PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9764831-1	1998	Human dermal papilla cells (HDPC) express mRNA for the key enzymes for de novo synthesis/recycling and regulation of the pterin (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH4).	6bh4	172-176	decapping mRNA 2	Homo sapiens	28-32
9764831-2	1998	HDPC had significantly higher enzyme activities and 6BH4 levels in a comparative study with dermal fibroblasts, epidermal melanocytes, and keratinocytes under in vitro conditions.	6bh4	52-56	decapping mRNA 2	Homo sapiens	0-4
9764831-4	1998	These results suggested that HDPC driven 6BH4 synthesis could be of major functional importance in the hair cycle.	6bh4	41-45	decapping mRNA 2	Homo sapiens	29-33
9764831-6	1998	These data revealed a significantly increased de novo synthesis for 6BH4 via GTP-cyclohydrolase I concomitant with high levels of 6BH4, and the induction of phenylalanine hydroxylase activities during the telogen/early anagen stage (days 0-1).	6bh4	68-72	GTP cyclohydrolase 1	Homo sapiens	77-97
9740249-3	1998	This study unveils a defective (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH4) de novo synthesis/recycling for this cofactor in HPS, where activities of the key enzyme GTP-cyclohydrolase I are in the normal range, but total biopterin levels are significantly decreased in homozygotes (n = 5) compared with unaffected controls (n = 4) (p = 0.00001).	6bh4	75-79	GTP cyclohydrolase 1	Homo sapiens	170-190
9740249-6	1998	Thioredoxin/thioredoxin reductase can directly control the redox status of 6BH4.	6bh4	75-79	thioredoxin	Homo sapiens	0-11
9740249-6	1998	Thioredoxin/thioredoxin reductase can directly control the redox status of 6BH4.	6bh4	75-79	peroxiredoxin 5	Homo sapiens	12-33
18177348-3	2008	The central role of tyrosinase as the key enzyme in initiation of melanogenesis has been closely associated with the 6BH4 dependent phenylalanine hydroxylase (PAH) and tyrosine hydroxylase isoform I (THI) providing evidence for an old concept of the three enzyme theory in the initiation of the pigmentation process.	6bh4	117-121	tyrosinase	Homo sapiens	20-30
18177348-3	2008	The central role of tyrosinase as the key enzyme in initiation of melanogenesis has been closely associated with the 6BH4 dependent phenylalanine hydroxylase (PAH) and tyrosine hydroxylase isoform I (THI) providing evidence for an old concept of the three enzyme theory in the initiation of the pigmentation process.	6bh4	117-121	phenylalanine hydroxylase	Homo sapiens	132-157
16778797-2	2006	The rate-limiting step of 6BH4 de novo synthesis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulatory protein (GFRP), where binding of L-phenylalanine to GFRP increases enzyme activities, while 6BH4 exerts the opposite effect.	6bh4	26-30	GTP cyclohydrolase 1	Homo sapiens	66-111
16778797-2	2006	The rate-limiting step of 6BH4 de novo synthesis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulatory protein (GFRP), where binding of L-phenylalanine to GFRP increases enzyme activities, while 6BH4 exerts the opposite effect.	6bh4	26-30	GTP cyclohydrolase I feedback regulator	Homo sapiens	158-162
16778797-2	2006	The rate-limiting step of 6BH4 de novo synthesis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulatory protein (GFRP), where binding of L-phenylalanine to GFRP increases enzyme activities, while 6BH4 exerts the opposite effect.	6bh4	26-30	GTP cyclohydrolase I feedback regulator	Homo sapiens	201-205
16778797-2	2006	The rate-limiting step of 6BH4 de novo synthesis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulatory protein (GFRP), where binding of L-phenylalanine to GFRP increases enzyme activities, while 6BH4 exerts the opposite effect.	6bh4	241-245	GTP cyclohydrolase 1	Homo sapiens	66-111
16778797-2	2006	The rate-limiting step of 6BH4 de novo synthesis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulatory protein (GFRP), where binding of L-phenylalanine to GFRP increases enzyme activities, while 6BH4 exerts the opposite effect.	6bh4	241-245	GTP cyclohydrolase I feedback regulator	Homo sapiens	158-162
16778797-2	2006	The rate-limiting step of 6BH4 de novo synthesis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulatory protein (GFRP), where binding of L-phenylalanine to GFRP increases enzyme activities, while 6BH4 exerts the opposite effect.	6bh4	241-245	GTP cyclohydrolase I feedback regulator	Homo sapiens	201-205
16778797-6	2006	Our results identified indeed a functioning GFRP/GTPCHI axis in epidermal keratinocytes and melanocytes in the cytosol, adding the missing link for 6BH4 de novo synthesis which in turn controls cofactor supply for catecholamine and serotonin biosynthesis as well as melanogenesis in the human epidermis.	6bh4	148-152	GTP cyclohydrolase I feedback regulator	Homo sapiens	44-48
15009710-4	2004	In this report we have elucidated the influence of H2O2 on dihydropteridine reductase (DHPR), the last enzyme in the 6BH4-recycling process.	6bh4	117-121	quinoid dihydropteridine reductase	Homo sapiens	59-85
15009710-4	2004	In this report we have elucidated the influence of H2O2 on dihydropteridine reductase (DHPR), the last enzyme in the 6BH4-recycling process.	6bh4	117-121	quinoid dihydropteridine reductase	Homo sapiens	87-91
24853563-5	2014	However, unlike IBMX and scoparone, but similar to alpha-MSH, P9 and P10 were able to reverse 6BH4-dependent tyrosinase inhibition.	6bh4	94-98	S100 calcium binding protein A10 (calpactin)	Mus musculus	69-72
17847704-1	2007	This study explains the action of compounds such as 6-tetrahydrobiopterin, (6BH4) and 6,7-dimethyltetrahydrobiopterin (6,7-di-CH3BH4) on the monophenolase and diphenolase activities of tyrosinase.	6bh4	76-80	tyrosinase	Homo sapiens	185-195
10643998-2	1999	In this context, it has been shown that the cofactor 6(R)-L-erythro 5,6,7,8 tetrahydrobiopterin (6BH4) is produced de novo, recycled and regulated in both epidermal melanocytes and keratinocytes to control tyrosine hydroxylase, phenylalanine hydroxylase and tyrosinase activity.	6bh4	97-101	phenylalanine hydroxylase	Homo sapiens	228-253
10643998-2	1999	In this context, it has been shown that the cofactor 6(R)-L-erythro 5,6,7,8 tetrahydrobiopterin (6BH4) is produced de novo, recycled and regulated in both epidermal melanocytes and keratinocytes to control tyrosine hydroxylase, phenylalanine hydroxylase and tyrosinase activity.	6bh4	97-101	tyrosinase	Homo sapiens	258-268
10643998-3	1999	Inhibition of the enzymes by excessive 6BH4 levels is reversible with alpha-MSH by specific complex formation between 6BH4 and the hormone.	6bh4	39-43	proopiomelanocortin	Homo sapiens	70-79
10643998-3	1999	Inhibition of the enzymes by excessive 6BH4 levels is reversible with alpha-MSH by specific complex formation between 6BH4 and the hormone.	6bh4	118-122	proopiomelanocortin	Homo sapiens	70-79
10816664-5	1999	Recently it was shown that tyrosinase activity is regulated by 6BH4 through a specific allosteric inhibition.	6bh4	63-67	tyrosinase	Homo sapiens	27-37
10816664-6	1999	The tyrosinase/6BH4 inhibition can be activated by 1:1 complex formation between 6BH4 and alpha-MSH, but an excess of alpha-MSH over 6BH4 can inhibit tyrosinase due to complex formation by tyr2 in the alpha-MSH sequence.	6bh4	15-19	tyrosinase	Homo sapiens	4-14
10816664-6	1999	The tyrosinase/6BH4 inhibition can be activated by 1:1 complex formation between 6BH4 and alpha-MSH, but an excess of alpha-MSH over 6BH4 can inhibit tyrosinase due to complex formation by tyr2 in the alpha-MSH sequence.	6bh4	15-19	proopiomelanocortin	Homo sapiens	90-99
10816664-6	1999	The tyrosinase/6BH4 inhibition can be activated by 1:1 complex formation between 6BH4 and alpha-MSH, but an excess of alpha-MSH over 6BH4 can inhibit tyrosinase due to complex formation by tyr2 in the alpha-MSH sequence.	6bh4	15-19	proopiomelanocortin	Homo sapiens	118-127
10816664-6	1999	The tyrosinase/6BH4 inhibition can be activated by 1:1 complex formation between 6BH4 and alpha-MSH, but an excess of alpha-MSH over 6BH4 can inhibit tyrosinase due to complex formation by tyr2 in the alpha-MSH sequence.	6bh4	15-19	proopiomelanocortin	Homo sapiens	118-127
10816664-6	1999	The tyrosinase/6BH4 inhibition can be activated by 1:1 complex formation between 6BH4 and alpha-MSH, but an excess of alpha-MSH over 6BH4 can inhibit tyrosinase due to complex formation by tyr2 in the alpha-MSH sequence.	6bh4	81-85	tyrosinase	Homo sapiens	4-14
10816664-6	1999	The tyrosinase/6BH4 inhibition can be activated by 1:1 complex formation between 6BH4 and alpha-MSH, but an excess of alpha-MSH over 6BH4 can inhibit tyrosinase due to complex formation by tyr2 in the alpha-MSH sequence.	6bh4	81-85	tyrosinase	Homo sapiens	4-14
10816664-7	1999	In both melanocytes and keratinocytes 6BH4 controls the L-tyrosine supply via phenylalanine hydroxylase (PAH).	6bh4	38-42	phenylalanine hydroxylase	Homo sapiens	78-103
10816664-9	1999	alpha-MSH can promote the production of L-tyrosine via PAH due to activation of the PAH tetramer to the more active dimer by removing 6BH4 from the regulatory binding domain on the enzyme.	6bh4	134-138	proopiomelanocortin	Homo sapiens	0-9