PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28628491-8	2017	Together, our findings show that calcein-AM, the cell-permeable derivative of calcein, exerts significant antitumor effects in NSCLC, and can enhance the antitumor effect of doxorubicin by regulating the TopBP1/mutp53 pathway.	fluorexon	33-40	DNA topoisomerase II binding protein 1	Homo sapiens	204-210
28707873-4	2017	Using amperometry to detect individual vesicle release events, we show that when calcein is present in the media, the number of vesicles that fuse with the cellular membrane is reduced when cells are stimulated with either nicotine or high K+.	fluorexon	81-88	Polykaryocytosis inducer	Homo sapiens	142-146
28655872-4	2017	We monitored mPTP opening using the calcein/cobalt fluorescence technique in adult rat and wild type or cyclophilin D (CypD) knock-out mice cardiomyocytes.	fluorexon	36-43	protein tyrosine phosphatase, receptor type, U	Mus musculus	13-17
27951701-5	2016	The UTMs represented selective adsorption behaviors toward hydrophilic dyes even with similar backbones and the same charge states, namely, they showed high adsorption capacities (Qeq) toward eosin B, erythrosin B (ETB), 4",5"-dibromofluorescein, and Evans blue (EVB) dyes up to 300 mumol/g while showing low adsorption capacities toward calcein (Cal), methyl red, and Ponceau S dyes.	fluorexon	338-345	endothelin receptor type B	Homo sapiens	215-218
27865984-3	2017	DPPC/P188 liposomes released approximately 80% of the encapsulated calcein (a fluorescence marker) within 10min in the presence of 120 mU of PLA2 at 37 C in vitro, whereas several other liposomal compositions used for inhalation therapy did not.	fluorexon	67-74	phospholipase A2 group IB	Homo sapiens	141-145
28258008-9	2017	Inhibition of MRP1 activity was further validated using flow cytometry and confocal microscopy for the respective detection of calcein and doxorubicin in MRP1-overexpressing cells.	fluorexon	127-134	ATP binding cassette subfamily C member 1	Homo sapiens	14-18
28258008-9	2017	Inhibition of MRP1 activity was further validated using flow cytometry and confocal microscopy for the respective detection of calcein and doxorubicin in MRP1-overexpressing cells.	fluorexon	127-134	ATP binding cassette subfamily C member 1	Homo sapiens	154-158
29441989-8	2017	ARF rat plasma (5%) significantly increased the accumulation of calcein, a MRP substrate, in HepG2 cells after application of calcein-AM.	fluorexon	64-71	ATP binding cassette subfamily C member 2	Rattus norvegicus	75-78
27951701-5	2016	The UTMs represented selective adsorption behaviors toward hydrophilic dyes even with similar backbones and the same charge states, namely, they showed high adsorption capacities (Qeq) toward eosin B, erythrosin B (ETB), 4",5"-dibromofluorescein, and Evans blue (EVB) dyes up to 300 mumol/g while showing low adsorption capacities toward calcein (Cal), methyl red, and Ponceau S dyes.	fluorexon	347-350	endothelin receptor type B	Homo sapiens	215-218
26685080-4	2016	We developed a high-throughput assay to screen a library of compounds as potential AQP1 modulators by monitoring the fluorescence dequenching of entrapped calcein in a confluent layer of AQP1-overexpressing CHO cells that were exposed to a hypotonic shock.	fluorexon	155-162	aquaporin-1	Cricetulus griseus	83-87
27373212-5	2016	Knockdown of MCT1 or/and PFKFB3 increased the apoptosis rate of the HUVECs under single-culture and co-culture situations by staining with calcein and propidium iodide.	fluorexon	139-146	solute carrier family 16 member 1	Homo sapiens	13-17
27373212-5	2016	Knockdown of MCT1 or/and PFKFB3 increased the apoptosis rate of the HUVECs under single-culture and co-culture situations by staining with calcein and propidium iodide.	fluorexon	139-146	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	25-31
26685080-4	2016	We developed a high-throughput assay to screen a library of compounds as potential AQP1 modulators by monitoring the fluorescence dequenching of entrapped calcein in a confluent layer of AQP1-overexpressing CHO cells that were exposed to a hypotonic shock.	fluorexon	155-162	aquaporin-1	Cricetulus griseus	187-191
25538692-9	2014	With fluorescein isothiocyanate (FITC), 20-25 mg/L K20 caused staining of >95% of C. neoformans and Fusarium graminearum cells and at 31.3 mg/L caused rapid leakage (30-80% in 15 min) of calcein from preloaded small unilamellar lipid vesicles.	fluorexon	190-197	keratin 20	Homo sapiens	51-54
26208637-6	2015	By selectively loading the iron-chelating fluorochrome calcein in macropinosomes, we show that Dictyostelium Nramp1 mediates iron efflux from macropinosomes in vivo.	fluorexon	55-62	solute carrier family 11 member 1	Homo sapiens	109-115
25590378-14	2015	P-gp activity was confirmed by calcein accumulation (mean 38.6%; 95% CI:32.8-44.4%), which was higher in cell lines with the ABCB1 3435TT than the 3435CC/CT genotype (46.2% vs 35.5%; 95% CI:28.7-42.2%).	fluorexon	31-38	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
25590378-14	2015	P-gp activity was confirmed by calcein accumulation (mean 38.6%; 95% CI:32.8-44.4%), which was higher in cell lines with the ABCB1 3435TT than the 3435CC/CT genotype (46.2% vs 35.5%; 95% CI:28.7-42.2%).	fluorexon	31-38	ATP binding cassette subfamily B member 1	Homo sapiens	125-130
26208637-8	2015	Using a novel assay with calcein, and electrophysiological and radiochemical assays, we show that Nramp1, similar to rat DMT1 (also known as SLC11A2), transports Fe(2+) and manganese, not Fe(3+) or copper.	fluorexon	25-32	solute carrier family 11 member 1	Rattus norvegicus	98-104
23742857-4	2013	The activities of P-gp and MRP2 were determined by following the intracellular accumulation of calcein and 5(6)-carboxy-2",7"-dichlorofluorescein in the uptake assays with fluorescence spectroscopy.	fluorexon	95-102	ATP binding cassette subfamily B member 1	Homo sapiens	18-22
25400145-5	2014	Calcein AM, the cell-permeable derivative of calcein, shows significant antitumour activity in a wide spectrum of cultured cancer cells harbouring high TopBP1 levels.	fluorexon	45-52	DNA topoisomerase II binding protein 1	Homo sapiens	152-158
25260713-5	2014	siRNA for Cav3.2 reduced EGCG cytotoxicity to MCF-7 cells, as measured by calcein viability assay.	fluorexon	74-81	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	10-16
24690257-6	2014	ABCB1 transporter (PGP1) inhibition was assessed using the acetomethoxy derivate of calcein (calcein-AM) as a fluorescent probe in both wild-type MDCKII and PGP1 overexpressing MDCKII cells.	fluorexon	84-91	ATP binding cassette subfamily B member 1	Canis lupus familiaris	0-5
24690257-6	2014	ABCB1 transporter (PGP1) inhibition was assessed using the acetomethoxy derivate of calcein (calcein-AM) as a fluorescent probe in both wild-type MDCKII and PGP1 overexpressing MDCKII cells.	fluorexon	84-91	CD44 molecule	Canis lupus familiaris	19-23
24595806-5	2014	In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions.	fluorexon	84-91	ATP binding cassette subfamily B member 1	Homo sapiens	24-28
24595806-5	2014	In folate-deprived 2008/MRP1 cells, the MRP1-mediated efflux of its model substrate calcein decreased to ~55 % of the initial efflux rate under folate-rich conditions.	fluorexon	84-91	ATP binding cassette subfamily B member 1	Homo sapiens	40-44
24595806-7	2014	Folate depletion for 5-10 days markedly increased (~500 %) cellular steady-state accumulation of calcein in 2008/MRP1 cells and moderately in 2008wt cells.	fluorexon	97-104	ATP binding cassette subfamily B member 1	Homo sapiens	113-117
24595806-8	2014	A subsequent short (24 h) exposure to 2.3 muM L-leucovorin decreased calcein levels again in MRP1-overexpressing cells.	fluorexon	69-76	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
24641346-3	2014	When incubated with calcein-AM, a substrate of the efflux transporter P-glycoprotein (Pgp), spheroids from a variety of cell types accumulated calcein over time.	fluorexon	20-27	ATP binding cassette subfamily B member 1	Homo sapiens	70-84
24641346-3	2014	When incubated with calcein-AM, a substrate of the efflux transporter P-glycoprotein (Pgp), spheroids from a variety of cell types accumulated calcein over time.	fluorexon	20-27	ATP binding cassette subfamily B member 1	Homo sapiens	86-89
24328262-3	2014	The PRX core-shell particles are able to sequester small organic molecules, such as pyrene and calcein, releasing these small molecules during degradation.	fluorexon	95-102	periaxin	Homo sapiens	4-7
24058883-13	2013	P-gp dependent efflux (of calcein, DiOC2(3) and rh123) was inhibited upon short-term exposure to CBD.	fluorexon	26-33	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
23742857-4	2013	The activities of P-gp and MRP2 were determined by following the intracellular accumulation of calcein and 5(6)-carboxy-2",7"-dichlorofluorescein in the uptake assays with fluorescence spectroscopy.	fluorexon	95-102	ATP binding cassette subfamily C member 2	Homo sapiens	27-31
23445664-2	2013	Here, we combined dual patch clamp and fluorescence imaging techniques with molecular dynamics (MD) simulations to investigate the permeation of calcein, a relatively large fluorescent tracer (MW 622 Da) through homomeric gap junction channels formed by wild type human connexin26 (hCx26wt) protomers.	fluorexon	145-152	gap junction protein beta 2	Homo sapiens	270-280
23341575-8	2013	Finally, FGF-2 stimulated efflux transport of calcein and DOX, and treatment with efflux transporter inhibitors significantly attenuated the protective effect of FGF-2 from DOX-induced injury.	fluorexon	46-53	fibroblast growth factor 2	Rattus norvegicus	9-14
23341575-8	2013	Finally, FGF-2 stimulated efflux transport of calcein and DOX, and treatment with efflux transporter inhibitors significantly attenuated the protective effect of FGF-2 from DOX-induced injury.	fluorexon	46-53	fibroblast growth factor 2	Rattus norvegicus	162-167
22469515-8	2012	Accordingly, efflux and MTT assays showed that the radixin knockdown cells exhibited lower efflux ability with respect to calcein but no significant change in cell viability.	fluorexon	122-129	radixin	Homo sapiens	51-58
23468473-0	2013	Calcein-effluxing human colon cancer cells are enriched for self-renewal capacity and depend on beta-catenin.	fluorexon	0-7	catenin beta 1	Homo sapiens	96-108
23012425-6	2012	Finally, we utilized sonoporation to deliver calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (MRP1), into HEK-MRP1 cells, which overexpress MRP1, and monitored the calcein efflux by MRP1.	fluorexon	45-52	ATP binding cassette subfamily B member 1	Homo sapiens	89-119
23012425-6	2012	Finally, we utilized sonoporation to deliver calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (MRP1), into HEK-MRP1 cells, which overexpress MRP1, and monitored the calcein efflux by MRP1.	fluorexon	45-52	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
23012425-6	2012	Finally, we utilized sonoporation to deliver calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (MRP1), into HEK-MRP1 cells, which overexpress MRP1, and monitored the calcein efflux by MRP1.	fluorexon	45-52	ATP binding cassette subfamily B member 1	Homo sapiens	137-141
23012425-6	2012	Finally, we utilized sonoporation to deliver calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (MRP1), into HEK-MRP1 cells, which overexpress MRP1, and monitored the calcein efflux by MRP1.	fluorexon	45-52	ATP binding cassette subfamily B member 1	Homo sapiens	137-141
23012425-6	2012	Finally, we utilized sonoporation to deliver calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (MRP1), into HEK-MRP1 cells, which overexpress MRP1, and monitored the calcein efflux by MRP1.	fluorexon	45-52	ATP binding cassette subfamily B member 1	Homo sapiens	137-141
22649071-4	2012	Since little is known about the GJC dynamic regulation between cumulus cells, we have developed an assay based on recovery of calcein fluorescence in photobleached cumulus cells, a gap-FRAP assay.	fluorexon	126-133	mechanistic target of rapamycin kinase	Homo sapiens	185-189
22445357-9	2012	We also found that CD40-stimulated, MRP1-expressing KMS28BM cells significantly increased calcein efflux, and calcein efflux was inhibited through treatment with MK-571.	fluorexon	90-97	CD40 molecule	Homo sapiens	19-23
22445357-9	2012	We also found that CD40-stimulated, MRP1-expressing KMS28BM cells significantly increased calcein efflux, and calcein efflux was inhibited through treatment with MK-571.	fluorexon	90-97	ATP binding cassette subfamily C member 1	Homo sapiens	36-40
22770743-3	2012	The activity of ABC transporter was determined in resistant and sensitive cells by spectrofluorometry and flow cytometry using the substrates doxorubicin, rhodamine 123, and calcein as fluorescent probes.	fluorexon	174-181	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	16-31
22621404-6	2012	When calcein is replaced by bleomycin, the liposomes effectively reduce viability of five different Her-2 overexpressing cell lines (BT-474, SKBR-3, MCF-7/Her18, HCC-1954 and MDA-453) while harming to a much lesser extent Her-2 negative breast cell lines (MCF-7, MCF-12a and MCF-10a).	fluorexon	5-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-105
22621404-6	2012	When calcein is replaced by bleomycin, the liposomes effectively reduce viability of five different Her-2 overexpressing cell lines (BT-474, SKBR-3, MCF-7/Her18, HCC-1954 and MDA-453) while harming to a much lesser extent Her-2 negative breast cell lines (MCF-7, MCF-12a and MCF-10a).	fluorexon	5-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	222-227
22445357-9	2012	We also found that CD40-stimulated, MRP1-expressing KMS28BM cells significantly increased calcein efflux, and calcein efflux was inhibited through treatment with MK-571.	fluorexon	110-117	CD40 molecule	Homo sapiens	19-23
21959501-5	2011	However, when reperfusion was performed after 25 min simulated ischemia, CyD ablation improved DeltaPsim recovery and reduced calcein release and cell death (57.8 +- 4.9% vs. 77.3 +- 4.8%, P < 0.01).	fluorexon	126-133	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	73-76
22445357-9	2012	We also found that CD40-stimulated, MRP1-expressing KMS28BM cells significantly increased calcein efflux, and calcein efflux was inhibited through treatment with MK-571.	fluorexon	110-117	ATP binding cassette subfamily C member 1	Homo sapiens	36-40
22027652-8	2011	RESULTS: At a comparable expression level, the ABCC2 4544A clone showed higher accumulation of LPV, calcein and carboxyfluorescein diacetate as well as reduced ABCC2-mediated efflux of LPV compared with the ABCC2 4544G clone.	fluorexon	100-107	ATP binding cassette subfamily C member 2	Homo sapiens	47-52
21605668-0	2011	Characterization of rhodamine-123, calcein and 5(6)-carboxy-2",7"-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells.	fluorexon	35-42	ATP binding cassette subfamily C member 2	Homo sapiens	104-108
21605668-0	2011	Characterization of rhodamine-123, calcein and 5(6)-carboxy-2",7"-dichlorofluorescein (CDCF) export via MRP2 (ABCC2) in MES-SA and A549 cells.	fluorexon	35-42	ATP binding cassette subfamily C member 2	Homo sapiens	110-115
21501640-5	2011	HER2(+)affisomes were either (i) fluorescently labeled with rhodamine-PE and calcein or (ii) loaded with an anticancer drug doxorubicin (DOX).	fluorexon	77-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
19059376-3	2009	We demonstrated DMRP as a functional orthologue of its human counterparts capable of transporting several human MRP substrates like beta-estradiol 17-beta-D-glucuronide, leukotriene C4, calcein, fluo3 and carboxydichlorofluorescein.	fluorexon	186-193	Multidrug-Resistance like Protein 1	Drosophila melanogaster	17-20
20819947-2	2010	Interdependence among water, Na+ and Cl(-) fluxes mediated by NKCC1 was inferred from changes in cell water volume, monitored by intracellular self-quenching of the fluorescent dye calcein.	fluorexon	181-188	solute carrier family 12 member 2	Homo sapiens	62-67
21657832-8	2011	The Calcein assay is a high-throughput alternative to digoxin transport inhibition as it appears to have a comparable selectivity but higher sensitivity than previously published digoxin transport inhibition in MDCKII-MDR1 cells.	fluorexon	4-11	ATP binding cassette subfamily B member 1	Homo sapiens	211-222
20096356-6	2010	Furthermore, 8/9 Cx26 mutants inhibited the transfer of neurobiotin or calcein, indicating that these Cx26 mutants have trans-dominant effects on Cx30, an effect that may contribute to the pathogenesis of hearing loss.	fluorexon	71-78	gap junction protein beta 2	Homo sapiens	17-21
20096356-6	2010	Furthermore, 8/9 Cx26 mutants inhibited the transfer of neurobiotin or calcein, indicating that these Cx26 mutants have trans-dominant effects on Cx30, an effect that may contribute to the pathogenesis of hearing loss.	fluorexon	71-78	gap junction protein beta 2	Homo sapiens	102-106
20096356-6	2010	Furthermore, 8/9 Cx26 mutants inhibited the transfer of neurobiotin or calcein, indicating that these Cx26 mutants have trans-dominant effects on Cx30, an effect that may contribute to the pathogenesis of hearing loss.	fluorexon	71-78	gap junction protein beta 6	Homo sapiens	146-150
20017192-3	2010	Here we report that, compared to EC incubated in medium, IL-4-treated EC had a profound reduction in complement-mediated ATP loss and in killing assessed by vital dye uptake, but only a slight reduction in permeability disruption measured by calcein release.	fluorexon	242-249	interleukin 4	Homo sapiens	57-61
18204840-5	2008	Glycyrrhetinic acid and matairesinol also increased the accumulation of calcein, a fluorescent substrate of MRP1, in KB/MRP cells.	fluorexon	72-79	ATP binding cassette subfamily B member 1	Homo sapiens	108-112
19073204-2	2009	In contrast to a marginal activity noted with beta-Bgt, recombinant A1 chain and B1 chain markedly induced release of calcein from phospholipid vesicles.	fluorexon	118-125	membrane spanning 4-domains A1	Homo sapiens	68-83
18539442-3	2008	To better understand these relationships, the influence of membrane cholesterol content on Pgp function, as measured via calcein accumulation, was studied in correlation with changes elicited in membrane structure.	fluorexon	121-128	ATP binding cassette subfamily B member 1	Homo sapiens	91-94
17328866-7	2007	In the calcein assay, all PIs, all NNRTIs, abacavir, and tenofovir disoproxil fumarate acted as P-gp inhibitors with largely differing potencies between compounds.	fluorexon	7-14	phosphoglycolate phosphatase	Mus musculus	96-100
18280247-5	2008	Guggulsterone also increased the accumulation of calcein, a fluorescent substrate of MRP1, in KB/MRP cells.	fluorexon	49-56	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
15987604-6	2005	Calcein transfer assay showed that calcein transfer was inhibited when cells were treated with Brefeldin A or cytochalasin D, but not when treated with nocodazole or a-glycyrrhetinic acid, suggesting that Golgi apparatus and actin filaments, but not microtubules, are crucial to the trafficking and assembly of connexin 31, as well as the formation of gap junction intercellular communication by connexin 31.	fluorexon	0-7	gap junction protein beta 3	Homo sapiens	311-322
16960658-15	2007	Similarly with MRP1, the efflux of a fluorescent substrate calcein AM was inhibited effectively by THC thereby the accumulation of calcein was increased in MRP1-HEK 293 and not its parental pcDNA3.1-HEK 293 cells.	fluorexon	59-66	ATP binding cassette subfamily C member 1	Homo sapiens	15-19
16960658-15	2007	Similarly with MRP1, the efflux of a fluorescent substrate calcein AM was inhibited effectively by THC thereby the accumulation of calcein was increased in MRP1-HEK 293 and not its parental pcDNA3.1-HEK 293 cells.	fluorexon	59-66	ATP binding cassette subfamily C member 1	Homo sapiens	156-160
16004972-5	2005	They also inhibited transport in membrane vesicles prepared from tumour cells expressing MRP1 or MRP4 and blocked calcein efflux from MRP1-overexpressing cells and BCECF efflux from MRP4-overexpressing cells.	fluorexon	114-121	ATP binding cassette subfamily C member 1	Homo sapiens	89-93
16004972-5	2005	They also inhibited transport in membrane vesicles prepared from tumour cells expressing MRP1 or MRP4 and blocked calcein efflux from MRP1-overexpressing cells and BCECF efflux from MRP4-overexpressing cells.	fluorexon	114-121	ATP binding cassette subfamily C member 4	Homo sapiens	97-101
16004972-5	2005	They also inhibited transport in membrane vesicles prepared from tumour cells expressing MRP1 or MRP4 and blocked calcein efflux from MRP1-overexpressing cells and BCECF efflux from MRP4-overexpressing cells.	fluorexon	114-121	ATP binding cassette subfamily C member 1	Homo sapiens	134-138
16602625-6	2005	MRP2 induction by staurosporine and H-7 was shown to have phenotypic consequences in whole cells, rendering them more resistant to etoposide and increasing their ability to export calcein through the plasma membrane.	fluorexon	180-187	ATP binding cassette subfamily C member 2	Homo sapiens	0-4
17088052-6	2007	Pgp and Mrp transport activity were analyzed by measuring calcein accumulation and glutathione-S-bimane efflux, respectively.	fluorexon	58-65	ATP binding cassette subfamily C member 2	Rattus norvegicus	8-11
16130718-2	2005	Phospholipase A2 (PLA2)-catalyzed membrane leakage can be detected by immobilized liposomes containing a self-quenching fluorescent dye, 3,3-bis[N,N-di(carboxymethyl)aminomethyl]fluorescein (calcein).	fluorexon	191-198	phospholipase A2 group IB	Homo sapiens	0-16
16130718-2	2005	Phospholipase A2 (PLA2)-catalyzed membrane leakage can be detected by immobilized liposomes containing a self-quenching fluorescent dye, 3,3-bis[N,N-di(carboxymethyl)aminomethyl]fluorescein (calcein).	fluorexon	191-198	phospholipase A2 group IB	Homo sapiens	18-22
15987604-6	2005	Calcein transfer assay showed that calcein transfer was inhibited when cells were treated with Brefeldin A or cytochalasin D, but not when treated with nocodazole or a-glycyrrhetinic acid, suggesting that Golgi apparatus and actin filaments, but not microtubules, are crucial to the trafficking and assembly of connexin 31, as well as the formation of gap junction intercellular communication by connexin 31.	fluorexon	0-7	gap junction protein beta 3	Homo sapiens	396-407
14998587-6	2004	This idea was supported in the calcein AM Pgp transport assay in which two of the tested local anaesthetic agents affected cellular calcein retention.	fluorexon	31-38	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	42-45
15670588-2	2005	The results were used to define the structural requirements of flavonoids necessary for potent inhibition of MRP1- and MRP2-mediated calcein transport in a cellular model.	fluorexon	133-140	ATP binding cassette subfamily C member 1	Canis lupus familiaris	109-113
15670588-2	2005	The results were used to define the structural requirements of flavonoids necessary for potent inhibition of MRP1- and MRP2-mediated calcein transport in a cellular model.	fluorexon	133-140	ATP binding cassette subfamily C member 2	Canis lupus familiaris	119-123
15670588-6	2005	For one flavonoid, robinetin, the kinetics of inhibition were studied in more detail and revealed competitive inhibition with respect to calcein, with apparent inhibition constants of 5.0 microM for MRP1 and 8.5 microM for MRP2.	fluorexon	137-144	ATP binding cassette subfamily C member 1	Canis lupus familiaris	199-203
15670588-6	2005	For one flavonoid, robinetin, the kinetics of inhibition were studied in more detail and revealed competitive inhibition with respect to calcein, with apparent inhibition constants of 5.0 microM for MRP1 and 8.5 microM for MRP2.	fluorexon	137-144	ATP binding cassette subfamily C member 2	Canis lupus familiaris	223-227
15198509-3	2004	As preclinical drug disposition and pharmacokinetics studies are often conducted in rats, we have recently cloned the rat MRP1 (rMRP1) and demonstrated that rMRP1 expressed in transfected cells effluxes calcein, a commonly used fluorescence substrate for human MRP1.	fluorexon	203-210	ATP binding cassette subfamily C member 1	Rattus norvegicus	122-126
15198509-3	2004	As preclinical drug disposition and pharmacokinetics studies are often conducted in rats, we have recently cloned the rat MRP1 (rMRP1) and demonstrated that rMRP1 expressed in transfected cells effluxes calcein, a commonly used fluorescence substrate for human MRP1.	fluorexon	203-210	ATP binding cassette subfamily C member 1	Rattus norvegicus	128-133
15198509-3	2004	As preclinical drug disposition and pharmacokinetics studies are often conducted in rats, we have recently cloned the rat MRP1 (rMRP1) and demonstrated that rMRP1 expressed in transfected cells effluxes calcein, a commonly used fluorescence substrate for human MRP1.	fluorexon	203-210	ATP binding cassette subfamily C member 1	Rattus norvegicus	157-162
15198509-3	2004	As preclinical drug disposition and pharmacokinetics studies are often conducted in rats, we have recently cloned the rat MRP1 (rMRP1) and demonstrated that rMRP1 expressed in transfected cells effluxes calcein, a commonly used fluorescence substrate for human MRP1.	fluorexon	203-210	ATP binding cassette subfamily C member 1	Homo sapiens	129-133
14998587-6	2004	This idea was supported in the calcein AM Pgp transport assay in which two of the tested local anaesthetic agents affected cellular calcein retention.	fluorexon	132-139	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	42-45
14569083-7	2003	Membrane vesicles from Sf9 cells expressing human MRP2 or human MRP4 indicated that MRP2 exhibits a preferential affinity for calcein and fluo-3, whereas LY is a better substrate for MRP4.	fluorexon	126-133	ATP binding cassette subfamily C member 4	Homo sapiens	64-68
14569083-7	2003	Membrane vesicles from Sf9 cells expressing human MRP2 or human MRP4 indicated that MRP2 exhibits a preferential affinity for calcein and fluo-3, whereas LY is a better substrate for MRP4.	fluorexon	126-133	ATP binding cassette subfamily C member 2	Homo sapiens	50-54
14569083-7	2003	Membrane vesicles from Sf9 cells expressing human MRP2 or human MRP4 indicated that MRP2 exhibits a preferential affinity for calcein and fluo-3, whereas LY is a better substrate for MRP4.	fluorexon	126-133	ATP binding cassette subfamily C member 2	Homo sapiens	84-88
12879156-1	2003	We employed human red blood cells as a model system to check the affinity of MRP1 (Multidrug Resistance-associated Protein 1) towards fluorescein and a set of its carboxyl derivatives: 5/6-carboxyfluorescein (CF), 2",7"-bis-(2-carboxyethyl)-5/6-carboxyfluorescein (BCECF) and calcein (CAL).	fluorexon	276-283	ATP binding cassette subfamily C member 1	Homo sapiens	77-81
12879156-1	2003	We employed human red blood cells as a model system to check the affinity of MRP1 (Multidrug Resistance-associated Protein 1) towards fluorescein and a set of its carboxyl derivatives: 5/6-carboxyfluorescein (CF), 2",7"-bis-(2-carboxyethyl)-5/6-carboxyfluorescein (BCECF) and calcein (CAL).	fluorexon	276-283	ATP binding cassette subfamily C member 1	Homo sapiens	83-124
12200437-5	2002	As these enzymes release their iron ions under oxidative-stress conditions, the intracellular labile iron pool, monitored with calcein, was higher in cells with reduced Hsp60 levels.	fluorexon	127-134	chaperone ATPase HSP60	Saccharomyces cerevisiae S288C	169-174
12975603-6	2002	Double tetracycline-calcein labeling revealed that the biglycan deficient mice are defective in their capacity to form bone.	fluorexon	20-27	biglycan	Mus musculus	55-63
10917553-8	2000	Unexpectedly, export of the organic anion calcein by MDCKII-MRP1 and MDCKII-MRP2 cells is stimulated by Pluronic L61, probably because it relieves the block on entry of calcein AM into the cell by endogenous MDR1 Pgp.	fluorexon	42-49	ATP binding cassette subfamily C member 1	Canis lupus familiaris	60-64
11389878-8	2001	Agents shown to reduce efflux of calcein from resistant cells, i.e. indomethacin, MK-571, and probenecid, also inhibited [(3)H]DNP-SG uptakes, consistent with MRP1 being responsible for export of calcein.	fluorexon	33-40	ATP binding cassette subfamily C member 1	Homo sapiens	159-163
11205902-3	2001	Flavopiridol at a concentration of 10 microM was able to prevent MRP-mediated calcein efflux, whereas Pgp-mediated transport of rhodamine 123 was unaffected at flavopiridol concentrations of up to 100 microM.	fluorexon	78-85	ATP binding cassette subfamily C member 3	Homo sapiens	65-68
11961113-8	2002	A final pharmacophore was generated for inhibition of calcein accumulation in P-gp expressing LLC-PK1 cells and found to contain two hydrophobes, a ring aromatic feature, and a hydrogen bond donor.	fluorexon	54-61	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
11737211-5	2001	In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells.	fluorexon	235-242	ATP binding cassette subfamily C member 1	Homo sapiens	25-29
11737211-5	2001	In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells.	fluorexon	235-242	ATP binding cassette subfamily C member 1	Homo sapiens	55-59
11737211-5	2001	In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells.	fluorexon	235-242	ATP binding cassette subfamily C member 1	Homo sapiens	55-59
11737211-5	2001	In both erythrocytes and MRP1-expressing tumour cells, MRP1-associated transport is inhibited by clotrimazole over the range 2-20 microm, and the inhibitory effect leads to increases in accumulation of MRP1 substrates, vincristine and calcein, and decreases in calcein efflux from intact MRP1-expressing human tumour cells.	fluorexon	235-242	ATP binding cassette subfamily C member 1	Homo sapiens	55-59
11504821-5	2001	Total calcein efflux was significantly decreased with the MRP1 inhibitors probenecid and indomethacin, while total efflux was unchanged following treatment with CsA.	fluorexon	6-13	ATP binding cassette subfamily C member 1	Homo sapiens	58-62
11245485-9	2001	We have developed a microvideo assay based on the properties of acetoxymethyl ester calcein and calcein to show that this P-gp extruded the hydrophobic acetoxymethyl ester calcein.	fluorexon	84-91	ATP binding cassette subfamily B member 1	Homo sapiens	122-126
11159731-5	2001	Intracellular accumulation of calcein, an anionic dye substrate for MRP1, was strongly increased by glibenclamide in a dose-dependent manner in MRP1-overexpressing lung tumour GLC4/Sb30 cells through inhibition of MRP1-related calcein efflux.	fluorexon	30-37	ATP binding cassette subfamily B member 1	Homo sapiens	68-72
11159731-5	2001	Intracellular accumulation of calcein, an anionic dye substrate for MRP1, was strongly increased by glibenclamide in a dose-dependent manner in MRP1-overexpressing lung tumour GLC4/Sb30 cells through inhibition of MRP1-related calcein efflux.	fluorexon	30-37	ATP binding cassette subfamily B member 1	Homo sapiens	144-148
11159731-5	2001	Intracellular accumulation of calcein, an anionic dye substrate for MRP1, was strongly increased by glibenclamide in a dose-dependent manner in MRP1-overexpressing lung tumour GLC4/Sb30 cells through inhibition of MRP1-related calcein efflux.	fluorexon	30-37	ATP binding cassette subfamily B member 1	Homo sapiens	144-148
10917553-8	2000	Unexpectedly, export of the organic anion calcein by MDCKII-MRP1 and MDCKII-MRP2 cells is stimulated by Pluronic L61, probably because it relieves the block on entry of calcein AM into the cell by endogenous MDR1 Pgp.	fluorexon	42-49	ATP binding cassette subfamily C member 2	Canis lupus familiaris	76-80
10917553-8	2000	Unexpectedly, export of the organic anion calcein by MDCKII-MRP1 and MDCKII-MRP2 cells is stimulated by Pluronic L61, probably because it relieves the block on entry of calcein AM into the cell by endogenous MDR1 Pgp.	fluorexon	42-49	ATP binding cassette subfamily B member 1	Canis lupus familiaris	208-212
10917553-8	2000	Unexpectedly, export of the organic anion calcein by MDCKII-MRP1 and MDCKII-MRP2 cells is stimulated by Pluronic L61, probably because it relieves the block on entry of calcein AM into the cell by endogenous MDR1 Pgp.	fluorexon	42-49	PGP	Canis lupus familiaris	213-216
10764626-3	2000	Intracellular accumulation of BaP or calcein, a substrate for P-gp and multidrug resistance protein (MRP), was not altered by inhibitors of the P-gp and MRP.	fluorexon	37-44	ATP binding cassette subfamily B member 1	Homo sapiens	62-66
10764626-3	2000	Intracellular accumulation of BaP or calcein, a substrate for P-gp and multidrug resistance protein (MRP), was not altered by inhibitors of the P-gp and MRP.	fluorexon	37-44	ATP binding cassette subfamily C member 1	Homo sapiens	71-99
10764626-3	2000	Intracellular accumulation of BaP or calcein, a substrate for P-gp and multidrug resistance protein (MRP), was not altered by inhibitors of the P-gp and MRP.	fluorexon	37-44	ATP binding cassette subfamily C member 1	Homo sapiens	101-104
10729360-11	2000	PAK-104P also non-competitively inhibits the MRP(1)-mediated efflux of daunorubicin, pirarubicin, hydroxyrubicin, calcein acetoxymethyl ester and calcein.	fluorexon	114-121	ATP binding cassette subfamily C member 1	Homo sapiens	45-50
10729360-13	2000	These data strongly suggested the existence of two different mechanisms for the inhibition by PAK-104P of the MRP(1)-mediated efflux of molecules: a first mechanism, involving a low-affinity site for PAK-104P, and which would concern molecules such as calcein, cysteinyl leukotriene LCT(4) etc.	fluorexon	252-259	ATP binding cassette subfamily C member 1	Homo sapiens	110-115
10531385-6	1999	At a concentration of 125 nM, Bax caused the release of the intermembranous proteins cytochrome c and adenylate kinase and the release from the matrix of sequestered calcein, effects prevented by the inhibitor of the PTP cyclosporin A (CSA).	fluorexon	166-173	BCL2 associated X, apoptosis regulator	Homo sapiens	30-33
9804615-9	1998	Using a fluorescence activated cell sorter assay to measure competition of calcein efflux from MRP-overexpressing cells, 10 compounds were found to increase calcein retention by >/=2-fold.	fluorexon	75-82	ATP binding cassette subfamily C member 1	Homo sapiens	95-98
10404077-9	1999	Probenecid, an inhibitor of the MRP pump, significantly increased the accumulation of calcein in PBMC from 3 chronic ATL patients.	fluorexon	86-93	ATP binding cassette subfamily C member 1	Homo sapiens	32-35
10329417-3	1999	In such cells, the antihormone compound was found to increase intracellular accumulation of calcein, a fluorescent compound transported by MRP, in a dose-dependent manner, through inhibition of cellular export of the dye; in contrast, it did not alter calcein levels in parental GLC4 cells.	fluorexon	92-99	ATP binding cassette subfamily C member 3	Homo sapiens	139-142
10209965-6	1999	Analysis of MRP-related transport using 3 types of MRP substrates, namely, the fluorescent glutathione-bimane, the anionic dye calcein and the cationic anti-cancer drug vincristine, demonstrated that HTC cells displayed cellular efflux of these 3 compounds, an efflux strongly inhibited by MRP modulators such as indomethacin.	fluorexon	127-134	ATP binding cassette subfamily C member 2	Rattus norvegicus	12-15
10025956-4	1999	Indeed, GLC4/Sb30 cells were found to display a functional overexpression of the multidrug resistance-associated protein MRP1, a drug export pump, as demonstrated by Western blotting, reverse transcriptase-polymerase chain reaction and calcein accumulation assays.	fluorexon	236-243	ATP binding cassette subfamily C member 1	Homo sapiens	121-125
10438534-14	1999	Overexpression of pABC11 resulted in reduced labeling with the fluorochromes 5-chloromethylfluorescein diacetate, fluorescein diacetate, and 2",7"-bis-(2-carboxyethyl)-5 (and-6)-carboxyfluorescein acetoxymethyl ester but not with calcein or rhodamine derivatives, consistent with pABC11 being an anion transporter.	fluorexon	230-237	ATP binding cassette subfamily C member 5	Homo sapiens	18-24
9804615-9	1998	Using a fluorescence activated cell sorter assay to measure competition of calcein efflux from MRP-overexpressing cells, 10 compounds were found to increase calcein retention by >/=2-fold.	fluorexon	157-164	ATP binding cassette subfamily C member 1	Homo sapiens	95-98
9767529-7	1998	Immunocytochemistry revealed increased P-gp expression in the plasma membrane of HAEC and RPTC treated with 0.8 microM CsA, which was reflected by a decrease of P-gp-mediated accumulation of calcein in both cell types.	fluorexon	191-198	ATP binding cassette subfamily B member 1	Homo sapiens	39-43
9767529-7	1998	Immunocytochemistry revealed increased P-gp expression in the plasma membrane of HAEC and RPTC treated with 0.8 microM CsA, which was reflected by a decrease of P-gp-mediated accumulation of calcein in both cell types.	fluorexon	191-198	ATP binding cassette subfamily B member 1	Homo sapiens	161-165
9485370-3	1998	To obtain more insight in the handling of drugs by both proteins, we performed a detailed kinetic analysis of the efflux of calcein-acetoxymethyl ester (CAL-AM), a common neutral substrate for both proteins and compared it with the kinetics of efflux of calcein (CAL) which is only effluxed by MRP.	fluorexon	124-131	ATP binding cassette subfamily C member 1	Homo sapiens	294-297
9713496-4	1998	In the present work single-cell fluorescence digital imaging has been applied to characterize the kinetics and inhibitor-sensitivity of calcein accumulation in a mixture of HL60 MRP1 and NIH 3T3 MDR1 cells.	fluorexon	136-143	ATP binding cassette subfamily C member 1	Homo sapiens	178-182
9713496-4	1998	In the present work single-cell fluorescence digital imaging has been applied to characterize the kinetics and inhibitor-sensitivity of calcein accumulation in a mixture of HL60 MRP1 and NIH 3T3 MDR1 cells.	fluorexon	136-143	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	195-199
9616142-2	1998	There was a good correlation between MRP expression and the modulatory effect of probenecid (a specific modulator of MRP) on the calcein efflux (r = .91, P = .0003) and between Pgp expression and the modulatory effect of CsA on calcein-AM uptake (r = .96, P < .0001).	fluorexon	129-136	MARCKS like 1	Homo sapiens	37-40
9616142-2	1998	There was a good correlation between MRP expression and the modulatory effect of probenecid (a specific modulator of MRP) on the calcein efflux (r = .91, P = .0003) and between Pgp expression and the modulatory effect of CsA on calcein-AM uptake (r = .96, P < .0001).	fluorexon	129-136	MARCKS like 1	Homo sapiens	117-120
9652375-4	1998	There was a significant relationship between the rank-order of drugs based on correlation with calcein/AM accumulation and Pgp/MRP mediated drug resistance suggesting that compounds being substrates for these pumps were identified.	fluorexon	95-102	phosphoglycolate phosphatase	Homo sapiens	123-126
9652375-4	1998	There was a significant relationship between the rank-order of drugs based on correlation with calcein/AM accumulation and Pgp/MRP mediated drug resistance suggesting that compounds being substrates for these pumps were identified.	fluorexon	95-102	ATP binding cassette subfamily C member 3	Homo sapiens	127-130
9334814-8	1997	Using 3H-daunomycin (3H-DM) and calcein as MRP substrates and probenecid (PRO), genistein (GEN), benzbromarone (BB), N-ethylmaleimide (NEM) and verapamil (VP) as MRP modulators, drug accumulation studies revealed a transporting activity of MRP that correlated significantly with the gene expression data.	fluorexon	32-39	ATP binding cassette subfamily C member 3	Homo sapiens	43-46
8945777-2	1996	As the ratio of CF-6 to lipid increased from 1 to 5, calcein retention in the liposomes increased from 70% up to 85% and a maximum retention was obtained at a ratio of more than 2.	fluorexon	53-60	ATP synthase peripheral stalk subunit F6	Homo sapiens	16-20
9096673-6	1997	Functional activity of MRP was assayed by analysing cellular accumulation of 3H-daunomycin (3H-DM) and calcein in response to MRP-modulators by beta-spectrometric and fluorescence-activated cell sorter analysis, respectively.	fluorexon	103-110	ATP binding cassette subfamily C member 3	Homo sapiens	126-129
8940397-6	1996	Bovine thecal cells expressing trkA receptors, but not cells lacking the receptors, respond to NGF with a reduction in the transfer of calcein, a fluorescent dye that passes through gap junctions.	fluorexon	135-142	neurotrophic receptor tyrosine kinase 1	Bos taurus	31-35
8940397-6	1996	Bovine thecal cells expressing trkA receptors, but not cells lacking the receptors, respond to NGF with a reduction in the transfer of calcein, a fluorescent dye that passes through gap junctions.	fluorexon	135-142	nerve growth factor	Bos taurus	95-98
9096673-6	1997	Functional activity of MRP was assayed by analysing cellular accumulation of 3H-daunomycin (3H-DM) and calcein in response to MRP-modulators by beta-spectrometric and fluorescence-activated cell sorter analysis, respectively.	fluorexon	103-110	ATP binding cassette subfamily C member 3	Homo sapiens	23-26
8847145-0	1995	On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP).	fluorexon	82-89	ATP binding cassette subfamily C member 3	Homo sapiens	145-184
8862725-4	1996	For a given Pgp-expressing MDR cell line, a Pgp modulator EC50 was defined as the concentration required to restore half of the calcein retention shown by similarly treated Par cells.	fluorexon	128-135	ATP binding cassette subfamily B member 1	Homo sapiens	12-15
8862725-4	1996	For a given Pgp-expressing MDR cell line, a Pgp modulator EC50 was defined as the concentration required to restore half of the calcein retention shown by similarly treated Par cells.	fluorexon	128-135	ATP binding cassette subfamily B member 1	Homo sapiens	44-47
8612802-1	1996	In this paper we demonstrate that the expression of the multidrug resistance-associated protein (MRP) in a variety of intact human tumour cells results in the ATP-dependent, mutually exclusive extrusion of both the acetoxymethyl ester and the free anion forms of the fluorescent dye calcein, as well as that of a fluorescent pyrenemaleimide-glutathione conjugate.	fluorexon	283-290	ATP binding cassette subfamily C member 3	Homo sapiens	56-95
8612802-1	1996	In this paper we demonstrate that the expression of the multidrug resistance-associated protein (MRP) in a variety of intact human tumour cells results in the ATP-dependent, mutually exclusive extrusion of both the acetoxymethyl ester and the free anion forms of the fluorescent dye calcein, as well as that of a fluorescent pyrenemaleimide-glutathione conjugate.	fluorexon	283-290	ATP binding cassette subfamily C member 3	Homo sapiens	97-100
8847145-0	1995	On the relationship between the probenecid-sensitive transport of daunorubicin or calcein and the glutathione status of cells overexpressing the multidrug resistance-associated protein (MRP).	fluorexon	82-89	ATP binding cassette subfamily C member 3	Homo sapiens	186-189
8847145-4	1995	Accumulation of calcein fluorescence was greatly reduced in the MRP-overexpressing human lung cancer cell lines COR-L23/R and MOR/R compared with their parental lines.	fluorexon	16-23	ATP binding cassette subfamily C member 3	Homo sapiens	64-67
8847145-4	1995	Accumulation of calcein fluorescence was greatly reduced in the MRP-overexpressing human lung cancer cell lines COR-L23/R and MOR/R compared with their parental lines.	fluorexon	16-23	opioid receptor mu 1	Homo sapiens	126-129
34959345-7	2021	We found that quercetin, quercetin-3-glucoside, narcissoside and ellagic acid inhibited the ATPase activity of Pgp and increased the accumulation of calcein and daunorubicin by Pgp-positive cells.	fluorexon	149-156	ATP binding cassette subfamily B member 1	Homo sapiens	177-180
8576100-4	1995	IL-1 alpha, but not IL-1 beta, caused an increase in the permeability of liposomes composed of phosphatidylserine (PS), at neutral and acidic pHs, as demonstrated by measuring the efflux of calcein.	fluorexon	190-197	interleukin 1 alpha	Homo sapiens	0-10
7909692-6	1994	The rate of calcein accumulation in human MDR1-expressing cells is significantly lower than in the control cells, while various drug-resistance reversing agents (verapamil, vinblastine, oligomycin, cyclosporin A and UIC2 monoclonal antibody) greatly increase calcein trapping only in the MDR1-expressing cells.	fluorexon	12-19	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
7909692-6	1994	The rate of calcein accumulation in human MDR1-expressing cells is significantly lower than in the control cells, while various drug-resistance reversing agents (verapamil, vinblastine, oligomycin, cyclosporin A and UIC2 monoclonal antibody) greatly increase calcein trapping only in the MDR1-expressing cells.	fluorexon	12-19	ATP binding cassette subfamily B member 1	Homo sapiens	288-292
8391000-10	1993	Communication between Cx26 TMEC transfectants and NMEC was asymetrical with preferential movement of calcein from TMEC to NMEC.	fluorexon	101-108	gap junction protein beta 2	Homo sapiens	22-26
1595080-6	1992	At pH 6 the outflow of calcein is promoted in the order heavy chain greater than toxin much greater than fragment beta 2, and the action of toxin is promoted by ganglioside.	fluorexon	23-30	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	114-120
34935973-9	2022	Granulosa microtissues displayed active GJIC function, as demonstrated by the Cx43-dependent diffusion of calcein fluorescent dye from microtissue surface to the core using high-throughput confocal microscopy in conjunction with our open-sourced automated image analysis tool.	fluorexon	106-113	gap junction protein alpha 1	Homo sapiens	78-82
7642714-9	1995	Transfer of calcein (MW = 623 D) was also reduced by approximately 50% in ROS/Cx45 cells, but passage of hydroxycoumarin carboxylic acid (HCCA; MW = 206 D) was only reduced by 35% as compared to ROS cells.	fluorexon	12-19	gap junction protein, gamma 1	Rattus norvegicus	78-82
7628644-0	1995	ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion.	fluorexon	24-31	ATP binding cassette subfamily C member 1	Homo sapiens	39-67
7628644-0	1995	ATP-dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion.	fluorexon	24-31	ATP binding cassette subfamily C member 1	Homo sapiens	69-72
7628644-2	1995	The transport of calcein by MRP is ATP-dependent and is inhibited by probenecid and vincristine.	fluorexon	17-24	ATP binding cassette subfamily C member 1	Homo sapiens	28-31
7628644-4	1995	In conclusion, ATP-dependent transport of calcein and possibly other organic anions by MRP is not inhibited by a large decrease of the intracellular GSH concentration, that inhibits daunorubicin efflux by MRP.	fluorexon	42-49	ATP binding cassette subfamily C member 1	Homo sapiens	87-90
7910563-4	1994	There was an inverse relationship between Pgp expression and calcein/AM accumulation, which increased dose-dependently in the presence of cyclosporin A (CsA) and the nonimmunosuppressive analogue SDZ PSC 833 (PSC) in the Pgp-expressing cell lines.	fluorexon	61-68	ATP binding cassette subfamily B member 1	Homo sapiens	42-45
7910563-4	1994	There was an inverse relationship between Pgp expression and calcein/AM accumulation, which increased dose-dependently in the presence of cyclosporin A (CsA) and the nonimmunosuppressive analogue SDZ PSC 833 (PSC) in the Pgp-expressing cell lines.	fluorexon	61-68	ATP binding cassette subfamily B member 1	Homo sapiens	221-224
7910563-6	1994	Calcein accumulation was also increased in Pgp-expressing cells by the addition of the Pgp substrate vincristine and the metabolic inhibitor potassium cyanide, KCN.	fluorexon	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	43-46
7910563-6	1994	Calcein accumulation was also increased in Pgp-expressing cells by the addition of the Pgp substrate vincristine and the metabolic inhibitor potassium cyanide, KCN.	fluorexon	0-7	ATP binding cassette subfamily B member 1	Homo sapiens	87-90
7910563-9	1994	The results indicate that microtiter-plate determination of calcein accumulation is a simple and sensitive method for functional determination of Pgp-mediated drug transport.	fluorexon	60-67	ATP binding cassette subfamily B member 1	Homo sapiens	146-149
7909692-1	1994	Acetoxymethyl ester (AM) derivatives of various fluorescent indicators (fura-2, fluo-3, indo-1, BCECF, calcein) are actively extruded by the multidrug transporter (MDR1, P-glycoprotein-Homolya, L. et al.	fluorexon	103-110	ATP binding cassette subfamily B member 1	Homo sapiens	164-168
1782834-1	1991	The present studies demonstrate that the intracellular fluorochromes calcein and hydroethidine can be used for quantification of effector-target conjugates involving cloned human natural killer (NK) or interleukin-2 (IL-2) activated human lymphokine activated killer (LAK) cells by dual color flow cytometry without potential artifacts that might result from extensive modification of effector and/or target cell membranes.	fluorexon	69-76	interleukin 2	Homo sapiens	202-215
1782834-1	1991	The present studies demonstrate that the intracellular fluorochromes calcein and hydroethidine can be used for quantification of effector-target conjugates involving cloned human natural killer (NK) or interleukin-2 (IL-2) activated human lymphokine activated killer (LAK) cells by dual color flow cytometry without potential artifacts that might result from extensive modification of effector and/or target cell membranes.	fluorexon	69-76	interleukin 2	Homo sapiens	217-221
1782834-1	1991	The present studies demonstrate that the intracellular fluorochromes calcein and hydroethidine can be used for quantification of effector-target conjugates involving cloned human natural killer (NK) or interleukin-2 (IL-2) activated human lymphokine activated killer (LAK) cells by dual color flow cytometry without potential artifacts that might result from extensive modification of effector and/or target cell membranes.	fluorexon	69-76	interleukin 2	Homo sapiens	239-249
34794579-2	2021	In this study, we describe the development of a reliable and novel fluorescent assay for ALP detection based on chitosan carbon dots (C-CDs, peak emission, 412 nm) and calcein (peak emission, 512 nm).	fluorexon	168-175	alkaline phosphatase, placental	Homo sapiens	89-92
34794579-4	2021	Utilizing the ALP-triggered generation of phosphate ions (PO43-) from the substrate p-nitrophenyl phosphate (pNPP), the Eu3+ ions bind PO43- (which shows a higher affinity toward Eu3+ than calcein), and the fluorescence of calcein is recovered.	fluorexon	189-196	alkaline phosphatase, placental	Homo sapiens	14-17
34794579-4	2021	Utilizing the ALP-triggered generation of phosphate ions (PO43-) from the substrate p-nitrophenyl phosphate (pNPP), the Eu3+ ions bind PO43- (which shows a higher affinity toward Eu3+ than calcein), and the fluorescence of calcein is recovered.	fluorexon	223-230	alkaline phosphatase, placental	Homo sapiens	14-17
34254370-6	2021	In vivo, Scara3 adeno-associated virus was injected into intra-bone marrow of the aged mice and ovariectomized (OVX) mice whose phenotypes were confirmed by micro-CT, calcein double labelling and immunochemistry (HE and OCN staining).	fluorexon	167-174	scavenger receptor class A member 3	Homo sapiens	9-15
35416707-7	2022	A higher frequency of NKp46-expressing CD94+ T cells correlated with significantly increased peripheral blood mononuclear cell (PBMC) cytotoxic activity via calcein release assay.	fluorexon	157-164	killer cell lectin like receptor D1	Canis lupus familiaris	39-43
32061744-4	2020	The effects of selected, widely prescribed, therapeutic drugs on ABCB1, ABCC5 and ABCG2 activities were determined by measuring intracellular levels of calcein, GS-MF, and Hoechst 33342 respectively in primary porcine brain endothelial cells (PBECs).	fluorexon	152-159	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	82-87
3104321-3	1987	At pH values below about 5, TNF bound to phospholipid liposomes composed of mixtures of phosphatidyl-serine and phosphatidylcholine in molar ratios of 2:1 and 1:2 and caused rapid release of calcein.	fluorexon	191-198	tumor necrosis factor	Homo sapiens	28-31
33910062-7	2021	DIM has increased the intracellular accumulation of Hoechst and Calcein, the substrates of P-gp and MRP1, respectively, in breast cancer cells.	fluorexon	64-71	phosphoglycolate phosphatase	Homo sapiens	91-95
33910062-7	2021	DIM has increased the intracellular accumulation of Hoechst and Calcein, the substrates of P-gp and MRP1, respectively, in breast cancer cells.	fluorexon	64-71	ATP binding cassette subfamily C member 1	Homo sapiens	100-104
32953942-0	2020	Calcein Release Assay to Measure Membrane Permeabilization by Recombinant Alpha-Synuclein.	fluorexon	0-7	synuclein alpha	Homo sapiens	74-89
35381435-5	2022	I-CRP-treated human NK cells exhibited an increased degranulation activity against K562 target cells, as shown by CD107a assay, and this correlates with cytotoxicity against K562 cells observed in calcein release assay.	fluorexon	197-204	C-reactive protein	Homo sapiens	2-5
33349973-8	2021	The ABCB1 inhibitor zosuquidar, the ABCG2 inhibitor Ko143, and the ABCC1 inhibitor MK571 increased calcein retention.	fluorexon	99-106	ATP binding cassette subfamily B member 1	Homo sapiens	4-9
33349973-8	2021	The ABCB1 inhibitor zosuquidar, the ABCG2 inhibitor Ko143, and the ABCC1 inhibitor MK571 increased calcein retention.	fluorexon	99-106	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	36-41
33349973-8	2021	The ABCB1 inhibitor zosuquidar, the ABCG2 inhibitor Ko143, and the ABCC1 inhibitor MK571 increased calcein retention.	fluorexon	99-106	ATP binding cassette subfamily C member 1	Homo sapiens	67-72
31173907-10	2019	Vital staining of gpr137ba-/- fish with calcein and alizarin red indicated that bone formation in the mutants is also increased, suggesting high bone turnover.	fluorexon	40-47	G protein-coupled receptor 137c	Danio rerio	18-26
33463192-7	2020	The fluorescent results showed that HSA-PEG and Tf-PEG liposomes were more sonosensitive (showing higher calcein release following the exposure to pulsed LFUS) compared to the control pegylated liposomes, thus adding more acoustic benefits to their targeting efficacy.	fluorexon	105-112	albumin	Homo sapiens	36-39
33463192-7	2020	The fluorescent results showed that HSA-PEG and Tf-PEG liposomes were more sonosensitive (showing higher calcein release following the exposure to pulsed LFUS) compared to the control pegylated liposomes, thus adding more acoustic benefits to their targeting efficacy.	fluorexon	105-112	transferrin	Homo sapiens	48-50
32922485-5	2020	Different LED wavelengths (blue, green and red) were used for triggering release of calcein from nanoliposome.	fluorexon	84-91	small integral membrane protein 10 like 2A	Homo sapiens	10-13
32056006-7	2020	ABCB1 function was studied via calcein influx assay under treatment with known ABCB1 inhibitors (verapamil, tariquidar) as well as the kinase inhibitor bosutinib.	fluorexon	31-38	ATP binding cassette subfamily B member 1	Homo sapiens	0-5
31942789-4	2020	Comparing calcein retention against intact Env expression (via Ab 35O22) on individual cells revealed effects proportional to Env expression.	fluorexon	10-17	endogenous retrovirus group K member 20	Homo sapiens	126-129
31942789-5	2020	"Low-Env" cells experienced transient poration and calcein leakage, while "High-Env" cells were killed.	fluorexon	51-58	endogenous retrovirus group K member 20	Homo sapiens	5-8
31401398-4	2019	Using calcein as a fluorescent reporter in a high content uptake assay, we recently reported the identification of 12 MRP1 inhibitors after screening an anti-cancer library of 386 compounds.	fluorexon	6-13	ATP binding cassette subfamily C member 1	Homo sapiens	118-122
31552025-9	2019	Double calcein labeling revealed a significant decrease in dynamic synthesis and mineralization of bone in lambda5-/- mice.	fluorexon	7-14	immunoglobulin lambda-like polypeptide 1	Mus musculus	107-114
30668439-4	2019	RESULTS: The resveratrol influenced P-gp and MRP1 efflux functions whereby it increased rhodamine 123 with calcein accumulation in concentration-dependent manner (1 - 500 microM) in the Caco-2 cell lines and inhibited the effluxes of both the substrates also as concentration-dependent phenomenon (10 - 100 microM) in the p-gp overexpressing CEM/ADR5000 cells through FACS (full form).	fluorexon	107-114	MDM4 regulator of p53	Homo sapiens	45-49
31063354-1	2019	A metal-organic gel (metallogel) based on the new tetracarboxyl ligand N1, N4-(diterephthalic acid)terephthalamide in combination with chromium(III) has been converted into its xero- and aerogel and demonstrated to have excellent specific sorption properties for dyes in its metallogel state, where fuchsine is adsorbed faster than the two other dyes, calcein and disulfine blue, and for water, sulfur dioxide and carbon dioxide in its xero- and aerogel state.	fluorexon	352-359	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	144-147
31384242-8	2019	3-Hydroxyflavone also exhibited antioxidative properties as it reduced intracellular reactive oxygen species and promoted the activities of ABC transporters as it reduced retention of Calcein in Ag NM-exposed THP-1 macrophages.	fluorexon	184-191	GLI family zinc finger 2	Homo sapiens	209-214
29671386-3	2019	K237-TSL encapsulation with calcein was synthesized and used to determine the cellular uptake of TSL.	fluorexon	28-35	TSL	Homo sapiens	5-8
29671386-3	2019	K237-TSL encapsulation with calcein was synthesized and used to determine the cellular uptake of TSL.	fluorexon	28-35	TSL	Homo sapiens	97-100
29498663-6	2018	Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines.	fluorexon	143-150	ATP binding cassette subfamily B member 1	Homo sapiens	96-110
29581879-8	2018	In contrast, the normalized molar efflux of calcein from pre-loaded cells into the medium after electropermeabilization is roughly equivalent to the influx of YO-PRO-1 and propidium.	fluorexon	44-51	lamin A/C	Homo sapiens	162-167
29392933-1	2018	A simple and cost-effective fluorescence immunoassay for the sensitive quantitation of disease biomarker alpha-fetoprotein (AFP) has been developed based on the phosphate-triggered fluorescence turn-on detection of alkaline phosphatase (ALP), with the reversible binding between calcein and Ce3+ as a signaling element.	fluorexon	279-286	alpha fetoprotein	Homo sapiens	105-122
29392933-1	2018	A simple and cost-effective fluorescence immunoassay for the sensitive quantitation of disease biomarker alpha-fetoprotein (AFP) has been developed based on the phosphate-triggered fluorescence turn-on detection of alkaline phosphatase (ALP), with the reversible binding between calcein and Ce3+ as a signaling element.	fluorexon	279-286	alpha fetoprotein	Homo sapiens	124-127
29392933-1	2018	A simple and cost-effective fluorescence immunoassay for the sensitive quantitation of disease biomarker alpha-fetoprotein (AFP) has been developed based on the phosphate-triggered fluorescence turn-on detection of alkaline phosphatase (ALP), with the reversible binding between calcein and Ce3+ as a signaling element.	fluorexon	279-286	alkaline phosphatase, placental	Homo sapiens	215-235
29392933-3	2018	The ALP-catalyzed hydrolysis of p-nitrophenyl phosphate leads to the formation of p-nitrophenol and inorganic orthophosphate, and the newly formed orthophosphate could potently combine with Ce3+ due to the higher affinity, thus, recovering the fluorescence of calcein.	fluorexon	260-267	alkaline phosphatase, placental	Homo sapiens	4-7
30232176-4	2018	Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells.	fluorexon	113-120	ATP binding cassette subfamily C member 1	Homo sapiens	83-87
30232176-4	2018	Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells.	fluorexon	113-120	ATP binding cassette subfamily C member 1	Homo sapiens	131-135
30232176-4	2018	Calcitriol and calcipotriol consistently displayed a potent inhibitory activity on MRP1-mediated doxorubicin and calcein efflux in MRP1-overexpressing H69AR and HEK293/MRP1 cells.	fluorexon	113-120	ATP binding cassette subfamily C member 1	Homo sapiens	131-135
30232176-6	2018	Such collateral sensitivity, however, was not observed in HEK293/P-gp and HEK293/BCRP cells, although the vitamin D3 analogs inhibited calcein efflux in P-gp-overexpressing cells, and mitoxantrone efflux in BCRP-overexpressing cells.	fluorexon	135-142	phosphoglycolate phosphatase	Homo sapiens	153-157
30114293-6	2018	Efavirenz also reduced the efflux of calcein from MDCK-MRP2 cells, but had a rather weak inhibitory effect on Hoechst 33342 accumulation in MDCK-MDR1 and MDCK-BCRP cells.	fluorexon	37-44	ATP binding cassette subfamily C member 2	Canis lupus familiaris	55-59
29498663-6	2018	Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines.	fluorexon	143-150	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
32264571-5	2017	Amphiphilic self-assembled PeptiSomes in water were capable of disassembling and releasing the encapsulated self-quenched fluorescence dye (calcein) via enzymatic activation by MT1-MMP.	fluorexon	140-147	matrix metallopeptidase 14	Homo sapiens	177-184
30032135-10	2018	Calcein staining revealed that mapk7-knockdown delayed the ossification of the vertebrae.	fluorexon	0-7	mitogen-activated protein kinase 7	Danio rerio	31-36