LPS-mediated inflammatory action in BV2 microglia through inactivating the NF-kappaB signaling pathway, antagonizing TLR4 and eliminating ROS accumulation.	3-methylquercetin	43-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	144-153
30483725-12	2019	Collectively, these results suggested that isorhamnetin may suppress LPS-mediated inflammatory action in BV2 microglia through inactivating the NF-kappaB signaling pathway, antagonizing TLR4 and eliminating ROS accumulation.	3-methylquercetin	43-55	toll-like receptor 4	Mus musculus	186-190
30372904-5	2018	Instead, isorhamnetin caused cell cycle S-phase arrest through downregulation of cyclin A.	3-methylquercetin	9-21	cyclin A2	Homo sapiens	81-89
30372904-6	2018	In addition, isorhamnetin decreased the phosphorylation levels of MEK and ERK in the Ras/MAPK pathway, which is involved in regulating cell proliferation, differentiation and apoptosis.	3-methylquercetin	13-25	mitogen-activated protein kinase kinase 7	Homo sapiens	66-69
30372904-6	2018	In addition, isorhamnetin decreased the phosphorylation levels of MEK and ERK in the Ras/MAPK pathway, which is involved in regulating cell proliferation, differentiation and apoptosis.	3-methylquercetin	13-25	mitogen-activated protein kinase 1	Homo sapiens	74-77
30372904-6	2018	In addition, isorhamnetin decreased the phosphorylation levels of MEK and ERK in the Ras/MAPK pathway, which is involved in regulating cell proliferation, differentiation and apoptosis.	3-methylquercetin	13-25	mitogen-activated protein kinase 1	Homo sapiens	89-93
29730426-4	2018	Here, we found that isorhamnetin dose-dependently protected H9c2 cardiomyocytes against H/R-induced injure, as evidenced by the reduction in lactate dehydrogenase (LDH) levels, increases in cell viability, superoxide dismutase (SOD) and catalase (CAT) activity, with the maximal effects at 25 muMu.	3-methylquercetin	20-32	catalase	Homo sapiens	237-245
29730426-4	2018	Here, we found that isorhamnetin dose-dependently protected H9c2 cardiomyocytes against H/R-induced injure, as evidenced by the reduction in lactate dehydrogenase (LDH) levels, increases in cell viability, superoxide dismutase (SOD) and catalase (CAT) activity, with the maximal effects at 25 muMu.	3-methylquercetin	20-32	catalase	Homo sapiens	247-250
30772801-5	2019	Isorhamnetins @ 11.4mug/mL and 5.7mug/mL has significantly decreased EC necrotic rate, while the increased vWf concentration due to oxidant (200 mol/L of H2O2) was significantly decreased by 5.7mug/mL versus 11.4 and 22.8mug/mL isorhamnetin.	3-methylquercetin	0-13	von Willebrand factor	Homo sapiens	107-110
30772801-5	2019	Isorhamnetins @ 11.4mug/mL and 5.7mug/mL has significantly decreased EC necrotic rate, while the increased vWf concentration due to oxidant (200 mol/L of H2O2) was significantly decreased by 5.7mug/mL versus 11.4 and 22.8mug/mL isorhamnetin.	3-methylquercetin	228-240	von Willebrand factor	Homo sapiens	107-110
30772801-6	2019	Also, the increased in TM and LDH in injured cells was reversed to normal level with 5.7 to 11.4mug/mL isorhamnetin.	3-methylquercetin	103-115	thrombomodulin	Homo sapiens	23-25
29730426-7	2018	However, SIRT1 inhibition (Sirtinol) not only inhibited isorhamnetin-induced Nrf2/HO-1 upregulation and NOX-2/4 downregulation, but also alleviated its anti-apoptotic effects.	3-methylquercetin	56-68	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
29730426-7	2018	However, SIRT1 inhibition (Sirtinol) not only inhibited isorhamnetin-induced Nrf2/HO-1 upregulation and NOX-2/4 downregulation, but also alleviated its anti-apoptotic effects.	3-methylquercetin	56-68	heme oxygenase 1	Homo sapiens	82-86
29730426-7	2018	However, SIRT1 inhibition (Sirtinol) not only inhibited isorhamnetin-induced Nrf2/HO-1 upregulation and NOX-2/4 downregulation, but also alleviated its anti-apoptotic effects.	3-methylquercetin	56-68	cytochrome b-245 beta chain	Homo sapiens	104-109
29730426-8	2018	Taken together, these data indicate that isorhamnetin can exhibit positive effect on H/R-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes, which is partly attributable to the upregulation of SIRT1 and Nrf2/HO-1-mediated antioxidant signaling pathway.	3-methylquercetin	41-53	sirtuin 1	Homo sapiens	226-231
29730426-8	2018	Taken together, these data indicate that isorhamnetin can exhibit positive effect on H/R-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes, which is partly attributable to the upregulation of SIRT1 and Nrf2/HO-1-mediated antioxidant signaling pathway.	3-methylquercetin	41-53	NFE2 like bZIP transcription factor 2	Homo sapiens	236-240
29730426-5	2018	In addition, isorhamnetin treatment significantly inhibited apoptosis in H/R-induced H9c2 cardiomyocytes and ameliorated H/R-induced myocardial injure in vivo, concomitant with the upregulation of sirtuin 1 (SIRT1) expression.	3-methylquercetin	13-25	sirtuin 1	Homo sapiens	197-206
29730426-8	2018	Taken together, these data indicate that isorhamnetin can exhibit positive effect on H/R-induced injure by attenuating apoptosis and oxidative stress in H9c2 cardiomyocytes, which is partly attributable to the upregulation of SIRT1 and Nrf2/HO-1-mediated antioxidant signaling pathway.	3-methylquercetin	41-53	heme oxygenase 1	Homo sapiens	241-245
29684859-0	2018	Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.	3-methylquercetin	0-12	mitogen-activated protein kinase 14	Mus musculus	80-83
29730426-5	2018	In addition, isorhamnetin treatment significantly inhibited apoptosis in H/R-induced H9c2 cardiomyocytes and ameliorated H/R-induced myocardial injure in vivo, concomitant with the upregulation of sirtuin 1 (SIRT1) expression.	3-methylquercetin	13-25	sirtuin 1	Homo sapiens	208-213
29730426-6	2018	Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes.	3-methylquercetin	36-48	NFE2 like bZIP transcription factor 2	Homo sapiens	113-156
29730426-6	2018	Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes.	3-methylquercetin	36-48	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
29730426-6	2018	Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes.	3-methylquercetin	36-48	heme oxygenase 1	Homo sapiens	168-184
29730426-6	2018	Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes.	3-methylquercetin	36-48	heme oxygenase 1	Homo sapiens	186-190
29730426-6	2018	Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes.	3-methylquercetin	36-48	cytochrome b-245 beta chain	Homo sapiens	224-241
29730426-6	2018	Mechanism studies demonstrated that isorhamnetin pretreatment remarkably abolished H/R-induced downregulation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expressions and upregulation of NADPH oxidase-2/4 (NOX-2/4) expressions in cardiomyocytes.	3-methylquercetin	36-48	cytochrome b-245 beta chain	Homo sapiens	243-250
29684859-0	2018	Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.	3-methylquercetin	0-12	peroxisome proliferator activated receptor alpha	Mus musculus	84-94
29684859-8	2018	The present study investigated that isorhamnetin inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.	3-methylquercetin	36-48	mitogen-activated protein kinase 14	Mus musculus	86-89
29684859-8	2018	The present study investigated that isorhamnetin inhibits apoptosis and autophagy via P38/PPAR-alpha pathway in mice.	3-methylquercetin	36-48	peroxisome proliferator activated receptor alpha	Mus musculus	90-100
29704670-0	2018	Anti-inflammatory effects of isorhamnetin on LPS-stimulated human gingival fibroblasts by activating Nrf2 signaling pathway.	3-methylquercetin	29-41	NFE2 like bZIP transcription factor 2	Homo sapiens	101-105
29704670-5	2018	The results demonstrated that isorhamnetin attenuated LPS-induced release of PGE2, NO, IL-6, and IL-8 in HGFs.	3-methylquercetin	30-42	interleukin 6	Homo sapiens	87-91
29704670-5	2018	The results demonstrated that isorhamnetin attenuated LPS-induced release of PGE2, NO, IL-6, and IL-8 in HGFs.	3-methylquercetin	30-42	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
29704670-7	2018	The expression of Nrf2 and HO-1 were up-regulated by treatment of isorhamnetin.	3-methylquercetin	66-78	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
29704670-7	2018	The expression of Nrf2 and HO-1 were up-regulated by treatment of isorhamnetin.	3-methylquercetin	66-78	heme oxygenase 1	Homo sapiens	27-31
29704670-8	2018	Furthermore, knockdown of Nrf2 by siRNA reversed the anti-inflammatory effects of isorhamnetin.	3-methylquercetin	82-94	NFE2 like bZIP transcription factor 2	Homo sapiens	26-30
29704670-9	2018	In conclusion, these results suggested that isorhamnetin inhibited LPS-induced inflammation in HGFs by activating Nrf2 signaling pathway.	3-methylquercetin	44-56	NFE2 like bZIP transcription factor 2	Homo sapiens	114-118
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	3-methylquercetin	106-118	estrogen receptor 1 (alpha)	Mus musculus	15-19
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	3-methylquercetin	106-118	prostaglandin-endoperoxide synthase 2	Mus musculus	21-26
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	3-methylquercetin	106-118	peroxisome proliferator activated receptor alpha	Mus musculus	28-33
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	3-methylquercetin	106-118	peroxisome proliferator activated receptor gamma	Mus musculus	35-40
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	3-methylquercetin	106-118	prostaglandin-endoperoxide synthase 1	Mus musculus	42-47
29902886-14	2018	In particular, ESR1, PTGS2, PPARA, PPARG, PTGS1 and CA2 were regulated by the flavonoids (kaempferide and isorhamnetin).	3-methylquercetin	106-118	carbonic anhydrase 2	Mus musculus	52-55
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	3-methylquercetin	133-145	ribonuclease P/MRP subunit p14	Homo sapiens	33-36
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	cyclin B1	Homo sapiens	74-83
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	cell division cycle 25C	Homo sapiens	110-116
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	cyclin dependent kinase 1	Homo sapiens	110-114
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	checkpoint kinase 2	Homo sapiens	141-160
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	checkpoint kinase 2	Homo sapiens	162-166
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	cell division cycle 25C	Homo sapiens	169-175
29563987-8	2018	It was demonstrated that isorhamnetin inhibited the protein expression of cyclin B1, cell division cycle 25C (Cdc25C) and Cdc2, but enhanced checkpoint kinase 2 (Chk2), Cdc25C and Cdc2 phosphorylation.	3-methylquercetin	25-37	cyclin dependent kinase 1	Homo sapiens	122-126
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	3-methylquercetin	133-145	interleukin 23 subunit alpha	Homo sapiens	38-41
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	3-methylquercetin	133-145	H3 histone pseudogene 16	Homo sapiens	43-46
29332828-9	2018	Using the UPLC-MS/MS data, peaks P14, P19, P21, and P30 were respectively identified as chlorogenic acid, quercetin, kaempferol, and isorhamnetin, and then the results were confirmed through comparison with the standards and other references.	3-methylquercetin	133-145	centromere protein V	Homo sapiens	52-55
29115489-7	2018	Taken together, the present results demonstrated that isorhamnetin protected human RPE cells from oxidative stress-induced cell death, and this effect was associated with activation of the PI3K/Akt signaling pathway.	3-methylquercetin	54-66	AKT serine/threonine kinase 1	Homo sapiens	194-197
29145845-9	2017	Based on the SDTNBI method and experimental verification, Isorhamnetin and Kaempferide effectively increased melanogenesis by targeting the MC1R-MITF signaling pathway, MAPK signaling pathway, PPAR signaling pathway (PPARA, PPARD, PPARG), arachidonic acid metabolism pathway (ALOX12, ALOX15, CBR1) and serotonergic synapses (ALOX12, ALOX15) in the treatment of vitiligo from a network perspective.	3-methylquercetin	58-70	melanocortin 1 receptor	Mus musculus	140-144
29145845-7	2017	Isorhamnetin and Kaempferide significantly increased the expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT) and the tyrosinase activity in B16F10 cells.	3-methylquercetin	0-12	melanocortin 1 receptor	Mus musculus	99-103
29145845-7	2017	Isorhamnetin and Kaempferide significantly increased the expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT) and the tyrosinase activity in B16F10 cells.	3-methylquercetin	0-12	melanogenesis associated transcription factor	Mus musculus	105-109
29145845-7	2017	Isorhamnetin and Kaempferide significantly increased the expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT) and the tyrosinase activity in B16F10 cells.	3-methylquercetin	0-12	tyrosinase-related protein 1	Mus musculus	116-121
29145845-7	2017	Isorhamnetin and Kaempferide significantly increased the expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT) and the tyrosinase activity in B16F10 cells.	3-methylquercetin	0-12	dopachrome tautomerase	Mus musculus	126-129
29145845-7	2017	Isorhamnetin and Kaempferide significantly increased the expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT) and the tyrosinase activity in B16F10 cells.	3-methylquercetin	0-12	tyrosinase	Mus musculus	139-149
29145845-8	2017	Isorhamnetin and Kaempferide significantly increased the mRNA-expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT), the protein level of MITF and the tyrosinase activity.	3-methylquercetin	0-12	melanocortin 1 receptor	Mus musculus	104-108
29145845-8	2017	Isorhamnetin and Kaempferide significantly increased the mRNA-expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT), the protein level of MITF and the tyrosinase activity.	3-methylquercetin	0-12	melanogenesis associated transcription factor	Mus musculus	110-114
29145845-8	2017	Isorhamnetin and Kaempferide significantly increased the mRNA-expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT), the protein level of MITF and the tyrosinase activity.	3-methylquercetin	0-12	tyrosinase-related protein 1	Mus musculus	121-126
29145845-8	2017	Isorhamnetin and Kaempferide significantly increased the mRNA-expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT), the protein level of MITF and the tyrosinase activity.	3-methylquercetin	0-12	dopachrome tautomerase	Mus musculus	131-134
29145845-8	2017	Isorhamnetin and Kaempferide significantly increased the mRNA-expression of melanin-biosynthetic genes (MC1R, MITF, TYR, TYRP1 and DCT), the protein level of MITF and the tyrosinase activity.	3-methylquercetin	0-12	tyrosinase	Mus musculus	171-181
29115489-5	2018	In addition, isorhamnetin pretreatment inhibited hydrogen peroxide (H2O2)-induced reactive oxygen species (ROS) production and caspase-3 activation in RPE cells.	3-methylquercetin	13-25	caspase 3	Homo sapiens	127-136
29115489-6	2018	Furthermore, isorhamnetin pretreatment significantly increased the phosphorylation of phosphoinositide 3-kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in RPE cells exposed to H2O2, compared with cells treated with H2O2 alone.	3-methylquercetin	13-25	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	86-111
29115489-6	2018	Furthermore, isorhamnetin pretreatment significantly increased the phosphorylation of phosphoinositide 3-kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in RPE cells exposed to H2O2, compared with cells treated with H2O2 alone.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Homo sapiens	123-152
29115489-6	2018	Furthermore, isorhamnetin pretreatment significantly increased the phosphorylation of phosphoinositide 3-kinase (PI3K) and AKT serine/threonine kinase 1 (Akt) in RPE cells exposed to H2O2, compared with cells treated with H2O2 alone.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Homo sapiens	154-157
28936788-0	2017	Isorhamnetin derivatives and piscidic acid for hypercholesterolemia: cholesterol permeability, HMG-CoA reductase inhibition, and docking studies.	3-methylquercetin	0-12	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	95-112
28731170-0	2017	Isorhamnetin inhibits IL-1beta-induced expression of inflammatory mediators in human chondrocytes.	3-methylquercetin	0-12	interleukin 1 beta	Homo sapiens	22-30
28322972-4	2017	Many natural flavonoids and synthetic stilbenes show inhibitory activity toward CYP1B1 expression and function, notably isorhamnetin and 2,4,3",5"-tetramethoxystilbene.	3-methylquercetin	120-132	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	80-86
29145845-9	2017	Based on the SDTNBI method and experimental verification, Isorhamnetin and Kaempferide effectively increased melanogenesis by targeting the MC1R-MITF signaling pathway, MAPK signaling pathway, PPAR signaling pathway (PPARA, PPARD, PPARG), arachidonic acid metabolism pathway (ALOX12, ALOX15, CBR1) and serotonergic synapses (ALOX12, ALOX15) in the treatment of vitiligo from a network perspective.	3-methylquercetin	58-70	melanogenesis associated transcription factor	Mus musculus	145-149
28232125-2	2017	Activities of CYP2E1 and CYP3A were measured in the presence of quercetin, myricetin, or isorhamnetin in hepatic microsomal pools from male and female donors.	3-methylquercetin	89-101	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	14-20
28715866-0	2017	Protective effects of isorhamnetin on N2a cell against endoplasmic reticulum stress-induced injury is mediated by PKCepsilon.	3-methylquercetin	22-34	protein kinase C, epsilon	Mus musculus	114-124
28715866-4	2017	This study was to investigate whether Iso can inhibit ERS-induced apoptosis in N2a cells, and the protective effects are involved in PKCepsilon-mediated Ca2+ homeostasis and inhibition of ROS.	3-methylquercetin	38-41	protein kinase C, epsilon	Mus musculus	133-143
28715866-8	2017	In addition, Iso can promote PKCepsilon phosphorylation, and epsilonV1-2 (a PKCepsilon inhibitor) drastically attenuated the protective effects of Iso against ERS injury in N2a cells.	3-methylquercetin	13-16	protein kinase C, epsilon	Mus musculus	29-39
28715866-8	2017	In addition, Iso can promote PKCepsilon phosphorylation, and epsilonV1-2 (a PKCepsilon inhibitor) drastically attenuated the protective effects of Iso against ERS injury in N2a cells.	3-methylquercetin	147-150	protein kinase C, epsilon	Mus musculus	76-86
28715866-9	2017	In conclusion, we firstly demonstrated that Iso can elicit protective effects against ERS injury in N2a cells and these effects are mediated at least in part via PKCepsilon pathway.	3-methylquercetin	44-47	protein kinase C, epsilon	Mus musculus	162-172
28176246-8	2017	In vitro studies performed in neonatal rat cardiomyocytes confirmed that isorhamnetin could attenuate cardiomyocyte hypertrophy induced by angiotensin II, which was associated with phosphatidylinositol 3-kinase-AKT signaling pathway.	3-methylquercetin	73-85	angiotensinogen	Rattus norvegicus	139-153
28232125-2	2017	Activities of CYP2E1 and CYP3A were measured in the presence of quercetin, myricetin, or isorhamnetin in hepatic microsomal pools from male and female donors.	3-methylquercetin	89-101	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	25-30
26859194-0	2016	Protective Effects of Isorhamnetin on Cardiomyocytes Against Anoxia/Reoxygenation-induced Injury Is Mediated by SIRT1.	3-methylquercetin	22-34	sirtuin 1	Homo sapiens	112-117
28235721-7	2017	Galangin, kaempferol, and isorhamnetin (100muM) showed weaker activity on the hERG currents.	3-methylquercetin	26-38	ETS transcription factor ERG	Homo sapiens	78-82
27161367-7	2016	Treatment of experimental stroke mice with isorhamnetin activated Nrf2/HO-1, suppressed iNOS/NO, and led to reduced formation of MDA and 3-NT in ipsilateral cortex.	3-methylquercetin	43-55	nuclear factor, erythroid derived 2, like 2	Mus musculus	66-70
27161367-7	2016	Treatment of experimental stroke mice with isorhamnetin activated Nrf2/HO-1, suppressed iNOS/NO, and led to reduced formation of MDA and 3-NT in ipsilateral cortex.	3-methylquercetin	43-55	heme oxygenase 1	Mus musculus	71-75
27161367-7	2016	Treatment of experimental stroke mice with isorhamnetin activated Nrf2/HO-1, suppressed iNOS/NO, and led to reduced formation of MDA and 3-NT in ipsilateral cortex.	3-methylquercetin	43-55	nitric oxide synthase 2, inducible	Mus musculus	88-92
27161367-8	2016	In addition, treatment of experimental stroke mice with isorhamnetin suppressed activity of MPO (a biomarker of neutrophil infiltration) and reduced protein levels of IL-1beta, IL-6, and TNF-alpha in ipsilateral cortex.	3-methylquercetin	56-68	interleukin 1 beta	Mus musculus	167-175
27161367-8	2016	In addition, treatment of experimental stroke mice with isorhamnetin suppressed activity of MPO (a biomarker of neutrophil infiltration) and reduced protein levels of IL-1beta, IL-6, and TNF-alpha in ipsilateral cortex.	3-methylquercetin	56-68	interleukin 6	Mus musculus	177-181
27161367-8	2016	In addition, treatment of experimental stroke mice with isorhamnetin suppressed activity of MPO (a biomarker of neutrophil infiltration) and reduced protein levels of IL-1beta, IL-6, and TNF-alpha in ipsilateral cortex.	3-methylquercetin	56-68	tumor necrosis factor	Mus musculus	187-196
27138362-5	2016	Our results showed that isorhamnetin markedly decreased TNF-alpha, IL-1beta, and IL-6 concentrations and suppressed the activation of NF-kappaB signaling.	3-methylquercetin	24-36	tumor necrosis factor	Mus musculus	56-65
27138362-5	2016	Our results showed that isorhamnetin markedly decreased TNF-alpha, IL-1beta, and IL-6 concentrations and suppressed the activation of NF-kappaB signaling.	3-methylquercetin	24-36	interleukin 1 beta	Mus musculus	67-75
27138362-5	2016	Our results showed that isorhamnetin markedly decreased TNF-alpha, IL-1beta, and IL-6 concentrations and suppressed the activation of NF-kappaB signaling.	3-methylquercetin	24-36	interleukin 6	Mus musculus	81-85
27138362-6	2016	Meanwhile, isorhamnetin reduced the amount of inflammatory cells, the lung wet-to-dry weight ratio, protein leakage, and myeloperoxidase activity.	3-methylquercetin	11-23	myeloperoxidase	Mus musculus	121-136
27151496-0	2016	Isorhamnetin attenuates liver fibrosis by inhibiting TGF-beta/Smad signaling and relieving oxidative stress.	3-methylquercetin	0-12	transforming growth factor, beta 1	Mus musculus	53-61
27151496-4	2016	Isorhamnetin inhibited transforming growth factor (TGF)-beta1-induced expression of alpha-smooth muscle actin (alpha-SMA), plasminogen activator inhibitor-1 (PAI-1), and collagen in primary murine HSCs and LX-2 cells.	3-methylquercetin	0-12	actin alpha 2, smooth muscle, aorta	Mus musculus	84-109
27151496-4	2016	Isorhamnetin inhibited transforming growth factor (TGF)-beta1-induced expression of alpha-smooth muscle actin (alpha-SMA), plasminogen activator inhibitor-1 (PAI-1), and collagen in primary murine HSCs and LX-2 cells.	3-methylquercetin	0-12	actin alpha 2, smooth muscle, aorta	Mus musculus	111-120
27151496-4	2016	Isorhamnetin inhibited transforming growth factor (TGF)-beta1-induced expression of alpha-smooth muscle actin (alpha-SMA), plasminogen activator inhibitor-1 (PAI-1), and collagen in primary murine HSCs and LX-2 cells.	3-methylquercetin	0-12	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	123-156
27151496-4	2016	Isorhamnetin inhibited transforming growth factor (TGF)-beta1-induced expression of alpha-smooth muscle actin (alpha-SMA), plasminogen activator inhibitor-1 (PAI-1), and collagen in primary murine HSCs and LX-2 cells.	3-methylquercetin	0-12	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	158-163
27151496-5	2016	The TGF-beta1- or Smad-induced luciferase reporter activity of Smad binding elements was significantly decreased by isorhamnetin with a concomitant decrease in Smad2/3 phosphorylation.	3-methylquercetin	116-128	transforming growth factor, beta 1	Mus musculus	4-13
27151496-6	2016	Isorhamnetin increased the nuclear translocation of Nrf2 in HSCs and increased antioxidant response element reporter gene activity.	3-methylquercetin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	52-56
27151496-10	2016	Isorhamnetin significantly prevented CCl4-induced increases in serum alanine transaminase and aspartate transaminase levels, and caused histopathological changes characterized by decreases in hepatic degeneration, inflammatory cell infiltration, and collagen accumulation.	3-methylquercetin	0-12	chemokine (C-C motif) ligand 4	Mus musculus	37-41
27151496-12	2016	Isorhamnetin attenuated the CCl4-induced increase in the number of 4-hydroxynonenal and nitrotyrosine-positive cells, and prevented glutathione depletion.	3-methylquercetin	0-12	chemokine (C-C motif) ligand 4	Mus musculus	28-32
27151496-13	2016	We propose that isorhamnetin inhibits the TGF-beta/Smad signaling pathway and relieves oxidative stress, thus inhibiting HSC activation and preventing liver fibrosis.	3-methylquercetin	16-28	transforming growth factor, beta 1	Mus musculus	42-50
26859194-6	2016	The results showed that IsoRN can reduce A/R-induced injury by decreasing the level of lactate dehydrogenase and creatine phosphokinase release from the cardiomyocytes, increasing cell viability and expression of SIRT1, reducing the generation of reactive oxygen species, inhibiting opening of mitochondrial permeability transition pores and loss of Deltapsim and activation of caspase-3, and decreasing the release of cytochrome c, and reducing apoptosis.	3-methylquercetin	24-29	sirtuin 1	Homo sapiens	213-218
26859194-6	2016	The results showed that IsoRN can reduce A/R-induced injury by decreasing the level of lactate dehydrogenase and creatine phosphokinase release from the cardiomyocytes, increasing cell viability and expression of SIRT1, reducing the generation of reactive oxygen species, inhibiting opening of mitochondrial permeability transition pores and loss of Deltapsim and activation of caspase-3, and decreasing the release of cytochrome c, and reducing apoptosis.	3-methylquercetin	24-29	caspase 3	Homo sapiens	378-387
26859194-6	2016	The results showed that IsoRN can reduce A/R-induced injury by decreasing the level of lactate dehydrogenase and creatine phosphokinase release from the cardiomyocytes, increasing cell viability and expression of SIRT1, reducing the generation of reactive oxygen species, inhibiting opening of mitochondrial permeability transition pores and loss of Deltapsim and activation of caspase-3, and decreasing the release of cytochrome c, and reducing apoptosis.	3-methylquercetin	24-29	cytochrome c, somatic	Homo sapiens	419-431
26859194-7	2016	In addition, sirtinol, a SIRT1 inhibitor, drastically reduced the protective effects of IsoRN on cardioprotective effects in cardiomocytes.	3-methylquercetin	88-93	sirtuin 1	Homo sapiens	25-30
26984113-9	2016	The release of interferon-gamma induced protein 10 by primary lymphocytes was significantly reduced following treatment with 1 microm isorhamnetin (P&lt;0 05).	3-methylquercetin	134-146	interferon gamma	Homo sapiens	15-31
27150638-6	2016	Proto-oncogene tyrosine-protein kinase (Src) was identified as its membrane target and the dissociation constant (Kd) between Src and isorhamnetin was 3.81 muM.	3-methylquercetin	134-146	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-43
27150638-6	2016	Proto-oncogene tyrosine-protein kinase (Src) was identified as its membrane target and the dissociation constant (Kd) between Src and isorhamnetin was 3.81 muM.	3-methylquercetin	134-146	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	126-129
27150638-7	2016	Furthermore, anti-leukemia effects of isorhamnetin were mediated by Src through inducing G2/M cell cycle arrest.	3-methylquercetin	38-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	68-71
26830132-0	2016	The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation.	3-methylquercetin	29-41	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-110
26974691-5	2016	Isorhamnetin suppressed the release of tumor necrosis factor (TNF)-alpha and interleukin (IL)-12.	3-methylquercetin	0-12	tumor necrosis factor	Homo sapiens	39-72
26974691-7	2016	Isorhamnetin inhibited IFN-gamma-mediated stimulation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase and showed high-affinity binding to these kinases (binding constants: 4.46 x 10(6) M(-1) and 7.6 x 10(6) M(-1), respectively).	3-methylquercetin	0-12	interferon gamma	Homo sapiens	23-32
26974691-7	2016	Isorhamnetin inhibited IFN-gamma-mediated stimulation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase and showed high-affinity binding to these kinases (binding constants: 4.46 x 10(6) M(-1) and 7.6 x 10(6) M(-1), respectively).	3-methylquercetin	0-12	mitogen-activated protein kinase 14	Homo sapiens	99-102
26830132-0	2016	The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation.	3-methylquercetin	29-41	heme oxygenase 1	Mus musculus	121-125
26830132-0	2016	The cytoprotective effect of isorhamnetin against oxidative stress is mediated by the upregulation of the Nrf2-dependent HO-1 expression in C2C12 myoblasts through scavenging reactive oxygen species and ERK inactivation.	3-methylquercetin	29-41	mitogen-activated protein kinase 1	Mus musculus	203-206
26830132-3	2016	Isorhamnetin also significantly attenuated H2O2-induced DNA damage and apoptosis, and increased the levels of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its phosphorylation associated with the induction of heme oxygenase-1 (HO-1).	3-methylquercetin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-157
26830132-3	2016	Isorhamnetin also significantly attenuated H2O2-induced DNA damage and apoptosis, and increased the levels of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its phosphorylation associated with the induction of heme oxygenase-1 (HO-1).	3-methylquercetin	0-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	159-163
26830132-3	2016	Isorhamnetin also significantly attenuated H2O2-induced DNA damage and apoptosis, and increased the levels of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its phosphorylation associated with the induction of heme oxygenase-1 (HO-1).	3-methylquercetin	0-12	heme oxygenase 1	Mus musculus	222-238
26830132-3	2016	Isorhamnetin also significantly attenuated H2O2-induced DNA damage and apoptosis, and increased the levels of the nuclear factor erythroid 2-related factor 2 (Nrf2) and its phosphorylation associated with the induction of heme oxygenase-1 (HO-1).	3-methylquercetin	0-12	heme oxygenase 1	Mus musculus	240-244
26830132-4	2016	However, the protective effects of isorhamnetin on H2O2-induced ROS and growth inhibition were significantly abolished by an HO-1 competitive inhibitor.	3-methylquercetin	35-47	heme oxygenase 1	Mus musculus	125-129
26830132-5	2016	Moreover, the potential of isorhamnetin to mediate HO-1 induction and protect against H2O2-mediated growth inhibition was abrogated by transient transfection with Nrf2-specific small interfering RNA.	3-methylquercetin	27-39	heme oxygenase 1	Mus musculus	51-55
26830132-5	2016	Moreover, the potential of isorhamnetin to mediate HO-1 induction and protect against H2O2-mediated growth inhibition was abrogated by transient transfection with Nrf2-specific small interfering RNA.	3-methylquercetin	27-39	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167
26830132-6	2016	Additionally, isorhamnetin induced the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK.	3-methylquercetin	14-26	mitogen-activated protein kinase 1	Mus musculus	104-141
26830132-6	2016	Additionally, isorhamnetin induced the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK.	3-methylquercetin	14-26	mitogen-activated protein kinase 1	Mus musculus	143-146
26830132-6	2016	Additionally, isorhamnetin induced the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK.	3-methylquercetin	14-26	mitogen-activated protein kinase 8	Mus musculus	149-172
26830132-6	2016	Additionally, isorhamnetin induced the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK.	3-methylquercetin	14-26	mitogen-activated protein kinase 8	Mus musculus	174-177
26830132-6	2016	Additionally, isorhamnetin induced the activation of mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK.	3-methylquercetin	14-26	mitogen-activated protein kinase 14	Mus musculus	184-192
26830132-8	2016	Collectively, these results demonstrate that isorhamnetin augments the cellular antioxidant defense capacity by activating the Nrf2/HO-1 pathway involving the activation of the ERK pathway, thus protecting the C2C12 cells from H2O2-induced cytotoxicity.	3-methylquercetin	45-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	127-131
27803454-0	2016	Isorhamnetin Inhibits Reactive Oxygen Species-Dependent Hypoxia Inducible Factor (HIF)-1alpha Accumulation.	3-methylquercetin	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-93
26830132-8	2016	Collectively, these results demonstrate that isorhamnetin augments the cellular antioxidant defense capacity by activating the Nrf2/HO-1 pathway involving the activation of the ERK pathway, thus protecting the C2C12 cells from H2O2-induced cytotoxicity.	3-methylquercetin	45-57	heme oxygenase 1	Mus musculus	132-136
26830132-8	2016	Collectively, these results demonstrate that isorhamnetin augments the cellular antioxidant defense capacity by activating the Nrf2/HO-1 pathway involving the activation of the ERK pathway, thus protecting the C2C12 cells from H2O2-induced cytotoxicity.	3-methylquercetin	45-57	mitogen-activated protein kinase 1	Mus musculus	177-180
26578299-7	2016	Besides its well-known inhibition on the mitochondria-dependent or intrinsic apoptotic pathway, isorhamnetin also reduced activation of the extrinsic apoptotic pathway, as characterized by the decreased expression and activity of caspase 3 and caspase 8.	3-methylquercetin	96-108	caspase 3	Homo sapiens	230-239
26578299-7	2016	Besides its well-known inhibition on the mitochondria-dependent or intrinsic apoptotic pathway, isorhamnetin also reduced activation of the extrinsic apoptotic pathway, as characterized by the decreased expression and activity of caspase 3 and caspase 8.	3-methylquercetin	96-108	caspase 8	Homo sapiens	244-253
26578299-8	2016	Furthermore, pretreatment with isorhamnetin specifically inhibited FAS/FASL expression and suppressed nuclear factor-kappa B nuclear translocation.	3-methylquercetin	31-43	Fas ligand	Homo sapiens	71-75
26578299-12	2016	Isorhamnetin inhibits FasL-mediated extrinsic apoptosis and neurotrophic factor kappaB (NF-kappaB) nuclear translocation, which can induce the cell DNA damage.	3-methylquercetin	0-12	Fas ligand	Homo sapiens	22-26
26578299-12	2016	Isorhamnetin inhibits FasL-mediated extrinsic apoptosis and neurotrophic factor kappaB (NF-kappaB) nuclear translocation, which can induce the cell DNA damage.	3-methylquercetin	0-12	nuclear factor kappa B subunit 1	Homo sapiens	88-97
26276127-2	2016	The aim of this study was to investigate the protective effect of isorhamnetin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice by inhibiting the expression of cyclooxygenase-2 (COX-2).	3-methylquercetin	66-78	prostaglandin-endoperoxide synthase 2	Mus musculus	179-195
26276127-2	2016	The aim of this study was to investigate the protective effect of isorhamnetin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice by inhibiting the expression of cyclooxygenase-2 (COX-2).	3-methylquercetin	66-78	prostaglandin-endoperoxide synthase 2	Mus musculus	197-202
26276127-9	2016	Furthermore, isorhamnetin pretreatment significantly suppressed LPS-induced activation of COX-2.	3-methylquercetin	13-25	prostaglandin-endoperoxide synthase 2	Mus musculus	90-95
26276127-10	2016	Isorhamnetin has been demonstrated to protect mice from LPS-induced ALI by inhibiting the expression of COX-2.	3-methylquercetin	0-12	prostaglandin-endoperoxide synthase 2	Mus musculus	104-109
26775807-3	2016	Here, we identified that isorhamnetin, a naturally occurring compound in fruits and vegetables and the metabolite of quercetin, is a novel antagonist of PPARgamma.	3-methylquercetin	25-37	peroxisome proliferator activated receptor gamma	Homo sapiens	153-162
26775807-4	2016	Isorhamnetin treatment inhibited the adipocyte differentiation induced by the PPARgamma agonist rosiglitazone, reduced obesity development and ameliorated hepatic steatosis induced by both high-fat diet treatment and leptin deficiency.	3-methylquercetin	0-12	peroxisome proliferator activated receptor gamma	Homo sapiens	78-87
27803454-4	2016	Isorhamnetin significantly repressed cobalt chloride (CoCl2)- or hypoxia-induced hypoxia inducible factor-1alpha (HIF-1alpha) accumulation in HCT116 and HT29 cells.	3-methylquercetin	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	81-112
27803454-4	2016	Isorhamnetin significantly repressed cobalt chloride (CoCl2)- or hypoxia-induced hypoxia inducible factor-1alpha (HIF-1alpha) accumulation in HCT116 and HT29 cells.	3-methylquercetin	0-12	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
27803454-5	2016	When compared with quercetin, isorhamnetin showed potent inhibition of HIF-1alpha.	3-methylquercetin	30-42	hypoxia inducible factor 1 subunit alpha	Homo sapiens	71-81
27803454-9	2016	Consistently, overexpressed HIF-1alpha was decreased by isorhamnetin or N-acetyl-L-cysteine in HEK293 cells.	3-methylquercetin	56-68	hypoxia inducible factor 1 subunit alpha	Homo sapiens	28-38
26502751-0	2015	Isorhamnetin inhibits cell proliferation and induces apoptosis  in breast cancer via Akt and mitogen-activated protein kinase kinase signaling pathways.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	85-88
26502751-3	2015	The present study investigated the potential effects of the natural product, isorhamnetin on breast cancer, and examined the effects of isorhamnetin on the Akt/mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK)/MAPK kinase (MEK) signaling cascades, which are two important signaling pathways for endocrine therapy resistance in breast cancer.	3-methylquercetin	136-148	AKT serine/threonine kinase 1	Homo sapiens	156-159
26502751-3	2015	The present study investigated the potential effects of the natural product, isorhamnetin on breast cancer, and examined the effects of isorhamnetin on the Akt/mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK)/MAPK kinase (MEK) signaling cascades, which are two important signaling pathways for endocrine therapy resistance in breast cancer.	3-methylquercetin	136-148	mechanistic target of rapamycin kinase	Homo sapiens	160-189
26502751-5	2015	In addition, isorhamnetin was observed to inhibit the Akt/mTOR and the MEK/extracellular signal-regulated kinase phosphorylation cascades.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Homo sapiens	54-57
26502751-5	2015	In addition, isorhamnetin was observed to inhibit the Akt/mTOR and the MEK/extracellular signal-regulated kinase phosphorylation cascades.	3-methylquercetin	13-25	mechanistic target of rapamycin kinase	Homo sapiens	58-62
26502751-5	2015	In addition, isorhamnetin was observed to inhibit the Akt/mTOR and the MEK/extracellular signal-regulated kinase phosphorylation cascades.	3-methylquercetin	13-25	mitogen-activated protein kinase kinase 7	Homo sapiens	71-74
26502751-7	2015	Furthermore, epidermal growth factor inhibited the effects of isorhamnetin via activation of the Akt and MEK signaling pathways.	3-methylquercetin	62-74	epidermal growth factor	Homo sapiens	13-36
26502751-7	2015	Furthermore, epidermal growth factor inhibited the effects of isorhamnetin via activation of the Akt and MEK signaling pathways.	3-methylquercetin	62-74	AKT serine/threonine kinase 1	Homo sapiens	97-100
26502751-7	2015	Furthermore, epidermal growth factor inhibited the effects of isorhamnetin via activation of the Akt and MEK signaling pathways.	3-methylquercetin	62-74	mitogen-activated protein kinase kinase 7	Homo sapiens	105-108
26502751-8	2015	These results indicate that isorhamnetin exhibits antitumor effects in breast cancer, which are mediated by the Akt and MEK signaling pathways.	3-methylquercetin	28-40	AKT serine/threonine kinase 1	Homo sapiens	112-115
26502751-8	2015	These results indicate that isorhamnetin exhibits antitumor effects in breast cancer, which are mediated by the Akt and MEK signaling pathways.	3-methylquercetin	28-40	mitogen-activated protein kinase kinase 7	Homo sapiens	120-123
26238175-4	2015	By comparison, 3-hydroxyflavone activated rat PXR, whereas 3-hydroxyflavone, galangin, quercetin, isorhamnetin, and tamarixetin activated human PXR (hPXR).	3-methylquercetin	98-110	nuclear receptor subfamily 1 group I member 2	Homo sapiens	144-147
26238175-4	2015	By comparison, 3-hydroxyflavone activated rat PXR, whereas 3-hydroxyflavone, galangin, quercetin, isorhamnetin, and tamarixetin activated human PXR (hPXR).	3-methylquercetin	98-110	nuclear receptor subfamily 1 group I member 2	Homo sapiens	149-153
26238175-5	2015	A time-resolved fluorescence resonance energy transfer competitive ligand-binding assay showed binding to the ligand-binding domain of hPXR by 3-hydroxyflavone, galangin, quercetin, isorhamnetin, and tamarixetin.	3-methylquercetin	182-194	nuclear receptor subfamily 1 group I member 2	Homo sapiens	135-139
25799286-0	2015	Isorhamnetin attenuates atherosclerosis by inhibiting macrophage apoptosis via PI3K/AKT activation and HO-1 induction.	3-methylquercetin	0-12	thymoma viral proto-oncogene 1	Mus musculus	84-87
25806943-7	2015	Isorhamnetin treatment reduced virus-induced ROS generation and blocked cytoplasmic lysosome acidification and the lipidation of microtubule associated protein1 light chain 3-B (LC3B).	3-methylquercetin	0-12	microtubule associated protein 1 light chain 3 beta	Homo sapiens	178-182
25813735-0	2015	Comparison of isorhamnetin absorption properties in total flavones of Hippophae rhamnoides L. with its pure form in a Caco-2 cell model mediated by multidrug resistance-associated protein.	3-methylquercetin	14-26	ATP binding cassette subfamily C member 3	Homo sapiens	148-187
25799286-6	2015	Iso reduced the atherosclerotic plaque size in vivo in ApoE-/- mice as assessed by oil red O, Sudan IV staining, and CD68-positive cells, and reduced macrophage apoptosis as assessed by caspase-3 and TUNEL assays in lesions.	3-methylquercetin	0-3	apolipoprotein E	Mus musculus	55-59
25799286-6	2015	Iso reduced the atherosclerotic plaque size in vivo in ApoE-/- mice as assessed by oil red O, Sudan IV staining, and CD68-positive cells, and reduced macrophage apoptosis as assessed by caspase-3 and TUNEL assays in lesions.	3-methylquercetin	0-3	caspase 3	Mus musculus	186-195
26045738-0	2015	Protective effects of isorhamnetin on apoptosis and inflammation in TNF-alpha-induced HUVECs injury.	3-methylquercetin	22-34	tumor necrosis factor	Homo sapiens	68-77
26045738-6	2015	Pretreatment with isorhamnetin significantly reduced apoptosis in TNF-alpha-treated HUVECs.	3-methylquercetin	18-30	tumor necrosis factor	Homo sapiens	66-75
26045738-7	2015	Moreover, isorhamnetin significantly attenuated TNF-alpha-induced upregulation of ICAM-1, VCAM-1, AP-1, E-selectin and NF-kappaB expression.	3-methylquercetin	10-22	tumor necrosis factor	Homo sapiens	48-57
26045738-7	2015	Moreover, isorhamnetin significantly attenuated TNF-alpha-induced upregulation of ICAM-1, VCAM-1, AP-1, E-selectin and NF-kappaB expression.	3-methylquercetin	10-22	intercellular adhesion molecule 1	Homo sapiens	82-88
26045738-7	2015	Moreover, isorhamnetin significantly attenuated TNF-alpha-induced upregulation of ICAM-1, VCAM-1, AP-1, E-selectin and NF-kappaB expression.	3-methylquercetin	10-22	vascular cell adhesion molecule 1	Homo sapiens	90-96
26045738-7	2015	Moreover, isorhamnetin significantly attenuated TNF-alpha-induced upregulation of ICAM-1, VCAM-1, AP-1, E-selectin and NF-kappaB expression.	3-methylquercetin	10-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	98-102
26045738-7	2015	Moreover, isorhamnetin significantly attenuated TNF-alpha-induced upregulation of ICAM-1, VCAM-1, AP-1, E-selectin and NF-kappaB expression.	3-methylquercetin	10-22	selectin E	Homo sapiens	104-114
26045738-9	2015	So, isorhamnetin could suppress TNF-alpha-induced apoptosis and inflammation by blocking NF-kappaB and AP-1 signaling in HUVECs, which might be one of the underlying mechanisms for treatment of coronary heart disease.	3-methylquercetin	4-16	tumor necrosis factor	Homo sapiens	32-41
26045738-9	2015	So, isorhamnetin could suppress TNF-alpha-induced apoptosis and inflammation by blocking NF-kappaB and AP-1 signaling in HUVECs, which might be one of the underlying mechanisms for treatment of coronary heart disease.	3-methylquercetin	4-16	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	103-107
25965116-0	2015	Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid beta-induced cytotoxicity and amyloid beta aggregation.	3-methylquercetin	66-78	amyloid beta precursor protein	Homo sapiens	87-99
25685784-10	2015	Taken together, our results suggest that the flavonoids myricetin, isorhamnetin, and quercetin may affect the activities of porcine CYP1A, CYP3A, and CYP2E1 in a gender-dependent manner.	3-methylquercetin	67-79	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	150-156
25965116-2	2015	In this study, N. retusa ethanol extract and its constituent isorhamnetin (IRA) protected against amyloid beta (Abeta)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells.	3-methylquercetin	61-73	amyloid beta precursor protein	Homo sapiens	98-110
25965116-2	2015	In this study, N. retusa ethanol extract and its constituent isorhamnetin (IRA) protected against amyloid beta (Abeta)-induced cytotoxicity in human neuroblastoma SH-SY5Y cells.	3-methylquercetin	61-73	amyloid beta precursor protein	Homo sapiens	112-117
25755690-9	2015	Moreover, isorhamnetin and its combinations with known anticancer drugs induced disruption of the mitochondrial membrane potential as well as activation of caspases 3, 9 and poly-(ADP-ribose) polymerase in A-549 cells.	3-methylquercetin	10-22	poly(ADP-ribose) polymerase 1	Homo sapiens	156-202
26359917-0	2015	Inhibitory Effects of Isorhamnetin on the Invasion of Human Breast Carcinoma Cells by Downregulating the Expression and Activity of Matrix Metalloproteinase-2/9.	3-methylquercetin	22-34	matrix metallopeptidase 2	Homo sapiens	132-160
26359917-4	2015	Moreover, isorhamnetin suppressed the activity and expression of MMP-2 and MMP-9, which were determined by gelatin zymography, real-time PCR, and Western blot analysis, respectively.	3-methylquercetin	10-22	matrix metallopeptidase 2	Homo sapiens	65-70
26359917-4	2015	Moreover, isorhamnetin suppressed the activity and expression of MMP-2 and MMP-9, which were determined by gelatin zymography, real-time PCR, and Western blot analysis, respectively.	3-methylquercetin	10-22	matrix metallopeptidase 9	Homo sapiens	75-80
26359917-6	2015	Further elucidation of the mechanism revealed that isorhamnetin exerted an inhibitory effect on the phosphorylation of p38 and STAT3, although it had no effect on ERK1/2 and JNK.	3-methylquercetin	51-63	mitogen-activated protein kinase 1	Homo sapiens	119-122
26359917-6	2015	Further elucidation of the mechanism revealed that isorhamnetin exerted an inhibitory effect on the phosphorylation of p38 and STAT3, although it had no effect on ERK1/2 and JNK.	3-methylquercetin	51-63	signal transducer and activator of transcription 3	Homo sapiens	127-132
26359917-7	2015	Taken together, these data demonstrated that isorhamnetin could significantly inhibit the invasion of MDA-MB-231 cells by downregulating the expression and activity of MMP-2 and MMP-9, which was potentially associated with the suppression of p38 MAPK and STAT3.	3-methylquercetin	45-57	matrix metallopeptidase 2	Homo sapiens	168-173
26359917-7	2015	Taken together, these data demonstrated that isorhamnetin could significantly inhibit the invasion of MDA-MB-231 cells by downregulating the expression and activity of MMP-2 and MMP-9, which was potentially associated with the suppression of p38 MAPK and STAT3.	3-methylquercetin	45-57	matrix metallopeptidase 9	Homo sapiens	178-183
26359917-7	2015	Taken together, these data demonstrated that isorhamnetin could significantly inhibit the invasion of MDA-MB-231 cells by downregulating the expression and activity of MMP-2 and MMP-9, which was potentially associated with the suppression of p38 MAPK and STAT3.	3-methylquercetin	45-57	mitogen-activated protein kinase 1	Homo sapiens	242-245
26359917-7	2015	Taken together, these data demonstrated that isorhamnetin could significantly inhibit the invasion of MDA-MB-231 cells by downregulating the expression and activity of MMP-2 and MMP-9, which was potentially associated with the suppression of p38 MAPK and STAT3.	3-methylquercetin	45-57	signal transducer and activator of transcription 3	Homo sapiens	255-260
25965116-0	2015	Protective effects of Nitraria retusa extract and its constituent isorhamnetin against amyloid beta-induced cytotoxicity and amyloid beta aggregation.	3-methylquercetin	66-78	amyloid beta precursor protein	Homo sapiens	125-137
24972246-9	2014	These results indicate isorhamnetin protects against the hepatotoxic effect of AA plus iron, and suggest that the AMPK pathway is involved in the mechanism underlying the beneficial effect of isorhamnetin in the liver.	3-methylquercetin	192-204	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	114-118
24972246-0	2014	AMPK activation by isorhamnetin protects hepatocytes against oxidative stress and mitochondrial dysfunction.	3-methylquercetin	19-31	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	0-4
24972246-8	2014	Experiments using CaMKK2 siRNA or its selective inhibitor, STO-609, revealed the role of CaMKK2 in the isorhamnetin-induced activation of AMPK in HepG2 cells.	3-methylquercetin	103-115	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	18-24
24972246-8	2014	Experiments using CaMKK2 siRNA or its selective inhibitor, STO-609, revealed the role of CaMKK2 in the isorhamnetin-induced activation of AMPK in HepG2 cells.	3-methylquercetin	103-115	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	89-95
24972246-8	2014	Experiments using CaMKK2 siRNA or its selective inhibitor, STO-609, revealed the role of CaMKK2 in the isorhamnetin-induced activation of AMPK in HepG2 cells.	3-methylquercetin	103-115	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	138-142
24525098-6	2014	Active transport under an ATP-dependent transport mechanism was mediated by the organic anion transporting peptide (OATP); isorhamnetin"s permeability from the apical to the basolateral side significantly decreased after estrone-3-sulfate was added (p&lt;0.01).	3-methylquercetin	123-135	solute carrier organic anion transporter family member 1A2	Homo sapiens	116-120
25183267-2	2014	Ginkgo biloba extract (GBE) and its flavonoid ingredients (quercetin, kaempferol, and isorhamnetin) could lessen the lipid accumulation associated with up-regulation of the rate-limiting enzyme, carnitine palmitoyltransferase 1A (CPT1A), in the beta-oxidation of long-chain fatty acids.	3-methylquercetin	86-98	carnitine palmitoyltransferase 1A	Homo sapiens	230-235
25183267-7	2014	The regulatory effects of GBE on CPT1A were also verified on the flavonoid ingredients quercetin, kaempferol, and isorhamnetin.	3-methylquercetin	114-126	carnitine palmitoyltransferase 1A	Homo sapiens	33-38
24913217-2	2014	We recently reported the identification of isorhamnetin as an activator of the human pregnane X receptor (PXR), a known target for abrogating inflammation in inflammatory bowel disease (IBD).	3-methylquercetin	43-55	nuclear receptor subfamily 1 group I member 2	Homo sapiens	85-104
24913217-2	2014	We recently reported the identification of isorhamnetin as an activator of the human pregnane X receptor (PXR), a known target for abrogating inflammation in inflammatory bowel disease (IBD).	3-methylquercetin	43-55	nuclear receptor subfamily 1 group I member 2	Homo sapiens	106-109
24913217-3	2014	The current study investigated the role of isorhamnetin as a putative mouse PXR activator in ameliorating chemically induced IBD.	3-methylquercetin	43-55	nuclear receptor subfamily 1, group I, member 2	Mus musculus	76-79
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	myeloperoxidase	Mus musculus	199-214
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	tumor necrosis factor	Mus musculus	230-239
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	interleukin 6	Mus musculus	244-248
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	intercellular adhesion molecule 1	Mus musculus	306-312
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	cytochrome c oxidase II, mitochondrial	Mus musculus	314-318
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	tumor necrosis factor	Mus musculus	320-329
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	interleukin 2	Mus musculus	331-335
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	interleukin 6	Mus musculus	340-344
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	373-385
24913217-4	2014	Using two different models (ulcerative colitis like and Crohn"s disease like) of experimental IBD in mice, we demonstrated that isorhamnetin abrogated inflammation through inhibiting the activity of myeloperoxidase, the levels of TNF-alpha and IL-6, the mRNA expression of proinflammatory mediators (iNOS, ICAM-1, COX2, TNF-alpha, IL-2 and IL-6) and the phosphorylation of IkappaBalpha and NF-kappaB p65.	3-methylquercetin	128-140	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	400-403
24913217-5	2014	PXR gene overexpression inhibited NF-kappaB luciferase activity, and the inhibition was potentiated by isorhamnetin treatment.	3-methylquercetin	103-115	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
24913217-7	2014	Ligand pocket-filling mutants (S247W/C284W and S247W/C284W/S208W) of human PXR weakened the effect of isorhamnetin on PXR activation.	3-methylquercetin	102-114	nuclear receptor subfamily 1 group I member 2	Homo sapiens	75-78
24913217-7	2014	Ligand pocket-filling mutants (S247W/C284W and S247W/C284W/S208W) of human PXR weakened the effect of isorhamnetin on PXR activation.	3-methylquercetin	102-114	nuclear receptor subfamily 1 group I member 2	Homo sapiens	118-121
24913217-9	2014	These results clearly demonstrated the ameliorating effect of isorhamnetin on experimental IBD via PXR-mediated up-regulation of xenobiotic metabolism and down-regulation of NF-kappaB signaling.	3-methylquercetin	62-74	nuclear receptor subfamily 1 group I member 2	Homo sapiens	99-102
24913217-10	2014	The novel findings may contribute to the effective utilization of isorhamnetin or its derivatives as a PXR ligand in the treatment of human IBD.	3-methylquercetin	66-78	nuclear receptor subfamily 1 group I member 2	Homo sapiens	103-106
24337631-0	2014	The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1.	3-methylquercetin	27-39	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	62-67
24337631-0	2014	The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1.	3-methylquercetin	27-39	heme oxygenase 1	Rattus norvegicus	128-132
24337631-3	2014	Administration of isorhamnetin decreased the number of cyclooxygenase-2 (COX-2) positive cells in rats with carrageenan-induced paw edema.	3-methylquercetin	18-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	55-71
24337631-3	2014	Administration of isorhamnetin decreased the number of cyclooxygenase-2 (COX-2) positive cells in rats with carrageenan-induced paw edema.	3-methylquercetin	18-30	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	73-78
24337631-4	2014	Isorhamnetin also suppressed lipopolysaccharide (LPS)-induced expression of COX-2 in cells.	3-methylquercetin	0-12	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	76-81
24337631-7	2014	In addition, the basal expression of heme oxygenase-1 (HO-1) was increased by isorhamnetin treatment in agreement with the increase in nuclear translocation of NF-E2-related factor-2 (Nrf2), an essential transcription factor for the regulation of HO-1 expression.	3-methylquercetin	78-90	heme oxygenase 1	Rattus norvegicus	37-53
24337631-7	2014	In addition, the basal expression of heme oxygenase-1 (HO-1) was increased by isorhamnetin treatment in agreement with the increase in nuclear translocation of NF-E2-related factor-2 (Nrf2), an essential transcription factor for the regulation of HO-1 expression.	3-methylquercetin	78-90	heme oxygenase 1	Rattus norvegicus	55-59
24337631-7	2014	In addition, the basal expression of heme oxygenase-1 (HO-1) was increased by isorhamnetin treatment in agreement with the increase in nuclear translocation of NF-E2-related factor-2 (Nrf2), an essential transcription factor for the regulation of HO-1 expression.	3-methylquercetin	78-90	NFE2 like bZIP transcription factor 2	Rattus norvegicus	160-182
24337631-7	2014	In addition, the basal expression of heme oxygenase-1 (HO-1) was increased by isorhamnetin treatment in agreement with the increase in nuclear translocation of NF-E2-related factor-2 (Nrf2), an essential transcription factor for the regulation of HO-1 expression.	3-methylquercetin	78-90	NFE2 like bZIP transcription factor 2	Rattus norvegicus	184-188
24337631-7	2014	In addition, the basal expression of heme oxygenase-1 (HO-1) was increased by isorhamnetin treatment in agreement with the increase in nuclear translocation of NF-E2-related factor-2 (Nrf2), an essential transcription factor for the regulation of HO-1 expression.	3-methylquercetin	78-90	heme oxygenase 1	Rattus norvegicus	247-251
24337631-9	2014	These results demonstrate that induction of HO-1 by isorhamnetin leads to a reduction in ROS production and its antioxidant property might contribute to the inhibition of COX-2 expression in response to inflammation.	3-methylquercetin	52-64	heme oxygenase 1	Rattus norvegicus	44-48
24337631-9	2014	These results demonstrate that induction of HO-1 by isorhamnetin leads to a reduction in ROS production and its antioxidant property might contribute to the inhibition of COX-2 expression in response to inflammation.	3-methylquercetin	52-64	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	171-176
24525098-8	2014	Among them, the MRPs (especially MRP2) were the main efflux transporters for isorhamnetin; transport from the apical to the basolateral side increased 10.8-fold after adding an MRP inhibitor (MK571).	3-methylquercetin	77-89	ATP binding cassette subfamily C member 2	Homo sapiens	33-37
24525098-8	2014	Among them, the MRPs (especially MRP2) were the main efflux transporters for isorhamnetin; transport from the apical to the basolateral side increased 10.8-fold after adding an MRP inhibitor (MK571).	3-methylquercetin	77-89	ATP binding cassette subfamily C member 1	Homo sapiens	16-19
24462958-7	2014	Water solubility was increased 22.75-, 15.15-, and 12.86-fold for isorhamnetin, kaempferol, and quercetin, respectively, in the presence of 20mg/mL IP6.	3-methylquercetin	66-78	DnaJ heat shock protein family (Hsp40) member C14	Mus musculus	145-151
24398569-0	2014	Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	66-69
24398569-0	2014	Isorhamnetin suppresses colon cancer cell growth through the PI3K-Akt-mTOR pathway.	3-methylquercetin	0-12	mechanistic target of rapamycin kinase	Homo sapiens	70-74
24398569-4	2014	It was demonstrated that isorhamnetin suppressed the proliferation of cells from all three cell lines, induced cell cycle arrest at the G2/M phase and suppressed cell proliferation by inhibiting the PI3K-Akt-mTOR pathway.	3-methylquercetin	25-37	AKT serine/threonine kinase 1	Homo sapiens	204-207
24398569-4	2014	It was demonstrated that isorhamnetin suppressed the proliferation of cells from all three cell lines, induced cell cycle arrest at the G2/M phase and suppressed cell proliferation by inhibiting the PI3K-Akt-mTOR pathway.	3-methylquercetin	25-37	mechanistic target of rapamycin kinase	Homo sapiens	208-212
24398569-5	2014	Isorhamnetin also reduced the phosphorylation levels of Akt (ser473), phosph-p70S6 kinase and phosph-4E-BP1 (t37/46) protein, and enhanced the expression of Cyclin B1 protein.	3-methylquercetin	0-12	AKT serine/threonine kinase 1	Homo sapiens	56-59
24398569-5	2014	Isorhamnetin also reduced the phosphorylation levels of Akt (ser473), phosph-p70S6 kinase and phosph-4E-BP1 (t37/46) protein, and enhanced the expression of Cyclin B1 protein.	3-methylquercetin	0-12	cyclin B1	Homo sapiens	157-166
24492725-5	2014	Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 microM in a competitive manner.	3-methylquercetin	27-39	solute carrier family 47 member 1	Homo sapiens	71-77
24211276-0	2014	Isorhamnetin protects against oxidative stress by activating Nrf2 and inducing the expression of its target genes.	3-methylquercetin	0-12	NFE2 like bZIP transcription factor 2	Homo sapiens	61-65
24211276-2	2014	However, the effects of isorhamnetin on Nrf2 activation and on the expressions of its downstream genes in hepatocytes have not been elucidated.	3-methylquercetin	24-36	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
24211276-3	2014	Here, we investigated whether isorhamnetin has the ability to activate Nrf2 and induce phase II antioxidant enzyme expression, and to determine the protective role of isorhamnetin on oxidative injury in hepatocytes.	3-methylquercetin	30-42	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
24211276-4	2014	In HepG2 cells, isorhamnetin increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, and consistently, increased antioxidant response element (ARE) reporter gene activity and the protein levels of hemeoxygenase (HO-1) and of glutamate cysteine ligase (GCL), which resulted in intracellular GSH level increases.	3-methylquercetin	16-28	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
24211276-4	2014	In HepG2 cells, isorhamnetin increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, and consistently, increased antioxidant response element (ARE) reporter gene activity and the protein levels of hemeoxygenase (HO-1) and of glutamate cysteine ligase (GCL), which resulted in intracellular GSH level increases.	3-methylquercetin	16-28	glutamate-cysteine ligase catalytic subunit	Homo sapiens	251-276
24211276-4	2014	In HepG2 cells, isorhamnetin increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, and consistently, increased antioxidant response element (ARE) reporter gene activity and the protein levels of hemeoxygenase (HO-1) and of glutamate cysteine ligase (GCL), which resulted in intracellular GSH level increases.	3-methylquercetin	16-28	glutamate-cysteine ligase catalytic subunit	Homo sapiens	278-281
24211276-5	2014	The specific role of Nrf2 in isorhamnetin-induced Nrf2 target gene expression was verified using an ARE-deletion mutant plasmid and Nrf2-knockout MEF cells.	3-methylquercetin	29-41	NFE2 like bZIP transcription factor 2	Homo sapiens	21-25
24211276-5	2014	The specific role of Nrf2 in isorhamnetin-induced Nrf2 target gene expression was verified using an ARE-deletion mutant plasmid and Nrf2-knockout MEF cells.	3-methylquercetin	29-41	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
24211276-5	2014	The specific role of Nrf2 in isorhamnetin-induced Nrf2 target gene expression was verified using an ARE-deletion mutant plasmid and Nrf2-knockout MEF cells.	3-methylquercetin	29-41	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
24211276-7	2014	In addition, Nrf2 deficiency completely blocked the ability of isorhamnetin to induce HO-1 and GCL.	3-methylquercetin	63-75	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
24211276-7	2014	In addition, Nrf2 deficiency completely blocked the ability of isorhamnetin to induce HO-1 and GCL.	3-methylquercetin	63-75	glutamate-cysteine ligase catalytic subunit	Homo sapiens	95-98
24211276-10	2014	Finally, we showed that Nrf2 deficiency blocked the ability of isorhamnetin to protect cells from injury induced by t-BHP.	3-methylquercetin	63-75	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
24211276-11	2014	Taken together, our results demonstrate that isorhamnetin is efficacious in protecting hepatocytes against oxidative stress by Nrf2 activation and in inducing the expressions of its downstream genes.	3-methylquercetin	45-57	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
24492725-6	2014	Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.	3-methylquercetin	6-18	solute carrier family 47 member 1	Homo sapiens	127-133
23441850-0	2013	Isorhamnetin inhibits Prevotella intermedia lipopolysaccharide-induced production of interleukin-6 in murine macrophages via anti-inflammatory heme oxygenase-1 induction and inhibition of nuclear factor-kappaB and signal transducer and activator of transcription 1 activation.	3-methylquercetin	0-12	heme oxygenase 1	Mus musculus	143-159
23441850-0	2013	Isorhamnetin inhibits Prevotella intermedia lipopolysaccharide-induced production of interleukin-6 in murine macrophages via anti-inflammatory heme oxygenase-1 induction and inhibition of nuclear factor-kappaB and signal transducer and activator of transcription 1 activation.	3-methylquercetin	0-12	signal transducer and activator of transcription 1	Mus musculus	214-264
23441850-3	2013	In the current study, we investigated the effect of the flavonoid isorhamnetin on the production of IL-6 in murine macrophages stimulated with lipopolysaccharide (LPS) from Prevotella intermedia, a pathogen implicated in inflammatory periodontal disease, and its mechanisms of action.	3-methylquercetin	66-78	interleukin 6	Mus musculus	100-104
23441850-11	2013	In addition, inhibition of HO-1 activity by tin protoporphyrin IX blocked the inhibitory effect of isorhamnetin on IL-6 production.	3-methylquercetin	99-111	interleukin 6	Mus musculus	115-119
23441850-14	2013	Isorhamnetin suppressed NF-kappaB signaling through inhibition of nuclear translocation and DNA binding activity of NF-kappaB p50 subunit and attenuated signal transducer and activator of transcription 1 signaling.	3-methylquercetin	0-12	signal transducer and activator of transcription 1	Mus musculus	153-203
23441850-15	2013	CONCLUSION: Although further research is required to clarify the detailed mechanism of action, we propose that isorhamnetin may contribute to blockade of the host-destructive processes mediated by IL-6 and could be a highly efficient modulator of the host response in the treatment of inflammatory periodontal disease.	3-methylquercetin	111-123	interleukin 6	Mus musculus	197-201
23824743-0	2013	Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and beta-catenin.	3-methylquercetin	44-56	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	103-106
23809009-7	2013	By comparison, 3-hydroxyflavone, galangin, datiscetin, kaempferol, quercetin, isorhamnetin and tamarixetin activated hCAR-WT, whereas none of the flavonols activated hCAR-SV25 (both SPTV and APYLT insertions).	3-methylquercetin	78-90	CXADR Ig-like cell adhesion molecule	Homo sapiens	117-121
23824743-0	2013	Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and beta-catenin.	3-methylquercetin	44-56	catenin beta 1	Homo sapiens	111-123
23824743-6	2013	Similarly, in HT-29 colon cancer cells, isorhamnetin inhibited oncogenic Src activity and beta-catenin nuclear translocation by inducing expression of csk, as verified by RNA interference knockdown of csk.	3-methylquercetin	40-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	73-76
23824743-6	2013	Similarly, in HT-29 colon cancer cells, isorhamnetin inhibited oncogenic Src activity and beta-catenin nuclear translocation by inducing expression of csk, as verified by RNA interference knockdown of csk.	3-methylquercetin	40-52	catenin beta 1	Homo sapiens	90-102
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	3-methylquercetin	0-12	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-54
23824743-6	2013	Similarly, in HT-29 colon cancer cells, isorhamnetin inhibited oncogenic Src activity and beta-catenin nuclear translocation by inducing expression of csk, as verified by RNA interference knockdown of csk.	3-methylquercetin	40-52	C-terminal Src kinase	Homo sapiens	151-154
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	3-methylquercetin	0-12	catenin beta 1	Homo sapiens	70-82
23824743-6	2013	Similarly, in HT-29 colon cancer cells, isorhamnetin inhibited oncogenic Src activity and beta-catenin nuclear translocation by inducing expression of csk, as verified by RNA interference knockdown of csk.	3-methylquercetin	40-52	C-terminal Src kinase	Homo sapiens	201-204
23824743-7	2013	Our observations suggest the chemoprotective effects of isorhamnetin in colon cancer are linked to its anti-inflammatory activities and its inhibition of oncogenic Src activity and consequential loss of nuclear beta-catenin, activities that are dependent on CSK expression.	3-methylquercetin	56-68	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	164-167
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	3-methylquercetin	0-12	C-terminal Src kinase	Homo sapiens	140-161
23824743-7	2013	Our observations suggest the chemoprotective effects of isorhamnetin in colon cancer are linked to its anti-inflammatory activities and its inhibition of oncogenic Src activity and consequential loss of nuclear beta-catenin, activities that are dependent on CSK expression.	3-methylquercetin	56-68	catenin beta 1	Homo sapiens	211-223
23824743-7	2013	Our observations suggest the chemoprotective effects of isorhamnetin in colon cancer are linked to its anti-inflammatory activities and its inhibition of oncogenic Src activity and consequential loss of nuclear beta-catenin, activities that are dependent on CSK expression.	3-methylquercetin	56-68	C-terminal Src kinase	Homo sapiens	258-261
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	3-methylquercetin	0-12	C-terminal Src kinase	Homo sapiens	163-166
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	3-methylquercetin	0-12	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	51-54
23391847-1	2013	Persicarin and isorhamnetin were isolated from Oenanthe javanica and their anticoagulant activities were examined by monitoring activated partial thromboplastin time (aPTT), prothrombin time (PT), and the activities of cell-based thrombin and activated factor X (FXa).	3-methylquercetin	15-27	coagulation factor II, thrombin	Homo sapiens	177-185
23774260-6	2013	Isorhamnetin pretreatment inhibited inducible nitric oxide synthase (iNOS) expression and NO release in LPS-stimulated cells.	3-methylquercetin	0-12	nitric oxide synthase 2	Rattus norvegicus	36-67
23774260-6	2013	Isorhamnetin pretreatment inhibited inducible nitric oxide synthase (iNOS) expression and NO release in LPS-stimulated cells.	3-methylquercetin	0-12	nitric oxide synthase 2	Rattus norvegicus	69-73
23774260-10	2013	Consistently, TNF-alpha, IL-1beta and IL-6 expression, representative NF-kappaB target genes, were almost completely prohibited by isorhamnetin.	3-methylquercetin	131-143	tumor necrosis factor	Rattus norvegicus	14-23
23774260-10	2013	Consistently, TNF-alpha, IL-1beta and IL-6 expression, representative NF-kappaB target genes, were almost completely prohibited by isorhamnetin.	3-methylquercetin	131-143	interleukin 1 beta	Rattus norvegicus	25-33
23774260-10	2013	Consistently, TNF-alpha, IL-1beta and IL-6 expression, representative NF-kappaB target genes, were almost completely prohibited by isorhamnetin.	3-methylquercetin	131-143	interleukin 6	Rattus norvegicus	38-42
23774260-11	2013	Furthermore, isorhamnetin inhibited LPS-induced JNK and AKT/IKKalpha/beta phosphorylation.	3-methylquercetin	13-25	mitogen-activated protein kinase 8	Rattus norvegicus	48-51
23774260-11	2013	Furthermore, isorhamnetin inhibited LPS-induced JNK and AKT/IKKalpha/beta phosphorylation.	3-methylquercetin	13-25	AKT serine/threonine kinase 1	Rattus norvegicus	56-59
23774260-11	2013	Furthermore, isorhamnetin inhibited LPS-induced JNK and AKT/IKKalpha/beta phosphorylation.	3-methylquercetin	13-25	component of inhibitor of nuclear factor kappa B kinase complex	Rattus norvegicus	60-68
23774260-12	2013	Our results suggest that isorhamnetin inhibited JNK, and AKT/IKKalpha/beta activation, leading to NF-kappaB inactivation, which might contribute to the inhibition of the acute inflammatory response.	3-methylquercetin	25-37	mitogen-activated protein kinase 8	Rattus norvegicus	48-51
23774260-12	2013	Our results suggest that isorhamnetin inhibited JNK, and AKT/IKKalpha/beta activation, leading to NF-kappaB inactivation, which might contribute to the inhibition of the acute inflammatory response.	3-methylquercetin	25-37	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
23774260-12	2013	Our results suggest that isorhamnetin inhibited JNK, and AKT/IKKalpha/beta activation, leading to NF-kappaB inactivation, which might contribute to the inhibition of the acute inflammatory response.	3-methylquercetin	25-37	inhibitor of nuclear factor kappa B kinase subunit beta	Rattus norvegicus	61-74
23391847-2	2013	In addition, the effects of persicarin and isorhamnetin on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were tested in tumor necrosis factor-alpha (TNF-alpha) activated human umbilical vein endothelial cells (HUVECs).	3-methylquercetin	43-55	serpin family E member 1	Homo sapiens	78-116
23391847-2	2013	In addition, the effects of persicarin and isorhamnetin on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were tested in tumor necrosis factor-alpha (TNF-alpha) activated human umbilical vein endothelial cells (HUVECs).	3-methylquercetin	43-55	serpin family E member 1	Homo sapiens	118-123
23391847-2	2013	In addition, the effects of persicarin and isorhamnetin on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were tested in tumor necrosis factor-alpha (TNF-alpha) activated human umbilical vein endothelial cells (HUVECs).	3-methylquercetin	43-55	plasminogen activator, tissue type	Homo sapiens	129-162
23391847-2	2013	In addition, the effects of persicarin and isorhamnetin on the expressions of plasminogen activator inhibitor type 1 (PAI-1) and tissue-type plasminogen activator (t-PA) were tested in tumor necrosis factor-alpha (TNF-alpha) activated human umbilical vein endothelial cells (HUVECs).	3-methylquercetin	43-55	tumor necrosis factor	Homo sapiens	185-212
23391847-3	2013	The data obtained showed that persicarin and isorhamnetin both prolonged aPTT and PT significantly and inhibited the activities of thrombin and FXa.	3-methylquercetin	45-57	coagulation factor II, thrombin	Homo sapiens	131-139
23391847-3	2013	The data obtained showed that persicarin and isorhamnetin both prolonged aPTT and PT significantly and inhibited the activities of thrombin and FXa.	3-methylquercetin	45-57	coagulation factor X	Homo sapiens	144-147
23391847-5	2013	In accordance with these anticoagulant activities, persicarin and isorhamnetin prolonged in vivo bleeding time and inhibited TNF-alpha induced PAI-1 production.	3-methylquercetin	66-78	tumor necrosis factor	Homo sapiens	125-134
23391847-5	2013	In accordance with these anticoagulant activities, persicarin and isorhamnetin prolonged in vivo bleeding time and inhibited TNF-alpha induced PAI-1 production.	3-methylquercetin	66-78	serpin family E member 1	Homo sapiens	143-148
22992727-0	2012	Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor gamma activation pathway in gastric cancer.	3-methylquercetin	0-12	peroxisome proliferator activated receptor gamma	Mus musculus	97-145
22992727-3	2012	In this study, we investigated the potential effects of isorhamnetin (IH), a 3"-O-methylated metabolite of quercetin on the peroxisome proliferator-activated receptor gamma (PPAR-gamma) signaling cascade using proteomics technology platform, GC cell lines, and xenograft mice model.	3-methylquercetin	56-68	peroxisome proliferator activated receptor gamma	Mus musculus	124-172
22992727-3	2012	In this study, we investigated the potential effects of isorhamnetin (IH), a 3"-O-methylated metabolite of quercetin on the peroxisome proliferator-activated receptor gamma (PPAR-gamma) signaling cascade using proteomics technology platform, GC cell lines, and xenograft mice model.	3-methylquercetin	56-68	peroxisome proliferator activated receptor gamma	Mus musculus	174-184
22846602-6	2012	The aim of the present study was to investigate the effects of supraphysiological concentrations of quercetin and its methyl and glucuronide metabolites (3"-O-methyl-quercetin and quercetin-3-O-glucuronide) on activation of AMPK and eNOS in human aortic endothelial cells (HAECs) and endothelial function in isolated aortic rings from C57BL mice.	3-methylquercetin	154-175	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	224-228
23162896-0	2012	[Effects of isorhamnetin on CYP3A4 and herb-drug interaction].	3-methylquercetin	12-24	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-34
22988926-10	2012	In HepG2 cells, GBE and its ingredients, quercetin, kaempferol and isorhamnetin, could decrease the cellular triglyceride content and upregulate the expression and total activity of CPT1A, respectively.	3-methylquercetin	67-79	carnitine palmitoyltransferase 1A	Homo sapiens	182-187
23162896-1	2012	The study is to report the investigation of the effects of isorhamnetin on CYP3A4 and herb-drug interaction.	3-methylquercetin	59-71	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81
23162896-2	2012	A reporter gene assay is used to test pregnane X receptor transactivation action, qRT-PCR and a luminescence-based assay were applied to determine mRNA induction and enzyme activity of CYP3A4 after isorhamnetin treatment.	3-methylquercetin	198-210	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	185-191
23162896-4	2012	Isorhamnetin at 1, 10 and 25 micromol x L(-1) transactivated the CYP3A4 reporter construct and upregulated CYP3A4 mRNA as well in a dose-dependent manner.	3-methylquercetin	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-71
23162896-4	2012	Isorhamnetin at 1, 10 and 25 micromol x L(-1) transactivated the CYP3A4 reporter construct and upregulated CYP3A4 mRNA as well in a dose-dependent manner.	3-methylquercetin	0-12	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	107-113
23162896-6	2012	In conclusion, activation of PXR by isorhamnetin played a role in the upregulation of CYP3A4 mRNA.	3-methylquercetin	36-48	nuclear receptor subfamily 1 group I member 2	Homo sapiens	29-32
23162896-6	2012	In conclusion, activation of PXR by isorhamnetin played a role in the upregulation of CYP3A4 mRNA.	3-methylquercetin	36-48	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
21341175-5	2011	Four flavonoids (flavone, isorhamnetin, daidzein, and genistein) inhibited significantly LPS-induced COX-2 expression, while mPGES-1 expression was downregulated by kaempferol and isorhamnetin.	3-methylquercetin	26-38	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
22489690-8	2012	Expression of phospho-Akt and p53 showed no detectable change during the first 48 h. Pretreatment with the NF-kappaB inhibitor MG132 before exposure to isorhamnetin blocked the nuclear accumulation of p50 and p65, thereby inhibiting cell proliferation.	3-methylquercetin	152-164	AKT serine/threonine kinase 1	Homo sapiens	22-25
22489690-8	2012	Expression of phospho-Akt and p53 showed no detectable change during the first 48 h. Pretreatment with the NF-kappaB inhibitor MG132 before exposure to isorhamnetin blocked the nuclear accumulation of p50 and p65, thereby inhibiting cell proliferation.	3-methylquercetin	152-164	nuclear factor kappa B subunit 1	Homo sapiens	201-204
22489690-8	2012	Expression of phospho-Akt and p53 showed no detectable change during the first 48 h. Pretreatment with the NF-kappaB inhibitor MG132 before exposure to isorhamnetin blocked the nuclear accumulation of p50 and p65, thereby inhibiting cell proliferation.	3-methylquercetin	152-164	RELA proto-oncogene, NF-kB subunit	Homo sapiens	209-212
22489690-9	2012	These results show that during early exposure of Eca-109 cells to isorhamnetin, the NF-kappaB signaling pathway is activated and COX-2 expression increases, and this increase in expression partially inhibits isorhamnetin-induced apoptosis.	3-methylquercetin	66-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
22489690-9	2012	These results show that during early exposure of Eca-109 cells to isorhamnetin, the NF-kappaB signaling pathway is activated and COX-2 expression increases, and this increase in expression partially inhibits isorhamnetin-induced apoptosis.	3-methylquercetin	208-220	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134
21341175-5	2011	Four flavonoids (flavone, isorhamnetin, daidzein, and genistein) inhibited significantly LPS-induced COX-2 expression, while mPGES-1 expression was downregulated by kaempferol and isorhamnetin.	3-methylquercetin	180-192	prostaglandin E synthase	Mus musculus	125-132
21341175-7	2011	The results add to our knowledge of the anti-inflammatory actions of flavonoids and introduce kaempferol and isorhamnetin as compounds capable of downregulating the expression of mPGES-1.	3-methylquercetin	109-121	prostaglandin E synthase	Mus musculus	179-186
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	0-21	intercellular adhesion molecule 1	Homo sapiens	133-166
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	0-21	intercellular adhesion molecule 1	Homo sapiens	168-174
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	0-21	latexin	Homo sapiens	260-263
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	0-21	selectin E	Homo sapiens	279-289
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	0-21	vascular cell adhesion molecule 1	Homo sapiens	398-431
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	0-21	vascular cell adhesion molecule 1	Homo sapiens	433-439
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	23-44	intercellular adhesion molecule 1	Homo sapiens	133-166
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	23-44	intercellular adhesion molecule 1	Homo sapiens	168-174
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	23-44	latexin	Homo sapiens	260-263
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	23-44	selectin E	Homo sapiens	279-289
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	23-44	vascular cell adhesion molecule 1	Homo sapiens	398-431
21571063-6	2011	3"-O-Methyl-quercetin, 4"-O-methyl-quercetin, and their parent aglycone compound, quercetin, all effectively inhibited expression of intercellular adhesion molecule-1 (ICAM-1) with IC(50) values (concentration required for 50% inhibition) of 8.0, 5.0, and 4.4 muM, respectively; E-selectin expression was suppressed to a somewhat lesser but still significant degree by all three compounds, whereas vascular cell adhesion molecule-1 (VCAM-1) was not affected.	3-methylquercetin	23-44	vascular cell adhesion molecule 1	Homo sapiens	433-439
22761636-0	2012	Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor.	3-methylquercetin	0-12	nerve growth factor	Rattus norvegicus	141-160
22761636-5	2012	Although isorhamnetin by itself did not show significant inductive effect on neurite outgrowth of cultured PC12 cells, the application of isorhamnetin potentiated the nerve growth factor- (NGF-)induced neurite outgrowth.	3-methylquercetin	138-150	nerve growth factor	Rattus norvegicus	167-186
21413092-0	2011	Persicaria hydropiper (L.) spach and its flavonoid components, isoquercitrin and isorhamnetin, activate the Wnt/beta-catenin pathway and inhibit adipocyte differentiation of 3T3-L1 cells.	3-methylquercetin	81-93	catenin (cadherin associated protein), beta 1	Mus musculus	112-124
21413092-7	2011	Isoquercitrin and isorhamnetin, constituents of P. hydropiper, also activated Wnt/beta-catenin signaling and suppressed the differentiation of 3T3-L1 cells.	3-methylquercetin	18-30	catenin (cadherin associated protein), beta 1	Mus musculus	82-94
21463675-12	2011	The isolated compounds showed estrogenic activity but quercetin, kaempferol and isorhamnetin showed more potent ERbeta agonist activity.	3-methylquercetin	80-92	estrogen receptor 2	Rattus norvegicus	112-118
21330379-0	2011	Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. 3"-Methoxy-3,4",5,7-tetrahydroxyflavone (isorhamnetin) is a plant flavonoid that occurs in fruits and medicinal herbs.	3-methylquercetin	0-12	mitogen-activated protein kinase kinase 1	Homo sapiens	65-69
21330379-10	2011	Overall, these results indicate that isorhamnetin has potent anticancer activity and it primarily targets MEK and PI3-K, which might contribute to the chemopreventive potential of certain foods.	3-methylquercetin	37-49	mitogen-activated protein kinase kinase 7	Homo sapiens	106-109
21330379-0	2011	Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. 3"-Methoxy-3,4",5,7-tetrahydroxyflavone (isorhamnetin) is a plant flavonoid that occurs in fruits and medicinal herbs.	3-methylquercetin	81-120	mitogen-activated protein kinase kinase 1	Homo sapiens	65-69
21330379-0	2011	Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. 3"-Methoxy-3,4",5,7-tetrahydroxyflavone (isorhamnetin) is a plant flavonoid that occurs in fruits and medicinal herbs.	3-methylquercetin	122-134	mitogen-activated protein kinase kinase 1	Homo sapiens	65-69
21330379-4	2011	Isorhamnetin attenuated EGF-induced COX-2 expression in JB6 and A431 cells.	3-methylquercetin	0-12	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	36-41
21330379-6	2011	The EGF-induced phosphorylation of extracellular signal-regulated kinases, p90 and p70 ribosomal S6 kinases, and Akt was suppressed by isorhamnetin.	3-methylquercetin	135-147	cellular inhibitor of PP2A	Homo sapiens	75-78
21330379-6	2011	The EGF-induced phosphorylation of extracellular signal-regulated kinases, p90 and p70 ribosomal S6 kinases, and Akt was suppressed by isorhamnetin.	3-methylquercetin	135-147	AKT serine/threonine kinase 1	Homo sapiens	83-116
21330379-7	2011	In vitro and ex vivo kinase assay data showed that isorhamnetin inhibited the kinase activity of MAP (mitogen-activated protein)/ERK (extracellular signal regulated kinase) kinase (MEK) 1 and PI3-K (phosphoinositide 3-kinase) and the inhibition was due to direct binding with isorhamnetin.	3-methylquercetin	51-63	mitogen-activated protein kinase 1	Homo sapiens	129-132
21330379-7	2011	In vitro and ex vivo kinase assay data showed that isorhamnetin inhibited the kinase activity of MAP (mitogen-activated protein)/ERK (extracellular signal regulated kinase) kinase (MEK) 1 and PI3-K (phosphoinositide 3-kinase) and the inhibition was due to direct binding with isorhamnetin.	3-methylquercetin	51-63	mitogen-activated protein kinase kinase 1	Homo sapiens	134-187
21330379-7	2011	In vitro and ex vivo kinase assay data showed that isorhamnetin inhibited the kinase activity of MAP (mitogen-activated protein)/ERK (extracellular signal regulated kinase) kinase (MEK) 1 and PI3-K (phosphoinositide 3-kinase) and the inhibition was due to direct binding with isorhamnetin.	3-methylquercetin	51-63	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	199-224
21330379-7	2011	In vitro and ex vivo kinase assay data showed that isorhamnetin inhibited the kinase activity of MAP (mitogen-activated protein)/ERK (extracellular signal regulated kinase) kinase (MEK) 1 and PI3-K (phosphoinositide 3-kinase) and the inhibition was due to direct binding with isorhamnetin.	3-methylquercetin	276-288	mitogen-activated protein kinase 1	Homo sapiens	129-132
21330379-8	2011	Notably, isorhamnetin bound directly to MEK1 in an ATP-noncompetitive manner and to PI3-K in an ATP-competitive manner.	3-methylquercetin	9-21	mitogen-activated protein kinase kinase 1	Homo sapiens	40-44
20579867-2	2011	Quercetin and isorhamnetin but not Q3G significantly decreased mRNA and protein levels of tumor necrosis factor alpha.	3-methylquercetin	14-26	tumor necrosis factor	Mus musculus	90-117
20579867-5	2011	Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation.	3-methylquercetin	46-58	heme oxygenase 1	Mus musculus	94-110
20579867-5	2011	Anti-inflammatory properties of quercetin and isorhamnetin were accompanied by an increase in heme oxygenase 1 protein levels, a downstream target of the transcription factor Nrf2, known to antagonize chronic inflammation.	3-methylquercetin	46-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	175-179
20571914-3	2010	Among the 20 flavonoids we examined, we found that isorhamnetin and luteolin had the best protective effects against H(2)O(2) or SIN-1-induced cytotoxicity in SH-SY5Y cells.	3-methylquercetin	51-63	MAPK associated protein 1	Homo sapiens	129-134
20696580-6	2010	In particular, methoxy types of flavones and flavonols such as chrysoeriol and isorhamnetin showed strong and selective inhibition against CYP1B1.	3-methylquercetin	79-91	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	139-145
20696580-8	2010	The results suggested that chrysoeriol and isorhamnetin fit well into the active site of CYP1B1, but do not fit into the active site of CYP1A2 and 1A1 because of steric collisions between the methoxy substituent of these methoxyflavonoids and Ser-122 in CYP1A1 and Thr-124 in CYP1A2.	3-methylquercetin	43-55	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	89-95
20696580-8	2010	The results suggested that chrysoeriol and isorhamnetin fit well into the active site of CYP1B1, but do not fit into the active site of CYP1A2 and 1A1 because of steric collisions between the methoxy substituent of these methoxyflavonoids and Ser-122 in CYP1A1 and Thr-124 in CYP1A2.	3-methylquercetin	43-55	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	254-260
20696580-8	2010	The results suggested that chrysoeriol and isorhamnetin fit well into the active site of CYP1B1, but do not fit into the active site of CYP1A2 and 1A1 because of steric collisions between the methoxy substituent of these methoxyflavonoids and Ser-122 in CYP1A1 and Thr-124 in CYP1A2.	3-methylquercetin	43-55	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	276-282
20571914-5	2010	Moreover, isorhamnetin and luteolin treatment downregulated the expression of inducible nitric oxide synthase (iNOS), and oxidative stress was significantly inhibited by an iNOS inhibitor in SH-SY5Y cells exposed to simulated microgravity (SMG).	3-methylquercetin	10-22	nitric oxide synthase 2	Homo sapiens	78-109
20571914-5	2010	Moreover, isorhamnetin and luteolin treatment downregulated the expression of inducible nitric oxide synthase (iNOS), and oxidative stress was significantly inhibited by an iNOS inhibitor in SH-SY5Y cells exposed to simulated microgravity (SMG).	3-methylquercetin	10-22	nitric oxide synthase 2	Homo sapiens	111-115
20571914-5	2010	Moreover, isorhamnetin and luteolin treatment downregulated the expression of inducible nitric oxide synthase (iNOS), and oxidative stress was significantly inhibited by an iNOS inhibitor in SH-SY5Y cells exposed to simulated microgravity (SMG).	3-methylquercetin	10-22	nitric oxide synthase 2	Homo sapiens	173-177
20097210-0	2010	Isorhamnetin-induced anti-adipogenesis is mediated by stabilization of beta-catenin protein.	3-methylquercetin	0-12	catenin (cadherin associated protein), beta 1	Mus musculus	71-83
20484173-5	2010	Intake of flavonols, especially of isorhamnetin, kaempferol, and quercetin, was inversely associated with serum IL-6 concentrations (highest versus lowest flavonol intake quartile, 1.80 versus 2.20 pg/mL) and high-risk (OR, 0.51; 95% CI, 0.26-0.98) and advanced adenoma recurrence (OR, 0.17; 95% CI, 0.06-0.50).	3-methylquercetin	35-47	interleukin 6	Homo sapiens	112-116
20097210-6	2010	Additionally, when the effects of Wnt antagonists that promote adipogenesis were evaluated, isorhamnetin was found to down-regulate the mRNA levels of sFRP1 and Dkk1, but had no effect on the mRNA levels of sFRP2, sFRP3, sFRP4 and Dkk3.	3-methylquercetin	92-104	secreted frizzled-related protein 1	Mus musculus	151-156
20097210-6	2010	Additionally, when the effects of Wnt antagonists that promote adipogenesis were evaluated, isorhamnetin was found to down-regulate the mRNA levels of sFRP1 and Dkk1, but had no effect on the mRNA levels of sFRP2, sFRP3, sFRP4 and Dkk3.	3-methylquercetin	92-104	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	161-165
20097210-6	2010	Additionally, when the effects of Wnt antagonists that promote adipogenesis were evaluated, isorhamnetin was found to down-regulate the mRNA levels of sFRP1 and Dkk1, but had no effect on the mRNA levels of sFRP2, sFRP3, sFRP4 and Dkk3.	3-methylquercetin	92-104	frizzled-related protein	Mus musculus	214-219
20097210-6	2010	Additionally, when the effects of Wnt antagonists that promote adipogenesis were evaluated, isorhamnetin was found to down-regulate the mRNA levels of sFRP1 and Dkk1, but had no effect on the mRNA levels of sFRP2, sFRP3, sFRP4 and Dkk3.	3-methylquercetin	92-104	secreted frizzled-related protein 4	Mus musculus	221-226
20097210-6	2010	Additionally, when the effects of Wnt antagonists that promote adipogenesis were evaluated, isorhamnetin was found to down-regulate the mRNA levels of sFRP1 and Dkk1, but had no effect on the mRNA levels of sFRP2, sFRP3, sFRP4 and Dkk3.	3-methylquercetin	92-104	dickkopf WNT signaling pathway inhibitor 3	Mus musculus	231-235
20097210-8	2010	Furthermore, isorhamnetin increased the protein levels of beta-catenin, an effector molecule of Wnt signaling, but had no effect on the mRNA levels of beta-catenin.	3-methylquercetin	13-25	catenin (cadherin associated protein), beta 1	Mus musculus	58-70
20097210-9	2010	The phosphorylation level of GSK 3beta was also increased by isorhamnetin.	3-methylquercetin	61-73	glycogen synthase kinase 3 beta	Mus musculus	29-38
20097210-12	2010	SIGNIFICANCE: Our results indicate that isorhamnetin inhibits the adipogenic differentiation of hAMSCs and that its mechanisms are mediated by the stabilization of beta-catenin.	3-methylquercetin	40-52	catenin (cadherin associated protein), beta 1	Mus musculus	164-176
19222219-6	2009	Increased CA, [Ca2+]i, and ROS levels, but lower caspase-3 activities, were obtained upon treatment with 50 microM isorhamnetin or isosakuranetin.	3-methylquercetin	115-127	caspase 3	Rattus norvegicus	49-58
20228421-8	2010	In mice, unlike in humans, a large proportion of quercetin is methylated to isorhamnetin which exhibits, according to our reporter gene data in cultured liver cells, a potent PON1 inducing activity.	3-methylquercetin	76-88	paraoxonase 1	Homo sapiens	175-179
19794518-7	2009	In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene.	3-methylquercetin	109-121	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	146-152
19794518-7	2009	In contrast, quercetin increased CYP1B1 and CYP1A1 gene expression and activated AhR, whereas kaempferol and isorhamnetin suppressed constitutive CYP1B1 expression and antagonized AhR activation by benzo[a]pyrene.	3-methylquercetin	109-121	aryl hydrocarbon receptor	Homo sapiens	180-183
18948972-3	2009	In this study, we show that isorhamnetin inhibits adipocyte differentiation, as evidenced by reduced triglyceride (TG) accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity.	3-methylquercetin	28-40	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	136-170
18948972-3	2009	In this study, we show that isorhamnetin inhibits adipocyte differentiation, as evidenced by reduced triglyceride (TG) accumulation and glycerol-3-phosphate dehydrogenase (GPDH) activity.	3-methylquercetin	28-40	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	172-176
18948972-4	2009	At the molecular level, the mRNA expression levels of peroxidase proliferator-activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), which are the major adipogenic transcription factors, were markedly reduced by isorhamnetin.	3-methylquercetin	251-263	peroxisome proliferator activated receptor gamma	Mus musculus	54-102
18948972-4	2009	At the molecular level, the mRNA expression levels of peroxidase proliferator-activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), which are the major adipogenic transcription factors, were markedly reduced by isorhamnetin.	3-methylquercetin	251-263	peroxisome proliferator activated receptor gamma	Mus musculus	104-114
18948972-4	2009	At the molecular level, the mRNA expression levels of peroxidase proliferator-activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), which are the major adipogenic transcription factors, were markedly reduced by isorhamnetin.	3-methylquercetin	251-263	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	120-156
18948972-4	2009	At the molecular level, the mRNA expression levels of peroxidase proliferator-activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), which are the major adipogenic transcription factors, were markedly reduced by isorhamnetin.	3-methylquercetin	251-263	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	158-169
18948972-6	2009	Moreover, the mRNA levels of PPAR-gamma target genes such as lipoprotein lipase (LPL), CD36, aP2, and liver X receptor-alpha (LXR-alpha) were downregulated by isorhamnetin.	3-methylquercetin	159-171	peroxisome proliferator activated receptor gamma	Mus musculus	29-39
18948972-8	2009	Taken together, these results indicate that isorhamnetin inhibits adipogenesis through downregulation of PPAR-gamma and C/EBP-alpha.	3-methylquercetin	44-56	peroxisome proliferator activated receptor gamma	Mus musculus	105-115
18948972-8	2009	Taken together, these results indicate that isorhamnetin inhibits adipogenesis through downregulation of PPAR-gamma and C/EBP-alpha.	3-methylquercetin	44-56	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	120-131
18617322-0	2008	Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis.	3-methylquercetin	53-65	caspase 9	Mus musculus	26-35
18436224-2	2009	We have investigated the effects of quercetin and its methylated metabolite isorhamnetin (1-10microM) on endothelial dysfunction and superoxide (O(2*)(-)) production induced by endothelin-1 (ET-1, 10nM).	3-methylquercetin	76-88	endothelin 1	Homo sapiens	177-189
18436224-3	2009	ET-1 increased the contractile response induced by phenylephrine and reduced the relaxant responses to acetylcholine in phenylephrine contracted intact aorta, and these effects were prevented by co-incubation with quercetin, isorhamnetin or chelerythrine (protein kinase C (PKC) inhibitor).	3-methylquercetin	225-237	endothelin 1	Homo sapiens	0-4
18617322-5	2008	Western blot analyses revealed increased cleavage of caspase-3, and caspase-9 and PARP and increased cytosolic cytochrome C in isorhamnetin-treated cells.	3-methylquercetin	127-139	caspase 3	Mus musculus	53-62
17374653-0	2007	Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.	3-methylquercetin	14-26	neutrophil cytosolic factor 1	Rattus norvegicus	105-112
18436224-9	2009	Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin.	3-methylquercetin	197-209	endothelin 1	Homo sapiens	43-47
18954533-6	2008	RESULTS: The permeability ratio (absorptive permeability/secretive permeability) of isorhamnetin across human MDR1 cDNA transfected MDCKII cells, Caco-2 cells and wild-type MDCKII cells are 0.25+/-0.02, 0.74+/-0.05, and 1.41+/-0.06, respectively.	3-methylquercetin	84-96	ATP binding cassette subfamily B member 1	Homo sapiens	110-114
18954533-7	2008	This result proved the role of P-gp in the cell efflux of isorhamnetin.	3-methylquercetin	58-70	phosphoglycolate phosphatase	Homo sapiens	31-35
17374653-0	2007	Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta.	3-methylquercetin	14-26	angiotensinogen	Rattus norvegicus	124-138
17374653-2	2007	We analyzed the effects of quercetin and its methylated metabolite isorhamnetin on the aortic endothelial dysfunction induced by incubation with angiotensin II (AngII) in vitro for 6 h. AngII diminished the relaxant responses to acetylcholine in phenylephrine-contracted aorta.	3-methylquercetin	67-79	angiotensinogen	Rattus norvegicus	145-159
17374653-2	2007	We analyzed the effects of quercetin and its methylated metabolite isorhamnetin on the aortic endothelial dysfunction induced by incubation with angiotensin II (AngII) in vitro for 6 h. AngII diminished the relaxant responses to acetylcholine in phenylephrine-contracted aorta.	3-methylquercetin	67-79	angiotensinogen	Rattus norvegicus	161-166
17374653-4	2007	At 6 h, AngII induced a marked increase in O(2)(-) production as measured by dihydroethidium fluorescence, which was prevented by quercetin and isorhamnetin.	3-methylquercetin	144-156	angiotensinogen	Rattus norvegicus	8-13
17374653-7	2007	p47(phox) overexpression was also prevented by quercetin and isorhamnetin.	3-methylquercetin	61-73	NSFL1 cofactor	Rattus norvegicus	0-3
17374653-8	2007	Taken together, these results show for the first time, to our knowledge, that quercetin and isorhamnetin prevent AngII-induced endothelial dysfunction by inhibiting the overexpression of p47(phox) and the subsequent increased O(2)(-) production, resulting in increased nitric oxide bioavailability.	3-methylquercetin	92-104	angiotensinogen	Rattus norvegicus	113-118
17374653-8	2007	Taken together, these results show for the first time, to our knowledge, that quercetin and isorhamnetin prevent AngII-induced endothelial dysfunction by inhibiting the overexpression of p47(phox) and the subsequent increased O(2)(-) production, resulting in increased nitric oxide bioavailability.	3-methylquercetin	92-104	NSFL1 cofactor	Rattus norvegicus	187-190
16226778-0	2006	Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.	3-methylquercetin	101-113	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	165-171
16963021-0	2006	Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK.	3-methylquercetin	0-12	mitogen-activated protein kinase 14	Homo sapiens	83-90
16963021-9	2006	Isorhamnetin pretreatment inhibited the ox-LDL-induced downregulation of eNOS, upregulation of lectin-like ox-LDL receptor-1, phosphorylation of the p38MAPK and translocation of NF-kappaB.	3-methylquercetin	0-12	nitric oxide synthase 3	Homo sapiens	73-77
16963021-9	2006	Isorhamnetin pretreatment inhibited the ox-LDL-induced downregulation of eNOS, upregulation of lectin-like ox-LDL receptor-1, phosphorylation of the p38MAPK and translocation of NF-kappaB.	3-methylquercetin	0-12	mitogen-activated protein kinase 14	Homo sapiens	149-156
16963021-9	2006	Isorhamnetin pretreatment inhibited the ox-LDL-induced downregulation of eNOS, upregulation of lectin-like ox-LDL receptor-1, phosphorylation of the p38MAPK and translocation of NF-kappaB.	3-methylquercetin	0-12	nuclear factor kappa B subunit 1	Homo sapiens	178-187
17368593-4	2007	Inhibition on proliferation by isorhamnetin was detected by trypan blue exclusion assay, clone formation test, immunocytochemical assay of PCNA and (3)H-thymidine uptake analysis.	3-methylquercetin	31-43	proliferating cell nuclear antigen	Homo sapiens	139-143
17368593-11	2007	To explore the possible molecular mechanisms that underlie the growth inhibition and apoptosis stimulatory effects of isorhamnetin, the expressions of six proliferation- and death-related genes were detected by FCM.	3-methylquercetin	118-130	nucleolar protein 3	Homo sapiens	211-214
16226778-9	2006	Overall, our novel findings indicate that G. biloba extract and the flavonol aglycones isorhamnetin, kaempferol, and quercetin preferentially inhibit the in vitro catalytic activity of human CYP1B1.	3-methylquercetin	87-99	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	191-197
15905060-13	2005	The validated method was applied to quantify quercetin, kaempferol and isorhamnetin in human breast cancer Bcap37 and Bcap37/MDR1 cells.	3-methylquercetin	71-83	prohibitin 2	Homo sapiens	107-113
16213685-11	2006	In conclusion, 3-MQ may exert its anti-inflammatory effect through the inhibition of iNOS DNA transcription.	3-methylquercetin	15-19	nitric oxide synthase 2, inducible	Mus musculus	85-89
15905060-13	2005	The validated method was applied to quantify quercetin, kaempferol and isorhamnetin in human breast cancer Bcap37 and Bcap37/MDR1 cells.	3-methylquercetin	71-83	prohibitin 2	Homo sapiens	118-124
15905060-13	2005	The validated method was applied to quantify quercetin, kaempferol and isorhamnetin in human breast cancer Bcap37 and Bcap37/MDR1 cells.	3-methylquercetin	71-83	ATP binding cassette subfamily B member 1	Homo sapiens	125-129
15643544-0	2004	Suppressive effects of 3-O-methylquercetin on ovalbumin-induced airway hyperresponsiveness.	3-methylquercetin	23-42	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	46-55
15749994-8	2005	When intestinal Bcrp1 was inhibited by FTC in Mrp2-deficient rats, total plasma concentrations of quercetin and its methylated metabolite isorhamnetin after 30 min of perfusion were more than twice that of controls (12.3 +/- 1.5 versus 5.6 +/- 1.3 muM; p &lt; 0.01), whereas uptake of free quercetin from the intestinal lumen was not affected.	3-methylquercetin	138-150	ATP binding cassette subfamily G member 2	Rattus norvegicus	16-21
15749994-8	2005	When intestinal Bcrp1 was inhibited by FTC in Mrp2-deficient rats, total plasma concentrations of quercetin and its methylated metabolite isorhamnetin after 30 min of perfusion were more than twice that of controls (12.3 +/- 1.5 versus 5.6 +/- 1.3 muM; p &lt; 0.01), whereas uptake of free quercetin from the intestinal lumen was not affected.	3-methylquercetin	138-150	fucosyltransferase 2	Rattus norvegicus	39-42
15788228-2	2005	The synergistic effects of flavonoids and ascorbate on DNA degradation induced by the BLM-Fe complex were observed to be greater with flavonoids such as isorhamnetin, kaempferol and morin, which accelerated oxidation more markedly in the presence, than in the absence of BLM.	3-methylquercetin	153-165	BLM RecQ like helicase	Homo sapiens	86-89
15788228-2	2005	The synergistic effects of flavonoids and ascorbate on DNA degradation induced by the BLM-Fe complex were observed to be greater with flavonoids such as isorhamnetin, kaempferol and morin, which accelerated oxidation more markedly in the presence, than in the absence of BLM.	3-methylquercetin	153-165	BLM RecQ like helicase	Homo sapiens	271-274
15643544-7	2004	In addition, 3-MQ (3 micromol/kg, i. p.) significantly decreased the secretion of TNF-alpha, and at the highest dose (30 micromol/kg, i. p.) even decreased the secretions of IL-4, IL-5, and TNF-alpha.	3-methylquercetin	13-17	tumor necrosis factor	Cavia porcellus	82-91
15643544-7	2004	In addition, 3-MQ (3 micromol/kg, i. p.) significantly decreased the secretion of TNF-alpha, and at the highest dose (30 micromol/kg, i. p.) even decreased the secretions of IL-4, IL-5, and TNF-alpha.	3-methylquercetin	13-17	interleukin-4	Cavia porcellus	174-178
15643544-7	2004	In addition, 3-MQ (3 micromol/kg, i. p.) significantly decreased the secretion of TNF-alpha, and at the highest dose (30 micromol/kg, i. p.) even decreased the secretions of IL-4, IL-5, and TNF-alpha.	3-methylquercetin	13-17	interleukin-5	Cavia porcellus	180-184
15643544-7	2004	In addition, 3-MQ (3 micromol/kg, i. p.) significantly decreased the secretion of TNF-alpha, and at the highest dose (30 micromol/kg, i. p.) even decreased the secretions of IL-4, IL-5, and TNF-alpha.	3-methylquercetin	13-17	tumor necrosis factor	Cavia porcellus	190-199
10718659-0	2000	High-performance liquid chromatographic determination of quercetin and isorhamnetin in rat tissues using beta-glucuronidase and acid hydrolysis.	3-methylquercetin	71-83	glucuronidase, beta	Rattus norvegicus	105-123
12086683-8	2002	Incubation with 3,5-dinitrocatechol (10 microM), a catechol-O-methyltransferase (COMT) inhibitor, prevented the conversion of quercetin to 3"-O-methyl quercetin.	3-methylquercetin	139-160	catechol-O-methyltransferase	Rattus norvegicus	51-79
12086683-8	2002	Incubation with 3,5-dinitrocatechol (10 microM), a catechol-O-methyltransferase (COMT) inhibitor, prevented the conversion of quercetin to 3"-O-methyl quercetin.	3-methylquercetin	139-160	catechol-O-methyltransferase	Rattus norvegicus	81-85