PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1963774-0	1990	Effect of staurosporine on the induction of actin/gelsolin in PMA-treated HL-60 cells.	Staurosporine	10-23	gelsolin	Homo sapiens	50-58
1963774-1	1990	Staurosporine, an inhibitor of protein kinase C (PKC), has been shown to inhibit the induction of two cytosolic proteins, p42 and p91, during the differentiation of HL-60 cells initiated by PMA treatment.	Staurosporine	0-13	cyclin dependent kinase 20	Homo sapiens	122-125
2121569-11	1990	Staurosporine, a protein kinase C inhibitor, blocked glyburide-, tolbutamide-, and insulin-stimulated glucose uptake.	Staurosporine	0-13	insulin	Homo sapiens	83-90
2233279-2	1990	In both model systems, H-7, sangivamycin, and staurosporine, inhibitors of the catalytic domain of PKC, each effectively blocked insulin and PMA-stimulated hexose uptake at similar concentrations.	Staurosporine	46-59	protein kinase C, gamma	Rattus norvegicus	99-102
2174163-3	1990	In addition, inhibitors of PKC (H7 and staurosporine) block the induction of antiviral activity by IFN against vesicular stomatitis virus.	Staurosporine	39-52	interferon alpha 1	Homo sapiens	99-102
2170380-12	1990	The inclusion of staurosporine, a protein kinase C inhibitor, blocked VP-induced [3H]myristoyl-PEt formation by 88%.	Staurosporine	17-30	arginine vasopressin	Rattus norvegicus	70-72
2170389-5	1990	Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation.	Staurosporine	43-56	angiotensinogen	Rattus norvegicus	190-204
2170389-5	1990	Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation.	Staurosporine	43-56	coagulation factor II	Rattus norvegicus	215-223
1976698-6	1990	Conversely, FMLP-induced aggregation is enhanced and prolonged by staurosporine whereas the associated minimal phosphorylation event is further diminished by staurosporine.	Staurosporine	66-79	formyl peptide receptor 1	Homo sapiens	12-16
1976698-6	1990	Conversely, FMLP-induced aggregation is enhanced and prolonged by staurosporine whereas the associated minimal phosphorylation event is further diminished by staurosporine.	Staurosporine	158-171	formyl peptide receptor 1	Homo sapiens	12-16
2170389-5	1990	Addition of the protein kinase C inhibitor staurosporine or down-regulation of protein kinase C by prolonged incubation with phorbol 12-myristate 13-acetate partially reduced the effects of angiotensin II and alpha-thrombin and completely blunted the phorbol 12-myristate 13-acetate-induced stimulation of Na+/K+/Cl- cotransport but did not affect EGF-induced stimulation.	Staurosporine	43-56	epidermal growth factor like 1	Rattus norvegicus	348-351
2171676-7	1990	In this paper, we now report that while neutrophils treated with 15 nM staurosporine and PMA release little O2-, cells in the presence of these compounds can be stimulated to release near normal quantities of O2- by the subsequent addition of fMLP.	Staurosporine	71-84	formyl peptide receptor 1	Homo sapiens	243-247
1976698-11	1990	Of note, staurosporine was also found to cause selective release of specific granules with concomitant increase in surface display of CD11b/CD18.	Staurosporine	9-22	integrin subunit alpha M	Homo sapiens	134-139
1976698-11	1990	Of note, staurosporine was also found to cause selective release of specific granules with concomitant increase in surface display of CD11b/CD18.	Staurosporine	9-22	integrin subunit beta 2	Homo sapiens	140-144
2121048-5	1990	Both PMA-stimulated AA release and COX activity were reduced by the protein kinase C inhibitor staurosporine (STP).	Staurosporine	95-108	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	35-38
2121048-5	1990	Both PMA-stimulated AA release and COX activity were reduced by the protein kinase C inhibitor staurosporine (STP).	Staurosporine	110-113	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	35-38
2171676-8	1990	Surprisingly, staurosporine (15 nM) reduced the incorporation of 32P into the 47 kDa protein in fMLP stimulated cells at least as effectively as H-7, yet, while the staurosporine treated cells released substantial amounts of O2-, the cells treated with H-7 did not.	Staurosporine	14-27	formyl peptide receptor 1	Homo sapiens	96-100
2171676-8	1990	Surprisingly, staurosporine (15 nM) reduced the incorporation of 32P into the 47 kDa protein in fMLP stimulated cells at least as effectively as H-7, yet, while the staurosporine treated cells released substantial amounts of O2-, the cells treated with H-7 did not.	Staurosporine	165-178	formyl peptide receptor 1	Homo sapiens	96-100
2283681-6	1990	Addition of the PKC inhibitor staurosporine (1 and 10 nM) completely inhibited the action of TPA on EGF-induced [Ca2+]i changes.	Staurosporine	30-43	epidermal growth factor	Homo sapiens	100-103
2386936-2	1990	Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF, 43% decrease; 1 ng/ml of TNF + 20 nM staurosporine, 94%), whereas the cytotoxic action on that cell line induced by 10 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA), which was known to be an activator of PKC, was partially inhibited by staurosporine.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	113-116
2117926-6	1990	The HDC activity increased 1.8-fold when the cells were stimulated by phorbol myristate acetate, which is known to activate protein kinase C, and this increase was blocked by staurosporine, a potent inhibitor of protein kinase C.	Staurosporine	175-188	histidine decarboxylase	Homo sapiens	4-7
2386936-1	1990	We have examined the effect of the protein kinase C (PKC) inhibitor, staurosporine, on tumor necrosis factor (TNF)-induced cytotoxic action and augmentation of human immunodeficiency virus (HIV) expression on the chronically HIV-infected T-cell line, MOLT-4/HIV (HTLV-IIIB strain).	Staurosporine	69-82	tumor necrosis factor	Homo sapiens	110-113
2386936-2	1990	Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF, 43% decrease; 1 ng/ml of TNF + 20 nM staurosporine, 94%), whereas the cytotoxic action on that cell line induced by 10 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA), which was known to be an activator of PKC, was partially inhibited by staurosporine.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	76-79
2167234-3	1990	In addition, 100-200 nM staurosporine, a more potent inhibitor of protein kinase C, also completely suppressed GM-CSA from IL-1 beta- and TNF alpha-induced fibroblasts.	Staurosporine	24-37	interleukin 1 beta	Homo sapiens	123-132
2167234-3	1990	In addition, 100-200 nM staurosporine, a more potent inhibitor of protein kinase C, also completely suppressed GM-CSA from IL-1 beta- and TNF alpha-induced fibroblasts.	Staurosporine	24-37	tumor necrosis factor	Homo sapiens	138-147
2402510-3	1990	Addition of phorbol 12-myristate 13-acetate resulted in increased flagellar motility that was blocked by known PKC inhibitors such as sphingosine, staurosporine, and 1-(5-isoquinoylinylsulfonyl)-2-methylpiperazine.	Staurosporine	147-160	proline rich transmembrane protein 2	Homo sapiens	111-114
2165851-2	1990	However, staurosporine induced irritation on mouse ear and histidine decarboxylase activity in mouse skin.	Staurosporine	9-22	histidine decarboxylase	Mus musculus	59-82
1696432-8	1990	Enhancement of amylase secretion by submaximal concentrations of GTP gamma S or TPA was inhibited by the protein kinase C inhibitor staurosporine.	Staurosporine	132-145	promotion susceptibility QTL 1	Mus musculus	65-83
2117917-3	1990	We report here that the protein kinase C inhibitor staurosporine enhanced the IL-1 alpha-induced increase in [Fru(2,6)P2] and PGE production by RSC, whereas in similar concentrations (3-30 nM) this inhibitor decreased the TPA-induced stimulation of these parameters.	Staurosporine	51-64	interleukin 1 alpha	Homo sapiens	78-88
2117917-4	1990	Staurosporine produced a similar enhancement of the response to IL-1 alpha by normal human dermal fibroblasts.	Staurosporine	0-13	interleukin 1 alpha	Homo sapiens	64-74
2117917-5	1990	The increased PGE production provoked by tumour necrosis factor alpha (TNF alpha) in RSC was also augmented by staurosporine, but, in contrast, the increases in cellular [Fru(2,6)P2] induced by transforming growth factor beta (TGF beta) and interferon-gamma (IFN-gamma) were diminished.	Staurosporine	111-124	tumor necrosis factor	Homo sapiens	71-80
2117917-6	1990	Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha).	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	105-115
2117917-6	1990	Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha).	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	151-161
2117917-6	1990	Thus the protein kinase C inhibitor staurosporine discriminates not only between the effects produced by IL-1 alpha and TPA, but also between those of IL-1 alpha and two other cytokines (but not between IL-1 alpha and TNF alpha).	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	151-161
2117917-7	1990	These findings suggest that IL-1 alpha and probably TNF alpha act via an intracellular mechanism different from that mediating the action of TPA, TGF-beta and IFN-gamma, and provide evidence that staurosporine is capable of amplifying the IL-1 signal.	Staurosporine	196-209	interleukin 1 alpha	Homo sapiens	28-38
2117917-7	1990	These findings suggest that IL-1 alpha and probably TNF alpha act via an intracellular mechanism different from that mediating the action of TPA, TGF-beta and IFN-gamma, and provide evidence that staurosporine is capable of amplifying the IL-1 signal.	Staurosporine	196-209	tumor necrosis factor	Homo sapiens	52-61
2117917-7	1990	These findings suggest that IL-1 alpha and probably TNF alpha act via an intracellular mechanism different from that mediating the action of TPA, TGF-beta and IFN-gamma, and provide evidence that staurosporine is capable of amplifying the IL-1 signal.	Staurosporine	196-209	transforming growth factor beta 1	Homo sapiens	146-154
2117917-7	1990	These findings suggest that IL-1 alpha and probably TNF alpha act via an intracellular mechanism different from that mediating the action of TPA, TGF-beta and IFN-gamma, and provide evidence that staurosporine is capable of amplifying the IL-1 signal.	Staurosporine	196-209	interferon gamma	Homo sapiens	159-168
2169942-9	1990	For staurosporine-induced inhibition of O2- release, the order of potency changed to fluoride greater than DiC8, PMA greater than HAGG, fMLP greater than opsonized zymosan.	Staurosporine	4-17	formyl peptide receptor 1	Homo sapiens	136-140
2169942-12	1990	Staurosporine at low concentrations increased the fMLP-stimulated O2- response by 100%, the maximum effect occurring at 35 nM.	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	50-54
2196173-11	1990	The results also demonstrate that the induction of Na+ influx by CSF-1 is inhibited by the protein kinase C inhibitors staurosporine and the isoquinoline derivative H7, but not by HA1004.	Staurosporine	119-132	colony stimulating factor 1	Homo sapiens	65-70
1697562-5	1990	In all cases the increments were shown to be dependent on protein kinase C (PKC), as evidenced by their inhibition with staurosporine, a potent inhibitor of PKC activation.	Staurosporine	120-133	proline rich transmembrane protein 2	Homo sapiens	58-74
1697562-5	1990	In all cases the increments were shown to be dependent on protein kinase C (PKC), as evidenced by their inhibition with staurosporine, a potent inhibitor of PKC activation.	Staurosporine	120-133	proline rich transmembrane protein 2	Homo sapiens	76-79
1697562-5	1990	In all cases the increments were shown to be dependent on protein kinase C (PKC), as evidenced by their inhibition with staurosporine, a potent inhibitor of PKC activation.	Staurosporine	120-133	proline rich transmembrane protein 2	Homo sapiens	157-160
2386487-7	1990	Pretreatment of platelets with the PKC inhibitors K252a or staurosporine potentiates DAG production in response to thrombin (3-4-fold) when using concentrations required to inhibit platelet PKC (1-10 microM).	Staurosporine	59-72	coagulation factor II, thrombin	Homo sapiens	115-123
2169600-4	1990	Staurosporine inhibited the neurite outgrowth induced by NGF, but not that by Bt2cCMP.	Staurosporine	0-13	nerve growth factor	Rattus norvegicus	57-60
2386936-2	1990	Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF, 43% decrease; 1 ng/ml of TNF + 20 nM staurosporine, 94%), whereas the cytotoxic action on that cell line induced by 10 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA), which was known to be an activator of PKC, was partially inhibited by staurosporine.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	113-116
2386936-2	1990	Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF, 43% decrease; 1 ng/ml of TNF + 20 nM staurosporine, 94%), whereas the cytotoxic action on that cell line induced by 10 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA), which was known to be an activator of PKC, was partially inhibited by staurosporine.	Staurosporine	155-168	tumor necrosis factor	Homo sapiens	76-79
2386936-2	1990	Staurosporine enhanced the decrease in the number of viable cells caused by TNF treatment for 3 days (1 ng/ml of TNF, 43% decrease; 1 ng/ml of TNF + 20 nM staurosporine, 94%), whereas the cytotoxic action on that cell line induced by 10 ng/ml of 12-O-tetradecanoylphorbol-13-acetate (TPA), which was known to be an activator of PKC, was partially inhibited by staurosporine.	Staurosporine	360-373	tumor necrosis factor	Homo sapiens	76-79
2386936-3	1990	In addition, staurosporine augmented the TNF cytotoxic activity against other cell lines including HIV-uninfected U937 cells(100 ng/ml of TNF, 53% decrease in the number of viable cells; 100 ng/ml of TNF + 5 nM staurosporine, 86%).	Staurosporine	13-26	tumor necrosis factor	Homo sapiens	41-44
2386936-3	1990	In addition, staurosporine augmented the TNF cytotoxic activity against other cell lines including HIV-uninfected U937 cells(100 ng/ml of TNF, 53% decrease in the number of viable cells; 100 ng/ml of TNF + 5 nM staurosporine, 86%).	Staurosporine	13-26	tumor necrosis factor	Homo sapiens	138-141
2386936-3	1990	In addition, staurosporine augmented the TNF cytotoxic activity against other cell lines including HIV-uninfected U937 cells(100 ng/ml of TNF, 53% decrease in the number of viable cells; 100 ng/ml of TNF + 5 nM staurosporine, 86%).	Staurosporine	13-26	tumor necrosis factor	Homo sapiens	138-141
2386936-7	1990	These results suggest that TPA and TNF facilitate HIV replication by different pathways and that staurosporine augments TNF cytotoxicity by possible suppression of PKC activity in both HIV-infected and uninfected cells.	Staurosporine	97-110	tumor necrosis factor	Homo sapiens	120-123
2163893-4	1990	Furthermore, they demonstrate that staurosporine enhances GnRH stimulus-secretion coupling.	Staurosporine	35-48	Progonadoliberin-1	Ovis aries	58-62
2163893-0	1990	Staurosporine enhances gonadotrophin-releasing hormone-stimulated luteinizing hormone secretion.	Staurosporine	0-13	Progonadoliberin-1	Ovis aries	23-54
2163893-2	1990	Under the same conditions staurosporine enhanced gonadotrophin-releasing hormone (GnRH)-stimulated LH exocytosis without altering the EC50 of GnRH and without affecting basal LH exocytosis.	Staurosporine	26-39	Progonadoliberin-1	Ovis aries	49-80
2163893-2	1990	Under the same conditions staurosporine enhanced gonadotrophin-releasing hormone (GnRH)-stimulated LH exocytosis without altering the EC50 of GnRH and without affecting basal LH exocytosis.	Staurosporine	26-39	Progonadoliberin-1	Ovis aries	82-86
2117475-8	1990	Thrombin-induced PAI-1 production was inhibited to more than 80% by H7 (10 microM) and to about 50% by staurosporine, whereas PMA-induced PAI-1 production was not inhibited by staurosporine, and only to about 50% by higher doses of H7 (30 microM).	Staurosporine	103-116	coagulation factor II, thrombin	Homo sapiens	0-8
2117475-8	1990	Thrombin-induced PAI-1 production was inhibited to more than 80% by H7 (10 microM) and to about 50% by staurosporine, whereas PMA-induced PAI-1 production was not inhibited by staurosporine, and only to about 50% by higher doses of H7 (30 microM).	Staurosporine	103-116	serpin family E member 1	Homo sapiens	17-22
2401859-9	1990	Like H7, staurosporine, polymixin B, and sphingosine inhibit only by half the stimulatory effect of GH on the expression of the LPL gene.	Staurosporine	9-22	lipoprotein lipase	Mus musculus	128-131
2172518-15	1990	Staurosporine inhibited the effect of NGF on 125I-omega-CgTX binding.	Staurosporine	0-13	nerve growth factor	Rattus norvegicus	38-41
2112411-7	1990	The thrombin-induced increase in phosphorylation was inhibited by pretreating platelets with prostacyclin or with staurosporin, a specific protein kinase C inhibitor.	Staurosporine	114-126	coagulation factor II, thrombin	Homo sapiens	4-12
2363701-3	1990	We show here that the protein kinase C (PKC) inhibitors staurosporine and sphingosine can reverse the effects of phorbol dibutyrate on the frequency of free-Ca transients induced by phenylephrine or vasopressin.	Staurosporine	56-69	arginine vasopressin	Rattus norvegicus	199-210
2185942-1	1990	The protein kinase C (PKC) inhibitor staurosporine was found to dramatically alter the actin microfilament cytoskeleton of a variety of cultured cells, including PTK2 epithelial cells, Swiss 3T3 fibroblasts, and human foreskin fibroblasts.	Staurosporine	37-50	protein tyrosine kinase 2	Homo sapiens	162-166
2185942-2	1990	For example, PTK2 cells exposed to 20 nM staurosporine exhibited a progressive thinning and loss of cytoplasmic actin microfilament bundles over a 60-min period.	Staurosporine	41-54	PTK2 protein tyrosine kinase 2	Mus musculus	13-17
2113537-13	1990	The protein kinase C inhibitors H-7 and staurosporine ablated the enhancing effect of PMA on thrombin-stimulated PGI2 and PAF biosynthesis.	Staurosporine	40-53	coagulation factor II, thrombin	Homo sapiens	93-101
2113537-13	1990	The protein kinase C inhibitors H-7 and staurosporine ablated the enhancing effect of PMA on thrombin-stimulated PGI2 and PAF biosynthesis.	Staurosporine	40-53	PCNA clamp associated factor	Homo sapiens	122-125
1972968-10	1990	Staurosporin reversed the stimulation by PTH of the PHA-induced lymphocyte proliferation.	Staurosporine	0-12	parathyroid hormone	Homo sapiens	41-44
2186042-5	1990	Preincubation of Jurkat cells with protein kinase inhibitor H7 or staurosporine blocked PK-C activation by either TNF or phorbol 12-myristate 12-acetate (PMA).	Staurosporine	66-79	proline rich transmembrane protein 2	Homo sapiens	88-92
2186042-5	1990	Preincubation of Jurkat cells with protein kinase inhibitor H7 or staurosporine blocked PK-C activation by either TNF or phorbol 12-myristate 12-acetate (PMA).	Staurosporine	66-79	tumor necrosis factor	Homo sapiens	114-117
2185243-5	1990	Similarly, inhibition of PKC-epsilon by staurosporine and H-7 parallels inhibition of other PKC isotypes.	Staurosporine	40-53	protein kinase C epsilon	Homo sapiens	25-36
2185243-5	1990	Similarly, inhibition of PKC-epsilon by staurosporine and H-7 parallels inhibition of other PKC isotypes.	Staurosporine	40-53	protein kinase C alpha	Homo sapiens	25-28
2167317-7	1990	In contrast, induction of PDGF A-chain mRNA is almost totally inhibited by staurosporine.	Staurosporine	75-88	platelet derived growth factor subunit A	Homo sapiens	26-38
2163893-8	1990	Based on these results we hypothesize that staurosporine inhibits a protein kinase which is activated by GnRH and which negatively modulates GnRH stimulus-secretion coupling.	Staurosporine	43-56	Progonadoliberin-1	Ovis aries	105-109
2163893-8	1990	Based on these results we hypothesize that staurosporine inhibits a protein kinase which is activated by GnRH and which negatively modulates GnRH stimulus-secretion coupling.	Staurosporine	43-56	Progonadoliberin-1	Ovis aries	141-145
2141572-1	1990	We studied the effect of staurosporine, a potent inhibitor of protein kinase C (PKC) activity, on the phorbol ester- or monoclonal antibody (mAb)-induced modulation of CD3 and CD4 surface antigens.	Staurosporine	25-38	CD4 molecule	Homo sapiens	176-179
1970444-5	1990	The effects of TPA on syncytia formation and on CD4 expression were specifically interfered with by nontoxic doses of blockers of protein kinase C (PKC) such as staurosporine and H7.	Staurosporine	161-174	CD4 molecule	Homo sapiens	48-51
1970444-5	1990	The effects of TPA on syncytia formation and on CD4 expression were specifically interfered with by nontoxic doses of blockers of protein kinase C (PKC) such as staurosporine and H7.	Staurosporine	161-174	proline rich transmembrane protein 2	Homo sapiens	130-146
1970444-5	1990	The effects of TPA on syncytia formation and on CD4 expression were specifically interfered with by nontoxic doses of blockers of protein kinase C (PKC) such as staurosporine and H7.	Staurosporine	161-174	proline rich transmembrane protein 2	Homo sapiens	148-151
2159293-6	1990	Staurosporine completely inhibited phorbol 12,13-dibutyrate or thrombin-stimulated production of phosphatidylinositol 3,4-bisphosphate.	Staurosporine	0-13	coagulation factor II, thrombin	Homo sapiens	63-71
2324095-4	1990	In addition, induction of PAI-2 synthesis by TNF was blocked by two PKC inhibitors, staurosporine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride.	Staurosporine	84-97	serpin family B member 2	Homo sapiens	26-31
2324095-4	1990	In addition, induction of PAI-2 synthesis by TNF was blocked by two PKC inhibitors, staurosporine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride.	Staurosporine	84-97	tumor necrosis factor	Homo sapiens	45-48
2324095-6	1990	Staurosporine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride also inhibited both TNF- and phorbol myristate acetate-induced PAI-2 mRNA accumulation.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	100-103
2324095-6	1990	Staurosporine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride also inhibited both TNF- and phorbol myristate acetate-induced PAI-2 mRNA accumulation.	Staurosporine	0-13	serpin family B member 2	Homo sapiens	143-148
2158320-0	1990	Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor.	Staurosporine	0-13	PCNA clamp associated factor	Homo sapiens	135-161
2182714-4	1990	In our study, it is shown that stimulation of lymphocytes with activators of protein kinase C (PKC), such as PMA or 1-oleoyl 2-acetyl-glycerol, results in the nearly complete loss of surface expression of gp90 within 1 h. Pretreatment of the cells with H-7 or staurosporine, PKC inhibitors, but not HA1004, a general protein kinase inhibitor, prevents the loss of gp90MEL-14.	Staurosporine	260-273	galectin 3 binding protein	Homo sapiens	205-209
1695458-5	1990	Inhibition of protein kinase C (PKC) by staurosporine (STSP) resulted in partial inhibition of the anti-IgE-induced HR, whereas inhibition of a PKC-independent pathway by wortmannin (WTM) totally blocked the anti-IgE induced histamine release.	Staurosporine	40-53	immunoglobulin heavy constant epsilon	Homo sapiens	104-107
1695458-5	1990	Inhibition of protein kinase C (PKC) by staurosporine (STSP) resulted in partial inhibition of the anti-IgE-induced HR, whereas inhibition of a PKC-independent pathway by wortmannin (WTM) totally blocked the anti-IgE induced histamine release.	Staurosporine	55-59	immunoglobulin heavy constant epsilon	Homo sapiens	104-107
2155237-5	1990	The NGF-stimulated kinase activity is unaffected by direct addition to the assay of the heat-stable cAMP-dependent kinase peptide inhibitor, staurosporine, or K-252A, is slightly stimulated by heparin and is inhibited by sodium fluoride and calcium ions.	Staurosporine	141-154	nerve growth factor	Rattus norvegicus	4-7
2109710-0	1990	Mechanism of action of gonadotropin releasing hormone upon gonadotropin secretion: involvement of protein kinase C as revealed by staurosporine inhibition and enzyme depletion.	Staurosporine	130-143	protein kinase C, gamma	Rattus norvegicus	98-114
2109710-2	1990	A relatively selective PKC inhibitor, staurosporine, inhibited both GnRH- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced luteinizing hormone (LH) release with half-maximal inhibition (IC50) of about 80 nM.	Staurosporine	38-51	protein kinase C, gamma	Rattus norvegicus	23-26
2109710-2	1990	A relatively selective PKC inhibitor, staurosporine, inhibited both GnRH- and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced luteinizing hormone (LH) release with half-maximal inhibition (IC50) of about 80 nM.	Staurosporine	38-51	gonadotropin releasing hormone 1	Rattus norvegicus	68-72
2319459-7	1990	Staurosporine (0.1-0.3 microM), a putative PKC inhibitor, significantly inhibited PDB-induced contractile and MLC phosphorylation responses.	Staurosporine	0-13	myosin light chain 1	Sus scrofa	110-113
2319459-8	1990	Tonic histamine (3 microM)- and KCl-induced contractile and MLC-phosphorylation responses were inhibited by the same concentrations of staurosporine.	Staurosporine	135-148	myosin light chain 1	Sus scrofa	60-63
2137493-12	1990	Significantly, in the absence of PMA, staurosporine enhanced the rise in [Ca2+]i triggered by L10, suggesting that engagement of CD43 by activating ligands results in feedback inhibition by PKC.	Staurosporine	38-51	sialophorin	Homo sapiens	129-133
2137493-11	1990	Staurosporine, a potent inhibitor of PKC, abrogated the hyperphosphorylation of CD43 and normalized CD43-mediated signaling in PMA-treated cells.	Staurosporine	0-13	sialophorin	Homo sapiens	80-84
2137493-11	1990	Staurosporine, a potent inhibitor of PKC, abrogated the hyperphosphorylation of CD43 and normalized CD43-mediated signaling in PMA-treated cells.	Staurosporine	0-13	sialophorin	Homo sapiens	100-104
2137493-12	1990	Significantly, in the absence of PMA, staurosporine enhanced the rise in [Ca2+]i triggered by L10, suggesting that engagement of CD43 by activating ligands results in feedback inhibition by PKC.	Staurosporine	38-51	ribosomal protein L10	Homo sapiens	94-97
2306629-7	1990	Protein kinase inhibitors, such as staurosporine or H-7, inhibited the effects of both CSF-1 and TPA.	Staurosporine	35-48	colony stimulating factor 1 (macrophage)	Mus musculus	87-92
1688732-0	1990	Regulation of the epidermal growth factor receptor by growth-modulating agents: effects of staurosporine, a protein kinase inhibitor.	Staurosporine	91-104	epidermal growth factor receptor	Homo sapiens	18-50
1688732-2	1990	We have used staurosporine to investigate the role of phosphorylation in the regulation of the epidermal growth factor (EGF) receptor in both human epidermal carcinoma A431 cells and mouse Swiss 3T3 fibroblasts.	Staurosporine	13-26	epidermal growth factor receptor	Homo sapiens	95-133
1688732-4	1990	Staurosporine also antagonizes the inhibition of high affinity EGF binding and the increase in phosphorylation state of the unstimulated EGF receptor by phorbol esters and the calcium ionophore A23187.	Staurosporine	0-13	epidermal growth factor receptor	Homo sapiens	137-149
2297791-6	1990	Staurosporine, a potent inhibitor of PKC in vitro, inhibited Tac expression marginally in YT cells stimulated with FK, and enhanced Tac expression in cultures treated with TPA, TNF alpha, or IL-1.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	177-186
2297791-6	1990	Staurosporine, a potent inhibitor of PKC in vitro, inhibited Tac expression marginally in YT cells stimulated with FK, and enhanced Tac expression in cultures treated with TPA, TNF alpha, or IL-1.	Staurosporine	0-13	interleukin 1 alpha	Homo sapiens	191-195
7669726-4	1995	Treatment with TPA plus staurosporine, a potent protein kinase C inhibitor, results in greater expression of ctsl mRNA than does treatment with TPA alone.	Staurosporine	24-37	cathepsin L	Homo sapiens	109-113
2227125-5	1990	The importance of insulin-induced increases in DAG-PKC signaling in the stimulation of glucose transport in rat diaphragm and soleus muscles was suggested by 1) PKC activators phorbol esters and phospholipase C stimulation of [3H]-2-deoxyglucose (DOG) uptake and 2) PKC inhibitors staurosporine and polymixin B inhibition of insulin effects on [3H]-2-DOG uptake.	Staurosporine	281-294	insulin	Canis lupus familiaris	18-25
2105252-4	1990	Staurosporin, an inhibitor of protein kinase C, strongly inhibited PMA-induced PEt formation, but actually stimulated the formation of PEt in response to fMLP by several-fold.	Staurosporine	0-12	formyl peptide receptor 1	Homo sapiens	154-158
2153113-6	1990	The 3-phosphomonoesterase may be regulated by a protein kinase C, since both thrombin and phorbol dibutyrate increase 3-phosphomonoesterase activity and this is inhibited by staurosporine.	Staurosporine	174-187	coagulation factor II, thrombin	Homo sapiens	77-85
2282373-3	1990	These effects of angiotensin II were reversed when tissues were pretreated with staurosporine (50 nM), an inhibitor of protein kinase C. The amplification of the alpha-adrenoceptor-mediated vasoconstrictor effects of thrombin and norepinephrine by angiotensin II were also reversed by pretreatment with staurosporine.	Staurosporine	80-93	prothrombin	Oryctolagus cuniculus	217-225
2282373-3	1990	These effects of angiotensin II were reversed when tissues were pretreated with staurosporine (50 nM), an inhibitor of protein kinase C. The amplification of the alpha-adrenoceptor-mediated vasoconstrictor effects of thrombin and norepinephrine by angiotensin II were also reversed by pretreatment with staurosporine.	Staurosporine	303-316	prothrombin	Oryctolagus cuniculus	217-225
2144764-10	1990	The ATP requirement for p36 action was not due to a requirement for phosphorylation by protein kinase C (PKC), since the PKC inhibitor staurosporine partially inhibited endogenous secretion but did not affect the stimulation of exocytosis due to exogenous p36.	Staurosporine	135-148	annexin A2	Homo sapiens	24-27
2144764-10	1990	The ATP requirement for p36 action was not due to a requirement for phosphorylation by protein kinase C (PKC), since the PKC inhibitor staurosporine partially inhibited endogenous secretion but did not affect the stimulation of exocytosis due to exogenous p36.	Staurosporine	135-148	proline rich transmembrane protein 2	Homo sapiens	121-124
2152869-8	1990	Pretreatment with PTH, however, in the presence of H-7 or Staurosporine resulted in a completely normal cAMP response to restimulation with PTH.	Staurosporine	58-71	parathyroid hormone	Rattus norvegicus	18-21
2152869-8	1990	Pretreatment with PTH, however, in the presence of H-7 or Staurosporine resulted in a completely normal cAMP response to restimulation with PTH.	Staurosporine	58-71	parathyroid hormone	Rattus norvegicus	140-143
2294021-4	1990	Furthermore, staurosporine, a potent protein kinase inhibitor, showed strong antiproliferative activity against basic fibroblast growth factor-induced endothelial cell growth.	Staurosporine	13-26	fibroblast growth factor 2	Bos taurus	112-142
2294021-5	1990	Similarly, the chemotaxis effect of basic fibroblast growth factor on capillary endothelial cells was abolished by down-regulation of protein kinase C or by staurosporine treatment.	Staurosporine	157-170	fibroblast growth factor 2	Bos taurus	36-66
1964589-5	1990	The effect of PDB was dose-dependent and inhibited by the inhibitors of protein kinase C (PKC), staurosporine, and K252a, suggesting the involvement of PKC in the control of IL-2 mRNA stability.	Staurosporine	96-109	interleukin 2	Homo sapiens	174-178
2105370-0	1990	Inhibition by staurosporine of TRH-induced refractoriness of inositol phospholipid hydrolysis in rat anterior pituitaries.	Staurosporine	14-27	thyrotropin releasing hormone	Rattus norvegicus	31-34
2105370-1	1990	To clarify the mechanism(s) underlying the TRH-induced refractory state of the anterior pituitary, we evaluated rat pituitary inositol phospholipid hydrolysis in the presence of staurosporine.	Staurosporine	178-191	thyrotropin releasing hormone	Rattus norvegicus	43-46
2105370-5	1990	Refractoriness of inositol phospholipid hydrolysis which was produced by pretreatment with TRH and phorbol ester was inhibited by staurosporine.	Staurosporine	130-143	thyrotropin releasing hormone	Rattus norvegicus	91-94
2140592-0	1990	Inhibition of TPA-induced monocytic differentiation in THP-1 human monocytic leukemic cells by staurosporine, a potent protein kinase C inhibitor.	Staurosporine	95-108	GLI family zinc finger 2	Homo sapiens	55-60
2140592-5	1990	The inducing activity associated with TPA was completely abrogated when THP-1 cells were pretreated with staurosporine, a potent protein kinase C (PK-C) inhibitor.	Staurosporine	105-118	GLI family zinc finger 2	Homo sapiens	72-77
2210911-11	1990	Bryo 1 or PMA mediated expression of surface IL-2R and T-cell proliferation induced by bryo 1 or PMA were sensitive to inhibition by the PK-C antagonists staurosporine (Sts) and H-7.	Staurosporine	154-167	interleukin 2 receptor subunit alpha	Homo sapiens	45-50
2210911-11	1990	Bryo 1 or PMA mediated expression of surface IL-2R and T-cell proliferation induced by bryo 1 or PMA were sensitive to inhibition by the PK-C antagonists staurosporine (Sts) and H-7.	Staurosporine	169-172	interleukin 2 receptor subunit alpha	Homo sapiens	45-50
33803239-6	2021	Additionally, apelin inhibited caspase 3 and 7 activity and DNA fragmentation in staurosporine-induced apoptosis as also attenuated oxidative stress by increasing extracellular oxygen consumption.	Staurosporine	81-94	apelin	Homo sapiens	14-20
28386352-4	2017	In cultured seminiferous tubules, we found that secretion of CLU protein is upregulated by transforming growth factor-betas (TGF-beta1-3) and observed inhibition of staurosporine-induced apoptosis by recombinant CLU.	Staurosporine	165-178	clusterin	Rattus norvegicus	61-64
28386352-4	2017	In cultured seminiferous tubules, we found that secretion of CLU protein is upregulated by transforming growth factor-betas (TGF-beta1-3) and observed inhibition of staurosporine-induced apoptosis by recombinant CLU.	Staurosporine	165-178	clusterin	Rattus norvegicus	212-215
18178579-5	2008	In addition, wild-type PABPN1 provides some protection to cells against pro-apoptotic insults distinct from the OPMD mutation such as staurosporine treatment and Bax expression.	Staurosporine	134-147	poly(A) binding protein, nuclear 1	Mus musculus	23-29
7669726-5	1995	Similar to TPA, staurosporine alone increases ctsl transcription, an effect that is inhibited by cycloheximide.	Staurosporine	16-29	cathepsin L	Homo sapiens	46-50
7669726-7	1995	Staurosporine and H7, however, inhibit the increase in c-jun mRNA by TPA.	Staurosporine	0-13	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
7669726-8	1995	In contrast, the tyrosine kinase inhibitors herbimycin A and genistein inhibit the effect of TPA and staurosporine upon ctsl mRNA with little or no effect on c-jun expression.	Staurosporine	101-114	cathepsin L	Homo sapiens	120-124
7669726-9	1995	Pretreatment with sodium orthovanadate enhances the induction of ctsl expression by TPA and staurosporine.	Staurosporine	92-105	cathepsin L	Homo sapiens	65-69
34832959-5	2021	The findings disclosed that hybrid 4b displayed IC50 = 0.063 microM on the target EGFR enzyme which is slightly less potent than the standard Staurosporine (IC50 = 0.044 microM).	Staurosporine	142-155	epidermal growth factor receptor	Homo sapiens	82-86
10514480-7	1999	Endocytosis of fluorescent PTH agonist-hPTH1-Rc complexes was blocked by the protein kinase C (PKC) inhibitor staurosporine but not by the specific protein kinase A inhibitor N-(2-(methylamino)ethyl)-5-isoquinoline-sulfonamide.	Staurosporine	110-123	parathyroid hormone	Homo sapiens	27-30
34878630-6	2022	The treatment with 1 microM of staurosporine caused also a significant down-regulation of MEN1 and was able to restore the basal expression of TP53 only in QGP1 cells.	Staurosporine	31-44	menin 1	Homo sapiens	90-94
34878630-6	2022	The treatment with 1 microM of staurosporine caused also a significant down-regulation of MEN1 and was able to restore the basal expression of TP53 only in QGP1 cells.	Staurosporine	31-44	tumor protein p53	Homo sapiens	143-147
34878630-7	2022	Transient or permanent MEN1 inactivation caused a decrease of caspase 8 activity in BON1, HPSC2.2 cells and MEN1-/- MEFs treated with staurosporine.	Staurosporine	134-147	menin 1	Homo sapiens	23-27
34878630-7	2022	Transient or permanent MEN1 inactivation caused a decrease of caspase 8 activity in BON1, HPSC2.2 cells and MEN1-/- MEFs treated with staurosporine.	Staurosporine	134-147	caspase 8	Homo sapiens	62-71
34878630-7	2022	Transient or permanent MEN1 inactivation caused a decrease of caspase 8 activity in BON1, HPSC2.2 cells and MEN1-/- MEFs treated with staurosporine.	Staurosporine	134-147	menin 1	Homo sapiens	108-112
34878630-8	2022	Caspase 3/7 activity was suppressed after administration of staurosporine in MEN1 knocked down HPSC2.2 and MEN1-/- MEFs as well.	Staurosporine	60-73	caspase 3	Homo sapiens	0-11
34878630-8	2022	Caspase 3/7 activity was suppressed after administration of staurosporine in MEN1 knocked down HPSC2.2 and MEN1-/- MEFs as well.	Staurosporine	60-73	menin 1	Homo sapiens	77-81
34878630-8	2022	Caspase 3/7 activity was suppressed after administration of staurosporine in MEN1 knocked down HPSC2.2 and MEN1-/- MEFs as well.	Staurosporine	60-73	menin 1	Homo sapiens	107-111
34878630-10	2022	The treatment with staurosporine caused a reduction of the size of MEN1+/+ MEFs spheroids.	Staurosporine	19-32	menin 1	Homo sapiens	67-71
34771741-9	2021	Deconvoluted confocal images revealed that DFF40/CAD was almost completely excluded from the nucleus early after the staurosporine challenge.	Staurosporine	117-130	DNA fragmentation factor subunit beta	Homo sapiens	43-48
34771741-9	2021	Deconvoluted confocal images revealed that DFF40/CAD was almost completely excluded from the nucleus early after the staurosporine challenge.	Staurosporine	117-130	aconitate decarboxylase 1	Homo sapiens	49-52
34769389-8	2021	Moreover, the application of staurosporine led to a transient activation of ERK1/2 in all cell lines.	Staurosporine	29-42	mitogen-activated protein kinase 3	Homo sapiens	76-82
34597523-0	2022	Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2.	Staurosporine	0-13	apoptosis inducing factor mitochondria associated 1	Homo sapiens	34-59
34312810-5	2021	Phorbol 12-myristate 13-acetate and staurosporine, which induced cell adhesion to fibronectin surface and ERM dephosphorylation, caused a decrease in surface stiffness in KG-1 cells.	Staurosporine	36-49	fibronectin 1	Homo sapiens	82-93
34609126-8	2021	Following exposure to staurosporine, an apoptosis-inducing drug, we observed changes in the HepG2/C3A cellular morphology indicative of controlled cell death, and detected an increase in the pHe of HepG2/C3A.	Staurosporine	22-35	complement C3	Homo sapiens	98-101
34609126-8	2021	Following exposure to staurosporine, an apoptosis-inducing drug, we observed changes in the HepG2/C3A cellular morphology indicative of controlled cell death, and detected an increase in the pHe of HepG2/C3A.	Staurosporine	22-35	complement C3	Homo sapiens	204-207
34663225-9	2021	And the effects of PKC could be reversed by PKC-specific inhibitor staurosporine.	Staurosporine	67-80	proline rich transmembrane protein 2	Homo sapiens	19-22
34663225-9	2021	And the effects of PKC could be reversed by PKC-specific inhibitor staurosporine.	Staurosporine	67-80	proline rich transmembrane protein 2	Homo sapiens	44-47
34446569-6	2021	TRPM8 function was examined by Ca2+-imaging and patch-clamp recordings, revealing that treatment with staurosporine, a kinase inhibitor, augmented its cold- and menthol-evoked responses.	Staurosporine	102-115	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	0-5
34597523-1	2022	Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death.	Staurosporine	79-92	apoptosis inducing factor mitochondria associated 1	Homo sapiens	0-25
34597523-1	2022	Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death.	Staurosporine	79-92	apoptosis inducing factor mitochondria associated 1	Homo sapiens	27-30
34597523-1	2022	Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death.	Staurosporine	94-97	apoptosis inducing factor mitochondria associated 1	Homo sapiens	0-25
34597523-1	2022	Apoptosis-inducing factor (AIF) is a mitochondrial flavoprotein which mediates staurosporine (STS)-induced cell death.	Staurosporine	94-97	apoptosis inducing factor mitochondria associated 1	Homo sapiens	27-30
34597523-6	2022	A significant increase in cellular MMP-2 activity was seen by gelatin zymography after 6 hr STS treatment, prior to induction of cell necrosis.	Staurosporine	92-95	matrix metallopeptidase 2	Homo sapiens	35-40
35626686-5	2022	With human dopaminergic neurons derived from induced pluripotent stem cells, STIP1 was found to alleviate staurosporine-induced neurotoxicity.	Staurosporine	106-119	stress induced phosphoprotein 1	Homo sapiens	77-82
34539620-11	2021	In contrast, staurosporine treatment resulted in increased NO production, as well as arginase-1 activity.	Staurosporine	13-26	arginase 1	Rattus norvegicus	85-95
34299239-6	2021	Results from this study revealed that the presence of estrogen receptor beta in mitochondria render N2A cells more resistant to staurosporine- and H2O2-induced apoptotic stimuli, as indicated by the reduced activation of caspase-9 and -3, the increased cell viability, the increased ATP production, and the increased resistance to mitochondrial impairment in the presence or absence of 17-beta estradiol (E2).	Staurosporine	128-141	estrogen receptor 1 (alpha)	Mus musculus	54-76
34299239-6	2021	Results from this study revealed that the presence of estrogen receptor beta in mitochondria render N2A cells more resistant to staurosporine- and H2O2-induced apoptotic stimuli, as indicated by the reduced activation of caspase-9 and -3, the increased cell viability, the increased ATP production, and the increased resistance to mitochondrial impairment in the presence or absence of 17-beta estradiol (E2).	Staurosporine	128-141	caspase 9	Mus musculus	221-237
34154403-7	2021	We discovered that albumin, similarly, can neutralize a variety of fungal (alpha-amanitin), bacterial (streptolysin O and staurosporin), and insect (melittin) hydrophobic toxins.	Staurosporine	122-134	albumin	Homo sapiens	19-26
34376637-6	2021	We developed a mCherry-BCLXL fusion protein, which prevented BAX recruitment and activation to the mitochondria in tissue culture cells exposed to staurosporine.	Staurosporine	147-160	BCL2-like 1	Mus musculus	23-28
34376637-6	2021	We developed a mCherry-BCLXL fusion protein, which prevented BAX recruitment and activation to the mitochondria in tissue culture cells exposed to staurosporine.	Staurosporine	147-160	BCL2-associated X protein	Mus musculus	61-64
34290285-7	2021	Pharmacological intervention with the apoptosis inducer staurosporine and mutation in a secondary gene (CYLD) also induced measurable cytoplasmic mislocalisation of endogenous FUS and TDP-43, respectively.	Staurosporine	56-69	FUS RNA binding protein	Homo sapiens	176-179
34290285-7	2021	Pharmacological intervention with the apoptosis inducer staurosporine and mutation in a secondary gene (CYLD) also induced measurable cytoplasmic mislocalisation of endogenous FUS and TDP-43, respectively.	Staurosporine	56-69	TAR DNA binding protein	Homo sapiens	184-190
35545041-6	2022	SETD4 knockdown enhances staurosporine (STS)-induced apoptosis and cell killing.	Staurosporine	25-38	SET domain containing 4	Homo sapiens	0-5
35545041-6	2022	SETD4 knockdown enhances staurosporine (STS)-induced apoptosis and cell killing.	Staurosporine	40-43	SET domain containing 4	Homo sapiens	0-5
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Staurosporine	189-202	dynamin 1 like	Homo sapiens	27-31
35460011-5	2022	We demonstrated that DFF40-deficient cells are more resistant to staurosporine and tributyltin (TBT)-induced apoptosis, and express higher levels of Mcl-1 at basal state.	Staurosporine	65-78	DNA fragmentation factor subunit beta	Homo sapiens	21-26
35514983-4	2022	We found that microglia release nanomolar levels of calreticulin when inflammatory-activated with lipopolysaccharide, when endoplasmic reticulum stress was induced by tunicamycin, or when cell death was induced by staurosporine, and that neurons release calreticulin when crushed.	Staurosporine	214-227	calreticulin	Homo sapiens	52-64
35112472-6	2022	The KLHL38 overexpression obviously promoted cardiomyocyte apoptosis treated with staurosporine (STS) by facilitation of myocardin"s ubiquitylation and subsequent proteasomal degradation.	Staurosporine	82-95	kelch-like 38	Mus musculus	4-10
35112472-6	2022	The KLHL38 overexpression obviously promoted cardiomyocyte apoptosis treated with staurosporine (STS) by facilitation of myocardin"s ubiquitylation and subsequent proteasomal degradation.	Staurosporine	82-95	myocardin	Homo sapiens	121-130
35112472-6	2022	The KLHL38 overexpression obviously promoted cardiomyocyte apoptosis treated with staurosporine (STS) by facilitation of myocardin"s ubiquitylation and subsequent proteasomal degradation.	Staurosporine	97-100	kelch-like 38	Mus musculus	4-10
35112472-6	2022	The KLHL38 overexpression obviously promoted cardiomyocyte apoptosis treated with staurosporine (STS) by facilitation of myocardin"s ubiquitylation and subsequent proteasomal degradation.	Staurosporine	97-100	myocardin	Homo sapiens	121-130
35158046-8	2022	Accordingly, inhibition of DRP1 activity with its pharmacological inhibitor or siDRP1 efficiently attenuated ethanol- or acetaldehyde-induced apoptosis, whereas activation of DRP1 by using staurosporine (STS) further increased apoptosis in ethanol- or acetaldehyde-treated HepG2 or HL7702 cells.	Staurosporine	189-202	dynamin 1 like	Homo sapiens	175-179
35296739-7	2022	An increase in the proportion of bound NADPH was detected only in staurosporine-treated cells, this likely being associated with a high level of ROS production and their resulting detoxification.	Staurosporine	66-79	2,4-dienoyl-CoA reductase 1	Homo sapiens	39-44
35159330-10	2022	In the next step, FGF1 variants with mutated or deleted NLS were expressed in U2OS cells, in which apoptosis was then induced by various factors (e.g., starvation, etoposide, staurosporine, anisomycin and actinomycin D).	Staurosporine	175-188	fibroblast growth factor 1	Homo sapiens	18-22
35203326-0	2022	PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage.	Staurosporine	23-36	PTEN induced kinase 1	Homo sapiens	0-5
35203326-0	2022	PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage.	Staurosporine	23-36	beclin 1	Homo sapiens	75-82
35203326-5	2022	To do so, we used SH-SY5Y neuroblastoma cells, a neuronal model used in Parkinson"s disease and cancer studies, to characterize the pro-survival functions of PINK1 in response to the apoptosis inducer staurosporine.	Staurosporine	201-214	PTEN induced kinase 1	Homo sapiens	158-163
35203326-6	2022	In this setting, we found that staurosporine induces apoptosis but not mitophagy, and we demonstrated that PINK1 protects against staurosporine-induced apoptosis by impairing the pro-apoptotic cleavage of Beclin1.	Staurosporine	31-44	PTEN induced kinase 1	Homo sapiens	107-112
35203326-6	2022	In this setting, we found that staurosporine induces apoptosis but not mitophagy, and we demonstrated that PINK1 protects against staurosporine-induced apoptosis by impairing the pro-apoptotic cleavage of Beclin1.	Staurosporine	130-143	PTEN induced kinase 1	Homo sapiens	107-112
35203326-7	2022	Our data also show that staurosporine-induced apoptosis is preceded by a phase of enhanced autophagy, and that PINK1 in this context regulates the switch from autophagy to apoptosis.	Staurosporine	24-37	PTEN induced kinase 1	Homo sapiens	111-116
35186954-5	2021	Drug-induced apoptosis was analyzed after exposure to staurosporine by caspase 3/7 activity and by annexin-V/7-actinomycin D (7-AAD) staining, followed by flow cytometry.	Staurosporine	54-67	caspase 3	Homo sapiens	71-82
35186954-12	2021	NPPB and NFA also suppressed staurosporine-induced caspase 3/7 activation, while DCPIB and Tamoxifen showed cytotoxic effects per se.	Staurosporine	29-42	caspase 3	Homo sapiens	51-62
2690823-6	1989	Insulin secretion induced by TPA was completely suppressed (IC50 approximately 10 nM) by staurosporine, a potent protein kinase C inhibitor.	Staurosporine	89-102	insulin	Homo sapiens	0-7
34939697-3	2022	Now using genetically encoded Ca2+ indicators complemented with automated epifluorescence microscopy we have shown that staurosporine-induced apoptosis in MDA-MB-231 breast cancer cells was associated with delayed development of cytosolic free Ca2+ fluctuations, which were then maintained for 24 h. These cytosolic free Ca2+ fluctuations were dependent on the Ca2+ channel ORAI1.	Staurosporine	120-133	ORAI calcium release-activated calcium modulator 1	Homo sapiens	374-379
2610702-4	1989	The efficacy of the inhibitors in vivo was shown by their ability to suppress PKC-induced transcription of c-fos gen. PKC inhibitors that interfered with cell proliferation at lower concentrations than those required for PKC inhibition (sphingosine, staurosporin, sangivamycin, trifluoperazine) did not stimulate anchorage-independent growth.	Staurosporine	250-262	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
2559721-2	1989	Staurosporine prevented the enhanced protein phosphorylation in phorbol ester- and N-formylmethyionyl-leucylphenylalanine (fMLP)-stimulated cells, and was a powerful inhibitor of the respiratory burst induced by phorbol myristate acetate [IC50 (concentration causing 50% inhibition) 17 nM] and the chemotactic peptides fMLP and C5a (IC50 24 nM).	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	83-121
2559721-2	1989	Staurosporine prevented the enhanced protein phosphorylation in phorbol ester- and N-formylmethyionyl-leucylphenylalanine (fMLP)-stimulated cells, and was a powerful inhibitor of the respiratory burst induced by phorbol myristate acetate [IC50 (concentration causing 50% inhibition) 17 nM] and the chemotactic peptides fMLP and C5a (IC50 24 nM).	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	123-127
2559721-2	1989	Staurosporine prevented the enhanced protein phosphorylation in phorbol ester- and N-formylmethyionyl-leucylphenylalanine (fMLP)-stimulated cells, and was a powerful inhibitor of the respiratory burst induced by phorbol myristate acetate [IC50 (concentration causing 50% inhibition) 17 nM] and the chemotactic peptides fMLP and C5a (IC50 24 nM).	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	319-323
2559721-2	1989	Staurosporine prevented the enhanced protein phosphorylation in phorbol ester- and N-formylmethyionyl-leucylphenylalanine (fMLP)-stimulated cells, and was a powerful inhibitor of the respiratory burst induced by phorbol myristate acetate [IC50 (concentration causing 50% inhibition) 17 nM] and the chemotactic peptides fMLP and C5a (IC50 24 nM).	Staurosporine	0-13	complement C5a receptor 1	Homo sapiens	328-331
2553861-1	1989	Staurosporine, which has a structure similar to that of K-252a, a potent protein kinase inhibitor that blocks nerve growth factor (NGF) action in PC12 and PC12h cells, is also known as a potent inhibitor of several protein kinases.	Staurosporine	0-13	nerve growth factor	Rattus norvegicus	110-129
2553861-1	1989	Staurosporine, which has a structure similar to that of K-252a, a potent protein kinase inhibitor that blocks nerve growth factor (NGF) action in PC12 and PC12h cells, is also known as a potent inhibitor of several protein kinases.	Staurosporine	0-13	nerve growth factor	Rattus norvegicus	131-134
2553861-2	1989	This study shows that in PC12h cells staurosporine has a dual action: at lower concentrations than that required by K-252a, it is an inhibitor of NGF induction of neurite formation and of changes in the phosphorylation of specific proteins, whereas at concentrations higher than that required to inhibit NGF-induced neurite outgrowth, it rapidly enhances outgrowth by itself.	Staurosporine	37-50	nerve growth factor	Rattus norvegicus	146-149
2553861-2	1989	This study shows that in PC12h cells staurosporine has a dual action: at lower concentrations than that required by K-252a, it is an inhibitor of NGF induction of neurite formation and of changes in the phosphorylation of specific proteins, whereas at concentrations higher than that required to inhibit NGF-induced neurite outgrowth, it rapidly enhances outgrowth by itself.	Staurosporine	37-50	nerve growth factor	Rattus norvegicus	304-307
2698938-5	1989	Vasoconstriction and inhibition of renin release by endothelin are attenuated in the presence of a protein kinase C inhibitor, staurosporine, which suggests that protein kinase C helps to mediate the effects of endothelin on renin secretion and vascular resistance.	Staurosporine	127-140	renin	Rattus norvegicus	35-40
2698938-5	1989	Vasoconstriction and inhibition of renin release by endothelin are attenuated in the presence of a protein kinase C inhibitor, staurosporine, which suggests that protein kinase C helps to mediate the effects of endothelin on renin secretion and vascular resistance.	Staurosporine	127-140	renin	Rattus norvegicus	225-230
2583867-0	1989	Staurosporine stimulates expression of the urokinase-type (u-PA) plasminogen activator in LLC-PK1 cells.	Staurosporine	0-13	plasminogen activator, urokinase	Sus scrofa	43-63
2690823-8	1989	In addition, staurosporine partially (approximately 60%) inhibited glucose-induced insulin secretion at concentrations (IC50 approximately 10 nM) similar to those required to inhibit TPA-induced insulin secretion, suggesting that staurosporine may act at a step common to both mechanisms, possibly the activation of protein kinase C. However, stimulatory concentrations of glucose did not induce down-regulation of translocation of protein kinase C, and the inhibition of glucose-induced insulin release by staurosporine was incomplete.	Staurosporine	13-26	insulin	Homo sapiens	83-90
2808540-6	1989	We have determined whether IL2 secretion can be induced in the murine cell T-lymphocyte line LBRM 331A5, where PKC is inhibited by staurosporine or sphingosine or in cells where PKC is depleted by prolonged incubation with high concentrations of phorbol esters.	Staurosporine	131-144	interleukin 2	Mus musculus	27-30
2510716-7	1989	That secretion induced by these agents is a protein kinase C-dependent event was demonstrable by using staurosporine, a protein kinase C inhibitor which at concentrations of 1-10 nM inhibited (70-90%) PMA-induced as well as thrombin- and NaF-induced secretion and protein phosphorylation.	Staurosporine	103-116	coagulation factor II, thrombin	Homo sapiens	224-232
2615195-8	1989	Phorbol ester (PMA) also stimulated elastase release but both PTH or PMA-induced elastase release was blunted by staurosporin, an inhibitor of protein kinase C. The 19-84 carboxyterminal PTH also produced significant stimulation of elastase release from PMNL but the amino-terminal 1-34 PTH or other peptide hormones (insulin, calcitonin, and ACTH) had no stimulatory effect on elastase release.	Staurosporine	113-125	proopiomelanocortin	Homo sapiens	343-347
2506174-11	1989	H-7 and staurosporine also inhibited the PMA/forskolin-induced increase in tPA mRNA levels and were less effective the later they were added.	Staurosporine	8-21	chromosome 20 open reading frame 181	Homo sapiens	75-78
2552043-5	1989	Down-regulation of PKC by prolonged treatment with phorbol esters and treatment of the cells with staurosporine, which inhibits PKC, blocked both bradykinin- and phorbol ester-induced 45Ca influx, and substantially reduced the proportion of cells that gave electrophysiological responses to either agent.	Staurosporine	98-111	protein kinase C, gamma	Rattus norvegicus	19-22
2552043-5	1989	Down-regulation of PKC by prolonged treatment with phorbol esters and treatment of the cells with staurosporine, which inhibits PKC, blocked both bradykinin- and phorbol ester-induced 45Ca influx, and substantially reduced the proportion of cells that gave electrophysiological responses to either agent.	Staurosporine	98-111	protein kinase C, gamma	Rattus norvegicus	128-131
2553861-0	1989	Blockage of nerve growth factor action in PC12h cells by staurosporine, a potent protein kinase inhibitor.	Staurosporine	57-70	nerve growth factor	Rattus norvegicus	12-31
2570702-2	1989	Staurosporine has been reported to be a specific inhibitor of protein kinase C. However, we show that it inhibits the Ca2+ influx in anti-CD3 and phytohemagglutinin-stimulated human CD4+ and CD8+ lymphocytes at concentrations between 1.0 and 10.0 ng/ml.	Staurosporine	0-13	CD4 molecule	Homo sapiens	182-185
2570702-2	1989	Staurosporine has been reported to be a specific inhibitor of protein kinase C. However, we show that it inhibits the Ca2+ influx in anti-CD3 and phytohemagglutinin-stimulated human CD4+ and CD8+ lymphocytes at concentrations between 1.0 and 10.0 ng/ml.	Staurosporine	0-13	CD8a molecule	Homo sapiens	191-194
2570702-3	1989	Staurosporine decreases the number of Ca2+-positive CD4+ and CD8+ lymphocytes as well as the Ca2+ influx per cell; the drug also delays the time of the maximum response to polyclonal stimulation.	Staurosporine	0-13	CD4 molecule	Homo sapiens	52-55
2570702-3	1989	Staurosporine decreases the number of Ca2+-positive CD4+ and CD8+ lymphocytes as well as the Ca2+ influx per cell; the drug also delays the time of the maximum response to polyclonal stimulation.	Staurosporine	0-13	CD8a molecule	Homo sapiens	61-64
2570702-4	1989	In addition, we demonstrate that staurosporine affects the primary Ca2+ response via inhibition of the release of the membrane-bound Ca2+ from the endoplasmic reticulum in CD4+ and CD8+ lymphocytes.	Staurosporine	33-46	CD4 molecule	Homo sapiens	172-175
2570702-4	1989	In addition, we demonstrate that staurosporine affects the primary Ca2+ response via inhibition of the release of the membrane-bound Ca2+ from the endoplasmic reticulum in CD4+ and CD8+ lymphocytes.	Staurosporine	33-46	CD8a molecule	Homo sapiens	181-184
2673889-3	1989	Insulin- and PMA-stimulated 2-deoxyglucose transport were both markedly inhibited by sphingosine (5-50 microM) and staurosporine (0.1-2 microM), although with differences in the extents of maximal inhibitions (65 and 48% vs. 88 and 98%) and the concentrations of the drugs causing the half-maximal inhibitions observed in the experiments (2- to 3-fold higher for insulin).	Staurosporine	115-128	insulin	Homo sapiens	0-7
2673889-3	1989	Insulin- and PMA-stimulated 2-deoxyglucose transport were both markedly inhibited by sphingosine (5-50 microM) and staurosporine (0.1-2 microM), although with differences in the extents of maximal inhibitions (65 and 48% vs. 88 and 98%) and the concentrations of the drugs causing the half-maximal inhibitions observed in the experiments (2- to 3-fold higher for insulin).	Staurosporine	115-128	insulin	Homo sapiens	363-370
2544313-0	1989	Differential inhibition by staurosporine, a potent protein kinase C inhibitor, of 12-O-tetradecanoylphorbol-13-acetate-caused skin tumor promotion, epidermal ornithine decarboxylase induction, hyperplasia and inflammation.	Staurosporine	27-40	ornithine decarboxylase, structural 1	Mus musculus	158-181
2742593-6	1989	The PKC inhibitors staurosporine and H-7 prevented both PMA and Mezerein-induced stimulation of HUVEC expression of ICAM 1 and adherence for PMN.	Staurosporine	19-32	intercellular adhesion molecule 1	Homo sapiens	116-122
2801336-4	1989	Sphingosine and staurosporin, inhibitors of PKC, each eliminated the synergistic effect of PMA upon enzyme induction by high doses (10 U/ml) of IL-1, but failed to influence enzyme induction by this dose of IL-1 alone.	Staurosporine	16-28	proline rich transmembrane protein 2	Homo sapiens	44-47
2801336-4	1989	Sphingosine and staurosporin, inhibitors of PKC, each eliminated the synergistic effect of PMA upon enzyme induction by high doses (10 U/ml) of IL-1, but failed to influence enzyme induction by this dose of IL-1 alone.	Staurosporine	16-28	interleukin 1 alpha	Homo sapiens	144-148
2498530-10	1989	The secretion of IFN induced by these agents in PM and by LPS in RAW 264.7 cells and the corresponding accumulation of IFN-beta mRNA are blocked by an inhibitor of protein kinase C, staurosporine.	Staurosporine	182-195	toll-like receptor 4	Mus musculus	58-61
2498530-10	1989	The secretion of IFN induced by these agents in PM and by LPS in RAW 264.7 cells and the corresponding accumulation of IFN-beta mRNA are blocked by an inhibitor of protein kinase C, staurosporine.	Staurosporine	182-195	interferon beta 1, fibroblast	Mus musculus	119-127
2497461-3	1989	Although the phosphorylation of the 70-kDa protein by isolated plasma membranes takes place in the presence of EGTA, we conclude that the reaction is catalyzed by PK-C based on its inhibition by staurosporin.	Staurosporine	195-207	protein kinase C, gamma	Rattus norvegicus	163-167
2703480-0	1989	Inhibition of protein kinase C by staurosporine promotes elevated accumulations of inositol trisphosphates and tetrakisphosphate in human platelets exposed to thrombin.	Staurosporine	34-47	coagulation factor II, thrombin	Homo sapiens	159-167
2705995-6	1989	In contrast, aggregation induced by thrombin, platelet-activating factor or ionophore A23187 is rapid (occurs within 60 s), and is slowed, but not inhibited, in the presence of staurosporine.	Staurosporine	177-190	coagulation factor II, thrombin	Homo sapiens	36-44
2705995-7	1989	On the other hand, staurosporine causes a small potentiation of the peak [Ca2+]i signal induced by thrombin and a marked increase in the half-life of decay of this signal, but has no effect on pHi.	Staurosporine	19-32	coagulation factor II, thrombin	Homo sapiens	99-107
2705995-8	1989	Under conditions designed to prevent an increase in [Ca2+]i (presence of Ni2+ to prevent Ca2+ entry, and depletion of the intracellular Ca2+ stores), aggregation induced by thrombin resembles that by phorbol dibutyrate and is now inhibited completely by staurosporine.	Staurosporine	254-267	coagulation factor II, thrombin	Homo sapiens	173-181
2705995-9	1989	Taken together, these results provide evidence for two signalling pathways for aggregation, a relatively rapid phosphorylation-independent route mediated by Ca2+ and a slower, phosphorylation-dependent, pathway mediated by protein kinase C. Since staurosporine slows aggregation induced by thrombin, it appears that under normal conditions these pathways interact synergistically.	Staurosporine	247-260	coagulation factor II, thrombin	Homo sapiens	290-298
2546764-6	1989	Staurosporine, an inhibitor of protein kinase C, blocks PAF production apparently by inhibiting phospholipase A2.	Staurosporine	0-13	PCNA clamp associated factor	Homo sapiens	56-59
2546764-6	1989	Staurosporine, an inhibitor of protein kinase C, blocks PAF production apparently by inhibiting phospholipase A2.	Staurosporine	0-13	phospholipase A2 group IB	Homo sapiens	96-112
2510716-7	1989	That secretion induced by these agents is a protein kinase C-dependent event was demonstrable by using staurosporine, a protein kinase C inhibitor which at concentrations of 1-10 nM inhibited (70-90%) PMA-induced as well as thrombin- and NaF-induced secretion and protein phosphorylation.	Staurosporine	103-116	C-X-C motif chemokine ligand 8	Homo sapiens	238-241
2563920-5	1989	Moreover, EGTA and a direct (staurosporine) or a competitive (1-[5-isoquinolinylsulfonyl]-2-methyl piperazine) inhibitor of protein kinase C prevents T cell proliferation accomplished with crosslinked anti-TCR-1 and OKT11.	Staurosporine	29-42	sperm motility kinase 1	Mus musculus	206-211
2465187-5	1989	The ability of staurosporine to block the mRNA responses of either EGF or TPA suggests that these two agents have common signaling pathways and it implies a role for protein kinase C in the control of EGF receptor and TGF-alpha expression.	Staurosporine	15-28	transforming growth factor alpha	Homo sapiens	218-227
2534962-3	1989	The manner of this inhibitory action by staurosporine was similar to that of various kinds of antitumor-promoting agents, which have the ability to interact with Ca2(+)-calmodulin complex, although the effective dose of staurosporine was 1,000 times lower than these calmodulin-interacting agents.	Staurosporine	40-53	calmodulin 1	Homo sapiens	169-179
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 2	Homo sapiens	98-123
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 2	Homo sapiens	125-128
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	interleukin 3	Homo sapiens	131-144
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	interleukin 3	Homo sapiens	146-150
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 2	Homo sapiens	153-179
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 2	Homo sapiens	181-187
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 2	Homo sapiens	176-179
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 3	Homo sapiens	207-212
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 2	Homo sapiens	176-179
2783371-3	1989	The presence of H-7 or staurosporine led to an inhibition of colony formation stimulated by crude colony-stimulating factor (CSF), interleukin-3 (IL-3), granulocyte-macrophage CSF (GM-CSF), granulocyte CSF (G-CSF), or macrophage CSF (M-CSF) in a dose-dependent manner.	Staurosporine	23-36	colony stimulating factor 1	Homo sapiens	182-187
2534962-3	1989	The manner of this inhibitory action by staurosporine was similar to that of various kinds of antitumor-promoting agents, which have the ability to interact with Ca2(+)-calmodulin complex, although the effective dose of staurosporine was 1,000 times lower than these calmodulin-interacting agents.	Staurosporine	40-53	calmodulin 1	Homo sapiens	267-277
2534962-3	1989	The manner of this inhibitory action by staurosporine was similar to that of various kinds of antitumor-promoting agents, which have the ability to interact with Ca2(+)-calmodulin complex, although the effective dose of staurosporine was 1,000 times lower than these calmodulin-interacting agents.	Staurosporine	220-233	calmodulin 1	Homo sapiens	169-179
2534962-3	1989	The manner of this inhibitory action by staurosporine was similar to that of various kinds of antitumor-promoting agents, which have the ability to interact with Ca2(+)-calmodulin complex, although the effective dose of staurosporine was 1,000 times lower than these calmodulin-interacting agents.	Staurosporine	220-233	calmodulin 1	Homo sapiens	267-277
2534962-4	1989	Furthermore, staurosporine was proved to interact directly with Ca2(+)-calmodulin complex.	Staurosporine	13-26	calmodulin 1	Homo sapiens	71-81
2534962-5	1989	Thus, it is possible that staurosporine showed inhibitory effect on phospholipid metabolism via the modulation of Ca2(+)-calmodulin system.	Staurosporine	26-39	calmodulin 1	Homo sapiens	121-131
2621325-0	1989	Potent inhibition of interleukin 1 beta-mediated human melanoma (A375.6) lysis by corticosteroids, staurosporine, and tilorone.	Staurosporine	99-112	interleukin 1 beta	Homo sapiens	21-39
2761290-6	1989	In the presence of the protein kinase inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7, 20 microM) and staurosporine (10 nM), the increase in actin levels induced by TPA was inhibited as well as other later evidence of differentiation.	Staurosporine	133-146	plasminogen activator, tissue type	Homo sapiens	196-199
2761347-0	1989	Staurosporine potentiates platelet activating factor stimulated phospholipase C activity in rabbit platelets but does not block desensitization by platelet activating factor.	Staurosporine	0-13	LOC100009319	Oryctolagus cuniculus	64-79
2974700-1	1988	Staurosporine is a 100-times more potent inhibitor of insulin receptor than IGF-I receptor.	Staurosporine	0-13	insulin	Homo sapiens	54-61
2974700-11	1988	Staurosporine is thus an excellent tool to biochemically characterize the two receptor TPKs as well as to selectively inhibit insulin-activated TPK in intact cells.	Staurosporine	0-13	insulin	Homo sapiens	126-133
3196353-0	1988	Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. We found that staurosporine, a potent inhibitor of protein kinase C, inhibits induction of ornithine decarboxylase (ODC) and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mouse skin.	Staurosporine	109-122	ornithine decarboxylase, structural 1	Mus musculus	48-71
3196353-0	1988	Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. We found that staurosporine, a potent inhibitor of protein kinase C, inhibits induction of ornithine decarboxylase (ODC) and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mouse skin.	Staurosporine	109-122	ornithine decarboxylase, structural 1	Mus musculus	255-278
3196353-0	1988	Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. We found that staurosporine, a potent inhibitor of protein kinase C, inhibits induction of ornithine decarboxylase (ODC) and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mouse skin.	Staurosporine	109-122	ornithine decarboxylase, structural 1	Mus musculus	280-283
3196353-0	1988	Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. We found that staurosporine, a potent inhibitor of protein kinase C, inhibits induction of ornithine decarboxylase (ODC) and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mouse skin.	Staurosporine	178-191	ornithine decarboxylase, structural 1	Mus musculus	48-71
3196353-0	1988	Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. We found that staurosporine, a potent inhibitor of protein kinase C, inhibits induction of ornithine decarboxylase (ODC) and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mouse skin.	Staurosporine	178-191	ornithine decarboxylase, structural 1	Mus musculus	255-278
3196353-0	1988	Inhibition of phorbol ester-caused induction of ornithine decarboxylase and tumor promotion in mouse skin by staurosporine, a potent inhibitor of protein kinase C. We found that staurosporine, a potent inhibitor of protein kinase C, inhibits induction of ornithine decarboxylase (ODC) and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mouse skin.	Staurosporine	178-191	ornithine decarboxylase, structural 1	Mus musculus	280-283
3196353-1	1988	When applied 5 min either before or after treatment with TPA, 1 microgram of staurosporine cause about 56% inhibition of ODC-induction by 5 micrograms of TPA.	Staurosporine	77-90	ornithine decarboxylase, structural 1	Mus musculus	121-124
3190703-5	1988	Dose response curves for staurosporine-mediated inhibition of DNA synthesis were essentially parallel for insulin, EGF, FGF, PDGF and PMA; however, mitogenesis in response to serum was more resistant to staurosporine.	Staurosporine	25-38	insulin	Homo sapiens	106-113
3190703-5	1988	Dose response curves for staurosporine-mediated inhibition of DNA synthesis were essentially parallel for insulin, EGF, FGF, PDGF and PMA; however, mitogenesis in response to serum was more resistant to staurosporine.	Staurosporine	25-38	epidermal growth factor	Homo sapiens	115-118
2846820-5	1988	The protein kinase inhibitors H-7 and staurosporine blocked mezerein-, but not PHI-, induced losses of cell surface VIP-R.	Staurosporine	38-51	vasoactive intestinal peptide receptor 1	Homo sapiens	116-121
3185968-5	1988	Inactivation of protein kinase C with the inhibitor staurosporine (10-100 nM) attenuated the effect of bradykinin and PDBu but not that of capsaicin.	Staurosporine	52-65	kininogen 1	Homo sapiens	103-113
2534942-5	1989	Desensitization of protein kinase C (PKC) by prolonged exposure of the cells to PDBu or addition of the PKC inhibitor staurosporine during pretreatment with AVP did not prevent AVP-mediated desensitization, suggesting that PKC may not be involved in AVP-mediated desensitization in smooth muscle cells.	Staurosporine	118-131	proline rich transmembrane protein 2	Homo sapiens	104-107
2534942-5	1989	Desensitization of protein kinase C (PKC) by prolonged exposure of the cells to PDBu or addition of the PKC inhibitor staurosporine during pretreatment with AVP did not prevent AVP-mediated desensitization, suggesting that PKC may not be involved in AVP-mediated desensitization in smooth muscle cells.	Staurosporine	118-131	proline rich transmembrane protein 2	Homo sapiens	104-107
2471393-10	1988	However, TNF receptors decreased in peritoneal macrophages treated with staurosporine.	Staurosporine	72-85	tumor necrosis factor	Mus musculus	9-12
2471393-11	1988	This finding was explained by activation of macrophages by staurosporine, which induced secretion of TNF.	Staurosporine	59-72	tumor necrosis factor	Mus musculus	101-104
2538812-9	1989	A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol.	Staurosporine	121-133	nerve growth factor	Rattus norvegicus	24-27
2538812-9	1989	A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol.	Staurosporine	121-133	nerve growth factor	Rattus norvegicus	88-91
2538812-9	1989	A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol.	Staurosporine	121-133	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	102-107
2538812-9	1989	A possible role for the NGF-stimulated diacylglycerol is suggested by the inhibition of NGF-dependent c-fos induction by staurosporin, a potent inhibitor of protein kinase C. These results suggest that, like insulin, some of the cellular effects of NGF may be mediated by the phospholipase C-catalyzed hydrolysis of glycosylphosphatidylinositol.	Staurosporine	121-133	nerve growth factor	Rattus norvegicus	88-91
2835653-0	1988	Staurosporine inhibits protein kinase C and prevents phorbol ester-mediated leukotriene D4 receptor desensitization in RBL-1 cells.	Staurosporine	0-13	RB transcriptional corepressor like 1	Rattus norvegicus	119-124
3045817-6	1988	Studies with the calcium ionophore ionomycin, 1,2-dioctanoyl-sn-glycerol, and the protein kinase inhibitor staurosporine indicate that both protein kinase C-dependent and protein kinase C-independent (staurosporine-insensitive) mechanisms mediate heterologous desensitization after mIg crosslinking.	Staurosporine	201-214	chemokine (C-X-C motif) ligand 9	Mus musculus	282-285
2835653-9	1988	These results show that PMA-induced heterologous desensitization is mediated by PKC and staurosporine prevented this process by directly inhibiting PKC in intact RBL-1 cells.	Staurosporine	88-101	RB transcriptional corepressor like 1	Rattus norvegicus	162-167
2831891-2	1988	Platelet activation by thrombin was only slightly suppressed by polymyxin B, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7) or staurosporine, all being potent inhibitors of PKC in vitro.	Staurosporine	132-145	coagulation factor II, thrombin	Homo sapiens	23-31
3278921-6	1988	In intact ZR-75-1 cells staurosporine blocks activation of S6 kinase by EGF and TPA, however with different IC50.	Staurosporine	24-37	epidermal growth factor	Homo sapiens	72-75
3257691-4	1988	Staurosporine (1 microM) fully inhibited the phosphorylation of the 47 kDa protein in platelets challenged with thrombin, but also inhibited the phosphorylation of a 20 kDa protein which is a substrate for myosin light-chain kinase.	Staurosporine	0-13	coagulation factor II, thrombin	Homo sapiens	112-120
3257691-4	1988	Staurosporine (1 microM) fully inhibited the phosphorylation of the 47 kDa protein in platelets challenged with thrombin, but also inhibited the phosphorylation of a 20 kDa protein which is a substrate for myosin light-chain kinase.	Staurosporine	0-13	myosin light chain kinase	Homo sapiens	206-231
3257691-5	1988	The inhibition of both kinases by staurosporine was associated with the inhibition of thrombin-induced secretion of ATP and 5-hydroxytryptamine and a slowing of the aggregation response; staurosporine, however, had no effect on the formation of phosphatidic acid and inositol phosphates induced by thrombin.	Staurosporine	34-47	coagulation factor II, thrombin	Homo sapiens	86-94
3257691-5	1988	The inhibition of both kinases by staurosporine was associated with the inhibition of thrombin-induced secretion of ATP and 5-hydroxytryptamine and a slowing of the aggregation response; staurosporine, however, had no effect on the formation of phosphatidic acid and inositol phosphates induced by thrombin.	Staurosporine	34-47	coagulation factor II, thrombin	Homo sapiens	298-306
3257691-6	1988	Staurosporine also reversed the inhibitory action of phorbol esters on thrombin-induced formation of phosphatidic acid.	Staurosporine	0-13	coagulation factor II, thrombin	Homo sapiens	71-79
3133109-6	1988	Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment.	Staurosporine	58-71	alpha- and gamma-adaptin binding protein	Mus musculus	121-124
3133109-6	1988	Inhibitors of PKC, such as chlorpromazine, quercetin, and staurosporine inhibited these increases in phosphorylations of p34 and p40 on TPA treatment.	Staurosporine	58-71	interleukin 12b	Mus musculus	129-132
2830284-7	1988	The protein kinase C inhibitor, staurosporine, blocked the inhibitory effect of phorbol ester and also reduced the rate of desensitization of thrombin and subsequent epinephrine action.	Staurosporine	32-45	coagulation factor II, thrombin	Homo sapiens	142-150
2835653-2	1988	Staurosporine, one of the most potent PKC inhibitors known to date, markedly inhibited partially purified PKC from RBL-1 cells with an IC50 of 3 nM.	Staurosporine	0-13	RB transcriptional corepressor like 1	Rattus norvegicus	115-120
2835653-7	1988	Pretreatment of RBL-1 cells with staurosporine inhibited the PMA-induced activation of PKC in the membrane fraction.	Staurosporine	33-46	RB transcriptional corepressor like 1	Rattus norvegicus	16-21
3689369-3	1987	Staurosporine by itself induced ODC activity as TPA does.	Staurosporine	0-13	ornithine decarboxylase, structural 1	Mus musculus	32-35
3593358-3	1987	Several effects induced by phorbol esters and diacylglycerols, including the rise in (Ca2+)i, the stimulation of Na+/H+ transporter and the inhibition of the effects of thrombin alone on (Ca2+)i are potently antagonised by staurosporine, a compound known to inhibit protein kinase C. Higher concentrations of staurosporine themselves inhibit the thrombin-induced calcium transient.	Staurosporine	223-236	coagulation factor II, thrombin	Homo sapiens	346-354
3593358-3	1987	Several effects induced by phorbol esters and diacylglycerols, including the rise in (Ca2+)i, the stimulation of Na+/H+ transporter and the inhibition of the effects of thrombin alone on (Ca2+)i are potently antagonised by staurosporine, a compound known to inhibit protein kinase C. Higher concentrations of staurosporine themselves inhibit the thrombin-induced calcium transient.	Staurosporine	309-322	coagulation factor II, thrombin	Homo sapiens	346-354
33498178-5	2021	Intrathecal PAR2-activating peptide (AP) administration aggravated the carrageenan-induced thermal hyperalgesia, and this was prevented by a TRPV1 antagonist (SB 366791) and staurosporine i.t.	Staurosporine	174-187	F2R like trypsin receptor 1	Rattus norvegicus	12-16
34022923-5	2021	In the presence of the apoptotic stimulator, staurosporine, cells treated with elamipretide exhibited moderately slower rates of BAX recruitment.	Staurosporine	45-58	BCL2 associated X, apoptosis regulator	Homo sapiens	129-132
33986607-4	2021	Staurosporine (Stauro) was applied to activate GSK3 by inhibiting kinases that mediate inhibitory GSK3alpha/beta-Ser21/9 phosphorylation (eg, PKC).	Staurosporine	0-13	glycogen synthase kinase 3 alpha	Homo sapiens	98-107
33986607-4	2021	Staurosporine (Stauro) was applied to activate GSK3 by inhibiting kinases that mediate inhibitory GSK3alpha/beta-Ser21/9 phosphorylation (eg, PKC).	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	142-145
33986607-4	2021	Staurosporine (Stauro) was applied to activate GSK3 by inhibiting kinases that mediate inhibitory GSK3alpha/beta-Ser21/9 phosphorylation (eg, PKC).	Staurosporine	0-6	glycogen synthase kinase 3 alpha	Homo sapiens	98-107
33986607-4	2021	Staurosporine (Stauro) was applied to activate GSK3 by inhibiting kinases that mediate inhibitory GSK3alpha/beta-Ser21/9 phosphorylation (eg, PKC).	Staurosporine	0-6	protein kinase C alpha	Homo sapiens	142-145
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Staurosporine	83-96	mitogen-activated protein kinase 1	Homo sapiens	118-121
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Staurosporine	83-96	mitogen-activated protein kinase 1	Homo sapiens	232-235
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Staurosporine	98-101	mitogen-activated protein kinase 1	Homo sapiens	118-121
34051057-6	2021	Additionally, the administration of 12-O-tetradecanoylphorbol 13-acetate (TPA) and staurosporine (STS), activators of ERK signaling, also resulted in a decrease in the levels of both ChREBPalpha and beta mRNA in HepG2 cells through ERK signaling.	Staurosporine	98-101	mitogen-activated protein kinase 1	Homo sapiens	232-235
33691171-7	2021	EGFR expression was negatively associated with drug sensitivity of Pipamperone, Tamoxifen, Bafetinib and positively related to drug sensitivity of Dasatinib and Staurosporine.	Staurosporine	161-174	epidermal growth factor receptor	Homo sapiens	0-4
33964145-7	2021	The RA-induction of SHARP-2 mRNA level was mainly inhibited by LY294002, staurosporine, and actinomycin D, respectively.	Staurosporine	73-86	basic helix-loop-helix family, member e40	Rattus norvegicus	20-27
33180957-0	2021	Ubiquitination and the Proteasome rather than Caspase-3-Mediated C-Terminal Cleavage are Involved in the EAAT2 Degradation by Staurosporine-Induced Cellular Stress.	Staurosporine	126-139	caspase 3	Mus musculus	46-55
33180957-0	2021	Ubiquitination and the Proteasome rather than Caspase-3-Mediated C-Terminal Cleavage are Involved in the EAAT2 Degradation by Staurosporine-Induced Cellular Stress.	Staurosporine	126-139	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	105-110
33498178-7	2021	Additionally, the frequency of the mEPSC and sEPSC and the amplitude of the eEPSC recorded from the superficial dorsal horn neurons were enhanced after acute PAR2 AP application, while prevented with SB 366791 or staurosporine pretreatment.	Staurosporine	213-226	F2R like trypsin receptor 1	Rattus norvegicus	158-162
33577012-6	2021	In addition, T25 cell lines were divided into three groups, including Control group, hypoxia/reoxygenation (H/R) group and H/R + Staurosporine group (an activator of the ERK1/2 signaling pathway).	Staurosporine	129-142	mitogen activated protein kinase 3	Rattus norvegicus	170-176
33206996-3	2021	Using the human promyelocytic cell line HL-60 as a model, we found that overexpression of patient-derived JAGN1 mutants, but not silencing of JAGN1, augmented cell death in response to the pro-apoptotic stimuli, etoposide, staurosporine, and thapsigargin.	Staurosporine	223-236	jagunal homolog 1	Homo sapiens	106-111
33577012-14	2021	Besides, the protein expression levels of ERK1/2 and p-ERK1/2 were markedly up-regulated in Control group when compared with H/R + Staurosporine group, with the lowest in H/R group (p<0.05).	Staurosporine	131-144	mitogen activated protein kinase 3	Rattus norvegicus	42-48
33577012-14	2021	Besides, the protein expression levels of ERK1/2 and p-ERK1/2 were markedly up-regulated in Control group when compared with H/R + Staurosporine group, with the lowest in H/R group (p<0.05).	Staurosporine	131-144	mitogen activated protein kinase 3	Rattus norvegicus	55-61
33161767-4	2021	Based on in silico pharmacokinetic analysis and a common-feature pharmacophore mapping model developed from the Staurosporin, four molecules were proposed as promising Lyn inhibitors.	Staurosporine	112-124	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	168-171
33125833-5	2021	Cells overexpressing AQP1 were exposed to hypotonic or hypertonic medium in the presence or absence of staurosporine or W-7 hydrochloride, and fluorescence imaging was performed at 0, 5, 10, and 15 min later.	Staurosporine	103-116	aquaporin 1 (Colton blood group)	Homo sapiens	21-25
33396658-7	2020	The observed decrease in AAC protein content might be responsible for the decrease of OXPHOS activity and for the observed lowered sensitivity to mitochondrial apoptosis induced by staurosporine or carboxyatractyloside.	Staurosporine	181-194	glycine-N-acyltransferase	Homo sapiens	25-28
32915127-8	2020	Further, the expression of gp38.1 partially reduced staurosporine-induced apoptosis.	Staurosporine	52-65	podoplanin	Homo sapiens	27-31
33168626-7	2021	In the current study, we found that caspase activation by staurosporine- and actinomycin D-induced PARP1 auto-poly(ADP-ribosyl)ation and fragmentation, generating poly(ADP-ribosyl)ated 89-kDa and 24-kDa PARP1 fragments.	Staurosporine	58-71	poly(ADP-ribose) polymerase 1	Homo sapiens	99-104
33168626-7	2021	In the current study, we found that caspase activation by staurosporine- and actinomycin D-induced PARP1 auto-poly(ADP-ribosyl)ation and fragmentation, generating poly(ADP-ribosyl)ated 89-kDa and 24-kDa PARP1 fragments.	Staurosporine	58-71	poly(ADP-ribose) polymerase 1	Homo sapiens	203-208
32777211-9	2020	On the other hand, cell area, circularity or aspect ratio were affected by staurosporine in CXCL8 or CXCL10-activated cells, demonstrating a role of PKCalpha in the rearrangement of the cytoskeleton regardless of the effect on the migration.	Staurosporine	75-88	C-X-C motif chemokine ligand 8	Homo sapiens	92-97
32777211-9	2020	On the other hand, cell area, circularity or aspect ratio were affected by staurosporine in CXCL8 or CXCL10-activated cells, demonstrating a role of PKCalpha in the rearrangement of the cytoskeleton regardless of the effect on the migration.	Staurosporine	75-88	C-X-C motif chemokine ligand 10	Homo sapiens	101-107
32777211-9	2020	On the other hand, cell area, circularity or aspect ratio were affected by staurosporine in CXCL8 or CXCL10-activated cells, demonstrating a role of PKCalpha in the rearrangement of the cytoskeleton regardless of the effect on the migration.	Staurosporine	75-88	protein kinase C alpha	Homo sapiens	149-157
33123123-8	2020	Furthermore, MPI effector cells could likewise engulf RAW-ASC target cell corpses elicited by treatment with staurosporine (apoptosis), LPS, and nigericin (pyroptosis), or cSiO2.	Staurosporine	109-122	steroid sulfatase	Mus musculus	54-61
32791141-9	2020	DLC was shown to enhance cellular susceptibility to apoptosis induced by staurosporine, likely by preventing AIF to maintain mitochondrial oxidative phosphorylation.	Staurosporine	73-86	apoptosis inducing factor mitochondria associated 1	Homo sapiens	109-112
32958707-6	2020	Moreover, co-expression of Bcl-XL and MFN2/MFN1 exhibited the same anti-apoptotic ability as the expression of Bcl-XL alone to staurosporine-induced apoptosis, indicating the full anti-apoptotic ability of Bcl-XL complexed with MFN2 or MFN1.	Staurosporine	127-140	BCL2 like 1	Homo sapiens	27-33
32958707-6	2020	Moreover, co-expression of Bcl-XL and MFN2/MFN1 exhibited the same anti-apoptotic ability as the expression of Bcl-XL alone to staurosporine-induced apoptosis, indicating the full anti-apoptotic ability of Bcl-XL complexed with MFN2 or MFN1.	Staurosporine	127-140	mitofusin 2	Homo sapiens	38-42
32958707-6	2020	Moreover, co-expression of Bcl-XL and MFN2/MFN1 exhibited the same anti-apoptotic ability as the expression of Bcl-XL alone to staurosporine-induced apoptosis, indicating the full anti-apoptotic ability of Bcl-XL complexed with MFN2 or MFN1.	Staurosporine	127-140	mitofusin 1	Homo sapiens	43-47
32958707-6	2020	Moreover, co-expression of Bcl-XL and MFN2/MFN1 exhibited the same anti-apoptotic ability as the expression of Bcl-XL alone to staurosporine-induced apoptosis, indicating the full anti-apoptotic ability of Bcl-XL complexed with MFN2 or MFN1.	Staurosporine	127-140	BCL2 like 1	Homo sapiens	111-117
32958707-6	2020	Moreover, co-expression of Bcl-XL and MFN2/MFN1 exhibited the same anti-apoptotic ability as the expression of Bcl-XL alone to staurosporine-induced apoptosis, indicating the full anti-apoptotic ability of Bcl-XL complexed with MFN2 or MFN1.	Staurosporine	127-140	BCL2 like 1	Homo sapiens	111-117
32627119-5	2020	VSMCs undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 (IL-6) and granulocyte-macrophage colony stimulating factor (GM-CSF), leading to their secretion.	Staurosporine	76-89	interleukin 6	Mus musculus	118-131
32627119-5	2020	VSMCs undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 (IL-6) and granulocyte-macrophage colony stimulating factor (GM-CSF), leading to their secretion.	Staurosporine	76-89	interleukin 6	Mus musculus	133-137
32627119-5	2020	VSMCs undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 (IL-6) and granulocyte-macrophage colony stimulating factor (GM-CSF), leading to their secretion.	Staurosporine	76-89	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	143-191
32627119-5	2020	VSMCs undergoing apoptosis through Fas/CD95 or the protein kinase inhibitor staurosporine transcriptionally activated interleukin 6 (IL-6) and granulocyte-macrophage colony stimulating factor (GM-CSF), leading to their secretion.	Staurosporine	76-89	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	193-199
33024575-4	2020	We show here that the apoptotic stimuli cisplatin and staurosporine induce a Bax/Bak-dependent degradation and subcellular redistribution of nesprin-1 and nesprin-2 but not nesprin-3, of the linker of nucleoskeleton and cytoskeleton (LINC) complex.	Staurosporine	54-67	BCL2-associated X protein	Mus musculus	77-80
33209886-0	2020	Porcine ubiquitin-like protein MNSFbeta promotes cell apoptosis and covalently binds to BCL-G to enhance staurosporine-induced apoptosis.	Staurosporine	105-118	FAU ubiquitin like and ribosomal protein S30 fusion	Homo sapiens	31-39
33209886-0	2020	Porcine ubiquitin-like protein MNSFbeta promotes cell apoptosis and covalently binds to BCL-G to enhance staurosporine-induced apoptosis.	Staurosporine	105-118	BCL2 like 14	Homo sapiens	88-93
32977469-8	2020	TMBIM5-knockout cells were more sensitive to apoptosis elicited by staurosporine and BH3 mimetic inhibitors of Bcl-2 and Bcl-XL.	Staurosporine	67-80	growth hormone inducible transmembrane protein	Homo sapiens	0-6
32977469-8	2020	TMBIM5-knockout cells were more sensitive to apoptosis elicited by staurosporine and BH3 mimetic inhibitors of Bcl-2 and Bcl-XL.	Staurosporine	67-80	BCL2 apoptosis regulator	Homo sapiens	111-116
33024575-4	2020	We show here that the apoptotic stimuli cisplatin and staurosporine induce a Bax/Bak-dependent degradation and subcellular redistribution of nesprin-1 and nesprin-2 but not nesprin-3, of the linker of nucleoskeleton and cytoskeleton (LINC) complex.	Staurosporine	54-67	BCL2-antagonist/killer 1	Mus musculus	81-84
33024575-4	2020	We show here that the apoptotic stimuli cisplatin and staurosporine induce a Bax/Bak-dependent degradation and subcellular redistribution of nesprin-1 and nesprin-2 but not nesprin-3, of the linker of nucleoskeleton and cytoskeleton (LINC) complex.	Staurosporine	54-67	spectrin repeat containing, nuclear envelope 1	Mus musculus	141-150
33024575-4	2020	We show here that the apoptotic stimuli cisplatin and staurosporine induce a Bax/Bak-dependent degradation and subcellular redistribution of nesprin-1 and nesprin-2 but not nesprin-3, of the linker of nucleoskeleton and cytoskeleton (LINC) complex.	Staurosporine	54-67	spectrin repeat containing, nuclear envelope 2	Mus musculus	155-164
32957704-7	2020	Disruption of the actin-based cytoskeleton by the apoptosis-inducing agent staurosporine results in impaired ACKR2 internalization and chemokine degradation that is consistent with the emerging scavenging-independent activity of the receptor in apoptotic neutrophils instrumental for promoting efficient efferocytosis during the resolution of inflammation.	Staurosporine	75-88	atypical chemokine receptor 2	Homo sapiens	109-114
32982774-7	2020	Collectively, these results suggest that the cellular redox status may be one of the critical factors of the apoptotic pathway leading to caspase-3 activation by staurosporine.	Staurosporine	162-175	caspase 3	Homo sapiens	138-147
31818185-12	2020	Our findings suggest a new regulatory link between mitochondria and autophagy through CASP9 activity, especially for the proper operation of the Atg8-family conjugation system and autophagosome closure and maturation.Abbreviations: AA: amino acid; ACD: autophagic cell death; ACTB: actin beta; ANXA5: annexin A5; APAF1: apoptotic peptidase activating factor 1; Atg: autophagy related; ATG16L1: autophagy related 16 like 1; BafA1: bafilomycin A1; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; CARD: caspase recruitment domain containing; CASP: caspase; CM-H2DCFDA: chloromethyl-2",7"-dichlorodihydrofluorescein diacetate; Deltapsim: mitochondrial membrane potential; DN: dominant-negative; DNM1L/DRP1: dynamin 1 like; EBSS: Earle"s balanced salt solution; GABARAP: GABA type A receptor-associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; HCN: hippocampal neural stem cells; IAM: inner autophagosome membrane; INS: insulin; KO: knockout; LEHD: Z-LEHD-fmk; MAP1LC3: microtubule associated protein 1 light chain 3; MFN1: mitofusin 1; MFN2: mitofusin 2; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP1: poly(ADP-ribose) polymerase 1; PBS: phosphate-buffered saline; PE: phosphatidylethanolamine; ROS: reactive oxygen species; sgRNA: single guide RNA; SR-SIM: super-resolution structured illumination microscopy; SQSTM1: sequestosome 1; STS: staurosporine; STX17: syntaxin 17; TMRE: tetramethylrhodamine ethyl ester; TUBB: tubulin beta class I; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type; ZFYVE1/DFCP1: zinc finger FYVE-type containing 1.	Staurosporine	1441-1454	caspase 9	Homo sapiens	86-91
31818185-12	2020	Our findings suggest a new regulatory link between mitochondria and autophagy through CASP9 activity, especially for the proper operation of the Atg8-family conjugation system and autophagosome closure and maturation.Abbreviations: AA: amino acid; ACD: autophagic cell death; ACTB: actin beta; ANXA5: annexin A5; APAF1: apoptotic peptidase activating factor 1; Atg: autophagy related; ATG16L1: autophagy related 16 like 1; BafA1: bafilomycin A1; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; CARD: caspase recruitment domain containing; CASP: caspase; CM-H2DCFDA: chloromethyl-2",7"-dichlorodihydrofluorescein diacetate; Deltapsim: mitochondrial membrane potential; DN: dominant-negative; DNM1L/DRP1: dynamin 1 like; EBSS: Earle"s balanced salt solution; GABARAP: GABA type A receptor-associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; HCN: hippocampal neural stem cells; IAM: inner autophagosome membrane; INS: insulin; KO: knockout; LEHD: Z-LEHD-fmk; MAP1LC3: microtubule associated protein 1 light chain 3; MFN1: mitofusin 1; MFN2: mitofusin 2; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP1: poly(ADP-ribose) polymerase 1; PBS: phosphate-buffered saline; PE: phosphatidylethanolamine; ROS: reactive oxygen species; sgRNA: single guide RNA; SR-SIM: super-resolution structured illumination microscopy; SQSTM1: sequestosome 1; STS: staurosporine; STX17: syntaxin 17; TMRE: tetramethylrhodamine ethyl ester; TUBB: tubulin beta class I; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type; ZFYVE1/DFCP1: zinc finger FYVE-type containing 1.	Staurosporine	1441-1454	cartilage associated protein	Homo sapiens	86-90
33192329-11	2020	Furthermore, both the non-specific kinase inhibitor staurosporine and the selective CaMKII inhibitor AIP inhibited the Ca2+-dependent increase in the pSTX3/STX3 ratio in isolated RBC terminals, while in parallel experiments, AIP suppressed RBC depolarization-evoked exocytosis, measured using membrane capacitance measurements.	Staurosporine	52-65	syntaxin 3	Mus musculus	151-155
32536874-9	2020	In addition to this in vivo data, genistein or staurosporin inhibited upregulation of NMDA NR1 protein and nuclear translocation in vitro after treatment of human neuroblastoma clonal cell cultures (SH-SY5Y) with glutamate or NMDA (4 h).	Staurosporine	47-59	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	91-94
32982774-0	2020	Role of Glutathione Depletion and Reactive Oxygen Species Generation on Caspase-3 Activation: A Study With the Kinase Inhibitor Staurosporine.	Staurosporine	128-141	caspase 3	Homo sapiens	72-81
32982774-5	2020	The introduction of staurosporine significantly decreased the concentration of cellular glutathione and increased the presence of ROS after 3 h. These findings were concurrent with the activation of caspase-3.	Staurosporine	20-33	caspase 3	Homo sapiens	199-208
32848866-9	2020	Chemerin concentration-dependently reduced staurosporine-induced apoptosis in both pulmonary artery and thoracic aorta SMCs.	Staurosporine	43-56	retinoic acid receptor responder 2	Rattus norvegicus	0-8
32714930-7	2020	At the same time, staurosporine, nifedipine, and tunicamycin elicited an intermediate activation of caspase-3.	Staurosporine	18-31	caspase 3	Homo sapiens	100-109
32685004-0	2020	Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis.	Staurosporine	55-67	myosin, heavy polypeptide 9, non-muscle	Mus musculus	8-12
32685004-0	2020	Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis.	Staurosporine	55-67	catenin (cadherin associated protein), beta 1	Mus musculus	21-27
32685004-9	2020	Staurosporine reduced nuclear MYH9 S1943 phosphorylation to inhibit CTNNB1 transcription, Wnt/beta-catenin signaling activation and GC progression in both orthotropic xenograft GC nude mouse and transgenic GC mouse models.	Staurosporine	0-13	myosin, heavy polypeptide 9, non-muscle	Mus musculus	30-34
32685004-9	2020	Staurosporine reduced nuclear MYH9 S1943 phosphorylation to inhibit CTNNB1 transcription, Wnt/beta-catenin signaling activation and GC progression in both orthotropic xenograft GC nude mouse and transgenic GC mouse models.	Staurosporine	0-13	catenin (cadherin associated protein), beta 1	Mus musculus	68-74
32685004-9	2020	Staurosporine reduced nuclear MYH9 S1943 phosphorylation to inhibit CTNNB1 transcription, Wnt/beta-catenin signaling activation and GC progression in both orthotropic xenograft GC nude mouse and transgenic GC mouse models.	Staurosporine	0-13	catenin (cadherin associated protein), beta 1	Mus musculus	94-106
32685004-10	2020	Conclusion: This study identified that nuclear MYH9-induced CTNNB1 expression promotes GC metastasis, which could be inhibited by staurosporine, indicating a novel therapy for GC peritoneal metastasis.	Staurosporine	130-143	myosin, heavy polypeptide 9, non-muscle	Mus musculus	47-51
32685004-10	2020	Conclusion: This study identified that nuclear MYH9-induced CTNNB1 expression promotes GC metastasis, which could be inhibited by staurosporine, indicating a novel therapy for GC peritoneal metastasis.	Staurosporine	130-143	catenin (cadherin associated protein), beta 1	Mus musculus	60-66
32504922-0	2020	Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells.	Staurosporine	0-13	myocyte enhancer factor 2D	Mus musculus	73-78
32504922-4	2020	We screened 3766 compounds with known pharmaceutical activities using this system and selected staurosporine as a potential inducer of the proteolysis of MEF2D.	Staurosporine	95-108	myocyte enhancer factor 2D	Homo sapiens	154-159
32504922-8	2020	We identified the cleavage site of MEF2D-HNRNPUL1 by caspases and confirmed that its caspase cleavage-resistant mutant was resistant to staurosporine-induced proteolysis.	Staurosporine	136-149	myocyte enhancer factor 2D	Homo sapiens	35-40
32504922-8	2020	We identified the cleavage site of MEF2D-HNRNPUL1 by caspases and confirmed that its caspase cleavage-resistant mutant was resistant to staurosporine-induced proteolysis.	Staurosporine	136-149	heterogeneous nuclear ribonucleoprotein U-like 1	Mus musculus	41-49
31448698-8	2020	Finally, 200 ns molecular dynamics (MD) simulations on three top-ranked inhibitors including cucurbitacin I (C-I), nymphaeol A (NA), and staurosporine (SPN) were carried out.	Staurosporine	137-150	DEAF1 transcription factor	Homo sapiens	152-155
32664510-6	2020	Gal-3 also activated intracellular Erk and Akt kinases in both cell lines and furthermore protected cells from acute apoptosis induced by staurosporine but not from serum-starvation induced apoptosis.	Staurosporine	138-151	galectin 3	Homo sapiens	0-5
32533048-0	2020	Alpha1-antitrypsin protects lung cancer cells from staurosporine-induced apoptosis: the role of bacterial lipopolysaccharide.	Staurosporine	51-64	serpin family A member 1	Homo sapiens	0-18
32533048-3	2020	Comparison of cells grown for 3 weeks in a regular medium versus medium supplemented with 2 mg/ml of AAT revealed that in the presence of AAT cells acquire better proliferative properties, resistance to staurosporine (STS)-induced apoptosis, and show higher expression of CLU, a pro-tumorigenic gene coding clusterin protein.	Staurosporine	203-216	serpin family A member 1	Homo sapiens	101-104
32533048-3	2020	Comparison of cells grown for 3 weeks in a regular medium versus medium supplemented with 2 mg/ml of AAT revealed that in the presence of AAT cells acquire better proliferative properties, resistance to staurosporine (STS)-induced apoptosis, and show higher expression of CLU, a pro-tumorigenic gene coding clusterin protein.	Staurosporine	203-216	serpin family A member 1	Homo sapiens	138-141
32533048-3	2020	Comparison of cells grown for 3 weeks in a regular medium versus medium supplemented with 2 mg/ml of AAT revealed that in the presence of AAT cells acquire better proliferative properties, resistance to staurosporine (STS)-induced apoptosis, and show higher expression of CLU, a pro-tumorigenic gene coding clusterin protein.	Staurosporine	218-221	serpin family A member 1	Homo sapiens	101-104
32533048-3	2020	Comparison of cells grown for 3 weeks in a regular medium versus medium supplemented with 2 mg/ml of AAT revealed that in the presence of AAT cells acquire better proliferative properties, resistance to staurosporine (STS)-induced apoptosis, and show higher expression of CLU, a pro-tumorigenic gene coding clusterin protein.	Staurosporine	218-221	serpin family A member 1	Homo sapiens	138-141
32413057-0	2020	Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.	Staurosporine	0-13	serine/threonine kinase 39	Homo sapiens	40-44
32413057-0	2020	Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.	Staurosporine	0-13	odd-skipped related transcription factor 1	Homo sapiens	45-49
32413057-0	2020	Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.	Staurosporine	0-13	solute carrier family 12 member 5	Homo sapiens	78-82
32413057-0	2020	Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1.	Staurosporine	0-13	solute carrier family 12 member 2	Homo sapiens	87-92
32413057-2	2020	Staurosporine (broad kinase inhibitor) and N-ethylmalemide (NEM) that modulate kinase and phosphatase activities enhance KCC2 and decrease NKCC1 activity.	Staurosporine	0-13	solute carrier family 12 member 5	Homo sapiens	121-125
32413057-2	2020	Staurosporine (broad kinase inhibitor) and N-ethylmalemide (NEM) that modulate kinase and phosphatase activities enhance KCC2 and decrease NKCC1 activity.	Staurosporine	0-13	solute carrier family 12 member 2	Homo sapiens	139-144
32413057-4	2020	Our analyses revealed that application of staurosporine or NEM dephosphorylates Thr1007 of KCC2, and Thr203, Thr207 and Thr212 of NKCC1.	Staurosporine	42-55	solute carrier family 12 member 5	Homo sapiens	91-95
32413057-4	2020	Our analyses revealed that application of staurosporine or NEM dephosphorylates Thr1007 of KCC2, and Thr203, Thr207 and Thr212 of NKCC1.	Staurosporine	42-55	solute carrier family 12 member 2	Homo sapiens	130-135
32413057-7	2020	Taken together, these results suggest that reciprocal regulation of KCC2 and NKCC1 via staurosporine and NEM is based on WNK-SPAK/OSR1 signaling.	Staurosporine	87-100	solute carrier family 12 member 5	Homo sapiens	68-72
32413057-7	2020	Taken together, these results suggest that reciprocal regulation of KCC2 and NKCC1 via staurosporine and NEM is based on WNK-SPAK/OSR1 signaling.	Staurosporine	87-100	solute carrier family 12 member 2	Homo sapiens	77-82
32413057-7	2020	Taken together, these results suggest that reciprocal regulation of KCC2 and NKCC1 via staurosporine and NEM is based on WNK-SPAK/OSR1 signaling.	Staurosporine	87-100	serine/threonine kinase 39	Homo sapiens	125-129
32413057-7	2020	Taken together, these results suggest that reciprocal regulation of KCC2 and NKCC1 via staurosporine and NEM is based on WNK-SPAK/OSR1 signaling.	Staurosporine	87-100	odd-skipped related transcription factor 1	Homo sapiens	130-134
32032656-4	2020	STS blocked the activity of TKI-resistant protein kinases and strongly inhibited adaptive dynamics in RCC cells promoted by MDR1 and GLUT1 to overcome sunitinib resistance.	Staurosporine	0-3	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	124-128
32032656-4	2020	STS blocked the activity of TKI-resistant protein kinases and strongly inhibited adaptive dynamics in RCC cells promoted by MDR1 and GLUT1 to overcome sunitinib resistance.	Staurosporine	0-3	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	133-138
32087919-0	2020	Decreased abundance of GDNF mRNA transcript in the immature Sertoli cells of cattle in response to protein kinase inhibitor staurosporine.	Staurosporine	124-137	glial cell derived neurotrophic factor	Bos taurus	23-27
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Staurosporine	26-39	brain-derived neurotrophic factor	Rattus norvegicus	89-93
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Staurosporine	26-39	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	94-98
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Staurosporine	26-39	AKT serine/threonine kinase 1	Rattus norvegicus	99-102
32373755-0	2020	Tea polyphenols attenuate staurosporine-induced cytotoxicity and apoptosis by modulating BDNF-TrkB/Akt and Erk1/2 signaling axis in hippocampal neurons.	Staurosporine	26-39	mitogen activated protein kinase 3	Rattus norvegicus	107-113
32214021-8	2020	Staurosporin increased caspase-3/7 activity (689%) and decreased cell survival by 32%.	Staurosporine	0-12	caspase 3	Homo sapiens	23-32
32087919-0	2020	Decreased abundance of GDNF mRNA transcript in the immature Sertoli cells of cattle in response to protein kinase inhibitor staurosporine.	Staurosporine	124-137	protein kinase cAMP-activated catalytic subunit beta	Bos taurus	99-113
32087919-8	2020	There was subsequent characterization of SC treated with the PK inhibitor staurosporine for 0, 1 or 2 h. Results from real-time-PCR and Western blot analyses indicated the treatment (2 h) resulted in a decrease in Gdnf mRNA transcript and GDNF protein.	Staurosporine	74-87	protein kinase cAMP-activated catalytic subunit beta	Bos taurus	61-63
32087919-8	2020	There was subsequent characterization of SC treated with the PK inhibitor staurosporine for 0, 1 or 2 h. Results from real-time-PCR and Western blot analyses indicated the treatment (2 h) resulted in a decrease in Gdnf mRNA transcript and GDNF protein.	Staurosporine	74-87	glial cell derived neurotrophic factor	Bos taurus	214-218
32087919-8	2020	There was subsequent characterization of SC treated with the PK inhibitor staurosporine for 0, 1 or 2 h. Results from real-time-PCR and Western blot analyses indicated the treatment (2 h) resulted in a decrease in Gdnf mRNA transcript and GDNF protein.	Staurosporine	74-87	glial cell derived neurotrophic factor	Bos taurus	239-243
32087919-9	2020	Additionally, the staurosporine treatment resulted in an increase in the abundance of anti-apoptosis Bcl2 and decrease in pro-apoptosis Bax mRNA transcripts.	Staurosporine	18-31	BCL2 apoptosis regulator	Bos taurus	101-105
32087919-9	2020	Additionally, the staurosporine treatment resulted in an increase in the abundance of anti-apoptosis Bcl2 and decrease in pro-apoptosis Bax mRNA transcripts.	Staurosporine	18-31	BCL2 associated X, apoptosis regulator	Bos taurus	136-139
33654958-5	2019	Apoptosis of Jurkat cells is induced with staurosporine, a protein kinase C (PKC) inhibitor and detected by Annexin V/propidium iodide staining.	Staurosporine	42-55	annexin A5	Homo sapiens	108-117
32032391-8	2020	Less active caspase-8 and caspase-9, and consequently less active caspase-3, was observed in infected compared to uninfected staurosporine-exposed cells.	Staurosporine	125-138	caspase 8	Homo sapiens	12-21
32032391-8	2020	Less active caspase-8 and caspase-9, and consequently less active caspase-3, was observed in infected compared to uninfected staurosporine-exposed cells.	Staurosporine	125-138	caspase 9	Homo sapiens	26-35
32032391-8	2020	Less active caspase-8 and caspase-9, and consequently less active caspase-3, was observed in infected compared to uninfected staurosporine-exposed cells.	Staurosporine	125-138	caspase 3	Homo sapiens	66-75
32032391-9	2020	While staurosporine-exposed uninfected cells showed massive release of pro-apoptotic cytochrome C into the cytosol, this was not observed in infected cells.	Staurosporine	6-19	cytochrome c, somatic	Homo sapiens	85-97
32032391-12	2020	Importantly, direct inhibition of BCL-2 by the inhibitor ABT-737, as well as silencing of BCL-2 by siRNA, resulted in apoptosis in staurosporine-exposed hantavirus-infected cells.	Staurosporine	131-144	BCL2 apoptosis regulator	Homo sapiens	34-39
32032391-12	2020	Importantly, direct inhibition of BCL-2 by the inhibitor ABT-737, as well as silencing of BCL-2 by siRNA, resulted in apoptosis in staurosporine-exposed hantavirus-infected cells.	Staurosporine	131-144	BCL2 apoptosis regulator	Homo sapiens	90-95
32116640-8	2020	Locally-induced CaMKII translocation was moderately suppressed in the presence of either the broad-spectrum kinase inhibitor staurosporine (100 nm) or the CaMKII(281-302) peptide inhibitor.	Staurosporine	125-138	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	16-22
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	0-13	tyrosine hydroxylase	Homo sapiens	69-71
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	0-13	brain derived neurotrophic factor	Homo sapiens	187-219
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	0-13	brain derived neurotrophic factor	Homo sapiens	221-225
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	0-13	tyrosine hydroxylase	Homo sapiens	244-246
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	15-17	tyrosine hydroxylase	Homo sapiens	69-71
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	15-17	brain derived neurotrophic factor	Homo sapiens	187-219
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	15-17	brain derived neurotrophic factor	Homo sapiens	221-225
32640966-7	2020	Staurosporine (ST)-differentiation resulted in the highest number of TH-immunoreactive cells, followed by phorbol ester phorbol-12-myristate-13-acetat (PMA), whereas differentiation with brain-derived neurotropic factor (BDNF) did not increase TH-immunoreactive cells.	Staurosporine	15-17	tyrosine hydroxylase	Homo sapiens	244-246
31648640-7	2020	A docking study was performed by using the crystallographic structure of the staurosporine/GSK-3beta complex [Protein Data Bank (PDB) code: 1Q3D].	Staurosporine	77-90	glycogen synthase kinase 3 alpha	Homo sapiens	91-100
31817728-4	2019	This nonsynonymous amino acid substitution in a low complexity region of CZT-1/ACR-3 caused a robust gain-of-function that led to reduced sensitivity to acriflavine and staurosporine, and increased expression of the drug efflux pump abc-3.	Staurosporine	169-182	ATP binding cassette subfamily A member 3	Homo sapiens	233-238
30894073-6	2019	Given our result that staurosporine (STS) treatment induced the degradation of MIEF1 via the ubiquitin-proteasome system (UPS), we are motivated to explore the role of MIEF1 in apoptosis.	Staurosporine	22-35	mitochondrial elongation factor 1	Homo sapiens	79-84
30894073-6	2019	Given our result that staurosporine (STS) treatment induced the degradation of MIEF1 via the ubiquitin-proteasome system (UPS), we are motivated to explore the role of MIEF1 in apoptosis.	Staurosporine	37-40	mitochondrial elongation factor 1	Homo sapiens	79-84
30894073-6	2019	Given our result that staurosporine (STS) treatment induced the degradation of MIEF1 via the ubiquitin-proteasome system (UPS), we are motivated to explore the role of MIEF1 in apoptosis.	Staurosporine	37-40	mitochondrial elongation factor 1	Homo sapiens	168-173
31024074-6	2019	While CM from Tsc1-/- fibroblasts promoted tubular cell c-met signaling activation and inhibited staurosporine-induced cell apoptosis.	Staurosporine	97-110	TSC complex subunit 1	Mus musculus	14-18
31783714-2	2019	The initial CHK1 inhibitor staurosporine analog, UCN01, entered clinical trials whilst it was still considered to act via PKC inhibition; only later were trials performed in a more focused fashion to determine whether CHK1 inhibition could dysregulate cell cycle checkpoints.	Staurosporine	27-40	checkpoint kinase 1	Homo sapiens	12-16
31783714-2	2019	The initial CHK1 inhibitor staurosporine analog, UCN01, entered clinical trials whilst it was still considered to act via PKC inhibition; only later were trials performed in a more focused fashion to determine whether CHK1 inhibition could dysregulate cell cycle checkpoints.	Staurosporine	27-40	checkpoint kinase 1	Homo sapiens	218-222
31766614-8	2019	In addition, ProS1 protected cancer cells from acute apoptosis induced by staurosporine, as well as additionally, long-term serum starvation-induced apoptosis in MGH-U3 cells (Tyro3 only), which reflects its additional coupling to Akt signalling in these cells.	Staurosporine	74-87	protein S	Homo sapiens	13-18
31652302-6	2019	Finally, crystal structures of the LIMK1 kinase domain in complex with inhibitors (PF-477736 and staurosporine, respectively) are presented, providing insights into LIMK1 plasticity upon inhibitor binding.	Staurosporine	97-110	LIM domain kinase 1	Homo sapiens	35-40
31652302-6	2019	Finally, crystal structures of the LIMK1 kinase domain in complex with inhibitors (PF-477736 and staurosporine, respectively) are presented, providing insights into LIMK1 plasticity upon inhibitor binding.	Staurosporine	97-110	LIM domain kinase 1	Homo sapiens	165-170
31344401-10	2019	We also demonstrated CytC release from damaged glial cells by measuring CytC in the supernatants of BV-2 microglia after their exposure to cytotoxic concentrations of staurosporine, amyloid-beta peptides (Abeta42) and tumor necrosis factor-alpha.	Staurosporine	167-180	cytochrome c, somatic	Homo sapiens	21-25
31683713-5	2019	Furthermore, we examine whether HtrA2 is released extracellularly after staurosporine-induced apoptosis using ELISA.	Staurosporine	72-85	HtrA serine peptidase 2	Homo sapiens	32-37
31683713-6	2019	We find that HtrA2 is released upon induction of apoptosis by staurosporine into the cell culture medium.	Staurosporine	62-75	HtrA serine peptidase 2	Homo sapiens	13-18
31683713-7	2019	Furthermore, treatment of HUVECs with extracellular HtrA2-induces apoptosis, while the addition of anti-HtrA2 antibodies reduces both HtrA2- and staurosporine-induced endothelial cell apoptosis.	Staurosporine	145-158	HtrA serine peptidase 2	Homo sapiens	104-109
31683713-7	2019	Furthermore, treatment of HUVECs with extracellular HtrA2-induces apoptosis, while the addition of anti-HtrA2 antibodies reduces both HtrA2- and staurosporine-induced endothelial cell apoptosis.	Staurosporine	145-158	HtrA serine peptidase 2	Homo sapiens	104-109
31321477-10	2019	In vitro functional experiments showed that APAF1 depletion increased the tumor potency of cells expressing NAB2-STAT6 fusion protein under treatment with staurosporine.	Staurosporine	155-168	apoptotic peptidase activating factor 1	Homo sapiens	44-49
31321477-10	2019	In vitro functional experiments showed that APAF1 depletion increased the tumor potency of cells expressing NAB2-STAT6 fusion protein under treatment with staurosporine.	Staurosporine	155-168	NGFI-A binding protein 2	Homo sapiens	108-112
31321477-10	2019	In vitro functional experiments showed that APAF1 depletion increased the tumor potency of cells expressing NAB2-STAT6 fusion protein under treatment with staurosporine.	Staurosporine	155-168	signal transducer and activator of transcription 6	Homo sapiens	113-118
31497236-7	2019	Furthermore, treatment with the serine/threonine kinase inhibitor staurosporine (STS; 2 nmol/L, 8 h) significantly decreased the levels of p-TOB1.	Staurosporine	66-79	transducer of ERBB2, 1	Homo sapiens	141-145
31207272-5	2019	In an overexpression system of Xenopus oocytes, hydrocortisone increased hERG K+ currents and reduced Kv1.5 K+ currents; these effects were negated by pretreatment with staurosporine.	Staurosporine	169-182	ETS transcription factor ERG	Homo sapiens	73-77
31207272-5	2019	In an overexpression system of Xenopus oocytes, hydrocortisone increased hERG K+ currents and reduced Kv1.5 K+ currents; these effects were negated by pretreatment with staurosporine.	Staurosporine	169-182	potassium voltage-gated channel subfamily A member 4 L homeolog	Xenopus laevis	102-107
31085166-10	2019	Moreover, treatments with DRP1 inhibitor, mdivi-1, or with DRP1-targetted siRNA efficiently prevent silibinin-induced apoptosis in the breast cancer cells, whereas inhibition of DRP1 phosphorylation with staurosporine increases apoptosis furthermore.	Staurosporine	204-217	dynamin 1 like	Homo sapiens	59-63
31085166-10	2019	Moreover, treatments with DRP1 inhibitor, mdivi-1, or with DRP1-targetted siRNA efficiently prevent silibinin-induced apoptosis in the breast cancer cells, whereas inhibition of DRP1 phosphorylation with staurosporine increases apoptosis furthermore.	Staurosporine	204-217	dynamin 1 like	Homo sapiens	59-63
31497236-7	2019	Furthermore, treatment with the serine/threonine kinase inhibitor staurosporine (STS; 2 nmol/L, 8 h) significantly decreased the levels of p-TOB1.	Staurosporine	81-84	transducer of ERBB2, 1	Homo sapiens	141-145
30346568-9	2019	Histopathological features of immune-mediated organ damage were evident in pristane-induced and NS1-induced ApoBod groups; severity scores were higher in these groups than in staurosporine-treated groups.	Staurosporine	175-188	influenza virus NS1A binding protein	Mus musculus	96-99
30614533-9	2019	In addition, knockdown of EMP3 resulted in reduced levels of p-AKT, p-ERK and p-EGFR, attenuated cell proliferation and migration and sensitized cells to apoptosis induction by TRAIL and Staurosporine.	Staurosporine	187-200	epithelial membrane protein 3	Homo sapiens	26-30
31250620-6	2019	To investigate the involvement of inositol triphosphate (IP3), Rho kinase, and protein kinase C (PKC) in ghrelin-mediated pacemaker potential depolarization of ICCs, we used the IP3 receptor inhibitors 2-aminoethoxydiphenyl borate and xestospongin C, the Rho kinase inhibitor Y-27632, and the PKC inhibitors staurosporine, Go6976, and rottlerin.	Staurosporine	308-321	ghrelin	Mus musculus	105-112
30894323-9	2019	The protein kinase inhibitor staurosporine inhibited the induction of all three genes by PMA but only that of HMOX1 by LPS.	Staurosporine	29-42	heme oxygenase 1	Mus musculus	110-115
30942074-4	2019	In the real-time fluorescence imaging of apoptotic HeLa cells induced by staurosporine using GNP-Se-Casp, the fluorescence signals corresponding to casp-8 and casp-9 sequentially turn on, followed by the appearance of the fluorescence of casp-3, which visualizes the upstream and downstream relationships of casp-3, -8, and -9.	Staurosporine	73-86	cartilage associated protein	Homo sapiens	100-104
30942074-4	2019	In the real-time fluorescence imaging of apoptotic HeLa cells induced by staurosporine using GNP-Se-Casp, the fluorescence signals corresponding to casp-8 and casp-9 sequentially turn on, followed by the appearance of the fluorescence of casp-3, which visualizes the upstream and downstream relationships of casp-3, -8, and -9.	Staurosporine	73-86	caspase 8	Homo sapiens	148-154
30942074-4	2019	In the real-time fluorescence imaging of apoptotic HeLa cells induced by staurosporine using GNP-Se-Casp, the fluorescence signals corresponding to casp-8 and casp-9 sequentially turn on, followed by the appearance of the fluorescence of casp-3, which visualizes the upstream and downstream relationships of casp-3, -8, and -9.	Staurosporine	73-86	caspase 9	Homo sapiens	159-165
30942074-4	2019	In the real-time fluorescence imaging of apoptotic HeLa cells induced by staurosporine using GNP-Se-Casp, the fluorescence signals corresponding to casp-8 and casp-9 sequentially turn on, followed by the appearance of the fluorescence of casp-3, which visualizes the upstream and downstream relationships of casp-3, -8, and -9.	Staurosporine	73-86	caspase 3	Homo sapiens	238-244
30942074-4	2019	In the real-time fluorescence imaging of apoptotic HeLa cells induced by staurosporine using GNP-Se-Casp, the fluorescence signals corresponding to casp-8 and casp-9 sequentially turn on, followed by the appearance of the fluorescence of casp-3, which visualizes the upstream and downstream relationships of casp-3, -8, and -9.	Staurosporine	73-86	caspase 3	Homo sapiens	308-326
31138954-8	2019	Consistently, NUPR1 knockdown was found to reduce cell proliferation and increase the proapoptotic effect of staurosporine, suggesting that deferoxamine-induced NUPR1 promotes mesenchymal stem cell survival and cytoprotective autophagy.	Staurosporine	109-122	nuclear protein 1, transcriptional regulator	Homo sapiens	14-19
31138954-8	2019	Consistently, NUPR1 knockdown was found to reduce cell proliferation and increase the proapoptotic effect of staurosporine, suggesting that deferoxamine-induced NUPR1 promotes mesenchymal stem cell survival and cytoprotective autophagy.	Staurosporine	109-122	nuclear protein 1, transcriptional regulator	Homo sapiens	161-166
31024909-3	2019	Namely, IL-4 (8D4-8) expression was observed in the absence of cellular activation and enhanced following staurosporine exposure.	Staurosporine	106-119	interleukin 4	Homo sapiens	8-12
30827509-4	2019	Co-expression of Bcl-XL and Beclin-1 exhibited consistent anti-apoptotic ability against staurosporine (STS)-induced apoptosis with expression of Bcl-XL alone irrespective of the relative expression level between Beclin-1 and Bcl-XL.	Staurosporine	89-102	BCL2 like 1	Homo sapiens	17-23
30827509-4	2019	Co-expression of Bcl-XL and Beclin-1 exhibited consistent anti-apoptotic ability against staurosporine (STS)-induced apoptosis with expression of Bcl-XL alone irrespective of the relative expression level between Beclin-1 and Bcl-XL.	Staurosporine	89-102	beclin 1	Homo sapiens	28-36
30827509-4	2019	Co-expression of Bcl-XL and Beclin-1 exhibited consistent anti-apoptotic ability against staurosporine (STS)-induced apoptosis with expression of Bcl-XL alone irrespective of the relative expression level between Beclin-1 and Bcl-XL.	Staurosporine	104-107	BCL2 like 1	Homo sapiens	17-23
30827509-4	2019	Co-expression of Bcl-XL and Beclin-1 exhibited consistent anti-apoptotic ability against staurosporine (STS)-induced apoptosis with expression of Bcl-XL alone irrespective of the relative expression level between Beclin-1 and Bcl-XL.	Staurosporine	104-107	beclin 1	Homo sapiens	28-36
30447001-8	2019	Both 5-HT and sumatriptan induced significant heterologous desensitization of SRIF (somatostatin)-activated GIRK currents, with the 5-HT-induced heterologous desensitization being blocked by the protein kinase inhibitor staurosporine.	Staurosporine	220-233	somatostatin	Mus musculus	78-82
30756209-9	2019	Apoptotic response to staurosporine was significantly lower in NAC (20 +- 32 vs. 125 +- 32%).	Staurosporine	22-35	synuclein alpha	Homo sapiens	63-66
30690742-5	2019	Dynamical E-FRET imaging on the microscope for live cells coexpressing CFP-Bax and YFP-Bax treated by staurosporine (STS) revealed three Bax redistribution stages: Bax translocation from cytosol to mitochondria within 10 min, membrane insertion with conformational change on mitochondrial membrane within about 30 min, and subsequent oligomerisation within about 10 min.	Staurosporine	102-115	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
30690742-5	2019	Dynamical E-FRET imaging on the microscope for live cells coexpressing CFP-Bax and YFP-Bax treated by staurosporine (STS) revealed three Bax redistribution stages: Bax translocation from cytosol to mitochondria within 10 min, membrane insertion with conformational change on mitochondrial membrane within about 30 min, and subsequent oligomerisation within about 10 min.	Staurosporine	102-115	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
30690742-5	2019	Dynamical E-FRET imaging on the microscope for live cells coexpressing CFP-Bax and YFP-Bax treated by staurosporine (STS) revealed three Bax redistribution stages: Bax translocation from cytosol to mitochondria within 10 min, membrane insertion with conformational change on mitochondrial membrane within about 30 min, and subsequent oligomerisation within about 10 min.	Staurosporine	102-115	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
30690742-5	2019	Dynamical E-FRET imaging on the microscope for live cells coexpressing CFP-Bax and YFP-Bax treated by staurosporine (STS) revealed three Bax redistribution stages: Bax translocation from cytosol to mitochondria within 10 min, membrane insertion with conformational change on mitochondrial membrane within about 30 min, and subsequent oligomerisation within about 10 min.	Staurosporine	117-120	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
30690742-5	2019	Dynamical E-FRET imaging on the microscope for live cells coexpressing CFP-Bax and YFP-Bax treated by staurosporine (STS) revealed three Bax redistribution stages: Bax translocation from cytosol to mitochondria within 10 min, membrane insertion with conformational change on mitochondrial membrane within about 30 min, and subsequent oligomerisation within about 10 min.	Staurosporine	117-120	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
30690742-5	2019	Dynamical E-FRET imaging on the microscope for live cells coexpressing CFP-Bax and YFP-Bax treated by staurosporine (STS) revealed three Bax redistribution stages: Bax translocation from cytosol to mitochondria within 10 min, membrane insertion with conformational change on mitochondrial membrane within about 30 min, and subsequent oligomerisation within about 10 min.	Staurosporine	117-120	BCL2 associated X, apoptosis regulator	Homo sapiens	87-90
30703525-8	2019	Yet on the protein level, treatment of trout cell line RT-gill-W1 with 1 muM staurosporine for up to 120 min led to a significant increase of CASP3/7 activity.	Staurosporine	77-90	caspase-3b	Oncorhynchus mykiss	142-147
30776542-3	2019	To further reveal the mediated mechanism that Nrf2 active state was affected by protein kinase C (PKC), here we evaluated SVCV replication in host cells by treated with a strong activator of PKC phorbol-12-myristate-13-acetate (PMA) and an inhibitor staurosporine.	Staurosporine	250-263	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
30776542-3	2019	To further reveal the mediated mechanism that Nrf2 active state was affected by protein kinase C (PKC), here we evaluated SVCV replication in host cells by treated with a strong activator of PKC phorbol-12-myristate-13-acetate (PMA) and an inhibitor staurosporine.	Staurosporine	250-263	protein kinase C alpha	Homo sapiens	98-101
30488656-11	2019	Treatment of patient cells with MG-132 or staurosporine to induce activation of the intrinsic apoptosis pathway revealed significantly decreased cell viability with increased caspase-3 and caspase-7 activation.	Staurosporine	42-55	caspase 3	Homo sapiens	175-184
30488656-11	2019	Treatment of patient cells with MG-132 or staurosporine to induce activation of the intrinsic apoptosis pathway revealed significantly decreased cell viability with increased caspase-3 and caspase-7 activation.	Staurosporine	42-55	caspase 7	Homo sapiens	189-198
30906214-9	2019	Electron microscopy analysis revealed large empty autophagosomes in FHL2-silenced myoblasts, while flow cytometry suggested that FHL2 silencing made cells more vulnerable to staurosporine-induced cell death.	Staurosporine	174-187	four and a half LIM domains 2	Mus musculus	129-133
30977989-8	2019	After re-oxygenation, staurosporine served to induce apoptosis, quantified by active caspase-3.	Staurosporine	22-35	caspase 3	Mus musculus	85-94
30686270-8	2019	Staurosporine stimulation and its effects on the expression of Bcl2, BAX, Bad, caspase-8, and caspase-9 were investigated with immunoblot.	Staurosporine	0-13	BCL2 apoptosis regulator	Homo sapiens	63-67
30686270-8	2019	Staurosporine stimulation and its effects on the expression of Bcl2, BAX, Bad, caspase-8, and caspase-9 were investigated with immunoblot.	Staurosporine	0-13	BCL2 associated X, apoptosis regulator	Homo sapiens	69-72
30686270-8	2019	Staurosporine stimulation and its effects on the expression of Bcl2, BAX, Bad, caspase-8, and caspase-9 were investigated with immunoblot.	Staurosporine	0-13	caspase 8	Homo sapiens	79-88
30686270-8	2019	Staurosporine stimulation and its effects on the expression of Bcl2, BAX, Bad, caspase-8, and caspase-9 were investigated with immunoblot.	Staurosporine	0-13	caspase 9	Homo sapiens	94-103
30686270-10	2019	Western blot analysis showed activation of caspase-9 in PaTu 8988t and Panc-1 cells with 1 microM staurosporine.	Staurosporine	98-111	caspase 9	Homo sapiens	43-52
30289248-11	2019	Meanwhile, caspase-3 in staurosporine-treated A549 cells are also determined by the approach, and the obtained results agree well with the fluorescent intensity of confocal images, manifesting that the proposed PEC method can monitor apoptosis in a label-free strategy.	Staurosporine	24-37	caspase 3	Homo sapiens	11-20
30977989-14	2019	Staurosporine-induced active caspase-3 was highest after sustained, and lowest after episodic hypoxia.	Staurosporine	0-13	caspase 3	Mus musculus	29-38
30542510-5	2018	Our findings further suggest that inhibiting HUNK with staurosporine has a strong effect on suppressing cell viability of HER2/neu mammary and breast cancer cells, which express high levels of HUNK protein and are dependent on HUNK for survival.	Staurosporine	55-68	hormonally up-regulated Neu-associated kinase	Homo sapiens	45-49
30725416-12	2019	AdMETase/SeMET therapy was effective against Bcl-2-overproducing A549 lung cancer cells, which were resistant to staurosporine-induced apoptosis, with a strong bystander effect.	Staurosporine	113-126	BCL2 apoptosis regulator	Homo sapiens	45-50
30099027-5	2018	We observed an inhibition of cell apoptosis induced by serum starvation or staurosporine upon treatment with exogenous FGF1 or FGF2, despite the presence of highly potent FGFR inhibitors.	Staurosporine	75-88	fibroblast growth factor 1	Homo sapiens	119-123
30099027-5	2018	We observed an inhibition of cell apoptosis induced by serum starvation or staurosporine upon treatment with exogenous FGF1 or FGF2, despite the presence of highly potent FGFR inhibitors.	Staurosporine	75-88	fibroblast growth factor 2	Homo sapiens	127-131
30774867-6	2019	A peptide corresponding to the iASPP 764-780 sequence stabilized the NAF-1 cluster, inhibited NAF-1 interaction with iASPP, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in PC-3 prostate cancer cells in which p53 is inactive.	Staurosporine	138-151	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	31-36
30774867-6	2019	A peptide corresponding to the iASPP 764-780 sequence stabilized the NAF-1 cluster, inhibited NAF-1 interaction with iASPP, and inhibited staurosporine-induced apoptosis activation in human breast cancer, as well as in PC-3 prostate cancer cells in which p53 is inactive.	Staurosporine	138-151	tumor protein p53	Homo sapiens	255-258
30542510-3	2018	A recent study showed that the broad-spectrum kinase inhibitor staurosporine binds to the HUNK catalytic domain, but the effect of staurosporine on HUNK enzymatic activity was not tested.	Staurosporine	63-76	hormonally up-regulated Neu-associated kinase	Homo sapiens	90-94
30542510-3	2018	A recent study showed that the broad-spectrum kinase inhibitor staurosporine binds to the HUNK catalytic domain, but the effect of staurosporine on HUNK enzymatic activity was not tested.	Staurosporine	131-144	hormonally up-regulated Neu-associated kinase	Homo sapiens	148-152
30542510-4	2018	We now show that staurosporine inhibits the kinase activity of a full length HUNK protein.	Staurosporine	17-30	hormonally up-regulated Neu-associated kinase	Homo sapiens	77-81
30201606-6	2018	Additionally, we show that the indirect actions of the known KCC2 activators staurosporine and N-ethylmaleimide (NEM) involved multiple phosphosites.	Staurosporine	77-90	solute carrier family 12 member 5	Homo sapiens	61-65
30201606-8	2018	This demonstrates for the first time differential effects of staurosporine and NEM on KCC2.	Staurosporine	61-74	solute carrier family 12 member 5	Homo sapiens	86-90
30201606-9	2018	In addition, the staurosporine-mediated effects involved both KCC2 phosphorylation and dephosphorylation with Ser932 and Thr1008 being bona fide target sites.	Staurosporine	17-30	solute carrier family 12 member 5	Homo sapiens	62-66
30542510-5	2018	Our findings further suggest that inhibiting HUNK with staurosporine has a strong effect on suppressing cell viability of HER2/neu mammary and breast cancer cells, which express high levels of HUNK protein and are dependent on HUNK for survival.	Staurosporine	55-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-126
30542510-5	2018	Our findings further suggest that inhibiting HUNK with staurosporine has a strong effect on suppressing cell viability of HER2/neu mammary and breast cancer cells, which express high levels of HUNK protein and are dependent on HUNK for survival.	Staurosporine	55-68	hormonally up-regulated Neu-associated kinase	Homo sapiens	193-197
30542510-5	2018	Our findings further suggest that inhibiting HUNK with staurosporine has a strong effect on suppressing cell viability of HER2/neu mammary and breast cancer cells, which express high levels of HUNK protein and are dependent on HUNK for survival.	Staurosporine	55-68	hormonally up-regulated Neu-associated kinase	Homo sapiens	193-197
30542510-6	2018	Significantly, we use in vitro and in vivo methods to show that staurosporine synergizes with the HER2 inhibitor lapatinib to restore sensitivity toward HER2 inhibition in a HER2 inhibitor resistant breast cancer model.	Staurosporine	64-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
30542510-6	2018	Significantly, we use in vitro and in vivo methods to show that staurosporine synergizes with the HER2 inhibitor lapatinib to restore sensitivity toward HER2 inhibition in a HER2 inhibitor resistant breast cancer model.	Staurosporine	64-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
29885518-4	2018	The mGluR8-downregulated SH-SY5Y clones proliferated faster and were more resistant to cytotoxic action of staurosporine, doxorubicin, irinotecan and cisplatin when compared to control cells.	Staurosporine	107-120	glutamate receptor, metabotropic 8	Mus musculus	4-10
30312120-3	2018	In addition, EDM tissues with a 24-h ripasudil treatment and control tissues were exposed to 1 muM staurosporine to induce apoptosis and then analyzed for cell viability using apoptosis and necrosis assays.	Staurosporine	99-112	latexin	Homo sapiens	95-98
30106434-0	2018	Staurosporine alleviates cisplatin chemoresistance in human cancer cell models by suppressing the induction of SQSTM1/p62.	Staurosporine	0-13	sequestosome 1	Homo sapiens	111-117
30106434-0	2018	Staurosporine alleviates cisplatin chemoresistance in human cancer cell models by suppressing the induction of SQSTM1/p62.	Staurosporine	0-13	sequestosome 1	Homo sapiens	118-121
29885518-6	2018	The mGluR8-downregulated LN229 clones migrated faster and were less prone to cell-damaging effect of staurosporine and irinotecan when compared with relevant control cells.	Staurosporine	101-114	glutamate receptor, metabotropic 8	Mus musculus	4-10
29908160-4	2018	In current study, staurosporine (Stau) induced DeltaTau generation by caspases in SH-SY5Y cells with tau overexpression was found to be accompanied by a dramatic dephosphorylation at S422 and the epitope of the diagnostic antibody AT8 (S199 + S202 + T205), but a moderate dephosphorylation of PHF1 (S396 + S404) epitope.	Staurosporine	18-31	PHD finger protein 1	Homo sapiens	293-297
30231889-10	2018	Decreases in ARNT2 secondary to staurosporine and H2O2 preceded increases in cleaved caspase 3 and associated apoptosis.	Staurosporine	32-45	aryl hydrocarbon receptor nuclear translocator 2	Homo sapiens	13-18
29981339-7	2018	Small interference RNA (siRNA)-mediated loss of function studies revealed that knockdown of IGFBP1 reduced apoptosis induced by either thapsigargin (TG) or staurosporine (STS).	Staurosporine	156-169	insulin like growth factor binding protein 1	Homo sapiens	92-98
29981339-7	2018	Small interference RNA (siRNA)-mediated loss of function studies revealed that knockdown of IGFBP1 reduced apoptosis induced by either thapsigargin (TG) or staurosporine (STS).	Staurosporine	171-174	insulin like growth factor binding protein 1	Homo sapiens	92-98
29717153-7	2018	Furthermore, the increased expression of the CF induced by A2A R activation was remarkably inhibited in hypoxic-BV2 cells administrated with the PKA inhibitor H-89 and the PKC inhibitor staurosporine.	Staurosporine	186-199	cystatin F (leukocystatin)	Mus musculus	45-47
29684585-7	2018	Besides, combinatory treatment with siR-Nogo-B/staurosporine (STS) or siR-Nogo-B/Fas ligand (FasL) synergistically reduced cell viability and increased the expression of apoptotic signaling proteins in colorectal cancer cells.	Staurosporine	47-60	reticulon 4	Homo sapiens	40-44
29685892-6	2018	Our results reveal that isoform 1 is an anti-apoptotic factor that inhibits staurosporine- and TNF-related apoptosis-inducing ligand (TRAIL; also known as TNFSF10)-induced apoptosis.	Staurosporine	76-89	TNF superfamily member 10	Homo sapiens	134-139
29685892-6	2018	Our results reveal that isoform 1 is an anti-apoptotic factor that inhibits staurosporine- and TNF-related apoptosis-inducing ligand (TRAIL; also known as TNFSF10)-induced apoptosis.	Staurosporine	76-89	TNF superfamily member 10	Homo sapiens	155-162
29867346-8	2018	Staurosporine aglycon, on the other hand decreased desensitization of heteromeric alpha1-beta GlyRs.	Staurosporine	0-13	adrenoceptor alpha 1D	Homo sapiens	82-88
29449307-5	2018	Furthermore, RAGE deletion conferred a more proliferative phenotype in MCs and reduced susceptibility to staurosporine-induced apoptosis.	Staurosporine	105-118	advanced glycosylation end product-specific receptor	Mus musculus	13-17
29538087-8	2018	Transfection of hsa-miR-320d and hsa-miR-582 did not affect the migration capability of the vascular smooth muscle cells, but remarkably enhanced the staurosporine and tumor necrosis factor-alpha-induced apoptosis by 15% and 29%, respectively.	Staurosporine	150-163	microRNA 582	Homo sapiens	33-44
30106434-7	2018	Conversely, treatment with staurosporine resulted in a marked reduction in p62 levels in all three cell types and abrogated the cisplatin-induced upregulation of p62.	Staurosporine	27-40	sequestosome 1	Homo sapiens	75-78
30106434-7	2018	Conversely, treatment with staurosporine resulted in a marked reduction in p62 levels in all three cell types and abrogated the cisplatin-induced upregulation of p62.	Staurosporine	27-40	sequestosome 1	Homo sapiens	162-165
30106434-8	2018	These results suggest that staurosporine could sensitize cancer cells to cisplatin via a mechanism involving downregulation of p62.	Staurosporine	27-40	sequestosome 1	Homo sapiens	127-130
29107935-8	2018	These compounds also activated caspase-3 but an apoptosis-like type of cell death was unlike since PARP protein was not cleaved and caspase activation was substantially lower than its activation induced by staurosporine, a known caspase-3 activator in T24 cells.	Staurosporine	206-219	caspase 3	Homo sapiens	229-238
29072256-6	2018	Pretreatment with PKC inhibitor staurosporine significantly reduced ox-LDL-stimulated adhesion molecule expression and macrophage adhesion to endothelial cells, whereas pretreatment with PKC activator PMA/TPA attenuated the inhibitory effect of rapamycin on adhesion molecule expression.	Staurosporine	32-45	proline rich transmembrane protein 2	Homo sapiens	18-21
28993291-3	2018	We conducted an analysis of 28 crystal structures of the serine-threonine kinase, p21-activated kinase 4 (PAK4), including three newly determined structures in complex with staurosporine, FRAX486, and fasudil (HA-1077).	Staurosporine	173-186	p21 (RAC1) activated kinase 4	Homo sapiens	82-104
28993291-3	2018	We conducted an analysis of 28 crystal structures of the serine-threonine kinase, p21-activated kinase 4 (PAK4), including three newly determined structures in complex with staurosporine, FRAX486, and fasudil (HA-1077).	Staurosporine	173-186	p21 (RAC1) activated kinase 4	Homo sapiens	106-110
29414524-9	2018	The mRNA expression of GABAA receptor subunit alpha1 increased only in the presence of staurosporine, whereas the expressions of subunits gamma2 and delta significantly increased in the presence of either KG-501 or staurosporine.	Staurosporine	215-228	crystallin, gamma E	Rattus norvegicus	138-144
29242192-0	2018	The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death.	Staurosporine	114-127	PTEN induced kinase 1	Homo sapiens	101-106
29242192-6	2018	Moreover, PINK1 levels were strongly reduced in HEK293 and SH-SY5Y cells exposed to the apoptosis-inducer staurosporine.	Staurosporine	106-119	PTEN induced kinase 1	Homo sapiens	10-15
29242192-9	2018	Taken together, these findings suggest that CHIP plays a role in negative regulation of PINK1 stability and may suppress PINK1"s cytoprotective effect during staurosporine-induced mammalian cell death.	Staurosporine	158-171	PTEN induced kinase 1	Homo sapiens	121-126
29134661-10	2018	Connversely, activation of PLA2 or application of active PLA2 , as well as lipid peroxidation induced by reactive oxygen species (ROS) using staurosporine or tert-butyl hydroperoxide, enhanced ion currents by TMEM16A/F and in addition activated phospholipid scrambling by TMEM16F.	Staurosporine	141-154	anoctamin 1	Homo sapiens	209-216
29134661-10	2018	Connversely, activation of PLA2 or application of active PLA2 , as well as lipid peroxidation induced by reactive oxygen species (ROS) using staurosporine or tert-butyl hydroperoxide, enhanced ion currents by TMEM16A/F and in addition activated phospholipid scrambling by TMEM16F.	Staurosporine	141-154	anoctamin 6	Homo sapiens	272-279
30618318-0	2018	Low-dose staurosporine selectively reverses BCR-ABL-independent IM resistance through PKC-alpha-mediated G2/M phase arrest in chronic myeloid leukaemia.	Staurosporine	9-22	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	44-51
30618318-0	2018	Low-dose staurosporine selectively reverses BCR-ABL-independent IM resistance through PKC-alpha-mediated G2/M phase arrest in chronic myeloid leukaemia.	Staurosporine	9-22	protein kinase C alpha	Homo sapiens	86-95
30618318-4	2018	Therefore, we herein used a PKC pan-inhibitor staurosporine (St).	Staurosporine	46-59	protein kinase C alpha	Homo sapiens	28-31
30618318-4	2018	Therefore, we herein used a PKC pan-inhibitor staurosporine (St).	Staurosporine	61-63	protein kinase C alpha	Homo sapiens	28-31
29519914-3	2018	A molecular model for the catalytic OST subunit STT3A (staurosporine and temperature sensitive 3A) revealed how it is integrated into the OST and how STT3-paralog specificity for translocon-associated OST is achieved.	Staurosporine	55-68	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	36-39
29519914-3	2018	A molecular model for the catalytic OST subunit STT3A (staurosporine and temperature sensitive 3A) revealed how it is integrated into the OST and how STT3-paralog specificity for translocon-associated OST is achieved.	Staurosporine	55-68	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	48-53
29519914-3	2018	A molecular model for the catalytic OST subunit STT3A (staurosporine and temperature sensitive 3A) revealed how it is integrated into the OST and how STT3-paralog specificity for translocon-associated OST is achieved.	Staurosporine	55-68	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	138-141
29519914-3	2018	A molecular model for the catalytic OST subunit STT3A (staurosporine and temperature sensitive 3A) revealed how it is integrated into the OST and how STT3-paralog specificity for translocon-associated OST is achieved.	Staurosporine	55-68	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit	Homo sapiens	138-141
30038935-4	2018	Staurosporine increased vector copy number (VCN) approximately 2-fold when added to mobilized peripheral blood (mPB) CD34+ cells prior to transduction.	Staurosporine	0-13	CD34 molecule	Homo sapiens	117-121
30038935-9	2018	The combinatorial use of small molecules, such as staurosporine and PGE2, to enhance LVV transduction of human CD34+ cells is a promising method to improve transduction efficiency and subsequent potential therapeutic benefit of gene therapy drug products.	Staurosporine	50-63	CD34 molecule	Homo sapiens	111-115
29321664-6	2018	Here we report that knockdown of cofilin attenuates and overexpression of cofilin potentiates mitochondrial fission as well as PINK1/PARK2-dependent mitophagy induced by staurosporine (STS), etoposide (ETO), and carbonyl cyanide 3-chlorophenylhydrazone (CCCP).	Staurosporine	170-183	cofilin 1	Homo sapiens	33-40
29321664-6	2018	Here we report that knockdown of cofilin attenuates and overexpression of cofilin potentiates mitochondrial fission as well as PINK1/PARK2-dependent mitophagy induced by staurosporine (STS), etoposide (ETO), and carbonyl cyanide 3-chlorophenylhydrazone (CCCP).	Staurosporine	170-183	cofilin 1	Homo sapiens	74-81
29321664-6	2018	Here we report that knockdown of cofilin attenuates and overexpression of cofilin potentiates mitochondrial fission as well as PINK1/PARK2-dependent mitophagy induced by staurosporine (STS), etoposide (ETO), and carbonyl cyanide 3-chlorophenylhydrazone (CCCP).	Staurosporine	170-183	PTEN induced kinase 1	Homo sapiens	127-132
29321664-6	2018	Here we report that knockdown of cofilin attenuates and overexpression of cofilin potentiates mitochondrial fission as well as PINK1/PARK2-dependent mitophagy induced by staurosporine (STS), etoposide (ETO), and carbonyl cyanide 3-chlorophenylhydrazone (CCCP).	Staurosporine	170-183	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	133-138
29321664-6	2018	Here we report that knockdown of cofilin attenuates and overexpression of cofilin potentiates mitochondrial fission as well as PINK1/PARK2-dependent mitophagy induced by staurosporine (STS), etoposide (ETO), and carbonyl cyanide 3-chlorophenylhydrazone (CCCP).	Staurosporine	185-188	cofilin 1	Homo sapiens	74-81
29321664-6	2018	Here we report that knockdown of cofilin attenuates and overexpression of cofilin potentiates mitochondrial fission as well as PINK1/PARK2-dependent mitophagy induced by staurosporine (STS), etoposide (ETO), and carbonyl cyanide 3-chlorophenylhydrazone (CCCP).	Staurosporine	185-188	PTEN induced kinase 1	Homo sapiens	127-132
29321664-6	2018	Here we report that knockdown of cofilin attenuates and overexpression of cofilin potentiates mitochondrial fission as well as PINK1/PARK2-dependent mitophagy induced by staurosporine (STS), etoposide (ETO), and carbonyl cyanide 3-chlorophenylhydrazone (CCCP).	Staurosporine	185-188	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	133-138
29217661-6	2018	Activation of FoxO3 with UCN-01, a staurosporine derivative currently investigated in clinical cancer trials, reverted the IPF myofibroblast phenotype in vitro and blocked the bleomycin-induced lung fibrosis in vivo These studies implicate FoxO3 as a critical integrator of pro-fibrotic signaling in lung fibrosis and pharmacological reconstitution of FoxO3 as a novel treatment strategy.	Staurosporine	35-48	forkhead box O3	Homo sapiens	14-19
29414524-8	2018	In contrast, CREB mRNA levels exhibited a dramatic down-regulation 3 h after terminating low-Mg2+ treatment, and then peaked at 9 h. Western blot analyses verified that staurosporine suppressed CREB phosphorylation (p-CREB).	Staurosporine	169-182	cAMP responsive element binding protein 1	Rattus norvegicus	13-17
29414524-8	2018	In contrast, CREB mRNA levels exhibited a dramatic down-regulation 3 h after terminating low-Mg2+ treatment, and then peaked at 9 h. Western blot analyses verified that staurosporine suppressed CREB phosphorylation (p-CREB).	Staurosporine	169-182	cAMP responsive element binding protein 1	Rattus norvegicus	194-198
29414524-8	2018	In contrast, CREB mRNA levels exhibited a dramatic down-regulation 3 h after terminating low-Mg2+ treatment, and then peaked at 9 h. Western blot analyses verified that staurosporine suppressed CREB phosphorylation (p-CREB).	Staurosporine	169-182	cAMP responsive element binding protein 1	Rattus norvegicus	194-198
29414524-9	2018	The mRNA expression of GABAA receptor subunit alpha1 increased only in the presence of staurosporine, whereas the expressions of subunits gamma2 and delta significantly increased in the presence of either KG-501 or staurosporine.	Staurosporine	87-100	gamma-aminobutyric acid type A receptor subunit alpha 1	Rattus norvegicus	23-52
29321004-5	2018	RESULTS: Forced RCC2 expression in tumor cells blocked spontaneous- or Staurosporine (STS)-induced apoptosis.	Staurosporine	71-84	regulator of chromosome condensation 2	Homo sapiens	16-20
29321004-5	2018	RESULTS: Forced RCC2 expression in tumor cells blocked spontaneous- or Staurosporine (STS)-induced apoptosis.	Staurosporine	86-89	regulator of chromosome condensation 2	Homo sapiens	16-20
28942148-7	2017	High glucose-derived EMPs significantly increased both basal (1.5 +- 0.1 vs 1.0 +- 0.1 ng/mL) and staurosporine-stimulated (2.2 +- 0.2 vs 1.4 +- 0.1 ng/mL) active caspase-3 compared with normal glucose EMPs.	Staurosporine	98-111	caspase 3	Homo sapiens	163-172
29039468-6	2017	However, the Abeta42-induced activation of the IAPW differed from that induced by treatment with other agents, such as staurosporine (STS) in that lower amounts of cytochrome c were released from the mitochondria, the majority of procaspase-9 in the Apaf-1 complex was not processed and caspase-3 was activated to a lesser extent in the peptide-treated cells.	Staurosporine	119-132	caspase 3	Homo sapiens	287-296
29039468-6	2017	However, the Abeta42-induced activation of the IAPW differed from that induced by treatment with other agents, such as staurosporine (STS) in that lower amounts of cytochrome c were released from the mitochondria, the majority of procaspase-9 in the Apaf-1 complex was not processed and caspase-3 was activated to a lesser extent in the peptide-treated cells.	Staurosporine	134-137	cytochrome c, somatic	Homo sapiens	164-176
29039468-6	2017	However, the Abeta42-induced activation of the IAPW differed from that induced by treatment with other agents, such as staurosporine (STS) in that lower amounts of cytochrome c were released from the mitochondria, the majority of procaspase-9 in the Apaf-1 complex was not processed and caspase-3 was activated to a lesser extent in the peptide-treated cells.	Staurosporine	134-137	apoptotic peptidase activating factor 1	Homo sapiens	250-256
29039468-6	2017	However, the Abeta42-induced activation of the IAPW differed from that induced by treatment with other agents, such as staurosporine (STS) in that lower amounts of cytochrome c were released from the mitochondria, the majority of procaspase-9 in the Apaf-1 complex was not processed and caspase-3 was activated to a lesser extent in the peptide-treated cells.	Staurosporine	134-137	caspase 3	Homo sapiens	287-296
28756208-9	2017	Similar findings were observed with doxorubicin, sorafenib and staurosporine, that also promoted ROS-mediated cell death that was attenuated in MDA-2J2 cells and reversed by ALDH1A1 gene silencing.	Staurosporine	63-76	aldehyde dehydrogenase 1 family member A1	Homo sapiens	174-181
28904196-5	2017	Furthermore, ectopic M1L expression decreased staurosporine-induced (intrinsic) apoptosis in HeLa cells.	Staurosporine	46-59	ankyin-like protein	Vaccinia virus	21-24
28965654-0	2017	Broad-spectrum protein kinase inhibition by the staurosporine analog KT-5720 reverses ethanol withdrawal-associated loss of NeuN/Fox-3.	Staurosporine	48-61	RNA binding fox-1 homolog 3	Rattus norvegicus	124-128
27509531-9	2017	Antioxidant N-acetyl-cysteine (NAC) and protein tyrosine kinase (PTK) inhibitor staurosporine decreased the NHE activity in DJ-1 deficient CD4+ T cells, and blunted the difference between DJ-1-/- and DJ-1+/+ CD4+ T cells, an observation pointing to a role of ROS in the up-regulation of NHE1 in DJ-1-/- CD4+ T cells.	Staurosporine	80-93	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	124-128
29117318-0	2017	Lamin Cleavage: A Reliable Marker for Studying Staurosporine-Induced Apoptosis in Corneal Tissue.	Staurosporine	47-60	lamin A/C	Homo sapiens	0-5
27509531-9	2017	Antioxidant N-acetyl-cysteine (NAC) and protein tyrosine kinase (PTK) inhibitor staurosporine decreased the NHE activity in DJ-1 deficient CD4+ T cells, and blunted the difference between DJ-1-/- and DJ-1+/+ CD4+ T cells, an observation pointing to a role of ROS in the up-regulation of NHE1 in DJ-1-/- CD4+ T cells.	Staurosporine	80-93	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	188-192
27509531-9	2017	Antioxidant N-acetyl-cysteine (NAC) and protein tyrosine kinase (PTK) inhibitor staurosporine decreased the NHE activity in DJ-1 deficient CD4+ T cells, and blunted the difference between DJ-1-/- and DJ-1+/+ CD4+ T cells, an observation pointing to a role of ROS in the up-regulation of NHE1 in DJ-1-/- CD4+ T cells.	Staurosporine	80-93	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	188-192
27509531-9	2017	Antioxidant N-acetyl-cysteine (NAC) and protein tyrosine kinase (PTK) inhibitor staurosporine decreased the NHE activity in DJ-1 deficient CD4+ T cells, and blunted the difference between DJ-1-/- and DJ-1+/+ CD4+ T cells, an observation pointing to a role of ROS in the up-regulation of NHE1 in DJ-1-/- CD4+ T cells.	Staurosporine	80-93	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	287-291
27509531-9	2017	Antioxidant N-acetyl-cysteine (NAC) and protein tyrosine kinase (PTK) inhibitor staurosporine decreased the NHE activity in DJ-1 deficient CD4+ T cells, and blunted the difference between DJ-1-/- and DJ-1+/+ CD4+ T cells, an observation pointing to a role of ROS in the up-regulation of NHE1 in DJ-1-/- CD4+ T cells.	Staurosporine	80-93	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	188-192
28938399-5	2017	Moreover, in vitro experimental studies suggest that the protein kinase C inhibitor staurosporine (STS) causes the physical destruction of GCs by the activation of caspase-3.	Staurosporine	84-97	caspase 3	Rattus norvegicus	164-173
28938399-5	2017	Moreover, in vitro experimental studies suggest that the protein kinase C inhibitor staurosporine (STS) causes the physical destruction of GCs by the activation of caspase-3.	Staurosporine	99-102	caspase 3	Rattus norvegicus	164-173
29245928-5	2017	Myocardin and Stat3 synergistically inhibited staurosporine-induced cardiomyocyte apoptosis by up-regulating expression of anti-apoptotic Bcl-2 and Mcl-1 in neonatal rat cardiomyocytes.	Staurosporine	46-59	myocardin	Rattus norvegicus	0-9
29039468-6	2017	However, the Abeta42-induced activation of the IAPW differed from that induced by treatment with other agents, such as staurosporine (STS) in that lower amounts of cytochrome c were released from the mitochondria, the majority of procaspase-9 in the Apaf-1 complex was not processed and caspase-3 was activated to a lesser extent in the peptide-treated cells.	Staurosporine	119-132	cytochrome c, somatic	Homo sapiens	164-176
29039468-6	2017	However, the Abeta42-induced activation of the IAPW differed from that induced by treatment with other agents, such as staurosporine (STS) in that lower amounts of cytochrome c were released from the mitochondria, the majority of procaspase-9 in the Apaf-1 complex was not processed and caspase-3 was activated to a lesser extent in the peptide-treated cells.	Staurosporine	119-132	apoptotic peptidase activating factor 1	Homo sapiens	250-256
28731171-6	2017	In addition, PTF enhanced the protein expression of GPR40 and to a certain extent strengthened the protein expression of PKC, increased cellular levels of triphosphoinositide (IP3) and diacylglycerol (DAG), and promoted GW9508-stimulated activity of PLC and PKC reduced by PA in INS-1 cells, which were blocked by PLC inhibitor U-73122 and PKC inhibitor staurosporine, respectively.	Staurosporine	354-367	free fatty acid receptor 1	Rattus norvegicus	52-57
29245928-5	2017	Myocardin and Stat3 synergistically inhibited staurosporine-induced cardiomyocyte apoptosis by up-regulating expression of anti-apoptotic Bcl-2 and Mcl-1 in neonatal rat cardiomyocytes.	Staurosporine	46-59	signal transducer and activator of transcription 3	Rattus norvegicus	14-19
29245928-5	2017	Myocardin and Stat3 synergistically inhibited staurosporine-induced cardiomyocyte apoptosis by up-regulating expression of anti-apoptotic Bcl-2 and Mcl-1 in neonatal rat cardiomyocytes.	Staurosporine	46-59	BCL2, apoptosis regulator	Rattus norvegicus	138-143
29245928-5	2017	Myocardin and Stat3 synergistically inhibited staurosporine-induced cardiomyocyte apoptosis by up-regulating expression of anti-apoptotic Bcl-2 and Mcl-1 in neonatal rat cardiomyocytes.	Staurosporine	46-59	MCL1 apoptosis regulator, BCL2 family member	Rattus norvegicus	148-153
28659495-5	2017	Treatment of cells with staurosporine or the death receptor ligand FasL triggers caspase-mediated cleavage of SMSr at a conserved aspartate located downstream of the enzyme"s SAM domain and upstream of its first membrane span.	Staurosporine	24-37	sterile alpha motif domain containing 8	Homo sapiens	110-114
28787459-3	2017	Using cultured hippocampal slices and primary neurons we show that a typical apoptosis inducer-staurosporine (STP) was able to cause concentration-dependent apoptotic cell death in brain slices; Enhanced synaptic activity by bicuculline (Bic)/4-Aminopyridine (AP) treatment effectively prevented neurons from STP-induced cell apoptosis, as indicated by increased cell survival and suppressed caspase-3 activity.	Staurosporine	95-108	caspase 3	Homo sapiens	392-401
28752700-1	2017	PURPOSE: To investigate the effects of anti-vascular endothelial growth factor (VEGF) antibody on the survival of retinal ganglion cell (RGC)-5 cells differentiated with staurosporine under oxidative stress.	Staurosporine	170-183	vascular endothelial growth factor A	Mus musculus	39-78
28752700-1	2017	PURPOSE: To investigate the effects of anti-vascular endothelial growth factor (VEGF) antibody on the survival of retinal ganglion cell (RGC)-5 cells differentiated with staurosporine under oxidative stress.	Staurosporine	170-183	vascular endothelial growth factor A	Mus musculus	80-84
28752700-2	2017	METHODS: We used real-time polymerase chain reaction and Western blot to confirm the expression of VEGF, VEGF receptor (VEGFR)-1 and VEGFR-2 in RGC-5 cells differentiated with staurosporine for 6 hours.	Staurosporine	176-189	vascular endothelial growth factor A	Mus musculus	99-103
28752700-2	2017	METHODS: We used real-time polymerase chain reaction and Western blot to confirm the expression of VEGF, VEGF receptor (VEGFR)-1 and VEGFR-2 in RGC-5 cells differentiated with staurosporine for 6 hours.	Staurosporine	176-189	vascular endothelial growth factor A	Mus musculus	105-109
28752700-2	2017	METHODS: We used real-time polymerase chain reaction and Western blot to confirm the expression of VEGF, VEGF receptor (VEGFR)-1 and VEGFR-2 in RGC-5 cells differentiated with staurosporine for 6 hours.	Staurosporine	176-189	FMS-like tyrosine kinase 1	Mus musculus	120-128
28752700-2	2017	METHODS: We used real-time polymerase chain reaction and Western blot to confirm the expression of VEGF, VEGF receptor (VEGFR)-1 and VEGFR-2 in RGC-5 cells differentiated with staurosporine for 6 hours.	Staurosporine	176-189	kinase insert domain protein receptor	Mus musculus	133-140
28486557-7	2017	ANP32B knockdown by siRNA altered the expression of apoptosis-related proteins in HCC cell lines and reduced the expression of cleaved forms of caspase 3 and caspase 9, but not that of caspase 8, in HCC cells cultured with the pro-apoptotic agent staurosporine.	Staurosporine	247-260	acidic nuclear phosphoprotein 32 family member B	Homo sapiens	0-6
31966642-9	2017	Moreover, degradation of nerve fibre (NF) was markedly reduced in the STS injection group compared with the injured and PBS-injected group by inducing astrocyte expression of Bcl-2.	Staurosporine	70-73	B cell leukemia/lymphoma 2	Mus musculus	175-180
28456628-4	2017	Go6976 is a staurosporine-like reversible inhibitor targeting T790M while sparing the wild-type EGFR.	Staurosporine	12-25	epidermal growth factor receptor	Homo sapiens	96-100
28060382-4	2017	Cells with decreased PACS1 expression were refractory to cell death mediated by a variety of stimuli that operate through the mitochondrial pathway, including human granzyme B, staurosporine, ultraviolet radiation and etoposide, but remained sensitive to TRAIL receptor ligation.	Staurosporine	177-190	phosphofurin acidic cluster sorting protein 1	Homo sapiens	21-26
28542370-5	2017	Staurosporine, a selective PKC inhibitor, inhibited TLR4, MyD88 and p-p38 upregulation in the high-glucose-treated cells, indicating the involvement of PKC in high-glucose-induced TLR4 upregulation.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	27-30
28542370-5	2017	Staurosporine, a selective PKC inhibitor, inhibited TLR4, MyD88 and p-p38 upregulation in the high-glucose-treated cells, indicating the involvement of PKC in high-glucose-induced TLR4 upregulation.	Staurosporine	0-13	toll like receptor 4	Homo sapiens	52-56
28542370-5	2017	Staurosporine, a selective PKC inhibitor, inhibited TLR4, MyD88 and p-p38 upregulation in the high-glucose-treated cells, indicating the involvement of PKC in high-glucose-induced TLR4 upregulation.	Staurosporine	0-13	MYD88 innate immune signal transduction adaptor	Homo sapiens	58-63
28542370-5	2017	Staurosporine, a selective PKC inhibitor, inhibited TLR4, MyD88 and p-p38 upregulation in the high-glucose-treated cells, indicating the involvement of PKC in high-glucose-induced TLR4 upregulation.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	152-155
28542370-5	2017	Staurosporine, a selective PKC inhibitor, inhibited TLR4, MyD88 and p-p38 upregulation in the high-glucose-treated cells, indicating the involvement of PKC in high-glucose-induced TLR4 upregulation.	Staurosporine	0-13	toll like receptor 4	Homo sapiens	180-184
28596240-6	2017	However, unlike dynamin-2 and Drp1, whose depletion protects cells from staurosporine-induced mitochondrial fragmentation, EHD1-depleted cells remain sensitive to staurosporine, suggesting a different mechanism for EHD1 function.	Staurosporine	163-176	EH domain containing 1	Homo sapiens	123-127
28493974-3	2017	In this study, we identified the acute phase protein alpha-1 Antitrypsin (AAT) as a potent suppressor of staurosporine (STS)-induced apoptosis in human neutrophils through a mechanism implicating caspases-independent pathways.	Staurosporine	105-118	serpin family A member 1	Homo sapiens	53-72
28493974-3	2017	In this study, we identified the acute phase protein alpha-1 Antitrypsin (AAT) as a potent suppressor of staurosporine (STS)-induced apoptosis in human neutrophils through a mechanism implicating caspases-independent pathways.	Staurosporine	105-118	serpin family A member 1	Homo sapiens	74-77
28493974-3	2017	In this study, we identified the acute phase protein alpha-1 Antitrypsin (AAT) as a potent suppressor of staurosporine (STS)-induced apoptosis in human neutrophils through a mechanism implicating caspases-independent pathways.	Staurosporine	120-123	serpin family A member 1	Homo sapiens	53-72
28493974-3	2017	In this study, we identified the acute phase protein alpha-1 Antitrypsin (AAT) as a potent suppressor of staurosporine (STS)-induced apoptosis in human neutrophils through a mechanism implicating caspases-independent pathways.	Staurosporine	120-123	serpin family A member 1	Homo sapiens	74-77
28383560-8	2017	Increased Beclin 1 cleavage and partial nuclear translocation of Beclin 1 fragment was detected in STS-treated cells, which could be blocked by spermidine, pan-caspase inhibitor or caspase 3-specific inhibitor.	Staurosporine	99-102	beclin 1	Rattus norvegicus	10-18
28383560-8	2017	Increased Beclin 1 cleavage and partial nuclear translocation of Beclin 1 fragment was detected in STS-treated cells, which could be blocked by spermidine, pan-caspase inhibitor or caspase 3-specific inhibitor.	Staurosporine	99-102	beclin 1	Rattus norvegicus	65-73
28383560-8	2017	Increased Beclin 1 cleavage and partial nuclear translocation of Beclin 1 fragment was detected in STS-treated cells, which could be blocked by spermidine, pan-caspase inhibitor or caspase 3-specific inhibitor.	Staurosporine	99-102	caspase 3	Rattus norvegicus	181-190
27696725-2	2017	Previously, the reversible pan-kinase inhibitor staurosporine has been found to selectively inhibit the HER2 T798M mutant over wild-type kinase, suggesting that the staurosporine scaffold is potentially to develop mutant-selective inhibitors.	Staurosporine	48-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
27891677-0	2017	Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology.	Staurosporine	0-13	epidermal growth factor receptor	Homo sapiens	98-102
27891677-3	2017	Previously, the reversible pan-kinase inhibitor staurosporine and its several analogs such as Go6976 and K252a have been reported to selectively inhibit the EGFR T790M mutant (EGFRT790M ) over wild-type kinase (EGFRWT ), suggesting that the staurosporine scaffold is potentially to develop the wild-type sparing reversible inhibitors of EGFRT790M .	Staurosporine	48-61	epidermal growth factor receptor	Homo sapiens	157-161
27891677-3	2017	Previously, the reversible pan-kinase inhibitor staurosporine and its several analogs such as Go6976 and K252a have been reported to selectively inhibit the EGFR T790M mutant (EGFRT790M ) over wild-type kinase (EGFRWT ), suggesting that the staurosporine scaffold is potentially to develop the wild-type sparing reversible inhibitors of EGFRT790M .	Staurosporine	241-254	epidermal growth factor receptor	Homo sapiens	157-161
27891677-4	2017	Here, we systematically evaluated the inhibitor response of 28 staurosporine scaffold-based compounds to EGFR T790M mutation at structural, energetic, and molecular levels by using an integrated in silico-in vitro analog-sensitive (AS) kinase technology.	Staurosporine	63-76	epidermal growth factor receptor	Homo sapiens	105-109
28815246-2	2017	METHODS: Plasmid pGFP-V-RS-P120ctn shRNA was used to transfect HN4 cells to significantly reduce the expression of P120ctn and PKC inhibitor staurosporine (STS) was added.	Staurosporine	141-154	catenin delta 1	Homo sapiens	27-34
28815246-2	2017	METHODS: Plasmid pGFP-V-RS-P120ctn shRNA was used to transfect HN4 cells to significantly reduce the expression of P120ctn and PKC inhibitor staurosporine (STS) was added.	Staurosporine	141-154	MT-RNR2 like 4 (pseudogene)	Homo sapiens	63-66
28815246-2	2017	METHODS: Plasmid pGFP-V-RS-P120ctn shRNA was used to transfect HN4 cells to significantly reduce the expression of P120ctn and PKC inhibitor staurosporine (STS) was added.	Staurosporine	141-154	proline rich transmembrane protein 2	Homo sapiens	127-130
28815246-2	2017	METHODS: Plasmid pGFP-V-RS-P120ctn shRNA was used to transfect HN4 cells to significantly reduce the expression of P120ctn and PKC inhibitor staurosporine (STS) was added.	Staurosporine	156-159	catenin delta 1	Homo sapiens	27-34
28815246-2	2017	METHODS: Plasmid pGFP-V-RS-P120ctn shRNA was used to transfect HN4 cells to significantly reduce the expression of P120ctn and PKC inhibitor staurosporine (STS) was added.	Staurosporine	156-159	MT-RNR2 like 4 (pseudogene)	Homo sapiens	63-66
28815246-2	2017	METHODS: Plasmid pGFP-V-RS-P120ctn shRNA was used to transfect HN4 cells to significantly reduce the expression of P120ctn and PKC inhibitor staurosporine (STS) was added.	Staurosporine	156-159	catenin delta 1	Homo sapiens	115-122
28815246-2	2017	METHODS: Plasmid pGFP-V-RS-P120ctn shRNA was used to transfect HN4 cells to significantly reduce the expression of P120ctn and PKC inhibitor staurosporine (STS) was added.	Staurosporine	156-159	proline rich transmembrane protein 2	Homo sapiens	127-130
28292893-1	2017	Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.	Staurosporine	17-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	136-139
28292893-1	2017	Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.	Staurosporine	17-30	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	161-165
28292893-1	2017	Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) differentiation by inhibiting nuclear localization of the MYC transcription factor NME2, which in turn results in down-regulation of MYC transcription.	Staurosporine	17-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	211-214
28063999-3	2017	In this paper we used multiparameter fluorescence microscopy to analyze energy metabolism, intracellular pH and caspase-3 activation in living cancer cells in vitro during staurosporine-induced apoptosis.	Staurosporine	172-185	caspase 3	Mus musculus	112-121
28174208-5	2017	pH/Deltapsim uncoupling occurs early during staurosporine-induced apoptosis and is mitigated by OPA1 overexpression, suggesting that OPA1 maintains mitopHlash competence during stress conditions.	Staurosporine	44-57	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	133-137
27979980-12	2017	PKC inhibitors, Go6983 and staurosporine, CREB inhibitors, curcumin and naphthol AS-E, and knockdown of CREB suppressed the heat-induced increases in IL-6.	Staurosporine	27-40	interleukin 6	Mus musculus	150-154
28349827-0	2017	Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway.	Staurosporine	0-13	HtrA serine peptidase 2	Homo sapiens	68-73
28349827-0	2017	Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway.	Staurosporine	0-13	AKT serine/threonine kinase 1	Homo sapiens	102-105
28349827-7	2017	We found that staurosporine significantly decreased cell viability and increased cell apoptosis in a concentration- and time-dependent manner in HepG2 cancer cells, along with the decreased expressions of PDK1 protein and Akt phosphorylation.	Staurosporine	14-27	pyruvate dehydrogenase kinase 1	Homo sapiens	205-209
28349827-7	2017	We found that staurosporine significantly decreased cell viability and increased cell apoptosis in a concentration- and time-dependent manner in HepG2 cancer cells, along with the decreased expressions of PDK1 protein and Akt phosphorylation.	Staurosporine	14-27	AKT serine/threonine kinase 1	Homo sapiens	222-225
28349827-8	2017	Staurosporine was also found to enhance Omi/HtrA2 release from mitochondria.	Staurosporine	0-13	HtrA serine peptidase 2	Homo sapiens	44-49
28349827-10	2017	Pharmacological and genetic inhibition of Omi/HtrA2 restored protein levels of PDK1 and protected HepG2 cancer cells from staurosporine-induced cell death.	Staurosporine	122-135	HtrA serine peptidase 2	Homo sapiens	46-51
28349827-13	2017	Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects.	Staurosporine	42-55	AKT serine/threonine kinase 1	Homo sapiens	105-108
28349827-13	2017	Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects.	Staurosporine	42-55	HtrA serine peptidase 2	Homo sapiens	139-144
28349827-13	2017	Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects.	Staurosporine	42-55	pyruvate dehydrogenase kinase 1	Homo sapiens	154-158
28349827-13	2017	Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects.	Staurosporine	224-237	AKT serine/threonine kinase 1	Homo sapiens	105-108
28349827-13	2017	Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects.	Staurosporine	224-237	HtrA serine peptidase 2	Homo sapiens	139-144
28349827-13	2017	Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects.	Staurosporine	224-237	pyruvate dehydrogenase kinase 1	Homo sapiens	154-158
28178656-0	2017	Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.	Staurosporine	63-76	AKT serine/threonine kinase 1	Homo sapiens	126-129
28178656-8	2017	It was further revealed that high Stathmin expression was associated with the repression of staurosporine-induced apoptosis in the cholangiocarcinoma cell.	Staurosporine	92-105	stathmin 1	Homo sapiens	34-42
27835826-7	2017	Hypoxia-stimulated HIF1alpha and 18F-FDG accumulation was blocked by the protein kinase C (PKC) inhibitor, staurosporine.	Staurosporine	107-120	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-28
28102851-2	2017	Yet, detrimental effects of elevated PrPc levels under stress conditions, such as exposure to staurosporine (STS) have also been described.	Staurosporine	94-107	prion protein	Homo sapiens	37-41
28102851-2	2017	Yet, detrimental effects of elevated PrPc levels under stress conditions, such as exposure to staurosporine (STS) have also been described.	Staurosporine	109-112	prion protein	Homo sapiens	37-41
28222420-8	2017	The effect of Camalexin on annexin-V-binding was significantly blunted by removal of extracellular Ca2+, by kinase inhibitors staurosporine (1 microM) and chelerythrine (10 microM), as well as by caspase inhibitors zVAD (10 microM) and zIETD-fmk (50 microM).	Staurosporine	126-139	annexin A5	Homo sapiens	27-36
28793293-12	2017	The effect of temsirolimus on annexin-V-binding was significantly blunted but not abolished by removal of extracellular Ca2+ and by addition of staurosporine (1 microM) or chelerythrine (10 microM) but not significantly modified by addition of SB203580 (2 microM), D4476 (10 microM), or zVAD (10 microM).	Staurosporine	144-157	annexin A5	Homo sapiens	30-39
28220405-7	2017	Also, Idua-/- fibroblasts were more resistant to the apoptotic induction with staurosporine, indicating a possible resistance to apoptotic induction in those cells.	Staurosporine	78-91	iduronidase, alpha-L	Mus musculus	6-10
27577743-5	2017	Overexpression of SIRT5 markedly protected SH-EP cells from apoptosis induced by staurosporine or by incubation in Hank"s balanced salt solution.	Staurosporine	81-94	sirtuin 5	Homo sapiens	18-23
28367274-0	2017	Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons.	Staurosporine	60-73	AKT serine/threonine kinase 1	Homo sapiens	85-88
28367274-0	2017	Reactive Oxygen Species Evoked by Potassium Deprivation and Staurosporine Inactivate Akt and Induce the Expression of TXNIP in Cerebellar Granule Neurons.	Staurosporine	60-73	thioredoxin interacting protein	Homo sapiens	118-123
28188805-8	2017	Moreover, the pro-survival effect of FGF2 from apoptotic cell death induced by staurosporine treatment was dependent on SK but not on S1PR.	Staurosporine	79-92	fibroblast growth factor 2	Mus musculus	37-41
28131630-11	2017	When RyR2 phosphorylation at serine-2809 was reduced to its "basal" level (i.e. RyR2 phosphorylation level in intact myocytes) using kinase inhibitor staurosporine, SR Ca2+ leak was significantly reduced.	Staurosporine	150-163	ryanodine receptor 2	Oryctolagus cuniculus	5-9
28165468-4	2017	Addition of rhFasL and staurosporine, well-known apoptosis inducers, caused significantly increased cleaved caspase-3, -8, and PARP in Thy-1-transfected cells.	Staurosporine	23-36	poly (ADP-ribose) polymerase family, member 1	Mus musculus	127-131
28165468-4	2017	Addition of rhFasL and staurosporine, well-known apoptosis inducers, caused significantly increased cleaved caspase-3, -8, and PARP in Thy-1-transfected cells.	Staurosporine	23-36	thymus cell antigen 1, theta	Mus musculus	135-140
28178656-0	2017	Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.	Staurosporine	63-76	stathmin 1	Homo sapiens	0-8
28178656-0	2017	Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling.	Staurosporine	63-76	mitogen-activated protein kinase 1	Homo sapiens	118-121
28191975-3	2017	Isomicromonolactam (1), staurosporin (2), and linarin (3) were isolated as Hes1-binding compounds using the TPO-NAPI method.	Staurosporine	24-36	hes family bHLH transcription factor 1	Homo sapiens	75-79
28197073-8	2017	Interestingly, several agents that induce cell death [amyloid beta (Abeta)-peptide, staurosporine and rapamycin], albeit via different mechanisms, all caused dissociation of APP/TrkA complexes and increased production of C-terminal fragment (beta-CTF) APP fragment.	Staurosporine	84-97	neurotrophic receptor tyrosine kinase 1	Homo sapiens	178-182
28212798-10	2017	First-generation PKC inhibitors such as staurosporine and chelerythrine are not very specific.	Staurosporine	40-53	proline rich transmembrane protein 2	Homo sapiens	17-20
28127981-9	2017	RESULTS: Our results showed that BM soup administration for 48 hours protectsed against 1muM staurosporine concentration induced cell death and reduced cell toxicity in MCF-7 and AGS cells.	Staurosporine	93-106	latexin	Homo sapiens	89-92
28472790-13	2017	The effect of perifosine on annexin-V-binding was significantly blunted by removal of extracellular Ca2+ and by addition of staurosporine (1 microM), but not by addition of SB203580 (2 microM).	Staurosporine	124-137	annexin A5	Homo sapiens	28-37
27693639-6	2016	Knockdown of FAT1 and CASP8 individually or in combination in OSCC cells led to increased cell migration and clonal growth, resistance to Staurosporine-induced apoptosis and, in some cases, increased terminal differentiation.	Staurosporine	138-151	FAT atypical cadherin 1	Homo sapiens	13-17
27693639-6	2016	Knockdown of FAT1 and CASP8 individually or in combination in OSCC cells led to increased cell migration and clonal growth, resistance to Staurosporine-induced apoptosis and, in some cases, increased terminal differentiation.	Staurosporine	138-151	caspase 8	Homo sapiens	22-27
27783407-8	2016	The use of PKCdelta inhibitor candidates, including Go6983, bisindolylmaleimide II, staurosporine, and rottlerin in the assay resulted in IC50 values of 50 nM, 15 nM, 795 nM, and 4 muM, respectively.	Staurosporine	84-97	protein kinase C delta	Homo sapiens	11-19
27769857-0	2016	Staurosporine as an agonist for induction of GLUT4 translocation, identified by a pH-sensitive fluorescent IRAP-mOrange2 probe.	Staurosporine	0-13	solute carrier family 2 member 4	Homo sapiens	45-50
27769857-0	2016	Staurosporine as an agonist for induction of GLUT4 translocation, identified by a pH-sensitive fluorescent IRAP-mOrange2 probe.	Staurosporine	0-13	leucyl and cystinyl aminopeptidase	Homo sapiens	107-111
27769857-6	2016	Our work highlights the convenience and efficiency of this novel pH-sensitive fluorescent probe and reveals the new biological activity of staurosporine as an agonist for GLUT4 translocation and as an effective insulin additive analogue.	Staurosporine	139-152	solute carrier family 2 member 4	Homo sapiens	171-176
27681840-8	2016	Among kinase inhibitors that affected DMT1-mediated iron uptake, staurosporine also reduced DMT1 phosphorylation confirming a role for serine phosphorylation in iron transport regulation.	Staurosporine	65-78	solute carrier family 11 member 2	Homo sapiens	38-42
27681840-8	2016	Among kinase inhibitors that affected DMT1-mediated iron uptake, staurosporine also reduced DMT1 phosphorylation confirming a role for serine phosphorylation in iron transport regulation.	Staurosporine	65-78	solute carrier family 11 member 2	Homo sapiens	92-96
27696725-2	2017	Previously, the reversible pan-kinase inhibitor staurosporine has been found to selectively inhibit the HER2 T798M mutant over wild-type kinase, suggesting that the staurosporine scaffold is potentially to develop mutant-selective inhibitors.	Staurosporine	165-178	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
27696725-3	2017	Here, we systematically evaluated the chemical space of staurosporine scaffold-based compounds in response to HER2 T798M mutation at structural, energetic and molecular levels by using an integrated analysis strategy.	Staurosporine	56-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	110-114
27665842-0	2016	Staurosporine enhances ATRA-induced granulocytic differentiation in human leukemia U937 cells via the MEK/ERK signaling pathway.	Staurosporine	0-13	mitogen-activated protein kinase 1	Homo sapiens	106-109
27665842-0	2016	Staurosporine enhances ATRA-induced granulocytic differentiation in human leukemia U937 cells via the MEK/ERK signaling pathway.	Staurosporine	0-13	mitogen-activated protein kinase kinase 7	Homo sapiens	102-105
27539959-4	2016	In human colon cancer cells, forced overexpression of Eomes enhanced cell viability and protected against staurosporine-induced apoptosis.	Staurosporine	106-119	eomesodermin	Homo sapiens	54-59
27724921-6	2016	RESULTS: Both the disruption of claudin-4 activity and the loss of claudin-4 expression significantly increased tumor cell caspase-3 activation (4 to 10-fold, respectively) in response to the apoptotic inducer staurosporine and reduced tumor cell migration by 50 %.	Staurosporine	210-223	claudin 4	Mus musculus	32-41
27724921-6	2016	RESULTS: Both the disruption of claudin-4 activity and the loss of claudin-4 expression significantly increased tumor cell caspase-3 activation (4 to 10-fold, respectively) in response to the apoptotic inducer staurosporine and reduced tumor cell migration by 50 %.	Staurosporine	210-223	claudin 4	Mus musculus	67-76
27724921-6	2016	RESULTS: Both the disruption of claudin-4 activity and the loss of claudin-4 expression significantly increased tumor cell caspase-3 activation (4 to 10-fold, respectively) in response to the apoptotic inducer staurosporine and reduced tumor cell migration by 50 %.	Staurosporine	210-223	caspase 3	Mus musculus	123-132
26987391-12	2016	Treatment with PKC inhibitor staurosporine resulted in ameliorated TRIM29 induced activation of NF-kappaB.	Staurosporine	29-42	proline rich transmembrane protein 2	Homo sapiens	15-18
26987391-12	2016	Treatment with PKC inhibitor staurosporine resulted in ameliorated TRIM29 induced activation of NF-kappaB.	Staurosporine	29-42	tripartite motif containing 29	Homo sapiens	67-73
26987391-12	2016	Treatment with PKC inhibitor staurosporine resulted in ameliorated TRIM29 induced activation of NF-kappaB.	Staurosporine	29-42	nuclear factor kappa B subunit 1	Homo sapiens	96-105
27655287-6	2016	Overexpression of gamma-synuclein in H157 cells enhances cell proliferation and protects the cells from staurosporine-induced cytotoxicity.	Staurosporine	104-117	synuclein gamma	Homo sapiens	18-33
27755539-5	2016	Intrathecal application of PAR2 activating peptide SLIGKV-NH2 induced thermal hyperalgesia, which was prevented by pretreatment with TRPV1 antagonist SB 366791 and was reduced by protein kinases inhibitor staurosporine.	Staurosporine	205-218	F2R like trypsin receptor 1	Rattus norvegicus	27-31
27755539-5	2016	Intrathecal application of PAR2 activating peptide SLIGKV-NH2 induced thermal hyperalgesia, which was prevented by pretreatment with TRPV1 antagonist SB 366791 and was reduced by protein kinases inhibitor staurosporine.	Staurosporine	205-218	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	133-138
27755539-7	2016	All these EPSC changes, induced by PAR2 activation, were prevented by SB 366791 and staurosporine pretreatment.	Staurosporine	84-97	F2R like trypsin receptor 1	Rattus norvegicus	35-39
27439606-0	2016	Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells.	Staurosporine	43-56	H4 clustered histone 9	Homo sapiens	0-10
27439606-0	2016	Histone H4 is cleaved by granzyme A during staurosporine-induced cell death in B-lymphoid Raji cells.	Staurosporine	43-56	granzyme A	Homo sapiens	25-35
27439606-4	2016	Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced cell death; however, in the presence of caspase inhibitors, staurosporine-treated Raji cells underwent necroptosis instead of apoptosis.	Staurosporine	65-78	H4 clustered histone 9	Homo sapiens	27-37
27439606-4	2016	Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced cell death; however, in the presence of caspase inhibitors, staurosporine-treated Raji cells underwent necroptosis instead of apoptosis.	Staurosporine	65-78	granzyme A	Homo sapiens	53-57
27439606-4	2016	Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced cell death; however, in the presence of caspase inhibitors, staurosporine-treated Raji cells underwent necroptosis instead of apoptosis.	Staurosporine	147-160	H4 clustered histone 9	Homo sapiens	27-37
27439606-4	2016	Here, we demonstrated that histone H4 was cleaved by GzmA during staurosporine-induced cell death; however, in the presence of caspase inhibitors, staurosporine-treated Raji cells underwent necroptosis instead of apoptosis.	Staurosporine	147-160	granzyme A	Homo sapiens	53-57
27439606-6	2016	These results suggest that histone H4 is a novel substrate for GzmA in staurosporine-induced cells.	Staurosporine	71-84	H4 clustered histone 9	Homo sapiens	27-37
27439606-6	2016	These results suggest that histone H4 is a novel substrate for GzmA in staurosporine-induced cells.	Staurosporine	71-84	granzyme A	Homo sapiens	63-67
27665842-7	2016	Staurosporine activated mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	0-13	mitogen-activated protein kinase kinase 7	Homo sapiens	24-63
27665842-7	2016	Staurosporine activated mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	0-13	mitogen-activated protein kinase kinase 7	Homo sapiens	65-68
27665842-7	2016	Staurosporine activated mitogen-activated protein kinase kinase (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	0-13	mitogen-activated protein kinase 1	Homo sapiens	113-116
27665842-8	2016	Meanwhile, staurosporine also enhanced ATRA-promoted upregulation of the protein level of CCAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPepsilon in U937 cells.	Staurosporine	11-24	CCAAT enhancer binding protein beta	Homo sapiens	90-125
27665842-8	2016	Meanwhile, staurosporine also enhanced ATRA-promoted upregulation of the protein level of CCAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPepsilon in U937 cells.	Staurosporine	11-24	CCAAT enhancer binding protein beta	Homo sapiens	127-143
27665842-9	2016	Furthermore, blockade of MEK activation suppressed staurosporine-enhanced differentiation as well as the elevated protein level of C/EBPs.	Staurosporine	51-64	mitogen-activated protein kinase kinase 7	Homo sapiens	25-28
27665842-10	2016	Taken together, we concluded that staurosporine enhanced ATRA-induced granulocytic differentiation in U937 cells via MEK/ERK-mediated modulation of the protein level of C/EBPs.	Staurosporine	34-47	mitogen-activated protein kinase kinase 7	Homo sapiens	117-120
27665842-10	2016	Taken together, we concluded that staurosporine enhanced ATRA-induced granulocytic differentiation in U937 cells via MEK/ERK-mediated modulation of the protein level of C/EBPs.	Staurosporine	34-47	mitogen-activated protein kinase 1	Homo sapiens	121-124
27237977-7	2016	Calmodulin antagonism (W7) and reduction in Ca(2+) (EGTA) combined with low concentration of staurosporine caused a larger decrease in RLC phosphorylation than staurosporine alone.	Staurosporine	160-173	calmodulin 1	Rattus norvegicus	0-10
27021413-0	2016	Staurosporine allows dystrophin expression by skipping of nonsense-encoding exon.	Staurosporine	0-13	dystrophin	Homo sapiens	21-31
27021413-4	2016	PURPOSE: Staurosporine (STS), a small chemical broad kinase inhibitor, was examined for enhanced skipping of a nonsense-encoding dystrophin exon.	Staurosporine	9-22	dystrophin	Homo sapiens	129-139
27021413-4	2016	PURPOSE: Staurosporine (STS), a small chemical broad kinase inhibitor, was examined for enhanced skipping of a nonsense-encoding dystrophin exon.	Staurosporine	24-27	dystrophin	Homo sapiens	129-139
27494888-4	2016	In contrast, the deletion of the C-terminus, containing the trans-membrane domain, which is only present in Bcl-2alpha, but not in Bcl-2beta, led to impaired inhibition of IP3R-mediated Ca2+ release and staurosporine-induced apoptosis.	Staurosporine	203-216	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	172-176
27800514-4	2016	Furthermore, EPO protected bovine aortic endothelial cells from staurosporine-induced apoptosis under hypoxic conditions.	Staurosporine	64-77	erythropoietin	Bos taurus	13-16
26997499-3	2016	While Bax, Bak double deficient (DKO) and Apaf1(-/-) mouse embryonic fibroblasts (MEFs) were less susceptible to apoptosis by Bcl-2 family member BID, H(2)O(2), staurosporine and thapsigargin, Drp1(-/-) MEFs were protected only from BID and H(2)O(2).	Staurosporine	161-174	BCL2-antagonist/killer 1	Mus musculus	11-14
27358402-5	2016	PREX1 overexpression reduced staurosporine-induced apoptosis whereas its shRNA knockdown promoted apoptosis in response to staurosporine or the anti-estrogen drug tamoxifen.	Staurosporine	29-42	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	Homo sapiens	0-5
26997499-3	2016	While Bax, Bak double deficient (DKO) and Apaf1(-/-) mouse embryonic fibroblasts (MEFs) were less susceptible to apoptosis by Bcl-2 family member BID, H(2)O(2), staurosporine and thapsigargin, Drp1(-/-) MEFs were protected only from BID and H(2)O(2).	Staurosporine	161-174	apoptotic peptidase activating factor 1	Mus musculus	42-47
26490536-4	2016	METHODS: Bax siRNA was transfected into a sinusoidal endothelial cell line (M1) to suppress apoptosis induced by an anti-Fas antibody and staurosporine.	Staurosporine	138-151	BCL2-associated X protein	Mus musculus	9-12
26830332-5	2016	Here, we describe non-T cell activation linker proteolytic cleavage triggered in human B cells and monocytes by Fas cross-linking and staurosporine treatment.	Staurosporine	134-147	linker for activation of T cells family member 2	Homo sapiens	18-46
27286453-5	2016	Nonetheless, broad-spectrum inhibition by the staurosporin derivative UCN-01 blocks CRC-SC growth and potentiates the activity of irinotecan in vitro and in vivo CRC-SC-derived models.	Staurosporine	46-58	urocortin	Homo sapiens	70-73
27171685-7	2016	Finally, in vitro, quantification of the amount of cell surface-expressed SERT molecules revealed that R-citalopram prevented escitalopram-induced SERT internalization that was completely altered by staurosporine.	Staurosporine	199-212	solute carrier family 6 member 4	Rattus norvegicus	74-78
27171685-7	2016	Finally, in vitro, quantification of the amount of cell surface-expressed SERT molecules revealed that R-citalopram prevented escitalopram-induced SERT internalization that was completely altered by staurosporine.	Staurosporine	199-212	solute carrier family 6 member 4	Rattus norvegicus	147-151
26537870-10	2016	Two years after our first assessment, CIN was observed in 20% of the women in group C. The in vitro application of either a histone deacetylase inhibitor (trichostatin) or a protein kinase inhibitor (staurosporine) was found to restore lamin A/C expression in cervical cancer-derived cells.	Staurosporine	200-213	lamin A/C	Homo sapiens	236-245
26963176-5	2016	WGMBs are functionalized with antibodies for the specific and label-free detection of procaspase-3 released from human embryonic kidney HEK293 and neuroglioma H4 cells after introducing staurosporine and rotenone toxins, respectively.	Staurosporine	186-199	caspase 3	Homo sapiens	86-98
27098698-3	2016	On the contrary, we found that bok-deficient neurons were more sensitive to oxygen/glucose deprivation-induced injury in vitro and seizure-induced neuronal injury in vivo Deletion of bok also increased staurosporine-, excitotoxicity-, and oxygen/glucose deprivation-induced cell death in bax-deficient neurons.	Staurosporine	202-215	BCL2-related ovarian killer	Mus musculus	31-34
27098698-3	2016	On the contrary, we found that bok-deficient neurons were more sensitive to oxygen/glucose deprivation-induced injury in vitro and seizure-induced neuronal injury in vivo Deletion of bok also increased staurosporine-, excitotoxicity-, and oxygen/glucose deprivation-induced cell death in bax-deficient neurons.	Staurosporine	202-215	BCL2-related ovarian killer	Mus musculus	183-186
26775663-10	2016	Functionally, ginkgolide B dose-dependently attenuated doxorubicin- or staurosporine-induced apoptosis, which was reversed by transfection with PXR siRNA.	Staurosporine	71-84	nuclear receptor subfamily 1 group I member 2	Homo sapiens	144-147
26280658-7	2016	The up-regulation of annexin-V-binding after nonactin treatment was significantly blunted but not abolished by the removal of extracellular Ca(2+) and by addition of either PKC inhibitor staurosporine (0.4 muM) or p38 kinase inhibitor SB203580 (2 muM).	Staurosporine	187-200	annexin A5	Homo sapiens	21-30
26872904-9	2016	Increased tumor cell (TC)-HUVEC adhesion, as well as ICAM-1 and VCAM-1 expression induced by BD-HDL, could be inhibited by staurosporine and PKC siRNA.	Staurosporine	123-136	intercellular adhesion molecule 1	Homo sapiens	53-59
26872904-9	2016	Increased tumor cell (TC)-HUVEC adhesion, as well as ICAM-1 and VCAM-1 expression induced by BD-HDL, could be inhibited by staurosporine and PKC siRNA.	Staurosporine	123-136	vascular cell adhesion molecule 1	Homo sapiens	64-70
26711783-4	2016	Downregulated CA8 sensitized cells to apoptotic stress induced by staurosporine and cisplatin, suggesting a specific role of CA8 to protect cells from stresses.	Staurosporine	66-79	carbonic anhydrase 8	Homo sapiens	14-17
26711783-4	2016	Downregulated CA8 sensitized cells to apoptotic stress induced by staurosporine and cisplatin, suggesting a specific role of CA8 to protect cells from stresses.	Staurosporine	66-79	carbonic anhydrase 8	Homo sapiens	125-128
26777341-8	2016	The broad spectrum kinase inhibitor staurosporine was a potent inhibitor of rec.hTSSK2 (IC50 = 20 nM).	Staurosporine	36-49	testis specific serine kinase 2	Homo sapiens	80-86
27551516-3	2016	Here, we characterized how mTORC1 responds to cell death induced by various anticancer drugs such rapamycin, etoposide, cisplatin, curcumin, staurosporine and Fas ligand.	Staurosporine	141-154	CREB regulated transcription coactivator 1	Mus musculus	27-33
26944112-2	2016	We previously showed that ACTH 1-39, a melanocortin, protects OL in mixed glial cultures and enriched OL cultures, inhibiting OL death induced by staurosporine, ionotropic glutamate receptors, quinolinic acid or reactive oxygen species (ROS), but not nitric oxide (NO) or kynurenic acid.	Staurosporine	146-159	proopiomelanocortin	Homo sapiens	26-30
26743816-10	2016	Pre-treatment of the osteoblasts with staurosporine prevented the increase in CCN2 expression by induced by LPA, and the activation of PKC by phorbol 12-myristate 13-acetate (PMA) enhanced CCN2 expression, indicating that the PKC pathway is involved in the LPA-induced increase in CCN2 expression.	Staurosporine	38-51	cellular communication network factor 2	Mus musculus	78-82
25407931-5	2016	Here, we show that elevated levels of miR-126 increase neuronal vulnerability to ubiquitous toxicity mediated by staurosporine (STS) or Alzheimer"s disease (AD)-associated amyloid beta 1-42 peptides (Abeta1-42).	Staurosporine	113-126	microRNA 126a	Mus musculus	38-45
26310832-0	2016	Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation.	Staurosporine	0-13	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	123-128
26310832-4	2016	Whereas extrinsic apoptosis induction by the activation of Fas death receptor on inflammatory neutrophils was accompanied by caspase- and proteasome-mediated myeloid cell leukemia 1 degradation, intrinsic apoptosis induction by staurosporine led to a significant stabilization of myeloid cell leukemia 1 protein, which impeded on truncated forms of B cell lymphoma 2-associated X protein and B cell lymphoma 2 homology domain 3-interacting domain death translocation and subsequent cytochrome c release from the mitochondria.	Staurosporine	228-241	cytochrome c, somatic	Homo sapiens	482-494
26934461-4	2016	An established protocol that integrated bioinformatics modeling and kinase inhibition assay was employed to examine the structural basis, energetic property, and biological implication underlying the intermolecular interaction between HER2 kinase domain and three representative TKIs, i.e. two FDA-approved drugs lapatinib and gefitinib as well as a pan-kinase inhibitor staurosporine.	Staurosporine	371-384	erb-b2 receptor tyrosine kinase 2	Homo sapiens	235-239
27889774-8	2016	The effect of NSC-95397 (5 microM) on annexin-V-binding was slightly, but significantly blunted by removal of extracellular Ca2+ and by addition of the protein kinase C inhibitor staurosporine (1 microM).	Staurosporine	179-192	annexin A5	Homo sapiens	38-47
26962870-7	2016	The effect of Manumycin A on annexin-V-binding was significantly blunted by removal of extracellular Ca2+, by addition of staurosporine (1 microM) and by addition of SB203580 (2 microM).	Staurosporine	122-135	annexin A5	Homo sapiens	29-38
26427712-8	2016	In addition, inhibition of Smad3 blocked staurosporine-induced chondrogenesis.	Staurosporine	41-54	SMAD family member 3	Gallus gallus	27-32
26427712-9	2016	Inhibition of Akt, p38 mitogen-activated protein kinase (MAPK), and c-jun N-terminal kinase (JNK) suppressed chondrogenesis induced by staurosporine.	Staurosporine	135-148	adapter molecule crk	Gallus gallus	19-22
26427712-10	2016	Phosphorylation of Akt, p38 MAPK, and JNK was increased by staurosporine.	Staurosporine	59-72	adapter molecule crk	Gallus gallus	24-27
26427712-14	2016	Taken together, these results suggest that staurosporine induces chondrogenesis through TGF-beta pathways including canonical Smads and non-canonical Akt and p38 MAPK signaling.	Staurosporine	43-56	adapter molecule crk	Gallus gallus	158-161
26574931-11	2016	Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation.	Staurosporine	110-123	annexin A5	Mus musculus	12-21
26574931-11	2016	Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation.	Staurosporine	110-123	microRNA 155	Mus musculus	165-172
26574931-11	2016	Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation.	Staurosporine	110-123	caspase 3	Mus musculus	200-206
26574931-11	2016	Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation.	Staurosporine	125-128	annexin A5	Mus musculus	12-21
26574931-11	2016	Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation.	Staurosporine	125-128	microRNA 155	Mus musculus	165-172
26574931-11	2016	Strikingly, Annexin V staining of macrophages transfected with antagomir-155 and stimulated with LPS prior to staurosporine (SSP) treatment implied that LPS-induced miR-155 prevents apoptosis through CASP-3 mRNA down-regulation.	Staurosporine	125-128	caspase 3	Mus musculus	200-206
26398575-7	2015	The activation of NFAT by InB was largely suppressed by preincubation with protein kinase C (PKC) inhibitors such as staurosporine and K252a.	Staurosporine	117-130	protein kinase C alpha	Homo sapiens	93-96
26438213-2	2015	Herein, we report the first crystal structures of the cytoplasmic portion of a human phosphorylated IRE1alpha dimer in complex with (R)-2-(3,4-dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro(4.5)decane-7-carboxamide, a novel, IRE1alpha-selective kinase inhibitor, and staurosporine, a broad spectrum kinase inhibitor.	Staurosporine	270-283	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	100-109
26438213-6	2015	In contrast, staurosporine binds at the ATP-binding site of IRE1alpha, resulting in a dimer consistent with RNase active yeast Ire1 dimers.	Staurosporine	13-26	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	60-69
26438213-6	2015	In contrast, staurosporine binds at the ATP-binding site of IRE1alpha, resulting in a dimer consistent with RNase active yeast Ire1 dimers.	Staurosporine	13-26	bifunctional endoribonuclease/protein kinase IRE1	Saccharomyces cerevisiae S288C	127-131
29861926-5	2015	A probe decorated with an alkylphosphonium group was employed for the detection of mitochondrial Mg2+ in live HeLa cells, providing the first direct observation of an increase in free Mg2+ levels in this organelle in the early stages of Staurosporine-induced apoptosis.	Staurosporine	237-250	mucin 7, secreted	Homo sapiens	97-100
29861926-5	2015	A probe decorated with an alkylphosphonium group was employed for the detection of mitochondrial Mg2+ in live HeLa cells, providing the first direct observation of an increase in free Mg2+ levels in this organelle in the early stages of Staurosporine-induced apoptosis.	Staurosporine	237-250	mucin 7, secreted	Homo sapiens	184-187
26492131-6	2015	Feeding with the protein kinase inhibitor staurosporine strongly retarded the AOX1 transcription.	Staurosporine	42-55	uncharacterized protein	Chlamydomonas reinhardtii	78-82
26226001-6	2015	The up-regulation of annexin-V-binding following cantharidin treatment was not significantly blunted by removal of extracellular Ca2+ but was abolished by kinase inhibitor staurosporine (1 mM) and slightly decreased by p38 inhibitor skepinone (2 mM).	Staurosporine	172-185	annexin A5	Homo sapiens	21-30
26493876-5	2015	HeLa cells electroporated with S1 -P1 are able to deliver the cargo in the presence of staurosporin (STS), which induces apoptosis with the consequent activation of the cytoplasmic C3 enzyme.	Staurosporine	87-99	caspase 3	Homo sapiens	181-183
26493876-5	2015	HeLa cells electroporated with S1 -P1 are able to deliver the cargo in the presence of staurosporin (STS), which induces apoptosis with the consequent activation of the cytoplasmic C3 enzyme.	Staurosporine	101-104	caspase 3	Homo sapiens	181-183
27551467-5	2015	Here, we show that caspase activity induced by 4 h incubation with staurosporine was inhibited by DIDS in HeLa cells that were maintained in the absence of serum for 24 h. Interestingly, the caspase-inhibitory effect of DIDS is downstream to the inhibition of cytochrome c release, suggesting that DIDS might be also acting at the apoptosome.	Staurosporine	67-80	cytochrome c, somatic	Homo sapiens	260-272
25998538-6	2015	Extracellular alphaA/alphaB-crystallin protected astrocytes from staurosporine- and C2-ceramide-induced cell death.	Staurosporine	65-78	crystallin, alpha B	Rattus norvegicus	21-38
25998538-8	2015	Furthermore, alphaB-crystallin/HSPB5 decreases the staurosporine-mediated cleavage of caspase 3 through PI3K/Akt signaling preventing apoptosis of astrocytes.	Staurosporine	51-64	crystallin, alpha B	Rattus norvegicus	13-30
25998538-8	2015	Furthermore, alphaB-crystallin/HSPB5 decreases the staurosporine-mediated cleavage of caspase 3 through PI3K/Akt signaling preventing apoptosis of astrocytes.	Staurosporine	51-64	crystallin alpha B	Homo sapiens	31-36
25998538-8	2015	Furthermore, alphaB-crystallin/HSPB5 decreases the staurosporine-mediated cleavage of caspase 3 through PI3K/Akt signaling preventing apoptosis of astrocytes.	Staurosporine	51-64	caspase 3	Homo sapiens	86-95
25998538-8	2015	Furthermore, alphaB-crystallin/HSPB5 decreases the staurosporine-mediated cleavage of caspase 3 through PI3K/Akt signaling preventing apoptosis of astrocytes.	Staurosporine	51-64	AKT serine/threonine kinase 1	Homo sapiens	109-112
26370177-2	2015	Our in-silico studies reveal that MCP followed the similar pattern of binding as staurosporine and AG-879 (known inhibitors of TrkA) with TrkA protein (PDB ID: 4AOJ) at the ATP binding sites.	Staurosporine	81-94	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	127-131
26370177-2	2015	Our in-silico studies reveal that MCP followed the similar pattern of binding as staurosporine and AG-879 (known inhibitors of TrkA) with TrkA protein (PDB ID: 4AOJ) at the ATP binding sites.	Staurosporine	81-94	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	138-142
26366732-5	2015	Overexpressing TIMP-1 in a lung adenocarcinoma cell line H2009 resulted in an approximately 3-fold increased expression of Bcl-2, with a marked reduction in apoptosis upon staurosporine treatment.	Staurosporine	172-185	TIMP metallopeptidase inhibitor 1	Homo sapiens	15-21
26134559-7	2015	Importantly, mitochondrial XIAP actions are activated cell-intrinsically by typical apoptosis inducers TNF and staurosporine, and XIAP overexpression reduces the lag time between the administration of an apoptotic stimuli and the onset of mitochondrial permeabilization.	Staurosporine	111-124	X-linked inhibitor of apoptosis	Homo sapiens	27-31
27551448-10	2015	In fact, treatment of MLP-silenced C2C12 myoblasts and myotubes with staurosporine resulted in increased caspase-3 and PARP cleavage as well as increased percentage of cell death.	Staurosporine	69-82	cysteine and glycine-rich protein 3	Mus musculus	22-25
27551448-10	2015	In fact, treatment of MLP-silenced C2C12 myoblasts and myotubes with staurosporine resulted in increased caspase-3 and PARP cleavage as well as increased percentage of cell death.	Staurosporine	69-82	caspase 3	Mus musculus	105-114
27551448-10	2015	In fact, treatment of MLP-silenced C2C12 myoblasts and myotubes with staurosporine resulted in increased caspase-3 and PARP cleavage as well as increased percentage of cell death.	Staurosporine	69-82	poly (ADP-ribose) polymerase family, member 1	Mus musculus	119-123
26071181-3	2015	Stable overexpression of wild-type CD97 reduced serum starvation- and staurosporine-induced intrinsic and tumor necrosis factor (TNF)/cycloheximide-induced extrinsic apoptosis, indicated by an increase in cell viability, a lower percentage of cells within the subG0/G1 phase, expressing annexin V, or having condensed nuclei, and a reduction of DNA laddering.	Staurosporine	70-83	adhesion G protein-coupled receptor E5	Homo sapiens	35-39
26071181-3	2015	Stable overexpression of wild-type CD97 reduced serum starvation- and staurosporine-induced intrinsic and tumor necrosis factor (TNF)/cycloheximide-induced extrinsic apoptosis, indicated by an increase in cell viability, a lower percentage of cells within the subG0/G1 phase, expressing annexin V, or having condensed nuclei, and a reduction of DNA laddering.	Staurosporine	70-83	tumor necrosis factor	Homo sapiens	106-127
26071181-3	2015	Stable overexpression of wild-type CD97 reduced serum starvation- and staurosporine-induced intrinsic and tumor necrosis factor (TNF)/cycloheximide-induced extrinsic apoptosis, indicated by an increase in cell viability, a lower percentage of cells within the subG0/G1 phase, expressing annexin V, or having condensed nuclei, and a reduction of DNA laddering.	Staurosporine	70-83	tumor necrosis factor	Homo sapiens	129-132
26071181-3	2015	Stable overexpression of wild-type CD97 reduced serum starvation- and staurosporine-induced intrinsic and tumor necrosis factor (TNF)/cycloheximide-induced extrinsic apoptosis, indicated by an increase in cell viability, a lower percentage of cells within the subG0/G1 phase, expressing annexin V, or having condensed nuclei, and a reduction of DNA laddering.	Staurosporine	70-83	annexin A5	Homo sapiens	287-296
26218761-11	2015	A PKC inhibitor, staurosporine, was used to inhibit PKC activity in CTRP3 treated RWPE-1 cells.	Staurosporine	17-30	proline rich transmembrane protein 2	Homo sapiens	2-5
26218761-11	2015	A PKC inhibitor, staurosporine, was used to inhibit PKC activity in CTRP3 treated RWPE-1 cells.	Staurosporine	17-30	proline rich transmembrane protein 2	Homo sapiens	52-55
26218761-11	2015	A PKC inhibitor, staurosporine, was used to inhibit PKC activity in CTRP3 treated RWPE-1 cells.	Staurosporine	17-30	C1q and TNF related 3	Homo sapiens	68-73
26218761-12	2015	Staurosporine completely abolished the CTRP3-induced increased phosphorylation of intracellular PKC substrates and CTRP3-stimulated effect by RWPE-1 cells.	Staurosporine	0-13	C1q and TNF related 3	Homo sapiens	39-44
26218761-12	2015	Staurosporine completely abolished the CTRP3-induced increased phosphorylation of intracellular PKC substrates and CTRP3-stimulated effect by RWPE-1 cells.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	96-99
26218761-12	2015	Staurosporine completely abolished the CTRP3-induced increased phosphorylation of intracellular PKC substrates and CTRP3-stimulated effect by RWPE-1 cells.	Staurosporine	0-13	C1q and TNF related 3	Homo sapiens	115-120
26361141-7	2015	Moreover, we found that protein kinase C (PKC) but not PKA phosphorylation influenced Claudin1 expression and cellular functions, as PKC inhibitor (Go 6983 and Staurosporine) or genetic silencing of PKC reduced Claudin1 expression and decreased the motility of KRIB and KHOS cells.	Staurosporine	160-173	claudin 1	Homo sapiens	211-219
26515010-7	2015	The assay functionality was demonstrated with a panel of EGFR inhibitors (AG-1478, compound 56, erlotinib, PD174265, and staurosporine).	Staurosporine	121-134	epidermal growth factor receptor	Homo sapiens	57-61
26356820-5	2015	Here we report that the PGAM5L, but not PGAM5S is a prerequisite for the activation of Bax and dephosphorylation of Drp1 in arenobufagin and staurosporine induced intrinsic apoptosis.	Staurosporine	141-154	collapsin response mediator protein 1	Homo sapiens	116-120
26356820-7	2015	The interaction between PGAM5L and Drp1 was observed in both arenobufagin and staurosporine treated HCT116 cells, but not in HCT116 Bax(-/-) cells.	Staurosporine	78-91	collapsin response mediator protein 1	Homo sapiens	35-39
26356820-8	2015	Bax transfection rescues the formation of the triplex in both arenobufagin and staurosporine stimulated HCT116 Bax(-/-) cells.	Staurosporine	79-92	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
26356820-8	2015	Bax transfection rescues the formation of the triplex in both arenobufagin and staurosporine stimulated HCT116 Bax(-/-) cells.	Staurosporine	79-92	BCL2 associated X, apoptosis regulator	Homo sapiens	111-114
26356820-10	2015	Bax-PGAM5L-Drp1 complex is detected in arenobufagin and staurosporine treated CRC cells in vitro and in arenobufagin and cisplatin treated tumor in vivo as well.	Staurosporine	56-69	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
26356820-10	2015	Bax-PGAM5L-Drp1 complex is detected in arenobufagin and staurosporine treated CRC cells in vitro and in arenobufagin and cisplatin treated tumor in vivo as well.	Staurosporine	56-69	collapsin response mediator protein 1	Homo sapiens	11-15
26304124-17	2015	Staurosporine, a broad-spectrum PKC inhibitor, inhibited both PA-mediated translocation of HuR and induction of HAMP expression.	Staurosporine	0-13	ELAV like RNA binding protein 1	Homo sapiens	91-94
26304124-17	2015	Staurosporine, a broad-spectrum PKC inhibitor, inhibited both PA-mediated translocation of HuR and induction of HAMP expression.	Staurosporine	0-13	hepcidin antimicrobial peptide	Homo sapiens	112-116
26190522-3	2015	Here, we show that exogenous IFNgamma has no deleterious impact on neuronal viability, and staurosporine-induced apoptosis in neurons is significantly blunted by the addition of IFNgamma, suggesting that IFNgamma confers a pro-survival signal in neurons.	Staurosporine	91-104	interferon gamma	Mus musculus	178-186
26190522-3	2015	Here, we show that exogenous IFNgamma has no deleterious impact on neuronal viability, and staurosporine-induced apoptosis in neurons is significantly blunted by the addition of IFNgamma, suggesting that IFNgamma confers a pro-survival signal in neurons.	Staurosporine	91-104	interferon gamma	Mus musculus	178-186
26366219-0	2015	Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44(+)/CD24(-)) in MCF-7 by Upregulating Mucin1 and EpCAM.	Staurosporine	0-13	CD44 molecule (Indian blood group)	Homo sapiens	69-73
26366219-0	2015	Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44(+)/CD24(-)) in MCF-7 by Upregulating Mucin1 and EpCAM.	Staurosporine	0-13	CD24 molecule	Homo sapiens	77-81
26366219-0	2015	Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44(+)/CD24(-)) in MCF-7 by Upregulating Mucin1 and EpCAM.	Staurosporine	0-13	mucin 1, cell surface associated	Homo sapiens	111-117
26366219-0	2015	Staurosporine Induced Apoptosis May Activate Cancer Stem-Like Cells (CD44(+)/CD24(-)) in MCF-7 by Upregulating Mucin1 and EpCAM.	Staurosporine	0-13	epithelial cell adhesion molecule	Homo sapiens	122-127
26366219-4	2015	Our results show that apart from an increase in the CD44(+)/CD24(-) population, proliferation and clone formation, but not migration, were enhanced after recovery from apoptosis induced by two pulses of staurosporine (STS).	Staurosporine	203-216	CD44 molecule (Indian blood group)	Homo sapiens	52-56
26366219-4	2015	Our results show that apart from an increase in the CD44(+)/CD24(-) population, proliferation and clone formation, but not migration, were enhanced after recovery from apoptosis induced by two pulses of staurosporine (STS).	Staurosporine	203-216	CD24 molecule	Homo sapiens	60-64
26032366-4	2015	Here, we demonstrated that histone H3 was cleaved by GzmA in vivo during staurosporine-induced cell death.	Staurosporine	73-86	granzyme A	Homo sapiens	53-57
26032366-6	2015	Taken together, we verified that histone H3 is a real substrate for GzmA in vivo in the Raji cells treated by staurosporin.	Staurosporine	110-122	granzyme A	Homo sapiens	68-72
25747661-9	2015	Moreover, PJ34 down-regulated the protein expression of IL-33 in activated hepatic stellate cells by cocktail of cytokines or staurosporine in vitro.	Staurosporine	126-139	interleukin 33	Mus musculus	56-61
25934031-7	2015	The PKC inhibitor, staurosporine (1 muM), in the patch pipette solution fully blocked the KA-induced potentiation of tonic inhibition, suggesting the involvement of an intracellular PKC pathway.	Staurosporine	19-32	latexin	Homo sapiens	36-39
26006035-5	2015	KEY FINDINGS: The cell adhesion assay showed that staurosporine induces adhesion of cervical cancer cells to the extracellular matrix (ECM) protein fibronectin.	Staurosporine	50-63	fibronectin 1	Homo sapiens	148-159
26006035-8	2015	Stroma cell induced transcription of matrix metalloprotease 1 (MMP1) and matrix metalloprotease 2 (MMP2) in cervical cancer cells was inhibited by staurosporine.	Staurosporine	147-160	matrix metallopeptidase 1	Homo sapiens	37-61
26006035-8	2015	Stroma cell induced transcription of matrix metalloprotease 1 (MMP1) and matrix metalloprotease 2 (MMP2) in cervical cancer cells was inhibited by staurosporine.	Staurosporine	147-160	matrix metallopeptidase 1	Homo sapiens	63-67
26006035-8	2015	Stroma cell induced transcription of matrix metalloprotease 1 (MMP1) and matrix metalloprotease 2 (MMP2) in cervical cancer cells was inhibited by staurosporine.	Staurosporine	147-160	matrix metallopeptidase 2	Homo sapiens	99-103
26047595-9	2015	Staurosporine, JNK inhibitor SP600125 and ERK inhibitor PD98059 significantly decreased DAX-1 expression in TNF-alpha-treated Leydig cells when compared to their respective controls.	Staurosporine	0-13	nuclear receptor subfamily 0, group B, member 1	Rattus norvegicus	88-93
26047595-9	2015	Staurosporine, JNK inhibitor SP600125 and ERK inhibitor PD98059 significantly decreased DAX-1 expression in TNF-alpha-treated Leydig cells when compared to their respective controls.	Staurosporine	0-13	tumor necrosis factor	Rattus norvegicus	108-117
26111701-12	2015	AngII mediated sensitization of capsaicin responses was not observed in the presence of MAP kinase inhibitor PD98059, and the kinase inhibitor staurosporine.	Staurosporine	143-156	angiotensinogen	Homo sapiens	0-5
25548949-3	2015	Specifically, we target glycosyltransferase, halogenase, and oxidoreductase genes from the phylogenetically related indolocarbazole rebeccamycin and staurosporine pathways.	Staurosporine	149-162	thioredoxin reductase 1	Homo sapiens	61-75
26015568-5	2015	Whereas Bok(-/-) mouse embryonic fibroblasts exposed to thapsigargin, A23187, brefeldin A, DTT, geldanamycin, or bortezomib manifested reduced activation of the mitochondrial apoptotic pathway, the death response to other stimuli such as etoposide, staurosporine, or UV remained fully intact.	Staurosporine	249-262	BCL2-related ovarian killer	Mus musculus	8-11
25937519-9	2015	Subsequently, the nucleic acid sequence of the viral P-protein was cloned and transfected into the macrophage cell line; the effect of this transfection on staurosporine-induced apoptosis was evaluated by assaying for cell viability and caspases-8 and -9 activity.	Staurosporine	156-169	OCA2 melanosomal transmembrane protein	Homo sapiens	53-62
25759387-7	2015	Staurosporine-induced nucleolar stress and apoptosis disrupt nucleolar PPAN localization and induce its accumulation in the cytoplasm.	Staurosporine	0-13	peter pan homolog	Homo sapiens	71-75
25348830-11	2015	The effect of juglone (10 muM) on annexin V binding was slightly but significantly blunted by removal of extracellular Ca(2+) and by addition of protein kinase C (PKC) inhibitor staurosporine (1 muM).	Staurosporine	178-191	latexin	Homo sapiens	26-29
25348830-11	2015	The effect of juglone (10 muM) on annexin V binding was slightly but significantly blunted by removal of extracellular Ca(2+) and by addition of protein kinase C (PKC) inhibitor staurosporine (1 muM).	Staurosporine	178-191	latexin	Homo sapiens	195-198
25308293-2	2015	In order to investigate the effect of chelerythrine and staurosporine on the activation of p53-dependent/-independent pathways of Dalton lymphoma (DL) cell death, cells were treated with chelerythrine and staurosporine for 1 h, 3 h and 6 h, respectively.	Staurosporine	56-69	transformation related protein 53, pseudogene	Mus musculus	91-94
25308293-3	2015	It was found that treatment with chelerythrine and staurosporine increased the expression of total-p53/phospho-53 (ser-15) significantly at protein and mRNA levels, which resulted in activation of the p53-dependent apoptotic pathway in DL cells.	Staurosporine	51-64	transformation related protein 53, pseudogene	Mus musculus	99-102
25308293-3	2015	It was found that treatment with chelerythrine and staurosporine increased the expression of total-p53/phospho-53 (ser-15) significantly at protein and mRNA levels, which resulted in activation of the p53-dependent apoptotic pathway in DL cells.	Staurosporine	51-64	transformation related protein 53, pseudogene	Mus musculus	201-204
25845498-6	2015	By using the Rho inhibitor CT04 (C3 transferase), the Rho-associated kinase (ROCK) inhibitors Y27632 and thiazovivin, the myosin light chain kinase (MLCK) inhibitor staurosporine or a G12/13 inhibitory construct, cell spreading was restored whereas the inhibition and activation of the Gq and Gs pathways had little or no effect.	Staurosporine	165-178	myosin light chain kinase	Homo sapiens	149-153
25680752-2	2015	In this study, we observed that STS treatment induced drastic morphologic changes, such as elongation of a very large number of nonbranched, actin-based long cell protrusions that reached up to 30 microm in an hour without caspase activation or PARP cleavage in fibroblasts and epithelial cells.	Staurosporine	32-35	poly(ADP-ribose) polymerase 1	Homo sapiens	245-249
25681439-5	2015	In intact cells, delivery of the BH4-Bcl-XL peptide via electroporation limits agonist-induced mitochondrial Ca(2+) uptake and protects against staurosporine-induced apoptosis, in line with the results obtained with VDAC1(-/-) cells.	Staurosporine	144-157	BCL2 like 1	Homo sapiens	37-43
25481756-4	2015	In this study, we demonstrated that CCHFV infection suppresses cleavage of poly(ADP-ribose) polymerase (PARP), triggered by staurosporine early post-infection.	Staurosporine	124-137	poly(ADP-ribose) polymerase 1	Homo sapiens	104-108
25670857-5	2015	We examined the role of tPA in macrophage survival, and found that tPA protected macrophages from both staurosporine and H2O2-induced apoptosis.	Staurosporine	103-116	plasminogen activator, tissue	Mus musculus	67-70
25627690-9	2015	Coupled with previous data, these results also indicate that PON2 uses its lactonase activity to prevent Bax- and Bak-dependent apoptosis in response to common proapoptotic drugs like doxorubicin and staurosporine, but activates Bax- and Bak-independent apoptosis in response to C12.	Staurosporine	200-213	paraoxonase 2	Homo sapiens	61-65
25627690-9	2015	Coupled with previous data, these results also indicate that PON2 uses its lactonase activity to prevent Bax- and Bak-dependent apoptosis in response to common proapoptotic drugs like doxorubicin and staurosporine, but activates Bax- and Bak-independent apoptosis in response to C12.	Staurosporine	200-213	BCL2 associated X, apoptosis regulator	Homo sapiens	105-108
25761242-3	2015	Upon application of staurosporine and to some extent after treatment with phorbol-12-myristate-13-acetate (PMA), a specific activator of protein kinase c, the caspase-3 sensitive peptide linker DEVD is cleaved.	Staurosporine	20-33	caspase 3	Homo sapiens	159-168
25078456-9	2015	Furthermore, AICR was inhibited by the protein kinase C inhibitor staurosporine, the nonspecific NADPH oxidase (NOX) inhibitors apocynin and diphenyleneiodonium, the NOX2-specific inhibitor gp91ds-tat, and the scavenger of reactive oxygen species (ROS) tempol.	Staurosporine	66-79	cytochrome b-245 beta chain	Rattus norvegicus	166-170
25487614-9	2015	For other staurosporine analogs, polyploidy was observed only in UCN-01-treated GLC-36 cells and in K252a-treated H1184 and GLC-36 cells.	Staurosporine	10-23	urocortin	Homo sapiens	65-68
25586139-5	2015	Here, we report that RBM5 knockdown in human neuronal cells decreases caspase activation by staurosporine.	Staurosporine	92-105	RNA binding motif protein 5	Homo sapiens	21-25
25601714-8	2015	Upregulation of Hsf4b can significantly inhibit cisplatin and staurosporine induced lens epithelial cell apoptosis through direct upregulation of Hsp25 and alphaB-crystallin expression.	Staurosporine	62-75	heat shock protein family B (small) member 1	Homo sapiens	146-151
25387797-7	2015	An antibody to Hsp70 delivered to SK-N-SH cells with high expression level of Hsp70 reduced the protective power of the chaperone and sensitized the cells to the pro-apoptotic effect of staurosporine.	Staurosporine	186-199	heat shock protein family A (Hsp70) member 4	Homo sapiens	15-20
25387797-7	2015	An antibody to Hsp70 delivered to SK-N-SH cells with high expression level of Hsp70 reduced the protective power of the chaperone and sensitized the cells to the pro-apoptotic effect of staurosporine.	Staurosporine	186-199	heat shock protein family A (Hsp70) member 4	Homo sapiens	78-83
26299070-0	2015	Staurosporine Induces Platelet Apoptosis Through p38 Mitogen-Activated Protein Kinase Signaling Pathway.	Staurosporine	0-13	mitogen-activated protein kinase 14	Homo sapiens	49-85
25462348-4	2015	Here we demonstrate that expression of functional EVM025 is crucial to prevent apoptosis triggered by virus infection and staurosporine.	Staurosporine	122-135	Hypothetical protein	Ectromelia virus	50-56
25524600-3	2015	We found that exogenous ERbeta was mainly expressed in mitochondrial but not in nuclear after ERbeta overexpression and protected cells from apoptosis induced by hydrogen peroxide (H2O2), ultraviolet (UV), and staurosporine (STS).	Staurosporine	210-223	estrogen receptor 2	Homo sapiens	24-30
25306914-6	2015	Hyperphosphorylation was abrogated in the presence of protein kinase A and protein kinase C inhibitors H89 (20 muM) and staurosporine (10 nM), respectively, as well as by specific antagonists to N-methyl-D-aspartate (50 microM DL-AP5) and metabotropic glutamate receptor 1 (100 microM MPEP).	Staurosporine	120-133	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	54-70
25306914-6	2015	Hyperphosphorylation was abrogated in the presence of protein kinase A and protein kinase C inhibitors H89 (20 muM) and staurosporine (10 nM), respectively, as well as by specific antagonists to N-methyl-D-aspartate (50 microM DL-AP5) and metabotropic glutamate receptor 1 (100 microM MPEP).	Staurosporine	120-133	glutamate metabotropic receptor 1	Rattus norvegicus	239-272
26299070-5	2015	Furthermore, STS stimulation induced phosphorylation of p38 mitogen-activated protein kinase (MAPK).	Staurosporine	13-16	mitogen-activated protein kinase 14	Homo sapiens	56-92
25039894-8	2014	Similar to in vivo findings, where GSH therapy in normoglycaemic mice suppressed endogenous antioxidants and augmented caspase-3 activity, GCLc overexpression during staurosporine-induced death, which was not characterized by ROS, increased GSH efflux and aggravated death in fibroblasts and cardiomyocytes, confirming that oxidative stress is required for GSH-mediated cytoprotection.	Staurosporine	166-179	glutamate-cysteine ligase, catalytic subunit	Mus musculus	139-143
26349604-2	2015	Ectopic expression of GLI1 in PW cells induced anchorage-independent growth and increased resistance to staurosporine-induced apoptosis, and overexpression of GLI1 in H441 cells caused resistance to apoptosis induced by staurosporine and etoposide.	Staurosporine	104-117	GLI family zinc finger 1	Homo sapiens	22-26
26349604-2	2015	Ectopic expression of GLI1 in PW cells induced anchorage-independent growth and increased resistance to staurosporine-induced apoptosis, and overexpression of GLI1 in H441 cells caused resistance to apoptosis induced by staurosporine and etoposide.	Staurosporine	220-233	GLI family zinc finger 1	Homo sapiens	22-26
26349604-2	2015	Ectopic expression of GLI1 in PW cells induced anchorage-independent growth and increased resistance to staurosporine-induced apoptosis, and overexpression of GLI1 in H441 cells caused resistance to apoptosis induced by staurosporine and etoposide.	Staurosporine	220-233	GLI family zinc finger 1	Homo sapiens	159-163
25464147-5	2015	After predetermining the gamma(458) of Venus to ECFP, we used sp-ECR method to monitor the staurosporine (STS)-induced dynamical caspase-3 activation in single live A549 cells expressing SCAT3 by spectrally resolving the absolute FRET efficiency of SCAT3, and found that STS-induced caspase-3 activation in single cells is a very rapid process within 20 min.	Staurosporine	91-104	caspase 3	Homo sapiens	129-138
25464147-5	2015	After predetermining the gamma(458) of Venus to ECFP, we used sp-ECR method to monitor the staurosporine (STS)-induced dynamical caspase-3 activation in single live A549 cells expressing SCAT3 by spectrally resolving the absolute FRET efficiency of SCAT3, and found that STS-induced caspase-3 activation in single cells is a very rapid process within 20 min.	Staurosporine	91-104	caspase 3	Homo sapiens	283-292
25464147-5	2015	After predetermining the gamma(458) of Venus to ECFP, we used sp-ECR method to monitor the staurosporine (STS)-induced dynamical caspase-3 activation in single live A549 cells expressing SCAT3 by spectrally resolving the absolute FRET efficiency of SCAT3, and found that STS-induced caspase-3 activation in single cells is a very rapid process within 20 min.	Staurosporine	106-109	caspase 3	Homo sapiens	129-138
25840418-2	2015	Staurosporine derivatives such as K252a and lestaurtinib have been developed to block TrkA kinase signaling, but no clinical trial has fully demonstrated their therapeutic efficacy.	Staurosporine	0-13	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	86-90
25531068-3	2014	We report a novel chemical strategy for selective FLT3 inhibition while avoiding KIT inhibition with the staurosporine analog, Star 27.	Staurosporine	105-118	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	81-84
25538629-12	2014	The PKC inhibitor staurosporine (0.2-2 x 10(-6) M) antagonized the proliferative actions of IbTX and TEA.	Staurosporine	18-31	proline rich transmembrane protein 2	Homo sapiens	4-7
25388371-6	2014	Mitochondrial membrane potential analysis revealed that NT2 and hNP1 cells, but not SH-SY5Y cells, undergo mitochondrial hyperpolarization in response to short-term exposure to STS prior to undergoing subsequent depolarization.	Staurosporine	177-180	neuronal pentraxin 1	Homo sapiens	64-68
25134723-9	2014	Finally, overexpression of CerK protected, whereas down-regulation of CerK with siRNA sensitized, cells for staurosporine-induced apoptosis.	Staurosporine	108-121	ceramide kinase	Homo sapiens	27-31
25134723-9	2014	Finally, overexpression of CerK protected, whereas down-regulation of CerK with siRNA sensitized, cells for staurosporine-induced apoptosis.	Staurosporine	108-121	ceramide kinase	Homo sapiens	70-74
25310532-7	2014	The anti-apoptotic effect was confirmed in vitro by a dose-dependent inhibition of both receptor-dependent (using tumor necrosis factor and Fas ligand) and receptor-independent (staurosporine) caspase-3 induction in HT29 colonic epithelial cells.	Staurosporine	178-191	caspase 3	Mus musculus	193-202
25419706-3	2014	Furthermore, neurons expressing T835M UNC5C are more susceptible to cell death from multiple neurotoxic stimuli, including beta-amyloid (Abeta), glutamate and staurosporine.	Staurosporine	159-172	unc-5 netrin receptor C	Homo sapiens	38-43
25117440-7	2014	When Ambra1 expression was reduced by siRNA, the cardiomyocytes were more sensitive to staurosporine-induced apoptosis.	Staurosporine	87-100	autophagy and beclin 1 regulator 1	Homo sapiens	5-11
25179574-8	2014	In contrast, Jak inhibitor 1 (pyridone 6) and staurosporine, both of which inhibit Jak2, had no effect on H2O2-induced increase in intracellular Ca(2+).	Staurosporine	46-59	Janus kinase 2	Homo sapiens	83-87
25016091-9	2014	Our results indicate that a series of protein kinase inhibitors, namely UCN-01 and OSU-03012 and to a lesser extent GSK2334470 and staurosporine induce PDK1 fragmentation and suggest that metalloproteinases could participate in this effect.	Staurosporine	131-144	pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial	Mesocricetus auratus	152-156
25055739-8	2014	Moreover, 2,4-dinitrophenol inhibits staurosporine-induced nuclear translocation of AIF and increases cisplatin resistance.	Staurosporine	37-50	apoptosis inducing factor mitochondria associated 1	Homo sapiens	84-87
24992930-6	2014	Importantly, a Par-4 mutant that is unable to bind Fbxo45 is stabilized and further enhances staurosporine-induced apoptosis.	Staurosporine	93-106	pro-apoptotic WT1 regulator	Homo sapiens	15-20
24700109-2	2014	At low concentrations (1-10 nM), staurosporine causes the collapse and loss of hair bundles without provoking hair-cell death, as judged by lack of terminal transferase dUTP nick end labeling (TUNEL) labeling or reactivity to anti-activated caspase-3.	Staurosporine	33-46	caspase 3	Mus musculus	241-250
24700109-5	2014	Staurosporine treatment causes a reduction in levels of the phosphorylated forms of ezrin, radixin, and moesin in cochlear cultures during the period of hair-bundle loss, indicating the integrity of the hair bundle may be actively maintained by the phosphorylation status of these proteins.	Staurosporine	0-13	moesin	Mus musculus	104-110
24998494-0	2014	Dual response of the KATP channels to staurosporine: a novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes.	Staurosporine	38-51	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	76-80
24998494-0	2014	Dual response of the KATP channels to staurosporine: a novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes.	Staurosporine	38-51	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	85-91
24998494-1	2014	We investigated on the role of the genes encoding for the ATP-sensitive K(+)-channel (KATP) subunits (SUR1-2A/B, Kir6.2) in the atrophy induced "in vitro" by staurosporine (STS) in different skeletal muscle phenotypes of mouse.	Staurosporine	158-171	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	102-106
24998494-1	2014	We investigated on the role of the genes encoding for the ATP-sensitive K(+)-channel (KATP) subunits (SUR1-2A/B, Kir6.2) in the atrophy induced "in vitro" by staurosporine (STS) in different skeletal muscle phenotypes of mouse.	Staurosporine	158-171	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	113-119
25111382-2	2014	Herein we describe the crystal structure of PRK1 in apo form, and also in complex with a panel of literature inhibitors including the clinical candidates lestaurtinib and tofacitinib, as well as the staurosporine analog Ro-31-8220.	Staurosporine	199-212	protein kinase N1	Homo sapiens	44-48
25004807-8	2014	Staurosporine-treated H295R cells showed an increase of PARP cleavage and of annexin-V expression, when adherent to type V collagen.	Staurosporine	0-13	collagen type XI alpha 2 chain	Homo sapiens	56-60
25004807-8	2014	Staurosporine-treated H295R cells showed an increase of PARP cleavage and of annexin-V expression, when adherent to type V collagen.	Staurosporine	0-13	annexin A5	Homo sapiens	77-86
25004807-9	2014	Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V collagen didn"t modify Akt activation, while determined a dramatic inhibition of Erk activation.	Staurosporine	5-18	AKT serine/threonine kinase 1	Homo sapiens	27-30
25004807-9	2014	Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V collagen didn"t modify Akt activation, while determined a dramatic inhibition of Erk activation.	Staurosporine	5-18	mitogen-activated protein kinase 1	Homo sapiens	35-38
25004807-9	2014	Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V collagen didn"t modify Akt activation, while determined a dramatic inhibition of Erk activation.	Staurosporine	5-18	mitogen-activated protein kinase 1	Homo sapiens	170-173
25004807-10	2014	The described data demonstrate that the adhesion to type V collagen specifically increases the responsiveness of ACC cells to staurosporine-induced apoptosis and that this is probably obtained through the inhibition of Erk activation.	Staurosporine	126-139	mitogen-activated protein kinase 1	Homo sapiens	219-222
25078151-2	2014	The crystal structures of the S6K1 kinase domain in complexes with staurosporine and the S6K1-specific inhibitor PF-4708671 have been reported.	Staurosporine	67-80	ribosomal protein S6 kinase B1	Homo sapiens	30-34
25168879-0	2014	Staurosporine synergistically potentiates the deoxycholate-mediated induction of COX-2 expression.	Staurosporine	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86
25168879-6	2014	We found that staurosporine (sts), a potent protein kinase C (PKC) inhibitor, synergistically potentiated the deoxycholate-mediated induction of COX-2 expression.	Staurosporine	14-27	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
25168879-6	2014	We found that staurosporine (sts), a potent protein kinase C (PKC) inhibitor, synergistically potentiated the deoxycholate-mediated induction of COX-2 expression.	Staurosporine	29-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150
25168879-12	2014	We conclude that staurosporine synergistically enhances deoxycholate-induced COX-2 expression in RCM-1 colon cancer cells.	Staurosporine	17-30	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	77-82
25202074-5	2014	RESULTS: Adjuvant HSP27 knockdown with 17-AAG or staurosporine produced marked and synergistic decrease in GBM cell viability and proliferation, with robust elevation of apoptotic fractions and caspase-3 activation.	Staurosporine	49-62	heat shock protein family B (small) member 1	Homo sapiens	18-23
24794067-5	2014	RESULTS AND CONCLUSIONS: We demonstrated that overexpression of CA8 in neuronal cells significantly decreased cell death under staurosporine treatment.	Staurosporine	127-140	carbonic anhydrase VIII	Danio rerio	64-67
25061096-13	2014	Consistent with these findings, small interference RNA silencing of THBS1 in luteal cells reduced the levels of active caspase-3 and improved the survival of cells when challenged with staurosporine.	Staurosporine	185-198	thrombospondin 1	Bos taurus	68-73
25168906-10	2014	While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation.	Staurosporine	154-167	granzyme B	Homo sapiens	104-107
25036040-11	2014	Staurosporine blocked the cell cycle via p53 and p21, but also promoted cell growth via activated HDAC1 and its downstream pathway.	Staurosporine	0-13	tumor protein p53	Homo sapiens	41-44
24973211-6	2014	Thus, in apoptosis of neuronal and non-neuronal cells induced by various stimuli including staurosporine, etoposide, or 6-hydroxydopamine, the cleavage of anamorsin was found to be blocked in the presence of caspase inhibitor.	Staurosporine	91-104	cytokine induced apoptosis inhibitor 1	Mus musculus	155-164
24953606-8	2014	Staurosporine, the c-Jun N-terminal kinase (JNK) inhibitor SP600125 and the p38 mitogen-activated protein kinase (p38 MAPK) inhibitor SB203580 significantly increased Pax6 levels in high glucose-treated INS-1E cells compared to their respective controls.	Staurosporine	0-13	paired box 6	Rattus norvegicus	167-171
25042549-9	2014	Short-term treatment with MG132 (0.3 mumol/L, up to 8 h) significantly increased both LDLR mRNA and protein levels in HepG2 cells, which was blocked by the specific PKC inhibitors GF 109203X, Go 6983 or staurosporine.	Staurosporine	203-216	low density lipoprotein receptor	Homo sapiens	86-90
24703106-0	2014	Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.	Staurosporine	90-103	RB binding protein 6, ubiquitin ligase	Homo sapiens	10-15
24703106-0	2014	Silencing RBBP6 (Retinoblastoma Binding Protein 6) sensitises breast cancer cells MCF7 to staurosporine and camptothecin-induced cell death.	Staurosporine	90-103	RB binding protein 6, ubiquitin ligase	Homo sapiens	17-49
24703106-8	2014	About 20.7% increase in apoptosis was observed in cells co-treated with RBBP6 siRNA and camptothecin when compared to camptothecin-only whereas in siRBBP6 and staurosporine treated cells there was only an 8.8% increase in apoptosis.	Staurosporine	159-172	RB binding protein 6, ubiquitin ligase	Homo sapiens	72-77
25036040-11	2014	Staurosporine blocked the cell cycle via p53 and p21, but also promoted cell growth via activated HDAC1 and its downstream pathway.	Staurosporine	0-13	H3 histone pseudogene 16	Homo sapiens	49-52
25036040-11	2014	Staurosporine blocked the cell cycle via p53 and p21, but also promoted cell growth via activated HDAC1 and its downstream pathway.	Staurosporine	0-13	histone deacetylase 1	Homo sapiens	98-103
25010987-7	2014	Functionally, an elevation in caspase-2 level by HuR knockdown correlated with an increased sensitivity of cells to apoptosis induced by staurosporine- and pore-forming toxins as implicated by their significant accumulation in the sub G1 phase and an increase in caspase-2, -3 and poly ADP-ribose polymerase cleavage, respectively.	Staurosporine	137-150	caspase 2	Homo sapiens	30-39
25010987-7	2014	Functionally, an elevation in caspase-2 level by HuR knockdown correlated with an increased sensitivity of cells to apoptosis induced by staurosporine- and pore-forming toxins as implicated by their significant accumulation in the sub G1 phase and an increase in caspase-2, -3 and poly ADP-ribose polymerase cleavage, respectively.	Staurosporine	137-150	ELAV like RNA binding protein 1	Homo sapiens	49-52
25010987-7	2014	Functionally, an elevation in caspase-2 level by HuR knockdown correlated with an increased sensitivity of cells to apoptosis induced by staurosporine- and pore-forming toxins as implicated by their significant accumulation in the sub G1 phase and an increase in caspase-2, -3 and poly ADP-ribose polymerase cleavage, respectively.	Staurosporine	137-150	poly(ADP-ribose) polymerase 1	Homo sapiens	263-307
24849604-10	2014	Both KCC2(T934D) and KCC2(S937D) mutants were inhibited by the kinase inhibitor staurosporine and by N-ethylmaleimide, whereas KCC2(WT), KCC2(T934A), and KCC2(S937A) were activated.	Staurosporine	80-93	solute carrier family 12 member 5	Homo sapiens	5-9
24849604-10	2014	Both KCC2(T934D) and KCC2(S937D) mutants were inhibited by the kinase inhibitor staurosporine and by N-ethylmaleimide, whereas KCC2(WT), KCC2(T934A), and KCC2(S937A) were activated.	Staurosporine	80-93	solute carrier family 12 member 5	Homo sapiens	21-25
24849604-10	2014	Both KCC2(T934D) and KCC2(S937D) mutants were inhibited by the kinase inhibitor staurosporine and by N-ethylmaleimide, whereas KCC2(WT), KCC2(T934A), and KCC2(S937A) were activated.	Staurosporine	80-93	solute carrier family 12 member 5	Homo sapiens	127-135
24849604-10	2014	Both KCC2(T934D) and KCC2(S937D) mutants were inhibited by the kinase inhibitor staurosporine and by N-ethylmaleimide, whereas KCC2(WT), KCC2(T934A), and KCC2(S937A) were activated.	Staurosporine	80-93	solute carrier family 12 member 5	Homo sapiens	21-25
24849604-10	2014	Both KCC2(T934D) and KCC2(S937D) mutants were inhibited by the kinase inhibitor staurosporine and by N-ethylmaleimide, whereas KCC2(WT), KCC2(T934A), and KCC2(S937A) were activated.	Staurosporine	80-93	solute carrier family 12 member 5	Homo sapiens	21-25
24849604-11	2014	The inverse staurosporine effect on aspartate versus alanine substitutions reveals a cross-talk between different phosphorylation sites of KCC2.	Staurosporine	12-25	solute carrier family 12 member 5	Homo sapiens	139-143
24438098-6	2014	A DKO MEF line that was relatively unaffected by the Bak/Bax-dependent proapoptotic stimulants staurosporine and etoposide responded to C12 similarly to WT MEF: activation of caspase 3/7, depolarization of Deltapsimito and release of cytochrome C and cell death.	Staurosporine	95-108	BCL2-associated X protein	Mus musculus	57-60
24849604-0	2014	A novel regulatory locus of phosphorylation in the C terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine-mediated activation.	Staurosporine	148-161	solute carrier family 12 member 5	Homo sapiens	102-106
24658966-7	2014	This finding was subsequently solidified by in vitro kinase assay experiment; the inhibitory IC50 values of Staurosporine against wild-type, T790M and T790M/L858R mutant EGFR were measured to be 937, 12 and 3 nM, respectively.	Staurosporine	108-121	epidermal growth factor receptor	Homo sapiens	170-174
24703880-8	2014	Inhibition of apoptosis or staurosporine-induced apoptosis by halofuginone in mdx primary myoblasts and C2 myogenic cell line, respectively, was reflected by less pyknotic/apoptotic cells and reduced Bax expression.	Staurosporine	27-40	BCL2-associated X protein	Mus musculus	200-203
24761782-0	2014	N-carbamidoyl-4-((3-ethyl-2,4,4-trimethylcyclohexyl)methyl)benzamide enhances staurosporine cytotoxic effects likely inhibiting the protective action of Magmas toward cell apoptosis.	Staurosporine	78-91	presequence translocase associated motor 16	Homo sapiens	153-159
24746749-5	2014	Furthermore, molecular modeling studies indicate that both AOPHA-Me and PBA dock at the ATP binding site of apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPKs upstream of both JNK and p38 MAPK, with predicted interaction energies of -7.0 kcal/mol and -5.9 kcal/mol, respectively; this binding overlaps with that of staurosporine, a known inhibitor of ASK1.	Staurosporine	331-344	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	108-144
24746749-5	2014	Furthermore, molecular modeling studies indicate that both AOPHA-Me and PBA dock at the ATP binding site of apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPKs upstream of both JNK and p38 MAPK, with predicted interaction energies of -7.0 kcal/mol and -5.9 kcal/mol, respectively; this binding overlaps with that of staurosporine, a known inhibitor of ASK1.	Staurosporine	331-344	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	146-150
24746749-5	2014	Furthermore, molecular modeling studies indicate that both AOPHA-Me and PBA dock at the ATP binding site of apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPKs upstream of both JNK and p38 MAPK, with predicted interaction energies of -7.0 kcal/mol and -5.9 kcal/mol, respectively; this binding overlaps with that of staurosporine, a known inhibitor of ASK1.	Staurosporine	331-344	mitogen-activated protein kinase 8	Homo sapiens	192-195
24746749-5	2014	Furthermore, molecular modeling studies indicate that both AOPHA-Me and PBA dock at the ATP binding site of apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPKs upstream of both JNK and p38 MAPK, with predicted interaction energies of -7.0 kcal/mol and -5.9 kcal/mol, respectively; this binding overlaps with that of staurosporine, a known inhibitor of ASK1.	Staurosporine	331-344	mitogen-activated protein kinase 14	Homo sapiens	200-203
24967918-8	2014	GPAT2 knockdown diminished cell proliferation, anchorage independent growth, migration and tumorigenicity, and increased staurosporine-induced apoptosis.	Staurosporine	121-134	glycerol-3-phosphate acyltransferase 2, mitochondrial	Homo sapiens	0-5
24967918-9	2014	In contrast, GPAT2 over-expression increased cell proliferation rate and resistance to staurosporine-induced apoptosis.	Staurosporine	87-100	glycerol-3-phosphate acyltransferase 2, mitochondrial	Homo sapiens	13-18
24761782-1	2014	We recently demonstrated that Magmas overexpression protects GH-secreting rat pitutitary adenoma cell lines from apoptosis by inhibiting cytochrome c release from mitochondria after treatment with staurosporine, strongly suggesting a role of Magmas in preventing apoptosis.	Staurosporine	197-210	mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, pseudogene 1	Rattus norvegicus	30-36
24828410-8	2014	OA blocks neurite retraction induced by propofol, and this inhibitory effect could be prevented by FIPI, staurosporine and PKCepsilon translocation inhibitor peptide.	Staurosporine	105-118	hypocretin neuropeptide precursor	Rattus norvegicus	0-2
24927102-9	2014	In conclusion, we demonstrated that TCDD promoted NNK-induced lung tumorigenesis and revealed that TCDD inhibits staurosporine-induced apoptosis, at least in part, through the Akt and ERK1/2 signaling pathways.	Staurosporine	113-126	AKT serine/threonine kinase 1	Homo sapiens	176-179
24927102-9	2014	In conclusion, we demonstrated that TCDD promoted NNK-induced lung tumorigenesis and revealed that TCDD inhibits staurosporine-induced apoptosis, at least in part, through the Akt and ERK1/2 signaling pathways.	Staurosporine	113-126	mitogen-activated protein kinase 3	Homo sapiens	184-190
24446161-5	2014	Pretreatments with LY294002, wortmannin, and staurosporine completely blocked the induction effect, suggesting the involvement of both phosphoinositide 3-kinase (PI 3-K) and protein kinase C (PKC) pathways.	Staurosporine	45-58	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	135-160
24920883-7	2014	One of the compounds, RBC1023, was demonstrated to protect NIH3T3 cells from staurosporine-induced caspase-3 cleavage and activation.	Staurosporine	77-90	caspase 3	Mus musculus	99-108
24920883-9	2014	DNA microarray analysis demonstrated that staurosporine treatment induced broad global gene expression alterations, and RBC1023 co-treatment significantly restored these changes, especially of the genes that are related to cell growth and survival signaling such as Egr1, Cdc25c, cdkn3, Rhob, Nek2, and Taok1.	Staurosporine	42-55	early growth response 1	Mus musculus	266-270
24920883-9	2014	DNA microarray analysis demonstrated that staurosporine treatment induced broad global gene expression alterations, and RBC1023 co-treatment significantly restored these changes, especially of the genes that are related to cell growth and survival signaling such as Egr1, Cdc25c, cdkn3, Rhob, Nek2, and Taok1.	Staurosporine	42-55	cell division cycle 25C	Mus musculus	272-278
24920883-9	2014	DNA microarray analysis demonstrated that staurosporine treatment induced broad global gene expression alterations, and RBC1023 co-treatment significantly restored these changes, especially of the genes that are related to cell growth and survival signaling such as Egr1, Cdc25c, cdkn3, Rhob, Nek2, and Taok1.	Staurosporine	42-55	cyclin-dependent kinase inhibitor 3	Mus musculus	280-285
24920883-9	2014	DNA microarray analysis demonstrated that staurosporine treatment induced broad global gene expression alterations, and RBC1023 co-treatment significantly restored these changes, especially of the genes that are related to cell growth and survival signaling such as Egr1, Cdc25c, cdkn3, Rhob, Nek2, and Taok1.	Staurosporine	42-55	ras homolog family member B	Mus musculus	287-291
24920883-9	2014	DNA microarray analysis demonstrated that staurosporine treatment induced broad global gene expression alterations, and RBC1023 co-treatment significantly restored these changes, especially of the genes that are related to cell growth and survival signaling such as Egr1, Cdc25c, cdkn3, Rhob, Nek2, and Taok1.	Staurosporine	42-55	NIMA (never in mitosis gene a)-related expressed kinase 2	Mus musculus	293-297
24920883-9	2014	DNA microarray analysis demonstrated that staurosporine treatment induced broad global gene expression alterations, and RBC1023 co-treatment significantly restored these changes, especially of the genes that are related to cell growth and survival signaling such as Egr1, Cdc25c, cdkn3, Rhob, Nek2, and Taok1.	Staurosporine	42-55	TAO kinase 1	Mus musculus	303-308
24838313-8	2014	However, staurosporine-pretreated LN-18 cytoplasms do not induce DNA laddering in isolated nuclei from either LN-18 or SH-SY5Y cells because LN-18 cells express lower amounts of DFF40/CAD.	Staurosporine	9-22	DNA fragmentation factor subunit beta	Homo sapiens	178-183
24838313-8	2014	However, staurosporine-pretreated LN-18 cytoplasms do not induce DNA laddering in isolated nuclei from either LN-18 or SH-SY5Y cells because LN-18 cells express lower amounts of DFF40/CAD.	Staurosporine	9-22	aconitate decarboxylase 1	Homo sapiens	184-187
24963283-0	2014	Calbindin-D28K Prevents Staurosporin-induced Bax Cleavage and Membrane Permeabilization.	Staurosporine	24-36	BCL2 associated X, apoptosis regulator	Homo sapiens	45-48
24422709-6	2014	Staurosporine-stimulated activation of caspase-3 was also similar between the low (2.3 +- 0.2 ng/mL), moderate (2.1 +- 0.3 ng/mL), and high (2.2 +- 0.2 ng/mL) CRP groups.	Staurosporine	0-13	caspase 3	Homo sapiens	39-48
24885713-9	2014	RESULTS: Caspase-3 expression in staurosporine-incubated cells increased by 471% +- 182% compared to control (P=0.014).	Staurosporine	33-46	caspase 3	Homo sapiens	9-18
25898737-4	2014	At the same cell death level, activity of caspase-3 and caspase-9 in the cells incubated with 14G2a was about 7.5- and 3-fold lower than in cells after incubation with staurosporine.	Staurosporine	168-181	caspase 3	Mus musculus	42-51
25898737-4	2014	At the same cell death level, activity of caspase-3 and caspase-9 in the cells incubated with 14G2a was about 7.5- and 3-fold lower than in cells after incubation with staurosporine.	Staurosporine	168-181	caspase 9	Mus musculus	56-65
25898737-6	2014	At the same conditions, pan caspase inhibitor decreased staurosporine-induced apoptosis at 55-65%.	Staurosporine	56-69	caspase 9	Mus musculus	28-35
24682423-6	2014	This effect could be prevented using the PKC inhibitor staurosporine.	Staurosporine	55-68	protein kinase C alpha	Homo sapiens	41-44
24769642-2	2014	In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced protein level of CCAAT/enhancer binding protein epsilon (C/EBPepsilon) and C/EBPbeta as well as the phosphorylation of mitogen-activated protein (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	71-84	CCAAT enhancer binding protein epsilon	Homo sapiens	227-239
24769642-2	2014	In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced protein level of CCAAT/enhancer binding protein epsilon (C/EBPepsilon) and C/EBPbeta as well as the phosphorylation of mitogen-activated protein (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	71-84	CCAAT enhancer binding protein beta	Homo sapiens	245-254
24769642-2	2014	In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced protein level of CCAAT/enhancer binding protein epsilon (C/EBPepsilon) and C/EBPbeta as well as the phosphorylation of mitogen-activated protein (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	71-84	mitogen-activated protein kinase kinase 7	Homo sapiens	316-319
24769642-2	2014	In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced protein level of CCAAT/enhancer binding protein epsilon (C/EBPepsilon) and C/EBPbeta as well as the phosphorylation of mitogen-activated protein (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	71-84	mitogen-activated protein kinase 1	Homo sapiens	325-362
24769642-2	2014	In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced protein level of CCAAT/enhancer binding protein epsilon (C/EBPepsilon) and C/EBPbeta as well as the phosphorylation of mitogen-activated protein (MEK) and extracellular signal-regulated kinase (ERK).	Staurosporine	71-84	mitogen-activated protein kinase 1	Homo sapiens	364-367
24769642-4	2014	Taken together, we concluded that the combination of ATRA and staurosporine could overcome differentiation block via MEK/ERK signaling pathway in ATRA-resistant APL cell lines.	Staurosporine	62-75	mitogen-activated protein kinase kinase 7	Homo sapiens	117-120
24769642-4	2014	Taken together, we concluded that the combination of ATRA and staurosporine could overcome differentiation block via MEK/ERK signaling pathway in ATRA-resistant APL cell lines.	Staurosporine	62-75	mitogen-activated protein kinase 1	Homo sapiens	121-124
24506253-4	2014	Novel small-molecule inhibitors of PKCdelta were designed as chimeric hybrids of two naturally occurring PKCdelta inhibitors, staurosporine and rottlerin.	Staurosporine	126-139	protein kinase C delta	Homo sapiens	35-43
24819773-8	2014	The action of the G protein coupled receptor phospholipase C pathway appears to be essential for the induction of NETs by IL-8, as NETosis was diminished by treatment with either pertussis toxin, a G-protein inhibitor, the phospholipase C inhibitor, U73122, or staurosporine, an inhibitor of protein kinase C. The data regarding the calcineurin antagonists, ascomycin and cyclosporine A, open the possibility to therapeutically suppress or modulate NETosis.	Staurosporine	261-274	C-X-C motif chemokine ligand 8	Homo sapiens	122-126
24699552-7	2014	Overexpression of the different variants of Spink2 in D407 tissue culture cells also increases their susceptibility to the apoptosis-inducing agent staurosporine in a manner consistent with the differential susceptibility between the DBA/2J and BALB/cByJ strains.	Staurosporine	148-161	serine peptidase inhibitor Kazal type 2	Homo sapiens	44-50
24476000-5	2014	The results of the present study showed that overexpression of CA8 in MERRF cybrids significantly decreased cell death induced by STS (staurosporine) treatment, suggesting a protective function of CA8 in cells harbouring the A8344G mutation of mtDNA.	Staurosporine	135-148	carbonic anhydrase 8	Homo sapiens	63-66
24022164-5	2014	In terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, the anti-apoptotic effect of GM-CSF (apoptotic population of approximately 8.17 %) on staurosporine-induced apoptosis of NPCs (31.09 %) was significantly blocked by LY294002, an inhibitor of PI3K signal (24.04 %).	Staurosporine	165-178	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	108-114
24343863-10	2014	Based on this finding, we performed a flow cytometry-based functional analysis of STAT1 GOF alleles using IFN-gamma stimulation and the tyrosine kinase inhibitor, staurosporine.	Staurosporine	163-176	signal transducer and activator of transcription 1	Homo sapiens	82-87
24343863-11	2014	The higher levels of pSTAT1 observed in primary CD14(+) cells from patients compared with control cells persisted and were amplified by the presence of staurosporine.	Staurosporine	152-165	CD14 molecule	Homo sapiens	48-52
24022164-9	2014	Each of the specific siRNAs for NF-kappaB, HIF-1alpha, and survivin inhibited significantly the anti-apoptotic activity of GM-CSF on the staurosporine-induced apoptosis in NPCs in TUNEL assays.	Staurosporine	137-150	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	123-129
24022164-9	2014	Each of the specific siRNAs for NF-kappaB, HIF-1alpha, and survivin inhibited significantly the anti-apoptotic activity of GM-CSF on the staurosporine-induced apoptosis in NPCs in TUNEL assays.	Staurosporine	137-150	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	32-41
24022164-9	2014	Each of the specific siRNAs for NF-kappaB, HIF-1alpha, and survivin inhibited significantly the anti-apoptotic activity of GM-CSF on the staurosporine-induced apoptosis in NPCs in TUNEL assays.	Staurosporine	137-150	hypoxia inducible factor 1, alpha subunit	Mus musculus	43-53
24022164-9	2014	Each of the specific siRNAs for NF-kappaB, HIF-1alpha, and survivin inhibited significantly the anti-apoptotic activity of GM-CSF on the staurosporine-induced apoptosis in NPCs in TUNEL assays.	Staurosporine	137-150	baculoviral IAP repeat-containing 5	Mus musculus	59-67
24618884-7	2014	Evidence for the physical association of HMGB1 comes from Western blot analysis of microparticles derived from RAW 264.7 macrophage cells stimulated by lipopolysaccharide (LPS) or induced to undergo apoptosis by treatment with etoposide or staurosporine in vitro.	Staurosporine	240-253	high mobility group box 1	Mus musculus	41-46
23999908-7	2014	We illustrate the improved performance of our protocol through crossdocking of 31 ligands to cocomplexed proteins of the kinase 3-phosphoinositide dependent protein kinase-1 extracted from the crystal structures 1H1W (ATP bound), 1OKY (staurosporine bound) and 3QD0 (bound to a potent inhibitor).	Staurosporine	236-249	3-phosphoinositide dependent protein kinase 1	Homo sapiens	128-173
24508257-6	2014	The addition of staurosporine, which is known to pharmacologically activate caspase enzymes, increased processing of the human HDC protein.	Staurosporine	16-29	caspase 6	Rattus norvegicus	76-83
24508257-6	2014	The addition of staurosporine, which is known to pharmacologically activate caspase enzymes, increased processing of the human HDC protein.	Staurosporine	16-29	histidine decarboxylase	Homo sapiens	127-130
24398589-6	2014	Even with lethal stress such as staurosporine (STS), HuR in the cytoplasm was never downregulated, and caspase-3 activity was inhibited when cells expressed pp32r1.	Staurosporine	32-45	acidic nuclear phosphoprotein 32 family member C	Homo sapiens	157-163
24398589-6	2014	Even with lethal stress such as staurosporine (STS), HuR in the cytoplasm was never downregulated, and caspase-3 activity was inhibited when cells expressed pp32r1.	Staurosporine	47-50	acidic nuclear phosphoprotein 32 family member C	Homo sapiens	157-163
24582574-10	2014	Staurosporine induced mesendoderm in the absence of known inducers of formation, such as serum and BMP4.	Staurosporine	0-13	bone morphogenetic protein 4	Homo sapiens	99-103
24500985-8	2014	In addition, the expression of Smad3 and Smad7 was significantly reduced not only by staurosporine, an inhibitor of threonine/serine protein kinases as well as smad, but also by NS-398, an inhibitor of COX-2.	Staurosporine	85-98	SMAD family member 3	Rattus norvegicus	31-36
24500985-8	2014	In addition, the expression of Smad3 and Smad7 was significantly reduced not only by staurosporine, an inhibitor of threonine/serine protein kinases as well as smad, but also by NS-398, an inhibitor of COX-2.	Staurosporine	85-98	SMAD family member 7	Rattus norvegicus	41-46
24500985-8	2014	In addition, the expression of Smad3 and Smad7 was significantly reduced not only by staurosporine, an inhibitor of threonine/serine protein kinases as well as smad, but also by NS-398, an inhibitor of COX-2.	Staurosporine	85-98	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	202-207
24237253-5	2014	In contrast, CD61 (integrin beta3) and CD42b (GP1balpha) expression, markers of megakaryocytic differentiation, was increased by staurosporine, but did not change significantly by NH2Cl and U0126.	Staurosporine	129-142	integrin subunit beta 3	Homo sapiens	13-17
24237253-5	2014	In contrast, CD61 (integrin beta3) and CD42b (GP1balpha) expression, markers of megakaryocytic differentiation, was increased by staurosporine, but did not change significantly by NH2Cl and U0126.	Staurosporine	129-142	integrin subunit beta 3	Homo sapiens	19-33
24237253-5	2014	In contrast, CD61 (integrin beta3) and CD42b (GP1balpha) expression, markers of megakaryocytic differentiation, was increased by staurosporine, but did not change significantly by NH2Cl and U0126.	Staurosporine	129-142	glycoprotein Ib platelet subunit alpha	Homo sapiens	39-44
24237253-5	2014	In contrast, CD61 (integrin beta3) and CD42b (GP1balpha) expression, markers of megakaryocytic differentiation, was increased by staurosporine, but did not change significantly by NH2Cl and U0126.	Staurosporine	129-142	glycoprotein Ib platelet subunit alpha	Homo sapiens	46-55
24120758-4	2014	Here, we show that similar to bortezomib, the novel proteasome inhibitors carfilzomib and ixazomib, as well as staurosporine and adaphostin, induce the generation of Mcl-1(128-350) in MM cells.	Staurosporine	111-124	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	166-171
24587252-5	2014	Ambra1 expression was detected by Western blot in SW620 cells treated with staurosporine or etoposide.	Staurosporine	75-88	autophagy and beclin 1 regulator 1	Homo sapiens	0-6
24421315-7	2014	PDGF-C prevented staurosporine-induced macrophage apoptosis by inhibiting the activation of caspase-3, -7, -8, and -9 and cleavage of poly(ADP-ribose) polymerase.	Staurosporine	17-30	platelet derived growth factor C	Homo sapiens	0-6
24421315-7	2014	PDGF-C prevented staurosporine-induced macrophage apoptosis by inhibiting the activation of caspase-3, -7, -8, and -9 and cleavage of poly(ADP-ribose) polymerase.	Staurosporine	17-30	caspase 3	Homo sapiens	92-117
24421315-7	2014	PDGF-C prevented staurosporine-induced macrophage apoptosis by inhibiting the activation of caspase-3, -7, -8, and -9 and cleavage of poly(ADP-ribose) polymerase.	Staurosporine	17-30	poly(ADP-ribose) polymerase 1	Homo sapiens	134-161
24586258-2	2014	Here, we show that four out of five SCLC cell lines reversibly develop a neuron-like phenotype on extracellular matrix constituents such as fibronectin, laminin or thrombospondin upon staurosporine treatment in an RGD/integrin-mediated manner.	Staurosporine	184-197	fibronectin 1	Homo sapiens	140-151
24587252-10	2014	Ambra1 expression decreased during staurosporine- or etoposide-induced apoptosis.	Staurosporine	35-48	autophagy and beclin 1 regulator 1	Homo sapiens	0-6
24587252-12	2014	When Ambra1 expression was reduced by siRNA, SW620 cells were more sensitive to staurosporine- or etoposide-induced apoptosis.	Staurosporine	80-93	autophagy and beclin 1 regulator 1	Homo sapiens	5-11
24397909-7	2014	In addition, staurosporine treatment resulted in activation of the PINK1-Parkin mitophagy pathway, of which deficit underlies some familial cases of PD, in the dopaminergic neuronal cell line, SN4741.	Staurosporine	13-26	PTEN induced kinase 1	Homo sapiens	67-72
24397909-8	2014	The genetic blockade of this pathway by PINK1 null mutation also dramatically increased staurosporine-induced cell death.	Staurosporine	88-101	PTEN induced kinase 1	Homo sapiens	40-45
24219236-7	2014	In addition, both compounds were able to reduce caspase-3 activity induced by the apoptotic enhancer staurosporine, but undecylprodigiosin failed to inhibit FCCP effects and it did not act over the Nrf2 pathway as was the case for anhydroexfoliamycin.	Staurosporine	101-114	caspase 3	Homo sapiens	48-57
24363429-8	2014	In line with a broad role of caspase-3 in the execution of apoptosis, the processing of MyD88 was not restricted to Yersinia infection and to proapoptotic Toll-IL-1R domain-containing adapter inducing IFN-beta signaling, but was also triggered by staurosporine treatment.	Staurosporine	247-260	MYD88 innate immune signal transduction adaptor	Homo sapiens	88-93
24067927-0	2014	Staurosporine induces dopaminergic neurite outgrowth through AMP-activated protein kinase/mammalian target of rapamycin signaling pathway.	Staurosporine	0-13	mechanistic target of rapamycin kinase	Homo sapiens	90-119
24378649-4	2014	Here, we found firstly that staurosporine-induced apoptosis, detected as cleavage of caspase 3 is more than 3-times higher in beta-arrestin 1-lacking astrocytes than in control cells.	Staurosporine	28-41	caspase 3	Homo sapiens	85-94
24378649-4	2014	Here, we found firstly that staurosporine-induced apoptosis, detected as cleavage of caspase 3 is more than 3-times higher in beta-arrestin 1-lacking astrocytes than in control cells.	Staurosporine	28-41	arrestin beta 1	Homo sapiens	126-141
24378649-6	2014	Secondly, PAR-1 activation by thrombin protects non-silenced and beta-arrestin 1-deficient astrocytes from staurosporine-induced chemical toxicity.	Staurosporine	107-120	coagulation factor II thrombin receptor	Homo sapiens	10-15
24378649-6	2014	Secondly, PAR-1 activation by thrombin protects non-silenced and beta-arrestin 1-deficient astrocytes from staurosporine-induced chemical toxicity.	Staurosporine	107-120	coagulation factor II, thrombin	Homo sapiens	30-38
24378649-6	2014	Secondly, PAR-1 activation by thrombin protects non-silenced and beta-arrestin 1-deficient astrocytes from staurosporine-induced chemical toxicity.	Staurosporine	107-120	arrestin beta 1	Homo sapiens	65-80
24246223-5	2014	The chondrogenic effect of staurosporine was augmented when blebbistatin, an inhibitor of myosin/actin contractility, was added to the staurosporine-stimulated cultures.	Staurosporine	27-40	myosin heavy chain 14	Homo sapiens	90-96
24246223-5	2014	The chondrogenic effect of staurosporine was augmented when blebbistatin, an inhibitor of myosin/actin contractility, was added to the staurosporine-stimulated cultures.	Staurosporine	135-148	myosin heavy chain 14	Homo sapiens	90-96
24246223-7	2014	Using a selection of specific signaling pathway inhibitors, it was found that PI3K-, PKC- and p38-MAPK pathways positively regulated chondrogenesis while the ERK-pathway was found to be a negative regulator in staurosporine-induced re-differentiation, whereas down-regulation of ILK by siRNA indicated that ILK is not determining for chondrocyte re-differentiation.	Staurosporine	210-223	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	78-89
24246223-7	2014	Using a selection of specific signaling pathway inhibitors, it was found that PI3K-, PKC- and p38-MAPK pathways positively regulated chondrogenesis while the ERK-pathway was found to be a negative regulator in staurosporine-induced re-differentiation, whereas down-regulation of ILK by siRNA indicated that ILK is not determining for chondrocyte re-differentiation.	Staurosporine	210-223	mitogen-activated protein kinase 14	Homo sapiens	94-97
24246223-7	2014	Using a selection of specific signaling pathway inhibitors, it was found that PI3K-, PKC- and p38-MAPK pathways positively regulated chondrogenesis while the ERK-pathway was found to be a negative regulator in staurosporine-induced re-differentiation, whereas down-regulation of ILK by siRNA indicated that ILK is not determining for chondrocyte re-differentiation.	Staurosporine	210-223	integrin linked kinase	Homo sapiens	279-282
24246223-7	2014	Using a selection of specific signaling pathway inhibitors, it was found that PI3K-, PKC- and p38-MAPK pathways positively regulated chondrogenesis while the ERK-pathway was found to be a negative regulator in staurosporine-induced re-differentiation, whereas down-regulation of ILK by siRNA indicated that ILK is not determining for chondrocyte re-differentiation.	Staurosporine	210-223	integrin linked kinase	Homo sapiens	307-310
24426773-3	2014	METHODS: The cell survival capability of HGF and KGF in epithelial primary cultures was evaluated by using a staurosporine-induced apoptosis model.	Staurosporine	109-122	hepatocyte growth factor	Homo sapiens	41-44
24426773-3	2014	METHODS: The cell survival capability of HGF and KGF in epithelial primary cultures was evaluated by using a staurosporine-induced apoptosis model.	Staurosporine	109-122	fibroblast growth factor 7	Homo sapiens	49-52
24056996-4	2013	However, this study shows that two general kinase inhibitors, H7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine] and staurosporine (Sta), which inhibit CaMKII activity by yet another mechanism, did not interfere with GluN2B binding in vitro or within cells.	Staurosporine	118-131	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	153-159
24128664-5	2014	When exposed to staurosporine, fibroblasts from patients also showed higher caspase-3 activity; a higher percentage of cells with translocated phosphatidylserine and condensed chromatin; and higher p53 expression compared to fibroblasts from controls.	Staurosporine	16-29	caspase 3	Homo sapiens	76-85
24128664-5	2014	When exposed to staurosporine, fibroblasts from patients also showed higher caspase-3 activity; a higher percentage of cells with translocated phosphatidylserine and condensed chromatin; and higher p53 expression compared to fibroblasts from controls.	Staurosporine	16-29	tumor protein p53	Homo sapiens	198-201
24096434-5	2013	Microarray technology was initially employed to identify potential apoptosis-related genes, whose expression levels within GCs were altered by either staurosporine (STS) alone or STS in presence of ectopically over-expressed PHB.	Staurosporine	150-163	prohibitin 1	Rattus norvegicus	225-228
24096434-5	2013	Microarray technology was initially employed to identify potential apoptosis-related genes, whose expression levels within GCs were altered by either staurosporine (STS) alone or STS in presence of ectopically over-expressed PHB.	Staurosporine	165-168	prohibitin 1	Rattus norvegicus	225-228
23643731-6	2013	Following induction of mitochondrial biogenesis, L6 myoblasts displayed decreased sensitivity to apoptotic cell death as well as reduced caspase-3 and caspase-9 activation following exposure to staurosporine (STS) and C2-ceramide.	Staurosporine	194-207	caspase 3	Homo sapiens	137-146
23643731-6	2013	Following induction of mitochondrial biogenesis, L6 myoblasts displayed decreased sensitivity to apoptotic cell death as well as reduced caspase-3 and caspase-9 activation following exposure to staurosporine (STS) and C2-ceramide.	Staurosporine	194-207	caspase 9	Homo sapiens	151-160
23643731-6	2013	Following induction of mitochondrial biogenesis, L6 myoblasts displayed decreased sensitivity to apoptotic cell death as well as reduced caspase-3 and caspase-9 activation following exposure to staurosporine (STS) and C2-ceramide.	Staurosporine	209-212	caspase 3	Homo sapiens	137-146
23643731-6	2013	Following induction of mitochondrial biogenesis, L6 myoblasts displayed decreased sensitivity to apoptotic cell death as well as reduced caspase-3 and caspase-9 activation following exposure to staurosporine (STS) and C2-ceramide.	Staurosporine	209-212	caspase 9	Homo sapiens	151-160
24512015-4	2014	However, EPO increased C6 cell viability by exerting cell protective effect against staurosporine stimulation.	Staurosporine	84-97	erythropoietin	Homo sapiens	9-12
24664770-10	2014	Staurosporine has been shown in our differentiation assay to simultaneously increase the number of rhodopsin positive objects while decreasing the mean rhodopsin intensity and punctate rhodopsin fluorescent objects.	Staurosporine	0-13	rhodopsin	Mus musculus	99-108
24664770-10	2014	Staurosporine has been shown in our differentiation assay to simultaneously increase the number of rhodopsin positive objects while decreasing the mean rhodopsin intensity and punctate rhodopsin fluorescent objects.	Staurosporine	0-13	rhodopsin	Mus musculus	152-161
24664770-10	2014	Staurosporine has been shown in our differentiation assay to simultaneously increase the number of rhodopsin positive objects while decreasing the mean rhodopsin intensity and punctate rhodopsin fluorescent objects.	Staurosporine	0-13	rhodopsin	Mus musculus	152-161
24870760-0	2014	Staurosporine induced apoptosis rapidly downregulates TDP- 43 in glioma cells.	Staurosporine	0-13	TAR DNA binding protein	Homo sapiens	54-61
24870760-3	2014	Here we report that staurosporine (STS) induced apoptosis in U87 glioma cells is associated with rapid downregulation of TDP-43 at both mRNA and protein levels.	Staurosporine	20-33	TAR DNA binding protein	Homo sapiens	121-127
24870760-3	2014	Here we report that staurosporine (STS) induced apoptosis in U87 glioma cells is associated with rapid downregulation of TDP-43 at both mRNA and protein levels.	Staurosporine	35-38	TAR DNA binding protein	Homo sapiens	121-127
24797594-5	2014	RESULTS: The inhibition of phospholipase C or IP3 receptor antagonist or phosphoinositid signal transduction antagonist produced cell death and suppressed neurite outgrowth by staurosporine in PC12 cells.	Staurosporine	176-189	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	46-58
23701546-6	2014	The results show correlation between the protein expression of the Kv1.1 and Kv1.3 channels and susceptibility to death upon treatment with staurosporine, C2-ceramide and cisplatin.	Staurosporine	140-153	potassium voltage-gated channel subfamily A member 1	Homo sapiens	67-72
23701546-6	2014	The results show correlation between the protein expression of the Kv1.1 and Kv1.3 channels and susceptibility to death upon treatment with staurosporine, C2-ceramide and cisplatin.	Staurosporine	140-153	potassium voltage-gated channel subfamily A member 3	Homo sapiens	77-82
24501773-4	2014	c-Src was inhibited by Dasatinib, EGF receptor by Gefitinib, protein kinase C by staurosporine, protein kinase A by RpcAMPs and PTP1B by its specific inhibitor.	Staurosporine	81-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-5
24136992-4	2014	Pharmacological analysis using staurosporine-like indolocarbazole and bisindolylmaleimide compounds suggested that the phorbol ester- and receptor agonist-induced activation of NHE1 occurs through a protein kinase C-independent mechanism.	Staurosporine	31-44	solute carrier family 9 member A1	Homo sapiens	177-181
24136992-6	2014	Furthermore, in addition to phorbol esters and a receptor agonist, okadaic acid and hyperosmotic stress, which are known to activate NHE1 through unknown mechanisms, were found to promote membrane association of the LID concomitant with NHE1 activation; these effects were inhibited by staurosporine, as well as by a mutation in the LID.	Staurosporine	286-299	solute carrier family 9 member A1	Homo sapiens	133-137
24056996-4	2013	However, this study shows that two general kinase inhibitors, H7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine] and staurosporine (Sta), which inhibit CaMKII activity by yet another mechanism, did not interfere with GluN2B binding in vitro or within cells.	Staurosporine	118-131	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	218-224
24056996-4	2013	However, this study shows that two general kinase inhibitors, H7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine] and staurosporine (Sta), which inhibit CaMKII activity by yet another mechanism, did not interfere with GluN2B binding in vitro or within cells.	Staurosporine	133-136	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	153-159
24056996-4	2013	However, this study shows that two general kinase inhibitors, H7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine] and staurosporine (Sta), which inhibit CaMKII activity by yet another mechanism, did not interfere with GluN2B binding in vitro or within cells.	Staurosporine	133-136	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	218-224
24056996-5	2013	In contrast to a previous report, we found that Sta, like H7, inhibited CaMKII in an ATP-competitive manner.	Staurosporine	48-51	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	72-78
24056996-7	2013	H7 (700 microM) and Sta (2 microM) efficiently blocked enzymatic activity of CaMKII, both in vitro and within cells.	Staurosporine	20-23	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	77-83
24282237-6	2013	Post-anoxia MEND is ablated in DHHC5-deficient hearts, inhibited by cyclosporine A (CsA) and adenosine, promoted by staurosporine (STS), reduced in hearts lacking PLM, and correlates with impaired post-anoxia contractile function.	Staurosporine	116-129	zinc finger DHHC-type palmitoyltransferase 5	Homo sapiens	31-36
23813077-9	2013	After treating cells with staurosporine or anti-human CD95 for 16 h, the apoptotic cell percentage of HuT 78, CCRF-CEM, PC-3 and Ramos cells were 36 %+/-3 %, 24 %+/-4 %, 12 %+/-2 %, 18 %+/-4 % for staurosporine, and 63 %+/-2 %, 45 %+/-1 %, 3 %+/-3 %, 27 %+/-12 % for anti-human CD95, respectively.	Staurosporine	26-39	Fas cell surface death receptor	Homo sapiens	278-282
23813077-9	2013	After treating cells with staurosporine or anti-human CD95 for 16 h, the apoptotic cell percentage of HuT 78, CCRF-CEM, PC-3 and Ramos cells were 36 %+/-3 %, 24 %+/-4 %, 12 %+/-2 %, 18 %+/-4 % for staurosporine, and 63 %+/-2 %, 45 %+/-1 %, 3 %+/-3 %, 27 %+/-12 % for anti-human CD95, respectively.	Staurosporine	197-210	Fas cell surface death receptor	Homo sapiens	54-58
24404591-3	2013	After 1 h, these processes were suppressed by PKC inhibitors staurosporine, GF 109203X and chelerythrine, but increased by PKC activator PMA.	Staurosporine	61-74	protein kinase C, alpha	Rattus norvegicus	46-49
24282237-6	2013	Post-anoxia MEND is ablated in DHHC5-deficient hearts, inhibited by cyclosporine A (CsA) and adenosine, promoted by staurosporine (STS), reduced in hearts lacking PLM, and correlates with impaired post-anoxia contractile function.	Staurosporine	131-134	zinc finger DHHC-type palmitoyltransferase 5	Homo sapiens	31-36
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	265-278	caspase 8	Mus musculus	45-54
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	265-278	interleukin 1 beta	Mus musculus	78-86
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	265-278	toll-like receptor 4	Mus musculus	181-185
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	280-283	caspase 8	Mus musculus	45-54
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	280-283	interleukin 1 beta	Mus musculus	78-86
24078693-2	2013	We found a heretofore unappreciated role for caspase-8 as a major pathway for IL-1beta processing and release in murine bone marrow-derived dendritic cells (BMDC) costimulated with TLR4 agonists and proapoptotic chemotherapeutic agents such as doxorubicin (Dox) or staurosporine (STS).	Staurosporine	280-283	toll-like receptor 4	Mus musculus	181-185
24023368-5	2013	In neurons, both PHLPP1 KD and experimental PHLPP inhibitors activated AKT and ameliorated staurosporine (STS)-induced cell death.	Staurosporine	91-104	PH domain and leucine rich repeat protein phosphatase 1	Rattus norvegicus	17-23
24023368-5	2013	In neurons, both PHLPP1 KD and experimental PHLPP inhibitors activated AKT and ameliorated staurosporine (STS)-induced cell death.	Staurosporine	91-104	PH domain and leucine rich repeat protein phosphatase 1	Rattus norvegicus	17-22
24023368-5	2013	In neurons, both PHLPP1 KD and experimental PHLPP inhibitors activated AKT and ameliorated staurosporine (STS)-induced cell death.	Staurosporine	106-109	PH domain and leucine rich repeat protein phosphatase 1	Rattus norvegicus	17-23
24023368-5	2013	In neurons, both PHLPP1 KD and experimental PHLPP inhibitors activated AKT and ameliorated staurosporine (STS)-induced cell death.	Staurosporine	106-109	PH domain and leucine rich repeat protein phosphatase 1	Rattus norvegicus	17-22
23792959-3	2013	Here, we report the 2.8 A resolution crystal structure of human IKKbeta (hIKKbeta), which is partially phosphorylated and bound to the staurosporine analog K252a.	Staurosporine	135-148	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	73-81
24125407-7	2013	uPA attenuated MonoMac6 (MM6) macrophage-like cell line apoptosis induced by oxidized LDL (Ox-LDL) and by thapsigargin (inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPase), but not by staurosporine (protein kinase inhibitor), suggesting that uPA antiapoptotic activity is Ca(2+)-independent, but involves a kinase activation.	Staurosporine	188-201	plasminogen activator, urokinase	Homo sapiens	0-3
24116255-0	2013	Correction: Magmas Overexpression Inhibits Staurosporine Induced Apoptosis in Rat Pituitary Adenoma Cell Lines.	Staurosporine	43-56	mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction, pseudogene 1	Rattus norvegicus	12-18
23902766-6	2013	Also, MMP-1 promoted MLE12 cell migration through collagen I, accelerated wound closing, and protected cells from staurosporine- and bleomycin-induced apoptosis compared with mock cells (p &lt; 0.01).	Staurosporine	114-127	matrix metallopeptidase 13	Mus musculus	6-11
23831818-4	2013	Work with primary cultures of rat heart cells revealed that StAR is induced in fibroblasts responding to proapoptotic treatments with hydrogen peroxide or the kinase inhibitor staurosporine (STS).	Staurosporine	176-189	steroidogenic acute regulatory protein	Rattus norvegicus	60-64
23831818-4	2013	Work with primary cultures of rat heart cells revealed that StAR is induced in fibroblasts responding to proapoptotic treatments with hydrogen peroxide or the kinase inhibitor staurosporine (STS).	Staurosporine	191-194	steroidogenic acute regulatory protein	Rattus norvegicus	60-64
23977080-3	2013	Rat hippocampal neurons pretreated with purified CPE protected the cells against hydrogen peroxide-, staurosporine- and glutamate-induced cell death.	Staurosporine	101-114	carboxypeptidase E	Rattus norvegicus	49-52
23792959-3	2013	Here, we report the 2.8 A resolution crystal structure of human IKKbeta (hIKKbeta), which is partially phosphorylated and bound to the staurosporine analog K252a.	Staurosporine	135-148	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	64-71
24091666-0	2013	Porcine JAB1 significantly enhances apoptosis induced by staurosporine.	Staurosporine	57-70	COP9 signalosome subunit 5	Homo sapiens	8-12
24091666-11	2013	Flow cytometric analysis proved that pJAB1 significantly enhanced apoptosis induced by staurosporine, which at least partially depended on the activation of caspase-9 and caspase-3.	Staurosporine	87-100	caspase 9	Homo sapiens	157-166
24091666-11	2013	Flow cytometric analysis proved that pJAB1 significantly enhanced apoptosis induced by staurosporine, which at least partially depended on the activation of caspase-9 and caspase-3.	Staurosporine	87-100	caspase 3	Homo sapiens	171-180
23722650-0	2013	Staurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner.	Staurosporine	0-13	checkpoint kinase 1	Homo sapiens	60-64
23722650-0	2013	Staurosporine is chemoprotective by inducing G1 arrest in a Chk1- and pRb-dependent manner.	Staurosporine	0-13	RB transcriptional corepressor 1	Homo sapiens	70-73
24069211-12	2013	Increased Rgl2 expression in cultured cardiomyocytes stimulated Ral activation and inhibited staurosporine-induced apoptosis via increased activation of PI3-kinase.	Staurosporine	93-106	ral guanine nucleotide dissociation stimulator-like 2	Mus musculus	10-14
24069394-0	2013	Magmas overexpression inhibits staurosporine induced apoptosis in rat pituitary adenoma cell lines.	Staurosporine	31-44	presequence translocase associated motor 16	Rattus norvegicus	0-6
24069394-3	2013	Here we report that Magmas is highly expressed in two out of four rat pituitary adenoma cell lines and its expression levels inversely correlate to the extent of cellular response to staurosporine in terms of apoptosis activation and cell viability.	Staurosporine	183-196	presequence translocase associated motor 16	Rattus norvegicus	20-26
24069394-4	2013	Magmas over-expression in rat GH/PRL-secreting pituitary adenoma GH4C1 cells leads to an increase in cell viability and to a reduction in staurosporine-induced apoptosis and DNA fragmentation, in parallel with the increase in Magmas protein expression.	Staurosporine	138-151	presequence translocase associated motor 16	Rattus norvegicus	0-6
24069394-5	2013	These results indicate that Magmas plays a pivotal role in response to pro-apoptotic stimuli and confirm and extend the finding that Magmas protects pituitary cells from staurosporine-induced apoptosis, suggesting its possible involvement in pituitary adenoma development.	Staurosporine	170-183	presequence translocase associated motor 16	Rattus norvegicus	133-139
23820591-6	2013	The recombinant RTB-induced production of NO, TNF-alpha and IL-6 was inhibited in the macrophages treated with the pharmacological inhibitors genistein, LY294002, staurosporine, AG490, SB203580 and BAY 11-7082, indicating the possible involvement of protein tyrosine kinases, PI3K, PKC, JAK2, p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB in the above processes.	Staurosporine	163-176	interleukin 6	Mus musculus	60-64
23859824-10	2013	Finally, mouse embryonic stem cells display caspase-dependent downregulation of CtBP1 following exposure to staurosporine, an effect that is not observed in DGCR8 knockout cells which are deficient in miRNA processing.	Staurosporine	108-121	C-terminal binding protein 1	Mus musculus	80-85
23754155-0	2013	MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability.	Staurosporine	83-96	membrane associated guanylate kinase, WW and PDZ domain containing 2	Homo sapiens	0-5
23859021-4	2013	The activity of caspases 9 and 3 following apoptosis induction treatment (staurosporine) indicated reduction of apoptosis by rProTalpha-wt but not by rProTalpha-T7A.	Staurosporine	74-87	caspase 9	Homo sapiens	16-32
23754155-0	2013	MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability.	Staurosporine	83-96	phosphatase and tensin homolog	Homo sapiens	129-133
23219599-8	2013	Par-4 phosphorylation was inhibited by the non-selective kinase inhibitor staurosporine, but not by inhibitors of ZIPK, Rho-associated kinase or protein kinase C. In addition, Par-4 phosphorylation did not occur upon addition of constitutively-active ZIPK to skinned tissue.	Staurosporine	74-87	pro-apoptotic WT1 regulator	Rattus norvegicus	0-5
23870437-15	2013	In contrast, only DC2.4 cells transduced with LVs encoding Bcl-XL and M11L were protected from effects of staurosporine (STS) treatment.	Staurosporine	106-119	BCL2-like 1	Mus musculus	59-65
23870437-15	2013	In contrast, only DC2.4 cells transduced with LVs encoding Bcl-XL and M11L were protected from effects of staurosporine (STS) treatment.	Staurosporine	121-124	BCL2-like 1	Mus musculus	59-65
23874579-7	2013	Renal cells, adapted to high NaCl osmotic stress, express a high level of VIM IV (the form with the highest molecular weight), besides the three other forms, and exhibit higher resistance to apoptotic induction with TNF-alpha or staurosporin compared to the control.	Staurosporine	229-241	vimentin	Homo sapiens	74-77
23986809-3	2013	We recently observed that staurosporine and related analogs: 7-oxostaurosporine, UCN-01 and UCN-02, long known as relatively non-specific protein kinase inhibitors, block endosomal sorting and recycling of phosphatidylserine, resulting in redistribution of phosphatidylserine to endosomes and endomembranes with concomitant mislocalization of K-Ras.	Staurosporine	26-39	KRAS proto-oncogene, GTPase	Homo sapiens	343-348
23667252-8	2013	This interaction is functionally relevant because YAP binding to dendrin reduces dendrin-dependent, staurosporine-induced apoptosis in co-transfected HEK293 cells.	Staurosporine	100-113	Yes1 associated transcriptional regulator	Homo sapiens	50-53
23798729-6	2013	Drp1-x01 stabilized and bundled microtubules and attenuated staurosporine-induced mitochondrial fragmentation and apoptosis.	Staurosporine	60-73	dynamin 1 like	Homo sapiens	0-4
23840623-6	2013	In both 2-dimensional and 3-dimensional growth conditions, BST2-silenced tumor cells displayed an enhancement in tamoxifen or staurosporine-induced apoptotic cell death together with a reduction in the S-phase fraction compared to BST2 overexpressing counterparts.	Staurosporine	126-139	bone marrow stromal cell antigen 2	Homo sapiens	59-63
23667252-10	2013	It also increases staurosporine-induced caspase-3/7 activity, which is rescued by dendrin depletion in YAP knockdown cells.	Staurosporine	18-31	caspase 3	Homo sapiens	40-49
23667252-10	2013	It also increases staurosporine-induced caspase-3/7 activity, which is rescued by dendrin depletion in YAP knockdown cells.	Staurosporine	18-31	Yes1 associated transcriptional regulator	Homo sapiens	103-106
23323619-0	2013	Modulation of staurosporine-activated volume-sensitive outwardly rectifying Cl- channel by PI3K/Akt in cardiomyocytes.	Staurosporine	14-27	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
23734232-7	2013	CXCL12-induced phosphorylation at S346/347 was staurosporine-insensitive and mediated by GRK2/3.	Staurosporine	47-60	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
23467693-6	2013	Furthermore, in this study, we showed that PARG-siRNA enhanced cell death induced by staurosporine (STS).	Staurosporine	85-98	poly(ADP-ribose) glycohydrolase	Homo sapiens	43-47
23467693-6	2013	Furthermore, in this study, we showed that PARG-siRNA enhanced cell death induced by staurosporine (STS).	Staurosporine	100-103	poly(ADP-ribose) glycohydrolase	Homo sapiens	43-47
23627909-14	2013	The decrease in CX3CL1 expression by ET-1 was inhibited by cycloheximide, Ca(2+) chelation and staurosporine.	Staurosporine	95-108	C-X3-C motif chemokine ligand 1	Rattus norvegicus	16-22
23627909-14	2013	The decrease in CX3CL1 expression by ET-1 was inhibited by cycloheximide, Ca(2+) chelation and staurosporine.	Staurosporine	95-108	endothelin 1	Rattus norvegicus	37-41
23567017-3	2013	Here we examined the expression of PHB and its regulation by FSH in vitro and studied the role of PHB in the regulation of apoptosis and steroidogenesis in response to the apoptosis inducer staurosporine (STS) and to FSH, respectively.	Staurosporine	190-203	prohibitin 1	Rattus norvegicus	98-101
23566798-8	2013	Staurosporine, a more general phosphorylation inhibitor, also reduced the levels of MRLC phosphorylation and caused anaphase chromosomes to stop or slow.	Staurosporine	0-13	spaghetti squash	Drosophila melanogaster	84-88
23566798-9	2013	The effects of staurosporine on chromosome movements were not reversed by Calyculin A, confirming that another phosphorylation pathway is involved in phosphorylation of spindle myosin.	Staurosporine	15-28	spaghetti squash	Drosophila melanogaster	177-183
23333591-3	2013	STS treatment, without T. gondii infection, reduced the viability of THP-1 cells in proportion to STS concentration and triggered many cellular death events such as caspase-3 and -9 activation, Bax translocation, cytochrome c release from host cell mitochondria into cytosol, and PARP cleavage in the host cell.	Staurosporine	0-3	caspase 3	Homo sapiens	165-181
23333591-3	2013	STS treatment, without T. gondii infection, reduced the viability of THP-1 cells in proportion to STS concentration and triggered many cellular death events such as caspase-3 and -9 activation, Bax translocation, cytochrome c release from host cell mitochondria into cytosol, and PARP cleavage in the host cell.	Staurosporine	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	194-197
23333591-3	2013	STS treatment, without T. gondii infection, reduced the viability of THP-1 cells in proportion to STS concentration and triggered many cellular death events such as caspase-3 and -9 activation, Bax translocation, cytochrome c release from host cell mitochondria into cytosol, and PARP cleavage in the host cell.	Staurosporine	0-3	cytochrome c, somatic	Homo sapiens	213-225
23333591-3	2013	STS treatment, without T. gondii infection, reduced the viability of THP-1 cells in proportion to STS concentration and triggered many cellular death events such as caspase-3 and -9 activation, Bax translocation, cytochrome c release from host cell mitochondria into cytosol, and PARP cleavage in the host cell.	Staurosporine	0-3	poly(ADP-ribose) polymerase 1	Homo sapiens	280-284
23097134-0	2013	Sodium valproate potentiates staurosporine-induced apoptosis in neuroblastoma cells via Akt/survivin independently of HDAC inhibition.	Staurosporine	29-42	AKT serine/threonine kinase 1	Homo sapiens	88-91
23097134-4	2013	Using human neuroblastoma cell lines, SK-N-MC, SH-SY5Y, and SK-N-SH, we show that non-toxic dose (2 mM) of VPA enhanced staurosporine (STS)-induced cell death as assessed by MTT assay, PARP cleavage, hypodiploidy, and caspase 3 activity.	Staurosporine	120-133	poly(ADP-ribose) polymerase 1	Homo sapiens	185-189
23097134-4	2013	Using human neuroblastoma cell lines, SK-N-MC, SH-SY5Y, and SK-N-SH, we show that non-toxic dose (2 mM) of VPA enhanced staurosporine (STS)-induced cell death as assessed by MTT assay, PARP cleavage, hypodiploidy, and caspase 3 activity.	Staurosporine	120-133	caspase 3	Homo sapiens	218-227
23097134-4	2013	Using human neuroblastoma cell lines, SK-N-MC, SH-SY5Y, and SK-N-SH, we show that non-toxic dose (2 mM) of VPA enhanced staurosporine (STS)-induced cell death as assessed by MTT assay, PARP cleavage, hypodiploidy, and caspase 3 activity.	Staurosporine	135-138	poly(ADP-ribose) polymerase 1	Homo sapiens	185-189
23097134-4	2013	Using human neuroblastoma cell lines, SK-N-MC, SH-SY5Y, and SK-N-SH, we show that non-toxic dose (2 mM) of VPA enhanced staurosporine (STS)-induced cell death as assessed by MTT assay, PARP cleavage, hypodiploidy, and caspase 3 activity.	Staurosporine	135-138	caspase 3	Homo sapiens	218-227
23592961-6	2013	It guided further experimental investigation that showed that Bik total amount remained constant during staurosporine exposure, and suggested that Bik protein might undergo activation to induce apoptosis.	Staurosporine	104-117	BCL2-interacting killer	Mus musculus	62-65
23519123-8	2013	Our results showed that staurosporine, a non-specific inhibitor of PKC, as well as specific PKCzeta inhibitor and PKCzeta siRNA, abolished ethanol-induced CYP2E1 expression.	Staurosporine	24-37	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	155-161
23415866-4	2013	Similarly, endogenous PICOT was cleaved in cell death responses induced by staurosporine and etoposide.	Staurosporine	75-88	glutaredoxin 3	Homo sapiens	22-27
23331014-0	2013	Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.	Staurosporine	44-57	profilin 1	Homo sapiens	0-10
23307575-8	2013	KLK6 reduced the sensitivity of GBM cell lines to cytotoxic agents, including staurosporine and cisplatin, and to the current standard of patient care: radiotherapy or temozolomide alone or in combination.	Staurosporine	78-91	kallikrein related peptidase 6	Homo sapiens	0-4
23354245-0	2013	Microvascular endothelial cell hyperpermeability induced by endogenous caspase 3 activator staurosporine.	Staurosporine	91-104	caspase 3	Rattus norvegicus	71-80
23354245-2	2013	The objective of this study was to examine the action of staurosporine, a potent activator of endogenous caspase 3 on the adherens junction and the cellular pathway through which it causes possible endothelial cell barrier dysfunction.	Staurosporine	57-70	caspase 3	Rattus norvegicus	105-114
23354245-8	2013	RESULTS: Staurosporine (1 microM)-treated RLMEC monolayers showed significant increase in permeability, which was decreased by pretreatment with caspase 3 specific inhibitor, Z-DEVD-FMK (p &lt; 0.05).	Staurosporine	9-22	caspase 3	Rattus norvegicus	145-154
23354245-11	2013	Furthermore, staurosporine induced a significant increase in caspase 3 activity (p &lt; 0.05) but not cell death in RLMECs (p &lt; 0.05).	Staurosporine	13-26	caspase 3	Rattus norvegicus	61-70
23136001-4	2013	Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling analysis and caspase cleavage assays demonstrated that 1-desamino-8-d-arginine vasopressin (dDAVP) inhibited apoptosis induced by various agents (staurosporine, actinomycin D, and cycloheximide) in cultured mouse cortical collecting duct cells (mpkCCD).	Staurosporine	223-236	arginine vasopressin	Homo sapiens	156-167
23206699-6	2013	Furthermore, overexpressing the TG6 mutants sensitized cells to staurosporine-induced apoptosis by increasing the activity of caspases.	Staurosporine	64-77	transglutaminase 6	Homo sapiens	32-35
23364598-8	2013	RESULTS: Activation of TREM-1 protected monocytes from staurosporine-induced apoptosis.	Staurosporine	55-68	triggering receptor expressed on myeloid cells 1	Mus musculus	23-29
23589925-7	2013	Staurosporine (10 nM), a protein kinase C (PKC) inhibitor, reversed almost completely IP1 production, or partially for [Ca2+]i, GPI formation and AA release of this homologous desensitization effect of histamine.	Staurosporine	0-13	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	86-89
23589925-9	2013	Ten nM staurosporine completely reversed the effect of PMA on histamine-induced IP1 formation and partially on [Ca2+]i accumulation.	Staurosporine	7-20	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	80-83
23479737-5	2013	We demonstrate that IP3R1 is cleaved during staurosporine-induced apoptosis, yielding N-terminal fragments encompassing the ligand-binding domain and the majority of the central modulatory domain together with a C-terminal fragment containing the channel domain and cytosolic tail.	Staurosporine	44-57	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	20-25
23397112-0	2013	Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its mechanism in human hepatocarcinoma cell lines.	Staurosporine	47-60	DNA methyltransferase 3 beta	Homo sapiens	19-43
23313137-8	2013	Nogo-B KO MF-HSCs showed significantly increased levels of apoptotic markers, cleaved poly (ADP-ribose) polymerase, and caspase-3 and -8 (P &lt; 0.05) compared with WT MF-HSCs in response to staurosporine.	Staurosporine	191-204	reticulon 4	Mus musculus	0-6
23313137-10	2013	In LX2 cells, Nogo-B knockdown enhanced apoptosis in response to staurosporine, whereas Nogo-B overexpression inhibited apoptosis.	Staurosporine	65-78	reticulon 4	Homo sapiens	14-20
23262392-10	2013	Two PKC inhibitors (chelerythrine and staurosporine) significantly reduced basal EAAT3 activity.	Staurosporine	38-51	solute carrier family 1 member 1	Rattus norvegicus	81-86
23122728-4	2013	We detected a robust increase in calcium levels in response to staurosporine treatment in primary human fibroblasts and HeLa cells in the presence of the caspase inhibitor Z-VAD, indicating that calcium release during the initiation of apoptosis occurs independently of caspase 3.	Staurosporine	63-76	caspase 3	Homo sapiens	270-279
23122728-7	2013	Significantly, blocking IP(3) binding to the IP(3)R with an IP(3) sponge resulted in suppression of staurosporine-induced calcium release and cell death.	Staurosporine	100-113	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	45-51
23153365-0	2013	Activation of Rac1-dependent redox signaling is critically involved in staurosporine-induced neurite outgrowth in PC12 cells.	Staurosporine	71-84	Rac family small GTPase 1	Rattus norvegicus	14-18
23153365-2	2013	In the present study, we investigated whether the activation of Rac1 was responsible for the neurite outgrowth triggered by staurosporine.	Staurosporine	124-137	Rac family small GTPase 1	Rattus norvegicus	64-68
23153365-4	2013	In contrast, neurite outgrowth in response to staurosporine was accompanied by activation of Rac1, and the Rac1 inhibitor NSC23766 attenuated the staurosporine-induced neurite outgrowth in a concentration-dependent manner.	Staurosporine	46-59	Rac family small GTPase 1	Rattus norvegicus	93-97
23153365-4	2013	In contrast, neurite outgrowth in response to staurosporine was accompanied by activation of Rac1, and the Rac1 inhibitor NSC23766 attenuated the staurosporine-induced neurite outgrowth in a concentration-dependent manner.	Staurosporine	146-159	Rac family small GTPase 1	Rattus norvegicus	93-97
23153365-4	2013	In contrast, neurite outgrowth in response to staurosporine was accompanied by activation of Rac1, and the Rac1 inhibitor NSC23766 attenuated the staurosporine-induced neurite outgrowth in a concentration-dependent manner.	Staurosporine	146-159	Rac family small GTPase 1	Rattus norvegicus	107-111
23153365-5	2013	In addition, suppression of Rac1 activity by expression of the dominant negative mutant Rac1N17 also blocked the staurosporine-induced morphological differentiation of PC12 cells.	Staurosporine	113-126	Rac family small GTPase 1	Rattus norvegicus	28-32
23153365-8	2013	These results indicate that activation of Rac1, which leads to ROS generation, is required for neurite outgrowth induced by staurosporine in PC12 cells.	Staurosporine	124-137	Rac family small GTPase 1	Rattus norvegicus	42-46
23323619-2	2013	This study was designed to examine the impact of the pro-apoptotic stimulus staurosporine (STS) on the volume-sensitive outwardly rectifying Cl- current (I(Cl,Vol)) in cardiomyocytes and possible regulatory mechanism involved with a focus on phosphatidylinositol-3 kinase (PI3K)/Akt.	Staurosporine	76-89	AKT serine/threonine kinase 1	Rattus norvegicus	279-282
23323619-2	2013	This study was designed to examine the impact of the pro-apoptotic stimulus staurosporine (STS) on the volume-sensitive outwardly rectifying Cl- current (I(Cl,Vol)) in cardiomyocytes and possible regulatory mechanism involved with a focus on phosphatidylinositol-3 kinase (PI3K)/Akt.	Staurosporine	91-94	AKT serine/threonine kinase 1	Rattus norvegicus	279-282
23323619-9	2013	Taken together, our data depicted staurosporine is capable of activating I(Cl,Vol) channel in cardiomyocytes via possibly a PI3K/Akt-dependent mechanism.	Staurosporine	34-47	AKT serine/threonine kinase 1	Rattus norvegicus	129-132
25033808-4	2013	Here we summarize the biochemistry and biology of three classes of compound identified by this screening method that inhibit K-Ras PM targeting: staurosporine and analogs, fendiline, and metformin.	Staurosporine	145-158	KRAS proto-oncogene, GTPase	Homo sapiens	125-130
24058797-7	2013	However, the mutant followed changes in ligand-induced receptor activation more slowly than the wild-type molecule, as demonstrated by its elevated phospho-STAT1 concentration following addition of the kinase inhibitor staurosporine to interferon-pretreated cells.	Staurosporine	219-232	signal transducer and activator of transcription 1	Homo sapiens	156-161
23009217-6	2013	Similar effects were observed upon inhibition of the oncogenic receptor tyrosine kinase FLT3 using the staurosporine derivate PKC412, implicating a role for FLT3 as an upstream regulator of Ezrin.	Staurosporine	103-116	fms related receptor tyrosine kinase 3	Homo sapiens	88-92
23009217-6	2013	Similar effects were observed upon inhibition of the oncogenic receptor tyrosine kinase FLT3 using the staurosporine derivate PKC412, implicating a role for FLT3 as an upstream regulator of Ezrin.	Staurosporine	103-116	fms related receptor tyrosine kinase 3	Homo sapiens	157-161
23671839-7	2013	The purified SP2 was then added to a culture medium for human umbilical vein ECs (HUVECs), which were exposed to staurosporine.	Staurosporine	113-126	Sp2 transcription factor	Homo sapiens	13-16
23671839-9	2013	Furthermore, both ELISA and flow cytometry results indicated that SP2 has anti-apoptotic effects on staurosporine-induced HUVEC apoptosis.	Staurosporine	100-113	sex-specific storage-protein 2	Bombyx mori	66-69
23001711-6	2013	Staurosporine, a protein kinase inhibitor, significantly reduced the interaction between MARK2 and tau, and also phosphorylation of tau at Ser(262).	Staurosporine	0-13	microtubule affinity regulating kinase 2	Homo sapiens	89-94
23001711-6	2013	Staurosporine, a protein kinase inhibitor, significantly reduced the interaction between MARK2 and tau, and also phosphorylation of tau at Ser(262).	Staurosporine	0-13	microtubule associated protein tau	Homo sapiens	99-102
23459311-6	2013	HGF treatment of an alveolar epithelial cell line not only induced proliferation and scattering of the cells but also conferred protection against staurosporine-induced apoptosis, properties critical for alveolar septation.	Staurosporine	147-160	hepatocyte growth factor	Mus musculus	0-3
22846225-13	2013	(2012) had also claimed that staurosporine, a general kinase inhibitor that does not effectively inhibit PKMzeta biochemically in vitro, nonetheless indirectly blocked the PKMzeta fusion protein overexpressed in cultured cells by inhibiting phosphoinositide-dependent protein kinase-1 (PDK1).	Staurosporine	29-42	pyruvate dehydrogenase kinase 1	Homo sapiens	241-284
22846225-13	2013	(2012) had also claimed that staurosporine, a general kinase inhibitor that does not effectively inhibit PKMzeta biochemically in vitro, nonetheless indirectly blocked the PKMzeta fusion protein overexpressed in cultured cells by inhibiting phosphoinositide-dependent protein kinase-1 (PDK1).	Staurosporine	29-42	pyruvate dehydrogenase kinase 1	Homo sapiens	286-290
23124205-4	2012	Staurosporines are more active against K-Ras than H-Ras.	Staurosporine	0-14	KRAS proto-oncogene, GTPase	Homo sapiens	39-44
23383327-8	2013	We further observed in staurosporine-treated photoreceptor-like 661W cells stably overexpressing alphaA- or alphaB-crystallin that Bax-dependent apoptosis and caspase activation were inhibited.	Staurosporine	23-36	crystallin, alpha B	Mus musculus	108-125
23383327-8	2013	We further observed in staurosporine-treated photoreceptor-like 661W cells stably overexpressing alphaA- or alphaB-crystallin that Bax-dependent apoptosis and caspase activation were inhibited.	Staurosporine	23-36	BCL2-associated X protein	Mus musculus	131-134
23349925-8	2013	Blockade of SIK activity with a low concentration of staurosporine abolished BDNF-induced phosphorylation and nuclear export of HDAC5 in cortical neurons.	Staurosporine	53-66	brain-derived neurotrophic factor	Rattus norvegicus	77-81
23349925-8	2013	Blockade of SIK activity with a low concentration of staurosporine abolished BDNF-induced phosphorylation and nuclear export of HDAC5 in cortical neurons.	Staurosporine	53-66	histone deacetylase 5	Rattus norvegicus	128-133
23349925-9	2013	Importantly, stimulation of HDAC5 phosphorylation and nuclear export by BDNF is accompanied by the activation of MEF2-mediated transcription, an effect that is suppressed by staurosporine.	Staurosporine	174-187	histone deacetylase 5	Rattus norvegicus	28-33
23349925-9	2013	Importantly, stimulation of HDAC5 phosphorylation and nuclear export by BDNF is accompanied by the activation of MEF2-mediated transcription, an effect that is suppressed by staurosporine.	Staurosporine	174-187	brain-derived neurotrophic factor	Rattus norvegicus	72-76
23349925-10	2013	Consistent with these data, BDNF induces the expression of the MEF2 target genes Arc and Nur77, in a staurosporine-sensitive manner.	Staurosporine	101-114	brain-derived neurotrophic factor	Rattus norvegicus	28-32
23349925-10	2013	Consistent with these data, BDNF induces the expression of the MEF2 target genes Arc and Nur77, in a staurosporine-sensitive manner.	Staurosporine	101-114	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	89-94
23124205-4	2012	Staurosporines are more active against K-Ras than H-Ras.	Staurosporine	0-14	HRas proto-oncogene, GTPase	Homo sapiens	50-55
23124205-8	2012	Staurosporines selectively abrogate K-Ras signaling and proliferation of K-Ras-transformed cells.	Staurosporine	0-14	KRAS proto-oncogene, GTPase	Homo sapiens	36-41
23124205-8	2012	Staurosporines selectively abrogate K-Ras signaling and proliferation of K-Ras-transformed cells.	Staurosporine	0-14	KRAS proto-oncogene, GTPase	Homo sapiens	73-78
22841891-5	2012	Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T).	Staurosporine	13-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-79
23216709-11	2012	The inhibitory effect of DHT on ApoM secretion was not blocked by the classical androgen receptor blocker flutamide but by an antagonist of PKC, Staurosporine.	Staurosporine	145-158	apolipoprotein M	Homo sapiens	32-36
22775778-7	2012	The insulin secretagogue effect of OSA  was dependent, in part, on protein kinase activation since incubating mouse or human islets with staurosporine, a general protein kinase inhibitor, resulted in partial inhibition of OSA -induced insulin secretion.	Staurosporine	137-150	insulin	Homo sapiens	4-11
22775778-7	2012	The insulin secretagogue effect of OSA  was dependent, in part, on protein kinase activation since incubating mouse or human islets with staurosporine, a general protein kinase inhibitor, resulted in partial inhibition of OSA -induced insulin secretion.	Staurosporine	137-150	insulin	Homo sapiens	235-242
23088714-4	2012	HFDP cell incubation with staurosporine caused apoptosis, which was completely inhibited by exposure to rutin (2.2 muM), spermidine (1 muM) and zeaxanthin (80 muM).	Staurosporine	26-39	latexin	Homo sapiens	115-118
23088714-4	2012	HFDP cell incubation with staurosporine caused apoptosis, which was completely inhibited by exposure to rutin (2.2 muM), spermidine (1 muM) and zeaxanthin (80 muM).	Staurosporine	26-39	latexin	Homo sapiens	135-138
23088714-4	2012	HFDP cell incubation with staurosporine caused apoptosis, which was completely inhibited by exposure to rutin (2.2 muM), spermidine (1 muM) and zeaxanthin (80 muM).	Staurosporine	26-39	latexin	Homo sapiens	135-138
22841891-5	2012	Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T).	Staurosporine	13-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	81-85
22841891-5	2012	Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T).	Staurosporine	13-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
22841891-5	2012	Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T).	Staurosporine	13-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
22841891-5	2012	Furthermore, staurosporine treatment resulted in decreased acetylcholinesterase (AChE) enzymatic activity and decreased protein levels of the AChE splice variant tailed AChE (AChE-T).	Staurosporine	13-26	acetylcholinesterase (Cartwright blood group)	Homo sapiens	142-146
22841891-9	2012	The effects of various additional phosphorylation inhibitors on AChE activity suggest that these unexpected cholinergic effects, firstly, are linked to the impact of staurosporine on phosphorylation and, secondly, reveal themselves in a first phase of cellular adaption that precedes neurotoxicity and subsequent cell death.	Staurosporine	166-179	acetylcholinesterase (Cartwright blood group)	Homo sapiens	64-68
23015448-4	2012	Here, we report that apoptotic stimuli (staurosporine or C2-ceramide) reciprocally altered Bcl-x splicing in neural cells, decreasing Bcl-x(L) while increasing Bcl-x(S).	Staurosporine	40-53	Bcl2-like 1	Rattus norvegicus	91-96
22966160-11	2012	Finally, the general kinase inhibitor staurosporine completely inhibited the IP(3)-induced stimulation of NBCe1-C.	Staurosporine	38-51	solute carrier family 4 member 4 L homeolog	Xenopus laevis	106-111
22555455-5	2012	In addition, overexpression of DJ-1 Nt in different cell lines leads to a loss of clonogenic potential and sensitizes to staurosporin and 1-methyl-4-phenylpyridinium (MPP+)-mediated caspase activation and apoptosis.	Staurosporine	121-133	Parkinsonism associated deglycase	Homo sapiens	31-35
22595756-0	2012	SIRT3 protects from hypoxia and staurosporine-mediated cell death by maintaining mitochondrial membrane potential and intracellular pH.	Staurosporine	32-45	sirtuin 3	Homo sapiens	0-5
22595756-2	2012	Here, we show that in mammalian cells subjected to hypoxia and staurosporine treatment SIRT3 prevents loss of mitochondrial membrane potential (DeltaPsi(mt)), intracellular acidification and reactive oxygen species accumulation.	Staurosporine	63-76	sirtuin 3	Homo sapiens	87-92
23063362-4	2012	Through a systematic screen of inducers of cellular stress, we found that PGRN S116X neurons, but not sporadic FTD neurons, exhibited increased sensitivity to staurosporine and other kinase inhibitors.	Staurosporine	159-172	granulin precursor	Homo sapiens	74-78
23077721-7	2012	Using this assay, we discovered that staurosporine increased CHT LV-AA choline uptake activity, an effect mediated by a decrease in choline K(M) with no change in V(max).	Staurosporine	37-50	solute carrier family 5 member 7	Homo sapiens	61-64
23077721-9	2012	Surprisingly, staurosporine reduced choline-induced membrane depolarization, suggesting that increased substrate coupling to ion gradients, arising at the expense of nonstoichiometric ion flow, accompanies a shift of CHT to a higher-affinity state.	Staurosporine	14-27	solute carrier family 5 member 7	Homo sapiens	217-220
22743255-9	2012	Nevertheless, through alpha receptor NE could promote the phosphorylation of PKC and PKC inhibitor staurosporine could counteract NE"s enhancive effect on production of NO and iNOS of macrophages.	Staurosporine	99-112	nitric oxide synthase 2	Rattus norvegicus	176-180
22802092-5	2012	The potentiation of UPR was also detected in HEK293/tau cells treated with other ER stress inducers, including staurosporine, camptothecin and hydrogen peroxide, in which a suppressed apoptosis was also shown.	Staurosporine	111-124	microtubule associated protein tau	Homo sapiens	52-55
22484496-3	2012	When ectopically expressed, Mfn1 inhibited the amino-terminal activation, but not the mitochondrial translocation, of Bax during staurosporine-induced apoptosis; overexpression of Mfn2 had no effect.	Staurosporine	129-142	mitofusin 1	Homo sapiens	28-32
22484496-5	2012	Furthermore, staurosporine-induced amino-terminal activation of Bax was significantly delayed in Mfn1-shRNA transfected (Mfn1-depleted) HeLa cells compared to cells transfected with control shRNA.	Staurosporine	13-26	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
22484496-5	2012	Furthermore, staurosporine-induced amino-terminal activation of Bax was significantly delayed in Mfn1-shRNA transfected (Mfn1-depleted) HeLa cells compared to cells transfected with control shRNA.	Staurosporine	13-26	mitofusin 1	Homo sapiens	97-101
22484496-5	2012	Furthermore, staurosporine-induced amino-terminal activation of Bax was significantly delayed in Mfn1-shRNA transfected (Mfn1-depleted) HeLa cells compared to cells transfected with control shRNA.	Staurosporine	13-26	mitofusin 1	Homo sapiens	121-125
22742926-0	2012	Axin expression reduces staurosporine-induced mitochondria-mediated cell death in HeLa cells.	Staurosporine	24-37	axin 1	Homo sapiens	0-4
22742926-7	2012	Compared to STS-treated control cells (HeLa-EV), HeLa-Axin cells had less STS-induced cytotoxicity and reduced caspase-3 activation and PARP cleavage.	Staurosporine	12-15	axin 1	Homo sapiens	54-58
23015448-4	2012	Here, we report that apoptotic stimuli (staurosporine or C2-ceramide) reciprocally altered Bcl-x splicing in neural cells, decreasing Bcl-x(L) while increasing Bcl-x(S).	Staurosporine	40-53	Bcl2-like 1	Rattus norvegicus	134-142
23015448-4	2012	Here, we report that apoptotic stimuli (staurosporine or C2-ceramide) reciprocally altered Bcl-x splicing in neural cells, decreasing Bcl-x(L) while increasing Bcl-x(S).	Staurosporine	40-53	Bcl2-like 1	Rattus norvegicus	134-139
22893598-3	2012	Hit compounds that displace ANS directly or indirectly from CDK2 are readily classified as ATP site binders or allosteric ligands through the use of staurosporine, which blocks the ATP site without displacing ANS.	Staurosporine	149-162	cyclin dependent kinase 2	Homo sapiens	60-64
23049497-3	2012	Our previous results showed that thymocytes isolated from stefin B-deficient mice are more sensitive to apoptosis induced by the protein kinase C (PKC) inhibitor staurosporin (STS) than the wild-type control cells.	Staurosporine	162-174	cystatin B	Mus musculus	58-66
22884615-6	2012	Also, 27-hydroxycholesterol significantly decreased the staurosporine-mediated induction of caspase-3 and -7, known to be important in apoptotic events.	Staurosporine	56-69	caspase 3	Homo sapiens	92-108
22388352-6	2012	Importantly, in a set of human cancer cells with Src-, Kras- or BRAF-dependent activation of Erk1/2, resistances to staurosporine or thapsigargin were also shown to depend on Bik degradation rate via a similar mechanism.	Staurosporine	116-129	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-52
22388352-6	2012	Importantly, in a set of human cancer cells with Src-, Kras- or BRAF-dependent activation of Erk1/2, resistances to staurosporine or thapsigargin were also shown to depend on Bik degradation rate via a similar mechanism.	Staurosporine	116-129	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	64-68
22388352-6	2012	Importantly, in a set of human cancer cells with Src-, Kras- or BRAF-dependent activation of Erk1/2, resistances to staurosporine or thapsigargin were also shown to depend on Bik degradation rate via a similar mechanism.	Staurosporine	116-129	mitogen-activated protein kinase 3	Homo sapiens	93-99
22388352-6	2012	Importantly, in a set of human cancer cells with Src-, Kras- or BRAF-dependent activation of Erk1/2, resistances to staurosporine or thapsigargin were also shown to depend on Bik degradation rate via a similar mechanism.	Staurosporine	116-129	BCL2 interacting killer	Homo sapiens	175-178
22565810-6	2012	Confirming these network data, we observed that cells with reduced levels of icb-1 exhibited an impaired response to the apoptosis inducers tamoxifen, staurosporine, actinomycin, and camptothecin.	Staurosporine	151-164	thymocyte selection associated family member 2	Homo sapiens	77-82
22674388-4	2012	We found that expression of Gal-3 increased when exposed to the apoptosis inducer staurosporine.	Staurosporine	82-95	galectin 3	Homo sapiens	28-33
22484386-0	2012	Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells.	Staurosporine	34-47	tumor protein p53	Homo sapiens	68-71
22707614-12	2012	p14(ARF)-hypermethylated IPF fibroblasts were significantly more resistant to staurosporine-and S-nitrosoglutathione-induced apoptosis compared with normal and nonmethylated IPF fibroblasts (P &lt; 0.01) and showed reduced levels of p53.	Staurosporine	78-91	ribonuclease P/MRP subunit p14	Homo sapiens	0-3
22484386-0	2012	Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells.	Staurosporine	34-47	BCL2 apoptosis regulator	Homo sapiens	109-114
22784310-3	2012	Ang II induced increased expression of Gialpha proteins in A10 VSMC was markedly attenuated by actinomycin D, losartan (an AT(1) receptor antagonist), dibutyryl cAMP, phospholipase C (PLC) inhibitor U73122, protein kinase C (PKC) inhibitors staurosporine and GP109203X, but not by PD123319 (an AT(2) receptor antagonist).	Staurosporine	241-254	angiotensinogen	Homo sapiens	0-6
22460504-3	2012	Caspase-3 activation and DNA laddering induced by staurosporine were abolished by blockers of K(+) and Cl(-) channels or cytosolic Ca(2+) chelation.	Staurosporine	50-63	caspase 3	Homo sapiens	0-9
22460504-4	2012	Staurosporine induced decreases in the intracellular free K(+) and Cl(-) concentrations ([K(+)](i) and [Cl(-)](i)) in an early stage prior to caspase-3 activation.	Staurosporine	0-13	caspase 3	Homo sapiens	142-151
22415835-7	2012	(iii) Protein kinase C inhibitors, staurosporine and rottlerin, could decrease the percentage of F1BGFP(+) cells and their neurosphere formation efficiency through reducing the RFX2/3 complex.	Staurosporine	35-48	regulatory factor X2	Homo sapiens	177-181
22473799-2	2012	One of them, the type 1 inositol-1,4,5-trisphosphate receptor (IP(3) R-1), a multimeric receptor located on the endoplasmic reticulum (ER) membrane that is critical to calcium homeostasis, was reported to be cleaved during staurosporine (STS) induced-apoptosis in Jurkat cells.	Staurosporine	223-236	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	17-72
22473799-2	2012	One of them, the type 1 inositol-1,4,5-trisphosphate receptor (IP(3) R-1), a multimeric receptor located on the endoplasmic reticulum (ER) membrane that is critical to calcium homeostasis, was reported to be cleaved during staurosporine (STS) induced-apoptosis in Jurkat cells.	Staurosporine	238-241	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	17-72
22712885-9	2012	A soluble peptide corresponding to R46-cleaved PAR1 enhanced the endothelial barrier function and reduced staurosporine toxicity in endothelial as well as in 293T cells if PAR1 was expressed.	Staurosporine	106-119	coagulation factor II thrombin receptor	Homo sapiens	47-51
22647294-5	2012	Intracerebroventricular infusion of the protein kinase inhibitor staurosporine at 25 ng/day, to inhibit SIK1 further increased mean arterial pressure (MAP) and HR but did not affect the increase in CSF [Na(+)] or hypothalamic aldosterone in Dahl S on a high-salt diet.	Staurosporine	65-78	salt-inducible kinase 1	Rattus norvegicus	104-108
22702503-0	2012	CCR3 induced-p42/44 MAPK activation protects against staurosporine induced-DNA fragmentation but not apoptosis in airway smooth muscle cells.	Staurosporine	53-66	C-C motif chemokine receptor 3	Homo sapiens	0-4
22702503-0	2012	CCR3 induced-p42/44 MAPK activation protects against staurosporine induced-DNA fragmentation but not apoptosis in airway smooth muscle cells.	Staurosporine	53-66	cyclin dependent kinase 20	Homo sapiens	13-16
22589539-6	2012	Overexpression of Bcl-xL prevented staurosporine-induced apoptosis in cells expressing native VDAC1 but not certain VDAC1 mutants.	Staurosporine	35-48	BCL2 like 1	Homo sapiens	18-24
22589539-6	2012	Overexpression of Bcl-xL prevented staurosporine-induced apoptosis in cells expressing native VDAC1 but not certain VDAC1 mutants.	Staurosporine	35-48	voltage dependent anion channel 1	Homo sapiens	94-99
22589539-9	2012	Moreover, expression of the recombinant peptides in cells overexpressing Bcl-xL prevented protection offered by the protein against staurosporine-induced apoptosis.	Staurosporine	132-145	BCL2 like 1	Homo sapiens	73-79
22739984-0	2012	Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia.	Staurosporine	69-82	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-40
22634011-0	2012	Staurosporine induces ganglion cell differentiation in part by stimulating urokinase-type plasminogen activator expression and activation in the developing chick retina.	Staurosporine	0-13	plasminogen activator, urokinase	Gallus gallus	75-111
22634011-1	2012	Here, we investigated whether staurosporine-mediated urokinase-type plasminogen activator (uPA) activation is involved in retinal ganglion cell (RGC) differentiation.	Staurosporine	30-43	plasminogen activator, urokinase	Gallus gallus	53-89
22634011-1	2012	Here, we investigated whether staurosporine-mediated urokinase-type plasminogen activator (uPA) activation is involved in retinal ganglion cell (RGC) differentiation.	Staurosporine	30-43	plasminogen activator, urokinase	Gallus gallus	91-94
22634011-5	2012	Western blotting of cell lysates showed that staurosporine induced high levels of the active form of uPA.	Staurosporine	45-58	plasminogen activator, urokinase	Gallus gallus	101-104
22634011-6	2012	The staurosporine-induced uPA signal was localized predominantly in the soma, neurites and axons of Tuj-1-positive ganglion cells.	Staurosporine	4-17	plasminogen activator, urokinase	Gallus gallus	26-29
22634011-7	2012	Amiloride, an inhibitor of uPA, markedly reduced staurosporine-induced Tuj-1 staining, neurite length, neurite number, and uPA staining versus controls.	Staurosporine	49-62	plasminogen activator, urokinase	Gallus gallus	27-30
22634011-7	2012	Amiloride, an inhibitor of uPA, markedly reduced staurosporine-induced Tuj-1 staining, neurite length, neurite number, and uPA staining versus controls.	Staurosporine	49-62	plasminogen activator, urokinase	Gallus gallus	123-126
22634011-8	2012	In developing retinas in ovo, amiloride administration remarkably reduced the staurosporine-induced uPA staining and RGC differentiation.	Staurosporine	78-91	plasminogen activator, urokinase	Gallus gallus	100-103
22634011-9	2012	Taken together, our in vitro and in vivo data collectively indicate that uPA plays a role in the staurosporine-mediated stimulation of RGC differentiation.	Staurosporine	97-110	plasminogen activator, urokinase	Gallus gallus	73-76
22387294-7	2012	We found that staurosporine and GF109203X, inhibitors of PKC, and Y-27632 and HA 1077, Rho kinase inhibitors, reduced the ET-1-induced Delta[Ca(2+)](i) by &gt;70%.	Staurosporine	14-27	endothelin 1	Rattus norvegicus	122-126
22481440-9	2012	PCSK9 RNAi also reduced staurosporine-induced CGN apoptosis and axonal degeneration in the nerve growth factor-deprived dorsal root ganglion neurons.	Staurosporine	24-37	proprotein convertase subtilisin/kexin type 9	Homo sapiens	0-5
22465356-5	2012	Our digital holographic experiments showed that after exposure to 1 muM staurosporine for 4 h, the volumes of KB cells were reduced by ~50-60%, which is consistent with previous results obtained using electronic cell sizing and atomic force microscopy.	Staurosporine	72-85	latexin	Homo sapiens	68-71
22513473-7	2012	On the contrary, PKC inhibitor Staurosporine significantly decreased the response to gradient calcium ions and E(max) of SMA in Shock+Ligation and Shock+Drainage groups.	Staurosporine	31-44	protein kinase C, gamma	Rattus norvegicus	17-20
22352691-6	2012	Staurosporine also markedly attenuated the high glucose-induced downregulation of V(1A)  receptors on mesangial cells and blocked the depressed [Ca(2+) ](i)  response and increased ERK activity induced by AVP.	Staurosporine	0-13	Eph receptor B1	Rattus norvegicus	181-184
22389449-7	2012	Hypoxic cells containing VDAC1-DeltaC were less sensitive to staurosporine- and etoposide-induced cell death, and silencing of VDAC1-DeltaC or treatment with the tetracycline antibiotics restored sensitivity.	Staurosporine	61-74	voltage dependent anion channel 1	Homo sapiens	25-30
22322297-6	2012	Suppression of STAT3 signaling diminished resistance of IPF LFs to staurosporine-induced apoptosis and responsiveness to transforming growth factor beta(1) but increased basal alpha-SMA and restored beta(3) integrin expression in LFs via an ALK-5-dependent, SMAD3/7-independent mechanism.	Staurosporine	67-80	signal transducer and activator of transcription 3	Homo sapiens	15-20
22322297-6	2012	Suppression of STAT3 signaling diminished resistance of IPF LFs to staurosporine-induced apoptosis and responsiveness to transforming growth factor beta(1) but increased basal alpha-SMA and restored beta(3) integrin expression in LFs via an ALK-5-dependent, SMAD3/7-independent mechanism.	Staurosporine	67-80	transforming growth factor beta receptor 1	Homo sapiens	241-246
22322297-6	2012	Suppression of STAT3 signaling diminished resistance of IPF LFs to staurosporine-induced apoptosis and responsiveness to transforming growth factor beta(1) but increased basal alpha-SMA and restored beta(3) integrin expression in LFs via an ALK-5-dependent, SMAD3/7-independent mechanism.	Staurosporine	67-80	SMAD family member 3	Homo sapiens	258-263
21938721-5	2012	SH-SY5Y cells stably over-expressing AMIGO are more resistant to apoptosis induced by staurosporine and H(2) O(2) compared to vector controls.	Staurosporine	86-99	adhesion molecule with Ig like domain 1	Homo sapiens	37-42
22812230-9	2012	MMP1 expression was significantly further upregluted by pre-cubation with SP in hypoxia, however collagen type I, TIMP1 in supernatant fluid and pro-collalpha1, p-smad2 in cells were inhibited (P &lt; 0.05, vs. hypoxia group).	Staurosporine	74-76	matrix metallopeptidase 1	Homo sapiens	0-4
22238304-9	2012	Furthermore, deletion of ORF12 rendered VZV-infected cells more susceptible to staurosporine-induced apoptosis.	Staurosporine	79-92	tegument protein VP11/12	Human alphaherpesvirus 3	25-30
22199367-7	2012	Aortic SMCs from aged SOD2+/- mice showed increased collagen I and decreased elastin expression, increased matrix metalloproteinase-2 expression and activity, and increased sensitivity to staurosporine-induced apoptosis versus aged wild-type and young (4-month-old) SOD2+/- mice.	Staurosporine	188-201	superoxide dismutase 2, mitochondrial	Mus musculus	22-26
22199367-7	2012	Aortic SMCs from aged SOD2+/- mice showed increased collagen I and decreased elastin expression, increased matrix metalloproteinase-2 expression and activity, and increased sensitivity to staurosporine-induced apoptosis versus aged wild-type and young (4-month-old) SOD2+/- mice.	Staurosporine	188-201	superoxide dismutase 2, mitochondrial	Mus musculus	266-270
22199367-11	2012	Finally, dominant-negative Forkhead box O3a overexpression attenuated staurosporine-induced apoptosis in aged SOD2+/- SMCs.	Staurosporine	70-83	superoxide dismutase 2, mitochondrial	Mus musculus	110-114
21692986-0	2012	Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin beta1-actin complex in breast cancer cells.	Staurosporine	22-35	profilin 1	Homo sapiens	0-9
21692986-0	2012	Profilin1 facilitates staurosporine-triggered apoptosis by stabilizing the integrin beta1-actin complex in breast cancer cells.	Staurosporine	22-35	integrin subunit beta 1	Homo sapiens	75-89
21692986-4	2012	In this study, we found that stable expression of ectopic Pfn1 sensitized the breast cancer cell line MDA-MB-468 to apoptosis induced by staurosporine, a widely used natural apoptosis-inducing agent.	Staurosporine	137-150	profilin 1	Homo sapiens	58-62
21692986-6	2012	Furthermore, the Pfn1-facilitated apoptosis induced by staurosporine was blocked in cells attached to a supplementary fibronectin substrate, which serves as a ligand of integrin alpha5beta1.	Staurosporine	55-68	profilin 1	Homo sapiens	17-21
21692986-6	2012	Furthermore, the Pfn1-facilitated apoptosis induced by staurosporine was blocked in cells attached to a supplementary fibronectin substrate, which serves as a ligand of integrin alpha5beta1.	Staurosporine	55-68	fibronectin 1	Homo sapiens	118-129
21692986-9	2012	Our study indicated a previously uncharacterized role of Pfn1 in mediating staurosporine-inducing apoptosis in breast cancer cells via up-regulating integrin alpha5beta1, and suggested a new target for breast cancer therapy.	Staurosporine	75-88	profilin 1	Homo sapiens	57-61
22285488-0	2012	Scythe cleavage during Fas (APO-1)-and staurosporine-mediated apoptosis.	Staurosporine	39-52	BAG cochaperone 6	Homo sapiens	0-6
22285488-2	2012	Here we show that cleavage of Scythe by caspase-3 occurs after activation of both the extrinsic (i.e. Fas/APO-1-mediated) and the intrinsic (i.e. staurosporine-induced) apoptosis pathway.	Staurosporine	146-159	BAG cochaperone 6	Homo sapiens	30-36
22285488-2	2012	Here we show that cleavage of Scythe by caspase-3 occurs after activation of both the extrinsic (i.e. Fas/APO-1-mediated) and the intrinsic (i.e. staurosporine-induced) apoptosis pathway.	Staurosporine	146-159	caspase 3	Homo sapiens	40-49
22253444-9	2012	After staurosporine treatment, the preferential processing of ICAD in the cytosolic fraction allows the translocation of DFF40/CAD from this fraction to a chromatin-enriched one.	Staurosporine	6-19	DNA fragmentation factor subunit alpha	Homo sapiens	62-66
22253444-9	2012	After staurosporine treatment, the preferential processing of ICAD in the cytosolic fraction allows the translocation of DFF40/CAD from this fraction to a chromatin-enriched one.	Staurosporine	6-19	DNA fragmentation factor subunit beta	Homo sapiens	121-126
22253444-9	2012	After staurosporine treatment, the preferential processing of ICAD in the cytosolic fraction allows the translocation of DFF40/CAD from this fraction to a chromatin-enriched one.	Staurosporine	6-19	aconitate decarboxylase 1	Homo sapiens	63-66
22253444-10	2012	Therefore, the low levels of cytosolic DFF40/CAD detected in SK-N-AS cells determine the absence of DNA laddering after staurosporine treatment.	Staurosporine	120-133	DNA fragmentation factor subunit beta	Homo sapiens	39-44
22253444-10	2012	Therefore, the low levels of cytosolic DFF40/CAD detected in SK-N-AS cells determine the absence of DNA laddering after staurosporine treatment.	Staurosporine	120-133	aconitate decarboxylase 1	Homo sapiens	45-48
22253444-11	2012	In these cells DFF40/CAD cytosolic levels can be restored by the overexpression of their own endonuclease, which is sufficient to make them proficient at degrading their chromatin into oligonucleosome-size fragments after staurosporine treatment.	Staurosporine	222-235	DNA fragmentation factor subunit beta	Homo sapiens	15-20
22253444-11	2012	In these cells DFF40/CAD cytosolic levels can be restored by the overexpression of their own endonuclease, which is sufficient to make them proficient at degrading their chromatin into oligonucleosome-size fragments after staurosporine treatment.	Staurosporine	222-235	aconitate decarboxylase 1	Homo sapiens	21-24
22198335-9	2012	The staurosporine (PKC inhibitor), both SB386023 and U0126 (extracellular signal related kinases 1 and 2 inhibitor), and wedelolactone (NF-kappaB inhibitor) almost totally abolished organ culture-increased and mmLDL-increased contraction and expressions of endothelin ET(B) receptor.	Staurosporine	4-17	endothelin receptor type B	Rattus norvegicus	268-273
22159547-6	2012	Dose-response profiles of caspase-3 activity as a function of staurosporine concentration were generated using both the digital microfluidic method and conventional techniques (i.e., pipetting, aspiration, and 96-well plates.)	Staurosporine	62-75	caspase 3	Homo sapiens	26-35
22184125-4	2012	We first show that both recombinant sAPPalpha and N1, but not its inactive parent fragment N2, reduce staurosporine-stimulated caspase-3 activation and TUNEL-positive cell death by lowering p53 promoter transactivation and activity in human cells.	Staurosporine	102-115	caspase 3	Homo sapiens	127-136
22184125-4	2012	We first show that both recombinant sAPPalpha and N1, but not its inactive parent fragment N2, reduce staurosporine-stimulated caspase-3 activation and TUNEL-positive cell death by lowering p53 promoter transactivation and activity in human cells.	Staurosporine	102-115	tumor protein p53	Homo sapiens	190-193
22173127-9	2012	Furthermore, in pretreatment of oocytes with chelerythrine or staurosporine, two PKC inhibitors, EAAT3 activity was significantly decreased.	Staurosporine	62-75	solute carrier family 1 member 1	Rattus norvegicus	97-102
22262180-9	2012	Ectopic expression of GFP-fused BCL2L12 or BCL2L12A in U87MG cells leads to repression of apoptotic markers and protects against staurosporine (STS) insults, indicating an antiapoptotic role for both BCL2L12 and BCL2L12A.	Staurosporine	129-142	BCL2 like 12	Homo sapiens	32-39
22262180-9	2012	Ectopic expression of GFP-fused BCL2L12 or BCL2L12A in U87MG cells leads to repression of apoptotic markers and protects against staurosporine (STS) insults, indicating an antiapoptotic role for both BCL2L12 and BCL2L12A.	Staurosporine	129-142	BCL2 like 12	Homo sapiens	43-50
22262180-9	2012	Ectopic expression of GFP-fused BCL2L12 or BCL2L12A in U87MG cells leads to repression of apoptotic markers and protects against staurosporine (STS) insults, indicating an antiapoptotic role for both BCL2L12 and BCL2L12A.	Staurosporine	129-142	BCL2 like 12	Homo sapiens	43-50
22401168-0	2012	gamma-Secretase-dependent cleavage of E-cadherin by staurosporine in breast cancer cells.	Staurosporine	52-65	cadherin 1	Homo sapiens	38-48
23047106-5	2012	DNA laddering and annexin V/PI staining assays further indicated that although tetracycline-inducible expression of survivin conferred resistance to NH4Cl- and staurosporine-induced apoptosis in both the B2- and the B5-derived stable cell lines, the B2-derived cell lines showed more stringent regulation in the absence of tetracycline.	Staurosporine	160-173	survivin	Cricetulus griseus	116-124
22401168-3	2012	In this study, we report that staurosporine (STS)-induced apoptosis induces caspase-2 and/or -8-dependent E-cadherin cleavage.	Staurosporine	30-43	caspase 2	Homo sapiens	76-116
22401168-3	2012	In this study, we report that staurosporine (STS)-induced apoptosis induces caspase-2 and/or -8-dependent E-cadherin cleavage.	Staurosporine	45-48	caspase 2	Homo sapiens	76-116
22208917-8	2012	Staurosporine, a universal kinase inhibitor, inhibited Src activity in an ATP concentration-dependent manner.	Staurosporine	0-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	55-58
22155294-6	2012	The three-dimensional structures of the active, triphosphorylated and the unphosphorylated, inactive kinase domain of CTR1 in complex with staurosporine illustrate the conformational rearrangements that form the basis of activity regulation.	Staurosporine	139-152	Protein kinase superfamily protein	Arabidopsis thaliana	118-122
22649731-7	2012	Phosphoprotein analysis (Pro-Q Diamond stain) confirmed that staurosporine significantly blunted the frequency-dependent phosphorylation at Troponin I and Myosin light chain-2.	Staurosporine	61-74	myosin regulatory light chain 2, ventricular/cardiac muscle isoform	Oryctolagus cuniculus	155-175
22185759-7	2012	Moreover, MAL/MRTF-dependent transcriptional activity and target gene expression is upregulated upon stimulation of fibroblasts with TNF and staurosporin.	Staurosporine	141-153	mal, T cell differentiation protein	Homo sapiens	10-13
21842421-9	2012	The capacity of regucalcin to augment RANKL-induced NF-kappaB activity was inhibited by menaquinone-7, a potent NF-kappaB antagonist, while the Erk inhibitor PD98059 and staurosporine had no effect, demonstrating a specific effect on NF-kappaB signaling.	Staurosporine	170-183	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	38-43
22109884-8	2012	Conversely, the nonselective SIK inhibitor, staurosporine, increased nuclear TORC2 content and stimulated CRH transcription in 4Bcells and primary neuronal cultures (heteronuclear RNA).	Staurosporine	44-57	salt-inducible kinase 1	Rattus norvegicus	29-32
22109884-8	2012	Conversely, the nonselective SIK inhibitor, staurosporine, increased nuclear TORC2 content and stimulated CRH transcription in 4Bcells and primary neuronal cultures (heteronuclear RNA).	Staurosporine	44-57	CREB regulated transcription coactivator 2	Rattus norvegicus	77-82
22109884-8	2012	Conversely, the nonselective SIK inhibitor, staurosporine, increased nuclear TORC2 content and stimulated CRH transcription in 4Bcells and primary neuronal cultures (heteronuclear RNA).	Staurosporine	44-57	corticotropin releasing hormone	Rattus norvegicus	106-109
21880693-4	2012	Dasatinib, sorafenib, PD173074 and staurosporine showed similar inhibition against different phosphorylation states of CSF-1R, but pazopanib, sunitinib, GW2580 and imatinib showed more potent inhibition against dephosphorylated CSF-1R.	Staurosporine	35-48	colony stimulating factor 1 receptor	Homo sapiens	119-125
21880693-4	2012	Dasatinib, sorafenib, PD173074 and staurosporine showed similar inhibition against different phosphorylation states of CSF-1R, but pazopanib, sunitinib, GW2580 and imatinib showed more potent inhibition against dephosphorylated CSF-1R.	Staurosporine	35-48	colony stimulating factor 1 receptor	Homo sapiens	228-234
21880693-5	2012	Binding analysis of the inhibitors to the two different phosphorylation forms of CSF-1R, using surface plasmon resonance spectrometry, revealed that staurosporine bound to both forms with similar affinity, but sunitinib bound to the dephosphorylated form with higher affinity.	Staurosporine	149-162	colony stimulating factor 1 receptor	Homo sapiens	81-87
22261541-4	2012	Thus, C1 potentiates staurosporine (STS)-induced caspase-3 activation by upregulating p53 transcription, mRNA levels and activity.	Staurosporine	21-34	caspase 3	Rattus norvegicus	49-58
21945539-9	2012	Importantly, the protection afforded by IGF-1 against staurosporine-induced metabolic dysfunction and apoptosis is abrogated in PINK1-deficient cells.	Staurosporine	54-67	insulin-like growth factor 1	Mus musculus	40-45
22261541-4	2012	Thus, C1 potentiates staurosporine (STS)-induced caspase-3 activation by upregulating p53 transcription, mRNA levels and activity.	Staurosporine	21-34	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	86-89
22261541-4	2012	Thus, C1 potentiates staurosporine (STS)-induced caspase-3 activation by upregulating p53 transcription, mRNA levels and activity.	Staurosporine	36-39	caspase 3	Rattus norvegicus	49-58
22261541-4	2012	Thus, C1 potentiates staurosporine (STS)-induced caspase-3 activation by upregulating p53 transcription, mRNA levels and activity.	Staurosporine	36-39	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	86-89
23133614-5	2012	Compared to control cells, PrP knockdown cells exhibited an increased susceptibility to serum deprivation induced apoptosis, no change to staurosporine- or paclitaxel-induced cell deaths, and a reduced susceptibility to chemotherapy drug doxorubicin-induced cell death.	Staurosporine	138-151	prion protein	Homo sapiens	27-30
22860037-8	2012	Moreover both the staurosporine-triggered and the classical death ligand-induced necroptotic pathway can be effectively arrested by a lysosomal enzyme inhibitor CA-074-OMe and the recently discovered MLKL inhibitor necrosulfonamide.	Staurosporine	18-31	mixed lineage kinase domain like pseudokinase	Homo sapiens	200-204
23139834-7	2012	The increase in activity was specifically inhibited in the presence of Staurosporine, a protein kinase inhibitor, suggesting that the Cah3 protein was post-translationally regulated via phosphorylation.	Staurosporine	71-84	uncharacterized protein	Chlamydomonas reinhardtii	134-138
22848756-7	2012	Quantitative flow cytometry revealed that in 143B TK(-) cells treated with staurosporine, cyt c and Smac exit mitochondria asymmetrically, with cyt c redistribution preceding that of Smac.	Staurosporine	75-88	cytochrome c, somatic	Homo sapiens	90-95
22848756-7	2012	Quantitative flow cytometry revealed that in 143B TK(-) cells treated with staurosporine, cyt c and Smac exit mitochondria asymmetrically, with cyt c redistribution preceding that of Smac.	Staurosporine	75-88	diablo IAP-binding mitochondrial protein	Homo sapiens	100-104
22848756-7	2012	Quantitative flow cytometry revealed that in 143B TK(-) cells treated with staurosporine, cyt c and Smac exit mitochondria asymmetrically, with cyt c redistribution preceding that of Smac.	Staurosporine	75-88	cytochrome c, somatic	Homo sapiens	144-149
22848756-7	2012	Quantitative flow cytometry revealed that in 143B TK(-) cells treated with staurosporine, cyt c and Smac exit mitochondria asymmetrically, with cyt c redistribution preceding that of Smac.	Staurosporine	75-88	diablo IAP-binding mitochondrial protein	Homo sapiens	183-187
22160868-4	2012	The engineered B cells expressing Bcl-x(L) exhibited progressively lower increases in apoptosis activation as measured by caspase-3 activity after successive rounds of selective pressure with staurosporine treatment.	Staurosporine	192-205	BCL2 like 1	Homo sapiens	34-42
22100646-7	2011	Whilst there was no evidence of increased cell death under basal condition, we observed a significant increase in apoptotic nuclei following Staurosporine treatment in CLN1 cells only.	Staurosporine	141-154	palmitoyl-protein thioesterase 1	Homo sapiens	168-172
22375159-6	2012	In live liver cell (AML 12) experiments, the optical probe for caspase-3 activity emitted signals in response to Fas-ligand, staurosporine and hypoxia/reoxygenation, demonstrating that the probe can measure cellular apoptosis quantitatively.	Staurosporine	125-138	caspase 3	Mus musculus	63-72
22349387-5	2012	The purpose of the present study is to determine the effects of extracellular signal-regulated kinases (ERKs) phosphorylation on the apoptosis of HSCs induced by staurosporine.	Staurosporine	162-175	mitogen activated protein kinase 3	Rattus norvegicus	104-108
22349387-10	2012	Staurosporine further increased ERK1/2 phosphorylation in both cell lines.	Staurosporine	0-13	mitogen activated protein kinase 3	Rattus norvegicus	32-38
22349387-11	2012	CONCLUSION: ERK1/2 phosphorylation in HSCs determines the sensitivity of HSCs to staurosporine-induced apoptosis.	Staurosporine	81-94	mitogen activated protein kinase 3	Rattus norvegicus	12-18
21843636-5	2011	While PPARbeta/delta-dependent attenuation of staurosporine- or UVB-induced poly (ADP-ribose) polymerase (PARP) cleavage was not observed, PPARbeta/delta- and PPARgamma-dependent repression of UVB-induced expression and secretion of inflammatory cytokines was found in HaCaT keratinocytes over-expressing PPARbeta/delta or PPARgamma.	Staurosporine	46-59	peroxisome proliferator activated receptor delta	Homo sapiens	6-14
21843636-5	2011	While PPARbeta/delta-dependent attenuation of staurosporine- or UVB-induced poly (ADP-ribose) polymerase (PARP) cleavage was not observed, PPARbeta/delta- and PPARgamma-dependent repression of UVB-induced expression and secretion of inflammatory cytokines was found in HaCaT keratinocytes over-expressing PPARbeta/delta or PPARgamma.	Staurosporine	46-59	poly(ADP-ribose) polymerase 1	Homo sapiens	106-110
22101277-5	2011	In normal fibroblasts, overexpression of C1qbp protected the cells against staurosporine-induce apoptosis, increased proliferation, decreased cellular ATP, and increased cell migration in a wound-healing assay.	Staurosporine	75-88	complement C1q binding protein	Homo sapiens	41-46
22098422-7	2011	However, corticohippocampal neurons lacking RhoB exhibited a reduction in the degree of DNA fragmentation and caspase 3 activation induced by the apoptotic agent staurosporine, in parallel with increased neuronal survival.	Staurosporine	162-175	ras homolog family member B	Mus musculus	44-48
21988553-6	2011	Also, the activation of ERK1/2 and ROCK-I was examined by Western blot assay after treatment with or without Ap(4)A, U73122, Staurosporine, Bisindolylmaleimide-I and PDBU.	Staurosporine	125-138	rho-associated protein kinase 1	Oryctolagus cuniculus	35-41
22098422-7	2011	However, corticohippocampal neurons lacking RhoB exhibited a reduction in the degree of DNA fragmentation and caspase 3 activation induced by the apoptotic agent staurosporine, in parallel with increased neuronal survival.	Staurosporine	162-175	caspase 3	Mus musculus	110-119
22098422-8	2011	Staurosporine induction of caspase 9 activity was also suppressed.	Staurosporine	0-13	caspase 9	Mus musculus	27-36
21917911-9	2011	Of importance, pharmacological inhibition or silencing of the NAD-dependent enzyme SIRT1 abrogated the ability of eNAD to provide protection from staurosporine, having no effect on eNAD-dependent protection from C2-ceramide or N-methyl-N"-nitro-N-nitrosoguanidine.	Staurosporine	146-159	sirtuin 1	Homo sapiens	83-88
21930174-1	2011	We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS).	Staurosporine	200-213	nerve growth factor	Rattus norvegicus	30-49
21930174-1	2011	We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS).	Staurosporine	200-213	nerve growth factor	Rattus norvegicus	51-54
21930174-1	2011	We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS).	Staurosporine	215-218	nerve growth factor	Rattus norvegicus	30-49
21930174-1	2011	We have shown previously that nerve growth factor (NGF) requires only low nanomolar ATP concentrations in the cell culture medium to protect cortical rat neurons (CRN) from cellular damage induced by staurosporine (STS).	Staurosporine	215-218	nerve growth factor	Rattus norvegicus	51-54
21679777-7	2011	Furthermore, overexpression of wild type Hsp27 in mutant MERRF cybrids significantly decreased cell death under staurosporine (STS) treatment, suggesting a protective function of Hsp27 in cells harboring the A8344G mutation of mtDNA.	Staurosporine	112-125	heat shock protein family B (small) member 1	Homo sapiens	41-46
21437645-3	2011	Although caspase-9 activation and cleavage of procaspase-3 were significant following staurosporine treatment, neither was observed following H(2)O(2) treatment, indicating a non-apoptotic death.	Staurosporine	86-99	caspase 9	Homo sapiens	9-18
21437645-3	2011	Although caspase-9 activation and cleavage of procaspase-3 were significant following staurosporine treatment, neither was observed following H(2)O(2) treatment, indicating a non-apoptotic death.	Staurosporine	86-99	caspase 3	Homo sapiens	46-58
22040290-4	2011	We observed that over-expression of MMP28 provided protection against apoptosis induced by either serum-deprivation or treatment with a protein kinase inhibitor, staurosporine.	Staurosporine	162-175	matrix metallopeptidase 28 (epilysin)	Mus musculus	36-41
21872252-5	2011	Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling (TUNEL) staining and caspase-3 activity assays determined that treatment of apoE(-/-) mice arteries with staurosporine (STS) significantly induced endothelial apoptosis associated with a reduction of CREG expression.	Staurosporine	182-195	apolipoprotein E	Mus musculus	153-157
21735095-6	2011	We show in particular that persistence of high CK2 level in R-CEM, as opposed to S-CEM, is accompanied by the presence of an immunospecific form of Cdc37 not detectable in S-CEM and refractory to staurosporine-induced degradation.	Staurosporine	196-209	cell division cycle 37, HSP90 cochaperone	Homo sapiens	148-153
21816831-5	2011	VWF secretion induced by Stx1B is associated with a transient rise in intracellular Ca(2+) level that is blocked by chelation with 1,2-bis(2-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid-acetoxymethyl ester, removal of extracellular Ca(2+), the phospholipase C inhibitor U73122, the protein kinase inhibitor staurosporine, or small interfering RNA knockdown of protein kinase Calpha.	Staurosporine	309-322	syntaxin 1B	Homo sapiens	25-30
21331591-0	2011	Staurosporine induces megakaryocytic differentiation through the upregulation of JAK/Stat3 signaling pathway.	Staurosporine	0-13	signal transducer and activator of transcription 3	Homo sapiens	85-90
21659556-0	2011	Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.	Staurosporine	74-87	caspase 9	Gallus gallus	103-112
21659556-0	2011	Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1.	Staurosporine	74-87	apoptotic peptidase activating factor 1	Gallus gallus	131-137
21659556-3	2011	Unlike conventional anticancer drugs, staurosporine and UCN-01 induced apoptosis in a variety of tumor cells overexpressing the apoptosis inhibitors Bcl-2 and Bcl-x(L).	Staurosporine	38-51	BCL2, apoptosis regulator	Gallus gallus	149-154
21659556-3	2011	Unlike conventional anticancer drugs, staurosporine and UCN-01 induced apoptosis in a variety of tumor cells overexpressing the apoptosis inhibitors Bcl-2 and Bcl-x(L).	Staurosporine	38-51	BCL2 like 1	Gallus gallus	159-167
21659556-5	2011	Nevertheless, as demonstrated in caspase-9-deficient murine embryonic fibroblasts, human lymphoma cells, and chicken DT40 cells, staurosporine-induced apoptosis was essentially mediated by caspase-9.	Staurosporine	129-142	caspase 9	Mus musculus	33-42
21659556-5	2011	Nevertheless, as demonstrated in caspase-9-deficient murine embryonic fibroblasts, human lymphoma cells, and chicken DT40 cells, staurosporine-induced apoptosis was essentially mediated by caspase-9.	Staurosporine	129-142	caspase 9	Gallus gallus	189-198
21659556-6	2011	Our results therefore suggest that, in addition to the classical cytochrome c/Apaf-1-dependent pathway of caspase-9 activation, staurosporine can induce caspase-9 activation and apoptosis independently of the apoptosome.	Staurosporine	128-141	cytochrome c, somatic	Gallus gallus	65-77
21659556-6	2011	Our results therefore suggest that, in addition to the classical cytochrome c/Apaf-1-dependent pathway of caspase-9 activation, staurosporine can induce caspase-9 activation and apoptosis independently of the apoptosome.	Staurosporine	128-141	caspase 9	Gallus gallus	153-162
21683152-0	2011	Reactive oxygen species participate in the p38-mediated apoptosis induced by potassium deprivation and staurosporine in cerebellar granule neurons.	Staurosporine	103-116	mitogen-activated protein kinase 14	Homo sapiens	43-46
21683152-4	2011	No information is available about the role of other signaling pathways such as p38 in staurosporine-induced apoptosis, and whether p38 activation could be related to ROS levels induced by both K5 and staurosporine.	Staurosporine	200-213	mitogen-activated protein kinase 14	Homo sapiens	131-134
21683152-7	2011	On the other hand, staurosporine promotes a sustained activation of p38.	Staurosporine	19-32	mitogen-activated protein kinase 14	Homo sapiens	68-71
21683152-8	2011	We found that p38 inhibition markedly decreases ROS generation, NOX activity and apoptosis induced by staurosporine.	Staurosporine	102-115	mitogen-activated protein kinase 14	Homo sapiens	14-17
21683152-9	2011	Furthermore, antioxidants inhibit p38 activation induced by staurosporine.	Staurosporine	60-73	mitogen-activated protein kinase 14	Homo sapiens	34-37
21683152-10	2011	These data indicate that apoptosis induced by both K5 and staurosporine is dependent on p38 activation, which is mediated by ROS.	Staurosporine	58-71	mitogen-activated protein kinase 14	Homo sapiens	88-91
21683152-11	2011	In addition, p38 activation by staurosporine induces a further production of ROS through NOX activation.	Staurosporine	31-44	mitogen-activated protein kinase 14	Homo sapiens	13-16
21778271-9	2011	The authors also show that SOCS1 protected retinal cells from staurosporine as well as H2O2-induced apoptosis.	Staurosporine	62-75	suppressor of cytokine signaling 1	Homo sapiens	27-32
21857110-0	2011	Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death.	Staurosporine	81-94	ret proto-oncogene	Homo sapiens	60-63
21857110-0	2011	Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death.	Staurosporine	81-94	patched 1	Homo sapiens	64-68
21857110-3	2011	The bacterial alkaloid staurosporine and the plant extract rotenone are death-inducing drugs that have an inhibitory synergistic effect on the growth of TPC-1 cells.	Staurosporine	23-36	two pore segment channel 1	Homo sapiens	153-158
21679777-7	2011	Furthermore, overexpression of wild type Hsp27 in mutant MERRF cybrids significantly decreased cell death under staurosporine (STS) treatment, suggesting a protective function of Hsp27 in cells harboring the A8344G mutation of mtDNA.	Staurosporine	127-130	heat shock protein family B (small) member 1	Homo sapiens	41-46
21593448-4	2011	Cell death was induced by H(2)O(2) (1,000 muM) or staurosporine (StSp, 5 muM), and it was shown that cold shock and RBM3 transfection were associated with attenuation of morphological changes and an increase in cell viability compared with normal temperature or empty vector, respectively.	Staurosporine	50-63	steroid sulfatase	Homo sapiens	65-69
21823219-11	2011	Annexin-V-binding was blunted by Ca(2+) removal, by the cation channel inhibitor amiloride (1 mM), by the protein kinase C inhibitor staurosporine (500 nM) but not by the pancaspase inhibitor zVAD (10 muM).	Staurosporine	133-146	annexin A5	Homo sapiens	0-9
21624466-7	2011	In a 6h short term culture, IL-4 reduced the death of microglial cells induced by staurosporine.	Staurosporine	82-95	interleukin 4	Mus musculus	28-32
21593448-4	2011	Cell death was induced by H(2)O(2) (1,000 muM) or staurosporine (StSp, 5 muM), and it was shown that cold shock and RBM3 transfection were associated with attenuation of morphological changes and an increase in cell viability compared with normal temperature or empty vector, respectively.	Staurosporine	50-63	RNA binding motif protein 3	Homo sapiens	116-120
21615407-0	2011	Phosphorylation of Ser45 and Ser59 of alphaB-crystallin and p38/extracellular regulated kinase activity determine alphaB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.	Staurosporine	198-211	crystallin, alpha B	Rattus norvegicus	38-55
21630016-4	2011	In addition, the levels of anti-apoptotic protein Bcl-2 (B-cell lymphoma protein-2) were restored by PD98059 or SB239063 in cells treated with H(2)O(2) or staurosporine, respectively.	Staurosporine	155-168	BCL2 apoptosis regulator	Homo sapiens	50-55
21630016-4	2011	In addition, the levels of anti-apoptotic protein Bcl-2 (B-cell lymphoma protein-2) were restored by PD98059 or SB239063 in cells treated with H(2)O(2) or staurosporine, respectively.	Staurosporine	155-168	BCL2 apoptosis regulator	Homo sapiens	57-82
21630016-5	2011	We also found that inhibition of the nuclear import of p-Erk and p-p38 using wheat germ agglutinin induced apoptosis resistance in young HDF cells in response to H(2)O(2) or staurosporine.	Staurosporine	174-187	mitogen-activated protein kinase 1	Homo sapiens	57-60
21630016-5	2011	We also found that inhibition of the nuclear import of p-Erk and p-p38 using wheat germ agglutinin induced apoptosis resistance in young HDF cells in response to H(2)O(2) or staurosporine.	Staurosporine	174-187	mitogen-activated protein kinase 1	Homo sapiens	67-70
21630016-7	2011	Moreover, the nuclear translocation of activated ERK1/2 and p38 in response to H(2)O(2) or staurosporine was significantly compromised in senescent HDFs, compared with young cells.	Staurosporine	91-104	mitogen-activated protein kinase 3	Homo sapiens	49-55
21630016-7	2011	Moreover, the nuclear translocation of activated ERK1/2 and p38 in response to H(2)O(2) or staurosporine was significantly compromised in senescent HDFs, compared with young cells.	Staurosporine	91-104	mitogen-activated protein kinase 1	Homo sapiens	60-63
21615407-0	2011	Phosphorylation of Ser45 and Ser59 of alphaB-crystallin and p38/extracellular regulated kinase activity determine alphaB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.	Staurosporine	198-211	Eph receptor B1	Rattus norvegicus	64-94
21615407-0	2011	Phosphorylation of Ser45 and Ser59 of alphaB-crystallin and p38/extracellular regulated kinase activity determine alphaB-crystallin-mediated protection of rat brain astrocytes from C2-ceramide- and staurosporine-induced cell death.	Staurosporine	198-211	crystallin, alpha B	Rattus norvegicus	114-131
21615407-1	2011	We previously demonstrated that alphaB-crystallin and protease-activated receptor (PAR) are involved in protection of astrocytes against C2-ceramide- and staurosporine-induced cell death [Li et al.	Staurosporine	154-167	crystallin, alpha B	Rattus norvegicus	32-49
21615407-1	2011	We previously demonstrated that alphaB-crystallin and protease-activated receptor (PAR) are involved in protection of astrocytes against C2-ceramide- and staurosporine-induced cell death [Li et al.	Staurosporine	154-167	plasminogen activator, urokinase receptor	Rattus norvegicus	54-81
21615407-1	2011	We previously demonstrated that alphaB-crystallin and protease-activated receptor (PAR) are involved in protection of astrocytes against C2-ceramide- and staurosporine-induced cell death [Li et al.	Staurosporine	154-167	plasminogen activator, urokinase receptor	Rattus norvegicus	83-86
21615407-4	2011	Our current data revealed that after down-regulation of alphaB-crystallin by siRNA, cell death caused by C2-ceramide and staurosporine is increased.	Staurosporine	121-134	crystallin, alpha B	Rattus norvegicus	56-73
21777855-8	2011	When the plants were treated with a kinase inhibitor Staurosporine, the MF depolymerization rate in pks5-4 was similar as that in wild-type under pH 8.3 treatment and the sensitivity of root growth was also rescued.	Staurosporine	53-66	SOS3-interacting protein 4	Arabidopsis thaliana	100-104
21385611-10	2011	Bacterially expressed Hck is capable of autophosphorylation, phosphorylates substrate at rates comparable to insect cell expressed Hck, and can be inhibited by staurosporine and Csk.	Staurosporine	160-173	HCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	22-25
21605370-7	2011	Interestingly, after staurosporine treatment caspase-6 activation was significantly delayed in neurites compared to cell bodies.	Staurosporine	21-34	caspase 6	Homo sapiens	45-54
21498608-9	2011	RESULTS: Staurosporine induced uPA and tPA levels in RGC-5 cells, and MMP-9, uPA, and tPA levels in the retinas and promoted the death of RGC-5 cells in vitro and RGCs and amacrine cells in vivo.	Staurosporine	9-22	plasminogen activator, urokinase	Mus musculus	31-34
21498608-9	2011	RESULTS: Staurosporine induced uPA and tPA levels in RGC-5 cells, and MMP-9, uPA, and tPA levels in the retinas and promoted the death of RGC-5 cells in vitro and RGCs and amacrine cells in vivo.	Staurosporine	9-22	plasminogen activator, tissue	Mus musculus	39-42
21145827-13	2011	We show that LIP promotes survival in staurosporine- or taxol-induced Hep3B cell death.	Staurosporine	38-51	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	13-16
21347840-6	2011	Results show that the classical apoptotic inducer, staurosporine, caused high elevations of cytosolic Ca(2+) that precede Bax translocation.	Staurosporine	51-64	BCL2 associated X, apoptosis regulator	Rattus norvegicus	122-125
21458410-9	2011	The abolition of the rapid effects through addition of Rp-cAMPS and staurosporine suggests that non genomic effects of 1,25(OH)(2)D(3) on NCX activity are mediated by activation of PKA and PKC pathways.	Staurosporine	68-81	T cell leukemia homeobox 2	Homo sapiens	138-141
21068357-0	2011	Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B.	Staurosporine	44-57	cathepsin B	Homo sapiens	111-122
21068357-4	2011	Finally, we show that cathepsin B is released in the cytosol of rho(0) cells in response to staurosporine, suggesting that the absence of mitochondrial activity leads to a facilitated permeabilization of lysosomal membranes in response to staurosporine.	Staurosporine	92-105	cathepsin B	Homo sapiens	22-33
21068357-4	2011	Finally, we show that cathepsin B is released in the cytosol of rho(0) cells in response to staurosporine, suggesting that the absence of mitochondrial activity leads to a facilitated permeabilization of lysosomal membranes in response to staurosporine.	Staurosporine	239-252	cathepsin B	Homo sapiens	22-33
21360572-0	2011	Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3beta/Tyr216, resulting in glycogen synthase kinase 3beta activation in SH-SY5Y human neuroblastoma cell lines.	Staurosporine	21-34	glycogen synthase kinase 3 beta	Homo sapiens	81-111
21360572-0	2011	Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3beta/Tyr216, resulting in glycogen synthase kinase 3beta activation in SH-SY5Y human neuroblastoma cell lines.	Staurosporine	21-34	glycogen synthase kinase 3 beta	Homo sapiens	133-163
21237154-1	2011	We report here the cleavage of the c-Jun N-terminal Kinase (JNK) pathway scaffold protein, JNK Interacting Protein-1 (JIP1), by caspases during both Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and staurosporine-induced apoptosis in HeLa cells.	Staurosporine	218-231	mitogen-activated protein kinase 8	Homo sapiens	35-58
21383007-7	2011	Furthermore, reduction of Bit-1 promoted both staurosporine and serum-deprivation induced apoptosis.	Staurosporine	46-59	peptidyl-tRNA hydrolase 2	Homo sapiens	26-31
21420381-4	2011	We analyzed expression levels and organization of plectin and other cytoskeletal elements, including intermediate filaments, microfilaments, and microtubules, after staurosporine-induced apoptosis in human Chang liver cells.	Staurosporine	165-178	plectin	Homo sapiens	50-57
21420381-7	2011	In vitro analysis indicated that plectin and cytokeratin 18 were cleaved following staurosporine-treatment of human Chang liver cells.	Staurosporine	83-96	plectin	Homo sapiens	33-40
21420381-7	2011	In vitro analysis indicated that plectin and cytokeratin 18 were cleaved following staurosporine-treatment of human Chang liver cells.	Staurosporine	83-96	keratin 18	Homo sapiens	45-59
21420381-9	2011	The organization of plectin and cytokeratin 18 networks collapsed after staurosporine-treatment.	Staurosporine	72-85	plectin	Homo sapiens	20-27
21420381-9	2011	The organization of plectin and cytokeratin 18 networks collapsed after staurosporine-treatment.	Staurosporine	72-85	keratin 18	Homo sapiens	32-46
21420381-10	2011	Conclusively, degradation of plectin induced by staurosporine-treatment in liver cells resulted in cytoskeleton disruption and induced morphological changes in these cells by affecting the expression and organization of cytokeratin 18.	Staurosporine	48-61	plectin	Homo sapiens	29-36
21420381-10	2011	Conclusively, degradation of plectin induced by staurosporine-treatment in liver cells resulted in cytoskeleton disruption and induced morphological changes in these cells by affecting the expression and organization of cytokeratin 18.	Staurosporine	48-61	keratin 18	Homo sapiens	220-234
21237154-5	2011	These data suggest that TRAIL and staurosporine induce JNK activation in a caspase-3-independent manner and that caspase-3-mediated JIP1 cleavage plays a role in JNK inactivation via scaffold disassembly during the execution phase of apoptosis.	Staurosporine	34-47	mitogen-activated protein kinase 8	Homo sapiens	55-58
21237154-5	2011	These data suggest that TRAIL and staurosporine induce JNK activation in a caspase-3-independent manner and that caspase-3-mediated JIP1 cleavage plays a role in JNK inactivation via scaffold disassembly during the execution phase of apoptosis.	Staurosporine	34-47	caspase 3	Homo sapiens	75-84
21237154-1	2011	We report here the cleavage of the c-Jun N-terminal Kinase (JNK) pathway scaffold protein, JNK Interacting Protein-1 (JIP1), by caspases during both Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and staurosporine-induced apoptosis in HeLa cells.	Staurosporine	218-231	mitogen-activated protein kinase 8	Homo sapiens	60-63
21237154-1	2011	We report here the cleavage of the c-Jun N-terminal Kinase (JNK) pathway scaffold protein, JNK Interacting Protein-1 (JIP1), by caspases during both Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and staurosporine-induced apoptosis in HeLa cells.	Staurosporine	218-231	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	91-116
21237154-1	2011	We report here the cleavage of the c-Jun N-terminal Kinase (JNK) pathway scaffold protein, JNK Interacting Protein-1 (JIP1), by caspases during both Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and staurosporine-induced apoptosis in HeLa cells.	Staurosporine	218-231	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	118-122
21237154-1	2011	We report here the cleavage of the c-Jun N-terminal Kinase (JNK) pathway scaffold protein, JNK Interacting Protein-1 (JIP1), by caspases during both Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and staurosporine-induced apoptosis in HeLa cells.	Staurosporine	218-231	TNF superfamily member 10	Homo sapiens	149-205
21237154-1	2011	We report here the cleavage of the c-Jun N-terminal Kinase (JNK) pathway scaffold protein, JNK Interacting Protein-1 (JIP1), by caspases during both Tumour Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) and staurosporine-induced apoptosis in HeLa cells.	Staurosporine	218-231	TNF superfamily member 10	Homo sapiens	207-212
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Staurosporine	70-83	TAR DNA binding protein	Homo sapiens	137-143
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Staurosporine	70-83	TAR DNA binding protein	Homo sapiens	187-193
21339291-7	2011	Here, we further found that the ER (endoplasmic reticulum) stress- or staurosporine-mediated activation of caspases leads to cleavage of TDP-43 at Asp(89) and Asp(169), generating CTF35 (TDP-43-(90-414)) and CTF27 (TDP-43-(170-414)) in cultured neuronal cells.	Staurosporine	70-83	TAR DNA binding protein	Homo sapiens	187-193
21147196-11	2011	Inhibition of SIK by staurosporine elevates StAR transcription and TORC recruitment to maximum levels, but without CREB phosphorylation.	Staurosporine	21-34	salt inducible kinase 1	Homo sapiens	14-17
21147196-11	2011	Inhibition of SIK by staurosporine elevates StAR transcription and TORC recruitment to maximum levels, but without CREB phosphorylation.	Staurosporine	21-34	steroidogenic acute regulatory protein	Homo sapiens	44-48
21147196-15	2011	Staurosporine stimulation through SIK inhibition is repeated in cAMP stimulation of many steroidogenic genes regulated by steroidogenic factor 1 (SF-1) and CREB.	Staurosporine	0-13	salt inducible kinase 1	Homo sapiens	34-37
21147196-15	2011	Staurosporine stimulation through SIK inhibition is repeated in cAMP stimulation of many steroidogenic genes regulated by steroidogenic factor 1 (SF-1) and CREB.	Staurosporine	0-13	splicing factor 1	Homo sapiens	122-150
21147196-15	2011	Staurosporine stimulation through SIK inhibition is repeated in cAMP stimulation of many steroidogenic genes regulated by steroidogenic factor 1 (SF-1) and CREB.	Staurosporine	0-13	cAMP responsive element binding protein 1	Homo sapiens	156-160
21219955-8	2011	By contrast, staurosporine affected both clean and infected cells, causing apoptotic damage (cell shrinkage, nuclear apoptotic alterations, caspase-3 activation and caspase-promoted proteolysis, without PI permeability, and without effect on XTT reduction).	Staurosporine	13-26	caspase 3	Homo sapiens	140-149
21278133-9	2011	GLP-1 (100 nM) partially inhibited staurosporine-induced mitochondrial membrane depolarization and completely blocked the rest of the staurosporine-induced apoptotic changes.	Staurosporine	35-48	glucagon	Homo sapiens	0-5
21278133-9	2011	GLP-1 (100 nM) partially inhibited staurosporine-induced mitochondrial membrane depolarization and completely blocked the rest of the staurosporine-induced apoptotic changes.	Staurosporine	134-147	glucagon	Homo sapiens	0-5
21464892-5	2011	Recombinant KLK6 was shown to significantly reduce cell death under resting conditions and in response to camptothecin, dexamethasone, staurosporine and Fas-ligand.	Staurosporine	135-148	kallikrein related peptidase 6	Homo sapiens	12-16
21256122-6	2011	Furthermore, the increased formation of intracellular alpha-synuclein aggregates, which predominantly contain SUMOylated alpha-synuclein, significantly reduces the death of fibroblast cells in response to staurosporine.	Staurosporine	205-218	synuclein alpha	Homo sapiens	54-69
21256122-6	2011	Furthermore, the increased formation of intracellular alpha-synuclein aggregates, which predominantly contain SUMOylated alpha-synuclein, significantly reduces the death of fibroblast cells in response to staurosporine.	Staurosporine	205-218	synuclein alpha	Homo sapiens	121-136
21388543-3	2011	RESULTS: We report that both receptors translocate into the mitochondria of human glioblastoma and breast cancer cells, following treatments with the apoptosis inducers, staurosporine and anisomycin, and with an EGFR kinase inhibitor.	Staurosporine	170-183	epidermal growth factor receptor	Homo sapiens	212-216
21317875-4	2011	We show that the Xbp1-specific ribonuclease activity depends on autophosphorylation, and that ATP-competitive inhibitors staurosporin and sunitinib, which inhibit autophosphorylation in vitro, also inhibit Xbp1 splicing in vivo.	Staurosporine	121-133	X-box binding protein 1	Homo sapiens	17-21
21317875-4	2011	We show that the Xbp1-specific ribonuclease activity depends on autophosphorylation, and that ATP-competitive inhibitors staurosporin and sunitinib, which inhibit autophosphorylation in vitro, also inhibit Xbp1 splicing in vivo.	Staurosporine	121-133	X-box binding protein 1	Homo sapiens	206-210
21781517-4	2011	PKC inhibitor staurosporine (STS) and ERK1/2 inhibitor PD98059 were used to detect PKC or ERK1/2 function on the expression of PAI-1 in HUVECs induced by nicotine.	Staurosporine	14-27	serpin family E member 1	Homo sapiens	127-132
21781517-4	2011	PKC inhibitor staurosporine (STS) and ERK1/2 inhibitor PD98059 were used to detect PKC or ERK1/2 function on the expression of PAI-1 in HUVECs induced by nicotine.	Staurosporine	29-32	serpin family E member 1	Homo sapiens	127-132
21347609-0	2011	Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements.	Staurosporine	70-83	checkpoint kinase 1	Homo sapiens	172-176
21347609-0	2011	Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements.	Staurosporine	70-83	H2A.X variant histone	Homo sapiens	215-219
21093407-3	2011	In this study, we found that staurosporine (apoptosis-inducer)-induced HMGB1 release was associated with nucleosomal DNA fragmentation catalyzed by caspase-activated DNase (CAD) in WEHI-231 cells.	Staurosporine	29-42	high mobility group box 1	Mus musculus	71-76
21359199-10	2011	Furthermore, EBs formed from Tim-knockdown cells demonstrated resistance to staurosporine-induced apoptosis, consistent with a link between Tim and programmed cell death during cavitation.	Staurosporine	76-89	timeless circadian regulator	Homo sapiens	29-32
20654639-7	2010	Furthermore, pretreatment of oocytes with staurosporine, a PKC inhibitor, significantly decreased EAAC1 activity (1.00+-0.06 to 0.70+-0.05 muC; P&lt;0.05).	Staurosporine	42-55	solute carrier family 1 member 1	Rattus norvegicus	98-103
21052840-6	2011	Under the same experimental condition, the expression of both Bcl-2 and Bcl-xl was clearly induced by GM-CSF regardless of staurosporine treatment in RT-PCR and Western blot analyses.	Staurosporine	123-136	B cell leukemia/lymphoma 2	Mus musculus	62-67
21052840-6	2011	Under the same experimental condition, the expression of both Bcl-2 and Bcl-xl was clearly induced by GM-CSF regardless of staurosporine treatment in RT-PCR and Western blot analyses.	Staurosporine	123-136	BCL2-like 1	Mus musculus	72-78
20862502-4	2011	Adenoviral CCM3 expression does not induce apoptosis under normal endothelial cell culture conditions but protects endothelial cells from staurosporine-induced cell death.	Staurosporine	138-151	programmed cell death 10	Homo sapiens	11-15
22069492-4	2011	In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt.	Staurosporine	15-28	protein tyrosine kinase 2	Homo sapiens	154-175
22069492-4	2011	In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt.	Staurosporine	15-28	protein tyrosine kinase 2	Homo sapiens	177-180
22069492-4	2011	In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt.	Staurosporine	15-28	AKT serine/threonine kinase 1	Homo sapiens	256-259
22069492-4	2011	In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt.	Staurosporine	30-33	protein tyrosine kinase 2	Homo sapiens	154-175
22069492-4	2011	In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt.	Staurosporine	30-33	protein tyrosine kinase 2	Homo sapiens	177-180
22069492-4	2011	In this study, staurosporine (STS) treatment induced human keratinocyte (HaCaT) e-lam formation on fibronectin matrix and migration via the activation of focal adhesion kinase (FAK), the surge of intracellular calcium level [Ca2+]i and the inactivation of Akt.	Staurosporine	30-33	AKT serine/threonine kinase 1	Homo sapiens	256-259
21829721-6	2011	VRK1 is more sensitive to staurosporine, RO-31-8220 and TDZD8.	Staurosporine	26-39	VRK serine/threonine kinase 1	Homo sapiens	0-4
21829721-8	2011	Vaccinia virus B1R is more sensitive to staurosporine, KU55933, and RO 31-8220, but not to IC261.	Staurosporine	40-53	ser/thr kinase	Vaccinia virus	15-18
21185940-6	2011	It lowered levels of cyclin kinase inhibitor p21, affected G1 to S phase cell cycle transition; partially blocked the elevation in p53 transcriptional activity, p21 and Bcl-2-associated X protein (Bax) levels caused by bleomycin, but had no influence on enhancement of Bax in response to staurosporine.	Staurosporine	288-301	transformation related protein 53, pseudogene	Mus musculus	131-134
21368884-4	2011	Intriguingly, we found that several human tumors upregulated PON2 and such overexpression provided resistance to different chemotherapeutics (imatinib, doxorubicine, staurosporine, or actinomycin) in cell culture models.	Staurosporine	166-179	paraoxonase 2	Homo sapiens	61-65
21368885-3	2011	We have studied the effect of staurosporine (STS), a well-established apoptosis inducer, on the membrane potential of HeLa cells to determine the nature of STS-activated ion conductances and their role in the activation of different caspases.	Staurosporine	30-43	caspase 8	Homo sapiens	233-241
20821241-1	2011	The 3.15-A-resolution crystal structure of the R enantiomer of the highly bioactive and antiproliferative half-sandwich ruthenium complex DW12 bound to the ATP binding site of glycogen synthase kinase 3beta (GSK-3beta) is reported and the binding is compared with the GSK-3beta binding of staurosporine and other organic inhibitors.	Staurosporine	289-302	glycogen synthase kinase 3 beta	Homo sapiens	176-206
20926530-5	2011	Induced expression of BRAF(V600E) suppressed the apoptotic responses against staurosporine and TNFalpha/cycloheximide.	Staurosporine	77-90	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	22-27
21625174-3	2011	Intracellular active caspase-3 concentrations in response to staurosporine stimulation were approximately 35% higher (p &lt; 0.05) in EPCs from older (3.15 +- 0.29 pg/ml) compared with young (2.33 +- 0.24 pg/ml) men.	Staurosporine	61-74	caspase 3	Homo sapiens	21-30
21118999-6	2011	Additionally, Noa1-/- cells are impaired in staurosporine-induced apoptosis.	Staurosporine	44-57	nitric oxide associated 1	Mus musculus	14-18
21617754-0	2011	FKBP51 protects 661w cell culture from staurosporine-induced apoptosis.	Staurosporine	39-52	FK506 binding protein 5	Mus musculus	0-6
21617754-11	2011	RESULTS: FKBP51 overexpression significantly protected 661w cell cultures from staurosporine-induced apoptosis.	Staurosporine	79-92	FK506 binding protein 5	Mus musculus	9-15
21617754-15	2011	CONCLUSIONS: These results suggest that FKBP51 protects 661w cell cultures from apoptosis induced by staurosporine.	Staurosporine	101-114	FK506 binding protein 5	Mus musculus	40-46
22174825-6	2011	Although recombinant EBV with a deletion removing the BHRF1 locus--that encodes the BCL2-homologue BHRF1 and three microRNAs--partially abrogates protection against ionomycin and staurosporine, the deletion has no effect on the EBV-mediated block to NOXA accumulation.	Staurosporine	179-192	apoptosis regulator BHRF1	Human gammaherpesvirus 4	54-59
21980415-7	2011	We also demonstrated that treatment of MCF7/casp3-10b cells with staurosporine and etoposides induced apoptosis and knockdown of CAAP expression.	Staurosporine	65-78	caspase activity and apoptosis inhibitor 1	Homo sapiens	129-133
21915333-0	2011	Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis.	Staurosporine	111-124	heat shock protein family A (Hsp70) member 1A	Homo sapiens	23-28
21915333-3	2011	Thermal preconditioning (43 C for 30 min) induced Hsp72, leading to cellular protection against apoptosis induced by a subsequent treatment with staurosporine.	Staurosporine	145-158	heat shock protein family A (Hsp70) member 1A	Homo sapiens	50-55
21915333-4	2011	Preconditioned staurosporine-treated cells displayed decreased Bax recruitment to mitochondria and subsequent activation, as well as reduced cytochrome c redistribution from mitochondria.	Staurosporine	15-28	BCL2 associated X, apoptosis regulator	Homo sapiens	63-66
21915333-4	2011	Preconditioned staurosporine-treated cells displayed decreased Bax recruitment to mitochondria and subsequent activation, as well as reduced cytochrome c redistribution from mitochondria.	Staurosporine	15-28	cytochrome c, somatic	Homo sapiens	141-153
21915333-6	2011	Neuron-like cells (with elevated Hsp72) were more resistant to staurosporine by all measured indices of apoptotic signaling.	Staurosporine	63-76	heat shock protein family A (Hsp70) member 1A	Homo sapiens	33-38
21915333-7	2011	Use of stable transfectants ectopically expressing moderately elevated levels of Hsp72 revealed that such cells in the undifferentiated state showed enhanced resistance to staurosporine-induced apoptosis, which was even more robust after differentiation to neuron-like cells.	Staurosporine	172-185	heat shock protein family A (Hsp70) member 1A	Homo sapiens	81-86
21138812-5	2010	Both diltiazem (1 muM), an L-type Ca2+ channel blocker and ryanodine (10 nM), a sarcoplasmic reticulum (SR) Ca2+ release channel opener completely suppressed the rAmylin-induced positive inotropic effect, but staurosporine (100 nM), a potent protein kinase C (PKC) inhibitor suppressed it partially.	Staurosporine	209-222	islet amyloid polypeptide	Rattus norvegicus	162-169
20937380-9	2010	Overexpression of antiapoptotic Bcl-X(L) protected against staurosporine-induced cell death, but it failed to confer protection against menadione.	Staurosporine	59-72	BCL2 like 1	Homo sapiens	32-40
20864561-8	2010	CD31(+) T cells from middle-aged and older men demonstrated greater apoptotic susceptibility, as staurosporine-stimulated intracellular caspase-3 activation was ~ 40% higher (P &lt; 0.05) than young.	Staurosporine	97-110	platelet and endothelial cell adhesion molecule 1	Homo sapiens	0-4
20864561-8	2010	CD31(+) T cells from middle-aged and older men demonstrated greater apoptotic susceptibility, as staurosporine-stimulated intracellular caspase-3 activation was ~ 40% higher (P &lt; 0.05) than young.	Staurosporine	97-110	caspase 3	Homo sapiens	136-145
20869113-4	2010	Furthermore, we demonstrated that TRH and its analogues decreased the staurosporine (0.5 muM)-induced LDH release, caspase-3 activity and DNA fragmentation, which indicate the anti-apoptotic proprieties of these peptides.	Staurosporine	70-83	thyrotropin releasing hormone	Homo sapiens	34-37
20830735-3	2010	Here we report unprecedented detection of endogenous p10, the smaller proteolytic fragment of the Cdk5 activator p35 in treated primary cortical neurons that underwent significant apoptosis, triggered by proteasome inhibitors MG132 and lactacystin, and protein kinase inhibitor staurosporine (STS).	Staurosporine	278-291	S100 calcium binding protein A10	Homo sapiens	53-56
20830735-3	2010	Here we report unprecedented detection of endogenous p10, the smaller proteolytic fragment of the Cdk5 activator p35 in treated primary cortical neurons that underwent significant apoptosis, triggered by proteasome inhibitors MG132 and lactacystin, and protein kinase inhibitor staurosporine (STS).	Staurosporine	293-296	S100 calcium binding protein A10	Homo sapiens	53-56
20869113-4	2010	Furthermore, we demonstrated that TRH and its analogues decreased the staurosporine (0.5 muM)-induced LDH release, caspase-3 activity and DNA fragmentation, which indicate the anti-apoptotic proprieties of these peptides.	Staurosporine	70-83	latexin	Homo sapiens	89-92
20869113-4	2010	Furthermore, we demonstrated that TRH and its analogues decreased the staurosporine (0.5 muM)-induced LDH release, caspase-3 activity and DNA fragmentation, which indicate the anti-apoptotic proprieties of these peptides.	Staurosporine	70-83	caspase 3	Homo sapiens	115-124
20846156-9	2010	The addition of NAC, curcumin, PD98059, and staurosporine markedly inhibited the arecoline-induced HIF-1alpha expression (P&lt;0.05).	Staurosporine	44-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	99-109
20810912-8	2010	Conversely, staurosporine, a kinase inhibitor, and nutlin-3, a drug that enhances p53 expression, both raised p53 levels and increased the rate of apoptosis in syncytiotrophoblasts compared with vehicle controls.	Staurosporine	12-25	tumor protein p53	Homo sapiens	110-113
21115931-1	2010	(51)Cr-prelabelled colon cancer cells (simulating "circulating tumor cells", CTCs) were added to human peripheral blood and exposed to staurosporine (ST) to increase carcinoembryonic antigen (CEA) expression.	Staurosporine	150-152	CEA cell adhesion molecule 3	Homo sapiens	166-190
21121091-6	2010	Cleavage of Beclin 1 was also seen in apoptosis of HeLa cells induced by staurosporine and TRAIL, along with cleavage of Atg3 and Atg4C.	Staurosporine	73-86	beclin 1	Homo sapiens	12-20
20479785-4	2010	Upon exposure to ultraviolet light and staurosporine, AR underwent proteasomal degradation.	Staurosporine	39-52	androgen receptor	Homo sapiens	54-56
20693293-6	2010	Mutation of functionally important PKC phosphorylation sites on TRPV1, or application of staurosporine, a broad-spectrum kinase inhibitor, completely inhibited the effect of PKC in enhancing channel open time.	Staurosporine	89-102	proline rich transmembrane protein 2	Homo sapiens	174-177
20693293-7	2010	Staurosporine also inhibited channel activity in the absence of overt PKC activation, showing that TRPV1 is partially phosphorylated at rest.	Staurosporine	0-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	99-104
20846156-10	2010	CONCLUSIONS: Hypoxia inducible factor-1alpha expression is significantly upregulated in areca quid chewing-associated OSCC and HIF-1alpha expression induced by arecoline is downregulated by NAC, curcumin, PD98059, and staurosporine.	Staurosporine	218-231	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-137
20632993-5	2010	To provide a structural framework for understanding these mutations and to guide structure-assisted drug discovery efforts, the X-ray crystal structure of the unphosphorylated ALK catalytic domain was determined in the apo, ADP- and staurosporine-bound forms.	Staurosporine	233-246	ALK receptor tyrosine kinase	Homo sapiens	176-179
20886113-4	2010	METHODOLOGY: Forced expression of Hr by transfection decreased the number of apoptotic nuclei, levels of caspase-3 activity, and cytosolic cytochrome C in COS cells exposed to staurosporine and tunicamycin.	Staurosporine	176-189	lysine demethylase and nuclear receptor corepressor	Mus musculus	34-36
20338155-7	2010	Decreased apoptosis in siRNA AChE silenced myoblasts and increased AChE expression in staurosporine-treated myoblasts confirmed AChE involvement in apoptosis.	Staurosporine	86-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
21031022-4	2010	METHODS: Staurosporine differentiated retinal ganglion cells were treated with increasing doses of VEGF in the presence of hydrogen peroxide.	Staurosporine	9-22	vascular endothelial growth factor A	Homo sapiens	99-103
20338155-7	2010	Decreased apoptosis in siRNA AChE silenced myoblasts and increased AChE expression in staurosporine-treated myoblasts confirmed AChE involvement in apoptosis.	Staurosporine	86-99	acetylcholinesterase (Cartwright blood group)	Homo sapiens	67-71
20338155-8	2010	The three AChE splice variants were differently affected by staurosporine-induced apoptosis.	Staurosporine	60-73	acetylcholinesterase (Cartwright blood group)	Homo sapiens	10-14
20057362-11	2010	Staurosporine induced a ~30% greater (P &lt; 0.05) increase in active caspase-3 in EPCs from overweight/obese (2.8 +/- 0.2 ng/ml) compared with normal weight (2.2 +/- 0.2) subjects.	Staurosporine	0-13	caspase 3	Homo sapiens	70-79
20644345-0	2010	Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected].	Staurosporine	103-116	nerve growth factor	Homo sapiens	37-56
20644345-0	2010	Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected].	Staurosporine	103-116	brain derived neurotrophic factor	Homo sapiens	61-94
20644345-0	2010	Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7/IGF-IR [corrected].	Staurosporine	103-116	insulin like growth factor 1 receptor	Homo sapiens	156-162
20644345-2	2010	Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway is critical for protection of hippocampal cells from staurosporine (STS) induced apoptosis, characterized by nuclear condensation and activation of the caspase cascade.	Staurosporine	141-154	AKT serine/threonine kinase 1	Homo sapiens	76-79
20644345-2	2010	Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway is critical for protection of hippocampal cells from staurosporine (STS) induced apoptosis, characterized by nuclear condensation and activation of the caspase cascade.	Staurosporine	156-159	AKT serine/threonine kinase 1	Homo sapiens	76-79
20644345-7	2010	Thus, the survival action of NGF and BDNF against STS-induced neurotoxicity was mediated by the activation of PI3K/Akt signaling through the Trk receptor.	Staurosporine	50-53	nerve growth factor	Homo sapiens	29-32
20644345-7	2010	Thus, the survival action of NGF and BDNF against STS-induced neurotoxicity was mediated by the activation of PI3K/Akt signaling through the Trk receptor.	Staurosporine	50-53	brain derived neurotrophic factor	Homo sapiens	37-41
20644345-7	2010	Thus, the survival action of NGF and BDNF against STS-induced neurotoxicity was mediated by the activation of PI3K/Akt signaling through the Trk receptor.	Staurosporine	50-53	AKT serine/threonine kinase 1	Homo sapiens	115-118
20644345-7	2010	Thus, the survival action of NGF and BDNF against STS-induced neurotoxicity was mediated by the activation of PI3K/Akt signaling through the Trk receptor.	Staurosporine	50-53	neurotrophic receptor tyrosine kinase 1	Homo sapiens	141-144
20427266-5	2010	In vitro, the TAT-crmA fusion protein was efficiently translocated into target cells and inhibited apoptosis mediated through caspase-8, caspase-9, and caspase-3 after stimulation with alpha-Fas, etoposide, doxorubicin, or staurosporine.	Staurosporine	223-236	CrmA or CPXV207 protein	Cowpox virus	18-22
20551318-3	2010	We show that (i) PEs directly interact with the LID of NHE1 in vitro, (ii) like PKC, green fluorescent protein (GFP)-labeled LID translocates to the plasma membrane in response to PEs and receptor agonists, (iii) LID mutations markedly inhibit these interactions and PE/receptor agonist-induced NHE1 activation, and (iv) PKC inhibitors ineffectively block NHE1 activation, except staurosporin, which itself inhibits NHE1 via LID.	Staurosporine	380-392	solute carrier family 9 member A1	Homo sapiens	55-59
20808948-3	2010	Systematic pair-wise comparison of the staurosporine-binding site of the proto-oncogene Pim-1 kinase with 6,412 druggable protein-ligand binding sites suggested that the ATP-binding site of synapsin I may recognize the pan-kinase inhibitor staurosporine.	Staurosporine	39-52	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	88-93
20808948-3	2010	Systematic pair-wise comparison of the staurosporine-binding site of the proto-oncogene Pim-1 kinase with 6,412 druggable protein-ligand binding sites suggested that the ATP-binding site of synapsin I may recognize the pan-kinase inhibitor staurosporine.	Staurosporine	39-52	synapsin I	Homo sapiens	190-200
20808948-3	2010	Systematic pair-wise comparison of the staurosporine-binding site of the proto-oncogene Pim-1 kinase with 6,412 druggable protein-ligand binding sites suggested that the ATP-binding site of synapsin I may recognize the pan-kinase inhibitor staurosporine.	Staurosporine	240-253	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	88-93
20808948-3	2010	Systematic pair-wise comparison of the staurosporine-binding site of the proto-oncogene Pim-1 kinase with 6,412 druggable protein-ligand binding sites suggested that the ATP-binding site of synapsin I may recognize the pan-kinase inhibitor staurosporine.	Staurosporine	240-253	synapsin I	Homo sapiens	190-200
20808948-4	2010	Biochemical validation of this hypothesis was realized by competition experiments of staurosporine with ATP-gamma(35)S for binding to synapsin I.	Staurosporine	85-98	synapsin I	Homo sapiens	134-144
20808948-5	2010	Staurosporine, as well as three other inhibitors of protein kinases (cdk2, Pim-1 and casein kinase type 2), effectively bound to synapsin I with nanomolar affinities and promoted synapsin-induced F-actin bundling.	Staurosporine	0-13	cyclin dependent kinase 2	Homo sapiens	69-73
20808948-5	2010	Staurosporine, as well as three other inhibitors of protein kinases (cdk2, Pim-1 and casein kinase type 2), effectively bound to synapsin I with nanomolar affinities and promoted synapsin-induced F-actin bundling.	Staurosporine	0-13	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	75-80
20808948-5	2010	Staurosporine, as well as three other inhibitors of protein kinases (cdk2, Pim-1 and casein kinase type 2), effectively bound to synapsin I with nanomolar affinities and promoted synapsin-induced F-actin bundling.	Staurosporine	0-13	synapsin I	Homo sapiens	129-139
20619274-10	2010	Furthermore, the resistance of anticancer drugs can be decreased when the phosphorylation of T100 in Trx was blocked by staurosporine.	Staurosporine	120-133	thioredoxin	Homo sapiens	101-104
20687965-8	2010	Furthermore, we demonstrate that this specific silencing of DFF45 by miR-145 accounts, at least in part, for the staurosporine-induced tumor cell apoptosis in vitro.	Staurosporine	113-126	DNA fragmentation factor subunit alpha	Homo sapiens	60-65
20687965-8	2010	Furthermore, we demonstrate that this specific silencing of DFF45 by miR-145 accounts, at least in part, for the staurosporine-induced tumor cell apoptosis in vitro.	Staurosporine	113-126	microRNA 145	Homo sapiens	69-76
20331638-5	2010	We show that treatment of HEK293 cells with PMT inhibits staurosporine-mediated apoptosis through PI3K-dependent phosphorylation of Akt and constitutive expression of Pim-1 kinase.	Staurosporine	57-70	AKT serine/threonine kinase 1	Homo sapiens	132-135
20331638-7	2010	Only the combined inhibition of Akt and Pim reverses the PMT-induced protection from staurosporine-induced apoptosis.	Staurosporine	85-98	AKT serine/threonine kinase 1	Homo sapiens	32-35
20372962-4	2010	Cells with mitochondria fragmented by OPA3 did not undergo spontaneous apoptotic cell death, but were significantly sensitized to staurosporine- and TRAIL-induced apoptosis.	Staurosporine	130-143	outer mitochondrial membrane lipid metabolism regulator OPA3	Homo sapiens	38-42
20462799-4	2010	SJIA monocytes are less susceptible to anti-Fas-induced apoptosis and, upon activation of the mitochondrial pathway with staurosporine, show diminished Bid cleavage and Bcl-w down-regulation compared to controls.	Staurosporine	121-134	BH3 interacting domain death agonist	Homo sapiens	152-155
20462799-4	2010	SJIA monocytes are less susceptible to anti-Fas-induced apoptosis and, upon activation of the mitochondrial pathway with staurosporine, show diminished Bid cleavage and Bcl-w down-regulation compared to controls.	Staurosporine	121-134	BCL2 like 2	Homo sapiens	169-174
20537984-6	2010	As a result, Hip2 significantly blocked cell death induced by staurosporine and Smac.	Staurosporine	62-75	ubiquitin conjugating enzyme E2 K	Homo sapiens	13-17
20119833-4	2010	The staurosporine derivate PKC412 (Midostaurin) was found to be an effective inhibitor of the FLT3-RTK and is currently undergoing clinical trials for FLT3-mutated AML patients.	Staurosporine	4-17	fms related receptor tyrosine kinase 3	Homo sapiens	94-98
20119833-4	2010	The staurosporine derivate PKC412 (Midostaurin) was found to be an effective inhibitor of the FLT3-RTK and is currently undergoing clinical trials for FLT3-mutated AML patients.	Staurosporine	4-17	fms related receptor tyrosine kinase 3	Homo sapiens	151-155
20436341-0	2010	Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase.	Staurosporine	0-13	deoxycytidine kinase	Homo sapiens	111-131
20436341-6	2010	Staurosporine increased dCK activity about two-fold and the activity of thymidine kinase 2, which may also activate gemcitabine.	Staurosporine	0-13	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	24-27
20436341-7	2010	Staurosporine also directly increased dCK in cell free extracts.	Staurosporine	0-13	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	38-41
20436341-8	2010	Staurosporine decreased expression of the free transcription factor E2F and of ribonucleotide reductase (RNR), a target for gemcitabine inhibition.	Staurosporine	0-13	nuclear receptor subfamily 2 group E member 3	Homo sapiens	105-108
20436341-9	2010	In conclusion, staurosporine may potentiate gemcitabine by increasing dCK and decreasing E2F and RNR, which will lead to a more pronounced RNR inhibition.	Staurosporine	15-28	Calcium/calmodulin-dependent protein kinase II	Drosophila melanogaster	70-73
20436341-9	2010	In conclusion, staurosporine may potentiate gemcitabine by increasing dCK and decreasing E2F and RNR, which will lead to a more pronounced RNR inhibition.	Staurosporine	15-28	nuclear receptor subfamily 2 group E member 3	Homo sapiens	89-100
20436341-9	2010	In conclusion, staurosporine may potentiate gemcitabine by increasing dCK and decreasing E2F and RNR, which will lead to a more pronounced RNR inhibition.	Staurosporine	15-28	nuclear receptor subfamily 2 group E member 3	Homo sapiens	97-100
20420578-9	2010	RuR-mediated protection against apoptosis in T-REx-293 cells, as induced by staurosporine, was observed in cells expressing VDAC1 or dimeric wild-type VDAC1.	Staurosporine	76-89	voltage dependent anion channel 1	Homo sapiens	124-129
20420578-9	2010	RuR-mediated protection against apoptosis in T-REx-293 cells, as induced by staurosporine, was observed in cells expressing VDAC1 or dimeric wild-type VDAC1.	Staurosporine	76-89	voltage dependent anion channel 1	Homo sapiens	151-156
20463052-2	2010	We reported that group VIA Ca(2+)-independent phospholipase A(2) (iPLA(2)beta) localizes in and protects beta-cell mitochondria from oxidative damage during staurosporine-induced apoptosis.	Staurosporine	157-170	phospholipase A2, group VI	Mus musculus	66-77
20463052-4	2010	We show that islets isolated from iPLA(2)beta(-/-) mice are more sensitive to staurosporine-induced apoptosis than those from wild-type littermates and that 2 wk of daily ip administration of staurosporine to iPLA(2)beta(-/-) mice impairs both the animals" glucose tolerance and glucose-stimulated insulin secretion by their pancreatic islets.	Staurosporine	78-91	phospholipase A2, group VI	Mus musculus	34-45
20463052-4	2010	We show that islets isolated from iPLA(2)beta(-/-) mice are more sensitive to staurosporine-induced apoptosis than those from wild-type littermates and that 2 wk of daily ip administration of staurosporine to iPLA(2)beta(-/-) mice impairs both the animals" glucose tolerance and glucose-stimulated insulin secretion by their pancreatic islets.	Staurosporine	192-205	phospholipase A2, group VI	Mus musculus	34-45
20463052-4	2010	We show that islets isolated from iPLA(2)beta(-/-) mice are more sensitive to staurosporine-induced apoptosis than those from wild-type littermates and that 2 wk of daily ip administration of staurosporine to iPLA(2)beta(-/-) mice impairs both the animals" glucose tolerance and glucose-stimulated insulin secretion by their pancreatic islets.	Staurosporine	192-205	phospholipase A2, group VI	Mus musculus	209-220
20463052-6	2010	The mitochondrial antioxidant N-t-butyl hydroxylamine blocked staurosporine-induced cytochrome c release and caspase-3 activation in iPLA(2)beta(-/-) islets.	Staurosporine	62-75	phospholipase A2, group VI	Mus musculus	133-144
20333643-3	2010	In this study, based on real-time single-cell analysis, we demonstrated for the first time that LPLI inhibits staurosporine (STS)-induced cell apoptosis by inactivating the GSK-3beta/Bax pathway.	Staurosporine	110-123	glycogen synthase kinase 3 beta	Homo sapiens	173-182
20333643-3	2010	In this study, based on real-time single-cell analysis, we demonstrated for the first time that LPLI inhibits staurosporine (STS)-induced cell apoptosis by inactivating the GSK-3beta/Bax pathway.	Staurosporine	110-123	BCL2 associated X, apoptosis regulator	Homo sapiens	183-186
20333643-3	2010	In this study, based on real-time single-cell analysis, we demonstrated for the first time that LPLI inhibits staurosporine (STS)-induced cell apoptosis by inactivating the GSK-3beta/Bax pathway.	Staurosporine	125-128	glycogen synthase kinase 3 beta	Homo sapiens	173-182
20333643-3	2010	In this study, based on real-time single-cell analysis, we demonstrated for the first time that LPLI inhibits staurosporine (STS)-induced cell apoptosis by inactivating the GSK-3beta/Bax pathway.	Staurosporine	125-128	BCL2 associated X, apoptosis regulator	Homo sapiens	183-186
20333643-10	2010	Taken together, we conclude that LPLI protects against STS-induced apoptosis upstream of Bax translocation via the PI3K/Akt/GSK-3beta pathway.	Staurosporine	55-58	BCL2 associated X, apoptosis regulator	Homo sapiens	89-92
20333643-10	2010	Taken together, we conclude that LPLI protects against STS-induced apoptosis upstream of Bax translocation via the PI3K/Akt/GSK-3beta pathway.	Staurosporine	55-58	AKT serine/threonine kinase 1	Homo sapiens	120-123
20333643-10	2010	Taken together, we conclude that LPLI protects against STS-induced apoptosis upstream of Bax translocation via the PI3K/Akt/GSK-3beta pathway.	Staurosporine	55-58	glycogen synthase kinase 3 beta	Homo sapiens	124-133
20143425-3	2010	Here, we report that staurosporine (STS)-induced apoptosis induces caspase-8 and/or-2-dependent gamma-secretase activation.	Staurosporine	21-34	caspase 8	Homo sapiens	67-76
20143425-3	2010	Here, we report that staurosporine (STS)-induced apoptosis induces caspase-8 and/or-2-dependent gamma-secretase activation.	Staurosporine	36-39	caspase 8	Homo sapiens	67-76
20873225-7	2010	Protection against H2O2-induced oxidative stress and staurosporine-induced apoptosis was registered for both EPO-MSCs and 10U-MSCs, but the protective effects were higher for the EPO-MSCs than for the 10U-MSCs.	Staurosporine	53-66	erythropoietin	Homo sapiens	109-112
20873225-7	2010	Protection against H2O2-induced oxidative stress and staurosporine-induced apoptosis was registered for both EPO-MSCs and 10U-MSCs, but the protective effects were higher for the EPO-MSCs than for the 10U-MSCs.	Staurosporine	53-66	erythropoietin	Homo sapiens	179-182
20306295-8	2010	Pretreatment with PKC inhibitor: staurosporine (SP) led to a restoration of control uptake in several postnatal-days suggesting a relationship between amino acids system and PKC activation.	Staurosporine	33-46	protein kinase C, gamma	Rattus norvegicus	18-21
20306295-8	2010	Pretreatment with PKC inhibitor: staurosporine (SP) led to a restoration of control uptake in several postnatal-days suggesting a relationship between amino acids system and PKC activation.	Staurosporine	33-46	protein kinase C, gamma	Rattus norvegicus	174-177
20306295-8	2010	Pretreatment with PKC inhibitor: staurosporine (SP) led to a restoration of control uptake in several postnatal-days suggesting a relationship between amino acids system and PKC activation.	Staurosporine	48-50	protein kinase C, gamma	Rattus norvegicus	18-21
20306295-8	2010	Pretreatment with PKC inhibitor: staurosporine (SP) led to a restoration of control uptake in several postnatal-days suggesting a relationship between amino acids system and PKC activation.	Staurosporine	48-50	protein kinase C, gamma	Rattus norvegicus	174-177
20339915-5	2010	When cells were pretreated with staurosporine (an inhibitor of a variety of protein kinases including PKC), the up-regulation of c-gelsolin induced by A23187 was inhibited.	Staurosporine	32-45	gelsolin	Homo sapiens	131-139
20368335-2	2010	To address how Cdc25A promotes apoptosis, Jurkat cells were treated with staurosporine, an apoptosis inducer.	Staurosporine	73-86	cell division cycle 25A	Homo sapiens	15-21
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin dependent kinase 1	Homo sapiens	136-140
20368335-3	2010	Upon staurosporine treatment, a Cdc25A C-terminal 37-kDa fragment, designated C37, was generated by caspase cleavage at Asp-223.	Staurosporine	5-18	cell division cycle 25A	Homo sapiens	32-38
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin dependent kinase 2	Homo sapiens	142-146
20151195-8	2010	L-NAME, 5HD, N-acetylcysteine (NAC) and staurosporine inhibited ERK1/2 phosphorylation and also reduced pravastatin-induced cardioprotection, suggesting NO, mitochondrial K(ATP) (mitoK(ATP)) channels, ROS and PKC should be involved in the cardioprotective signaling.	Staurosporine	40-53	mitogen activated protein kinase 3	Rattus norvegicus	64-70
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin A2	Homo sapiens	148-156
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin B1	Homo sapiens	162-171
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin B1	Homo sapiens	195-204
20368335-6	2010	C37 with alanine substitution for Thr-507 (C37/T507A) that imitated the cleavage product during staurosporine treatment interacted with Cdc2, Cdk2, cyclin A, and cyclin B1 and markedly activated cyclin B1/Cdc2.	Staurosporine	96-109	cyclin dependent kinase 1	Homo sapiens	205-209
20368335-9	2010	Thus, this study reveals that Cdc25A is a pro-apoptotic protein that amplifies staurosporine-induced apoptosis through the activation of cyclin B1/Cdc2 by its C-terminal domain.	Staurosporine	79-92	cell division cycle 25A	Homo sapiens	30-36
20368335-9	2010	Thus, this study reveals that Cdc25A is a pro-apoptotic protein that amplifies staurosporine-induced apoptosis through the activation of cyclin B1/Cdc2 by its C-terminal domain.	Staurosporine	79-92	cyclin B1	Homo sapiens	137-146
20368335-9	2010	Thus, this study reveals that Cdc25A is a pro-apoptotic protein that amplifies staurosporine-induced apoptosis through the activation of cyclin B1/Cdc2 by its C-terminal domain.	Staurosporine	79-92	cyclin dependent kinase 1	Homo sapiens	30-34
21364655-4	2010	Immunoprecipitation confirmed that C-XIAP-C retained the ability to interact with Smac and impaired extrinsically and intrinsically activated apoptosis in response to tumour necrosis factor-related apoptosis-inducing ligand/cycloheximide and staurosporine.	Staurosporine	242-255	X-linked inhibitor of apoptosis	Homo sapiens	37-41
19960021-8	2010	Treatment of fetal thymocytes with staurosporine, but not etoposide, induced processing of procaspases 3 and 9, indicating that the E14.5 thymocytes have the ability to undergo caspase-dependent apoptosis in an Apaf-1-independent manner.	Staurosporine	35-48	apoptotic peptidase activating factor 1	Mus musculus	211-217
20304034-8	2010	The activation of Raf-1 was found to be attenuated in the presence of H7/staurosporin.	Staurosporine	73-85	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	18-23
20478695-11	2010	Analysis using kinase inhibitors revealed that ligand-dependent induction of Blimp1, but not that of CYP1A1, is inhibited by staurosporine.	Staurosporine	125-138	PR domain containing 1, with ZNF domain	Mus musculus	77-83
20385969-8	2010	Finally, TDGF-1 protected H295R cells from apoptosis induced by staurosporine, causing a decrease in caspase-3 activity, a reduction in the inactivation of poly(ADP-ribose) polymerase, and an inhibition of DNA fragmentation, detected by the TUNEL reaction and fluorescence microscopy that was blocked by LY294002.	Staurosporine	64-77	teratocarcinoma-derived growth factor 1	Homo sapiens	9-15
20385969-8	2010	Finally, TDGF-1 protected H295R cells from apoptosis induced by staurosporine, causing a decrease in caspase-3 activity, a reduction in the inactivation of poly(ADP-ribose) polymerase, and an inhibition of DNA fragmentation, detected by the TUNEL reaction and fluorescence microscopy that was blocked by LY294002.	Staurosporine	64-77	caspase 3	Homo sapiens	101-110
20302886-7	2010	Staurosporine, which readily induced apoptosis in dPC12 cells, showed a similar increase in caspase-3 activity and the characteristic pattern of nuclear fragmentation.	Staurosporine	0-13	caspase 3	Rattus norvegicus	92-101
20299424-5	2010	BK-induced stimulation of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for protein kinase C (PKC).	Staurosporine	100-113	kininogen 1	Homo sapiens	0-2
20299424-5	2010	BK-induced stimulation of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for protein kinase C (PKC).	Staurosporine	100-113	solute carrier family 22 member 8	Homo sapiens	26-31
20299424-5	2010	BK-induced stimulation of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for protein kinase C (PKC).	Staurosporine	100-113	solute carrier family 22 member 8	Homo sapiens	72-77
20299424-5	2010	BK-induced stimulation of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for protein kinase C (PKC).	Staurosporine	100-113	protein kinase C delta	Homo sapiens	157-160
21204008-7	2010	PGRN knockdown cells were also more sensitized to staurosporine-induced apoptosis.	Staurosporine	50-63	granulin precursor	Homo sapiens	0-4
20507646-6	2010	RESULTS: The Ser/Thr kinase inhibitors H-7 and staurosporine inhibited S100A4-induced IkappaBalpha phosphorylation and subsequent NF-kappaB activation.	Staurosporine	47-60	NFKB inhibitor alpha	Homo sapiens	86-98
20353946-5	2010	Surprisingly, although in response to the apoptotic inducer staurosporine PKR itself is not phosphorylated, PKR triggers the cleavage of HuR via its downstream effector FADD that in turn activates the caspase-8/caspase-3 pathway.	Staurosporine	60-73	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	74-77
20507646-12	2010	The Ser/Thr kinase inhibitors H-7 and staurosporine attenuated S100A4-induced NF-kappaB activation and inhibited IKK-mediated phosphorylation of IkappaBalpha.	Staurosporine	38-51	nuclear factor kappa B subunit 1	Homo sapiens	78-87
20507646-6	2010	RESULTS: The Ser/Thr kinase inhibitors H-7 and staurosporine inhibited S100A4-induced IkappaBalpha phosphorylation and subsequent NF-kappaB activation.	Staurosporine	47-60	nuclear factor kappa B subunit 1	Homo sapiens	130-139
20507646-12	2010	The Ser/Thr kinase inhibitors H-7 and staurosporine attenuated S100A4-induced NF-kappaB activation and inhibited IKK-mediated phosphorylation of IkappaBalpha.	Staurosporine	38-51	NFKB inhibitor alpha	Homo sapiens	145-157
20502714-6	2010	However, CD133 knockdown did result in greater susceptibility to staurosporine-induced apoptosis (p = 0.01) and reduction in cell motility (p&lt;0.04).	Staurosporine	65-78	prominin 1	Homo sapiens	9-14
20502714-9	2010	Also greater resistance to staurosporine-induced apoptosis (p = 0.008), greater cell motility (p = 0.03) and greater colony forming efficiency was seen in the CD133+ population than the CD133- population in both 2D and 3D culture (p&lt;0.0001 and p&lt;0.003 respectively).	Staurosporine	27-40	prominin 1	Homo sapiens	159-164
20070854-3	2010	In our experimental conditions, only STA-treated cells showed the phenotype of mature megakaryocytes (MKs) including GPIbalpha expression, DNA endoreduplication, and formation of platelet-like structures.	Staurosporine	37-40	glycoprotein Ib platelet subunit alpha	Homo sapiens	117-126
20146001-7	2010	Time course experiments indicated that STS-induced particle release occurred as early as 2 h after treatment, with the early release MPs displaying low levels of binding of annexin V and propidium iodide (PI).	Staurosporine	39-42	annexin A5	Homo sapiens	173-182
20189983-9	2010	Bcl-2- and Mcl-1-mediated protection from apoptosis induced by staurosporine or etoposide was enhanced in cells expressing InsP(3)R, demonstrating that their interactions with InsP(3)R enable Bcl-2 and Mcl-1 to be fully efficacious anti-apoptotic mediators.	Staurosporine	63-76	BCL2 apoptosis regulator	Homo sapiens	0-5
20060930-6	2010	As expected, ANT3 enhanced mitochondria-mediated apoptosis in response to lonidamine, a mitochondriotoxic chemotherapeutic drug, and staurosporine, a protein kinase inhibitor.	Staurosporine	133-146	solute carrier family 25 member 6	Homo sapiens	13-17
20060930-10	2010	Finally, stable ANT4 overexpression protected cancer cells from lonidamine and staurosporine apoptosis in a manner independent of Bcl-2 expression.	Staurosporine	79-92	solute carrier family 25 member 31	Homo sapiens	16-20
20225234-4	2010	Exposure of undifferentiated cells to proapoptotic stimuli such as staurosporine, TNF-alpha, or hypoxia, significantly increased programmed cell death, which was prevented by previous treatment with Epo.	Staurosporine	67-80	erythropoietin	Homo sapiens	199-202
20358223-5	2010	In tomato protoplasts, SlAREB transiently transactivated luciferase reporter gene expression driven by AtRD29A (responsive to dehydration) and SlLAP (leucine aminopeptidase) promoters with exogenous ABA application, which was suppressed by the kinase inhibitor staurosporine, indicating that an ABA-dependent post-translational modification is required for the transactivation ability of SlAREB protein.	Staurosporine	261-274	ABA-response element binding factor AREB1	Solanum lycopersicum	23-29
20189983-9	2010	Bcl-2- and Mcl-1-mediated protection from apoptosis induced by staurosporine or etoposide was enhanced in cells expressing InsP(3)R, demonstrating that their interactions with InsP(3)R enable Bcl-2 and Mcl-1 to be fully efficacious anti-apoptotic mediators.	Staurosporine	63-76	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	11-16
20101227-4	2010	In this study, we found that jun N-terminal kinase (JNK) was activated in etoposide- and staurosporine-treated, but not serum-starved, Bax/Bak DKO cells, and that autophagic cell death was suppressed by the addition of a JNK inhibitor and by a dominant-negative mutant of JNK.	Staurosporine	89-102	mitogen-activated protein kinase 8	Mus musculus	29-50
20362274-8	2010	In AIF(R201 del) fibroblasts, staurosporine-induced parthanatos was markedly increased, whereas re-expression of AIF(wt) induced recovery of RC activities.	Staurosporine	30-43	apoptosis inducing factor mitochondria associated 1	Homo sapiens	3-6
20101227-4	2010	In this study, we found that jun N-terminal kinase (JNK) was activated in etoposide- and staurosporine-treated, but not serum-starved, Bax/Bak DKO cells, and that autophagic cell death was suppressed by the addition of a JNK inhibitor and by a dominant-negative mutant of JNK.	Staurosporine	89-102	mitogen-activated protein kinase 8	Mus musculus	52-55
20101227-4	2010	In this study, we found that jun N-terminal kinase (JNK) was activated in etoposide- and staurosporine-treated, but not serum-starved, Bax/Bak DKO cells, and that autophagic cell death was suppressed by the addition of a JNK inhibitor and by a dominant-negative mutant of JNK.	Staurosporine	89-102	mitogen-activated protein kinase 8	Mus musculus	221-224
20101227-4	2010	In this study, we found that jun N-terminal kinase (JNK) was activated in etoposide- and staurosporine-treated, but not serum-starved, Bax/Bak DKO cells, and that autophagic cell death was suppressed by the addition of a JNK inhibitor and by a dominant-negative mutant of JNK.	Staurosporine	89-102	mitogen-activated protein kinase 8	Mus musculus	221-224
20012365-7	2010	However, requiem sensitized the cells to increased caspase-9 activities under staurosporine-induced apoptosis, suggesting that it has a role to play in mitochondria-mediated apoptosis under staurosporine treatment.	Staurosporine	78-91	caspase-9	Cricetulus griseus	51-60
20012365-7	2010	However, requiem sensitized the cells to increased caspase-9 activities under staurosporine-induced apoptosis, suggesting that it has a role to play in mitochondria-mediated apoptosis under staurosporine treatment.	Staurosporine	190-203	caspase-9	Cricetulus griseus	51-60
20352108-2	2010	This study demonstrates that human CysC is neuroprotective in cultures exposed to cytotoxic challenges, including nutritional-deprivation, colchicine, staurosporine, and oxidative stress.	Staurosporine	151-164	cystatin C	Homo sapiens	35-39
19962978-4	2010	LIF treatment significantly reduced staurosporine-induced apoptotic DNA fragmentation by 37% compared to control and also reduced the proteolytic activation of caspase-3 by 40% compared to control.	Staurosporine	36-49	leukemia inhibitory factor	Mus musculus	0-3
20099905-4	2010	In order to validate distinct inhibitors that target this enzyme and improve our understanding of nucleotide binding site architecture, we now report a biophysical and structural evaluation of the Mps1 catalytic domain in the presence of ATP and the aspecific model kinase inhibitor staurosporine.	Staurosporine	283-296	TTK protein kinase	Homo sapiens	197-201
19962979-11	2010	Moreover, FGF-8b opposed staurosporine-induced S115 cell death which effect was blocked by inhibiting the PI3K/Akt pathway but not the ERK/MAPK pathway.	Staurosporine	25-38	AKT serine/threonine kinase 1	Homo sapiens	111-114
20138823-6	2010	Moreover, we detected cyclophilin A-cytochrome c complexes within the cytoplasm of HCT116 cells following staurosporine-induced apoptosis.	Staurosporine	106-119	cytochrome c, somatic	Homo sapiens	36-48
20191354-4	2010	Staurosporine (160 nM) and H-7 (200 nM) downregulated the cellular NF-kappaB activation up to 20 and 60% compared to the NF-kappaB activity that was upregulated by NMU (5 microM) and NEU (5 microM), respectively.	Staurosporine	0-13	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	183-186
19840952-4	2010	METHODS AND RESULTS: CX3CL1 significantly reduces staurosporine-induced apoptosis of CASMC, as quantified by caspase 3 immunostaining and Annexin-V flow cytometry.	Staurosporine	50-63	C-X3-C motif chemokine ligand 1	Homo sapiens	21-27
19840952-4	2010	METHODS AND RESULTS: CX3CL1 significantly reduces staurosporine-induced apoptosis of CASMC, as quantified by caspase 3 immunostaining and Annexin-V flow cytometry.	Staurosporine	50-63	caspase 3	Homo sapiens	109-118
19901272-2	2010	We previously reported that staurosporine (STS), a broad-spectrum kinase inhibitor and prototypical apoptosis-inducing agent, produced p53-dependent, Bax-dependent, neural precursor cell (NPC) apoptosis, but that this effect occurred independently of new gene transcription and PUMA expression.	Staurosporine	28-41	transformation related protein 53, pseudogene	Mus musculus	135-138
19901272-2	2010	We previously reported that staurosporine (STS), a broad-spectrum kinase inhibitor and prototypical apoptosis-inducing agent, produced p53-dependent, Bax-dependent, neural precursor cell (NPC) apoptosis, but that this effect occurred independently of new gene transcription and PUMA expression.	Staurosporine	28-41	BCL2-associated X protein	Mus musculus	150-153
19901272-2	2010	We previously reported that staurosporine (STS), a broad-spectrum kinase inhibitor and prototypical apoptosis-inducing agent, produced p53-dependent, Bax-dependent, neural precursor cell (NPC) apoptosis, but that this effect occurred independently of new gene transcription and PUMA expression.	Staurosporine	43-46	transformation related protein 53, pseudogene	Mus musculus	135-138
19901272-2	2010	We previously reported that staurosporine (STS), a broad-spectrum kinase inhibitor and prototypical apoptosis-inducing agent, produced p53-dependent, Bax-dependent, neural precursor cell (NPC) apoptosis, but that this effect occurred independently of new gene transcription and PUMA expression.	Staurosporine	43-46	BCL2-associated X protein	Mus musculus	150-153
19901272-5	2010	Confocal microscopy analysis of STS-treated cells revealed partial colocalization of p53 with the mitochondrial marker pyruvate dehydrogenase as well as with conformationally altered "activated" Bax, suggesting an interaction between these proapoptotic molecules in triggering apoptotic death.	Staurosporine	32-35	transformation related protein 53, pseudogene	Mus musculus	85-88
19901272-5	2010	Confocal microscopy analysis of STS-treated cells revealed partial colocalization of p53 with the mitochondrial marker pyruvate dehydrogenase as well as with conformationally altered "activated" Bax, suggesting an interaction between these proapoptotic molecules in triggering apoptotic death.	Staurosporine	32-35	BCL2-associated X protein	Mus musculus	195-198
19923143-5	2010	Inhibition of MAPK p42/p44 by PD98059 partially reduced HG and BK induction of IL-6, CCL-2 and TGF-beta, whereas inhibition of PKC by staurosporine partially reduced HG- but not BK-induced overexpression of these cytokines and that of VEGF.	Staurosporine	134-147	proline rich transmembrane protein 2	Homo sapiens	127-130
19923143-6	2010	Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression.	Staurosporine	0-13	interleukin 6	Homo sapiens	70-74
19923143-6	2010	Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression.	Staurosporine	0-13	C-C motif chemokine ligand 2	Homo sapiens	76-81
19923143-6	2010	Staurosporine and PD98059 synergistically reduced the effect of HG on IL-6, CCL-2 and TGF-beta expression.	Staurosporine	0-13	transforming growth factor beta 1	Homo sapiens	86-94
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	Staurosporine	108-121	protein kinase C, gamma	Rattus norvegicus	32-48
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	Staurosporine	108-121	protein kinase C, gamma	Rattus norvegicus	50-53
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	Staurosporine	108-121	protein kinase C, gamma	Rattus norvegicus	60-63
20032465-7	2010	Sphingosine is known to inhibit protein kinase C (PKC), and PKC inhibition with nanomolar concentrations of staurosporine, calphostin C, and GF109203X down-regulated surface expression of S1P(1) but not S1P(4) in transfected rat hepatoma HTC(4) cells.	Staurosporine	108-121	sphingosine-1-phosphate receptor 1	Rattus norvegicus	188-194
20037155-8	2010	Moreover, expression of the VDAC1-based peptides in cells over-expressing Bcl-2 prevented Bcl-2-mediated protection against staurosporine-induced apoptotic cell death.	Staurosporine	124-137	voltage dependent anion channel 1	Homo sapiens	28-33
20037155-8	2010	Moreover, expression of the VDAC1-based peptides in cells over-expressing Bcl-2 prevented Bcl-2-mediated protection against staurosporine-induced apoptotic cell death.	Staurosporine	124-137	BCL2 apoptosis regulator	Homo sapiens	74-79
20037155-8	2010	Moreover, expression of the VDAC1-based peptides in cells over-expressing Bcl-2 prevented Bcl-2-mediated protection against staurosporine-induced apoptotic cell death.	Staurosporine	124-137	BCL2 apoptosis regulator	Homo sapiens	90-95
20048146-9	2010	Staurosporine, tumor necrosis factor-alpha, or a Fas ligand inhibited both RVI and hypertonicity-induced Akt activation in a manner sensitive to a scavenger for reactive oxygen species (ROS).	Staurosporine	0-13	AKT serine/threonine kinase 1	Homo sapiens	105-108
19878671-5	2010	Angiotensin II induced inhibition of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for PKC, and with Go6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile), a PKCalpha-specific inhibitor.	Staurosporine	111-124	angiotensinogen	Homo sapiens	0-14
19878671-5	2010	Angiotensin II induced inhibition of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for PKC, and with Go6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile), a PKCalpha-specific inhibitor.	Staurosporine	111-124	solute carrier family 22 member 8	Homo sapiens	37-42
19878671-5	2010	Angiotensin II induced inhibition of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for PKC, and with Go6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile), a PKCalpha-specific inhibitor.	Staurosporine	111-124	solute carrier family 22 member 8	Homo sapiens	83-88
19878671-5	2010	Angiotensin II induced inhibition of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for PKC, and with Go6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile), a PKCalpha-specific inhibitor.	Staurosporine	111-124	protein kinase C alpha	Homo sapiens	150-153
19878671-5	2010	Angiotensin II induced inhibition of hOAT3 activity could be prevented by treating hOAT3-expressing cells with staurosporine, a general inhibitor for PKC, and with Go6976 (5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile), a PKCalpha-specific inhibitor.	Staurosporine	111-124	protein kinase C alpha	Homo sapiens	271-279
19903468-8	2010	We also showed that uPA expression was suppressed by PKC inhibitors (calphostin C and staurosporine) and induced by a PKC activator (PMA) in PC-3 cells, suggesting that the inhibition of uPA by bisphosphonates is involved in PKC inhibition.	Staurosporine	86-99	plasminogen activator, urokinase	Homo sapiens	20-23
19926637-6	2010	Treatment of cells with OPN followed by staurosporine (STS) showed that OPN protects the cells from STS-induced apoptosis.	Staurosporine	40-53	secreted phosphoprotein 1	Homo sapiens	72-75
19926637-6	2010	Treatment of cells with OPN followed by staurosporine (STS) showed that OPN protects the cells from STS-induced apoptosis.	Staurosporine	55-58	secreted phosphoprotein 1	Homo sapiens	72-75
19926637-6	2010	Treatment of cells with OPN followed by staurosporine (STS) showed that OPN protects the cells from STS-induced apoptosis.	Staurosporine	100-103	secreted phosphoprotein 1	Homo sapiens	24-27
19926637-6	2010	Treatment of cells with OPN followed by staurosporine (STS) showed that OPN protects the cells from STS-induced apoptosis.	Staurosporine	100-103	secreted phosphoprotein 1	Homo sapiens	72-75
19854260-8	2010	Neurotransmitter-induced NT-3 levels were susceptible (to varying degrees) to inhibition by H-89 (protein kinase A inhibitor) or staurosporin (protein kinase C inhibitor), which led us to conclude that downstream signaling responsible for the stimulation of NT-3 synthesis by monoamines in astrocytes consists of multiple, complex intracellular mechanisms involving the cAMP/protein kinase A pathway, activation of protein kinase C, as well as mobilization of Ca(2+) ions.	Staurosporine	129-141	neurotrophin 3	Rattus norvegicus	25-29
20010439-8	2010	In particular, the triple combination of cytochalasin D+LY294002+olomoucine was almost as effective as staurosporine in inducing caspase-3 activity and apoptosis.	Staurosporine	103-116	caspase 3	Homo sapiens	129-138
19593598-6	2010	Further analysis of a neuronal cell model SKNBE, transfected with the mutant senataxin proteins, reveals increased sensitivity also to staurosporine and excitotoxicity associated with the p.L114Del mutant only.	Staurosporine	135-148	senataxin	Homo sapiens	77-86
19699794-7	2010	Staurosporine, a PKC inhibitor, blocked ERK1/2 phosphorylation induced by H(2)O(2).	Staurosporine	0-13	mitogen-activated protein kinase 3	Homo sapiens	40-46
19965624-8	2010	We also found that adult RBCs treated with staurosporine, a protein kinase C (PKC) inhibitor, were sensitized to xTRAIL1.	Staurosporine	43-56	TNF superfamily member 10 S homeolog	Xenopus laevis	113-120
19880522-13	2010	Staurosporine stress of ID8 cells promoted endogenous Pyk2 nuclear accumulation and enhanced Pyk2 binding to p53.	Staurosporine	0-13	protein tyrosine kinase 2 beta	Homo sapiens	54-58
19880522-13	2010	Staurosporine stress of ID8 cells promoted endogenous Pyk2 nuclear accumulation and enhanced Pyk2 binding to p53.	Staurosporine	0-13	protein tyrosine kinase 2 beta	Homo sapiens	93-97
19880522-13	2010	Staurosporine stress of ID8 cells promoted endogenous Pyk2 nuclear accumulation and enhanced Pyk2 binding to p53.	Staurosporine	0-13	tumor protein p53	Homo sapiens	109-112
19880522-14	2010	Pyk2 knockdown potentiated ID8 cell death upon staurosporine addition.	Staurosporine	47-60	protein tyrosine kinase 2 beta	Homo sapiens	0-4
19633014-5	2010	Apoptotic stimulation induced by hypoxia/reoxygenation or staurosporine (1 microM) enhanced AIF release in H-CMs compared with non-hypertrophic cardiomyocytes (N-CMs).	Staurosporine	58-71	apoptosis inducing factor, mitochondria associated 1	Rattus norvegicus	92-95
20021258-7	2010	Staurosporine-differentiated RGC-5 cells extend neurite processes and express Thy 1.2 after 24 hr differentiation; they express NF-L after 1 and 3 days differentiation.	Staurosporine	0-13	thymus cell antigen 1, theta	Mus musculus	78-85
20009568-1	2010	In the present work, we demonstrate that microbial alkaloid staurosporine (STS) and Ro 31-8220, structurally related to STS protein kinase C inhibitor, caused development of membrane tubular extensions in human neutrophils upon adhesion to fibronectin-coated substrata.	Staurosporine	60-73	fibronectin 1	Homo sapiens	240-251
20009568-1	2010	In the present work, we demonstrate that microbial alkaloid staurosporine (STS) and Ro 31-8220, structurally related to STS protein kinase C inhibitor, caused development of membrane tubular extensions in human neutrophils upon adhesion to fibronectin-coated substrata.	Staurosporine	75-78	fibronectin 1	Homo sapiens	240-251
19782762-1	2010	In this study, it was shown that the mammalian sterile 20-like serine/threonine protein kinase 3 (Mst3) plays an essential role in the staurosporine-induced apoptosis of HeLa cells.	Staurosporine	135-148	serine/threonine kinase 24	Homo sapiens	98-102
19782762-10	2010	These results suggest that Mst3 may respond to staurosporine to trigger the caspase-independent apoptotic pathway by regulating the nuclear translocation of apoptosis-inducing factor and endonuclease G, and the nuclease activity associated with endonuclease G.	Staurosporine	47-60	serine/threonine kinase 24	Homo sapiens	27-31
19782762-10	2010	These results suggest that Mst3 may respond to staurosporine to trigger the caspase-independent apoptotic pathway by regulating the nuclear translocation of apoptosis-inducing factor and endonuclease G, and the nuclease activity associated with endonuclease G.	Staurosporine	47-60	endonuclease G	Homo sapiens	187-201
19782762-10	2010	These results suggest that Mst3 may respond to staurosporine to trigger the caspase-independent apoptotic pathway by regulating the nuclear translocation of apoptosis-inducing factor and endonuclease G, and the nuclease activity associated with endonuclease G.	Staurosporine	47-60	endonuclease G	Homo sapiens	245-259
20157239-5	2010	Staurosporine, a potent inhibitor of a variety of protein kinases including protein kinase C (PKC), also blocked the H(2)O(2)induced expression of cgelsolin.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	76-92
20157239-5	2010	Staurosporine, a potent inhibitor of a variety of protein kinases including protein kinase C (PKC), also blocked the H(2)O(2)induced expression of cgelsolin.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	94-97
20157239-6	2010	However, both H(2)O(2) and staurosporine activated the mitogen-activated protein kinases (MAPKs), i.e., c-Jun N-terminal kinase, P38, and extracellular signal-regulated kinase.	Staurosporine	27-40	mitogen-activated protein kinase 14	Homo sapiens	129-132
20157251-3	2010	Here, we observed that the cells bearing high level of the dephosphorylated tau at Tau-1 epitope were more vulnerable to the apoptosis induced by staurosporine, camptothecin, and hydrogen peroxide, though the general outcome of tau expression was still anti-apoptotic.	Staurosporine	146-159	microtubule associated protein tau	Homo sapiens	76-79
19885859-6	2010	The activation of NF-kappaB was collectively blocked by treatment with PKC inhibitor (staurosporine) as well as ERK1/2 inhibitor (PD98059), respectively.	Staurosporine	86-99	protein kinase C, gamma	Rattus norvegicus	71-74
19890372-7	2010	Conversely, knockdown of the endogenous miR-125b in the ETV6/RUNX1 leukemia cell line REH increased apoptosis after Doxorubicin and Staurosporine treatments.	Staurosporine	132-145	ets variant 6	Mus musculus	56-60
19890372-7	2010	Conversely, knockdown of the endogenous miR-125b in the ETV6/RUNX1 leukemia cell line REH increased apoptosis after Doxorubicin and Staurosporine treatments.	Staurosporine	132-145	runt related transcription factor 1	Mus musculus	61-66
19782762-2	2010	The staurosporine-induced apoptosis was reduced by around 65% by the selective knockdown of Mst3 in stable clones, HeLa(siMst3).	Staurosporine	4-17	serine/threonine kinase 24	Homo sapiens	92-96
19782762-4	2010	Accordingly, Mst3 was proposed to trigger a caspase-independent apoptotic pathway in response to staurosporine.	Staurosporine	97-110	serine/threonine kinase 24	Homo sapiens	13-17
19782762-7	2010	Furthermore, it was shown that staurosporine promoted the nuclear translocation of apoptosis-inducing factor and endonuclease G in HeLa cells.	Staurosporine	31-44	endonuclease G	Homo sapiens	113-127
19782762-8	2010	The nuclease activity associated with endonuclease G was also enhanced in response to staurosporine.	Staurosporine	86-99	endonuclease G	Homo sapiens	38-52
19782762-9	2010	However, both staurosporine-induced nuclear translocation of apoptosis-inducing factor and endonuclease G and the nuclease activity associated with endonuclease G were markedly reduced in Hela(siMst3).	Staurosporine	14-27	endonuclease G	Homo sapiens	91-105
19895572-4	2010	The CD98-induced aggregation was enhanced by the general protein kinase inhibitors GF109203X and staurosporin, and by specific PKC-alpha/-beta peptide inhibitor 19-27, but inhibited by PKC activators such as phorbol 12-myristate 13-acetate (PMA).	Staurosporine	97-109	solute carrier family 3 member 2	Homo sapiens	4-8
19895572-5	2010	PMA-inhibition was reversed by PKC inhibitors recognising the ATP-binding site in PKC (e.g. staurosporin, GF109203X and Go6983).	Staurosporine	92-104	protein kinase C alpha	Homo sapiens	31-34
19895572-5	2010	PMA-inhibition was reversed by PKC inhibitors recognising the ATP-binding site in PKC (e.g. staurosporin, GF109203X and Go6983).	Staurosporine	92-104	protein kinase C alpha	Homo sapiens	82-85
19826009-6	2009	In addition, brief application of the broad spectrum kinase inhibitor staurosporine ablates LRRK2 dimers and promotes LRRK2 high molecular weight oligomers.	Staurosporine	70-83	leucine rich repeat kinase 2	Homo sapiens	92-97
19826009-6	2009	In addition, brief application of the broad spectrum kinase inhibitor staurosporine ablates LRRK2 dimers and promotes LRRK2 high molecular weight oligomers.	Staurosporine	70-83	leucine rich repeat kinase 2	Homo sapiens	118-123
19767770-5	2009	RACK1-induced oligomerization of Bax is required for staurosporine-mediated cell death.	Staurosporine	53-66	receptor for activated C kinase 1	Homo sapiens	0-5
19850936-2	2009	Recombinant N1 inhibits staurosporine-induced caspase-3 activation by modulating p53 transcription and activity, whereas the PrP(c)-derived pathological fragment (N2) remains biologically inert.	Staurosporine	24-37	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	81-84
19767770-5	2009	RACK1-induced oligomerization of Bax is required for staurosporine-mediated cell death.	Staurosporine	53-66	BCL2 associated X, apoptosis regulator	Homo sapiens	33-36
19933934-6	2009	Similarly, suppression of Fra-2 by small interfering RNA prevented human microvascular endothelial cells from staurosporine-induced apoptosis and improved both the number of tubes and the cumulative tube lengths in the tube formation assay.	Staurosporine	110-123	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	26-31
19896375-0	2009	Structural insights into IKKbeta inhibition by natural products staurosporine and quercetin.	Staurosporine	64-77	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	25-32
19896375-1	2009	This Letter describes the results of two combined approaches: homology modeling and molecular docking studies, in order to propose the molecular basis of IKKbeta inhibition by staurosporine and quercetin as ATP-competitive inhibitors.	Staurosporine	176-189	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	154-161
19892919-4	2009	Neutrophil chemotaxis was significantly suppressed by the PDK1 inhibitor staurosporine.	Staurosporine	73-86	pyruvate dehydrogenase kinase 1	Homo sapiens	58-62
19895853-3	2009	In this work we address its mitochondrial localization and we demonstrate that a blockage of endogenous NOA36/ZNF330 expression by small-interfering RNA (siRNA) reduced apoptotic response to etoposide (ETO), camptothecin (CPT) and staurosporine (STS) but not to CH11 anti-Fas antibody or tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) in HeLa cells.	Staurosporine	231-244	zinc finger protein 330	Homo sapiens	104-109
19895853-3	2009	In this work we address its mitochondrial localization and we demonstrate that a blockage of endogenous NOA36/ZNF330 expression by small-interfering RNA (siRNA) reduced apoptotic response to etoposide (ETO), camptothecin (CPT) and staurosporine (STS) but not to CH11 anti-Fas antibody or tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) in HeLa cells.	Staurosporine	231-244	zinc finger protein 330	Homo sapiens	110-116
19895853-3	2009	In this work we address its mitochondrial localization and we demonstrate that a blockage of endogenous NOA36/ZNF330 expression by small-interfering RNA (siRNA) reduced apoptotic response to etoposide (ETO), camptothecin (CPT) and staurosporine (STS) but not to CH11 anti-Fas antibody or tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) in HeLa cells.	Staurosporine	246-249	zinc finger protein 330	Homo sapiens	104-109
19895853-3	2009	In this work we address its mitochondrial localization and we demonstrate that a blockage of endogenous NOA36/ZNF330 expression by small-interfering RNA (siRNA) reduced apoptotic response to etoposide (ETO), camptothecin (CPT) and staurosporine (STS) but not to CH11 anti-Fas antibody or tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) in HeLa cells.	Staurosporine	246-249	zinc finger protein 330	Homo sapiens	110-116
19698783-6	2009	However, inhibition of GSK3 reduced apoptosis and apoptosome formation, including the recruitments of caspase-9 and XIAP to Apaf-1, in response to staurosporine treatment.	Staurosporine	147-160	caspase 9	Homo sapiens	102-111
19698783-6	2009	However, inhibition of GSK3 reduced apoptosis and apoptosome formation, including the recruitments of caspase-9 and XIAP to Apaf-1, in response to staurosporine treatment.	Staurosporine	147-160	X-linked inhibitor of apoptosis	Homo sapiens	116-120
19698783-6	2009	However, inhibition of GSK3 reduced apoptosis and apoptosome formation, including the recruitments of caspase-9 and XIAP to Apaf-1, in response to staurosporine treatment.	Staurosporine	147-160	apoptotic peptidase activating factor 1	Homo sapiens	124-130
19692349-5	2009	In addition, cell permeable pentapeptides designed from Ku70, termed Bax-inhibiting peptides (BIPs), inhibited staurosporine-induced Bax translocation and cell death in mouse myogenic cells.	Staurosporine	111-124	X-ray repair complementing defective repair in Chinese hamster cells 6	Mus musculus	56-60
19692349-5	2009	In addition, cell permeable pentapeptides designed from Ku70, termed Bax-inhibiting peptides (BIPs), inhibited staurosporine-induced Bax translocation and cell death in mouse myogenic cells.	Staurosporine	111-124	BCL2-associated X protein	Mus musculus	69-72
19692349-5	2009	In addition, cell permeable pentapeptides designed from Ku70, termed Bax-inhibiting peptides (BIPs), inhibited staurosporine-induced Bax translocation and cell death in mouse myogenic cells.	Staurosporine	111-124	BCL2-associated X protein	Mus musculus	133-136
19891061-4	2009	Expression of both receptors is necessary for the protective action of NT on staurosporine-induced caspase-3 activity in -TC3 cells.	Staurosporine	77-90	caspase 3	Mus musculus	99-108
19486916-0	2009	Role of oxidative stress and JNK pathway in apoptotic death induced by potassium deprivation and staurosporine in cerebellar granule neurons.	Staurosporine	97-110	mitogen-activated protein kinase 8	Homo sapiens	29-32
19857493-3	2009	In contrast to the wt p53 cell lines, the mt p53-R175H cell line was resistant to staurosporine (STS)-mediated detachment and caspase-3 activation.	Staurosporine	82-95	tumor protein p53	Homo sapiens	45-48
19857493-3	2009	In contrast to the wt p53 cell lines, the mt p53-R175H cell line was resistant to staurosporine (STS)-mediated detachment and caspase-3 activation.	Staurosporine	97-100	tumor protein p53	Homo sapiens	45-48
19841168-6	2009	Accordingly, increased Mcl-1 protein stability and GM-CSF serum concentrations were shown to correlate with staurosporine-induced apoptosis resistance.	Staurosporine	108-121	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	23-28
19841168-6	2009	Accordingly, increased Mcl-1 protein stability and GM-CSF serum concentrations were shown to correlate with staurosporine-induced apoptosis resistance.	Staurosporine	108-121	colony stimulating factor 2	Homo sapiens	51-57
19716548-9	2009	In contrast, intrinsic apoptosis induced by staurosporine, resulted in dispersed cell blebs which were alpha-fodrin-negative.	Staurosporine	44-57	spectrin alpha, non-erythrocytic 1	Homo sapiens	103-115
19560459-14	2009	Like in vitro, GM-CSF counteracts the staurosporine-induced cell death in vivo and protects RGCs from axotomy-induced degeneration.	Staurosporine	38-51	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	15-21
19638400-6	2009	Although initial analysis indicates that mitochondrial recruitment of ectopically expressed Drp1 in response to staurosporine is unaffected by loss of SUMOylation, we find that Drp1 SUMOylation is enhanced in the context of the K38A mutation.	Staurosporine	112-125	dynamin 1 like	Homo sapiens	92-96
19530162-5	2009	Overexpression of Bcl-X(L) conferred resistance to staurosporine-mediated apoptosis.	Staurosporine	51-64	BCL2 like 1	Homo sapiens	18-26
19659659-5	2009	The ABI3 transactivation of RY is inhibited by staurosporine, by a PP2C phosphatase, and by a repressor of maturation genes, VAL1/HSI2.	Staurosporine	47-60	AP2/B3-like transcriptional factor family protein	Arabidopsis thaliana	4-8
19462233-5	2009	Neuroprotective effects of NMDA on St-induced apoptosis in CGC were attenuated by inhibitors of ERK/MAPK-signaling, PD 98059 and U0126 but not by NMDA receptor antagonists, AP-5 (100 microM) and MK-801 (1 microM) or by inhibitors of PI3-K/Akt pathway (LY 294002 and wortmannin).	Staurosporine	35-37	mitogen-activated protein kinase 3	Homo sapiens	96-99
19462233-5	2009	Neuroprotective effects of NMDA on St-induced apoptosis in CGC were attenuated by inhibitors of ERK/MAPK-signaling, PD 98059 and U0126 but not by NMDA receptor antagonists, AP-5 (100 microM) and MK-801 (1 microM) or by inhibitors of PI3-K/Akt pathway (LY 294002 and wortmannin).	Staurosporine	35-37	adaptor related protein complex 5 subunit beta 1	Homo sapiens	173-177
19462233-5	2009	Neuroprotective effects of NMDA on St-induced apoptosis in CGC were attenuated by inhibitors of ERK/MAPK-signaling, PD 98059 and U0126 but not by NMDA receptor antagonists, AP-5 (100 microM) and MK-801 (1 microM) or by inhibitors of PI3-K/Akt pathway (LY 294002 and wortmannin).	Staurosporine	35-37	AKT serine/threonine kinase 1	Homo sapiens	239-242
19563436-2	2009	Pre-incubation of Xenopus laevis oocytes expressing TaALMT1 with protein kinase inhibitors (K252a and staurosporine) strongly inhibited both basal and Al(3+)-enhanced TaALMT1-mediated inward currents (malate efflux).	Staurosporine	102-115	aluminum-activated malate transporter 1	Triticum aestivum	52-59
19563436-2	2009	Pre-incubation of Xenopus laevis oocytes expressing TaALMT1 with protein kinase inhibitors (K252a and staurosporine) strongly inhibited both basal and Al(3+)-enhanced TaALMT1-mediated inward currents (malate efflux).	Staurosporine	102-115	aluminum-activated malate transporter 1	Triticum aestivum	167-174
20067105-6	2009	The increase of CTGF protein was inhibited significantly by pre-incubation with Staurosporine (SP) and PD98059 (P &lt; 0.01).	Staurosporine	80-93	cellular communication network factor 2	Homo sapiens	16-20
20067105-2	2009	METHODS: The effect of TGF-beta1, Staurosporine, PD98059 and matrine on the expression of CTGF, CTGF mRNA, p-Smad2, and p-ERK1/2 were evaluated by Western blot in cultured HLF-02 cells.	Staurosporine	34-47	cellular communication network factor 2	Homo sapiens	90-94
20067105-2	2009	METHODS: The effect of TGF-beta1, Staurosporine, PD98059 and matrine on the expression of CTGF, CTGF mRNA, p-Smad2, and p-ERK1/2 were evaluated by Western blot in cultured HLF-02 cells.	Staurosporine	34-47	cellular communication network factor 2	Homo sapiens	96-100
19748889-3	2009	We have now evaluated the mechanisms by which GIP regulates the dynamic interactions between cytoplasmic bcl-2 family members and the mitochondria in INS-1 cells during apoptosis induced by treatment with staurosporine (STS), an activator of the mitochondria-mediated apoptotic pathway.	Staurosporine	205-218	gastric inhibitory polypeptide	Rattus norvegicus	46-49
19748889-3	2009	We have now evaluated the mechanisms by which GIP regulates the dynamic interactions between cytoplasmic bcl-2 family members and the mitochondria in INS-1 cells during apoptosis induced by treatment with staurosporine (STS), an activator of the mitochondria-mediated apoptotic pathway.	Staurosporine	220-223	gastric inhibitory polypeptide	Rattus norvegicus	46-49
19748889-4	2009	STS induced translocation of bad and bimEL, activation of mitochondrial bax, release of mitochondrial cytochrome c, cleavage of caspase-3, and apoptosis.	Staurosporine	0-3	BCL2 associated X, apoptosis regulator	Rattus norvegicus	72-75
19748889-4	2009	STS induced translocation of bad and bimEL, activation of mitochondrial bax, release of mitochondrial cytochrome c, cleavage of caspase-3, and apoptosis.	Staurosporine	0-3	caspase 3	Rattus norvegicus	128-137
19874629-0	2009	Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase C. BACKGROUND: The role of protein kinase C (PKC) in regulating the activity of phospholipase C (PLC) in neutrophils activated with the chemoattractant, platelet-activating factor (PAF, 20 and 200 nM), was probed in the current study using the selective PKC inhibitors, GF10903X (0.5 - 1 muM) and staurosporine (400 nM).	Staurosporine	448-461	proline rich transmembrane protein 2	Homo sapiens	0-16
19874629-0	2009	Protein kinase C promotes restoration of calcium homeostasis to platelet activating factor-stimulated human neutrophils by inhibition of phospholipase C. BACKGROUND: The role of protein kinase C (PKC) in regulating the activity of phospholipase C (PLC) in neutrophils activated with the chemoattractant, platelet-activating factor (PAF, 20 and 200 nM), was probed in the current study using the selective PKC inhibitors, GF10903X (0.5 - 1 muM) and staurosporine (400 nM).	Staurosporine	448-461	proline rich transmembrane protein 2	Homo sapiens	196-199
19706611-6	2009	Knockdown of GIT induced and accelerated caspase-dependent apoptosis in both unstimulated and staurosporine-treated cells, which was attenuated by wild-type GIT1 overexpression or pharmacological inhibitors of IP(3)R, but not by a mutant form of GIT1 that abrogates the interaction.	Staurosporine	94-107	GIT ArfGAP 1	Homo sapiens	157-161
19706611-6	2009	Knockdown of GIT induced and accelerated caspase-dependent apoptosis in both unstimulated and staurosporine-treated cells, which was attenuated by wild-type GIT1 overexpression or pharmacological inhibitors of IP(3)R, but not by a mutant form of GIT1 that abrogates the interaction.	Staurosporine	94-107	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	210-216
19706611-6	2009	Knockdown of GIT induced and accelerated caspase-dependent apoptosis in both unstimulated and staurosporine-treated cells, which was attenuated by wild-type GIT1 overexpression or pharmacological inhibitors of IP(3)R, but not by a mutant form of GIT1 that abrogates the interaction.	Staurosporine	94-107	GIT ArfGAP 1	Homo sapiens	246-250
19695215-8	2009	Norepinephrine also induced phosphorylation of ERK1/2, which was prevented by staurosporine treatment.	Staurosporine	78-91	mitogen activated protein kinase 3	Rattus norvegicus	47-53
19808974-4	2009	Here, we report that, on initiation of apoptosis in human cells by agents causing DNA DSB or by staurosporine or other agents, ARTEMIS binds to apoptotic chromatin together with DNA-PK and other DSB repair proteins.	Staurosporine	96-109	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	178-184
19661060-5	2009	The enhancement was inhibited by the PKC inhibitors staurosporine, bisindolylmaleimide I, and rottlerin or by mutation of the serine/threonine residues Ser(162), Thr(175), and Ser(189).	Staurosporine	52-65	proline rich transmembrane protein 2	Homo sapiens	37-40
19653100-9	2009	In addition, the chemotherapeutic agent staurosporine was seen to be more effective in inducing cell death by apoptosis in UCKL-1 depleted K562 cells compared with controls.	Staurosporine	40-53	uridine-cytidine kinase 1 like 1	Homo sapiens	123-129
19524566-0	2009	Brain-derived neurotrophic factor released from engineered mesenchymal stem cells attenuates glutamate- and hydrogen peroxide-mediated death of staurosporine-differentiated RGC-5 cells.	Staurosporine	144-157	brain derived neurotrophic factor	Mus musculus	0-33
19631747-5	2009	MMP-2 is upregulated after hUCB treatment in spinal cord injured rats and in spinal neurons injured either with staurosporine or hydrogen peroxide.	Staurosporine	112-125	matrix metallopeptidase 2	Rattus norvegicus	0-5
20067105-6	2009	The increase of CTGF protein was inhibited significantly by pre-incubation with Staurosporine (SP) and PD98059 (P &lt; 0.01).	Staurosporine	95-97	cellular communication network factor 2	Homo sapiens	16-20
19362768-7	2009	With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells.	Staurosporine	117-130	zinc finger protein 148	Homo sapiens	46-52
19657228-8	2009	Overexpression of IFNgammaR2 (wild type and IFNgammaR2(296-337)) rescued cells from etoposide and staurosporine, which are known to induce Bax-mediated cell death.	Staurosporine	98-111	BCL2 associated X, apoptosis regulator	Homo sapiens	139-142
19604147-1	2009	MST3 (mammalian sterile 20-like kinase 3) is a sterile 20 kinase reported to have a role in Fas-ligation- and staurosporine-induced cell death by unknown mechanism(s).	Staurosporine	110-123	serine/threonine kinase 24	Homo sapiens	0-4
19604147-1	2009	MST3 (mammalian sterile 20-like kinase 3) is a sterile 20 kinase reported to have a role in Fas-ligation- and staurosporine-induced cell death by unknown mechanism(s).	Staurosporine	110-123	serine/threonine kinase 24	Homo sapiens	16-40
19048252-10	2009	It is likely that the immunogenic Numb-1 peptide in MCF7 cells originated from Numb, [P]-lated by an unknown kinase, because staurosporine but not wortmannin and MAPK-inhibitors decreased peptide presentation.	Staurosporine	125-138	NUMB endocytic adaptor protein	Homo sapiens	34-38
19524691-1	2009	Treatment of P388D1, a macrophage-like cell line, with staurosporine triggered apoptosis through the activation of caspase-9 and caspase-3.	Staurosporine	55-68	caspase 9	Mus musculus	115-124
19524691-1	2009	Treatment of P388D1, a macrophage-like cell line, with staurosporine triggered apoptosis through the activation of caspase-9 and caspase-3.	Staurosporine	55-68	caspase 3	Mus musculus	129-138
19524691-2	2009	Unexpected effects of staurosporine on the induction of apoptosis were the activation of caspase-8, and an increase of the levels of TNF-alpha.	Staurosporine	22-35	caspase 8	Mus musculus	89-98
19524691-2	2009	Unexpected effects of staurosporine on the induction of apoptosis were the activation of caspase-8, and an increase of the levels of TNF-alpha.	Staurosporine	22-35	tumor necrosis factor	Mus musculus	133-142
19609857-4	2009	G292 cells revealed the expression of cleaved PARP after incubation with staurosporine for 3 hours.	Staurosporine	73-86	poly(ADP-ribose) polymerase 1	Homo sapiens	46-50
19609857-10	2009	Immunocytochemistry of monomethyl histone H3 K27 showed a weak signal in controls, a strong signal in staurosporine-treated tumor cells and a denser signal in the apoptotic cells.	Staurosporine	102-115	keratin 27	Homo sapiens	45-48
19735104-6	2009	While one phosphoinositide 3-kinases (PI-3) kinase inhibitor, LY294002, completely blocked the effect of TGF-beta1 on SHARP-2 mRNA expression in LLC-PK1 cells at a low concentration, other inhibitors, including PD98059, staurosporine, AG490, wortmannin, okadaic acid and rapamycin, had no effect.	Staurosporine	220-233	transforming growth factor beta 1	Sus scrofa	105-114
19558454-0	2009	Alpha A-crystallin and alpha B-crystallin, newly identified interaction proteins of protease-activated receptor-2, rescue astrocytes from C2-ceramide- and staurosporine-induced cell death.	Staurosporine	155-168	F2R like trypsin receptor 1	Homo sapiens	84-113
19558454-12	2009	Evidence is presented to show that PAR-2 activation and increased expression of alpha-crystallins reduced C2-ceramide- and staurosporine-induced cell death in astrocytes.	Staurosporine	123-136	F2R like trypsin receptor 1	Homo sapiens	35-40
19641023-5	2009	A similar mobilization of RE traffic mediated by SFKs, Cdc42 and Rab11a also contributed to Golgi fragmentation and to cell death progression in response to staurosporine, in a caspase-independent manner.	Staurosporine	157-170	cell division cycle 42	Homo sapiens	55-60
19641023-5	2009	A similar mobilization of RE traffic mediated by SFKs, Cdc42 and Rab11a also contributed to Golgi fragmentation and to cell death progression in response to staurosporine, in a caspase-independent manner.	Staurosporine	157-170	RAB11A, member RAS oncogene family	Homo sapiens	65-71
19360906-0	2009	NOX2 mediates apoptotic death induced by staurosporine but not by potassium deprivation in cerebellar granule neurons.	Staurosporine	41-54	cytochrome b-245, beta polypeptide	Mus musculus	0-4
19661292-0	2009	Induction of apoptosis by staurosporine involves the inhibition of expression of the major cell cycle proteins at the G(2)/m checkpoint accompanied by alterations in Erk and Akt kinase activities.	Staurosporine	26-39	mitogen-activated protein kinase 1	Homo sapiens	166-169
19661292-0	2009	Induction of apoptosis by staurosporine involves the inhibition of expression of the major cell cycle proteins at the G(2)/m checkpoint accompanied by alterations in Erk and Akt kinase activities.	Staurosporine	26-39	AKT serine/threonine kinase 1	Homo sapiens	174-177
19661292-9	2009	Treatment of U-937 cells with staurosporine at 1 microM for 24 hours, compared with 0.5 microM for 18 hours, appeared to kill the leukemic more efficiently cells and this dose and duration may specifically target p27, Erk and Akt pathways that are important for cancer cell survival and resistance to treatment.	Staurosporine	30-43	dynactin subunit 6	Homo sapiens	213-216
19661292-9	2009	Treatment of U-937 cells with staurosporine at 1 microM for 24 hours, compared with 0.5 microM for 18 hours, appeared to kill the leukemic more efficiently cells and this dose and duration may specifically target p27, Erk and Akt pathways that are important for cancer cell survival and resistance to treatment.	Staurosporine	30-43	mitogen-activated protein kinase 1	Homo sapiens	218-221
19661292-9	2009	Treatment of U-937 cells with staurosporine at 1 microM for 24 hours, compared with 0.5 microM for 18 hours, appeared to kill the leukemic more efficiently cells and this dose and duration may specifically target p27, Erk and Akt pathways that are important for cancer cell survival and resistance to treatment.	Staurosporine	30-43	AKT serine/threonine kinase 1	Homo sapiens	226-229
19483192-3	2009	We here showed that inhibition of RIF1 expression by small interfering RNA led to defective homologous recombination-mediated DNA double-strand break repair and sensitized cancer cells to camptothecin or staurosporine treatment.	Staurosporine	204-217	replication timing regulatory factor 1	Homo sapiens	34-38
19048252-10	2009	It is likely that the immunogenic Numb-1 peptide in MCF7 cells originated from Numb, [P]-lated by an unknown kinase, because staurosporine but not wortmannin and MAPK-inhibitors decreased peptide presentation.	Staurosporine	125-138	NUMB endocytic adaptor protein	Homo sapiens	79-83
19582370-3	2009	Neither treatment induced caspase-7 activity, but caspase-3 was activated by staurosporine but not H2O2.	Staurosporine	77-90	caspase 3	Homo sapiens	50-59
19440697-5	2009	The phosphorylation of STAT6 and GATA3 were collectively blocked by treatment with PKC inhibitor (staurosporine) as well as p44/42 MAPK inhibitor (PD 98059), respectively.	Staurosporine	98-111	signal transducer and activator of transcription 6	Mus musculus	23-28
19553469-3	2009	Overexpression of human (h)-GAAP suppressed staurosporine-induced, capacitative Ca(2+) influx from the extracellular space.	Staurosporine	44-57	transmembrane BAX inhibitor motif containing 4	Homo sapiens	28-32
19440697-5	2009	The phosphorylation of STAT6 and GATA3 were collectively blocked by treatment with PKC inhibitor (staurosporine) as well as p44/42 MAPK inhibitor (PD 98059), respectively.	Staurosporine	98-111	GATA binding protein 3	Mus musculus	33-38
19646263-15	2009	Specifically, the cytotoxicity of Docetaxel, Staurosporine and Rapamycin increased significantly (&gt;40% at IC50 dose) in IL-8 depleted cells as compared to that in C-siRNA transfected cells.	Staurosporine	45-58	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
19649203-6	2009	Accordingly, PDGF-Ralpha was found to mediate staurosporine cytotoxicity.	Staurosporine	46-59	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	13-24
19448405-3	2009	During apoptosis induced by death receptors agonists (TRAIL and FasL) and staurosporine, gamma-H2AX is initiated in the nuclear periphery immediately inside the nuclear envelope while total H2AX remains distributed throughout the nucleus.	Staurosporine	74-87	H2A.X variant histone	Homo sapiens	95-99
19556880-6	2009	Furthermore, VEGFR-3 overexpression promoted cellular survival under stress conditions induced by staurosporine treatment and led to anchorage-independent growth.	Staurosporine	98-111	fms related receptor tyrosine kinase 4	Homo sapiens	13-20
19604397-0	2009	Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation.	Staurosporine	0-13	epidermal growth factor receptor	Homo sapiens	23-26
19604397-0	2009	Staurosporine augments EGF-mediated EMT in PMC42-LA cells through actin depolymerisation, focal contact size reduction and Snail1 induction - a model for cross-modulation.	Staurosporine	0-13	snail family transcriptional repressor 1	Homo sapiens	123-129
19549685-7	2009	In living cells, DeltaN63 Atg4D stimulates the delipidation of GABARAP-L1, whereas siRNA silencing of the gene expressing Atg4D abrogates GABARAP-L1 autophagosome formation and sensitises cells to starvation and staurosporine-induced cell death.	Staurosporine	212-225	autophagy related 4D cysteine peptidase	Homo sapiens	122-127
19426707-6	2009	Surprisingly, TAF15 was cleaved at more than one site in staurosporine-treated Jurkat cells.	Staurosporine	57-70	TATA-box binding protein associated factor 15	Homo sapiens	14-19
19521778-5	2009	The immunoblot analysis showed that the staurosporine induced a decrease in p-Akt protein kinase level and that this effect was reversed by memantine treatment.	Staurosporine	40-53	AKT serine/threonine kinase 1	Homo sapiens	78-81
19521778-7	2009	Furthermore, the ELISA studies showed increased cellular and released BDNF protein level after combined treatment with memantine and staurosporine.	Staurosporine	133-146	brain derived neurotrophic factor	Homo sapiens	70-74
19152029-2	2009	tPA expression and activity were determined in vivo after SCI in rats and in vitro in rat embryonic spinal neurons in response to injury with staurosporine, hydrogen peroxide and glutamate.	Staurosporine	142-155	plasminogen activator, tissue type	Homo sapiens	0-3
19777329-1	2009	The release of cytochrome c from mitochondria induced by 10 microM thapsigargin was linked to rapid loss of the mitochondrial membrane potential whereas that induced by 50 nM staurosporine was mediated by Bax activation and occurred in polarized mitochondria.	Staurosporine	175-188	BCL2 associated X, apoptosis regulator	Rattus norvegicus	205-208
19427203-0	2009	Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses.	Staurosporine	10-24	Janus kinase 3	Mus musculus	74-78
19427203-1	2009	The synthesis and biological evaluation of JAK3 based staurosporine compounds is described.	Staurosporine	54-67	Janus kinase 3	Mus musculus	43-47
19448405-3	2009	During apoptosis induced by death receptors agonists (TRAIL and FasL) and staurosporine, gamma-H2AX is initiated in the nuclear periphery immediately inside the nuclear envelope while total H2AX remains distributed throughout the nucleus.	Staurosporine	74-87	H2A.X variant histone	Homo sapiens	190-194
19500428-3	2009	Here, we investigated the effect of staurosporine, a potent protein kinase C (PKC) inhibitor on the mobility and invasiveness of human lung adenocarcinoma A549 cells.	Staurosporine	36-49	protein kinase C alpha	Homo sapiens	78-81
19216720-0	2009	Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells.	Staurosporine	76-89	tumor protein p53	Homo sapiens	111-114
19500428-7	2009	Western blot analyses were performed to study the effect of staurosporine on the levels of PKC-alpha, integrin beta1, E-cadherin, and LnR.	Staurosporine	60-73	protein kinase C alpha	Homo sapiens	91-100
19500428-7	2009	Western blot analyses were performed to study the effect of staurosporine on the levels of PKC-alpha, integrin beta1, E-cadherin, and LnR.	Staurosporine	60-73	integrin subunit beta 1	Homo sapiens	102-116
19500428-7	2009	Western blot analyses were performed to study the effect of staurosporine on the levels of PKC-alpha, integrin beta1, E-cadherin, and LnR.	Staurosporine	60-73	cadherin 1	Homo sapiens	118-128
19500428-14	2009	In addition, the levels of MMP-9 and uPA decreased in cells treated with staurosporine.	Staurosporine	73-86	matrix metallopeptidase 9	Homo sapiens	27-32
19500428-14	2009	In addition, the levels of MMP-9 and uPA decreased in cells treated with staurosporine.	Staurosporine	73-86	proline rich acidic protein 1	Homo sapiens	37-40
19500428-16	2009	The staurosporine-mediated inhibition of PKC-alpha, induction of E-Cad expression, and decreased integrin beta1, LnR, MMP-9, and uPA levels could all possibly contribute to this biological process.	Staurosporine	4-17	protein kinase C alpha	Homo sapiens	41-50
19500428-16	2009	The staurosporine-mediated inhibition of PKC-alpha, induction of E-Cad expression, and decreased integrin beta1, LnR, MMP-9, and uPA levels could all possibly contribute to this biological process.	Staurosporine	4-17	cadherin 1	Homo sapiens	65-70
19500428-16	2009	The staurosporine-mediated inhibition of PKC-alpha, induction of E-Cad expression, and decreased integrin beta1, LnR, MMP-9, and uPA levels could all possibly contribute to this biological process.	Staurosporine	4-17	integrin subunit beta 1	Homo sapiens	97-111
19500428-16	2009	The staurosporine-mediated inhibition of PKC-alpha, induction of E-Cad expression, and decreased integrin beta1, LnR, MMP-9, and uPA levels could all possibly contribute to this biological process.	Staurosporine	4-17	matrix metallopeptidase 9	Homo sapiens	118-123
19500428-16	2009	The staurosporine-mediated inhibition of PKC-alpha, induction of E-Cad expression, and decreased integrin beta1, LnR, MMP-9, and uPA levels could all possibly contribute to this biological process.	Staurosporine	4-17	proline rich acidic protein 1	Homo sapiens	129-132
19216720-0	2009	Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells.	Staurosporine	76-89	tumor protein p53	Homo sapiens	121-124
19216720-2	2009	Our laboratory has reported that p53 is a key contributor of mitochondrial apoptosis in cervical carcinoma cells after staurosporine exposure.	Staurosporine	119-132	tumor protein p53	Homo sapiens	33-36
19216720-5	2009	RESULTS: Staurosporine can induce death of HeLa cells via a cytochrome c/caspase-9/caspase-3 mitochondrial-dependent apoptotic pathway and via a delayed caspase-independent pathway.	Staurosporine	9-22	cytochrome c, somatic	Homo sapiens	60-72
19216720-5	2009	RESULTS: Staurosporine can induce death of HeLa cells via a cytochrome c/caspase-9/caspase-3 mitochondrial-dependent apoptotic pathway and via a delayed caspase-independent pathway.	Staurosporine	9-22	caspase 9	Homo sapiens	73-82
19216720-5	2009	RESULTS: Staurosporine can induce death of HeLa cells via a cytochrome c/caspase-9/caspase-3 mitochondrial-dependent apoptotic pathway and via a delayed caspase-independent pathway.	Staurosporine	9-22	caspase 3	Homo sapiens	83-92
19216720-8	2009	Meanwhile, the use of 3-aminobenzamide, a PARP-1 inhibitor known to prevent AIF (apoptosis-inducing factor) release, significantly decreases staurosporine-induced death in these p53mt carcinoma cells, suggesting a preferential implication of caspase-independent apoptosis.	Staurosporine	141-154	poly(ADP-ribose) polymerase 1	Homo sapiens	42-48
19216720-8	2009	Meanwhile, the use of 3-aminobenzamide, a PARP-1 inhibitor known to prevent AIF (apoptosis-inducing factor) release, significantly decreases staurosporine-induced death in these p53mt carcinoma cells, suggesting a preferential implication of caspase-independent apoptosis.	Staurosporine	141-154	apoptosis inducing factor mitochondria associated 1	Homo sapiens	76-79
19216720-8	2009	Meanwhile, the use of 3-aminobenzamide, a PARP-1 inhibitor known to prevent AIF (apoptosis-inducing factor) release, significantly decreases staurosporine-induced death in these p53mt carcinoma cells, suggesting a preferential implication of caspase-independent apoptosis.	Staurosporine	141-154	apoptosis inducing factor mitochondria associated 1	Homo sapiens	81-106
19635195-8	2009	Cell apoptosis was detected by FCM when cells were cultured for 48 h or cultured with staurosporine for 8 h. RESULTS: Caveolin-1 was overexpressed in Hs578T/Dox-cav-1 cells.	Staurosporine	86-99	caveolin 1	Homo sapiens	118-128
19635195-14	2009	Over-expressed Caveolin-1 significantly reduced apoptosis index when the cells were cultured for 48 h [(5.7+/-0.5)% vs. (11.3+/-0.8)%] or cultured with staurosporine for 8 h [(13.8+/-1.2)% vs (21.4+/-1.9)%].	Staurosporine	152-165	caveolin 1	Homo sapiens	15-25
19363095-4	2009	Treatment of wild-type seedlings with the protein kinase inhibitor staurosporine phenocopies the reduced auxin transport and gravity response of pid-9, while pid-9 is resistant to inhibition by staurosporine.	Staurosporine	67-80	Protein kinase superfamily protein	Arabidopsis thaliana	145-148
19168028-7	2009	Functional experiments showed that in order to be active ReP1-NCXSQ must become phosphorylated in the presence of MgATP by a kinase that is Staurosporin insensitive.	Staurosporine	140-152	CHM Rab escort protein	Homo sapiens	57-61
19567201-4	2009	Moreover, specific inhibitors, such as staurosporine, H89 and heparin, inhibited internalization of CCR9, which indicated a role of protein kinase C (PKC) and G protein-coupled kinase 2 (GRK2), respectively.	Staurosporine	39-52	C-C motif chemokine receptor 9	Homo sapiens	100-104
19567201-4	2009	Moreover, specific inhibitors, such as staurosporine, H89 and heparin, inhibited internalization of CCR9, which indicated a role of protein kinase C (PKC) and G protein-coupled kinase 2 (GRK2), respectively.	Staurosporine	39-52	proline rich transmembrane protein 2	Homo sapiens	132-148
19567201-4	2009	Moreover, specific inhibitors, such as staurosporine, H89 and heparin, inhibited internalization of CCR9, which indicated a role of protein kinase C (PKC) and G protein-coupled kinase 2 (GRK2), respectively.	Staurosporine	39-52	proline rich transmembrane protein 2	Homo sapiens	150-153
19567201-4	2009	Moreover, specific inhibitors, such as staurosporine, H89 and heparin, inhibited internalization of CCR9, which indicated a role of protein kinase C (PKC) and G protein-coupled kinase 2 (GRK2), respectively.	Staurosporine	39-52	G protein-coupled receptor kinase 2	Homo sapiens	159-185
19567201-4	2009	Moreover, specific inhibitors, such as staurosporine, H89 and heparin, inhibited internalization of CCR9, which indicated a role of protein kinase C (PKC) and G protein-coupled kinase 2 (GRK2), respectively.	Staurosporine	39-52	G protein-coupled receptor kinase 2	Homo sapiens	187-191
19363095-4	2009	Treatment of wild-type seedlings with the protein kinase inhibitor staurosporine phenocopies the reduced auxin transport and gravity response of pid-9, while pid-9 is resistant to inhibition by staurosporine.	Staurosporine	194-207	Protein kinase superfamily protein	Arabidopsis thaliana	158-161
19363095-6	2009	Gravity response defects of rcn1 and pid-9 are partially rescued by treatment with staurosporine and cantharidin, respectively.	Staurosporine	83-96	ARM repeat superfamily protein	Arabidopsis thaliana	28-32
19363095-6	2009	Gravity response defects of rcn1 and pid-9 are partially rescued by treatment with staurosporine and cantharidin, respectively.	Staurosporine	83-96	Protein kinase superfamily protein	Arabidopsis thaliana	37-40
19417139-8	2009	Interestingly, high expression of ET-1 was shown in Colo205-R cells and correlated with low sensitivity to PEP005 and staurosporine in a panel of 10 human cancer cell lines.	Staurosporine	118-131	endothelin 1	Homo sapiens	34-38
19466601-3	2009	In order to characterize the contribution of Hsp27 in blocking the two major apoptotic pathways operational within cells, we exposed H9c2 cells to staurosporine and cobalt chloride, agents that induce mitochondria-dependent (intrinsic) and -independent (extrinsic) pathways of apoptosis in cells respectively.	Staurosporine	147-160	heat shock protein family B (small) member 1	Rattus norvegicus	45-50
19211028-5	2009	Its inhibition of serum-starvation- or staurosporine-induced apoptosis was reflected by less apoptotic cells, reduced BAX expression and increased levels of Bcl-2 and Bcl-X.	Staurosporine	39-52	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
19211028-5	2009	Its inhibition of serum-starvation- or staurosporine-induced apoptosis was reflected by less apoptotic cells, reduced BAX expression and increased levels of Bcl-2 and Bcl-X.	Staurosporine	39-52	BCL2 apoptosis regulator	Homo sapiens	157-162
19211028-5	2009	Its inhibition of serum-starvation- or staurosporine-induced apoptosis was reflected by less apoptotic cells, reduced BAX expression and increased levels of Bcl-2 and Bcl-X.	Staurosporine	39-52	BCL2 like 1	Homo sapiens	167-172
19211028-6	2009	Annexin V staining and flow cytometry analysis showed reduced staurosporine-induced apoptosis in human myoblasts in response to HMB.	Staurosporine	62-75	annexin A5	Homo sapiens	0-9
19229559-6	2009	In lymphoblastoid cells carrying SCA8 large alleles, treatment of MG-132 or staurosporine significantly increases the cell death or caspase 3 activity.	Staurosporine	76-89	ataxin 8	Homo sapiens	33-37
19168126-3	2009	Here, we report that adenovirus-LETM1 increased the sensitivity of HeLa cells to apoptosis, induced by either staurosporine or actinomycin D.	Staurosporine	110-123	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	32-37
19229559-6	2009	In lymphoblastoid cells carrying SCA8 large alleles, treatment of MG-132 or staurosporine significantly increases the cell death or caspase 3 activity.	Staurosporine	76-89	caspase 3	Homo sapiens	132-141
19299916-2	2009	Here, we find that early and sustained increase in cytosolic ([Ca2(+)]c) and mitochondrial Ca2(+) levels ([Ca2(+)]m) is essential for the increased sensitivity to staurosporine- induced cell death following neuronal differentiation in PC12 cells.	Staurosporine	163-176	carbonic anhydrase 2	Rattus norvegicus	63-66
19214987-7	2009	Forced Cten expression did not cause change in cell numbers, although it did confer resistance to staurosporine-induced apoptosis (p &lt; 0.005).	Staurosporine	98-111	tensin 4	Homo sapiens	7-11
18846424-3	2009	In this report, we demonstrate that Staurosporine (STS) and Etoposide (ETS) induced apoptotic cell death of NSC by a mechanism requiring Caspase 3 activation, poly (ADP-ribose) polymerase and Lamin A/C cleavage.	Staurosporine	36-49	lamin A	Mus musculus	192-201
18846424-3	2009	In this report, we demonstrate that Staurosporine (STS) and Etoposide (ETS) induced apoptotic cell death of NSC by a mechanism requiring Caspase 3 activation, poly (ADP-ribose) polymerase and Lamin A/C cleavage.	Staurosporine	51-54	lamin A	Mus musculus	192-201
19299916-2	2009	Here, we find that early and sustained increase in cytosolic ([Ca2(+)]c) and mitochondrial Ca2(+) levels ([Ca2(+)]m) is essential for the increased sensitivity to staurosporine- induced cell death following neuronal differentiation in PC12 cells.	Staurosporine	163-176	carbonic anhydrase 2	Rattus norvegicus	91-94
19299916-2	2009	Here, we find that early and sustained increase in cytosolic ([Ca2(+)]c) and mitochondrial Ca2(+) levels ([Ca2(+)]m) is essential for the increased sensitivity to staurosporine- induced cell death following neuronal differentiation in PC12 cells.	Staurosporine	163-176	carbonic anhydrase 2	Rattus norvegicus	91-94
19299916-3	2009	Consistently, pretreatment of differentiated PC12 cells with the intracellular Ca2(+)-chelator EGTA-AM diminished staurosporine-induced PARP cleavage and cell death.	Staurosporine	114-127	carbonic anhydrase 2	Rattus norvegicus	79-82
19299916-4	2009	Furthermore, Ca2(+) overload and enhanced vulnerability to staurosporine in differentiated cells were prevented by Bcl-XL overexpression.	Staurosporine	59-72	Bcl2-like 1	Rattus norvegicus	115-121
19299916-5	2009	Our data reveal a new regulatory role for differentiation-dependent alteration of Ca2(+) signaling in cell death in response to staurosporine.	Staurosporine	128-141	carbonic anhydrase 2	Rattus norvegicus	82-85
19187443-7	2009	Interestingly, we also show that EC33 and pl302 lower staurosporine-stimulated activation of caspase-3 in wild-type fibroblasts but not in betaAPP/beta-amyloid precursor protein-like protein 2 (APLP2) double knockout fibroblasts, suggesting that protecting endogenous fl-Abeta physiological production triggers neuroprotective phenotype.	Staurosporine	54-67	caspase 3	Homo sapiens	93-102
19204004-5	2009	P2X(7) transfectants survived and even proliferated in serum-free conditions and were resistant to apoptosis triggered by ceramide, staurosporin, or intracellular Zn(2+) chelation.	Staurosporine	132-144	purinergic receptor P2X 7	Homo sapiens	0-6
19305421-4	2009	RESULTS: Adenosine inhibited the high DHO-affinity pump current (I(h)) in a concentration-dependent manner, which was blocked by the selective adenosine A(1) receptor antagonist DPCPX and the general protein kinase C (PKC) antagonists staurosporine, GF 109203X or the specific delta isoform antagonist rottlerin.	Staurosporine	235-248	adenosine receptor A1	Cavia porcellus	143-166
19159427-6	2009	The adhesin could also induce interleukin-8 secretion from INT-407 cells, which was inhibited in the presence of dantrolene as well as staurosporin (inhibitor of PKC).	Staurosporine	135-147	C-X-C motif chemokine ligand 8	Homo sapiens	30-43
19187441-3	2009	Here we show that over-expression of NCT increases the viability of human embryonic kidney (HEK293) cells and decreases staurosporine (STS)- and thapsigargin (TPS)-induced caspase-3 activation in various cell lines from human and neuronal origins by Akt-dependent pathway.	Staurosporine	120-133	nicastrin	Homo sapiens	37-40
19187443-7	2009	Interestingly, we also show that EC33 and pl302 lower staurosporine-stimulated activation of caspase-3 in wild-type fibroblasts but not in betaAPP/beta-amyloid precursor protein-like protein 2 (APLP2) double knockout fibroblasts, suggesting that protecting endogenous fl-Abeta physiological production triggers neuroprotective phenotype.	Staurosporine	54-67	amyloid beta precursor protein	Homo sapiens	271-276
19187441-3	2009	Here we show that over-expression of NCT increases the viability of human embryonic kidney (HEK293) cells and decreases staurosporine (STS)- and thapsigargin (TPS)-induced caspase-3 activation in various cell lines from human and neuronal origins by Akt-dependent pathway.	Staurosporine	135-138	nicastrin	Homo sapiens	37-40
19002711-5	2009	However, activation of CFTR was suppressed by inhibition of phospholipase C and by the nonselective protein kinase inhibitor staurosporine.	Staurosporine	125-138	CF transmembrane conductance regulator	Homo sapiens	23-27
18787932-0	2009	Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.	Staurosporine	64-77	cyclin A1	Homo sapiens	35-44
19135127-3	2009	Cadmium-induced activation of caspase-3 was significantly attenuated in HEK-sbGHS-R1a cells compared to wild-type HEK293 cells, while the apoptotic responses to the protein kinase C inhibitor staurosporine were similar.	Staurosporine	192-205	caspase 3	Homo sapiens	30-39
19103604-8	2009	Moreover, knockdown of hNOA1 renders cells more resistant to apoptotic stimuli such as gamma-interferon and staurosporine, supporting a role for hNOA1 in regulating apoptosis.	Staurosporine	108-121	nitric oxide associated 1	Homo sapiens	23-28
19217411-4	2009	Using genetic, biochemical, pharmacological, and functional approaches, we here show that ceramide and staurosporine target PP2A and protein kinases A and C, respectively, in a mitochondria-associated signaling complex to induce dephosphorylation of the BH3-only protein Bad.	Staurosporine	103-116	protein phosphatase 2 phosphatase activator	Homo sapiens	124-128
19204869-3	2009	The present report shows that silencing of IDPc expression in HeLa cells greatly enhances apoptosis induced by staurosporine.	Staurosporine	111-124	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	43-47
19204869-4	2009	Transfection of HeLa cells with an IDPc small interfering RNA (siRNA) markedly decreased activity of IDPc, enhancing the susceptibility of staurosporine-induced apoptosis reflected by DNA fragmentation, cellular redox status and the modulation of apoptotic marker proteins.	Staurosporine	139-152	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	35-39
19204869-5	2009	These results indicate that IDPc may play an important role in regulating the apoptosis induced by staurosporine and the sensitizing effect of IDPc siRNA on the apoptotic cell death of HeLa cells offers the possibility of developing a modifier of cancer chemotherapy.	Staurosporine	99-112	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
19253104-5	2009	FSH, protein kinase A activator (Bu)(2)cAMP, prostaglandin E(2) (PGE(2)), activin A and the broad protein kinase regulator staurosporine decreased ADM mRNA accumulation in cultured granulosa-luteal cells time- and dose-dependently.	Staurosporine	123-136	adrenomedullin	Homo sapiens	147-150
19027715-7	2009	Several small molecules sharing a basic indolocarbazole structure (Go6976, K-252a, and staurosporine) where identified as potent inhibitors of LRRK2 kinase activity.	Staurosporine	87-100	leucine rich repeat kinase 2	Homo sapiens	143-148
18983973-0	2009	E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression.	Staurosporine	62-75	BCL2 apoptosis regulator	Homo sapiens	93-98
18983973-3	2009	In this study, we found that E-cadherin positive breast cell lines were less sensitive to staurosporine compared to E-cadherin negative ones.	Staurosporine	90-103	cadherin 1	Homo sapiens	29-39
18983973-4	2009	Next, we substantiated that the expression of E-cadherin in MDA-MB-435 cells could partly counteract the cytotoxic effect induced by staurosporine through a series of apoptosis assay.	Staurosporine	133-146	cadherin 1	Homo sapiens	46-56
18983973-5	2009	The resistance of E-cadherin over-expressing cells to staurosporine may due to the up-regulation of Bcl-2/Bax ratio.	Staurosporine	54-67	cadherin 1	Homo sapiens	18-28
18983973-5	2009	The resistance of E-cadherin over-expressing cells to staurosporine may due to the up-regulation of Bcl-2/Bax ratio.	Staurosporine	54-67	BCL2 apoptosis regulator	Homo sapiens	100-105
18983973-5	2009	The resistance of E-cadherin over-expressing cells to staurosporine may due to the up-regulation of Bcl-2/Bax ratio.	Staurosporine	54-67	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
18983973-8	2009	All these results demonstrated the chemo-resistance function of E-cadherin in the condition of staurosporine treatment, therefore, might contribute effective therapeutic strategies in breast carcinoma.	Staurosporine	95-108	cadherin 1	Homo sapiens	64-74
19302552-5	2009	2 Staurosporine (IC(50) approximately 0.8 nm) (a general protein kinase inhibitor) and bis-indolyl-maleimide I (IC(50) approximately 200 nm) (a selective protein kinase C inhibitor) inhibited PD98059-induced alpha(1B)-adrenoceptor phosphorylation.	Staurosporine	2-15	adrenoceptor alpha 1B	Homo sapiens	208-230
18840413-7	2009	STP-induced HT29 cell apoptosis was associated with caspase-3 activation independent of caspase-8 or caspase-9 activity; accordingly, inhibitors of the latter caspases were without effect on STP-induced apoptosis.	Staurosporine	0-3	caspase 3	Homo sapiens	52-61
18840413-8	2009	STP similarly induced GSH efflux and apoptosis in a non-malignant human NCM460 colonic cell line in association with caspase-3 activation.	Staurosporine	0-3	caspase 3	Homo sapiens	117-126
19255500-7	2009	U73122 (PLC inhibitor), staurosporine (PKC inhibitor), LY294002 (PI3K inhibitor), and Akt inhibitor blocked the phosphorylation of p44/42 MAPKs.	Staurosporine	24-37	mitogen-activated protein kinase 3	Mus musculus	131-134
19255500-9	2009	LA-induced increases in the cell cycle regulatory proteins, cyclin D1, cyclin E, cyclin-dependent kinase (CDK) 2, and CDK 4, were blocked by U73122, staurosporine, LY294002, Akt inhibitor, PD98059, and metformin (gluconeogenesis inhibitor).	Staurosporine	149-162	cyclin D1	Mus musculus	60-69
19255500-9	2009	LA-induced increases in the cell cycle regulatory proteins, cyclin D1, cyclin E, cyclin-dependent kinase (CDK) 2, and CDK 4, were blocked by U73122, staurosporine, LY294002, Akt inhibitor, PD98059, and metformin (gluconeogenesis inhibitor).	Staurosporine	149-162	cyclin-dependent kinase 2	Mus musculus	81-112
19255500-9	2009	LA-induced increases in the cell cycle regulatory proteins, cyclin D1, cyclin E, cyclin-dependent kinase (CDK) 2, and CDK 4, were blocked by U73122, staurosporine, LY294002, Akt inhibitor, PD98059, and metformin (gluconeogenesis inhibitor).	Staurosporine	149-162	thymoma viral proto-oncogene 1	Mus musculus	174-177
18633436-6	2009	Of various agents tested in HaCaT cell cultures, only retinoic acid (10(-6) M) and staurosporine (2.5 x 10(-8) M) upregulated MMP-21 mRNA and protein expression, whereas tumor promoters, hormones, or dexamethasone were without effect.	Staurosporine	83-96	matrix metallopeptidase 21	Homo sapiens	126-132
18787932-7	2009	Interestingly, ubiquitination- and proteasomal-mediated degradation of cyclin A1 is prevented in cells treated with staurosporine or TNFalpha.	Staurosporine	116-129	cyclin A1	Homo sapiens	71-80
18787932-8	2009	Induction of apoptosis in U-937 cells by staurosporine or TNFalpha resulted in an increase in cyclin A1 protein expression, which correlated well with cyclin A1 protein modification and the activation of caspase-3.	Staurosporine	41-54	cyclin A1	Homo sapiens	94-103
18787932-8	2009	Induction of apoptosis in U-937 cells by staurosporine or TNFalpha resulted in an increase in cyclin A1 protein expression, which correlated well with cyclin A1 protein modification and the activation of caspase-3.	Staurosporine	41-54	cyclin A1	Homo sapiens	151-160
18787932-8	2009	Induction of apoptosis in U-937 cells by staurosporine or TNFalpha resulted in an increase in cyclin A1 protein expression, which correlated well with cyclin A1 protein modification and the activation of caspase-3.	Staurosporine	41-54	caspase 3	Homo sapiens	204-213
18787932-10	2009	We further propose that CDC25C may be associated with cyclin A1 protein modification in response to staurosporine or TNFalpha treatment.	Staurosporine	100-113	cell division cycle 25C	Homo sapiens	24-30
18787932-10	2009	We further propose that CDC25C may be associated with cyclin A1 protein modification in response to staurosporine or TNFalpha treatment.	Staurosporine	100-113	cyclin A1	Homo sapiens	54-63
18787932-11	2009	Our results suggest that cyclin A1 protein is stabilized via post-transcriptional modification in response to apoptosis induced by staurosporine or TNFalpha.	Staurosporine	131-144	cyclin A1	Homo sapiens	25-34
19216720-8	2009	Meanwhile, the use of 3-aminobenzamide, a PARP-1 inhibitor known to prevent AIF (apoptosis-inducing factor) release, significantly decreases staurosporine-induced death in these p53mt carcinoma cells, suggesting a preferential implication of caspase-independent apoptosis.	Staurosporine	141-154	tumor protein p53	Homo sapiens	178-181
19216720-9	2009	On the other hand, we show that p53, whose activity is modulated by pifithrin-alpha, isolated as a suppressor of p53-mediated transactivation, or by PRIMA-1 (p53 reactivation and induction of massive apoptosis), that reactivates mutant p53, causes cytochrome c release as well as mitochondrio-nuclear AIF translocation in staurosporine-induced apoptosis of cervical carcinoma cells.	Staurosporine	322-335	tumor protein p53	Homo sapiens	32-35
19216720-9	2009	On the other hand, we show that p53, whose activity is modulated by pifithrin-alpha, isolated as a suppressor of p53-mediated transactivation, or by PRIMA-1 (p53 reactivation and induction of massive apoptosis), that reactivates mutant p53, causes cytochrome c release as well as mitochondrio-nuclear AIF translocation in staurosporine-induced apoptosis of cervical carcinoma cells.	Staurosporine	322-335	proline rich membrane anchor 1	Homo sapiens	149-156
19216720-10	2009	CONCLUSIONS: The present paper highlights that staurosporine engages the intrinsic mitochondrial apoptotic pathway via caspase-8 or caspase-9 signalling cascades and via caspase-independent cell death, as well as through p53 activity.	Staurosporine	47-60	caspase 8	Homo sapiens	119-128
19216720-10	2009	CONCLUSIONS: The present paper highlights that staurosporine engages the intrinsic mitochondrial apoptotic pathway via caspase-8 or caspase-9 signalling cascades and via caspase-independent cell death, as well as through p53 activity.	Staurosporine	47-60	caspase 9	Homo sapiens	132-141
19216720-10	2009	CONCLUSIONS: The present paper highlights that staurosporine engages the intrinsic mitochondrial apoptotic pathway via caspase-8 or caspase-9 signalling cascades and via caspase-independent cell death, as well as through p53 activity.	Staurosporine	47-60	tumor protein p53	Homo sapiens	221-224
19261878-7	2009	Moreover, HDACIs also prevented caspase-3 cleavage in postnatal cortical neurons treated with staurosporine, 3-nitropropionic acid and a Bcl-2 inhibitor, all of which require the presence of Bax but not p53 to promote apoptosis.	Staurosporine	94-107	caspase 3	Homo sapiens	32-41
19261878-7	2009	Moreover, HDACIs also prevented caspase-3 cleavage in postnatal cortical neurons treated with staurosporine, 3-nitropropionic acid and a Bcl-2 inhibitor, all of which require the presence of Bax but not p53 to promote apoptosis.	Staurosporine	94-107	BCL2 associated X, apoptosis regulator	Homo sapiens	191-194
18339380-10	2009	PARP proteins (75 kDa, 63 kDa, and 60 kDa) were evaluated after inducing apoptosis by hydrogen peroxide and staurosporine exposure.	Staurosporine	108-121	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
18339380-11	2009	CONCLUSION(S): PARP-2 may have a role in prevention of oxygen species/oxidative stress and chemical (staurosporine)-induced sperm cell apoptosis.	Staurosporine	101-114	poly(ADP-ribose) polymerase 2	Homo sapiens	15-21
19006119-7	2009	IL-6-induced increase of 2-DG uptake and GLUT-2 protein expression were blocked by JAK2-specific siRNA, a STAT3 inhibitor, staurosporine, and bisindolylmaleimide I (PKC inhibitors).	Staurosporine	123-136	interleukin 6	Gallus gallus	0-4
19006119-7	2009	IL-6-induced increase of 2-DG uptake and GLUT-2 protein expression were blocked by JAK2-specific siRNA, a STAT3 inhibitor, staurosporine, and bisindolylmaleimide I (PKC inhibitors).	Staurosporine	123-136	solute carrier family 2 member 2	Gallus gallus	41-47
19101580-8	2009	In addition, we demonstrate that, like LiCl or VPA treatment, Six1 over-expression protects SH-SY5Y cells from staurosporine-induced apoptosis via the blockade of caspsase-3 activation, whereas removal of Six1 protein via siRNA antagonises the ability of LiCl and VPA to protect SH-SY5Y cells from STS-induced apoptosis.	Staurosporine	111-124	SIX homeobox 1	Homo sapiens	62-66
19203395-4	2009	In the absence of doxycycline, the stable ATXN8OS CR cell lines exhibit low levels of ATXN8OS expression and a repeat length-related increase in staurosporine sensitivity and in the number of annexin positive cells.	Staurosporine	145-158	ATXN8 opposite strand lncRNA	Homo sapiens	42-49
19049977-5	2009	Moreover, expression of the VDAC1-based peptides in cells overexpressing HK-I or HK-II prevented HK-mediated protection against staurosporine-induced release of cytochrome c and subsequent cell death.	Staurosporine	128-141	voltage dependent anion channel 1	Homo sapiens	28-33
19049977-5	2009	Moreover, expression of the VDAC1-based peptides in cells overexpressing HK-I or HK-II prevented HK-mediated protection against staurosporine-induced release of cytochrome c and subsequent cell death.	Staurosporine	128-141	hexokinase 1	Homo sapiens	73-77
19049977-5	2009	Moreover, expression of the VDAC1-based peptides in cells overexpressing HK-I or HK-II prevented HK-mediated protection against staurosporine-induced release of cytochrome c and subsequent cell death.	Staurosporine	128-141	hexokinase 2	Homo sapiens	81-86
19049977-5	2009	Moreover, expression of the VDAC1-based peptides in cells overexpressing HK-I or HK-II prevented HK-mediated protection against staurosporine-induced release of cytochrome c and subsequent cell death.	Staurosporine	128-141	cytochrome c, somatic	Homo sapiens	161-173
19088254-6	2009	ANG II-induced inhibition of hOAT1 activity could be prevented by treating hOAT1-expressing cells with staurosporine, a general protein kinase C (PKC) inhibitor.	Staurosporine	103-116	angiogenin	Homo sapiens	0-3
19088254-6	2009	ANG II-induced inhibition of hOAT1 activity could be prevented by treating hOAT1-expressing cells with staurosporine, a general protein kinase C (PKC) inhibitor.	Staurosporine	103-116	solute carrier family 22 member 6	Homo sapiens	29-34
19088254-6	2009	ANG II-induced inhibition of hOAT1 activity could be prevented by treating hOAT1-expressing cells with staurosporine, a general protein kinase C (PKC) inhibitor.	Staurosporine	103-116	solute carrier family 22 member 6	Homo sapiens	75-80
19088254-6	2009	ANG II-induced inhibition of hOAT1 activity could be prevented by treating hOAT1-expressing cells with staurosporine, a general protein kinase C (PKC) inhibitor.	Staurosporine	103-116	protein kinase C alpha	Homo sapiens	146-149
18983913-4	2009	Treatment with the cytokine efficaciously protected mesoangioblasts from apoptosis induced by serum starvation or staurosporine treatment assessed by various means such as activation of caspase-3, determination of cytoplasmic histone-associated-DNA-fragments and PE-AnnexinV staining.	Staurosporine	114-127	caspase 3	Homo sapiens	186-195
18983913-5	2009	The protective action of TGFbeta from staurosporine-induced apoptosis was strongly reduced when the SphK activity was inhibited by drugs, when SphK1 but not SphK2 was downregulated by specific siRNA and when a SphK1 dominant negative mutant was overexpressed.	Staurosporine	38-51	transforming growth factor beta 1	Homo sapiens	25-32
18983913-5	2009	The protective action of TGFbeta from staurosporine-induced apoptosis was strongly reduced when the SphK activity was inhibited by drugs, when SphK1 but not SphK2 was downregulated by specific siRNA and when a SphK1 dominant negative mutant was overexpressed.	Staurosporine	38-51	sphingosine kinase 1	Homo sapiens	100-104
18983913-5	2009	The protective action of TGFbeta from staurosporine-induced apoptosis was strongly reduced when the SphK activity was inhibited by drugs, when SphK1 but not SphK2 was downregulated by specific siRNA and when a SphK1 dominant negative mutant was overexpressed.	Staurosporine	38-51	sphingosine kinase 1	Homo sapiens	143-148
18983913-5	2009	The protective action of TGFbeta from staurosporine-induced apoptosis was strongly reduced when the SphK activity was inhibited by drugs, when SphK1 but not SphK2 was downregulated by specific siRNA and when a SphK1 dominant negative mutant was overexpressed.	Staurosporine	38-51	sphingosine kinase 1	Homo sapiens	210-215
18983913-6	2009	Staurosporine treatment induced down-regulation of both SphK isoforms and TGFbeta rescued SphK1 but not SphK2 expression.	Staurosporine	0-13	sphingosine kinase 1	Homo sapiens	56-60
18983913-6	2009	Staurosporine treatment induced down-regulation of both SphK isoforms and TGFbeta rescued SphK1 but not SphK2 expression.	Staurosporine	0-13	transforming growth factor beta 1	Homo sapiens	74-81
18983913-6	2009	Staurosporine treatment induced down-regulation of both SphK isoforms and TGFbeta rescued SphK1 but not SphK2 expression.	Staurosporine	0-13	sphingosine kinase 1	Homo sapiens	90-95
18983913-7	2009	Interestingly, TGFbeta strongly enhanced SphK activity during staurosporine-induced cell death.	Staurosporine	62-75	transforming growth factor beta 1	Homo sapiens	15-22
18983913-7	2009	Interestingly, TGFbeta strongly enhanced SphK activity during staurosporine-induced cell death.	Staurosporine	62-75	sphingosine kinase 1	Homo sapiens	41-45
18832097-4	2009	In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished [(3)H]1,25-dihydroxy vitamin D(3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis.	Staurosporine	93-106	caspase 3	Homo sapiens	67-76
18832097-4	2009	In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished [(3)H]1,25-dihydroxy vitamin D(3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis.	Staurosporine	93-106	vitamin D receptor	Homo sapiens	202-205
18832097-4	2009	In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished [(3)H]1,25-dihydroxy vitamin D(3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis.	Staurosporine	108-111	caspase 3	Homo sapiens	67-76
18832097-4	2009	In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished [(3)H]1,25-dihydroxy vitamin D(3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis.	Staurosporine	108-111	vitamin D receptor	Homo sapiens	169-172
18832097-4	2009	In the LNCaP prostate cancer cell line, induction of apoptosis and caspase-3/7 activities by staurosporine (STS) abolished [(3)H]1,25-dihydroxy vitamin D(3) binding and VDR protein, suggesting that the VDR may be targeted for inactivation by caspases during apoptosis.	Staurosporine	108-111	vitamin D receptor	Homo sapiens	202-205
19046404-6	2009	In the presence of additional apoptotic challenges (staurosporine, etoposide, and hydrogen peroxide), cells bearing mSOD1 inclusions were susceptible to further apoptosis suggesting they were in a pro-apoptotic state, thus confirming that inclusions are linked to toxicity.	Staurosporine	52-65	superoxide dismutase 1, soluble	Mus musculus	116-121
19038795-8	2009	Next, we demonstrated that conditioned medium from SD-MSCs decreased staurosporin-induced cell death in the KHOS osteosarcoma cell line, and that this effect was partially reversed by immunodepletion of IGF1 or leptin from the conditioned medium.	Staurosporine	69-81	insulin like growth factor 1	Homo sapiens	203-207
19137075-2	2009	METHODS: Transformed RGC-5 cells were treated with 2.0 microM staurosporine (SS), a broad-spectrum protein kinase-C inhibitor, to induce growth arrest, differentiation, and elevated levels of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA).	Staurosporine	62-75	plasminogen activator, tissue	Mus musculus	192-220
19137075-2	2009	METHODS: Transformed RGC-5 cells were treated with 2.0 microM staurosporine (SS), a broad-spectrum protein kinase-C inhibitor, to induce growth arrest, differentiation, and elevated levels of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA).	Staurosporine	62-75	plasminogen activator, tissue	Mus musculus	222-225
19137075-2	2009	METHODS: Transformed RGC-5 cells were treated with 2.0 microM staurosporine (SS), a broad-spectrum protein kinase-C inhibitor, to induce growth arrest, differentiation, and elevated levels of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA).	Staurosporine	77-79	plasminogen activator, tissue	Mus musculus	192-220
19137075-2	2009	METHODS: Transformed RGC-5 cells were treated with 2.0 microM staurosporine (SS), a broad-spectrum protein kinase-C inhibitor, to induce growth arrest, differentiation, and elevated levels of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA).	Staurosporine	77-79	plasminogen activator, tissue	Mus musculus	222-225
19137075-2	2009	METHODS: Transformed RGC-5 cells were treated with 2.0 microM staurosporine (SS), a broad-spectrum protein kinase-C inhibitor, to induce growth arrest, differentiation, and elevated levels of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA).	Staurosporine	77-79	plasminogen activator, urokinase	Mus musculus	231-262
19137075-2	2009	METHODS: Transformed RGC-5 cells were treated with 2.0 microM staurosporine (SS), a broad-spectrum protein kinase-C inhibitor, to induce growth arrest, differentiation, and elevated levels of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA).	Staurosporine	77-79	plasminogen activator, urokinase	Mus musculus	264-267
19137075-7	2009	RESULTS: Compared to RGC-5 cells left untreated, cells treated with either SS alone or SS and norrin secreted elevated levels of tPA and uPA.	Staurosporine	75-77	plasminogen activator, tissue	Mus musculus	129-132
19137075-7	2009	RESULTS: Compared to RGC-5 cells left untreated, cells treated with either SS alone or SS and norrin secreted elevated levels of tPA and uPA.	Staurosporine	75-77	plasminogen activator, urokinase	Mus musculus	137-140
19137075-7	2009	RESULTS: Compared to RGC-5 cells left untreated, cells treated with either SS alone or SS and norrin secreted elevated levels of tPA and uPA.	Staurosporine	87-89	plasminogen activator, tissue	Mus musculus	129-132
19137075-7	2009	RESULTS: Compared to RGC-5 cells left untreated, cells treated with either SS alone or SS and norrin secreted elevated levels of tPA and uPA.	Staurosporine	87-89	plasminogen activator, urokinase	Mus musculus	137-140
19563063-3	2009	Cisplatin resistant ovarian cancer cell line SKOV3/DDP cells were treated by staurosporine (a kind of PKC inhibitors).	Staurosporine	77-90	proline rich transmembrane protein 2	Homo sapiens	102-105
18983973-0	2009	E-cadherin decreased human breast cancer cells sensitivity to staurosporine by up-regulating Bcl-2 expression.	Staurosporine	62-75	cadherin 1	Homo sapiens	0-10
18716132-5	2008	Pretreatment of these cells with the PTK inhibitor staurosporine led to sustained STAT6 phosphorylation consistent with STAT6 serving as a direct substrate of PTP1B.	Staurosporine	51-64	protein tyrosine kinase 2 beta	Homo sapiens	37-40
18716132-5	2008	Pretreatment of these cells with the PTK inhibitor staurosporine led to sustained STAT6 phosphorylation consistent with STAT6 serving as a direct substrate of PTP1B.	Staurosporine	51-64	signal transducer and activator of transcription 6	Homo sapiens	82-87
18716132-5	2008	Pretreatment of these cells with the PTK inhibitor staurosporine led to sustained STAT6 phosphorylation consistent with STAT6 serving as a direct substrate of PTP1B.	Staurosporine	51-64	signal transducer and activator of transcription 6	Homo sapiens	120-125
18716132-5	2008	Pretreatment of these cells with the PTK inhibitor staurosporine led to sustained STAT6 phosphorylation consistent with STAT6 serving as a direct substrate of PTP1B.	Staurosporine	51-64	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	159-164
19352495-4	2009	METHODOLOGY/PRINCIPAL FINDINGS: Staurosporine (STS) was used as a tool to test for caspase involvement in BAG3 degradation.	Staurosporine	32-45	BAG cochaperone 3	Homo sapiens	106-110
19352495-4	2009	METHODOLOGY/PRINCIPAL FINDINGS: Staurosporine (STS) was used as a tool to test for caspase involvement in BAG3 degradation.	Staurosporine	47-50	BAG cochaperone 3	Homo sapiens	106-110
19563063-18	2009	Phosphorylation of Cx43 caused by PKC can be inhibited by staurosporine.	Staurosporine	58-71	proline rich transmembrane protein 2	Homo sapiens	34-37
18948074-4	2008	We found that the general kinase inhibitor staurosporine induces mafA expression without altering the stability of the protein.	Staurosporine	43-56	MAF bZIP transcription factor A	Homo sapiens	65-69
18948074-5	2008	Inhibition of the MAP-kinase JNK mimics the effects of staurosporine on the expression of mafA.	Staurosporine	55-68	mitogen-activated protein kinase 8	Homo sapiens	29-32
18948074-5	2008	Inhibition of the MAP-kinase JNK mimics the effects of staurosporine on the expression of mafA.	Staurosporine	55-68	MAF bZIP transcription factor A	Homo sapiens	90-94
18948074-7	2008	However, staurosporine, JNK, and calmodulin kinase have different effects on the induction of insulin expression.	Staurosporine	9-22	insulin	Homo sapiens	94-101
18977146-1	2008	The interaction energy was calculated, by the ab initio FMO method, for complexes between LCK protein and four inhibitors (staurosporine, BMS compound 2, and our compounds 3 and 4).	Staurosporine	123-136	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	90-93
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	Staurosporine	181-194	kininogen 1	Homo sapiens	17-19
18948121-6	2008	Furthermore, the BK-induced increase in COX-2 expression was blocked by the PI-3 kinase inhibitors wortmannin and LY294002, Akt inhibitor, and the protein kinase C (PKC) inhibitors staurosporine and bisindolylmaleimide I, suggesting the role of PI-3 kinase and PKC in this process.	Staurosporine	181-194	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	40-45
19563063-11	2009	(2) Immunohistochemically, PKC was down regulated, and Cx43 and non-phosphorylated Cx43 were up regulated in SKOV3/DDP cells after staurosporine treatment.	Staurosporine	131-144	proline rich transmembrane protein 2	Homo sapiens	27-30
19563063-11	2009	(2) Immunohistochemically, PKC was down regulated, and Cx43 and non-phosphorylated Cx43 were up regulated in SKOV3/DDP cells after staurosporine treatment.	Staurosporine	131-144	gap junction protein alpha 1	Homo sapiens	55-59
19563063-11	2009	(2) Immunohistochemically, PKC was down regulated, and Cx43 and non-phosphorylated Cx43 were up regulated in SKOV3/DDP cells after staurosporine treatment.	Staurosporine	131-144	gap junction protein alpha 1	Homo sapiens	83-87
19563063-12	2009	The longer the staurosporine worked, the more expression of Cx43 was.	Staurosporine	15-28	gap junction protein alpha 1	Homo sapiens	60-64
19563063-18	2009	Phosphorylation of Cx43 caused by PKC can be inhibited by staurosporine.	Staurosporine	58-71	gap junction protein alpha 1	Homo sapiens	19-23
18752579-4	2008	RESULTS: Several PKC inhibitors (staurosporine, Ro31-8220, myristoylated PKC peptide inhibitor and Go6983) block VEGF-induced but not histamine-induced VWF secretion.	Staurosporine	33-46	vascular endothelial growth factor A	Homo sapiens	113-117
18621151-8	2008	Protein kinase C inhibitors (Ro 31-8220, calphostin C, staurosporine, and chelerythrine chloride) also inhibited LPS-induced c-fos transcription.	Staurosporine	55-68	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	125-130
18783337-3	2008	Wild-type mesangial cells responded to staurosporine with increased DNA fragmentation and caspase-3 processing, which was enhanced in SK-1(-/-) cells.	Staurosporine	39-52	caspase 3	Mus musculus	90-99
18783337-3	2008	Wild-type mesangial cells responded to staurosporine with increased DNA fragmentation and caspase-3 processing, which was enhanced in SK-1(-/-) cells.	Staurosporine	39-52	sphingosine kinase 1	Mus musculus	134-138
18783337-4	2008	In contrast, SK-2(-/-) cells were highly resistant to staurosporine-induced apoptosis.	Staurosporine	54-67	sphingosine kinase 2	Mus musculus	13-17
18783337-6	2008	Upon staurosporine treatment, phosphorylation of PKB and Bad decreased in wild-type and SK-1(-/-) cells, but remained high in SK-2(-/-) cells.	Staurosporine	5-18	sphingosine kinase 1	Mus musculus	88-92
18783337-6	2008	Upon staurosporine treatment, phosphorylation of PKB and Bad decreased in wild-type and SK-1(-/-) cells, but remained high in SK-2(-/-) cells.	Staurosporine	5-18	sphingosine kinase 2	Mus musculus	126-130
18755691-7	2008	Furthermore, stress conditions (exposure to staurosporine and hypoxia induced by sodium azide) caused significant increase in ATF3 expression and induced apoptosis, whereas knockdown of KLF6 by small interference RNA blocked the increase of ATF3 as well as the induction of apoptosis in these conditions.	Staurosporine	44-57	activating transcription factor 3	Homo sapiens	126-130
18755691-7	2008	Furthermore, stress conditions (exposure to staurosporine and hypoxia induced by sodium azide) caused significant increase in ATF3 expression and induced apoptosis, whereas knockdown of KLF6 by small interference RNA blocked the increase of ATF3 as well as the induction of apoptosis in these conditions.	Staurosporine	44-57	Kruppel like factor 6	Homo sapiens	186-190
18755691-7	2008	Furthermore, stress conditions (exposure to staurosporine and hypoxia induced by sodium azide) caused significant increase in ATF3 expression and induced apoptosis, whereas knockdown of KLF6 by small interference RNA blocked the increase of ATF3 as well as the induction of apoptosis in these conditions.	Staurosporine	44-57	activating transcription factor 3	Homo sapiens	241-245
18678869-9	2008	PAR2 effects are mediated in part by a phospholipase C/protein kinase C/ERK1,2 cascade, which increases Na,K-ATPase maximal activity and the paracellular sodium permeability, and by a different phospholipase C-dependent, staurosporine-sensitive cascade that controls the sodium affinity of Na,K-ATPase.	Staurosporine	221-234	F2R like trypsin receptor 1	Rattus norvegicus	0-4
18678869-9	2008	PAR2 effects are mediated in part by a phospholipase C/protein kinase C/ERK1,2 cascade, which increases Na,K-ATPase maximal activity and the paracellular sodium permeability, and by a different phospholipase C-dependent, staurosporine-sensitive cascade that controls the sodium affinity of Na,K-ATPase.	Staurosporine	221-234	mitogen activated protein kinase 3	Rattus norvegicus	72-78
18621020-3	2008	MRP1-overexpressing cells had lower intracellular GSH levels and higher levels of GSH release, under both basal conditions and after apoptosis was induced with either Fas antibody or staurosporine.	Staurosporine	183-196	ATP binding cassette subfamily C member 1	Homo sapiens	0-4
18503554-6	2008	The heat-induced MMP-1 expression was suppressed by Go6976 [calcium-dependent inhibitor] and staurosporine (ST, broad-spectrum PKC inhibitor), while rottlerin (ROT, calcium-independent PKCdelta inhibitor) had no effect.	Staurosporine	93-106	matrix metallopeptidase 1	Homo sapiens	17-22
18583398-10	2008	Rat and human hepatocellular Mrp2 were phosphorylated by phorbol ester pretreatment and recombinant cPKC alpha, nPKC epsilon, and PKA, respectively, in a staurosporine-sensitive manner.	Staurosporine	154-167	ATP binding cassette subfamily C member 2	Homo sapiens	29-33
18583398-10	2008	Rat and human hepatocellular Mrp2 were phosphorylated by phorbol ester pretreatment and recombinant cPKC alpha, nPKC epsilon, and PKA, respectively, in a staurosporine-sensitive manner.	Staurosporine	154-167	protein kinase C epsilon	Homo sapiens	112-124
18583398-10	2008	Rat and human hepatocellular Mrp2 were phosphorylated by phorbol ester pretreatment and recombinant cPKC alpha, nPKC epsilon, and PKA, respectively, in a staurosporine-sensitive manner.	Staurosporine	154-167	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	130-133
18550533-6	2008	The cleavage of Chk1 was similarly observed in human Jurkat cells treated with a non-genotoxic apoptosis inducer, staurosporine.	Staurosporine	114-127	checkpoint kinase 1	Homo sapiens	16-20
18653772-8	2008	Staurosporine induced robust activation of caspase-3 and nucleosomal DNA fragmentation, suggesting that the machinery of apoptosis is intact in HCN cells despite the apparent absence of apoptosis following insulin withdrawal.	Staurosporine	0-13	caspase 3	Rattus norvegicus	43-52
18566751-5	2008	Interestingly, the expression of TNF-alpha and COX-2 was significantly blocked by treatment with PKC inhibitor (Staurosporine) as well as ERK1/2 inhibitors (PD98059).	Staurosporine	112-125	tumor necrosis factor	Mus musculus	33-42
18566751-5	2008	Interestingly, the expression of TNF-alpha and COX-2 was significantly blocked by treatment with PKC inhibitor (Staurosporine) as well as ERK1/2 inhibitors (PD98059).	Staurosporine	112-125	cytochrome c oxidase II, mitochondrial	Mus musculus	47-52
18594935-5	2008	However, upon treatment with staurosporine, BRAt cells showed increased levels of active caspase-3 and increased cleavage of caspase-3 substrates, PARP and DFF45.	Staurosporine	29-42	caspase 3	Homo sapiens	89-98
18215418-8	2008	Rather Bcl-2 itself caused a significant amount of spontaneous cell death, and sensitised the cells to apoptotic agents such as staurosporine or ceramide.	Staurosporine	128-141	BCL2 apoptosis regulator	Homo sapiens	7-12
18634762-3	2008	In vitro, this antibody labeled the predicted 25 kDa caspase-cleavage fragment of TDP-43 without labeling full-length TDP-43 following digestion of recombinant TDP-43 with caspase-3 or treatment of HeLa cells with staurosporine.	Staurosporine	214-227	TAR DNA binding protein	Homo sapiens	82-88
18853744-0	2008	Degradation of plectin with modulation of cytokeratin 18 in human liver cells during staurosporine-induced apoptosis.	Staurosporine	85-98	plectin	Homo sapiens	15-22
18594935-5	2008	However, upon treatment with staurosporine, BRAt cells showed increased levels of active caspase-3 and increased cleavage of caspase-3 substrates, PARP and DFF45.	Staurosporine	29-42	caspase 3	Homo sapiens	125-134
18853744-0	2008	Degradation of plectin with modulation of cytokeratin 18 in human liver cells during staurosporine-induced apoptosis.	Staurosporine	85-98	keratin 18	Homo sapiens	42-56
18594935-5	2008	However, upon treatment with staurosporine, BRAt cells showed increased levels of active caspase-3 and increased cleavage of caspase-3 substrates, PARP and DFF45.	Staurosporine	29-42	poly(ADP-ribose) polymerase 1	Homo sapiens	147-151
18594935-5	2008	However, upon treatment with staurosporine, BRAt cells showed increased levels of active caspase-3 and increased cleavage of caspase-3 substrates, PARP and DFF45.	Staurosporine	29-42	DNA fragmentation factor subunit alpha	Homo sapiens	156-161
18534571-3	2008	Staurosporine increased caspase 3-like activity, DNA fragmentation, PARP cleavage, and the number of TUNEL positive cells consistent with the induction of apoptosis.	Staurosporine	0-13	caspase 3	Homo sapiens	24-33
18543255-0	2008	Staurosporine rapidly commits 3T3-F442A cells to the formation of adipocytes by activation of GSK-3beta and mobilization of calcium.	Staurosporine	0-13	glycogen synthase kinase 3 beta	Mus musculus	94-103
18543255-1	2008	Pre-adipose 3T3-F442A cells exposed to fetal bovine serum or human growth hormone (adipogenic medium) become irreversibly committed to differentiation into adipocytes within 24-36 h. We show now that the action of the serine-threonine kinase inhibitor staurosporine is much more rapid since its addition in non-adipogenic medium resulted in commitment to adipocyte differentiation within 4-6 h. During this period, glycogen synthase kinase 3beta was activated.	Staurosporine	252-265	growth hormone 1	Homo sapiens	67-81
18953090-10	2008	Moreover, neurosteroids appear to attenuate the staurosporine-induced cell damage in a caspase-3 independent way and their neuroprotective mechanism of action involves the increase in ERK-MAPK phosphorylation.	Staurosporine	48-61	caspase 3	Homo sapiens	87-96
18234541-12	2008	The addition of NAC, curcumin, PD98059, and staurosporine markedly inhibited the arecoline-induced HSP70 expression (p&lt;0.05).	Staurosporine	44-57	heat shock protein family A (Hsp70) member 4	Homo sapiens	99-104
18234541-15	2008	In addition, arecoline-induced HSP70 expression was downregulated by NAC, curcumin, PD98059, and staurosporine.	Staurosporine	97-110	heat shock protein family A (Hsp70) member 4	Homo sapiens	31-36
18582990-8	2008	The pretreatment with genistein, okdaic acid, U73122, GF109203x, and staurosporine attenuated hypoosmolarity-induced ANP release whereas orthovanadate augmented it significantly.	Staurosporine	69-82	natriuretic peptide A	Rattus norvegicus	117-120
18524862-5	2008	IGF-I was also shown to improve MSC survival following staurosporin-induced apoptosis in vitro.	Staurosporine	55-67	insulin-like growth factor 1	Mus musculus	0-5
18690848-3	2008	An increase in NUPR1 expression has been seen with serum starvation and in response to compounds such as cycloheximide, ceramide, and staurosporine.	Staurosporine	134-147	nuclear protein 1, transcriptional regulator	Homo sapiens	15-20
18620777-10	2008	Forced expression of WWOX in SNU387 cells decreased FGF2-mediated proliferation and enhanced apoptosis induced by staurosporine and the JNK inhibitor SP600129.	Staurosporine	114-127	WW domain containing oxidoreductase	Homo sapiens	21-25
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	Staurosporine	73-86	mitogen-activated protein kinase 1	Homo sapiens	126-163
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	Staurosporine	73-86	mitogen-activated protein kinase 1	Homo sapiens	165-168
18953090-5	2008	It was also shown that protective effects of DHEA, DHEAS and PGL against staurosporine-induced LDH release were attenuated by extracellular signal-regulated kinase (ERK)--mitogen-activated protein kinase (MAPK) inhibitor--PD 98059 (5 microM) but not by phosphatidylinositol-3-kinase (PI3-K) inhibitors such as LY 294002 (1 microM) or wortmannin (10 nM).	Staurosporine	73-86	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	253-282
18338251-0	2008	Role of inhibitor of apoptosis proteins and Smac/DIABLO in staurosporine-induced cerebellar granule neurons death.	Staurosporine	59-72	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	44-48
18338251-0	2008	Role of inhibitor of apoptosis proteins and Smac/DIABLO in staurosporine-induced cerebellar granule neurons death.	Staurosporine	59-72	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	49-55
18338251-7	2008	When CGN were treated with staurosporine we detected a decrease in cIAP-1 and cIAP-2, but not in XIAP and survivin levels.	Staurosporine	27-40	X-linked inhibitor of apoptosis	Rattus norvegicus	97-101
18338251-8	2008	Under these conditions Smac/DIABLO was released from the mitochondria suggesting its involvement in staurosporine-induced death of CGN.	Staurosporine	100-113	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	23-27
18338251-8	2008	Under these conditions Smac/DIABLO was released from the mitochondria suggesting its involvement in staurosporine-induced death of CGN.	Staurosporine	100-113	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	28-34
18534571-3	2008	Staurosporine increased caspase 3-like activity, DNA fragmentation, PARP cleavage, and the number of TUNEL positive cells consistent with the induction of apoptosis.	Staurosporine	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	68-72
18534571-6	2008	In isolated mitochondria, propranolol and ICI 118551 inhibited staurosporine-induced cytochrome c release while atenolol did not.	Staurosporine	63-76	cytochrome c, somatic	Homo sapiens	85-97
18589412-10	2008	Importantly, glutamate preconditioning increased Bcl-2 expression that was blocked by KN93, staurosporin and CRE-decoy oligonucleotide.	Staurosporine	92-104	BCL2 apoptosis regulator	Homo sapiens	49-54
18534571-7	2008	We conclude that propranolol and ICI 118551 protect SH-SY5Y cells against staurosporine-induced apoptosis through a dual action on the mitochondria and on caspase 9 in a cell type and an apoptotic paradigm where the conventional inhibitors of mitochondrial permeability transition such as cyclosporin A and bongkrekic acid demonstrate no protection.	Staurosporine	74-87	caspase 9	Homo sapiens	155-164
18439420-6	2008	The effects of ET-1 on astrocytic stromelysin-1 expression were inhibited by PD98059, staurosporine, and Ca(2+) chelation, but not by SB203580 or pyrrolidine dithiocarbamate.	Staurosporine	86-99	endothelin 1	Rattus norvegicus	15-19
18680225-11	2008	Staurosporine, a protein kinase C inhibitor, attenuated translocation of NF-kappaB induced by LPA.	Staurosporine	0-13	nuclear factor kappa B subunit 1	Homo sapiens	73-82
18452710-4	2008	Furthermore, translocation of Tbeta15 from cytosol to nuclei was observed in cultured neurons or HeLa cells during staurosporine (STS)-induced apoptosis, which was also verified by time-lapse imaging of YFP-tagged Tbeta15.	Staurosporine	115-128	tubulin, beta 2B class IIb	Rattus norvegicus	30-37
18452710-4	2008	Furthermore, translocation of Tbeta15 from cytosol to nuclei was observed in cultured neurons or HeLa cells during staurosporine (STS)-induced apoptosis, which was also verified by time-lapse imaging of YFP-tagged Tbeta15.	Staurosporine	130-133	tubulin, beta 2B class IIb	Rattus norvegicus	30-37
18480298-3	2008	Using a kinase inhibitor, staurosporin, and metabolic inhibitor, sodium azide, relatively high turnover of ezrin T567 phosphorylation was observed in all three epithelia.	Staurosporine	26-38	ezrin	Homo sapiens	107-112
18395766-0	2008	Protection against heat and staurosporine mediated apoptosis by the HSV-1 US11 protein.	Staurosporine	28-41	tegument protein US11	Human alphaherpesvirus 1	74-78
18395766-6	2008	Moreover, US11 expression also protected against staurosporine induced apoptosis.	Staurosporine	49-62	tegument protein US11	Human alphaherpesvirus 1	10-14
18405662-7	2008	However, we demonstrate that both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity were not affected by TMP21 over-expression or depletion.	Staurosporine	34-47	caspase 3	Homo sapiens	59-68
18405662-7	2008	However, we demonstrate that both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity were not affected by TMP21 over-expression or depletion.	Staurosporine	34-47	tumor protein p53	Homo sapiens	81-84
18405662-7	2008	However, we demonstrate that both staurosporine-stimulated caspase-3 activation, p53 and neprilysin expression and activity were not affected by TMP21 over-expression or depletion.	Staurosporine	34-47	membrane metalloendopeptidase	Homo sapiens	89-99
18413141-2	2008	In this study, we investigated the mechanisms underlying the neuroprotective effects of calbindin-D28K in staurosporine (STS)-induced apoptosis and 1-methyl-4-phenylpyridinium (MPP(+))-induced necrosis.	Staurosporine	106-119	calbindin 1	Mus musculus	88-92
18413141-2	2008	In this study, we investigated the mechanisms underlying the neuroprotective effects of calbindin-D28K in staurosporine (STS)-induced apoptosis and 1-methyl-4-phenylpyridinium (MPP(+))-induced necrosis.	Staurosporine	121-124	calbindin 1	Mus musculus	88-92
18560593-9	2008	We report that PINK1 plays a neuroprotective role in the mitochondria of mammalian neurons, especially against stress such as staurosporine.	Staurosporine	126-139	PTEN induced kinase 1	Homo sapiens	15-20
18223679-3	2008	Here, we genetically evaluated the protective roles of both TERT and telomerase activity against cell death induced by staurosporine (STS) and N-methyl-D-aspartic acid (NMDA).	Staurosporine	119-132	telomerase reverse transcriptase	Mus musculus	60-64
18445618-7	2008	Cell stress induced by staurosporine results in the nuclear translocation and activation of C6 and an increase in 586 amino acid fragments of huntingtin in the nucleus.	Staurosporine	23-36	huntingtin	Mus musculus	142-152
18478334-4	2008	It was found that hypertonic stress reduces staurosporine-induced AVD and cell death (associated with caspase-3/7 activation and DNA fragmentation), and that this effect was actually due to activation of the HICC.	Staurosporine	44-57	caspase 3	Homo sapiens	102-111
17922126-10	2008	H(2)O(2)-induced JNK phosphorylation and ERK phosphorylation were inhibited by staurosporine, protein kinase C (PKC) inhibitor.	Staurosporine	79-92	mitogen-activated protein kinase 8	Homo sapiens	17-20
17922126-10	2008	H(2)O(2)-induced JNK phosphorylation and ERK phosphorylation were inhibited by staurosporine, protein kinase C (PKC) inhibitor.	Staurosporine	79-92	mitogen-activated protein kinase 1	Homo sapiens	41-44
18641691-1	2008	Staurosporine, a protein kinase C (PKC) inhibitor, has been reported to regulate the phosphorylation of ERK1/2 in several cell lines.	Staurosporine	0-13	mitogen activated protein kinase 3	Rattus norvegicus	104-110
18434089-8	2008	Suramin (a P2-purinoceptor antagonist), neomycin (a PLC inhibitor), staurosporin (a PKC inhibitor), and PD98059 (a MEK inhibitor) significantly attenuated the ATP-induced activation of MAPK.	Staurosporine	68-80	mitogen-activated protein kinase 3	Homo sapiens	185-189
18511295-4	2008	We provide biochemical evidence that a caspase(s)-cleaved NH2-terminal tau fragment of 20-22 kDa, consistent with the size of the NH2 26-230aa neurotoxic fragment of tau, is generated in vitro in differentiated human SH-SY5Y cells undergoing apoptosis by BDNF withdrawal or following treatment with staurosporine.	Staurosporine	299-312	microtubule associated protein tau	Homo sapiens	71-74
18511295-4	2008	We provide biochemical evidence that a caspase(s)-cleaved NH2-terminal tau fragment of 20-22 kDa, consistent with the size of the NH2 26-230aa neurotoxic fragment of tau, is generated in vitro in differentiated human SH-SY5Y cells undergoing apoptosis by BDNF withdrawal or following treatment with staurosporine.	Staurosporine	299-312	microtubule associated protein tau	Homo sapiens	166-169
18638274-4	2008	We demonstrated that epidermal growth factor (EGF) stimulation of fibroblast NR6WT expressing human EGF receptors blocks staurosporine-induced apoptosis by inhibiting the activation of caspase-3.	Staurosporine	121-134	epidermal growth factor	Homo sapiens	21-44
18638274-4	2008	We demonstrated that epidermal growth factor (EGF) stimulation of fibroblast NR6WT expressing human EGF receptors blocks staurosporine-induced apoptosis by inhibiting the activation of caspase-3.	Staurosporine	121-134	epidermal growth factor	Homo sapiens	46-49
18638274-4	2008	We demonstrated that epidermal growth factor (EGF) stimulation of fibroblast NR6WT expressing human EGF receptors blocks staurosporine-induced apoptosis by inhibiting the activation of caspase-3.	Staurosporine	121-134	epidermal growth factor	Homo sapiens	100-103
18638274-4	2008	We demonstrated that epidermal growth factor (EGF) stimulation of fibroblast NR6WT expressing human EGF receptors blocks staurosporine-induced apoptosis by inhibiting the activation of caspase-3.	Staurosporine	121-134	caspase 3	Homo sapiens	185-194
18638274-6	2008	Furthermore, by using KP372-1, a specific Akt inhibitor, we found that downstream of Akt signaling pathways is absolutely required for the EGF rescue from staurosporine-induced apoptosis in NR6WT.	Staurosporine	155-168	AKT serine/threonine kinase 1	Homo sapiens	42-45
18638274-6	2008	Furthermore, by using KP372-1, a specific Akt inhibitor, we found that downstream of Akt signaling pathways is absolutely required for the EGF rescue from staurosporine-induced apoptosis in NR6WT.	Staurosporine	155-168	AKT serine/threonine kinase 1	Homo sapiens	85-88
18638274-6	2008	Furthermore, by using KP372-1, a specific Akt inhibitor, we found that downstream of Akt signaling pathways is absolutely required for the EGF rescue from staurosporine-induced apoptosis in NR6WT.	Staurosporine	155-168	epidermal growth factor	Homo sapiens	139-142
18638274-8	2008	These findings indicate that EGF receptor activation provides survival response against staurosporine-induced apoptosis through signal pathways of PI3K and Rac, which then may prevent the activation of caspase-3.	Staurosporine	88-101	epidermal growth factor	Homo sapiens	29-32
18638274-8	2008	These findings indicate that EGF receptor activation provides survival response against staurosporine-induced apoptosis through signal pathways of PI3K and Rac, which then may prevent the activation of caspase-3.	Staurosporine	88-101	AKT serine/threonine kinase 1	Homo sapiens	147-159
18638274-8	2008	These findings indicate that EGF receptor activation provides survival response against staurosporine-induced apoptosis through signal pathways of PI3K and Rac, which then may prevent the activation of caspase-3.	Staurosporine	88-101	caspase 3	Homo sapiens	202-211
18439420-6	2008	The effects of ET-1 on astrocytic stromelysin-1 expression were inhibited by PD98059, staurosporine, and Ca(2+) chelation, but not by SB203580 or pyrrolidine dithiocarbamate.	Staurosporine	86-99	matrix metallopeptidase 3	Rattus norvegicus	34-47
18506371-4	2008	Regucalcin mRNA expression was significantly decreased after culture with tumor necrosis factor-alpha (1 or 10 ng/ml of medium) for 24 or 48 h. The effect of PTH or IGF-I in increasing regucalcin mRNA expression was not seen in the presence of staurosporine (10(-8) M), an inhibitor of protein kinase C, or PD98059 (10(-7) M), an inhibitor of mitosis-activated protein kinase (MAP kinase), respectively, suggesting that regucalcin mRNA expression is enhanced through intracellular signaling factors.	Staurosporine	244-257	regucalcin	Mus musculus	0-10
18281372-8	2008	The in vitro study demonstrated that TNFalpha significantly increased CD40L expression, an effect weakly influenced by aspirin but significantly reduced by AACOCF3, an inhibitor of PLA(2), apocynin, an inhibitor of NADPH oxidase, or staurosporine, an inhibitor of PKC.	Staurosporine	233-246	tumor necrosis factor	Homo sapiens	37-45
18281372-8	2008	The in vitro study demonstrated that TNFalpha significantly increased CD40L expression, an effect weakly influenced by aspirin but significantly reduced by AACOCF3, an inhibitor of PLA(2), apocynin, an inhibitor of NADPH oxidase, or staurosporine, an inhibitor of PKC.	Staurosporine	233-246	CD40 ligand	Homo sapiens	70-75
18506371-4	2008	Regucalcin mRNA expression was significantly decreased after culture with tumor necrosis factor-alpha (1 or 10 ng/ml of medium) for 24 or 48 h. The effect of PTH or IGF-I in increasing regucalcin mRNA expression was not seen in the presence of staurosporine (10(-8) M), an inhibitor of protein kinase C, or PD98059 (10(-7) M), an inhibitor of mitosis-activated protein kinase (MAP kinase), respectively, suggesting that regucalcin mRNA expression is enhanced through intracellular signaling factors.	Staurosporine	244-257	tumor necrosis factor	Mus musculus	74-101
18506371-4	2008	Regucalcin mRNA expression was significantly decreased after culture with tumor necrosis factor-alpha (1 or 10 ng/ml of medium) for 24 or 48 h. The effect of PTH or IGF-I in increasing regucalcin mRNA expression was not seen in the presence of staurosporine (10(-8) M), an inhibitor of protein kinase C, or PD98059 (10(-7) M), an inhibitor of mitosis-activated protein kinase (MAP kinase), respectively, suggesting that regucalcin mRNA expression is enhanced through intracellular signaling factors.	Staurosporine	244-257	parathyroid hormone	Mus musculus	158-161
18506371-4	2008	Regucalcin mRNA expression was significantly decreased after culture with tumor necrosis factor-alpha (1 or 10 ng/ml of medium) for 24 or 48 h. The effect of PTH or IGF-I in increasing regucalcin mRNA expression was not seen in the presence of staurosporine (10(-8) M), an inhibitor of protein kinase C, or PD98059 (10(-7) M), an inhibitor of mitosis-activated protein kinase (MAP kinase), respectively, suggesting that regucalcin mRNA expression is enhanced through intracellular signaling factors.	Staurosporine	244-257	insulin-like growth factor 1	Mus musculus	165-170
18079751-5	2008	Here, we demonstrate that IGF1 impairs the onset of tumor necrosis factor-related apoptosis-inducing ligand and staurosporine-induced apoptosis in melanoma cells expressing either wild-type or oncogenic B-Raf.	Staurosporine	112-125	insulin like growth factor 1	Homo sapiens	26-30
18163394-0	2008	Bcl-xL prevents staurosporine-induced hepatocyte apoptosis by restoring protein kinase B/mitogen-activated protein kinase activity and mitochondria integrity.	Staurosporine	16-29	Bcl2-like 1	Rattus norvegicus	0-6
18163394-2	2008	Staurosporine induced apparent cleavage of caspase-8, caspase-9, and caspase-3.	Staurosporine	0-13	caspase 8	Rattus norvegicus	43-52
18163394-2	2008	Staurosporine induced apparent cleavage of caspase-8, caspase-9, and caspase-3.	Staurosporine	0-13	caspase 9	Rattus norvegicus	54-63
18163394-2	2008	Staurosporine induced apparent cleavage of caspase-8, caspase-9, and caspase-3.	Staurosporine	0-13	caspase 3	Rattus norvegicus	69-78
18163394-3	2008	The release of cytochrome c from mitochondria, and Bid activation were also detected in staurosporine-treated primary hepatocytes.	Staurosporine	88-101	BH3 interacting domain death agonist	Rattus norvegicus	51-54
18163394-5	2008	Bcl-x(L) overexpression protected from "loss of" mitochondrial transmembrane potential and prevented staurosporine-induced caspase-3 and caspase-8 cleavage.	Staurosporine	101-114	Bcl2-like 1	Rattus norvegicus	0-8
18163394-5	2008	Bcl-x(L) overexpression protected from "loss of" mitochondrial transmembrane potential and prevented staurosporine-induced caspase-3 and caspase-8 cleavage.	Staurosporine	101-114	caspase 3	Rattus norvegicus	123-132
18163394-5	2008	Bcl-x(L) overexpression protected from "loss of" mitochondrial transmembrane potential and prevented staurosporine-induced caspase-3 and caspase-8 cleavage.	Staurosporine	101-114	caspase 8	Rattus norvegicus	137-146
18163394-6	2008	Overexpression of constitutively active ERK and PKB inhibited staurosporine-induced caspase-3 activation and hepatocyte death.	Staurosporine	62-75	Eph receptor B1	Rattus norvegicus	40-43
18163394-6	2008	Overexpression of constitutively active ERK and PKB inhibited staurosporine-induced caspase-3 activation and hepatocyte death.	Staurosporine	62-75	caspase 3	Rattus norvegicus	84-93
18163394-7	2008	PI3K inhibitor (LY294002) and ERK inhibitor (PD98059) significantly reversed the protective effects of Bcl-x(L) on staurosporine-induced hepatocyte death.	Staurosporine	115-128	Eph receptor B1	Rattus norvegicus	30-33
18163394-7	2008	PI3K inhibitor (LY294002) and ERK inhibitor (PD98059) significantly reversed the protective effects of Bcl-x(L) on staurosporine-induced hepatocyte death.	Staurosporine	115-128	Bcl2-like 1	Rattus norvegicus	103-111
18163394-8	2008	Our data suggest that Bcl-x(L) prevents staurosporine-induced hepatocyte apoptosis by modulating protein kinase B and p44/42 mitogen-activated protein kinase activity and disrupts mitochondria death signaling.	Staurosporine	40-53	Bcl2-like 1	Rattus norvegicus	22-27
18163394-8	2008	Our data suggest that Bcl-x(L) prevents staurosporine-induced hepatocyte apoptosis by modulating protein kinase B and p44/42 mitogen-activated protein kinase activity and disrupts mitochondria death signaling.	Staurosporine	40-53	mitogen activated protein kinase 3	Rattus norvegicus	118-121
18079751-5	2008	Here, we demonstrate that IGF1 impairs the onset of tumor necrosis factor-related apoptosis-inducing ligand and staurosporine-induced apoptosis in melanoma cells expressing either wild-type or oncogenic B-Raf.	Staurosporine	112-125	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	203-208
18424168-6	2008	In addition, exogenous SYNPO in PtK2 cells suppressed staurosporine-dependent disruption of F-actin stress fibers, suggesting that SYNPO protected F-actin from disruption.	Staurosporine	54-67	synaptopodin	Homo sapiens	23-28
18424168-6	2008	In addition, exogenous SYNPO in PtK2 cells suppressed staurosporine-dependent disruption of F-actin stress fibers, suggesting that SYNPO protected F-actin from disruption.	Staurosporine	54-67	protein tyrosine kinase 2	Homo sapiens	32-36
18497968-7	2008	AKAP149 was also cleaved by caspases during Fas- and staurosporine-induced apoptosis in Jurkat T and HeLa cells, which were blocked by specific inhibitors of caspase-3 and -8.	Staurosporine	53-66	A-kinase anchoring protein 1	Homo sapiens	0-7
18497968-7	2008	AKAP149 was also cleaved by caspases during Fas- and staurosporine-induced apoptosis in Jurkat T and HeLa cells, which were blocked by specific inhibitors of caspase-3 and -8.	Staurosporine	53-66	caspase 1	Homo sapiens	28-36
18497968-7	2008	AKAP149 was also cleaved by caspases during Fas- and staurosporine-induced apoptosis in Jurkat T and HeLa cells, which were blocked by specific inhibitors of caspase-3 and -8.	Staurosporine	53-66	caspase 3	Homo sapiens	158-174
18497968-9	2008	In addition, HeLa cells transiently overexpressing AKAP149 D582E mutant were resistant to staurosporine-induced HeLa cell apoptosis.	Staurosporine	90-103	A-kinase anchoring protein 1	Homo sapiens	51-58
18389485-5	2008	TSB also suppressed the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons.	Staurosporine	99-112	BCL2, apoptosis regulator	Rattus norvegicus	59-64
18389485-5	2008	TSB also suppressed the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons.	Staurosporine	99-112	caspase 3	Rattus norvegicus	69-78
18385140-8	2008	Finally, we show that induction of apoptosis by treatment with staurosporine causes translocation of DSP18 from the intermembrane space into the cytosol similar to other apoptogenic factors such as cytochrome c.	Staurosporine	63-76	dual specificity phosphatase 18	Homo sapiens	101-106
18385140-8	2008	Finally, we show that induction of apoptosis by treatment with staurosporine causes translocation of DSP18 from the intermembrane space into the cytosol similar to other apoptogenic factors such as cytochrome c.	Staurosporine	63-76	cytochrome c, somatic	Homo sapiens	198-210
18420943-7	2008	This ADAM10-mediated proteolysis could be induced by Ca(2+) influx and staurosporine treatment, indicating that ADAM10-mediated VE-cadherin cleavage contributes to the dissolution of adherens junctions during endothelial cell activation and apoptosis, respectively.	Staurosporine	71-84	ADAM metallopeptidase domain 10	Homo sapiens	5-11
18420943-7	2008	This ADAM10-mediated proteolysis could be induced by Ca(2+) influx and staurosporine treatment, indicating that ADAM10-mediated VE-cadherin cleavage contributes to the dissolution of adherens junctions during endothelial cell activation and apoptosis, respectively.	Staurosporine	71-84	ADAM metallopeptidase domain 10	Homo sapiens	112-118
18420943-7	2008	This ADAM10-mediated proteolysis could be induced by Ca(2+) influx and staurosporine treatment, indicating that ADAM10-mediated VE-cadherin cleavage contributes to the dissolution of adherens junctions during endothelial cell activation and apoptosis, respectively.	Staurosporine	71-84	cadherin 5	Homo sapiens	128-139
18071308-1	2008	PKC412 is a staurosporine derivative that inhibits several protein kinases including FLT3, and is highly anticipated as a novel therapeutic agent for acute myeloblastic leukemia (AML) carrying FLT3 mutations.	Staurosporine	12-25	fms related receptor tyrosine kinase 3	Homo sapiens	85-89
18425353-7	2008	The effect of PMA in increasing nuclear regucalcin levels was completely absent in culture with staurosporine (10(-8) M).	Staurosporine	96-109	regucalcin	Rattus norvegicus	40-50
18308720-7	2008	HK-I-mediated inhibition of cytochrome c release induced by staurosporine was also diminished in cells expressing VDAC1 mutants.	Staurosporine	60-73	hexokinase 1	Mus musculus	0-4
18308720-7	2008	HK-I-mediated inhibition of cytochrome c release induced by staurosporine was also diminished in cells expressing VDAC1 mutants.	Staurosporine	60-73	voltage-dependent anion channel 1	Mus musculus	114-119
18272519-5	2008	IkappaBbeta mRNA knock down also reduced resistance to staurosporine-induced apoptosis and decreased in vitro invasiveness.	Staurosporine	55-68	NFKB inhibitor beta	Homo sapiens	0-11
18425353-8	2008	The nuclear localization of regucalcin in the stable regucalcin/pCXN2-transfected cells (transfectant) increased markedly as compared with that of wild-type cells, whereas the increase was less evident in the transfectants cultured with staurosporine.	Staurosporine	237-250	regucalcin	Rattus norvegicus	28-38
18189315-10	2008	Furthermore, as shown by calcein assay, DHEA, DHEAS, and PGL increased viability of staurosporine-treated cells, and these effects were attenuated by specific inhibitors of phosphatidylinositol 3-kinase (PI3-K) and extracellular signal-regulated protein kinase (ERK)-mitogen activated protein kinase (MAPK).	Staurosporine	84-97	sulfotransferase family 2A member 1	Homo sapiens	46-51
18189315-10	2008	Furthermore, as shown by calcein assay, DHEA, DHEAS, and PGL increased viability of staurosporine-treated cells, and these effects were attenuated by specific inhibitors of phosphatidylinositol 3-kinase (PI3-K) and extracellular signal-regulated protein kinase (ERK)-mitogen activated protein kinase (MAPK).	Staurosporine	84-97	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	173-202
18189315-10	2008	Furthermore, as shown by calcein assay, DHEA, DHEAS, and PGL increased viability of staurosporine-treated cells, and these effects were attenuated by specific inhibitors of phosphatidylinositol 3-kinase (PI3-K) and extracellular signal-regulated protein kinase (ERK)-mitogen activated protein kinase (MAPK).	Staurosporine	84-97	mitogen-activated protein kinase 1	Homo sapiens	215-260
18189315-10	2008	Furthermore, as shown by calcein assay, DHEA, DHEAS, and PGL increased viability of staurosporine-treated cells, and these effects were attenuated by specific inhibitors of phosphatidylinositol 3-kinase (PI3-K) and extracellular signal-regulated protein kinase (ERK)-mitogen activated protein kinase (MAPK).	Staurosporine	84-97	mitogen-activated protein kinase 1	Homo sapiens	262-265
18189315-10	2008	Furthermore, as shown by calcein assay, DHEA, DHEAS, and PGL increased viability of staurosporine-treated cells, and these effects were attenuated by specific inhibitors of phosphatidylinositol 3-kinase (PI3-K) and extracellular signal-regulated protein kinase (ERK)-mitogen activated protein kinase (MAPK).	Staurosporine	84-97	mitogen-activated protein kinase 1	Homo sapiens	301-305
18313772-3	2008	Accordingly, PKC inhibitors (staurosporine, Go-6976, Go-6983, Ro-318220, BIS-1, chelerythrine, rottlerin, quercetin) enhanced NT receptor binding and NT-induced inositol phosphate (IP) formation.	Staurosporine	29-42	protein kinase C delta	Homo sapiens	13-16
18307263-5	2008	Both mutations (p.A244G and p.V317I) were found to abolish the protective effect of wild-type PINK1 against staurosporine-induced apoptosis.	Staurosporine	108-121	PTEN induced kinase 1	Homo sapiens	94-99
18425924-4	2008	Huperzine A is a linearly competitive, reversible inhibitor of acetyl cholinesterase that is said to have both central and peripheral activity with the ability to protect cells against hydrogen peroxide, beta-amyloid protein (or peptide), glutamate, ischemia and staurosporine-induced cytotoxicity and apoptosis.	Staurosporine	263-276	butyrylcholinesterase	Homo sapiens	70-84
18358497-2	2008	As expected, exposure of mu-opioid receptor (MOR)-transfected HEK-293 cells to either DAMGO (a specific mu-opioid agonist) or etorphine (a wide spectrum opioid agonist) resulted in down regulation of the receptors that was blocked by the kinase inhibitor staurosporine, by hypertonic sucrose and by the lysosomal and proteasomal inhibitors chloroquine and lactacystin.	Staurosporine	255-268	opioid receptor mu 1	Homo sapiens	25-43
18048804-6	2008	Acrolein-mediated HO-1 induction was significantly attenuated by pan-protein kinase C (PKC) inhibitors RO318220, staurosporine, and PKC-delta selective inhibitor rottlerin and PKC-delta small interfering RNA.	Staurosporine	113-126	heme oxygenase 1	Homo sapiens	18-22
18048804-6	2008	Acrolein-mediated HO-1 induction was significantly attenuated by pan-protein kinase C (PKC) inhibitors RO318220, staurosporine, and PKC-delta selective inhibitor rottlerin and PKC-delta small interfering RNA.	Staurosporine	113-126	protein kinase C delta	Homo sapiens	87-90
18358497-2	2008	As expected, exposure of mu-opioid receptor (MOR)-transfected HEK-293 cells to either DAMGO (a specific mu-opioid agonist) or etorphine (a wide spectrum opioid agonist) resulted in down regulation of the receptors that was blocked by the kinase inhibitor staurosporine, by hypertonic sucrose and by the lysosomal and proteasomal inhibitors chloroquine and lactacystin.	Staurosporine	255-268	opioid receptor mu 1	Homo sapiens	45-48
18223165-4	2008	In addition to resistance against T-cell destruction, B7-H1+ cancer cells also become refractory to apoptosis induced by Fas ligation or the protein kinase inhibitor Staurosporine.	Staurosporine	166-179	CD274 antigen	Mus musculus	54-59
17950294-11	2008	After pre-incubation with DHA, VEGF-, TNF-alpha- and staurosporine-induced phosphorylation of Akt was decreased when compared to AA.	Staurosporine	53-66	vascular endothelial growth factor A	Homo sapiens	31-35
17950294-11	2008	After pre-incubation with DHA, VEGF-, TNF-alpha- and staurosporine-induced phosphorylation of Akt was decreased when compared to AA.	Staurosporine	53-66	AKT serine/threonine kinase 1	Homo sapiens	94-97
17950294-13	2008	In addition, DHA in comparison to AA augmented staurosporine-mediated increase in caspase-3 activity.	Staurosporine	47-60	caspase 3	Homo sapiens	82-91
17879947-4	2008	We observed that the pretreatment of HL-60 cells with TLCK or TPCK diminished caspases 3 and -7 (DEVDase) and caspase-6 (VEIDase) activity in response to various cell death inducing stimuli such as staurosporine (STS), etoposide (ETP), or N6-(2-isopentenyl)adenosine.	Staurosporine	198-211	caspase 6	Homo sapiens	110-119
18430996-4	2008	We found that K252a is differentiated from staurosporine by its inhibition of ERK2: both compounds are structurally related microbial metabolites generally believed to have only moderate kinase selectivity.	Staurosporine	43-56	mitogen-activated protein kinase 1	Homo sapiens	78-82
18026170-8	2008	Apoptosis of HO-1 transduced cells was reduced by 50% in vitro after staurosporine induction.	Staurosporine	69-82	heme oxygenase 1	Sus scrofa	13-17
18212057-4	2008	Oncogenic C-RAF decreased the percentage of apoptotic cells following treatment with staurosporine or the oxidative stress-inducing agent tert-butyl hydroperoxide.	Staurosporine	85-98	v-raf-leukemia viral oncogene 1	Mus musculus	10-15
18664199-0	2008	[Effect of staurosporine induced apoptosis of MCF7/GFP-Bax stable cell line on Bax translocation from cytosol into mitochondria].	Staurosporine	11-24	BCL2 associated X, apoptosis regulator	Homo sapiens	55-58
18664199-0	2008	[Effect of staurosporine induced apoptosis of MCF7/GFP-Bax stable cell line on Bax translocation from cytosol into mitochondria].	Staurosporine	11-24	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
18664199-1	2008	To investigate Bax translocation from cytosol into mitochondria induced by staurosporine (STS) in GFP-Bax-tagged MCF7 stable cell line, the viability was measured by MTT method.	Staurosporine	75-88	BCL2 associated X, apoptosis regulator	Homo sapiens	15-18
18664199-1	2008	To investigate Bax translocation from cytosol into mitochondria induced by staurosporine (STS) in GFP-Bax-tagged MCF7 stable cell line, the viability was measured by MTT method.	Staurosporine	75-88	BCL2 associated X, apoptosis regulator	Homo sapiens	102-105
18664199-1	2008	To investigate Bax translocation from cytosol into mitochondria induced by staurosporine (STS) in GFP-Bax-tagged MCF7 stable cell line, the viability was measured by MTT method.	Staurosporine	90-93	BCL2 associated X, apoptosis regulator	Homo sapiens	15-18
18664199-1	2008	To investigate Bax translocation from cytosol into mitochondria induced by staurosporine (STS) in GFP-Bax-tagged MCF7 stable cell line, the viability was measured by MTT method.	Staurosporine	90-93	BCL2 associated X, apoptosis regulator	Homo sapiens	102-105
18664199-7	2008	The results showed that STS can induce Bax translocation from cytoplasm to mitochondria, Cyt-c release from mitochondria and Annexin V label.	Staurosporine	24-27	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
18664199-7	2008	The results showed that STS can induce Bax translocation from cytoplasm to mitochondria, Cyt-c release from mitochondria and Annexin V label.	Staurosporine	24-27	annexin A5	Homo sapiens	125-134
18275940-4	2008	We demonstrate that cytoplasmic-tail phosphorylation specifically at amino-acid residue T668 (APP-695 numbering) increases during staurosporine-induced apoptosis, in parallel with activation of the mitogen-activated, proline-directed serine/threonine protein kinase ERK1.	Staurosporine	130-143	mitogen activated protein kinase 3	Rattus norvegicus	266-270
18275940-5	2008	We demonstrate additionally that specific ERK inhibition during staurosporine induction, with serum-free conditions, results in down-regulation of APP phosphorylation at T668, together with attenuation of the increased Abeta-secretory response.	Staurosporine	64-77	Eph receptor B1	Rattus norvegicus	42-45
18188704-9	2008	However, BLOC1S2 and HIPPI sensitize NCH89 glioblastoma cells to the pro-apoptotic actions of staurosporine and the death ligand TRAIL by enhancing caspase activation, cytochrome c release, and disruption of the mitochondrial membrane potential.	Staurosporine	94-107	biogenesis of lysosomal organelles complex 1 subunit 2	Homo sapiens	9-16
18188704-9	2008	However, BLOC1S2 and HIPPI sensitize NCH89 glioblastoma cells to the pro-apoptotic actions of staurosporine and the death ligand TRAIL by enhancing caspase activation, cytochrome c release, and disruption of the mitochondrial membrane potential.	Staurosporine	94-107	intraflagellar transport 57	Homo sapiens	21-26
18188704-9	2008	However, BLOC1S2 and HIPPI sensitize NCH89 glioblastoma cells to the pro-apoptotic actions of staurosporine and the death ligand TRAIL by enhancing caspase activation, cytochrome c release, and disruption of the mitochondrial membrane potential.	Staurosporine	94-107	cytochrome c, somatic	Homo sapiens	168-180
17914455-5	2008	Shb knockdown increases the susceptibility of SVR cells to the apoptotic agents, cisplatin and staurosporine.	Staurosporine	95-108	src homology 2 domain-containing transforming protein B	Mus musculus	0-3
17914455-8	2008	The altered FAK activity coincided with an elongated cell phenotype that was particularly noticeable in the presence of staurosporine.	Staurosporine	120-133	PTK2 protein tyrosine kinase 2	Mus musculus	12-15
17935972-5	2008	The importance of the dephosphorylation of TORC has been suggested by the fact that a kinase inhibitor staurosporine induces dephosphorylation of TORC and upregulates the gene expression of CYP11A, CYP11B1, CYP11B2 and StAR in adrenocortical cells.	Staurosporine	103-116	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	190-196
17935972-5	2008	The importance of the dephosphorylation of TORC has been suggested by the fact that a kinase inhibitor staurosporine induces dephosphorylation of TORC and upregulates the gene expression of CYP11A, CYP11B1, CYP11B2 and StAR in adrenocortical cells.	Staurosporine	103-116	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	198-205
17935972-5	2008	The importance of the dephosphorylation of TORC has been suggested by the fact that a kinase inhibitor staurosporine induces dephosphorylation of TORC and upregulates the gene expression of CYP11A, CYP11B1, CYP11B2 and StAR in adrenocortical cells.	Staurosporine	103-116	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	207-214
17935972-5	2008	The importance of the dephosphorylation of TORC has been suggested by the fact that a kinase inhibitor staurosporine induces dephosphorylation of TORC and upregulates the gene expression of CYP11A, CYP11B1, CYP11B2 and StAR in adrenocortical cells.	Staurosporine	103-116	steroidogenic acute regulatory protein	Rattus norvegicus	219-223
18189315-7	2008	DHEAS, DHEA, and PGL significantly antagonized effects of staurosporine on both caspase-3 activity and mitochondrial membrane potential.	Staurosporine	58-71	sulfotransferase family 2A member 1	Homo sapiens	0-5
18189315-7	2008	DHEAS, DHEA, and PGL significantly antagonized effects of staurosporine on both caspase-3 activity and mitochondrial membrane potential.	Staurosporine	58-71	caspase 3	Homo sapiens	80-89
18164589-7	2008	Stimulation of glucose uptake and induction of GLUT4 translocation in cardiac myocytes by contraction and oligomycin each were sensitive to inhibition by the PKC/PKD inhibitors staurosporin and calphostin-C.	Staurosporine	177-189	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	47-52
18164589-7	2008	Stimulation of glucose uptake and induction of GLUT4 translocation in cardiac myocytes by contraction and oligomycin each were sensitive to inhibition by the PKC/PKD inhibitors staurosporin and calphostin-C.	Staurosporine	177-189	protein kinase D1	Mus musculus	162-165
18243176-10	2008	Compared to untreated RGC-5 cells, cells treated with Staurosporine differentiated, synthesized and secreted elevated levels of tPA and uPA, and underwent cell death.	Staurosporine	54-67	plasminogen activator, tissue	Mus musculus	128-131
18243176-10	2008	Compared to untreated RGC-5 cells, cells treated with Staurosporine differentiated, synthesized and secreted elevated levels of tPA and uPA, and underwent cell death.	Staurosporine	54-67	plasminogen activator, urokinase	Mus musculus	136-139
18243176-11	2008	In contrast, when RGC-5 cells were treated with Staurosporine along with the receptor associated protein (RAP), proteolytic activities of both tPA and uPA were significantly reduced.	Staurosporine	48-61	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	77-104
18243176-11	2008	In contrast, when RGC-5 cells were treated with Staurosporine along with the receptor associated protein (RAP), proteolytic activities of both tPA and uPA were significantly reduced.	Staurosporine	48-61	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	106-109
18243176-11	2008	In contrast, when RGC-5 cells were treated with Staurosporine along with the receptor associated protein (RAP), proteolytic activities of both tPA and uPA were significantly reduced.	Staurosporine	48-61	plasminogen activator, tissue	Mus musculus	143-146
18243176-11	2008	In contrast, when RGC-5 cells were treated with Staurosporine along with the receptor associated protein (RAP), proteolytic activities of both tPA and uPA were significantly reduced.	Staurosporine	48-61	plasminogen activator, urokinase	Mus musculus	151-154
18199803-4	2008	In vitro, tPA inhibited staurosporine or H(2)O(2)-induced caspase-3 activation, prevented cellular DNA fragmentation, and suppressed the release of cytochrome C from mitochondria into the cytosol in a rat interstitial fibroblast cell line (NRK-49F).	Staurosporine	24-37	plasminogen activator, tissue type	Rattus norvegicus	10-13
17996985-5	2008	Wortmannin (10 nM) and LY 294002 (10 microM) (inhibitors of phosphatidylinositol-3-kinase, PI3-K) reversed the inhibitory effect of memantine on the staurosporine-induced LDH release, suggesting that the PI3-K/Akt prosurvival pathway is a possible target for antiapoptotic action of memantine.	Staurosporine	149-162	AKT serine/threonine kinase 1	Homo sapiens	210-213
18204996-4	2008	Interestingly, IL-1beta, IL-6, and iNOS expression was significantly attenuated by treatment with protein kinase C (PKC) inhibitor (staurosporine) as well as p38 MAP kinase inhibitor (SKF86002) in LPS-stimulated RAW 264.7 cells.	Staurosporine	132-145	interleukin 1 beta	Mus musculus	15-23
18204996-4	2008	Interestingly, IL-1beta, IL-6, and iNOS expression was significantly attenuated by treatment with protein kinase C (PKC) inhibitor (staurosporine) as well as p38 MAP kinase inhibitor (SKF86002) in LPS-stimulated RAW 264.7 cells.	Staurosporine	132-145	interleukin 6	Mus musculus	25-29
18204996-4	2008	Interestingly, IL-1beta, IL-6, and iNOS expression was significantly attenuated by treatment with protein kinase C (PKC) inhibitor (staurosporine) as well as p38 MAP kinase inhibitor (SKF86002) in LPS-stimulated RAW 264.7 cells.	Staurosporine	132-145	nitric oxide synthase 2, inducible	Mus musculus	35-39
18338825-2	2008	Here, we show that LIF protects mature rat OLG cultures selectively against the combined insult of the proinflammatory cytokines interferon-gamma and tumor necrosis factor-alpha, but it does not protect against oxidative stress nor against staurosporine induced apoptosis.	Staurosporine	240-253	LIF, interleukin 6 family cytokine	Rattus norvegicus	19-22
17724463-4	2008	We found that MCF-7/GFP-Bak cells showed an increased sensitivity to apoptosis induction by staurosporine, actinomycin D, TRAIL and overexpression of Puma compared to GFP-Bax-expressing cells.	Staurosporine	92-105	BCL2 antagonist/killer 1	Homo sapiens	24-27
17724464-4	2008	Bfl-1/Bak interaction is functional as Bfl-1 suppressed staurosporine (STS)-induced apoptosis in wild-type and Bax-deficient cells, but not in Bak-/- cells.	Staurosporine	56-69	BCL2 related protein A1	Homo sapiens	0-5
17724464-4	2008	Bfl-1/Bak interaction is functional as Bfl-1 suppressed staurosporine (STS)-induced apoptosis in wild-type and Bax-deficient cells, but not in Bak-/- cells.	Staurosporine	56-69	BCL2 antagonist/killer 1	Homo sapiens	6-9
17724464-4	2008	Bfl-1/Bak interaction is functional as Bfl-1 suppressed staurosporine (STS)-induced apoptosis in wild-type and Bax-deficient cells, but not in Bak-/- cells.	Staurosporine	56-69	BCL2 related protein A1	Homo sapiens	39-44
17724464-4	2008	Bfl-1/Bak interaction is functional as Bfl-1 suppressed staurosporine (STS)-induced apoptosis in wild-type and Bax-deficient cells, but not in Bak-/- cells.	Staurosporine	56-69	BCL2 associated X, apoptosis regulator	Homo sapiens	111-114
17724464-4	2008	Bfl-1/Bak interaction is functional as Bfl-1 suppressed staurosporine (STS)-induced apoptosis in wild-type and Bax-deficient cells, but not in Bak-/- cells.	Staurosporine	71-74	BCL2 related protein A1	Homo sapiens	0-5
17724464-4	2008	Bfl-1/Bak interaction is functional as Bfl-1 suppressed staurosporine (STS)-induced apoptosis in wild-type and Bax-deficient cells, but not in Bak-/- cells.	Staurosporine	71-74	BCL2 antagonist/killer 1	Homo sapiens	6-9
17724464-4	2008	Bfl-1/Bak interaction is functional as Bfl-1 suppressed staurosporine (STS)-induced apoptosis in wild-type and Bax-deficient cells, but not in Bak-/- cells.	Staurosporine	71-74	BCL2 related protein A1	Homo sapiens	39-44
18177859-4	2008	Here we show that CRP1 is induced by growth-inhibitory signals, such as increased cellular density, and cytotoxic stress induced by UV radiation or staurosporine.	Staurosporine	148-161	cysteine-rich protein 1 (intestinal)	Mus musculus	18-22
18177859-6	2008	Following UV- and staurosporine-induced stresses, expression of CRP1 provides a survival advantage evidenced by decreased cellular death and increased cellular metabolic activity and attachment.	Staurosporine	18-31	cysteine-rich protein 1 (intestinal)	Mus musculus	64-68
18068114-5	2008	In mouse N2A neuroblastoma cells Nulp1 affected cell proliferation and sensitized cells towards death induced by staurosporine.	Staurosporine	113-126	transcription factor 25 (basic helix-loop-helix)	Mus musculus	33-38
18298916-10	2008	PLC inhibitor U73122, protein kinase C (PKC) inhibitor staurosporine (STS) and mitogen-activated ERK activating kinase (MEK) inhibitor PD98059 also inhibited the AngII-induced phosphorylation of PDGF-beta receptor.	Staurosporine	55-68	angiotensinogen	Rattus norvegicus	162-167
18298916-10	2008	PLC inhibitor U73122, protein kinase C (PKC) inhibitor staurosporine (STS) and mitogen-activated ERK activating kinase (MEK) inhibitor PD98059 also inhibited the AngII-induced phosphorylation of PDGF-beta receptor.	Staurosporine	70-73	angiotensinogen	Rattus norvegicus	162-167
18080861-8	2008	The activity prevented Akt dephosphorylation and degradation, after apoptosis induction by staurosporine and the production of reactive oxygen species after UV-B irradiation.	Staurosporine	91-104	AKT serine/threonine kinase 1	Homo sapiens	23-26
18047842-4	2008	ApoE knockdown increased staurosporine-induced caspase-3 activation by 78% without altering cell survival or apoptosis as assessed by TUNEL analysis and morphological changes.	Staurosporine	25-38	apolipoprotein E	Mus musculus	0-4
18047842-4	2008	ApoE knockdown increased staurosporine-induced caspase-3 activation by 78% without altering cell survival or apoptosis as assessed by TUNEL analysis and morphological changes.	Staurosporine	25-38	caspase 3	Mus musculus	47-56
18047842-6	2008	In these experiments, staurosporine-induced caspase-3 activation was increased by 49% in apoE null compared to wild type mBMDM and this was not associated with differences in TUNEL signal, annexin-V binding or DNA fragmentation.	Staurosporine	22-35	caspase 3	Mus musculus	44-53
18047842-6	2008	In these experiments, staurosporine-induced caspase-3 activation was increased by 49% in apoE null compared to wild type mBMDM and this was not associated with differences in TUNEL signal, annexin-V binding or DNA fragmentation.	Staurosporine	22-35	apolipoprotein E	Mus musculus	89-93
18059182-8	2008	Dominant negative PPM1H protected HeLa cells from cell death triggered by staurosporine or taxol.	Staurosporine	74-87	protein phosphatase, Mg2+/Mn2+ dependent 1H	Homo sapiens	18-23
17890287-7	2008	Staurosporine elicited apoptosis of oTr cells, which could be partially inhibited by LGALS15.	Staurosporine	0-13	galactoside-binding soluble lectin 13	Bos taurus	85-92
18082144-4	2008	Furthermore, we show three applications using the microarray: (1) detection of autophosphorylation activity of DBtagged human protein kinases and inhibition of their activity by staurosporine, (2) specific cleavage of DBtagged proteins by a virus protease and caspase 3, and (3) detection of a protein-protein interaction between the DBtagged UBE2N and UBE2v1.	Staurosporine	178-191	caspase 3	Homo sapiens	260-269
18082144-4	2008	Furthermore, we show three applications using the microarray: (1) detection of autophosphorylation activity of DBtagged human protein kinases and inhibition of their activity by staurosporine, (2) specific cleavage of DBtagged proteins by a virus protease and caspase 3, and (3) detection of a protein-protein interaction between the DBtagged UBE2N and UBE2v1.	Staurosporine	178-191	ubiquitin conjugating enzyme E2 N	Homo sapiens	343-348
18082144-4	2008	Furthermore, we show three applications using the microarray: (1) detection of autophosphorylation activity of DBtagged human protein kinases and inhibition of their activity by staurosporine, (2) specific cleavage of DBtagged proteins by a virus protease and caspase 3, and (3) detection of a protein-protein interaction between the DBtagged UBE2N and UBE2v1.	Staurosporine	178-191	ubiquitin conjugating enzyme E2 V1	Homo sapiens	353-359
17766334-7	2008	Expression of YFP-Bcl-x(L) or YFP-Bcl-x(L)-DeltaTM provided significant resistance to staurosporine-induced apoptosis.	Staurosporine	86-99	Bcl2-like 1	Rattus norvegicus	18-26
18206965-5	2008	Staurosporine or loss of cell adhesion enhanced FERM-dependent FAK nuclear accumulation.	Staurosporine	0-13	protein tyrosine kinase 2	Homo sapiens	63-66
18048062-9	2008	Glabridin also suppressed the elevated Bax protein and caspase-3 proenzyme and decreased bcl-2 induced by staurosporine in cultured rat cortical neurons, facilitating cell survival.	Staurosporine	106-119	BCL2, apoptosis regulator	Rattus norvegicus	89-94
17766334-7	2008	Expression of YFP-Bcl-x(L) or YFP-Bcl-x(L)-DeltaTM provided significant resistance to staurosporine-induced apoptosis.	Staurosporine	86-99	Bcl2-like 1	Rattus norvegicus	34-42
17932497-2	2008	We describe here that engagement of apoptotic processes by Fas triggering or by staurosporine stimulation leads to the caspase-dependent inactivation of the nuclear factor kappa B (NF-kappaB) pathway after cleavage of IKK1 (IkappaB kinase 1) and NEMO (NF-kappaB essential modulator), which are needed to transduce NF-kappaB activation signals.	Staurosporine	80-93	nuclear factor kappa B subunit 1	Homo sapiens	157-179
17932497-2	2008	We describe here that engagement of apoptotic processes by Fas triggering or by staurosporine stimulation leads to the caspase-dependent inactivation of the nuclear factor kappa B (NF-kappaB) pathway after cleavage of IKK1 (IkappaB kinase 1) and NEMO (NF-kappaB essential modulator), which are needed to transduce NF-kappaB activation signals.	Staurosporine	80-93	nuclear factor kappa B subunit 1	Homo sapiens	181-190
17932497-2	2008	We describe here that engagement of apoptotic processes by Fas triggering or by staurosporine stimulation leads to the caspase-dependent inactivation of the nuclear factor kappa B (NF-kappaB) pathway after cleavage of IKK1 (IkappaB kinase 1) and NEMO (NF-kappaB essential modulator), which are needed to transduce NF-kappaB activation signals.	Staurosporine	80-93	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	218-222
17932497-2	2008	We describe here that engagement of apoptotic processes by Fas triggering or by staurosporine stimulation leads to the caspase-dependent inactivation of the nuclear factor kappa B (NF-kappaB) pathway after cleavage of IKK1 (IkappaB kinase 1) and NEMO (NF-kappaB essential modulator), which are needed to transduce NF-kappaB activation signals.	Staurosporine	80-93	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	224-240
17932497-2	2008	We describe here that engagement of apoptotic processes by Fas triggering or by staurosporine stimulation leads to the caspase-dependent inactivation of the nuclear factor kappa B (NF-kappaB) pathway after cleavage of IKK1 (IkappaB kinase 1) and NEMO (NF-kappaB essential modulator), which are needed to transduce NF-kappaB activation signals.	Staurosporine	80-93	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	246-250
17932497-2	2008	We describe here that engagement of apoptotic processes by Fas triggering or by staurosporine stimulation leads to the caspase-dependent inactivation of the nuclear factor kappa B (NF-kappaB) pathway after cleavage of IKK1 (IkappaB kinase 1) and NEMO (NF-kappaB essential modulator), which are needed to transduce NF-kappaB activation signals.	Staurosporine	80-93	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	252-281
17932497-2	2008	We describe here that engagement of apoptotic processes by Fas triggering or by staurosporine stimulation leads to the caspase-dependent inactivation of the nuclear factor kappa B (NF-kappaB) pathway after cleavage of IKK1 (IkappaB kinase 1) and NEMO (NF-kappaB essential modulator), which are needed to transduce NF-kappaB activation signals.	Staurosporine	80-93	nuclear factor kappa B subunit 1	Homo sapiens	252-261
18769044-0	2008	DIDS attenuates staurosporine-induced cardiomyocyte apoptosis by PI3K/Akt signaling pathway: activation of eNOS/NO and inhibition of Bax translocation.	Staurosporine	16-29	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
18769044-0	2008	DIDS attenuates staurosporine-induced cardiomyocyte apoptosis by PI3K/Akt signaling pathway: activation of eNOS/NO and inhibition of Bax translocation.	Staurosporine	16-29	BCL2 associated X, apoptosis regulator	Rattus norvegicus	133-136
18769044-9	2008	CONCLUSION: DIDS protects cardiomyocytes against STS-induced apoptosis via activating PI3K/Akt signaling pathway, including increasing eNOS phosphorylation and the subsequent NO production and inhibiting Bax translocation.	Staurosporine	49-52	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
18769044-9	2008	CONCLUSION: DIDS protects cardiomyocytes against STS-induced apoptosis via activating PI3K/Akt signaling pathway, including increasing eNOS phosphorylation and the subsequent NO production and inhibiting Bax translocation.	Staurosporine	49-52	BCL2 associated X, apoptosis regulator	Rattus norvegicus	204-207
18336727-8	2008	The effects of the recombinant allergens on CD13-expression were dose- and time-dependent, were not observed in the absence of extracellular calcium, and were counteracted by preincubation of basophils with the PI3-kinase-targeting drugs staurosporin and LY294002.	Staurosporine	238-250	alanyl aminopeptidase, membrane	Homo sapiens	44-48
32689436-2	2008	A positive correlation between AtMCP1b expression and cell death was observed in the presence of staurosporine, a protein kinase inhibitor that induces programmed cell death.	Staurosporine	97-110	metacaspase 1	Arabidopsis thaliana	31-38
18336727-8	2008	The effects of the recombinant allergens on CD13-expression were dose- and time-dependent, were not observed in the absence of extracellular calcium, and were counteracted by preincubation of basophils with the PI3-kinase-targeting drugs staurosporin and LY294002.	Staurosporine	238-250	peptidase inhibitor 3	Homo sapiens	211-214
18097008-4	2008	Th2.R cells had a multifaceted, apoptosis-resistant phenotype, including: 1) reduced apoptosis after staurosporine addition, serum starvation, or CD3/CD28 costimulation; 2) reduced activation of caspases 3 and 9; and 3) increased anti-apoptotic Bcl-xL expression and reduced proapoptotic Bim and Bid expression.	Staurosporine	101-114	heart and neural crest derivatives expressed 2	Mus musculus	0-3
18097625-7	2008	Staurosporine, a protein kinase inhibitor, stimulated MMP-9 secretion by normal T lymphocytes, while the constitutively high levels of MMP-9 produced by tumor bearers" T cells were decreased by Genistein, a specific tyrosine kinase inhibitor, and Rottlerin, a PKC inhibitor.	Staurosporine	0-13	matrix metallopeptidase 9	Mus musculus	54-59
17559070-7	2008	The hypoxia-induced changes in MMP-9 and TIMP-1 were inhibited by staurosporine and bisindolylmaleimide, inhibitors of protein kinase C (PKC), but not by inhibitors of tyrosine phosphorylation and the mitogen-activated protein kinase pathway.	Staurosporine	66-79	matrix metallopeptidase 9	Homo sapiens	31-36
17559070-7	2008	The hypoxia-induced changes in MMP-9 and TIMP-1 were inhibited by staurosporine and bisindolylmaleimide, inhibitors of protein kinase C (PKC), but not by inhibitors of tyrosine phosphorylation and the mitogen-activated protein kinase pathway.	Staurosporine	66-79	TIMP metallopeptidase inhibitor 1	Homo sapiens	41-47
18367439-8	2008	Conversely, NSC-34 cell smn overexpression by adenoviral gene transfer decreased staurosporine-induced caspase-3 elevation and mitigated induced cell toxicity as assessed by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.	Staurosporine	81-94	survival motor neuron 1	Mus musculus	24-27
18043507-5	2008	Wortmannin and staurosporine effects on internalization of GLUT1 were not specific, supporting a basal constitutive GLUT1 membrane-recycling pathway between an intracellular pool and the cell surface in CIT3 cells, which targets most GLUT1 to the plasma membrane in GM.	Staurosporine	15-28	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	59-64
18043507-5	2008	Wortmannin and staurosporine effects on internalization of GLUT1 were not specific, supporting a basal constitutive GLUT1 membrane-recycling pathway between an intracellular pool and the cell surface in CIT3 cells, which targets most GLUT1 to the plasma membrane in GM.	Staurosporine	15-28	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	116-121
18043507-5	2008	Wortmannin and staurosporine effects on internalization of GLUT1 were not specific, supporting a basal constitutive GLUT1 membrane-recycling pathway between an intracellular pool and the cell surface in CIT3 cells, which targets most GLUT1 to the plasma membrane in GM.	Staurosporine	15-28	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	116-121
18367439-8	2008	Conversely, NSC-34 cell smn overexpression by adenoviral gene transfer decreased staurosporine-induced caspase-3 elevation and mitigated induced cell toxicity as assessed by 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.	Staurosporine	81-94	caspase 3	Mus musculus	103-112
18093317-10	2007	Additionally, Dkk3 displayed pro-survival properties by decreasing caspase activation and increasing viability in HEK293 cells exposed to staurosporine and H2O2.	Staurosporine	138-151	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	14-18
17983652-8	2008	The Ca(2+)-dependent protein kinase C (PKC) was also activated in EEC after calcitonin treatment, and the PKC inhibitors staurosporine and calphostin C could completely abolish calcitonin-induced augmentation of trophoblast expansion on EEC.	Staurosporine	121-134	calcitonin related polypeptide alpha	Homo sapiens	76-86
17983652-8	2008	The Ca(2+)-dependent protein kinase C (PKC) was also activated in EEC after calcitonin treatment, and the PKC inhibitors staurosporine and calphostin C could completely abolish calcitonin-induced augmentation of trophoblast expansion on EEC.	Staurosporine	121-134	calcitonin related polypeptide alpha	Homo sapiens	177-187
17928287-7	2007	The binding of TCF11/MafG to the iNOS promoter could be enhanced by phorbol 12-myristate 13-acetate and suppressed by the protein kinase C inhibitor staurosporine.	Staurosporine	149-162	MAF bZIP transcription factor G	Rattus norvegicus	21-25
17928287-7	2007	The binding of TCF11/MafG to the iNOS promoter could be enhanced by phorbol 12-myristate 13-acetate and suppressed by the protein kinase C inhibitor staurosporine.	Staurosporine	149-162	nitric oxide synthase 2	Rattus norvegicus	33-37
17928287-8	2007	Moreover, the induction of TCF11/MafG binding by TGF-beta and Smad6-short could be blocked by staurosporine, and the effect of TGF-beta was blocked by the selective protein kinase C inhibitor calphostin C. Consistent with the in vitro data, we found suppression of TCF11 coincident with iNOS up-regulation in a rat model of endotoxemia, and we observed a highly significant negative correlation between TCF11 and nitric oxide production.	Staurosporine	94-107	MAF bZIP transcription factor G	Rattus norvegicus	33-37
17928287-8	2007	Moreover, the induction of TCF11/MafG binding by TGF-beta and Smad6-short could be blocked by staurosporine, and the effect of TGF-beta was blocked by the selective protein kinase C inhibitor calphostin C. Consistent with the in vitro data, we found suppression of TCF11 coincident with iNOS up-regulation in a rat model of endotoxemia, and we observed a highly significant negative correlation between TCF11 and nitric oxide production.	Staurosporine	94-107	transforming growth factor, beta 1	Rattus norvegicus	49-57
17928287-8	2007	Moreover, the induction of TCF11/MafG binding by TGF-beta and Smad6-short could be blocked by staurosporine, and the effect of TGF-beta was blocked by the selective protein kinase C inhibitor calphostin C. Consistent with the in vitro data, we found suppression of TCF11 coincident with iNOS up-regulation in a rat model of endotoxemia, and we observed a highly significant negative correlation between TCF11 and nitric oxide production.	Staurosporine	94-107	SMAD family member 6	Rattus norvegicus	62-67
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	59-72	BCL2 like 1	Homo sapiens	181-187
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	59-72	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	250-255
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	59-72	BCL2 apoptosis regulator	Homo sapiens	271-276
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	59-72	BCL2 like 1	Homo sapiens	284-290
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	74-77	BCL2 apoptosis regulator	Homo sapiens	172-177
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	74-77	BCL2 like 1	Homo sapiens	181-187
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	74-77	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	250-255
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	74-77	BCL2 apoptosis regulator	Homo sapiens	271-276
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	74-77	BCL2 like 1	Homo sapiens	284-290
17997753-3	2007	METHOD OF STUDY: As the intracellular signal transduction pathway used by IFN-gamma in target cells is the Janus kinase (JAK)-signal transducer and transcription activator (STAT), here we analyzed in the mouse trophoblast the effect of IFN-gamma and staurosporine on mRNA and protein expressions of IFN-gamma signaling molecules correlating them with iNOS expression.	Staurosporine	250-263	interferon gamma	Mus musculus	74-83
17997753-3	2007	METHOD OF STUDY: As the intracellular signal transduction pathway used by IFN-gamma in target cells is the Janus kinase (JAK)-signal transducer and transcription activator (STAT), here we analyzed in the mouse trophoblast the effect of IFN-gamma and staurosporine on mRNA and protein expressions of IFN-gamma signaling molecules correlating them with iNOS expression.	Staurosporine	250-263	signal transducer and activator of transcription 1	Mus musculus	173-177
17997753-6	2007	These effects were abrogated when IFN-gamma receptor was blocked by staurosporine.	Staurosporine	68-81	interferon gamma	Mus musculus	34-43
18005068-8	2007	Finally, we showed that immunodepletion of FGF-2 or pharmacological blockade of FGF-2 receptor by SU5402 completely abolished staurosporine-treated cortex mitogenic activity on SVZ cultures but did not alter its activity on neuronal cell differentiation.	Staurosporine	126-139	fibroblast growth factor 2	Rattus norvegicus	43-48
17996851-6	2007	To a greater extent than the apoptotic stimulus, staurosporine, hyperosmotic stress activated caspase-3.	Staurosporine	49-62	caspase 3	Rattus norvegicus	94-103
18005068-8	2007	Finally, we showed that immunodepletion of FGF-2 or pharmacological blockade of FGF-2 receptor by SU5402 completely abolished staurosporine-treated cortex mitogenic activity on SVZ cultures but did not alter its activity on neuronal cell differentiation.	Staurosporine	126-139	fibroblast growth factor 2	Rattus norvegicus	80-85
17503524-8	2007	When cells attached to the Ti-grafted RGDS were challenged with staurosporine, an apoptogen, there was significant inhibition of apoptosis; in contrast, osteoblasts adherent to the Ti-grafted RGES were killed.	Staurosporine	64-77	ral guanine nucleotide dissociation stimulator	Mus musculus	38-42
17919561-10	2007	Carbachol-stimulated MAPK activity was inhibited by three PKC inhibitors, calphostin C, chelethyrine, and staurosporine.	Staurosporine	106-119	mitogen activated protein kinase 3	Rattus norvegicus	21-25
17883400-0	2007	Monoamine oxidase-A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells.	Staurosporine	62-75	monoamine oxidase A	Homo sapiens	0-19
17883400-3	2007	In this study, we describe the MAO-A isoform as functional in apoptosis induced by staurosporine (STS) in human dopaminergic neuroblastoma cells (SH-SY5Y).	Staurosporine	98-101	monoamine oxidase A	Homo sapiens	31-36
17883400-7	2007	STS treatment resulted in sustained activation of the mitogen-activated protein kinase pathway enzymes extracellular regulated kinase, c-jun terminal kinase and p38, and depletion of the anti-apoptotic protein Bcl-2.	Staurosporine	0-3	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	135-140
17883400-7	2007	STS treatment resulted in sustained activation of the mitogen-activated protein kinase pathway enzymes extracellular regulated kinase, c-jun terminal kinase and p38, and depletion of the anti-apoptotic protein Bcl-2.	Staurosporine	0-3	mitogen-activated protein kinase 14	Homo sapiens	161-164
17883400-7	2007	STS treatment resulted in sustained activation of the mitogen-activated protein kinase pathway enzymes extracellular regulated kinase, c-jun terminal kinase and p38, and depletion of the anti-apoptotic protein Bcl-2.	Staurosporine	0-3	BCL2 apoptosis regulator	Homo sapiens	210-215
17913816-10	2007	Further, NSm protein expression inhibited the staurosporine-induced activation of caspase-8 and -9, demonstrating that other viral proteins were dispensable for NSm"s function in inhibiting apoptosis.	Staurosporine	46-59	caspase 8	Homo sapiens	82-98
17923691-3	2007	Here we report that the protein kinase C (PKC) inhibitor and apoptotic inducer staurosporine switches the production of Bcl-x towards the x(S) mRNA isoform in 293 cells.	Staurosporine	79-92	BCL2 like 1	Homo sapiens	120-125
17923691-4	2007	The increase in Bcl-x(S) elicited by staurosporine likely involves signaling events that affect splicing decisions, because it requires active transcription and no new protein synthesis and is independent of caspase activation.	Staurosporine	37-50	BCL2 like 1	Homo sapiens	16-21
17923691-6	2007	Alternative splicing of the receptor tyrosine kinase gene Axl is similarly affected by staurosporine in 293 cells.	Staurosporine	87-100	AXL receptor tyrosine kinase	Homo sapiens	58-61
17923691-8	2007	Using minigenes, we show that an exonic region located upstream of the Bcl-x(S) 5" splice site is important to mediate the staurosporine shift in Bcl-x splicing.	Staurosporine	123-136	BCL2 like 1	Homo sapiens	71-76
17923691-8	2007	Using minigenes, we show that an exonic region located upstream of the Bcl-x(S) 5" splice site is important to mediate the staurosporine shift in Bcl-x splicing.	Staurosporine	123-136	BCL2 like 1	Homo sapiens	146-151
17923691-9	2007	When transplanted to other alternative splicing units, portions of this region confer splicing modulation and responsiveness to staurosporine, suggesting the existence of factors that couple splicing decisions with PKC signaling.	Staurosporine	128-141	proline rich transmembrane protein 2	Homo sapiens	215-218
18088187-7	2007	Chk1 phosphorylation was maintained only in the presence of staurosporine and UCN-01 in p53+/+ cells.	Staurosporine	60-73	checkpoint kinase 1	Homo sapiens	0-4
18088187-7	2007	Chk1 phosphorylation was maintained only in the presence of staurosporine and UCN-01 in p53+/+ cells.	Staurosporine	60-73	tumor protein p53	Homo sapiens	88-91
18088187-9	2007	The pathway of Chk1 phosphorylation --&gt; Cdc25A degradation --&gt; inhibition of cyclin B1/Cdk1 activity --&gt; G2 arrest is accordingly resistant to staurosporine and UCN-01 in p53+/+ cells.	Staurosporine	152-165	checkpoint kinase 1	Homo sapiens	15-19
18088187-9	2007	The pathway of Chk1 phosphorylation --&gt; Cdc25A degradation --&gt; inhibition of cyclin B1/Cdk1 activity --&gt; G2 arrest is accordingly resistant to staurosporine and UCN-01 in p53+/+ cells.	Staurosporine	152-165	cyclin B1	Homo sapiens	83-92
18088187-10	2007	Moreover, sustained phosphorylation of Chk1 in the presence of staurosporine and UCN-01 is strongly related to phosphorylation of p53.	Staurosporine	63-76	checkpoint kinase 1	Homo sapiens	39-43
18088187-10	2007	Moreover, sustained phosphorylation of Chk1 in the presence of staurosporine and UCN-01 is strongly related to phosphorylation of p53.	Staurosporine	63-76	tumor protein p53	Homo sapiens	130-133
18045496-8	2007	The function of HCCR-1 on mitochondrial membrane is to retard the intrinsic apoptosis induced by UVC and staurosporine, respectively.	Staurosporine	105-118	LETM1 domain containing 1	Homo sapiens	16-22
18045496-9	2007	CONCLUSION: Our experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction that can result in resisting the UVC or staurosporine-induced apoptosis and progressing in the tumor formation.	Staurosporine	207-220	LETM1 domain containing 1	Homo sapiens	124-130
18073527-0	2007	Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: role of Nur77 and Bcl-2.	Staurosporine	0-13	nuclear receptor subfamily 4 group A member 1	Homo sapiens	87-92
18073527-0	2007	Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: role of Nur77 and Bcl-2.	Staurosporine	0-13	BCL2 apoptosis regulator	Homo sapiens	97-102
18073527-4	2007	Here we demonstrate that the broad-acting kinase inhibitor staurosporine (STS) confers GC-sensitivity on GC-resistant T lymphoma cells expressing elevated levels of either Bcl-2 or Bcl-XL, but not on GC-resistant myelogenic leukemia cells expressing Mcl-1 in addition to Bcl-2 and/or Bcl-XL.	Staurosporine	59-72	BCL2 apoptosis regulator	Homo sapiens	172-177
17875645-2	2007	Both full-length type-I IP(3)R and a truncated construct corresponding to the caspase-3 cleaved "channel-only" fragment were able to support staurosporine (STS)-induced caspase-3 activation and cell death even when the IP(3)R construct harbored a mutation that inactivates the pore of the Ca(2+) channel (D2550A).	Staurosporine	141-154	caspase 3	Gallus gallus	78-87
17875645-2	2007	Both full-length type-I IP(3)R and a truncated construct corresponding to the caspase-3 cleaved "channel-only" fragment were able to support staurosporine (STS)-induced caspase-3 activation and cell death even when the IP(3)R construct harbored a mutation that inactivates the pore of the Ca(2+) channel (D2550A).	Staurosporine	141-154	caspase 3	Gallus gallus	169-178
17875645-2	2007	Both full-length type-I IP(3)R and a truncated construct corresponding to the caspase-3 cleaved "channel-only" fragment were able to support staurosporine (STS)-induced caspase-3 activation and cell death even when the IP(3)R construct harbored a mutation that inactivates the pore of the Ca(2+) channel (D2550A).	Staurosporine	156-159	caspase 3	Gallus gallus	78-87
17875645-2	2007	Both full-length type-I IP(3)R and a truncated construct corresponding to the caspase-3 cleaved "channel-only" fragment were able to support staurosporine (STS)-induced caspase-3 activation and cell death even when the IP(3)R construct harbored a mutation that inactivates the pore of the Ca(2+) channel (D2550A).	Staurosporine	156-159	caspase 3	Gallus gallus	169-178
17883400-3	2007	In this study, we describe the MAO-A isoform as functional in apoptosis induced by staurosporine (STS) in human dopaminergic neuroblastoma cells (SH-SY5Y).	Staurosporine	83-96	monoamine oxidase A	Homo sapiens	31-36
17549627-5	2007	We demonstrate that PRP-1 significantly reduced apoptosis of postnatal hippocampal cells induced by staurosporine.	Staurosporine	100-113	placental prolactin-related protein 1	Bos taurus	20-25
17726646-4	2007	Fusion of the p53 nuclear export signaling sequence MFRELNEALELK to NDelta19 (NDelta19NES) abolished its apoptosis promoting properties, while overexpression of NDelta19 significantly increased the susceptibility to apoptosis induction by the proteasome inhibitor PSI and by staurosporine.	Staurosporine	275-288	tumor protein p53	Homo sapiens	14-17
18020360-7	2007	This molecule was heat-stable up to 80 degrees C, while 30K protein lost its activity at temperatures higher than 60 degrees C. When apoptosis was induced by staurosporine in HeLa cells, SP2 protein suppressed nuclear fragmentation and apoptotic body formation.	Staurosporine	158-171	Sp2 transcription factor	Homo sapiens	187-190
17497674-0	2007	Glial cell line-derived neurotrophic factor protects astrocytes from staurosporine- and ischemia- induced apoptosis.	Staurosporine	69-82	glial cell derived neurotrophic factor	Homo sapiens	0-43
17497674-3	2007	We transfected mouse astrocytes in primary cultures with a human GDNF gene and found that their conditioned medium could not only support the growth and survival of cultured dopaminergic neurons but also protect astrocytes from staurosporine- and ischemia-induced apoptosis.	Staurosporine	228-241	glial cell derived neurotrophic factor	Homo sapiens	65-69
17904550-5	2007	We found that staurosporine-induced differentiation led to an upregulation of MAP2c, a MAP2 isoform expressed in developing neurons.	Staurosporine	14-27	microtubule-associated protein 2	Mus musculus	78-82
17549627-11	2007	Previously obtained data and results of the current studies suggested that the hypothalamic PRP-1 possibly represents an endogenous peptide whose primary functions are to regulate myelopoiesis and neuron survival as we provide evidence that PRP can differentially reduce both staurosporine- and doxorubicin-induced hippocampal and bone marrow cell apoptosis.	Staurosporine	276-289	placental prolactin-related protein 1	Bos taurus	92-97
17549627-11	2007	Previously obtained data and results of the current studies suggested that the hypothalamic PRP-1 possibly represents an endogenous peptide whose primary functions are to regulate myelopoiesis and neuron survival as we provide evidence that PRP can differentially reduce both staurosporine- and doxorubicin-induced hippocampal and bone marrow cell apoptosis.	Staurosporine	276-289	PRP@	Bos taurus	92-95
17690099-4	2007	Similarly, incubating intact cells with ascorbate plus TMPD to reduce intracellular cytochrome c strongly inhibited staurosporine-induced cell death, apoptosis, and caspase activation but not cytochrome c release, indicating that cytochrome c redox state can regulate caspase activation.	Staurosporine	116-129	cytochrome c, somatic	Homo sapiens	84-96
17952061-3	2007	Downregulation of AK2 attenuates etoposide- or staurosporine-induced apoptosis in human cells, but not that induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL) or Fas ligand (FasL).	Staurosporine	47-60	adenylate kinase 2	Homo sapiens	18-21
17686864-10	2007	Moreover, FPV039 prevented the activation of Bak and protected infected cells from apoptosis induced by staurosporine and virus infection.	Staurosporine	104-117	Bcl-2 protein	Fowlpox virus	10-16
17618736-0	2007	Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1.	Staurosporine	15-28	sphingomyelin phosphodiesterase 2	Homo sapiens	93-117
17618736-0	2007	Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1.	Staurosporine	15-28	caveolin 1	Homo sapiens	121-131
17618736-3	2007	In the paper, we demonstrated that caveolin-1 overexpression in Hs578T cells significantly reduced staurosporine-induced apoptosis and the levels of caveolin-1 expression positively correlated with the number of colonies and colony size in soft agar.	Staurosporine	99-112	caveolin 1	Homo sapiens	35-45
17726028-8	2007	Tyrosyl phosphorylation of wild type PAK1 decreases apoptosis induced by serum deprivation and staurosporine treatment and increases cell motility.	Staurosporine	95-108	p21 (RAC1) activated kinase 1	Homo sapiens	37-41
17974988-8	2007	We found that inhibition of the p38 mitogen-activated protein kinase pathway blocked bioluminescence induction by doxorubicin, paclitaxel, and staurosporine in CMV-driven luciferase-expressing cells.	Staurosporine	143-156	mitogen-activated protein kinase 14	Homo sapiens	32-35
17624593-10	2007	Finally, we observed that MAP kinases were activated upon staurosporine treatment and that at least activation of ERK was prevented when AVD was inhibited.	Staurosporine	58-71	mitogen-activated protein kinase 1	Homo sapiens	114-117
17707089-9	2007	Our results demonstrate that the staurosporine-induced death pathway bifurcates in caspase-compromised cells and commitment to apoptotic or necrotic phenotypes depends on cathepsin protease or Hsp90 chaperon activities.	Staurosporine	33-46	heat shock protein 90 alpha family class B member 1	Homo sapiens	193-198
17599827-9	2007	Staurosporine, a selective blocker of PKC, did not block the effect of paraoxon on Ca2+ action potential suppression and hyperexcitability induction.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	38-41
17340627-0	2007	Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell death.	Staurosporine	76-89	AKT serine/threonine kinase 1	Homo sapiens	30-33
17628013-2	2007	We found that specific c-Myc inhibition depleted cells of GSH by directly reducing the gene expression of both heavy and light subunits of the gamma-GCS enzyme and increased their susceptibility to antineoplastic drugs with different mechanisms of action, such as cisplatin (CDDP), staurosporine (STR), and 5-fluorouracil (5-FU).	Staurosporine	282-295	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	23-28
17628013-2	2007	We found that specific c-Myc inhibition depleted cells of GSH by directly reducing the gene expression of both heavy and light subunits of the gamma-GCS enzyme and increased their susceptibility to antineoplastic drugs with different mechanisms of action, such as cisplatin (CDDP), staurosporine (STR), and 5-fluorouracil (5-FU).	Staurosporine	282-295	glutamate-cysteine ligase catalytic subunit	Homo sapiens	143-152
17937911-2	2007	Here, we present the structure of the human ASK1 catalytic domain in complex with staurosporine.	Staurosporine	82-95	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	44-48
17898224-6	2007	Cells treated with staurosporine also induced caspase-dependent cleavage and redistribution of TDP-43 from its nuclear localization to cytoplasm.	Staurosporine	19-32	TAR DNA binding protein	Homo sapiens	95-101
17654655-6	2007	The digitonin assay and the commercially available kit gave comparable results, showing that staurosporine caused cytochrome c release in all phases of the cell cycle and clearly defining those cells that had lost DNA due to internucleosomal DNA fragmentation.	Staurosporine	93-106	cytochrome c, somatic	Homo sapiens	114-126
17340627-6	2007	Expression of active Akt targeted to mitochondria was found to be sufficient to significantly reduce staurosporine-induced activation of caspase-3 and caspase-9, the release of cytochrome c from mitochondria, and Bax oligomerization at mitochondria.	Staurosporine	101-114	AKT serine/threonine kinase 1	Homo sapiens	21-24
17340627-6	2007	Expression of active Akt targeted to mitochondria was found to be sufficient to significantly reduce staurosporine-induced activation of caspase-3 and caspase-9, the release of cytochrome c from mitochondria, and Bax oligomerization at mitochondria.	Staurosporine	101-114	caspase 3	Homo sapiens	137-146
17340627-6	2007	Expression of active Akt targeted to mitochondria was found to be sufficient to significantly reduce staurosporine-induced activation of caspase-3 and caspase-9, the release of cytochrome c from mitochondria, and Bax oligomerization at mitochondria.	Staurosporine	101-114	caspase 9	Homo sapiens	151-160
17340627-6	2007	Expression of active Akt targeted to mitochondria was found to be sufficient to significantly reduce staurosporine-induced activation of caspase-3 and caspase-9, the release of cytochrome c from mitochondria, and Bax oligomerization at mitochondria.	Staurosporine	101-114	cytochrome c, somatic	Homo sapiens	177-189
17340627-6	2007	Expression of active Akt targeted to mitochondria was found to be sufficient to significantly reduce staurosporine-induced activation of caspase-3 and caspase-9, the release of cytochrome c from mitochondria, and Bax oligomerization at mitochondria.	Staurosporine	101-114	BCL2 associated X, apoptosis regulator	Homo sapiens	213-216
17583675-10	2007	Further, the pretreatment of staurosporine abrogated ERK(1/2)/p38MAPK phosphorylation, suggesting that Hcy-induced ERK(1/2)/p38MAPK activation is associated with PKC activity.	Staurosporine	29-42	mitogen-activated protein kinase 3	Homo sapiens	53-60
17583675-10	2007	Further, the pretreatment of staurosporine abrogated ERK(1/2)/p38MAPK phosphorylation, suggesting that Hcy-induced ERK(1/2)/p38MAPK activation is associated with PKC activity.	Staurosporine	29-42	mitogen-activated protein kinase 3	Homo sapiens	115-122
17699779-10	2007	Further, RNA interference-mediated knockdown of ERalpha resulted in reduced Survivin expression and enhanced the propensity of MCF-7 cells to undergo apoptosis in response to staurosporine treatment, an effect that was blocked by exogenous expression of Survivin.	Staurosporine	175-188	estrogen receptor 1	Homo sapiens	48-55
17537491-1	2007	BACKGROUND AND OBJECTIVE: UCN-01 is a staurosporine analogue shown to abrogate the G2 checkpoint through inhibition of cyclin-dependent kinases.	Staurosporine	38-51	urocortin	Homo sapiens	26-29
17464323-3	2007	Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK.	Staurosporine	129-142	cyclin dependent kinase inhibitor 1C	Homo sapiens	31-34
17464323-3	2007	Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK.	Staurosporine	129-142	cyclin dependent kinase inhibitor 1C	Homo sapiens	35-39
17464323-3	2007	Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK.	Staurosporine	129-142	cyclin dependent kinase inhibitor 1C	Homo sapiens	193-197
17464323-3	2007	Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK.	Staurosporine	144-147	cyclin dependent kinase inhibitor 1C	Homo sapiens	31-34
17464323-3	2007	Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK.	Staurosporine	144-147	cyclin dependent kinase inhibitor 1C	Homo sapiens	35-39
17464323-3	2007	Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK.	Staurosporine	144-147	cyclin dependent kinase inhibitor 1C	Homo sapiens	189-192
17464323-3	2007	Here, we report that selective p57(Kip2) expression sensitizes cancer cells to apoptotic agents such as cisplatin, etoposide and staurosporine (STS) via a mechanism, which does not require p57(Kip2)-mediated inhibition of CDK.	Staurosporine	144-147	cyclin dependent kinase inhibitor 1C	Homo sapiens	193-197
17400382-2	2007	Our research shows that rat astrocyte exposure to 100 nM staurosporine for 3h caused apoptotic death accompanied by caspase-3, p38 mitogen-ed protein kinase (MAPK) and glycogen synthase kinase-3beta (GSK3beta) activation.	Staurosporine	57-70	mitogen activated protein kinase 14	Rattus norvegicus	127-130
17385009-3	2007	Six-hour exposure of human neuroblastoma SK-N-SH cell to a PKC activator phorbol 12-myristate 13-acetate (PMA) decreased the activity of NTE, and this effect was blocked by the PKC inhibitor staurosporine.	Staurosporine	191-204	patatin like phospholipase domain containing 6	Homo sapiens	137-140
17540506-8	2007	Intracellular blockade of protein kinase A by Rp-cAMP (10 microM) or staurosporine (50 nM) reduced NMDA currents and abolished CORT depression of NMDA currents.	Staurosporine	69-82	cortistatin	Homo sapiens	127-131
17537921-7	2007	High-dose, proapoptotic TGF-beta1 directly promotes the nuclear import of dendrin, and nuclear dendrin enhances both staurosporine- and TGF-beta1-mediated apoptosis.	Staurosporine	117-130	dendrin	Homo sapiens	95-102
17540411-8	2007	In cells expressing RGS5, the inhibitory effect of RGS5 on ET-1-induced Ca(2+) responses was enhanced by staurosporine.	Staurosporine	105-118	regulator of G protein signaling 5	Homo sapiens	20-24
17540411-8	2007	In cells expressing RGS5, the inhibitory effect of RGS5 on ET-1-induced Ca(2+) responses was enhanced by staurosporine.	Staurosporine	105-118	regulator of G protein signaling 5	Homo sapiens	51-55
17400382-2	2007	Our research shows that rat astrocyte exposure to 100 nM staurosporine for 3h caused apoptotic death accompanied by caspase-3, p38 mitogen-ed protein kinase (MAPK) and glycogen synthase kinase-3beta (GSK3beta) activation.	Staurosporine	57-70	caspase 3	Rattus norvegicus	116-125
17488721-8	2007	Surprisingly, Orf3-expressing cells were protected against staurosporine-induced cell death by preservation of mitochondrial potential and membrane integrity.	Staurosporine	59-72	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	14-18
17488721-9	2007	A small interfering RNA-mediated reduction in Orf3 and VDAC levels also made cells sensitive to staurosporine.	Staurosporine	96-109	ankyrin repeat, SAM and basic leucine zipper domain containing 1	Homo sapiens	46-50
17412810-11	2007	However, enhanced caspase 3 activation was observed in the presence of BFK upon staurosporine-induced apoptosis.	Staurosporine	80-93	caspase 3	Mus musculus	18-27
17412810-11	2007	However, enhanced caspase 3 activation was observed in the presence of BFK upon staurosporine-induced apoptosis.	Staurosporine	80-93	BCLl2-like 15	Mus musculus	71-74
17620436-7	2007	In contrast to other Bcl-x(L) inhibitors, combining gain-of-function Bcl-x(L) inhibitors with a standard inducer of apoptosis, staurosporine, enhances selective cytotoxicity toward Bcl-x(L)-overexpressing cells.	Staurosporine	127-140	BCL2 like 1	Homo sapiens	69-74
17620436-7	2007	In contrast to other Bcl-x(L) inhibitors, combining gain-of-function Bcl-x(L) inhibitors with a standard inducer of apoptosis, staurosporine, enhances selective cytotoxicity toward Bcl-x(L)-overexpressing cells.	Staurosporine	127-140	BCL2 like 1	Homo sapiens	69-74
17524524-4	2007	Wildtype (wt)-bFGF was shown to protect rat primary cultures of embryonic hippocampal neurons against damage caused by staurosporine and to reduce the infarct size in mice after focal cerebral ischemia.	Staurosporine	119-132	fibroblast growth factor 2	Rattus norvegicus	14-18
17901567-3	2007	Twenty-four hour incubation with staurosporine (1 microM) enhanced the caspase-3 activity, decreased mitochondrial membrane potential and increased the number of apoptotic cells as visualized by Hoechst staining.	Staurosporine	33-46	caspase 3	Homo sapiens	71-80
17901567-4	2007	1,25-Dihydroxyvitamin D3 and PRI-2191 attenuated the staurosporine-induced caspase-3 activity at 5, 50 and 500 nM, whereas PRI-1890 and PRI-1901 were active only at higher concentrations.	Staurosporine	53-66	caspase 3	Homo sapiens	75-84
17901567-7	2007	Further study revealed that a selective inhibitor of phosphatidylinositol 3-kinase (PI3-K), wortmannin, at concentration of 100 nM antagonized the effect of 1,25-dihydroxyvitamin D3 and PRI-2191 on staurosporine-induced caspase-3 activation.	Staurosporine	198-211	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	53-82
17382927-4	2007	Phorbol-12-myristate-13-acetate (a PKC activator), also abolished this t-BHP-induced reduction in EAAT3 activity, whereas staurosporine (a PKC inhibitor), significantly decreased EAAT3 activity.	Staurosporine	122-135	solute carrier family 1 member 1	Rattus norvegicus	179-184
17174496-4	2007	RESULTS: Clematis mandshurica prevented staurosporin-induced downregulation of several antiapoptotic bcl-2 family proteins Bcl-xL and Bcl-2, and staurosporin-induced upregulation of an apoptotic bcl-2 family protein Bax.	Staurosporine	40-52	BCL2, apoptosis regulator	Rattus norvegicus	101-106
17174496-4	2007	RESULTS: Clematis mandshurica prevented staurosporin-induced downregulation of several antiapoptotic bcl-2 family proteins Bcl-xL and Bcl-2, and staurosporin-induced upregulation of an apoptotic bcl-2 family protein Bax.	Staurosporine	40-52	Bcl2-like 1	Rattus norvegicus	123-129
17174496-4	2007	RESULTS: Clematis mandshurica prevented staurosporin-induced downregulation of several antiapoptotic bcl-2 family proteins Bcl-xL and Bcl-2, and staurosporin-induced upregulation of an apoptotic bcl-2 family protein Bax.	Staurosporine	40-52	BCL2, apoptosis regulator	Rattus norvegicus	134-139
17174496-4	2007	RESULTS: Clematis mandshurica prevented staurosporin-induced downregulation of several antiapoptotic bcl-2 family proteins Bcl-xL and Bcl-2, and staurosporin-induced upregulation of an apoptotic bcl-2 family protein Bax.	Staurosporine	40-52	BCL2, apoptosis regulator	Rattus norvegicus	195-200
17174496-4	2007	RESULTS: Clematis mandshurica prevented staurosporin-induced downregulation of several antiapoptotic bcl-2 family proteins Bcl-xL and Bcl-2, and staurosporin-induced upregulation of an apoptotic bcl-2 family protein Bax.	Staurosporine	40-52	BCL2 associated X, apoptosis regulator	Rattus norvegicus	216-219
17174496-8	2007	Immunoprecipitation assay elucidated that Clematis mandshurica prevented the staurosporin-induced reduction of the interactions between 14-3-3 with phospho-ser112-Bad and Bcl-xL to phospho-ser155-Bad.	Staurosporine	77-89	Bcl2-like 1	Rattus norvegicus	171-177
17229812-6	2007	Cytoplast NKCC1 activity was potentiated by the Ser/Thr protein phosphatase inhibitor calyculin A, partially inhibited by the protein kinase A inhibitor H89, and blocked by the broad protein kinase inhibitor staurosporine.	Staurosporine	208-221	solute carrier family 12, member 2	Mus musculus	10-15
17290286-6	2007	In addition, activity of protein phosphatase 2A (PP2A), which dephosphorylates p-CREB, significantly increased in young HDFs but not in senescent HDFs treated with H(2)O(2), staurosporine or thapsigargin.	Staurosporine	174-187	protein phosphatase 2 phosphatase activator	Homo sapiens	49-53
17167772-4	2007	OPA1(Delta58) did not influence mitochondrial morphology, but increased the sensitivity to staurosporine of fibroblasts.	Staurosporine	91-104	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	0-4
17167784-10	2007	Dopamine-induced p38 and p42/44 MAPK phosphorylation was blocked by SQ 22536, neomycin, and staurosporine.	Staurosporine	92-105	mitogen-activated protein kinase 14	Homo sapiens	17-20
17167784-10	2007	Dopamine-induced p38 and p42/44 MAPK phosphorylation was blocked by SQ 22536, neomycin, and staurosporine.	Staurosporine	92-105	cyclin dependent kinase 20	Homo sapiens	25-28
17167784-12	2007	In addition, dopamine significantly increased the level of NF-kappaB p65, which was prevented by either SQ 22536, neomycin, staurosporine, PD 98059, or SB 203580.	Staurosporine	124-137	RELA proto-oncogene, NF-kB subunit	Homo sapiens	69-72
17377587-0	2007	Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent.	Staurosporine	57-70	diablo IAP-binding mitochondrial protein	Homo sapiens	0-4
17377587-4	2007	Enforced expression of Apaf-1 rendered Raji cells sensitive to staurosporine as well as to the proteasome inhibitor, lactacystin.	Staurosporine	63-76	apoptotic peptidase activating factor 1	Homo sapiens	23-29
17331604-3	2007	GM-CSF inhibited staurosporine-induced cytotoxicity and apoptosis of N2a cells.	Staurosporine	17-30	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-6
17418451-0	2007	Staurosporine differentiation of NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells induces selectivity of NPFF activity towards opioid receptors.	Staurosporine	0-13	neuropeptide FF receptor 2	Homo sapiens	33-38
17418451-0	2007	Staurosporine differentiation of NPFF2 receptor-transfected SH-SY5Y neuroblastoma cells induces selectivity of NPFF activity towards opioid receptors.	Staurosporine	0-13	neuropeptide FF-amide peptide precursor	Homo sapiens	33-37
17375909-1	2007	A pyridocarbazole platinum complex, which matches the overall shape of the natural product staurosporine, binds with high affinity at the adenosine triphosphate binding site of glycogen synthase kinase 3 (GSK-3alpha).	Staurosporine	91-104	glycogen synthase kinase 3 alpha	Homo sapiens	205-215
17321601-3	2007	In this paper we investigated the effect of bovine alpha(1)-acid glycoprotein (boAGP) on spontaneous and staurosporine-induced apoptosis of blood derived monocytes purified using magnetic cell sorting techniques.	Staurosporine	105-118	alpha-1-acid glycoprotein	Bos taurus	51-77
17130845-8	2007	When caspase-9-deficient mouse embryonic fibroblasts (MEFs) were treated with staurosporine, WTS was proteolysed by activated endogenous Omi without induction of cell death.	Staurosporine	78-91	caspase 9	Mus musculus	5-14
17130845-8	2007	When caspase-9-deficient mouse embryonic fibroblasts (MEFs) were treated with staurosporine, WTS was proteolysed by activated endogenous Omi without induction of cell death.	Staurosporine	78-91	large tumor suppressor kinase 1	Homo sapiens	93-96
17400382-2	2007	Our research shows that rat astrocyte exposure to 100 nM staurosporine for 3h caused apoptotic death accompanied by caspase-3, p38 mitogen-ed protein kinase (MAPK) and glycogen synthase kinase-3beta (GSK3beta) activation.	Staurosporine	57-70	glycogen synthase kinase 3 beta	Rattus norvegicus	168-198
17400382-2	2007	Our research shows that rat astrocyte exposure to 100 nM staurosporine for 3h caused apoptotic death accompanied by caspase-3, p38 mitogen-ed protein kinase (MAPK) and glycogen synthase kinase-3beta (GSK3beta) activation.	Staurosporine	57-70	glycogen synthase kinase 3 beta	Rattus norvegicus	200-208
17400382-4	2007	CCPA also caused a dose- and time-dependent phosphorylation/activation of Akt, a downstream effector of cell survival promoting phosphatidylinositol 3-kinase (PI3K) pathway, which in turn led to inhibition of staurosporine-induced GSK3beta and p38 MAPK activity.	Staurosporine	209-222	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
17400382-4	2007	CCPA also caused a dose- and time-dependent phosphorylation/activation of Akt, a downstream effector of cell survival promoting phosphatidylinositol 3-kinase (PI3K) pathway, which in turn led to inhibition of staurosporine-induced GSK3beta and p38 MAPK activity.	Staurosporine	209-222	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	Rattus norvegicus	128-157
17276981-5	2007	We show by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and DNA fragmentation analyses that the overexpression of Aph-1a, Aph-1b, or Pen-2 drastically lowered staurosporine-induced cellular toxicity.	Staurosporine	184-197	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	139-145
17276981-5	2007	We show by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and DNA fragmentation analyses that the overexpression of Aph-1a, Aph-1b, or Pen-2 drastically lowered staurosporine-induced cellular toxicity.	Staurosporine	184-197	aph-1 homolog B, gamma-secretase subunit	Homo sapiens	147-153
17389524-2	2007	With the use of a transformed and undifferentiated retinal ganglion cell line, RGC-5, which does not express tPA, and by treating this cell line with staurosporine, which induces not only the differentiation of RGC-5 cells but also the expression of uPA and tPA in other neuronal cells, the authors sought to determine whether these proteases regulate the differentiation of RGC-5 cells and whether elevated levels of these proteases directly cause the death of RGC-5 cells.	Staurosporine	150-163	plasminogen activator, tissue	Mus musculus	109-112
17276981-5	2007	We show by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling and DNA fragmentation analyses that the overexpression of Aph-1a, Aph-1b, or Pen-2 drastically lowered staurosporine-induced cellular toxicity.	Staurosporine	184-197	presenilin enhancer, gamma-secretase subunit	Homo sapiens	158-163
17276981-6	2007	In support of an apoptosis rather than necrosis process, Aph-1 and Pen-2 also lower staurosporine- and etoposide-induced caspase-3 expression and diminished caspase-3 activity and poly(ADP-ribose) polymerase inactivation.	Staurosporine	84-97	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	57-62
17276981-6	2007	In support of an apoptosis rather than necrosis process, Aph-1 and Pen-2 also lower staurosporine- and etoposide-induced caspase-3 expression and diminished caspase-3 activity and poly(ADP-ribose) polymerase inactivation.	Staurosporine	84-97	presenilin enhancer, gamma-secretase subunit	Homo sapiens	67-72
17276981-6	2007	In support of an apoptosis rather than necrosis process, Aph-1 and Pen-2 also lower staurosporine- and etoposide-induced caspase-3 expression and diminished caspase-3 activity and poly(ADP-ribose) polymerase inactivation.	Staurosporine	84-97	caspase 3	Homo sapiens	121-130
17276981-8	2007	Furthermore, the Aph-1- and Pen-2-associated reduction of staurosporine-induced caspase-3 activation was fully abolished by p53 deficiency.	Staurosporine	58-71	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	17-22
17276981-8	2007	Furthermore, the Aph-1- and Pen-2-associated reduction of staurosporine-induced caspase-3 activation was fully abolished by p53 deficiency.	Staurosporine	58-71	presenilin enhancer, gamma-secretase subunit	Homo sapiens	28-33
17276981-8	2007	Furthermore, the Aph-1- and Pen-2-associated reduction of staurosporine-induced caspase-3 activation was fully abolished by p53 deficiency.	Staurosporine	58-71	caspase 3	Homo sapiens	80-89
17276981-8	2007	Furthermore, the Aph-1- and Pen-2-associated reduction of staurosporine-induced caspase-3 activation was fully abolished by p53 deficiency.	Staurosporine	58-71	tumor protein p53	Homo sapiens	124-127
17276981-11	2007	Furthermore, Aph-1- and Pen-2-associated protection against staurosporine-induced caspase-3 activation was not affected by the gamma-secretase inhibitors N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester and difluoromethylketone.	Staurosporine	60-73	aph-1 homolog A, gamma-secretase subunit	Homo sapiens	13-18
17276981-11	2007	Furthermore, Aph-1- and Pen-2-associated protection against staurosporine-induced caspase-3 activation was not affected by the gamma-secretase inhibitors N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester and difluoromethylketone.	Staurosporine	60-73	presenilin enhancer, gamma-secretase subunit	Homo sapiens	24-29
17276981-11	2007	Furthermore, Aph-1- and Pen-2-associated protection against staurosporine-induced caspase-3 activation was not affected by the gamma-secretase inhibitors N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester and difluoromethylketone.	Staurosporine	60-73	caspase 3	Homo sapiens	82-91
17255535-8	2007	Adenoviral overexpression of survivin conferred macrophages with sustained resistance to apoptosis after oxidized low-density lipoprotein, tumor necrosis factor-alpha, or staurosporine challenge.	Staurosporine	171-184	baculoviral IAP repeat-containing 5	Mus musculus	29-37
17389524-2	2007	With the use of a transformed and undifferentiated retinal ganglion cell line, RGC-5, which does not express tPA, and by treating this cell line with staurosporine, which induces not only the differentiation of RGC-5 cells but also the expression of uPA and tPA in other neuronal cells, the authors sought to determine whether these proteases regulate the differentiation of RGC-5 cells and whether elevated levels of these proteases directly cause the death of RGC-5 cells.	Staurosporine	150-163	plasminogen activator, urokinase	Mus musculus	250-253
17389524-2	2007	With the use of a transformed and undifferentiated retinal ganglion cell line, RGC-5, which does not express tPA, and by treating this cell line with staurosporine, which induces not only the differentiation of RGC-5 cells but also the expression of uPA and tPA in other neuronal cells, the authors sought to determine whether these proteases regulate the differentiation of RGC-5 cells and whether elevated levels of these proteases directly cause the death of RGC-5 cells.	Staurosporine	150-163	plasminogen activator, tissue	Mus musculus	258-261
17389524-10	2007	RGC-5 cells synthesized and secreted uPA and tPA into the conditioned medium, depending on staurosporine concentration and treatment time.	Staurosporine	91-104	plasminogen activator, urokinase	Mus musculus	37-40
17389524-10	2007	RGC-5 cells synthesized and secreted uPA and tPA into the conditioned medium, depending on staurosporine concentration and treatment time.	Staurosporine	91-104	plasminogen activator, tissue	Mus musculus	45-48
17389524-11	2007	At lower concentrations of staurosporine, differentiated RGC-5 cells had longer neurites and expressed lower levels of tPA and uPA.	Staurosporine	27-40	plasminogen activator, tissue	Mus musculus	119-122
17389524-11	2007	At lower concentrations of staurosporine, differentiated RGC-5 cells had longer neurites and expressed lower levels of tPA and uPA.	Staurosporine	27-40	plasminogen activator, urokinase	Mus musculus	127-130
17389524-12	2007	At higher concentrations of staurosporine, differentiated RGC-5 cells expressed higher levels of tPA and uPA, had smaller neurites, and most of them died.	Staurosporine	28-41	plasminogen activator, tissue	Mus musculus	97-100
17389524-12	2007	At higher concentrations of staurosporine, differentiated RGC-5 cells expressed higher levels of tPA and uPA, had smaller neurites, and most of them died.	Staurosporine	28-41	plasminogen activator, urokinase	Mus musculus	105-108
17389524-13	2007	In contrast, when RGC-5 cells were treated with staurosporine along with inhibitors specific to tPA and uPA, proteolytic activities of both PAs were significantly reduced.	Staurosporine	48-61	plasminogen activator, tissue	Mus musculus	96-99
17389524-13	2007	In contrast, when RGC-5 cells were treated with staurosporine along with inhibitors specific to tPA and uPA, proteolytic activities of both PAs were significantly reduced.	Staurosporine	48-61	plasminogen activator, urokinase	Mus musculus	104-107
17382384-10	2007	While hCG alone had no significant effect on endothelial cell apoptosis, the combination of VEGF-A and hCG protected HPMVEC from staurosporine-induced apoptosis.	Staurosporine	129-142	vascular endothelial growth factor A	Homo sapiens	92-98
17382384-10	2007	While hCG alone had no significant effect on endothelial cell apoptosis, the combination of VEGF-A and hCG protected HPMVEC from staurosporine-induced apoptosis.	Staurosporine	129-142	hypertrichosis 2 (generalised, congenital)	Homo sapiens	103-106
17394485-8	2007	Finally, in response to Fas receptor activation or staurosporine treatment the levels of beta-actin or alpha-tubulin remained unaltered, whereas several Golgi proteins, p115 and golgin-160, underwent caspase-mediated cleavage.	Staurosporine	51-64	POTE ankyrin domain family member F	Homo sapiens	89-99
17394485-8	2007	Finally, in response to Fas receptor activation or staurosporine treatment the levels of beta-actin or alpha-tubulin remained unaltered, whereas several Golgi proteins, p115 and golgin-160, underwent caspase-mediated cleavage.	Staurosporine	51-64	golgin A3	Homo sapiens	178-188
17305717-5	2007	In addition, SB225002, a G-protein-coupled receptor antagonist, and staurosporine, a serine-threonine kinase inhibitor, partially inhibited TGF-beta1-mediated induction of NGF.	Staurosporine	68-81	transforming growth factor beta 1	Homo sapiens	140-149
17264076-9	2007	The inhibitors ADP and staurosporine were both found to be competitive with ATP and non-competitive with S1, indicating binding of ATP and S1 to BTK is either random or ordered with ATP binding first.	Staurosporine	23-36	Bruton tyrosine kinase	Homo sapiens	145-148
17195091-4	2007	We show that Bcl-2 but not caspase inhibition prevented staurosporine-induced intracellular acidification.	Staurosporine	56-69	BCL2 apoptosis regulator	Homo sapiens	13-18
17045782-3	2007	Here we show that Epo prevents staurosporine-induced apoptosis of differentiated human neuroblastoma SH-SY5Y cells, and activates the STAT5, AKT and MAPK signaling pathways.	Staurosporine	31-44	erythropoietin	Homo sapiens	18-21
17003101-6	2007	Inhibition of PKC by staurosporine attenuated nicotine-induced ERK1/2 phosphorylation and COX-2 expression.	Staurosporine	21-34	proline rich transmembrane protein 2	Homo sapiens	14-17
17003101-6	2007	Inhibition of PKC by staurosporine attenuated nicotine-induced ERK1/2 phosphorylation and COX-2 expression.	Staurosporine	21-34	mitogen-activated protein kinase 3	Homo sapiens	63-69
17003101-6	2007	Inhibition of PKC by staurosporine attenuated nicotine-induced ERK1/2 phosphorylation and COX-2 expression.	Staurosporine	21-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	90-95
17464351-0	2007	Staurosporine inhibition of zipper-interacting protein kinase contractile effects in gastrointestinal smooth muscle.	Staurosporine	0-13	death associated protein kinase 3	Homo sapiens	28-61
17464351-6	2007	Staurosporine was the most effective ZIPK inhibitor, with a Ki value calculated to be 2.6 +/- 0.3 micromol/L.	Staurosporine	0-13	death associated protein kinase 3	Homo sapiens	37-41
17305717-5	2007	In addition, SB225002, a G-protein-coupled receptor antagonist, and staurosporine, a serine-threonine kinase inhibitor, partially inhibited TGF-beta1-mediated induction of NGF.	Staurosporine	68-81	nerve growth factor	Homo sapiens	172-175
17305717-6	2007	Phospho-p38 MAPK was suppressed by SB225002, whereas phospho-JNK was inhibited by staurosporine.	Staurosporine	82-95	mitogen-activated protein kinase 8	Homo sapiens	61-64
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	interleukin 1 alpha	Homo sapiens	58-67
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	mitogen-activated protein kinase 3	Homo sapiens	95-101
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	mitogen-activated protein kinase 1	Homo sapiens	103-106
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	mitogen-activated protein kinase 8	Homo sapiens	112-115
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	interleukin 1 alpha	Homo sapiens	58-67
17251521-7	2007	IL-1alpha(PKC), and PKC inhibitor staurosporine inhibited IL-1alpha-induced phosphorylation of ERK1/2, p38, and JNK, and decreased IL-1alpha-induced COX-2 mRNA expression.	Staurosporine	34-47	prostaglandin-endoperoxide synthase 2	Homo sapiens	149-154
17210223-5	2007	We show in this report that staurosporine, a kinase inhibitor, induces the expression of the StAR gene in Y1 adrenocortical cells, possibly a result of an increase in the population of dephospho-TORC.	Staurosporine	28-41	steroidogenic acute regulatory protein	Homo sapiens	93-97
17169462-3	2007	We have recently demonstrated an implication of phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a tumor suppressor, in ROS generation and neuronal apoptosis induced by staurosporine.	Staurosporine	186-199	phosphatase and tensin homolog	Homo sapiens	107-111
17191140-1	2007	The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate.	Staurosporine	148-161	5'-nucleotidase, cytosolic II	Mus musculus	11-14
17191140-1	2007	The cyclic GMP analog 8-bromo-cyclic GMP (8-Br-cGMP) protects differentiated murine oligodendrocytes (OLs) from caspase-mediated death initiated by staurosporine, thapsigargin or kainate.	Staurosporine	148-161	5'-nucleotidase, cytosolic II	Mus musculus	37-40
17080327-0	2007	Fusiogenic endogenous-retroviral syncytin-1 exerts anti-apoptotic functions in staurosporine-challenged CHO cells.	Staurosporine	79-92	endogenous retrovirus group W member 1, envelope	Homo sapiens	33-43
17141276-10	2007	The high glucose-induced phosphorylation of Akt was blocked by bisindolymaleimide I, H-7, staurosporine (protein kinase C [PKC] inhibitors), vitamin C and catalase (antioxidants).	Staurosporine	90-103	AKT serine/threonine kinase 1	Homo sapiens	44-47
17121821-0	2007	The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.	Staurosporine	115-128	tumor protein p53	Homo sapiens	101-104
17121821-0	2007	The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.	Staurosporine	115-128	caspase 3	Homo sapiens	137-146
17121821-7	2007	We show that C1 potentiates staurosporine-induced caspase-3 activation through a p53-dependent mechanism.	Staurosporine	28-41	caspase 3	Homo sapiens	50-59
17121821-7	2007	We show that C1 potentiates staurosporine-induced caspase-3 activation through a p53-dependent mechanism.	Staurosporine	28-41	tumor protein p53	Homo sapiens	81-84
17088059-0	2007	Simplified staurosporine analogs as potent JAK3 inhibitors.	Staurosporine	11-24	Janus kinase 3	Homo sapiens	43-47
17088059-2	2007	The modification led to a new series of simplified staurosporine analogs, which exhibited significant inhibitory activity against Janus kinase 3 (JAK3).	Staurosporine	51-64	Janus kinase 3	Homo sapiens	130-144
17088059-2	2007	The modification led to a new series of simplified staurosporine analogs, which exhibited significant inhibitory activity against Janus kinase 3 (JAK3).	Staurosporine	51-64	Janus kinase 3	Homo sapiens	146-150
17038561-0	2007	Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin.	Staurosporine	39-52	prohibitin 1	Rattus norvegicus	129-139
17038561-3	2007	In the present study, we examined the role of prohibitin in mediating staurosporine (STS) and serum withdrawal induced apoptosis in undifferentiated rat granulosa cells.	Staurosporine	70-83	prohibitin 1	Rattus norvegicus	46-56
17038561-3	2007	In the present study, we examined the role of prohibitin in mediating staurosporine (STS) and serum withdrawal induced apoptosis in undifferentiated rat granulosa cells.	Staurosporine	85-88	prohibitin 1	Rattus norvegicus	46-56
17123514-1	2007	We demonstrate that global induction of apoptosis in primary bovine lens epithelial (LEC) or fibroblastic mouse NIH-3T3 cells by staurosporine, puromycin, cycloheximide, or etoposide is accompanied by a decrease in coupling by gap junctions.	Staurosporine	129-142	laryngotracheo esophageal cleft	Mus musculus	85-88
17123514-7	2007	In contrast, microinjection of staurosporine led to a rapid induction of apoptosis of the injected and a number of adjacent cells suggesting spreading of staurosporine most probably through gap junction pores held open by dephosphorylation of connexin-43 as verified by immunoblotting and staining using a phospho-serine368-specific anti-connexin-43 antibody.	Staurosporine	31-44	gap junction protein, alpha 1	Mus musculus	243-254
17123514-7	2007	In contrast, microinjection of staurosporine led to a rapid induction of apoptosis of the injected and a number of adjacent cells suggesting spreading of staurosporine most probably through gap junction pores held open by dephosphorylation of connexin-43 as verified by immunoblotting and staining using a phospho-serine368-specific anti-connexin-43 antibody.	Staurosporine	31-44	gap junction protein, alpha 1	Mus musculus	338-349
17123514-7	2007	In contrast, microinjection of staurosporine led to a rapid induction of apoptosis of the injected and a number of adjacent cells suggesting spreading of staurosporine most probably through gap junction pores held open by dephosphorylation of connexin-43 as verified by immunoblotting and staining using a phospho-serine368-specific anti-connexin-43 antibody.	Staurosporine	154-167	gap junction protein, alpha 1	Mus musculus	243-254
17123514-7	2007	In contrast, microinjection of staurosporine led to a rapid induction of apoptosis of the injected and a number of adjacent cells suggesting spreading of staurosporine most probably through gap junction pores held open by dephosphorylation of connexin-43 as verified by immunoblotting and staining using a phospho-serine368-specific anti-connexin-43 antibody.	Staurosporine	154-167	gap junction protein, alpha 1	Mus musculus	338-349
16968671-6	2007	Staurosporine activated apoptotic pathways (i.e. caspase-3 and caspase-9) increasing reactive oxygen species in myoblasts and, to a minor extent, in myotubes.	Staurosporine	0-13	caspase 3	Homo sapiens	49-58
16968671-6	2007	Staurosporine activated apoptotic pathways (i.e. caspase-3 and caspase-9) increasing reactive oxygen species in myoblasts and, to a minor extent, in myotubes.	Staurosporine	0-13	caspase 9	Homo sapiens	63-72
16968671-8	2007	Moreover, expression of uncoupling protein-3 in myotubes did not affect reactive oxygen species production, although it produced a slight sensitization for staurosporine-induced apoptosis.	Staurosporine	156-169	uncoupling protein 3	Homo sapiens	24-44
16906418-6	2007	RESULTS: HSP27 overexpression induced cellular resistance to heat shock at 45 degrees C for 1 h as well as against several cytotoxic agents, including cisplatin, staurosporin and H(2)O(2).	Staurosporine	162-174	heat shock protein family B (small) member 1	Homo sapiens	9-14
17227437-9	2007	Inhibition of protein kinase C activation with staurosporin prevented the effect of iron chelation on DAT function, suggesting that in vitro iron chelation affects DAT primarily through the effects on trafficking rather than on synthesis.	Staurosporine	47-59	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	102-105
17075901-3	2007	Staurosporine-induced cytochrome c release, caspase-3 activation, and production of reactive oxygen species (ROS) were significantly attenuated in S1 cells as compared to V cells and reduced by antioxidants, trolox and GSH-ethyl ester (GSH-EE).	Staurosporine	0-13	cytochrome c, somatic	Homo sapiens	22-34
17075901-3	2007	Staurosporine-induced cytochrome c release, caspase-3 activation, and production of reactive oxygen species (ROS) were significantly attenuated in S1 cells as compared to V cells and reduced by antioxidants, trolox and GSH-ethyl ester (GSH-EE).	Staurosporine	0-13	caspase 3	Homo sapiens	44-53
17075901-4	2007	Staurosporine-induced the release of Mcl-1 from mitochondria that formed a complex with Bim.	Staurosporine	0-13	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	37-42
17075901-4	2007	Staurosporine-induced the release of Mcl-1 from mitochondria that formed a complex with Bim.	Staurosporine	0-13	BCL2 like 11	Homo sapiens	88-91
17075901-5	2007	Mcl-1 was then cleaved to a shortened form in a caspase-3 dependent manner; its release was attenuated far more in S1 than in V cells after staurosporine treatment.	Staurosporine	140-153	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	0-5
17075901-5	2007	Mcl-1 was then cleaved to a shortened form in a caspase-3 dependent manner; its release was attenuated far more in S1 than in V cells after staurosporine treatment.	Staurosporine	140-153	caspase 3	Homo sapiens	48-57
17075901-6	2007	Finally, the staurosporine-induced decrease in mitochondrial membrane potential (Deltapsi(m)) was correlated with the time of mitochondrial Mcl-1 release; the loss of Deltapsi(m) was attenuated significantly in S1 cells as compared to that in V cells.	Staurosporine	13-26	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	140-145
17496430-0	2007	Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line.	Staurosporine	32-45	RB transcriptional corepressor 1	Homo sapiens	0-14
17496430-3	2007	RESULTS: The Rb-defective SF-539 cell line was resistant to staurosporine compared with cell lines expressing intact Rb.	Staurosporine	60-73	RB transcriptional corepressor 1	Homo sapiens	13-15
17496430-6	2007	CONCLUSIONS: These results imply that enforced Rb expression protects cells from genomic instability induced by staurosporine regardless of its upstream molecular effects.	Staurosporine	112-125	RB transcriptional corepressor 1	Homo sapiens	47-49
17327903-13	2006	Moreover, the phosphorylation of ERK induced by sevoflurane was significantly decreased by the treatment of PKC inhibitor (staurosporine) and MEK inhibitor (PD98059).	Staurosporine	123-136	Eph receptor B1	Rattus norvegicus	33-36
17191119-1	2007	MAGI-1, a member of the MAGUK family of proteins, is shown to be rapidly cleaved during Fas-induced apoptosis in mouse 3T3 A31 cells, and in UV irradiation- and staurosporine-induced apoptosis in HaCaT cells.	Staurosporine	161-174	membrane associated guanylate kinase, WW and PDZ domain containing 1	Mus musculus	0-6
17244733-7	2007	Treatment with protein kinase C (PKC) inhibitors staurosporine, bismaleimide I and bismaleimide X led to dose-dependent increases of both isotonic and hypotonic volumes (P&lt;0.05).	Staurosporine	49-62	proline rich transmembrane protein 2	Homo sapiens	15-31
17244733-7	2007	Treatment with protein kinase C (PKC) inhibitors staurosporine, bismaleimide I and bismaleimide X led to dose-dependent increases of both isotonic and hypotonic volumes (P&lt;0.05).	Staurosporine	49-62	proline rich transmembrane protein 2	Homo sapiens	33-36
17327903-13	2006	Moreover, the phosphorylation of ERK induced by sevoflurane was significantly decreased by the treatment of PKC inhibitor (staurosporine) and MEK inhibitor (PD98059).	Staurosporine	123-136	protein kinase C, gamma	Rattus norvegicus	108-111
16455194-6	2006	Treatment of cells with SB202190 (a specific inhibitor of p38), staurosporine (a wide-spectrum inhibitor of PKC) or rottlerin (a specific inhibitor of PKCdelta) all augmented ARE activation by tBHQ.	Staurosporine	64-77	protein kinase C delta	Homo sapiens	108-111
16823772-5	2006	In addition, the EGF-induced stimulation of [3H]-thymidine incorporation was prevented by staurosporine, H-7, or bisindolylmaleimide I (protein kinase C inhibitors), suggesting a role of PKC.	Staurosporine	90-103	epidermal growth factor	Gallus gallus	17-20
16901471-0	2006	Apoptosis mediated by p53 in rat neural AF5 cells following treatment with hydrogen peroxide and staurosporine.	Staurosporine	97-110	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	22-25
16514420-6	2006	In contrast, NPC death induced by staurosporine, a broad kinase inhibitor, is regulated by p53 in the absence of macromolecular synthesis.	Staurosporine	34-47	tumor protein p53	Homo sapiens	91-94
17018634-1	2006	Previously, we reported that breast cancer cells with retinoblastoma (pRb) pathway-defective checkpoints can be specifically targeted with chemotherapeutic agents, following staurosporine-mediated reversible growth inhibition in normal cells.	Staurosporine	174-187	RB transcriptional corepressor 1	Homo sapiens	70-73
17018634-3	2006	Normal human mammary epithelial and immortalized cells with intact pRb treated with low concentrations of staurosporine arrested in the G(1) phase of the cell cycle, whereas pRb-defective cells showed no response.	Staurosporine	106-119	RB transcriptional corepressor 1	Homo sapiens	67-70
17018634-5	2006	In pRb(+) cells, but not in Rb(-) cells, low concentrations of staurosporine also resulted in a significant decrease in cyclin-dependent kinase 4 (CDK4) expression and activity.	Staurosporine	63-76	RB transcriptional corepressor 1	Homo sapiens	3-6
17018634-5	2006	In pRb(+) cells, but not in Rb(-) cells, low concentrations of staurosporine also resulted in a significant decrease in cyclin-dependent kinase 4 (CDK4) expression and activity.	Staurosporine	63-76	cyclin dependent kinase 4	Homo sapiens	120-145
17018634-5	2006	In pRb(+) cells, but not in Rb(-) cells, low concentrations of staurosporine also resulted in a significant decrease in cyclin-dependent kinase 4 (CDK4) expression and activity.	Staurosporine	63-76	cyclin dependent kinase 4	Homo sapiens	147-151
17018634-8	2006	Additionally, CDK4 expression was also inhibited in response to staurosporine only in Rb(+/+) MEFs.	Staurosporine	64-77	cyclin dependent kinase 4	Homo sapiens	14-18
17018634-10	2006	Collectively, our data suggest that treatment of cells with nanomolar concentrations of staurosporine resulted in down-regulation of CDK4, which ultimately leads to G(1) arrest in normal human mammary epithelial and immortalized cells with an intact pRb pathway, but not in pRb-null/defective cells.	Staurosporine	88-101	cyclin dependent kinase 4	Homo sapiens	133-137
17018634-10	2006	Collectively, our data suggest that treatment of cells with nanomolar concentrations of staurosporine resulted in down-regulation of CDK4, which ultimately leads to G(1) arrest in normal human mammary epithelial and immortalized cells with an intact pRb pathway, but not in pRb-null/defective cells.	Staurosporine	88-101	RB transcriptional corepressor 1	Homo sapiens	250-253
17018634-10	2006	Collectively, our data suggest that treatment of cells with nanomolar concentrations of staurosporine resulted in down-regulation of CDK4, which ultimately leads to G(1) arrest in normal human mammary epithelial and immortalized cells with an intact pRb pathway, but not in pRb-null/defective cells.	Staurosporine	88-101	RB transcriptional corepressor 1	Homo sapiens	274-277
17032165-4	2006	IL-18 reduces NK cell self-destruction during NK-targeted cell killing, and in the presence of staurosporin, a potent apoptotic inducer, IL-18 reduces caspase-3 activity.	Staurosporine	95-107	interleukin 18	Homo sapiens	137-142
17032165-4	2006	IL-18 reduces NK cell self-destruction during NK-targeted cell killing, and in the presence of staurosporin, a potent apoptotic inducer, IL-18 reduces caspase-3 activity.	Staurosporine	95-107	caspase 3	Homo sapiens	151-160
16836654-8	2006	The activation of mGluR5 completely protected OPCs and substantially reduced staurosporine-induced apoptosis in OLs.	Staurosporine	77-90	glutamate receptor, ionotropic, kainate 1	Mus musculus	18-24
17013088-8	2006	Particularly, the release of mitochondrial cytochrome c was increased in response to staurosporine.	Staurosporine	85-98	cytochrome c, somatic	Homo sapiens	43-55
17049431-0	2006	Intracellular replication of Edwardsiella tarda in murine macrophage is dependent on the type III secretion system and induces an up-regulation of anti-apoptotic NF-kappaB target genes protecting the macrophage from staurosporine-induced apoptosis.	Staurosporine	216-229	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	162-171
17161373-2	2006	Here, we report the crystal structures of the phosphorylated human IRAK-4 kinase domain in complex with a potent inhibitor and with staurosporine to 2.0 and 2.2 A, respectively.	Staurosporine	132-145	interleukin 1 receptor associated kinase 4	Homo sapiens	67-73
17007817-7	2006	Staurosporine, a PKC inhibitor, and parthenolide, a NF-kappaB inhibitor, significantly reduced the CTT-dependent antiapoptotic effect.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	17-20
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	Staurosporine	76-89	MAPK associated protein 1	Homo sapiens	61-66
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	Staurosporine	76-89	caspase 3	Homo sapiens	98-107
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	Staurosporine	76-89	poly(ADP-ribose) polymerase 1	Homo sapiens	164-194
17093075-7	2006	Moreover, in cultures, the PN donor 3-morpholinosydnonimine (SIN-1) blocked staurosporine-induced caspase-3 activation and its downstream effects including PARP-1 [poly-(ADP-ribose) polymerase-1] cleavage and phosphotidylserine inversion, suggesting that peroxynitrite can inhibit caspase-3-mediated apoptosis.	Staurosporine	76-89	caspase 3	Homo sapiens	281-290
16760259-7	2006	The inhibitory effects of both cytokines on the NHE3 promoter were completely blocked by the broad-range kinase inhibitor staurosporine and the selective protein kinase A (PKA) inhibitor 8-bromoadenosine-3",5"-cyclic monophosphorothioate, Rp-isomer.	Staurosporine	122-135	solute carrier family 9 member A3	Homo sapiens	48-52
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Staurosporine	288-300	protein kinase C alpha	Homo sapiens	194-202
17013757-5	2006	Interestingly, the apoptotic events such as DNA ladders formation and activation of the caspase 3 cascade were significantly blocked by TPA addition in the presence of membrane translocation of PKCalpha, and TPA-induced protection was reduced by adding the PKC inhibitors, GF-109203X and staurosporin.	Staurosporine	288-300	protein kinase C alpha	Homo sapiens	194-197
16715208-1	2006	Staurosporin, a specific inhibitor of PKC, is widely used in studies of signal transduction pathways.	Staurosporine	0-12	protein kinase C delta	Homo sapiens	38-41
16715208-6	2006	NAC, which inhibits the generation of ROS, suppresses the staurosporin-induced neurite outgrowth in HN33 cells.	Staurosporine	58-70	synuclein alpha	Homo sapiens	0-3
16971513-5	2006	In addition, apoptosis of HeLa cells induced by staurosporine or serum-depletion was alleviated by the PICT-1 knockdown in the similar PTEN-dependent manner.	Staurosporine	48-61	NOP53 ribosome biogenesis factor	Homo sapiens	103-109
16971513-5	2006	In addition, apoptosis of HeLa cells induced by staurosporine or serum-depletion was alleviated by the PICT-1 knockdown in the similar PTEN-dependent manner.	Staurosporine	48-61	phosphatase and tensin homolog	Homo sapiens	135-139
16949056-2	2006	In the present study, we evaluated effects of 17beta-estradiol on pro-inflammatory cytokine- and staurosporine-mediated activation of caspase-3 and LDH-release in primary neuronal/glial cell cultures of mouse hippocampal and neocortical cells at different stages of their development in vitro.	Staurosporine	97-110	caspase 3	Mus musculus	134-159
16950206-0	2006	Dividing roles of prion protein in staurosporine-mediated apoptosis.	Staurosporine	35-48	prion protein	Mus musculus	18-31
16950206-4	2006	Emerging evidence suggests that PrPC plays a protective role against cellular stresses including apoptosis induced by various pro-apoptotic agents such as Bax and staurosporine (STS), however, other reports showed overexpression of PrPC enhances STS-mediated apoptosis.	Staurosporine	163-176	prion protein	Mus musculus	32-36
16950206-4	2006	Emerging evidence suggests that PrPC plays a protective role against cellular stresses including apoptosis induced by various pro-apoptotic agents such as Bax and staurosporine (STS), however, other reports showed overexpression of PrPC enhances STS-mediated apoptosis.	Staurosporine	163-176	prion protein	Mus musculus	232-236
16950206-4	2006	Emerging evidence suggests that PrPC plays a protective role against cellular stresses including apoptosis induced by various pro-apoptotic agents such as Bax and staurosporine (STS), however, other reports showed overexpression of PrPC enhances STS-mediated apoptosis.	Staurosporine	178-181	prion protein	Mus musculus	32-36
16721813-3	2006	Here DNA mismatch repair (MMR)-proficient human colon cancer cells (DLD-1+Ch2; hMSH6+) treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) undergo rapid cell death, which is significantly abolished by staurosporine (PKC inhibitor) or antioxidant, compared with the paired MMR-deficient (DLD-1; hMSH6-) cells.	Staurosporine	205-218	mutS homolog 6	Homo sapiens	79-84
16857185-0	2006	Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells.	Staurosporine	32-45	heat shock protein family H (Hsp110) member 1	Homo sapiens	0-6
16857185-0	2006	Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells.	Staurosporine	32-45	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
16930545-5	2006	PKC antagonist staurosporine completely reversed the effect of Ang II and phorbol ester.	Staurosporine	15-28	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	63-69
16934753-3	2006	The up-regulation of RGS2 mRNA was abrogated by genistein, a protein tyrosine kinase inhibitor (PTK), and by broad-spectrum protein kinase C (PKC) inhibitors (staurosporine and GF109203X).	Staurosporine	159-172	regulator of G-protein signaling 2	Rattus norvegicus	21-25
16934753-6	2006	In addition, isoproterenol also markedly stimulated RGS2 mRNA in rat primary astrocytes, which were sensitive to SB203580 and staurosporine.	Staurosporine	126-139	regulator of G-protein signaling 2	Rattus norvegicus	52-56
16782691-7	2006	In addition, the EGF-induced decrease in GLUT2 protein expression was inhibited by staurosporine, H-7, or bisindolylmaleimide I (PKC inhibitors), PD-98059 (a MEK inhibitor), SB-203580 (a p38 MAPK inhibitor), and SP-600125 (a JNK inhibitor), suggesting a role of both PKC and MAPKs (p44/42 MAPK, p38 MAPK, and JNK).	Staurosporine	83-96	solute carrier family 2 member 2	Gallus gallus	41-46
16901471-2	2006	This study examined p53 function in producing programmed cell death in propagating AF5 neural cells after exposure to hydrogen peroxide (H2O2) and the kinase inhibitor staurosporine (STSP).	Staurosporine	168-181	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	20-23
16901471-2	2006	This study examined p53 function in producing programmed cell death in propagating AF5 neural cells after exposure to hydrogen peroxide (H2O2) and the kinase inhibitor staurosporine (STSP).	Staurosporine	183-187	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	20-23
16912318-5	2006	Sense expression of the BAT3 peptide, which appears to reversibly interfere with BAT3 function by a dominant negative mechanism, resulted in decreased synthesis of viral DNA and proteins early after ASFV infection, altered transcription of apoptosis-related genes as determined by cDNA microarray analysis, and increased cellular sensitivity to staurosporine-induced apoptosis.	Staurosporine	345-358	BAG cochaperone 6	Homo sapiens	24-28
16870622-9	2006	In addition, cells overexpressing GCP60 were more sensitive to apoptosis induced by staurosporine, suggesting that nuclear-localized golgin-160-(140-311) might promote cell survival.	Staurosporine	84-97	acyl-CoA binding domain containing 3	Homo sapiens	34-39
16870622-9	2006	In addition, cells overexpressing GCP60 were more sensitive to apoptosis induced by staurosporine, suggesting that nuclear-localized golgin-160-(140-311) might promote cell survival.	Staurosporine	84-97	golgin A3	Homo sapiens	133-143
16806170-3	2006	We have previously shown that keratinocyte migration induced by EGF or staurosporine is dependent on the activity of glycogen synthase kinase-3 (GSK-3).	Staurosporine	71-84	glycogen synthase kinase 3 beta	Mus musculus	117-143
16806170-3	2006	We have previously shown that keratinocyte migration induced by EGF or staurosporine is dependent on the activity of glycogen synthase kinase-3 (GSK-3).	Staurosporine	71-84	glycogen synthase kinase 3 beta	Mus musculus	145-150
16806170-4	2006	In the present study, we show that keratinocyte migration induced by TGF-beta1, KGF, EGF, TGF-alpha and staurosporine depends on EGFR signaling, involves autocrine HB-EGF expression and is potently blocked by GSK-3 inhibitors SB-415286 and LiCl.	Staurosporine	104-117	epidermal growth factor receptor	Mus musculus	129-133
16806170-4	2006	In the present study, we show that keratinocyte migration induced by TGF-beta1, KGF, EGF, TGF-alpha and staurosporine depends on EGFR signaling, involves autocrine HB-EGF expression and is potently blocked by GSK-3 inhibitors SB-415286 and LiCl.	Staurosporine	104-117	heparin-binding EGF-like growth factor	Mus musculus	164-170
16806170-4	2006	In the present study, we show that keratinocyte migration induced by TGF-beta1, KGF, EGF, TGF-alpha and staurosporine depends on EGFR signaling, involves autocrine HB-EGF expression and is potently blocked by GSK-3 inhibitors SB-415286 and LiCl.	Staurosporine	104-117	glycogen synthase kinase 3 beta	Mus musculus	209-214
16570272-2	2006	Recently (Hemstrom et al., Exp Cell Res 2005;305:200-13) we showed that apoptosis of U1810 NSCLC cells induced by the staurosporine analog PKC 412 correlated with inhibition of Akt and ERK1/2, suggesting the involvement of these kinases in cell survival.	Staurosporine	118-131	AKT serine/threonine kinase 1	Homo sapiens	177-180
16570272-2	2006	Recently (Hemstrom et al., Exp Cell Res 2005;305:200-13) we showed that apoptosis of U1810 NSCLC cells induced by the staurosporine analog PKC 412 correlated with inhibition of Akt and ERK1/2, suggesting the involvement of these kinases in cell survival.	Staurosporine	118-131	mitogen-activated protein kinase 3	Homo sapiens	185-191
16615138-7	2006	Transfer of Hsp27 using a cationic lipid inhibited staurosporine (SP)-induced apoptotic cell death by 53% in a human lens epithelial cell line (HLE B-3).	Staurosporine	51-64	heat shock protein family B (small) member 1	Homo sapiens	12-17
16615138-7	2006	Transfer of Hsp27 using a cationic lipid inhibited staurosporine (SP)-induced apoptotic cell death by 53% in a human lens epithelial cell line (HLE B-3).	Staurosporine	66-68	heat shock protein family B (small) member 1	Homo sapiens	12-17
16615138-9	2006	SP-induced reactive oxygen species in HLE-B3 cells was significantly lower in cells transferred with MGO-modified Hsp27 when compared to native Hsp27.	Staurosporine	0-2	heat shock protein family B (small) member 1	Homo sapiens	114-119
16615138-9	2006	SP-induced reactive oxygen species in HLE-B3 cells was significantly lower in cells transferred with MGO-modified Hsp27 when compared to native Hsp27.	Staurosporine	0-2	heat shock protein family B (small) member 1	Homo sapiens	144-149
16912318-5	2006	Sense expression of the BAT3 peptide, which appears to reversibly interfere with BAT3 function by a dominant negative mechanism, resulted in decreased synthesis of viral DNA and proteins early after ASFV infection, altered transcription of apoptosis-related genes as determined by cDNA microarray analysis, and increased cellular sensitivity to staurosporine-induced apoptosis.	Staurosporine	345-358	BAG cochaperone 6	Homo sapiens	81-85
16572399-6	2006	In contrast, staurosporine-induced apoptosis was c-Myc-independent, confirming a functional apoptotic pathway in c-myc null cells.	Staurosporine	13-26	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	49-54
16680484-9	2006	Staurosporine [protein kinase C (PKC) inhibitor] impaired the effect of ANG II.	Staurosporine	0-13	angiotensinogen	Rattus norvegicus	72-78
16552723-10	2006	Staurosporine inhibited the CBN-induced increase in Cx43 content, suggesting a role for kinases in the signaling pathway.	Staurosporine	0-13	gap junction protein alpha 1	Bos taurus	52-56
16728389-0	2006	Calcium-independent phospholipase A2 localizes in and protects mitochondria during apoptotic induction by staurosporine.	Staurosporine	106-119	phospholipase A2 group IB	Rattus norvegicus	20-36
16728389-5	2006	Here we investigate whether group VIA Ca2+-independent PLA2 (iPLA2) plays a role in the protection of mitochondrial function from damage caused by mitochondrially generated ROS during apoptotic induction by staurosporine (STS).	Staurosporine	207-220	phospholipase A2 group IB	Rattus norvegicus	55-59
16728389-5	2006	Here we investigate whether group VIA Ca2+-independent PLA2 (iPLA2) plays a role in the protection of mitochondrial function from damage caused by mitochondrially generated ROS during apoptotic induction by staurosporine (STS).	Staurosporine	207-220	phospholipase A2 group VI	Rattus norvegicus	61-66
16728389-5	2006	Here we investigate whether group VIA Ca2+-independent PLA2 (iPLA2) plays a role in the protection of mitochondrial function from damage caused by mitochondrially generated ROS during apoptotic induction by staurosporine (STS).	Staurosporine	222-225	phospholipase A2 group IB	Rattus norvegicus	55-59
16728389-5	2006	Here we investigate whether group VIA Ca2+-independent PLA2 (iPLA2) plays a role in the protection of mitochondrial function from damage caused by mitochondrially generated ROS during apoptotic induction by staurosporine (STS).	Staurosporine	222-225	phospholipase A2 group VI	Rattus norvegicus	61-66
16782058-0	2006	Structure of human Fyn kinase domain complexed with staurosporine.	Staurosporine	52-65	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	19-22
16782058-4	2006	Here, we solved the crystal structure of the human Fyn kinase domain complexed with staurosporine, a potent kinase inhibitor, at 2.8 A resolution.	Staurosporine	84-97	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	51-54
16782058-5	2006	Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes.	Staurosporine	0-13	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-50
16782058-5	2006	Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes.	Staurosporine	0-13	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	81-84
16782058-5	2006	Staurosporine binds to the ATP-binding site of Fyn in a similar manner as in the Lck- and Csk-complexes.	Staurosporine	0-13	C-terminal Src kinase	Homo sapiens	90-93
16278065-6	2006	LPS-stimulated cPLA2 phosphorylation was inhibited by PD98059, GF109203X, and staurosporine, indicating the regulation by p42/p44 MAPK and PKC.	Staurosporine	78-91	phospholipase A2 group IVA	Canis lupus familiaris	15-20
16278065-6	2006	LPS-stimulated cPLA2 phosphorylation was inhibited by PD98059, GF109203X, and staurosporine, indicating the regulation by p42/p44 MAPK and PKC.	Staurosporine	78-91	mitogen-activated protein kinase 1	Canis lupus familiaris	130-134
16820941-6	2006	The effect of regucalcin in decreasing cellular protein content was significantly inhibited in the presence of various kinase inhibitors including staurosporine (10(-7) M), dibucaine (10(-6) M), PD98059 (10(-8) M), or wortmannin (10(-8) M).	Staurosporine	147-160	regucalcin	Mus musculus	14-24
17003475-5	2006	Primary pulmonary endothelial cells internalized human A1AT, which co-localized with and inhibited staurosporine-induced caspase-3 activation.	Staurosporine	99-112	serpin family A member 1	Homo sapiens	55-59
17003475-5	2006	Primary pulmonary endothelial cells internalized human A1AT, which co-localized with and inhibited staurosporine-induced caspase-3 activation.	Staurosporine	99-112	caspase 3	Homo sapiens	121-130
16673398-3	2006	Overexpression of Galpha(s-L) to a level twice that of the vector-transfected cells did not directly affect cell viability but significantly increased the sensitivity to induction of cell death by serum deprivation and other apoptotic stimuli, including staurosporine, H(2)O(2), and tunicamycin.	Staurosporine	254-267	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	18-28
16780893-7	2006	Moreover, it inhibits the cleavage of procaspase-3 mediated by proapoptotic member Bax or apoptosis inductor staurosporine.	Staurosporine	109-122	caspase 3	Homo sapiens	38-50
16709574-4	2006	Phosphorylation of Bax by JNK and p38 kinase activated after treatment with staurosporine, H(2)O(2), etoposide, and UV light was demonstrated by the shift in the pI value of Bax on two-dimensional gels and confirmed by metabolic labeling with inorganic [(32)P]phosphate in HepG2 cells.	Staurosporine	76-89	BCL2 associated X, apoptosis regulator	Homo sapiens	19-22
16709574-4	2006	Phosphorylation of Bax by JNK and p38 kinase activated after treatment with staurosporine, H(2)O(2), etoposide, and UV light was demonstrated by the shift in the pI value of Bax on two-dimensional gels and confirmed by metabolic labeling with inorganic [(32)P]phosphate in HepG2 cells.	Staurosporine	76-89	mitogen-activated protein kinase 8	Homo sapiens	26-29
16709574-4	2006	Phosphorylation of Bax by JNK and p38 kinase activated after treatment with staurosporine, H(2)O(2), etoposide, and UV light was demonstrated by the shift in the pI value of Bax on two-dimensional gels and confirmed by metabolic labeling with inorganic [(32)P]phosphate in HepG2 cells.	Staurosporine	76-89	mitogen-activated protein kinase 14	Homo sapiens	34-37
16709574-4	2006	Phosphorylation of Bax by JNK and p38 kinase activated after treatment with staurosporine, H(2)O(2), etoposide, and UV light was demonstrated by the shift in the pI value of Bax on two-dimensional gels and confirmed by metabolic labeling with inorganic [(32)P]phosphate in HepG2 cells.	Staurosporine	76-89	BCL2 associated X, apoptosis regulator	Homo sapiens	174-177
16709574-8	2006	Confocal microscopy of various Bax mutants showed differential rates of mitochondrial translocation of Bax before and after staurosporine treatment.	Staurosporine	124-137	BCL2 associated X, apoptosis regulator	Homo sapiens	31-34
16709574-8	2006	Confocal microscopy of various Bax mutants showed differential rates of mitochondrial translocation of Bax before and after staurosporine treatment.	Staurosporine	124-137	BCL2 associated X, apoptosis regulator	Homo sapiens	103-106
16735514-5	2006	The shedding of CD46 was initiated with staurosporine and UVB.	Staurosporine	40-53	CD46 molecule	Homo sapiens	16-20
16735514-6	2006	Exposure of cell cultures to either UVB or staurosporine resulted in changes of cell morphology and detachment of cells from their matrices within 8-24 h. During this process CD46 was released both in apoptotic vesicles (vCD46) and proteolytically (sCD46) into the medium.	Staurosporine	43-56	CD46 molecule	Homo sapiens	175-179
16787641-5	2006	Up-regulation of caspase-3 protein was evident in manganese-treated PC12 cells and was moderate in cisplatin-, rotenone- and A23187-treated cells but was not observed in serum deprivation-, anisomycin-, camptothecin-, cycloheximide- or staurosporine-treated cells in which all treatments induced extensive DNA fragmentation.	Staurosporine	236-249	caspase 3	Rattus norvegicus	17-26
16678346-0	2006	Enhanced ERK dependent CREB activation reduces apoptosis in staurosporine-treated human neuroblastoma SK-N-BE(2)C cells.	Staurosporine	60-73	mitogen-activated protein kinase 1	Homo sapiens	9-12
16678346-0	2006	Enhanced ERK dependent CREB activation reduces apoptosis in staurosporine-treated human neuroblastoma SK-N-BE(2)C cells.	Staurosporine	60-73	cAMP responsive element binding protein 1	Homo sapiens	23-27
16572399-6	2006	In contrast, staurosporine-induced apoptosis was c-Myc-independent, confirming a functional apoptotic pathway in c-myc null cells.	Staurosporine	13-26	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	113-118
16670179-11	2006	Mutant alsin induced neuronal death itself and also significantly enhanced the apoptogenic effect of NMDA and staurosporine.	Staurosporine	110-123	alsin Rho guanine nucleotide exchange factor ALS2	Homo sapiens	7-12
16532035-4	2006	Transforming growth factor alpha protected both species of astrocytes from staurosporine-induced apoptosis.	Staurosporine	75-88	tumor necrosis factor	Homo sapiens	0-32
16551274-5	2006	The expression of TRPC1 induced by stable transfection of IEC-6 cells with the wild-type TRPC1 gene (IEC-TRPC1 cells) increased Ca2+ influx after Ca2+ store depletion and repressed NF-kappaB transactivation, which was associated with an increase in susceptibility to apoptosis induced by exposure to TNFalpha (tumour necrosis factor-alpha) plus CHX (cycloheximide) (TNF-alpha/CHX), or STS (staurosporine).	Staurosporine	390-403	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	18-23
16551274-5	2006	The expression of TRPC1 induced by stable transfection of IEC-6 cells with the wild-type TRPC1 gene (IEC-TRPC1 cells) increased Ca2+ influx after Ca2+ store depletion and repressed NF-kappaB transactivation, which was associated with an increase in susceptibility to apoptosis induced by exposure to TNFalpha (tumour necrosis factor-alpha) plus CHX (cycloheximide) (TNF-alpha/CHX), or STS (staurosporine).	Staurosporine	390-403	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	89-94
16551274-5	2006	The expression of TRPC1 induced by stable transfection of IEC-6 cells with the wild-type TRPC1 gene (IEC-TRPC1 cells) increased Ca2+ influx after Ca2+ store depletion and repressed NF-kappaB transactivation, which was associated with an increase in susceptibility to apoptosis induced by exposure to TNFalpha (tumour necrosis factor-alpha) plus CHX (cycloheximide) (TNF-alpha/CHX), or STS (staurosporine).	Staurosporine	390-403	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	101-110
16632474-4	2006	In contrast, capn4(-/-) MEFs were more susceptible to staurosporine (STS) and tumor necrosis factor alpha-induced cell death, which provided evidence for anti-apoptotic signaling roles for calpain.	Staurosporine	54-67	calpain, small subunit 1	Mus musculus	13-18
16239929-2	2006	Such cells treated with staurosporine (STS) exhibited translocation to the mitochondria and activation of the proapoptotic signalling molecule Bax but failed to release Smac/DIABLO from these organelles, judged by both confocal microscopy and Western blotting.	Staurosporine	24-37	BCL2 associated X, apoptosis regulator	Homo sapiens	143-146
16786153-5	2006	Furthermore, an evident upregulation of PAR-1 in cultured primary astrocytes also occurred following exposure to lipopolysaccharide (LPS) (a well-known inductor of glial cell activation) whereas other neurotoxic agents (such as staurosporine, hydrogen peroxide and sodium azide), which are known to induce cell death, were unable to determine any PAR-1 variation.	Staurosporine	228-241	coagulation factor II (thrombin) receptor	Rattus norvegicus	40-45
16533807-10	2006	Moreover, we demonstrate that inhibition of okadaic acid or staurosporine-sensitive pathways in AP-2alpha overexpressing breast cancer cells resulted in AP-2alpha-dependent apoptosis induction.	Staurosporine	60-73	transcription factor AP-2 alpha	Homo sapiens	96-105
16533807-10	2006	Moreover, we demonstrate that inhibition of okadaic acid or staurosporine-sensitive pathways in AP-2alpha overexpressing breast cancer cells resulted in AP-2alpha-dependent apoptosis induction.	Staurosporine	60-73	transcription factor AP-2 alpha	Homo sapiens	153-162
16777606-5	2006	Furthermore, caspase-6-resistant mutant htt mice are protected against neurotoxicity induced by multiple stressors including NMDA, quinolinic acid (QA), and staurosporine.	Staurosporine	157-170	caspase 6	Mus musculus	13-22
16777606-5	2006	Furthermore, caspase-6-resistant mutant htt mice are protected against neurotoxicity induced by multiple stressors including NMDA, quinolinic acid (QA), and staurosporine.	Staurosporine	157-170	huntingtin	Mus musculus	40-43
16761096-0	2006	Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.	Staurosporine	72-85	TAO kinase 2	Homo sapiens	31-35
16761096-6	2006	Here we report the crystal structure of active TAO2 kinase domain in complex with staurosporine, a broad-range protein kinase inhibitor that inhibits TAO2 with an IC50 of 3 mM.	Staurosporine	82-95	TAO kinase 2	Homo sapiens	47-51
16761096-6	2006	Here we report the crystal structure of active TAO2 kinase domain in complex with staurosporine, a broad-range protein kinase inhibitor that inhibits TAO2 with an IC50 of 3 mM.	Staurosporine	82-95	TAO kinase 2	Homo sapiens	150-154
16817901-8	2006	The inactivation of kinase cascades by 10 nm staurosporine in LKB1-positive HEK293 cells also induced unregulated, constitutively activated, CRE activity.	Staurosporine	45-58	serine/threonine kinase 11	Homo sapiens	62-66
16817901-9	2006	Treatment with staurosporine completely inhibited SIK kinase activity without any significant effect on the phosphorylation level at the LKB1-phosphorylatable site in SIK or the activity of AMPK, another target of LKB1.	Staurosporine	15-28	salt inducible kinase 1	Homo sapiens	50-53
16817901-9	2006	Treatment with staurosporine completely inhibited SIK kinase activity without any significant effect on the phosphorylation level at the LKB1-phosphorylatable site in SIK or the activity of AMPK, another target of LKB1.	Staurosporine	15-28	serine/threonine kinase 11	Homo sapiens	214-218
16817901-10	2006	Constitutive activation of CREB in LKB1-defective cells or in staurosporine-treated cells was not accompanied by CREB phosphorylation at Ser133.	Staurosporine	62-75	cAMP responsive element binding protein 1	Homo sapiens	27-31
16397898-5	2006	We found that Neuro 2A cells exposed to ethanol accumulated considerably less PS in response to the DHA enrichment and were less effective at phosphorylating Akt and suppressing caspase-3 activity under serum-starved or staurosporine-treated conditions.	Staurosporine	220-233	caspase 3	Mus musculus	178-187
16761096-7	2006	The structure reveals that staurosporine occupies the position where the adenosine of ATP binds in TAO2, and the binding of the inhibitor mimics many features of ATP binding.	Staurosporine	27-40	TAO kinase 2	Homo sapiens	99-103
16761096-9	2006	Staurosporine induces conformational changes in TAO2 residues that surround the inhibitor molecule, but causes very limited global changes in the kinase.	Staurosporine	0-13	TAO kinase 2	Homo sapiens	48-52
16761096-10	2006	The structure provides atomic details for TAO2-staurosporine interactions, and explains the relatively low potency of staurosporine against TAO2.	Staurosporine	47-60	TAO kinase 2	Homo sapiens	42-46
16761096-10	2006	The structure provides atomic details for TAO2-staurosporine interactions, and explains the relatively low potency of staurosporine against TAO2.	Staurosporine	118-131	TAO kinase 2	Homo sapiens	42-46
16761096-10	2006	The structure provides atomic details for TAO2-staurosporine interactions, and explains the relatively low potency of staurosporine against TAO2.	Staurosporine	118-131	TAO kinase 2	Homo sapiens	140-144
16195740-3	2006	Exposure of eNOS-transfected COS-7 cells and bovine aortic endothelial cells to staurosporine resulted in significant loss of 135-kDa eNOS protein and activity, and appearance of a 60-kDa eNOS fragment; effects were inhibited by the general caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp[OMe]-fluoromethyl ketone (zVAD-fmk).	Staurosporine	80-93	nitric oxide synthase 3	Bos taurus	12-16
16195740-3	2006	Exposure of eNOS-transfected COS-7 cells and bovine aortic endothelial cells to staurosporine resulted in significant loss of 135-kDa eNOS protein and activity, and appearance of a 60-kDa eNOS fragment; effects were inhibited by the general caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp[OMe]-fluoromethyl ketone (zVAD-fmk).	Staurosporine	80-93	nitric oxide synthase 3	Bos taurus	134-138
16195740-3	2006	Exposure of eNOS-transfected COS-7 cells and bovine aortic endothelial cells to staurosporine resulted in significant loss of 135-kDa eNOS protein and activity, and appearance of a 60-kDa eNOS fragment; effects were inhibited by the general caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp[OMe]-fluoromethyl ketone (zVAD-fmk).	Staurosporine	80-93	nitric oxide synthase 3	Bos taurus	134-138
16195740-4	2006	In eNOS-transfected COS-7 cells, staurosporine-induced activation of caspase-3 and poly(ADP-ribose) polymerase (PARP) cleavage coincided with increased eNOS degradation and decreased activity.	Staurosporine	33-46	nitric oxide synthase 3	Bos taurus	3-7
16195740-4	2006	In eNOS-transfected COS-7 cells, staurosporine-induced activation of caspase-3 and poly(ADP-ribose) polymerase (PARP) cleavage coincided with increased eNOS degradation and decreased activity.	Staurosporine	33-46	nitric oxide synthase 3	Bos taurus	152-156
16699130-2	2006	In this study, the authors describe a multiplexed assay for caspase 3 activation, nuclear condensation, and cell viability in a neuronal precursor cell line Ntera-2, injured with staurosporine and etoposide.	Staurosporine	179-192	caspase 3	Homo sapiens	60-69
16412381-5	2006	Inhibitors of mitogen activated kinase (PD 98059), phosphatidyl-3-inositol-kinase (LY 294002), and protein kinase C (staurosporine) diminished the IGF-I effect suggesting the involvement of signal transduction.	Staurosporine	117-130	insulin like growth factor 1	Homo sapiens	147-152
16523241-5	2006	In addition, senescent cells whose FAK expression was downregulated by siRNA showed the increased level of apoptosis by staurosporine treatment via caspase-3 activation but not by hydrogen peroxide treatment.	Staurosporine	120-133	protein tyrosine kinase 2	Homo sapiens	35-38
16523241-5	2006	In addition, senescent cells whose FAK expression was downregulated by siRNA showed the increased level of apoptosis by staurosporine treatment via caspase-3 activation but not by hydrogen peroxide treatment.	Staurosporine	120-133	caspase 3	Homo sapiens	148-157
16523241-6	2006	Interestingly dephosphorylation at Tyr577 of FAK by PP2 treatment, Src-family kinase inhibitor, induced the apoptosis by staurosporine in senescent cells but dephosphorylation at Tyr397 by downregulation of caveolin-1 was not affected.	Staurosporine	121-134	protein tyrosine kinase 2	Homo sapiens	45-48
16523241-6	2006	Interestingly dephosphorylation at Tyr577 of FAK by PP2 treatment, Src-family kinase inhibitor, induced the apoptosis by staurosporine in senescent cells but dephosphorylation at Tyr397 by downregulation of caveolin-1 was not affected.	Staurosporine	121-134	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	52-55
16523241-6	2006	Interestingly dephosphorylation at Tyr577 of FAK by PP2 treatment, Src-family kinase inhibitor, induced the apoptosis by staurosporine in senescent cells but dephosphorylation at Tyr397 by downregulation of caveolin-1 was not affected.	Staurosporine	121-134	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	67-70
16253964-8	2006	RESULTS: After 3 h of exposure to staurosporine, &gt;50% of the endometrial stromal cells became Annexin V positive.	Staurosporine	34-47	annexin A5	Homo sapiens	97-106
16371645-2	2006	Thrombin-stimulated S1P release was inhibited by staurosporin, whereas Ca(2+)-stimulated release was not.	Staurosporine	49-61	coagulation factor II	Rattus norvegicus	0-8
16368436-4	2006	In HeLa cells, staurosporin (STS) caused a decrease in Ku70 levels without significantly affecting Ku70 mRNA levels.	Staurosporine	15-27	X-ray repair cross complementing 6	Homo sapiens	55-59
16332683-8	2006	However, staurosporine-induced caspase-3 activation in DT40 TKO cells stably expressing the S2681A mutant was markedly enhanced when compared with wild-type or S2681E IP3Rs.	Staurosporine	9-22	caspase 3	Gallus gallus	31-40
16502258-5	2006	Using primary rat hippocampal cultures, staurosporine (STS, 100 nM) induced a time-dependent apoptosis, accompanied by a marked production of reactive oxygen species (ROS), release of cytochrome c and activation of caspase 9 and 3.	Staurosporine	40-53	caspase 9	Rattus norvegicus	215-230
16502258-5	2006	Using primary rat hippocampal cultures, staurosporine (STS, 100 nM) induced a time-dependent apoptosis, accompanied by a marked production of reactive oxygen species (ROS), release of cytochrome c and activation of caspase 9 and 3.	Staurosporine	55-58	caspase 9	Rattus norvegicus	215-230
16500719-0	2006	Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells.	Staurosporine	28-41	erythropoietin	Homo sapiens	10-24
16500719-3	2006	The present work was focused on the study of the Epo protective effect upon human neuroblastoma SH-SY5Y cells subjected to differentiation by staurosporine.	Staurosporine	142-155	erythropoietin	Homo sapiens	49-52
16500719-6	2006	Simultaneously, morphological changes in neurite elongation and interconnection induced by staurosporine were blocked by Epo.	Staurosporine	91-104	erythropoietin	Homo sapiens	121-124
16500719-8	2006	In conclusion, the fact that both events induced by staurosporine, cell apoptosis and differentiation, were prevented in SH-SY5Y cells previously exposed to rHuEpo suggests interrelated signaling pathways triggered by the Epo/EpoR interaction.	Staurosporine	52-65	erythropoietin	Homo sapiens	160-163
16500719-8	2006	In conclusion, the fact that both events induced by staurosporine, cell apoptosis and differentiation, were prevented in SH-SY5Y cells previously exposed to rHuEpo suggests interrelated signaling pathways triggered by the Epo/EpoR interaction.	Staurosporine	52-65	erythropoietin receptor	Homo sapiens	226-230
16892358-2	2006	Based on results from kinase-screening assays that identified a staurosporine analogue as a modest inhibitor of GSK-3beta, a series of 3-indolyl-4-indazolylmaleimides was prepared for study in both enzymatic and cell-based assays.	Staurosporine	64-77	glycogen synthase kinase 3 alpha	Homo sapiens	112-121
16611575-5	2006	The treatment of type I collagen producing fibroblasts, CT-1, with the kinase inhibitor, staurosporine, interfered with DNA-protein interactions on both elements on the COL1A2 proximal promoter.	Staurosporine	89-102	collagen type I alpha 2 chain	Homo sapiens	169-175
16386235-0	2006	Memantine attenuates staurosporine-induced activation of caspase-3 and LDH release in mouse primary neuronal cultures.	Staurosporine	21-34	caspase 3	Mus musculus	57-66
16386235-2	2006	In order to further elucidate this problem, we investigated effect of memantine, an uncompetitive NMDA receptor antagonist and staurosporine alone and in combination on caspase-3 activity and lactate dehydrogenase (LDH) release in primary hippocampal, neocortical and striatal cell cultures on 7 and 12 days in vitro.	Staurosporine	127-140	caspase 3	Mus musculus	169-178
16386235-3	2006	The data showed that the vulnerability of neuronal cells to induction of caspase-3 activity by staurosporine was higher on 7 DIV than on 12 DIV, whereas staurosporine-mediated LDH release increased with days in vitro in striatal culture only.	Staurosporine	95-108	caspase 3	Mus musculus	73-82
16386235-4	2006	A specific inhibitor of caspase-3, AcDEVDCHO (60 microM), completely abolished the effect of staurosporine on this enzyme"s activity, but only partially attenuated staurosporine-induced LDH release in hippocampal cells.	Staurosporine	93-106	caspase 3	Mus musculus	24-33
16386235-4	2006	A specific inhibitor of caspase-3, AcDEVDCHO (60 microM), completely abolished the effect of staurosporine on this enzyme"s activity, but only partially attenuated staurosporine-induced LDH release in hippocampal cells.	Staurosporine	164-177	caspase 3	Mus musculus	24-33
16386235-5	2006	Memantine alone (0.05-2.0 microM) did not induce any cytotoxic effect but attenuated the staurosporine-induced caspase-3 activity and LDH release in hippocampal cultured neurons on each investigated day in vitro.	Staurosporine	89-102	caspase 3	Mus musculus	111-120
16386235-8	2006	These data showed that the induction of caspase-3 activity by staurosporine was more profound in immature cells, however, the staurosporine neurotoxicity, as reflected by LDH release, only partially depended on caspase-3 activation and stage of cell development.	Staurosporine	62-75	caspase 3	Mus musculus	40-49
16620791-4	2006	Using the activation of caspase-3 as indicator of apoptosis, we found that in two cell lines, Jurkat and Mono-Mac 6, staurosporine and DTT elicited apoptosis with a different pattern: staurosporine acted rapidly and at nanomolar concentrations while DTT acted slowly and at higher concentrations (1mM).	Staurosporine	117-130	caspase 3	Homo sapiens	24-33
16620791-4	2006	Using the activation of caspase-3 as indicator of apoptosis, we found that in two cell lines, Jurkat and Mono-Mac 6, staurosporine and DTT elicited apoptosis with a different pattern: staurosporine acted rapidly and at nanomolar concentrations while DTT acted slowly and at higher concentrations (1mM).	Staurosporine	184-197	caspase 3	Homo sapiens	24-33
16620791-9	2006	In agreement with the interplay between the mitochondrial and the endoplasmic reticulum pathways it was found that both staurosporine and DTT induced cytochrome c release.	Staurosporine	120-133	cytochrome c, somatic	Homo sapiens	150-162
16620791-10	2006	Furthermore, 90min incubation with DTT did not induce caspase-4 activation while staurosporine alone or in combination with DTT stimulated caspase-4 activity.	Staurosporine	81-94	caspase 4	Homo sapiens	139-148
16600175-0	2006	Amyloid precursor protein is involved in staurosporine induced glial differentiation of neural progenitor cells.	Staurosporine	41-54	amyloid beta precursor protein	Homo sapiens	0-25
16556605-6	2006	When COS-1 cells transiently transfected with gelsolin cDNA were treated with etoposide or staurosporine, apoptosis-inducing agents, N-myristoylated tGelsolin was generated, as demonstrated by in vivo metabolic labeling.	Staurosporine	91-104	gelsolin	Homo sapiens	46-54
16707598-11	2006	In addition, fenofibrate strongly sensitized BI6FIO cells to the proapoptotic drug staurosporine, further supporting the possibility that fenofibrate-induced down-regulation of Akt function contributes to fenofibrate-mediated inhibition of metastatic potential in this experimental model.	Staurosporine	83-96	thymoma viral proto-oncogene 1	Mus musculus	177-180
16368739-7	2006	TGF-beta(1) caused apoptosis and priming for staurosporine-induced apoptosis.	Staurosporine	45-58	transforming growth factor beta 1	Homo sapiens	0-11
16554962-0	2006	Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells.	Staurosporine	77-90	tumor protein p53	Homo sapiens	14-17
16554962-0	2006	Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells.	Staurosporine	77-90	proline rich membrane anchor 1	Homo sapiens	46-53
16554962-0	2006	Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells.	Staurosporine	77-90	tumor protein p53	Homo sapiens	134-137
16554962-1	2006	We recently argued for a major role of p53 in staurosporine(ST)-induced apoptosis of immortalized epithelial cells, depending on their p53 status.	Staurosporine	46-59	tumor protein p53	Homo sapiens	39-42
16554962-1	2006	We recently argued for a major role of p53 in staurosporine(ST)-induced apoptosis of immortalized epithelial cells, depending on their p53 status.	Staurosporine	46-59	tumor protein p53	Homo sapiens	135-138
16827139-7	2006	ZBP-89 potentiated p53-mediated cell death with 10 nM staurosporine and 100 nM etoposide, but did not in the presence of the R273H p53 mutation.	Staurosporine	54-67	zinc finger protein 148	Homo sapiens	0-6
16827139-7	2006	ZBP-89 potentiated p53-mediated cell death with 10 nM staurosporine and 100 nM etoposide, but did not in the presence of the R273H p53 mutation.	Staurosporine	54-67	tumor protein p53	Homo sapiens	19-22
16484320-5	2006	Both H-89, a specific PKA inhibitor, and PKC inhibitors, staurosporine and calphostin C, antagonized PTH stimulation of beta-catenin levels.	Staurosporine	57-70	parathyroid hormone	Mus musculus	101-104
16484320-5	2006	Both H-89, a specific PKA inhibitor, and PKC inhibitors, staurosporine and calphostin C, antagonized PTH stimulation of beta-catenin levels.	Staurosporine	57-70	catenin (cadherin associated protein), beta 1	Mus musculus	120-132
16770740-0	2006	Staurosporine-induced growth inhibition of glioma cells is accompanied by altered expression of cyclins, CDKs and CDK inhibitors.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	105-109
16770740-4	2006	The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment.	Staurosporine	147-160	cyclin dependent kinase 2	Homo sapiens	14-18
16770740-4	2006	The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment.	Staurosporine	147-160	cyclin dependent kinase 1	Homo sapiens	20-24
16770740-4	2006	The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment.	Staurosporine	147-160	H3 histone pseudogene 16	Homo sapiens	109-112
16770740-4	2006	The levels of CDK2, CDC2, Cyclin A and Cyclin B proteins decreased, while the levels of CDK inhibitors viz., p21 and p27 were found to increase on staurosporine treatment.	Staurosporine	147-160	interferon alpha inducible protein 27	Homo sapiens	117-120
16770740-5	2006	The mRNA levels of CDK2 and CDC2 genes were also found to decrease on staurosporine treatment.	Staurosporine	70-83	cyclin dependent kinase 2	Homo sapiens	19-23
16770740-5	2006	The mRNA levels of CDK2 and CDC2 genes were also found to decrease on staurosporine treatment.	Staurosporine	70-83	cyclin dependent kinase 1	Homo sapiens	28-32
16770740-6	2006	Thus apart from staurosporine"s known direct inhibitory effect on CDK2 and CDC2 activities, staurosporine was found to down-regulate activities of these two kinases by modulating the expression of the kinases themselves as well that of their activating partners (Cyclins) and their inhibitors.	Staurosporine	16-29	cyclin dependent kinase 2	Homo sapiens	66-70
16806956-8	2006	Using Fe(III)-immobilized metal chromatography to determine the apparent phosphorylation status of the enzyme in vivo, we showed that soluble SS was largely dephosphorylated in fruits fed EGTA or staurosporine, compared to fruits fed water or sucrose.	Staurosporine	196-209	sucrose synthase	Solanum lycopersicum	142-144
16452108-5	2006	All these deleterious effects were fully prevented by the intracellular Ca2+ chelator BAPTA/AM (20 microM), the pan-specific PKC inhibitors H7 (100 microM) and staurosporine (1 microM), the inhibitor of Ca2+-dependent PKCs, Go6976 (2 microM), and the PKA activator dibutyryl-cAMP (500 microM).	Staurosporine	160-173	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	251-254
16495229-8	2006	We have established transient and stable transfectants overexpressing wild-type synphilin-1 in human embryonic kidney 293 cells, telecephalon-specific murine 1 neurons, and SH-SY5Y neuroblastoma cells, and we show that both cell systems display lower responsiveness to staurosporine and 6-hydroxydopamine.	Staurosporine	269-282	synuclein alpha interacting protein	Homo sapiens	80-91
16495229-11	2006	Interestingly, we demonstrate that synphilin-1 catabolism is enhanced by staurosporine and blocked by caspase-3 inhibitors.	Staurosporine	73-86	synuclein alpha interacting protein	Homo sapiens	35-46
16628837-4	2006	In osteosarcoma cells treated with staurosporine for 24 h, a substantial proportion of cells (36%) released cytochrome c from the mitochondria before Smac/DIABLO.	Staurosporine	35-48	cytochrome c, somatic	Homo sapiens	108-120
16628837-4	2006	In osteosarcoma cells treated with staurosporine for 24 h, a substantial proportion of cells (36%) released cytochrome c from the mitochondria before Smac/DIABLO.	Staurosporine	35-48	diablo IAP-binding mitochondrial protein	Homo sapiens	150-154
16628837-4	2006	In osteosarcoma cells treated with staurosporine for 24 h, a substantial proportion of cells (36%) released cytochrome c from the mitochondria before Smac/DIABLO.	Staurosporine	35-48	diablo IAP-binding mitochondrial protein	Homo sapiens	155-161
16481323-6	2006	EM20-25 neutralized the antiapoptotic activity of overexpressed BCL-2 toward staurosporine and sensitized BCL-2-expressing cells from leukemic patients to the killing effects of staurosporine, chlorambucil, and fludarabine.	Staurosporine	77-90	BCL2 apoptosis regulator	Homo sapiens	64-69
16458354-7	2006	Expression of [Delta76-86]-IP(3)R1 and of [75-87 T3]-IP(3)R1 increased the propensity of cells to undergo staurosporine-induced apoptosis, but had no effect on the Ca(2+) content in the endoplasmic reticulum.	Staurosporine	106-119	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	27-34
16458354-7	2006	Expression of [Delta76-86]-IP(3)R1 and of [75-87 T3]-IP(3)R1 increased the propensity of cells to undergo staurosporine-induced apoptosis, but had no effect on the Ca(2+) content in the endoplasmic reticulum.	Staurosporine	106-119	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	53-60
16572731-8	2006	Mammalian cells containing p26 were more thermotolerant than cells transfected with the expression vector only, and as measured by annexin V labeling, Hoescht 33342 nuclear staining and procaspase-3 activation, transfected cells effectively resisted apoptosis induction by heat and staurosporine.	Staurosporine	282-295	transmembrane p24 trafficking protein 3	Homo sapiens	27-30
16213157-11	2006	The Lance assay was further validated with a diverse panel of literature inhibitors, in which the PKC inhibitors staurosporine, Ro-318220, and the PKA inhibitor Balanol potently inhibited S6K.	Staurosporine	113-126	ribosomal protein S6 kinase B1	Homo sapiens	188-191
16428383-6	2006	Consistent with these data, NEU3 markedly inhibited staurosporine-induced caspase-3 activity and enhanced IL-6-dependent inhibition, which was abolished by LY294002, a PI3K inhibitor.	Staurosporine	52-65	neuraminidase 3	Homo sapiens	28-32
16428383-6	2006	Consistent with these data, NEU3 markedly inhibited staurosporine-induced caspase-3 activity and enhanced IL-6-dependent inhibition, which was abolished by LY294002, a PI3K inhibitor.	Staurosporine	52-65	caspase 3	Homo sapiens	74-83
16251475-4	2006	Pretreatment with BAPTA-AM, staurosporine (PKC inhibitor), or Go6976 (specific inhibitor for Ca(2+)-dependent PKC) abrogated ERK phosphorylation, suggesting the role of Ca(2+) and Ca(2+)-dependent PKC in Hcy-induced ERK activation.	Staurosporine	28-41	mitogen-activated protein kinase 1	Homo sapiens	125-128
16251475-8	2006	Pretreatment with an ERK1/2 blocker (PD-98059), staurosporine, folate, or NAC modulated Hcy-induced MMP-9 activation as measured using zymography.	Staurosporine	48-61	matrix metallopeptidase 9	Homo sapiens	100-105
16520893-9	2006	In addition, it also reduces cytochrome c release induced by Vpr, staurosporine and TNFalpha.	Staurosporine	66-79	cytochrome c, somatic	Homo sapiens	29-41
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Staurosporine	157-170	sphingosine kinase 1	Homo sapiens	58-62
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Staurosporine	157-170	mitogen-activated protein kinase 1	Homo sapiens	91-136
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Staurosporine	157-170	mitogen-activated protein kinase 1	Homo sapiens	138-141
16571380-7	2006	In mechanistic terms, the transcriptional upregulation of SK-1 is dependent on PKC and the extracellular signal-regulated protein kinase (ERK) cascade since staurosporine and the MEK inhibitor U0126 abolish the TPA-induced SK-1 induction.	Staurosporine	157-170	sphingosine kinase 1	Homo sapiens	223-227
16376586-7	2006	Our studies show RAMP3 down regulation on staurosporine treatment of astrocytes, suggesting protein kinase C inhibition as a possible strategy for inhibiting AM activity and thereby growth of glioma cells.	Staurosporine	42-55	receptor activity modifying protein 3	Homo sapiens	17-22
16487264-16	2006	Staurosporine (10(-6) mol/L), NAC (10(-5) mol/L) and PD 98059 (10(-7) mol/L) attenuated the phosphorylation of p44/42 MAPK.	Staurosporine	0-13	mitogen-activated protein kinase 3	Mus musculus	111-114
16152591-4	2006	The VEGF-D-expressing MCF-7 and MDA-MB-231 lines displayed resistance to apoptosis induced by hypoxia, staurosporin and cycloheximide.	Staurosporine	103-115	vascular endothelial growth factor D	Homo sapiens	4-10
16543731-7	2006	In addition, EGF effect was blocked by neomycin and U 73122 [phospholipase C (PLC) inhibitors] as well as staurosporine and bisindolylmaleimide I [protein kinase C (PKC) inhibitors].	Staurosporine	106-119	epidermal growth factor	Mus musculus	13-16
16460276-4	2006	This contraction is suppressed by staurosporine, implying participation of a Ca2+-independent MLCK.	Staurosporine	34-47	myosin light chain kinase	Homo sapiens	94-98
16420423-4	2006	Staurosporin application, routinely used to induce apoptosis in mammalian neurons through the activating cleavage of caspase-3, did not result in the appearance of a smaller subunit corresponding to the active caspase in the snail.	Staurosporine	0-12	caspase 3	Homo sapiens	117-126
17086355-7	2006	Staurosporine sensitivity is also Rac-independent, suggesting Tiam1"s effects on apoptosis require other effectors.	Staurosporine	0-13	AKT serine/threonine kinase 1	Homo sapiens	34-37
17086355-7	2006	Staurosporine sensitivity is also Rac-independent, suggesting Tiam1"s effects on apoptosis require other effectors.	Staurosporine	0-13	TIAM Rac1 associated GEF 1	Homo sapiens	62-67
16288739-7	2006	Furthermore, through profiling of proteolytic activation, we demonstrate, for the first time, that staurosporine activates a chymotrypsin-like serine protease-dependent cell death in HL-60 cells independently, but in parallel with the caspase controlled systems.	Staurosporine	99-112	coagulation factor II, thrombin	Homo sapiens	143-158
16199031-3	2005	We compared the apoptotic changes of the nuclear matrix in staurosporine-treated caspase-3-deficient MCF-7 cells transfected with intact CASP-3 gene (MCF-7c3) or an empty vector (MCF-7v) as a control.	Staurosporine	59-72	caspase 3	Homo sapiens	81-90
16201970-7	2005	Ca2+-independent contraction of calmodulin-depleted tissue in response to microcystin was resistant to MLCK inhibitors [AV25 (a 25-amino-acid peptide derived from the autoinhibitory domain of MLCK), ML-7, ML-9 and wortmannin], protein kinase C inhibitor (GF109203X) and Rho-associated kinase inhibitors (Y-27632 and H-1152), but blocked by the non-selective kinase inhibitor staurosporine.	Staurosporine	375-388	calmodulin 1	Rattus norvegicus	32-42
16221682-9	2005	Vesicles immunoprecipitated from low density microsomes using antibodies directed against mTOR or RICTOR had phosphatidylinositol 3,4,5-trisphosphate-stimulated Ser-473 activity that was sensitive to wortmannin but not staurosporine.	Staurosporine	219-232	mechanistic target of rapamycin kinase	Homo sapiens	90-94
16221682-9	2005	Vesicles immunoprecipitated from low density microsomes using antibodies directed against mTOR or RICTOR had phosphatidylinositol 3,4,5-trisphosphate-stimulated Ser-473 activity that was sensitive to wortmannin but not staurosporine.	Staurosporine	219-232	RPTOR independent companion of MTOR complex 2	Homo sapiens	98-104
16266318-3	2005	In this study, we examined IGF-1 signals that protect human and rat VSMC from staurosporine (STAU)- and c-myc- induced apoptosis, respectively.	Staurosporine	78-91	insulin like growth factor 1	Homo sapiens	27-32
16266318-3	2005	In this study, we examined IGF-1 signals that protect human and rat VSMC from staurosporine (STAU)- and c-myc- induced apoptosis, respectively.	Staurosporine	93-97	insulin like growth factor 1	Homo sapiens	27-32
16273285-9	2005	The enhancement of regucalcin mRNA expression in transfectants was significantly suppressed in the presence of staurosporine (10(-10) M), an inhibitor of protein kinase C. This enhancement was not significantly changed in the presence of dibucaine (10(-8) M), PD98059 (10(-8) M) or vanadate (10(-6) M).	Staurosporine	111-124	regucalcin	Rattus norvegicus	19-29
16303606-3	2005	Progesterone (P4) increased (P&lt;0.01) while staurosporine decreased (P&lt;0.01-P&lt;0.001) bcl-2 expression at both stages of the estrous cycle studied.	Staurosporine	46-59	BCL2 apoptosis regulator	Bos taurus	93-98
16303606-5	2005	Treatment with aminoglutethimide (blocker of cytochrome P450scc; 1.5 x 10(-4)M), nitric oxide donor (spermine NONOate), and staurosporine increased bax expression in cells collected from both experimental periods.	Staurosporine	124-137	BCL2 associated X, apoptosis regulator	Homo sapiens	148-151
16303606-9	2005	Moreover, P4 decreased (P&lt;0.05) while staurosporine increased (P&lt;0.01) the ratio of bax/bcl-2 at both stages of the cycle.	Staurosporine	41-54	BCL2 associated X, apoptosis regulator	Bos taurus	90-93
16303606-9	2005	Moreover, P4 decreased (P&lt;0.05) while staurosporine increased (P&lt;0.01) the ratio of bax/bcl-2 at both stages of the cycle.	Staurosporine	41-54	BCL2 apoptosis regulator	Bos taurus	94-99
16253284-7	2006	That protection results in a significant reduction of caspase-3 activity induced by staurosporine which by its turn seems to result from a protection observed in the membrane receptor pathway (caspase-8) together with a protection observed in the mitochondrial pathway (caspase-9).	Staurosporine	84-97	caspase 3	Homo sapiens	54-63
16253284-7	2006	That protection results in a significant reduction of caspase-3 activity induced by staurosporine which by its turn seems to result from a protection observed in the membrane receptor pathway (caspase-8) together with a protection observed in the mitochondrial pathway (caspase-9).	Staurosporine	84-97	caspase 8	Homo sapiens	193-202
16253284-7	2006	That protection results in a significant reduction of caspase-3 activity induced by staurosporine which by its turn seems to result from a protection observed in the membrane receptor pathway (caspase-8) together with a protection observed in the mitochondrial pathway (caspase-9).	Staurosporine	84-97	caspase 9	Homo sapiens	270-279
16382158-7	2006	We also show that SPAK activity is markedly inhibited by staurosporine and K252a, partially inhibited by N-ethylmaleimide and diamide, and unaffected by arsenite.	Staurosporine	57-70	oxidative stress responsive kinase 1 L homeolog	Xenopus laevis	18-22
16219768-0	2005	WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.	Staurosporine	57-70	WW domain containing oxidoreductase	Homo sapiens	0-4
16219768-6	2005	Knockdown of WOX1 protein expression by small interfering RNA resulted in L929 fibroblast resistance to apoptosis by tumor necrosis factor, staurosporine, UV light, and ectopic p53, indicating an essential role of WOX1 in stress stimuli-induced apoptosis.	Staurosporine	140-153	WW domain containing oxidoreductase	Homo sapiens	13-17
16263764-13	2005	DO, BMP15 and BMP6 were also able to protect cumulus cells from undergoing apoptosis induced by staurosporine.	Staurosporine	96-109	bone morphogenetic protein 15	Bos taurus	4-9
16263764-13	2005	DO, BMP15 and BMP6 were also able to protect cumulus cells from undergoing apoptosis induced by staurosporine.	Staurosporine	96-109	bone morphogenetic protein 6	Bos taurus	14-18
16153713-0	2005	Effect of NMDA on staurosporine-induced activation of caspase-3 and LDH release in mouse neocortical and hippocampal cells.	Staurosporine	18-31	caspase 3	Mus musculus	54-63
16153713-4	2005	A persistent activation of caspase-3 by staurosporine was found at all experimental stages.	Staurosporine	40-53	caspase 3	Mus musculus	27-36
16153713-5	2005	Despite of certain differences in susceptibility to NMDA and staurosporine, both tissues responded to regulatory action of NMDA towards staurosporine-activated caspase-3 in a similar way.	Staurosporine	136-149	caspase 3	Mus musculus	160-169
16153713-6	2005	Combined treatment with NMDA and staurosporine resulted in a substantial increase in caspase-3 activity in neocortical and hippocampal neurons on 2 DIV.	Staurosporine	33-46	caspase 3	Mus musculus	85-94
16153713-8	2005	In contrast, NMDA substantially inhibited staurosporine-induced caspase-3 activity on 7 DIV in neocortical and hippocampal cultures.	Staurosporine	42-55	caspase 3	Mus musculus	64-73
16153713-10	2005	Changes in vulnerability to NMDA- and staurosporine-mediated activation of caspase-3 were not strictly related to LDH release.	Staurosporine	38-51	caspase 3	Mus musculus	75-84
16225760-0	2005	Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine.	Staurosporine	103-116	protein kinase C alpha	Homo sapiens	10-32
16225760-0	2005	Effect of protein kinase C alpha, caspase-3, and survivin on apoptosis of oral cancer cells induced by staurosporine.	Staurosporine	103-116	caspase 3	Homo sapiens	34-43
16225760-1	2005	AIM: To elucidate inhibition of protein kinase C alpha (PKC alpha) activity by staurosporine on apoptosis of oral cancer cell line tongue squamous cell carcinoma (TSCCa) cells and to clarify the role of survivin and caspase-3 in mediating apoptosis.	Staurosporine	79-92	protein kinase C alpha	Homo sapiens	32-54
16225760-1	2005	AIM: To elucidate inhibition of protein kinase C alpha (PKC alpha) activity by staurosporine on apoptosis of oral cancer cell line tongue squamous cell carcinoma (TSCCa) cells and to clarify the role of survivin and caspase-3 in mediating apoptosis.	Staurosporine	79-92	protein kinase C alpha	Homo sapiens	56-65
16225760-7	2005	Marked cell accumulation in G2/M phase was observed after 100 nmol/L staurosporine exposure for 6 h and 12 h. In addition, the percentage of apoptosis increased in a time-dependent manner, from 2.9% in control cultures to approximately 27.4% at 100 nmol/L staurosporine treatment for 24 h. Staurosporine displayed difference in inhibitory efficacy between cytosolic and membrance-derived PKC alpha.	Staurosporine	69-82	protein kinase C alpha	Homo sapiens	388-397
16225760-8	2005	The content of PKCalpha in membrane versus cytosol decreased quickly, from 0.45 in ethanol-treated control cultures to 0.18 after staurosporine exposure for 24 h (P&lt;0.01).	Staurosporine	130-143	protein kinase C alpha	Homo sapiens	15-23
16225760-9	2005	After treatment with staurosporine, a time-dependent reduction of survivin and an activation of caspase-3 were observed in TSCCa cells.	Staurosporine	21-34	caspase 3	Homo sapiens	96-105
16225760-11	2005	Inhibition of PKCalpha activity might be a potential mechanism for staurosporine to induce apoptosis in this cell line.	Staurosporine	67-80	protein kinase C alpha	Homo sapiens	14-22
16246067-8	2005	In addition, the action of the PtdIns 4-kinase, Stt4p (PtdIns 4-kinase encoded by the STT4 gene that complements the stt4 mutation causing staurosporine and temperature-sensitive growth) is also required for PtdSer transport to the locus of Psd2p.	Staurosporine	139-152	pleckstrin and Sec7 domain containing 2	Homo sapiens	241-246
15913957-5	2005	Treatment of NESK-transfected HeLa cells with TNF-alpha in the presence of cycloheximide or with staurosporine induced proteolytic cleavage of NESK.	Staurosporine	97-110	Nik related kinase	Homo sapiens	13-17
15913957-5	2005	Treatment of NESK-transfected HeLa cells with TNF-alpha in the presence of cycloheximide or with staurosporine induced proteolytic cleavage of NESK.	Staurosporine	97-110	Nik related kinase	Homo sapiens	143-147
16220076-5	2005	The inhibition of Kir currents by ET-1 was abolished by pretreatment with the protein kinase C (PKC) inhibitor staurosporine (100 nM) or GF 109203X (1 microm).	Staurosporine	111-124	endothelin-1	Oryctolagus cuniculus	34-38
16364974-10	2005	Furthermore, we showed that antide (GnRHR antagonist) significantly stimulated the GnRHR promoter activity and inhibition of protein kinase C (PKC) pathway by staurosporine could also up-regulate the promoter activity in dose- and time-dependent manners.	Staurosporine	159-172	gonadotropin releasing hormone receptor	Homo sapiens	36-41
16364974-10	2005	Furthermore, we showed that antide (GnRHR antagonist) significantly stimulated the GnRHR promoter activity and inhibition of protein kinase C (PKC) pathway by staurosporine could also up-regulate the promoter activity in dose- and time-dependent manners.	Staurosporine	159-172	gonadotropin releasing hormone receptor	Homo sapiens	83-88
16049016-1	2005	We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the nuclear morphology and DNA degradation pattern in staurosporine-induced apoptosis.	Staurosporine	174-187	apoptosis inducing factor mitochondria associated 1	Homo sapiens	37-62
16049016-1	2005	We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the nuclear morphology and DNA degradation pattern in staurosporine-induced apoptosis.	Staurosporine	174-187	apoptosis inducing factor mitochondria associated 1	Homo sapiens	64-67
16049016-1	2005	We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the nuclear morphology and DNA degradation pattern in staurosporine-induced apoptosis.	Staurosporine	174-187	DNA fragmentation factor subunit beta	Homo sapiens	86-109
16049016-1	2005	We have assessed the contribution of apoptosis-inducing factor (AIF) and inhibitor of caspase-activated DNase (ICAD) to the nuclear morphology and DNA degradation pattern in staurosporine-induced apoptosis.	Staurosporine	174-187	DNA fragmentation factor subunit alpha	Homo sapiens	111-115
16007152-3	2005	In contrast, when human lymphoma U937 and Jurkat cells were treated with Pc 4-PDT, staurosporine (STS) or UVC, Mcl-1 was cleaved to generate a 28-kDa fragment over a 2-4 h period.	Staurosporine	83-96	proprotein convertase subtilisin/kexin type 4	Homo sapiens	73-77
16007152-3	2005	In contrast, when human lymphoma U937 and Jurkat cells were treated with Pc 4-PDT, staurosporine (STS) or UVC, Mcl-1 was cleaved to generate a 28-kDa fragment over a 2-4 h period.	Staurosporine	83-96	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	111-116
16007152-3	2005	In contrast, when human lymphoma U937 and Jurkat cells were treated with Pc 4-PDT, staurosporine (STS) or UVC, Mcl-1 was cleaved to generate a 28-kDa fragment over a 2-4 h period.	Staurosporine	98-101	proprotein convertase subtilisin/kexin type 4	Homo sapiens	73-77
16007152-3	2005	In contrast, when human lymphoma U937 and Jurkat cells were treated with Pc 4-PDT, staurosporine (STS) or UVC, Mcl-1 was cleaved to generate a 28-kDa fragment over a 2-4 h period.	Staurosporine	98-101	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	111-116
16199031-3	2005	We compared the apoptotic changes of the nuclear matrix in staurosporine-treated caspase-3-deficient MCF-7 cells transfected with intact CASP-3 gene (MCF-7c3) or an empty vector (MCF-7v) as a control.	Staurosporine	59-72	caspase 3	Homo sapiens	137-143
16175601-8	2005	FAP overexpression enhanced staurosporine streptomyces-stimulated apoptosis in both cell lines.	Staurosporine	28-41	fibroblast activation protein alpha	Homo sapiens	0-3
15967610-7	2005	RESULTS: SKI 306X significantly prevented staurosporin-induced apoptosis.	Staurosporine	42-54	Ski proto-oncogene	Rattus norvegicus	9-12
15967610-9	2005	Although the level of Bcl-2 expression was decreased after staurosporin treatment, it was sustained after the combination treatment with Clematis mandshurica.	Staurosporine	59-71	BCL2, apoptosis regulator	Rattus norvegicus	22-27
15967610-10	2005	Whereas staurosporin induced the degradation of 32 kDa caspase-3 precursor and the production of 85-kDa cleavage products of PARP in a time-dependent fashion, Clematis mandshurica treatment prevented those manifestations.	Staurosporine	8-20	caspase 3	Rattus norvegicus	55-64
16204039-6	2005	Its overexpression inhibited pro-caspase-9 activation, leading to the suppression of the cell death induced by a protein kinase inhibitor, staurosporine, or a chemotherapeutic reagent, etoposide (VP-16).	Staurosporine	139-152	caspase 9	Homo sapiens	33-42
16061221-10	2005	Finally, cell viability assays indicated that the BH1-4 domains of Bcl-X(L) were the primary domains required for inhibiting staurosporine-induced apoptosis, suggesting that distinct domains of Bcl-X(L) are involved in antagonizing Bax and Bad and in apoptosis inhibition.	Staurosporine	125-138	BCL2 like 1	Homo sapiens	67-75
16061221-10	2005	Finally, cell viability assays indicated that the BH1-4 domains of Bcl-X(L) were the primary domains required for inhibiting staurosporine-induced apoptosis, suggesting that distinct domains of Bcl-X(L) are involved in antagonizing Bax and Bad and in apoptosis inhibition.	Staurosporine	125-138	BCL2 like 1	Homo sapiens	194-202
16061221-10	2005	Finally, cell viability assays indicated that the BH1-4 domains of Bcl-X(L) were the primary domains required for inhibiting staurosporine-induced apoptosis, suggesting that distinct domains of Bcl-X(L) are involved in antagonizing Bax and Bad and in apoptosis inhibition.	Staurosporine	125-138	BCL2 associated X, apoptosis regulator	Homo sapiens	232-235
16099944-7	2005	T-cad+-HUVEC exposed to stress (serum-deprivation, TNF-alpha, actinomycin D, staurosporine) exhibited reduced caspase activation together with increased cell survival.	Staurosporine	77-90	cadherin 13	Homo sapiens	0-12
15902200-9	2005	Moreover, Nix upregulation in staurosporine-treated SH-SY5Y cells and dexamethasone-treated A1.1 cells supports a more generalized role for Nix in apoptotic cell death.	Staurosporine	30-43	BCL2 interacting protein 3 like	Homo sapiens	10-13
16191103-3	2005	In human fibroblasts, exposed to the apoptosis-inducing drug staurosporine (STS), the release of the lysosomal protease cathepsin D to the cytosol was observed by immunocytochemistry.	Staurosporine	61-74	cathepsin D	Homo sapiens	120-131
16191103-3	2005	In human fibroblasts, exposed to the apoptosis-inducing drug staurosporine (STS), the release of the lysosomal protease cathepsin D to the cytosol was observed by immunocytochemistry.	Staurosporine	76-79	cathepsin D	Homo sapiens	120-131
15902200-9	2005	Moreover, Nix upregulation in staurosporine-treated SH-SY5Y cells and dexamethasone-treated A1.1 cells supports a more generalized role for Nix in apoptotic cell death.	Staurosporine	30-43	BCL2 interacting protein 3 like	Homo sapiens	140-143
16245150-2	2005	We have established transgenic mouse lines specifically expressing p 35 in cardiomyocytes, and primary cardiomyocytes isolated from these mice exhibit resistance to staurosporine-induced apoptosis.	Staurosporine	165-178	interleukin 12a	Mus musculus	67-71
16181426-8	2005	Furthermore, in brain slices, FN stimulation reduced the staurosporine-induced insertion of the pro-apoptotic protein Bax into the mitochondria, a critical step in the mitochondrial mechanisms of apoptosis.	Staurosporine	57-70	BCL2 associated X, apoptosis regulator	Rattus norvegicus	118-121
16181427-9	2005	Transducible loop deleted Bcl-2 increases the survival of cortical neurons following trophic factor withdrawal and also rescues neural cell lines from staurosporine-induced death.	Staurosporine	151-164	BCL2 apoptosis regulator	Homo sapiens	26-31
16245150-6	2005	Thus, cardiomyocyte expression of p 35 prevented cell death induced by staurosporine or caspase-8 deficiency.	Staurosporine	71-84	interleukin 12a	Mus musculus	34-38
16255241-5	2005	SIPK-mediated enhancement of WRKY1 DNA-binding activity was inhibited by staurosporine, a general kinase inhibitor.	Staurosporine	73-86	mitogen-activated protein kinase homolog NTF4-like	Nicotiana tabacum	0-4
16255241-5	2005	SIPK-mediated enhancement of WRKY1 DNA-binding activity was inhibited by staurosporine, a general kinase inhibitor.	Staurosporine	73-86	probable WRKY transcription factor 26	Nicotiana tabacum	29-34
15994297-10	2005	In response to treatment with staurosporine, caspase-3 and -6 (but not caspase-7) enzymatic activities were induced.	Staurosporine	30-43	caspase 3	Mus musculus	45-61
16120467-7	2005	Exposure of acute hippocampal slices to either chelerythrine or staurosporine completely blocked enhanced phosphorylation of Pyk2 by A23187, suggesting a possible involvement of PKMxi and typical PKCs in Pyk2 activation by Ca2+.	Staurosporine	64-77	protein tyrosine kinase 2 beta	Rattus norvegicus	125-129
16120467-7	2005	Exposure of acute hippocampal slices to either chelerythrine or staurosporine completely blocked enhanced phosphorylation of Pyk2 by A23187, suggesting a possible involvement of PKMxi and typical PKCs in Pyk2 activation by Ca2+.	Staurosporine	64-77	protein tyrosine kinase 2 beta	Rattus norvegicus	204-208
15961701-4	2005	METHODS AND RESULTS: Treatment of VSMCs with staurosporine induced apoptosis and cleavage of Mst1, which is a marker of its activation, as well as activation of caspase 3.	Staurosporine	45-58	macrophage stimulating 1	Rattus norvegicus	93-97
15961701-4	2005	METHODS AND RESULTS: Treatment of VSMCs with staurosporine induced apoptosis and cleavage of Mst1, which is a marker of its activation, as well as activation of caspase 3.	Staurosporine	45-58	caspase 3	Rattus norvegicus	161-170
16144937-10	2005	Down-regulation of cIAP2 expression by small interfering RNA sensitized SK-OV-3 cells to apoptosis inducer staurosporine.	Staurosporine	107-120	baculoviral IAP repeat containing 3	Homo sapiens	19-24
16259378-5	2005	Mg2+ efflux in KCl medium by K+/Mg2+ antiport via the unspecific choline exchanger was not significantly reduced in SHR and was equally affected by PMA and staurosporine in WKY and SHR.	Staurosporine	156-169	mucin 7, secreted	Homo sapiens	0-3
16079129-3	2005	We show that under basal and staurosporine-induced conditions, the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL)-positive cells was lower in wild-type PINK1 expressing SH-SY5Y cells than in mock-transfected cells.	Staurosporine	29-42	PTEN induced kinase 1	Homo sapiens	192-197
16079129-5	2005	We show that overexpression of wild-type PINK1 strongly reduced both basal and staurosporine-induced caspase 3 activity.	Staurosporine	79-92	PTEN induced kinase 1	Homo sapiens	41-46
16079129-5	2005	We show that overexpression of wild-type PINK1 strongly reduced both basal and staurosporine-induced caspase 3 activity.	Staurosporine	79-92	caspase 3	Homo sapiens	101-110
16079129-6	2005	Overexpression of wild-type PINK1 also reduced the levels of cleaved caspase-9, caspase-3, caspase-7, and activated poly(ADP-ribose) polymerase under both basal and staurosporine-induced conditions.	Staurosporine	165-178	PTEN induced kinase 1	Homo sapiens	28-33
16079129-8	2005	Together, these results suggest that PINK1 reduces the basal neuronal pro-apoptotic activity and protects neurons from staurosporine-induced apoptosis.	Staurosporine	119-132	PTEN induced kinase 1	Homo sapiens	37-42
15920013-8	2005	ICAM-2-deficient cells show defective in vitro migration, as well as increased apoptosis in response to serum deprivation, anti-Fas antibody, or staurosporine.	Staurosporine	145-158	intercellular adhesion molecule 2	Homo sapiens	0-6
16094403-3	2005	Moreover, while Bfl-1 suppresses apoptosis induced by staurosporine or cytokine withdrawal, it is proapoptotic in response to tumor necrosis factor (TNF) receptor activation in FL5.12 pro-B cells.	Staurosporine	54-67	B cell leukemia/lymphoma 2 related protein A1a	Mus musculus	16-21
15946695-8	2005	Protein kinase C (PKC) inhibitors, staurosporine, bisindolylmaleimide I, and H-7 also blocked ANG II-induced stimulation of 2-DG uptake.	Staurosporine	35-48	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	94-97
15994297-10	2005	In response to treatment with staurosporine, caspase-3 and -6 (but not caspase-7) enzymatic activities were induced.	Staurosporine	30-43	caspase 7	Mus musculus	71-80
15941674-9	2005	Moreover, okadaic acid-induced phosphorylation of Ku80 was inhibited by nanomolar concentrations of the protein kinase inhibitor staurosporine.	Staurosporine	129-142	X-ray repair cross complementing 5	Homo sapiens	50-54
16085054-5	2005	In the present study we demonstrated that the treatment of primary cultured hepatocytes with PXR agonists increased hepatocyte viability and protects them from staurosporine-induced apoptosis.	Staurosporine	160-173	nuclear receptor subfamily 1 group I member 2	Homo sapiens	93-96
15744749-4	2005	However, Cch-stimulated MAPK/ERK phosphorylation was completely blocked by myristoylated PKC-zeta pseudosubstrate, a specific inhibitor of PKC-zeta, and high doses of staurosporine.	Staurosporine	167-180	mitogen-activated protein kinase 1	Homo sapiens	29-32
16081820-10	2005	Moreover, IFN-gamma-induced gammaIP-10 expression was completely abolished by the protein kinase C inhibitor staurosporine, and partially reduced by U0126, a specific inhibitor for ERKs.	Staurosporine	109-122	interferon gamma	Rattus norvegicus	10-19
15831699-0	2005	Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog.	Staurosporine	62-75	Janus kinase 3	Homo sapiens	25-29
15831699-6	2005	Here, we present the crystal structure of the Jak3 kinase domain in complex with staurosporine analog AFN941.	Staurosporine	81-94	Janus kinase 3	Homo sapiens	46-50
16038904-2	2005	We found that p23 is degraded during apoptosis induced by several stimuli, including Fas and TNFalpha-receptor activation as well as staurosporine treatment.	Staurosporine	133-146	prostaglandin E synthase 3	Homo sapiens	14-17
15968641-4	2005	Induction of PTEN by removal of doxycycline enhanced both capsase-3 and cell death with staurosporine, wortmannin, or C2-ceramide, whereas antisense PTEN had the reverse effect.	Staurosporine	88-101	phosphatase and tensin homolog	Homo sapiens	13-17
15907805-5	2005	Jurkat/TP cells showed weak phosphorylation of Bcl-2, and kinase inhibitors staurosporine and genistein attenuated not only MIA-induced Bcl-2 phosphorylation but also cytotoxicity of MIA in Jurkat/CV, but not in Jurkat/TP.	Staurosporine	76-89	BCL2 apoptosis regulator	Homo sapiens	136-141
15967383-1	2005	Previous studies showed that 5-fluorouracil (5-FU) and Staurosporine (ST), a protein kinase inhibitor (PKI), were able to increase the expression of carcinoembryonic antigen (CEA) in human colon cancer cells.	Staurosporine	55-68	CEA cell adhesion molecule 3	Homo sapiens	149-173
15967383-1	2005	Previous studies showed that 5-fluorouracil (5-FU) and Staurosporine (ST), a protein kinase inhibitor (PKI), were able to increase the expression of carcinoembryonic antigen (CEA) in human colon cancer cells.	Staurosporine	55-68	CEA cell adhesion molecule 3	Homo sapiens	175-178
15967383-1	2005	Previous studies showed that 5-fluorouracil (5-FU) and Staurosporine (ST), a protein kinase inhibitor (PKI), were able to increase the expression of carcinoembryonic antigen (CEA) in human colon cancer cells.	Staurosporine	70-72	CEA cell adhesion molecule 3	Homo sapiens	149-173
15967383-1	2005	Previous studies showed that 5-fluorouracil (5-FU) and Staurosporine (ST), a protein kinase inhibitor (PKI), were able to increase the expression of carcinoembryonic antigen (CEA) in human colon cancer cells.	Staurosporine	70-72	CEA cell adhesion molecule 3	Homo sapiens	175-178
15967383-6	2005	Flow cytometric analysis showed that treatment of cells with 5-FU + ST resulted in a synergistic increase of CEA expression, being higher than that obtainable with both agents alone.	Staurosporine	68-70	CEA cell adhesion molecule 3	Homo sapiens	109-112
15929065-4	2005	This PPT1 overexpression also resulted in protection against cell death induced by either staurosporine or C(2)-ceramide.	Staurosporine	90-103	palmitoyl-protein thioesterase 1	Homo sapiens	5-9
15929065-8	2005	NSMase2 overexpression enhanced cell death induced by staurosporine or C(2)-ceramide, in contrast to the protective effect of PPT1 overexpression.	Staurosporine	54-67	sphingomyelin phosphodiesterase 3	Homo sapiens	0-7
15961378-8	2005	Upon induction of apoptosis by a number of stimuli, including menadione, staurosporine, sodium nitroprusside, and hypoxia-reoxygenation-serum withdrawal, we could observe the translocation of Bax from cytosol to mitochondria.	Staurosporine	73-86	BCL2 associated X, apoptosis regulator	Rattus norvegicus	192-195
16117614-7	2005	They also substantiated that PKCalpha is a part of the TPA-activated upstream signal pathway of NF-kappaB, since NF-kappaB activity was inhibited by staurosporine (a PKC inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor) in a western blot analysis.	Staurosporine	149-162	protein kinase C alpha	Homo sapiens	29-37
16134057-5	2005	To further investigate mRNA expression of TNF, staurosporine was used.	Staurosporine	47-60	tumor necrosis factor	Homo sapiens	42-45
16134057-10	2005	Staurosporine attenuated mRNA expression of TNF (p &lt; 0.05), but not interleukin (IL)-6, which was detected prior to TNF.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	44-47
16134057-14	2005	Dust-induced expression of IL-6 precedes that of TNF and the induction pathways differ with regard to staurosporine sensitivity.	Staurosporine	102-115	interleukin 6	Homo sapiens	27-31
15878861-6	2005	Upon staurosporine-stimulated cell death, activated Bax is recruited to the Mfn2-containing puncta; however, Bax activation and cytochrome c release are inhibited in the presence of the dominant active mutants of Mfn2.	Staurosporine	5-18	BCL2 associated X, apoptosis regulator	Homo sapiens	52-55
15878861-6	2005	Upon staurosporine-stimulated cell death, activated Bax is recruited to the Mfn2-containing puncta; however, Bax activation and cytochrome c release are inhibited in the presence of the dominant active mutants of Mfn2.	Staurosporine	5-18	mitofusin 2	Homo sapiens	76-80
15878861-6	2005	Upon staurosporine-stimulated cell death, activated Bax is recruited to the Mfn2-containing puncta; however, Bax activation and cytochrome c release are inhibited in the presence of the dominant active mutants of Mfn2.	Staurosporine	5-18	BCL2 associated X, apoptosis regulator	Homo sapiens	109-112
15878861-6	2005	Upon staurosporine-stimulated cell death, activated Bax is recruited to the Mfn2-containing puncta; however, Bax activation and cytochrome c release are inhibited in the presence of the dominant active mutants of Mfn2.	Staurosporine	5-18	cytochrome c, somatic	Homo sapiens	128-140
15878861-6	2005	Upon staurosporine-stimulated cell death, activated Bax is recruited to the Mfn2-containing puncta; however, Bax activation and cytochrome c release are inhibited in the presence of the dominant active mutants of Mfn2.	Staurosporine	5-18	mitofusin 2	Homo sapiens	213-217
16207092-4	2005	Here, hDLG is shown to be a caspase target during UV irradiation and staurosporine (STS)-induced apoptosis in HaCaT and CaCo-2 cells.	Staurosporine	69-82	discs large MAGUK scaffold protein 1	Homo sapiens	6-10
16207092-4	2005	Here, hDLG is shown to be a caspase target during UV irradiation and staurosporine (STS)-induced apoptosis in HaCaT and CaCo-2 cells.	Staurosporine	84-87	discs large MAGUK scaffold protein 1	Homo sapiens	6-10
16602625-4	2005	Interestingly, broad-spectrum serine-threonine protein kinase inhibitors which also inhibit PKC, staurosporine and H-7, stimulated expression from the MRP2 promoter instead of inhibiting it.	Staurosporine	97-110	ATP binding cassette subfamily C member 2	Homo sapiens	151-155
16602625-6	2005	MRP2 induction by staurosporine and H-7 was shown to have phenotypic consequences in whole cells, rendering them more resistant to etoposide and increasing their ability to export calcein through the plasma membrane.	Staurosporine	18-31	ATP binding cassette subfamily C member 2	Homo sapiens	0-4
16117614-7	2005	They also substantiated that PKCalpha is a part of the TPA-activated upstream signal pathway of NF-kappaB, since NF-kappaB activity was inhibited by staurosporine (a PKC inhibitor) and pyrrolidine dithiocarbamate (an NF-kappaB inhibitor) in a western blot analysis.	Staurosporine	149-162	protein kinase C alpha	Homo sapiens	29-32
15806167-5	2005	We found cten was cleaved during apoptosis induced by staurosporine in normal prostate epithelial cells.	Staurosporine	54-67	tensin 4	Homo sapiens	9-13
16335803-5	2005	Treatment of differentiated C2C12 mouse muscle myoblasts with the inducers of apoptosis staurosporine, TPEN, doxorubicin, or UV irradiation resulted in the disappearance of the alpha subunit of PhK as determined by immunoblotting, as well as a concurrent increase in caspase-3 activity.	Staurosporine	88-101	phosphorylase kinase alpha 2	Mus musculus	194-197
16335803-7	2005	However, induction of apoptosis with staurosporine, also a potent PhK inhibitor, led to a rapid loss in phosphorylase activity and intracellular ATP, suggesting that PhK inhibition by staurosporine impairs the ability of apoptotic muscle cells to generate ATP.	Staurosporine	37-50	phosphorylase kinase alpha 2	Mus musculus	66-69
16335803-7	2005	However, induction of apoptosis with staurosporine, also a potent PhK inhibitor, led to a rapid loss in phosphorylase activity and intracellular ATP, suggesting that PhK inhibition by staurosporine impairs the ability of apoptotic muscle cells to generate ATP.	Staurosporine	37-50	phosphorylase kinase alpha 2	Mus musculus	166-169
16335803-7	2005	However, induction of apoptosis with staurosporine, also a potent PhK inhibitor, led to a rapid loss in phosphorylase activity and intracellular ATP, suggesting that PhK inhibition by staurosporine impairs the ability of apoptotic muscle cells to generate ATP.	Staurosporine	184-197	phosphorylase kinase alpha 2	Mus musculus	66-69
16335803-7	2005	However, induction of apoptosis with staurosporine, also a potent PhK inhibitor, led to a rapid loss in phosphorylase activity and intracellular ATP, suggesting that PhK inhibition by staurosporine impairs the ability of apoptotic muscle cells to generate ATP.	Staurosporine	184-197	phosphorylase kinase alpha 2	Mus musculus	166-169
15814533-13	2005	The GDP-induced VEGF and transforming growth factor (TGF)-beta synthesis in HPMC was partially reduced by either the p42/p44 MAPK inhibitor (PD98059) or the PKC inhibitor (staurosporine).	Staurosporine	172-185	vascular endothelial growth factor A	Homo sapiens	16-20
15814533-13	2005	The GDP-induced VEGF and transforming growth factor (TGF)-beta synthesis in HPMC was partially reduced by either the p42/p44 MAPK inhibitor (PD98059) or the PKC inhibitor (staurosporine).	Staurosporine	172-185	transforming growth factor beta 1	Homo sapiens	53-56
15688372-4	2005	Overexpression of FAF1 enhanced DEF assembly and cell death induced by chemotherapeutics such as staurosporine (STS), cisplatin (CDDP) and etoposide (VP16).	Staurosporine	97-110	Fas associated factor 1	Homo sapiens	18-22
15688372-4	2005	Overexpression of FAF1 enhanced DEF assembly and cell death induced by chemotherapeutics such as staurosporine (STS), cisplatin (CDDP) and etoposide (VP16).	Staurosporine	112-115	Fas associated factor 1	Homo sapiens	18-22
15911217-0	2005	Effect of staurosporine on N-glycosylation and cell adhesion to fibronectin of SW480 human colorectal adenocarcinoma cells.	Staurosporine	10-23	fibronectin 1	Homo sapiens	64-75
15870902-4	2005	Beta-catenin cleavage products of the same electrophoretic mobility were detected in G401 cells after induction of apoptosis with staurosporine and cell cycle arrest by aphidicolin.	Staurosporine	130-143	catenin beta 1	Homo sapiens	0-12
15912144-8	2005	Coincubation of tyrphostins with staurosporine was accompanied by rapid complete inhibition of STAT3 phosphorylation.	Staurosporine	33-46	signal transducer and activator of transcription 3	Homo sapiens	95-100
15907209-10	2005	RESULTS: We report that maspin expressing tumor cells have increased rate of apoptosis when they are treated with staurosporine and serum starvation.	Staurosporine	114-127	serine (or cysteine) peptidase inhibitor, clade B, member 5	Mus musculus	24-30
15767261-3	2005	We show here that the antiapoptotic activity of the AR/IGF1 combination is specifically abolished by the PKC inhibitors calphostin C and staurosporine, but not by the MAPK and phosphatidylinositol 3-kinase inhibitors PD98059 and wortmannin, suggesting the involvement of a PKC-dependent and MAPK- and phosphatidylinositol 3-kinase-independent survival pathway.	Staurosporine	137-150	amphiregulin	Homo sapiens	52-54
15767261-3	2005	We show here that the antiapoptotic activity of the AR/IGF1 combination is specifically abolished by the PKC inhibitors calphostin C and staurosporine, but not by the MAPK and phosphatidylinositol 3-kinase inhibitors PD98059 and wortmannin, suggesting the involvement of a PKC-dependent and MAPK- and phosphatidylinositol 3-kinase-independent survival pathway.	Staurosporine	137-150	insulin like growth factor 1	Homo sapiens	55-59
15767261-3	2005	We show here that the antiapoptotic activity of the AR/IGF1 combination is specifically abolished by the PKC inhibitors calphostin C and staurosporine, but not by the MAPK and phosphatidylinositol 3-kinase inhibitors PD98059 and wortmannin, suggesting the involvement of a PKC-dependent and MAPK- and phosphatidylinositol 3-kinase-independent survival pathway.	Staurosporine	137-150	protein kinase C delta	Homo sapiens	105-108
15721486-6	2005	AngII-induced VSMC proliferation and activation of ERK1/2 and nuclear transcription factor Elk-1 were all down-regulated by PKC non-specific inhibitor (staurosporine) and PKCzeta pseudosubstrate inhibitor (PS-PKCzeta).	Staurosporine	152-165	angiotensinogen	Rattus norvegicus	0-5
15721486-6	2005	AngII-induced VSMC proliferation and activation of ERK1/2 and nuclear transcription factor Elk-1 were all down-regulated by PKC non-specific inhibitor (staurosporine) and PKCzeta pseudosubstrate inhibitor (PS-PKCzeta).	Staurosporine	152-165	mitogen activated protein kinase 3	Rattus norvegicus	51-57
15721486-6	2005	AngII-induced VSMC proliferation and activation of ERK1/2 and nuclear transcription factor Elk-1 were all down-regulated by PKC non-specific inhibitor (staurosporine) and PKCzeta pseudosubstrate inhibitor (PS-PKCzeta).	Staurosporine	152-165	ETS transcription factor ELK1	Rattus norvegicus	91-96
15909115-3	2005	In this study, we examined the involvement of Akt/PKB and its upstream kinase, PDK1 and whether JNK activation correlated with human and rat VSMC apoptosis induced by staurosporine and by c-myc, respectively.	Staurosporine	167-180	mitogen-activated protein kinase 8	Homo sapiens	96-99
15870872-0	2005	Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK.	Staurosporine	41-54	mitogen-activated protein kinase 8	Homo sapiens	110-113
15870872-0	2005	Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK.	Staurosporine	41-54	mitogen-activated protein kinase 14	Homo sapiens	133-136
15870872-6	2005	With phosphorylation-specific Western blotting and protein kinase assays, it was demonstrated that staurosporine suppresses the phosphorylation of p38 and activates JNK.	Staurosporine	99-112	mitogen-activated protein kinase 14	Homo sapiens	147-150
15870872-6	2005	With phosphorylation-specific Western blotting and protein kinase assays, it was demonstrated that staurosporine suppresses the phosphorylation of p38 and activates JNK.	Staurosporine	99-112	mitogen-activated protein kinase 8	Homo sapiens	165-168
15870872-7	2005	These results suggest that p38MAPK and JNK signal transduction pathways were involved in the regulation of granulosa cell differentiation by staurosporine.	Staurosporine	141-154	mitogen-activated protein kinase 8	Homo sapiens	39-42
15786489-9	2005	The presence of staurosporine (10(-8) M) caused a significant decrease in regucalcin mRNA expression.	Staurosporine	16-29	regucalcin	Rattus norvegicus	74-84
16019536-3	2005	We now report that a staurosporine derivative, N-benzoylated staurosporine or PKC412, induces cell death in myeloma cell lines (RPMI8226S, U266, MM1S and MM1R) with loss of mitochondrial membrane potential Delta psi m, caspase 3 and PARP cleavage.	Staurosporine	21-34	caspase 3	Homo sapiens	219-228
16019536-3	2005	We now report that a staurosporine derivative, N-benzoylated staurosporine or PKC412, induces cell death in myeloma cell lines (RPMI8226S, U266, MM1S and MM1R) with loss of mitochondrial membrane potential Delta psi m, caspase 3 and PARP cleavage.	Staurosporine	21-34	collagen type XI alpha 2 chain	Homo sapiens	233-237
16019536-3	2005	We now report that a staurosporine derivative, N-benzoylated staurosporine or PKC412, induces cell death in myeloma cell lines (RPMI8226S, U266, MM1S and MM1R) with loss of mitochondrial membrane potential Delta psi m, caspase 3 and PARP cleavage.	Staurosporine	61-74	caspase 3	Homo sapiens	219-228
16019536-3	2005	We now report that a staurosporine derivative, N-benzoylated staurosporine or PKC412, induces cell death in myeloma cell lines (RPMI8226S, U266, MM1S and MM1R) with loss of mitochondrial membrane potential Delta psi m, caspase 3 and PARP cleavage.	Staurosporine	61-74	collagen type XI alpha 2 chain	Homo sapiens	233-237
15692060-4	2005	Enforced expression of Apaf-1 increased its concentration in the cytosolic compartment, restored cytochrome c-dependent caspase activation, and rendered the prototypic Raji BL cell line sensitive to etoposide- and staurosporine-induced apoptosis.	Staurosporine	214-227	apoptotic peptidase activating factor 1	Homo sapiens	23-29
15857611-6	2005	Although transcription of the SNK gene was also regulated by tunicamycin, etoposide, or staurosporine, FK506 did not show any effects on these regulations.	Staurosporine	88-101	polo like kinase 2	Homo sapiens	30-33
15909127-6	2005	Both H(2)O(2) and staurosporine increased DNA fragmentation and caspase-3 activity and pre-treatment of cells with alpha -lipoic acid and/or alpha -tocopherol failed to prevent stress-induced apoptosis.	Staurosporine	18-31	caspase 3	Homo sapiens	64-73
15709112-4	2005	This redistribution was inhibited by staurosporine, a pan PKC inhibitor, or by 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole (Go6976) at a concentration that selectively inhibits conventional PKC isozymes (PKC alpha, -beta, and -gamma).	Staurosporine	37-50	protein kinase C, alpha	Rattus norvegicus	58-61
15854039-8	2005	Apoptosis of cultured normal human keratinocytes, which was induced by staurosporine, resulted in a concentration-dependent decrease in levels of SCF mRNA and protein.	Staurosporine	71-84	KIT ligand	Homo sapiens	146-149
15772159-4	2005	Bax is a component of MAC of staurosporine-treated HeLa cells because MAC activity is immunodepleted by Bax antibodies.	Staurosporine	29-42	BCL2 associated X, apoptosis regulator	Homo sapiens	0-3
15772159-4	2005	Bax is a component of MAC of staurosporine-treated HeLa cells because MAC activity is immunodepleted by Bax antibodies.	Staurosporine	29-42	BCL2 associated X, apoptosis regulator	Homo sapiens	104-107
15772159-10	2005	These findings indicate Bax is a component of MAC in staurosporine-treated HeLa cells and suggest Bax and Bak are functionally redundant as components of MAC.	Staurosporine	53-66	BCL2 associated X, apoptosis regulator	Homo sapiens	24-27
15896354-9	2005	Furthermore, PEDF increased protein kinase C (PKC) activity in pericytes and staurosporine, a potent cell-permeable inhibitor of PKC, completely blocked the PDGF-B gene induction and subsequent increase in DNA synthesis in PEDF-exposed pericytes.	Staurosporine	77-90	platelet derived growth factor subunit B	Homo sapiens	157-163
15896354-9	2005	Furthermore, PEDF increased protein kinase C (PKC) activity in pericytes and staurosporine, a potent cell-permeable inhibitor of PKC, completely blocked the PDGF-B gene induction and subsequent increase in DNA synthesis in PEDF-exposed pericytes.	Staurosporine	77-90	serpin family F member 1	Homo sapiens	223-227
15680481-6	2005	Both the phospholipase C (PLC) inhibitor U-73122 (10(-6) M) and the inhibitor of protein kinase C (PKC) staurosporine (10(-7) M) prevent inhibition of the Ca2+ pump by Ang II.	Staurosporine	104-117	angiotensinogen	Homo sapiens	168-174
15773895-8	2005	Furthermore, both SIRT1- and SIRT2-deficient cells were more sensitive to pro-apoptotic stimuli including cisplatin and staurosporine.	Staurosporine	120-133	sirtuin 1	Gallus gallus	18-23
15888248-11	2005	The blockade of P2Y1 or CysLT1/CysLT2 receptors by specific antagonists that abolished the raise in [Ca2+]i and drastically reduced the concomitant efflux of both compounds, as well as the effects of BAPTA and staurosporine support this hypothesis.	Staurosporine	210-223	cysteinyl leukotriene receptor 2	Rattus norvegicus	31-37
15816862-4	2005	In the present study, we determined whether Epo pre-treatment protects neonatal rat astrocytes from apoptotic cell death resulting from treatment with nitric oxide, staurosporine (STS) and arsenic trioxide and possible mechanisms mediating Epo-related cytoprotection.	Staurosporine	165-178	erythropoietin	Rattus norvegicus	44-47
15816862-4	2005	In the present study, we determined whether Epo pre-treatment protects neonatal rat astrocytes from apoptotic cell death resulting from treatment with nitric oxide, staurosporine (STS) and arsenic trioxide and possible mechanisms mediating Epo-related cytoprotection.	Staurosporine	180-183	erythropoietin	Rattus norvegicus	44-47
15756452-5	2005	Staurosporine treatment determined the apoptosis of 35 and 33% respectively of MDA MB 231 and MCF7; these values increased to 60 and 64% in cells plated on laminin, to 48 and 63% in cells plated on fibronectin and to 64 and 69% in cells plated on matrigel.	Staurosporine	0-13	fibronectin 1	Homo sapiens	198-209
15756452-6	2005	Moreover, staurosporine treatment decreased bcl-2 expression in the cells plated on fibronectin and laminin.	Staurosporine	10-23	BCL2 apoptosis regulator	Homo sapiens	44-49
15756452-6	2005	Moreover, staurosporine treatment decreased bcl-2 expression in the cells plated on fibronectin and laminin.	Staurosporine	10-23	fibronectin 1	Homo sapiens	84-95
15756452-7	2005	Yet, staurosporine treatment determined PARP cleavage and PARP partial disappearance when the cells were plated on matrigel.	Staurosporine	5-18	collagen type XI alpha 2 chain	Homo sapiens	40-44
15756452-7	2005	Yet, staurosporine treatment determined PARP cleavage and PARP partial disappearance when the cells were plated on matrigel.	Staurosporine	5-18	collagen type XI alpha 2 chain	Homo sapiens	58-62
15660100-5	2005	We found that NO donors ((+/-)-S-nitroso-N-acetylpenicillamine, S-nitrosoglutathione, and NONOates) dose-dependently inhibited caspase-3 and -9 activity induced by STS and camptothecin.	Staurosporine	164-167	caspase 3	Homo sapiens	127-143
15494549-8	2005	The protective effect of TPA on CYP2E1-dependent AA + Fe toxicity seemed to involve a PKC-related survival mechanism, since PKC inhibitors such as Ro 31-8425 (bisindolylmaleimide X hydrochloride) or staurosporine abolished that protection, and activation of PKC by TPA was an early event that occurs prior to the developing toxicity.	Staurosporine	199-212	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	32-38
15709158-10	2005	Immunohistochemistry studies showed that the Smac/DIABLO protein localized in mitochondria and was released into the cytosol in both fragmented embryos and embryos in which apoptosis was induced by staurosporine.	Staurosporine	198-211	diablo, IAP-binding mitochondrial protein	Mus musculus	45-49
15709158-10	2005	Immunohistochemistry studies showed that the Smac/DIABLO protein localized in mitochondria and was released into the cytosol in both fragmented embryos and embryos in which apoptosis was induced by staurosporine.	Staurosporine	198-211	diablo, IAP-binding mitochondrial protein	Mus musculus	50-56
15671158-6	2005	In agreement with the cardioprotective effect observed in vivo, staurosporine-induced apoptosis of adult rat or mouse cardiomyocytes in vitro was also significantly attenuated ( approximately 35%) by CEPO, which is comparable with the effect of EPO.	Staurosporine	64-77	erythropoietin	Mus musculus	201-204
15680335-20	2005	Brief hypoxia induced facilitation of the respiratory activity, which was prevented after blockade of mK(ATP) channels with 5-HD and PKC with staurosporine.	Staurosporine	142-155	ATPase phospholipid transporting 8A2	Homo sapiens	105-108
15811333-0	2005	Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins.	Staurosporine	55-67	cystatin B	Mus musculus	17-25
15811333-3	2005	We have observed increased sensibility to STS-induced apoptosis in the thymocytes of stefin B-deficient mice.	Staurosporine	42-45	cystatin B	Mus musculus	85-93
15657054-5	2005	The crystal structures of Pim-1 complexed with staurosporine and adenosine were determined.	Staurosporine	47-60	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	26-31
16874023-9	2005	Moreover, transition of EGFP-LC3-I (45 kDa) to EGFP-LC3-II (43 kDa)-traced by immunoblotting and verified by [(3)H]ethanolamine labelling-revealed novel insights into the dynamics of autophagosome homeostasis, including the rapid activation of autophagy by the apoptotic inducer staurosporine prior to apoptosis proper.	Staurosporine	279-292	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	29-32
16874023-9	2005	Moreover, transition of EGFP-LC3-I (45 kDa) to EGFP-LC3-II (43 kDa)-traced by immunoblotting and verified by [(3)H]ethanolamine labelling-revealed novel insights into the dynamics of autophagosome homeostasis, including the rapid activation of autophagy by the apoptotic inducer staurosporine prior to apoptosis proper.	Staurosporine	279-292	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	52-55
15493013-4	2005	We found that M059K cells were much more sensitive to staurosporine (STS) treatment than M059J cells, as demonstrated by MTT assay, TUNEL detection, and annexin-V and propidium iodide (PI) staining.	Staurosporine	54-67	annexin A5	Homo sapiens	153-162
15632189-6	2005	Membrane-permeable DAG (dioctanoylglycerol) also induced DGK translocation but in a PKC (staurosporin)-independent fashion.	Staurosporine	89-101	diacylglycerol kinase beta	Homo sapiens	57-60
15767461-6	2005	Nucleocytoplasmic shuttling of HDAC4-GFP in unstimulated resting fibers was not altered by KN-62, but was blocked by staurosporine, indicating that different kinases underlie nuclear efflux of HDAC4 in resting and stimulated muscle fibers.	Staurosporine	117-130	histone deacetylase 4	Homo sapiens	31-36
15767461-6	2005	Nucleocytoplasmic shuttling of HDAC4-GFP in unstimulated resting fibers was not altered by KN-62, but was blocked by staurosporine, indicating that different kinases underlie nuclear efflux of HDAC4 in resting and stimulated muscle fibers.	Staurosporine	117-130	histone deacetylase 4	Homo sapiens	193-198
15760676-6	2005	We also observed that in our experimental conditions, staurosporine, an inhibitor of both PKC and PMA-stimulated cellular responses, does not involve PKC inhibition in irradiated cells and significantly decreased NF-kappa B activity in response to UVB radiation.	Staurosporine	54-67	nuclear factor kappa B subunit 1	Homo sapiens	213-223
15626483-8	2005	Strikingly, stimulation with CpG-DNA resulted in a strongly increased sensitivity of TLR9-expressing fibroblasts to apoptosis induced by staurosporine and UV-irradiation.	Staurosporine	137-150	toll like receptor 9	Homo sapiens	85-89
15740647-6	2005	Simultaneously, the PKC inhibitor staurosporine blocked the upregulation of phosphorylated JNK and phosphorylated p38, but had little effect on extracellular signal-regulated kinase (ERK) expression.	Staurosporine	34-47	mitogen-activated protein kinase 8	Homo sapiens	91-94
15740647-6	2005	Simultaneously, the PKC inhibitor staurosporine blocked the upregulation of phosphorylated JNK and phosphorylated p38, but had little effect on extracellular signal-regulated kinase (ERK) expression.	Staurosporine	34-47	mitogen-activated protein kinase 1	Homo sapiens	114-117
15798397-9	2005	Staurosporine inhibited GST-MKK4 with an IC50 of 70 nM.	Staurosporine	0-13	glutathione S-transferase kappa 1	Homo sapiens	24-27
15798397-9	2005	Staurosporine inhibited GST-MKK4 with an IC50 of 70 nM.	Staurosporine	0-13	mitogen-activated protein kinase kinase 4	Homo sapiens	28-32
15542537-9	2005	Thus 0.4MAC increased PKCepsilon phosphorylation, and this effect was blocked by staurosporine.	Staurosporine	81-94	protein kinase C, epsilon	Rattus norvegicus	22-32
15639483-0	2005	alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism.	Staurosporine	83-96	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	0-7
15639483-12	2005	Staurosporine, but not chelerythrine, completely reversed the preconditioning effect of CAM alpha1A-ARs.	Staurosporine	0-13	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	92-99
15639483-13	2005	CONCLUSIONS: These data demonstrate that alpha1A-ARs protect the heart from ischemic injury through a staurosporine-sensitive signaling pathway that is independent of protein kinase C.	Staurosporine	102-115	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	Mus musculus	41-48
15709112-4	2005	This redistribution was inhibited by staurosporine, a pan PKC inhibitor, or by 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole (Go6976) at a concentration that selectively inhibits conventional PKC isozymes (PKC alpha, -beta, and -gamma).	Staurosporine	37-50	protein kinase C, alpha	Rattus norvegicus	242-245
15709112-4	2005	This redistribution was inhibited by staurosporine, a pan PKC inhibitor, or by 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole (Go6976) at a concentration that selectively inhibits conventional PKC isozymes (PKC alpha, -beta, and -gamma).	Staurosporine	37-50	protein kinase C, alpha	Rattus norvegicus	256-284
15474986-5	2005	It was observed that Staurosporine, a Ser/Thr kinase inhibitor, blocked the Ser15 phosphorylation of p53 and the hPCNA promoter response to 4-NQO simultaneously, suggesting that Ser15 phosphorylated p53 was the 4-NQO-responsive hPCNA regulator.	Staurosporine	21-34	tumor protein p53	Homo sapiens	101-104
15787696-7	2005	Consistent with the presence of a nonfunctional form of KCC2 in immature hippocampal neurons grown in culture, application of the broad-spectrum kinase inhibitor staurosporine produces a rapid and potent up-regulation of KCC2 function in these cultured neurons, but not in neonatal slices.	Staurosporine	162-175	solute carrier family 12, member 5	Mus musculus	56-60
15787696-7	2005	Consistent with the presence of a nonfunctional form of KCC2 in immature hippocampal neurons grown in culture, application of the broad-spectrum kinase inhibitor staurosporine produces a rapid and potent up-regulation of KCC2 function in these cultured neurons, but not in neonatal slices.	Staurosporine	162-175	solute carrier family 12, member 5	Mus musculus	221-225
15787696-8	2005	Taken together with our previously published data, these results indicate that the functional activity of KCC2 in vivo parallels the developmental expression of the protein, whereas cultured neurons require an additional activation step (mimicked by staurosporine) for KCC2 to become functional.	Staurosporine	250-263	solute carrier family 12, member 5	Mus musculus	269-273
15474986-5	2005	It was observed that Staurosporine, a Ser/Thr kinase inhibitor, blocked the Ser15 phosphorylation of p53 and the hPCNA promoter response to 4-NQO simultaneously, suggesting that Ser15 phosphorylated p53 was the 4-NQO-responsive hPCNA regulator.	Staurosporine	21-34	proliferating cell nuclear antigen	Homo sapiens	113-118
15474986-5	2005	It was observed that Staurosporine, a Ser/Thr kinase inhibitor, blocked the Ser15 phosphorylation of p53 and the hPCNA promoter response to 4-NQO simultaneously, suggesting that Ser15 phosphorylated p53 was the 4-NQO-responsive hPCNA regulator.	Staurosporine	21-34	tumor protein p53	Homo sapiens	199-202
15474986-5	2005	It was observed that Staurosporine, a Ser/Thr kinase inhibitor, blocked the Ser15 phosphorylation of p53 and the hPCNA promoter response to 4-NQO simultaneously, suggesting that Ser15 phosphorylated p53 was the 4-NQO-responsive hPCNA regulator.	Staurosporine	21-34	proliferating cell nuclear antigen	Homo sapiens	228-233
15316934-2	2005	Expression of the WT, but not of the mutant, caspase-3 was associated with increased caspase activity and susceptibility to staurosporine (STS)-induced apoptosis.	Staurosporine	124-137	caspase 3	Homo sapiens	45-54
15642369-2	2005	To clarify its target, staurosporine-induced activation of caspase-3, DNA laddering and cell death were examined in cultured rat cardiomyocytes.	Staurosporine	23-36	caspase 3	Rattus norvegicus	59-68
15665074-4	2005	A cell permeant peptide derived from this sequence displaces cytochrome c from IP3R and abrogates cell death induced by staurosporine treatment of HeLa cells and Fas ligand stimulation of Jurkat cells.	Staurosporine	120-133	cytochrome c, somatic	Homo sapiens	61-73
15665074-4	2005	A cell permeant peptide derived from this sequence displaces cytochrome c from IP3R and abrogates cell death induced by staurosporine treatment of HeLa cells and Fas ligand stimulation of Jurkat cells.	Staurosporine	120-133	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	79-83
15665077-7	2005	However, staurosporine (a broad spectrum PK inhibitor), bisindolylmaleimide I (a PKC inhibitor), and U73122 (a phospholipase C inhibitor) blocked the BDNF-induced effects on the epileptic GABA currents.	Staurosporine	9-22	brain derived neurotrophic factor	Homo sapiens	150-154
15984158-7	2005	Aurora-A was not found in the spindle region when colchicine or staurosporine was used to inhibit microtubule organization, while it accumulated as several dots in the cytoplasm after taxol treatment.	Staurosporine	64-77	aurora kinase A	Homo sapiens	0-8
15522882-6	2005	Attachment to the RGDS-treated membrane completely abolished apoptosis induced by staurosporine, the Ca(2+).P(i) ion pair, and sodium nitroprusside.	Staurosporine	82-95	ral guanine nucleotide dissociation stimulator	Mus musculus	18-22
15582661-0	2005	The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine.	Staurosporine	165-178	serine/threonine protein kinase US3	Suid alphaherpesvirus 1	23-26
15582661-3	2005	Here, we demonstrate that US3 of the swine alphaherpesvirus pseudorabies virus (PRV) suppresses PRV-induced apoptosis in swine-testicle (ST) cells at late stages in infection, and that it protects ST cells from apoptosis induced by either sorbitol or staurosporine.	Staurosporine	251-264	serine/threonine protein kinase US3	Suid alphaherpesvirus 1	26-29
15582661-5	2005	Transient transfections showed that the PRV US3 long isoform is more efficient in protecting ST cells from PRV- or staurosporine-induced apoptosis, suggesting a potential advantage for the mitochondrial localization of PRV US3 in implementing its anti-apoptotic function.	Staurosporine	115-128	serine/threonine protein kinase US3	Suid alphaherpesvirus 1	44-47
15582661-5	2005	Transient transfections showed that the PRV US3 long isoform is more efficient in protecting ST cells from PRV- or staurosporine-induced apoptosis, suggesting a potential advantage for the mitochondrial localization of PRV US3 in implementing its anti-apoptotic function.	Staurosporine	115-128	serine/threonine protein kinase US3	Suid alphaherpesvirus 1	223-226
16207329-10	2005	The treatment with staurosporine (enhancer of apoptosis) induced decreased NF-kappaB DNA binding in all conditions, but particularly in testosterone-treated THP-1 cells.	Staurosporine	19-32	nuclear factor kappa B subunit 1	Homo sapiens	75-84
16037691-3	2005	To clarify whether Cl-/HCO3- exchangers or Cl- channels are targets of DIDS and whether ClC-3 is involved in the apoptotic process, staurosporine-induced reduction of cell viability, DNA laddering and caspase-3 activation were examined in cultured mouse ventricular myocytes derived from wild-type and ClC-3-deficient mice.	Staurosporine	132-145	chloride channel, voltage-sensitive 3	Mus musculus	88-93
16037691-3	2005	To clarify whether Cl-/HCO3- exchangers or Cl- channels are targets of DIDS and whether ClC-3 is involved in the apoptotic process, staurosporine-induced reduction of cell viability, DNA laddering and caspase-3 activation were examined in cultured mouse ventricular myocytes derived from wild-type and ClC-3-deficient mice.	Staurosporine	132-145	caspase 3	Mus musculus	201-210
16037691-3	2005	To clarify whether Cl-/HCO3- exchangers or Cl- channels are targets of DIDS and whether ClC-3 is involved in the apoptotic process, staurosporine-induced reduction of cell viability, DNA laddering and caspase-3 activation were examined in cultured mouse ventricular myocytes derived from wild-type and ClC-3-deficient mice.	Staurosporine	132-145	chloride channel, voltage-sensitive 3	Mus musculus	302-307
16037691-6	2005	Cardiomyocytes derived from ClC-3-deficient mice similarly underwent apoptosis after exposure to staurosporine; moreover, apoptosis was prevented by application of DIDS or NPPB.	Staurosporine	97-110	chloride channel, voltage-sensitive 3	Mus musculus	28-33
15589523-6	2005	When the isolated myofibers were incubated with the kinase inhibitor staurosporine, the ClC-1 protein shifted back to the sarcolemma.	Staurosporine	69-82	chloride voltage-gated channel 1	Homo sapiens	88-93
15547953-10	2005	Interestingly, the mutated egg chambers are protected by staurosporine-induced apoptosis in a percentage of 40%, strongly suggesting the essential role of dcp-1 and/or pita during mid-oogenesis.	Staurosporine	57-70	Death caspase-1	Drosophila melanogaster	155-160
15547953-10	2005	Interestingly, the mutated egg chambers are protected by staurosporine-induced apoptosis in a percentage of 40%, strongly suggesting the essential role of dcp-1 and/or pita during mid-oogenesis.	Staurosporine	57-70	pita	Drosophila melanogaster	168-172
16301820-6	2005	However, blockade of Smad2 signaling pathway by Staurosporine did not affect the TGFbeta1-stimulated secretion of MMP-9, whereas inhibition of activation of ERK1/2 by PD98059 abolished TGFbeta1-stimulated secretion of MMP-9 and expression of MMP-9 mRNA.	Staurosporine	48-61	SMAD family member 2	Mus musculus	21-26
16207329-10	2005	The treatment with staurosporine (enhancer of apoptosis) induced decreased NF-kappaB DNA binding in all conditions, but particularly in testosterone-treated THP-1 cells.	Staurosporine	19-32	GLI family zinc finger 2	Homo sapiens	157-162
15475565-9	2004	Prior tau dephosphorylation by a glycogen synthase kinase-3beta inhibitor, lithium, enhanced tau cleavage and sensitized neurons to staurosporine-induced apoptosis.	Staurosporine	132-145	microtubule associated protein tau	Homo sapiens	6-9
15498771-1	2004	When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation.	Staurosporine	69-82	H2A.X variant histone	Homo sapiens	180-184
15498771-1	2004	When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation.	Staurosporine	69-82	checkpoint kinase 2	Homo sapiens	186-190
15498771-1	2004	When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation.	Staurosporine	69-82	tumor protein p53	Homo sapiens	196-199
15498771-1	2004	When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation.	Staurosporine	84-87	H2A.X variant histone	Homo sapiens	180-184
15498771-1	2004	When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation.	Staurosporine	84-87	checkpoint kinase 2	Homo sapiens	186-190
15498771-1	2004	When added for a short period (2-4 h) to cells, the kinase inhibitor staurosporine (STS), can trigger double strand breaks, the formation of nuclear foci containing phosphorylated H2AX, Chk2, and p53, a decrease in transcription, and a minor degree of peripheral chromatin condensation.	Staurosporine	84-87	tumor protein p53	Homo sapiens	196-199
15613975-0	2005	Staurosporine promotes endothelial cell assembly and FAK phosphorylation during in vitro angiogenesis.	Staurosporine	0-13	protein tyrosine kinase 2	Homo sapiens	53-56
15613975-9	2005	Further investigation showed that inhibition of PI-3 kinase and Raf-1 significantly reduced the effects of staurosporine.	Staurosporine	107-120	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	64-69
15613975-10	2005	Staurosporine-induced in vitro angiogenesis required integrins alpha2 and alphavbeta3 and was associated with significantly enhanced FAK phosphorylation.	Staurosporine	0-13	protein tyrosine kinase 2	Homo sapiens	133-136
15613975-12	2005	The data suggest that enhancement of in vitro angiogenesis by staurosporine involves integrin-mediated signaling, including the stimulation of FAK phosphorylation.	Staurosporine	62-75	protein tyrosine kinase 2	Homo sapiens	143-146
16416674-0	2005	c-Abl is required for staurosporine-induced caspase activity.	Staurosporine	22-35	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-5
16416674-6	2005	Here, we report c-Abl dependent caspase-3 and caspase-8 activity in response to staurosporine.	Staurosporine	80-93	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	16-21
16416674-6	2005	Here, we report c-Abl dependent caspase-3 and caspase-8 activity in response to staurosporine.	Staurosporine	80-93	caspase 3	Homo sapiens	32-41
16416674-6	2005	Here, we report c-Abl dependent caspase-3 and caspase-8 activity in response to staurosporine.	Staurosporine	80-93	caspase 8	Homo sapiens	46-55
15507431-9	2004	Finally, the Syk-bound cis-conformation of Gleevec bears a striking resemblance to the rigid structure of the nonspecific, natural product kinase inhibitor staurosporine.	Staurosporine	156-169	spleen associated tyrosine kinase	Homo sapiens	13-16
15475565-9	2004	Prior tau dephosphorylation by a glycogen synthase kinase-3beta inhibitor, lithium, enhanced tau cleavage and sensitized neurons to staurosporine-induced apoptosis.	Staurosporine	132-145	glycogen synthase kinase 3 beta	Homo sapiens	33-63
15669141-2	2004	Regarding the antiapoptotic mechanisms, we have previously demonstrated that under staurosporine treatment, HalphaA- and HalphaB-crystallins can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family, to sequester their translocation into mitochondria, and thus prevent the staurosporine-induced apoptosis.	Staurosporine	83-96	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
15601544-0	2004	[Translocation of orphan receptor TR3 from nuclei to mitochondria induced by staurosporine].	Staurosporine	77-90	nuclear receptor subfamily 4 group A member 1	Homo sapiens	34-37
15601544-4	2004	This study was to investigate the mechanism by which STS induces apoptosis of gastric cancer cell line BGC-823,and its correlation with translocation of TR3 in BGC-823 cells.	Staurosporine	53-56	nuclear receptor subfamily 4 group A member 1	Homo sapiens	153-156
15344906-3	2004	During staurosporine-, Fas- and tumour necrosis factor a-induced apoptosis, CDK11p110, is cleaved by caspases to generate smaller 46-50 kDa proteins containing the catalytic kinase domain.	Staurosporine	7-20	cyclin dependent kinase 11A	Homo sapiens	76-85
15669141-2	2004	Regarding the antiapoptotic mechanisms, we have previously demonstrated that under staurosporine treatment, HalphaA- and HalphaB-crystallins can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family, to sequester their translocation into mitochondria, and thus prevent the staurosporine-induced apoptosis.	Staurosporine	290-303	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
15599843-4	2004	The hypoxia-induced HO-1 expression was blocked by the kinase inhibitors staurosporine and SB202190 in a dose-dependent manner.	Staurosporine	73-86	heme oxygenase 1	Rattus norvegicus	20-24
15599843-9	2004	The HO-1 promoter activity was modulated by OA under normoxic conditions or staurosporine under hypoxia.	Staurosporine	76-89	heme oxygenase 1	Rattus norvegicus	4-8
15364937-8	2004	The PKC-staurosporine complex represents the first kinase domain crystal structure of any PKC isotypes to be determined and as such should provide valuable insight into PKC specificity and into rational drug design strategies for PKC selective leads.	Staurosporine	8-21	protein kinase C theta	Homo sapiens	4-7
15579770-7	2004	TSHr signal transduction was evaluated by analyzing the effect of stimulators (cholera toxin, 8-bromo-cAMP, forskolin, and 12-O-tetradecanoyl-phorbol-13-acetate) and inhibitors (2",5"-dideoxyadenosine and staurosporine) on VEGF protein levels under basal and TSH-stimulated conditions.	Staurosporine	205-218	thyroid stimulating hormone receptor	Rattus norvegicus	0-4
15579770-9	2004	The effects of TSH were mediated by protein kinase C (PKC), rather than protein kinase A (PKA), stimulation, because inhibition of PKC by staurosporine resulted in a decrease in VEGF production of up to 65%, whereas inhibition of the PKA signal transduction pathway (2",5"-dideoxyadenosine) resulted in only a minor decrease.	Staurosporine	138-151	vascular endothelial growth factor A	Rattus norvegicus	178-182
15364937-8	2004	The PKC-staurosporine complex represents the first kinase domain crystal structure of any PKC isotypes to be determined and as such should provide valuable insight into PKC specificity and into rational drug design strategies for PKC selective leads.	Staurosporine	8-21	protein kinase C theta	Homo sapiens	90-93
15364937-8	2004	The PKC-staurosporine complex represents the first kinase domain crystal structure of any PKC isotypes to be determined and as such should provide valuable insight into PKC specificity and into rational drug design strategies for PKC selective leads.	Staurosporine	8-21	protein kinase C theta	Homo sapiens	90-93
15364937-8	2004	The PKC-staurosporine complex represents the first kinase domain crystal structure of any PKC isotypes to be determined and as such should provide valuable insight into PKC specificity and into rational drug design strategies for PKC selective leads.	Staurosporine	8-21	protein kinase C theta	Homo sapiens	90-93
15522829-6	2004	Treatment with inhibitors (AACOCF(3), staurosporine and cycloheximide) resulted in a sharp decrease in basal and stimulated cPLA(2) activity.	Staurosporine	38-51	phospholipase A2 group IVA	Bos taurus	124-131
15474551-11	2004	The protein kinase C inhibitor staurosporine abolished these stimulatory effects of gastrin and IL-1beta.	Staurosporine	31-44	gastrin	Oryctolagus cuniculus	84-91
15474551-11	2004	The protein kinase C inhibitor staurosporine abolished these stimulatory effects of gastrin and IL-1beta.	Staurosporine	31-44	interleukin-1 beta	Oryctolagus cuniculus	96-104
15251861-7	2004	The pressor effect of ANG II was blunted (P &lt; 0.05) in kidneys perfused with buffer containing losartan (10 micromol/l) or PKC inhibitors staurosporine (0.1 micromol/l) or calphostin C (1 micromol/l).	Staurosporine	141-154	angiotensinogen	Rattus norvegicus	22-28
15229106-9	2004	Go6976, an inhibitor of classical PKC isoforms, caused a significant inhibition of fMLP-induced elastase release in the presence or absence of fibrinogen, while nonselective inhibitors of PKC, Ro 31-8220, GF-109203X, and staurosporine, caused potentiation of fMLP-induced elastase release.	Staurosporine	221-234	formyl peptide receptor 1	Homo sapiens	83-87
15242874-7	2004	BLIN-4L cells made deficient in caspase-9 by RNA interference exhibited no resistance to apoptotic signals and actually showed increased apoptotic sensitivity to staurosporine.	Staurosporine	162-175	caspase 9	Homo sapiens	32-41
15280382-4	2004	Depletion of Prx III resulted in increased intracellular levels of H(2)O(2) and sensitized cells to induction of apoptosis by staurosporine or TNF-alpha.	Staurosporine	126-139	peroxiredoxin 3	Homo sapiens	13-20
15500642-3	2004	In staurosporine-treated apoptotic HaCaT cells, DP, plectin, and periplakin became cleaved coordinately with the elimination of keratins 10 and 14, while involucrin, actin, and keratin 18 displayed considerable stability.	Staurosporine	3-16	plectin	Homo sapiens	52-59
15334656-6	2004	An unspecific protein kinase C (PKC) inhibitor, staurosporine, disrupted the inhibitory action of leptin.	Staurosporine	48-61	protein kinase C delta	Homo sapiens	32-35
15334656-6	2004	An unspecific protein kinase C (PKC) inhibitor, staurosporine, disrupted the inhibitory action of leptin.	Staurosporine	48-61	leptin	Homo sapiens	98-104
15334664-6	2004	Uncoupling protein-3 expression did not cause apoptosis per se but increased the responsiveness of the cells to a mitochondrial apoptotic stimulus (i.e., addition of staurosporine in the culture medium).	Staurosporine	166-179	uncoupling protein 3	Homo sapiens	0-20
15479821-4	2004	Protein kinase C inhibitors, 1-(5-isoquinolinesulphonyl)-2, 5-dimethylpiperazine (H7) and staurosporine, inhibited the induction of p38 phosphorylation and the activation of c-Myc by TPA.	Staurosporine	90-103	mitogen-activated protein kinase 14	Homo sapiens	132-135
15479821-4	2004	Protein kinase C inhibitors, 1-(5-isoquinolinesulphonyl)-2, 5-dimethylpiperazine (H7) and staurosporine, inhibited the induction of p38 phosphorylation and the activation of c-Myc by TPA.	Staurosporine	90-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	174-179
15488733-4	2004	Staurosporine-mediated activation of the pro-apoptotic BCL-2 family member, BAX, was inhibited in the epithelial cell line infected for 32 h with the lymphogranuloma venereum (LGV/L2) but not the murine pneumonitis (MoPn) strain of C. trachomatis, but inhibition of staurosporine-mediated BAX activation disappeared after 48 h of infection with the LGV/L2 strain.	Staurosporine	0-13	B cell leukemia/lymphoma 2	Mus musculus	55-60
15488733-4	2004	Staurosporine-mediated activation of the pro-apoptotic BCL-2 family member, BAX, was inhibited in the epithelial cell line infected for 32 h with the lymphogranuloma venereum (LGV/L2) but not the murine pneumonitis (MoPn) strain of C. trachomatis, but inhibition of staurosporine-mediated BAX activation disappeared after 48 h of infection with the LGV/L2 strain.	Staurosporine	0-13	BCL2-associated X protein	Mus musculus	76-79
15488733-4	2004	Staurosporine-mediated activation of the pro-apoptotic BCL-2 family member, BAX, was inhibited in the epithelial cell line infected for 32 h with the lymphogranuloma venereum (LGV/L2) but not the murine pneumonitis (MoPn) strain of C. trachomatis, but inhibition of staurosporine-mediated BAX activation disappeared after 48 h of infection with the LGV/L2 strain.	Staurosporine	0-13	BCL2-associated X protein	Mus musculus	289-292
15488733-4	2004	Staurosporine-mediated activation of the pro-apoptotic BCL-2 family member, BAX, was inhibited in the epithelial cell line infected for 32 h with the lymphogranuloma venereum (LGV/L2) but not the murine pneumonitis (MoPn) strain of C. trachomatis, but inhibition of staurosporine-mediated BAX activation disappeared after 48 h of infection with the LGV/L2 strain.	Staurosporine	266-279	B cell leukemia/lymphoma 2	Mus musculus	55-60
15488733-4	2004	Staurosporine-mediated activation of the pro-apoptotic BCL-2 family member, BAX, was inhibited in the epithelial cell line infected for 32 h with the lymphogranuloma venereum (LGV/L2) but not the murine pneumonitis (MoPn) strain of C. trachomatis, but inhibition of staurosporine-mediated BAX activation disappeared after 48 h of infection with the LGV/L2 strain.	Staurosporine	266-279	BCL2-associated X protein	Mus musculus	76-79
15488733-6	2004	These results suggest that the ability to inhibit staurosporine-mediated BAX activation or to activate BAX due to the infection itself may vary as a function of the chlamydial strain.	Staurosporine	50-63	BCL2-associated X protein	Mus musculus	73-76
15258766-6	2004	U-73122, a selective phospholipase C (PLC) inhibitor and staurosporine and GF 109203X, which block protein kinase C (PKC), reduced ET-1-activated NSC currents by 54.2+/-5.1%, 60.3+/-5.5% and 48.5+/-2.9%, respectively.	Staurosporine	57-70	endothelin-1	Oryctolagus cuniculus	131-135
15474163-4	2004	mGluRI agonists enhanced mGluRI-Homer-PIKE-L complex formation, leading to activation of PI 3-kinase and inhibition of staurosporine-induced neuronal apoptosis.	Staurosporine	119-132	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	Homo sapiens	38-42
15504914-5	2004	T567D ezrin also induces construction of the CD44-associated polar cap, which covers the posterior cytoplasm in staurosporine-treated, uropod-disrupted EL4.G8 cells or in naturally unpolarized X63.653 myeloma cells in an actin cytoskeleton-dependent manner.	Staurosporine	112-125	CD44 antigen	Mus musculus	45-49
15504914-5	2004	T567D ezrin also induces construction of the CD44-associated polar cap, which covers the posterior cytoplasm in staurosporine-treated, uropod-disrupted EL4.G8 cells or in naturally unpolarized X63.653 myeloma cells in an actin cytoskeleton-dependent manner.	Staurosporine	112-125	epilepsy 4	Mus musculus	152-155
15369775-6	2004	Biological activity was tested as the ability to protect NIT-1 insulinoma cell line from death induced by staurosporine or serum deprivation.	Staurosporine	106-119	nitrilase 1	Mus musculus	57-62
15492260-5	2004	Treatment with cisplatin, camptothecin, etoposide, betulinic acid, celecoxib, 1400W, and staurosporine promoted enzymatic activity not only of caspases -2, -8, and -3 but also of caspase-9 in both APAF-1(+) and APAF-1(-) tumor cells.	Staurosporine	89-102	caspase 2	Homo sapiens	143-166
15492260-5	2004	Treatment with cisplatin, camptothecin, etoposide, betulinic acid, celecoxib, 1400W, and staurosporine promoted enzymatic activity not only of caspases -2, -8, and -3 but also of caspase-9 in both APAF-1(+) and APAF-1(-) tumor cells.	Staurosporine	89-102	caspase 9	Homo sapiens	179-188
15492260-5	2004	Treatment with cisplatin, camptothecin, etoposide, betulinic acid, celecoxib, 1400W, and staurosporine promoted enzymatic activity not only of caspases -2, -8, and -3 but also of caspase-9 in both APAF-1(+) and APAF-1(-) tumor cells.	Staurosporine	89-102	apoptotic peptidase activating factor 1	Homo sapiens	197-203
15492260-5	2004	Treatment with cisplatin, camptothecin, etoposide, betulinic acid, celecoxib, 1400W, and staurosporine promoted enzymatic activity not only of caspases -2, -8, and -3 but also of caspase-9 in both APAF-1(+) and APAF-1(-) tumor cells.	Staurosporine	89-102	apoptotic peptidase activating factor 1	Homo sapiens	211-217
15292186-0	2004	The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.	Staurosporine	76-89	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	39-45
15292186-3	2004	We crystallized and determined the three-dimensional structure of the catalytic subunit of ZAP-70 as a complex with staurosporine to 2.3 A resolution, utilizing an active kinase domain containing residues 327-606 identified by systematic N- and C-terminal truncations.	Staurosporine	116-129	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	91-97
15469822-5	2004	Conversely, the sensitivity to staurosporine-induced apoptosis, previously shown to be directly triggered by Drp-1-dependent recruitment of proapoptotic proteins to mitochondria, was enhanced.	Staurosporine	31-44	dynamin 1 like	Homo sapiens	109-114
15233627-10	2004	However, cyclophilin-D overexpression had opposite effects on apoptosis and necrosis; whereas NO-induced necrosis was promoted, NO- and staurosporine-induced apoptosis were inhibited.	Staurosporine	136-149	peptidylprolyl isomerase D	Homo sapiens	9-22
15167901-2	2004	High expression of CAD, but not DNase gamma, is detected in proliferating N1E-115 neuroblastoma cells, and apoptotic DNA fragmentation induced by staurosporine under proliferating conditions is abolished by the expression of a caspase-resistant form of ICAD.	Staurosporine	146-159	DNA fragmentation factor, alpha subunit	Mus musculus	253-257
15243584-4	2004	Further, we show that stem cell factor (SCF), a physiologic melanocyte growth factor that activates both the phosphatidyl-inositol-3 kinase (PI3K) and the extracellular regulated kinase (ERK) pathways, strongly protects melanocytes from TRAIL and staurosporine killing.	Staurosporine	247-260	KIT ligand	Homo sapiens	22-38
15243584-4	2004	Further, we show that stem cell factor (SCF), a physiologic melanocyte growth factor that activates both the phosphatidyl-inositol-3 kinase (PI3K) and the extracellular regulated kinase (ERK) pathways, strongly protects melanocytes from TRAIL and staurosporine killing.	Staurosporine	247-260	KIT ligand	Homo sapiens	40-43
15243584-4	2004	Further, we show that stem cell factor (SCF), a physiologic melanocyte growth factor that activates both the phosphatidyl-inositol-3 kinase (PI3K) and the extracellular regulated kinase (ERK) pathways, strongly protects melanocytes from TRAIL and staurosporine killing.	Staurosporine	247-260	mitogen-activated protein kinase 1	Homo sapiens	155-185
15243584-4	2004	Further, we show that stem cell factor (SCF), a physiologic melanocyte growth factor that activates both the phosphatidyl-inositol-3 kinase (PI3K) and the extracellular regulated kinase (ERK) pathways, strongly protects melanocytes from TRAIL and staurosporine killing.	Staurosporine	247-260	mitogen-activated protein kinase 1	Homo sapiens	187-190
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Staurosporine	36-49	ATM serine/threonine kinase	Homo sapiens	83-86
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Staurosporine	36-49	choline kinase alpha	Homo sapiens	91-94
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Staurosporine	36-49	cytochrome c, somatic	Homo sapiens	273-285
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Staurosporine	36-49	diablo IAP-binding mitochondrial protein	Homo sapiens	290-294
15466201-3	2004	The methylxanthine caffeine and the staurosporine analog UCN-01, which can inhibit ATM and Chk kinases, efficiently abrogated the IR-induced G(2)-M arrest and induced mitochondrial activation as judged by the loss of the mitochondrial membrane potential and the release of cytochrome c and Smac/Diablo.	Staurosporine	36-49	diablo IAP-binding mitochondrial protein	Homo sapiens	295-301
19003264-5	2004	The use of chemical apoptosis inhibitors was utilised to investigate key components of hepatic apoptosis where caspases, predominantly caspase 8, were implicated in staurosporine (STS)-induced HepZ apoptosis.	Staurosporine	165-178	caspase 8	Homo sapiens	111-119
19003264-5	2004	The use of chemical apoptosis inhibitors was utilised to investigate key components of hepatic apoptosis where caspases, predominantly caspase 8, were implicated in staurosporine (STS)-induced HepZ apoptosis.	Staurosporine	165-178	caspase 8	Homo sapiens	135-144
19003264-5	2004	The use of chemical apoptosis inhibitors was utilised to investigate key components of hepatic apoptosis where caspases, predominantly caspase 8, were implicated in staurosporine (STS)-induced HepZ apoptosis.	Staurosporine	180-183	caspase 8	Homo sapiens	111-119
19003264-5	2004	The use of chemical apoptosis inhibitors was utilised to investigate key components of hepatic apoptosis where caspases, predominantly caspase 8, were implicated in staurosporine (STS)-induced HepZ apoptosis.	Staurosporine	180-183	caspase 8	Homo sapiens	135-144
15504352-5	2004	Concentration- and time-dependent experiments showed that the increase in staurosporine-induced cell death was more pronounced and accelerated in cells containing expanded ataxin-3 via MTS assays.	Staurosporine	74-87	ataxin 3	Homo sapiens	172-180
15210690-5	2004	Treatment of cells with staurosporine or PD98059 blocks both Bcl2 and c-Myc phosphorylation and results in suppression of NNK-induced proliferation.	Staurosporine	24-37	BCL2 apoptosis regulator	Homo sapiens	61-65
15625319-5	2004	When quantified with [(3)H]acetic anhydride acetylation, followed by HPLC separation, the amounts of Sph-1-P and Sph decreased and increased, respectively, upon stimulation with thrombin or TPA, and these changes were attenuated by staurosporine.	Staurosporine	232-245	ankyrin 1	Homo sapiens	101-106
15625319-5	2004	When quantified with [(3)H]acetic anhydride acetylation, followed by HPLC separation, the amounts of Sph-1-P and Sph decreased and increased, respectively, upon stimulation with thrombin or TPA, and these changes were attenuated by staurosporine.	Staurosporine	232-245	coagulation factor II, thrombin	Homo sapiens	178-186
15625319-7	2004	Furthermore, when TPA-induced Sph-1-P release was blocked by staurosporine after the stimulation, the extracellular [(3)H]Sph-1-P radioactivity decreased, suggesting that the Sph-1-P released may undergo dephosphorylation extracellularly.	Staurosporine	61-74	ankyrin 1	Homo sapiens	30-35
15625319-7	2004	Furthermore, when TPA-induced Sph-1-P release was blocked by staurosporine after the stimulation, the extracellular [(3)H]Sph-1-P radioactivity decreased, suggesting that the Sph-1-P released may undergo dephosphorylation extracellularly.	Staurosporine	61-74	ankyrin 1	Homo sapiens	122-127
15625319-7	2004	Furthermore, when TPA-induced Sph-1-P release was blocked by staurosporine after the stimulation, the extracellular [(3)H]Sph-1-P radioactivity decreased, suggesting that the Sph-1-P released may undergo dephosphorylation extracellularly.	Staurosporine	61-74	ankyrin 1	Homo sapiens	122-127
15466234-8	2004	A range of protein kinase inhibitors was tested as potential modulators of NtOSAK, but only staurosporine, a rather nonspecific protein kinase inhibitor, was found to abolish the enzyme activity.	Staurosporine	92-105	serine/threonine-protein kinase SRK2A	Nicotiana tabacum	75-81
15210690-5	2004	Treatment of cells with staurosporine or PD98059 blocks both Bcl2 and c-Myc phosphorylation and results in suppression of NNK-induced proliferation.	Staurosporine	24-37	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	70-75
15339383-0	2004	Involvement of cyclin dependent kinase 5 and its activator p35 in staurosporine-induced apoptosis of cortical neurons.	Staurosporine	66-79	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	59-62
15339383-0	2004	Involvement of cyclin dependent kinase 5 and its activator p35 in staurosporine-induced apoptosis of cortical neurons.	Staurosporine	66-79	cyclin dependent kinase 5	Homo sapiens	15-40
15339383-1	2004	AIM: To investigate whether cyclin-dependent kinase 5 and its regulatory protein p35 was involved in staurosporine-induced apoptosis of cortical neuronal cultures.	Staurosporine	101-114	cyclin dependent kinase 5	Homo sapiens	28-53
15339383-1	2004	AIM: To investigate whether cyclin-dependent kinase 5 and its regulatory protein p35 was involved in staurosporine-induced apoptosis of cortical neuronal cultures.	Staurosporine	101-114	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	81-84
15339383-5	2004	The protein levels of Cdk4, p53, Cdk5, and its regulatory protein p35 following staurosporine treatment were measured by Western blotting.	Staurosporine	80-93	cyclin dependent kinase 4	Homo sapiens	22-26
15339383-5	2004	The protein levels of Cdk4, p53, Cdk5, and its regulatory protein p35 following staurosporine treatment were measured by Western blotting.	Staurosporine	80-93	cyclin dependent kinase 5	Homo sapiens	33-37
15339383-5	2004	The protein levels of Cdk4, p53, Cdk5, and its regulatory protein p35 following staurosporine treatment were measured by Western blotting.	Staurosporine	80-93	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	66-69
15339383-8	2004	The Cdk5 protein level increased markedly at 3 h and continued to 24 h. The p35 level increased at 3 h after being exposed to staurosporine, and decreased at 12 h. The cleavage of p35 to p25 was also detected at 12 h and increased at 24 h. There was no increase in Cdk5 kinase activity despite the increased cleavage of p35.	Staurosporine	126-139	cyclin dependent kinase 5	Homo sapiens	4-8
15339383-8	2004	The Cdk5 protein level increased markedly at 3 h and continued to 24 h. The p35 level increased at 3 h after being exposed to staurosporine, and decreased at 12 h. The cleavage of p35 to p25 was also detected at 12 h and increased at 24 h. There was no increase in Cdk5 kinase activity despite the increased cleavage of p35.	Staurosporine	126-139	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	76-79
15339383-8	2004	The Cdk5 protein level increased markedly at 3 h and continued to 24 h. The p35 level increased at 3 h after being exposed to staurosporine, and decreased at 12 h. The cleavage of p35 to p25 was also detected at 12 h and increased at 24 h. There was no increase in Cdk5 kinase activity despite the increased cleavage of p35.	Staurosporine	126-139	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	180-183
15339383-8	2004	The Cdk5 protein level increased markedly at 3 h and continued to 24 h. The p35 level increased at 3 h after being exposed to staurosporine, and decreased at 12 h. The cleavage of p35 to p25 was also detected at 12 h and increased at 24 h. There was no increase in Cdk5 kinase activity despite the increased cleavage of p35.	Staurosporine	126-139	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	180-183
15339383-9	2004	The protein level of Cdk4 protein increased at 3 h and then decreased gradually from 6 h, but it was still higher than that in the vehicle cultures at 12 h. The p53 level decreased obviously at 3 h after staurosporine treatment and then seemed to increase at 12 h, but remained lower than that of vehicle cultures.	Staurosporine	204-217	cyclin dependent kinase 4	Homo sapiens	21-25
15339383-9	2004	The protein level of Cdk4 protein increased at 3 h and then decreased gradually from 6 h, but it was still higher than that in the vehicle cultures at 12 h. The p53 level decreased obviously at 3 h after staurosporine treatment and then seemed to increase at 12 h, but remained lower than that of vehicle cultures.	Staurosporine	204-217	tumor protein p53	Homo sapiens	161-164
15339383-10	2004	CONCLUSION: Staurosporine-induced increase in Cdk5 protein levels and the cleavage of p35 to p25 may contribute to neuronal apoptosis.	Staurosporine	12-25	cyclin dependent kinase 5	Homo sapiens	46-50
15339383-10	2004	CONCLUSION: Staurosporine-induced increase in Cdk5 protein levels and the cleavage of p35 to p25 may contribute to neuronal apoptosis.	Staurosporine	12-25	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	86-89
15339383-10	2004	CONCLUSION: Staurosporine-induced increase in Cdk5 protein levels and the cleavage of p35 to p25 may contribute to neuronal apoptosis.	Staurosporine	12-25	cyclin dependent kinase 5 regulatory subunit 1	Homo sapiens	93-96
15175341-10	2004	In fact, reduction of endogenous hDAP3 protein by RNA interference partially attenuated staurosporine-induced mitochondrial fission.	Staurosporine	88-101	death associated protein 3	Homo sapiens	33-38
15140747-5	2004	In KCNA5-transfected COS-7 cells, staurosporine (ST)-mediated increases in caspase-3 activity and the percentage of cells undergoing apoptosis were both enhanced, whereas basal apoptosis (without ST stimulation) was unchanged compared with cells transfected with an empty vector.	Staurosporine	34-47	potassium voltage-gated channel subfamily A member 5	Homo sapiens	3-8
15140747-5	2004	In KCNA5-transfected COS-7 cells, staurosporine (ST)-mediated increases in caspase-3 activity and the percentage of cells undergoing apoptosis were both enhanced, whereas basal apoptosis (without ST stimulation) was unchanged compared with cells transfected with an empty vector.	Staurosporine	34-47	caspase 3	Homo sapiens	75-84
15140747-5	2004	In KCNA5-transfected COS-7 cells, staurosporine (ST)-mediated increases in caspase-3 activity and the percentage of cells undergoing apoptosis were both enhanced, whereas basal apoptosis (without ST stimulation) was unchanged compared with cells transfected with an empty vector.	Staurosporine	49-51	potassium voltage-gated channel subfamily A member 5	Homo sapiens	3-8
15140747-5	2004	In KCNA5-transfected COS-7 cells, staurosporine (ST)-mediated increases in caspase-3 activity and the percentage of cells undergoing apoptosis were both enhanced, whereas basal apoptosis (without ST stimulation) was unchanged compared with cells transfected with an empty vector.	Staurosporine	49-51	caspase 3	Homo sapiens	75-84
15336502-2	2004	Regarding the antiapoptotic mechanisms, we have previously demonstrated that under staurosporine treatment, HalphaA- and HalphaB-crystallins can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family, to sequester their translocation into mitochondria, and thus prevent the staurosporine-induced apoptosis.	Staurosporine	83-96	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
15336502-2	2004	Regarding the antiapoptotic mechanisms, we have previously demonstrated that under staurosporine treatment, HalphaA- and HalphaB-crystallins can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family, to sequester their translocation into mitochondria, and thus prevent the staurosporine-induced apoptosis.	Staurosporine	290-303	BCL2 associated X, apoptosis regulator	Homo sapiens	159-162
15306200-4	2004	Western blotting showed that both PKC412 (10 microM) and staurosporine (100 nM) cleaved pro-caspase-3 to active forms.	Staurosporine	57-70	caspase 3	Homo sapiens	92-101
15306200-5	2004	An in vitro caspase assay also showed that PKC412 and staurosporine elevated caspase-3 activities.	Staurosporine	54-67	caspase 3	Homo sapiens	77-86
15306200-6	2004	Carbobenzoxy-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK), a caspase inhibitor with a broad spectrum, inhibited caspase-3 activities stimulated by PKC412 and staurosporine; however, only PKC412-induced apoptosis, but not staurosporine-induced apoptosis, was prevented by Z-VAD-FMK.	Staurosporine	157-170	caspase 3	Homo sapiens	111-120
15306200-6	2004	Carbobenzoxy-Val-Ala-Asp-fluoromethyl ketone (Z-VAD-FMK), a caspase inhibitor with a broad spectrum, inhibited caspase-3 activities stimulated by PKC412 and staurosporine; however, only PKC412-induced apoptosis, but not staurosporine-induced apoptosis, was prevented by Z-VAD-FMK.	Staurosporine	220-233	caspase 3	Homo sapiens	111-120
15144237-7	2004	However, both GPCR and PMA potentiation were blocked by the kinase inhibitor staurosporine.	Staurosporine	77-90	vomeronasal 1 receptor 17 pseudogene	Homo sapiens	14-18
15144237-9	2004	This demonstrates that P2X1 regulation does not result directly from phosphorylation of the channel, but more likely by a staurosporine-sensitive phosphorylation of an accessory protein in the P2X1 receptor complex and suggests that in vivo fine-tuning of P2X1 receptors by GPCRs may contribute to cardiovascular control and haemostasis.	Staurosporine	122-135	purinergic receptor P2X 1	Homo sapiens	23-27
15144237-9	2004	This demonstrates that P2X1 regulation does not result directly from phosphorylation of the channel, but more likely by a staurosporine-sensitive phosphorylation of an accessory protein in the P2X1 receptor complex and suggests that in vivo fine-tuning of P2X1 receptors by GPCRs may contribute to cardiovascular control and haemostasis.	Staurosporine	122-135	purinergic receptor P2X 1	Homo sapiens	193-206
15144237-9	2004	This demonstrates that P2X1 regulation does not result directly from phosphorylation of the channel, but more likely by a staurosporine-sensitive phosphorylation of an accessory protein in the P2X1 receptor complex and suggests that in vivo fine-tuning of P2X1 receptors by GPCRs may contribute to cardiovascular control and haemostasis.	Staurosporine	122-135	purinergic receptor P2X 1	Homo sapiens	193-197
15450082-8	2004	The actions of BMP-7 on both AMPA and kainate receptors were blocked by the nonselective kinase inhibitor, staurosporine.	Staurosporine	107-120	bone morphogenetic protein 7	Homo sapiens	15-20
15314085-5	2004	The inhibition of PKC by staurosporin, as well as its downregulation, decreased the ability of bFGF+dbcAMP to generate tyrosine hydroxylase-positive cells.	Staurosporine	25-37	fibroblast growth factor 2	Rattus norvegicus	95-99
15272311-6	2004	Indeed, overexpression of alpha-SNAP markedly delayed staurosporine-induced apoptosis.	Staurosporine	54-67	NSF attachment protein alpha	Homo sapiens	26-36
15184368-9	2004	Knockdown of bcl-2 expression by siRNA in cardiac fibroblasts increased their apoptotic response to staurosporine, serum, and glucose deprivation and to simulated ischemia.	Staurosporine	100-113	BCL2 apoptosis regulator	Homo sapiens	13-18
15177934-8	2004	The effects of NT on EGFR/ERK/Akt activation and DNA synthesis were attenuated by PLC-inhibitor (U73122), PKC-inhibitors (bisindolylmaleimide, staurosporine, rottlerin), MEK inhibitor (U0126) and PI3 kinase inhibitors (wortmannin, LY 294002).	Staurosporine	143-156	mitogen-activated protein kinase 1	Homo sapiens	26-29
15262504-4	2004	The presence of gene EP153R resulted in a reduction of the transactivating activity of the cellular protein p53 in Vero cell cultures in which apoptosis was induced by virus infection or staurosporine treatment.	Staurosporine	187-200	lectin-like protein	African swine fever virus	21-27
15072960-3	2004	The PKC blocker staurosporine (10 microM) eliminated ANG II (10 nM)-induced vasoconstriction, inhibited pericyte cytoplasmic Ca(2+) concentration ([Ca(2+)](cyt)) elevation, and blocked Mn(2+) influx into the cytoplasm.	Staurosporine	16-29	protein kinase C, gamma	Rattus norvegicus	4-7
15072960-3	2004	The PKC blocker staurosporine (10 microM) eliminated ANG II (10 nM)-induced vasoconstriction, inhibited pericyte cytoplasmic Ca(2+) concentration ([Ca(2+)](cyt)) elevation, and blocked Mn(2+) influx into the cytoplasm.	Staurosporine	16-29	angiotensinogen	Rattus norvegicus	53-59
15287883-9	2004	The increase in NCX activity and NCX protein by IFN-gamma for 24 h was blocked by staurosporine, GF109203X, herbimycin A and the extracellular signal-regulated kinase inhibitor, PD98059.	Staurosporine	82-95	solute carrier family 8 member A1	Rattus norvegicus	16-19
15159409-5	2004	Fas-induced, caspase-8-independent exposure of the N terminus of Bak is blocked by staurosporine, a pan protein kinase inhibitor.	Staurosporine	83-96	caspase 8	Homo sapiens	13-22
15159409-5	2004	Fas-induced, caspase-8-independent exposure of the N terminus of Bak is blocked by staurosporine, a pan protein kinase inhibitor.	Staurosporine	83-96	BCL2 antagonist/killer 1	Homo sapiens	65-68
15287883-9	2004	The increase in NCX activity and NCX protein by IFN-gamma for 24 h was blocked by staurosporine, GF109203X, herbimycin A and the extracellular signal-regulated kinase inhibitor, PD98059.	Staurosporine	82-95	solute carrier family 8 member A1	Rattus norvegicus	33-36
15287883-9	2004	The increase in NCX activity and NCX protein by IFN-gamma for 24 h was blocked by staurosporine, GF109203X, herbimycin A and the extracellular signal-regulated kinase inhibitor, PD98059.	Staurosporine	82-95	interferon gamma	Rattus norvegicus	48-57
15102863-6	2004	In contrast, apoptosis induced by staurosporine does not require protein synthesis but is characterized by translocation of BAX.	Staurosporine	34-47	BCL2 associated X, apoptosis regulator	Homo sapiens	124-127
15020298-4	2004	This caveolin-1 alpha-mutated line was also resistant to H(2)O(2) and staurosporine, but not to lonidamine.	Staurosporine	70-83	caveolin 1, caveolae protein	Mus musculus	5-15
15028782-5	2004	However, ZVAD-fmk only decreased cisplatin- and staurosporine-induced annexin V staining and cell shrinkage 30 to 50%, staurosporine-induced TUNEL staining 30%, and did not affect vincristine- or A23187-induced RPTC apoptosis.	Staurosporine	48-61	annexin A5	Mus musculus	70-79
15146537-5	2004	Staurosporine, a non-specific inhibitor of serine/threonine kinases, reduced RacQ61-induced phosphorylation of MLC by about 58%, at the maximum concentration that did not kill cells.	Staurosporine	0-13	modulator of VRAC current 1	Homo sapiens	111-114
15028782-8	2004	Cisplatin and staurosporine also induced annexin V staining in the human epithelial cancer cell lines Caki-1 (kidney carcinoma), A549 (lung carcinoma), A172 (glioblastoma), and murine lymphocytic leukemia L1210 cells.	Staurosporine	14-27	annexin A5	Homo sapiens	41-50
15194160-5	2004	Pre-treatment with staurosporin, a potent inhibitor of protein kinases (PKs) and with genistein, a specific tyrosine kinase inhibitor decreased the number of internalised bacteria about seven-fold and two-fold, respectively, indicating the involvement of PKs including tyrosine kinases in Pla-mediated internalisation.	Staurosporine	19-31	plasminogen activator protease precursor	Yersinia pestis	289-292
15142951-7	2004	Collagen or CRP-stimulated 12-H(P)ETE generation was inhibited by staurosporine, PP2, wortmannin, BAPTA/AM, EGTA, and L-655238, implicating src-tyrosine kinases, PI3-kinase, Ca2+ mobilization, and p12-LOX translocation.	Staurosporine	66-79	C-reactive protein	Homo sapiens	12-15
15096511-5	2004	Ectopic NHE1, but not NHE3, expression rescued NHE1-null cells from apoptosis induced by staurosporine or N-ethylmaleimide-stimulated KCl efflux.	Staurosporine	89-102	solute carrier family 9 member A1	Homo sapiens	47-51
15028782-3	2004	Cisplatin, staurosporine, vincristine, and A23187 induced RPTC apoptosis after 24 h as indicated by 2- to 2.5-fold increases in annexin V and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL) staining, and 2- to 10-fold increases in cell shrinkage.	Staurosporine	11-24	annexin A5	Mus musculus	128-137
14748742-0	2004	Bcl2-low-expressing MCF7 cells undergo necrosis rather than apoptosis upon staurosporine treatment.	Staurosporine	75-88	BCL2 apoptosis regulator	Homo sapiens	0-4
14748742-3	2004	Rz-bcl2-expressing cells were more sensitive to staurosporine than control cells.	Staurosporine	48-61	BCL2 apoptosis regulator	Homo sapiens	3-7
14752512-0	2004	Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis.	Staurosporine	102-115	BCL2 associated X, apoptosis regulator	Homo sapiens	45-48
14752512-0	2004	Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis.	Staurosporine	102-115	BCL2 like 1	Homo sapiens	53-58
14752512-7	2004	Through the interaction, alpha-crystallins prevent the translocation of Bax and Bcl-X(S) from cytosol into mitochondria during staurosporine-induced apoptosis.	Staurosporine	127-140	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
14752512-7	2004	Through the interaction, alpha-crystallins prevent the translocation of Bax and Bcl-X(S) from cytosol into mitochondria during staurosporine-induced apoptosis.	Staurosporine	127-140	BCL2 like 1	Homo sapiens	80-85
15093730-5	2004	The activation of the caspase-3 was also inhibited by NMDA, and the neurons were more resistant towards death caused by high concentrations of glutamate and staurosporine.	Staurosporine	157-170	caspase 3	Homo sapiens	22-31
14998548-4	2004	Actually, it has been shown that the expression of CEA can be up-regulated by pharmacological agents including, antineoplastic drugs (i.e. 5-fluorouracil), cytokines (i.e. interferons or interleukin-6), differentiating agents (i.e. sodium butyrate) and protein kinase inhibitors (i.e. staurosporine).	Staurosporine	285-298	CEA cell adhesion molecule 3	Homo sapiens	51-54
15081634-7	2004	Staurosporine induced PS efflux was not affected by vanadate (69.6 [5.5] Lum x10(3)), but was inhibited 87.8 per cent by Z-VAD-fmk; from 71.5 [6.2] to 8.7 [3.6] Lum (x10(3)) (P&lt;0.001).	Staurosporine	0-13	lumican	Homo sapiens	161-164
15287883-6	2004	The transient increase in NCX activity by IFN-gamma for 1 h was blocked by the protein kinase C (PKC) inhibitors, staurosporine and GF109203X, and the tyrosine kinase inhibitor, herbimycin A.	Staurosporine	114-127	solute carrier family 8 member A1	Rattus norvegicus	26-29
15287883-6	2004	The transient increase in NCX activity by IFN-gamma for 1 h was blocked by the protein kinase C (PKC) inhibitors, staurosporine and GF109203X, and the tyrosine kinase inhibitor, herbimycin A.	Staurosporine	114-127	interferon gamma	Rattus norvegicus	42-51
15096511-5	2004	Ectopic NHE1, but not NHE3, expression rescued NHE1-null cells from apoptosis induced by staurosporine or N-ethylmaleimide-stimulated KCl efflux.	Staurosporine	89-102	solute carrier family 9 member A1	Homo sapiens	8-12
15161627-9	2004	However, staurosporine induced cleavage of the probe in caspase 8-deficient cells by a mechanism that was inhibited by overexpression of bcl-x.	Staurosporine	9-22	caspase 8	Homo sapiens	56-65
15161627-9	2004	However, staurosporine induced cleavage of the probe in caspase 8-deficient cells by a mechanism that was inhibited by overexpression of bcl-x.	Staurosporine	9-22	BCL2 like 1	Homo sapiens	137-142
14963413-4	2004	Prolonged incubation (&gt;2 h) with staurosporine caused a decrease in intracellular pH, which, however, was not required for the progression of the apoptotic process, because inhibitors of proton extrusion pathways, which lowered cytoplasmic pH, failed to inhibit both caspase-3 activation and DNA laddering.	Staurosporine	36-49	caspase 3	Homo sapiens	270-279
15181072-8	2004	IL-4 very weakly stimulated thyroid cancer cell proliferation, but it was very effective in protecting thyroid cancer cells from apoptosis induced by staurosporin.	Staurosporine	150-162	interleukin 4	Homo sapiens	0-4
15189346-5	2004	U-373 cell viability showed a three-fold decrease (from 20 to 60% cell death) following treatment with staurosporine, C2-ceramide or etoposide, when either alpha2,6ST and GnT-V genes were stably overexpressed.	Staurosporine	103-116	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	171-176
15189356-1	2004	Activation of metabotropic glutamate receptor 5 (mGluR5) has been shown to reduce caspase-dependent apoptosis in primary neuronal cultures induced by staurosporine and etoposide.	Staurosporine	150-163	glutamate metabotropic receptor 5	Rattus norvegicus	14-47
15189356-1	2004	Activation of metabotropic glutamate receptor 5 (mGluR5) has been shown to reduce caspase-dependent apoptosis in primary neuronal cultures induced by staurosporine and etoposide.	Staurosporine	150-163	glutamate receptor, ionotropic, kainate 1	Mus musculus	49-55
15044591-8	2004	However, it is not inhibited by the kinase inhibitor, staurosporine, which markedly inhibits GHR tyrosine phosphorylation.	Staurosporine	54-67	growth hormone receptor	Mus musculus	93-96
15209419-3	2004	We found that the PTP inhibitor orthovanadate (1 microM) enhanced TrkA phosphorylation and protected neurons against staurosporine (STS)-induced apoptosis in a time-and concentration-dependent manner.	Staurosporine	117-130	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	18-21
15209419-3	2004	We found that the PTP inhibitor orthovanadate (1 microM) enhanced TrkA phosphorylation and protected neurons against staurosporine (STS)-induced apoptosis in a time-and concentration-dependent manner.	Staurosporine	132-135	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	18-21
15147901-5	2004	During the characterization of the staurosporine-induced apoptotic process in human neuroblastoma cell lines, we have found three novel splice variants of CAD.	Staurosporine	35-48	DNA fragmentation factor subunit beta	Homo sapiens	155-158
15129168-3	2004	The over-expression of CREB but not A-CREB was found to protect primary hippocampal neurons from staurosporine-induced apoptosis, glutamate induced excitotoxicity and exposure to an in vitro ischaemic stress.	Staurosporine	97-110	cAMP responsive element binding protein 1	Homo sapiens	23-27
15150589-3	2004	Proteasome expression induced by PIF was attenuated by 4alpha-phorbol 12-myristate 13-acetate (100 nM) and by the PKC inhibitors Ro31-8220 (10 microM), staurosporine (300 nM), calphostin C (300 nM) and Go 6976 (200 microM).	Staurosporine	152-165	Pif	Mus musculus	33-36
15150589-3	2004	Proteasome expression induced by PIF was attenuated by 4alpha-phorbol 12-myristate 13-acetate (100 nM) and by the PKC inhibitors Ro31-8220 (10 microM), staurosporine (300 nM), calphostin C (300 nM) and Go 6976 (200 microM).	Staurosporine	152-165	protein kinase C, alpha	Mus musculus	114-117
15086447-7	2004	The broad specificity inhibitor staurosporine inhibited the response to ET-1, but inhibitors of Rho-A kinase and phosphatidylinositol 3-kinase had no effect.	Staurosporine	32-45	endothelin 1	Rattus norvegicus	72-76
15111329-4	2004	The VEGF-induced mRNA increase of Ets-1 was suppressed by a tyrosine kinase inhibitor (genistein), by inhibitors of MEK (mitogen-activated protein and extracellular signal-regulated kinase kinase) (PD98059 and UO126), and by inhibitors of protein kinase C (GF109203X, staurosporine, and Go6976).	Staurosporine	268-281	vascular endothelial growth factor A	Mus musculus	4-8
15111329-4	2004	The VEGF-induced mRNA increase of Ets-1 was suppressed by a tyrosine kinase inhibitor (genistein), by inhibitors of MEK (mitogen-activated protein and extracellular signal-regulated kinase kinase) (PD98059 and UO126), and by inhibitors of protein kinase C (GF109203X, staurosporine, and Go6976).	Staurosporine	268-281	E26 avian leukemia oncogene 1, 5' domain	Mus musculus	34-39
15258465-0	2004	Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells.	Staurosporine	118-131	tumor protein p53	Homo sapiens	31-34
15258465-0	2004	Mitochondrial translocation of p53 and mitochondrial membrane potential (Delta Psi m) dissipation are early events in staurosporine-induced apoptosis of wild type and mutated p53 epithelial cells.	Staurosporine	118-131	tumor protein p53	Homo sapiens	175-178
14695913-9	2004	Aurora-A was not found in the spindle region when colchicine or staurosporine was used to inhibit microtubule organization, while it accumulated as several dots in the cytoplasm after taxol treatment.	Staurosporine	64-77	aurora kinase A	Mus musculus	0-8
15096609-6	2004	Thus, it is concluded that an apoptosis-triggering anion conductance is carried by the volume-sensitive outwardly rectifying Cl(-) channel and that the channel activation on apoptotic stimulation with staurosporine, but not with Fas ligand or TNF-alpha, is mediated by ROS.	Staurosporine	201-214	tumor necrosis factor	Homo sapiens	243-252
15126291-6	2004	Moreover, we demonstrated activation of caspase 3 by Western blot and enhanced release of cytochrome c after 100 nM staurosporine treatment or 20 J/m(2) UV irradiation of the cybrids harboring high levels of the three mtDNA mutations.	Staurosporine	116-129	cytochrome c, somatic	Homo sapiens	90-102
15029247-2	2004	Recently, we found that ARTS is also important for cell killing by other pro-apoptotic factors, such as arabinoside, etoposide, staurosporine and Fas.	Staurosporine	128-141	septin 4	Homo sapiens	24-28
15041741-8	2004	Further, exogenous galanin or the previously described high-affinity GALR2 agonist, both reduced cell death when coadministered with glutamate or staurosporine in WT cultures.	Staurosporine	146-159	galanin receptor 2	Homo sapiens	69-74
14644748-8	2004	The effects of ANG II on AA release and alpha-MG uptake also were abolished by staurosporine and bisindolylmaleimide I (protein kinase C inhibitors) or PD-98059 (p44/42 MAPK inhibitor), but not SB-203580 (p38 MAPK inhibitor), respectively.	Staurosporine	79-92	angiogenin	Oryctolagus cuniculus	15-18
14644748-10	2004	ANG II-induced activation of p44/42 MAPK was blocked by staurosporine.	Staurosporine	56-69	angiogenin	Oryctolagus cuniculus	0-3
15126292-8	2004	SK-Hep1 rho(0) cells were resistant to other death effectors such as staurosporine.	Staurosporine	69-82	DNL-type zinc finger	Homo sapiens	3-7
15006899-11	2004	Moreover, the protein kinase inhibitor staurosporine significantly inhibited AEA- and CAP-evoked CGRP release.	Staurosporine	39-52	calcitonin-related polypeptide alpha	Rattus norvegicus	97-101
15053922-9	2004	Inhibition of protein kinases by means of staurosporine suppressed the stress-induced expression of Cyr61 and CTGF.	Staurosporine	42-55	cellular communication network factor 1	Homo sapiens	100-105
15053922-9	2004	Inhibition of protein kinases by means of staurosporine suppressed the stress-induced expression of Cyr61 and CTGF.	Staurosporine	42-55	cellular communication network factor 2	Homo sapiens	110-114
15010857-0	2004	Staurosporine-induced apoptosis in Chang liver cells is associated with down-regulation of Bcl-2 and Bcl-XL.	Staurosporine	0-13	BCL2 apoptosis regulator	Homo sapiens	91-96
14666386-5	2004	After 4.5 h of staurosporine treatment, a tenfold increase in (99m)Tc-MIBI uptake was observed in treated as compared with untreated Bcl-2 overexpressing cells.	Staurosporine	15-28	BCL2 apoptosis regulator	Homo sapiens	133-138
15010857-0	2004	Staurosporine-induced apoptosis in Chang liver cells is associated with down-regulation of Bcl-2 and Bcl-XL.	Staurosporine	0-13	BCL2 like 1	Homo sapiens	101-107
15010857-6	2004	Western blotting analysis showed that in Chang liver cells staurosporine induced a marked decrease in the levels of the antiapoptotic factors Bcl-2 (-75%) and Bcl-XL (-50%).	Staurosporine	59-72	BCL2 apoptosis regulator	Homo sapiens	142-147
15010857-6	2004	Western blotting analysis showed that in Chang liver cells staurosporine induced a marked decrease in the levels of the antiapoptotic factors Bcl-2 (-75%) and Bcl-XL (-50%).	Staurosporine	59-72	BCL2 like 1	Homo sapiens	159-165
15010857-7	2004	Staurosporine also caused loss of mitochondrial transmembrane potential, release of cytochrome c from mitochondria and activation of caspase-3.	Staurosporine	0-13	cytochrome c, somatic	Homo sapiens	84-96
15010857-7	2004	Staurosporine also caused loss of mitochondrial transmembrane potential, release of cytochrome c from mitochondria and activation of caspase-3.	Staurosporine	0-13	caspase 3	Homo sapiens	133-142
15010857-11	2004	We conclude that staurosporine induced apoptosis in Chang liver cells by a mitochondria-caspase-dependent pathway which was closely correlated with a decrease in Bcl-2 and Bcl-XL levels, while in HuH-6 and HepG2 hepatoma cells the drug caused only an antiproliferative effect.	Staurosporine	17-30	BCL2 apoptosis regulator	Homo sapiens	162-167
15010857-11	2004	We conclude that staurosporine induced apoptosis in Chang liver cells by a mitochondria-caspase-dependent pathway which was closely correlated with a decrease in Bcl-2 and Bcl-XL levels, while in HuH-6 and HepG2 hepatoma cells the drug caused only an antiproliferative effect.	Staurosporine	17-30	BCL2 like 1	Homo sapiens	172-178
14963000-7	2004	Furthermore, activation of protein kinase Cepsilon (PKCepsilon) was necessary for length recovery, as nonselective PKC inhibitors [staurosporine (5 micromol/L) and chelerythrine chloride (10 micromol/L)], and a replication-defective adenovirus (Adv) encoding a dominant-negative mutant of PKCepsilon prevented the restoration of sarcomere length.	Staurosporine	131-144	protein kinase C, epsilon	Rattus norvegicus	27-50
14707121-5	2004	Also, nGAP protected the cells against staurosporin-induced apoptosis through an Akt-dependent pathway.	Staurosporine	39-51	RAS protein activator like 2	Homo sapiens	6-10
14707121-5	2004	Also, nGAP protected the cells against staurosporin-induced apoptosis through an Akt-dependent pathway.	Staurosporine	39-51	AKT serine/threonine kinase 1	Homo sapiens	81-84
14966800-6	2004	After exposure to serum deprivation, 4- and 5-day spent medium, and staurosporine, cells expressing Aven provided limited protection against cell death when compared with the protection afforded by cells expressing Bcl-xL alone.	Staurosporine	68-81	apoptosis and caspase activation inhibitor	Homo sapiens	100-104
14963000-7	2004	Furthermore, activation of protein kinase Cepsilon (PKCepsilon) was necessary for length recovery, as nonselective PKC inhibitors [staurosporine (5 micromol/L) and chelerythrine chloride (10 micromol/L)], and a replication-defective adenovirus (Adv) encoding a dominant-negative mutant of PKCepsilon prevented the restoration of sarcomere length.	Staurosporine	131-144	protein kinase C, epsilon	Rattus norvegicus	52-62
14963000-7	2004	Furthermore, activation of protein kinase Cepsilon (PKCepsilon) was necessary for length recovery, as nonselective PKC inhibitors [staurosporine (5 micromol/L) and chelerythrine chloride (10 micromol/L)], and a replication-defective adenovirus (Adv) encoding a dominant-negative mutant of PKCepsilon prevented the restoration of sarcomere length.	Staurosporine	131-144	protein kinase C, epsilon	Rattus norvegicus	52-55
15009062-5	2004	However, caspase-8 was processed and functional after treatment with staurosporine (STS).	Staurosporine	69-82	caspase 8	Homo sapiens	9-18
14656220-4	2004	Fibroblast apoE mRNA and protein levels were up-regulated during staurosporine-induced apoptosis and this was correlated with increased caspase-3 activity and apoptotic morphological alterations.	Staurosporine	65-78	apolipoprotein E	Homo sapiens	11-15
15009062-5	2004	However, caspase-8 was processed and functional after treatment with staurosporine (STS).	Staurosporine	84-87	caspase 8	Homo sapiens	9-18
15120419-7	2004	RESULTS: The fraction of staurosporine-induced early apoptosis but not that of secondary necrosis in PBL was reduced by the treatment with either DHEA or DHEAS.	Staurosporine	25-38	sulfotransferase family 2A member 1	Homo sapiens	154-159
14762654-9	2004	Glucagon-like peptide-1 also stimulated INS-1 cell proliferation in a dose-dependent manner (by 1.8+/-0.5-fold at 10(-7) mol/l, p&lt;0.01), and inhibited staurosporine-induced apoptosis (by 69+/-12%, p&lt;0.05).	Staurosporine	154-167	glucagon	Rattus norvegicus	0-23
14985459-3	2004	We report that although staurosporine activated Bax and the mitochondrial caspase-dependent apoptotic pathway, it also induced apoptosis of melanoma by caspase-independent pathways.	Staurosporine	24-37	BCL2 associated X, apoptosis regulator	Homo sapiens	48-51
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Staurosporine	230-243	signal transducer and activator of transcription 1	Homo sapiens	30-80
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Staurosporine	230-243	signal transducer and activator of transcription 1	Homo sapiens	82-87
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Staurosporine	230-243	interferon gamma	Homo sapiens	100-116
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	Staurosporine	230-243	interferon gamma	Homo sapiens	118-127
14980204-6	2004	Suppression of the function of ataxia telangiectasia mutated (ATM), a proximal component of DNA damage-induced cell cycle checkpoint pathways, attenuated both apoptosis and cell cycle reentry triggered by DNA damage but did not change the fate of neurons exposed to staurosporine and colchicine.	Staurosporine	266-279	ATM serine/threonine kinase	Homo sapiens	62-65
14980205-2	2004	Here, we report that APC protects mouse cortical neurons from two divergent inducers of apoptosis, N-methyl-D-aspartate (NMDA) and staurosporine.	Staurosporine	131-144	APC, WNT signaling pathway regulator	Mus musculus	21-24
14980205-3	2004	APC blocked several steps in NMDA-induced apoptosis downstream to nitric oxide, i.e., caspase-3 activation, nuclear translocation of apoptosis-inducing factor (AIF), and induction of p53, and prevented staurosporine-induced apoptosis by blocking caspase-8 activation upstream of caspase-3 activation and AIF nuclear translocation.	Staurosporine	202-215	APC, WNT signaling pathway regulator	Mus musculus	0-3
14660621-4	2004	The mechanosensitivity of the GIRK4 current was abolished by pretreatment with PKC inhibitors (staurosporine or calphostin C).	Staurosporine	95-108	potassium inwardly rectifying channel subfamily J member 5 L homeolog	Xenopus laevis	30-35
14729058-7	2004	Staurosporine induced recruitment of filamentous actin (F-actin), cortactin, filamin, Arp2/3 complex, Rac1 GTPase and phospholipase C-gamma1 (PLC-gamma1) to lamellipodia.	Staurosporine	0-13	cortactin	Homo sapiens	66-75
14729058-7	2004	Staurosporine induced recruitment of filamentous actin (F-actin), cortactin, filamin, Arp2/3 complex, Rac1 GTPase and phospholipase C-gamma1 (PLC-gamma1) to lamellipodia.	Staurosporine	0-13	filamin C	Homo sapiens	77-84
14729058-7	2004	Staurosporine induced recruitment of filamentous actin (F-actin), cortactin, filamin, Arp2/3 complex, Rac1 GTPase and phospholipase C-gamma1 (PLC-gamma1) to lamellipodia.	Staurosporine	0-13	actin related protein 2	Homo sapiens	86-90
14729058-7	2004	Staurosporine induced recruitment of filamentous actin (F-actin), cortactin, filamin, Arp2/3 complex, Rac1 GTPase and phospholipase C-gamma1 (PLC-gamma1) to lamellipodia.	Staurosporine	0-13	Rac family small GTPase 1	Homo sapiens	102-106
14729058-7	2004	Staurosporine induced recruitment of filamentous actin (F-actin), cortactin, filamin, Arp2/3 complex, Rac1 GTPase and phospholipase C-gamma1 (PLC-gamma1) to lamellipodia.	Staurosporine	0-13	phospholipase C gamma 1	Homo sapiens	118-140
14729058-7	2004	Staurosporine induced recruitment of filamentous actin (F-actin), cortactin, filamin, Arp2/3 complex, Rac1 GTPase and phospholipase C-gamma1 (PLC-gamma1) to lamellipodia.	Staurosporine	0-13	phospholipase C gamma 1	Homo sapiens	142-152
14568554-5	2004	Annexin-V labeling increased rapidly in synaptosomes, following a 1 min incubation with staurosporine.	Staurosporine	88-101	annexin A5	Rattus norvegicus	0-9
14751780-8	2004	Interestingly, treatment with staurosporine (STS) triggered caspase-9 and -3 in cortical and striatal cells, suggesting that the molecular machinery related to caspase-dependent apoptosis was functional in both cell types even though this machinery was not involved in 3NP toxicity.	Staurosporine	30-43	caspase 9	Homo sapiens	60-76
14751780-8	2004	Interestingly, treatment with staurosporine (STS) triggered caspase-9 and -3 in cortical and striatal cells, suggesting that the molecular machinery related to caspase-dependent apoptosis was functional in both cell types even though this machinery was not involved in 3NP toxicity.	Staurosporine	30-43	caspase 9	Homo sapiens	60-67
14985459-4	2004	The caspase-dependent apoptotic pathway was activated relatively soon after exposure to staurosporine and was associated with release of cytochrome c and Smac/DIABLO from mitochondria and cleavage of poly(ADP-ribose) polymerase and inhibitor of caspase-activated DNase.	Staurosporine	88-101	cytochrome c, somatic	Homo sapiens	137-149
14985459-4	2004	The caspase-dependent apoptotic pathway was activated relatively soon after exposure to staurosporine and was associated with release of cytochrome c and Smac/DIABLO from mitochondria and cleavage of poly(ADP-ribose) polymerase and inhibitor of caspase-activated DNase.	Staurosporine	88-101	diablo IAP-binding mitochondrial protein	Homo sapiens	154-158
14985459-4	2004	The caspase-dependent apoptotic pathway was activated relatively soon after exposure to staurosporine and was associated with release of cytochrome c and Smac/DIABLO from mitochondria and cleavage of poly(ADP-ribose) polymerase and inhibitor of caspase-activated DNase.	Staurosporine	88-101	diablo IAP-binding mitochondrial protein	Homo sapiens	159-165
14729230-5	2004	The increase in caspase-3 activity after coincubation with statins and staurosporine was paralleled by an increase in the protein level of the pro-apoptotic GTPase RhoB.	Staurosporine	71-84	caspase 3	Mus musculus	16-25
15214581-7	2004	Finally, we showed that culture of oocytes in staurosporine increased the activity of caspase-8 and caspase-9.	Staurosporine	46-59	caspase 8	Mus musculus	86-95
15214581-7	2004	Finally, we showed that culture of oocytes in staurosporine increased the activity of caspase-8 and caspase-9.	Staurosporine	46-59	caspase 9	Mus musculus	100-109
15319533-6	2004	In contrast, in RA-DF and RA-SF staurosporine significantly augmented IL-16 RT/PCR signals, but forskolin induced less IL-16 transcript amounts.	Staurosporine	32-45	interleukin 16	Homo sapiens	70-75
12970677-6	2004	Upon activation, c-Myc-deficient B lymphocytes express normal surface levels of activation markers, and show resistance to staurosporine and CD95-induced cell death.	Staurosporine	123-136	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	17-22
14698040-3	2004	Staurosporine (10-100nM) caused the activation of caspase-3.	Staurosporine	0-13	caspase 3	Homo sapiens	50-59
14698040-6	2004	VEGF or EGF (10-100ng/mL) added together with staurosporine decreased the activation of caspase-3.	Staurosporine	46-59	caspase 3	Homo sapiens	88-97
14698040-10	2004	Western blotting analysis showed that after 3hr of incubation with staurosporine the level of the anti-apoptotic protein Mcl-1 decreased and this effect was reverted by VEGF.	Staurosporine	67-80	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	121-126
14698040-10	2004	Western blotting analysis showed that after 3hr of incubation with staurosporine the level of the anti-apoptotic protein Mcl-1 decreased and this effect was reverted by VEGF.	Staurosporine	67-80	vascular endothelial growth factor A	Homo sapiens	169-173
14698040-11	2004	It is concluded that VEGF and EGF antagonize the pro-apoptotic action of staurosporine by the combined signalling of PI-3K and ERKs pathways.	Staurosporine	73-86	vascular endothelial growth factor A	Homo sapiens	21-25
14583630-3	2004	Viability assays showed that caspase-7-/- clones are more resistant to the common apoptosis-inducing drugs etoposide and staurosporine.	Staurosporine	121-134	caspase 7	Gallus gallus	29-38
14570892-0	2004	Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels.	Staurosporine	82-95	transformation related protein 53, pseudogene	Mus musculus	119-122
14570892-2	2004	We first confirmed our previous finding that staurosporine-induced caspase activation is increased by PrPc overexpression in HEK293 cells.	Staurosporine	45-58	prion protein	Homo sapiens	102-106
14699503-14	2004	HCC cells with high-level hSulf1 expression were sensitive to staurosporine- or cisplatin-induced apoptosis, whereas low expressing cells were resistant.	Staurosporine	62-75	sulfatase 1	Homo sapiens	26-32
15512768-4	2004	In contrast, aprotinin, cycloheximide, staurosporine, H7, and Go6976 could suppress MMP-2 secretion in all tissue cultures and also decrease MMP-9 production in all synovial and some meniscal cultures.	Staurosporine	39-52	matrix metallopeptidase 2	Homo sapiens	84-89
15512768-4	2004	In contrast, aprotinin, cycloheximide, staurosporine, H7, and Go6976 could suppress MMP-2 secretion in all tissue cultures and also decrease MMP-9 production in all synovial and some meniscal cultures.	Staurosporine	39-52	matrix metallopeptidase 9	Homo sapiens	141-146
14725623-7	2004	The apoptotic inducer staurosporine induced the appearance of known apoptotic markers [pyknotic nuclei and caspase-3 specific (120 kDa) alpha-fodrin cleavage fragment], events not reproduced with Zn2+ insults.	Staurosporine	22-35	spectrin, alpha, non-erythrocytic 1	Rattus norvegicus	136-148
14699503-15	2004	Transfection of hSulf1 into hSulf1-negative cells restored staurosporine and cisplatin sensitivity.	Staurosporine	59-72	sulfatase 1	Homo sapiens	16-22
14699503-15	2004	Transfection of hSulf1 into hSulf1-negative cells restored staurosporine and cisplatin sensitivity.	Staurosporine	59-72	sulfatase 1	Homo sapiens	28-34
14691682-7	2004	Staurosporine, a PKC inhibitor, also blocked the inhibition by PTH.	Staurosporine	0-13	parathyroid hormone	Homo sapiens	63-66
14691177-14	2004	A positive control treatment with staurosporine (STP) caused increased caspase-3 activity, which was inhibited by MG132.	Staurosporine	34-47	caspase 3	Mus musculus	71-80
14691177-14	2004	A positive control treatment with staurosporine (STP) caused increased caspase-3 activity, which was inhibited by MG132.	Staurosporine	49-52	caspase 3	Mus musculus	71-80
14584044-9	2004	In addition, staurosporine and a PKC beta inhibitor, LY379196, blocked VEGF-mediated dissociation of beta-catenin from VE-cadherin, diffusion of albumin across the endothelial cell monolayer, and translocation of PKC beta isoforms.	Staurosporine	13-26	vascular endothelial growth factor A	Homo sapiens	71-75
14584044-9	2004	In addition, staurosporine and a PKC beta inhibitor, LY379196, blocked VEGF-mediated dissociation of beta-catenin from VE-cadherin, diffusion of albumin across the endothelial cell monolayer, and translocation of PKC beta isoforms.	Staurosporine	13-26	catenin beta 1	Homo sapiens	101-113
14584044-9	2004	In addition, staurosporine and a PKC beta inhibitor, LY379196, blocked VEGF-mediated dissociation of beta-catenin from VE-cadherin, diffusion of albumin across the endothelial cell monolayer, and translocation of PKC beta isoforms.	Staurosporine	13-26	cadherin 5	Homo sapiens	119-130
14584044-9	2004	In addition, staurosporine and a PKC beta inhibitor, LY379196, blocked VEGF-mediated dissociation of beta-catenin from VE-cadherin, diffusion of albumin across the endothelial cell monolayer, and translocation of PKC beta isoforms.	Staurosporine	13-26	protein kinase C beta	Homo sapiens	213-221
14689449-4	2004	Both staurosporine and tumor necrosis factor-alpha (TNF-alpha) induced apoptosis and activated NSMase in a multiphasic manner in both OPC and HOG cells.	Staurosporine	5-18	sphingomyelin phosphodiesterase 2	Homo sapiens	95-101
14689449-9	2004	Proapoptotic drugs such as staurosporine promoted the translocation of NSMase to the raft fraction.	Staurosporine	27-40	sphingomyelin phosphodiesterase 2	Homo sapiens	71-77
14689449-10	2004	In contrast, ASMase, other lysosomal hydrolases, and caspase 3 remained absent from rafts even after staurosporine treatment.	Staurosporine	101-114	sphingomyelin phosphodiesterase 1	Homo sapiens	13-19
14689449-10	2004	In contrast, ASMase, other lysosomal hydrolases, and caspase 3 remained absent from rafts even after staurosporine treatment.	Staurosporine	101-114	caspase 3	Homo sapiens	53-62
14689449-11	2004	The staurosporine-induced concomitant increase of ceramide in the raft fraction and caspase 3 in the cytosol could be mimicked by the addition of exogenous bacterial SMase.	Staurosporine	4-17	caspase 3	Homo sapiens	84-93
14698758-0	2004	Effects of estrone on N-methyl-D-aspartic acid- and staurosporine-induced changes in caspase-3-like protease activity and lactate dehydrogenase-release: time- and tissue-dependent effects in neuronal primary cultures.	Staurosporine	52-65	caspase-3-like	Rattus norvegicus	85-99
15068669-0	2004	Upregulation of survivin in G2/M cells and inhibition of caspase 9 activity enhances resistance in staurosporine-induced apoptosis.	Staurosporine	99-112	caspase 9	Homo sapiens	57-66
15068669-8	2004	In our experimental system, STS induced apoptosis through the mitochondrial-caspase 9-mediated pathway.	Staurosporine	28-31	caspase 9	Homo sapiens	76-85
14698758-3	2004	In the present study we compared effects of estrone (100 and 500 nM) on N-methyl-D-aspartic acid (NMDA) (1 mM)- and staurosporine (1 microM)-induced caspase-3-like activity and lactate dehydrogenase (LDH)-release in primary cultures of rat hippocampal and neocortical neurons.	Staurosporine	116-129	caspase-3-like	Rattus norvegicus	149-163
14698758-11	2004	In contrast to NMDA, staurosporine elevated caspase-3-like activity and LDH-release in a time-dependent manner in all used culture systems.	Staurosporine	21-34	caspase-3-like	Rattus norvegicus	44-58
15327748-3	2004	GADD153 mRNA expression was immediately enhanced following hydrogen peroxide exposure and was significantly inhibited by treatment with H-7, staurosporin, and Ro-31-8220.	Staurosporine	141-153	DNA damage inducible transcript 3	Homo sapiens	0-7
12879265-7	2004	Staurosporine changed spontaneous IL-18 mRNA levels and increased the secretion of IL-18 protein.	Staurosporine	0-13	interleukin 18	Homo sapiens	34-39
12879265-7	2004	Staurosporine changed spontaneous IL-18 mRNA levels and increased the secretion of IL-18 protein.	Staurosporine	0-13	interleukin 18	Homo sapiens	83-88
15112431-10	2004	Our data indicate that (1) Pol eta is not phosphorylated in response to UV irradiation or MMS treatment, but its diffusional mobility is slightly decreased, and (2) hRad18 accumulates in MMS-treated cells, and considerable amount of the protein co-localizes with detergent insoluble PCNA in replication foci; these responses are sensitive to staurosporine.	Staurosporine	342-355	RAD18 E3 ubiquitin protein ligase	Homo sapiens	165-171
15112431-11	2004	Our data suggest that hRad18 phosphorylation is the staurosporine-sensitive PRR step.	Staurosporine	52-65	RAD18 E3 ubiquitin protein ligase	Homo sapiens	22-28
14530272-10	2003	Our results combined with these previous observations indicate that the N-terminal domain of Stt3p may interact with members of the Pkc1p cascade and consequently mutations in this domain result in staurosporine sensitivity.	Staurosporine	198-211	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	93-98
14570914-6	2003	Proteolytically derived fragments crossreactive with polyclonal anti-band 3 antibody appeared with simultaneous cleavage of poly (ADP-ribose) polymerase and procaspase 3 in staurosporine (STS)-treated HEK293 cells transiently transfected with CDB3 (5).	Staurosporine	173-186	poly(ADP-ribose) polymerase 1	Homo sapiens	124-152
14570914-6	2003	Proteolytically derived fragments crossreactive with polyclonal anti-band 3 antibody appeared with simultaneous cleavage of poly (ADP-ribose) polymerase and procaspase 3 in staurosporine (STS)-treated HEK293 cells transiently transfected with CDB3 (5).	Staurosporine	173-186	caspase 3	Homo sapiens	157-169
14570914-6	2003	Proteolytically derived fragments crossreactive with polyclonal anti-band 3 antibody appeared with simultaneous cleavage of poly (ADP-ribose) polymerase and procaspase 3 in staurosporine (STS)-treated HEK293 cells transiently transfected with CDB3 (5).	Staurosporine	188-191	poly(ADP-ribose) polymerase 1	Homo sapiens	124-152
14570914-6	2003	Proteolytically derived fragments crossreactive with polyclonal anti-band 3 antibody appeared with simultaneous cleavage of poly (ADP-ribose) polymerase and procaspase 3 in staurosporine (STS)-treated HEK293 cells transiently transfected with CDB3 (5).	Staurosporine	188-191	caspase 3	Homo sapiens	157-169
14663139-5	2003	Interestingly, we found that cells from EndoG heterozygous mutant mice exhibit increased resistance to both tumor necrosis factor alpha- and staurosporine-induced cell death.	Staurosporine	141-154	endonuclease G	Mus musculus	40-45
14530272-10	2003	Our results combined with these previous observations indicate that the N-terminal domain of Stt3p may interact with members of the Pkc1p cascade and consequently mutations in this domain result in staurosporine sensitivity.	Staurosporine	198-211	protein kinase C	Saccharomyces cerevisiae S288C	132-137
14664910-4	2003	In hippocampal neurons, E2 and BPA significantly inhibited the staurosporine-induced increase in caspase-3 activity.	Staurosporine	63-76	caspase 3	Rattus norvegicus	97-106
14680805-3	2003	Treatment of the antisense BAG-1-transfected cells with the anti-cancer drugs staurosporine, paclitaxel, all-trans retinoic acid (ATRA), and N-(4-hydroxyphenyl) retinamide (4-HPR) resulted in significantly enhanced apoptosis and reduced cell viability relative to vector-transfected cells.	Staurosporine	78-91	BAG cochaperone 1	Homo sapiens	27-32
14680805-6	2003	Treatment with staurosporine and paclitaxel resulted in increased cytochrome c release from mitochondria, whereas there was no change induced by treatment with ATRA and 4-HPR.	Staurosporine	15-28	cytochrome c, somatic	Homo sapiens	66-78
14653953-6	2003	KN-62 and staurosporine significantly blocked the opioids- induced CREB phosphorylation, while H-89 and PD 98059 had no effect on the actions.	Staurosporine	10-23	cAMP responsive element binding protein 1	Rattus norvegicus	67-71
12881220-11	2003	Furthermore, staurosporine, a nonselective PKC inhibitor, prevented the induction of VEGF by hypoxia.	Staurosporine	13-26	protein kinase C, gamma	Rattus norvegicus	43-46
12881220-11	2003	Furthermore, staurosporine, a nonselective PKC inhibitor, prevented the induction of VEGF by hypoxia.	Staurosporine	13-26	vascular endothelial growth factor A	Rattus norvegicus	85-89
15028619-6	2003	However, hIRAS expression led to prolonged cell survival against known apoptotic stimuli: serum starvation or thapsigargin or staurosporine treatments.	Staurosporine	126-139	nischarin	Homo sapiens	9-14
15033698-11	2003	Caspase 3 activity induced by LPS (24 h) or by staurosporin (6 h) was found to be dramatically downregulated by the G-CSF preincubation protocol.	Staurosporine	47-59	caspase 3	Homo sapiens	0-9
15033698-11	2003	Caspase 3 activity induced by LPS (24 h) or by staurosporin (6 h) was found to be dramatically downregulated by the G-CSF preincubation protocol.	Staurosporine	47-59	colony stimulating factor 3	Homo sapiens	116-121
15033752-2	2003	Stimulation of the kappa-opioid receptor expressed by cultured human epithelial cancer cells promotes staurosporine-induced apoptosis.	Staurosporine	102-115	opioid receptor kappa 1	Homo sapiens	19-40
14633855-6	2003	The relevance of using caspase-3 activation to indicate beta-cell apoptosis was demonstrated by inhibiting caspase-3-like proteases with Z-DEVD-fmk and thereby showing that caspase-3 activation was needed for high-glucose-and cytokine-induced apoptosis in the beta-cell and for staurosporine-induced apoptosis in RINm5F cells.	Staurosporine	278-291	caspase 3	Rattus norvegicus	23-32
14681550-5	2003	Using staurosporine, TNF-alpha plus cycloheximide, and gamma-radiations, we observed that ACH-2 were more sensitive to programmed cell death than A301, while U1 were less sensitive than U937.	Staurosporine	6-19	acyl-CoA thioesterase 1	Homo sapiens	90-95
14622091-6	2003	Treatment of PC12 cells with staurosporine induces gal-3 expression and neurite outgrowth without ERK1/2 activation.	Staurosporine	29-42	galectin 3	Rattus norvegicus	51-56
14622091-7	2003	NGF- and staurosporine-induced gal-3-expression is also regulated at the transcriptional level.	Staurosporine	9-22	galectin 3	Rattus norvegicus	31-36
14622091-9	2003	Staurosporine, in contrast, induces gal-3 expression by a Ras/MAPK-independent mechanism.	Staurosporine	0-13	galectin 3	Rattus norvegicus	36-41
14597411-5	2003	dibutyryl cyclic AMP (dbcAMP), staurosporine, and HMBA have greater growth inhibitory effect on fra-1 overexpressing clones as compared to the parental C6 cells.	Staurosporine	31-44	FOS like 1, AP-1 transcription factor subunit	Rattus norvegicus	96-101
14597411-6	2003	dbcAMP and staurosporine not only inhibit proliferation but bring about complete apoptosis of fra-1 overexpressing clones.	Staurosporine	11-24	FOS like 1, AP-1 transcription factor subunit	Rattus norvegicus	94-99
14633690-8	2003	The reduction in A1/A2 levels in HeLa cells was associated with a change in the distribution of the lengths of G-tails, an event not observed when apoptosis was induced with staurosporine.	Staurosporine	174-187	BCL2 related protein A1	Homo sapiens	17-22
14522134-10	2003	The non-selective PKC inhibitors, staurosporine and Ro31-8220, significantly reduced histamine-induced superoxide production.	Staurosporine	34-47	protein kinase C alpha	Homo sapiens	18-21
12947090-6	2003	Treatment of HepG2 cells with the PKC inhibitors staurosporine and calphostin C repressed ARE-mediated induction of a luciferase reporter as well as that of the endogenous NQO1 gene.	Staurosporine	49-62	proline rich transmembrane protein 2	Homo sapiens	34-37
12947090-6	2003	Treatment of HepG2 cells with the PKC inhibitors staurosporine and calphostin C repressed ARE-mediated induction of a luciferase reporter as well as that of the endogenous NQO1 gene.	Staurosporine	49-62	NAD(P)H quinone dehydrogenase 1	Homo sapiens	172-176
12947090-8	2003	The PKC inhibitor staurosporine blocked the nuclear translocation of Nrf2, suggesting that Nrf2 might be the target for PKC regulation.	Staurosporine	18-31	proline rich transmembrane protein 2	Homo sapiens	4-7
12947090-8	2003	The PKC inhibitor staurosporine blocked the nuclear translocation of Nrf2, suggesting that Nrf2 might be the target for PKC regulation.	Staurosporine	18-31	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
12947090-8	2003	The PKC inhibitor staurosporine blocked the nuclear translocation of Nrf2, suggesting that Nrf2 might be the target for PKC regulation.	Staurosporine	18-31	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
12947090-8	2003	The PKC inhibitor staurosporine blocked the nuclear translocation of Nrf2, suggesting that Nrf2 might be the target for PKC regulation.	Staurosporine	18-31	proline rich transmembrane protein 2	Homo sapiens	120-123
14563490-0	2003	Induction by staurosporine of hepatocyte growth factor production in human skin fibroblasts independent of protein kinase inhibition.	Staurosporine	13-26	hepatocyte growth factor	Homo sapiens	30-54
14563490-2	2003	We now report that staurosporine can induce the production of hepatocyte growth factor (HGF) independently of protein kinase inhibition.	Staurosporine	19-32	hepatocyte growth factor	Homo sapiens	62-86
14563490-2	2003	We now report that staurosporine can induce the production of hepatocyte growth factor (HGF) independently of protein kinase inhibition.	Staurosporine	19-32	hepatocyte growth factor	Homo sapiens	88-91
14563490-3	2003	Staurosporine markedly stimulated the production of HGF in various cell types, including human skin fibroblasts.	Staurosporine	0-13	hepatocyte growth factor	Homo sapiens	52-55
14563490-6	2003	UCN-01, 7-hydroxystaurosporine, which differs from staurosporine only in its aglycone moiety, also showed HGF-inducing activity, and inactive K-252a differs from staurosporine only in its sugar moiety.	Staurosporine	17-30	hepatocyte growth factor	Homo sapiens	106-109
14563490-7	2003	These results indicate that the sugar moiety, a six-atom ring structure, is important in the HGF-inducing activity of staurosporine.	Staurosporine	118-131	hepatocyte growth factor	Homo sapiens	93-96
14563490-8	2003	Experiments were then carried out to determine whether the characteristics of staurosporine-induced HGF production have similarities to those of HGF production stimulated by other HGF inducers.	Staurosporine	78-91	hepatocyte growth factor	Homo sapiens	100-103
14563490-10	2003	The net increase in HGF production induced by staurosporine was not reduced in protein kinase C-depleted human skin fibroblasts.	Staurosporine	46-59	hepatocyte growth factor	Homo sapiens	20-23
14563490-11	2003	Moreover, synergistic induction of HGF was detected between staurosporine and interferon-gamma as well as between 8-bromo-cAMP and interferon-gamma.	Staurosporine	60-73	hepatocyte growth factor	Homo sapiens	35-38
14563490-13	2003	These results indicate that staurosporine induced HGF in different cell types via a signaling pathway similar to the cAMP-mediated pathway without increasing cAMP levels.	Staurosporine	28-41	hepatocyte growth factor	Homo sapiens	50-53
14576777-0	2003	Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine.	Staurosporine	106-119	cathepsin D	Homo sapiens	0-11
14576777-0	2003	Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine.	Staurosporine	106-119	cytochrome c, somatic	Homo sapiens	21-33
14576777-2	2003	In the present study, we present data that suggest a role for cathepsin D in staurosporine-induced apoptosis in human foreskin fibroblasts.	Staurosporine	77-90	cathepsin D	Homo sapiens	62-73
14576777-3	2003	Cathepsin D and cytochrome c were detected partially released to the cytosol after exposure to 0.1 muM staurosporine for 1 h. After 4 h, activation of caspase-9 and -3 was initiated and later caspase-8 activation and a decrease in full-length Bid were detected.	Staurosporine	103-116	cathepsin D	Homo sapiens	0-11
14576777-3	2003	Cathepsin D and cytochrome c were detected partially released to the cytosol after exposure to 0.1 muM staurosporine for 1 h. After 4 h, activation of caspase-9 and -3 was initiated and later caspase-8 activation and a decrease in full-length Bid were detected.	Staurosporine	103-116	cytochrome c, somatic	Homo sapiens	16-28
14576777-3	2003	Cathepsin D and cytochrome c were detected partially released to the cytosol after exposure to 0.1 muM staurosporine for 1 h. After 4 h, activation of caspase-9 and -3 was initiated and later caspase-8 activation and a decrease in full-length Bid were detected.	Staurosporine	103-116	latexin	Homo sapiens	99-102
14576777-3	2003	Cathepsin D and cytochrome c were detected partially released to the cytosol after exposure to 0.1 muM staurosporine for 1 h. After 4 h, activation of caspase-9 and -3 was initiated and later caspase-8 activation and a decrease in full-length Bid were detected.	Staurosporine	103-116	caspase 9	Homo sapiens	151-167
14576777-3	2003	Cathepsin D and cytochrome c were detected partially released to the cytosol after exposure to 0.1 muM staurosporine for 1 h. After 4 h, activation of caspase-9 and -3 was initiated and later caspase-8 activation and a decrease in full-length Bid were detected.	Staurosporine	103-116	caspase 8	Homo sapiens	192-201
14576777-3	2003	Cathepsin D and cytochrome c were detected partially released to the cytosol after exposure to 0.1 muM staurosporine for 1 h. After 4 h, activation of caspase-9 and -3 was initiated and later caspase-8 activation and a decrease in full-length Bid were detected.	Staurosporine	103-116	BH3 interacting domain death agonist	Homo sapiens	243-246
14576777-5	2003	These results imply that cytosolic cathepsin D is a key mediator in staurosporine-induced apoptosis.	Staurosporine	68-81	cathepsin D	Homo sapiens	35-46
14586407-3	2003	We further demonstrate that IL-6 protects an esophageal carcinoma cell line CE48T/VGH from apoptosis induced by staurosporine.	Staurosporine	112-125	interleukin 6	Homo sapiens	28-32
14766067-1	2003	OBJECTIVE: To study the effects of staurosporine (ST), an inhibitor of protein kinase C (PKC), on the cell cycle of cultured human keratocyte at G(1)/S phase transition and to study the molecular mechanism of this process.	Staurosporine	35-48	proline rich transmembrane protein 2	Homo sapiens	71-87
14766067-1	2003	OBJECTIVE: To study the effects of staurosporine (ST), an inhibitor of protein kinase C (PKC), on the cell cycle of cultured human keratocyte at G(1)/S phase transition and to study the molecular mechanism of this process.	Staurosporine	35-48	proline rich transmembrane protein 2	Homo sapiens	89-92
14766067-1	2003	OBJECTIVE: To study the effects of staurosporine (ST), an inhibitor of protein kinase C (PKC), on the cell cycle of cultured human keratocyte at G(1)/S phase transition and to study the molecular mechanism of this process.	Staurosporine	50-52	proline rich transmembrane protein 2	Homo sapiens	71-87
14766067-1	2003	OBJECTIVE: To study the effects of staurosporine (ST), an inhibitor of protein kinase C (PKC), on the cell cycle of cultured human keratocyte at G(1)/S phase transition and to study the molecular mechanism of this process.	Staurosporine	50-52	proline rich transmembrane protein 2	Homo sapiens	89-92
12892559-3	2003	Here, we report the crystal structures of staurosporine and UCN-01 in complex with the kinase domain of PDK1.	Staurosporine	42-55	3-phosphoinositide dependent protein kinase 1	Homo sapiens	104-108
12892559-4	2003	We show that, although staurosporine and UCN-01 interact with the PDK1 active site in an overall similar manner, the UCN-01 7-hydroxy group, which is not present in staurosporine, generates direct and water-mediated hydrogen bonds with active-site residues.	Staurosporine	23-36	3-phosphoinositide dependent protein kinase 1	Homo sapiens	66-70
12902337-3	2003	Functional assays of KCl cotransport activation by osmotic swelling, staurosporine, and N-ethylmaleimide indicate that removal of the N-terminal 117 amino acids from KCC1 produces a dominant-negative loss-of-function phenotype for KCl cotransport in human cervical cancer cells.	Staurosporine	69-82	solute carrier family 12 member 4	Homo sapiens	166-170
12904305-5	2003	TIMP-1-activated cell survival signaling down-regulates caspase-mediated classical apoptotic pathways induced by a variety of stimuli including anoikis, staurosporine exposure, and growth factor withdrawal.	Staurosporine	153-166	TIMP metallopeptidase inhibitor 1	Homo sapiens	0-6
14511641-3	2003	During staurosporine-, Fas-, and tumor necrosis factor alpha-induced apoptosis caspase-processed activated CDK11(p46) is generated from larger CDK11(p110) isoforms.	Staurosporine	7-20	tumor necrosis factor	Homo sapiens	23-60
12832423-6	2003	When combined with protein kinase C inhibition by staurosporine or rottlerin, breakdown of plasma membrane sphingomyelin or enrichment of the plasma membrane with ceramide also increased IL-6R shedding.	Staurosporine	50-63	interleukin 6 receptor	Homo sapiens	187-192
14511641-3	2003	During staurosporine-, Fas-, and tumor necrosis factor alpha-induced apoptosis caspase-processed activated CDK11(p46) is generated from larger CDK11(p110) isoforms.	Staurosporine	7-20	cyclin dependent kinase 19	Homo sapiens	107-112
14511641-3	2003	During staurosporine-, Fas-, and tumor necrosis factor alpha-induced apoptosis caspase-processed activated CDK11(p46) is generated from larger CDK11(p110) isoforms.	Staurosporine	7-20	cyclin dependent kinase 19	Homo sapiens	143-148
14511641-3	2003	During staurosporine-, Fas-, and tumor necrosis factor alpha-induced apoptosis caspase-processed activated CDK11(p46) is generated from larger CDK11(p110) isoforms.	Staurosporine	7-20	endogenous retrovirus group K member 15	Homo sapiens	149-153
12932699-8	2003	Vincristine and rhodamine B was used as p-gp substrates and verapamil or staurosporine (ST) as inhibitors of p-gp transport.	Staurosporine	73-86	ATP binding cassette subfamily B member 1	Homo sapiens	109-113
12932699-8	2003	Vincristine and rhodamine B was used as p-gp substrates and verapamil or staurosporine (ST) as inhibitors of p-gp transport.	Staurosporine	88-90	ATP binding cassette subfamily B member 1	Homo sapiens	109-113
14514014-9	2003	In addition, TGF-beta1 has been recently characterized as an antiapoptotic factor in a model of staurosporine-induced neuronal death through a mechanism involving activation of the extracellular signal-regulated kinase 1/2 (Erk1/2) and a concomitant increase phosphorylation of the antiapoptotic protein Bad.	Staurosporine	96-109	mitogen-activated protein kinase 1	Homo sapiens	181-222
14530272-2	2003	Over a decade ago, the gene STT3 was identified in a staurosporine and temperature sensitivity screen of yeast.	Staurosporine	53-66	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	28-32
14530272-5	2003	Staurosporine sensitivity was found to be an allele-specific phenotype restricted to cells harboring mutations in highly conserved residues in the N-terminal domain of the STT3 protein.	Staurosporine	0-13	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	172-176
14530272-6	2003	Cells bearing mutations in one of the cytosolic-oriented loops (amino acids 158-168) in the N terminus of Stt3p were found to be specifically susceptible to staurosporine.	Staurosporine	157-170	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	106-111
14530272-7	2003	Staurosporine is a specific inhibitor of Pkc1p, and a genetic link had previously been suggested between PKC1 and STT3.	Staurosporine	0-13	protein kinase C	Saccharomyces cerevisiae S288C	41-46
14530272-8	2003	It is known that overexpression of PKC1 suppresses the staurosporine sensitivity of the stt3 mutants in an allele-specific manner, which is typical of mutants of Pkc1p cascade.	Staurosporine	55-68	protein kinase C	Saccharomyces cerevisiae S288C	35-39
14530272-8	2003	It is known that overexpression of PKC1 suppresses the staurosporine sensitivity of the stt3 mutants in an allele-specific manner, which is typical of mutants of Pkc1p cascade.	Staurosporine	55-68	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3	Saccharomyces cerevisiae S288C	88-92
14530272-8	2003	It is known that overexpression of PKC1 suppresses the staurosporine sensitivity of the stt3 mutants in an allele-specific manner, which is typical of mutants of Pkc1p cascade.	Staurosporine	55-68	protein kinase C	Saccharomyces cerevisiae S288C	162-167
14514014-9	2003	In addition, TGF-beta1 has been recently characterized as an antiapoptotic factor in a model of staurosporine-induced neuronal death through a mechanism involving activation of the extracellular signal-regulated kinase 1/2 (Erk1/2) and a concomitant increase phosphorylation of the antiapoptotic protein Bad.	Staurosporine	96-109	transforming growth factor beta 1	Homo sapiens	13-22
14514014-9	2003	In addition, TGF-beta1 has been recently characterized as an antiapoptotic factor in a model of staurosporine-induced neuronal death through a mechanism involving activation of the extracellular signal-regulated kinase 1/2 (Erk1/2) and a concomitant increase phosphorylation of the antiapoptotic protein Bad.	Staurosporine	96-109	mitogen-activated protein kinase 3	Homo sapiens	224-230
14557487-7	2003	In cultured granulosa-luteal cells, FSH and LH treatment increased dose-dependently the accumulation of betaglycan mRNA, as did the protein kinase A activator dibutyryl cAMP and the protein kinase C inhibitor staurosporine.	Staurosporine	209-222	transforming growth factor beta receptor 3	Homo sapiens	104-114
14505317-6	2003	RESULTS: We have successfully applied the assays to evaluate (a) activation of E-selectin (CD62E) expression by interleukin-1beta in human umbilical vein endothelial cells (HUVECs), (b) induction of CD3 by phorbol-12-myristate-13-acetate in freshly prepared human peripheral blood lymphocytes, and (c) staurosporine-induced apoptosis in HUVEC and normal human dermal fibroblasts.	Staurosporine	302-315	selectin E	Homo sapiens	79-89
14505317-6	2003	RESULTS: We have successfully applied the assays to evaluate (a) activation of E-selectin (CD62E) expression by interleukin-1beta in human umbilical vein endothelial cells (HUVECs), (b) induction of CD3 by phorbol-12-myristate-13-acetate in freshly prepared human peripheral blood lymphocytes, and (c) staurosporine-induced apoptosis in HUVEC and normal human dermal fibroblasts.	Staurosporine	302-315	selectin E	Homo sapiens	91-96
12942541-5	2003	The Ang II-evoked c-fos induction was blocked only by high doses of staurosporine and by zeta-PS whilst PD098059, LY294002 and wortmannin were ineffective, thus indicating that c-fos induction is not due to ERK1/2 activity.	Staurosporine	68-81	angiogenin	Homo sapiens	4-7
12942541-5	2003	The Ang II-evoked c-fos induction was blocked only by high doses of staurosporine and by zeta-PS whilst PD098059, LY294002 and wortmannin were ineffective, thus indicating that c-fos induction is not due to ERK1/2 activity.	Staurosporine	68-81	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
12860017-3	2003	Several staurosporines increased, dose- and time-dependently, the IL-8 and MCP-1 concentration in the cell culture supernatants and three derivatives strongly inhibited proliferation of the NB-4 cells.	Staurosporine	8-22	chemokine (C-X-C motif) ligand 15	Mus musculus	66-70
12860017-3	2003	Several staurosporines increased, dose- and time-dependently, the IL-8 and MCP-1 concentration in the cell culture supernatants and three derivatives strongly inhibited proliferation of the NB-4 cells.	Staurosporine	8-22	chemokine (C-C motif) ligand 2	Mus musculus	75-80
12860017-2	2003	We evaluated nine naturally occurring staurosporine derivatives as modulators of chemokine production by monitoring the secretion of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) in the cell line NB-4.	Staurosporine	38-51	chemokine (C-X-C motif) ligand 15	Mus musculus	133-146
12860017-2	2003	We evaluated nine naturally occurring staurosporine derivatives as modulators of chemokine production by monitoring the secretion of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) in the cell line NB-4.	Staurosporine	38-51	chemokine (C-X-C motif) ligand 15	Mus musculus	148-152
12860017-2	2003	We evaluated nine naturally occurring staurosporine derivatives as modulators of chemokine production by monitoring the secretion of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) in the cell line NB-4.	Staurosporine	38-51	chemokine (C-C motif) ligand 2	Mus musculus	190-195
12860017-4	2003	By comparing the efficiency of these analogues at the same concentration, the lead compound staurosporine (STS-1) was the best inducer of chemokine secretion, whereas 3-hydroxystaurosporine (STS-3) was the most potent growth inhibitor.	Staurosporine	92-105	E74 like ETS transcription factor 1	Mus musculus	107-112
12860017-6	2003	Several staurosporine analogues clearly inhibited the TPA-induced but enhanced the TNFalpha-mediated chemokine increase.	Staurosporine	8-21	tumor necrosis factor	Mus musculus	83-91
14508514-4	2003	We demonstrate that human Rad9 can be specifically cleaved in cells induced to enter apoptosis by both DNA damage and staurosporine treatment.	Staurosporine	118-131	RAD9 checkpoint clamp component A	Homo sapiens	26-30
14507967-7	2003	When cultured oligodendrocytes were exposed to staurosporine or cyclosporin A, drugs known to stimulate apoptosis in oligodendrocytes, those from Bax-/- mice but not from Bax+/+ or Bax+/- mice were resistant to the apoptotic death.	Staurosporine	47-60	BCL2-associated X protein	Mus musculus	146-149
12941295-2	2003	In this report, we studied the changes in Mcl-1 protein and mRNA expression induced by staurosporine and aspirin.	Staurosporine	87-100	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	42-47
12941295-5	2003	Staurosporine also reduced Mcl-1 mRNA levels and this reduction was mostly caspase-dependent.	Staurosporine	0-13	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	27-32
12941295-6	2003	In addition, staurosporine reduced the transcriptional activity of the Mcl-1 promoter fused to a luciferase gene reporter more than actinomycin D, a general inhibitor of transcription.	Staurosporine	13-26	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	71-76
12941295-7	2003	Thus, we conclude that staurosporine down-regulates Mcl-1 mRNA levels by inhibiting transcription in a caspase-dependent manner and reduces Mcl-1 protein levels by a caspase-independent post-transcriptional mechanism.	Staurosporine	23-36	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	52-57
12941295-7	2003	Thus, we conclude that staurosporine down-regulates Mcl-1 mRNA levels by inhibiting transcription in a caspase-dependent manner and reduces Mcl-1 protein levels by a caspase-independent post-transcriptional mechanism.	Staurosporine	23-36	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	140-145
12941295-14	2003	Mcl-1 disappearance might be necessary but not sufficient for the induction of apoptosis by staurosporine and aspirin.	Staurosporine	92-105	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	0-5
12738667-3	2003	Overexpression of Hsp70 significantly augmented the apoptotic cell death as well as DNA fragmentation in CD3/CD28- or staurosporine-stimulated cells.	Staurosporine	118-131	heat shock protein family A (Hsp70) member 4	Homo sapiens	18-23
12738667-4	2003	Following stimulation of cells with CD3/CD28 or staurosporine, Hsp70 was coprecipitated with free CAD, but not with CAD associated with ICAD.	Staurosporine	48-61	heat shock protein family A (Hsp70) member 4	Homo sapiens	63-68
12738667-4	2003	Following stimulation of cells with CD3/CD28 or staurosporine, Hsp70 was coprecipitated with free CAD, but not with CAD associated with ICAD.	Staurosporine	48-61	aconitate decarboxylase 1	Homo sapiens	98-101
12738667-9	2003	Finally, CAD that had been coprecipitated with Hsp70 from the cell lysate of staurosporine-activated 293T cells induced chromatin DNA fragmentation and its activity was not inhibited by ICAD.	Staurosporine	77-90	aconitate decarboxylase 1	Homo sapiens	9-12
12738667-9	2003	Finally, CAD that had been coprecipitated with Hsp70 from the cell lysate of staurosporine-activated 293T cells induced chromatin DNA fragmentation and its activity was not inhibited by ICAD.	Staurosporine	77-90	heat shock protein family A (Hsp70) member 4	Homo sapiens	47-52
12911616-4	2003	We found that SK2 or Kv1.1 protected not only against kainate or glutamate excitotoxicity but also increased survival after sodium cyanide or staurosporine.	Staurosporine	142-155	potassium calcium-activated channel subfamily N member 2	Homo sapiens	14-17
12911616-4	2003	We found that SK2 or Kv1.1 protected not only against kainate or glutamate excitotoxicity but also increased survival after sodium cyanide or staurosporine.	Staurosporine	142-155	potassium voltage-gated channel subfamily A member 1	Homo sapiens	21-26
12816972-6	2003	In turn in the adult, but not fetus, protein kinase C (PKC) inhibition by staurosporine (3 x 10(-8) M) prior to ERK1/2 inhibition by U-0126 (10(-5) M) prevented this elimination of [Ca2+]i increase.	Staurosporine	74-87	proline rich transmembrane protein 2	Homo sapiens	37-53
12816972-6	2003	In turn in the adult, but not fetus, protein kinase C (PKC) inhibition by staurosporine (3 x 10(-8) M) prior to ERK1/2 inhibition by U-0126 (10(-5) M) prevented this elimination of [Ca2+]i increase.	Staurosporine	74-87	proline rich transmembrane protein 2	Homo sapiens	55-58
12805640-3	2003	Staurosporine has also been reported as a myosin light chain kinase (MLCK) inhibitor, so we tested whether the MLCK pathway was involved in the effect of MEPE.	Staurosporine	0-13	myosin light chain kinase	Rattus norvegicus	42-67
12805640-3	2003	Staurosporine has also been reported as a myosin light chain kinase (MLCK) inhibitor, so we tested whether the MLCK pathway was involved in the effect of MEPE.	Staurosporine	0-13	myosin light chain kinase	Rattus norvegicus	69-73
12805640-3	2003	Staurosporine has also been reported as a myosin light chain kinase (MLCK) inhibitor, so we tested whether the MLCK pathway was involved in the effect of MEPE.	Staurosporine	0-13	myosin light chain kinase	Rattus norvegicus	111-115
12821679-7	2003	Activation of the PTK was blocked when gametes underwent flagellar adhesion in the presence of the protein kinase inhibitor staurosporine, but not in the presence of the cyclic nucleotide-dependent protein kinase inhibitor, H8, which (unlike staurosporine) does not block the increases in cAMP.	Staurosporine	124-137	EPH receptor A8	Homo sapiens	18-21
12821679-7	2003	Activation of the PTK was blocked when gametes underwent flagellar adhesion in the presence of the protein kinase inhibitor staurosporine, but not in the presence of the cyclic nucleotide-dependent protein kinase inhibitor, H8, which (unlike staurosporine) does not block the increases in cAMP.	Staurosporine	242-255	EPH receptor A8	Homo sapiens	18-21
14575590-9	2003	Staurosporine (2.5 x 10(-7) mol/L) and genistein (4 x 10(-5) mol/L) lowered TF level of monocytes (P &lt; 0.05).	Staurosporine	0-13	coagulation factor III, tissue factor	Homo sapiens	76-78
12796501-8	2003	Although wortmannin, LY294002, and actinomycin D blocked the increase in SHARP-2 mRNA levels by insulin, rapamycin, staurosporine, PD98059, okadaic acid, and 8-bromocyclic AMP had no effect.	Staurosporine	116-129	basic helix-loop-helix family, member e40	Rattus norvegicus	73-80
12902488-2	2003	In this study, we demonstrated that various pathogen-associated molecular patterns up-regulated Fas expression in macrophages and sensitized them specifically to Fas ligand (FasL), but not to other apoptosis-inducing agents such as TNF-alpha, etoposide (VP-16), and staurosporine.	Staurosporine	266-279	Fas ligand (TNF superfamily, member 6)	Mus musculus	162-172
12902488-2	2003	In this study, we demonstrated that various pathogen-associated molecular patterns up-regulated Fas expression in macrophages and sensitized them specifically to Fas ligand (FasL), but not to other apoptosis-inducing agents such as TNF-alpha, etoposide (VP-16), and staurosporine.	Staurosporine	266-279	Fas ligand (TNF superfamily, member 6)	Mus musculus	174-178
12853106-4	2003	In addition, N-WASP, WISH and WAVE were co-localized with filamentous actin in abnormal dendrite-like processes sprouting from staurosporine-treated human SH-SY5Y cells.	Staurosporine	127-140	WASP like actin nucleation promoting factor	Homo sapiens	13-19
12853106-4	2003	In addition, N-WASP, WISH and WAVE were co-localized with filamentous actin in abnormal dendrite-like processes sprouting from staurosporine-treated human SH-SY5Y cells.	Staurosporine	127-140	NCK interacting protein with SH3 domain	Homo sapiens	21-25
12781872-5	2003	Following treatment with staurosporine, also an inducer of apoptosis, mIL-1RAcP mRNA levels steadily decrease through 72 h, with little change in sIL-1RAcP mRNA levels.	Staurosporine	25-38	interleukin 1 receptor accessory protein	Mus musculus	70-79
13678665-5	2003	Although both staurosporine and 6-OHDA induced apoptosis, overexpression of Bcl-2 only rescued cells from programmed cell death induced by staurosporine.	Staurosporine	14-27	BCL2 apoptosis regulator	Homo sapiens	76-81
13678665-5	2003	Although both staurosporine and 6-OHDA induced apoptosis, overexpression of Bcl-2 only rescued cells from programmed cell death induced by staurosporine.	Staurosporine	139-152	BCL2 apoptosis regulator	Homo sapiens	76-81
12867415-2	2003	We show that in basal and staurosporine-induced conditions the number of terminal deoxynucleotidyltransferase-mediated dUTP nick end-labeling (TUNEL)-positive beta-synuclein-expressing neurons was drastically lower than in mock-transfected TSM1 cells.	Staurosporine	26-39	synuclein, beta	Mus musculus	159-173
12867415-4	2003	beta-Synuclein strongly reduces staurosporine-induced caspase 3 activity and immunoreactivity.	Staurosporine	32-45	synuclein, beta	Mus musculus	0-14
12867415-4	2003	beta-Synuclein strongly reduces staurosporine-induced caspase 3 activity and immunoreactivity.	Staurosporine	32-45	caspase 3	Mus musculus	54-63
12867415-10	2003	Altogether, our data document for the first time that beta-synuclein protects neurons from staurosporine and 6OHDA-stimulated caspase activation in a p53-dependent manner.	Staurosporine	91-104	synuclein, beta	Mus musculus	54-68
12867415-10	2003	Altogether, our data document for the first time that beta-synuclein protects neurons from staurosporine and 6OHDA-stimulated caspase activation in a p53-dependent manner.	Staurosporine	91-104	transformation related protein 53, pseudogene	Mus musculus	150-153
12890758-3	2003	In cultured human keratinocytes seeded on fibronectin, we found that protein-serine/threonine kinase inhibitors including staurosporine, induced concentration-dependent formation of extended lamellipodia (E-lams).	Staurosporine	122-135	fibronectin 1	Homo sapiens	42-53
12890758-5	2003	Staurosporine treatment induced relocation of tyrosine phosphorylated phospholipase C-gamma1 (PLC-gamma1) to the tips of lamellipodia where actin assembly was initiated.	Staurosporine	0-13	phospholipase C gamma 1	Homo sapiens	70-92
12890758-5	2003	Staurosporine treatment induced relocation of tyrosine phosphorylated phospholipase C-gamma1 (PLC-gamma1) to the tips of lamellipodia where actin assembly was initiated.	Staurosporine	0-13	phospholipase C gamma 1	Homo sapiens	94-104
12890758-7	2003	Notably, glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) was activated by staurosporine as evidenced by reduced phosphorylation on Ser-21/9.	Staurosporine	81-94	glycogen synthase kinase 3 alpha	Homo sapiens	9-45
12890758-7	2003	Notably, glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) was activated by staurosporine as evidenced by reduced phosphorylation on Ser-21/9.	Staurosporine	81-94	glycogen synthase kinase 3 alpha	Homo sapiens	47-57
12914969-7	2003	Laser confocal microscopy of hippocampal neuron cultures undergoing apoptosis induced by amyloid beta peptide (Abeta) or staurosporine demonstrated significant time-dependent elevations of WT1 correlating with increased levels of apoptosis.	Staurosporine	121-134	WT1 transcription factor	Homo sapiens	189-192
12914969-8	2003	Blockade of WT1 transcription by antisense oligonucleotide reduced WT1 expression and prevented neuronal apoptosis in both Abeta- and staurosporine-treated cultures.	Staurosporine	134-147	WT1 transcription factor	Homo sapiens	12-15
12970105-11	2003	Staurosporine also induces rapid phosphorylation of ERK and p38, and inhibitors of both these enzymes block aggregation.	Staurosporine	0-13	mitogen-activated protein kinase 14	Homo sapiens	60-63
14500366-6	2003	Furthermore, annexin-V staining showed that RASSF1A-expressing cells had an increased sensitivity to staurosporine-induced apoptosis.	Staurosporine	101-114	annexin A5	Homo sapiens	13-22
14500366-6	2003	Furthermore, annexin-V staining showed that RASSF1A-expressing cells had an increased sensitivity to staurosporine-induced apoptosis.	Staurosporine	101-114	Ras association domain family member 1	Homo sapiens	44-51
12898009-8	2003	The reduced Ca2+ entry in diabetic microvessels was reversed by 2-h exposure to 100 nmol/l staurosporine, a non-specific PKC antagonist and was mimicked in microvessels from non-diabetic rats by 10-min exposure to the PKC activator phorbol myristate acetate (100 nmol/l).	Staurosporine	91-104	protein kinase C, beta	Rattus norvegicus	121-124
12898009-8	2003	The reduced Ca2+ entry in diabetic microvessels was reversed by 2-h exposure to 100 nmol/l staurosporine, a non-specific PKC antagonist and was mimicked in microvessels from non-diabetic rats by 10-min exposure to the PKC activator phorbol myristate acetate (100 nmol/l).	Staurosporine	91-104	protein kinase C, beta	Rattus norvegicus	218-221
12956724-9	2003	Pertussis toxin (PTX), antagonist of Gi/o-proteins, and inhibitors of phosphatidylcholine specific PLC (D609) and PKC (staurosporine or chelerythrine) prevented the effect of ATP while blockers of PLA2 (OBAA) and COX (aspirin or indomethacin) attenuated it.	Staurosporine	119-132	phospholipase A2 group IB	Homo sapiens	197-201
12956724-9	2003	Pertussis toxin (PTX), antagonist of Gi/o-proteins, and inhibitors of phosphatidylcholine specific PLC (D609) and PKC (staurosporine or chelerythrine) prevented the effect of ATP while blockers of PLA2 (OBAA) and COX (aspirin or indomethacin) attenuated it.	Staurosporine	119-132	cytochrome c oxidase subunit 8A	Homo sapiens	213-216
12887687-5	2003	The protein kinase C inhibitors, staurosporine and calphostin C, and the tyrosine kinase inhibitor genistein, but not its inactive analogue daidzein, prevented the induction of CYP2E1 by PDBu.	Staurosporine	33-46	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	177-183
12756251-11	2003	Moreover, the protein kinase C inhibitors staurosporine and GF109203X blocked the coumermycin-induced desensitization of hPAFR-GyrB, suggesting the implication of protein kinase C in the molecular mechanism mediating the agonist-independent desensitization of the receptor.	Staurosporine	42-55	platelet activating factor receptor	Homo sapiens	121-126
12874265-6	2003	Smac or a Smac-derived agonistic peptide also sensitized intact HL-derived B cells for the apoptotic action of staurosporine.	Staurosporine	111-124	diablo IAP-binding mitochondrial protein	Homo sapiens	0-4
12874265-6	2003	Smac or a Smac-derived agonistic peptide also sensitized intact HL-derived B cells for the apoptotic action of staurosporine.	Staurosporine	111-124	diablo IAP-binding mitochondrial protein	Homo sapiens	10-14
12814625-6	2003	Degradation of hY1 could also be demonstrated after treatment of A549 lung carcinoma cells treated with Staurosporin, Paclitaxel, or the histone deacetylase inhibitor LAQ824.	Staurosporine	104-116	RNA, Ro60-associated Y1	Homo sapiens	15-18
12881712-3	2003	FOXO3a was cleaved in vivo by caspases in leukemic Jurkat cells following engagement of Fas (CD95) receptor, staurosporine, and etoposide treatment, but not following engagement of CD99, a caspase-independent cell death inducer.	Staurosporine	109-122	forkhead box O3	Homo sapiens	0-6
12881712-3	2003	FOXO3a was cleaved in vivo by caspases in leukemic Jurkat cells following engagement of Fas (CD95) receptor, staurosporine, and etoposide treatment, but not following engagement of CD99, a caspase-independent cell death inducer.	Staurosporine	109-122	caspase 8	Homo sapiens	30-38
12852832-6	2003	A "ladder" pattern representing fragmentation of DNA into oligonucleosome length fragments was observed after 6 h of staurosporine treatment and sustained until 24 h. The Bax expression increased significantly at 6 h after exposure to staurosporine, peaked at 12 h compared with vehicle cultures, and decreased at 24 h. The Bcl-2 expression increased and reached the highest level at 3 h. It was then decreased gradually but still higher than normal expression level.	Staurosporine	117-130	BCL2-associated X protein	Mus musculus	171-174
12852832-6	2003	A "ladder" pattern representing fragmentation of DNA into oligonucleosome length fragments was observed after 6 h of staurosporine treatment and sustained until 24 h. The Bax expression increased significantly at 6 h after exposure to staurosporine, peaked at 12 h compared with vehicle cultures, and decreased at 24 h. The Bcl-2 expression increased and reached the highest level at 3 h. It was then decreased gradually but still higher than normal expression level.	Staurosporine	117-130	B cell leukemia/lymphoma 2	Mus musculus	324-329
12852832-6	2003	A "ladder" pattern representing fragmentation of DNA into oligonucleosome length fragments was observed after 6 h of staurosporine treatment and sustained until 24 h. The Bax expression increased significantly at 6 h after exposure to staurosporine, peaked at 12 h compared with vehicle cultures, and decreased at 24 h. The Bcl-2 expression increased and reached the highest level at 3 h. It was then decreased gradually but still higher than normal expression level.	Staurosporine	235-248	BCL2-associated X protein	Mus musculus	171-174
12852832-6	2003	A "ladder" pattern representing fragmentation of DNA into oligonucleosome length fragments was observed after 6 h of staurosporine treatment and sustained until 24 h. The Bax expression increased significantly at 6 h after exposure to staurosporine, peaked at 12 h compared with vehicle cultures, and decreased at 24 h. The Bcl-2 expression increased and reached the highest level at 3 h. It was then decreased gradually but still higher than normal expression level.	Staurosporine	235-248	B cell leukemia/lymphoma 2	Mus musculus	324-329
12852832-7	2003	There was an obvious caspase-3 cleavage at 6 h after exposing the cells to staurosporine.	Staurosporine	75-88	caspase 3	Mus musculus	21-30
12852832-8	2003	Treatment with staurosporine for 12 h markedly decreased the expression of p53 protein.	Staurosporine	15-28	transformation related protein 53, pseudogene	Mus musculus	75-78
12852832-9	2003	Cdk5 protein expression did not have obvious changes after the cells were exposed to staurosporine.	Staurosporine	85-98	cyclin-dependent kinase 5	Mus musculus	0-4
12861049-7	2003	In the presence of LLnL, stable phosphorylation of IL-10E1 and induction of TIMP-1 was abrogated if the tyrosine kinase inhibitor, staurosporine, was added.	Staurosporine	131-144	TIMP metallopeptidase inhibitor 1	Homo sapiens	76-82
12808108-4	2003	In vitro, Bax-deficient GBM (BdGBM) exhibited an important resistance to various apoptogenic stimuli (e.g., UV, staurosporine, and doxorubicin) compared to the Bax-expressing GBM (BeGBM).	Staurosporine	112-125	BCL2 associated X, apoptosis regulator	Homo sapiens	10-13
12683950-0	2003	Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor.	Staurosporine	14-27	coagulation factor II thrombin receptor	Homo sapiens	99-128
12683950-0	2003	Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor.	Staurosporine	14-27	protein C receptor	Homo sapiens	133-168
14681028-0	2003	A potential role for cx43-hemichannels in staurosporin-induced apoptosis.	Staurosporine	42-54	gap junction protein alpha 1	Homo sapiens	21-25
12861049-8	2003	The effect of staurosporine on IL-10E1 phosphorylation and TIMP-1 could be overcome if the phosphatase inhibitor, vanadate, was also added, suggesting that phosphorylated IL-10E1 could be stabilized by phosphatase, but not by proteasome inhibition.	Staurosporine	14-27	TIMP metallopeptidase inhibitor 1	Homo sapiens	59-65
12788225-3	2003	PMA-induced galectin-3 overexpression was blocked by: protein kinase C inhibitors staurosporine, calphostin C, and apigenin; tyrosine-specific protein kinase inhibitors genistein and tyrphostin A25; PD 98059, a selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1 (MEK1 or MKK1); and SB 203580, a specific inhibitor of p38 MAPK.	Staurosporine	82-95	galectin 3	Homo sapiens	12-22
12883037-6	2003	The MEK-specific inhibitor U0126 or PKC inhibitor staurosporine (STP) also down-regulated XIAP expression and induced apoptosis.	Staurosporine	50-63	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
12883037-6	2003	The MEK-specific inhibitor U0126 or PKC inhibitor staurosporine (STP) also down-regulated XIAP expression and induced apoptosis.	Staurosporine	50-63	X-linked inhibitor of apoptosis	Homo sapiens	90-94
12883037-6	2003	The MEK-specific inhibitor U0126 or PKC inhibitor staurosporine (STP) also down-regulated XIAP expression and induced apoptosis.	Staurosporine	65-68	mitogen-activated protein kinase kinase 7	Homo sapiens	4-7
12883037-6	2003	The MEK-specific inhibitor U0126 or PKC inhibitor staurosporine (STP) also down-regulated XIAP expression and induced apoptosis.	Staurosporine	65-68	X-linked inhibitor of apoptosis	Homo sapiens	90-94
12702731-5	2003	While staurosporine, H7, etoposide, and chelerythrine released cytochrome c from mitochondria in intact cells, only chelerythrine released cytochrome c from isolated mitochondria.	Staurosporine	6-19	cytochrome c, somatic	Homo sapiens	63-75
12832499-4	2003	Importantly, neurons deficient in functional Kv2.1-encoded K+ channels were protected from oxidant and staurosporine-induced apoptosis.	Staurosporine	103-116	potassium voltage-gated channel subfamily B member 1	Homo sapiens	45-50
12749884-4	2003	A comparison of the PKC isozyme and kinase activity of the series is made to the kinase inhibitor staurosporine.	Staurosporine	98-111	protein kinase C beta	Homo sapiens	20-23
12794824-4	2003	Apoptosis was induced by sodium nitroprusside (SNP) dihydrate, which generates NO, or by staurosporine, which is a proapoptotic agent dependent upon Bax or Bak protein.	Staurosporine	89-102	apoptosis regulator BAX	Oryctolagus cuniculus	149-152
12759177-6	2003	Three PKC inhibitors (staurosporine, calphostin C, and chelerythrine) did not affect basal EAAT3 activity but significantly inhibited the propofol-enhanced EAAT3 activity.	Staurosporine	22-35	solute carrier family 1 member 1	Rattus norvegicus	156-161
12788823-9	2003	(6) In addition, the protein kinase C inhibitor staurosporine significantly attenuated, in a dose-dependent manner, the VEGF-stimulated HO-1 induction observed in CAMs.	Staurosporine	48-61	vascular endothelial growth factor A	Gallus gallus	120-124
12788823-9	2003	(6) In addition, the protein kinase C inhibitor staurosporine significantly attenuated, in a dose-dependent manner, the VEGF-stimulated HO-1 induction observed in CAMs.	Staurosporine	48-61	heme oxygenase 1	Gallus gallus	136-140
12764618-4	2003	Using cleavage site-directed antibodies, specific intracellular detection for cleaved fragments of caspase-8 and -9 was accomplished during apoptosis induced by staurosporine and etoposide.	Staurosporine	161-174	caspase 8	Homo sapiens	99-115
12768189-6	2003	Staurosporine-induced apoptosis was inhibited in the bcl-2-overproducing clones as well as in the parental cell line.	Staurosporine	0-13	BCL2 apoptosis regulator	Homo sapiens	53-58
12755708-8	2003	PDGF-dependent phosphorylation of smap8 was induced prior to ERK1/2 activation, and was repressed by staurosporine, a general inhibitor of serine/threonine kinases.	Staurosporine	101-114	NDRG family member 4	Rattus norvegicus	34-39
12761037-9	2003	C621 synphilin-1 transfected cells were more susceptible to staurosporine-induced cell death than cells expressing wt synphilin-1.	Staurosporine	60-73	synuclein alpha interacting protein	Homo sapiens	5-16
12830052-4	2003	Staurosporine was used as a positive control to induce cytochrome c release through mitochondrial permeability transition-dependent pores, whereas cyclosporine (INN: ciclosporin) was used to specifically inhibit these mitochondrial permeability transition-dependent pores.	Staurosporine	0-13	cytochrome c, somatic	Homo sapiens	55-67
12753305-12	2003	Staurosporine and nifedipine diminished effects of AVP in a nonadditive manner, and attenuated additively the fast component of U-46619 response.	Staurosporine	0-13	arginine vasopressin	Rattus norvegicus	51-54
12764093-6	2003	In contrast, the later mGluR1 currents were either unaffected or enhanced by the protein tyrosine kinase (PTK) inhibitors PP1, K252a, and staurosporine were diminished or blocked by phosphatase inhibitors but were unaffected by inhibitors of serine-threonine kinases PKA, PKC, or PKG.	Staurosporine	138-151	glutamate metabotropic receptor 1	Rattus norvegicus	23-29
12791252-2	2003	We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41-364, in complex with staurosporine at 2.7 A and with ADP at 3.2 A, revealing overall structural similarity with other Ser/Thr kinases.	Staurosporine	140-153	MAPK activated protein kinase 2	Homo sapiens	102-105
12594210-9	2003	The protein kinase C inhibitor staurosporine prevented phosphorylation and internalization of the receptors by CXCR1 activation.	Staurosporine	31-44	C-X-C motif chemokine receptor 1	Homo sapiens	111-116
12719444-7	2003	Staurosporine and wortmannin significantly attenuated suppression of the ANP release and an increase in intra-atrial pressure by LPC.	Staurosporine	0-13	natriuretic peptide A	Rattus norvegicus	73-76
12657723-5	2003	Molecular dynamics and docking simulations, targeting the ATP binding site of aurora2 with adenylyl imidodiphosphate (AMP-PNP), staurosporine, and six small molecular S/T kinase inhibitors, identified active-site residues that interact with these inhibitors differentially.	Staurosporine	128-141	aurora kinase A	Homo sapiens	78-85
12694725-8	2003	None of the inhibitors inhibited Wee1, but both staurosporine and K-252a inhibited Myt1, with IC(50) values of 9.2+/-3.6 and 4.0+/-1.3 microM, respectively.	Staurosporine	48-61	myelin transcription factor 1	Homo sapiens	83-87
12707358-2	2003	A protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or a Src kinase inhibitor (PP2) attenuated TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity.	Staurosporine	36-49	tumor necrosis factor	Homo sapiens	152-161
12547651-5	2003	In contrast, treatment with pro-apoptosis agent staurosporine (STS) induced both cytochrome c release and caspase-3 activation after 2h.	Staurosporine	48-61	cytochrome c, somatic	Homo sapiens	81-93
12547651-5	2003	In contrast, treatment with pro-apoptosis agent staurosporine (STS) induced both cytochrome c release and caspase-3 activation after 2h.	Staurosporine	48-61	caspase 3	Homo sapiens	106-115
12547651-5	2003	In contrast, treatment with pro-apoptosis agent staurosporine (STS) induced both cytochrome c release and caspase-3 activation after 2h.	Staurosporine	63-66	cytochrome c, somatic	Homo sapiens	81-93
12547651-5	2003	In contrast, treatment with pro-apoptosis agent staurosporine (STS) induced both cytochrome c release and caspase-3 activation after 2h.	Staurosporine	63-66	caspase 3	Homo sapiens	106-115
12739161-5	2003	Methyl-2,5-dihydroxycinnamate (DHC), a PTK inhibitor, was more selective for Syk than Lyn, while staurosporine (ST), a broad-specificity protein kinase inhibitor, inhibited Lyn more than Syk.	Staurosporine	97-110	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	173-176
12672549-3	2003	We resolve this discrepancy by using a well-characterised cell system to demonstrate that wild type alpha-synuclein can enhance cell death in response to ischaemia/reoxygenation or staurosporine treatment whilst protecting against serum removal and dopamine-induced cell death.	Staurosporine	181-194	synuclein alpha	Homo sapiens	100-115
12560323-4	2003	Pre-incubation of human kidney epithelial cells (HKC) with TGF-beta1 markedly promoted staurosporine-induced cell death in a time- and dose-dependent manner.	Staurosporine	87-100	transforming growth factor beta 1	Homo sapiens	59-68
12453872-4	2003	Staurosporine- and hypertonic NaCl-induced RTC apoptosis was associated with cell shrinkage and diminished cytosolic pH, and apoptosis was potentiated by amiloride analogs, suggesting NHE1 activity opposes apoptosis.	Staurosporine	0-13	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	184-188
12453872-7	2003	Recombinant caspase-3 cleaved the in vitro-translated NHE1 cytoplasmic domain into five distinct peptides, identical in molecular weight to NHE1 degradation products derived from staurosporine-stimulated RTC lysates.	Staurosporine	179-192	caspase 3	Mus musculus	12-21
12453872-7	2003	Recombinant caspase-3 cleaved the in vitro-translated NHE1 cytoplasmic domain into five distinct peptides, identical in molecular weight to NHE1 degradation products derived from staurosporine-stimulated RTC lysates.	Staurosporine	179-192	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	54-58
12453872-7	2003	Recombinant caspase-3 cleaved the in vitro-translated NHE1 cytoplasmic domain into five distinct peptides, identical in molecular weight to NHE1 degradation products derived from staurosporine-stimulated RTC lysates.	Staurosporine	179-192	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	140-144
12765533-5	2003	PKC inhibition by staurosporine (10 and 100 nM) had no effect on either basal or IFNgamma-induced expression of WRS in either cell line.	Staurosporine	18-31	proline rich transmembrane protein 2	Homo sapiens	0-3
12721754-0	2003	Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell line.	Staurosporine	0-13	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53
12721754-0	2003	Staurosporine-induced apoptosis is independent of p16 and p21 and achieved via arrest at G2/M and at G1 in U251MG human glioma cell line.	Staurosporine	0-13	H3 histone pseudogene 16	Homo sapiens	58-61
12721754-3	2003	METHODS: In the present study an adenovirus vector expressing p16 or p21 genes in human glioma cell lines was used to examine cell cycle regulation and cell death induced by staurosporine.	Staurosporine	174-187	cyclin dependent kinase inhibitor 2A	Homo sapiens	62-65
12721754-3	2003	METHODS: In the present study an adenovirus vector expressing p16 or p21 genes in human glioma cell lines was used to examine cell cycle regulation and cell death induced by staurosporine.	Staurosporine	174-187	H3 histone pseudogene 16	Homo sapiens	69-72
12721754-4	2003	RESULTS: A low concentration (&lt;/=10 n M) of staurosporine induced G1 arrest of U251MG cells, whereas a high concentration (&gt;/=30 n M) induced G2/M arrest and finally induced apoptosis via a caspase-3-activated pathway from both the G2/M and G1 phases.	Staurosporine	47-60	caspase 3	Homo sapiens	196-205
12721754-5	2003	However, pRb was dephosphorylated and cdc2 was inhibited at both the low and the high concentrations of staurosporine, indicating that the mechanisms of cell cycle regulation are not simply p53-Rb- or cdc2-dependent pathways.	Staurosporine	104-117	RB transcriptional corepressor 1	Homo sapiens	9-12
12721754-5	2003	However, pRb was dephosphorylated and cdc2 was inhibited at both the low and the high concentrations of staurosporine, indicating that the mechanisms of cell cycle regulation are not simply p53-Rb- or cdc2-dependent pathways.	Staurosporine	104-117	cyclin dependent kinase 1	Homo sapiens	38-42
12741473-6	2003	Staurosporine decreased proliferation by 86% and completely prevented alpha-smooth muscle actin expression.	Staurosporine	0-13	actin gamma 2, smooth muscle	Rattus norvegicus	70-95
12752372-3	2003	Here we report increased mineralocorticoid receptor expression in rat hippocampal and cortical neurons exposed in vitro to low levels of staurosporine and in rat hippocampal pyramidal neurons exposed in vivo to hypothermic transient global ischaemia.	Staurosporine	137-150	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	25-51
12594176-4	2003	Here, we show that overexpression of wild-type human TERT in HeLa cells, and in a cells lacking TERT but containing the telomerase RNA template, increases their resistance to apoptosis induced by the DNA damaging agent etoposide or the bacterial alkaloid staurosporine.	Staurosporine	255-268	telomerase reverse transcriptase	Homo sapiens	53-57
12645080-3	2003	Treatment of [(3)H]palmitate-labeled cells with staurosporine (to activate caspase 8 and induce apoptosis) or exogenous sphingomyelinase specifically increased the [(3)H]ceramide content of the Raft fraction.	Staurosporine	48-61	caspase 8	Homo sapiens	75-84
12652309-7	2003	BIP inhibited Bax-mediated apoptosis induced by staurosporine, UVC irradiation and anti-cancer drugs in several types of cells.	Staurosporine	48-61	BCL2 associated X, apoptosis regulator	Homo sapiens	14-17
12514174-2	2003	Bovine testicular hyaluronidase PH-20 activates JNK1 and protects L929 fibroblasts from staurosporine-mediated cell death.	Staurosporine	88-101	hyaluronidase PH-20	Bos taurus	18-37
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Staurosporine	143-156	tumor necrosis factor	Homo sapiens	0-9
12645577-2	2003	TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2).	Staurosporine	143-156	intercellular adhesion molecule 1	Homo sapiens	65-71
12556355-7	2003	Staurosporine (10(-9) M), a PKC inhibitor, blocked phorbol 12,13-dibutyrate-induced PKC activity and cell proliferation.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	28-31
12556355-7	2003	Staurosporine (10(-9) M), a PKC inhibitor, blocked phorbol 12,13-dibutyrate-induced PKC activity and cell proliferation.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	84-87
12556355-8	2003	Inhibition of PKC by staurosporine also counteracted the stimulatory effect of CT, CGRP, and amylin on hOB proliferation.	Staurosporine	21-34	proline rich transmembrane protein 2	Homo sapiens	14-17
12556355-8	2003	Inhibition of PKC by staurosporine also counteracted the stimulatory effect of CT, CGRP, and amylin on hOB proliferation.	Staurosporine	21-34	calcitonin related polypeptide alpha	Homo sapiens	83-87
12556355-8	2003	Inhibition of PKC by staurosporine also counteracted the stimulatory effect of CT, CGRP, and amylin on hOB proliferation.	Staurosporine	21-34	islet amyloid polypeptide	Homo sapiens	93-99
12598452-13	2003	Caspase-3 activity was detected as early as 3 hours after exposure with staurosporine, peaking at 12 hours of incubation.	Staurosporine	72-85	caspase 3	Homo sapiens	0-9
12598452-17	2003	Staurosporine induced apoptosis of endothelial cells involves activation of caspase-3, and could be a useful model to study strategies of cell death inhibition.	Staurosporine	0-13	caspase 3	Homo sapiens	76-85
12600435-4	2003	The effect of PRL on TRAIL-, staurosporine- and flavopiridol-induced apoptosis was assessed by Timelapse microscopy and Annexin V binding.	Staurosporine	29-42	prolactin	Homo sapiens	14-17
12603329-2	2003	In addition, the treatment of PDE5A1-transfected Cos-7 and PC12 cells with staurosporine, an apoptotic agent that activates endogenous caspase-3, also induced proteolysis and inactivation of PDE5A1.	Staurosporine	75-88	caspase 3	Rattus norvegicus	135-144
12603826-3	2003	Staurosporine, used as a positive control for apoptosis, caused Poly(ADP-ribose)-polymerase (PARP) cleavage and nuclear fragmentation, but no PARP cleavage and little fragmentation were seen after OGD.	Staurosporine	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	64-91
12603826-3	2003	Staurosporine, used as a positive control for apoptosis, caused Poly(ADP-ribose)-polymerase (PARP) cleavage and nuclear fragmentation, but no PARP cleavage and little fragmentation were seen after OGD.	Staurosporine	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	93-97
12914753-8	2003	The down-regulation of CXCR6 expression induced by CD3/CD28 activation was blocked by the broad kinase inhibitor, staurosporine, and by the src kinase inhibitor, PP2, but not by the MEK1 inhibitor, U0106.	Staurosporine	114-127	C-X-C motif chemokine receptor 6	Homo sapiens	23-28
12914753-8	2003	The down-regulation of CXCR6 expression induced by CD3/CD28 activation was blocked by the broad kinase inhibitor, staurosporine, and by the src kinase inhibitor, PP2, but not by the MEK1 inhibitor, U0106.	Staurosporine	114-127	CD28 molecule	Homo sapiens	55-59
12576481-4	2003	Wild type and calpastatin overexpressing (CST1) cells were neuronally differentiated and apoptosis-induced with staurosporine (0.1-1.0 microm).	Staurosporine	112-125	cystatin SN	Homo sapiens	42-46
12576481-6	2003	Following 0.1-0.2 microm staurosporine, plasma membrane integrity based on calcein-acetoxymethyl fluorescence was significantly greater at 24 h in differentiated CST1 compared with differentiated wild type cells.	Staurosporine	25-38	cystatin SN	Homo sapiens	162-166
12668244-5	2003	These results demonstrated that HupA protect neurons against staurosporine-induced apoptosis via regulating the apoptotic related genes and caspase-3 proenzyme.	Staurosporine	61-74	caspase 3	Rattus norvegicus	140-149
12556443-0	2003	The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.	Staurosporine	62-75	presenilin 2	Homo sapiens	27-39
12556443-0	2003	The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.	Staurosporine	62-75	tumor protein p53	Homo sapiens	49-52
12556443-3	2003	We show first that overexpression of the presenilinase-derived maturation product of presenilin 2 (CTF-PS2) increases Abeta recovery, the production of which is almost abolished by a caspase 3 inhibitor and increased by staurosporine.	Staurosporine	220-233	presenilin 2	Homo sapiens	85-97
12657723-6	2003	The docked structures of the aurora2-AMP-PNP and aurora2-staurosporine complexes indicated that the adenine ring of AMP-PNP and the indolocarbazole moiety of staurosporine have similar positions and orientations and provided the basis for the docking of the other S/T kinase inhibitors.	Staurosporine	158-171	aurora kinase A	Homo sapiens	29-36
12657723-6	2003	The docked structures of the aurora2-AMP-PNP and aurora2-staurosporine complexes indicated that the adenine ring of AMP-PNP and the indolocarbazole moiety of staurosporine have similar positions and orientations and provided the basis for the docking of the other S/T kinase inhibitors.	Staurosporine	158-171	aurora kinase A	Homo sapiens	49-56
12657723-7	2003	Inhibitors with isoquinoline and quinazoline moieties were recognized by aurora2 in which H-89 and 6,7-dimethoxyquinazoline compounds exhibited high binding energies compared with that of staurosporine.	Staurosporine	188-201	aurora kinase A	Homo sapiens	73-80
12657723-9	2003	The aurora2 structural model provides a rational basis for site-directed mutagenesis of the active site; design of novel H-89, staurosporine, and quinazoline analogues; and the screening of the available chemical database for the identification of other novel, small-molecular entities.	Staurosporine	127-140	aurora kinase A	Homo sapiens	4-11
12691733-7	2003	In neuroblastoma cells, RING-deleted XIAP protected against death induced by staurosporine, thapsigargin, or serum withdrawal, whereas full-length XIAP was without effect.	Staurosporine	77-90	X-linked inhibitor of apoptosis	Mus musculus	37-41
12486121-7	2003	This agrin-induced increase in rapsyn-AChR interaction strongly correlates with clustering, because staurosporine and herbimycin blocked both the increase and clustering.	Staurosporine	100-113	agrin	Homo sapiens	5-10
12486121-7	2003	This agrin-induced increase in rapsyn-AChR interaction strongly correlates with clustering, because staurosporine and herbimycin blocked both the increase and clustering.	Staurosporine	100-113	receptor associated protein of the synapse	Homo sapiens	31-37
12482880-6	2003	Although PCA inhibited the enzymatic activities of active recombinant caspase-3, caspase-8, and caspase-9 at similar concentrations, PCA exerted weak inhibitory effects on activation of caspase-9 and caspase-3 in staurosporine-treated cells but strongly inhibited caspase-8 activation in FasL-treated cells.	Staurosporine	213-226	caspase 3	Homo sapiens	70-79
12581734-0	2003	Staurosporine-induced death of MCF-7 human breast cancer cells: a distinction between caspase-3-dependent steps of apoptosis and the critical lethal lesions.	Staurosporine	0-13	caspase 3	Homo sapiens	86-95
12581734-2	2003	Cells were exposed to increasing doses (0.15-1 microM) of staurosporine for periods up to 19 h. Apoptosis was efficiently induced in MCF-7c3 cells, as demonstrated by cytochrome c release, processing of procaspase-3, procaspase-8, and Bid, increase in caspase-3-like DEVDase activity, cleavage of the enzyme poly(ADP-ribose) polymerase, DNA fragmentation, changes in nuclear morphology, and TUNEL assay and flow cytometry.	Staurosporine	58-71	cytochrome c, somatic	Homo sapiens	167-179
12581734-2	2003	Cells were exposed to increasing doses (0.15-1 microM) of staurosporine for periods up to 19 h. Apoptosis was efficiently induced in MCF-7c3 cells, as demonstrated by cytochrome c release, processing of procaspase-3, procaspase-8, and Bid, increase in caspase-3-like DEVDase activity, cleavage of the enzyme poly(ADP-ribose) polymerase, DNA fragmentation, changes in nuclear morphology, and TUNEL assay and flow cytometry.	Staurosporine	58-71	caspase 3	Homo sapiens	203-215
12581734-2	2003	Cells were exposed to increasing doses (0.15-1 microM) of staurosporine for periods up to 19 h. Apoptosis was efficiently induced in MCF-7c3 cells, as demonstrated by cytochrome c release, processing of procaspase-3, procaspase-8, and Bid, increase in caspase-3-like DEVDase activity, cleavage of the enzyme poly(ADP-ribose) polymerase, DNA fragmentation, changes in nuclear morphology, and TUNEL assay and flow cytometry.	Staurosporine	58-71	BH3 interacting domain death agonist	Homo sapiens	235-238
12581734-2	2003	Cells were exposed to increasing doses (0.15-1 microM) of staurosporine for periods up to 19 h. Apoptosis was efficiently induced in MCF-7c3 cells, as demonstrated by cytochrome c release, processing of procaspase-3, procaspase-8, and Bid, increase in caspase-3-like DEVDase activity, cleavage of the enzyme poly(ADP-ribose) polymerase, DNA fragmentation, changes in nuclear morphology, and TUNEL assay and flow cytometry.	Staurosporine	58-71	caspase 3	Homo sapiens	206-215
12581734-2	2003	Cells were exposed to increasing doses (0.15-1 microM) of staurosporine for periods up to 19 h. Apoptosis was efficiently induced in MCF-7c3 cells, as demonstrated by cytochrome c release, processing of procaspase-3, procaspase-8, and Bid, increase in caspase-3-like DEVDase activity, cleavage of the enzyme poly(ADP-ribose) polymerase, DNA fragmentation, changes in nuclear morphology, and TUNEL assay and flow cytometry.	Staurosporine	58-71	poly(ADP-ribose) polymerase 1	Homo sapiens	308-335
12581734-3	2003	For all of these measures except cytochrome c release, little or no activity was detected in MCF-7v cells, confirming that caspase-3 is essential for efficient induction of apoptosis by staurosporine, but not for mitochondrial steps that occur earlier in the pathway.	Staurosporine	186-199	caspase 3	Homo sapiens	123-132
12536203-4	2003	Down-regulation of cathepsin L by antisense cDNA significantly impaired (up to 70%) glioma cell invasion in vitro and markedly increased glioma cell apoptosis induced by staurosporine.	Staurosporine	170-183	cathepsin L	Homo sapiens	19-30
12657723-6	2003	The docked structures of the aurora2-AMP-PNP and aurora2-staurosporine complexes indicated that the adenine ring of AMP-PNP and the indolocarbazole moiety of staurosporine have similar positions and orientations and provided the basis for the docking of the other S/T kinase inhibitors.	Staurosporine	57-70	aurora kinase A	Homo sapiens	29-36
12657723-6	2003	The docked structures of the aurora2-AMP-PNP and aurora2-staurosporine complexes indicated that the adenine ring of AMP-PNP and the indolocarbazole moiety of staurosporine have similar positions and orientations and provided the basis for the docking of the other S/T kinase inhibitors.	Staurosporine	57-70	aurora kinase A	Homo sapiens	49-56
12562334-8	2003	However, treatment with protein kinase C (PKC) inhibitors, such as GF109203X and staurosporine, resulted in a striking inhibition of eosinophil shape change by IL-5, but not eotaxin.	Staurosporine	81-94	proline rich transmembrane protein 2	Homo sapiens	24-40
12562334-8	2003	However, treatment with protein kinase C (PKC) inhibitors, such as GF109203X and staurosporine, resulted in a striking inhibition of eosinophil shape change by IL-5, but not eotaxin.	Staurosporine	81-94	proline rich transmembrane protein 2	Homo sapiens	42-45
12562334-8	2003	However, treatment with protein kinase C (PKC) inhibitors, such as GF109203X and staurosporine, resulted in a striking inhibition of eosinophil shape change by IL-5, but not eotaxin.	Staurosporine	81-94	interleukin 5	Homo sapiens	160-164
12588890-9	2003	Albumin-induced ROS generation, NF-kappaB activation, and IL-8 secretion were endocytosis- and PKC-dependent as these downstream events were abrogated by the PI3K inhibitors LY294002 and wortmannin, and the PKC inhibitors GF109203X and staurosporin, respectively.	Staurosporine	236-248	albumin	Homo sapiens	0-7
12542519-5	2003	Staurosporine, a potent inhibitor of phospholipid Ca2+-dependent protein kinase, increased externalized phosphatidylserine levels on SZ95 sebocytes, detected by annexin V/propidium iodide flow cytometry, as early as after 1 h, whereas dose-dependent reduction of bcl-2 mRNA and protein expression, enhanced DNA fragmentation, and increased caspase 3 levels, detected by caspase 3 inhibitor/propidium iodide flow cytometry, were found after 6 h of treatment.	Staurosporine	0-13	annexin A5	Homo sapiens	161-170
12542519-5	2003	Staurosporine, a potent inhibitor of phospholipid Ca2+-dependent protein kinase, increased externalized phosphatidylserine levels on SZ95 sebocytes, detected by annexin V/propidium iodide flow cytometry, as early as after 1 h, whereas dose-dependent reduction of bcl-2 mRNA and protein expression, enhanced DNA fragmentation, and increased caspase 3 levels, detected by caspase 3 inhibitor/propidium iodide flow cytometry, were found after 6 h of treatment.	Staurosporine	0-13	BCL2 apoptosis regulator	Homo sapiens	263-268
12542519-5	2003	Staurosporine, a potent inhibitor of phospholipid Ca2+-dependent protein kinase, increased externalized phosphatidylserine levels on SZ95 sebocytes, detected by annexin V/propidium iodide flow cytometry, as early as after 1 h, whereas dose-dependent reduction of bcl-2 mRNA and protein expression, enhanced DNA fragmentation, and increased caspase 3 levels, detected by caspase 3 inhibitor/propidium iodide flow cytometry, were found after 6 h of treatment.	Staurosporine	0-13	caspase 3	Homo sapiens	340-349
12542519-5	2003	Staurosporine, a potent inhibitor of phospholipid Ca2+-dependent protein kinase, increased externalized phosphatidylserine levels on SZ95 sebocytes, detected by annexin V/propidium iodide flow cytometry, as early as after 1 h, whereas dose-dependent reduction of bcl-2 mRNA and protein expression, enhanced DNA fragmentation, and increased caspase 3 levels, detected by caspase 3 inhibitor/propidium iodide flow cytometry, were found after 6 h of treatment.	Staurosporine	0-13	caspase 3	Homo sapiens	370-379
12526027-0	2003	Caspase activation pathways induced by staurosporine and low potassium: role of caspase-2.	Staurosporine	39-52	caspase 2	Homo sapiens	0-7
12527732-8	2003	Na(+)-K(+)ATPase activity modulation was dependent on PKC activation since the PKC antagonist staurosporine abolished the stimulatory effect of Ang II.	Staurosporine	94-107	angiotensinogen	Rattus norvegicus	144-150
12565805-5	2003	Moreover, the ability of human lens epithelial cells in culture to respond to the apoptosis-inducing agent staurosporin by activation of caspase-3 was investigated.	Staurosporine	107-119	caspase 3	Homo sapiens	137-146
12555061-5	2003	The basal activation of NF-kappaB in cells expressing H-Ras impaired staurosporine-induced apoptosis in these cells, through a mechanism that was NF-kappaB-dependent and inhibitable in the presence of z-VAD.	Staurosporine	69-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	24-33
12555061-5	2003	The basal activation of NF-kappaB in cells expressing H-Ras impaired staurosporine-induced apoptosis in these cells, through a mechanism that was NF-kappaB-dependent and inhibitable in the presence of z-VAD.	Staurosporine	69-82	Harvey rat sarcoma virus oncogene	Mus musculus	54-59
12555061-5	2003	The basal activation of NF-kappaB in cells expressing H-Ras impaired staurosporine-induced apoptosis in these cells, through a mechanism that was NF-kappaB-dependent and inhibitable in the presence of z-VAD.	Staurosporine	69-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	146-155
12555061-6	2003	Moreover, titration of caspase activation in response to staurosporine showed a significant resistance in cells expressing H-Ras when compared with the void vector or the N-Ras counterparts.	Staurosporine	57-70	Harvey rat sarcoma virus oncogene	Mus musculus	123-128
12555061-6	2003	Moreover, titration of caspase activation in response to staurosporine showed a significant resistance in cells expressing H-Ras when compared with the void vector or the N-Ras counterparts.	Staurosporine	57-70	neuroblastoma ras oncogene	Mus musculus	171-176
12503085-6	2003	The CNTF-ST14A cells displayed improved stress response compared with native ST14A cells under differentiation conditions, i.e., at the nonpermissive temperature of 39 degrees C and after staurosporine exposure, respectively.	Staurosporine	188-201	ciliary neurotrophic factor	Rattus norvegicus	4-8
12566854-7	2003	Indomethacin, H-89, staurosporine and genistein inhibit acid-induced DBS, indicating involvement of the cyclooxygenase, PKA, PKC and TK pathways.	Staurosporine	20-33	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	120-123
12566244-2	2003	We reported previously that staurosporine, cycloheximide, actinomycin D, as well as more physiological apoptotic agents (lactosylceramide, 15d-PGJ(2)) increase prostaglandin release in parallel with induction of apoptosis in WISH and amnion epithelial cells.	Staurosporine	28-41	NCK interacting protein with SH3 domain	Homo sapiens	225-229
12504093-0	2003	Protection of insulin receptor substrate-3 from staurosporine-induced apoptosis.	Staurosporine	48-61	insulin receptor	Homo sapiens	14-30
12403774-2	2003	On the other hand, the activity of cytochrome c oxidase is unchanged for the first 8 h after staurosporine treatment, as determined by oxygen consumption measurements in intact cells.	Staurosporine	93-106	cytochrome c, somatic	Homo sapiens	35-47
12403774-11	2003	Most significantly, Bcl-2 overexpression prevents the staurosporine-induced hypersensitivity of the outer membrane to digitonin.	Staurosporine	54-67	BCL2 apoptosis regulator	Homo sapiens	20-25
17682315-4	2003	In this study, we hypothesize that PGF2alpha and staurosporine will induce apoptosis in the rat corpus luteum and this process is mediated through the mitochondrial phospholipid cardiolipin and activation of caspase-9.	Staurosporine	49-62	caspase 9	Rattus norvegicus	208-217
12451591-6	2003	Both a nonspecific (100 nM staurosporine) and a highly selective antagonist of PKC (200 nM bisindolylmaleimide I) blocked dephosphorylation of cofilin in neutrophils stimulated with PMA but not with fMLP or ionophore A23187.	Staurosporine	27-40	cofilin 1	Homo sapiens	143-150
12488334-3	2003	The ability of C-type natriuretic peptide to suppress evoked dopamine efflux was abolished by treatment with the protein kinase C inhibitors chelerythrine (10 micro M) and staurosporine (10 nM).	Staurosporine	172-185	natriuretic peptide C	Rattus norvegicus	15-41
14965035-4	2003	The similar results were demonstrated in skinned aorta SMC of spontaneously hypertensive rats where an increase in myofilament Ca(2+)-sensitivity was also abolished by PKC inhibitors chelerythrine and staurosporine.	Staurosporine	201-214	protein kinase C, gamma	Rattus norvegicus	168-171
12559002-8	2003	Treatment with high concentrations of the broad-spectrum kinase inhibitor staurosporine prevents LK-mediated CBP hyperphosphorylation and inhibits cell death.	Staurosporine	74-87	CREB binding protein	Homo sapiens	109-112
12490592-4	2003	ATP pretreatment effects on 5-HT 1A agonist responsiveness were blocked by the protein kinase inhibitors staurosporine and bisindolylmaleimide, suggesting that the ATP-mediated temporal regulation involves activation of protein kinase C (PKC).	Staurosporine	105-118	5-hydroxytryptamine receptor 1A	Homo sapiens	28-35
12490620-7	2003	The AQZs inhibit endogenous caspase-3 activity toward a cell permeable, exogenously added substrate in staurosporine-treated SH-SY5Y cells.	Staurosporine	103-116	caspase 3	Homo sapiens	28-37
14610335-6	2003	On the other hand, EGF-induced inhibition of Pi uptake was blocked by staurosporine, H-7, or bisindolylmaleimide I (PKC inhibitors), PD 98059 (a p44/42 MAPK inhibitor), but not by SB 203580 (a p38 MAPK inhibitor).	Staurosporine	70-83	epidermal growth factor	Homo sapiens	19-22
14610327-11	2003	Inhibitors of protein kinase C (PKC), Ro-31-8220 and staurosporin, significantly suppressed TGF-beta1-induced VEGF protein expression.	Staurosporine	53-65	transforming growth factor, beta 1	Mus musculus	92-101
14610327-11	2003	Inhibitors of protein kinase C (PKC), Ro-31-8220 and staurosporin, significantly suppressed TGF-beta1-induced VEGF protein expression.	Staurosporine	53-65	vascular endothelial growth factor A	Mus musculus	110-114
12605888-7	2003	We also examined the susceptibility of the PS2-transfected cells to apoptosis induced by the apoptotic inducers staurosporine and H(2)O(2).	Staurosporine	112-125	presenilin 2	Homo sapiens	43-46
12703402-7	2003	LysoPC-induced MCP-1 mRNA expression in GEC was suppressed by genistein and staurosporine.	Staurosporine	76-89	C-C motif chemokine 2	Bos taurus	15-20
12397073-3	2002	We show that alpha-synuclein drastically lowers basal and staurosporine-stimulated caspase 3 immunoreactivity and activity.	Staurosporine	58-71	synuclein, alpha	Mus musculus	13-28
12397073-3	2002	We show that alpha-synuclein drastically lowers basal and staurosporine-stimulated caspase 3 immunoreactivity and activity.	Staurosporine	58-71	caspase 3	Mus musculus	83-92
12393866-0	2002	Regulation of intracellular pH mediates Bax activation in HeLa cells treated with staurosporine or tumor necrosis factor-alpha.	Staurosporine	82-95	BCL2 associated X, apoptosis regulator	Homo sapiens	40-43
12393866-13	2002	It is concluded that with either staurosporine or TNF a furosemide-sensitive change in pH(i) is linked to Bax translocation, cytochrome c release, and cell killing.	Staurosporine	33-46	BCL2 associated X, apoptosis regulator	Homo sapiens	106-109
12393866-13	2002	It is concluded that with either staurosporine or TNF a furosemide-sensitive change in pH(i) is linked to Bax translocation, cytochrome c release, and cell killing.	Staurosporine	33-46	cytochrome c, somatic	Homo sapiens	125-137
12459177-6	2002	Staurosporine only moderately decreased the prolongation of nuclear phosphorylated STAT1 after pretreatment with pervanadate or lactacystin.	Staurosporine	0-13	signal transducer and activator of transcription 1	Homo sapiens	83-88
12443983-0	2002	Citicoline increases glutathione redox ratio and reduces caspase-3 activation and cell death in staurosporine-treated SH-SY5Y human neuroblastoma cells.	Staurosporine	96-109	caspase 3	Homo sapiens	57-66
12443983-6	2002	Finally, citicoline also reduces the expression levels of active caspase-3 and specific PARP-cleaved products of 89 kDa resulting from staurosporine exposure when citicoline is added to the culture medium 24 h before staurosporine.	Staurosporine	135-148	poly(ADP-ribose) polymerase 1	Homo sapiens	88-92
12443983-6	2002	Finally, citicoline also reduces the expression levels of active caspase-3 and specific PARP-cleaved products of 89 kDa resulting from staurosporine exposure when citicoline is added to the culture medium 24 h before staurosporine.	Staurosporine	217-230	poly(ADP-ribose) polymerase 1	Homo sapiens	88-92
12443983-7	2002	These findings demonstrate that citicoline affects the staurosporine-induced apoptosis cell-signalling pathway by interacting with the glutathione system and by inhibiting caspase-3 in SH-SY5Y human neuroblastoma cells.	Staurosporine	55-68	caspase 3	Homo sapiens	172-181
12417624-4	2002	Stable expression of M11L prevents the release of mitochondrial cytochrome c induced by staurosporine or protoporphyrin IX (PPIX), a ligand of the PBR.	Staurosporine	88-101	cytochrome c, somatic	Homo sapiens	64-76
12493856-8	2003	Calmodulin or a Ca(2+)-dependent protein kinase is also implicated in the signal transduction sequence, based on the results obtained with two types of calmodulin antagonists, fluphenazine and N-(-6-amino-hexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and staurosporine, an inhibitor of protein kinases.	Staurosporine	257-270	calmodulin	Nicotiana tabacum	0-10
12493856-8	2003	Calmodulin or a Ca(2+)-dependent protein kinase is also implicated in the signal transduction sequence, based on the results obtained with two types of calmodulin antagonists, fluphenazine and N-(-6-amino-hexyl)-5-chloro-1-naphthalenesulphonamide (W-7) and staurosporine, an inhibitor of protein kinases.	Staurosporine	257-270	calmodulin	Nicotiana tabacum	152-162
14599348-4	2002	In the present study, staurosporine, a potent, nonselective kinase inhibitor, was chemically conjugated to a small fragment of beta-galactosidase (termed ED-SS).	Staurosporine	22-35	galactosidase beta 1	Homo sapiens	127-145
12437592-2	2002	PrPc expression in stably transfected HEK293 human cells did not modify basal apoptotic tonus but drastically potentiated staurosporine-stimulated cellular toxicity and DNA fragmentation as well as caspase 3-like activity and immunoreactivity.	Staurosporine	122-135	prion protein	Homo sapiens	0-4
12437592-3	2002	An identical staurosporine-induced caspase 3 activation was observed after doxycycline in the PrPc-inducible Rov9 cell line.	Staurosporine	13-26	caspase-3	Oryctolagus cuniculus	35-44
12437592-3	2002	An identical staurosporine-induced caspase 3 activation was observed after doxycycline in the PrPc-inducible Rov9 cell line.	Staurosporine	13-26	prion protein	Homo sapiens	94-98
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	Staurosporine	48-61	protein kinase C, alpha	Rattus norvegicus	22-25
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	Staurosporine	48-61	epidermal growth factor like 1	Rattus norvegicus	119-122
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	Staurosporine	48-61	thyrotropin releasing hormone	Rattus norvegicus	127-130
12456804-6	2002	Multiple nonselective PKC inhibitors, including staurosporine, bisindolylmaleimide I, and Calphostin C, inhibited both EGF and TRH induced rat PRL promoter activity.	Staurosporine	48-61	prolactin	Rattus norvegicus	143-146
12364342-5	2002	Here, we show that the time required for Smac efflux from the mitochondria of cells subjected to staurosporine-induced apoptosis is approximately four times longer than the time required for cytochrome c efflux.	Staurosporine	97-110	diablo IAP-binding mitochondrial protein	Homo sapiens	41-45
12444550-3	2002	Staurosporine-induced apoptosis is sensitive to Bcl-2 but insensitive to Cyclosporin A and oligomycin.	Staurosporine	0-13	BCL2 apoptosis regulator	Homo sapiens	48-53
12417306-3	2002	However, soluble myc-hApg5 was degraded during apoptosis induced by staurosporine or TNFalpha/cycloheximide whilst expression of soluble p45ASP was stabilised.	Staurosporine	68-81	autophagy related 5	Homo sapiens	21-26
12414998-7	2002	The broad-range protein kinase inhibitor staurosporine caused a decrease in the nuclear level of cPLA(2)-alpha, whereas the protein phosphatase inhibitor okadaic acid increased the level of nuclear cPLA(2)-alpha.	Staurosporine	41-54	phospholipase A2 group IVA	Homo sapiens	97-110
12244092-4	2002	Chk1 structures with staurosporine and its analog SB-218078 were also determined.	Staurosporine	21-34	checkpoint kinase 1	Homo sapiens	0-4
12417624-6	2002	Myxoma virus infection and the associated expression of early proteins, including M11L, protects cells from staurosporine- and Fas-mediated mitochondrial membrane potential loss and this effect is augmented by the presence of PBR.	Staurosporine	108-121	translocator protein	Homo sapiens	226-229
12480787-3	2002	In the present study, we compared the vulnerability of cultured neurons prepared from APOE-knockout mice upon exposure to glutamate, hydrogen peroxide, and staurosporine.	Staurosporine	156-169	apolipoprotein E	Mus musculus	86-90
12530398-3	2002	The specificity of the response to PKC was confirmed by using staurosporine, chelerythrine or 4-alpha-PMA.	Staurosporine	62-75	protein kinase C, gamma	Rattus norvegicus	35-38
12220617-5	2002	Both DNA synthesis and phosphorylation of MAPK in response to SP were attenuated by pretreatment with pertussis toxin, genistein, D609, U73122, staurosporine, removal of Ca(2+) by BAPTA/AM plus EGTA, PD98059, and SB202190.	Staurosporine	144-157	tachykinin precursor 1	Homo sapiens	62-64
12413889-0	2002	Cell shape change precedes staurosporine-induced stabilization and accumulation of p27kip1.	Staurosporine	27-40	cyclin dependent kinase inhibitor 1B	Homo sapiens	83-90
12413889-2	2002	In the non-small-cell lung carcinoma cell line A549, the kinase inhibitor staurosporine induced G1 cell cycle arrest with an accumulation of the cyclin-dependent kinase inhibitor p27kip1.	Staurosporine	74-87	cyclin dependent kinase inhibitor 1B	Homo sapiens	179-186
12413889-6	2002	The shape change induced by staurosporine preceded the accumulation of p27kip1 by about 4 h. The accumulation of p27kip1 was not due to enhanced transcription but to stabilization of the protein resulting from the inhibition of proteolytic degradation.	Staurosporine	28-41	cyclin dependent kinase inhibitor 1B	Homo sapiens	71-78
12413889-6	2002	The shape change induced by staurosporine preceded the accumulation of p27kip1 by about 4 h. The accumulation of p27kip1 was not due to enhanced transcription but to stabilization of the protein resulting from the inhibition of proteolytic degradation.	Staurosporine	28-41	cyclin dependent kinase inhibitor 1B	Homo sapiens	113-120
12413889-7	2002	Staurosporine, however, did not inhibit directly the proteasome that was involved in the cell-cycle-dependent p27kip1 degradation.	Staurosporine	0-13	cyclin dependent kinase inhibitor 1B	Homo sapiens	110-117
12413889-8	2002	The results indicate that the cell shape change caused by staurosporine correlates with the accumulation of p27kip1 and that staurosporine interferes with the p27kip1-specific proteolysis activity.	Staurosporine	58-71	cyclin dependent kinase inhibitor 1B	Homo sapiens	108-115
12413889-8	2002	The results indicate that the cell shape change caused by staurosporine correlates with the accumulation of p27kip1 and that staurosporine interferes with the p27kip1-specific proteolysis activity.	Staurosporine	125-138	cyclin dependent kinase inhibitor 1B	Homo sapiens	159-166
12491792-0	2002	[Caspase-3-mediated alpha-smooth muscle actin cleavage during staurosporine-induced myofibroblast apoptosis].	Staurosporine	62-75	caspase 3	Rattus norvegicus	1-10
12445185-0	2002	Staurosporine-induced cleavage of alpha-smooth muscle actin during myofibroblast apoptosis.	Staurosporine	0-13	actin gamma 2, smooth muscle	Rattus norvegicus	34-59
12445185-3	2002	Staurosporine (1 microM) activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 (32 kDa) to active forms (17, 19, and 20 kDa).	Staurosporine	0-13	caspase 3	Rattus norvegicus	35-44
12445185-3	2002	Staurosporine (1 microM) activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 (32 kDa) to active forms (17, 19, and 20 kDa).	Staurosporine	0-13	caspase 3	Rattus norvegicus	76-85
12445185-4	2002	Microfilaments mainly composed of alpha-smooth muscle actin, a contractile protein characterizing myofibroblasts, were degraded during staurosporine-induced apoptosis.	Staurosporine	135-148	actin gamma 2, smooth muscle	Rattus norvegicus	34-59
12445185-5	2002	The degradation of alpha-smooth muscle actin bundles was detected as early as 1 h after the treatment with staurosporine.	Staurosporine	107-120	actin gamma 2, smooth muscle	Rattus norvegicus	19-44
12445185-6	2002	Recombinant active caspase-3 and staurosporine-stimulated caspase-3 both cleaved purified alpha-smooth muscle actin in vitro.	Staurosporine	33-46	caspase 3	Rattus norvegicus	58-67
12445185-6	2002	Recombinant active caspase-3 and staurosporine-stimulated caspase-3 both cleaved purified alpha-smooth muscle actin in vitro.	Staurosporine	33-46	actin gamma 2, smooth muscle	Rattus norvegicus	90-115
12495557-1	2002	Staurosporine induced apoptosis of RAW 264.7 cells, a mouse macrophage-like cell line, as determined by DNA fragmentation, the increase of annexin V-stained cells, and the cleavage of poly(ADP-ribose)polymerase (PARP), a substrate of caspase.	Staurosporine	0-13	annexin A5	Mus musculus	139-148
12495557-1	2002	Staurosporine induced apoptosis of RAW 264.7 cells, a mouse macrophage-like cell line, as determined by DNA fragmentation, the increase of annexin V-stained cells, and the cleavage of poly(ADP-ribose)polymerase (PARP), a substrate of caspase.	Staurosporine	0-13	poly (ADP-ribose) polymerase family, member 1	Mus musculus	184-210
12495557-1	2002	Staurosporine induced apoptosis of RAW 264.7 cells, a mouse macrophage-like cell line, as determined by DNA fragmentation, the increase of annexin V-stained cells, and the cleavage of poly(ADP-ribose)polymerase (PARP), a substrate of caspase.	Staurosporine	0-13	poly (ADP-ribose) polymerase family, member 1	Mus musculus	212-216
12495557-3	2002	Staurosporine induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) but suppressed spontaneous phosphorylation of p44/42 MAPK.	Staurosporine	0-13	mitogen-activated protein kinase 3	Mus musculus	79-83
12495557-3	2002	Staurosporine induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) but suppressed spontaneous phosphorylation of p44/42 MAPK.	Staurosporine	0-13	mitogen-activated protein kinase 3	Mus musculus	131-134
12495557-3	2002	Staurosporine induced phosphorylation of p38 mitogen-activated protein kinase (MAPK) but suppressed spontaneous phosphorylation of p44/42 MAPK.	Staurosporine	0-13	mitogen-activated protein kinase 3	Mus musculus	138-142
12495557-4	2002	The p38 MAPK inhibitor SB203580, the MAPK/extracellular signal-regulated kinase kinase inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 potentiated the staurosporine-induced PARP cleavage and DNA fragmentation.	Staurosporine	185-198	mitogen-activated protein kinase 14	Mus musculus	4-12
12495557-4	2002	The p38 MAPK inhibitor SB203580, the MAPK/extracellular signal-regulated kinase kinase inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 potentiated the staurosporine-induced PARP cleavage and DNA fragmentation.	Staurosporine	185-198	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	113-142
12495557-4	2002	The p38 MAPK inhibitor SB203580, the MAPK/extracellular signal-regulated kinase kinase inhibitor PD98059 and the phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 potentiated the staurosporine-induced PARP cleavage and DNA fragmentation.	Staurosporine	185-198	poly (ADP-ribose) polymerase family, member 1	Mus musculus	207-211
12495557-8	2002	The staurosporine-induced apoptosis is positively regulated by PKC, negatively regulated by p38 MAPK, p44/42 MAPK and PI3K via the caspase cascade, and negatively regulated by PKA without regulation of caspase activation.	Staurosporine	4-17	mitogen-activated protein kinase 14	Mus musculus	92-100
12495557-8	2002	The staurosporine-induced apoptosis is positively regulated by PKC, negatively regulated by p38 MAPK, p44/42 MAPK and PI3K via the caspase cascade, and negatively regulated by PKA without regulation of caspase activation.	Staurosporine	4-17	mitogen-activated protein kinase 3	Mus musculus	102-105
12495557-8	2002	The staurosporine-induced apoptosis is positively regulated by PKC, negatively regulated by p38 MAPK, p44/42 MAPK and PI3K via the caspase cascade, and negatively regulated by PKA without regulation of caspase activation.	Staurosporine	4-17	mitogen-activated protein kinase 3	Mus musculus	96-100
12410563-9	2002	In contrast, transfection of cell lines with a plasmid construct to achieve DENN overexpression augmented cellular proliferation and could reverse the apoptotic effect of antisense and staurosporine treatment.	Staurosporine	185-198	MAP kinase activating death domain	Homo sapiens	76-80
12374304-9	2002	Aox1 induction by citrate, but not by antimycin, was prevented by including the protein kinase inhibitor staurosporine in the medium.	Staurosporine	105-118	ubiquinol oxidase 1, mitochondrial	Glycine max	0-4
12398914-5	2002	On the contrary, chelerythrine and staurosporine--blockers of protein kinase C--as well as forskolin, an activator of adenylyl cyclase and a blocker of phosphodiesterase, markedly enhanced the facilitatory effect of angiotensin II and bradykinin.	Staurosporine	35-48	angiotensinogen	Rattus norvegicus	216-230
12373608-4	2002	Staurosporine induced DEVDase activity in T47D cells suggesting the involvement of caspase-3 and/or caspase-7, yet there was no DEVDase activity in MCF-7 cells, probably ruling out the involvement caspase-7.	Staurosporine	0-13	caspase 3	Homo sapiens	83-92
12373608-4	2002	Staurosporine induced DEVDase activity in T47D cells suggesting the involvement of caspase-3 and/or caspase-7, yet there was no DEVDase activity in MCF-7 cells, probably ruling out the involvement caspase-7.	Staurosporine	0-13	caspase 7	Homo sapiens	100-109
12373608-6	2002	Caspase dependent PARP cleavage was detected in MCF-7 cells at 3 h, whereas only partial PARP cleavage was detected in T47D cells and then only after 24 h. Moreover, staurosporine led to cytochrome c release at 2 h in MCF-7 cells and 6 h in T47D cells.	Staurosporine	166-179	poly(ADP-ribose) polymerase 1	Homo sapiens	18-22
12373608-6	2002	Caspase dependent PARP cleavage was detected in MCF-7 cells at 3 h, whereas only partial PARP cleavage was detected in T47D cells and then only after 24 h. Moreover, staurosporine led to cytochrome c release at 2 h in MCF-7 cells and 6 h in T47D cells.	Staurosporine	166-179	poly(ADP-ribose) polymerase 1	Homo sapiens	89-93
12373608-6	2002	Caspase dependent PARP cleavage was detected in MCF-7 cells at 3 h, whereas only partial PARP cleavage was detected in T47D cells and then only after 24 h. Moreover, staurosporine led to cytochrome c release at 2 h in MCF-7 cells and 6 h in T47D cells.	Staurosporine	166-179	cytochrome c, somatic	Homo sapiens	187-199
12221075-8	2002	Moreover, Bcl-xL but not GPx1 overexpression could suppress the staurosporine-induced late generation of ROS and subsequent cell death.	Staurosporine	64-77	BCL2 like 1	Homo sapiens	10-16
12384259-9	2002	This inhibition was reversed by staurosporine and calphostin C, two protein kinase C (PKC) inhibitors, but not by the third PKC inhibitor, chelerythrine.	Staurosporine	32-45	protein kinase C, gamma	Rattus norvegicus	68-84
12384259-9	2002	This inhibition was reversed by staurosporine and calphostin C, two protein kinase C (PKC) inhibitors, but not by the third PKC inhibitor, chelerythrine.	Staurosporine	32-45	protein kinase C, gamma	Rattus norvegicus	86-89
12491792-0	2002	[Caspase-3-mediated alpha-smooth muscle actin cleavage during staurosporine-induced myofibroblast apoptosis].	Staurosporine	62-75	actin gamma 2, smooth muscle	Rattus norvegicus	20-45
12491792-3	2002	Staurosporine activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 to active forms.	Staurosporine	0-13	caspase 3	Rattus norvegicus	24-33
12491792-3	2002	Staurosporine activated caspase-3 up to 3.6-fold by cleaving pro-caspase-3 to active forms.	Staurosporine	0-13	caspase 3	Rattus norvegicus	65-74
12491792-4	2002	Alpha-smooth muscle actin was degraded during staurosporine-induced apoptosis.	Staurosporine	46-59	actin gamma 2, smooth muscle	Rattus norvegicus	0-25
12491792-5	2002	The degradation of alpha-smooth muscle actin was detected at an early stage of staurosporine-induced apoptosis.	Staurosporine	79-92	actin gamma 2, smooth muscle	Rattus norvegicus	19-44
12491792-6	2002	Recombinant active caspase-3 and staurosporine-stimulated caspase-3 both cleaved purified alpha-smooth muscle actin in vitro.	Staurosporine	33-46	caspase 3	Rattus norvegicus	58-67
12491792-6	2002	Recombinant active caspase-3 and staurosporine-stimulated caspase-3 both cleaved purified alpha-smooth muscle actin in vitro.	Staurosporine	33-46	actin gamma 2, smooth muscle	Rattus norvegicus	90-115
12225992-7	2002	Furthermore, treatment of the cells with staurosporine (ST), an apoptosis inducer that mediates translocation of cyt-c from mitochondria to the cytosol, also increased K+ currents, caused cell shrinkage, and induced apoptosis (determined by apoptotic nuclear morphology and TdT-UTP nick end labeling assay).	Staurosporine	41-54	cytochrome c, somatic	Homo sapiens	113-118
12225992-7	2002	Furthermore, treatment of the cells with staurosporine (ST), an apoptosis inducer that mediates translocation of cyt-c from mitochondria to the cytosol, also increased K+ currents, caused cell shrinkage, and induced apoptosis (determined by apoptotic nuclear morphology and TdT-UTP nick end labeling assay).	Staurosporine	41-54	DNA nucleotidylexotransferase	Homo sapiens	274-277
12225992-7	2002	Furthermore, treatment of the cells with staurosporine (ST), an apoptosis inducer that mediates translocation of cyt-c from mitochondria to the cytosol, also increased K+ currents, caused cell shrinkage, and induced apoptosis (determined by apoptotic nuclear morphology and TdT-UTP nick end labeling assay).	Staurosporine	56-58	cytochrome c, somatic	Homo sapiens	113-118
12225992-7	2002	Furthermore, treatment of the cells with staurosporine (ST), an apoptosis inducer that mediates translocation of cyt-c from mitochondria to the cytosol, also increased K+ currents, caused cell shrinkage, and induced apoptosis (determined by apoptotic nuclear morphology and TdT-UTP nick end labeling assay).	Staurosporine	56-58	DNA nucleotidylexotransferase	Homo sapiens	274-277
12438101-3	2002	The calmodulin antagonist, W13, and the protein kinase C (PKC) inhibitor, staurosporine, each partially depressed Ach-induced glucose transport, with staurosporine exhibiting the stronger inhibitory effect.	Staurosporine	74-87	protein kinase C alpha	Bos taurus	58-61
12084011-0	2002	Staurosporine induces endothelial cell apoptosis via focal adhesion kinase dephosphorylation and focal adhesion disassembly independent of focal adhesion kinase proteolysis.	Staurosporine	0-13	protein tyrosine kinase 2	Homo sapiens	53-74
12084011-3	2002	We examined the relationship between changes in FAK phosphorylation and proteolysis during apoptosis of primary porcine aortic endothelial cells (PAEC) induced by staurosporine, a widely used apoptogenic agent in diverse cell types.	Staurosporine	163-176	protein tyrosine kinase 2	Homo sapiens	48-51
12084011-7	2002	These studies show that FAK dephosphorylation and focal adhesion disassembly are very early events mediating the onset of staurosporine-induced endothelial cell apoptosis and are dissociated from FAK proteolysis.	Staurosporine	122-135	protein tyrosine kinase 2	Homo sapiens	24-27
12204793-5	2002	Staurosporine, an inhibitor of protein kinase C (PKC), inhibited proliferation of SMC induced by bFGF, and both bFGF- and S1P-induced proliferation of SMC was sensitive to pertussis toxin (PTX), an inhibitor of Gi-protein activity.	Staurosporine	0-13	fibroblast growth factor 2	Homo sapiens	97-101
12374772-3	2002	The nonspecific protein kinase inhibitor staurosporine, the specific protein kinase C inhibitor bisindolylmaleimide BIM1, and the protein tyrosine kinase inhibitor genistein reduced the sensitizing effect of IL-1 beta whereas negative controls were ineffective.	Staurosporine	41-54	interleukin 1 beta	Rattus norvegicus	208-217
12370827-3	2002	Treatment of the transfected cells with cisplatin, staurosporine, paclitaxel and doxorubicine showed that BAG-1 p50, p46 and p33 isoforms enhanced the resistance to apoptosis.	Staurosporine	51-64	BAG cochaperone 1	Homo sapiens	106-111
12239113-7	2002	MAPK kinase inhibitor (UO126) and staurosporine reduced calcitriol-mediated betaTC(3) death, and down-regulation of insulin gene transcription was prevented by staurosporine but not UO126.	Staurosporine	160-173	insulin	Homo sapiens	116-123
12207011-4	2002	In contrast, treatment with NCX-4016, but not with aspirin or a non-NO-releasing analogue of NCX-4016, protected HUVEC against the apoptotic actions of staurosporine for up to 8 h. Confocal microscopy demonstrated that although NCX-4016 released NO in subcellular compartments, DETA-NO caused a generalized increase in cytosolic fluorescence.	Staurosporine	152-165	T cell leukemia homeobox 2	Homo sapiens	28-31
12449134-6	2002	2) After addition of PKC inhibitor (staurosporine) in culture medium and culturing PAEC in hypoxic condition immediately, PKC activity and VEGF mRNA in PAEC were measured at the same time.	Staurosporine	36-49	protein kinase C, gamma	Rattus norvegicus	21-24
12323394-0	2002	Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis.	Staurosporine	64-77	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	10-14
12101180-8	2002	The serine/threonine kinase inhibitor, staurosporine (50-200 nm), significantly attenuated 3-NC-induced hyperphosphorylation of ZO-2.	Staurosporine	39-52	tight junction protein 2	Canis lupus familiaris	128-132
12101180-9	2002	This corresponded with attenuation by staurosporine of 3-NC-induced increase in tight junction permeability, suggesting a relationship between ZO-2 phosphorylation and tight junction permeability.	Staurosporine	38-51	tight junction protein 2	Canis lupus familiaris	143-147
12235123-7	2002	Finally, siRNA mediated DEDD knockdown cells exhibited inhibition of staurosporine-induced DNA degradation.	Staurosporine	69-82	death effector domain containing	Homo sapiens	24-28
12107159-4	2002	In this study we demonstrate that endogenous Mst3 is specifically cleaved when Jurkat cells were treated with anti-Fas antibody or staurosporine and that this cleavage is inhibited by the caspase inhibitor, Ac-DEVD-CHO.	Staurosporine	131-144	serine/threonine kinase 24	Homo sapiens	45-49
12199864-5	2002	Overexpression of bcl-2 protected pEC against apoptosis induced by staurosporine or actinomycin D, but failed to prevent hNK cell-mediated lysis.	Staurosporine	67-80	BCL2 apoptosis regulator	Homo sapiens	18-23
12082108-9	2002	Enhanced Akt activation correlated with significant inhibition of staurosporine-induced apoptosis.	Staurosporine	66-79	thymoma viral proto-oncogene 1	Mus musculus	9-12
12176039-0	2002	A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells.	Staurosporine	57-70	cyclin dependent kinase inhibitor 1C	Homo sapiens	44-47
12176039-0	2002	A pro-apoptotic effect of the CDK inhibitor p57(Kip2) on staurosporine-induced apoptosis in HeLa cells.	Staurosporine	57-70	cyclin dependent kinase inhibitor 1C	Homo sapiens	48-52
12176039-3	2002	Here, we report that selective expression of the third member in this family, p57(Kip2), potentiated staurosporine-induced apoptosis in HeLa cells.	Staurosporine	101-114	cyclin dependent kinase inhibitor 1C	Homo sapiens	78-81
12176039-3	2002	Here, we report that selective expression of the third member in this family, p57(Kip2), potentiated staurosporine-induced apoptosis in HeLa cells.	Staurosporine	101-114	cyclin dependent kinase inhibitor 1C	Homo sapiens	82-86
12176039-7	2002	The results presented in this study show that p57(Kip2) has a stimulatory effect on apoptosis induced by staurosporine, suggesting a role for p57(Kip2) in the response of tumor cells to cytotoxic drugs.	Staurosporine	105-118	cyclin dependent kinase inhibitor 1C	Homo sapiens	46-49
12176039-7	2002	The results presented in this study show that p57(Kip2) has a stimulatory effect on apoptosis induced by staurosporine, suggesting a role for p57(Kip2) in the response of tumor cells to cytotoxic drugs.	Staurosporine	105-118	cyclin dependent kinase inhibitor 1C	Homo sapiens	50-54
12176039-7	2002	The results presented in this study show that p57(Kip2) has a stimulatory effect on apoptosis induced by staurosporine, suggesting a role for p57(Kip2) in the response of tumor cells to cytotoxic drugs.	Staurosporine	105-118	cyclin dependent kinase inhibitor 1C	Homo sapiens	142-145
12176039-7	2002	The results presented in this study show that p57(Kip2) has a stimulatory effect on apoptosis induced by staurosporine, suggesting a role for p57(Kip2) in the response of tumor cells to cytotoxic drugs.	Staurosporine	105-118	cyclin dependent kinase inhibitor 1C	Homo sapiens	146-150
11997388-4	2002	Staurosporine attenuated the relocation of PKCalpha-GFP to the cytosol and caused a stepwise accumulation of PKCalpha-GFP at the plasma membrane during ATP stimulation.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	43-51
11997388-4	2002	Staurosporine attenuated the relocation of PKCalpha-GFP to the cytosol and caused a stepwise accumulation of PKCalpha-GFP at the plasma membrane during ATP stimulation.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	109-117
11997388-7	2002	The ionomycin-induced transient translocation of PKCalpha-GFP was prolonged by staurosporine, diacylglycerol, and phorbol myristate acetate.	Staurosporine	79-92	protein kinase C alpha	Homo sapiens	49-57
11997388-8	2002	Experiments using permeabilized cells showed that staurosporine or the elimination of ATP and Mg2+ decreases the rate of dissociation of PKCalpha-GFP from the membrane.	Staurosporine	50-63	protein kinase C alpha	Homo sapiens	137-145
12135894-9	2002	Plk1 disappeared at the spindle region when microtubule formation was inhibited by colchicine or staurosporine, while it was concentrated as several dots in the cytoplasm after taxol treatment.	Staurosporine	97-110	polo like kinase 1	Mus musculus	0-4
12154052-10	2002	Both DNAS1L3-mediated and staurosporine-induced internucleosomal DNA fragmentation were Ca(2+) dependent, but only the DNAS1L3-mediated DNA cleavage was blocked by expression of a caspase-3-resistant mutant of poly(ADP-ribose) polymerase-1.	Staurosporine	26-39	caspase 3	Homo sapiens	180-189
12154052-10	2002	Both DNAS1L3-mediated and staurosporine-induced internucleosomal DNA fragmentation were Ca(2+) dependent, but only the DNAS1L3-mediated DNA cleavage was blocked by expression of a caspase-3-resistant mutant of poly(ADP-ribose) polymerase-1.	Staurosporine	26-39	poly(ADP-ribose) polymerase 1	Homo sapiens	210-239
12190943-9	2002	The effect of staurosporine could be explained by its paradoxical action (activation) on protein kinase C (PKC) in keratinocytes.	Staurosporine	14-27	protein kinase C alpha	Homo sapiens	107-110
12097139-1	2002	Using green fluorescent protein-tagged Bax, we demonstrate that Bax is sequestered from the cytosol of cardiomyocytes in two distinct phases following the induction of apoptosis with staurosporine.	Staurosporine	183-196	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
12097139-5	2002	The cytochrome c fusion protein was accumulated by mitochondria of healthy cells and was released by staurosporine in phase 1.	Staurosporine	101-114	cytochrome c, somatic	Homo sapiens	4-16
12220631-6	2002	Activation of AtMPK6 and AtMPK3 by hypoosmolarity depended on upstream protein kinases sensitive to staurosporine and on calcium influx.	Staurosporine	100-113	MAP kinase 6	Arabidopsis thaliana	14-20
12220631-6	2002	Activation of AtMPK6 and AtMPK3 by hypoosmolarity depended on upstream protein kinases sensitive to staurosporine and on calcium influx.	Staurosporine	100-113	mitogen-activated protein kinase 3	Arabidopsis thaliana	25-31
12049820-0	2002	Staurosporine-induced G(1) arrest in cancer cells depends on an intact pRB but is independent of p16 status.	Staurosporine	0-13	RB transcriptional corepressor 1	Homo sapiens	71-74
12049820-0	2002	Staurosporine-induced G(1) arrest in cancer cells depends on an intact pRB but is independent of p16 status.	Staurosporine	0-13	cyclin dependent kinase inhibitor 2A	Homo sapiens	97-100
12049820-2	2002	Several recent studies have shown that cells with defective pRB protein are resistant to the G(1) cell cycle-inhibiting effects of staurosporine compounds.	Staurosporine	131-144	RB transcriptional corepressor 1	Homo sapiens	60-63
12049820-4	2002	All of these p16-deficient cell lines are highly sensitive to staurosporine-induced inhibition of pRB phosphorylation and induction of arrest in G(1).	Staurosporine	62-75	cyclin dependent kinase inhibitor 2A	Homo sapiens	13-16
12049820-4	2002	All of these p16-deficient cell lines are highly sensitive to staurosporine-induced inhibition of pRB phosphorylation and induction of arrest in G(1).	Staurosporine	62-75	RB transcriptional corepressor 1	Homo sapiens	98-101
12049820-5	2002	This response is similar to that seen in cultured normal human bronchial epithelial cells and normal mammary epithelial cells, but strikingly different than the staurosporine resistance seen in cancer cells with defective pRB.	Staurosporine	161-174	RB transcriptional corepressor 1	Homo sapiens	222-225
12049820-6	2002	Interestingly, inhibition of pRB phosphorylation could be seen within 4 h of treatment, suggesting that this inhibition is a consequence of direct effects of staurosporine on protein kinase(s) rather than a result of induction of other cyclin-dependent kinase inhibitors.	Staurosporine	158-171	RB transcriptional corepressor 1	Homo sapiens	29-32
12049820-7	2002	Our findings suggest that different types of cancer cells have vastly different responses to the staurosporine class of agents, and that evaluation of pRB and p16 will help predict the response of the cancer cells to these agents.	Staurosporine	97-110	RB transcriptional corepressor 1	Homo sapiens	151-154
12215493-5	2002	Inhibition of phospholipase C (PLC) with U-73122 and suppression of protein kinase C (PKC) with staurosporine and GF-109203X markedly attenuated the apelin-induced inotropic effect (P&lt;0.001).	Staurosporine	96-109	apelin	Rattus norvegicus	149-155
12193414-6	2002	Provision of staurosporine, a potent inhibitor of the catalytic subunit of PKC, produced significant dose-dependent decrements in the relative expression of IGFBP-5 transcripts.	Staurosporine	13-26	protein kinase C, gamma	Rattus norvegicus	75-78
12193414-6	2002	Provision of staurosporine, a potent inhibitor of the catalytic subunit of PKC, produced significant dose-dependent decrements in the relative expression of IGFBP-5 transcripts.	Staurosporine	13-26	insulin-like growth factor binding protein 5	Rattus norvegicus	157-164
12183337-13	2002	Staurosporine inhibited the culture induced upregulation of the response of both the ET(A) and the 5-HT(1B/1D) receptors, but had no significant effect on the mRNA levels of these receptors.	Staurosporine	0-13	5-hydroxytryptamine receptor 1B	Rattus norvegicus	99-106
12372016-9	2002	The enhancement of EPSCs could be blocked by the intracellular presence of the kinase inhibitor staurosporine (1 micro m), suggesting the involvement of a postsynaptic phosphorylation cascade rather then presynaptic release mechanisms at CA3 c/a synapses.	Staurosporine	96-109	carbonic anhydrase 3	Rattus norvegicus	238-241
12225366-7	2002	In contrast staurosporine, a serine/threonine kinase inhibitor, increased adherence of macrophages and yet prohibited the adhesion-dependent increase in krox-20/egr-2 gene expression.	Staurosporine	12-25	early growth response 2	Rattus norvegicus	153-160
12225366-7	2002	In contrast staurosporine, a serine/threonine kinase inhibitor, increased adherence of macrophages and yet prohibited the adhesion-dependent increase in krox-20/egr-2 gene expression.	Staurosporine	12-25	early growth response 2	Rattus norvegicus	161-166
12225366-11	2002	The up-regulation of krox-20/egr-2 gene due to the homophilic cell aggregation was also inhibited either by piceatannol or staurosporine.	Staurosporine	123-136	early growth response 2	Rattus norvegicus	21-28
12225366-11	2002	The up-regulation of krox-20/egr-2 gene due to the homophilic cell aggregation was also inhibited either by piceatannol or staurosporine.	Staurosporine	123-136	early growth response 2	Rattus norvegicus	29-34
12225366-12	2002	Those results suggest that krox-20/egr-2 gene expression is triggered by sensing non-specific and homophilic cellular adhesion and the following phosphorylation of signal transducing proteins including Syk and staurosporine-inhibitable kinases.	Staurosporine	210-223	early growth response 2	Rattus norvegicus	27-34
12225366-12	2002	Those results suggest that krox-20/egr-2 gene expression is triggered by sensing non-specific and homophilic cellular adhesion and the following phosphorylation of signal transducing proteins including Syk and staurosporine-inhibitable kinases.	Staurosporine	210-223	early growth response 2	Rattus norvegicus	35-40
12210828-8	2002	The protection by GDNF expression against staurosporine was mediated through both phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase kinase (MAPK kinase; MEK) pathways, but only the MEK pathway was involved in the protection against SNAP.	Staurosporine	42-55	glial cell derived neurotrophic factor	Rattus norvegicus	18-22
12127563-4	2002	The results presented here demonstrate that the treatment of Jurkat cells with the apoptosis inducers anti-Fas, TRAIL, staurosporine, and etoposide induces proteolytic fragments of beta-catenin, as did TRAIL and staurosporine in U937 cells.	Staurosporine	119-132	catenin beta 1	Homo sapiens	181-193
12127563-4	2002	The results presented here demonstrate that the treatment of Jurkat cells with the apoptosis inducers anti-Fas, TRAIL, staurosporine, and etoposide induces proteolytic fragments of beta-catenin, as did TRAIL and staurosporine in U937 cells.	Staurosporine	119-132	TNF superfamily member 10	Homo sapiens	202-207
12127563-4	2002	The results presented here demonstrate that the treatment of Jurkat cells with the apoptosis inducers anti-Fas, TRAIL, staurosporine, and etoposide induces proteolytic fragments of beta-catenin, as did TRAIL and staurosporine in U937 cells.	Staurosporine	212-225	TNF superfamily member 10	Homo sapiens	112-117
12127563-4	2002	The results presented here demonstrate that the treatment of Jurkat cells with the apoptosis inducers anti-Fas, TRAIL, staurosporine, and etoposide induces proteolytic fragments of beta-catenin, as did TRAIL and staurosporine in U937 cells.	Staurosporine	212-225	catenin beta 1	Homo sapiens	181-193
12164862-3	2002	RESULTS: TGF-beta up-regulated FN mRNA accumulation in a time- and dose-dependent manner, which was completely inhibited by phosphatidylcholine-phospholipase C (PC-PLC) inhibitor and PKC inhibitors (calphostin-C and staurosporin).	Staurosporine	216-228	transforming growth factor beta 1	Homo sapiens	9-17
12164862-3	2002	RESULTS: TGF-beta up-regulated FN mRNA accumulation in a time- and dose-dependent manner, which was completely inhibited by phosphatidylcholine-phospholipase C (PC-PLC) inhibitor and PKC inhibitors (calphostin-C and staurosporin).	Staurosporine	216-228	fibronectin 1	Homo sapiens	31-33
12210846-7	2002	In contrast, PS1 wt transgenic neurons were resistant to apoptosis induced by Golgi-ER toxins but displayed a comparable vulnerability to staurosporine.	Staurosporine	138-151	presenilin 1	Mus musculus	13-16
12162751-12	2002	PKCzeta thus functions as an adaptor, associating with a staurosporine-insensitive PDK2 enzyme that catalyzes the phosphorylation of S472 of PKBgamma.	Staurosporine	57-70	AKT serine/threonine kinase 3	Homo sapiens	141-149
12420861-2	2002	To increase sensitivity and specificity of RT-PCR, CEA transcript was selectively up-regulated in cancer cells by exposure of peripheral blood to non-toxic concentrations of staurosporine (ST).	Staurosporine	174-187	CEA cell adhesion molecule 3	Homo sapiens	51-54
12420861-2	2002	To increase sensitivity and specificity of RT-PCR, CEA transcript was selectively up-regulated in cancer cells by exposure of peripheral blood to non-toxic concentrations of staurosporine (ST).	Staurosporine	189-191	CEA cell adhesion molecule 3	Homo sapiens	51-54
12221584-9	2002	These effects of PLAB on the activation of endogenous PPARalpha and phospholipase C-dependent pathway were blocked by staurosporine.	Staurosporine	118-131	peroxisome proliferator activated receptor alpha	Rattus norvegicus	54-63
12177808-0	2002	Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines.	Staurosporine	57-70	urocortin	Homo sapiens	82-85
12123737-0	2002	Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line.	Staurosporine	33-46	prostaglandin-endoperoxide synthase 2	Mus musculus	13-29
12123737-0	2002	Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line.	Staurosporine	33-46	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	92-96
12123737-0	2002	Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line.	Staurosporine	33-46	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	98-104
12123737-0	2002	Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line.	Staurosporine	33-46	transcription factor AP-2, alpha	Mus musculus	110-129
12123737-0	2002	Induction of cyclooxygenase-2 by staurosporine through the activation of nuclear factor for IL-6 (NF-IL6) and activator protein 2 (AP2) in an osteoblast-like cell line.	Staurosporine	33-46	transcription factor AP-2, alpha	Mus musculus	131-134
12123737-3	2002	Staurosporine, a potential anti-tumor drug, was found recently to up-regulate the expression of the COX-2 gene in the mouse osteoblast-like cell line MC3T3-E1.	Staurosporine	0-13	prostaglandin-endoperoxide synthase 2	Mus musculus	100-105
12123737-4	2002	The ability of staurosporine to induce the expression of the COX-2 gene was investigated using luciferase reporters controlled by various COX-2 core promoter regions.	Staurosporine	15-28	prostaglandin-endoperoxide synthase 2	Mus musculus	61-66
12123737-4	2002	The ability of staurosporine to induce the expression of the COX-2 gene was investigated using luciferase reporters controlled by various COX-2 core promoter regions.	Staurosporine	15-28	prostaglandin-endoperoxide synthase 2	Mus musculus	138-143
12123737-5	2002	Two cis-acting sites for activator protein 2 (AP2) and nuclear factor for IL-6 (NF-IL6), respectively, were identified as responsible for the staurosporine-mediated COX-2 up-regulation.	Staurosporine	142-155	transcription factor AP-2, alpha	Mus musculus	25-44
12123737-5	2002	Two cis-acting sites for activator protein 2 (AP2) and nuclear factor for IL-6 (NF-IL6), respectively, were identified as responsible for the staurosporine-mediated COX-2 up-regulation.	Staurosporine	142-155	transcription factor AP-2, alpha	Mus musculus	46-49
12123737-5	2002	Two cis-acting sites for activator protein 2 (AP2) and nuclear factor for IL-6 (NF-IL6), respectively, were identified as responsible for the staurosporine-mediated COX-2 up-regulation.	Staurosporine	142-155	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	74-78
12123737-5	2002	Two cis-acting sites for activator protein 2 (AP2) and nuclear factor for IL-6 (NF-IL6), respectively, were identified as responsible for the staurosporine-mediated COX-2 up-regulation.	Staurosporine	142-155	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	80-86
12234376-3	2002	RESULTS: BRCA1wt and BRCA1+ cells were treated with staurosporine.	Staurosporine	52-65	BRCA1 DNA repair associated	Homo sapiens	9-14
12234376-3	2002	RESULTS: BRCA1wt and BRCA1+ cells were treated with staurosporine.	Staurosporine	52-65	BRCA1 DNA repair associated	Homo sapiens	21-26
12234376-6	2002	Western immunoblot analysis revealed that caspase 3 levels were higher after staurosporine treatment in BRCA1+ cells than in wild type cells, while full length DNA Fragmentation Factor 45 levels were lower in BRCA1+ cells.	Staurosporine	77-90	caspase 3	Homo sapiens	42-51
12234376-6	2002	Western immunoblot analysis revealed that caspase 3 levels were higher after staurosporine treatment in BRCA1+ cells than in wild type cells, while full length DNA Fragmentation Factor 45 levels were lower in BRCA1+ cells.	Staurosporine	77-90	BRCA1 DNA repair associated	Homo sapiens	104-109
11955957-5	2002	The PKC inhibitors, chelerytrine (Che), staurosporine (St) and Go 6976, prevented PMA inhibitory effect on lysosomal proteolysis.	Staurosporine	40-53	protein kinase C, gamma	Rattus norvegicus	4-7
11955957-5	2002	The PKC inhibitors, chelerytrine (Che), staurosporine (St) and Go 6976, prevented PMA inhibitory effect on lysosomal proteolysis.	Staurosporine	55-57	protein kinase C, gamma	Rattus norvegicus	4-7
12019309-7	2002	In cultured rat hippocampal cells, TGF-beta1 inhibited the increase in Bad expression caused by staurosporine.	Staurosporine	96-109	transforming growth factor, beta 1	Rattus norvegicus	35-44
12176659-7	2002	Staurosporine, an inhibitor of protein kinases C (PKC), inhibited the AT1 desensitisation.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	50-53
12176659-7	2002	Staurosporine, an inhibitor of protein kinases C (PKC), inhibited the AT1 desensitisation.	Staurosporine	0-13	angiotensin II receptor type 1	Homo sapiens	70-73
12123737-5	2002	Two cis-acting sites for activator protein 2 (AP2) and nuclear factor for IL-6 (NF-IL6), respectively, were identified as responsible for the staurosporine-mediated COX-2 up-regulation.	Staurosporine	142-155	prostaglandin-endoperoxide synthase 2	Mus musculus	165-170
12123737-11	2002	This finding implies that staurosporine-mediated COX-2 gene expression is specific and independent of protein kinase C activity.	Staurosporine	26-39	prostaglandin-endoperoxide synthase 2	Mus musculus	49-54
12083800-8	2002	The CG exocytosis and PKC redistribution induced by PMA could be blocked by the PKC inhibitor staurosporine.	Staurosporine	94-107	protein kinase C alpha	Homo sapiens	22-25
12083800-8	2002	The CG exocytosis and PKC redistribution induced by PMA could be blocked by the PKC inhibitor staurosporine.	Staurosporine	94-107	protein kinase C alpha	Homo sapiens	80-83
12119347-5	2002	Furthermore, the increase in HDC activity upon sensitization with IgE was completely suppressed by pretreatment of BMMCs with protein kinase C inhibitors, such as H7, staurosporine, and Go6976.	Staurosporine	167-180	histidine decarboxylase	Mus musculus	29-32
12150976-1	2002	We reported previously that human prostate cancer cell line TSU-Pr1 can differentiate into neuronal cells by staurosporine treatment.	Staurosporine	109-122	transmembrane protein 37	Homo sapiens	64-67
12150976-2	2002	In this process, reduction of invasive abilities was observed in staurosporine treated TSU-Pr1 cells.	Staurosporine	65-78	transmembrane protein 37	Homo sapiens	91-94
12150976-4	2002	We show that treatment of TSU-Pr1 cells with staurosporine results in induction of TIMP-1 mRNA and protein secretion.	Staurosporine	45-58	transmembrane protein 37	Homo sapiens	30-33
12150976-4	2002	We show that treatment of TSU-Pr1 cells with staurosporine results in induction of TIMP-1 mRNA and protein secretion.	Staurosporine	45-58	TIMP metallopeptidase inhibitor 1	Homo sapiens	83-89
12150976-5	2002	The induction of TIMP-1 mRNA expression by staurosporine is likely to be caused by increased transcriptional activity and this mechanism is indirect.	Staurosporine	43-56	TIMP metallopeptidase inhibitor 1	Homo sapiens	17-23
12150976-7	2002	We are the first to report that mRNA expression and protein secretion of TIMP-1 are enhanced by staurosporine treatment in prostate cancer cells.	Staurosporine	96-109	TIMP metallopeptidase inhibitor 1	Homo sapiens	73-79
12150976-8	2002	These findings suggest that enhancement of TIMP-1 is associated with suppression of invasive activity caused by staurosporine treatment.	Staurosporine	112-125	TIMP metallopeptidase inhibitor 1	Homo sapiens	43-49
12058280-0	2002	Defective Bax activation in Hodgkin B-cell lines confers resistance to staurosporine-induced apoptosis.	Staurosporine	71-84	BCL2 associated X, apoptosis regulator	Homo sapiens	10-13
12058280-6	2002	In staurosporine-treated Hodgkin cells Bax remained in its inactive state, indicating that these cell lines have a defect in this crucial step in apoptotic signaling upstream of the mitochondria.	Staurosporine	3-16	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
12184411-7	2002	CONCLUSION: These bulky adenosine triphosphate antagonists derived from K252a or related indolocarbazole compounds such as staurosporine would be potentially useful for the treatment of RAS/ PAK1-induced cancers, once their anti-PAK1 activity is significantly potentiated by a few additional chemical modifications at the sugar ring suggested in this paper.	Staurosporine	123-136	p21 (RAC1) activated kinase 1	Mus musculus	191-195
12184411-7	2002	CONCLUSION: These bulky adenosine triphosphate antagonists derived from K252a or related indolocarbazole compounds such as staurosporine would be potentially useful for the treatment of RAS/ PAK1-induced cancers, once their anti-PAK1 activity is significantly potentiated by a few additional chemical modifications at the sugar ring suggested in this paper.	Staurosporine	123-136	p21 (RAC1) activated kinase 1	Mus musculus	229-233
12051665-4	2002	As a positive control for apoptosis, ECV304 cells were treated with staurosporine, which indeed caused significant activation of caspase-3 activity, DNA laddering, and cytochrome c release.	Staurosporine	68-81	caspase 3	Homo sapiens	129-138
12051665-4	2002	As a positive control for apoptosis, ECV304 cells were treated with staurosporine, which indeed caused significant activation of caspase-3 activity, DNA laddering, and cytochrome c release.	Staurosporine	68-81	cytochrome c, somatic	Homo sapiens	168-180
12027457-5	2002	Release of snRNP was also inhibited when transcription was blocked in the presence of 9-beta-D-arabinofuranosyladenine, to inhibit 3"-end cleavage and polyadenylation, or staurosporine, to inhibit kinases.	Staurosporine	171-184	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	11-16
12037665-3	2002	In the current study, we report the first evidence that endogenous maspin expression in mammary carcinoma cells MDA-MB-435 enhanced staurosporine (STS)-induced apoptosis as judged by the increased fragmentation of DNA, increased proteolytic inactivation of poly-[ADP-ribose]-polymerase (PARP), as well as the increased activation of caspase-8 and caspase-3.	Staurosporine	132-145	serpin family B member 5	Homo sapiens	67-73
12037665-3	2002	In the current study, we report the first evidence that endogenous maspin expression in mammary carcinoma cells MDA-MB-435 enhanced staurosporine (STS)-induced apoptosis as judged by the increased fragmentation of DNA, increased proteolytic inactivation of poly-[ADP-ribose]-polymerase (PARP), as well as the increased activation of caspase-8 and caspase-3.	Staurosporine	147-150	serpin family B member 5	Homo sapiens	67-73
11909872-4	2002	Importantly, restoration of DU-145 Bax expression via adenoviral gene transfer restored ER Ca(2+) release and mitochondrial Ca(2+) uptake and dramatically accelerated the kinetics of staurosporine-induced cytochrome c release, demonstrating a requirement for Bax expression in this model system.	Staurosporine	183-196	BCL2 associated X, apoptosis regulator	Homo sapiens	35-38
11909872-4	2002	Importantly, restoration of DU-145 Bax expression via adenoviral gene transfer restored ER Ca(2+) release and mitochondrial Ca(2+) uptake and dramatically accelerated the kinetics of staurosporine-induced cytochrome c release, demonstrating a requirement for Bax expression in this model system.	Staurosporine	183-196	cytochrome c, somatic	Homo sapiens	205-217
11909872-4	2002	Importantly, restoration of DU-145 Bax expression via adenoviral gene transfer restored ER Ca(2+) release and mitochondrial Ca(2+) uptake and dramatically accelerated the kinetics of staurosporine-induced cytochrome c release, demonstrating a requirement for Bax expression in this model system.	Staurosporine	183-196	BCL2 associated X, apoptosis regulator	Homo sapiens	259-262
12067896-4	2002	Because conventional inhibitors of PKC, such as staurosporine or calphostin C, also inhibit a variety of other protein kinases, we used a novel compound to specifically inhibit PKC.	Staurosporine	48-61	proline rich transmembrane protein 2	Homo sapiens	35-38
12067896-4	2002	Because conventional inhibitors of PKC, such as staurosporine or calphostin C, also inhibit a variety of other protein kinases, we used a novel compound to specifically inhibit PKC.	Staurosporine	48-61	proline rich transmembrane protein 2	Homo sapiens	177-180
12032672-6	2002	In contrast, staurosporine-induced apoptosis in these cells was accompanied by proteolytic cleavage of pro-caspase-3 and induction of caspase-3 enzymatic activity.	Staurosporine	13-26	caspase 3	Homo sapiens	103-116
12032672-6	2002	In contrast, staurosporine-induced apoptosis in these cells was accompanied by proteolytic cleavage of pro-caspase-3 and induction of caspase-3 enzymatic activity.	Staurosporine	13-26	caspase 3	Homo sapiens	107-116
12107546-1	2002	PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other"s activation.	Staurosporine	43-56	proline rich transmembrane protein 2	Homo sapiens	124-140
12107546-1	2002	PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other"s activation.	Staurosporine	43-56	proline rich transmembrane protein 2	Homo sapiens	142-145
12107546-1	2002	PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other"s activation.	Staurosporine	43-56	H3 histone pseudogene 16	Homo sapiens	181-184
12107546-1	2002	PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other"s activation.	Staurosporine	43-56	proline rich transmembrane protein 2	Homo sapiens	220-223
12107546-1	2002	PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other"s activation.	Staurosporine	43-56	mitogen-activated protein kinase 8	Homo sapiens	228-249
12107546-1	2002	PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other"s activation.	Staurosporine	43-56	mitogen-activated protein kinase 8	Homo sapiens	251-254
12107546-1	2002	PURPOSE: We have previously found that the staurosporine derivative, CGP 41 251, that has a high specificity for inhibiting protein kinase C (PKC), selectively blocks oncogenic ras-p21-induced oocyte maturation and that PKC and jun-N-terminal kinase (JNK), with which oncogenic ras-p21 directly interacts, reciprocally require each other"s activation.	Staurosporine	43-56	H3 histone pseudogene 16	Homo sapiens	282-285
12072455-5	2002	Although the sth1-3ts mutant exhibits defects characteristic of PKC1 pathway mutants (caffeine and staurosporine sensitivities and an osmoremedial phenotype), only upstream components and not downstream effectors of the PKC1-MAP kinase pathway can suppress defects conferred by sth1-3ts, suggesting that RSC functions in an alternative PKC1-dependent pathway.	Staurosporine	99-112	RSC chromatin remodeling complex ATPase subunit STH1	Saccharomyces cerevisiae S288C	13-17
12065619-8	2002	Importantly, after mitochondrial-mediated apoptosis by staurosporine, a rapid loss of mitochondrial membrane potential was found in tTG cells only.	Staurosporine	55-68	transglutaminase 2, C polypeptide	Mus musculus	132-135
12113554-11	2002	In addition, H7, staurosporine, cycloheximide and TGF-beta could suppress MMP-2 production.	Staurosporine	17-30	matrix metallopeptidase 2	Homo sapiens	74-79
12051998-2	2002	Herein we show that hyperthermia, 4-hydroperoxycyclophosphamide, and staurosporine also activate caspase-9, the apical caspase in the mitochondrial apoptotic pathway.	Staurosporine	69-82	caspase 9	Mus musculus	97-106
12579796-9	2002	Furthermore, the results showed that STP blocked decrease of cyclin B1 expression induced by X-ray, while mitotic index measurement indicated that X-ray-irradiated cells treated with STP entered mitosis.	Staurosporine	37-40	cyclin B1	Homo sapiens	61-70
11994256-9	2002	The effects of SIN-1 were blocked by the NO scavenger phenyl-tetramethyl-imidazoline-oxyl-oxide as well as by the PKC inhibitor staurosporine.	Staurosporine	128-141	MAPK associated protein 1	Homo sapiens	15-20
11983288-3	2002	Here we investigate the processing and activation of caspases 3, 6 and 7 in rat C6 glioma cells induced to undergo apoptosis by staurosporine (STS) treatment as a model of apoptosis in glia.	Staurosporine	128-141	caspase 6	Rattus norvegicus	53-61
11983288-3	2002	Here we investigate the processing and activation of caspases 3, 6 and 7 in rat C6 glioma cells induced to undergo apoptosis by staurosporine (STS) treatment as a model of apoptosis in glia.	Staurosporine	143-146	caspase 6	Rattus norvegicus	53-61
11994256-9	2002	The effects of SIN-1 were blocked by the NO scavenger phenyl-tetramethyl-imidazoline-oxyl-oxide as well as by the PKC inhibitor staurosporine.	Staurosporine	128-141	protein kinase C alpha	Homo sapiens	114-117
11955473-0	2002	Release of cytochrome c into the extracellular space contributes to neuronal apoptosis induced by staurosporine.	Staurosporine	98-111	cytochrome c, somatic	Homo sapiens	11-23
11955473-2	2002	In the present study, we used primary neuronal cultures to investigate whether cytochrome c was released from the mitochondria into the cytosol and subsequently into the culture medium during staurosporine-induced apoptosis and whether extracellular cytochrome c modulates the degree of damage caused by staurosporine.	Staurosporine	192-205	cytochrome c, somatic	Homo sapiens	79-91
11955473-3	2002	We found the cytochrome c content in the mitochondria decreased 24 h after and increased in the cytosol 8 h after staurosporine was added to the culture medium.	Staurosporine	114-127	cytochrome c, somatic	Homo sapiens	13-25
11955473-4	2002	The cytochrome c content of the culture medium increased from 8 h up to 24 h after starting the staurosporine treatment.	Staurosporine	96-109	cytochrome c, somatic	Homo sapiens	4-16
11955473-6	2002	Addition of cytochrome c accelerated, whereas the addition of anti-cytochrome c antibodies reduced staurosporine-induced neuronal death suggesting a pro-apoptotic role of cytochrome c released into the culture medium.	Staurosporine	99-112	cytochrome c, somatic	Homo sapiens	67-79
11955473-6	2002	Addition of cytochrome c accelerated, whereas the addition of anti-cytochrome c antibodies reduced staurosporine-induced neuronal death suggesting a pro-apoptotic role of cytochrome c released into the culture medium.	Staurosporine	99-112	cytochrome c, somatic	Homo sapiens	67-79
11955473-7	2002	Under control conditions, extracellularly added cytochrome c (25 ng/ml), which was in the range of the amount of cytochrome c released from staurosporine-treated neurons into the culture medium, increased the percentage of apoptotic neurons to 30% compared with 18% in vehicle-treated controls.	Staurosporine	140-153	cytochrome c, somatic	Homo sapiens	48-60
11955473-7	2002	Under control conditions, extracellularly added cytochrome c (25 ng/ml), which was in the range of the amount of cytochrome c released from staurosporine-treated neurons into the culture medium, increased the percentage of apoptotic neurons to 30% compared with 18% in vehicle-treated controls.	Staurosporine	140-153	cytochrome c, somatic	Homo sapiens	113-125
11955473-8	2002	Our results suggest that the release of cytochrome c into the extracellular space contributes to neuronal apoptosis induced by staurosporine.	Staurosporine	127-140	cytochrome c, somatic	Homo sapiens	40-52
11973615-5	2002	Resistance of the mutant Jurkat cells was specific for FasL killing, since the mutant clones were sensitive to other apoptotic stimuli such as cycloheximide and staurosporine.	Staurosporine	161-174	Fas ligand	Homo sapiens	55-59
11959692-8	2002	The nonspecific protein kinase inhibitor staurosporine blocked forskolin-induced inhibition of ANP release in a dose-dependent manner.	Staurosporine	41-54	natriuretic peptides A	Oryctolagus cuniculus	95-98
11959692-9	2002	Staurosporine but not nifedipine shifted the relationship between cAMP and ANP release.	Staurosporine	0-13	natriuretic peptides A	Oryctolagus cuniculus	75-78
12089597-7	2002	The specificity of the response to PKC was confirmed by using the kinase inhibitor staurosporine or the inactive phorbol ester 4-alpha-PMA.	Staurosporine	83-96	protein kinase C, gamma	Rattus norvegicus	35-38
11960552-11	2002	Hyal-2 translocated from the lysosome to the mitochondria during staurosporine-mediated apoptosis, suggesting that Hyal-2 may damage mitochondria.	Staurosporine	65-78	hyaluronoglucosaminidase 2	Mus musculus	0-6
12065637-4	2002	In these studies three different apoptotic stimuli were used osmotic stress, staurosporine treatment and heat shock to delineate the role of tissue transglutaminase as a transamidating enzyme in the apoptotic process.	Staurosporine	77-90	transglutaminase 2	Homo sapiens	141-164
12065637-5	2002	In SH/tTG cells, osmotic stress and staurosporine treatments resulted in significantly greater caspase-3 activation and apoptotic nuclear changes then in SH/pcDNA or SH/C277S cells.	Staurosporine	36-49	caspase 3	Homo sapiens	95-104
11967922-15	2002	Work from my laboratory in the last 5 years has shown that teratogens, such as hyperthermia, 4-hydroperoxycyclophosphamide, and staurosporine, induce cell death in day 9 mouse embryos by activating the mitochondrial apoptotic pathway, i.e., mitochondrial release of cytochrome c, activation of caspase-9 and -3, inactivation of poly (ADP-ribose) polymerase (PARP), and systematic degradation of DNA.	Staurosporine	128-141	cytochrome c, somatic	Homo sapiens	266-278
11967922-15	2002	Work from my laboratory in the last 5 years has shown that teratogens, such as hyperthermia, 4-hydroperoxycyclophosphamide, and staurosporine, induce cell death in day 9 mouse embryos by activating the mitochondrial apoptotic pathway, i.e., mitochondrial release of cytochrome c, activation of caspase-9 and -3, inactivation of poly (ADP-ribose) polymerase (PARP), and systematic degradation of DNA.	Staurosporine	128-141	caspase 9	Mus musculus	294-310
11967922-15	2002	Work from my laboratory in the last 5 years has shown that teratogens, such as hyperthermia, 4-hydroperoxycyclophosphamide, and staurosporine, induce cell death in day 9 mouse embryos by activating the mitochondrial apoptotic pathway, i.e., mitochondrial release of cytochrome c, activation of caspase-9 and -3, inactivation of poly (ADP-ribose) polymerase (PARP), and systematic degradation of DNA.	Staurosporine	128-141	poly (ADP-ribose) polymerase family, member 1	Mus musculus	328-356
11967922-15	2002	Work from my laboratory in the last 5 years has shown that teratogens, such as hyperthermia, 4-hydroperoxycyclophosphamide, and staurosporine, induce cell death in day 9 mouse embryos by activating the mitochondrial apoptotic pathway, i.e., mitochondrial release of cytochrome c, activation of caspase-9 and -3, inactivation of poly (ADP-ribose) polymerase (PARP), and systematic degradation of DNA.	Staurosporine	128-141	poly (ADP-ribose) polymerase family, member 1	Mus musculus	358-362
11842081-3	2002	We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm.	Staurosporine	173-186	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
11842081-3	2002	We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm.	Staurosporine	173-186	BCL2 associated X, apoptosis regulator	Homo sapiens	195-198
11842081-3	2002	We found that LY294002, a PI3K inhibitor, blocked the effects of serum to prevent Bax translocation to mitochondria and that expression of an active form of PI3K suppressed staurosporine-induced Bax translocation, suggesting that PI3K activity is essential for retaining Bax in the cytoplasm.	Staurosporine	173-186	BCL2 associated X, apoptosis regulator	Homo sapiens	195-198
11842081-5	2002	In respect to downstream effectors of PI3K, we found that expression of active Akt, but not serum and glucocorticoid-induced protein kinase (SGK), suppressed staurosporine-induced translocation of Bax, whereas dominant negative Akt moderately promoted Bax translocation.	Staurosporine	158-171	AKT serine/threonine kinase 1	Homo sapiens	79-82
11842081-5	2002	In respect to downstream effectors of PI3K, we found that expression of active Akt, but not serum and glucocorticoid-induced protein kinase (SGK), suppressed staurosporine-induced translocation of Bax, whereas dominant negative Akt moderately promoted Bax translocation.	Staurosporine	158-171	BCL2 associated X, apoptosis regulator	Homo sapiens	197-200
11948667-3	2002	In the present study, we first compared the vulnerability of cultured neurons prepared from APOE-knockout mice upon exposure to glutamate, hydrogen peroxide, and staurosporine.	Staurosporine	162-175	apolipoprotein E	Mus musculus	92-96
11796722-7	2002	Staurosporine and Go6983, inhibitors for PKC, also inhibited the induction of Prx I, suggesting that protein kinase Cdelta is required for the induction by arsenate.	Staurosporine	0-13	protein kinase C, delta	Mus musculus	41-44
11796722-7	2002	Staurosporine and Go6983, inhibitors for PKC, also inhibited the induction of Prx I, suggesting that protein kinase Cdelta is required for the induction by arsenate.	Staurosporine	0-13	peroxiredoxin 1	Mus musculus	78-83
11796722-7	2002	Staurosporine and Go6983, inhibitors for PKC, also inhibited the induction of Prx I, suggesting that protein kinase Cdelta is required for the induction by arsenate.	Staurosporine	0-13	protein kinase C, delta	Mus musculus	101-122
11960552-11	2002	Hyal-2 translocated from the lysosome to the mitochondria during staurosporine-mediated apoptosis, suggesting that Hyal-2 may damage mitochondria.	Staurosporine	65-78	hyaluronoglucosaminidase 2	Mus musculus	115-121
11897711-14	2002	The AVP-stimulated PTHrP release was blocked by staurosporine (PKC inhibitor), nicardipine (L-type calcium channel blocker) or omega-agatoxin IVA (N type).	Staurosporine	48-61	parathyroid hormone like hormone	Homo sapiens	19-24
11965494-0	2002	PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway.	Staurosporine	14-27	phosphatase and tensin homolog	Homo sapiens	0-4
11965494-0	2002	PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway.	Staurosporine	14-27	phosphatase and tensin homolog	Homo sapiens	49-53
11965494-2	2002	We investigated the involvement of PTEN in staurosporine-induced apoptosis.	Staurosporine	43-56	phosphatase and tensin homolog	Homo sapiens	35-39
11965494-11	2002	Staurosporine reduced the levels of phospho-Akt/PKB and phospho-Bad (Ser-136) in all the cell lines, but the reduction was most significant in the PTEN-expressing clone.	Staurosporine	0-13	phosphatase and tensin homolog	Homo sapiens	147-151
12013504-0	2002	Pharmacological modulation of carcinoembryonic antigen in human cancer cells: studies with staurosporine.	Staurosporine	91-104	CEA cell adhesion molecule 3	Homo sapiens	30-54
12013504-1	2002	Preliminary studies, performed in our laboratory, showed that staurosporine (ST), a protein-kinase (PK) inhibitor, increases the expression of the carcinoembryonic antigen (CEA) in a human colon cancer cell line.	Staurosporine	62-75	CEA cell adhesion molecule 3	Homo sapiens	147-171
12013504-1	2002	Preliminary studies, performed in our laboratory, showed that staurosporine (ST), a protein-kinase (PK) inhibitor, increases the expression of the carcinoembryonic antigen (CEA) in a human colon cancer cell line.	Staurosporine	62-75	CEA cell adhesion molecule 3	Homo sapiens	173-176
12013504-1	2002	Preliminary studies, performed in our laboratory, showed that staurosporine (ST), a protein-kinase (PK) inhibitor, increases the expression of the carcinoembryonic antigen (CEA) in a human colon cancer cell line.	Staurosporine	77-79	CEA cell adhesion molecule 3	Homo sapiens	147-171
12013504-1	2002	Preliminary studies, performed in our laboratory, showed that staurosporine (ST), a protein-kinase (PK) inhibitor, increases the expression of the carcinoembryonic antigen (CEA) in a human colon cancer cell line.	Staurosporine	77-79	CEA cell adhesion molecule 3	Homo sapiens	173-176
11943195-4	2002	In response to apoptotic stimuli such as staurosporine or hyperosmotic stress, caspase-3 activity was significantly greater in the N63-82Q cells compared to the N63-18Q cells.	Staurosporine	41-54	caspase 3	Homo sapiens	79-88
11950988-5	2002	Using the protein kinase inhibitor staurosporine, we determined that MS up-regulation of TCH3 expression requires protein kinase activity in young Arabidopsis seedlings.	Staurosporine	35-48	Calcium-binding EF hand family protein	Arabidopsis thaliana	89-93
11897097-4	2002	Mitochondria in Ntera2 (NT2 rho+) human teratocarcinoma cells exposed to either staurosporine (STS) or Abeta 25-35 were found to release cytochrome c, with subsequent activation of caspases 9 and 3.	Staurosporine	80-93	cytochrome c, somatic	Homo sapiens	137-149
11897097-4	2002	Mitochondria in Ntera2 (NT2 rho+) human teratocarcinoma cells exposed to either staurosporine (STS) or Abeta 25-35 were found to release cytochrome c, with subsequent activation of caspases 9 and 3.	Staurosporine	80-93	caspase 9	Homo sapiens	181-197
11897097-4	2002	Mitochondria in Ntera2 (NT2 rho+) human teratocarcinoma cells exposed to either staurosporine (STS) or Abeta 25-35 were found to release cytochrome c, with subsequent activation of caspases 9 and 3.	Staurosporine	95-98	cytochrome c, somatic	Homo sapiens	137-149
11897097-4	2002	Mitochondria in Ntera2 (NT2 rho+) human teratocarcinoma cells exposed to either staurosporine (STS) or Abeta 25-35 were found to release cytochrome c, with subsequent activation of caspases 9 and 3.	Staurosporine	95-98	caspase 9	Homo sapiens	181-197
11883953-3	2002	ML-1 cells incubated with either anisomycin or staurosporine exhibited Bax translocation, cytochrome c release, caspase 8 activation, and Bid cleavage; only the latter two events were caspase-dependent, confirming that they are consequences in this apoptotic pathway.	Staurosporine	47-60	BCL2 associated X, apoptosis regulator	Homo sapiens	71-74
11883953-3	2002	ML-1 cells incubated with either anisomycin or staurosporine exhibited Bax translocation, cytochrome c release, caspase 8 activation, and Bid cleavage; only the latter two events were caspase-dependent, confirming that they are consequences in this apoptotic pathway.	Staurosporine	47-60	BH3 interacting domain death agonist	Homo sapiens	138-141
11896617-7	2002	However, approximately 20% of the neuroblastoma cell lines with methylated CASP8 alleles are also highly resistant to staurosporine (STS)- and radiation-induced cell death, presumably because cytochrome c is not released from mitochondria.	Staurosporine	118-131	caspase 8	Homo sapiens	75-80
11896617-7	2002	However, approximately 20% of the neuroblastoma cell lines with methylated CASP8 alleles are also highly resistant to staurosporine (STS)- and radiation-induced cell death, presumably because cytochrome c is not released from mitochondria.	Staurosporine	133-136	caspase 8	Homo sapiens	75-80
12019309-10	2002	Notably, U0126 and a Rsk1 inhibitor (Ro318220) abolished the neuroprotective activity of TGF-beta1 in staurosporine-induced apoptosis, indicating that activation of MAPK is necessary for the antiapoptotic effect of TGF-beta1 in cultured hippocampal cells.	Staurosporine	102-115	ribosomal protein S6 kinase A1	Rattus norvegicus	21-25
12019309-10	2002	Notably, U0126 and a Rsk1 inhibitor (Ro318220) abolished the neuroprotective activity of TGF-beta1 in staurosporine-induced apoptosis, indicating that activation of MAPK is necessary for the antiapoptotic effect of TGF-beta1 in cultured hippocampal cells.	Staurosporine	102-115	transforming growth factor, beta 1	Rattus norvegicus	89-98
12019309-10	2002	Notably, U0126 and a Rsk1 inhibitor (Ro318220) abolished the neuroprotective activity of TGF-beta1 in staurosporine-induced apoptosis, indicating that activation of MAPK is necessary for the antiapoptotic effect of TGF-beta1 in cultured hippocampal cells.	Staurosporine	102-115	mitogen-activated protein kinase 1	Mus musculus	165-169
11883953-3	2002	ML-1 cells incubated with either anisomycin or staurosporine exhibited Bax translocation, cytochrome c release, caspase 8 activation, and Bid cleavage; only the latter two events were caspase-dependent, confirming that they are consequences in this apoptotic pathway.	Staurosporine	47-60	cytochrome c, somatic	Homo sapiens	90-102
11883953-3	2002	ML-1 cells incubated with either anisomycin or staurosporine exhibited Bax translocation, cytochrome c release, caspase 8 activation, and Bid cleavage; only the latter two events were caspase-dependent, confirming that they are consequences in this apoptotic pathway.	Staurosporine	47-60	caspase 8	Homo sapiens	112-121
11751911-5	2002	Protein kinase C (PKC) inhibitors (staurosporine or Ro 31-8220) also inhibited IFN-gamma-induced response.	Staurosporine	35-48	protein kinase C alpha	Homo sapiens	18-21
11751911-5	2002	Protein kinase C (PKC) inhibitors (staurosporine or Ro 31-8220) also inhibited IFN-gamma-induced response.	Staurosporine	35-48	interferon gamma	Homo sapiens	79-88
11953454-5	2002	In contrast, staurosporine treatment of the same cells resulted in activation of multiple caspases and profound apoptotic morphology.	Staurosporine	13-26	caspase 1	Homo sapiens	90-98
11874572-8	2002	In addition, reporter induction and endogenous LOX2 expression by staurosporine was absent in joe2.	Staurosporine	66-79	lipoxygenase 2	Arabidopsis thaliana	47-51
11906323-8	2002	The PKC inhibitor staurosporine blocked cellular contraction to PDBu but not A(23 187) and had no effect on PKC alpha-EGFP translocation.	Staurosporine	18-31	protein kinase C, gamma	Rattus norvegicus	4-7
11744714-7	2002	The inhibitory effects of gp160 were antagonized by staurosporine (0.1 microm), an inhibitor of protein-tyrosine kinases and protein kinase Cs (PKCs), and by Go 6976 (5 microm), an inhibitor acting especially on PKC alpha and PKC beta I.	Staurosporine	52-65	glutamyl aminopeptidase	Homo sapiens	26-31
11802788-1	2002	In the present study, we demonstrate that a human homologue of Ufd2p (a yeast protein that catalyses the formation of long polyubiquitin chains, and is implicated in responses to environmental stress), UFD2 (ubiquitin fusion degradation protein-2), is cleaved during apoptosis induced by multiple stimuli, including UVB irradiation, Fas ligation, staurosporine treatment and cytotoxic lymphocyte granule-induced death.	Staurosporine	347-360	ubiquitination factor E4B	Homo sapiens	63-68
11751911-13	2002	An immunocomplex kinase assay showed that both IFN-gamma and TPA activated c-Src and Lyn activities and that these effects were inhibited by staurosporine and herbimycin.	Staurosporine	141-154	interferon gamma	Homo sapiens	47-56
11751911-13	2002	An immunocomplex kinase assay showed that both IFN-gamma and TPA activated c-Src and Lyn activities and that these effects were inhibited by staurosporine and herbimycin.	Staurosporine	141-154	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	75-80
11751911-13	2002	An immunocomplex kinase assay showed that both IFN-gamma and TPA activated c-Src and Lyn activities and that these effects were inhibited by staurosporine and herbimycin.	Staurosporine	141-154	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	85-88
11909640-10	2002	Staurosporine induced upregulation of p21(WAF-1) whereas p27(Kip1) remained unaltered.	Staurosporine	0-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	38-41
11909640-10	2002	Staurosporine induced upregulation of p21(WAF-1) whereas p27(Kip1) remained unaltered.	Staurosporine	0-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	42-47
11909640-11	2002	P-gp was downregulated upon staurosporine treatment, which was owing to an elevation of intracellular reactive oxygen species by this compound.	Staurosporine	28-41	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
11773703-3	2002	Exposure of neonatal rat cardiomyocytes to the established apoptotic agents, bafilomycin A1 (BAF) or staurosporine (STAU) induced apoptosis and caused a decrease in PP-1 activity of 35%.	Staurosporine	101-114	neuropeptide Y receptor Y4	Rattus norvegicus	165-169
11773703-3	2002	Exposure of neonatal rat cardiomyocytes to the established apoptotic agents, bafilomycin A1 (BAF) or staurosporine (STAU) induced apoptosis and caused a decrease in PP-1 activity of 35%.	Staurosporine	116-120	neuropeptide Y receptor Y4	Rattus norvegicus	165-169
11802788-1	2002	In the present study, we demonstrate that a human homologue of Ufd2p (a yeast protein that catalyses the formation of long polyubiquitin chains, and is implicated in responses to environmental stress), UFD2 (ubiquitin fusion degradation protein-2), is cleaved during apoptosis induced by multiple stimuli, including UVB irradiation, Fas ligation, staurosporine treatment and cytotoxic lymphocyte granule-induced death.	Staurosporine	347-360	ubiquitin-ubiquitin ligase UFD2	Saccharomyces cerevisiae S288C	202-206
11812001-11	2002	However, Mcl-1 expression was reduced by the staurosporine treatment, and this reduction was recovered when the chloride-bicarbonate exchange blocker was added.	Staurosporine	45-58	MCL1 apoptosis regulator, BCL2 family member	Canis lupus familiaris	9-14
11802788-1	2002	In the present study, we demonstrate that a human homologue of Ufd2p (a yeast protein that catalyses the formation of long polyubiquitin chains, and is implicated in responses to environmental stress), UFD2 (ubiquitin fusion degradation protein-2), is cleaved during apoptosis induced by multiple stimuli, including UVB irradiation, Fas ligation, staurosporine treatment and cytotoxic lymphocyte granule-induced death.	Staurosporine	347-360	ubiquitin-ubiquitin ligase UFD2	Saccharomyces cerevisiae S288C	208-246
12022952-9	2002	Intriguingly, HSP70 lacking ABD (HSP70 Delta ABD) inhibits apoptosis induced by serum withdrawal, staurosporin, and menadione, three models of apoptosis which are also affected by micro-injection of anti-AIF antibody or genetic ablation of AIF.	Staurosporine	98-110	heat shock protein 1B	Mus musculus	14-19
11952418-3	2002	In the present study it was shown that apoptosis and release of cytochrome c induced by staurosporine or by tumor necrosis factor-alpha in HeLa cells were not affected by inhibitors of respiration (rotenone, myxothiazol, antimycin A) or by uncouplers (CCCP, DNP) that decrease the membrane potential at the inner mitochondrial membrane.	Staurosporine	88-101	cytochrome c, somatic	Homo sapiens	64-76
12022952-9	2002	Intriguingly, HSP70 lacking ABD (HSP70 Delta ABD) inhibits apoptosis induced by serum withdrawal, staurosporin, and menadione, three models of apoptosis which are also affected by micro-injection of anti-AIF antibody or genetic ablation of AIF.	Staurosporine	98-110	heat shock protein 1B	Mus musculus	33-38
11888106-3	2002	Parathyroid hormone-related protein (1-34) evoked a dose-dependent rescue of both TNFalpha/IFNgamma-induced and staurosporine-induced apoptosis, whereas parathyroid hormone-related protein (67-86) had no significant effect on staurosporine-induced apoptosis, and only significantly diminished TNFalpha/IFNgamma-induced apoptosis at 10 microM.	Staurosporine	112-125	parathyroid hormone like hormone	Homo sapiens	0-35
11830549-0	2002	An MCL1-overexpressing Burkitt lymphoma subline exhibits enhanced survival on exposure to serum deprivation, topoisomerase inhibitors, or staurosporine but remains sensitive to 1-beta-D-arabinofuranosylcytosine.	Staurosporine	138-151	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	3-7
11888106-3	2002	Parathyroid hormone-related protein (1-34) evoked a dose-dependent rescue of both TNFalpha/IFNgamma-induced and staurosporine-induced apoptosis, whereas parathyroid hormone-related protein (67-86) had no significant effect on staurosporine-induced apoptosis, and only significantly diminished TNFalpha/IFNgamma-induced apoptosis at 10 microM.	Staurosporine	226-239	parathyroid hormone like hormone	Homo sapiens	0-35
12214016-2	2002	We investigated this issue, analyzing amyloid beta-protein (A beta) production in a model of neuronal PCD, induced by staurosporine in a murine neuroblastoma cell line.	Staurosporine	118-131	amyloid beta (A4) precursor protein	Mus musculus	60-66
12214016-5	2002	Inhibition of caspases blocked the cleavage at the C-terminus of beta PP, but only partially rescued A beta overproduction caused by staurosporine treatment.	Staurosporine	133-146	amyloid beta (A4) precursor protein	Mus musculus	101-107
11849385-10	2002	Finally, C5a reduced caspase-9 activity in staurosporine-treated cells.	Staurosporine	43-56	complement C5a receptor 1	Homo sapiens	9-12
11834445-5	2002	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the PGE2-induced HSP27 accumulation.	Staurosporine	0-13	heat shock protein 1	Mus musculus	98-103
11849385-10	2002	Finally, C5a reduced caspase-9 activity in staurosporine-treated cells.	Staurosporine	43-56	caspase 9	Homo sapiens	21-30
11926591-9	2002	Interestingly, the increased COX-2 protein and activity in response to VEGF (10 ng/ml) was inhibited by the tyrosine kinase inhibitor, genistein (0.05-5 microg/ml), but not by the protein kinase C inhibitor, staurosporine (0.1-10 ng/ml).	Staurosporine	208-221	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34
11926591-9	2002	Interestingly, the increased COX-2 protein and activity in response to VEGF (10 ng/ml) was inhibited by the tyrosine kinase inhibitor, genistein (0.05-5 microg/ml), but not by the protein kinase C inhibitor, staurosporine (0.1-10 ng/ml).	Staurosporine	208-221	vascular endothelial growth factor A	Homo sapiens	71-75
11896462-8	2002	Finally, in Jurkat T cells stably expressing iAkt, CID-induced Akt activation rescued cells from apoptosis triggered by multiple apoptotic stimuli, including staurosporine, anti-Fas antibodies, PI3K inhibitors and the DNA damaging agent, etoposide.	Staurosporine	158-171	AKT serine/threonine kinase 1	Homo sapiens	46-49
12191604-5	2002	We have determined the crystal structures of staurosporine bound to monomeric CDK2 and UCN-01 bound to active phospho-CDK2/cyclin A.	Staurosporine	45-58	cyclin dependent kinase 2	Homo sapiens	78-82
12191604-5	2002	We have determined the crystal structures of staurosporine bound to monomeric CDK2 and UCN-01 bound to active phospho-CDK2/cyclin A.	Staurosporine	45-58	cyclin dependent kinase 2	Homo sapiens	118-122
12191604-5	2002	We have determined the crystal structures of staurosporine bound to monomeric CDK2 and UCN-01 bound to active phospho-CDK2/cyclin A.	Staurosporine	45-58	cyclin A2	Homo sapiens	123-131
11853409-6	2002	SV and staurosporine-induced cell death was delayed in fibroblasts lacking PARP-1 activity, suggesting that PARP-1 activation contributes to apoptotic cell death induced by these stimuli.	Staurosporine	7-20	poly(ADP-ribose) polymerase 1	Homo sapiens	75-81
11853409-6	2002	SV and staurosporine-induced cell death was delayed in fibroblasts lacking PARP-1 activity, suggesting that PARP-1 activation contributes to apoptotic cell death induced by these stimuli.	Staurosporine	7-20	poly(ADP-ribose) polymerase 1	Homo sapiens	108-114
12579951-9	2002	Pretreatment with 0.1 mmol.L-1 tacrine significantly increased the expression of Bcl-2 protein level and delayed the staurosporine-induced increase of Bax protein expression.	Staurosporine	117-130	BCL2-associated X protein	Mus musculus	151-154
11738249-7	2002	The effects of both PACAP and PMA on Ca(2+) current could be blocked by treating cells with the PKC inhibitor staurosporine.	Staurosporine	110-123	adenylate cyclase activating polypeptide 1	Rattus norvegicus	20-25
11779197-3	2002	Agents that activate Ca(2+)-dependent PKC [phorbol-12-myristate-13-acetate (PMA) and bryostatin 1] increased the level of ER cholesterol; inhibitors such as staurosporine and calphostin C decreased it.	Staurosporine	157-170	protein kinase C delta	Homo sapiens	38-41
11803475-6	2002	PTEN also sensitized cells to non-receptor mediated apoptosis induced by a kinase inhibitor staurosporine and chemotherapeutic agents mitoxantrone and etoposide.	Staurosporine	92-105	phosphatase and tensin homolog	Homo sapiens	0-4
11739114-5	2002	The PMA- and the P-gp inhibitors-induced RVI was abolished by cotreatment with the PKC inhibitors (staurosporine or calphostin C).	Staurosporine	99-112	phosphoglycolate phosphatase	Mus musculus	17-21
12622408-13	2002	Staurosporine induced cell death and activates NF-kappaB.	Staurosporine	0-13	nuclear factor kappa B subunit 1	Homo sapiens	47-56
11849385-3	2002	METHODS: Human neutrophils were isolated and treated with C5a for up to 24 hours, with or without wortmannin, a PI 3-K inhibitor, and staurosporine, a caspase-9 activator.	Staurosporine	134-147	caspase 9	Homo sapiens	151-160
11796751-0	2002	The prevention of the staurosporine-induced apoptosis by Bcl-X(L), but not by Bcl-2 or caspase inhibitors, allows the extensive differentiation of human neuroblastoma cells.	Staurosporine	22-35	BCL2 like 1	Homo sapiens	57-65
11796751-5	2002	Stable over-expression of Bcl-2 in SH-SY5Y protected cells from death at doses of staurosporine up to 1 microm.	Staurosporine	82-95	BCL2 apoptosis regulator	Homo sapiens	26-31
11796751-9	2002	Bcl-X(L) transfected cells showed a remarkable resistance staurosporine-induced cytochrome c release and associated apoptotic changes and survived for up to 15 days in 1 microm staurosporine.	Staurosporine	58-71	BCL2 like 1	Homo sapiens	0-5
11796751-9	2002	Bcl-X(L) transfected cells showed a remarkable resistance staurosporine-induced cytochrome c release and associated apoptotic changes and survived for up to 15 days in 1 microm staurosporine.	Staurosporine	58-71	cytochrome c, somatic	Homo sapiens	80-92
11796751-9	2002	Bcl-X(L) transfected cells showed a remarkable resistance staurosporine-induced cytochrome c release and associated apoptotic changes and survived for up to 15 days in 1 microm staurosporine.	Staurosporine	177-190	BCL2 like 1	Homo sapiens	0-5
12622408-14	2002	Molecular inhibition of NF-kappaB activation with a transdominant negative IkappaB-alpha protected against staurosporine-induced cell death.	Staurosporine	107-120	nuclear factor kappa B subunit 1	Homo sapiens	24-33
12622408-14	2002	Molecular inhibition of NF-kappaB activation with a transdominant negative IkappaB-alpha protected against staurosporine-induced cell death.	Staurosporine	107-120	NFKB inhibitor alpha	Homo sapiens	75-88
11804327-3	2001	Depletion of ALG-2 using an anti-sense ALG-2 construct inhibits apoptosis that is induced by several stimuli, such as staurosporin, dexamethason, Fas, and glucocorticoid.	Staurosporine	118-130	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	13-18
11804327-3	2001	Depletion of ALG-2 using an anti-sense ALG-2 construct inhibits apoptosis that is induced by several stimuli, such as staurosporin, dexamethason, Fas, and glucocorticoid.	Staurosporine	118-130	ALG2 alpha-1,3/1,6-mannosyltransferase	Homo sapiens	39-44
11673456-10	2001	Manipulation of the phosphorylation state of CCK receptor using protein kinase C activation with phorbol ester or inhibition with staurosporine had no effect on the basal level or agonist effect on CCK receptor oligomerization.	Staurosporine	130-143	cholecystokinin	Homo sapiens	45-48
11749967-0	2001	Staurosporine treatment and serum starvation promote the cleavage of emerin in cultured mouse myoblasts: involvement of a caspase-dependent mechanism.	Staurosporine	0-13	emerin	Mus musculus	69-75
11735401-0	2001	Electrophoretic characterization of ribosomal subunits and proteins in apoptosis: specific downregulation of S11 in staurosporine-treated human breast carcinoma cells.	Staurosporine	116-129	surface antigen (X-linked) 2	Homo sapiens	109-112
11749117-7	2001	A significant reduction of amitriptyline-induced vasoconstriction was observed when lungs were treated with the protein kinase inhibitor staurosporine (3 microM, 30 min, p &lt; 0.001), the NO-donor S-nitrosoglutathione (100 microM, 30 min, p &lt; 0.001) and the combined endothelin A/endothelin B receptor antagonist PD 145065.	Staurosporine	137-150	endothelin receptor type B	Homo sapiens	284-305
11749967-0	2001	Staurosporine treatment and serum starvation promote the cleavage of emerin in cultured mouse myoblasts: involvement of a caspase-dependent mechanism.	Staurosporine	0-13	caspase 6	Mus musculus	122-129
11775057-6	2001	We found that the dispersion was decreased by staurosporine and PD98059, which respectively inhibit PKC and MEK, but not by the PKA inhibitor H89.	Staurosporine	46-59	proline rich transmembrane protein 2	Homo sapiens	100-103
11752057-6	2001	Moreover, PS2 overexpression markedly increased neuronal susceptibility to staurosporine-induced apoptosis.	Staurosporine	75-88	presenilin 2	Rattus norvegicus	10-13
11731569-14	2001	The phosphorylated ERK1/ERK2 expression following a hypotonic shock was up-regulated by protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and down-regulated by PKC inhibitor staurosporine.	Staurosporine	195-208	mitogen-activated protein kinase 3	Homo sapiens	19-23
11731569-14	2001	The phosphorylated ERK1/ERK2 expression following a hypotonic shock was up-regulated by protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) and down-regulated by PKC inhibitor staurosporine.	Staurosporine	195-208	mitogen-activated protein kinase 1	Homo sapiens	24-28
11737592-6	2001	HO-1 overexpressing cells were markedly resistant to apoptosis induced by TNFalpha/cycloheximide or staurosporine as assessed by the caspase-3 activity assay.	Staurosporine	100-113	heme oxygenase 1	Sus scrofa	0-4
11803475-12	2002	PTEN facilitated BID cleavage after treatment with low doses of staurosporine and mitoxantrone.	Staurosporine	64-77	phosphatase and tensin homolog	Homo sapiens	0-4
11803475-12	2002	PTEN facilitated BID cleavage after treatment with low doses of staurosporine and mitoxantrone.	Staurosporine	64-77	BH3 interacting domain death agonist	Homo sapiens	17-20
11775057-6	2001	We found that the dispersion was decreased by staurosporine and PD98059, which respectively inhibit PKC and MEK, but not by the PKA inhibitor H89.	Staurosporine	46-59	mitogen-activated protein kinase kinase 7	Homo sapiens	108-111
11479289-4	2001	We found that CaMKLK is a substrate for caspase-3 and -8, both in vitro and in NG108 cells during staurosporine- and serum withdrawal-induced apoptosis.	Staurosporine	98-111	caspase 3	Homo sapiens	40-56
11719451-2	2001	Here we demonstrate that the cytotoxic effect of the protein kinase C (PKC)-inhibitor N-benzoylated staurosporine (PKC412) is mediated via the PI3K/Akt pathway.	Staurosporine	100-113	AKT serine/threonine kinase 1	Homo sapiens	148-151
11719451-6	2001	Comparative experiments indicate that PKC412 and the parent-compound staurosporine down-regulate this survival pathway upstream or at the level of Akt but by a different mechanism than the PI3K-inhibitor LY294002.	Staurosporine	69-82	AKT serine/threonine kinase 1	Homo sapiens	147-150
11767000-3	2001	The PTK inhibitor genistein (GEN) and PKC inhibitor staurosporine (STP) down-regulated Mcl-1 and Bcl-2 expression, and induced growth inhibition by blocking at the G2/M phase of cell cycle, followed by apoptosis, leading to chromatin condensation and DNA fragmentation.	Staurosporine	52-65	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	87-92
11767000-3	2001	The PTK inhibitor genistein (GEN) and PKC inhibitor staurosporine (STP) down-regulated Mcl-1 and Bcl-2 expression, and induced growth inhibition by blocking at the G2/M phase of cell cycle, followed by apoptosis, leading to chromatin condensation and DNA fragmentation.	Staurosporine	52-65	BCL2 apoptosis regulator	Homo sapiens	97-102
11767000-3	2001	The PTK inhibitor genistein (GEN) and PKC inhibitor staurosporine (STP) down-regulated Mcl-1 and Bcl-2 expression, and induced growth inhibition by blocking at the G2/M phase of cell cycle, followed by apoptosis, leading to chromatin condensation and DNA fragmentation.	Staurosporine	67-70	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	87-92
11767000-3	2001	The PTK inhibitor genistein (GEN) and PKC inhibitor staurosporine (STP) down-regulated Mcl-1 and Bcl-2 expression, and induced growth inhibition by blocking at the G2/M phase of cell cycle, followed by apoptosis, leading to chromatin condensation and DNA fragmentation.	Staurosporine	67-70	BCL2 apoptosis regulator	Homo sapiens	97-102
11598088-4	2001	Upon treatment with staurosporine, generation of effector caspase activity, processing of caspase-3 and caspase-9 and cytochrome c redistribution were all profoundly inhibited in cells infected with C. pneumoniae.	Staurosporine	20-33	cytochrome c, somatic	Homo sapiens	118-130
11711494-6	2001	Preincubation of cells with protein kinase inhibitors (staurosporine or Ro 31-8220) enhanced strain-increased PAR-1 expression, whereas inhibitors of NO synthase, tyrosine kinase, and mitogen-activated protein kinases had no effect.	Staurosporine	55-68	coagulation factor II thrombin receptor	Homo sapiens	110-115
11719555-13	2001	To test whether changes in the phosphorylation state of cellular proteins might be responsible for altering the dynamics of ensconsin binding, we used FSM to monitor staurosporine-treated cells.	Staurosporine	166-179	microtubule associated protein 7	Homo sapiens	124-133
11719555-14	2001	Staurosporine treatment substantially halted dynamics of 5xGFP-EMTB speckles along MTs.	Staurosporine	0-13	ribosomal protein S14	Homo sapiens	63-67
11602671-8	2001	Agonist-induced desensitization of the 5-HT2A, but not the 5-HT2C, receptor system was reduced by the PKC inhibitors staurosporine and bisindolylmaleimide, and by down-regulation of PKC.	Staurosporine	117-130	5-hydroxytryptamine receptor 2A	Homo sapiens	39-45
11741532-5	2001	Conversely, staurosporine, which alters kinase domain structure, disrupted receptor binding, even though the catalytic activity of Jak3 is dispensable for receptor binding.	Staurosporine	12-25	Janus kinase 3	Homo sapiens	131-135
11641429-3	2001	Time-lapse confocal microscopy showed that tumor necrosis factor-alpha and staurosporine caused rapid, one- or multiple-step release of cytochrome c-EGFP from mitochondria.	Staurosporine	75-88	cytochrome c, somatic	Homo sapiens	136-148
11718569-15	2001	Although elevated with dexamethasone, staurosporine and hypoxia, these levels were markedly raised in cytotrophoblasts and SGHPL-4 cells following incubations with TNFalpha/IFNgamma.	Staurosporine	38-51	interferon gamma	Homo sapiens	173-181
11600412-7	2001	Incubation with the protein kinase C (PKC) antagonist staurosporine, but not with the fatty acid-binding protein bovine serum albumin, prevented the ET-1-induced decrease in the glutamate uptake.	Staurosporine	54-67	endothelin 1	Rattus norvegicus	149-153
11597902-6	2001	Staurosporine (1 nM), a protein kinase C (PKC) inhibitor, abolished the effect of ET-1.	Staurosporine	0-13	endothelin 1	Homo sapiens	82-86
11489892-3	2001	The release of endogenous cytochrome c from mitochondria into the cytoplasm was detected in Bcl-2-negative cells treated with the kinase inhibitor staurosporine or the calcium-ATPase inhibitor thapsigargin.	Staurosporine	147-160	cytochrome c, somatic	Homo sapiens	26-38
11489892-3	2001	The release of endogenous cytochrome c from mitochondria into the cytoplasm was detected in Bcl-2-negative cells treated with the kinase inhibitor staurosporine or the calcium-ATPase inhibitor thapsigargin.	Staurosporine	147-160	BCL2 apoptosis regulator	Homo sapiens	92-97
11548882-6	2001	IGF-1-mediated ARVM hypertrophy was also attenuated by cyclosporine A (calcineurin inhibitor), and staurosporine and chelerythrine (protein kinase C inhibitors).	Staurosporine	99-112	insulin-like growth factor 1	Rattus norvegicus	0-5
11557554-7	2001	Caspase-3 activation by staurosporine was also ATP dependent.	Staurosporine	24-37	caspase 3	Rattus norvegicus	0-9
11557554-9	2001	Moreover, cyclosporin A, an inhibitor of mitochondrial permeability transition, attenuated staurosporine-induced apoptosis and necrosis through the inhibition of DeltaPsi(m) reduction, cytochrome c release, and caspase-3 activation.	Staurosporine	91-104	caspase 3	Rattus norvegicus	211-220
11568012-5	2001	During spontaneous and staurosporine-induced apoptosis, Bax underwent a caspase-independent translocation to the mitochondria, which was inhibited by IL-5.	Staurosporine	23-36	BCL2 associated X, apoptosis regulator	Homo sapiens	56-59
11568012-5	2001	During spontaneous and staurosporine-induced apoptosis, Bax underwent a caspase-independent translocation to the mitochondria, which was inhibited by IL-5.	Staurosporine	23-36	interleukin 5	Homo sapiens	150-154
11727833-13	2001	Only staurosporin, a broad spectrum inhibitor of protein kinases, and the ionophores monensin and A 23187 effectively inhibited MMP-2 activation in HRSF.	Staurosporine	5-17	matrix metallopeptidase 2	Homo sapiens	128-133
11578598-8	2001	Neuroblastoma cells took up biotinylated Hsc/Hsp70 within 1 h after it was added to the culture medium and it made them more resistant to heat shock (44 degrees C) and to staurosporine-induced apoptosis.	Staurosporine	171-184	fucosyltransferase 1 (H blood group)	Homo sapiens	41-44
11578598-8	2001	Neuroblastoma cells took up biotinylated Hsc/Hsp70 within 1 h after it was added to the culture medium and it made them more resistant to heat shock (44 degrees C) and to staurosporine-induced apoptosis.	Staurosporine	171-184	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
11527420-5	2001	Despite the previous finding that 17-beta-estradiol (10 nM) inhibited the staurosporine-induced binding of p65/p50 NF-kappaB complexes to their cognate DNA elements in cultured rat cardiac myocytes, myocyte extracts showed no change in expression or cellular localization of p65, p50, and IkappaB upon staurosporine or estradiol treatment.	Staurosporine	74-87	synaptotagmin 1	Rattus norvegicus	107-110
11527420-5	2001	Despite the previous finding that 17-beta-estradiol (10 nM) inhibited the staurosporine-induced binding of p65/p50 NF-kappaB complexes to their cognate DNA elements in cultured rat cardiac myocytes, myocyte extracts showed no change in expression or cellular localization of p65, p50, and IkappaB upon staurosporine or estradiol treatment.	Staurosporine	74-87	synaptotagmin 1	Rattus norvegicus	275-278
11527420-5	2001	Despite the previous finding that 17-beta-estradiol (10 nM) inhibited the staurosporine-induced binding of p65/p50 NF-kappaB complexes to their cognate DNA elements in cultured rat cardiac myocytes, myocyte extracts showed no change in expression or cellular localization of p65, p50, and IkappaB upon staurosporine or estradiol treatment.	Staurosporine	302-315	synaptotagmin 1	Rattus norvegicus	107-110
11527420-6	2001	Addition of either estrogen receptor-alpha or estrogen receptor-beta as recombinant protein was sufficient to inhibit staurosporine-dependent p65/p50 DNA binding in cardiac myocytes.	Staurosporine	118-131	estrogen receptor 2	Rattus norvegicus	46-68
11527420-6	2001	Addition of either estrogen receptor-alpha or estrogen receptor-beta as recombinant protein was sufficient to inhibit staurosporine-dependent p65/p50 DNA binding in cardiac myocytes.	Staurosporine	118-131	synaptotagmin 1	Rattus norvegicus	142-145
11527420-7	2001	17-beta-Estradiol inhibits staurosporine-induced p65/p50 DNA binding associated with apoptotic cell death of cardiac myocytes via estrogen receptors-alpha and -beta.	Staurosporine	27-40	synaptotagmin 1	Rattus norvegicus	49-52
11527420-7	2001	17-beta-Estradiol inhibits staurosporine-induced p65/p50 DNA binding associated with apoptotic cell death of cardiac myocytes via estrogen receptors-alpha and -beta.	Staurosporine	27-40	estrogen receptor 2	Rattus norvegicus	130-164
11520805-3	2001	The results of this study show that on death induction by chemotherapeutic drugs, staurosporine and triggering of the death receptor CD95, cytochrome c not only translocates into the cytosol, but furthermore can be abundantly detected in the extracellular medium.	Staurosporine	82-95	cytochrome c, somatic	Homo sapiens	139-151
11683530-11	2001	or zinc plus TGF-beta in elevating bone DNA synthesis activity was significantly inhibited by culture with staurosporine (10(-6) M), an inhibitor of protein kinase C. The present study demonstrates that zinc, like bone growth factors, has a stimulatory effect on bone DNA synthesis in newborn rats.	Staurosporine	107-120	transforming growth factor, beta 1	Rattus norvegicus	13-21
11526446-3	2001	We have found that staurosporine (STS) induces a loss in DeltaPsi(m) before GFP-Bax translocation can be measured.	Staurosporine	34-37	BCL2 associated X, apoptosis regulator	Homo sapiens	76-83
11683585-3	2001	In this regard, we found that the characteristic decrease in IL-1beta production after LPS stimulation could be abrogated by treatment of macrophages with the protein kinase inhibitor staurosporine.	Staurosporine	184-197	interleukin 1 beta	Mus musculus	61-69
11683585-3	2001	In this regard, we found that the characteristic decrease in IL-1beta production after LPS stimulation could be abrogated by treatment of macrophages with the protein kinase inhibitor staurosporine.	Staurosporine	184-197	toll-like receptor 4	Mus musculus	87-90
11683585-6	2001	Staurosporine also mediated an enhancement of LPS-induced IL-1beta promoter activity measured in RAW 264.7 cells transiently transfected with an IL-1beta reporter plasmid.	Staurosporine	0-13	toll-like receptor 4	Mus musculus	46-49
11683585-6	2001	Staurosporine also mediated an enhancement of LPS-induced IL-1beta promoter activity measured in RAW 264.7 cells transiently transfected with an IL-1beta reporter plasmid.	Staurosporine	0-13	interleukin 1 beta	Mus musculus	58-66
11683585-6	2001	Staurosporine also mediated an enhancement of LPS-induced IL-1beta promoter activity measured in RAW 264.7 cells transiently transfected with an IL-1beta reporter plasmid.	Staurosporine	0-13	interleukin 1 beta	Mus musculus	145-153
11683585-7	2001	This increase paralleled the enhancement of IL-1beta mRNA by staurosporine both in intensity and time after LPS stimulation, suggesting that the negative regulation of IL-1beta is exerted primarily at the level of transcription.	Staurosporine	61-74	interleukin 1 beta	Mus musculus	44-52
11683585-7	2001	This increase paralleled the enhancement of IL-1beta mRNA by staurosporine both in intensity and time after LPS stimulation, suggesting that the negative regulation of IL-1beta is exerted primarily at the level of transcription.	Staurosporine	61-74	toll-like receptor 4	Mus musculus	108-111
11683585-7	2001	This increase paralleled the enhancement of IL-1beta mRNA by staurosporine both in intensity and time after LPS stimulation, suggesting that the negative regulation of IL-1beta is exerted primarily at the level of transcription.	Staurosporine	61-74	interleukin 1 beta	Mus musculus	168-176
11683585-8	2001	This regulation may be at least partially due to an observed inhibition of nitric oxide production by staurosporine in LPS-activated macrophages, which was correlated with enhanced IL-1beta production.	Staurosporine	102-115	toll-like receptor 4	Mus musculus	119-122
11683585-8	2001	This regulation may be at least partially due to an observed inhibition of nitric oxide production by staurosporine in LPS-activated macrophages, which was correlated with enhanced IL-1beta production.	Staurosporine	102-115	interleukin 1 beta	Mus musculus	181-189
11587531-0	2001	Human Scythe contains a functional nuclear localization sequence and remains in the nucleus during staurosporine-induced apoptosis.	Staurosporine	99-112	BAG cochaperone 6	Homo sapiens	6-12
11495916-3	2001	The nuclear level of GSK-3 beta was rapidly increased after exposure of cells to serum-free media, heat shock, or staurosporine.	Staurosporine	114-127	glycogen synthase kinase 3 beta	Homo sapiens	21-31
11495916-5	2001	Heat shock and staurosporine treatments increased nuclear GSK-3 beta prior to activation of caspase-9 and caspase-3, and this nuclear accumulation of GSK-3 beta was unaltered by pretreatment with a general caspase inhibitor.	Staurosporine	15-28	glycogen synthase kinase 3 beta	Homo sapiens	58-68
11495916-5	2001	Heat shock and staurosporine treatments increased nuclear GSK-3 beta prior to activation of caspase-9 and caspase-3, and this nuclear accumulation of GSK-3 beta was unaltered by pretreatment with a general caspase inhibitor.	Staurosporine	15-28	caspase 9	Homo sapiens	92-101
11495916-5	2001	Heat shock and staurosporine treatments increased nuclear GSK-3 beta prior to activation of caspase-9 and caspase-3, and this nuclear accumulation of GSK-3 beta was unaltered by pretreatment with a general caspase inhibitor.	Staurosporine	15-28	caspase 3	Homo sapiens	106-115
11495916-5	2001	Heat shock and staurosporine treatments increased nuclear GSK-3 beta prior to activation of caspase-9 and caspase-3, and this nuclear accumulation of GSK-3 beta was unaltered by pretreatment with a general caspase inhibitor.	Staurosporine	15-28	glycogen synthase kinase 3 beta	Homo sapiens	150-160
11570818-4	2001	After induction of apoptosis with staurosporine (Sts), we observed a dramatic increase in the level of PS1-CTF in the medium, both in HEK293 and in primary neurons.	Staurosporine	34-47	presenilin 1	Rattus norvegicus	103-106
11570818-4	2001	After induction of apoptosis with staurosporine (Sts), we observed a dramatic increase in the level of PS1-CTF in the medium, both in HEK293 and in primary neurons.	Staurosporine	49-52	presenilin 1	Rattus norvegicus	103-106
11677261-6	2001	FN, but not DN, stimulation significantly reduced staurosporine-induced caspase-3 activity by 39 +/- 7% at 3 h, 31 +/- 3% at 6 h and 26 +/- 4% at 10 h of incubation.	Staurosporine	50-63	caspase 3	Rattus norvegicus	72-81
11479299-5	2001	The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform.	Staurosporine	29-42	H1.3 linker histone, cluster member	Homo sapiens	169-173
11402024-0	2001	Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin.	Staurosporine	57-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-36
11402024-6	2001	Interestingly, staurosporin and curcumin are also shown to provoke the degradation of ErbB-2 with formation of the 23-kDa carboxyl-terminal fragment.	Staurosporine	15-27	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-92
11402024-8	2001	Caspase inhibition does not prevent accelerated degradation of the 185-kDa native ErbB-2 in geldanamycin-treated cells but does significantly prevent staurosporin-stimulated metabolic loss of ErbB-2.	Staurosporine	150-162	erb-b2 receptor tyrosine kinase 2	Homo sapiens	192-198
11749856-7	2001	Pretreatment of cells with PKC inhibitors Ro-31-8220, staurosporine, and rottlerin increased the propranolol-induced PLD.	Staurosporine	54-67	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	117-120
11570504-12	2001	Pretreatment of staurosporine-induced Jurkat cells with FAM-VAD-FMK inhibited affinity labeling of caspase-3, -6, and -7, blocked caspase-specific cell staining, and led to the inhibition of apoptosis.	Staurosporine	16-29	caspase 3	Homo sapiens	99-120
11520123-0	2001	Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons.	Staurosporine	15-28	catalase	Homo sapiens	134-142
11520123-8	2001	STS treatment for 3-6 h increased cytochrome c release from mitochondria into the cytosol, an effect also blocked by pretreatment with EUK-134.	Staurosporine	0-3	cytochrome c, somatic	Homo sapiens	34-46
11517310-6	2001	Staurosporine treatment induces chromatin condensation, MST1 cleavage, and nuclear translocation.	Staurosporine	0-13	macrophage stimulating 1	Homo sapiens	56-60
11517310-7	2001	Staurosporine-induced chromatin condensation is partially inhibited by expressing a kinase-negative mutant of MST1, suggesting an important role of MST1 in this process.	Staurosporine	0-13	macrophage stimulating 1	Homo sapiens	110-114
11517310-7	2001	Staurosporine-induced chromatin condensation is partially inhibited by expressing a kinase-negative mutant of MST1, suggesting an important role of MST1 in this process.	Staurosporine	0-13	macrophage stimulating 1	Homo sapiens	148-152
11399756-4	2001	Accordingly, we explored whether the well described mitochondrial apoptotic stimuli staurosporine (STS) and etoposide activate Akt and whether such activation impacts apoptosis.	Staurosporine	84-97	thymoma viral proto-oncogene 1	Mus musculus	127-130
11399756-4	2001	Accordingly, we explored whether the well described mitochondrial apoptotic stimuli staurosporine (STS) and etoposide activate Akt and whether such activation impacts apoptosis.	Staurosporine	99-102	thymoma viral proto-oncogene 1	Mus musculus	127-130
11513857-6	2001	However, subsequent exposure of CCCP-treated cells to etoposide or staurosporine for 48 h results in rapid cell death and cytochrome c release that is accompanied by Bax association with mitochondria, demonstrating competency of these mitochondria to release cytochrome c with additional triggers.	Staurosporine	67-80	cytochrome c, somatic	Homo sapiens	122-134
11513857-6	2001	However, subsequent exposure of CCCP-treated cells to etoposide or staurosporine for 48 h results in rapid cell death and cytochrome c release that is accompanied by Bax association with mitochondria, demonstrating competency of these mitochondria to release cytochrome c with additional triggers.	Staurosporine	67-80	BCL2 associated X, apoptosis regulator	Homo sapiens	166-169
11513857-6	2001	However, subsequent exposure of CCCP-treated cells to etoposide or staurosporine for 48 h results in rapid cell death and cytochrome c release that is accompanied by Bax association with mitochondria, demonstrating competency of these mitochondria to release cytochrome c with additional triggers.	Staurosporine	67-80	cytochrome c, somatic	Homo sapiens	259-271
11435215-4	2001	The protein kinase C inhibitors staurosporine (10(-8) mol/l) and calphostin C (10(-7) mol/l) abolished the induction of ET-1 gene expression by CSE in bovine and human PAECs.	Staurosporine	32-45	endothelin 1	Bos taurus	120-124
11487718-3	2001	In the present study subcellular BAX translocations in human colon adenocarcinoma COLO 205 cells exposed to various anticancer drugs [camptothecin (CPT), etoposide (ETO), staurosporine (STP), 2-chloro-2"-deoxyadenosine (2CdA) and nimesulide (NIM)] was examined.	Staurosporine	171-184	BCL2 associated X, apoptosis regulator	Homo sapiens	33-36
11487718-3	2001	In the present study subcellular BAX translocations in human colon adenocarcinoma COLO 205 cells exposed to various anticancer drugs [camptothecin (CPT), etoposide (ETO), staurosporine (STP), 2-chloro-2"-deoxyadenosine (2CdA) and nimesulide (NIM)] was examined.	Staurosporine	186-189	BCL2 associated X, apoptosis regulator	Homo sapiens	33-36
11487718-12	2001	It was shown that BAX Nf increased in cells treated with CPT, STP, ETO, 2CdA and NIM, whereas BAX Cf rose after STP and NIM.	Staurosporine	62-65	BCL2 associated X, apoptosis regulator	Homo sapiens	18-21
11438832-4	2001	The overexpression of Bcl-2 in both cells and the neuronal protection against staurosporine-induced apoptosis were observed, after dual infection of adenoviral vectors with cassette for Bcl-2 (AxCALNLBcl-2) and Cre recombinase (AxCANCre).	Staurosporine	78-91	B cell leukemia/lymphoma 2	Mus musculus	22-27
11431734-5	2001	Down-modulation of Bcl-xL by antisense oligonucleotide activated apoptosis in HepG2 cells in response to cellular stresses induced by staurosporine treatment or by serum starvation.	Staurosporine	134-147	BCL2 like 1	Homo sapiens	19-25
11431734-8	2001	We conclude that Bcl-xL expressed in human HCC cells inhibits apoptosis produced by various cellular stresses, such as staurosporine treatment, serum starvation, and p53 activation, and may play an important role in their survival.	Staurosporine	119-132	BCL2 like 1	Homo sapiens	17-23
11460315-4	2001	Inhibition of tyrosyl phosphorylation of GH receptor-associated tyrosine kinase by tyrphostin-23 or staurosporine blocked GH-stimulated monocyte migration down to random levels.	Staurosporine	100-113	growth hormone receptor	Homo sapiens	41-52
11460315-4	2001	Inhibition of tyrosyl phosphorylation of GH receptor-associated tyrosine kinase by tyrphostin-23 or staurosporine blocked GH-stimulated monocyte migration down to random levels.	Staurosporine	100-113	growth hormone 1	Homo sapiens	41-43
11460315-5	2001	Furthermore, pre-incubation with effective concentrations of 4B-phorbol-12-myristate-13-acetate (PMA), staurosporine and bisindolylmaleimide I, inhibitors of protein kinase C, significantly decreased GH-induced migration, suggesting that PKC is involved in the signalling cascade.	Staurosporine	103-116	growth hormone 1	Homo sapiens	200-202
11450697-4	2001	In contrast to these findings, the stimulatory effects of PTH, TNF-alpha, and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine.	Staurosporine	136-149	parathyroid hormone	Rattus norvegicus	58-61
11450697-4	2001	In contrast to these findings, the stimulatory effects of PTH, TNF-alpha, and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine.	Staurosporine	136-149	tumor necrosis factor	Rattus norvegicus	63-72
11450697-4	2001	In contrast to these findings, the stimulatory effects of PTH, TNF-alpha, and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine.	Staurosporine	136-149	interleukin 1 beta	Rattus norvegicus	78-86
11450697-4	2001	In contrast to these findings, the stimulatory effects of PTH, TNF-alpha, and IL-1beta on the IL-6 promoter expression were enhanced by staurosporine.	Staurosporine	136-149	interleukin 6	Rattus norvegicus	94-98
11450697-7	2001	The findings with staurosporine are consistent with our earlier observations that this agent enhances the calcium signaling and bone resorption elicited by PTH.	Staurosporine	18-31	parathyroid hormone	Rattus norvegicus	156-159
11426445-1	2001	Exposure of rat hippocampal neurons or human D283 medulloblastoma cells to the apoptosis-inducing kinase inhibitor staurosporine induced rapid cytochrome c release from mitochondria and activation of the executioner caspase-3.	Staurosporine	115-128	cytochrome c, somatic	Homo sapiens	143-155
11426445-1	2001	Exposure of rat hippocampal neurons or human D283 medulloblastoma cells to the apoptosis-inducing kinase inhibitor staurosporine induced rapid cytochrome c release from mitochondria and activation of the executioner caspase-3.	Staurosporine	115-128	caspase 3	Homo sapiens	216-225
11426445-3	2001	Overexpression of the anti-apoptotic protein Bcl-xL, but not pharmacological blockade of outward potassium currents, inhibited staurosporine-induced hyperpolarization and apoptosis.	Staurosporine	127-140	BCL2 like 1	Homo sapiens	45-51
11426445-4	2001	Dissipation of mitochondrial potassium and proton gradients by valinomycin or carbonyl cyanide p-trifluoromethoxy-phenylhydrazone also potently inhibited staurosporine-induced hyperpolarization, cytochrome c release, and caspase activation.	Staurosporine	154-167	cytochrome c, somatic	Homo sapiens	195-207
11461967-1	2001	The E2F1 transcription factor modulates neuronal apoptosis induced by staurosporine, DNA damage and beta-amyloid.	Staurosporine	70-83	E2F transcription factor 1	Mus musculus	4-8
11437596-9	2001	Both the Itk(Delta152) deletion mutant and the Itk(P158A,P159A) mutant had IC(50) values similar to those of the wild-type enzyme for staurosporine, PP1, and damnacanthal.	Staurosporine	134-147	IL2 inducible T cell kinase	Homo sapiens	9-12
11437596-9	2001	Both the Itk(Delta152) deletion mutant and the Itk(P158A,P159A) mutant had IC(50) values similar to those of the wild-type enzyme for staurosporine, PP1, and damnacanthal.	Staurosporine	134-147	IL2 inducible T cell kinase	Homo sapiens	47-50
11486239-4	2001	The PKC inhibitors staurosporine and calphostin C inhibited the increase in force/[Ca(2+)]i induced by phenylephrine to a much greater extent than that induced by 80 mM K+.	Staurosporine	19-32	protein kinase C, alpha	Rattus norvegicus	4-7
11463339-8	2001	It was also able to monitor caspase-3 activation in cells provoked into apoptosis by staurosporine (1 or 2 microM).	Staurosporine	85-98	caspase 3	Homo sapiens	28-37
11483406-6	2001	The PGD(2)-stimulated accumulation of HSP27 was reduced by staurosporine or calphostin C, inhibitors of PKC.	Staurosporine	59-72	heat shock protein 1	Mus musculus	38-43
11483407-6	2001	PKC inhibitors (staurosporine, Ro 31-8220, calphostin C, or Go 6976) also inhibited TNF-alpha-induced response.	Staurosporine	16-29	protein kinase C alpha	Homo sapiens	0-3
11483407-6	2001	PKC inhibitors (staurosporine, Ro 31-8220, calphostin C, or Go 6976) also inhibited TNF-alpha-induced response.	Staurosporine	16-29	tumor necrosis factor	Homo sapiens	84-93
11483411-5	2001	The amount of VEGF protein in conditioned media was increased by PMA in a dose-dependent manner with a maximal effect at 10(-7) M. Staurosporine and calphostin C (PKC inhibitors) decreased PMA-induced VEGF mRNA expression as opposed to protein kinase A or cyclic nucleotide-dependent protein kinase inhibitors.	Staurosporine	131-144	vascular endothelial growth factor A	Homo sapiens	14-18
11483411-5	2001	The amount of VEGF protein in conditioned media was increased by PMA in a dose-dependent manner with a maximal effect at 10(-7) M. Staurosporine and calphostin C (PKC inhibitors) decreased PMA-induced VEGF mRNA expression as opposed to protein kinase A or cyclic nucleotide-dependent protein kinase inhibitors.	Staurosporine	131-144	vascular endothelial growth factor A	Homo sapiens	201-205
11526437-0	2001	Staurosporine inhibits phosphorylation of translational regulators linked to mTOR.	Staurosporine	0-13	mechanistic target of rapamycin kinase	Homo sapiens	77-81
11526437-5	2001	Our data show that staurosporine impairs mTOR signalling in vivo but that this not due to direct inhibition of mTOR or to inhibition of protein kinase C. It is becoming clear that agents which cause apoptosis inactivate mTOR signalling as a common early response prior to the execution of apoptosis, i.e., before caspase activation.	Staurosporine	19-32	mechanistic target of rapamycin kinase	Homo sapiens	41-45
11483662-6	2001	The effect of lead on DNA synthesis was mediated through PKC as evidenced by the finding that two PKC inhibitors, GF 109203X and staurosporine, as well as down-regulation of PKC through prolonged treatment with 12-O-tetradecanoylphorbol 13-acetate, blocked lead-induced DNA synthesis.	Staurosporine	129-142	proline rich transmembrane protein 2	Homo sapiens	57-60
11448162-4	2001	In such cells the PKC inhibitors 1-(5-isoquinolinesulphonyl)-2,5-dimethylpiperazine (H7) and staurosporine inhibited TPA-induced expression of BZLF1 and BRLF1 and reversed TPA-mediated inhibition of iNOS gene expression.	Staurosporine	93-106	protein Zta	Human gammaherpesvirus 4	143-148
11448162-4	2001	In such cells the PKC inhibitors 1-(5-isoquinolinesulphonyl)-2,5-dimethylpiperazine (H7) and staurosporine inhibited TPA-induced expression of BZLF1 and BRLF1 and reversed TPA-mediated inhibition of iNOS gene expression.	Staurosporine	93-106	nitric oxide synthase 2	Homo sapiens	199-203
11373274-4	2001	We found that staurosporine, a broad-specificity kinase inhibitor and inducer of cell apoptosis, attenuated PKB activation exclusively through the inhibition of Thr-308 phosphorylation, with Ser-473 phosphorylation unaffected.	Staurosporine	14-27	protein tyrosine kinase 2 beta	Homo sapiens	108-111
11373274-5	2001	The increase in Thr-308 phosphorylation because of overexpression of PDK1 was also inhibited by staurosporine.	Staurosporine	96-109	3-phosphoinositide dependent protein kinase 1	Homo sapiens	69-73
11373274-6	2001	We further show that staurosporine (CGP 39360) potently inhibited PDK1 activity in vitro with an IC(50) of approximately 0.22 microm.	Staurosporine	21-34	3-phosphoinositide dependent protein kinase 1	Homo sapiens	66-70
11373274-8	2001	Moreover, our results suggest that inhibition of PKB signaling is involved in the proapoptotic action of staurosporine.	Staurosporine	105-118	protein tyrosine kinase 2 beta	Homo sapiens	49-52
11422221-7	2001	The protein kinase C (PKC) inhibitors staurosporine (10-8 mol/L) and calphostin C (10-7 mol/L) markedly attenuated the ET-1-induced enhancement of NA responses.	Staurosporine	38-51	endothelin 1	Rattus norvegicus	119-123
11422221-11	2001	In the presence of both staurosporine and Y-27632, contractile responses to NA alone were decreased markedly and ET-1-induced potentiation was abolished.	Staurosporine	24-37	endothelin 1	Rattus norvegicus	113-117
11414705-3	2001	TRAIL-resistant cells were sensitized to TRAIL-induced apoptosis by staurosporine pretreatment and preferentially expressed PKCepsilon.	Staurosporine	68-81	TNF superfamily member 10	Homo sapiens	0-5
11414705-3	2001	TRAIL-resistant cells were sensitized to TRAIL-induced apoptosis by staurosporine pretreatment and preferentially expressed PKCepsilon.	Staurosporine	68-81	TNF superfamily member 10	Homo sapiens	41-46
11312266-7	2001	Finally, we show that p75NTR expression increased survival in cells exposed to staurosporine or subjected to serum withdrawal.	Staurosporine	79-92	nerve growth factor receptor	Homo sapiens	22-28
11368523-0	2001	Prevention of staurosporine-induced cell death in embryonic chick cardiomyocyte is more dependent on caspase-2 than caspase-3 inhibition and is independent of sphingomyelinase activation and ceramide generation.	Staurosporine	14-27	caspase 2	Gallus gallus	101-110
11488451-8	2001	Staurosporine, a broad spectrum PKC inhibitor, was found to inhibit both spontaneous and euxanthone-induced neuritogenesis in BU-1 cells.	Staurosporine	0-13	protein kinase C, alpha	Mus musculus	32-35
11395610-13	2001	Protein kinase C inhibitors, chelerythrine and staurosporine, decreased the constrictor response to endothelin-1.	Staurosporine	47-60	endothelin 1	Homo sapiens	100-112
11278283-6	2001	Staurosporine activates MST either caspase-dependently or independently, whereas Fas ligation activates it only caspase-dependently.	Staurosporine	0-13	mitogen-activated protein kinase kinase kinase 10	Homo sapiens	24-27
16120269-5	2001	Caspase activation took place predominantly in the cytosol in response to Fas ligation, but staurosporine treatment led to caspase activation in both cytosol and mitochondria.	Staurosporine	92-105	caspase 2	Homo sapiens	123-130
16120269-6	2001	In response to both Fas and staurosporine treatment, caspase processing could be detected earlier in cytosol than in mitochondria, but this could reflect the limits of sensitive detection by immunoblotting.	Staurosporine	28-41	caspase 2	Homo sapiens	53-60
16120269-8	2001	However, staurosporine treatment led to preferential auto-processing of caspase-9 associated with mitochondria.	Staurosporine	9-22	caspase 9	Homo sapiens	72-81
16120269-11	2001	Using a stable transfected CEM cell line, we show that Bcl-2 suppressed caspase processing in both cytosolic and mitochondrial compartments in response to both staurosporine and Fas ligation.	Staurosporine	160-173	BCL2 apoptosis regulator	Homo sapiens	55-60
11336639-4	2001	We now report that the effect of [K44A]dynamin on EGF binding was counteracted by incubation with the non-specific kinase inhibitor staurosporine (SSP), implying that a protein kinase is responsible for disrupted high-affinity binding of EGF upon overexpression of [K44A]dynamin.	Staurosporine	132-145	epidermal growth factor	Homo sapiens	50-53
11336639-4	2001	We now report that the effect of [K44A]dynamin on EGF binding was counteracted by incubation with the non-specific kinase inhibitor staurosporine (SSP), implying that a protein kinase is responsible for disrupted high-affinity binding of EGF upon overexpression of [K44A]dynamin.	Staurosporine	132-145	epidermal growth factor	Homo sapiens	238-241
11336639-4	2001	We now report that the effect of [K44A]dynamin on EGF binding was counteracted by incubation with the non-specific kinase inhibitor staurosporine (SSP), implying that a protein kinase is responsible for disrupted high-affinity binding of EGF upon overexpression of [K44A]dynamin.	Staurosporine	147-150	epidermal growth factor	Homo sapiens	50-53
11336639-4	2001	We now report that the effect of [K44A]dynamin on EGF binding was counteracted by incubation with the non-specific kinase inhibitor staurosporine (SSP), implying that a protein kinase is responsible for disrupted high-affinity binding of EGF upon overexpression of [K44A]dynamin.	Staurosporine	147-150	epidermal growth factor	Homo sapiens	238-241
11342415-5	2001	Both CXCR4 and CCR5 were desensitized by activation of the cells with WKYMVm via a staurosporine-sensitive pathway.	Staurosporine	83-96	C-X-C motif chemokine receptor 4	Homo sapiens	5-10
11342415-5	2001	Both CXCR4 and CCR5 were desensitized by activation of the cells with WKYMVm via a staurosporine-sensitive pathway.	Staurosporine	83-96	C-C motif chemokine receptor 5	Homo sapiens	15-19
11369496-2	2001	In this study, we determined the effect of RA on the mRNA and protein levels of the Cu-,Zn-superoxide dismutase (SOD-1) and Mn-superoxide dismutase (SOD-2) during staurosporine-induced apoptosis in primary cultures from neonatal rat hippocampus.	Staurosporine	163-176	superoxide dismutase 1	Rattus norvegicus	113-118
11369496-2	2001	In this study, we determined the effect of RA on the mRNA and protein levels of the Cu-,Zn-superoxide dismutase (SOD-1) and Mn-superoxide dismutase (SOD-2) during staurosporine-induced apoptosis in primary cultures from neonatal rat hippocampus.	Staurosporine	163-176	superoxide dismutase 2	Rattus norvegicus	149-154
11369496-6	2001	However, the SOD-1 and SOD-2 protein levels markedly decreased 24 and 48 h after the addition of staurosporine.	Staurosporine	97-110	superoxide dismutase 1	Rattus norvegicus	13-18
11369496-6	2001	However, the SOD-1 and SOD-2 protein levels markedly decreased 24 and 48 h after the addition of staurosporine.	Staurosporine	97-110	superoxide dismutase 2	Rattus norvegicus	23-28
11369496-8	2001	The results suggest that RA reduced staurosporine-induced oxidative stress and apoptosis by preventing the decrease in the protein levels of SOD-1 and SOD-2, and thus supported the antioxidant defense system.	Staurosporine	36-49	superoxide dismutase 1	Rattus norvegicus	141-146
11369496-8	2001	The results suggest that RA reduced staurosporine-induced oxidative stress and apoptosis by preventing the decrease in the protein levels of SOD-1 and SOD-2, and thus supported the antioxidant defense system.	Staurosporine	36-49	superoxide dismutase 2	Rattus norvegicus	151-156
11278782-1	2001	The serine/threonine kinase Mst1, a mammalian homolog of the budding yeast Ste20 kinase, is cleaved by caspase-mediated proteolysis in response to apoptotic stimuli such as ligation of CD95/Fas or treatment with staurosporine.	Staurosporine	212-225	macrophage stimulating 1	Homo sapiens	28-32
11278782-1	2001	The serine/threonine kinase Mst1, a mammalian homolog of the budding yeast Ste20 kinase, is cleaved by caspase-mediated proteolysis in response to apoptotic stimuli such as ligation of CD95/Fas or treatment with staurosporine.	Staurosporine	212-225	Fas cell surface death receptor	Homo sapiens	185-189
11327694-3	2001	When pretreated with TGF-beta1 for 1-2 h, L929 cells resisted staurosporine apoptosis.	Staurosporine	62-75	transforming growth factor, beta 1	Mus musculus	21-30
11327694-6	2001	Nonetheless, TGF-beta1 synergistically increased hyaluronidase-mediated inhibition of staurosporine apoptosis.	Staurosporine	86-99	transforming growth factor, beta 1	Mus musculus	13-22
11327694-8	2001	Dominant negative JNK1, JNK2, and JNK3 abolished the hyaluronidase inhibition of staurosporine apoptosis, but not the TGF-beta1 protective effect.	Staurosporine	81-94	mitogen-activated protein kinase 8	Mus musculus	18-22
11327694-8	2001	Dominant negative JNK1, JNK2, and JNK3 abolished the hyaluronidase inhibition of staurosporine apoptosis, but not the TGF-beta1 protective effect.	Staurosporine	81-94	mitogen-activated protein kinase 10	Mus musculus	34-38
11294760-6	2001	The cytoprotective effect of ET-1 was abolished by pretreatment with cycloheximide or staurosporine.	Staurosporine	86-99	endothelin 1	Rattus norvegicus	29-33
11369000-8	2001	In contrast the nonspecific protein kinase inhibitor staurosporin completely inhibited cPLA(2) activity.	Staurosporine	53-65	phospholipase A2 group IVA	Homo sapiens	87-94
11369514-5	2001	Staurosporine [protein kinase-C (PK-C) inhibitor] and PD98059 [mitogen-activated protein kinase inhibitor (MAPK)] only partially inhibited GHA-induced TNF-alpha.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	15-31
11369514-5	2001	Staurosporine [protein kinase-C (PK-C) inhibitor] and PD98059 [mitogen-activated protein kinase inhibitor (MAPK)] only partially inhibited GHA-induced TNF-alpha.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	33-37
11369514-5	2001	Staurosporine [protein kinase-C (PK-C) inhibitor] and PD98059 [mitogen-activated protein kinase inhibitor (MAPK)] only partially inhibited GHA-induced TNF-alpha.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	151-160
11465111-4	2001	The phorbol 12-myristate 13-acetate-augmented expression of CD28 on these cells can be blocked by actinomycin D, an RNA transcription inhibitor, and staurosporin, a protein kinase inhibitor.	Staurosporine	149-161	CD28 molecule	Homo sapiens	60-64
11368523-0	2001	Prevention of staurosporine-induced cell death in embryonic chick cardiomyocyte is more dependent on caspase-2 than caspase-3 inhibition and is independent of sphingomyelinase activation and ceramide generation.	Staurosporine	14-27	caspase 3	Gallus gallus	116-125
11368523-4	2001	The combination of the caspase-3 and -2 inhibitors produced an additive reduction in cell death after staurosporine (1 microM for 6 h) from 80.4 +/- 0.7 to 54.6 +/- 1.3%.	Staurosporine	102-115	caspase 3	Gallus gallus	23-39
11368523-5	2001	The ability of staurosporine to activate caspase-3 was confirmed in these cardiomyocytes by measurement of caspase-3 activity.	Staurosporine	15-28	caspase 3	Gallus gallus	41-50
11368523-5	2001	The ability of staurosporine to activate caspase-3 was confirmed in these cardiomyocytes by measurement of caspase-3 activity.	Staurosporine	15-28	caspase 3	Gallus gallus	107-116
11309196-3	2001	Induction of apoptosis by staurosporine or MG132 and oxidative stress by H(2)O(2) or FeCN enhanced the nuclear translocation of endogenous GAPDH in all cell types, as detected by immunocytochemistry.	Staurosporine	26-39	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	139-144
11374539-4	2001	When cells were cultured with H-89 (10 microM), GF109203X (10 microM), or staurosporine (100 nM), inhibitors of protein kinase A, protein kinase C, and Janus kinase (JAK) 2, respectively, the inhibitory effect of ST on FAS mRNA levels was not altered.	Staurosporine	74-87	Janus kinase 2	Homo sapiens	152-172
11312156-4	2001	PMA is known to specifically activate protein kinase C and, indeed, the stimulatory effects of PMA in both cell lines were completely inhibited by the protein kinase inhibitor, staurosporine (100 nM), suggesting that activation of protein kinase C (PKC) may mediate PMA-induced GHBP shedding.	Staurosporine	177-190	growth hormone receptor	Homo sapiens	278-282
11358994-6	2001	Moreover, cannabinol-mediated enhancement of IL-2 secretion by splenocytes was attenuated to various degrees by staurosporine, Ro-31-8220, and KN93.	Staurosporine	112-125	interleukin 2	Mus musculus	45-49
11351088-6	2001	Staurosporine, a protein kinase inhibitor, on the other hand, inhibited the OA-induced Phal-ACS1 expression in the stigma and delayed flower senescence.	Staurosporine	0-13	acyl-CoA synthetase long chain family member 1	Homo sapiens	92-96
11337282-10	2001	Additionally, pretreatment of LNCaP cells with staurosporine, a potent inhibitor of several isozymes of the PKC family, inhibited apoptosis in these cells and completely blocked activation of Rb and repression of c-myc.	Staurosporine	47-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	213-218
11278328-5	2001	In both rapsyn-deficient myotubes and staurosporine-treated C2 myotubes, where AChRs are not clustered, agrin activated MuSK but did not cause either Src family or AChR phosphorylation.	Staurosporine	38-51	agrin	Homo sapiens	104-109
11278328-5	2001	In both rapsyn-deficient myotubes and staurosporine-treated C2 myotubes, where AChRs are not clustered, agrin activated MuSK but did not cause either Src family or AChR phosphorylation.	Staurosporine	38-51	muscle associated receptor tyrosine kinase	Homo sapiens	120-124
11322947-8	2001	The Livin alpha but not beta protects cells from apoptosis induced by staurosporine, but in contrast, apoptosis initiated by etoposide was blocked only by the beta isoform.	Staurosporine	70-83	baculoviral IAP repeat containing 7	Homo sapiens	4-9
11136736-3	2001	After treatment of the HeLa cells with the apoptosis inducer staurosporine or UV irradiation, Bax associated with mitochondria is present as two large molecular weight oligomers/complexes of 96,000 and 260,000 Da, which are integrated into the mitochondrial membrane.	Staurosporine	61-74	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
11278345-5	2001	Synaptosomal phosphorylation of NSF is stimulated by phorbol esters and is inhibited by staurosporine, chelerythrine, bisindolylmaleimide I, calphostin C, and Ro31-8220 but not the calmodulin kinase II inhibitor, Kn-93, suggesting a role for protein kinase C (PKC).	Staurosporine	88-101	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Rattus norvegicus	32-35
11245599-3	2001	We show that NIH/3T3 cells harboring antisense caveolin-1 are resistant to staurosporine-induced apoptosis, as assessed using cell morphology, DNA content, caspase 3 activation, and focal adhesion kinase cleavage.	Staurosporine	75-88	caveolin 1, caveolae protein	Mus musculus	47-57
11425486-3	2001	Depending on their concentrations, GO and MGO promoted phosphorylations of ERK1 and ERK2, which were blocked by the protein-tyrosine kinase (PTK) inhibitors herbimycin A and staurosporine, thereby being PTK-dependent.	Staurosporine	174-187	mitogen-activated protein kinase 3	Homo sapiens	75-79
11425486-3	2001	Depending on their concentrations, GO and MGO promoted phosphorylations of ERK1 and ERK2, which were blocked by the protein-tyrosine kinase (PTK) inhibitors herbimycin A and staurosporine, thereby being PTK-dependent.	Staurosporine	174-187	mitogen-activated protein kinase 1	Homo sapiens	84-88
11425486-3	2001	Depending on their concentrations, GO and MGO promoted phosphorylations of ERK1 and ERK2, which were blocked by the protein-tyrosine kinase (PTK) inhibitors herbimycin A and staurosporine, thereby being PTK-dependent.	Staurosporine	174-187	EPH receptor A8	Homo sapiens	116-139
11425486-3	2001	Depending on their concentrations, GO and MGO promoted phosphorylations of ERK1 and ERK2, which were blocked by the protein-tyrosine kinase (PTK) inhibitors herbimycin A and staurosporine, thereby being PTK-dependent.	Staurosporine	174-187	EPH receptor A8	Homo sapiens	141-144
11425486-3	2001	Depending on their concentrations, GO and MGO promoted phosphorylations of ERK1 and ERK2, which were blocked by the protein-tyrosine kinase (PTK) inhibitors herbimycin A and staurosporine, thereby being PTK-dependent.	Staurosporine	174-187	EPH receptor A8	Homo sapiens	203-206
11264247-11	2001	Pretreatment with PMA for 24 h, preincubation with a PKC inhibitor staurosporine or the tyrosine kinase inhibitors, genistein and herbimycin A for 1 h, substantially reduced [(3)H]-thymidine incorporation and p42/p44 MAPK phosphorylation induced by OX-LDL.	Staurosporine	67-80	mitogen activated protein kinase 3	Rattus norvegicus	213-221
11550085-3	2001	Using these antisera and caspase-9- and caspase-3-deficient mouse embryonic fibroblasts, we demonstrated that mouse caspase-9 is initially autoprocessed at D(353) and D(368) at low levels during staurosporine-induced apoptosis, whereupon the D(368) and D(168) sites are preferentially processed over D(353) by activated caspase-3 as part of a feedback amplification loop.	Staurosporine	195-208	caspase 9	Mus musculus	116-125
11277940-4	2001	The reduction in guanylate cyclase C mRNA was inhibited when cells were treated with 4beta-phorbol 12-myristate 13-acetate (PMA) in the presence of staurosporine, indicating that a primary phosphorylation event by protein kinase C triggered the reduction in RNA levels.	Staurosporine	148-161	natriuretic peptide receptor 3	Homo sapiens	17-36
11254687-12	2001	Finally, we show that staurosporine, a serine kinase inhibitor, enhances the membrane cleavage of CD100.	Staurosporine	22-35	semaphorin 4D	Homo sapiens	98-103
11259569-12	2001	Conversely, in the presence of the protein kinase inhibitors H-8 and staurosporine, ADn neurons still expressed a 5-HT-induced shift in the voltage dependence of I(h).	Staurosporine	69-82	complement factor D	Homo sapiens	84-87
11523308-1	2001	Staurosporine, a selective inhibitor of protein kinase C (PKC) in the low nanomolar range suppresses superoxide production from polymorphonuclear leukocytes (PMNs).	Staurosporine	0-13	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	40-54
11259672-2	2001	We have shown that the hbrm protein is cleaved in NB4 leukemic cells after induction of apoptosis by UV-irradiation, DNA damaging agents, or staurosporine.	Staurosporine	141-154	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Homo sapiens	23-27
11124948-4	2001	Although the broad-spectrum kinase inhibitor staurosporine potently blocked IRF3 and -7 phosphorylation, inhibitors for protein kinase C, protein kinase A, MEK, SAPK, IKK, and protein kinase R (PKR) were without effect.	Staurosporine	45-58	interferon regulatory factor 3	Homo sapiens	76-80
11124948-4	2001	Although the broad-spectrum kinase inhibitor staurosporine potently blocked IRF3 and -7 phosphorylation, inhibitors for protein kinase C, protein kinase A, MEK, SAPK, IKK, and protein kinase R (PKR) were without effect.	Staurosporine	45-58	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	194-197
11313863-2	2001	It is generally believed that the molecular events during execution of apoptosis are shared, as both anticancer drugs and staurosporine derivatives induce mitochondrial damage, cytochrome c release and the activation of the caspase-9 proteolytic cascade.	Staurosporine	122-135	cytochrome c, somatic	Homo sapiens	177-189
11313863-2	2001	It is generally believed that the molecular events during execution of apoptosis are shared, as both anticancer drugs and staurosporine derivatives induce mitochondrial damage, cytochrome c release and the activation of the caspase-9 proteolytic cascade.	Staurosporine	122-135	caspase 9	Homo sapiens	224-233
11396181-0	2001	Complex regulation of CDK2 and G1 arrest during neuronal differentiation of human prostatic cancer TSU-Prl cells by staurosporine.	Staurosporine	116-129	cyclin dependent kinase 2	Homo sapiens	22-26
11396181-4	2001	Treatment of TSU-Pr1 cells with staurosporine resulted in G1 arrest and suppression of CDK2 activity.	Staurosporine	32-45	cyclin dependent kinase 2	Homo sapiens	87-91
11396181-6	2001	p21 protein, however, rapidly increased for 6 hours after treatment with staurosporine.	Staurosporine	73-86	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
11396181-10	2001	We propose that the complex regulation of CDK2 plays a key role in G1 arrest of TSU-Pr1 cells after treatment with staurosporine.	Staurosporine	115-128	cyclin dependent kinase 2	Homo sapiens	42-46
11226140-4	2001	We have found that DHPG-induced LTD is resistant to the two potent protein kinase C (PKC) inhibitors, Go 6976 (10 microM) and Go 6983 (10 microM), the potent and selective protein kinase A (PKA) inhibitor, KT 5720 (10 microM), and the potent broad spectrum kinase inhibitor, staurosporine (10 microM).	Staurosporine	275-288	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	190-193
11319614-4	2001	K15 and K17 proteolysis was observed during staurosporine-induced apoptosis and anoikis (anchorage-dependent apoptosis) as well and was shown to be caspase-dependent.	Staurosporine	44-57	keratin 15	Homo sapiens	0-3
11319614-4	2001	K15 and K17 proteolysis was observed during staurosporine-induced apoptosis and anoikis (anchorage-dependent apoptosis) as well and was shown to be caspase-dependent.	Staurosporine	44-57	keratin 17	Homo sapiens	8-11
11231287-10	2001	Bcl-2 expression was strongly increased by PMA and drastically decreased by staurosporine as was Bcl-x(L) expression.	Staurosporine	76-89	BCL2 apoptosis regulator	Homo sapiens	0-5
11282556-6	2001	Staurosporine, but not the anti-Fas antibody CH11, abrogates constitutive Hsp70 expression at 37 degrees C and staurosporine also inhibit Hsp27 expression in Jd and Jr cells at 42 degrees C. These data suggest that constitutive expression of Hsp27 inhibits Fas-mediated apoptosis, but only induced expression of Hsp70 can protect T cells from staurosporine-induced apoptosis.	Staurosporine	0-13	heat shock protein family A (Hsp70) member 4	Homo sapiens	74-79
11282556-6	2001	Staurosporine, but not the anti-Fas antibody CH11, abrogates constitutive Hsp70 expression at 37 degrees C and staurosporine also inhibit Hsp27 expression in Jd and Jr cells at 42 degrees C. These data suggest that constitutive expression of Hsp27 inhibits Fas-mediated apoptosis, but only induced expression of Hsp70 can protect T cells from staurosporine-induced apoptosis.	Staurosporine	0-13	heat shock protein family B (small) member 1	Homo sapiens	242-247
11282556-6	2001	Staurosporine, but not the anti-Fas antibody CH11, abrogates constitutive Hsp70 expression at 37 degrees C and staurosporine also inhibit Hsp27 expression in Jd and Jr cells at 42 degrees C. These data suggest that constitutive expression of Hsp27 inhibits Fas-mediated apoptosis, but only induced expression of Hsp70 can protect T cells from staurosporine-induced apoptosis.	Staurosporine	0-13	heat shock protein family A (Hsp70) member 4	Homo sapiens	312-317
11282556-6	2001	Staurosporine, but not the anti-Fas antibody CH11, abrogates constitutive Hsp70 expression at 37 degrees C and staurosporine also inhibit Hsp27 expression in Jd and Jr cells at 42 degrees C. These data suggest that constitutive expression of Hsp27 inhibits Fas-mediated apoptosis, but only induced expression of Hsp70 can protect T cells from staurosporine-induced apoptosis.	Staurosporine	111-124	heat shock protein family B (small) member 1	Homo sapiens	138-143
11282556-6	2001	Staurosporine, but not the anti-Fas antibody CH11, abrogates constitutive Hsp70 expression at 37 degrees C and staurosporine also inhibit Hsp27 expression in Jd and Jr cells at 42 degrees C. These data suggest that constitutive expression of Hsp27 inhibits Fas-mediated apoptosis, but only induced expression of Hsp70 can protect T cells from staurosporine-induced apoptosis.	Staurosporine	111-124	heat shock protein family B (small) member 1	Homo sapiens	242-247
11282556-6	2001	Staurosporine, but not the anti-Fas antibody CH11, abrogates constitutive Hsp70 expression at 37 degrees C and staurosporine also inhibit Hsp27 expression in Jd and Jr cells at 42 degrees C. These data suggest that constitutive expression of Hsp27 inhibits Fas-mediated apoptosis, but only induced expression of Hsp70 can protect T cells from staurosporine-induced apoptosis.	Staurosporine	111-124	heat shock protein family A (Hsp70) member 4	Homo sapiens	312-317
11354246-0	2001	Effects of staurosporine, U-73122, wortmannin, 4-hydroxynonenal and sodium azide upon the release of secreted beta-amyloid precursor protein from human platelets in response to thrombin stimulation.	Staurosporine	11-24	amyloid beta precursor protein	Homo sapiens	110-140
11099781-2	2001	The present study attempted to identify whether TGF-beta1 can prevent neuronal apoptosis and interrupt caspase-3 activation in rat primary hippocampal cultures after staurosporine treatment.	Staurosporine	166-179	transforming growth factor, beta 1	Rattus norvegicus	48-57
11099781-2	2001	The present study attempted to identify whether TGF-beta1 can prevent neuronal apoptosis and interrupt caspase-3 activation in rat primary hippocampal cultures after staurosporine treatment.	Staurosporine	166-179	caspase 3	Rattus norvegicus	103-112
11099781-4	2001	Nuclear staining with Hoechst 33258 and TUNEL-staining further demonstrated that TGF-beta1 at the same concentration range effectively diminished neuronal apoptosis 24 h after staurosporine treatment, whereas 0.1 ng/ml of TGF-beta1 did not.	Staurosporine	176-189	transforming growth factor, beta 1	Rattus norvegicus	81-90
11099781-5	2001	Furthermore, TGF-beta1 (1 and 10 ng/ml) markedly inhibited the activation of caspase-3 induced by staurosporine as demonstrated by both caspase-3 activity assay and Western blotting.	Staurosporine	98-111	transforming growth factor, beta 1	Rattus norvegicus	13-22
11099781-5	2001	Furthermore, TGF-beta1 (1 and 10 ng/ml) markedly inhibited the activation of caspase-3 induced by staurosporine as demonstrated by both caspase-3 activity assay and Western blotting.	Staurosporine	98-111	caspase 3	Rattus norvegicus	77-86
11099781-5	2001	Furthermore, TGF-beta1 (1 and 10 ng/ml) markedly inhibited the activation of caspase-3 induced by staurosporine as demonstrated by both caspase-3 activity assay and Western blotting.	Staurosporine	98-111	caspase 3	Rattus norvegicus	136-145
11161717-5	2001	SP-A protected primary cultures of rat type II alveolar cells against the apoptotic effects of etoposide and UV light and also protected the H441 human Clara lung tumor cell line against staurosporine-induced apoptosis.	Staurosporine	187-200	surfactant protein A1	Rattus norvegicus	0-4
11253165-7	2001	The inhibitory effect of AVP on the apoptosis was reduced by staurosporine and mimicked by phorbol-12-myristate-13-acetate.	Staurosporine	61-74	arginine vasopressin	Rattus norvegicus	25-28
11381362-8	2001	Our data show that (1) human colon cancer cells downregulate caspase 7 and, to a smaller extent, caspase 9 in vivo and (2) in vitro staurosporine-induced apoptosis of colonic cancer cells involves caspases 7 and 9.	Staurosporine	132-145	caspase 7	Homo sapiens	61-70
11381362-8	2001	Our data show that (1) human colon cancer cells downregulate caspase 7 and, to a smaller extent, caspase 9 in vivo and (2) in vitro staurosporine-induced apoptosis of colonic cancer cells involves caspases 7 and 9.	Staurosporine	132-145	caspase 9	Homo sapiens	97-106
11381362-8	2001	Our data show that (1) human colon cancer cells downregulate caspase 7 and, to a smaller extent, caspase 9 in vivo and (2) in vitro staurosporine-induced apoptosis of colonic cancer cells involves caspases 7 and 9.	Staurosporine	132-145	caspase 7	Homo sapiens	197-213
11245486-0	2001	Overexpression of BCL-X(L) underlies the molecular basis for resistance to staurosporine-induced apoptosis in PC-3 cells.	Staurosporine	75-88	BCL2 like 1	Homo sapiens	18-26
11058590-4	2001	Induction of mitochondrial permeability transition by TNF, staurosporine, and atractyloside resulted in WOX1 release from mitochondria and subsequent nuclear translocation.	Staurosporine	59-72	WW domain-containing oxidoreductase	Mus musculus	104-108
11180512-6	2001	IFN-gamma treatment protects astrocytic cells from apoptosis resulting from FCS deprivation, heat-shock, or staurosporine treatment, as well as increases p21 binding of GTP.	Staurosporine	108-121	interferon gamma	Mus musculus	0-9
11159015-0	2001	Regulation of PDGFR-alpha in rat pulmonary myofibroblasts by staurosporine.	Staurosporine	61-74	platelet derived growth factor receptor alpha	Rattus norvegicus	14-25
11159015-3	2001	In this study, we report that staurosporine, a broad-spectrum kinase inhibitor, upregulates PDGFR-alpha gene expression and protein.	Staurosporine	30-43	platelet derived growth factor receptor alpha	Rattus norvegicus	92-103
11159015-7	2001	However, both staurosporine- and IL-1beta-induced phosphorylation of p38 mitogen-activated protein kinase and upregulation of PDGFR-alpha by these two agents was inhibited by the p38 inhibitor SB-203580.	Staurosporine	14-27	mitogen activated protein kinase 14	Rattus norvegicus	69-72
11159015-7	2001	However, both staurosporine- and IL-1beta-induced phosphorylation of p38 mitogen-activated protein kinase and upregulation of PDGFR-alpha by these two agents was inhibited by the p38 inhibitor SB-203580.	Staurosporine	14-27	platelet derived growth factor receptor alpha	Rattus norvegicus	126-137
11159015-7	2001	However, both staurosporine- and IL-1beta-induced phosphorylation of p38 mitogen-activated protein kinase and upregulation of PDGFR-alpha by these two agents was inhibited by the p38 inhibitor SB-203580.	Staurosporine	14-27	mitogen activated protein kinase 14	Rattus norvegicus	179-182
11159015-8	2001	Finally, staurosporine inhibited basal and PDGF-stimulated mitogenesis over the same concentration range that induced PDGFR-alpha expression.	Staurosporine	9-22	platelet derived growth factor receptor alpha	Rattus norvegicus	118-129
11031259-4	2001	In particular, asmase(-/-) MEFs failed to generate ceramide and were totally resistant to radiation-induced apoptosis but remained sensitive to staurosporine, which did not induce ceramide.	Staurosporine	144-157	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	15-21
11162250-4	2001	Staurosporine-induced Tau cleavage was blocked by 20 microM z-Asp-Glu-Val-Asp-chloromethylketone, a caspase-3 inhibitor, and in vitro, Tau was selectively cleaved by caspase-3 or calpain, a calcium-activated protease, but not by caspases-1, -8, or -9.	Staurosporine	0-13	caspase 3	Homo sapiens	100-109
11162250-4	2001	Staurosporine-induced Tau cleavage was blocked by 20 microM z-Asp-Glu-Val-Asp-chloromethylketone, a caspase-3 inhibitor, and in vitro, Tau was selectively cleaved by caspase-3 or calpain, a calcium-activated protease, but not by caspases-1, -8, or -9.	Staurosporine	0-13	caspase 3	Homo sapiens	166-175
11162250-4	2001	Staurosporine-induced Tau cleavage was blocked by 20 microM z-Asp-Glu-Val-Asp-chloromethylketone, a caspase-3 inhibitor, and in vitro, Tau was selectively cleaved by caspase-3 or calpain, a calcium-activated protease, but not by caspases-1, -8, or -9.	Staurosporine	0-13	caspase 1	Homo sapiens	229-250
11313973-7	2001	Furthermore, staurosporine, an inhibitor for a broad range of serine/threonine kinases including cdc2, was found to enhance hyperploid formation in U251MG cells by accelerating the induction of mitotic slippage.	Staurosporine	13-26	cyclin dependent kinase 1	Homo sapiens	97-101
11313973-9	2001	Moreover, the enhancement of hyperploid formation by staurosporine was also blocked by p53-dependent G1 checkpoint.	Staurosporine	53-66	tumor protein p53	Homo sapiens	87-90
11163773-4	2001	TFF2 transcription was enhanced by indomethacin and arachidonic acid but repressed by staurosporine, suggesting mediation via protein kinase C. We mapped an aspirin responding element -546 to -758 bp upstream of TFF2.	Staurosporine	86-99	trefoil factor 2	Homo sapiens	0-4
11205865-3	2001	Staurosporine (10 nM), epalrestat (10 microM) suppressed the expression of ICAM-1 mRNA and protein induced by high glucose to variable extents.	Staurosporine	0-13	intercellular adhesion molecule 1	Homo sapiens	75-81
11299740-7	2001	In addition, staurosporine or UCNO1 specifically sensitized p53 incompetent cells to adriamycin.	Staurosporine	13-26	tumor protein p53	Homo sapiens	60-63
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	Staurosporine	135-148	protein kinase C alpha	Homo sapiens	79-82
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	Staurosporine	135-148	protein kinase C alpha	Homo sapiens	101-104
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	Staurosporine	135-148	angiotensinogen	Homo sapiens	185-191
11182772-9	2001	The inhibition of the Na+/K+ATPase activity was dependent on protein kinase C (PKC) activation since PKC antagonists (calphostin C and staurosporine) abolished the inhibitory effect of Ang II, and the PKC activator phorbol 12-myristate 13-acetate reduced transporter activity.	Staurosporine	135-148	protein kinase C alpha	Homo sapiens	101-104
11181819-5	2001	By contrast, wild-type alpha-synuclein transfectants were sensitive to viability loss induced by staurosporine, lactacystin or 4-hydroxy-2-trans-nonenal (HNE).	Staurosporine	97-110	synuclein alpha	Homo sapiens	23-38
11053413-2	2001	In this work, we report that PARG is cleaved during etoposide-, staurosporine-, and Fas-induced apoptosis in human cells.	Staurosporine	64-77	poly(ADP-ribose) glycohydrolase	Homo sapiens	29-33
11166791-7	2001	Such an effect was significantly inhibited by the addition of trifluoperazine (2x10(-5) M), an antagonist of calmodulin, or staurosporine (10(-6) M), an inhibitor of protein kinase C. The present study demonstrates that endogenous regucalcin in rat brain neuronal cells has an inhibitory effect on Ca2+ dependent protein kinase activity.	Staurosporine	124-137	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	166-180
11166791-7	2001	Such an effect was significantly inhibited by the addition of trifluoperazine (2x10(-5) M), an antagonist of calmodulin, or staurosporine (10(-6) M), an inhibitor of protein kinase C. The present study demonstrates that endogenous regucalcin in rat brain neuronal cells has an inhibitory effect on Ca2+ dependent protein kinase activity.	Staurosporine	124-137	regucalcin	Rattus norvegicus	231-241
11166791-7	2001	Such an effect was significantly inhibited by the addition of trifluoperazine (2x10(-5) M), an antagonist of calmodulin, or staurosporine (10(-6) M), an inhibitor of protein kinase C. The present study demonstrates that endogenous regucalcin in rat brain neuronal cells has an inhibitory effect on Ca2+ dependent protein kinase activity.	Staurosporine	124-137	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	313-327
11684814-6	2001	This effect of insulin was inhibited by amiloride and by staurosporine as well.	Staurosporine	57-70	insulin	Homo sapiens	15-22
11408768-6	2001	Herbimycin A, genistein, staurosporin and emedastine were all able to inhibit the eotaxin-elicited migration.	Staurosporine	25-37	C-C motif chemokine ligand 11	Homo sapiens	82-89
11296547-3	2001	We found that staurosporine-mediated chondrocyte death depended on the concentration and time of incubation, and coincided with increased Bax:Bcl-X mRNA expression, cytochrome C release, and activation of caspase-3.	Staurosporine	14-27	BCL2 associated X, apoptosis regulator	Homo sapiens	138-141
11296547-3	2001	We found that staurosporine-mediated chondrocyte death depended on the concentration and time of incubation, and coincided with increased Bax:Bcl-X mRNA expression, cytochrome C release, and activation of caspase-3.	Staurosporine	14-27	BCL2 like 1	Homo sapiens	142-147
11296547-3	2001	We found that staurosporine-mediated chondrocyte death depended on the concentration and time of incubation, and coincided with increased Bax:Bcl-X mRNA expression, cytochrome C release, and activation of caspase-3.	Staurosporine	14-27	cytochrome c, somatic	Homo sapiens	165-177
11296547-3	2001	We found that staurosporine-mediated chondrocyte death depended on the concentration and time of incubation, and coincided with increased Bax:Bcl-X mRNA expression, cytochrome C release, and activation of caspase-3.	Staurosporine	14-27	caspase 3	Homo sapiens	205-214
11296547-5	2001	Cell protection coincided with inhibition of the staurosporine-mediated induction of caspase-3 activation.	Staurosporine	49-62	caspase 3	Homo sapiens	85-94
11455566-8	2001	Moreover, the effect of antibody in increasing protein kinase activity was significantly inhibited in the presence of trifluoperazine, staurosporine, or genistein, indicating that endogenous regucalcin has an inhibitory effect on Ca(2+)/calmodulin-dependent protein kinase, protein kinase C, and protein tyrosine kinase.	Staurosporine	135-148	regucalcin	Rattus norvegicus	191-201
11419696-3	2001	The PLD activation induced by BK was blocked by pretreatment of A-431 cells with staurosporine, or by prolonged treatment with phorbol-12-myristate-13-acetate (PMA).	Staurosporine	81-94	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
11419696-3	2001	The PLD activation induced by BK was blocked by pretreatment of A-431 cells with staurosporine, or by prolonged treatment with phorbol-12-myristate-13-acetate (PMA).	Staurosporine	81-94	kininogen 1	Homo sapiens	30-32
11123359-1	2001	Expression of the transforming oncogene bcr-abl in chronic myelogenous leukemia (CML) cells is reported to confer resistance against apoptosis induced by many chemotherapeutic agents such as etoposide, ara-C, and staurosporine.	Staurosporine	213-226	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	40-47
11154867-2	2001	It has been demonstrated that the protease caspase-3, a downstream molecule of the CD95 pathway, is activated in UV-exposed HaCaT cells, and that the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is cleaved by interleukin-1beta converting enzyme (ICE)-like protease during apoptosis induced by X-rays, staurosporine and etoposide.	Staurosporine	314-327	caspase 3	Homo sapiens	43-52
11154867-2	2001	It has been demonstrated that the protease caspase-3, a downstream molecule of the CD95 pathway, is activated in UV-exposed HaCaT cells, and that the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is cleaved by interleukin-1beta converting enzyme (ICE)-like protease during apoptosis induced by X-rays, staurosporine and etoposide.	Staurosporine	314-327	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	150-196
11154867-2	2001	It has been demonstrated that the protease caspase-3, a downstream molecule of the CD95 pathway, is activated in UV-exposed HaCaT cells, and that the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is cleaved by interleukin-1beta converting enzyme (ICE)-like protease during apoptosis induced by X-rays, staurosporine and etoposide.	Staurosporine	314-327	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	198-206
11154867-2	2001	It has been demonstrated that the protease caspase-3, a downstream molecule of the CD95 pathway, is activated in UV-exposed HaCaT cells, and that the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is cleaved by interleukin-1beta converting enzyme (ICE)-like protease during apoptosis induced by X-rays, staurosporine and etoposide.	Staurosporine	314-327	caspase 1	Homo sapiens	222-257
11123279-3	2001	We report that in CD4(+) human lymphoblastoid cell lines transfected with the nef cDNA obtained from three different HIV-1 strains, expression of the Nef protein enhances and accelerates the response to four unrelated apoptotic agents (staurosporine, anisomycin, camptothecin, and etoposide) but not to an anti-Fas agonist Ab.	Staurosporine	236-249	S100 calcium binding protein B	Homo sapiens	78-81
11123279-3	2001	We report that in CD4(+) human lymphoblastoid cell lines transfected with the nef cDNA obtained from three different HIV-1 strains, expression of the Nef protein enhances and accelerates the response to four unrelated apoptotic agents (staurosporine, anisomycin, camptothecin, and etoposide) but not to an anti-Fas agonist Ab.	Staurosporine	236-249	Nef	Human immunodeficiency virus 1	150-153
11145745-5	2001	Staurosporine, a protein kinase C (PKC) and protein kinase A (PKA) inhibitor, blocked both basal and hGH-induced proliferation in INS-1 cells, but had no inhibitory effect in primary beta-cells.	Staurosporine	0-13	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	44-60
11158204-3	2001	However, we have recently found that high concentrations of staurosporine up to 1 microM: can only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKCalpha-mediated Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase (SRK).	Staurosporine	60-73	interleukin 3	Homo sapiens	117-121
11158204-3	2001	However, we have recently found that high concentrations of staurosporine up to 1 microM: can only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKCalpha-mediated Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase (SRK).	Staurosporine	60-73	BCL2 apoptosis regulator	Homo sapiens	133-137
11158204-3	2001	However, we have recently found that high concentrations of staurosporine up to 1 microM: can only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKCalpha-mediated Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase (SRK).	Staurosporine	60-73	protein kinase C alpha	Homo sapiens	175-183
11158204-3	2001	However, we have recently found that high concentrations of staurosporine up to 1 microM: can only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKCalpha-mediated Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase (SRK).	Staurosporine	60-73	BCL2 apoptosis regulator	Homo sapiens	193-197
11158204-3	2001	However, we have recently found that high concentrations of staurosporine up to 1 microM: can only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKCalpha-mediated Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase (SRK).	Staurosporine	60-73	protein kinase C alpha	Homo sapiens	175-178
11158204-3	2001	However, we have recently found that high concentrations of staurosporine up to 1 microM: can only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKCalpha-mediated Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase (SRK).	Staurosporine	60-73	ribosomal protein S6 kinase B2	Homo sapiens	263-298
11158204-3	2001	However, we have recently found that high concentrations of staurosporine up to 1 microM: can only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKCalpha-mediated Bcl2 phosphorylation in vitro, indicating the existence of a non-PKC, staurosporine-resistant Bcl2 kinase (SRK).	Staurosporine	60-73	ribosomal protein S6 kinase B2	Homo sapiens	300-303
11158204-7	2001	These findings indicate a novel role for ERK1 and 2 as molecular links between proliferative and survival signaling and may, at least in part, explain the apparent paradox by which Bcl2 may suppress staurosporine-induced apoptosis.	Staurosporine	199-212	mitogen-activated protein kinase 3	Homo sapiens	41-51
11158204-7	2001	These findings indicate a novel role for ERK1 and 2 as molecular links between proliferative and survival signaling and may, at least in part, explain the apparent paradox by which Bcl2 may suppress staurosporine-induced apoptosis.	Staurosporine	199-212	BCL2 apoptosis regulator	Homo sapiens	181-185
11145745-5	2001	Staurosporine, a protein kinase C (PKC) and protein kinase A (PKA) inhibitor, blocked both basal and hGH-induced proliferation in INS-1 cells, but had no inhibitory effect in primary beta-cells.	Staurosporine	0-13	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	62-65
11226677-7	2001	Cells overexpressing Bcl-xL were significantly protected from beta-amyloid neurotoxicity and staurosporine-induced apoptosis compared to vector-transfected controls.	Staurosporine	93-106	BCL2 like 1	Homo sapiens	21-27
11145745-5	2001	Staurosporine, a protein kinase C (PKC) and protein kinase A (PKA) inhibitor, blocked both basal and hGH-induced proliferation in INS-1 cells, but had no inhibitory effect in primary beta-cells.	Staurosporine	0-13	insulin 1	Rattus norvegicus	130-135
11146107-0	2000	Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.	Staurosporine	0-13	caspase 2	Homo sapiens	92-101
11146107-0	2000	Staurosporine- and H-7-induced cell death in SH-SY5Y neuroblastoma cells is associated with caspase-2 and caspase-3 activation, but not with activation of the FAS/FAS-L-caspase-8 signaling pathway.	Staurosporine	0-13	caspase 3	Homo sapiens	106-115
11146107-3	2000	The process is inhibited with DEVD-fmk, a potent caspase-3 (and caspase-8) inhibitor, thus indicating that staurosporine- and H-7-induced cell death in SH-SY5Y is mediated by caspase activation.	Staurosporine	107-120	caspase 3	Homo sapiens	49-58
11146107-3	2000	The process is inhibited with DEVD-fmk, a potent caspase-3 (and caspase-8) inhibitor, thus indicating that staurosporine- and H-7-induced cell death in SH-SY5Y is mediated by caspase activation.	Staurosporine	107-120	caspase 8	Homo sapiens	64-73
11108286-8	2000	Protein kinase C inhibitors such as calphostin and staurosporin suppressed ionomycin- and PMA-induced osteoclast formation in cocultures and expression of RANKL and OPG mRNAs in primary osteoblasts.	Staurosporine	51-63	peroneal muscular atrophy	Mus musculus	90-93
11121462-9	2000	Staurosporine-mediated G(0)/G(1) arrest targets the retinoblastoma protein (pRb) pathway and was accompanied by a rapid decrease in cyclin-dependent kinase (CDK) 4 protein levels, increased binding of CDK inhibitors p21 and p27 to CDK2, and inhibition of CDK2 activity in normal cells.	Staurosporine	0-13	RB transcriptional corepressor 1	Homo sapiens	76-79
11121462-9	2000	Staurosporine-mediated G(0)/G(1) arrest targets the retinoblastoma protein (pRb) pathway and was accompanied by a rapid decrease in cyclin-dependent kinase (CDK) 4 protein levels, increased binding of CDK inhibitors p21 and p27 to CDK2, and inhibition of CDK2 activity in normal cells.	Staurosporine	0-13	cyclin dependent kinase 4	Homo sapiens	132-163
11121462-9	2000	Staurosporine-mediated G(0)/G(1) arrest targets the retinoblastoma protein (pRb) pathway and was accompanied by a rapid decrease in cyclin-dependent kinase (CDK) 4 protein levels, increased binding of CDK inhibitors p21 and p27 to CDK2, and inhibition of CDK2 activity in normal cells.	Staurosporine	0-13	cyclin dependent kinase 2	Homo sapiens	157-160
11121462-9	2000	Staurosporine-mediated G(0)/G(1) arrest targets the retinoblastoma protein (pRb) pathway and was accompanied by a rapid decrease in cyclin-dependent kinase (CDK) 4 protein levels, increased binding of CDK inhibitors p21 and p27 to CDK2, and inhibition of CDK2 activity in normal cells.	Staurosporine	0-13	cyclin dependent kinase inhibitor 1A	Homo sapiens	216-219
11121462-9	2000	Staurosporine-mediated G(0)/G(1) arrest targets the retinoblastoma protein (pRb) pathway and was accompanied by a rapid decrease in cyclin-dependent kinase (CDK) 4 protein levels, increased binding of CDK inhibitors p21 and p27 to CDK2, and inhibition of CDK2 activity in normal cells.	Staurosporine	0-13	interferon alpha inducible protein 27	Homo sapiens	224-227
11121462-9	2000	Staurosporine-mediated G(0)/G(1) arrest targets the retinoblastoma protein (pRb) pathway and was accompanied by a rapid decrease in cyclin-dependent kinase (CDK) 4 protein levels, increased binding of CDK inhibitors p21 and p27 to CDK2, and inhibition of CDK2 activity in normal cells.	Staurosporine	0-13	cyclin dependent kinase 2	Homo sapiens	231-235
11121462-9	2000	Staurosporine-mediated G(0)/G(1) arrest targets the retinoblastoma protein (pRb) pathway and was accompanied by a rapid decrease in cyclin-dependent kinase (CDK) 4 protein levels, increased binding of CDK inhibitors p21 and p27 to CDK2, and inhibition of CDK2 activity in normal cells.	Staurosporine	0-13	cyclin dependent kinase 2	Homo sapiens	255-259
11121462-10	2000	CONCLUSIONS: Breast cancer cells with defective checkpoints regulated by the pRb pathway can be targeted specifically with chemotherapeutic agents, following staurosporine-mediated, selective and reversible G(0)/G(1) arrest in normal cells.	Staurosporine	158-171	RB transcriptional corepressor 1	Homo sapiens	77-80
11119719-4	2000	CREB was specifically cleaved by caspases in neuroblastoma extracts, and in cells induced to undergo apoptosis by staurosporine.	Staurosporine	114-127	cAMP responsive element binding protein 1	Homo sapiens	0-4
11120786-3	2000	Our results show that a herbimycin A- and staurosporine-sensitive phase of CDK4 expression and activity preceded the acquisition of IL-2-responsiveness in mitogen-stimulated peripheral blood T cells.	Staurosporine	42-55	cyclin dependent kinase 4	Homo sapiens	75-79
11120786-3	2000	Our results show that a herbimycin A- and staurosporine-sensitive phase of CDK4 expression and activity preceded the acquisition of IL-2-responsiveness in mitogen-stimulated peripheral blood T cells.	Staurosporine	42-55	interleukin 2	Homo sapiens	132-136
11120786-5	2000	These T cells proliferated in response to IL-2 without additional mitogens, and both the expression and activity of CDK4 and the ability to respond to cytokines were resistant to herbimycin A and staurosporine.	Staurosporine	196-209	cyclin dependent kinase 4	Homo sapiens	116-120
11078714-2	2000	Pharmacological inhibition of PKC by staurosporine and GF-109203X doubled IP production over that achieved in response to ANG II alone.	Staurosporine	37-50	protein kinase C, gamma	Rattus norvegicus	30-33
11078718-6	2000	Staurosporine and the PKC-delta inhibitor rottlerin inhibited TNF-alpha-triggered serine but not threonine phosphorylation.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	62-71
11145176-6	2000	This inhibition was reversed by subsequent application of staurosporine (1 nM), a PKC inhibitor.	Staurosporine	58-71	protein kinase C, gamma	Rattus norvegicus	82-85
11145176-7	2000	Application of 1-oleoyl-2-acetylglycerol (OAG, 30 microM), another PKC activator, also inhibited the A 23187-induced activation of the K+ channel, and this inhibition was reversed by staurosporine.	Staurosporine	183-196	protein kinase C, gamma	Rattus norvegicus	67-70
11151765-8	2000	Notably, the protein kinase C inhibitors calphostin C and staurosporine reduced high glucose- or high mannitol-induced intercellular adhesion molecule-1 mRNA expression and high glucose-induced proliferation.	Staurosporine	58-71	intercellular adhesion molecule 1	Rattus norvegicus	119-152
11197217-0	2000	Anti-apoptotic role of Bfl-1 in staurosporine-treated B-lymphoblastic cells.	Staurosporine	32-45	BCL2 related protein A1	Homo sapiens	23-28
11197217-1	2000	To examine the relationship between the expression level of Bfl-1 and the susceptibility to staurosporine-induced apoptosis in B-lymphoblastic cells, we tested cell survival in 4 cell lines: 2 that are Bfl-1-nonexpressing (Reh and JM-1) and 2 that are Bfl-1-expressing (IM-9 and Wil2-NS).	Staurosporine	92-105	BCL2 related protein A1	Homo sapiens	60-65
11197217-2	2000	Reh and JM-1 showed apoptosis levels of 62% (Reh) and 30% (JM-1) as early as 3 hours after treatment with staurosporine, whereas IM-9 and Wil2-NS showed apoptosis levels of only 40% and 26%, respectively, even after 1 day of treatment with staurosporine.	Staurosporine	106-119	coiled-coil domain containing 22	Homo sapiens	8-12
11197217-2	2000	Reh and JM-1 showed apoptosis levels of 62% (Reh) and 30% (JM-1) as early as 3 hours after treatment with staurosporine, whereas IM-9 and Wil2-NS showed apoptosis levels of only 40% and 26%, respectively, even after 1 day of treatment with staurosporine.	Staurosporine	106-119	coiled-coil domain containing 22	Homo sapiens	59-63
11095633-0	2000	Green cone opsin and rhodopsin regulation by CNTF and staurosporine in cultured chick photoreceptors.	Staurosporine	54-67	opsin 1 (cone pigments), short-wave-sensitive (violet cone opsin)	Gallus gallus	11-16
11095633-0	2000	Green cone opsin and rhodopsin regulation by CNTF and staurosporine in cultured chick photoreceptors.	Staurosporine	54-67	rhodopsin	Gallus gallus	21-30
11095633-6	2000	Staurosporine-treated cultures also had more Rho4D2-immunoreactive cells than control cultures, but this increase was accompanied by induction of rhodopsin expression, with concomitant decreases in levels of green cone pigment mRNA.	Staurosporine	0-13	rhodopsin	Gallus gallus	146-155
11093788-4	2000	PKC inhibitors (staurosporine, Ro 31-8220, calphostin C, or Go 6976) also inhibited IL-1beta-induced response.	Staurosporine	16-29	protein kinase C alpha	Homo sapiens	0-3
11093788-4	2000	PKC inhibitors (staurosporine, Ro 31-8220, calphostin C, or Go 6976) also inhibited IL-1beta-induced response.	Staurosporine	16-29	interleukin 1 beta	Homo sapiens	84-92
11035812-4	2000	Immunocytochemistry and subcellular fractionation revealed that PMA, like tert-butylhydroquinone (tBHQ), promoted the nuclear localization of Nrf2, a process that was blocked by staurosporine or Ro-32-0432.	Staurosporine	178-191	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
11035812-6	2000	PMA transiently activated Nrf2 phosphorylation, whereas the addition of tBHQ or beta-naphthoflavone (betaNF) led to a persistent stimulation, which was abolished by staurosporine, but not by U0126 and SB203580, respective inhibitors of MEK and p38 kinases.	Staurosporine	165-178	mitogen-activated protein kinase 14	Homo sapiens	244-247
11053043-5	2000	Because angiotensin II activates protein kinase C, we tested the effect of staurosporine (SSP).	Staurosporine	75-88	angiotensinogen	Rattus norvegicus	8-22
10978848-6	2000	Staurosporine and calphostin C also inhibited the PRL effect by 50%, consistent with involvement of protein kinase C-(PKC)-alpha, the major PKC isoform in astrocytes.	Staurosporine	0-13	prolactin	Homo sapiens	50-53
11032874-3	2000	Following induction of apoptosis by staurosporine, the immunoreactivity of the type I IP(3) receptor in microsome preparations from SH-SY5Y cells was reduced within 2 h, with a further reduction during subsequent hours.	Staurosporine	36-49	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	86-100
11035063-5	2000	Additionally, staurosporine, which severely inhibited the activation of mitogen-activated protein (MAP) family kinases and c-Jun, partially blocked the NaAsO(2)-mediated signal for poly(ADP-ribose) polymerase (PARP) degradation.	Staurosporine	14-27	jun proto-oncogene	Mus musculus	123-128
11035063-5	2000	Additionally, staurosporine, which severely inhibited the activation of mitogen-activated protein (MAP) family kinases and c-Jun, partially blocked the NaAsO(2)-mediated signal for poly(ADP-ribose) polymerase (PARP) degradation.	Staurosporine	14-27	poly (ADP-ribose) polymerase family, member 1	Mus musculus	181-208
11035063-5	2000	Additionally, staurosporine, which severely inhibited the activation of mitogen-activated protein (MAP) family kinases and c-Jun, partially blocked the NaAsO(2)-mediated signal for poly(ADP-ribose) polymerase (PARP) degradation.	Staurosporine	14-27	poly (ADP-ribose) polymerase family, member 1	Mus musculus	210-214
10908570-3	2000	This response was partially inhibited by cyclosporin A and staurosporine, suggesting the participation of both the Ca(2+) and the protein kinase C pathways in CD43 signaling.	Staurosporine	59-72	sialophorin	Homo sapiens	159-163
11226677-5	2001	In contrast, apoptotic stimuli (exposure to staurosporine or serum withdrawal) actually decreased neuronal Bcl-xL expression.	Staurosporine	44-57	BCL2 like 1	Homo sapiens	107-113
11095605-3	2000	For proliferation studies, primary cultures of rat corneal endothelial cells were serum-starved for 48 hours and incubated for 2 hours with the PKC inhibitors staurosporine (10(-9) to 10(-7) M), chelerythrine (10(-9) to 5 x 10(-8) M), or calphostin C (10(-9) to 10(-7) M).	Staurosporine	159-172	protein kinase C, gamma	Rattus norvegicus	144-147
11095605-9	2000	Maximum inhibition of PKC with staurosporine, calphostin C, and chelerythrine reduced cell proliferation to 7%, 31%, and 48% of control, respectively.	Staurosporine	31-44	protein kinase C, gamma	Rattus norvegicus	22-25
11095605-12	2000	Cyclin E protein level was decreased to 70%, 38%, 57%, and 43% of control in cells treated with calphostin C, staurosporine, chelerythrine, and PKCalpha antisense, respectively.	Staurosporine	110-123	cyclin E1	Rattus norvegicus	0-8
11056010-4	2000	The purpose of this study was to examine the effects of estrogen on staurosporine-induced apoptosis in the context of hsp27 expression.	Staurosporine	68-81	heat shock protein family B (small) member 1	Rattus norvegicus	118-123
11187905-6	2000	However, activation of both caspase-8 and caspase-3 was achieved in BR97 cells treated with staurosporine.	Staurosporine	92-105	caspase 8	Homo sapiens	28-37
11187905-6	2000	However, activation of both caspase-8 and caspase-3 was achieved in BR97 cells treated with staurosporine.	Staurosporine	92-105	caspase 3	Homo sapiens	42-51
11095953-5	2000	In parallel studies, PMA induced increased expression of the p47 component of the NAD(P)H oxidase in the particulate fraction, which was inhibited by staurosporine and calphostin.	Staurosporine	150-163	NSFL1 (p97) cofactor (p47)	Mus musculus	61-64
11095953-5	2000	In parallel studies, PMA induced increased expression of the p47 component of the NAD(P)H oxidase in the particulate fraction, which was inhibited by staurosporine and calphostin.	Staurosporine	150-163	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	82-89
11117479-5	2000	Additionally, PEP-19-expressing cells displayed decreased DNA ladder formation, chromatin and condensation, caspase activation following staurosporine treatment.	Staurosporine	137-150	Purkinje cell protein 4	Rattus norvegicus	14-20
11052997-6	2000	As shown by Northern blotting, h-sgk transcription in DAN-G pancreatic tumor cells is upregulated by osmotic cell shrinkage, serum, phorbol esters (phorbol 12,13-didecanoate), and Ca(2+) ionophore A-23187 and decreased by staurosporine and cAMP.	Staurosporine	222-235	serum/glucocorticoid regulated kinase 1	Homo sapiens	33-36
11052997-6	2000	As shown by Northern blotting, h-sgk transcription in DAN-G pancreatic tumor cells is upregulated by osmotic cell shrinkage, serum, phorbol esters (phorbol 12,13-didecanoate), and Ca(2+) ionophore A-23187 and decreased by staurosporine and cAMP.	Staurosporine	222-235	NBL1, DAN family BMP antagonist	Homo sapiens	54-57
11034905-2	2000	Using various cell systems, including Jurkat, HL-60, and HeLa cells, and different death-inducing agents, such as anti-Fas antibody, topoisomerase inhibitors, and staurosporine, we found that LAP2 alpha was cleaved during apoptosis as rapidly as lamin B in a caspase-dependent manner yielding stable N- and C-terminal fragments of approximately 50 and 28 kDa, respectively.	Staurosporine	163-176	thymopoietin	Homo sapiens	192-196
11046085-3	2000	TPeA and THA (0.1-1.0 microM) attenuated staurosporine-induced caspase-3 activation and neuronal apoptosis.	Staurosporine	41-54	caspase 3	Mus musculus	63-72
11040047-7	2000	When treated with an anticancer drug (etoposide or cisplatin) or the kinase inhibitor staurosporin, the cells containing a high G(1) population and a high Bcl-2 protein level were much more resistant to the induced apoptosis than the cells containing a high S phase population and a low Bcl-2 protein level.	Staurosporine	86-98	BCL2 apoptosis regulator	Homo sapiens	155-160
11040047-7	2000	When treated with an anticancer drug (etoposide or cisplatin) or the kinase inhibitor staurosporin, the cells containing a high G(1) population and a high Bcl-2 protein level were much more resistant to the induced apoptosis than the cells containing a high S phase population and a low Bcl-2 protein level.	Staurosporine	86-98	BCL2 apoptosis regulator	Homo sapiens	287-292
11058115-3	2000	We report here that caspase-3 and calpain can form p140 from p261 in vitro and in vivo and that during early stages of apoptosis induced in Jurkat cells by staurosporine or anti-Fas-activating antibody, p261 is cleaved into p140 by caspase-3.	Staurosporine	156-169	caspase 3	Homo sapiens	20-29
11058115-3	2000	We report here that caspase-3 and calpain can form p140 from p261 in vitro and in vivo and that during early stages of apoptosis induced in Jurkat cells by staurosporine or anti-Fas-activating antibody, p261 is cleaved into p140 by caspase-3.	Staurosporine	156-169	SRC kinase signaling inhibitor 1	Homo sapiens	51-55
10998561-3	2000	Staurosporine-induced cytotoxicity was accompanied by the activation of caspase 3-like protease(s) and disintegration of nuclear DNA into the HMW- and oligonucleosomal DNA fragments.	Staurosporine	0-13	caspase 3	Mus musculus	72-81
11090628-0	2000	Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.	Staurosporine	115-128	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	27-52
11090628-2	2000	The X-ray crystallographic structures of PI3Kgamma bound to these lipid kinase inhibitors and to the broad-spectrum protein kinase inhibitors quercetin, myricetin, and staurosporine reveal how these compounds fit into the ATP binding pocket.	Staurosporine	168-181	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	41-50
11039466-4	2000	Staurosporine significantly inhibited CCK release from STC-1 cells stimulated by TPA in a dose-dependent manner.	Staurosporine	0-13	cholecystokinin	Mus musculus	38-41
11039466-4	2000	Staurosporine significantly inhibited CCK release from STC-1 cells stimulated by TPA in a dose-dependent manner.	Staurosporine	0-13	stanniocalcin 1	Mus musculus	55-60
11039466-4	2000	Staurosporine significantly inhibited CCK release from STC-1 cells stimulated by TPA in a dose-dependent manner.	Staurosporine	0-13	promotion susceptibility QTL 1	Mus musculus	81-84
10987998-3	2000	Staurosporine transiently increased the phosphotransferase activity of c-Jun N-terminal kinase-1 (JNK1), which in turn may activate the transcriptional activity of activating protein-1 (AP-1).	Staurosporine	0-13	mitogen-activated protein kinase 8	Mus musculus	71-96
10987998-3	2000	Staurosporine transiently increased the phosphotransferase activity of c-Jun N-terminal kinase-1 (JNK1), which in turn may activate the transcriptional activity of activating protein-1 (AP-1).	Staurosporine	0-13	mitogen-activated protein kinase 8	Mus musculus	98-102
10987998-6	2000	Furthermore, staurosporine increased the transcriptional activity of nuclear factor- kappa B (NF- kappa B).	Staurosporine	13-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-105
10987998-7	2000	These data suggest that staurosporine-induced apoptosis in osteoblasts may occur via activation of JNK1, caspase-3-like proteases, and transcriptional factors including AP-1 and NF- kappa B.	Staurosporine	24-37	mitogen-activated protein kinase 8	Mus musculus	99-103
10987998-7	2000	These data suggest that staurosporine-induced apoptosis in osteoblasts may occur via activation of JNK1, caspase-3-like proteases, and transcriptional factors including AP-1 and NF- kappa B.	Staurosporine	24-37	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-189
11087070-6	2000	Both phorbol-12-myristate-13-acetate (PMA) and DIDS can induce increased translocation of p47-phox of the neutrophil to the membrane fraction, which is inhibited by STP pretreatment.	Staurosporine	165-168	NSFL1 (p97) cofactor (p47)	Mus musculus	90-93
11108286-8	2000	Protein kinase C inhibitors such as calphostin and staurosporin suppressed ionomycin- and PMA-induced osteoclast formation in cocultures and expression of RANKL and OPG mRNAs in primary osteoblasts.	Staurosporine	51-63	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	155-160
11108286-8	2000	Protein kinase C inhibitors such as calphostin and staurosporin suppressed ionomycin- and PMA-induced osteoclast formation in cocultures and expression of RANKL and OPG mRNAs in primary osteoblasts.	Staurosporine	51-63	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)	Mus musculus	165-168
10995469-4	2000	Nerve growth factor withdrawal from differentiated PC12 cells and staurosporine treatment of SH-SY5Y cells led to increased phosphorylation at Y(216), GSK3beta activity, and cell death.	Staurosporine	66-79	glycogen synthase kinase 3 beta	Homo sapiens	151-159
10995469-9	2000	However, after staurosporine, a dramatic alteration in the immunolocalization pattern was observed, and Y(216)-phosphorylated GSK3beta selectively increased within the nucleus.	Staurosporine	15-28	glycogen synthase kinase 3 beta	Rattus norvegicus	126-134
11006111-0	2000	Equivalent death of P-glycoprotein expressing and nonexpressing cells induced by the protein kinase C inhibitor staurosporine.	Staurosporine	112-125	ATP binding cassette subfamily B member 1	Homo sapiens	20-34
11006111-6	2000	Consistent with our hypothesis, we demonstrate here that staurosporine can equivalently kill P-gp(+ve) and P-gp(-ve) tumor cell lines in a caspase-independent manner.	Staurosporine	57-70	ATP binding cassette subfamily B member 1	Homo sapiens	93-97
11006111-6	2000	Consistent with our hypothesis, we demonstrate here that staurosporine can equivalently kill P-gp(+ve) and P-gp(-ve) tumor cell lines in a caspase-independent manner.	Staurosporine	57-70	ATP binding cassette subfamily B member 1	Homo sapiens	107-111
11006130-6	2000	Upon staurosporine stimulation, Grb3-3 predisposes Sup-T1 cell to apoptosis.	Staurosporine	5-18	growth factor receptor bound protein 2	Homo sapiens	32-38
11029754-3	2000	Here we report that before the initiation of apoptotic execution by etoposide or staurosporin, an active calpain activity cleaves Bax at its N-terminus, generating a potent proapoptotic 18-kDa fragment (Bax/p18).	Staurosporine	81-93	BCL2 associated X, apoptosis regulator	Homo sapiens	130-133
10972960-5	2000	Pharmacological studies using the PKC activator, phorbol myristate acetate, and inhibitors, calphostin-C, and staurosporine, demonstrated PKC activity to be inversely related to NCAM polysialylation in the mouse neuro-2A cell line.	Staurosporine	110-123	protein kinase C, delta	Mus musculus	138-141
10972960-5	2000	Pharmacological studies using the PKC activator, phorbol myristate acetate, and inhibitors, calphostin-C, and staurosporine, demonstrated PKC activity to be inversely related to NCAM polysialylation in the mouse neuro-2A cell line.	Staurosporine	110-123	neural cell adhesion molecule 1	Mus musculus	178-182
11007454-2	2000	We report the importance of the cytochrome c-mediated caspase-9 death pathway for radiosensitization by the protein kinase C (PKC) inhibitors staurosporine (STP) and PKC-412.	Staurosporine	142-155	cytochrome c, somatic	Homo sapiens	32-44
11007454-2	2000	We report the importance of the cytochrome c-mediated caspase-9 death pathway for radiosensitization by the protein kinase C (PKC) inhibitors staurosporine (STP) and PKC-412.	Staurosporine	142-155	caspase 9	Homo sapiens	54-63
11007454-2	2000	We report the importance of the cytochrome c-mediated caspase-9 death pathway for radiosensitization by the protein kinase C (PKC) inhibitors staurosporine (STP) and PKC-412.	Staurosporine	157-160	cytochrome c, somatic	Homo sapiens	32-44
11007454-2	2000	We report the importance of the cytochrome c-mediated caspase-9 death pathway for radiosensitization by the protein kinase C (PKC) inhibitors staurosporine (STP) and PKC-412.	Staurosporine	157-160	caspase 9	Homo sapiens	54-63
10956420-9	2000	Whereas Bcl-2 overexpression completely blocked both cytochrome C release and apoptosis induced by staurosporine, it attenuated neither induced by TPEN.	Staurosporine	99-112	BCL2 apoptosis regulator	Homo sapiens	8-13
11053666-0	2000	Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine.	Staurosporine	143-156	B cell leukemia/lymphoma 2	Mus musculus	76-81
11053666-0	2000	Comparison of the protective activities generated by two survival proteins: Bcl-2 and Hsp27 in L929 murine fibroblasts exposed to menadione or staurosporine.	Staurosporine	143-156	heat shock protein 1	Mus musculus	86-91
11053666-7	2000	Both Hsp27 and Bcl-2 also conferred cellular resistance to staurosporine, a kinase inhibitor that induces apoptosis without generating an oxidative stress.	Staurosporine	59-72	heat shock protein 1	Mus musculus	5-10
11053666-7	2000	Both Hsp27 and Bcl-2 also conferred cellular resistance to staurosporine, a kinase inhibitor that induces apoptosis without generating an oxidative stress.	Staurosporine	59-72	B cell leukemia/lymphoma 2	Mus musculus	15-20
11071123-4	2000	RESULTS: Staurosporine and chelerythrine exerted a significant inhibitory effect on histamine release induced by anti-IgE, IL-3 and GM-CSF at concentrations much higher than those required to inhibit PKC.	Staurosporine	9-22	interleukin 3	Homo sapiens	123-127
11071123-4	2000	RESULTS: Staurosporine and chelerythrine exerted a significant inhibitory effect on histamine release induced by anti-IgE, IL-3 and GM-CSF at concentrations much higher than those required to inhibit PKC.	Staurosporine	9-22	colony stimulating factor 2	Homo sapiens	132-138
11071123-4	2000	RESULTS: Staurosporine and chelerythrine exerted a significant inhibitory effect on histamine release induced by anti-IgE, IL-3 and GM-CSF at concentrations much higher than those required to inhibit PKC.	Staurosporine	9-22	proline rich transmembrane protein 2	Homo sapiens	200-203
10965039-6	2000	PMA-induced phosphorylation of SNAP-25 was inhibited by staurosporine, however, the potentiation of high-K(+)-dependent DA release was suppressed only partially.	Staurosporine	56-69	synaptosome associated protein 25	Rattus norvegicus	31-38
10934034-8	2000	In the presence of z-DEVD-FMK or Ac-YVAD-CMK, caspase-3 was processed to both the p17 and p20 fragments in staurosporine-treated cells, but only to p20 fragment in the presence of z-VAD-FMK.	Staurosporine	107-120	C-X-C motif chemokine ligand 9	Homo sapiens	41-44
10934034-8	2000	In the presence of z-DEVD-FMK or Ac-YVAD-CMK, caspase-3 was processed to both the p17 and p20 fragments in staurosporine-treated cells, but only to p20 fragment in the presence of z-VAD-FMK.	Staurosporine	107-120	caspase 3	Homo sapiens	46-55
10934034-8	2000	In the presence of z-DEVD-FMK or Ac-YVAD-CMK, caspase-3 was processed to both the p17 and p20 fragments in staurosporine-treated cells, but only to p20 fragment in the presence of z-VAD-FMK.	Staurosporine	107-120	DNA polymerase epsilon 3, accessory subunit	Homo sapiens	82-85
10934034-8	2000	In the presence of z-DEVD-FMK or Ac-YVAD-CMK, caspase-3 was processed to both the p17 and p20 fragments in staurosporine-treated cells, but only to p20 fragment in the presence of z-VAD-FMK.	Staurosporine	107-120	tubulin polymerization promoting protein family member 3	Homo sapiens	90-93
10934034-10	2000	In addition, caspase-3 null MCF-7 cells also undergo pre-apoptotic nuclear change when treated with staurosporine in the presence of caspase inhibitors, indicating that caspase-3 is not required for the early nuclear morphological change in cells undergoing apoptosis.	Staurosporine	100-113	caspase 3	Homo sapiens	13-22
10998058-4	2000	The absence of HsRad51 cleavage in staurosporine-treated apoptotic MCF-7 cells, which lack caspase-3, indicates that caspase-3 is essential for HsRad51 cleavage in vivo.	Staurosporine	35-48	caspase 3	Homo sapiens	91-100
10998058-4	2000	The absence of HsRad51 cleavage in staurosporine-treated apoptotic MCF-7 cells, which lack caspase-3, indicates that caspase-3 is essential for HsRad51 cleavage in vivo.	Staurosporine	35-48	caspase 3	Homo sapiens	117-126
11071120-6	2000	Interestingly, only COX-2 protein, but not COX-1 protein, was induced in 17beta-estradiol treated HUVEC and was also inhibited by staurosporine.	Staurosporine	130-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	20-25
10951498-6	2000	The expression of mRNA of tau, a microtubule-associated protein that is one of the essential components of neurite outgrowth, time-dependently increased in the cells treated with 10(-8) M staurosporine.	Staurosporine	188-201	regulator of microtubule dynamics 1	Homo sapiens	33-63
10987147-5	2000	Accumulation of total inositol phosphate as well as tyrosine phosphorylation of PLC-gamma1 was inhibited by the pretreatment of protein kinase inhibitors such as genistein and staurosporine.	Staurosporine	176-189	phospholipase C, gamma 1	Rattus norvegicus	80-90
10962571-2	2000	During this process there was a dramatic increase in the mitochondrial levels of the apoptosis effector, Bak, due to the stabilization of bak mRNA, which was correlated with the sensitization of HCW-2 cells to respond to the apoptotic effect of staurosporine (STS).	Staurosporine	245-258	BCL2 antagonist/killer 1	Homo sapiens	105-108
10962571-2	2000	During this process there was a dramatic increase in the mitochondrial levels of the apoptosis effector, Bak, due to the stabilization of bak mRNA, which was correlated with the sensitization of HCW-2 cells to respond to the apoptotic effect of staurosporine (STS).	Staurosporine	245-258	BCL2 antagonist/killer 1	Homo sapiens	138-141
10962571-2	2000	During this process there was a dramatic increase in the mitochondrial levels of the apoptosis effector, Bak, due to the stabilization of bak mRNA, which was correlated with the sensitization of HCW-2 cells to respond to the apoptotic effect of staurosporine (STS).	Staurosporine	260-263	BCL2 antagonist/killer 1	Homo sapiens	105-108
10962571-2	2000	During this process there was a dramatic increase in the mitochondrial levels of the apoptosis effector, Bak, due to the stabilization of bak mRNA, which was correlated with the sensitization of HCW-2 cells to respond to the apoptotic effect of staurosporine (STS).	Staurosporine	260-263	BCL2 antagonist/killer 1	Homo sapiens	138-141
10952999-2	2000	Overexpression of calreticulin, an ER luminal protein, resulted in an increased sensitivity of the cells to both thapsigargin- and staurosporine-induced apoptosis.	Staurosporine	131-144	calreticulin	Homo sapiens	18-30
10933864-5	2000	Using the assay we detected 6.6 ng active caspase 3 per 10(6) apoptotic staurosporine-treated Jurkat cells.	Staurosporine	72-85	caspase 3	Homo sapiens	42-51
10818098-6	2000	Interestingly, wt alpha-synuclein drastically reduces the caspase activation of TSM1 neurons upon three distinct apoptotic stimuli including staurosporine, etoposide, and ceramide C(2) when compared with mock-transfected cells.	Staurosporine	141-154	synuclein, alpha	Mus musculus	18-33
10818098-8	2000	Comparison of wild-type and mutated alpha-synuclein-expressing cells also indicates that the former exhibits much less vulnerability in response to staurosporine and etoposide as measured by the sodium 3"-[1-(phenylaminocarbonyl)-3, 4-tetrazolium]-bis(4-methoxy-6-nitro)benzenesulfonic acid assay.	Staurosporine	148-161	synuclein, alpha	Mus musculus	36-51
10967557-10	2000	Additional studies using staurosporine and Ro-31-8220 demonstrate that protein kinase C is required for the glucose up regulation of collagen I and c-jun.	Staurosporine	25-38	jun proto-oncogene	Mus musculus	148-153
10955723-6	2000	The staurosporine-induced DNA ladder formation was accompanied by an increase in caspase-3 activity in both lines which, however, was considerably lower in Jurkat JM cells after gemcitabine or cycloheximide exposure.	Staurosporine	4-17	caspase 3	Homo sapiens	81-90
10930303-7	2000	The glucocorticoid dexamethasone and the protein kinase inhibitor staurosporine distinctively inhibited the IL-8 production of MONO-MAC-6 cells.	Staurosporine	66-79	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
11035262-4	2000	Results showed that cyt c release and caspase activation in response to staurosporine treatment were preserved in cells lacking mitochondrial DNA (rho0 cells).	Staurosporine	72-85	cytochrome c, somatic	Homo sapiens	20-25
10937575-1	2000	PURPOSE: To determine what caspases are activated during staurosporin-induced apoptosis in cultured bovine lens epithelial cells (BLECs), to study the time course of caspase activation in relation to morphologic changes, and to investigate the effect of caspase and/or proteasome inhibition on apoptosis.	Staurosporine	57-69	caspase 1	Bos taurus	27-35
10937575-6	2000	RESULTS: Staurosporin treatment caused a dose- and time-dependent increase in the number of apoptotic cells and in caspase-3 activity.	Staurosporine	9-21	caspase 3	Bos taurus	115-124
10937575-11	2000	Preincubation of lens epithelial cells with caspase inhibitors caused complete inhibition of lactacystin- or staurosporin-induced caspase-3 activation (Z-DEVD-FMK/Z-VAD-FMK) and also of caspase-2, -4, -8, and -9 (Z-VAD-FMK), but the reduction in TUNEL-positive cells was only partial.	Staurosporine	109-121	caspase 3	Bos taurus	130-139
10937575-11	2000	Preincubation of lens epithelial cells with caspase inhibitors caused complete inhibition of lactacystin- or staurosporin-induced caspase-3 activation (Z-DEVD-FMK/Z-VAD-FMK) and also of caspase-2, -4, -8, and -9 (Z-VAD-FMK), but the reduction in TUNEL-positive cells was only partial.	Staurosporine	109-121	caspase 2	Bos taurus	186-211
10937575-13	2000	CONCLUSIONS: Staurosporin-induced apoptosis in BLECs involves activation of several caspases.	Staurosporine	13-25	caspase 1	Bos taurus	84-92
10903772-7	2000	PMA and TNF-alpha stimulation of GM-CSF required activation of PKC (inhibition by staurosporine and bisindolylmaleimide I).	Staurosporine	82-95	tumor necrosis factor	Homo sapiens	8-17
10903772-7	2000	PMA and TNF-alpha stimulation of GM-CSF required activation of PKC (inhibition by staurosporine and bisindolylmaleimide I).	Staurosporine	82-95	colony stimulating factor 2	Homo sapiens	33-39
10908611-9	2000	To investigate the relationship between cytochrome c release and superoxide production, human D283 medulloblastoma cells deficient in mitochondrial respiration (rho(-) cells) were exposed to the apoptosis-inducing agent staurosporine.	Staurosporine	220-233	cytochrome c, somatic	Homo sapiens	40-52
10908611-10	2000	Treatment with staurosporine induced mitochondrial release of cytochrome c, caspase activation, and cell death in control and rho(-) cells.	Staurosporine	15-28	cytochrome c, somatic	Homo sapiens	62-74
11951115-10	2000	Staurosporine, a PKC inhibitor, abolished the inhibiting effect of Ang II on production of NO.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	17-20
11951115-10	2000	Staurosporine, a PKC inhibitor, abolished the inhibiting effect of Ang II on production of NO.	Staurosporine	0-13	angiotensinogen	Rattus norvegicus	67-73
10922462-9	2000	In support of the latter possibility, fibroblasts deficient in CPT I activity were relatively resistant to staurosporine-induced apoptosis.	Staurosporine	107-120	carnitine palmitoyltransferase 1B	Homo sapiens	63-68
10908575-7	2000	Staurosporine-induced apoptosis evoked the proteolysis and disappearance of endogenous and exogenous ICAD from the nuclei of HeLa cells, as monitored by immunoblotting and immunofluorescence microscopy.	Staurosporine	0-13	DNA fragmentation factor subunit alpha	Homo sapiens	101-105
10898738-6	2000	The inhibitory effect of VACM-1 on cAMP production could be reversed by pretreating cells with staurosporin, a protein kinase A (PKA) inhibitor, or by mutating S730A, the PKA-dependent phosphorylation site in the VACM-1 sequence.	Staurosporine	95-107	cullin 5	Homo sapiens	25-31
10869284-8	2000	Gastrin effects on cholangiocyte functions were blocked by L-365,260, BAPTA/AM, H7, and staurosporin but not by L-364,718.	Staurosporine	88-100	gastrin	Rattus norvegicus	0-7
10854251-3	2000	Cortical neurons lacking E2F1 expression (derived from E2F1 -/- mice) were resistant to staurosporine-induced apoptosis as evidenced by the significantly lower caspase 3-like activity and a lesser number of cells with apoptotic morphology in comparison with cortical cultures derived from wild-type mice.	Staurosporine	88-101	E2F transcription factor 1	Mus musculus	25-29
10854251-3	2000	Cortical neurons lacking E2F1 expression (derived from E2F1 -/- mice) were resistant to staurosporine-induced apoptosis as evidenced by the significantly lower caspase 3-like activity and a lesser number of cells with apoptotic morphology in comparison with cortical cultures derived from wild-type mice.	Staurosporine	88-101	E2F transcription factor 1	Mus musculus	55-59
10779388-5	2000	The alpha(1b)-adrenoceptor phosphorylation induced by lysophosphatidic acid was not blocked by genistein, a tyrosine kinase inhibitor, but it was inhibited by inhibitors of protein kinase C (bisindolylmaleimide I, staurosporine, and Ro 31-8220) and phosphoinositide 3-kinase (wortmannin and LY 294002).	Staurosporine	214-227	adrenoceptor alpha 1B	Rattus norvegicus	4-26
10949535-10	2000	Moreover, staurosporine, a serine threonine kinase inhibitor, prevented increased vimentin phosphorylation elicited by melatonin.	Staurosporine	10-23	vimentin	Mus musculus	82-90
10800080-6	2000	In contrast, activation of group I mGluR, including selective activation of mGluR5, significantly attenuated apoptotic cell death induced by both staurosporine and etoposide.	Staurosporine	146-159	glutamate receptor, ionotropic, kainate 1	Mus musculus	76-82
10767399-5	2000	The superoxide generation induced by PMA with timosaponins E1 and E2 was suppressed by staurosporine, an inhibitor of protein kinase C, but was not suppressed by genistein, an inhibitor of protein tyrosine kinase.	Staurosporine	87-100	small nucleolar RNA, H/ACA box 73A	Homo sapiens	59-68
10799837-4	2000	Staurosporine analogues compete with ATP, even though the exact action by which they inhibit PKC is more complicated.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	93-96
10799837-5	2000	Staurosporine analogues do not exhibit specificity for particular PKC isoenzymes, but they inhibit "conventional" PKC isoenzymes more potently than "novel" and "atypical" ones.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	114-117
10772821-6	2000	Deletion mutation experiments showed that the central ubiquitin homology domain of BAG-1 protein was necessary for its promotion of 4-HPR-induced apoptosis, whereas its C-terminal Hsp70/Hsc70-interacting domain was required for its inhibition of staurosporine-induced apoptosis.	Staurosporine	246-259	BAG cochaperone 1	Homo sapiens	83-88
10779771-5	2000	However, compared with EGFP-transduced HUVEC, the Bcl-2-transduced cells are resistant to the apoptotic effects of serum and growth factor withdrawal and are also resistant to the induction of apoptosis by staurosporine or by ceramide, with or without TNF.	Staurosporine	206-219	BCL2 apoptosis regulator	Homo sapiens	50-55
10946303-5	2000	The PKC inhibitor, staurosporine, also inhibited TNF-alpha-induced response.	Staurosporine	19-32	tumor necrosis factor	Homo sapiens	49-58
10946303-7	2000	NF-kappaB DNA-protein binding and COX-2 promoter activity were enhanced by TNF-alpha, and these effects were inhibited by genistein, U73122, staurosporine, or pyrolidine dithiocarbamate.	Staurosporine	141-154	prostaglandin-endoperoxide synthase 2	Homo sapiens	34-39
10946303-7	2000	NF-kappaB DNA-protein binding and COX-2 promoter activity were enhanced by TNF-alpha, and these effects were inhibited by genistein, U73122, staurosporine, or pyrolidine dithiocarbamate.	Staurosporine	141-154	tumor necrosis factor	Homo sapiens	75-84
10861629-7	2000	ST and CP did induce a low but reproducible activation of p38 beginning at around 3 hr and 5 hr, respectively, after the initiation of exposure.	Staurosporine	0-2	mitogen-activated protein kinase 14	Mus musculus	58-61
10779523-7	2000	The phosphorylation of MacMARCKS is important because transfection of a nonphosphorylatable MacMARCKS mutant or the addition of staurosporine eliminates the rapid diffusion rate of integrin.	Staurosporine	128-141	MARCKS-like 1	Mus musculus	23-32
10814818-4	2000	The protein kinase inhibitor, staurosporine, and the protein phosphatase inhibitor, calyculin A, suppressed the wound induction of the FAD7 gene in stems.	Staurosporine	30-43	omega-3 fatty acid desaturase, chloroplastic-like	Nicotiana tabacum	135-139
10861789-0	2000	Retinoic acid potentiated the protective effect of NGF against staurosporine-induced apoptosis in cultured chick neurons by increasing the trkA protein expression.	Staurosporine	63-76	nerve growth factor	Gallus gallus	51-54
10861789-0	2000	Retinoic acid potentiated the protective effect of NGF against staurosporine-induced apoptosis in cultured chick neurons by increasing the trkA protein expression.	Staurosporine	63-76	neurotrophic receptor tyrosine kinase 1	Gallus gallus	139-143
10861789-2	2000	When chick embryonic neurons were exposed to staurosporine (200 nM, 24 hr), the percentage of apoptotic neurons increased from 15% in controls to 80%, but the treatment with NGF alone did not show any neuroprotection.	Staurosporine	45-58	nerve growth factor	Gallus gallus	174-177
10861789-3	2000	In the presence of retinoic acid (RA, 5 microM), however, NGF (20 pg/ml) reduced staurosporine-induced damage to 42% apoptotic neurons compared to 58% in the presence of RA (5 icroM) alone.	Staurosporine	81-94	nerve growth factor	Gallus gallus	58-61
10861789-4	2000	TrkA protein expression in chick neurons was markedly reduced by staurosporine, but was found to be increased in the presence of RA and NGF compared with the treatment with staurosporine alone.	Staurosporine	65-78	neurotrophic receptor tyrosine kinase 1	Gallus gallus	0-4
10861789-4	2000	TrkA protein expression in chick neurons was markedly reduced by staurosporine, but was found to be increased in the presence of RA and NGF compared with the treatment with staurosporine alone.	Staurosporine	173-186	neurotrophic receptor tyrosine kinase 1	Gallus gallus	0-4
10861789-4	2000	TrkA protein expression in chick neurons was markedly reduced by staurosporine, but was found to be increased in the presence of RA and NGF compared with the treatment with staurosporine alone.	Staurosporine	173-186	nerve growth factor	Gallus gallus	136-139
10861789-6	2000	In addition, RA-enhanced 2.6-fold the NGF secretion from cultured rat cortical astrocytes and conditioned medium of RA-treated astrocytes reduced the percentage of apoptotic chick neurons after a 24 hr-incubation with staurosporine in the same manner as the external addition of RA and NGF.	Staurosporine	218-231	nerve growth factor	Rattus norvegicus	38-41
10837353-4	2000	The protein kinase C (PKC) inhibitors staurosporine (10(-6) M) and GF-109203X (10(-6) M) significantly inhibited histamine-stimulated c-fos mRNA while not altering c-jun expression.	Staurosporine	38-51	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	134-139
10822279-4	2000	Here, we show that BID is cleaved in response to multiple death-inducing stimuli (staurosporine, UV radiation, cycloheximide, etoposide).	Staurosporine	82-95	BH3 interacting domain death agonist	Homo sapiens	19-22
11775869-7	2000	Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs.	Staurosporine	27-40	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	100-104
11775869-7	2000	Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs.	Staurosporine	27-40	serpin family E member 1	Homo sapiens	114-119
11775869-7	2000	Curcumin (AP-1 inhibitor), staurosporine (PKC inhibitor), and genistein (PTK inhibitor) all reduced AP-1-mediated PAI-1 mRNA expression induced by thrombin in cultured MCs.	Staurosporine	27-40	coagulation factor II, thrombin	Homo sapiens	147-155
10820172-12	2000	In these cells, the protein kinase C inhibitor staurosporine, but not the protein kinase A inhibitor H89, inhibited the increase in VEGF mRNA induced by 10 nM PTHrP (107-139).	Staurosporine	47-60	vascular endothelial growth factor A	Homo sapiens	132-136
10820172-12	2000	In these cells, the protein kinase C inhibitor staurosporine, but not the protein kinase A inhibitor H89, inhibited the increase in VEGF mRNA induced by 10 nM PTHrP (107-139).	Staurosporine	47-60	parathyroid hormone like hormone	Homo sapiens	159-164
10748026-2	2000	Here we show that beta-catenin is proteolytically cleaved during anoikis and staurosporine-induced apoptosis.	Staurosporine	77-90	catenin beta 1	Homo sapiens	18-30
10811898-11	2000	Additionally, staurosporine-induced, but not NMDA-induced, apoptosis was associated with activation of caspase-8.	Staurosporine	14-27	caspase 8	Homo sapiens	103-112
10809769-5	2000	Here we show that the overexpression of gelsolin inhibits the loss of Deltapsi(m) and cytochrome c release from mitochondria resulting in the lack of activation of caspase-3, -8, and -9 in Jurkat cells treated with staurosporine, thapsigargin, and protoporphyrin IX.	Staurosporine	215-228	gelsolin	Homo sapiens	40-48
10822048-6	2000	Staurosporine, a wide spectrum protein kinase inhibitor, significantly reduced, and N-[N-[N-[2, 6-dimethyl-1piperidinyl)carbonyl]-4-Me-L-Leu]-1-(methoxycarbonyl)- D-t ryptophanyl]-D-norleucine (BQ788), an endothelin ET(B) receptor antagonist, attenuated the down-regulation of endothelin receptors induced by endothelin receptor agonists.	Staurosporine	0-13	endothelin 1	Homo sapiens	205-215
10821340-5	2000	We found that 10 micromol/L serotonin (5-HT) stimulated Mn2+ influx 3-fold, and 1 nmol/L insulin inhibited the 5-HT-stimulated component of Mn2+ influx by 63% (P &lt; .05), but insulin had no effect in the presence of 1 micromol/L staurosporine, an inhibitor of PKC.	Staurosporine	231-244	insulin	Canis lupus familiaris	89-96
10766165-3	2000	This p29 cleaved fragment was detected in Jurkat cells induced to apoptose by anti-Fas antibody, staurosporin, or VP-16.	Staurosporine	97-109	SYF2 pre-mRNA splicing factor	Homo sapiens	5-8
10792618-10	2000	Staurosporin inhibits cell migration and Cdc42GAP aggregation only when added within the first hour, suggesting that it inhibits the stimulatory effect of IGFBP-5201-218 by blocking the IGFBP-5 receptor serine/threonine kinase activity.	Staurosporine	0-12	Rho GTPase activating protein 1	Homo sapiens	41-49
10792618-10	2000	Staurosporin inhibits cell migration and Cdc42GAP aggregation only when added within the first hour, suggesting that it inhibits the stimulatory effect of IGFBP-5201-218 by blocking the IGFBP-5 receptor serine/threonine kinase activity.	Staurosporine	0-12	insulin like growth factor binding protein 5	Homo sapiens	155-162
10744629-3	2000	On induction of apoptosis by staurosporin, c-Myc, etoposide, or ceramide, AIF (but not hsp60) translocates to the nucleus.	Staurosporine	29-41	apoptosis inducing factor mitochondria associated 1	Homo sapiens	74-77
10744629-8	2000	ATP depletion is sufficient to cause AIF translocation to the nucleus, and this phenomenon is accelerated by the apoptosis inducer staurosporin.	Staurosporine	131-143	apoptosis inducing factor mitochondria associated 1	Homo sapiens	37-40
10789557-0	2000	Staurosporine increases carcinoembryonic antigen expression in a human colon cancer cell line.	Staurosporine	0-13	CEA cell adhesion molecule 3	Homo sapiens	24-48
10789557-1	2000	Staurosporine (ST), a protein kinase C inhibitor, was found to produce antitumor effects against C22.20, a clonal subline derived from colon cancer HT-29 line, selected for low expression of carcinoembryonic antigen (CEA).	Staurosporine	0-13	CEA cell adhesion molecule 3	Homo sapiens	191-215
10789557-1	2000	Staurosporine (ST), a protein kinase C inhibitor, was found to produce antitumor effects against C22.20, a clonal subline derived from colon cancer HT-29 line, selected for low expression of carcinoembryonic antigen (CEA).	Staurosporine	0-13	CEA cell adhesion molecule 3	Homo sapiens	217-220
10789557-1	2000	Staurosporine (ST), a protein kinase C inhibitor, was found to produce antitumor effects against C22.20, a clonal subline derived from colon cancer HT-29 line, selected for low expression of carcinoembryonic antigen (CEA).	Staurosporine	15-17	CEA cell adhesion molecule 3	Homo sapiens	191-215
10789557-1	2000	Staurosporine (ST), a protein kinase C inhibitor, was found to produce antitumor effects against C22.20, a clonal subline derived from colon cancer HT-29 line, selected for low expression of carcinoembryonic antigen (CEA).	Staurosporine	15-17	CEA cell adhesion molecule 3	Homo sapiens	217-220
10737619-7	2000	Human Bcl-2 only provided significant neuroprotection against neuronal injury induced by low concentrations of staurosporine (1-10 nM) and H2O2 (0.1-30 microM) and where neuronal death was by apoptosis, but not against H2O2-induced necrosis.	Staurosporine	111-124	BCL2 apoptosis regulator	Homo sapiens	6-11
10737620-4	2000	Upon staurosporine treatment, JNK activity increased six- to sevenfold over the basal level within 2-4 h. Treatment of MN9D/Neo with both staurosporine and a caspase inhibitor, Z-VAD, attenuated cell death without suppressing JNK activation.	Staurosporine	5-18	mitogen-activated protein kinase 8	Mus musculus	30-33
10737620-4	2000	Upon staurosporine treatment, JNK activity increased six- to sevenfold over the basal level within 2-4 h. Treatment of MN9D/Neo with both staurosporine and a caspase inhibitor, Z-VAD, attenuated cell death without suppressing JNK activation.	Staurosporine	5-18	mitogen-activated protein kinase 8	Mus musculus	226-229
10737620-4	2000	Upon staurosporine treatment, JNK activity increased six- to sevenfold over the basal level within 2-4 h. Treatment of MN9D/Neo with both staurosporine and a caspase inhibitor, Z-VAD, attenuated cell death without suppressing JNK activation.	Staurosporine	138-151	mitogen-activated protein kinase 8	Mus musculus	30-33
10737620-4	2000	Upon staurosporine treatment, JNK activity increased six- to sevenfold over the basal level within 2-4 h. Treatment of MN9D/Neo with both staurosporine and a caspase inhibitor, Z-VAD, attenuated cell death without suppressing JNK activation.	Staurosporine	138-151	mitogen-activated protein kinase 8	Mus musculus	226-229
10737620-5	2000	Both staurosporine-induced cell death and JNK activation were attenuated in MN9D/Bcl-2.	Staurosporine	5-18	B cell leukemia/lymphoma 2	Mus musculus	76-86
10737620-7	2000	When cells overexpressing one of the Bcl-2 mutants were treated with staurosporine, death was attenuated in MN9D/BH1, MN9D/BH2, and MN9D/C22 but not in MN9D/BH3 and MN9D/BH4.	Staurosporine	69-82	B cell leukemia/lymphoma 2	Mus musculus	37-42
10737620-7	2000	When cells overexpressing one of the Bcl-2 mutants were treated with staurosporine, death was attenuated in MN9D/BH1, MN9D/BH2, and MN9D/C22 but not in MN9D/BH3 and MN9D/BH4.	Staurosporine	69-82	immunoglobulin kappa variable 1-131	Mus musculus	118-126
10737620-9	2000	Taken together, our data indicate that there exists a close structural and functional correlation of Bcl-2 to JNK and caspase activity in staurosporine-induced dopaminergic neuronal cell death.	Staurosporine	138-151	B cell leukemia/lymphoma 2	Mus musculus	101-106
10737620-9	2000	Taken together, our data indicate that there exists a close structural and functional correlation of Bcl-2 to JNK and caspase activity in staurosporine-induced dopaminergic neuronal cell death.	Staurosporine	138-151	mitogen-activated protein kinase 8	Mus musculus	110-113
10756114-5	2000	Inhibition of PKC activation with either chelerythrine (1 microm) or staurosporine (1 n m) attenuated ET-1-induced increases in DNA synthesis and cell number.	Staurosporine	69-82	endothelin 1	Rattus norvegicus	102-106
10982151-1	2000	Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked by non-isoform specific protein kinase C (PKC) inhibitors, e.g calphostin C, staurosporine.	Staurosporine	170-183	proline rich transmembrane protein 2	Homo sapiens	117-133
10982151-1	2000	Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked by non-isoform specific protein kinase C (PKC) inhibitors, e.g calphostin C, staurosporine.	Staurosporine	170-183	proline rich transmembrane protein 2	Homo sapiens	135-138
10734171-2	2000	When the cells were incubated in the presence of staurosporine (63 nM), phosphorylation of p44/42 MAP kinases and cytosolic phospholipase A(2) (cPLA(2)) was induced at 15 min and increased until 60 min, whereas PGE(2) production and expression of cyclooxygenase-2 (COX-2) protein began to increase at 2 h and increased thereafter.	Staurosporine	49-62	phospholipase A2 group IVA	Rattus norvegicus	91-151
10734171-3	2000	Both PD98059 and U0126, MAP kinase/extracellular signal-regulated kinase (ERK) kinase inhibitors, and LY294002, a PI 3-kinase inhibitor, inhibited staurosporine-induced phosphorylation of p44/42 MAP kinases and cPLA(2) and PGE(2) production.	Staurosporine	147-160	mitogen activated protein kinase 3	Rattus norvegicus	74-77
10734171-3	2000	Both PD98059 and U0126, MAP kinase/extracellular signal-regulated kinase (ERK) kinase inhibitors, and LY294002, a PI 3-kinase inhibitor, inhibited staurosporine-induced phosphorylation of p44/42 MAP kinases and cPLA(2) and PGE(2) production.	Staurosporine	147-160	mitogen activated protein kinase 3	Rattus norvegicus	188-191
10734171-3	2000	Both PD98059 and U0126, MAP kinase/extracellular signal-regulated kinase (ERK) kinase inhibitors, and LY294002, a PI 3-kinase inhibitor, inhibited staurosporine-induced phosphorylation of p44/42 MAP kinases and cPLA(2) and PGE(2) production.	Staurosporine	147-160	phospholipase A2 group IVA	Rattus norvegicus	211-218
10734171-4	2000	Moreover, U0126 inhibited staurosporine-induced arachidonic acid release at 1 h. Although PD98059 and U0126 at 30 microM partially inhibited staurosporine-induced COX-2 protein expression, they completely inhibited staurosporine-induced PGE(2) production.	Staurosporine	26-39	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	163-168
10734171-4	2000	Moreover, U0126 inhibited staurosporine-induced arachidonic acid release at 1 h. Although PD98059 and U0126 at 30 microM partially inhibited staurosporine-induced COX-2 protein expression, they completely inhibited staurosporine-induced PGE(2) production.	Staurosporine	141-154	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	163-168
10734171-4	2000	Moreover, U0126 inhibited staurosporine-induced arachidonic acid release at 1 h. Although PD98059 and U0126 at 30 microM partially inhibited staurosporine-induced COX-2 protein expression, they completely inhibited staurosporine-induced PGE(2) production.	Staurosporine	141-154	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	163-168
10734171-6	2000	In contrast, Ro-31-8220, a PKC inhibitor, completely inhibited staurosporine-induced PGE(2) production and COX-2 protein expression at 8 h but did not inhibit staurosporine-induced phosphorylation of p44/42 MAP kinases and cPLA(2).	Staurosporine	63-76	mitogen activated protein kinase 3	Rattus norvegicus	200-203
10734171-6	2000	In contrast, Ro-31-8220, a PKC inhibitor, completely inhibited staurosporine-induced PGE(2) production and COX-2 protein expression at 8 h but did not inhibit staurosporine-induced phosphorylation of p44/42 MAP kinases and cPLA(2).	Staurosporine	63-76	phospholipase A2 group IVA	Rattus norvegicus	223-230
10760083-10	2000	VLDL-induced MCP-1 expression and monocyte adhesion were blocked by a protein kinase C inhibitor (staurosporine), as well as a calcium channel blocker (diltiazem).	Staurosporine	98-111	CD320 antigen	Mus musculus	0-4
10760083-10	2000	VLDL-induced MCP-1 expression and monocyte adhesion were blocked by a protein kinase C inhibitor (staurosporine), as well as a calcium channel blocker (diltiazem).	Staurosporine	98-111	chemokine (C-C motif) ligand 2	Mus musculus	13-18
10733012-9	2000	Staurosporine inhibited IL-1beta-induced TF activity in the primary astrocytes but did not effect IL-1beta- or TNFalpha-induced TF activity in the astrocytoma cells.	Staurosporine	0-13	interleukin 1 beta	Homo sapiens	24-32
10733012-9	2000	Staurosporine inhibited IL-1beta-induced TF activity in the primary astrocytes but did not effect IL-1beta- or TNFalpha-induced TF activity in the astrocytoma cells.	Staurosporine	0-13	coagulation factor III, tissue factor	Homo sapiens	41-43
10734071-0	2000	Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis.	Staurosporine	115-128	caspase 8	Homo sapiens	0-9
10734071-0	2000	Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis.	Staurosporine	115-128	BH3 interacting domain death agonist	Homo sapiens	25-28
10734071-0	2000	Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis.	Staurosporine	115-128	caspase 3	Homo sapiens	81-90
10762713-4	2000	Cells exposed to staurosporine (0.1 microM) for 30 min showed an increase in caspase 3-activity and by 1 h an increase in PARP 116-kDa band and an 85-kDa cleavage product, which further increased in density with time after treatment.	Staurosporine	17-30	caspase 3	Homo sapiens	77-86
10762713-4	2000	Cells exposed to staurosporine (0.1 microM) for 30 min showed an increase in caspase 3-activity and by 1 h an increase in PARP 116-kDa band and an 85-kDa cleavage product, which further increased in density with time after treatment.	Staurosporine	17-30	poly(ADP-ribose) polymerase 1	Homo sapiens	122-126
10762713-9	2000	Cleavage of lamin B1, a protein important in maintaining the nuclear envelope integrity was observed 12 h after staurosporine treatment.	Staurosporine	112-125	lamin B1	Homo sapiens	12-20
10708590-7	2000	Western analysis showed cleavage of caspase-9, an initiator caspase, of caspase-3, an executioner caspase, and of a caspase substrate, poly-(ADP-ribose)-polymerase (PARP) in staurosporine-treated cells.	Staurosporine	174-187	caspase 9	Homo sapiens	36-45
10708590-7	2000	Western analysis showed cleavage of caspase-9, an initiator caspase, of caspase-3, an executioner caspase, and of a caspase substrate, poly-(ADP-ribose)-polymerase (PARP) in staurosporine-treated cells.	Staurosporine	174-187	caspase 9	Homo sapiens	36-43
10708590-7	2000	Western analysis showed cleavage of caspase-9, an initiator caspase, of caspase-3, an executioner caspase, and of a caspase substrate, poly-(ADP-ribose)-polymerase (PARP) in staurosporine-treated cells.	Staurosporine	174-187	caspase 3	Homo sapiens	72-81
10708590-7	2000	Western analysis showed cleavage of caspase-9, an initiator caspase, of caspase-3, an executioner caspase, and of a caspase substrate, poly-(ADP-ribose)-polymerase (PARP) in staurosporine-treated cells.	Staurosporine	174-187	poly(ADP-ribose) polymerase 1	Homo sapiens	135-163
10708590-7	2000	Western analysis showed cleavage of caspase-9, an initiator caspase, of caspase-3, an executioner caspase, and of a caspase substrate, poly-(ADP-ribose)-polymerase (PARP) in staurosporine-treated cells.	Staurosporine	174-187	poly(ADP-ribose) polymerase 1	Homo sapiens	165-169
10713065-0	2000	Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis.	Staurosporine	43-56	glycogen synthase kinase 3 beta	Homo sapiens	0-30
10713065-3	2000	Staurosporine treatment caused time- and concentration-dependent increases in the activities of caspase-3 and caspase-9 but not caspase-1, increased proteolysis of poly(ADP-ribose) polymerase, and induced morphological changes consistent with apoptosis.	Staurosporine	0-13	caspase 3	Homo sapiens	96-105
10713065-3	2000	Staurosporine treatment caused time- and concentration-dependent increases in the activities of caspase-3 and caspase-9 but not caspase-1, increased proteolysis of poly(ADP-ribose) polymerase, and induced morphological changes consistent with apoptosis.	Staurosporine	0-13	caspase 9	Homo sapiens	110-119
10713065-3	2000	Staurosporine treatment caused time- and concentration-dependent increases in the activities of caspase-3 and caspase-9 but not caspase-1, increased proteolysis of poly(ADP-ribose) polymerase, and induced morphological changes consistent with apoptosis.	Staurosporine	0-13	caspase 1	Homo sapiens	128-137
10713065-3	2000	Staurosporine treatment caused time- and concentration-dependent increases in the activities of caspase-3 and caspase-9 but not caspase-1, increased proteolysis of poly(ADP-ribose) polymerase, and induced morphological changes consistent with apoptosis.	Staurosporine	0-13	poly(ADP-ribose) polymerase 1	Homo sapiens	164-191
10713065-4	2000	Overexpression of glycogen synthase kinase-3beta to levels 3.5 times that in control cells did not alter basal indices of apoptosis but potentiated staurosporine-induced activation of caspase-3, caspase-9, proteolysis of poly(ADP-ribose) polymerase, and morphological changes indicative of apoptosis.	Staurosporine	148-161	glycogen synthase kinase 3 beta	Homo sapiens	18-48
10713065-4	2000	Overexpression of glycogen synthase kinase-3beta to levels 3.5 times that in control cells did not alter basal indices of apoptosis but potentiated staurosporine-induced activation of caspase-3, caspase-9, proteolysis of poly(ADP-ribose) polymerase, and morphological changes indicative of apoptosis.	Staurosporine	148-161	caspase 3	Homo sapiens	184-193
10713065-4	2000	Overexpression of glycogen synthase kinase-3beta to levels 3.5 times that in control cells did not alter basal indices of apoptosis but potentiated staurosporine-induced activation of caspase-3, caspase-9, proteolysis of poly(ADP-ribose) polymerase, and morphological changes indicative of apoptosis.	Staurosporine	148-161	caspase 9	Homo sapiens	195-204
10713065-4	2000	Overexpression of glycogen synthase kinase-3beta to levels 3.5 times that in control cells did not alter basal indices of apoptosis but potentiated staurosporine-induced activation of caspase-3, caspase-9, proteolysis of poly(ADP-ribose) polymerase, and morphological changes indicative of apoptosis.	Staurosporine	148-161	poly(ADP-ribose) polymerase 1	Homo sapiens	221-248
10713065-5	2000	Inhibition of glycogen synthase kinase-3beta by lithium attenuated the enhanced staurosporine-induced activation of caspase-3 in cells overexpressing glycogen synthase kinase-3beta.	Staurosporine	80-93	glycogen synthase kinase 3 beta	Homo sapiens	14-44
10713065-5	2000	Inhibition of glycogen synthase kinase-3beta by lithium attenuated the enhanced staurosporine-induced activation of caspase-3 in cells overexpressing glycogen synthase kinase-3beta.	Staurosporine	80-93	caspase 3	Homo sapiens	116-125
10713065-5	2000	Inhibition of glycogen synthase kinase-3beta by lithium attenuated the enhanced staurosporine-induced activation of caspase-3 in cells overexpressing glycogen synthase kinase-3beta.	Staurosporine	80-93	glycogen synthase kinase 3 beta	Homo sapiens	150-180
10694448-7	2000	Staurosporine treatment enhanced chondrogenesis in micromass culture by inducing a rapid quantitative increase in Sox9 transcript levels.	Staurosporine	0-13	SRY-box 9	Gallus gallus	114-118
10644754-7	2000	The activity of the serine 3 cofilin kinase was insensitive to a variety of selective antagonists of protein kinases but was blocked by staurosporine.	Staurosporine	136-149	cofilin 1	Homo sapiens	29-36
10763823-0	2000	Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.	Staurosporine	41-54	epidermal growth factor	Homo sapiens	0-23
10763823-0	2000	Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.	Staurosporine	41-54	epidermal growth factor	Homo sapiens	25-28
10763823-0	2000	Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway.	Staurosporine	41-54	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	85-90
10763823-2	2000	In addition to mitogenic ability, we demonstrate in this report that EGF protects a human esophageal carcinoma (CE) cell line, CE81T/VGH, from staurosporine-induced apoptosis.	Staurosporine	143-156	epidermal growth factor	Homo sapiens	69-72
10763823-4	2000	Furthermore, v-raf blocks apoptosis induced by staurosporine.	Staurosporine	47-60	zinc fingers and homeoboxes 2	Homo sapiens	15-18
10888033-1	2000	The staurosporine derivative PKC412 was originally identified as an inhibitor of protein kinase C (PKC) and subsequently shown to inhibit other kinases including the kinase insert domain receptor (KDR) (vascular endothelial growth factor receptor, VEGF-R2), the receptor of platelet-derived growth factor, and the receptor for the stem cell factor, c-kit.	Staurosporine	4-17	kinase insert domain protein receptor	Mus musculus	166-195
10888033-1	2000	The staurosporine derivative PKC412 was originally identified as an inhibitor of protein kinase C (PKC) and subsequently shown to inhibit other kinases including the kinase insert domain receptor (KDR) (vascular endothelial growth factor receptor, VEGF-R2), the receptor of platelet-derived growth factor, and the receptor for the stem cell factor, c-kit.	Staurosporine	4-17	kinase insert domain protein receptor	Mus musculus	197-200
10888033-1	2000	The staurosporine derivative PKC412 was originally identified as an inhibitor of protein kinase C (PKC) and subsequently shown to inhibit other kinases including the kinase insert domain receptor (KDR) (vascular endothelial growth factor receptor, VEGF-R2), the receptor of platelet-derived growth factor, and the receptor for the stem cell factor, c-kit.	Staurosporine	4-17	kinase insert domain protein receptor	Mus musculus	248-255
10888033-1	2000	The staurosporine derivative PKC412 was originally identified as an inhibitor of protein kinase C (PKC) and subsequently shown to inhibit other kinases including the kinase insert domain receptor (KDR) (vascular endothelial growth factor receptor, VEGF-R2), the receptor of platelet-derived growth factor, and the receptor for the stem cell factor, c-kit.	Staurosporine	4-17	kit ligand	Mus musculus	331-347
10888033-1	2000	The staurosporine derivative PKC412 was originally identified as an inhibitor of protein kinase C (PKC) and subsequently shown to inhibit other kinases including the kinase insert domain receptor (KDR) (vascular endothelial growth factor receptor, VEGF-R2), the receptor of platelet-derived growth factor, and the receptor for the stem cell factor, c-kit.	Staurosporine	4-17	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	349-354
10679579-3	2000	Two phorbol esters, 4-beta-phorbol 12-myristate-13-acetate (PMA) and 4-beta-phorbol 12,13-dibutyrate (PDBu); the cGMP-dependent PK activators sodium nitroprusside (SNP) and S-nitrosoglutathione (SNOG); and the PP inhibitor okadaic acid (OA) reduced the amplitude of the GABA-induced currents, whilst the PK inhibitor staurosporine potentiated it.	Staurosporine	317-330	cyclin-dependent kinase 2 S homeolog	Xenopus laevis	128-130
10670466-4	2000	Staurosporine, an inhibitor of PKC, completely reversed the effect of PMA.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	31-34
10639334-8	2000	Staurosporine, a direct inhibitor of PAK2, largely prevented the action of microinjected PAK2 in endothelial cells.	Staurosporine	0-13	p21 (RAC1) activated kinase 2	Homo sapiens	37-41
10639334-8	2000	Staurosporine, a direct inhibitor of PAK2, largely prevented the action of microinjected PAK2 in endothelial cells.	Staurosporine	0-13	p21 (RAC1) activated kinase 2	Homo sapiens	89-93
10708546-5	2000	The phosphorylation of 45-kDa protein induced by cystathionine ketimine and NAc-OCPC was inhibited by genistein and herbimycin A, inhibitors of tyrosine kinase, but was not inhibited by H-7 and staurosporine, inhibitors of protein kinase C. Cystathionine metabolites and l-cystathionine sulfoxides were separated into two diastereoisomers, CS-I and CS-II.	Staurosporine	194-207	X-linked Kx blood group	Homo sapiens	76-79
10700604-0	2000	S-100beta protects cultured neurons against glutamate- and staurosporine-induced damage and is involved in the antiapoptotic action of the 5 HT(1A)-receptor agonist, Bay x 3702.	Staurosporine	59-72	S100 calcium binding protein B	Rattus norvegicus	0-9
10700604-17	2000	Extracellularly added S-100beta (1-10 ng/ml) reduced staurosporine-induced damage in pure neuronal cultures from chick embryo telencephalon as well as in mixed neuronal/glial cultures from neonatal rat hippocampus.	Staurosporine	53-66	S100 calcium binding protein B	Gallus gallus	22-31
10700604-25	2000	Thus, we conclude that S-100beta was able to protect cultured neurons against glutamate- and staurosporine-induced damage.	Staurosporine	93-106	S100 calcium binding protein B	Rattus norvegicus	23-32
10700604-26	2000	Furthermore, S-100beta mediated partially the protective effect of the 5-HT(1A) receptor agonist, Bay x 3702, against staurosporine-induced apoptosis in mixed neuronal/glial cultures from neonatal rat hippocampus.	Staurosporine	118-131	S100 calcium binding protein B	Rattus norvegicus	13-22
10696073-9	2000	The tyrosine kinase inhibitor genistein and the protein kinase C inhibitor staurosporine blocked TCDD-elicited induction of CYP1A1, but they did not affect CYP1B1 induction.	Staurosporine	75-88	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	124-130
10686577-4	2000	p130cas was also degraded in cells treated with staurosporine or etoposide, suggesting that degradation of focal adhesion proteins is a characteristic feature of apoptosis.	Staurosporine	48-61	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	0-7
10728681-5	2000	Apoptosis could be induced in cell lines that overexpressed Bcl-2 or Bcl-XL when the cells were treated with anti-Fas antibody, tumor necrosis factor alpha, staurosporine, or Bax, in addition to TC-A.	Staurosporine	157-170	BCL2 apoptosis regulator	Homo sapiens	60-65
10728681-5	2000	Apoptosis could be induced in cell lines that overexpressed Bcl-2 or Bcl-XL when the cells were treated with anti-Fas antibody, tumor necrosis factor alpha, staurosporine, or Bax, in addition to TC-A.	Staurosporine	157-170	BCL2 like 1	Homo sapiens	69-75
10719304-13	2000	GQ1b-induced increases in IL-6 and IL-10 production of T cells were both blocked by PKC inhibitors, calphostin C and staurosporine.	Staurosporine	117-130	interleukin 6	Homo sapiens	26-30
10719304-13	2000	GQ1b-induced increases in IL-6 and IL-10 production of T cells were both blocked by PKC inhibitors, calphostin C and staurosporine.	Staurosporine	117-130	interleukin 10	Homo sapiens	35-40
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Staurosporine	73-86	formyl peptide receptor 1	Homo sapiens	109-113
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Staurosporine	73-86	selectin L	Homo sapiens	165-175
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Staurosporine	73-86	formyl peptide receptor 1	Homo sapiens	227-231
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Staurosporine	73-86	integrin subunit alpha M	Homo sapiens	257-262
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Staurosporine	73-86	integrin subunit alpha M	Homo sapiens	264-269
10733103-4	2000	We found that three selective inhibitors of PKC, structurally related to staurosporine, largely blocked both fMLP- and phorbol 12-myristate 13-acetate (PMA)-induced L-selectin shedding; however, these inhibitors did not affect fMLP-induced up-regulation of Mac-1 (CD11b/CD18) expression, which has been shown not to involve PKC.	Staurosporine	73-86	integrin subunit beta 2	Homo sapiens	270-274
10775801-6	2000	On the contrary, stimulation of AP1 proteins by the tumor-promoting phorbol ester caused a decrease in androgen-induced mvdp mRNA accumulation, and this effect was reversed by staurosporine, a potent inhibitor of PKC.	Staurosporine	176-189	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-35
10684732-9	2000	Moreover, BAECs exposed to the PKC inhibitor, staurosporine (50 ng/ml), exhibited significant attenuation of VEGF-induced increase in L(p), but inhibition of nitric oxide synthase (NOS) with L-NMMA (100 microM) had no effect in altering the VEGF-induced increase in L(p).	Staurosporine	46-59	vascular endothelial growth factor A	Bos taurus	109-113
10684732-9	2000	Moreover, BAECs exposed to the PKC inhibitor, staurosporine (50 ng/ml), exhibited significant attenuation of VEGF-induced increase in L(p), but inhibition of nitric oxide synthase (NOS) with L-NMMA (100 microM) had no effect in altering the VEGF-induced increase in L(p).	Staurosporine	46-59	vascular endothelial growth factor A	Bos taurus	241-245
10692481-0	2000	Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene.	Staurosporine	35-48	nitric oxide synthase 3	Homo sapiens	85-118
10679755-0	2000	Heterogeneous apoptotic responses of prostate cancer cell lines identify an association between sensitivity to staurosporine-induced apoptosis, expression of Bcl-2 family members, and caspase activation.	Staurosporine	111-124	BCL2 apoptosis regulator	Homo sapiens	158-163
10679755-3	2000	RESULTS: The LNCaP and TsuPr(1) lines exhibited quintessential apoptotic features in response to the pleiotropic apoptotic inducer staurosporine (STS): rapid cytochrome c translocation to the cytosol, proteolytic processing and catalytic activation of caspase-3 and -7, proteolytic inactivation of the death substrates DNA fragmentation factor (DFF) and poly-ADP-ribose polymerase (PARP), and TUNEL-positive polyfragmented nuclei.	Staurosporine	131-144	cytochrome c, somatic	Homo sapiens	158-170
10679755-3	2000	RESULTS: The LNCaP and TsuPr(1) lines exhibited quintessential apoptotic features in response to the pleiotropic apoptotic inducer staurosporine (STS): rapid cytochrome c translocation to the cytosol, proteolytic processing and catalytic activation of caspase-3 and -7, proteolytic inactivation of the death substrates DNA fragmentation factor (DFF) and poly-ADP-ribose polymerase (PARP), and TUNEL-positive polyfragmented nuclei.	Staurosporine	131-144	caspase 3	Homo sapiens	252-268
10679755-3	2000	RESULTS: The LNCaP and TsuPr(1) lines exhibited quintessential apoptotic features in response to the pleiotropic apoptotic inducer staurosporine (STS): rapid cytochrome c translocation to the cytosol, proteolytic processing and catalytic activation of caspase-3 and -7, proteolytic inactivation of the death substrates DNA fragmentation factor (DFF) and poly-ADP-ribose polymerase (PARP), and TUNEL-positive polyfragmented nuclei.	Staurosporine	131-144	poly(ADP-ribose) polymerase 1	Homo sapiens	354-380
10679755-3	2000	RESULTS: The LNCaP and TsuPr(1) lines exhibited quintessential apoptotic features in response to the pleiotropic apoptotic inducer staurosporine (STS): rapid cytochrome c translocation to the cytosol, proteolytic processing and catalytic activation of caspase-3 and -7, proteolytic inactivation of the death substrates DNA fragmentation factor (DFF) and poly-ADP-ribose polymerase (PARP), and TUNEL-positive polyfragmented nuclei.	Staurosporine	131-144	poly(ADP-ribose) polymerase 1	Homo sapiens	382-386
10681443-5	2000	Neuronal expression of the p35 protein was found to confer functional caspase inhibitory activity and prevent apoptosis in isolated cerebellar granular cultures induced to undergo apoptosis either via staurosporine treatment or through withdrawal of extracellular potassium.	Staurosporine	201-214	interleukin 12a	Mus musculus	27-30
10662600-9	2000	Staurosporine, a nonselective inhibitor of protein kinase C (PKC), inhibited PCB-induced release of [(3)H]-AA.	Staurosporine	0-13	protein kinase C, alpha	Rattus norvegicus	61-64
10662600-9	2000	Staurosporine, a nonselective inhibitor of protein kinase C (PKC), inhibited PCB-induced release of [(3)H]-AA.	Staurosporine	0-13	pyruvate carboxylase	Rattus norvegicus	77-80
10677502-0	2000	Survival function of ERK1/2 as IL-3-activated, staurosporine-resistant Bcl2 kinases.	Staurosporine	47-60	mitogen-activated protein kinase 3	Homo sapiens	21-27
10677502-2	2000	Paradoxically, expression of exogenous Bcl2 can protect parental cells from apoptosis induced by the potent PKC inhibitor, staurosporine (stauro).	Staurosporine	123-136	BCL2 apoptosis regulator	Homo sapiens	39-43
10677502-2	2000	Paradoxically, expression of exogenous Bcl2 can protect parental cells from apoptosis induced by the potent PKC inhibitor, staurosporine (stauro).	Staurosporine	123-129	BCL2 apoptosis regulator	Homo sapiens	39-43
10677502-3	2000	High concentrations of stauro of up to 1 microM only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKC-mediated Bcl2 phosphorylation in vitro.	Staurosporine	23-29	interleukin 3	Homo sapiens	71-75
10677502-3	2000	High concentrations of stauro of up to 1 microM only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKC-mediated Bcl2 phosphorylation in vitro.	Staurosporine	23-29	BCL2 apoptosis regulator	Homo sapiens	87-91
10677502-3	2000	High concentrations of stauro of up to 1 microM only partially inhibit IL-3-stimulated Bcl2 phosphorylation but completely block PKC-mediated Bcl2 phosphorylation in vitro.	Staurosporine	23-29	BCL2 apoptosis regulator	Homo sapiens	142-146
10677502-6	2000	A role for a MEK/MAPK as a responsible SRK was implicated because the highly specific MEK/MAPK inhibitor, PD98059, also can only partially inhibit IL-3-induced Bcl2 phosphorylation, whereas the combination of PD98059 and stauro completely blocks phosphorylation and synergistically enhances apoptosis.	Staurosporine	221-227	mitogen-activated protein kinase kinase 7	Homo sapiens	13-16
10677502-6	2000	A role for a MEK/MAPK as a responsible SRK was implicated because the highly specific MEK/MAPK inhibitor, PD98059, also can only partially inhibit IL-3-induced Bcl2 phosphorylation, whereas the combination of PD98059 and stauro completely blocks phosphorylation and synergistically enhances apoptosis.	Staurosporine	221-227	ribosomal protein S6 kinase B2	Homo sapiens	39-42
10627456-8	2000	The PKC inhibitors staurosporine and calphostin C prevented EPO-induced erythroid differentiation.	Staurosporine	19-32	protein kinase C alpha	Homo sapiens	4-7
10627456-8	2000	The PKC inhibitors staurosporine and calphostin C prevented EPO-induced erythroid differentiation.	Staurosporine	19-32	erythropoietin	Homo sapiens	60-63
10617637-8	2000	The mRNA up-regulation by MIF was inhibited by the tyrosine kinase inhibitors genestein and herbimycin A, as well as the protein kinase C inhibitors staurosporine and H-7.	Staurosporine	149-162	macrophage migration inhibitory factor	Homo sapiens	26-29
10663630-7	2000	Caspase-3 activity increased more than 20-fold in cells treated with actinomycin D, staurosporine, or cisplatin but increased less than fivefold in ACNU-treated cells.	Staurosporine	84-97	caspase 3	Homo sapiens	0-9
10672898-2	2000	Similar to the parental cells, a mutant clone, M-NRP1, expressed TGF-beta receptors and was still responsive to induction both of direct target genes by TGF-beta and of apoptosis by staurosporine or okadaic acid.	Staurosporine	182-195	neuropilin 1	Rattus norvegicus	49-53
10713725-3	2000	In this report we demonstrate by subcellular fractionation a significant shift in Bax localization from cytosol to cellular membranes in two human tumor cell lines exposed to staurosporine or etoposide.	Staurosporine	175-188	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
10713725-7	2000	High level overexpression of the anti-apoptotic protein Bcl-2 prevented Bax redistribution to the mitochondria, caspase activation and apoptosis following exposure to staurosporine or etoposide.	Staurosporine	167-180	BCL2 apoptosis regulator	Homo sapiens	56-61
10713725-7	2000	High level overexpression of the anti-apoptotic protein Bcl-2 prevented Bax redistribution to the mitochondria, caspase activation and apoptosis following exposure to staurosporine or etoposide.	Staurosporine	167-180	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
10875891-2	2000	Modulation of the HGF/SF-induced migration process by staurosporine, an inhibitor of protein kinase C (PKC), was also examined.	Staurosporine	54-67	hepatocyte growth factor	Canis lupus familiaris	18-24
10875891-6	2000	Blocking PKC activation during HGF/SF treatment with staurosporine inhibited cell spreading, and the cells retained barmotin/7H6 expression until at 6 h after HGF/SF treatment.	Staurosporine	53-66	hepatocyte growth factor	Canis lupus familiaris	31-37
10964450-4	2000	Staurosporine, a general kinase inhibitor, resulted in a 40% lowering of phosphorylation of LDLR/LRP, but did not give rise to measurable changes in its membrane traffic in MDCK cells.	Staurosporine	0-13	low density lipoprotein receptor	Canis lupus familiaris	92-96
10652248-3	2000	We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2.	Staurosporine	31-44	caspase 3	Mus musculus	173-182
10652248-3	2000	We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2.	Staurosporine	31-44	caspase 2	Mus musculus	187-196
10652248-3	2000	We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2.	Staurosporine	46-48	caspase 3	Mus musculus	173-182
10652248-3	2000	We now show that HS, 4-CP, and staurosporine (ST) induce the release of cytochrome c from mitochondria with kinetics suggesting a causal relationship with the activation of caspase-3 and caspase-2.	Staurosporine	46-48	caspase 2	Mus musculus	187-196
10657432-4	2000	METHODS: PD-98059, damnacanthal, wortmannin, AG-490, genistein, calphostin C, and staurosporine were used to inhibit, or relax, the ET-1-induced contraction of basilar artery, studied with an isometric tension system.	Staurosporine	82-95	endothelin-1	Oryctolagus cuniculus	132-136
10657432-9	2000	(4) The PKC inhibitor staurosporine but not calphostin C abolished ET-1-induced contraction, and the PTK inhibitor genistein partially reduced ET-1-induced contraction.	Staurosporine	22-35	endothelin-1	Oryctolagus cuniculus	67-71
10657432-10	2000	(5) In arteries precontracted by ET-1, PD-98059, U-0126, wortmannin, AG-490, genistein, and staurosporine produced concentration-dependent relaxation.	Staurosporine	92-105	endothelin-1	Oryctolagus cuniculus	33-37
10657704-5	2000	Treatment of telencephalic cells with the broad caspase inhibitor BAF, blocked caspase-3 activation and protected cells against both AraC and staurosporine-induced apoptotic death.	Staurosporine	142-155	b-associated fitness	Mus musculus	66-69
11920174-7	2000	QBEND10-induced aggregation of KG1a and CD34-positive cells was enhanced by staurosporine (a protein kinase C inhibitor) and inhibited by genistein (a protein tyrosine kinase inhibitor).	Staurosporine	76-89	CD34 molecule	Homo sapiens	40-44
10964450-4	2000	Staurosporine, a general kinase inhibitor, resulted in a 40% lowering of phosphorylation of LDLR/LRP, but did not give rise to measurable changes in its membrane traffic in MDCK cells.	Staurosporine	0-13	major vault protein	Canis lupus familiaris	97-100
12845746-3	2000	In contrast, staurosporine exerted a variable inhibitory effect on GH release.	Staurosporine	13-26	growth hormone 1	Homo sapiens	67-69
11215053-4	2000	The numbers of the cultured meningioma cells were counted to evaluate the effect of the PKC inhibitor staurosporine on proliferation of meningioma cells.	Staurosporine	102-115	proline rich transmembrane protein 2	Homo sapiens	88-91
11920197-9	2000	Staurosporine (5 microM) inhibited O(2)-stimulated glycine transport through system ASC.	Staurosporine	0-13	PYD and CARD domain containing	Homo sapiens	84-87
10585882-4	1999	The pretreatment of HL-60 cells with staurosporine, chelerythrine chloride and bisindolylmaleimide abolished the activity of sphingomyelinase in response to 1,25(OH)(2)D(3) and IFN-gamma.	Staurosporine	37-50	interferon gamma	Homo sapiens	177-186
10600161-10	1999	Staurosporin inhibited the anti-LRP antibody-induced increase in PKC activity.	Staurosporine	0-12	LDL receptor related protein 1	Homo sapiens	32-35
10716204-7	1999	However, unlike dbcAMP and staurosporine, which also induce fra-1, HMBA repressed cycloheximide-induced fra-1 gene expression.	Staurosporine	27-40	FOS like 1, AP-1 transcription factor subunit	Rattus norvegicus	60-65
10574973-7	1999	Withdrawal of serum and of macrophage colony stimulating factor, necessary for survival of purified osteoclasts, or treatment with staurosporine also induce apoptosis and caspase cleavage of Mst1.	Staurosporine	131-144	macrophage stimulating 1	Homo sapiens	191-195
10600773-8	1999	KCC3 transiently expressed in human embryonic kidney (HEK)-293 cells fulfilled three criteria for increased expression of K-Cl cotransport: stimulation of cotransport by swelling, treatment with N-ethylmaleimide, or treatment with staurosporine.	Staurosporine	231-244	solute carrier family 12 member 6	Homo sapiens	0-4
10600794-5	1999	Both staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the ET-1-induced HSP 27 accumulation.	Staurosporine	5-18	endothelin 1	Mus musculus	90-94
10600794-5	1999	Both staurosporine and calphostin C, inhibitors of protein kinase C (PKC), suppressed the ET-1-induced HSP 27 accumulation.	Staurosporine	5-18	heat shock protein 1	Mus musculus	103-109
10698260-0	1999	Both low and high concentrations of staurosporine induce G1 arrest through down-regulation of cyclin E and cdk2 expression.	Staurosporine	36-49	cyclin dependent kinase 2	Homo sapiens	107-111
10698260-5	1999	However, 200 nM staurosporine increased the expression of cyclin B and cdc2 proteins, suggesting that the cells progressed through the G2/M transition, and increased the expression of MPM2 protein, indicating that the cells entered M phase.	Staurosporine	16-29	cyclin dependent kinase 1	Homo sapiens	71-75
10698260-5	1999	However, 200 nM staurosporine increased the expression of cyclin B and cdc2 proteins, suggesting that the cells progressed through the G2/M transition, and increased the expression of MPM2 protein, indicating that the cells entered M phase.	Staurosporine	16-29	forkhead box M1	Mus musculus	184-188
10698260-6	1999	Moreover, 200 nM staurosporine increased the expression of p53 and p21 proteins and inhibited the expression of cyclin E and cdk2 proteins, suggesting that the cells were arrested in the G1 phase of the next cycle.	Staurosporine	17-30	tumor protein p53	Homo sapiens	59-62
10698260-6	1999	Moreover, 200 nM staurosporine increased the expression of p53 and p21 proteins and inhibited the expression of cyclin E and cdk2 proteins, suggesting that the cells were arrested in the G1 phase of the next cycle.	Staurosporine	17-30	cyclin dependent kinase inhibitor 1A	Homo sapiens	67-70
10698260-6	1999	Moreover, 200 nM staurosporine increased the expression of p53 and p21 proteins and inhibited the expression of cyclin E and cdk2 proteins, suggesting that the cells were arrested in the G1 phase of the next cycle.	Staurosporine	17-30	cyclin dependent kinase 2	Homo sapiens	125-129
10583383-11	1999	In vitro, enovin stimulates neurite outgrowth and counteracts taxol-induced neurotoxicity in staurosporine-differentiated SH-SY5Y human neuroblastoma cells.	Staurosporine	93-106	artemin	Homo sapiens	10-16
11139839-8	1999	New agents such as the staurosporine analogue UCN-01 and bryostatin are thought to affect apoptosis induction by altering BCL-2 phosphorylation.	Staurosporine	23-36	BCL2 apoptosis regulator	Homo sapiens	122-127
10559783-12	1999	Whereas the protein kinase C (PKC) inhibitors staurosporine and chelerythrine chloride had a stimulatory effect on NT-3-promoted process formation, the tyrosine kinase inhibitor genistein had an inhibitory effect and mainly cells with a bipolar and immature morphology were observable.	Staurosporine	46-59	neurotrophin 3	Rattus norvegicus	115-119
10593613-8	1999	Staurosporine decreased both ODC activity and PKC activity, while DFMO had no effect on PKC activity.	Staurosporine	0-13	ornithine decarboxylase 1	Rattus norvegicus	29-32
10589684-7	1999	However, calcitonin-induced CYP27B1 mRNA expression was only inhibited by the protein kinase C inhibitors staurosporine and calphostin C.	Staurosporine	106-119	cytochrome P450 family 27 subfamily B member 1	Sus scrofa	28-35
10574705-2	1999	TGF-(beta)1, but not activin A or osteogenic protein-1 (OP-1)/bone morphogenetic protein-7 (BMP-7), was able to induce morphological transformation of NMuMG cells as shown by reorganisation of the actin cytoskeleton and relocalisation/downregulation of E-cadherin and (beta)-catenin, an effect that was abrogated by the more general serine/threonine kinase and protein kinase C inhibitor, staurosporine.	Staurosporine	389-402	transforming growth factor, beta 1	Mus musculus	0-11
10582585-0	1999	Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer"s disease mutations in human neuroglioma cells.	Staurosporine	0-13	caspase 3	Homo sapiens	36-45
10582585-0	1999	Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer"s disease mutations in human neuroglioma cells.	Staurosporine	0-13	presenilin 1	Homo sapiens	64-76
10582585-5	1999	Staurosporine treatment of these cells resulted in increased cell death and up to a 10-fold increase in caspase-3 activation in mutant versus wt PS1-expressing cell lines.	Staurosporine	0-13	caspase 3	Homo sapiens	104-113
10582585-5	1999	Staurosporine treatment of these cells resulted in increased cell death and up to a 10-fold increase in caspase-3 activation in mutant versus wt PS1-expressing cell lines.	Staurosporine	0-13	presenilin 1	Homo sapiens	145-148
10565839-5	1999	Whereas the PKC inhibitor staurosporine (3 microM) inhibited ERK activation by NPY, the chemically distinct PKC inhibitors calphostin C (3 microM), Go 6976 (3 microM), and bisindolylmaleimide I (3 microM) did not.	Staurosporine	26-39	proline rich transmembrane protein 2	Homo sapiens	12-15
10565839-5	1999	Whereas the PKC inhibitor staurosporine (3 microM) inhibited ERK activation by NPY, the chemically distinct PKC inhibitors calphostin C (3 microM), Go 6976 (3 microM), and bisindolylmaleimide I (3 microM) did not.	Staurosporine	26-39	mitogen-activated protein kinase 1	Homo sapiens	61-64
10565839-5	1999	Whereas the PKC inhibitor staurosporine (3 microM) inhibited ERK activation by NPY, the chemically distinct PKC inhibitors calphostin C (3 microM), Go 6976 (3 microM), and bisindolylmaleimide I (3 microM) did not.	Staurosporine	26-39	neuropeptide Y	Homo sapiens	79-82
10565839-9	1999	Staurosporine may have PKC-independent effects on ERK activation.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	23-26
10565839-9	1999	Staurosporine may have PKC-independent effects on ERK activation.	Staurosporine	0-13	mitogen-activated protein kinase 1	Homo sapiens	50-53
10652129-7	1999	Moreover, induction of accumulation of the mRNA for ERF2 was inhibited by staurosporine and calyculin A.	Staurosporine	74-87	ethylene-responsive transcription factor 2	Nicotiana tabacum	52-56
10581530-6	1999	Cleavage of poly(ADP-ribose) polymerase (PARP) illustrated that the staurosporine treatment induced apoptosis in the cells within 6 h. Analysis of PARP cleavage indicated that treatment with DFMO accelerated the kinetics of progression of apoptosis but did not influence the sensitivity of cells to 10 nM-1 microM staurosporine.	Staurosporine	68-81	poly(ADP-ribose) polymerase 1	Homo sapiens	12-39
10581530-6	1999	Cleavage of poly(ADP-ribose) polymerase (PARP) illustrated that the staurosporine treatment induced apoptosis in the cells within 6 h. Analysis of PARP cleavage indicated that treatment with DFMO accelerated the kinetics of progression of apoptosis but did not influence the sensitivity of cells to 10 nM-1 microM staurosporine.	Staurosporine	68-81	poly(ADP-ribose) polymerase 1	Homo sapiens	41-45
10581530-6	1999	Cleavage of poly(ADP-ribose) polymerase (PARP) illustrated that the staurosporine treatment induced apoptosis in the cells within 6 h. Analysis of PARP cleavage indicated that treatment with DFMO accelerated the kinetics of progression of apoptosis but did not influence the sensitivity of cells to 10 nM-1 microM staurosporine.	Staurosporine	68-81	poly(ADP-ribose) polymerase 1	Homo sapiens	147-151
10567423-2	1999	During apoptosis of the human T-cell line, Jurkat cells, as induced by staurosporine or Fas ligation, IP(3)R type 1 (IP(3)R1) was found to be cleaved.	Staurosporine	71-84	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	102-124
10567423-7	1999	Tumor necrosis factor-alpha- or staurosporine-induced apoptosis in caspase-3-deficient MCF-7 cells failed to demonstrate cleavage of IP(3)R1.	Staurosporine	32-45	caspase 3	Homo sapiens	67-76
10559201-4	1999	Overexpression of the anti-apoptosis protein Bcl-2 led to increased Ca(m) load, increased mitochondrial membrane potential (DeltaPsi(m)), and inhibition of staurosporine-induced apoptosis.	Staurosporine	156-169	BCL2 apoptosis regulator	Homo sapiens	45-50
10551820-7	1999	Two natural compounds, quercetin and staurosporine, had previously been shown to inhibit the NF-kappaB pathway, but the molecular target(s) of these compounds in the event had not been established.	Staurosporine	37-50	nuclear factor kappa B subunit 1	Homo sapiens	93-102
10551820-8	1999	Here we demonstrate that quercetin and staurosporine potently inhibit both IKKalpha and IKKbeta.	Staurosporine	39-52	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	75-83
10551820-8	1999	Here we demonstrate that quercetin and staurosporine potently inhibit both IKKalpha and IKKbeta.	Staurosporine	39-52	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	88-95
10551820-10	1999	This suggests that the inhibitory properties of quercetin and staurosporine in the NF-kappaB pathway are mediated in part by their inhibition of IKKalpha and IKKbeta.	Staurosporine	62-75	nuclear factor kappa B subunit 1	Homo sapiens	83-92
10551820-10	1999	This suggests that the inhibitory properties of quercetin and staurosporine in the NF-kappaB pathway are mediated in part by their inhibition of IKKalpha and IKKbeta.	Staurosporine	62-75	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	145-153
10551820-10	1999	This suggests that the inhibitory properties of quercetin and staurosporine in the NF-kappaB pathway are mediated in part by their inhibition of IKKalpha and IKKbeta.	Staurosporine	62-75	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	158-165
10551820-12	1999	The strong inhibition of IKKbeta by staurosporine (K(i) = 172 nM) and ADP (K(i) = 136 nM) provides a rationale and structural framework for designing potent ATP-site inhibitors of IKKbeta, which is an attractive drug target for inflammatory diseases.	Staurosporine	36-49	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	25-32
10551820-12	1999	The strong inhibition of IKKbeta by staurosporine (K(i) = 172 nM) and ADP (K(i) = 136 nM) provides a rationale and structural framework for designing potent ATP-site inhibitors of IKKbeta, which is an attractive drug target for inflammatory diseases.	Staurosporine	36-49	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	180-187
10542243-1	1999	Expression of the pleiotropic cytokine interleukin (IL)-6 can be stimulated by the proinflammatory cytokine tumor necrosis factor (TNF) and the microbial alkaloid staurosporine (STS).	Staurosporine	178-181	tumor necrosis factor	Homo sapiens	131-134
10544013-8	1999	Induction of HB-EGF by TGFbeta1 was not affected by pretreatment with the MEK inhibitor PD-98059 while inhibition of protein kinase C either partially (calphostin C) or completely (staurosporin) blocked induction.	Staurosporine	181-193	heparin binding EGF like growth factor	Homo sapiens	13-19
10578141-4	1999	These increases were reduced or eliminated by pretreatment of the cells with the PKC antagonists staurosporine or GF 109203X or the NO scavenger, phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO).	Staurosporine	97-110	protein kinase C, alpha	Rattus norvegicus	81-84
10514472-6	1999	Upon staurosporine treatment, cytochrome c was released concomitantly with activation of caspase 3 and loss of mitochondrial membrane potential (Deltapsi(m)).	Staurosporine	5-18	cytochrome c, somatic	Homo sapiens	30-42
10598880-0	1999	Activation of cellular responses to interleukin 6 is blocked by staurosporine.	Staurosporine	64-77	interleukin 6	Homo sapiens	36-49
10598880-2	1999	The effects of the microbial alkaloid staurosporine (SS) on IL-6 signaling through gp130, and also on the internalization of the IL-6 receptor complex, were studied using HepG2 cells which are well-characterized in their ability to respond to IL-6 by upregulating acute-phase protein production.	Staurosporine	53-55	interleukin 6	Homo sapiens	60-64
10598880-3	1999	SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished.	Staurosporine	0-2	interleukin 6	Homo sapiens	67-71
10598880-3	1999	SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished.	Staurosporine	0-2	interleukin 6 cytokine family signal transducer	Homo sapiens	97-102
10598880-3	1999	SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished.	Staurosporine	0-2	signal transducer and activator of transcription 3	Homo sapiens	107-112
10598880-3	1999	SS was found effective in the blockade of the signaling cascade of IL-6: phosphorylation of both gp130 and Stat3 was eliminated by SS treatment and the production of IL-6 stimulated haptoglobin by the cells was abolished.	Staurosporine	0-2	interleukin 6	Homo sapiens	166-170
10598880-6	1999	The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types.	Staurosporine	15-17	interleukin 6	Homo sapiens	42-46
10598880-6	1999	The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types.	Staurosporine	15-17	interleukin 6	Homo sapiens	52-56
10598880-6	1999	The ability of SS to void the capacity of IL-6, and IL-6-related cytokines such as Oncostatin M, to deliver growth and differentiation signals may be one process by which this agent could promote apoptosis in a variety of cell types.	Staurosporine	15-17	oncostatin M	Homo sapiens	83-95
10619380-7	1999	The increased production of NO from rIFN-gamma plus SL-stimulated cells was decreased by the treatment with staurosporin.	Staurosporine	108-120	interferon gamma	Rattus norvegicus	36-46
10518116-8	1999	The expression of the proteins of the protooncogene Bcl-2 and the tumor suppressor gene p53 following staurosporine or retinoic acid treatment was assessed by Western blot and immunocytochemistry.	Staurosporine	102-115	BCL2 apoptosis regulator	Homo sapiens	52-57
10518116-8	1999	The expression of the proteins of the protooncogene Bcl-2 and the tumor suppressor gene p53 following staurosporine or retinoic acid treatment was assessed by Western blot and immunocytochemistry.	Staurosporine	102-115	tumor protein p53	Homo sapiens	88-91
10518116-9	1999	Retinoic acid increased Bcl-2 and decreased p53 levels, whereas staurosporine decreased Bcl-2 and increased p53 levels.	Staurosporine	64-77	BCL2 apoptosis regulator	Homo sapiens	88-93
10518116-9	1999	Retinoic acid increased Bcl-2 and decreased p53 levels, whereas staurosporine decreased Bcl-2 and increased p53 levels.	Staurosporine	64-77	tumor protein p53	Homo sapiens	108-111
10518116-10	1999	The opposite alteration of Bcl-2 (anti-apoptotic) and p53 (apoptotic) contents in SH-SY5Y cells with retinoic acid and staurosporine are attributed to the changes in cell vulnerability.	Staurosporine	119-132	BCL2 apoptosis regulator	Homo sapiens	27-32
10518116-10	1999	The opposite alteration of Bcl-2 (anti-apoptotic) and p53 (apoptotic) contents in SH-SY5Y cells with retinoic acid and staurosporine are attributed to the changes in cell vulnerability.	Staurosporine	119-132	tumor protein p53	Homo sapiens	54-57
10521466-3	1999	Our data show that PS1 and Bcl-2 assemble into a macromolecular complex, and that they are released from this complex in response to an apoptotic stimulus induced by staurosporine.	Staurosporine	166-179	presenilin 1	Homo sapiens	19-22
10521466-3	1999	Our data show that PS1 and Bcl-2 assemble into a macromolecular complex, and that they are released from this complex in response to an apoptotic stimulus induced by staurosporine.	Staurosporine	166-179	BCL2 apoptosis regulator	Homo sapiens	27-32
10659998-5	1999	Prior treatment of VSMCs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate BK-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Staurosporine	30-43	protein kinase C, alpha	Rattus norvegicus	58-61
10659998-5	1999	Prior treatment of VSMCs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate BK-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Staurosporine	30-43	protein kinase C, alpha	Rattus norvegicus	220-223
10527519-7	1999	IKK-1+2 and IKK-2 had similar K(m) values for ATP and GST-biotin-IkappaB(1-54) and were similarly inhibited by staurosporine and two of its analogues K252a and K252b, suggesting that most of the IkappaBalpha kinase activity in the IKK-1+2 complex may be attributed to IKK-2.	Staurosporine	111-124	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	0-5
10527519-7	1999	IKK-1+2 and IKK-2 had similar K(m) values for ATP and GST-biotin-IkappaB(1-54) and were similarly inhibited by staurosporine and two of its analogues K252a and K252b, suggesting that most of the IkappaBalpha kinase activity in the IKK-1+2 complex may be attributed to IKK-2.	Staurosporine	111-124	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	12-17
10523856-6	1999	TPA-mediated MDR1 induction was inhibited by several PKC inhibitors including staurosporine, H7 and calphostin C.	Staurosporine	78-91	ATP binding cassette subfamily B member 1	Homo sapiens	13-17
10523856-6	1999	TPA-mediated MDR1 induction was inhibited by several PKC inhibitors including staurosporine, H7 and calphostin C.	Staurosporine	78-91	protein kinase C alpha	Homo sapiens	53-56
10514472-6	1999	Upon staurosporine treatment, cytochrome c was released concomitantly with activation of caspase 3 and loss of mitochondrial membrane potential (Deltapsi(m)).	Staurosporine	5-18	caspase 3	Homo sapiens	89-98
10516278-9	1999	PTH inhibition of phosphate transport was maintained in phosphate-deprived cells and reversed by both GF109203X (10(-6) M) or staurosporine (5.5 nM), two protein kinase C inhibitors.	Staurosporine	126-139	parathyroid hormone	Homo sapiens	0-3
10502402-7	1999	The PKC inhibitors staurosporine and calphostin C, and the phosphatidylinositol 3-kinase (PI3-K) inhibitors wortmannin and LY294002, also prevented TRAIL mRNA transcription by activated T cells, indicating a role for PKC and PI3-K.	Staurosporine	19-32	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	148-153
10502411-8	1999	Treatment of nocodazole-arrested mitotic HeLa cells with staurosporine causes a dephosphorylation of pKi67 to the interphase state and a concomitant change in the localization of pKi67 with movement away from the perichromosomal layer to cytoplasmic dots that colocalize with nucleolin.	Staurosporine	57-70	nucleolin	Homo sapiens	276-285
14634335-6	1999	The induction of apoptosis by staurosporine or actinomycin D was markedly suppressed in caspase-9 beta-transfected HeLa cells.	Staurosporine	30-43	caspase 9	Homo sapiens	88-97
10497198-10	1999	Furthermore, caspase-7 activation was concommitant with PARP cleavage in the caspase-3-deficient cell line MCF-7 in response to staurosporine treatment.	Staurosporine	128-141	caspase 7	Homo sapiens	13-22
10491192-9	1999	Akt-3 activity could be inhibited by the broad spectrum kinase inhibitor staurosporine and by the PKC inhibitor Ro 31-8220, but not by other PKC or PKA inhibitors tested.	Staurosporine	73-86	AKT serine/threonine kinase 3	Homo sapiens	0-5
10526260-6	1999	NPY mRNA levels were also induced by protein kinase modulators (Bu)(2)cAMP and staurosporine in the cultures (P &lt; 0.05).	Staurosporine	79-92	neuropeptide Y	Homo sapiens	0-3
10497186-7	1999	ADP, thrombin, or U46619-induced Ca(2+)-independent platelet shape change was significantly reduced by staurosporine, a nonselective kinase inhibitor, by the selective p160 Rho-associated coiled-coil-containing protein kinase inhibitor Y-27632, or by HA 1077.	Staurosporine	103-116	coagulation factor II, thrombin	Homo sapiens	5-13
10509013-8	1999	These proteins not only overcome toxicity of Bax in yeast but also protect mammalian cells from apoptosis that is induced by staurosporine or Bax overexpression.	Staurosporine	125-138	BCL2 associated X, apoptosis regulator	Homo sapiens	45-48
10467260-6	1999	Both neo-transfected and the c-Akt dominant-negative transfected F-11 cells showed increased ceramide formation (twofold) in response to staurosporine, wortmannin, or LY294002; whereas cells with a constitutively active Akt (Myr-Akt) showed no increase in ceramide when treated with staurosporine, wortmannin, or LY294002.	Staurosporine	137-150	AKT serine/threonine kinase 1	Homo sapiens	31-34
10497214-9	1999	The differences in PITSLRE protein and cellular localization between A375 and UACC 1227 cells appear to account for the differences in sensitivity of the two cells lines to anti-Fas and staurosporine.	Staurosporine	186-199	cyclin dependent kinase 11A	Homo sapiens	19-26
10501196-6	1999	Preincubation with selective protein kinase C inhibitors, staurosporine or calphostin C, depressed the response of epsilon1/zeta1 and epsilon2/zeta1 receptors to insulin.	Staurosporine	58-71	insulin S homeolog	Xenopus laevis	162-169
10526133-3	1999	We looked at the expression of cyclin D1 in cortical neuronal cultures treated with either staurosporine to produce apoptotic death, or with glutamate, to produce a non-apoptotic death.	Staurosporine	91-104	cyclin D1	Homo sapiens	31-40
10526133-5	1999	Following the addition of either staurosporine or glutamate, cyclin D1 immunoreactivity did not change within 4 h. The cyclin D1 immunoreactivity was lost by 6 h with the appearance of either staurosporine-induced fragmented nuclei or glutamate-induced pyknotic nuclei.	Staurosporine	33-46	cyclin D1	Homo sapiens	61-70
10526133-5	1999	Following the addition of either staurosporine or glutamate, cyclin D1 immunoreactivity did not change within 4 h. The cyclin D1 immunoreactivity was lost by 6 h with the appearance of either staurosporine-induced fragmented nuclei or glutamate-induced pyknotic nuclei.	Staurosporine	33-46	cyclin D1	Homo sapiens	119-128
10486259-6	1999	Finally, we show that staurosporine-mediated caspase-3 activation is interrupted by maitotoxin pretreatment.	Staurosporine	22-35	caspase 3	Homo sapiens	45-54
10467260-6	1999	Both neo-transfected and the c-Akt dominant-negative transfected F-11 cells showed increased ceramide formation (twofold) in response to staurosporine, wortmannin, or LY294002; whereas cells with a constitutively active Akt (Myr-Akt) showed no increase in ceramide when treated with staurosporine, wortmannin, or LY294002.	Staurosporine	283-296	AKT serine/threonine kinase 1	Homo sapiens	31-34
10497198-10	1999	Furthermore, caspase-7 activation was concommitant with PARP cleavage in the caspase-3-deficient cell line MCF-7 in response to staurosporine treatment.	Staurosporine	128-141	poly(ADP-ribose) polymerase 1	Homo sapiens	56-60
10497198-10	1999	Furthermore, caspase-7 activation was concommitant with PARP cleavage in the caspase-3-deficient cell line MCF-7 in response to staurosporine treatment.	Staurosporine	128-141	caspase 3	Homo sapiens	77-86
10465260-7	1999	Similarly to H-89, the potent but unselective protein kinase inhibitor staurosporine inhibited the GLP-1-induced [Ca2+]cyt elevation only at high concentrations, at which it also inhibited glucose-induced [Ca2+]cyt elevations.	Staurosporine	71-84	glucagon	Mus musculus	99-104
10485875-7	1999	Pretreatment with the broad serine/threonine kinase inhibitor staurosporine partly blocked the calyculin A-induced STAT3 phosphorylation, whereas inhibitors of serine/threonine kinases, such as mitogen-activated protein kinase-1 extracellular-regulated kinase-kinase, mitogen-activated protein p38 kinase, and phosphatidylinositol 3-kinase, did not.	Staurosporine	62-75	signal transducer and activator of transcription 3	Homo sapiens	115-120
10477698-3	1999	The apoptotic pathway distal to the DISC is intact because ceramide analogs, staurosporine, and granzyme B activate caspase-3 and induce apoptosis.	Staurosporine	77-90	caspase 3	Homo sapiens	116-125
10511314-4	1999	c-myc expression was down-regulated in K562 differentiated by both TPA and staurosporine, whereas max expression did not change in either case.	Staurosporine	75-88	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
10495356-3	1999	Intensive screening has lead to the recent identification of a series of chemical inhibitors of CDKs: olomoucine, roscovitine, purvalanol, CVT-313, flavopiridol, g-butyrolactone, indirubins, paullones and staurosporine.	Staurosporine	205-218	cyclin dependent kinase 1	Homo sapiens	96-100
10477396-8	1999	TNF-alpha decreased VEGF production; the effect of TNF-alpha was neutralized by 10 nM staurosporine.	Staurosporine	86-99	tumor necrosis factor	Homo sapiens	0-9
10477396-8	1999	TNF-alpha decreased VEGF production; the effect of TNF-alpha was neutralized by 10 nM staurosporine.	Staurosporine	86-99	vascular endothelial growth factor A	Homo sapiens	20-24
10477396-8	1999	TNF-alpha decreased VEGF production; the effect of TNF-alpha was neutralized by 10 nM staurosporine.	Staurosporine	86-99	tumor necrosis factor	Homo sapiens	51-60
10461889-4	1999	ET-induced COX2 mRNA expression was suppressed by 5 microg/ml actinomycin D, 30 microM BAPTA/AM, inhibitors of protein kinase C (1-100 nM staurosporin and 100 microM H-7), 2 microM dexamethasone, and prolonged treatment with 100 nM phorbol 12-myristate 13-acetate.	Staurosporine	138-150	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	11-15
10510171-4	1999	The bcl-2 transgene was strongly expressed in these cells, and resulted in protection of neuronal cultures from death triggered by serum deprivation or exposure to staurosporine.	Staurosporine	164-177	BCL2, apoptosis regulator	Rattus norvegicus	4-9
10476784-15	1999	Staurosporine, PKC depletion, and TPA all enhanced ICAM-1 expression.	Staurosporine	0-13	intercellular adhesion molecule 1	Homo sapiens	51-57
10460245-5	1999	Agrin is active in cortical neurons at picomolar concentrations, is Ca(2+) dependent, and is inhibited by heparin and staurosporine.	Staurosporine	118-131	agrin	Homo sapiens	0-5
10468528-7	1999	In contrast, necrosis became the predominant form of cell death when PKC had been downregulated by prolonged exposure to 200 nmol/L phorbol 12,13-dibutyrate or inhibited by 50 nmol/L staurosporine, 100 nmol/L calphostin C, or 30 micromol/L H-7.	Staurosporine	183-196	protein kinase C, gamma	Rattus norvegicus	69-72
10449732-5	1999	The Bcl-x(L)-DTR fusion protein blocked apoptosis induced by staurosporine, gamma-irradiation, and poliovirus in a variety of cell types when added to media.	Staurosporine	61-74	BCL2 like 1	Homo sapiens	4-9
10468584-4	1999	We found that upon receptor-Janus kinase inactivation, either gradual or abruptly induced by staurosporine treatment, the flow of Stat1 was from cytoplasm to the nucleus and the nucleus was the final compartment in which phosphorylated Stat1 was detected.	Staurosporine	93-106	signal transducer and activator of transcription 1	Homo sapiens	130-135
10468584-4	1999	We found that upon receptor-Janus kinase inactivation, either gradual or abruptly induced by staurosporine treatment, the flow of Stat1 was from cytoplasm to the nucleus and the nucleus was the final compartment in which phosphorylated Stat1 was detected.	Staurosporine	93-106	signal transducer and activator of transcription 1	Homo sapiens	236-241
10438582-7	1999	Furthermore, examination of these cells in response to staurosporine revealed the release of mitochondrial cytochrome c into the cytosol over time, corresponding to caspase activation irrespective of mitochondrial depolarization.	Staurosporine	55-68	cytochrome c, somatic	Homo sapiens	107-119
10438583-2	1999	When treated with anti-Fas or staurosporine, only three of the four clones showed resistance to apoptosis that correlated with the level of Bcl-2 expression.	Staurosporine	30-43	BCL2 apoptosis regulator	Homo sapiens	140-145
10438583-5	1999	However, with staurosporine treatment the processing of all the caspases examined was inhibited to a similar degree by the different levels of Bcl-2 expression in the resistant clones.	Staurosporine	14-27	caspase 2	Homo sapiens	64-72
10438583-5	1999	However, with staurosporine treatment the processing of all the caspases examined was inhibited to a similar degree by the different levels of Bcl-2 expression in the resistant clones.	Staurosporine	14-27	BCL2 apoptosis regulator	Homo sapiens	143-148
10438583-6	1999	These results suggest that Bcl-2 blocked Fas-mediated cell death by acting downstream of caspase-8, which is in contrast to staurosporine-induced apoptosis where Bcl-2 is acting upstream of caspase-8.	Staurosporine	124-137	BCL2 apoptosis regulator	Homo sapiens	162-167
10438583-6	1999	These results suggest that Bcl-2 blocked Fas-mediated cell death by acting downstream of caspase-8, which is in contrast to staurosporine-induced apoptosis where Bcl-2 is acting upstream of caspase-8.	Staurosporine	124-137	caspase 8	Homo sapiens	190-199
10446305-5	1999	The inhibition of NaDC-1 transport by PMA was dose-dependent, and could be prevented by incubation of the oocytes with staurosporine.	Staurosporine	119-132	solute carrier family 13 member 2L homeolog	Xenopus laevis	18-24
10438458-7	1999	Expression of this mutant PARP increased the rate of staurosporine and tumor necrosis factor-alpha-induced apoptosis, at least in part by reducing the time interval required for the onset of caspase-3 activation and internucleosomal DNA fragmentation, as well as the generation of 50-kilobase pair DNA breaks, thought to be associated with early chromatin unfolding.	Staurosporine	53-66	poly(ADP-ribose) polymerase 1	Homo sapiens	26-30
10438458-7	1999	Expression of this mutant PARP increased the rate of staurosporine and tumor necrosis factor-alpha-induced apoptosis, at least in part by reducing the time interval required for the onset of caspase-3 activation and internucleosomal DNA fragmentation, as well as the generation of 50-kilobase pair DNA breaks, thought to be associated with early chromatin unfolding.	Staurosporine	53-66	caspase 3	Homo sapiens	191-200
10467260-9	1999	Both staurosporine and C(2)-ceramide activated the Jun kinase (JNK) cascade and C(2)-ceramide increased caspase-3 (CPP32) activity in cells expressing wild-type c-Jun, but not dominant-negative (TAM-67) c-Jun.	Staurosporine	5-18	mitogen-activated protein kinase 9	Homo sapiens	51-61
10467260-9	1999	Both staurosporine and C(2)-ceramide activated the Jun kinase (JNK) cascade and C(2)-ceramide increased caspase-3 (CPP32) activity in cells expressing wild-type c-Jun, but not dominant-negative (TAM-67) c-Jun.	Staurosporine	5-18	mitogen-activated protein kinase 9	Homo sapiens	63-66
10449732-7	1999	Brefeldin A, an inhibitor of vesicular traffic between the endoplasmic reticulum and Golgi apparatus, prevented the Bcl-x(L)-DTR blockade of apoptosis induced by staurosporine, suggesting that Bcl-x(L)-DTR must be endocytosed and reach intracellular compartments for activity.	Staurosporine	162-175	BCL2 like 1	Homo sapiens	116-121
10449732-7	1999	Brefeldin A, an inhibitor of vesicular traffic between the endoplasmic reticulum and Golgi apparatus, prevented the Bcl-x(L)-DTR blockade of apoptosis induced by staurosporine, suggesting that Bcl-x(L)-DTR must be endocytosed and reach intracellular compartments for activity.	Staurosporine	162-175	BCL2 like 1	Homo sapiens	193-198
10482916-10	1999	Co-injection of the PKC inhibitors, staurosporine (10 nmol) or RO 318220 (30 nmol) inhibited des-Arg9-BK-induced paw oedema (44 and 42% for IL-1beta and, 53 and 30% for TNFalpha, respectively).	Staurosporine	36-49	interleukin 1 beta	Rattus norvegicus	140-148
10482916-10	1999	Co-injection of the PKC inhibitors, staurosporine (10 nmol) or RO 318220 (30 nmol) inhibited des-Arg9-BK-induced paw oedema (44 and 42% for IL-1beta and, 53 and 30% for TNFalpha, respectively).	Staurosporine	36-49	tumor necrosis factor	Rattus norvegicus	169-177
10467354-5	1999	Measurements of caspase activity and cytochrome c release in cytosolic extracts of dex and staurosporine-treated cells indicated that the recessive Apt- mutations effect steps upstream of mitochondrial dysfunction.	Staurosporine	91-104	cytochrome c, somatic	Homo sapiens	37-49
10448011-3	1999	Treatment of PMN with genistein, staurosporine, and wortmannin, inhibitors of tyrosine kinases, protein kinase C, and phosphotidylinostol 3-kinase (PI 3-kinase) respectively, completely blocked the TNF-stimulated respiratory burst in PMN.	Staurosporine	33-46	tumor necrosis factor	Homo sapiens	198-201
10436021-2	1999	This specific modification is completely inhibited by the kinase inhibitor staurosporine and maximally promoted by the phosphatase inhibitor calyculin A, making it possible to purify the two forms of moesin to homogeneity.	Staurosporine	75-88	moesin	Homo sapiens	200-206
10582313-6	1999	The time course for docosahexaenoic acid induced enhancement of hsp70 mRNA was accelerated compared with heat shock alone, and staurosporine inhibited the docosahexaenoic acid induced increase of hsp70 mRNA.	Staurosporine	127-140	heat shock protein family A (Hsp70) member 8b	Oncorhynchus mykiss	196-201
10497883-8	1999	Bay K 8644-stimulated regucalcin mRNA expression in the hepatoma cells was completely blocked in the presence of trifluoperazine (10(-5) M), an antagonist of calmodulin, or staurosporine (10(-7) M), an inhibitor of protein kinase C. The stimulatory effect of PMA was clearly inhibited in the presence of stauroporine.	Staurosporine	173-186	regucalcin	Rattus norvegicus	22-32
10438594-3	1999	We found that in the absence of PARP, while expression of DBD has only a marginal effect, expression of the mutants strongly inhibits the apoptosis induced by staurosporine, as measured by the binding of annexin V.	Staurosporine	159-172	annexin A5	Homo sapiens	204-213
10409669-10	1999	However, transient transfection of caspase-3 into MCF-7 cells restores Bcl-2 cleavage after staurosporine treatment.	Staurosporine	92-105	caspase 3	Homo sapiens	35-44
10452527-5	1999	Concentrations of staurosporine, that inhibits PKC-zeta, prevent DA-dependent inhibition of Na+,K+-ATPase and a similar effect was obtained with a PKC-zeta inhibitor peptide.	Staurosporine	18-31	protein kinase C zeta	Homo sapiens	47-55
10452527-5	1999	Concentrations of staurosporine, that inhibits PKC-zeta, prevent DA-dependent inhibition of Na+,K+-ATPase and a similar effect was obtained with a PKC-zeta inhibitor peptide.	Staurosporine	18-31	protein kinase C zeta	Homo sapiens	147-155
10409703-7	1999	Finally, we show that staurosporine, a kinase inhibitor, induces an increased electrophoretic mobility of p120(ctn) bound to E-cadherin polypeptides, activates the nonfunctional E-cadherin protein, and converts the wild-type E-cadherin and an E-cadherin-alpha-catenin chimeric protein from a cytochalasin D-sensitive to a cytochalasin D-insensitive state.	Staurosporine	22-35	catenin delta 1	Homo sapiens	106-110
10409669-10	1999	However, transient transfection of caspase-3 into MCF-7 cells restores Bcl-2 cleavage after staurosporine treatment.	Staurosporine	92-105	BCL2 apoptosis regulator	Homo sapiens	71-76
10409703-7	1999	Finally, we show that staurosporine, a kinase inhibitor, induces an increased electrophoretic mobility of p120(ctn) bound to E-cadherin polypeptides, activates the nonfunctional E-cadherin protein, and converts the wild-type E-cadherin and an E-cadherin-alpha-catenin chimeric protein from a cytochalasin D-sensitive to a cytochalasin D-insensitive state.	Staurosporine	22-35	cadherin 1	Homo sapiens	125-135
10400666-6	1999	Particularly instructive was that the V15E mutant of Bcl-2, which completely lost the ability to form a heterodimer with Bax, failed to inhibit Bax- and staurosporine-induced apoptosis.	Staurosporine	153-166	B cell leukemia/lymphoma 2	Mus musculus	53-58
10409703-7	1999	Finally, we show that staurosporine, a kinase inhibitor, induces an increased electrophoretic mobility of p120(ctn) bound to E-cadherin polypeptides, activates the nonfunctional E-cadherin protein, and converts the wild-type E-cadherin and an E-cadherin-alpha-catenin chimeric protein from a cytochalasin D-sensitive to a cytochalasin D-insensitive state.	Staurosporine	22-35	cadherin 1	Homo sapiens	178-188
10409703-7	1999	Finally, we show that staurosporine, a kinase inhibitor, induces an increased electrophoretic mobility of p120(ctn) bound to E-cadherin polypeptides, activates the nonfunctional E-cadherin protein, and converts the wild-type E-cadherin and an E-cadherin-alpha-catenin chimeric protein from a cytochalasin D-sensitive to a cytochalasin D-insensitive state.	Staurosporine	22-35	cadherin 1	Homo sapiens	178-188
10409703-7	1999	Finally, we show that staurosporine, a kinase inhibitor, induces an increased electrophoretic mobility of p120(ctn) bound to E-cadherin polypeptides, activates the nonfunctional E-cadherin protein, and converts the wild-type E-cadherin and an E-cadherin-alpha-catenin chimeric protein from a cytochalasin D-sensitive to a cytochalasin D-insensitive state.	Staurosporine	22-35	cadherin 1	Homo sapiens	178-188
10448929-8	1999	Both calmidazolium and staurosporine, but not KN-62, prevented the stimulatory action of carbachol on the H+-K+-ATPase, suggesting a synergistic control of this ion pump by both Ca2+-calmodulin and protein kinase C.	Staurosporine	23-36	calmodulin 1	Rattus norvegicus	183-193
10400706-7	1999	Staurosporine and ML-9, which inhibited the phosphorylation of PTP36 in vivo, induced the translocation of PTP36 too.	Staurosporine	0-13	protein tyrosine phosphatase, non-receptor type 14	Mus musculus	63-68
10400706-7	1999	Staurosporine and ML-9, which inhibited the phosphorylation of PTP36 in vivo, induced the translocation of PTP36 too.	Staurosporine	0-13	protein tyrosine phosphatase, non-receptor type 14	Mus musculus	107-112
10406804-9	1999	Moreover, WT1 expressing cells displaying upregulated Bcl-2 were found to be resistant to apoptosis induced by staurosporine, vincristine and doxorubicine.	Staurosporine	111-124	WT1 transcription factor	Homo sapiens	10-13
10406804-9	1999	Moreover, WT1 expressing cells displaying upregulated Bcl-2 were found to be resistant to apoptosis induced by staurosporine, vincristine and doxorubicine.	Staurosporine	111-124	BCL2 apoptosis regulator	Homo sapiens	54-59
10455280-0	1999	Participation of protein kinases in staurosporine-induced interleukin-6 production by rat peritoneal macrophages.	Staurosporine	36-49	interleukin 6	Rattus norvegicus	58-71
10501019-3	1999	Conversely, the PKC inhibitors, staurosporine (STAURO) and polymyxin B (PMB), each increased [3H]choline cotransport.	Staurosporine	32-45	proline rich transmembrane protein 2	Homo sapiens	16-19
10501019-3	1999	Conversely, the PKC inhibitors, staurosporine (STAURO) and polymyxin B (PMB), each increased [3H]choline cotransport.	Staurosporine	47-53	proline rich transmembrane protein 2	Homo sapiens	16-19
10381916-6	1999	NF-kappaB activation induced by PMA was blocked by the protein kinase C inhibitor staurosporine but not by the proteasomal inhibitor N-acetyl-leucine leucine norleucinal (ALLN).	Staurosporine	82-95	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10381916-7	1999	In contrast, IL-1beta-induced NF-kappaB activation was associated with the disappearance of IkappaBalpha and was inhibited by ALLN but not staurosporine.	Staurosporine	139-152	interleukin 1 beta	Homo sapiens	13-21
10381916-7	1999	In contrast, IL-1beta-induced NF-kappaB activation was associated with the disappearance of IkappaBalpha and was inhibited by ALLN but not staurosporine.	Staurosporine	139-152	nuclear factor kappa B subunit 1	Homo sapiens	30-39
10791920-3	1999	However, with serum-stimulation, the amounts of IPt and PEt at 32 degrees C were less than those at 39 degrees C. Pretreatment with PKC inhibitors, Ro-31-8220 and staurosporine, enhanced the accumulation of IPt but not of PEt at 32 degrees C. The tyrosine phosphorylation of phospholipase Cgamma1 (PLCgamma1) was increased either by serum or by pp60(v-src) reactivation.	Staurosporine	163-176	phospholipase C gamma 1	Homo sapiens	298-307
10381264-5	1999	This increase was clearly inhibited by the presence of EGTA (10(-3) M), A23187 (10(-6) M), trifluoperazine (10(-5) M), staurosporine (10(-7) M), or genistein (10(-5) M) with 6-h-culture, although the beta-actin mRNA expression was not altered by the reagents.	Staurosporine	119-132	actin, beta	Rattus norvegicus	200-210
10385700-0	1999	The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor.	Staurosporine	4-17	neurotrophin 3	Homo sapiens	91-105
10385700-0	1999	The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor.	Staurosporine	4-17	neurotrophic receptor tyrosine kinase 1	Homo sapiens	135-139
10385700-1	1999	K-252b, a member of the staurosporine family of protein kinase inhibitors, selectively potentiates the activation of the nerve growth factor receptor, TrkA, by a nonpreferred ligand, neurotrophin-3 (NT-3), in a variety of cell types.	Staurosporine	24-37	nerve growth factor receptor	Homo sapiens	121-149
10385700-1	1999	K-252b, a member of the staurosporine family of protein kinase inhibitors, selectively potentiates the activation of the nerve growth factor receptor, TrkA, by a nonpreferred ligand, neurotrophin-3 (NT-3), in a variety of cell types.	Staurosporine	24-37	neurotrophic receptor tyrosine kinase 1	Homo sapiens	151-155
10385700-1	1999	K-252b, a member of the staurosporine family of protein kinase inhibitors, selectively potentiates the activation of the nerve growth factor receptor, TrkA, by a nonpreferred ligand, neurotrophin-3 (NT-3), in a variety of cell types.	Staurosporine	24-37	neurotrophin 3	Homo sapiens	183-197
10559901-2	1999	Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1.	Staurosporine	93-106	heme oxygenase 1	Mus musculus	46-49
10559901-2	1999	Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1.	Staurosporine	93-106	heme oxygenase 1	Mus musculus	195-198
10559901-2	1999	Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1.	Staurosporine	93-106	heme oxygenase 1	Mus musculus	195-198
10456578-3	1999	This increase was eliminated with pretreatment of PC12 cells with staurosporine, suggesting that the effects of ethanol on nNOS expression are mediated by a protein kinase C-dependent pathway.	Staurosporine	66-79	nitric oxide synthase 1	Rattus norvegicus	123-127
10455280-1	1999	The incubation of rat peritoneal macrophages in the presence of staurosporine, a non-specific protein kinase inhibitor, induced interleukin-6 (IL-6) production in a time- and concentration-dependent manner at 6.3-63 nM, but at 210 nM, the stimulant effect on IL-6 production was reduced.	Staurosporine	64-77	interleukin 6	Rattus norvegicus	128-141
10455280-1	1999	The incubation of rat peritoneal macrophages in the presence of staurosporine, a non-specific protein kinase inhibitor, induced interleukin-6 (IL-6) production in a time- and concentration-dependent manner at 6.3-63 nM, but at 210 nM, the stimulant effect on IL-6 production was reduced.	Staurosporine	64-77	interleukin 6	Rattus norvegicus	143-147
10455280-1	1999	The incubation of rat peritoneal macrophages in the presence of staurosporine, a non-specific protein kinase inhibitor, induced interleukin-6 (IL-6) production in a time- and concentration-dependent manner at 6.3-63 nM, but at 210 nM, the stimulant effect on IL-6 production was reduced.	Staurosporine	64-77	interleukin 6	Rattus norvegicus	259-263
10455280-2	1999	The levels of IL-6 mRNA as determined by a reverse transcription-polymerase chain reaction were also increased by staurosporine in parallel with the ability to induce IL-6 production.	Staurosporine	114-127	interleukin 6	Rattus norvegicus	14-18
10455280-2	1999	The levels of IL-6 mRNA as determined by a reverse transcription-polymerase chain reaction were also increased by staurosporine in parallel with the ability to induce IL-6 production.	Staurosporine	114-127	interleukin 6	Rattus norvegicus	167-171
10455280-5	1999	The staurosporine-induced increase in IL-6 production was not affected by the PKA inhibitor, H-89 (0.1-3 microM).	Staurosporine	4-17	interleukin 6	Rattus norvegicus	38-42
10380075-3	1999	The anti-apoptosis effect of insulin against serum deprivation disappeared by addition of a broad protein kinase inhibitor, staurosporine, but not by calphostin C, a selective protein kinase C inhibitor.	Staurosporine	124-137	insulin	Homo sapiens	29-36
10455280-6	1999	These findings suggest that the induction of IL-6 production by staurosporine is secondary to elevation of IL-6 mRNA level, which, in turn, is positively regulated by the activation of PKC and PI 3-kinase and negatively regulated by the activation of PTK.	Staurosporine	64-77	interleukin 6	Rattus norvegicus	45-49
10455280-6	1999	These findings suggest that the induction of IL-6 production by staurosporine is secondary to elevation of IL-6 mRNA level, which, in turn, is positively regulated by the activation of PKC and PI 3-kinase and negatively regulated by the activation of PTK.	Staurosporine	64-77	interleukin 6	Rattus norvegicus	107-111
10404594-5	1999	RESULTS: We report here the high-resolution crystal structures of an activated Lck kinase domain in complex with three structurally distinct ATP-competitive inhibitors: AMP-PNP (a non-selective, non-hydrolyzable ATP analog); staurosporine (a potent but non-selective protein kinase inhibitor); and PP2 (a potent Src family selective protein tyrosine kinase inhibitor).	Staurosporine	225-238	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	79-82
10404594-8	1999	CONCLUSIONS: The potency of staurosporine against Lck derives in part from an induced movement of the glycine-rich loop of the enzyme upon binding of this ligand, which maximizes the van der Waals interactions present in the complex.	Staurosporine	28-41	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
10354507-2	1999	The staurosporine-induced MIP-2 production at 4 h was inhibited by the highly specific p38 MAPK inhibitor SB 203580 and the MAPK/ERK kinase (MEK-1) inhibitor PD 98059 in a concentration-dependent manner.	Staurosporine	4-17	mitogen activated protein kinase kinase 1	Rattus norvegicus	141-146
10354507-0	1999	Involvement of p38 MAPK and ERK/MAPK pathways in staurosporine-induced production of macrophage inflammatory protein-2 in rat peritoneal neutrophils.	Staurosporine	49-62	Eph receptor B1	Rattus norvegicus	28-31
10354507-3	1999	By treatment with SB 203580 (1 microM) or PD 98059 (50 microM), the staurosporine-induced increase in the levels of mRNA for MIP-2 was only partially lowered, although the staurosporine-induced MIP-2 production was completely inhibited.	Staurosporine	68-81	C-X-C motif chemokine ligand 2	Rattus norvegicus	125-130
10354507-0	1999	Involvement of p38 MAPK and ERK/MAPK pathways in staurosporine-induced production of macrophage inflammatory protein-2 in rat peritoneal neutrophils.	Staurosporine	49-62	C-X-C motif chemokine ligand 2	Rattus norvegicus	85-118
10354507-1	1999	Stimulation of rat peritoneal neutrophils with staurosporine (64 nM) induced production of macrophage inflammatory protein-2 (MIP-2) and phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase/MAP kinase (ERK/MAPK).	Staurosporine	47-60	C-X-C motif chemokine ligand 2	Rattus norvegicus	91-124
10354507-1	1999	Stimulation of rat peritoneal neutrophils with staurosporine (64 nM) induced production of macrophage inflammatory protein-2 (MIP-2) and phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase/MAP kinase (ERK/MAPK).	Staurosporine	47-60	C-X-C motif chemokine ligand 2	Rattus norvegicus	126-131
10354507-1	1999	Stimulation of rat peritoneal neutrophils with staurosporine (64 nM) induced production of macrophage inflammatory protein-2 (MIP-2) and phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase/MAP kinase (ERK/MAPK).	Staurosporine	47-60	mitogen activated protein kinase 14	Rattus norvegicus	156-192
10354507-1	1999	Stimulation of rat peritoneal neutrophils with staurosporine (64 nM) induced production of macrophage inflammatory protein-2 (MIP-2) and phosphorylation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase/MAP kinase (ERK/MAPK).	Staurosporine	47-60	Eph receptor B1	Rattus norvegicus	254-257
10354507-2	1999	The staurosporine-induced MIP-2 production at 4 h was inhibited by the highly specific p38 MAPK inhibitor SB 203580 and the MAPK/ERK kinase (MEK-1) inhibitor PD 98059 in a concentration-dependent manner.	Staurosporine	4-17	C-X-C motif chemokine ligand 2	Rattus norvegicus	26-31
10354507-2	1999	The staurosporine-induced MIP-2 production at 4 h was inhibited by the highly specific p38 MAPK inhibitor SB 203580 and the MAPK/ERK kinase (MEK-1) inhibitor PD 98059 in a concentration-dependent manner.	Staurosporine	4-17	Eph receptor B1	Rattus norvegicus	129-132
10354507-3	1999	By treatment with SB 203580 (1 microM) or PD 98059 (50 microM), the staurosporine-induced increase in the levels of mRNA for MIP-2 was only partially lowered, although the staurosporine-induced MIP-2 production was completely inhibited.	Staurosporine	68-81	C-X-C motif chemokine ligand 2	Rattus norvegicus	194-199
10354507-3	1999	By treatment with SB 203580 (1 microM) or PD 98059 (50 microM), the staurosporine-induced increase in the levels of mRNA for MIP-2 was only partially lowered, although the staurosporine-induced MIP-2 production was completely inhibited.	Staurosporine	172-185	C-X-C motif chemokine ligand 2	Rattus norvegicus	194-199
10381005-0	1999	Staurosporine enhances cAMP-induced expression of neural-specific gene VGF and tyrosine hydroxylase.	Staurosporine	0-13	VGF nerve growth factor inducible	Homo sapiens	71-74
10359585-4	1999	In addition, the mutation of the potential ubiquitin-acceptor amino acids of Bcl-2 provides protection against TNF-alpha- and staurosporine-induced degradation in vitro and in vivo.	Staurosporine	126-139	BCL2 apoptosis regulator	Homo sapiens	77-82
10381005-2	1999	The simultaneous presence of staurosporine (SSP) caused a progressive, rather than transient, increase in VGF mRNA levels during the cAMP-induced differentiation of human neuroblastoma cells.	Staurosporine	29-42	VGF nerve growth factor inducible	Homo sapiens	106-109
10381005-2	1999	The simultaneous presence of staurosporine (SSP) caused a progressive, rather than transient, increase in VGF mRNA levels during the cAMP-induced differentiation of human neuroblastoma cells.	Staurosporine	44-47	VGF nerve growth factor inducible	Homo sapiens	106-109
10375546-9	1999	In Cos-7 cells, caspase-1 and caspase-3 substrates were cleaved upon induction of apoptosis with staurosporine, a protein-kinase inhibitor, whereas caspase-3 but not caspase-1 substrate was cleaved upon treatment of cells with the DNA-damaging agent mitomycin c.	Staurosporine	97-110	caspase 1	Homo sapiens	16-25
10400313-0	1999	Resistance of initiation factor 2 (eIF-2alpha) kinases to staurosporine: an approach for assaying the kinases in crude extracts.	Staurosporine	58-71	eukaryotic translation initiation factor 2A	Homo sapiens	35-45
10400313-1	1999	We studied the effect of staurosporine on two well characterised mammalian eIF-2alpha kinases, the heme-regulated translational inhibitor (HRI), and interferon-inducible double-stranded RNA-activated protein kinase (PKR).	Staurosporine	25-38	eukaryotic translation initiation factor 2A	Homo sapiens	75-85
10400313-3	1999	In the presence of 0.25 microM staurosporine (a concentration which completely inhibits a wide range of Ser/Thr protein kinases), the phosphorylation of eIF-2alpha by HRI and PKR was not inhibited.	Staurosporine	31-44	eukaryotic translation initiation factor 2A	Homo sapiens	153-163
10400313-3	1999	In the presence of 0.25 microM staurosporine (a concentration which completely inhibits a wide range of Ser/Thr protein kinases), the phosphorylation of eIF-2alpha by HRI and PKR was not inhibited.	Staurosporine	31-44	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	167-170
10400313-3	1999	In the presence of 0.25 microM staurosporine (a concentration which completely inhibits a wide range of Ser/Thr protein kinases), the phosphorylation of eIF-2alpha by HRI and PKR was not inhibited.	Staurosporine	31-44	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	175-178
10400313-4	1999	The lack of response of eIF-2alpha kinases to staurosporine allowed us to measure PKR activity in salt washed postmicrosomal supernatants without previous purification of the enzyme.	Staurosporine	46-59	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	82-85
10400313-8	1999	Although its phosphorylation is specific because it displaces eIF-2 phosphorylation, and the presence of staurosporine prevents its phosphorylation by other serine/threonine kinases, it is a rather poor substrate for PKR.	Staurosporine	105-118	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	217-220
10375546-9	1999	In Cos-7 cells, caspase-1 and caspase-3 substrates were cleaved upon induction of apoptosis with staurosporine, a protein-kinase inhibitor, whereas caspase-3 but not caspase-1 substrate was cleaved upon treatment of cells with the DNA-damaging agent mitomycin c.	Staurosporine	97-110	caspase 3	Homo sapiens	30-39
10230500-0	1999	Staurosporine enhances parathyroid hormone-induced calcium signal in UMR-106 osteoblastic cells.	Staurosporine	0-13	parathyroid hormone	Rattus norvegicus	23-42
10366415-8	1999	In cultured pheochromocytoma cells, treatment with (Bu)2cAMP and a protein kinase inhibitor, staurosporine, increased pG2 mRNA accumulation (2- to 4-fold over the control level, P&lt;0.01, and 3- to 8-fold, P&lt;0.01, respectively).	Staurosporine	93-106	delta like non-canonical Notch ligand 1	Homo sapiens	118-121
10455420-3	1999	In this study we genetically engineered betaTC-tet cells with the anti-apoptotic gene Bcl-2 using new lentiviral vectors and showed that it protected this cell line against apoptosis induced by hypoxia, staurosporine and a mixture of cytokines (IL-1beta, IFN-gamma and TNF-alpha).	Staurosporine	203-216	B cell leukemia/lymphoma 2	Mus musculus	86-91
10339669-4	1999	The invasiveness and the production of MMP-9 were decreased with staurosporine but not indomethacine.	Staurosporine	65-78	matrix metallopeptidase 9	Homo sapiens	39-44
10347243-5	1999	Incubation of oocytes in the phospholipase C inhibitor U73122 or the protein kinase C (PKC) inhibitors chelerythrine and staurosporine significantly reduced the inhibition of GIRK currents by neuromedin B, whereas the Ca2+ chelator, BAPTA-AM had no effect.	Staurosporine	121-134	potassium inwardly rectifying channel subfamily J member 3 S homeolog	Xenopus laevis	175-179
10347243-5	1999	Incubation of oocytes in the phospholipase C inhibitor U73122 or the protein kinase C (PKC) inhibitors chelerythrine and staurosporine significantly reduced the inhibition of GIRK currents by neuromedin B, whereas the Ca2+ chelator, BAPTA-AM had no effect.	Staurosporine	121-134	neuromedin B S homeolog	Xenopus laevis	192-204
10339431-9	1999	The chromosomal DNA in cells expressing caspase-resistant ICAD remained intact after treatment with staurosporine but their chromatin condensed as found in parental Jurkat cells.	Staurosporine	100-113	DNA fragmentation factor subunit alpha	Homo sapiens	58-62
10222045-7	1999	Staurosporine reversed the AII-evoked attenuation of isoproterenol- and NECA-stimulated enzyme activity.	Staurosporine	0-13	angiotensinogen	Homo sapiens	27-30
10408834-7	1999	Both the FMLP- and the TNF-alpha-dependent systems were also found to be equally susceptible to inhibition by various inhibitors of kinases (genistein, staurosporin, 1-(5-isoquinolinnylsulphonyl)-2-methylpiperazine and wortmannin).	Staurosporine	152-164	formyl peptide receptor 1	Homo sapiens	9-13
10408834-7	1999	Both the FMLP- and the TNF-alpha-dependent systems were also found to be equally susceptible to inhibition by various inhibitors of kinases (genistein, staurosporin, 1-(5-isoquinolinnylsulphonyl)-2-methylpiperazine and wortmannin).	Staurosporine	152-164	tumor necrosis factor	Homo sapiens	23-32
10199557-0	1999	Cytoplasmic elongation and rupture in megakaryoblastic leukemia cells via activation of adhesion and motility by staurosporine on fibronectin-bound substratum.	Staurosporine	113-126	fibronectin 1	Homo sapiens	130-141
10199557-1	1999	Human megakaryoblastic leukemia Meg-01 cells were attached to fibronectin (FN)-coated substratum, on which remarkable spreading and cytoplasmic elongation was induced by treatment with a protein kinase inhibitor, staurosporine (stp).	Staurosporine	213-226	fibronectin 1	Homo sapiens	62-73
10199557-1	1999	Human megakaryoblastic leukemia Meg-01 cells were attached to fibronectin (FN)-coated substratum, on which remarkable spreading and cytoplasmic elongation was induced by treatment with a protein kinase inhibitor, staurosporine (stp).	Staurosporine	213-226	fibronectin 1	Homo sapiens	75-77
10199557-1	1999	Human megakaryoblastic leukemia Meg-01 cells were attached to fibronectin (FN)-coated substratum, on which remarkable spreading and cytoplasmic elongation was induced by treatment with a protein kinase inhibitor, staurosporine (stp).	Staurosporine	228-231	fibronectin 1	Homo sapiens	75-77
10199557-8	1999	Actin microfilaments in the stp-treated Meg-01 cells accumulated in the filopodia and periphery of the extended cytoplasm, in which vinculin was colocalized as adhesion plaques.	Staurosporine	28-31	vinculin	Homo sapiens	132-140
10492007-7	1999	Protein kinase involvement was confirmed with the broad spectrum inhibitor staurosporine, which prevented the response to BDNF.	Staurosporine	75-88	brain derived neurotrophic factor	Homo sapiens	122-126
10198224-7	1999	Staurosporin, a protein kinase C (PKC) inhibitor, inhibited the induction of ICAM-1 on NA cells by NO, whereas genistein, a protein tyrosine kinase inhibitor, did not.	Staurosporine	0-12	intercellular adhesion molecule 1	Homo sapiens	77-83
10092607-8	1999	However, treatment of myotubes with staurosporine or 12-O-tetradecanoylphorbol-13-acetate reduced the effect of A23187 on cytochrome c transactivation by 40-50%.	Staurosporine	36-49	cytochrome c, somatic	Homo sapiens	122-134
10733343-2	1999	The effect is sensitive to inhibition by staurosporine, KT 5926 (an inhibitor of myosin light chain kinase), and cytochalasin B, suggesting that LPA activates the phosphorylation of myosin light chain and increases the contractile activity of the actomyosin network.	Staurosporine	41-54	myosin light chain kinase	Homo sapiens	81-106
10401993-8	1999	The increased production of NO from rIFN-gamma plus TO-stimulated cells was decreased by treatment with a protein kinase C inhibitor such as staurosporin.	Staurosporine	141-153	interferon gamma	Rattus norvegicus	36-46
10349855-0	1999	Sequential cleavage of poly(ADP-ribose)polymerase and appearance of a small Bax-immunoreactive protein are blocked by Bcl-X(L) and caspase inhibitors during staurosporine-induced dopaminergic neuronal apoptosis.	Staurosporine	157-170	poly (ADP-ribose) polymerase family, member 1	Mus musculus	23-49
10349855-0	1999	Sequential cleavage of poly(ADP-ribose)polymerase and appearance of a small Bax-immunoreactive protein are blocked by Bcl-X(L) and caspase inhibitors during staurosporine-induced dopaminergic neuronal apoptosis.	Staurosporine	157-170	BCL2-associated X protein	Mus musculus	76-79
10349855-0	1999	Sequential cleavage of poly(ADP-ribose)polymerase and appearance of a small Bax-immunoreactive protein are blocked by Bcl-X(L) and caspase inhibitors during staurosporine-induced dopaminergic neuronal apoptosis.	Staurosporine	157-170	BCL2-like 1	Mus musculus	118-126
10349855-1	1999	To assess the role of Bcl-X(L) and its splice derivative, Bcl-X(S), in staurosporine-induced cell death, we used a dopaminergic cell line, MN9D, transfected with bcl-xL (MN9D/Bcl-X(L)), bcl-xS (MN9D/Bcl-X(S)), or control vector (MN9D/Neo).	Staurosporine	71-84	BCL2-like 1	Mus musculus	58-63
10349855-5	1999	Bcl-X(L) prevented morphologically apoptotic changes as well as cleavage of poly(ADP-ribose)polymerase (PARP) induced by staurosporine.	Staurosporine	121-134	BCL2-like 1	Mus musculus	0-8
10349855-5	1999	Bcl-X(L) prevented morphologically apoptotic changes as well as cleavage of poly(ADP-ribose)polymerase (PARP) induced by staurosporine.	Staurosporine	121-134	poly (ADP-ribose) polymerase family, member 1	Mus musculus	76-102
10349855-5	1999	Bcl-X(L) prevented morphologically apoptotic changes as well as cleavage of poly(ADP-ribose)polymerase (PARP) induced by staurosporine.	Staurosporine	121-134	poly (ADP-ribose) polymerase family, member 1	Mus musculus	104-108
10349855-9	1999	Thus, our present study suggests that Bcl-X(L) but not Bcl-X(S) prevents staurosporine-induced apoptosis by inhibiting the caspase activation that may be directly or indirectly responsible for the appearance of the small Bax-immunoreactive protein in some types of neurons.	Staurosporine	73-86	BCL2-like 1	Mus musculus	38-46
10349855-9	1999	Thus, our present study suggests that Bcl-X(L) but not Bcl-X(S) prevents staurosporine-induced apoptosis by inhibiting the caspase activation that may be directly or indirectly responsible for the appearance of the small Bax-immunoreactive protein in some types of neurons.	Staurosporine	73-86	BCL2-like 1	Mus musculus	38-43
10320744-3	1999	Our data demonstrate that at 22 h after MCAo, staurosporine triggered a significant increase in apoptosis, a reduction of lesion volume and an increase of synaptophysin immunoreactivity, as compared to the control group.	Staurosporine	46-59	synaptophysin	Rattus norvegicus	155-168
10319282-7	1999	The increased production of NO from rIFN-gamma plus UrCE-stimulated cells was decreased by the treatment of protein kinase C inhibitor such as staurosporin.	Staurosporine	143-155	interferon gamma	Rattus norvegicus	36-46
10217266-2	1999	We used western blot analysis to demonstrate that the proapoptotic protein Bax translocated from the cytosolic to the mitochondrial fraction in SH-SY5Y human neuroblastoma cells undergoing staurosporine- or EGTA-mediated apoptosis.	Staurosporine	189-202	BCL2 associated X, apoptosis regulator	Homo sapiens	75-78
10217266-3	1999	Levels of mitochondrial Bax increased 15 min after staurosporine treatment.	Staurosporine	51-64	BCL2 associated X, apoptosis regulator	Homo sapiens	24-27
10217266-4	1999	In EGTA-treated cells, increased levels of mitochondrial Bax were seen at 4 h, consistent with a slower onset of apoptosis in EGTA versus staurosporine treatments.	Staurosporine	138-151	BCL2 associated X, apoptosis regulator	Homo sapiens	57-60
10212240-10	1999	Furthermore, staurosporine did not inhibit internalization although it blocked phorbol 12-myristate 13-acetate-induced CCR-3 down-modulation.	Staurosporine	13-26	C-C motif chemokine receptor 3	Homo sapiens	119-124
10196212-3	1999	Inhibition of the constitutive levels of Bcl-XL caused 10-25% of the cell population to undergo apoptosis and increased the susceptibility of cells to treatment with low concentrations of staurosporin or ceramide.	Staurosporine	188-200	BCL2 like 1	Homo sapiens	41-47
10205158-5	1999	Induction of apoptosis with staurosporine led to the activation of mitochondrial pro-caspase-3 and its dissociation from the Hsps which were released from mitochondria.	Staurosporine	28-41	caspase 3	Homo sapiens	81-94
10230500-2	1999	We have found that acute phorbol ester pretreatment significantly decreases PTH-induced calcium transients and the effect of phorbol ester was antagonized by staurosporine (ST).	Staurosporine	158-171	parathyroid hormone	Rattus norvegicus	76-79
10230500-2	1999	We have found that acute phorbol ester pretreatment significantly decreases PTH-induced calcium transients and the effect of phorbol ester was antagonized by staurosporine (ST).	Staurosporine	173-175	parathyroid hormone	Rattus norvegicus	76-79
10230502-4	1999	Interestingly, a protein kinase C (PKC) inhibitor staurosporine (50 nM) abolished the induction of mGBP3 expression by LPS, but not by IFN-gamma.	Staurosporine	50-63	guanylate binding protein 3	Mus musculus	99-104
10230502-4	1999	Interestingly, a protein kinase C (PKC) inhibitor staurosporine (50 nM) abolished the induction of mGBP3 expression by LPS, but not by IFN-gamma.	Staurosporine	50-63	toll-like receptor 4	Mus musculus	119-122
10098499-7	1999	The increase in Bcl-2 expression, mediated by VD3, correlated with protection of thyrocytes against the induction of apoptosis by either staurosporine or UV irradiation.	Staurosporine	137-150	BCL2 apoptosis regulator	Homo sapiens	16-21
10092616-12	1999	The effect of TNF-alpha and SMase was inhibited by the kinase inhibitor staurosporin and by the protein kinase C (PKC) inhibitor calphostin C but not by down-regulation of PKC.	Staurosporine	72-84	tumor necrosis factor	Rattus norvegicus	14-23
10191118-5	1999	CLN3 overexpression in NT2 cells enhances growth, reverses growth inhibition induced by serum starvation and protects from apoptosis induced by vincristine, staurosporine, and etoposide but not from death caused by ceramide.	Staurosporine	157-170	CLN3 lysosomal/endosomal transmembrane protein, battenin	Homo sapiens	0-4
10066378-4	1999	We demonstrate that cytochrome c is released from mitochondria of Jurkat cells in response to both staurosporine and an agonistic anti-Fas antibody and that only the latter is inhibited by the caspase inhibitor z-VAD-FMK.	Staurosporine	99-112	cytochrome c, somatic	Homo sapiens	20-32
10066378-4	1999	We demonstrate that cytochrome c is released from mitochondria of Jurkat cells in response to both staurosporine and an agonistic anti-Fas antibody and that only the latter is inhibited by the caspase inhibitor z-VAD-FMK.	Staurosporine	99-112	caspase 8	Homo sapiens	193-200
10092822-5	1999	L-selectin attachment to the cytoskeleton was not prevented by inhibitors of actin/microtubule polymerization (cytochalasin B, colchicine, or nocodozole) or serine/threonine and tyrosine kinase activity (staurosporine, calphostin C, or genistein), although L-selectin-mediated adhesion of human PBL was markedly suppressed by these agents.	Staurosporine	204-217	selectin L	Homo sapiens	0-10
10037816-5	1999	Moreover, the message level of ES18 was selectively enhanced by staurosporine, a broad protein kinase inhibitor, but not by other protein kinase inhibitors such as GF109203X and H89.	Staurosporine	64-77	esterase 18	Mus musculus	31-35
10037816-6	1999	In addition, ES18 transcript was induced by C2-ceramide, which is a mediator of both dexamethasone- and staurosporine-induced apoptotic signaling.	Staurosporine	104-117	esterase 18	Mus musculus	13-17
10093970-3	1999	While PYK2 tyrosine phosphorylation induced by thrombin was inhibited by preincubation of platelets with PKC inhibitors, staurosporine and Ro31-8220, PYK2 association with Src was markedly enhanced under the same conditions.	Staurosporine	121-134	protein tyrosine kinase 2 beta	Homo sapiens	6-10
10093970-3	1999	While PYK2 tyrosine phosphorylation induced by thrombin was inhibited by preincubation of platelets with PKC inhibitors, staurosporine and Ro31-8220, PYK2 association with Src was markedly enhanced under the same conditions.	Staurosporine	121-134	coagulation factor II, thrombin	Homo sapiens	47-55
10100870-5	1999	Stimulation of apoptosis by staurosporine, a protein kinase C inhibitor, reduces the LPR in Rat1-Myc cells in a dose-dependent manner.	Staurosporine	28-41	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	97-100
10100870-6	1999	The staurosporine effect on the LPR is rapid and precedes the execution phase of apoptosis as defined by caspase activation and PARP cleavage.	Staurosporine	4-17	collagen type XI alpha 2 chain	Homo sapiens	128-132
10100870-10	1999	The reduction in LPR in response to staurosporine may be an early step in the induction of apoptosis in Rat1-Myc cells.	Staurosporine	36-49	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	109-112
10100870-11	1999	By abolishing the reduction in LPR, Bcl-2 may protect Rat1-Myc cells from staurosporine-induced apoptosis.	Staurosporine	74-87	BCL2 apoptosis regulator	Homo sapiens	36-41
10100870-11	1999	By abolishing the reduction in LPR, Bcl-2 may protect Rat1-Myc cells from staurosporine-induced apoptosis.	Staurosporine	74-87	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-62
10085289-1	1999	Here we report that in staurosporine-induced apoptosis of HeLa cells, Bid, a BH3 domain containing protein, translocates from the cytosol to mitochondria.	Staurosporine	23-36	BH3 interacting domain death agonist	Homo sapiens	70-73
10037731-8	1999	A well recognized inducer of apoptosis in HEK cells, staurosporine, caused increased caspase activity and cytoplasmic cytochrome c levels in both wild-type and antisense cells.	Staurosporine	53-66	cytochrome c, somatic	Homo sapiens	118-130
10070033-10	1999	The PKC antagonists staurosporine and GF-109203X (25 ng/kg iv) reduced TNBS-induced changes in mucosal PKC activity and the degree of mucosal damage.	Staurosporine	20-33	protein kinase C, gamma	Rattus norvegicus	4-7
10096784-12	1999	Furthermore, pancreastatin produced Ser/Thr phosphorylation of insulin receptor by a staurosporine-sensitive mechanism.	Staurosporine	85-98	insulin receptor	Rattus norvegicus	63-79
10037464-1	1999	Treating SH-SY5Y human neuroblastoma cells with 1 microM staurosporine resulted in a three- to fourfold higher DNA-dependent protein kinase (DNA-PK) activity compared with untreated cells.	Staurosporine	57-70	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	111-139
10037464-1	1999	Treating SH-SY5Y human neuroblastoma cells with 1 microM staurosporine resulted in a three- to fourfold higher DNA-dependent protein kinase (DNA-PK) activity compared with untreated cells.	Staurosporine	57-70	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	141-147
10037464-2	1999	Time course studies revealed a biphasic effect of staurosporine on DNA-PK activity: an initial increase that peaked by 4 h and a rapid decline that reached approximately 5-10% that of untreated cells by 24 h of treatment.	Staurosporine	50-63	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	67-73
10037464-4	1999	The maximal stimulation of DNA-PK activity preceded significant morphological changes that occurred between 4 and 8 h (40% of total number of cells) and increased with time, reaching 70% by 48 h. Staurosporine had no effect on caspase-1 activity but stimulated caspase-3 activity by 10-15-fold in a time-dependent manner, similar to morphological changes.	Staurosporine	196-209	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	27-33
10037464-7	1999	A cell-permeable inhibitor of DNA-PK, OK-1035, significantly reduced staurosporine-induced punctate nuclear morphology and DNA fragmentation.	Staurosporine	69-82	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	30-36
10198191-5	1999	IL-1 beta-induced accumulations of VEGF mRNA in cardiac myocytes were abolished by the tyrosine kinase inhibitor genistein, whereas inhibition of protein kinase C (PKC) by staurosporin, calphostin C and phorbol ester-induced PKC depletion, and intracellular Ca2+ chelators did not affect the induction of VEGF mRNA by IL-1 beta.	Staurosporine	172-184	interleukin 1 beta	Homo sapiens	0-9
10049744-5	1999	To further characterize the factors required for formation of such a stable receptor complex we demonstrate using IFN stimulated Daudi cells that (1) IFNAR2c co-immunoprecipitates with IFNAR1 even when tyrosine phosphorylation of receptor chains is blocked with staurosporine, and (2) IFNbeta1b but not IFNalpha2, is present in the immunoprecipitated receptor complex.	Staurosporine	262-275	interferon alpha and beta receptor subunit 2	Homo sapiens	150-156
10037154-3	1999	The presence of EGF substantially reduced the in vitro Ac-DEVD-AMC hydrolytic activity and almost completely suppressed the intracellular cleavage of poly(ADP-ribose) polymerase in staurosporine- or wortmannin-treated cells.	Staurosporine	181-194	poly(ADP-ribose) polymerase 1	Homo sapiens	150-177
10037154-4	1999	Staurosporine but not wortmannin caused the intracellular proteolytic processing of pro-caspase-3 and this event was transiently inhibited by EGF.	Staurosporine	0-13	caspase 3	Homo sapiens	84-97
9950867-6	1999	NE, ET-1, and PMA inhibited the relaxant effects of KCl, and this effect was attenuated by the protein kinase C inhibitor staurosporine but not by the phospholipase A2 inhibitor quinacrine.	Staurosporine	122-135	endothelin 1	Homo sapiens	4-8
10072306-3	1999	GRP78 antisense treatment enhanced apoptosis of differentiated PC12 cells following NGF withdrawal or exposure to staurosporine.	Staurosporine	114-127	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	0-5
10098498-9	1999	Western blots demonstrated expression of PKCalpha, betaI, epsilon, delta, and zeta in H9c2 cells; PKC inhibitors (staurosporine or Ro 31-8220) or down-regulation of PKCalpha, betaI, epsilon, and delta by long-term (24 h) TPA treatment caused a partial blockade of the AVP-induced response, whereas the A23187-induced AA release was unaffected by down-regulation of these isoforms.	Staurosporine	114-127	protein kinase C, alpha	Rattus norvegicus	41-82
10098498-9	1999	Western blots demonstrated expression of PKCalpha, betaI, epsilon, delta, and zeta in H9c2 cells; PKC inhibitors (staurosporine or Ro 31-8220) or down-regulation of PKCalpha, betaI, epsilon, and delta by long-term (24 h) TPA treatment caused a partial blockade of the AVP-induced response, whereas the A23187-induced AA release was unaffected by down-regulation of these isoforms.	Staurosporine	114-127	protein kinase C, alpha	Rattus norvegicus	41-44
10323280-2	1999	The antithrombin III-stimulated release of big endothelin-1 and endothelin-1 (1.7-fold and 1.3-fold over baseline) was abolished by nicardipine (L-type Ca2+ channel blocker), heparin, and N-acetyl heparin (a derivative devoid of antithrombin affinity), whereas staurosporine and genistein (inhibitors of protein kinase C and tyrosine kinase, respectively) were ineffective.	Staurosporine	261-274	serpin family C member 1	Rattus norvegicus	4-20
10323280-2	1999	The antithrombin III-stimulated release of big endothelin-1 and endothelin-1 (1.7-fold and 1.3-fold over baseline) was abolished by nicardipine (L-type Ca2+ channel blocker), heparin, and N-acetyl heparin (a derivative devoid of antithrombin affinity), whereas staurosporine and genistein (inhibitors of protein kinase C and tyrosine kinase, respectively) were ineffective.	Staurosporine	261-274	endothelin 1	Rattus norvegicus	47-59
10323280-2	1999	The antithrombin III-stimulated release of big endothelin-1 and endothelin-1 (1.7-fold and 1.3-fold over baseline) was abolished by nicardipine (L-type Ca2+ channel blocker), heparin, and N-acetyl heparin (a derivative devoid of antithrombin affinity), whereas staurosporine and genistein (inhibitors of protein kinase C and tyrosine kinase, respectively) were ineffective.	Staurosporine	261-274	endothelin 1	Rattus norvegicus	64-76
10218741-5	1999	Stimulation of BAECs with tumor necrosis factor-alpha or transforming growth factor-beta increased ET-1 synthesis, and treatment of BAECs with 2-chloroadenosine or staurosporine caused concentration-dependent reductions in ET-1 synthesis.	Staurosporine	164-177	endothelin 1	Bos taurus	99-103
10218741-5	1999	Stimulation of BAECs with tumor necrosis factor-alpha or transforming growth factor-beta increased ET-1 synthesis, and treatment of BAECs with 2-chloroadenosine or staurosporine caused concentration-dependent reductions in ET-1 synthesis.	Staurosporine	164-177	endothelin 1	Bos taurus	223-227
10098843-6	1999	Consistent with a possible phospholipase A2-mediated mechanism, the endothelin-1 effect was blocked by calcium chelation with BAPTA-AM and was not affected by kinase inhibition by either staurosporine or genistein.	Staurosporine	187-200	endothelin 1 L homeolog	Xenopus laevis	68-80
10527458-5	1999	However, the known PKC inhibitors such as H-7 or staurosporine, partially inhibited the elevation of sAPP alpha secretion in response to protein kinase C (PKC) agonist phorbol 12,13-dibutyrate (PdBu) as well as to IL-1beta, mimicking the immunosuppressive gp41 peptide.	Staurosporine	49-62	interleukin 1 beta	Homo sapiens	214-222
9949201-7	1999	Treatment with apoptosis inhibitors rescued FRDA but not control fibroblasts from oxidant stress, and staurosporine-induced caspase 3 activity was higher in FRDA fibroblasts, consistent with the possibility that an apoptotic step upstream of caspase 3 is activated in FRDA fibroblasts.	Staurosporine	102-115	caspase 3	Homo sapiens	124-133
9949201-7	1999	Treatment with apoptosis inhibitors rescued FRDA but not control fibroblasts from oxidant stress, and staurosporine-induced caspase 3 activity was higher in FRDA fibroblasts, consistent with the possibility that an apoptotic step upstream of caspase 3 is activated in FRDA fibroblasts.	Staurosporine	102-115	frataxin	Homo sapiens	157-161
9949201-7	1999	Treatment with apoptosis inhibitors rescued FRDA but not control fibroblasts from oxidant stress, and staurosporine-induced caspase 3 activity was higher in FRDA fibroblasts, consistent with the possibility that an apoptotic step upstream of caspase 3 is activated in FRDA fibroblasts.	Staurosporine	102-115	caspase 3	Homo sapiens	242-251
9949201-7	1999	Treatment with apoptosis inhibitors rescued FRDA but not control fibroblasts from oxidant stress, and staurosporine-induced caspase 3 activity was higher in FRDA fibroblasts, consistent with the possibility that an apoptotic step upstream of caspase 3 is activated in FRDA fibroblasts.	Staurosporine	102-115	frataxin	Homo sapiens	157-161
10037491-3	1999	Treatment of microglia with A beta (25-35) at 10 nM or 12-O-tetradecanoylphorbol 13-acetate (1.6 nM) led to phosphorylation of MARCKS, an event inhibited by PKC inhibitors, staurosporine, calphostin C, and chelerythrine.	Staurosporine	173-186	amyloid beta precursor protein	Rattus norvegicus	28-34
10037491-3	1999	Treatment of microglia with A beta (25-35) at 10 nM or 12-O-tetradecanoylphorbol 13-acetate (1.6 nM) led to phosphorylation of MARCKS, an event inhibited by PKC inhibitors, staurosporine, calphostin C, and chelerythrine.	Staurosporine	173-186	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	127-133
9971736-8	1999	Upon treatment of the cells with a PKC inhibitor, staurosporin, FEZ1 was translocated from the cytoplasm to the plasma membrane, suggesting that the cytoplasmic translocation of FEZ1 is directly regulated by the PKCzeta activity.	Staurosporine	50-62	protein kinase C zeta	Homo sapiens	35-38
9971736-8	1999	Upon treatment of the cells with a PKC inhibitor, staurosporin, FEZ1 was translocated from the cytoplasm to the plasma membrane, suggesting that the cytoplasmic translocation of FEZ1 is directly regulated by the PKCzeta activity.	Staurosporine	50-62	fasciculation and elongation protein zeta 1	Rattus norvegicus	64-68
9971736-8	1999	Upon treatment of the cells with a PKC inhibitor, staurosporin, FEZ1 was translocated from the cytoplasm to the plasma membrane, suggesting that the cytoplasmic translocation of FEZ1 is directly regulated by the PKCzeta activity.	Staurosporine	50-62	fasciculation and elongation protein zeta 1	Rattus norvegicus	178-182
9971736-8	1999	Upon treatment of the cells with a PKC inhibitor, staurosporin, FEZ1 was translocated from the cytoplasm to the plasma membrane, suggesting that the cytoplasmic translocation of FEZ1 is directly regulated by the PKCzeta activity.	Staurosporine	50-62	protein kinase C, zeta	Rattus norvegicus	212-219
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	46-49
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	Staurosporine	0-13	arginine vasopressin	Homo sapiens	77-88
9925748-8	1999	Staurosporine and calphostin C, inhibitors of PKC, significantly reduced the vasopressin-induced accumulation of HSP27 and alphaB-crystallin as well as that induced by TPA.	Staurosporine	0-13	heat shock protein family B (small) member 1	Homo sapiens	113-118
9891071-1	1999	The cytosolic factor Cif (cytochrome c-efflux inducing factor) was activated by the apoptosis inducers staurosporine and anti-Fas antibodies and rapidly induced the efflux of cytochrome c from purified human mitochondria.	Staurosporine	103-116	cytochrome c, somatic	Homo sapiens	26-38
9891071-1	1999	The cytosolic factor Cif (cytochrome c-efflux inducing factor) was activated by the apoptosis inducers staurosporine and anti-Fas antibodies and rapidly induced the efflux of cytochrome c from purified human mitochondria.	Staurosporine	103-116	cytochrome c, somatic	Homo sapiens	175-187
10068151-5	1999	The stimulatory effect of phorbol 12-myristate 13-acetate (PMA) (0.1 microg/ml) on superoxide production and myeloperoxidase, which is inhibited by 100 nM staurosporine, was not affected by 100 microM ambroxol.	Staurosporine	155-168	myeloperoxidase	Mus musculus	109-124
11972170-4	1999	Protein kinase C(PKC) agonist PMA induced c-fos expression.PKC inhibitor staurosporine blocked ET-1 induced c-fos expression.	Staurosporine	73-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-47
11972170-4	1999	Protein kinase C(PKC) agonist PMA induced c-fos expression.PKC inhibitor staurosporine blocked ET-1 induced c-fos expression.	Staurosporine	73-86	endothelin 1	Rattus norvegicus	95-99
11972170-4	1999	Protein kinase C(PKC) agonist PMA induced c-fos expression.PKC inhibitor staurosporine blocked ET-1 induced c-fos expression.	Staurosporine	73-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	108-113
9935181-8	1999	Staurosporine, a potent PKC inhibitor and inducer of programmed cell death, caused the appearance of new PKC-alpha and p53 bands similar to those induced by serum starvation.	Staurosporine	0-13	cellular tumor antigen p53	Cricetulus griseus	119-122
9890971-3	1999	Bcl-2 expression conferred resistance to apoptosis induced by staurosporine and by oxidative insults including hydrogen peroxide and peroxynitrite, but was less effective in inhibition of activation-induced programmed cell death induced by concanavalin A. Concanavalin A-induced apoptosis was abated, however, in cells expressing very high levels of bcl-2.	Staurosporine	62-75	BCL2, apoptosis regulator	Rattus norvegicus	0-5
9878439-0	1999	Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine.	Staurosporine	95-108	C-terminal Src kinase	Homo sapiens	51-72
9878439-0	1999	Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine.	Staurosporine	95-108	C-terminal Src kinase	Homo sapiens	74-77
9878439-1	1999	The crystal structure of the kinase domain of C-terminal Src kinase (CSK) has been determined by molecular replacement, co-complexed with the protein kinase inhibitor staurosporine (crystals belong to the space group P21212 with a=44.5 A, b=120.6 A, c=48.3 A).	Staurosporine	167-180	C-terminal Src kinase	Homo sapiens	46-67
9878439-1	1999	The crystal structure of the kinase domain of C-terminal Src kinase (CSK) has been determined by molecular replacement, co-complexed with the protein kinase inhibitor staurosporine (crystals belong to the space group P21212 with a=44.5 A, b=120.6 A, c=48.3 A).	Staurosporine	167-180	C-terminal Src kinase	Homo sapiens	69-72
9927051-2	1999	The inhibitor of phosphomevalonate decarboxylase, sodium phenylacetate, and the protein kinase inhibitor staurosporine induced (a) release of cytochrome c from the mitochondria to the cytosol; (b) reduction in mitochondrial transmembrane potential; (c) proteolytic processing of caspase-3 and -7 but not -2; (d) cleavage of the DEVD substrate and the death substrates poly(ADP-ribose) polymerase and DNA fragmentation factor; and (e) apoptosis.	Staurosporine	105-118	cytochrome c, somatic	Homo sapiens	142-154
9927051-2	1999	The inhibitor of phosphomevalonate decarboxylase, sodium phenylacetate, and the protein kinase inhibitor staurosporine induced (a) release of cytochrome c from the mitochondria to the cytosol; (b) reduction in mitochondrial transmembrane potential; (c) proteolytic processing of caspase-3 and -7 but not -2; (d) cleavage of the DEVD substrate and the death substrates poly(ADP-ribose) polymerase and DNA fragmentation factor; and (e) apoptosis.	Staurosporine	105-118	caspase 3	Homo sapiens	279-295
9990296-4	1999	MARCKS phosphorylation was inhibited by staurosporine, bis-indolylmaleimide (a PKC-specific inhibitor), Go6983 (inhibits all isoforms except PKC mu), and a peptide from the calmodulin-binding domain of MARCKS, but was unaffected by EGTA or Go6976 (inhibits cPKCs and PKC mu).	Staurosporine	40-53	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
10728572-5	1999	In contrast, staurosporin treated PBL showed a decrease in delta psi m with cytochrome-c release and a clear caspase 3 activation.	Staurosporine	13-25	caspase 3	Homo sapiens	109-118
9987015-5	1999	Field-evoked, but not KCl-evoked, synaptic vesicle exocytosis monitored by the fluorescent vesicle probe FM2-10 was inhibited by staurosporine.	Staurosporine	129-142	neuromedin U receptor 2	Rattus norvegicus	105-111
9950264-6	1999	ATA and IL-3 induced proliferation was inhibited by the kinase inhibitors genistein, staurosporine and H-7.	Staurosporine	85-98	interleukin 3	Mus musculus	8-12
10222418-1	1999	Recent studies in our laboratory have shown that UCN-01 (7-hydroxystaurosporine), which is a derivative of the non-selective protein kinase inhibitor staurosporine that exhibits relative selectivity for protein kinase C (PKC), is a potent inhibitor of glioma growth in in vitro and in vivo models.	Staurosporine	66-79	urocortin	Homo sapiens	49-52
10222418-1	1999	Recent studies in our laboratory have shown that UCN-01 (7-hydroxystaurosporine), which is a derivative of the non-selective protein kinase inhibitor staurosporine that exhibits relative selectivity for protein kinase C (PKC), is a potent inhibitor of glioma growth in in vitro and in vivo models.	Staurosporine	66-79	proline rich transmembrane protein 2	Homo sapiens	203-219
10222418-1	1999	Recent studies in our laboratory have shown that UCN-01 (7-hydroxystaurosporine), which is a derivative of the non-selective protein kinase inhibitor staurosporine that exhibits relative selectivity for protein kinase C (PKC), is a potent inhibitor of glioma growth in in vitro and in vivo models.	Staurosporine	66-79	proline rich transmembrane protein 2	Homo sapiens	221-224
9892013-14	1999	IL-4 induction of 3beta-HSD mRNA and activity is sensitive to staurosporine.	Staurosporine	62-75	interleukin 4	Homo sapiens	0-4
9892013-14	1999	IL-4 induction of 3beta-HSD mRNA and activity is sensitive to staurosporine.	Staurosporine	62-75	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	18-27
10325544-5	1999	As measured by the MTT reduction assay after treatment with staurosporine, the survival rate of BCEN/bcl-2 cells was 48.0 +/- 4.8% compared to 7.4 +/- 2.1% in control BCEN cells.	Staurosporine	60-73	BCL2 apoptosis regulator	Bos taurus	101-106
10325544-6	1999	As determined by light microscopy, apoptotic changes such as nuclear condensation and apoptotic bodies were largely attenuated in BCEN/bcl-2 cells after staurosporine treatment although arborization of processes and rounding up of the cell body were not affected by overexpression of bcl-2.	Staurosporine	153-166	BCL2 apoptosis regulator	Bos taurus	135-140
10325544-6	1999	As determined by light microscopy, apoptotic changes such as nuclear condensation and apoptotic bodies were largely attenuated in BCEN/bcl-2 cells after staurosporine treatment although arborization of processes and rounding up of the cell body were not affected by overexpression of bcl-2.	Staurosporine	153-166	BCL2 apoptosis regulator	Bos taurus	284-289
10325544-7	1999	These results suggest that staurosporine induces apoptosis in a cycloheximide-independent but caspase-dependent manner and bcl-2 acts as a negative regulator in staurosporine-induced apoptosis of BCEN cells.	Staurosporine	161-174	BCL2 apoptosis regulator	Bos taurus	123-128
10604280-4	1999	Pretreatment with 1 microM calphostin C or 20 nM staurosporine caused marked reductions in contractions induced by ET-1 and U46619 in both control and diabetic aortas, and the difference in the maximum contractile responses to these agonists between control and diabetic aortas were eliminated by their treatment.	Staurosporine	49-62	endothelin 1	Rattus norvegicus	115-119
10458519-8	1999	Similarly, staurosporine (10(-7) mol/l) and calphostin C (10(-6) mol/l), inhibitors of protein kinase C (PKC), diminished basal tone and abolished the ANP-response in HR thoracic aorta.	Staurosporine	11-24	natriuretic peptide A	Rattus norvegicus	151-154
9852041-3	1998	During staurosporine (STS)-induced cell death, beta-catenin and PS1-CTF undergo a caspase-mediated cleavage.	Staurosporine	7-20	catenin beta 1	Homo sapiens	47-59
9852041-3	1998	During staurosporine (STS)-induced cell death, beta-catenin and PS1-CTF undergo a caspase-mediated cleavage.	Staurosporine	7-20	presenilin 1	Homo sapiens	64-67
9852041-3	1998	During staurosporine (STS)-induced cell death, beta-catenin and PS1-CTF undergo a caspase-mediated cleavage.	Staurosporine	22-25	catenin beta 1	Homo sapiens	47-59
9852041-3	1998	During staurosporine (STS)-induced cell death, beta-catenin and PS1-CTF undergo a caspase-mediated cleavage.	Staurosporine	22-25	presenilin 1	Homo sapiens	64-67
9852041-4	1998	After 12 h of STS treatment, the beta-catenin.PS1-CTF interaction is abrogated.	Staurosporine	14-17	catenin beta 1	Homo sapiens	33-45
9852041-4	1998	After 12 h of STS treatment, the beta-catenin.PS1-CTF interaction is abrogated.	Staurosporine	14-17	presenilin 1	Homo sapiens	46-49
9827702-3	1998	Nuclear protein kinase activity was significantly decreased in the presence of EGTA (1.0 mM), trifluoperazine (TFP; 20 microM), dibucaine (10(-4) M), or staurosporine (10(-7) M), indicating that Ca2+-dependent protein kinases are present in the nuclei.	Staurosporine	153-166	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	8-22
9827702-5	1998	Hepatectomy-increased nuclear protein kinase activity was significantly decreased in the presence of EGTA (1.0 mM), TFP (20 microM), or staurosporine (10(-7) M) in the enzyme reaction mixture.	Staurosporine	136-149	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	30-44
9874176-8	1998	Staurosporine but not genistein inhibited this effect of angiotensin II.	Staurosporine	0-13	angiotensinogen	Rattus norvegicus	57-71
9856857-11	1998	Staurosporine (a potent inducer of apoptosis in many cell types) effectively induced neuronal cell death in wild-type, p53-deficient and Bax-deficient hippocampal neurons, indicating that all were competent to undergo programmed cell death.	Staurosporine	0-13	transformation related protein 53, pseudogene	Mus musculus	119-122
9856857-11	1998	Staurosporine (a potent inducer of apoptosis in many cell types) effectively induced neuronal cell death in wild-type, p53-deficient and Bax-deficient hippocampal neurons, indicating that all were competent to undergo programmed cell death.	Staurosporine	0-13	BCL2-associated X protein	Mus musculus	137-140
14646477-4	1998	Staurosporine (1.0 microM) rapidly induced phosphatidylserine plasma membrane translocation that increased linearly with time as measured by annexin V-FITC binding, and similar kinetics were observed for caspase activation by staurosporine in BG-1 cells.	Staurosporine	0-13	annexin A5	Homo sapiens	141-150
10022774-6	1998	The suppression by TPA preincubation of the rhFSH-induced cAMP synthesis was completely abolished by the protein kinase C (PKC) inhibitor staurosporine (STR).	Staurosporine	138-151	protein kinase C beta	Homo sapiens	123-126
9884090-5	1998	Treatment of cells with staurosporine and Ro 31-8220 inhibited the PMA-induced potentiation of both AA release and cyclic AMP accumulation, while Go 6976 (an inhibitor of classical PKC isoforms) and LY 379196 (a specific inhibitor of PKCbeta) inhibited the AA response but failed to affect the enhancement of the cyclic AMP response by PMA.	Staurosporine	24-37	protein kinase C, alpha	Mus musculus	181-184
9884090-5	1998	Treatment of cells with staurosporine and Ro 31-8220 inhibited the PMA-induced potentiation of both AA release and cyclic AMP accumulation, while Go 6976 (an inhibitor of classical PKC isoforms) and LY 379196 (a specific inhibitor of PKCbeta) inhibited the AA response but failed to affect the enhancement of the cyclic AMP response by PMA.	Staurosporine	24-37	protein kinase C, beta	Mus musculus	234-241
9822738-7	1998	Expression of PS-1 protected against induction of apoptosis in the cortical neurons by etoposide or staurosporine.	Staurosporine	100-113	presenilin 1	Homo sapiens	14-18
10069703-4	1998	The changes in Na+, K+-ATPase activity induced by PDBu and PMA were prevented by staurosporine, a PKC inhibitor.	Staurosporine	81-94	protein kinase C, gamma	Rattus norvegicus	98-101
9828096-2	1998	Effects on the cell cycle were compared with those induced by the kinase inhibitor staurosporine, which arrests normal cells in early G1 phase by acting upstream of CDK2.	Staurosporine	83-96	cyclin dependent kinase 2	Homo sapiens	165-169
9827570-6	1998	The inhibitory effect of PMA was attenuated in the presence of staurosporine, suggesting that OAT1 is regulated by protein kinase C. These results suggest that the substrate recognition of OAT1 is comparable to that of renal basolateral organic anion transporter, and the transport activity is regulated by protein kinase C.	Staurosporine	63-76	solute carrier family 22 member 6	Rattus norvegicus	94-98
9827570-6	1998	The inhibitory effect of PMA was attenuated in the presence of staurosporine, suggesting that OAT1 is regulated by protein kinase C. These results suggest that the substrate recognition of OAT1 is comparable to that of renal basolateral organic anion transporter, and the transport activity is regulated by protein kinase C.	Staurosporine	63-76	solute carrier family 22 member 6	Rattus norvegicus	189-193
9860239-6	1998	We found that ECP release induced by SOS was inhibited by the PKC inhibitors staurosporine and calphostin C.	Staurosporine	77-90	ribonuclease A family member 3	Homo sapiens	14-17
9799222-3	1998	The expression levels of Hsp70 in the cells obtained correlated well with their survival following treatments with tumor necrosis factor, staurosporine and doxorubicin.	Staurosporine	138-151	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
9815136-4	1998	The increase in luminal fluorescence caused by staurosporine was blocked by the p-glycoprotein substrate, CSA, indicating that this component of transport was indeed mediated by p-glycoprotein.	Staurosporine	47-60	ATP binding cassette subfamily B member 1	Homo sapiens	80-94
9815136-4	1998	The increase in luminal fluorescence caused by staurosporine was blocked by the p-glycoprotein substrate, CSA, indicating that this component of transport was indeed mediated by p-glycoprotein.	Staurosporine	47-60	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	106-109
9815136-4	1998	The increase in luminal fluorescence caused by staurosporine was blocked by the p-glycoprotein substrate, CSA, indicating that this component of transport was indeed mediated by p-glycoprotein.	Staurosporine	47-60	ATP binding cassette subfamily B member 1	Homo sapiens	178-192
9860239-6	1998	We found that ECP release induced by SOS was inhibited by the PKC inhibitors staurosporine and calphostin C.	Staurosporine	77-90	proline rich transmembrane protein 2	Homo sapiens	62-65
9779822-8	1998	This phosphorylation of c-jun was inhibited by staurosporine.	Staurosporine	47-60	jun proto-oncogene	Mus musculus	24-29
9820166-5	1998	The thrombin-enhanced PCA depended on the activation of protein kinase C (PKC) as it was diminished by staurosporine and calphostin C.	Staurosporine	103-116	coagulation factor II, thrombin	Homo sapiens	4-12
9925381-4	1998	The inhibitors of protein kinase C activity (staurosporine) but not calcium/calmodulin (trifluoperazine) attenuated the iNOS activity.	Staurosporine	45-58	nitric oxide synthase 2, inducible	Mus musculus	120-124
9788881-4	1998	Okadaic acid-induced entry into mitosis is accompanied by partial activation of Cdc25C and may be prevented by tyrosine phosphatase inhibitors and by the protein kinase inhibitor staurosporine, suggesting that Cdc25C and kinases distinct from Cdc2 are required for these mitotic events.	Staurosporine	179-192	cell division cycle 25C	Mus musculus	80-86
9788881-4	1998	Okadaic acid-induced entry into mitosis is accompanied by partial activation of Cdc25C and may be prevented by tyrosine phosphatase inhibitors and by the protein kinase inhibitor staurosporine, suggesting that Cdc25C and kinases distinct from Cdc2 are required for these mitotic events.	Staurosporine	179-192	cell division cycle 25C	Mus musculus	210-216
9788881-4	1998	Okadaic acid-induced entry into mitosis is accompanied by partial activation of Cdc25C and may be prevented by tyrosine phosphatase inhibitors and by the protein kinase inhibitor staurosporine, suggesting that Cdc25C and kinases distinct from Cdc2 are required for these mitotic events.	Staurosporine	179-192	cyclin-dependent kinase 1	Mus musculus	80-84
9795359-8	1998	Staurosporine, a PKC inhibitor, inhibited progesterone secretion stimulated by the combined action of LDL and PRL; however, such inhibition was not demonstrated when cells were treated with the PKC inhibitor, H-7.	Staurosporine	0-13	prolactin	Sus scrofa	110-113
9858317-6	1998	Overexpression of human RNase L greatly enhanced both the cell growth inhibitory activity of IFN and the proapoptotic activity of staurosporine.	Staurosporine	130-143	ribonuclease L	Homo sapiens	24-31
9824485-3	1998	We performed an analysis of the mechanisms by which two PKC inhibitors, Calphostin C and Staurosporine, prevent the FN-induced IL-1beta response.	Staurosporine	89-102	interleukin 1 beta	Homo sapiens	127-135
9855300-7	1998	The desensitization by TPA or Abeta (25-35) was inhibited when staurosporine was present in the pretreatment media.	Staurosporine	63-76	amyloid beta precursor protein	Homo sapiens	30-35
9792795-4	1998	A FL5.12 Bax CL16 mutant cell, ms3, which is resistant to apoptosis induced by staurosporine, retains the activity of Bax redistribution but shows no caspase-3 activity.	Staurosporine	79-92	BCL2-associated X protein	Mus musculus	9-12
9763465-0	1998	Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.	Staurosporine	0-13	caspase 1	Rattus norvegicus	77-86
9763465-5	1998	We then prepared extracts from staurosporine-treated hippocampal neurons and monitored cleavage of acetyl-Tyr-Val-Ala-Asp-aminomethyl-coumarin and acetyl-Asp-Glu-Val-Asp-AMC, fluorogenic substrates for caspase-1-like and caspase-3-like proteases, respectively.	Staurosporine	31-44	caspase 1	Rattus norvegicus	202-211
9763465-5	1998	We then prepared extracts from staurosporine-treated hippocampal neurons and monitored cleavage of acetyl-Tyr-Val-Ala-Asp-aminomethyl-coumarin and acetyl-Asp-Glu-Val-Asp-AMC, fluorogenic substrates for caspase-1-like and caspase-3-like proteases, respectively.	Staurosporine	31-44	caspase-3-like	Rattus norvegicus	221-235
9763465-6	1998	Staurosporine caused a significant increase in caspase-1-like activity that preceded intracellular superoxide production and reached a maximum after 30 min.	Staurosporine	0-13	caspase 1	Rattus norvegicus	47-56
9763465-8	1998	Treatment with the corresponding caspase-3-like protease inhibitor acetyl-Asp-Glu-Val-Asp-aldehyde (10 microM) prevented the increase in caspase-3-like activity and staurosporine-induced nuclear fragmentation, but failed to prevent the rise in superoxide production and subsequent cell death.	Staurosporine	165-178	caspase-3-like	Rattus norvegicus	33-47
9763465-11	1998	These results suggest a scenario of an early, caspase-1-like activity followed by a delayed intracellular superoxide production that mediates staurosporine-induced cell death of cultured rat hippocampal neurons.	Staurosporine	142-155	caspase 1	Rattus norvegicus	46-55
9756886-9	1998	We attempted to model staurosporine in the ATP-binding site of CDK4 according to our kinetic data.	Staurosporine	22-35	cyclin dependent kinase 4	Homo sapiens	63-67
9754656-8	1998	Further, the differentiation of p55 transfectants induced by TNF was reduced by the inhibitor of protein-kinase-C (PKC), staurosporine.	Staurosporine	121-134	TNF receptor superfamily member 1A	Homo sapiens	32-35
9754656-8	1998	Further, the differentiation of p55 transfectants induced by TNF was reduced by the inhibitor of protein-kinase-C (PKC), staurosporine.	Staurosporine	121-134	tumor necrosis factor	Homo sapiens	61-64
9755111-7	1998	Furthermore, protection by KGF was completely blocked by 1) genistein, a tyrosine kinase inhibitor; 2) staurosporine and calphostin C, protein kinase C (PKC) inhibitors; and 3) aphidicolin, butylphenyl dGTP, and 2",3"-dideoxythymidine 5"-triphosphate, inhibitors of DNA polymerase.	Staurosporine	103-116	fibroblast growth factor 7	Rattus norvegicus	27-30
9757037-3	1998	The pretreatment with staurosporine (1 microM) completely inhibited the increase of PGE2-induced proENK mRNA level, although only a partial inhibition of PGE2-induced proENK mRNA level (approximately 1.5-fold) by H89 (10 microM) was observed.	Staurosporine	22-35	proenkephalin	Rattus norvegicus	97-103
9831895-9	1998	Prior treatment of TECs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate BK-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Staurosporine	29-42	kininogen 1	Canis lupus familiaris	114-116
9799125-4	1998	p21WAF1/CIP1 translated in vitro was cleaved into a p14 fragment when incubated with cell extracts obtained from either ginsenoside Rh2-treated or staurosporine-treated cells.	Staurosporine	147-160	cyclin dependent kinase inhibitor 1A	Homo sapiens	8-12
9799125-4	1998	p21WAF1/CIP1 translated in vitro was cleaved into a p14 fragment when incubated with cell extracts obtained from either ginsenoside Rh2-treated or staurosporine-treated cells.	Staurosporine	147-160	ribonuclease P/MRP subunit p14	Homo sapiens	52-55
9763633-10	1998	Whole-cell patch-clamp studies demonstrated that neomycin and PKC blockers such as staurosporine and H7 inhibited volume-sensitive chloride currents.	Staurosporine	83-96	proline rich transmembrane protein 2	Homo sapiens	62-65
9780207-6	1998	Staurosporine blocked the inhibitory effect of gp120 on monocytes, suggesting that cellular signaling was required for gp120 to inhibit the response of CD4+ cells to chemoattractants.	Staurosporine	0-13	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	47-52
9780207-6	1998	Staurosporine blocked the inhibitory effect of gp120 on monocytes, suggesting that cellular signaling was required for gp120 to inhibit the response of CD4+ cells to chemoattractants.	Staurosporine	0-13	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	119-124
9780207-6	1998	Staurosporine blocked the inhibitory effect of gp120 on monocytes, suggesting that cellular signaling was required for gp120 to inhibit the response of CD4+ cells to chemoattractants.	Staurosporine	0-13	CD4 molecule	Homo sapiens	152-155
9821807-0	1998	Effects of genistein and staurosporine on angiotensin II-induced DNA synthesis, protein synthesis and mitogen-activated protein kinase activation in vascular smooth muscle cells.	Staurosporine	25-38	angiotensinogen	Rattus norvegicus	42-56
9821807-4	1998	The protein kinase C inhibitors staurosporine and calphostin C caused an inhibition of the angiotensin II-induced protein synthesis but not of the agent-induced DNA synthesis.	Staurosporine	32-45	angiotensinogen	Rattus norvegicus	91-105
9821807-6	1998	Angiotensin II stimulated mitogen-activated protein (MAP) kinases and the angiotensin II-induced MAP kinase activation was inhibited by genistein but not by staurosporine.	Staurosporine	157-170	angiotensinogen	Rattus norvegicus	74-88
9831916-9	1998	Pretreatment with staurosporine (100 nM) prevented desensitization of ET(A)R in the rat RA altogether.	Staurosporine	18-31	endothelin receptor type A	Rattus norvegicus	70-76
10100885-9	1998	In contrast, staurosporine and GF109203X, protein kinase C inhibitors, reduced the synergistic augmentation induced by PMA and FMLP.	Staurosporine	13-26	formyl peptide receptor 1	Homo sapiens	127-131
9824485-9	1998	In contrast, Staurosporine alone induced AP-1 translocation and stimulation of the gene.	Staurosporine	13-26	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	41-45
9824485-12	1998	In contrast, Staurosporine prevented secretion of IL-1beta by unknown mechanisms.	Staurosporine	13-26	interleukin 1 beta	Homo sapiens	50-58
9768673-8	1998	The PMA-induced increase in leptin production was completely suppressed by H7 and staurosporine, both of which are inhibitors of protein kinase C. Leptin secretion from first trimester chorionic tissue was approximately 50-fold greater than that from term placental tissue.	Staurosporine	82-95	leptin	Homo sapiens	28-34
9768673-8	1998	The PMA-induced increase in leptin production was completely suppressed by H7 and staurosporine, both of which are inhibitors of protein kinase C. Leptin secretion from first trimester chorionic tissue was approximately 50-fold greater than that from term placental tissue.	Staurosporine	82-95	leptin	Homo sapiens	147-153
9766631-5	1998	Effects of interleukin-4 and of phorbol 12-myristate 13-acetate on CD134 expression could be blocked by the protein kinase inhibitor staurosporin.	Staurosporine	133-145	interleukin 4	Homo sapiens	11-24
9766631-5	1998	Effects of interleukin-4 and of phorbol 12-myristate 13-acetate on CD134 expression could be blocked by the protein kinase inhibitor staurosporin.	Staurosporine	133-145	TNF receptor superfamily member 4	Homo sapiens	67-72
9751706-1	1998	PKN, a fatty acid- and Rho-activated serine/threonine kinase having a catalytic domain highly homologous to protein kinase C (PKC), was cleaved at specific sites in apoptotic Jurkat and U937 cells on Fas ligation and treatment with staurosporin or etoposide, respectively.	Staurosporine	232-244	protein kinase N1	Homo sapiens	0-3
9743582-0	1998	The accumulation of cyclin-dependent kinase inhibitor p27kip1 is a primary response to staurosporine and independent of G1 cell cycle arrest.	Staurosporine	87-100	cyclin-dependent kinase inhibitor 1B	Mus musculus	54-61
9743582-2	1998	All the cell lines which were sensitive to staurosporine-induced G1 arrest contained a functional retinoblastoma protein (pRB).	Staurosporine	43-56	RB transcriptional corepressor 1	Mus musculus	122-125
9743582-4	1998	In searching for a common event caused by staurosporine, the cyclin-dependent kinase (CDK) inhibitor protein p27kip1 but not p21cip1 was found to accumulate after staurosporine treatment in all the cell lines examined.	Staurosporine	42-55	cyclin-dependent kinase inhibitor 1B	Mus musculus	109-116
9743582-4	1998	In searching for a common event caused by staurosporine, the cyclin-dependent kinase (CDK) inhibitor protein p27kip1 but not p21cip1 was found to accumulate after staurosporine treatment in all the cell lines examined.	Staurosporine	163-176	cyclin-dependent kinase inhibitor 1B	Mus musculus	109-116
9743582-6	1998	The result indicates that the accumulation of p27kip1 is the cell"s primary response to staurosporine and that the capability of staurosporine to induce G1 arrest depends on the integrity of cell cycle regulatory components which are downstream of p27kip1.	Staurosporine	88-101	cyclin-dependent kinase inhibitor 1B	Mus musculus	46-53
9743582-6	1998	The result indicates that the accumulation of p27kip1 is the cell"s primary response to staurosporine and that the capability of staurosporine to induce G1 arrest depends on the integrity of cell cycle regulatory components which are downstream of p27kip1.	Staurosporine	129-142	cyclin-dependent kinase inhibitor 1B	Mus musculus	248-255
9788587-5	1998	Incubation with Cd2+ induced a bell-shaped concentration response curve with a 2-fold increase of the PAH transport at a Cd2+ concentration of 10(-6) M. Since Cd2+ has been described to activate protein kinase C (PKC), the effects of the PKC inhibitor staurosporine were also tested.	Staurosporine	252-265	T-cell surface antigen CD2	Oryctolagus cuniculus	16-19
9730899-7	1998	Prevention of ATP production completely inhibited caspase activation and apoptosis in response to chemotherapeutic drugs and staurosporine.	Staurosporine	125-138	caspase 8	Homo sapiens	50-57
9728056-6	1998	The protein kinase C (PKC) inhibitor staurosporine (10-50 nM) inhibited PMA-induced eotaxin mRNA expression, whereas TNF-alpha-induced expression was enhanced by this reagent.	Staurosporine	37-50	C-C motif chemokine ligand 11	Homo sapiens	84-91
9729508-0	1998	PMA and staurosporine affect expression of the PCK gene in LLC-PK1-F+ cells.	Staurosporine	8-21	pyruvate kinase L/R	Homo sapiens	63-66
9729508-4	1998	The effect of PMA was reversed by staurosporine, which apparently acts by inhibiting a signaling pathway other than protein kinase C. Staurosporine had no effect on the half-life of the PCK mRNA, but it stimulated the activity of a chloramphenicol acetyltransferase gene that was driven by the initial 490 base pairs of the PCK promoter and transiently transfected into LLC-PK1-F+ cells.	Staurosporine	34-47	pyruvate kinase L/R	Homo sapiens	374-377
9729508-4	1998	The effect of PMA was reversed by staurosporine, which apparently acts by inhibiting a signaling pathway other than protein kinase C. Staurosporine had no effect on the half-life of the PCK mRNA, but it stimulated the activity of a chloramphenicol acetyltransferase gene that was driven by the initial 490 base pairs of the PCK promoter and transiently transfected into LLC-PK1-F+ cells.	Staurosporine	134-147	pyruvate kinase L/R	Homo sapiens	374-377
9730948-7	1998	Staurosporine, but not H-89, inhibited CFTR activation and in vivo phosphorylation at low PGF concentrations.	Staurosporine	0-13	cystic fibrosis transmembrane conductance regulator	Mus musculus	39-43
9784837-6	1998	TPA-repressed Topo II alpha mRNA and ATF levels were partially restored after pretreatment of staurosporin.	Staurosporine	94-106	plasminogen activator, tissue type	Homo sapiens	0-3
9861301-9	1998	These responses to ET-1 were abolished by the incubation of myocytes with an ETA receptor antagonist (BQ123) or a protein kinase C (PKC) inhibitor (H-7 or staurosporine).	Staurosporine	155-168	endothelin 1	Rattus norvegicus	19-23
9784029-7	1998	Only staurosporine at 1 microM inhibited the thrombin effect by about 75%.	Staurosporine	5-18	coagulation factor II, thrombin	Homo sapiens	45-53
9725917-5	1998	In contrast, staurosporine and KT5926, an inhibitor of myosin light chain kinase, effectively blocked thrombin-induced cell rounding and retraction.	Staurosporine	13-26	myosin light chain kinase	Homo sapiens	55-80
9799125-9	1998	Taken together, these results show that ginsenoside Rh2 and staurosporine increase caspase-3 activity, which in turn directly cleaves p21WAF1/CIP1 during the early stages of apoptosis.	Staurosporine	60-73	caspase 3	Homo sapiens	83-92
9799125-9	1998	Taken together, these results show that ginsenoside Rh2 and staurosporine increase caspase-3 activity, which in turn directly cleaves p21WAF1/CIP1 during the early stages of apoptosis.	Staurosporine	60-73	cyclin dependent kinase inhibitor 1A	Homo sapiens	134-146
9704884-3	1998	As with both native neuronal and cloned DATs, acute exposure of hDAT expressing Sf9 cells to the PKC activator PMA (1 microM), but not alphaPDD, reduced the Vmax (approximately 1 pmol/min/10(5) cells) for [3H]DA uptake by approximately 40%, an effect which was blocked by the protein kinase inhibitor staurosporine.	Staurosporine	301-314	solute carrier family 6 member 3	Homo sapiens	64-68
9705215-8	1998	The phosphorylation of these proteins decreased in the presence of staurosporine, which also supported PKC-mediated phosphorylation.	Staurosporine	67-80	protein kinase C, alpha	Rattus norvegicus	103-106
9688598-5	1998	Two broad protein kinase C (PKC) kinase inhibitors, staurosporine and calphostin C, also abolished the NPY-induced decrease in CBF.	Staurosporine	52-65	neuropeptide Y	Homo sapiens	103-106
9698608-10	1998	Protein kinase inhibition by staurosporine largely reversed heterologous beta2AR desensitization and had a small but significant effect on homologous desensitization.	Staurosporine	29-42	adrenoceptor beta 2	Homo sapiens	73-80
9792443-7	1998	We further characterized the kinase inhibitory activity of olomoucine, staurosporine, and SB 203580 for JNK2, ERK2, and p38.	Staurosporine	71-84	mitogen-activated protein kinase 9	Homo sapiens	104-108
9792443-7	1998	We further characterized the kinase inhibitory activity of olomoucine, staurosporine, and SB 203580 for JNK2, ERK2, and p38.	Staurosporine	71-84	mitogen-activated protein kinase 1	Homo sapiens	110-114
9792443-7	1998	We further characterized the kinase inhibitory activity of olomoucine, staurosporine, and SB 203580 for JNK2, ERK2, and p38.	Staurosporine	71-84	mitogen-activated protein kinase 1	Homo sapiens	120-123
9754866-5	1998	TNF-alpha release was inhibited by treatment with protein kinase C inhibitors (staurosporine, Ro31-8220, calophostin C) (p &lt; or = 0.05).	Staurosporine	79-92	tumor necrosis factor	Rattus norvegicus	0-9
9776585-12	1998	Staurosporine (10(-5) M) treatment of eosinophils maintained in IL-5 or GM-CSF resulted in significant levels of apoptotic morphology at 2 h (23.8% +/- 6.9, p &lt; 0.025) which was associated with negligible annexin binding.	Staurosporine	0-13	interleukin 5	Homo sapiens	64-68
9776585-12	1998	Staurosporine (10(-5) M) treatment of eosinophils maintained in IL-5 or GM-CSF resulted in significant levels of apoptotic morphology at 2 h (23.8% +/- 6.9, p &lt; 0.025) which was associated with negligible annexin binding.	Staurosporine	0-13	colony stimulating factor 2	Homo sapiens	72-78
9737934-6	1998	Staurosporine and chelerythrine, protein kinase C (PKC) inhibitors at 1 and 100 nm, respectively, prevented the AngII-mediated desensitization of C-ANF 4-23-sensitive adenylyl cyclase.	Staurosporine	0-13	angiotensinogen	Homo sapiens	112-117
9737934-7	1998	In addition, the AngII-mediated phosphorylation of Gialpha2 protein was also inhibited partially by about 35% by staurosporine treatment.	Staurosporine	113-126	angiotensinogen	Homo sapiens	17-22
11324551-3	1998	This effect of Ang II could be abolished by losartan (10 mumol/L), verapamil (1 mumol/L) or staurosporine (10 nmol/L).	Staurosporine	92-105	angiotensinogen	Rattus norvegicus	15-21
9706147-6	1998	This effect persisted after 24 hours and was abrogated by the PKC inhibitor staurosporine.	Staurosporine	76-89	proline rich transmembrane protein 2	Homo sapiens	62-65
9677361-4	1998	The PKC inhibitors (staurosporine, Ro 31-8220, Go 6976, and calphostin C) also inhibited LPS-induced NO release and iNOS expression.	Staurosporine	20-33	protein kinase C eta	Homo sapiens	4-7
9677361-4	1998	The PKC inhibitors (staurosporine, Ro 31-8220, Go 6976, and calphostin C) also inhibited LPS-induced NO release and iNOS expression.	Staurosporine	20-33	nitric oxide synthase 2	Homo sapiens	116-120
9668048-11	1998	Phorbol ester-mediated inhibition of PEPCK transcription was blocked by bisindole maleimide and by staurosporine, but insulin-mediated inhibition was unaffected.	Staurosporine	99-112	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	37-42
9668078-13	1998	In contrast, the serine/threonine kinase inhibitor staurosporine, but not the tyrosine kinase inhibitor genistein, led to rapid dephosphorylation of phosphorylated Bcl-2 and accelerated the progression of nocodazole M phase-arrested cells into interphase.	Staurosporine	51-64	BCL2 apoptosis regulator	Homo sapiens	164-169
9679150-5	1998	The small subset of Bcl-2-positive C2C12 cells appeared to resist staurosporine-induced apoptosis.	Staurosporine	66-79	B cell leukemia/lymphoma 2	Mus musculus	20-25
9665796-3	1998	It has been claimed that inhibition of an OA-sensitive phosphatase, possibly of PP1, induces activation of a kinase which is sensitive to staurosporine and Zn2+.	Staurosporine	138-151	inorganic pyrophosphatase 1	Homo sapiens	80-83
9639395-1	1998	It has been shown previously that the staurosporine derivative CGP 41251, a specific inhibitor of protein kinase C (IC50 = 50 nM), exhibits antitumor activity and reverses mdr1 mediated multidrug resistance.	Staurosporine	38-51	ATP binding cassette subfamily B member 1	Homo sapiens	172-176
9703866-0	1998	Treatment of human glioblastoma cells with the staurosporine derivative CGP 41251 inhibits CDC2 and CDK2 kinase activity and increases radiation sensitivity.	Staurosporine	47-60	cyclin dependent kinase 1	Homo sapiens	91-95
9725917-5	1998	In contrast, staurosporine and KT5926, an inhibitor of myosin light chain kinase, effectively blocked thrombin-induced cell rounding and retraction.	Staurosporine	13-26	coagulation factor II, thrombin	Homo sapiens	102-110
9698090-0	1998	Effect of staurosporine on transcription factor NF-kappaB in human keratinocytes.	Staurosporine	10-23	nuclear factor kappa B subunit 1	Homo sapiens	48-57
9698090-2	1998	Previously, we showed that the protein kinase inhibitor staurosporine potentiates IL-1-stimulated IL-8 production in human keratinocytes.	Staurosporine	56-69	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
9698090-3	1998	Moreover, recent studies by other investigators demonstrated that staurosporine treatment alone results in a concentration-dependent increase in IL-8 mRNA and protein production.	Staurosporine	66-79	C-X-C motif chemokine ligand 8	Homo sapiens	145-149
9698090-4	1998	Therefore, in order to understand the mechanism underlying this observation, the effect of staurosporine on the activation of NF-kappaB was investigated.	Staurosporine	91-104	nuclear factor kappa B subunit 1	Homo sapiens	126-135
9698090-5	1998	Electrophoretic mobility shift assays using an oligonucleotide containing the NF-kappaB consensus motif demonstrated that staurosporine treatment resulted in the activation of NF-kappaB by 15 min post-treatment.	Staurosporine	122-135	nuclear factor kappa B subunit 1	Homo sapiens	78-87
9698090-5	1998	Electrophoretic mobility shift assays using an oligonucleotide containing the NF-kappaB consensus motif demonstrated that staurosporine treatment resulted in the activation of NF-kappaB by 15 min post-treatment.	Staurosporine	122-135	nuclear factor kappa B subunit 1	Homo sapiens	176-185
9698090-6	1998	The ability of staurosporine to activate NF-kappaB was investigated further, using luciferase reporters under the control of the HIV-LTR or IL-8 core promoter transfected into human U937 cells.	Staurosporine	15-28	nuclear factor kappa B subunit 1	Homo sapiens	41-50
9698090-6	1998	The ability of staurosporine to activate NF-kappaB was investigated further, using luciferase reporters under the control of the HIV-LTR or IL-8 core promoter transfected into human U937 cells.	Staurosporine	15-28	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
9698090-9	1998	The mechanism underlying NF-kappaB activation does not appear to involve the classical activation pathways in that staurosporine does not induce the disappearance of IkappaB family members.	Staurosporine	115-128	nuclear factor kappa B subunit 1	Homo sapiens	25-34
9698090-10	1998	In conclusion, staurosporine appears to stimulate the activation of NF-kappaB in at least two cell types, and this effect appears to be independent of protein kinase C.	Staurosporine	15-28	nuclear factor kappa B subunit 1	Homo sapiens	68-77
9624143-3	1998	Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells resulted in cleavage of the death substrates PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45, but not alpha-fodrin.	Staurosporine	26-39	caspase 3	Homo sapiens	61-70
9720220-1	1998	Staurosporine is a potent inhibitor of protein kinase C. To identify the genes that functionally interact with the Pkc1 pathway of the yeast Saccharomyces cerevisiae, we screened for the genes that cause induced staurosporine sensitivity when overexpressed from a galactose-inducible promoter.	Staurosporine	0-13	protein kinase C	Saccharomyces cerevisiae S288C	115-119
9720220-1	1998	Staurosporine is a potent inhibitor of protein kinase C. To identify the genes that functionally interact with the Pkc1 pathway of the yeast Saccharomyces cerevisiae, we screened for the genes that cause induced staurosporine sensitivity when overexpressed from a galactose-inducible promoter.	Staurosporine	212-225	protein kinase C	Saccharomyces cerevisiae S288C	115-119
9720220-3	1998	Drug sensitivity induced by ISR1 overexpression is specific to staurosporine.	Staurosporine	63-76	putative protein kinase ISR1	Saccharomyces cerevisiae S288C	28-32
9624143-3	1998	Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells resulted in cleavage of the death substrates PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45, but not alpha-fodrin.	Staurosporine	26-39	collagen type XI alpha 2 chain	Homo sapiens	138-142
9624143-3	1998	Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells resulted in cleavage of the death substrates PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45, but not alpha-fodrin.	Staurosporine	26-39	p21 (RAC1) activated kinase 2	Homo sapiens	148-152
9624143-3	1998	Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells resulted in cleavage of the death substrates PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45, but not alpha-fodrin.	Staurosporine	26-39	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	154-162
9624143-3	1998	Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells resulted in cleavage of the death substrates PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45, but not alpha-fodrin.	Staurosporine	26-39	gelsolin	Homo sapiens	164-172
9624143-3	1998	Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells resulted in cleavage of the death substrates PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45, but not alpha-fodrin.	Staurosporine	26-39	DNA fragmentation factor subunit alpha	Homo sapiens	178-184
9624143-3	1998	Tumor necrosis factor- or staurosporine-induced apoptosis of caspase-3-deficient MCF-7 cells resulted in cleavage of the death substrates PARP, Rb, PAK2, DNA-PKcs, gelsolin, and DFF-45, but not alpha-fodrin.	Staurosporine	26-39	spectrin alpha, non-erythrocytic 1	Homo sapiens	194-206
9624143-6	1998	In addition, tumor necrosis factor- or staurosporine-induced apoptosis of MCF-7 cells stably expressing pro-caspase-3 also resulted in alpha-fodrin cleavage.	Staurosporine	39-52	caspase 3	Homo sapiens	104-117
9624143-6	1998	In addition, tumor necrosis factor- or staurosporine-induced apoptosis of MCF-7 cells stably expressing pro-caspase-3 also resulted in alpha-fodrin cleavage.	Staurosporine	39-52	spectrin alpha, non-erythrocytic 1	Homo sapiens	135-147
9633917-8	1998	Pretreatment of myocytes with staurosporine also reduced the myotrophin-induced mRNA levels of c-fos and beta-myosin heavy chain.	Staurosporine	30-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	95-100
10200498-1	1998	Treatment of HL-60 cells with staurosporine (STS) induced mitochondrial cytochrome c efflux into the cytosol, which was followed by caspase-3 activation and apoptosis.	Staurosporine	30-43	cytochrome c, somatic	Homo sapiens	72-84
9633917-7	1998	The effect of myotrophin on the stimulation of PKC activity and [3H]leucine incorporation was abolished by pretreatment with either staurosporine or H-7, two selective, pharmacological PKC inhibitors.	Staurosporine	132-145	myotrophin	Rattus norvegicus	14-24
9633917-7	1998	The effect of myotrophin on the stimulation of PKC activity and [3H]leucine incorporation was abolished by pretreatment with either staurosporine or H-7, two selective, pharmacological PKC inhibitors.	Staurosporine	132-145	protein kinase C, alpha	Rattus norvegicus	47-50
9633917-7	1998	The effect of myotrophin on the stimulation of PKC activity and [3H]leucine incorporation was abolished by pretreatment with either staurosporine or H-7, two selective, pharmacological PKC inhibitors.	Staurosporine	132-145	protein kinase C, alpha	Rattus norvegicus	185-188
9633917-8	1998	Pretreatment of myocytes with staurosporine also reduced the myotrophin-induced mRNA levels of c-fos and beta-myosin heavy chain.	Staurosporine	30-43	myotrophin	Rattus norvegicus	61-71
9633917-8	1998	Pretreatment of myocytes with staurosporine also reduced the myotrophin-induced mRNA levels of c-fos and beta-myosin heavy chain.	Staurosporine	30-43	myosin heavy chain 7	Rattus norvegicus	105-128
9531615-5	1998	Functional significance of the prolonged STAT1 signal, therefore, was explored by experimental interruption of tyrosine phosphorylation, either by premature withdrawal of the IFN-alpha or deferred addition of pharmacologically diverse antagonists: staurosporine (protein kinase inhibitor), phorbol 12-myristate 13-acetate (growth promoter), or aurintricarboxylic acid (ligand competitor).	Staurosporine	248-261	signal transducer and activator of transcription 1	Homo sapiens	41-46
9558095-5	1998	Extracellular Tat also stimulated Ser133 CREB phosphorylation in freshly isolated PBMC; this effect was completely blocked by either staurosporin, a broad-spectrum inhibitor of various protein kinases, or PD 98059, a specific inhibitor of mitogen-activated protein kinases (MAPK).	Staurosporine	133-145	tyrosine aminotransferase	Homo sapiens	14-17
9525871-9	1998	Protein kinase C inhibitors (H7, staurosporin, and chelerythrine) inhibited EGF-induced CREB phosphorylation, whereas either mitogen-activated protein kinase kinase-1 inhibitor (PD98059) or protein kinase A inhibitor (H8) showed no effect.	Staurosporine	33-45	epidermal growth factor	Homo sapiens	76-79
9525871-9	1998	Protein kinase C inhibitors (H7, staurosporin, and chelerythrine) inhibited EGF-induced CREB phosphorylation, whereas either mitogen-activated protein kinase kinase-1 inhibitor (PD98059) or protein kinase A inhibitor (H8) showed no effect.	Staurosporine	33-45	cAMP responsive element binding protein 1	Homo sapiens	88-92
9525871-10	1998	Furthermore, H7 and staurosporin but not H8 inhibited hCGalpha promoter activation by EGF.	Staurosporine	20-32	chromogranin A	Homo sapiens	54-62
9525871-10	1998	Furthermore, H7 and staurosporin but not H8 inhibited hCGalpha promoter activation by EGF.	Staurosporine	20-32	epidermal growth factor	Homo sapiens	86-89
9617483-3	1998	Heat-induced Hsp72 accumulation was also suppressed by staurosporine (a potent inhibitor of PKC and PKA) or calphostin C [(CAL) a potent inhibitor of PKC] at high concentration (10 x IC50) but not at low concentration (1 x IC50).	Staurosporine	55-68	heat shock protein family A (Hsp70) member 1A	Homo sapiens	13-18
9617483-3	1998	Heat-induced Hsp72 accumulation was also suppressed by staurosporine (a potent inhibitor of PKC and PKA) or calphostin C [(CAL) a potent inhibitor of PKC] at high concentration (10 x IC50) but not at low concentration (1 x IC50).	Staurosporine	55-68	proline rich transmembrane protein 2	Homo sapiens	92-95
9528972-8	1998	Further, in 3T3-F442A fibroblasts with endogenous GHR, GH-stimulated c-fos expression and 2-deoxyglucose uptake were reduced by the tyrosine kinase inhibitors herbimycin A, staurosporine, and P11.	Staurosporine	173-186	growth hormone receptor	Cricetulus griseus	50-53
9528997-8	1998	The receptor-independent secretagogues beta phorbol myristate acetate and forskolin dose dependently increased the secretion of GLP-1; effects inhibited by staurosporine and H8 respectively.	Staurosporine	156-169	glucagon	Canis lupus familiaris	128-133
9703866-0	1998	Treatment of human glioblastoma cells with the staurosporine derivative CGP 41251 inhibits CDC2 and CDK2 kinase activity and increases radiation sensitivity.	Staurosporine	47-60	cyclin dependent kinase 2	Homo sapiens	100-104
9703866-1	1998	CGP, 41251, a staurosporine derivative, is a potent inhibitor of protein kinase C (PKC).	Staurosporine	14-27	proline rich transmembrane protein 2	Homo sapiens	65-81
9703866-1	1998	CGP, 41251, a staurosporine derivative, is a potent inhibitor of protein kinase C (PKC).	Staurosporine	14-27	proline rich transmembrane protein 2	Homo sapiens	83-86
9604867-11	1998	The PKC inhibitors staurosporine, bisindolylmaleimide, and AMG-C16 blocked the stimulated translocation of PKC-alpha and -beta, but not that of PKC-zeta.	Staurosporine	19-32	protein kinase C, alpha	Rattus norvegicus	4-7
9604867-11	1998	The PKC inhibitors staurosporine, bisindolylmaleimide, and AMG-C16 blocked the stimulated translocation of PKC-alpha and -beta, but not that of PKC-zeta.	Staurosporine	19-32	protein kinase C, alpha	Rattus norvegicus	107-116
9660181-10	1998	Clusterin mRNA levels were strongly induced in pancreatic acinar AR4-2J cells in response to various apoptotic stimuli (i.e., cycloheximide, staurosporine, ceramide and H2O2) but not with interleukin (IL)-1, IL-4 or IL-6 or heat shock, which do not induce apoptosis in AR4-2J cells.	Staurosporine	141-154	clusterin	Rattus norvegicus	0-9
9749983-5	1998	While staurosporin and genistein inhibited both Yersinia invasion and Yersinia-triggered IL-8 secretion, wortmannin, an inhibitor of the phosphatidylinositol-3-phosphate kinase (PI3-K), blocked invasion of Y. enterocolitica into HeLa cells but did not show any effect on IL-8 secretion.	Staurosporine	6-18	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
9560443-4	1998	Cell exposure to the alpha1-adrenoceptor agonist phenylephrine (PE, 20 microM) and IGF-1 (60 ng/ml) for 72 h both induced a significant increase of cell size indicating myocyte hypertrophy, which could be separately blocked by the protein kinase C inhibitor staurosporine (20 nM) and the tyrosine kinase inhibitor genistein (15 microM).	Staurosporine	258-271	insulin-like growth factor 1	Rattus norvegicus	83-88
9560447-9	1998	A protein kinase C (PKC) activator inhibited the GIRK currents both in high and low [Na+]out, apparently mimicking agonist-induced desensitization; however, a potent serine/threonine protein kinase blocker, staurosporine, blocked only a minor part of desensitization.	Staurosporine	207-220	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	49-53
9593754-6	1998	In cells overexpressing Cdx1 or Cdx2, tumorigenicity and resistance to apoptosis induced by serum starvation, ceramide, or staurosporine were not changed compared with control cells; yet phorbol ester-stimulated cell migration was decreased by 50%.	Staurosporine	123-136	caudal type homeobox 1	Homo sapiens	24-28
9593754-6	1998	In cells overexpressing Cdx1 or Cdx2, tumorigenicity and resistance to apoptosis induced by serum starvation, ceramide, or staurosporine were not changed compared with control cells; yet phorbol ester-stimulated cell migration was decreased by 50%.	Staurosporine	123-136	caudal type homeobox 2	Homo sapiens	32-36
9582362-3	1998	Preexposure of 3T3hIR cells to staurosporine reduced insulin-induced receptor coprecipitation with PKC-alpha, -delta, and -zeta by 3-, 4-, and 10-fold, respectively, accompanied by a 1.5-fold decrease in insulin degradation and a similar increase in insulin retroendocytosis.	Staurosporine	31-44	protein kinase C, alpha	Mus musculus	99-127
9593858-5	1998	A role for PKC in ET-1-induced AA release is supported by the findings that the phorbol ester, PDBu, increased AA release by 96%, that prolonged treatment of the cells with PDBu resulted in the selective down regulation of PKCalpha and the complete inhibition of ET-1-induced AA release, and that pretreatment of the cells with staurosporine or RO 31-8220, PKC inhibitors, blocked the ET-1-induced AA release.	Staurosporine	328-341	protein kinase C alpha	Homo sapiens	11-14
9593858-5	1998	A role for PKC in ET-1-induced AA release is supported by the findings that the phorbol ester, PDBu, increased AA release by 96%, that prolonged treatment of the cells with PDBu resulted in the selective down regulation of PKCalpha and the complete inhibition of ET-1-induced AA release, and that pretreatment of the cells with staurosporine or RO 31-8220, PKC inhibitors, blocked the ET-1-induced AA release.	Staurosporine	328-341	endothelin 1	Homo sapiens	18-22
9593858-5	1998	A role for PKC in ET-1-induced AA release is supported by the findings that the phorbol ester, PDBu, increased AA release by 96%, that prolonged treatment of the cells with PDBu resulted in the selective down regulation of PKCalpha and the complete inhibition of ET-1-induced AA release, and that pretreatment of the cells with staurosporine or RO 31-8220, PKC inhibitors, blocked the ET-1-induced AA release.	Staurosporine	328-341	protein kinase C alpha	Homo sapiens	223-226
9645467-6	1998	In this study we found that the known inhibitor of protein kinases staurosporine supresses PRR in NER-deficient cells which is consistent with the view that BRCA1 and PCNA are required for PRR.	Staurosporine	67-80	BRCA1 DNA repair associated	Homo sapiens	157-162
9645467-6	1998	In this study we found that the known inhibitor of protein kinases staurosporine supresses PRR in NER-deficient cells which is consistent with the view that BRCA1 and PCNA are required for PRR.	Staurosporine	67-80	proliferating cell nuclear antigen	Homo sapiens	167-171
9572838-9	1998	However, staurosporine, which fully blocked the effects of PMA, forskolin, and clacitonin, partially decreased the effects of PTH on PTH/PTHrP receptor phosphorylation.	Staurosporine	9-22	parathyroid hormone	Rattus norvegicus	126-129
9572838-9	1998	However, staurosporine, which fully blocked the effects of PMA, forskolin, and clacitonin, partially decreased the effects of PTH on PTH/PTHrP receptor phosphorylation.	Staurosporine	9-22	parathyroid hormone	Rattus norvegicus	133-136
9572838-9	1998	However, staurosporine, which fully blocked the effects of PMA, forskolin, and clacitonin, partially decreased the effects of PTH on PTH/PTHrP receptor phosphorylation.	Staurosporine	9-22	parathyroid hormone-like hormone	Rattus norvegicus	137-142
9572838-12	1998	These data indicate that the PTH/PTHrP receptor is phosphorylated after PTH stimulation on two regions of the carboxyl-terminal tail and that agonist-dependent phosphorylation involves both staurosporine-sensitive and -insensitive kinases.	Staurosporine	190-203	parathyroid hormone	Rattus norvegicus	29-32
9572838-12	1998	These data indicate that the PTH/PTHrP receptor is phosphorylated after PTH stimulation on two regions of the carboxyl-terminal tail and that agonist-dependent phosphorylation involves both staurosporine-sensitive and -insensitive kinases.	Staurosporine	190-203	parathyroid hormone-like hormone	Rattus norvegicus	33-38
9572838-12	1998	These data indicate that the PTH/PTHrP receptor is phosphorylated after PTH stimulation on two regions of the carboxyl-terminal tail and that agonist-dependent phosphorylation involves both staurosporine-sensitive and -insensitive kinases.	Staurosporine	190-203	parathyroid hormone	Rattus norvegicus	33-36
9579573-4	1998	Staurosporine, a protein kinase inhibitor, stimulated uPA and MMP-9 secretion as measured by radial caseinolysis, zymography and Western blotting.	Staurosporine	0-13	plasminogen activator, urokinase	Mus musculus	54-57
9579573-4	1998	Staurosporine, a protein kinase inhibitor, stimulated uPA and MMP-9 secretion as measured by radial caseinolysis, zymography and Western blotting.	Staurosporine	0-13	matrix metallopeptidase 9	Mus musculus	62-67
9579573-5	1998	Genistein, a specific tyrosine kinase inhibitor, reduced the constitutive and staurosporine-induced uPA and MMP-9 secretion.	Staurosporine	78-91	plasminogen activator, urokinase	Mus musculus	100-103
9579573-5	1998	Genistein, a specific tyrosine kinase inhibitor, reduced the constitutive and staurosporine-induced uPA and MMP-9 secretion.	Staurosporine	78-91	matrix metallopeptidase 9	Mus musculus	108-113
9579573-9	1998	Our results suggest that constitutive and staurosporine-induced uPA and MMP-9 secretion by LM3 murine mammary tumor cells is controlled by an endogenous tyrosine kinase pathway and probably involves protein phosphatases.	Staurosporine	42-55	plasminogen activator, urokinase	Mus musculus	64-67
9579573-9	1998	Our results suggest that constitutive and staurosporine-induced uPA and MMP-9 secretion by LM3 murine mammary tumor cells is controlled by an endogenous tyrosine kinase pathway and probably involves protein phosphatases.	Staurosporine	42-55	matrix metallopeptidase 9	Mus musculus	72-77
9612301-4	1998	These effects of ET-1 on K+ current were markedly reduced by inhibitors of protein kinase C (staurosporine and GF 109203X) and phospholipase C (U-73122) or under Ca(2+)-free conditions and were mimicked by activators of protein kinase C (phorbol 12-myristate 13-actetate and 1,2-dioctanoyl-sn-glycerol).	Staurosporine	93-106	endothelin 1	Rattus norvegicus	17-21
9558373-8	1998	In the presence of LLnL, stable phosphorylation of STAT5 and betac was abrogated if the tyrosine kinase inhibitor, staurosporine, was added.	Staurosporine	115-128	signal transducer and activator of transcription 5A	Mus musculus	51-56
9558373-9	1998	The effect of staurosporine on STAT5 phosphorylation could be overcome if the phosphatase inhibitor, vanadate, was also added, suggesting phosphorylated STAT5 could be stabilized by phosphatase, but not by proteasome inhibition per se.	Staurosporine	14-27	signal transducer and activator of transcription 5A	Mus musculus	31-36
9797704-6	1998	2-CdA, CGP 52411, tyrphostin A48, staurosporine and NDGA were active as sensitisers against ara-C in HL-60 cells, CGP 52411 and tyrphostin A48 also in HL-60/ara-C cells, and 2-CdA, staurosporine and NDGA also in U937 cells.	Staurosporine	181-194	cytidine deaminase	Homo sapiens	2-5
9581683-7	1998	In experiments with kinase inhibitors, serine/threonine kinase inhibitor K252a blocked IL-1beta- and IL-6-induced inhibitions of glycogen deposition, as well as glycogen synthase activity, whereas another kinase inhibitor staurosporine blocked only IL-6-induced inhibition.	Staurosporine	222-235	interleukin 6	Rattus norvegicus	101-105
9639100-4	1998	Other compounds such as basic fibroblast growth factor and staurosporine each increased MMP-9 expression individually and potentiated the effects of the two cytokines.	Staurosporine	59-72	matrix metallopeptidase 9	Rattus norvegicus	88-93
9605926-7	1998	Inhibition of PKC by staurosporine augmented Ang II-stimulated AT1-R phosphorylation, suggesting a negative regulatory role of PKC on the putative G protein-coupled receptor kinase(s) that mediates the majority of AT1-R phosphorylation.	Staurosporine	21-34	ANG	Bos taurus	45-48
9605926-7	1998	Inhibition of PKC by staurosporine augmented Ang II-stimulated AT1-R phosphorylation, suggesting a negative regulatory role of PKC on the putative G protein-coupled receptor kinase(s) that mediates the majority of AT1-R phosphorylation.	Staurosporine	21-34	angiotensin II receptor type 1	Bos taurus	63-66
9605926-7	1998	Inhibition of PKC by staurosporine augmented Ang II-stimulated AT1-R phosphorylation, suggesting a negative regulatory role of PKC on the putative G protein-coupled receptor kinase(s) that mediates the majority of AT1-R phosphorylation.	Staurosporine	21-34	angiotensin II receptor type 1	Bos taurus	214-217
9618801-7	1998	Inhibition of PKC by H7 or staurosporin (PKC inhibitors) or down-regulation by long-term treatment with 12-O-tetradecanoylphorbol-13-acetate enchanced ER binding capacity in a dose-dependent manner.	Staurosporine	27-39	estrogen receptor 1 (alpha)	Mus musculus	151-153
9545236-2	1998	In this paper we show that Mst1 is specifically cleaved by a caspase 3-like activity during apoptosis induced by either cross-linking CD95/Fas or by staurosporine treatment.	Staurosporine	149-162	macrophage stimulating 1	Homo sapiens	27-31
10200477-4	1998	Inhibition of RNase L activity, by transfection with a dominant negative mutant, blocked staurosporine-induced apoptosis of NIH3T3 cells and SV40-transformed BALB/c cells.	Staurosporine	89-102	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)	Mus musculus	14-21
9535217-10	1998	The PMA-induced increase in HSF1 phosphorylation in HSP-70 cDNA-transfected cells was blocked by pretreatment with staurosporine, a PKC inhibitor.	Staurosporine	115-128	heat shock transcription factor 1	Homo sapiens	28-32
9535217-10	1998	The PMA-induced increase in HSF1 phosphorylation in HSP-70 cDNA-transfected cells was blocked by pretreatment with staurosporine, a PKC inhibitor.	Staurosporine	115-128	heat shock protein family A (Hsp70) member 4	Homo sapiens	52-58
10200498-1	1998	Treatment of HL-60 cells with staurosporine (STS) induced mitochondrial cytochrome c efflux into the cytosol, which was followed by caspase-3 activation and apoptosis.	Staurosporine	30-43	caspase 3	Homo sapiens	132-141
10200498-1	1998	Treatment of HL-60 cells with staurosporine (STS) induced mitochondrial cytochrome c efflux into the cytosol, which was followed by caspase-3 activation and apoptosis.	Staurosporine	45-48	cytochrome c, somatic	Homo sapiens	72-84
10200498-1	1998	Treatment of HL-60 cells with staurosporine (STS) induced mitochondrial cytochrome c efflux into the cytosol, which was followed by caspase-3 activation and apoptosis.	Staurosporine	45-48	caspase 3	Homo sapiens	132-141
9918749-0	1998	Chronic hypoxia increases staurosporine sensitivity of pulmonary artery smooth muscle to endothelin-1.	Staurosporine	26-39	endothelin 1	Rattus norvegicus	89-101
9918749-5	1998	Staurosporine, a PKC inhibitor, decreased ET-1 sensitivity of PA from 0, 14, and 28 days air-exposed rats by four- to nine-fold without affecting Emax.	Staurosporine	0-13	endothelin 1	Rattus norvegicus	42-46
9918749-6	1998	However, staurosporine markedly decreased hypoxic PA sensitivity to ET-1 (change in EC50: 14 days, 1700-fold; 28 days, 55-fold vs. hypoxic controls) and decreased Emax (% decrease from hypoxic control: 14 days, 38+/-6%; 28 days, 59+/-7%).	Staurosporine	9-22	endothelin 1	Rattus norvegicus	68-72
9507032-4	1998	CSF-1 treatment protected cells expressing the CSF1R/IR from staurosporine-induced apoptosis.	Staurosporine	61-74	colony stimulating factor 1	Homo sapiens	0-5
9566590-8	1998	It appears that both translational and posttranslational events contributed to the increased AP-1 DNA binding since cyclohexamide (a protein synthesis inhibitor), genistein (tyrosine kinase inhibitor) and staurosporine (PKC inhibitor) each partially blocked the AP-1 activation.	Staurosporine	205-218	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-97
9507032-4	1998	CSF-1 treatment protected cells expressing the CSF1R/IR from staurosporine-induced apoptosis.	Staurosporine	61-74	colony stimulating factor 1 receptor	Homo sapiens	47-55
9507032-10	1998	Surprisingly, the CSF1R/IRDelta960 was as effective as the CSF1R/IR in mediating CSF-1 protection of cells from staurosporine-induced apoptosis.	Staurosporine	112-125	colony stimulating factor 1 receptor	Homo sapiens	18-34
9507032-10	1998	Surprisingly, the CSF1R/IRDelta960 was as effective as the CSF1R/IR in mediating CSF-1 protection of cells from staurosporine-induced apoptosis.	Staurosporine	112-125	colony stimulating factor 1 receptor	Homo sapiens	18-26
9507032-10	1998	Surprisingly, the CSF1R/IRDelta960 was as effective as the CSF1R/IR in mediating CSF-1 protection of cells from staurosporine-induced apoptosis.	Staurosporine	112-125	colony stimulating factor 1	Homo sapiens	81-86
9531253-8	1998	In addition, inhibition of protein kinase C by staurosporine (10 nmol/L) and blockade of L-type Ca2+ channels by diltiazem (1 micromol/L) significantly decreased the sustained phase of ADM-induced increase in developed tension.	Staurosporine	47-60	adrenomedullin	Rattus norvegicus	185-188
9586958-3	1998	The protein kinase inhibitor staurosporine and the temperature sensitive (ts) p34cdc2 mutant reduced induction by the alkylating agent methylmethane sulfonate (MMS) of the rodent gadd45 and gadd153 genes.	Staurosporine	29-42	growth arrest and DNA damage inducible alpha	Homo sapiens	179-185
9734941-5	1998	The part played by protein kinase C (PKC) signalling was examined by down-regulation with phorbol ester and with the inhibitors Goe 6976 and staurosporine.	Staurosporine	141-154	protein kinase C alpha	Homo sapiens	37-40
9493910-6	1998	Taxol-induced phosphorylation of vimentin was largely abolished in cells pretreated with staurosporine and bisindolymaleimide but was unaffected by H-89, KT-5926, SB203580, genistein, and olomoucine.	Staurosporine	89-102	vimentin	Rattus norvegicus	33-41
9586958-3	1998	The protein kinase inhibitor staurosporine and the temperature sensitive (ts) p34cdc2 mutant reduced induction by the alkylating agent methylmethane sulfonate (MMS) of the rodent gadd45 and gadd153 genes.	Staurosporine	29-42	DNA damage inducible transcript 3	Homo sapiens	190-197
9540824-10	1998	The activation was inhibited also by pretreatment with staurosporine and was sustained by pretreatment with calyculin A, suggesting that the protein kinase activity is regulated by protein phosphorylation/dephosphorylation.	Staurosporine	55-68	mitogen-activated protein kinase kinase kinase NPK1	Nicotiana tabacum	141-155
9525737-10	1998	Bcr - Abl cells to staurosporine.	Staurosporine	19-32	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	0-9
9515027-0	1998	Staurosporine-induced apoptosis in cardiomyocytes: A potential role of caspase-3.	Staurosporine	0-13	caspase 3	Homo sapiens	71-80
9515027-12	1998	Moreover, the appearance of the 17-kD subunit of active caspase-3 in staurosporine-treated myocytes was demonstrated by immunocytochemical analysis.	Staurosporine	69-82	caspase 3	Homo sapiens	56-65
9515027-13	1998	In contrast, staurosporine induced a rapid and transient inhibition of SAPK/JNK in myocytes.	Staurosporine	13-26	mitogen-activated protein kinase 8	Homo sapiens	76-79
9515027-15	1998	Our results suggest that staurosporine-induced cardiac myocyte apoptosis involves activation of caspases, mainly caspase-3, but not activation of the SAPK signaling pathway.	Staurosporine	25-38	caspase 3	Homo sapiens	113-122
9511729-10	1998	The nonspecific protein kinase inhibitor staurosporine at a concentration known to arrest lymphocytes in G1 but not to interfere with the induction of cyclin D3 (20 nM) prevented pRb phosphorylation.	Staurosporine	41-54	retinol binding protein 4	Homo sapiens	179-182
9485038-5	1998	In particular, IGF-II-deficient betaTCs are more sensitive to apoptotic stimuli, such as serum deprivation and staurosporine, and to chemotherapeutic agents, such as daunomycin, etoposide, or vincristine.	Staurosporine	111-124	insulin-like growth factor 2	Mus musculus	15-21
9487139-8	1998	OSBP was phosphorylated in vitro by the Golgi enriched fraction of CHO-K1 cells or rat liver by a staurosporine- and BFA-insensitive kinase.	Staurosporine	98-111	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	0-4
9461560-5	1998	In support of a role for Rb in staurosporine-induced G1 arrest, rat embryonic fibroblasts stably overexpressing cyclin D1/Cdk4(R24C) exhibited approximately a 50% reduced G1 arrest response to staurosporine.	Staurosporine	31-44	cyclin D1	Rattus norvegicus	112-121
9461560-5	1998	In support of a role for Rb in staurosporine-induced G1 arrest, rat embryonic fibroblasts stably overexpressing cyclin D1/Cdk4(R24C) exhibited approximately a 50% reduced G1 arrest response to staurosporine.	Staurosporine	31-44	cyclin-dependent kinase 4	Rattus norvegicus	122-126
9461560-5	1998	In support of a role for Rb in staurosporine-induced G1 arrest, rat embryonic fibroblasts stably overexpressing cyclin D1/Cdk4(R24C) exhibited approximately a 50% reduced G1 arrest response to staurosporine.	Staurosporine	193-206	cyclin D1	Rattus norvegicus	112-121
9487139-3	1998	Phosphorylation of rabbit OSBP stably overexpressed in CHO-K1 cells was altered by staurosporine and okadaic acid, while other protein kinase activators and inhibitors such as TPA, sphingosine and bis-indolylmaleimide were without affect.	Staurosporine	83-96	oxysterol-binding protein 1	Oryctolagus cuniculus	26-30
9481487-4	1998	Treatment of labelled PMN with low concentrations of staurosporine (12.5 and 50 nM) which prime respiratory burst had no significant effect on basal amounts of tritiated PA and DG, but potentiated fMLP-mediated formation of [3H]PA and phosphatidylethanol (PEt) pointing to a priming of PLD activity.	Staurosporine	53-66	formyl peptide receptor 1	Homo sapiens	197-201
9481487-4	1998	Treatment of labelled PMN with low concentrations of staurosporine (12.5 and 50 nM) which prime respiratory burst had no significant effect on basal amounts of tritiated PA and DG, but potentiated fMLP-mediated formation of [3H]PA and phosphatidylethanol (PEt) pointing to a priming of PLD activity.	Staurosporine	53-66	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	286-289
9481487-6	1998	Low staurosporine concentrations (6.25-25 nM) markedly potentiated PA mass formation induced by fMLP and positive correlation (R = 0.95) was found between enhanced superoxide formation and generation of PA but not DG.	Staurosporine	4-17	formyl peptide receptor 1	Homo sapiens	96-100
9481487-9	1998	These data indicate that priming of fMLP-mediated PMN respiratory burst by staurosporine correlates with PA formation.	Staurosporine	75-88	formyl peptide receptor 1	Homo sapiens	36-40
9512898-3	1998	Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine.	Staurosporine	106-119	interleukin 6	Homo sapiens	0-13
9512898-3	1998	Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine.	Staurosporine	106-119	interleukin 6	Homo sapiens	15-19
9512898-3	1998	Interleukin 6 (IL-6) and IL-8 production in response to PMA were markedly diminished by the PKC inhibitor staurosporine.	Staurosporine	106-119	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
9533433-8	1998	The increased production of NO from rIFN-gamma plus YS-Tang-stimulated cells was decreased by the treatment with staurosporin.	Staurosporine	113-125	interferon gamma	Rattus norvegicus	36-46
9486765-7	1998	The caspase inhibitor zVAD-fmk and the anti-apoptotic gene product Bcl-2 prevented the sustained [Ca2+]i increase and ROS accumulation induced by staurosporine indicating that caspases act very early in the apoptotic process.	Staurosporine	146-159	BCL2, apoptosis regulator	Rattus norvegicus	67-72
9660918-5	1998	When overexpressed in mammalian cells, BI-1 suppressed apoptosis included by Bax, etoposide, staurosporine, and growth factor deprivation, but not by Fas (CD95).	Staurosporine	93-106	transmembrane BAX inhibitor motif containing 6	Homo sapiens	39-43
11324523-4	1998	All of these ET-1-induced cardiomyocyte hypertrophic responses were completely blocked by pretreatment with staurosporine (2 nmol/L), a protein kinase C inhibitor, and stimulated by 4-phorbol, 12-myristate, 13-acetate (PMA) (10(-8)-10(-6) mol/L), a protein kinase C activator, in a dose-dependent manner.	Staurosporine	108-121	endothelin 1	Rattus norvegicus	13-17
9490004-4	1998	IGF-1-stimulated protein synthesis was also significantly inhibited by PD-098059, staurosporine, and rapamycin, but not by wortmannin, in cardiac myocytes.	Staurosporine	82-95	insulin-like growth factor 1	Rattus norvegicus	0-5
9427739-4	1998	Here, we report that cytochrome c release from mitochondria is an early event in the apoptotic process induced by UVB irradiation or staurosporine treatment in CEM or HeLa cells, preceding or at the time of DEVD-specific caspase activation and substrate cleavage.	Staurosporine	133-146	cytochrome c, somatic	Homo sapiens	21-33
9554589-0	1998	Expression of Bcl-2 in human epithelial tumor (HeLa) cells enhances clonogenic survival following exposure to 5-fluoro-2"-deoxyuridine or staurosporine, but not following exposure to etoposide or doxorubicin.	Staurosporine	138-151	BCL2 apoptosis regulator	Homo sapiens	14-19
9554589-8	1998	RESULTS: Despite profound inhibition to loss of plasma membrane integrity for all agents tested, Bcl-2 was only able to significantly increase clonogenic survival following exposure to 5-fluoro-2"-deoxyuridine and staurosporine, but not following exposure to etoposide or doxorubicin.	Staurosporine	214-227	BCL2 apoptosis regulator	Homo sapiens	97-102
10328851-9	1998	Staurosporine, an inhibitor of protein kinase C, inhibited actin assembly and platelet aggregation induced by thrombin or PMA, but did not inhibit the incorporation of 56 kDa, 80 kDa and 85 kDa into the cytoskeletal fraction induced by thrombin.	Staurosporine	0-13	coagulation factor II, thrombin	Sus scrofa	110-118
9533826-6	1998	Phorbol esters (PMA), activators of PKC, also raised the immunoreactive levels of ET-1 and Big ET-1 while, staurosporine, a PKC inhibitor (20 nm), decreased ET-1 levels in TNF-alpha-stimulated cells.	Staurosporine	107-120	endothelin 1	Homo sapiens	82-99
9533826-6	1998	Phorbol esters (PMA), activators of PKC, also raised the immunoreactive levels of ET-1 and Big ET-1 while, staurosporine, a PKC inhibitor (20 nm), decreased ET-1 levels in TNF-alpha-stimulated cells.	Staurosporine	107-120	endothelin 1	Homo sapiens	82-86
9533826-6	1998	Phorbol esters (PMA), activators of PKC, also raised the immunoreactive levels of ET-1 and Big ET-1 while, staurosporine, a PKC inhibitor (20 nm), decreased ET-1 levels in TNF-alpha-stimulated cells.	Staurosporine	107-120	tumor necrosis factor	Homo sapiens	172-181
9453318-11	1998	1,2-Dioctanoyl-glycerol, a PKC activator, mimicked the high-glucose effect on IL-1beta-induced NO release, while staurosporine, a PKC inhibitor, reversed it.	Staurosporine	113-126	interleukin 1 beta	Homo sapiens	78-86
9528972-9	1998	Herbimycin A and staurosporine inhibit JAK2 and tyrosyl phosphorylation of all proteins stimulated by GH, whereas P11 inhibits the GH-dependent tyrosyl phosphorylation of only some proteins, including extracellular signal regulated kinases ERK1 and -2, but not JAK2.	Staurosporine	17-30	tyrosine-protein kinase JAK2	Cricetulus griseus	39-43
9486128-6	1998	Treatment of cells with staurosporine, a PKC inhibitor, fully prevented heterologous desensitization, whereas thrombin-induced homologous desensitization persisted.	Staurosporine	24-37	protein kinase C beta	Homo sapiens	41-44
9481487-1	1998	Staurosporine, a microbial alkaloid known as a potent though non specific PKC inhibitor, enhances the production of superoxide anion (respiratory burst) of human polymorphonuclear leukocytes (PMN) stimulated by chemoattractants such as f-Met-Leu-Phe (fMLP).	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	251-255
9481487-2	1998	To gain insights into the mechanisms of this priming, we analysed staurosporine effects on formation of second messengers issued from phospholipase D (PLD), i.e., phosphatidic acid (PA) and its dephosphorylated form, diglycerides (DG).	Staurosporine	66-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	134-149
9481487-2	1998	To gain insights into the mechanisms of this priming, we analysed staurosporine effects on formation of second messengers issued from phospholipase D (PLD), i.e., phosphatidic acid (PA) and its dephosphorylated form, diglycerides (DG).	Staurosporine	66-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	151-154
9543699-4	1998	H-7, phloretin, staurosporine as well as GF 109203X are selective enzyme inhibitors of protein kinase C (PKC), down-regulating IFN-gamma induced MHC class II expression and cytokine production.	Staurosporine	16-29	interferon gamma	Homo sapiens	127-136
9426300-2	1998	Previous work has suggested the concerted action of protein kinase C (PKC) and a staurosporine-insensitive receptor kinase in homologous phosphorylation of the cholecystokinin (CCK) receptor in freshly isolated rat pancreatic acinar cells [Gates, Ulrich, Miller (1993) Am J Physiol 264:G840-G847].	Staurosporine	81-94	cholecystokinin	Rattus norvegicus	177-180
9484835-12	1998	Of the tested inhibitors, only staurosporine, a known inhibitor of protein kinase C (PKC) and various other kinases, inhibited both p53 activation and accumulation, whereas specific PKC inhibitors, tyrosine kinase inhibitors and a serine/threonine kinase inhibitor did not.	Staurosporine	31-44	tumor protein p53	Homo sapiens	132-135
9484835-14	1998	Kinetic studies showed that staurosporine-mediated inhibition of p53 function is an early event in cell damage response.	Staurosporine	28-41	tumor protein p53	Homo sapiens	65-68
9484835-15	1998	Thus dual, kinetically different events, de novo protein synthesis and staurosporine-inhibited protein phosphorylation are required for p53 activation and accumulation in all phases of the cell cycle.	Staurosporine	71-84	tumor protein p53	Homo sapiens	136-139
9442092-7	1998	Bile acid-mediated induction of COX-2 was blocked by inhibitors of PKC activity, including calphostin C and staurosporine.	Staurosporine	108-121	prostaglandin-endoperoxide synthase 2	Homo sapiens	32-37
9442097-6	1998	Moreover, hSERT phosphorylation induced by beta-phorbol 12-myristate 13-acetate is abolished selectively by the PKC inhibitors staurosporine and bisindolylmaleimide I, whereas hSERT phosphorylation induced by phosphatase inhibitors is insensitive to these agents at comparable concentrations.	Staurosporine	127-140	solute carrier family 6 member 4	Homo sapiens	10-15
9515165-4	1998	We show here that the anti-CD3-stimulated elevation in PDE-4 activity in murine thymocytes is dependent on protein tyrosine kinase and protein kinase C (PKC)-mediated signals as the TCR-coupled increase in PDE-4 activity can be abrogated by both the tyrosine kinase inhibitor, genistein, and the PKC selective inhibitors chelerythrine and staurosporine.	Staurosporine	339-352	CD3 antigen, epsilon polypeptide	Mus musculus	27-30
9487139-10	1998	Furthermore, dephosphorylation of OSBP by staurosporine did not affect 25-hydroxycholesterol-mediated localization to the Golgi apparatus.	Staurosporine	42-55	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	34-38
9519815-2	1998	The purpose of this study was to elucidate the role of ICE family proteases in apoptosis of mouse cells derived from the terminal proximal tubule (S3) treated with cisplatin, an anti-tumor drug, or staurosporine, a protein kinase C inhibitor.	Staurosporine	198-211	caspase 1	Mus musculus	55-58
9422513-8	1998	The ICAD transformants were also resistant to staurosporine-induced DNA degradation, although staurosporine still killed the cells by activating caspase.	Staurosporine	46-59	DNA fragmentation factor subunit alpha	Homo sapiens	4-8
27416533-5	1998	PKC inhibitors staurosporine and H-7, as well as PTK inhibitors herbimycin A and genistein suppressed MCP-1/JE expression (mRNA and protein) in a dose dependent manner.	Staurosporine	15-28	chemokine (C-C motif) ligand 2	Mus musculus	102-107
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Staurosporine	79-92	fibronectin 1	Mus musculus	186-188
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Staurosporine	79-92	fibronectin 1	Mus musculus	193-195
11061591-6	1998	We found that treatment of resident PMphi with the protein kinase C inhibitor, staurosporine, and the activator, phorbol myristate acetate (PMA), resulted in marked modulation of either FN- or FN/CSF-1-induced cytokine release.	Staurosporine	79-92	colony stimulating factor 1 (macrophage)	Mus musculus	196-201
16793699-5	1998	Protein tyrose phosphatase (PTP) induced by Cvx was not blocked when platelets were stimulated in the presence of indomethacin, apyrase, EDTA or RGDS peptide, but inhibited by staurosporine and genistein.	Staurosporine	176-189	protein tyrosine phosphatase receptor type U	Homo sapiens	0-26
16793699-5	1998	Protein tyrose phosphatase (PTP) induced by Cvx was not blocked when platelets were stimulated in the presence of indomethacin, apyrase, EDTA or RGDS peptide, but inhibited by staurosporine and genistein.	Staurosporine	176-189	protein tyrosine phosphatase receptor type U	Homo sapiens	28-31
9460707-3	1998	Protein level of Bcl-2 was decreased by pretreatment with diBu-cAMP or staurosporine, and, on the contrary, the level was increased by pretreatment with PMA.	Staurosporine	71-84	BCL2 apoptosis regulator	Homo sapiens	17-22
9458327-3	1998	CB elevation induced by LPS alone or LPS followed by IFN- was blocked by protein kinase C (PKC) inhibitors staurosporine, H-7, phloretin and bisindolylmaleimide, and by cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89 and cAMP-dependent protein kinase (PKA) inhibitor.	Staurosporine	107-120	cathepsin B	Homo sapiens	0-2
9458327-3	1998	CB elevation induced by LPS alone or LPS followed by IFN- was blocked by protein kinase C (PKC) inhibitors staurosporine, H-7, phloretin and bisindolylmaleimide, and by cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89 and cAMP-dependent protein kinase (PKA) inhibitor.	Staurosporine	107-120	interferon alpha 1	Homo sapiens	53-57
9769475-3	1998	Treatment of cells with PKC inhibitors (staurosporine, bisindolylmaleimide, or G?6976) resulted in morphological alterations and reorganization of actin filaments similar to retinoic-acid-treated cells.	Staurosporine	40-53	protein kinase C alpha	Homo sapiens	24-27
9459177-4	1997	In stable Bcl-2 transfectants, G-Rh2 also induced DNA fragmentation, while staurosporine-induced DNA fragmentation was totally blocked.	Staurosporine	75-88	BCL2 apoptosis regulator	Homo sapiens	10-15
9438871-0	1997	Structures of staurosporine bound to CDK2 and cAPK--new tools for structure-based design of protein kinase inhibitors.	Staurosporine	14-27	cyclin dependent kinase 2	Homo sapiens	37-41
9438871-2	1997	The recently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor-kinase interactions and inhibitor selectivity.	Staurosporine	104-117	cyclin dependent kinase 2	Homo sapiens	68-72
9398251-12	1997	Since the novel form of clusterin is also expressed in cells exposed to TGFbeta, colchicine, staurosporine, and azide, it may result from toxin-induced disruption of processes of normal cellular protein production.	Staurosporine	93-106	clusterin	Mus musculus	24-33
9398251-12	1997	Since the novel form of clusterin is also expressed in cells exposed to TGFbeta, colchicine, staurosporine, and azide, it may result from toxin-induced disruption of processes of normal cellular protein production.	Staurosporine	93-106	transforming growth factor, beta 1	Mus musculus	72-79
9457649-11	1997	The ET-1-induced inhibition of JCl was prevented by protein kinase C inhibitors (staurosporine or GF 109203) and was reproduced by diacylglycerol analogues (OAG and DiC8).	Staurosporine	81-94	endothelin 1	Mus musculus	4-8
9464633-2	1997	Treatment of cells with Ser/Thr protein kinase inhibitors such as staurosporine, H-7, H-8 and HA-1004, induced neurite formation without GDNF.	Staurosporine	66-79	glial cell derived neurotrophic factor	Homo sapiens	137-141
9435598-7	1997	Cromakalim dilation was attenuated by ET-1 and partially restored by the protein kinase C (PKC) inhibitor staurosporine (12 +/- 1 and 28 +/- 1 vs. 2 +/- 1 and 21 +/- 3 vs. 9 +/- 1 and 29 +/- 2% for 10(-8) and 10(-6) M cromakalim, cromakalim with ET-1, and cromakalim with ET-1 + staurosporine, respectively).	Staurosporine	106-119	endothelin 1	Homo sapiens	246-250
9435598-7	1997	Cromakalim dilation was attenuated by ET-1 and partially restored by the protein kinase C (PKC) inhibitor staurosporine (12 +/- 1 and 28 +/- 1 vs. 2 +/- 1 and 21 +/- 3 vs. 9 +/- 1 and 29 +/- 2% for 10(-8) and 10(-6) M cromakalim, cromakalim with ET-1, and cromakalim with ET-1 + staurosporine, respectively).	Staurosporine	106-119	endothelin 1	Homo sapiens	246-250
9400371-4	1997	H-89, dexamethasone, herbimycin, genistein, staurosporine, or pyrrolidine dithiocarbamate (PDTC) attenuated the iNOS induction by LPS.	Staurosporine	44-57	nitric oxide synthase 2	Rattus norvegicus	112-116
9371700-5	1997	In separate experiments using intact cells, we show that the protein phosphatase inhibitor okadaic acid mimics the action of the physiological agonist thrombin, in that it induces annexin V to bind to membranes and that the addition of the protein kinase inhibitor staurosporine inhibits A23187-induced relocation of annexin V.	Staurosporine	265-278	coagulation factor II, thrombin	Homo sapiens	151-159
9371709-8	1997	To investigate whether a similar signalling pathway was involved in both systems, platelets and adipose cells were exposed to staurosporin and wortmannin, two inhibitors of GLUT4 translocation in adipose cells.	Staurosporine	126-138	solute carrier family 2 member 4	Homo sapiens	173-178
9371709-9	1997	Thrombin stimulation of glucose transport activity in platelets was more sensitive to staurosporin inhibition than was insulin-stimulated transport activity in adipose cells, but it was totally insensitive to wortmannin.	Staurosporine	86-98	coagulation factor II, thrombin	Homo sapiens	0-8
9361188-8	1997	PKC inhibitors, calphostin C (10 nM), and staurosporine (5 nM), inhibited strain-induced PKC activation and keratinocyte proliferation, but did not block the effects of strain on cellular morphology or alignment.	Staurosporine	42-55	protein kinase C alpha	Homo sapiens	89-92
9369952-6	1997	A PKC inhibitor, staurosporine (5 microM) likewise inhibited the BK-induced increase in endothelial cell permeability to albumin.	Staurosporine	17-30	kininogen 1	Bos taurus	65-67
9487993-8	1997	In primary cultures of normal adrenal cells, a protein kinase C inhibitor, staurosporine, reduced ADM mRNA accumulation in a dose- and time-dependent fashion (P &lt; 0.01), whereas it simultaneously increased the expression of human cholesterol side-chain cleavage enzyme (P450 scc) gene (a key gene in steroidogenesis).	Staurosporine	75-88	adrenomedullin	Homo sapiens	98-101
9487993-8	1997	In primary cultures of normal adrenal cells, a protein kinase C inhibitor, staurosporine, reduced ADM mRNA accumulation in a dose- and time-dependent fashion (P &lt; 0.01), whereas it simultaneously increased the expression of human cholesterol side-chain cleavage enzyme (P450 scc) gene (a key gene in steroidogenesis).	Staurosporine	75-88	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	233-281
9487993-9	1997	In cultured Cushing"s adenoma cells, adrenocorticotropin, dibutyryl cAMP ((Bu)2cAMP) and staurosporine inhibited the accumulation of ADM mRNA by 40, 50 and 70% respectively (P &lt; 0.05), whereas the protein kinase C activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), increased it by 50% (P &lt; 0.05).	Staurosporine	89-102	adrenomedullin	Homo sapiens	133-136
9396780-7	1997	Western analysis of Bcl-2 protein obtained from overexpressing cells treated with bryostatin 1, staurosporine, or UCN-01 revealed the appearance of a slowly migrating species and a general broadening of the protein band, effects that were insensitive to the protein synthesis inhibitor cycloheximide.	Staurosporine	96-109	BCL2 apoptosis regulator	Homo sapiens	20-25
9433481-10	1997	PAF-induced PKC activity was blocked by pretreatment with either staurosporine (50 nM) or CV3988 (1 microM).	Staurosporine	65-78	PCNA clamp associated factor	Homo sapiens	0-3
9393856-5	1997	In addition, Bcl-xL-expressing cells adapt to growth factor withdrawal or staurosporine treatment by maintaining a decreased mitochondrial membrane potential.	Staurosporine	74-87	BCL2 like 1	Homo sapiens	13-19
9398059-1	1997	The staurosporine analogues CGP 41251, UCN-01 and Ro 31-8220 are specific inhibitors of protein kinase C (PKC).	Staurosporine	4-17	protein kinase C epsilon	Homo sapiens	106-109
9417875-6	1997	Treatment with the protein kinase inhibitor staurosporine, which induces a cell cycle arrest in early G1 phase, strongly reduced cyclin D1 phosphorylation.	Staurosporine	44-57	cyclin D1	Homo sapiens	129-138
9570383-3	1997	Furthermore, tamoxifen and staurosporine, both PKC inhibitors, also inhibited T98G cell invasion, suggesting that PKC may be the cellular target for hypericin-inhibited glioma cell migration.	Staurosporine	27-40	proline rich transmembrane protein 2	Homo sapiens	47-50
9570383-3	1997	Furthermore, tamoxifen and staurosporine, both PKC inhibitors, also inhibited T98G cell invasion, suggesting that PKC may be the cellular target for hypericin-inhibited glioma cell migration.	Staurosporine	27-40	proline rich transmembrane protein 2	Homo sapiens	114-117
9368003-8	1997	In addition, PRK2 is cleaved rapidly during Fas- and staurosporine-induced apoptosis in vivo by caspase-3 or a closely related caspase.	Staurosporine	53-66	protein kinase N2	Homo sapiens	13-17
9368003-8	1997	In addition, PRK2 is cleaved rapidly during Fas- and staurosporine-induced apoptosis in vivo by caspase-3 or a closely related caspase.	Staurosporine	53-66	caspase 3	Homo sapiens	96-105
9439810-6	1997	The effect of TGF-beta 1 on the increase of LIF-mRNA levels was suppressed by either staurosporine or H-7 suggesting the role of PKC or PKC-like protein kinase activity in the induction of LIF-mRNA.	Staurosporine	85-98	transforming growth factor, beta 1	Rattus norvegicus	14-24
9439810-6	1997	The effect of TGF-beta 1 on the increase of LIF-mRNA levels was suppressed by either staurosporine or H-7 suggesting the role of PKC or PKC-like protein kinase activity in the induction of LIF-mRNA.	Staurosporine	85-98	LIF, interleukin 6 family cytokine	Rattus norvegicus	44-47
9439810-6	1997	The effect of TGF-beta 1 on the increase of LIF-mRNA levels was suppressed by either staurosporine or H-7 suggesting the role of PKC or PKC-like protein kinase activity in the induction of LIF-mRNA.	Staurosporine	85-98	LIF, interleukin 6 family cytokine	Rattus norvegicus	189-192
9361003-4	1997	Here we report that the DRPLA protein is cleaved at a site near the N terminus during apoptosis induced by VP-16, staurosporine, or glucocorticoid.	Staurosporine	114-127	atrophin 1	Homo sapiens	24-29
9406872-4	1997	In addition, staurosporine 1 microM, a PK inhibitor, suppressed both BK-induced excitation and facilitation of the heat response of testicular polymodal receptors without influencing on-going activities and the heat response itself.	Staurosporine	13-26	kininogen 1	Canis lupus familiaris	69-71
9427323-1	1997	Activation of PKC with 12-tetra-decanoylphorbol-13-acetate (TPA) or inhibition with staurosporine or calphostin C down-regulated GnRH mRNA levels.	Staurosporine	84-97	gonadotropin releasing hormone 1	Mus musculus	129-133
9374665-4	1997	Treatments with forskolin, phorbol 12-myristate 13-acetate, staurosporine, and genistein also induced cell shape change and decreased F-actin staining and ET-1 mRNA levels.	Staurosporine	60-73	endothelin 1	Bos taurus	155-159
9374830-6	1997	The PTH-induced inhibition of the accumulation of PAH was blocked by a protein kinase C inhibitor staurosporine.	Staurosporine	98-111	parathyroid hormone	Homo sapiens	4-7
9427515-0	1997	Regions outside of the Bcl-2 homology domains, BH1 and BH2 protect a dopaminergic neuronal cell line from staurosporine-induced cell death.	Staurosporine	106-119	B cell leukemia/lymphoma 2	Mus musculus	23-28
9427515-0	1997	Regions outside of the Bcl-2 homology domains, BH1 and BH2 protect a dopaminergic neuronal cell line from staurosporine-induced cell death.	Staurosporine	106-119	immunoglobulin kappa variable 1-131	Mus musculus	55-58
9427515-5	1997	Overexpression of Bcl-2 rescued cells from staurosporine-induced but not trifluoperazine-induced apoptotic cell death.	Staurosporine	43-56	B cell leukemia/lymphoma 2	Mus musculus	18-23
9427515-6	1997	Cell death induced by the specific PKC inhibitor, calphostin C was also significantly attenuated in MN9D/Bcl-2 cells indicating that a PKC pathway represents one mechanism by which Bcl-2 prevents staurosporine-induced cell death.	Staurosporine	196-209	B cell leukemia/lymphoma 2	Mus musculus	105-110
9427515-6	1997	Cell death induced by the specific PKC inhibitor, calphostin C was also significantly attenuated in MN9D/Bcl-2 cells indicating that a PKC pathway represents one mechanism by which Bcl-2 prevents staurosporine-induced cell death.	Staurosporine	196-209	B cell leukemia/lymphoma 2	Mus musculus	181-186
9427515-7	1997	Similarly, the Bcl-2 family member, Bcl-X(L) also blocked staurosporine-induced cell death in MN9D cells whereas overexpression of Bcl-X(S) or Bax did not.	Staurosporine	58-71	B cell leukemia/lymphoma 2	Mus musculus	15-20
9427515-7	1997	Similarly, the Bcl-2 family member, Bcl-X(L) also blocked staurosporine-induced cell death in MN9D cells whereas overexpression of Bcl-X(S) or Bax did not.	Staurosporine	58-71	BCL2-like 1	Mus musculus	36-44
9427515-7	1997	Similarly, the Bcl-2 family member, Bcl-X(L) also blocked staurosporine-induced cell death in MN9D cells whereas overexpression of Bcl-X(S) or Bax did not.	Staurosporine	58-71	BCL2-like 1	Mus musculus	36-41
9427515-8	1997	Finally, staurosporine-induced cell death was still blocked by the expression of clones encoding mutations in the Bcl-2 homology domains, BH1 and BH2, as well as C-terminally truncated Bcl-2.	Staurosporine	9-22	B cell leukemia/lymphoma 2	Mus musculus	114-119
9427515-8	1997	Finally, staurosporine-induced cell death was still blocked by the expression of clones encoding mutations in the Bcl-2 homology domains, BH1 and BH2, as well as C-terminally truncated Bcl-2.	Staurosporine	9-22	immunoglobulin kappa variable 1-131	Mus musculus	146-149
9427515-8	1997	Finally, staurosporine-induced cell death was still blocked by the expression of clones encoding mutations in the Bcl-2 homology domains, BH1 and BH2, as well as C-terminally truncated Bcl-2.	Staurosporine	9-22	B cell leukemia/lymphoma 2	Mus musculus	185-190
9427515-9	1997	These data suggest that in the staurosporine-mediated cell death model Bcl-2 is not heterodimerizing to related proteins through these highly conserved structural domains nor does it need to be membrane-anchored.	Staurosporine	31-44	B cell leukemia/lymphoma 2	Mus musculus	71-76
9395855-2	1997	Staurosporine (STS) reportedly potentiates TNF-mediated cytotoxicity in cancer cell lines via inhibition of PKC.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	43-46
9395855-2	1997	Staurosporine (STS) reportedly potentiates TNF-mediated cytotoxicity in cancer cell lines via inhibition of PKC.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	108-111
9395855-2	1997	Staurosporine (STS) reportedly potentiates TNF-mediated cytotoxicity in cancer cell lines via inhibition of PKC.	Staurosporine	15-18	tumor necrosis factor	Homo sapiens	43-46
9395855-2	1997	Staurosporine (STS) reportedly potentiates TNF-mediated cytotoxicity in cancer cell lines via inhibition of PKC.	Staurosporine	15-18	proline rich transmembrane protein 2	Homo sapiens	108-111
9356174-7	1997	The protein kinase inhibitor staurosporine prevented Cx43 phosphorylation and the loss of Cx43 from intercellular junctions.	Staurosporine	29-42	gap junction protein alpha 1	Homo sapiens	53-57
9356174-7	1997	The protein kinase inhibitor staurosporine prevented Cx43 phosphorylation and the loss of Cx43 from intercellular junctions.	Staurosporine	29-42	gap junction protein alpha 1	Homo sapiens	90-94
9395784-9	1997	Tumour necrosis factor alpha (TNF-alpha)-induced membrane expression of PR-3 could be blocked with the RNA synthesis inhibitor actinomycin D, the protein kinase C (PKC) and proteinase A (PKA) inhibitor staurosporine, the specific PKA inhibitor calphostin C, the c-AMP-dependent PKA inhibitor KT5720 and the tyrosine kinase inhibitor genistein in a dose-dependent manner.	Staurosporine	202-215	tumor necrosis factor	Homo sapiens	30-39
9395784-9	1997	Tumour necrosis factor alpha (TNF-alpha)-induced membrane expression of PR-3 could be blocked with the RNA synthesis inhibitor actinomycin D, the protein kinase C (PKC) and proteinase A (PKA) inhibitor staurosporine, the specific PKA inhibitor calphostin C, the c-AMP-dependent PKA inhibitor KT5720 and the tyrosine kinase inhibitor genistein in a dose-dependent manner.	Staurosporine	202-215	proteinase 3	Homo sapiens	72-76
9568534-8	1997	By contrast, treatment with either TPA or the PKC inhibitor staurosporine did not induce tau phosphorylation and induced neurite elaboration.	Staurosporine	60-73	proline rich transmembrane protein 2	Homo sapiens	46-49
9392422-3	1997	The protein kinase C (PKC) inhibitors calphostin C and staurosporine prevented TPA-mediated LDL receptor mRNA induction.	Staurosporine	55-68	protein kinase C alpha	Homo sapiens	22-25
9392422-3	1997	The protein kinase C (PKC) inhibitors calphostin C and staurosporine prevented TPA-mediated LDL receptor mRNA induction.	Staurosporine	55-68	low density lipoprotein receptor	Homo sapiens	92-104
9341183-4	1997	Endothelin-1-induced alpha1b-adrenoreceptor phosphorylation was attenuated by staurosporine or genistein and essentially abolished when both inhibitors were used together.	Staurosporine	78-91	endothelin 1	Rattus norvegicus	0-12
9341183-4	1997	Endothelin-1-induced alpha1b-adrenoreceptor phosphorylation was attenuated by staurosporine or genistein and essentially abolished when both inhibitors were used together.	Staurosporine	78-91	adrenoceptor alpha 1B	Rattus norvegicus	21-43
9359403-9	1997	The protein kinase inhibitors genistein and staurosporine inhibited the increase in 2-deoxyglucose uptake observed with fMLP and GM-CSF, and partly reversed the affinity increase towards that of untreated control cells.	Staurosporine	44-57	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	129-135
9361367-7	1997	Two protein kinase inhibitors, staurosporine and herbimycin, blocked both ADP and thrombin-induced P-selectin expression at 10 mumol/L, but not PAI-1 secretion.	Staurosporine	31-44	coagulation factor II, thrombin	Homo sapiens	82-90
9361367-7	1997	Two protein kinase inhibitors, staurosporine and herbimycin, blocked both ADP and thrombin-induced P-selectin expression at 10 mumol/L, but not PAI-1 secretion.	Staurosporine	31-44	selectin P	Homo sapiens	99-109
9312119-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the TNF-induced synthesis of IL-6.	Staurosporine	0-13	tumor necrosis factor	Mus musculus	97-100
9312119-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the TNF-induced synthesis of IL-6.	Staurosporine	0-13	interleukin 6	Mus musculus	122-126
9314830-9	1997	Studies performed in the presence of second-messenger inhibitors showed that the effect of IL-1 beta on phospholamban transcript levels was blocked by dexamethasone, was insensitive to inhibitors of iNOS, cyclooxygenase, or tyrosine kinases, but was enhanced by the addition of the protein kinase inhibitor staurosporine.	Staurosporine	307-320	interleukin 1 beta	Rattus norvegicus	91-100
9344507-4	1997	LIF production in response to PMA is PKC-dependent since the two PKC inhibitors sphingosine and staurosporine markedly diminished it.	Staurosporine	96-109	LIF interleukin 6 family cytokine	Homo sapiens	0-3
9322916-5	1997	The PACAP-induced [Ca2+]i increase was mimicked by activators of protein kinase A (PKA) and protein kinase C (PKC), Sp-diastereomer of cAMP and 1-oleoyl-2-acetyl-sn-glycerol, and was reduced by inhibitors of PKA and PKC, Rp-diastereomer of cAMP and staurosporine.	Staurosporine	249-262	adenylate cyclase activating polypeptide 1	Rattus norvegicus	4-9
9322916-5	1997	The PACAP-induced [Ca2+]i increase was mimicked by activators of protein kinase A (PKA) and protein kinase C (PKC), Sp-diastereomer of cAMP and 1-oleoyl-2-acetyl-sn-glycerol, and was reduced by inhibitors of PKA and PKC, Rp-diastereomer of cAMP and staurosporine.	Staurosporine	249-262	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	65-81
9322916-5	1997	The PACAP-induced [Ca2+]i increase was mimicked by activators of protein kinase A (PKA) and protein kinase C (PKC), Sp-diastereomer of cAMP and 1-oleoyl-2-acetyl-sn-glycerol, and was reduced by inhibitors of PKA and PKC, Rp-diastereomer of cAMP and staurosporine.	Staurosporine	249-262	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	83-86
9322916-7	1997	It further revealed that PACAP-induced inward currents were mimicked by 1-oleoyl-2-acetyl-sn-glycerol and inhibited by staurosporine, and that Sp-diastereomer of cAMP facilitated Ba2+ currents.	Staurosporine	119-132	adenylate cyclase activating polypeptide 1	Rattus norvegicus	25-30
9358286-6	1997	Additionally, we showed that staurosporin restored metabolic responses that chondrocytes in primary culture exhibit upon interleukin-1 beta treatment (decrease of Alcian blue- positive cells, induction of expression of the 92 kDa gelatinase, nitric oxide production).	Staurosporine	29-41	interleukin 1 beta	Homo sapiens	121-139
9363933-3	1997	VCAM-1 and GM-CSF acted synergistically to stimulate O2- generation which was significantly inhibited by either genistein, a tyrosine kinase inhibitor, or staurosporine, a protein kinase C inhibitor.	Staurosporine	155-168	vascular cell adhesion molecule 1	Homo sapiens	0-6
9363933-3	1997	VCAM-1 and GM-CSF acted synergistically to stimulate O2- generation which was significantly inhibited by either genistein, a tyrosine kinase inhibitor, or staurosporine, a protein kinase C inhibitor.	Staurosporine	155-168	colony stimulating factor 2	Homo sapiens	11-17
9326446-4	1997	The stimulatory effect of TGFbeta1 on IGFBP-3 production was inhibited in a dose-dependent manner by pretreatment with staurosporine, a protein kinase C inhibitor, or with vanadate, a phosphotyrosyl protein phosphatase inhibitor in both MG63 cells and normal HBCs.	Staurosporine	119-132	transforming growth factor beta 1	Homo sapiens	26-34
9326446-4	1997	The stimulatory effect of TGFbeta1 on IGFBP-3 production was inhibited in a dose-dependent manner by pretreatment with staurosporine, a protein kinase C inhibitor, or with vanadate, a phosphotyrosyl protein phosphatase inhibitor in both MG63 cells and normal HBCs.	Staurosporine	119-132	insulin like growth factor binding protein 3	Homo sapiens	38-45
9326446-6	1997	Interestingly, pretreatment of MG63 cells or HBCs with staurosporine, vanadate, or okadoic acid augmented OP-1 stimulation of IGFBP3 production.	Staurosporine	55-68	bone morphogenetic protein 7	Homo sapiens	106-110
9326446-6	1997	Interestingly, pretreatment of MG63 cells or HBCs with staurosporine, vanadate, or okadoic acid augmented OP-1 stimulation of IGFBP3 production.	Staurosporine	55-68	insulin like growth factor binding protein 3	Homo sapiens	126-132
9326446-7	1997	Staurosporine- or vanadate-induced changes in IGFBP-3 protein levels in the presence of TGFbeta1 and OP-1 were associated with corresponding changes in IGFBP-3 mRNA levels in MG63 cells.	Staurosporine	0-13	insulin like growth factor binding protein 3	Homo sapiens	46-53
9326446-7	1997	Staurosporine- or vanadate-induced changes in IGFBP-3 protein levels in the presence of TGFbeta1 and OP-1 were associated with corresponding changes in IGFBP-3 mRNA levels in MG63 cells.	Staurosporine	0-13	transforming growth factor beta 1	Homo sapiens	88-96
9326446-7	1997	Staurosporine- or vanadate-induced changes in IGFBP-3 protein levels in the presence of TGFbeta1 and OP-1 were associated with corresponding changes in IGFBP-3 mRNA levels in MG63 cells.	Staurosporine	0-13	bone morphogenetic protein 7	Homo sapiens	101-105
9328844-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the IL-1-induced secretion of IL-6.	Staurosporine	0-13	interleukin 1 complex	Mus musculus	97-101
9328844-2	1997	Staurosporine and calphostin C, inhibitors of protein kinase C (PKC), significantly enhanced the IL-1-induced secretion of IL-6.	Staurosporine	0-13	interleukin 6	Mus musculus	123-127
9334743-0	1997	Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2.	Staurosporine	29-42	cyclin dependent kinase 2	Homo sapiens	97-101
9334743-2	1997	The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.	Staurosporine	24-37	cyclin dependent kinase 2	Homo sapiens	19-23
9334743-2	1997	The structure of a CDK2 staurosporine complex explains the tight binding of this inhibitor, and suggests features to be exploited in the design of specific inhibitors of CDKs.	Staurosporine	24-37	cyclin dependent kinase 2	Homo sapiens	170-174
9342725-7	1997	That some of the effects of protein kinase C activation were mediated through phospholipase A2 was also indicated by the ability of staurosporine to reduce the Ca2+ accumulation induced by arachidonic acid or the phospholipase A2 activator melittin.	Staurosporine	132-145	phospholipase A2 group IB	Homo sapiens	78-94
9374197-7	1997	Using a more specific PKC substrate, N-terminal acetylated peptide (4-14) from myelin basic protein, we then demonstrated that A beta indeed increased PKC activity and that this activity could be blocked by the PKC inhibitor, staurosporine.	Staurosporine	226-239	protein kinase C, alpha	Rattus norvegicus	22-25
9374197-7	1997	Using a more specific PKC substrate, N-terminal acetylated peptide (4-14) from myelin basic protein, we then demonstrated that A beta indeed increased PKC activity and that this activity could be blocked by the PKC inhibitor, staurosporine.	Staurosporine	226-239	myelin basic protein	Rattus norvegicus	79-99
9374197-7	1997	Using a more specific PKC substrate, N-terminal acetylated peptide (4-14) from myelin basic protein, we then demonstrated that A beta indeed increased PKC activity and that this activity could be blocked by the PKC inhibitor, staurosporine.	Staurosporine	226-239	amyloid beta precursor protein	Rattus norvegicus	127-133
9374197-7	1997	Using a more specific PKC substrate, N-terminal acetylated peptide (4-14) from myelin basic protein, we then demonstrated that A beta indeed increased PKC activity and that this activity could be blocked by the PKC inhibitor, staurosporine.	Staurosporine	226-239	protein kinase C, alpha	Rattus norvegicus	151-154
9374197-7	1997	Using a more specific PKC substrate, N-terminal acetylated peptide (4-14) from myelin basic protein, we then demonstrated that A beta indeed increased PKC activity and that this activity could be blocked by the PKC inhibitor, staurosporine.	Staurosporine	226-239	protein kinase C, alpha	Rattus norvegicus	151-154
9440544-6	1997	A Jak2 kinase inhibitor AG-490, a tyrosine kinase inhibitor genistein, and a phosphatidylinositol 3-kinase inhibitor wortmannin inhibited GM-CSF- and IL-5-induced MAP kinase activation in eosinophils, whereas a protein kinase C inhibitor staurosporine had a weak inhibitory effect.	Staurosporine	238-251	Janus kinase 2	Homo sapiens	2-6
9440544-6	1997	A Jak2 kinase inhibitor AG-490, a tyrosine kinase inhibitor genistein, and a phosphatidylinositol 3-kinase inhibitor wortmannin inhibited GM-CSF- and IL-5-induced MAP kinase activation in eosinophils, whereas a protein kinase C inhibitor staurosporine had a weak inhibitory effect.	Staurosporine	238-251	colony stimulating factor 2	Homo sapiens	138-144
9440544-6	1997	A Jak2 kinase inhibitor AG-490, a tyrosine kinase inhibitor genistein, and a phosphatidylinositol 3-kinase inhibitor wortmannin inhibited GM-CSF- and IL-5-induced MAP kinase activation in eosinophils, whereas a protein kinase C inhibitor staurosporine had a weak inhibitory effect.	Staurosporine	238-251	interleukin 5	Homo sapiens	150-154
9342725-7	1997	That some of the effects of protein kinase C activation were mediated through phospholipase A2 was also indicated by the ability of staurosporine to reduce the Ca2+ accumulation induced by arachidonic acid or the phospholipase A2 activator melittin.	Staurosporine	132-145	phospholipase A2 group IB	Homo sapiens	213-229
9380033-0	1997	Lipopolysaccharide and the glycoside ring of staurosporine induce CD14 expression on bone marrow granulocytes by different mechanisms.	Staurosporine	45-58	CD14 antigen	Mus musculus	66-70
9380033-4	1997	The STP-induced effect was independent of its protein kinase inhibitory activity because several other protein kinase inhibitors, such as the indolocarbazole K-252a, the bisindolylmaleimide RO-31-8220, the perylenequinone calphostin C, and the isoquinolinesulfonamide H7, did not induce CD14 expression.	Staurosporine	4-7	CD14 antigen	Mus musculus	287-291
9380033-6	1997	Three lines of evidence show that the mechanism of CD14 expression induced by STP differs from that induced by LPS: (i) unlike LPS, STP can stimulate BMC from LPS-unresponsive C3H/HeJ mice, (ii) LPS and STP effects are additive at a saturating dose of LPS, and (iii) the protein kinase inhibitor K-252a inhibits the LPS-induced but not STP-induced stimulation.	Staurosporine	78-81	CD14 antigen	Mus musculus	51-55
9379406-8	1997	Pretreatment with the PKC inhibitors staurosporine (100 nM) or calphostin C (500 nM) prevented the Ang II-induced inhibition of IK,ATP.	Staurosporine	37-50	angiotensinogen	Rattus norvegicus	99-105
9316497-6	1997	Staurosporine reduced the downmodulation by low-level IL-8 plus LTB4 or IL-1 beta but not by high-level IL-8 alone.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	54-58
9316497-6	1997	Staurosporine reduced the downmodulation by low-level IL-8 plus LTB4 or IL-1 beta but not by high-level IL-8 alone.	Staurosporine	0-13	interleukin 1 beta	Homo sapiens	72-81
9316497-6	1997	Staurosporine reduced the downmodulation by low-level IL-8 plus LTB4 or IL-1 beta but not by high-level IL-8 alone.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Staurosporine	90-103	Fas (TNF receptor superfamily member 6)	Mus musculus	23-27
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Staurosporine	90-103	Fc receptor, IgG, low affinity III	Mus musculus	50-62
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Staurosporine	90-103	Fc receptor, IgG, low affinity III	Mus musculus	213-225
9292524-7	1997	On the other hand, the CD95 expression induced by Fc gammaRIII stimulation was blocked by staurosporine, but not by EGTA or FK506, and phorbol myristate acetate (PMA) induced CD95 expression in the same manner as Fc gammaRIII, indicating the involvement of PKC in the CD95 expression induced by Fc gammaRIII stimulation.	Staurosporine	90-103	Fc receptor, IgG, low affinity III	Mus musculus	213-225
9326446-7	1997	Staurosporine- or vanadate-induced changes in IGFBP-3 protein levels in the presence of TGFbeta1 and OP-1 were associated with corresponding changes in IGFBP-3 mRNA levels in MG63 cells.	Staurosporine	0-13	insulin like growth factor binding protein 3	Homo sapiens	152-159
9376229-7	1997	Staurosporine, an inhibitor for protein kinases, enhanced the bFGF-induced IL-6 synthesis.	Staurosporine	0-13	fibroblast growth factor 2	Mus musculus	62-66
9376229-7	1997	Staurosporine, an inhibitor for protein kinases, enhanced the bFGF-induced IL-6 synthesis.	Staurosporine	0-13	interleukin 6	Mus musculus	75-79
9285638-7	1997	The effect of glucose and TPA was totally reversed by preincubating the cells with the PKC inhibitors staurosporine (10(-8) mol/L) and Goe 6976 (10(-8) mol/L).	Staurosporine	102-115	proline rich transmembrane protein 2	Homo sapiens	87-90
9275066-6	1997	However, when HTC-TSHr cells were pretreated with calphostin C or staurosporine, inhibitors of protein kinase C, a TSH concentration of 20 mU/ml enhanced generation of inositol phosphates in these cells.	Staurosporine	66-79	thyroid stimulating hormone receptor	Homo sapiens	18-22
9346296-5	1997	GDP and its analogue, guanosine 5"-O-[beta-thio]diphosphate, inhibited the stimulatory effect of GTP[S], whereas the PMA response was prevented by the nonselective PKC inhibitor, staurosporine, but not vice versa.	Staurosporine	179-192	protein kinase C alpha	Homo sapiens	164-167
9288776-4	1997	Cells primed with a low concentration of butyrate that itself did not induce activation of caspase-3 or apoptosis were, nevertheless, rendered highly susceptible to induction of apoptosis by staurosporine (an agent that has recently been shown to act by causing mitochondrial release of cytochrome c).	Staurosporine	191-204	cytochrome c, somatic	Homo sapiens	287-299
9288776-5	1997	Synergy between butyrate and staurosporine was due to the presence of a factor in the cytosol of butyrate-primed cells which enhanced over 7-fold the activation of caspase-3 induced by the addition of cytochrome c and dATP to isolated cytosol.	Staurosporine	29-42	caspase 3	Homo sapiens	164-173
9288776-5	1997	Synergy between butyrate and staurosporine was due to the presence of a factor in the cytosol of butyrate-primed cells which enhanced over 7-fold the activation of caspase-3 induced by the addition of cytochrome c and dATP to isolated cytosol.	Staurosporine	29-42	cytochrome c, somatic	Homo sapiens	201-213
9378766-4	1997	We show that p35 is also protective when apoptosis is induced by staurosporine.	Staurosporine	65-78	interleukin 12A	Homo sapiens	13-16
9282952-3	1997	Such enhancement was prevented by the PKC inhibitors staurosporine and calphostin-C and by down-regulation of PKC and was not related to activation of membrane receptors or Gs proteins or to inhibition of Gi proteins or phosphodiesterases.	Staurosporine	53-66	protein kinase C, gamma	Rattus norvegicus	38-41
9281358-3	1997	It is shown that resident PMo incubated with protein kinase (PK)C inhibitors, staurosporine (SP) and its derivative GF109203-X, showed a several fold increase in the levels of Il6 mRNA in control and CSF-1-primed PMo and a parallel release of large amounts of protein.	Staurosporine	78-91	interleukin 6	Mus musculus	176-179
9350434-2	1997	Since these latter compounds were known to activate NF-kappa B translocation in a redox-sensitive way, we have demonstrated that NF-kappa B activation by PMA was resistant to antioxidant N-acetyl-L-cysteine (NAC) and sensitive to kinase inhibitors staurosporine and H7 while activation by H2O2 or TNF-alpha were not.	Staurosporine	248-261	nuclear factor kappa B subunit 1	Homo sapiens	129-139
9281358-3	1997	It is shown that resident PMo incubated with protein kinase (PK)C inhibitors, staurosporine (SP) and its derivative GF109203-X, showed a several fold increase in the levels of Il6 mRNA in control and CSF-1-primed PMo and a parallel release of large amounts of protein.	Staurosporine	78-91	colony stimulating factor 1 (macrophage)	Mus musculus	200-205
9281358-3	1997	It is shown that resident PMo incubated with protein kinase (PK)C inhibitors, staurosporine (SP) and its derivative GF109203-X, showed a several fold increase in the levels of Il6 mRNA in control and CSF-1-primed PMo and a parallel release of large amounts of protein.	Staurosporine	93-95	interleukin 6	Mus musculus	176-179
9281358-3	1997	It is shown that resident PMo incubated with protein kinase (PK)C inhibitors, staurosporine (SP) and its derivative GF109203-X, showed a several fold increase in the levels of Il6 mRNA in control and CSF-1-primed PMo and a parallel release of large amounts of protein.	Staurosporine	93-95	colony stimulating factor 1 (macrophage)	Mus musculus	200-205
9281358-4	1997	In contrast, SP was shown to have no effect on the release of GM-CSF from control or CSF-1-primed PMo, although it increased by approximately twofold the amount of Csfgm mRNA in CSF-1-primed Mo.	Staurosporine	13-15	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	164-169
9281358-4	1997	In contrast, SP was shown to have no effect on the release of GM-CSF from control or CSF-1-primed PMo, although it increased by approximately twofold the amount of Csfgm mRNA in CSF-1-primed Mo.	Staurosporine	13-15	colony stimulating factor 1 (macrophage)	Mus musculus	178-183
9281358-5	1997	When SP was added 4 h after CSF-1 priming to block CSF-1-induced protein kinase pathways, an increased amount of IL-6 release was again seen but without any increase in Il6 mRNA levels.	Staurosporine	5-7	colony stimulating factor 1 (macrophage)	Mus musculus	28-33
9281358-5	1997	When SP was added 4 h after CSF-1 priming to block CSF-1-induced protein kinase pathways, an increased amount of IL-6 release was again seen but without any increase in Il6 mRNA levels.	Staurosporine	5-7	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
9281358-5	1997	When SP was added 4 h after CSF-1 priming to block CSF-1-induced protein kinase pathways, an increased amount of IL-6 release was again seen but without any increase in Il6 mRNA levels.	Staurosporine	5-7	interleukin 6	Mus musculus	113-117
9305637-8	1997	Although both herbimycin and staurosporine blocked agrin-induced AChR phosphorylation, only herbimycin inhibited the phosphorylation of MuSK.	Staurosporine	29-42	agrin	Homo sapiens	51-56
9281358-10	1997	The addition of SP to CSF-1-primed Mo before LPS, however, further enhanced IL-6 release but not GM-CSF release from the cells.	Staurosporine	16-18	colony stimulating factor 1 (macrophage)	Mus musculus	22-27
9281358-10	1997	The addition of SP to CSF-1-primed Mo before LPS, however, further enhanced IL-6 release but not GM-CSF release from the cells.	Staurosporine	16-18	interleukin 6	Mus musculus	76-80
9283699-6	1997	Determination by immunoassay of cytokine-induced neutrophil chemoattractant (CINC)-1, -2 alpha, -2 beta and -3 in the conditioned medium at 4 h revealed that staurosporine (64 nM) and TPA (49 nM) strongly stimulated the production of CINC-3 (staurosporine, 133.0 +/- 3.8; TPA, 26.7 +/- 1.0; control, 0.32 +/- 0.01 ng ml-1, means +/- s.e.mean from four samples) compared to CINC-1 (staurosporine, 55.0 +/- 1.2; TPA, 12.2 +/- 0.3; control, 0.56 +/- 0.01 ng ml-1), and CINC-2 alpha (staurosporine, 1.09 +/- 0.03; TPA, 0.90 +/- 0.02; control, &lt; 0.10 ng ml-1).	Staurosporine	158-171	C-X-C motif chemokine ligand 1	Rattus norvegicus	32-110
9283699-6	1997	Determination by immunoassay of cytokine-induced neutrophil chemoattractant (CINC)-1, -2 alpha, -2 beta and -3 in the conditioned medium at 4 h revealed that staurosporine (64 nM) and TPA (49 nM) strongly stimulated the production of CINC-3 (staurosporine, 133.0 +/- 3.8; TPA, 26.7 +/- 1.0; control, 0.32 +/- 0.01 ng ml-1, means +/- s.e.mean from four samples) compared to CINC-1 (staurosporine, 55.0 +/- 1.2; TPA, 12.2 +/- 0.3; control, 0.56 +/- 0.01 ng ml-1), and CINC-2 alpha (staurosporine, 1.09 +/- 0.03; TPA, 0.90 +/- 0.02; control, &lt; 0.10 ng ml-1).	Staurosporine	158-171	C-X-C motif chemokine ligand 2	Rattus norvegicus	234-240
9283699-6	1997	Determination by immunoassay of cytokine-induced neutrophil chemoattractant (CINC)-1, -2 alpha, -2 beta and -3 in the conditioned medium at 4 h revealed that staurosporine (64 nM) and TPA (49 nM) strongly stimulated the production of CINC-3 (staurosporine, 133.0 +/- 3.8; TPA, 26.7 +/- 1.0; control, 0.32 +/- 0.01 ng ml-1, means +/- s.e.mean from four samples) compared to CINC-1 (staurosporine, 55.0 +/- 1.2; TPA, 12.2 +/- 0.3; control, 0.56 +/- 0.01 ng ml-1), and CINC-2 alpha (staurosporine, 1.09 +/- 0.03; TPA, 0.90 +/- 0.02; control, &lt; 0.10 ng ml-1).	Staurosporine	158-171	C-X-C motif chemokine ligand 1	Rattus norvegicus	373-379
9568551-5	1997	Additionally, staurosporine (to LPS and PMA) and HBA (to LPS only) inhibited the activation of these mitogen-activated protein kinase (MAPK) isoforms at doses 10-100 fold higher than those required to inhibit maximal TNF alpha production.	Staurosporine	14-27	mitogen-activated protein kinase 3	Homo sapiens	135-139
9568551-5	1997	Additionally, staurosporine (to LPS and PMA) and HBA (to LPS only) inhibited the activation of these mitogen-activated protein kinase (MAPK) isoforms at doses 10-100 fold higher than those required to inhibit maximal TNF alpha production.	Staurosporine	14-27	tumor necrosis factor	Homo sapiens	217-226
9253328-6	1997	Both dibutyryl cAMP and staurosporine increased the basal expression of CLA-1 mRNA.	Staurosporine	24-37	scavenger receptor class B member 1	Homo sapiens	72-77
9253328-7	1997	Although there was no additive effect of ACTH and dibutyryl cAMP, staurosporine slightly enhanced the stimulatory effect of ACTH on the expression of CLA-1 mRNA.	Staurosporine	66-79	proopiomelanocortin	Homo sapiens	124-128
9253328-7	1997	Although there was no additive effect of ACTH and dibutyryl cAMP, staurosporine slightly enhanced the stimulatory effect of ACTH on the expression of CLA-1 mRNA.	Staurosporine	66-79	scavenger receptor class B member 1	Homo sapiens	150-155
9218464-0	1997	Specific activation of a c-Jun NH2-terminal kinase isoform and induction of neurite outgrowth in PC-12 cells by staurosporine.	Staurosporine	112-125	mitogen-activated protein kinase 8	Rattus norvegicus	25-50
9218464-1	1997	Staurosporine, a protein kinase inhibitor, is known to mimic the effect of nerve growth factor (NGF) in promoting neurite outgrowth.	Staurosporine	0-13	nerve growth factor	Rattus norvegicus	75-94
9218464-1	1997	Staurosporine, a protein kinase inhibitor, is known to mimic the effect of nerve growth factor (NGF) in promoting neurite outgrowth.	Staurosporine	0-13	nerve growth factor	Rattus norvegicus	96-99
9218464-2	1997	To elucidate the mechanism by which staurosporine induces neurite outgrowth in PC-12 cells, we performed an in-gel kinase assay using myelin basic protein as a substrate, and found that staurosporine induced the activation of a kinase with an apparent molecular mass of 57 kDa.	Staurosporine	36-49	myelin basic protein	Rattus norvegicus	134-154
9218464-2	1997	To elucidate the mechanism by which staurosporine induces neurite outgrowth in PC-12 cells, we performed an in-gel kinase assay using myelin basic protein as a substrate, and found that staurosporine induced the activation of a kinase with an apparent molecular mass of 57 kDa.	Staurosporine	186-199	myelin basic protein	Rattus norvegicus	134-154
9218464-7	1997	Furthermore, staurosporine induced immediate-early genes including Nur77 and fos, but not jun.	Staurosporine	13-26	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	67-72
9218464-7	1997	Furthermore, staurosporine induced immediate-early genes including Nur77 and fos, but not jun.	Staurosporine	13-26	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-80
9218464-9	1997	Taken together, these results indicate staurosporine specifically activates a JNK isoform, which may contribute to biological activities including neurite outgrowth.	Staurosporine	39-52	mitogen-activated protein kinase 8	Rattus norvegicus	78-81
9211864-9	1997	Similar affinity changes were observed with 2-DOG following exposure of IL-3-stimulated cells to the protein kinase inhibitors, genistein and staurosporine.	Staurosporine	142-155	interleukin 3	Canis lupus familiaris	72-76
9223368-9	1997	Flow cytometric analysis indicates that the mechanism of staurosporine-induced apoptosis may be through decrease of Bcl-2 in treated DP cells or through modulation of cell cycle regulators.	Staurosporine	57-70	BCL2 apoptosis regulator	Homo sapiens	116-121
9201973-3	1997	In the present study, Bcl-2 suppressed cell death of N18TG neuroglioma cells caused by various apoptotic stresses, including etoposide, staurosporine, anisomycin, and ultraviolet irradiation.	Staurosporine	136-149	BCL2 apoptosis regulator	Homo sapiens	22-27
19856280-0	1997	Staurosporine-induced apoptosis of immortalized mouse proximal tubule cells is modulated by bcl-2 expression level.	Staurosporine	0-13	B cell leukemia/lymphoma 2	Mus musculus	92-97
9202052-7	1997	Staurosporine, a protein kinase C inhibitor, also blocked stretch-induced increase of VEGF expression.	Staurosporine	0-13	vascular endothelial growth factor A	Rattus norvegicus	86-90
9185777-7	1997	Staurosporine, which induced a much greater level of hepatocyte apoptosis, produced a concomitant increase in CPP32/Mch3alpha processing as shown by the appearance of the p17/p19 subunits and the corresponding increase in CPP32-like protease activity.	Staurosporine	0-13	caspase 3	Rattus norvegicus	110-115
9185777-7	1997	Staurosporine, which induced a much greater level of hepatocyte apoptosis, produced a concomitant increase in CPP32/Mch3alpha processing as shown by the appearance of the p17/p19 subunits and the corresponding increase in CPP32-like protease activity.	Staurosporine	0-13	caspase 3	Rattus norvegicus	222-227
9185777-8	1997	Apoptosis, CPP32/Mch3alpha processing and the increase in CPP32-like protease activity induced by TGF-beta1 and staurosporine were abolished in hepatocytes pretreated with Z-Asp-Glu-Val-Asp (OMe) fluoromethylketone (Z-DEVD.FMK) or Z-Val-Ala-Asp (OMe) fluoromethylketone (Z-VAD.FMK).	Staurosporine	112-125	caspase 3	Rattus norvegicus	58-63
9169347-7	1997	In contrast, staurosporine and calphostin C, inhibitors of PKC, suppressed IL-1-stimulated, but not PTH-stimulated, IL-6/ IL-11 production.	Staurosporine	13-26	interleukin 1 alpha	Homo sapiens	75-79
9164964-5	1997	Through the use of genistein and staurosporine, potent inhibitors of tyrosine kinases (TK) and protein kinase C (PKC), respectively, Leu-13-induced L-selectin down-modulation was demonstrated to involve a TK-dependent, PKC-independent pathway, and was attributed to increased L-selectin shedding from surface membranes.	Staurosporine	33-46	interferon induced transmembrane protein 1	Homo sapiens	133-139
9164964-5	1997	Through the use of genistein and staurosporine, potent inhibitors of tyrosine kinases (TK) and protein kinase C (PKC), respectively, Leu-13-induced L-selectin down-modulation was demonstrated to involve a TK-dependent, PKC-independent pathway, and was attributed to increased L-selectin shedding from surface membranes.	Staurosporine	33-46	selectin L	Homo sapiens	148-158
9164964-5	1997	Through the use of genistein and staurosporine, potent inhibitors of tyrosine kinases (TK) and protein kinase C (PKC), respectively, Leu-13-induced L-selectin down-modulation was demonstrated to involve a TK-dependent, PKC-independent pathway, and was attributed to increased L-selectin shedding from surface membranes.	Staurosporine	33-46	selectin L	Homo sapiens	276-286
9164964-7	1997	In sharp contrast, PMA and anti-CD3 mAb down-regulate L-selectin via a staurosporine-sensitive, genistein-resistant pathway that is closely linked to lymphocyte proliferation.	Staurosporine	71-84	selectin L	Homo sapiens	54-64
9166752-7	1997	PKC stimulation with phorbol 12,13-dibutyrate produced an inhibition of 67%, whereas the PKC inhibitors staurosporine and PKC inhibitory peptide enhanced the responses elicited by Ap5A to 40% in both cases.	Staurosporine	104-117	protein kinase C, gamma	Rattus norvegicus	89-92
9166752-7	1997	PKC stimulation with phorbol 12,13-dibutyrate produced an inhibition of 67%, whereas the PKC inhibitors staurosporine and PKC inhibitory peptide enhanced the responses elicited by Ap5A to 40% in both cases.	Staurosporine	104-117	protein kinase C, gamma	Rattus norvegicus	89-92
9269528-8	1997	In contrast, pretreatment with the protein kinase C inhibitor staurosporine had no effect on PAF-induced tyrosine phosphorylation, but did inhibit PAF-induced O2- generation.	Staurosporine	62-75	PCNA clamp associated factor	Homo sapiens	147-150
9260909-1	1997	7-hydroxystaurosporine (UCN-01) is a more selective protein kinase C inhibitor than staurosporine.	Staurosporine	9-22	urocortin	Homo sapiens	24-27
9399104-4	1997	Pre-exposure of eosinophils to staurosporine resulted in blockage of SP-induced EDN release in a dose-dependent mode.	Staurosporine	31-44	tachykinin precursor 1	Homo sapiens	69-71
9399104-4	1997	Pre-exposure of eosinophils to staurosporine resulted in blockage of SP-induced EDN release in a dose-dependent mode.	Staurosporine	31-44	ribonuclease A family member 2	Homo sapiens	80-83
9401820-10	1997	However, staurosporine produced an additional increase in FSH-stimulated gamma-GTP activity and this effect was also observed when cells were stimulated with dbcAMP.	Staurosporine	9-22	inactive glutathione hydrolase 2	Homo sapiens	73-82
9291832-4	1997	The PKC inhibitors, calphostin C, staurosporine and chelerythrine, partially reduced GH release in response to GRF and GHRP-2 at doses which selectively inhibit PKC activity.	Staurosporine	34-47	somatoliberin	Ovis aries	111-114
9224725-3	1997	The induction of OPN mRNA by TPA was dose dependently inhibited by staurosporine (0.4-10.0 nM) and chelerythrine (0.1-5.0 microM), indicating that OPN expression requires PKC activation.	Staurosporine	67-80	secreted phosphoprotein 1	Homo sapiens	17-20
9224725-3	1997	The induction of OPN mRNA by TPA was dose dependently inhibited by staurosporine (0.4-10.0 nM) and chelerythrine (0.1-5.0 microM), indicating that OPN expression requires PKC activation.	Staurosporine	67-80	secreted phosphoprotein 1	Homo sapiens	147-150
9224627-0	1997	Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.	Staurosporine	0-13	interleukin 2	Mus musculus	43-56
9224627-0	1997	Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.	Staurosporine	0-13	interleukin 1 alpha	Mus musculus	88-106
9224627-0	1997	Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.	Staurosporine	0-13	epilepsy 4	Mus musculus	110-113
9224627-3	1997	A 1 h pulse of staurosporine was found to strongly potentiate the induction of IL2 by IL1alpha in these cells.	Staurosporine	15-28	interleukin 2	Mus musculus	79-82
9224627-3	1997	A 1 h pulse of staurosporine was found to strongly potentiate the induction of IL2 by IL1alpha in these cells.	Staurosporine	15-28	interleukin 1 alpha	Mus musculus	86-94
9224627-6	1997	A 1 h pulse of staurosporine was also found to induce IL2 production on its own, activate the transcription factor nuclear factor kappaB (NFkappaB) and increase the expression of a NFkappaB-linked reporter gene.	Staurosporine	15-28	interleukin 2	Mus musculus	54-57
9224627-6	1997	A 1 h pulse of staurosporine was also found to induce IL2 production on its own, activate the transcription factor nuclear factor kappaB (NFkappaB) and increase the expression of a NFkappaB-linked reporter gene.	Staurosporine	15-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	138-146
9224627-6	1997	A 1 h pulse of staurosporine was also found to induce IL2 production on its own, activate the transcription factor nuclear factor kappaB (NFkappaB) and increase the expression of a NFkappaB-linked reporter gene.	Staurosporine	15-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	181-189
9224627-8	1997	Ro 31-8220 was again without effect, although both staurosporine and Ro 31-8220 blocked the activation of NFkappaB by PMA.	Staurosporine	51-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	106-114
9224627-9	1997	Finally, staurosporine caused the translocation of PKC-alpha and -epsilon, and to a lesser extent PKC-beta, but not PKC-&amp;theta; or -zeta, from the cytosol to the membrane, although a similar effect was observed with Ro 31-8220.	Staurosporine	9-22	protein kinase C, alpha	Mus musculus	51-60
9224627-9	1997	Finally, staurosporine caused the translocation of PKC-alpha and -epsilon, and to a lesser extent PKC-beta, but not PKC-&amp;theta; or -zeta, from the cytosol to the membrane, although a similar effect was observed with Ro 31-8220.	Staurosporine	9-22	protein kinase C, beta	Mus musculus	98-106
9224627-9	1997	Finally, staurosporine caused the translocation of PKC-alpha and -epsilon, and to a lesser extent PKC-beta, but not PKC-&amp;theta; or -zeta, from the cytosol to the membrane, although a similar effect was observed with Ro 31-8220.	Staurosporine	9-22	protein kinase C, alpha	Mus musculus	51-54
9224627-11	1997	Furthermore, the potentiating effect of staurosporine on IL1alpha action does not involve PKC inhibition, and is likely to be at the level of NFkappaB activation.	Staurosporine	40-53	interleukin 1 alpha	Mus musculus	57-65
9224627-11	1997	Furthermore, the potentiating effect of staurosporine on IL1alpha action does not involve PKC inhibition, and is likely to be at the level of NFkappaB activation.	Staurosporine	40-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-150
9182566-7	1997	IL-8 production by OA or VA was inhibited by protein kinase inhibitors, including staurosporine, H-7, K252a, herbimycin A, and genistein.	Staurosporine	82-95	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
9227606-7	1997	However, pHi acidification stimulated protein kinase C (PKC) activity and inhibition of PKC by PKC inhibitors (bisindolylmaleimide, calphostin C, or staurosporine) or prolonged exposure to phorbol ester abrogated the inhibitory effect of pHi acidification on cell Pi uptake.	Staurosporine	149-162	glucose-6-phosphate isomerase	Homo sapiens	9-12
9182723-5	1997	Two of the seven kinase inhibitors, staurosporine (St) and bisindolylmaleimide I (BI), resulted in the dephosphorylation and nuclear localization of NFATp.	Staurosporine	36-49	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	Mus musculus	149-154
9182723-5	1997	Two of the seven kinase inhibitors, staurosporine (St) and bisindolylmaleimide I (BI), resulted in the dephosphorylation and nuclear localization of NFATp.	Staurosporine	51-53	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	Mus musculus	149-154
9209506-6	1997	Staurosporine-sensitive agonist-dependent C5aR internalization could be detected, suggesting that C5aR phosphorylation, most likely of the C terminus, participates in this type of internalization.	Staurosporine	0-13	complement C5a receptor 1	Homo sapiens	42-46
9209506-6	1997	Staurosporine-sensitive agonist-dependent C5aR internalization could be detected, suggesting that C5aR phosphorylation, most likely of the C terminus, participates in this type of internalization.	Staurosporine	0-13	complement C5a receptor 1	Homo sapiens	98-102
9177393-5	1997	The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein.	Staurosporine	106-119	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	4-9
9177393-5	1997	The c-jun and c-fos mRNA stimulation elicited by TPA was reduced by the PKC inhibitors, chelerythrine and staurosporine, and could not be mimicked by 4alpha-phorbol 12,13-didecanoate (a phorbol ester that fails to activate PKC), whereas the stimulation induced by EGF was diminished by the PTK inhibitor, genistein.	Staurosporine	106-119	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
9166725-1	1997	We characterized the activation of interleukin-1beta-converting enzyme (ICE)-like proteases (caspases) in human neuroblastoma cells (SH-SY5Y) following challenge with staurosporine, an established agent known to induce apoptosis.	Staurosporine	167-180	caspase 1	Homo sapiens	72-75
9166725-1	1997	We characterized the activation of interleukin-1beta-converting enzyme (ICE)-like proteases (caspases) in human neuroblastoma cells (SH-SY5Y) following challenge with staurosporine, an established agent known to induce apoptosis.	Staurosporine	167-180	caspase 1	Homo sapiens	93-101
9166725-4	1997	Furthermore, the hydrolysis of the CPP32 substrate acetyl-DEVD-7-amido-4-methylcoumarin was detected as early as 3 h and became maximal at 6 h after staurosporine challenge, suggesting a delayed and sustained period of CPP32-like activation.	Staurosporine	149-162	caspase 3	Homo sapiens	35-40
9166725-4	1997	Furthermore, the hydrolysis of the CPP32 substrate acetyl-DEVD-7-amido-4-methylcoumarin was detected as early as 3 h and became maximal at 6 h after staurosporine challenge, suggesting a delayed and sustained period of CPP32-like activation.	Staurosporine	149-162	caspase 3	Homo sapiens	219-224
9166725-7	1997	Following staurosporine challenge there was a condensing of CPP32 immunofluorescence from the cytoplasm to a region adjacent to the plasma membrane.	Staurosporine	10-23	caspase 3	Homo sapiens	60-65
9166725-9	1997	It is important that a pan ICE inhibitor [carbobenzoxy-Asp-CH2OC(O)-2,6-dichlorobenzene] was able to attenuate lactate dehydrogenase release and PARP and CPP32 cleavage and altered immunohistochemical staining patterns for PARP and CPP32 following staurosporine challenge.	Staurosporine	248-261	caspase 1	Homo sapiens	27-30
9271155-5	1997	Application of PKC inhibitors such as 100 microM H-7 or 10 microM staurosporine and PKCI(19-31) prior to the application of PDBu significantly decreased the depressing effects of PDBu.	Staurosporine	66-79	protein kinase C iota	Homo sapiens	15-18
9174069-10	1997	Moreover, voltage-activated Ca2+ currents were partially blocked by CCK-8, and this effect was enhanced by intracellular application of GTPgammaS (300 microM) or a protein phosphatase inhibitor, okadaic acid (100 nM), and attenuated by GDPbetaS (300 microM) or a protein kinase inhibitor, staurosporin (400 nM).	Staurosporine	289-301	carbonic anhydrase 2	Rattus norvegicus	28-31
9184081-0	1997	Modulation in cell cycle and cyclin B1 expression in irradiated HeLa cells and normal human skin fibroblasts treated with staurosporine and caffeine.	Staurosporine	122-135	cyclin B1	Homo sapiens	29-38
9184081-3	1997	Caffeine and staurosporine were equally effective in attenuating both the radiation-induced increase in cyclin B1 expression and the prolongation of G2 in synchronous and asynchronous HeLa cell populations.	Staurosporine	13-26	cyclin B1	Homo sapiens	104-113
9184081-4	1997	Staurosporine treatment was less effective in down-regulating cyclin B1 expression in asynchronous HeLa cells at earlier time points following irradiation when compared to caffeine-treated cells.	Staurosporine	0-13	cyclin B1	Homo sapiens	62-71
9184081-6	1997	An increase in cyclin B1 expression was also observed in irradiated HSF cells (synchronous and asynchronous), which decreased when the cells were treated with staurosporine or caffeine.	Staurosporine	159-172	cyclin B1	Homo sapiens	15-24
9184081-6	1997	An increase in cyclin B1 expression was also observed in irradiated HSF cells (synchronous and asynchronous), which decreased when the cells were treated with staurosporine or caffeine.	Staurosporine	159-172	interleukin 6	Homo sapiens	68-71
9184081-8	1997	These results suggest that both staurosporine and caffeine treatments act on different pathways of cell cycle control in normal and transformed cells, in terms of attenuation of G2 block and diminution of elevated levels of cyclin B1 expression, in response to radiation.	Staurosporine	32-45	cyclin B1	Homo sapiens	224-233
9223064-0	1997	Bax accelerates staurosporine-induced but suppresses nigericin-induced neuronal cell death.	Staurosporine	16-29	BCL2-associated X protein	Mus musculus	0-3
9223064-4	1997	As expected, over-expression of Bax in MN9D cells accelerated staurosporine-induced cell death as measured by the MTT reduction assay (62.3% survival in MN9D/Neo vs 27.0% survival in MN9D/Bax).	Staurosporine	62-75	BCL2-associated X protein	Mus musculus	32-35
9223064-4	1997	As expected, over-expression of Bax in MN9D cells accelerated staurosporine-induced cell death as measured by the MTT reduction assay (62.3% survival in MN9D/Neo vs 27.0% survival in MN9D/Bax).	Staurosporine	62-75	BCL2-associated X protein	Mus musculus	188-191
9153259-5	1997	Pertussis toxin or the protein kinase C inhibitor, staurosporine, completely blocked chemoattractant receptor-induced phosphorylation of L-selectin.	Staurosporine	51-64	selectin L	Homo sapiens	137-147
9283699-6	1997	Determination by immunoassay of cytokine-induced neutrophil chemoattractant (CINC)-1, -2 alpha, -2 beta and -3 in the conditioned medium at 4 h revealed that staurosporine (64 nM) and TPA (49 nM) strongly stimulated the production of CINC-3 (staurosporine, 133.0 +/- 3.8; TPA, 26.7 +/- 1.0; control, 0.32 +/- 0.01 ng ml-1, means +/- s.e.mean from four samples) compared to CINC-1 (staurosporine, 55.0 +/- 1.2; TPA, 12.2 +/- 0.3; control, 0.56 +/- 0.01 ng ml-1), and CINC-2 alpha (staurosporine, 1.09 +/- 0.03; TPA, 0.90 +/- 0.02; control, &lt; 0.10 ng ml-1).	Staurosporine	158-171	C-X-C motif chemokine ligand 3	Rattus norvegicus	466-472
9283699-10	1997	Staurosporine (64 nM) and TPA (49 nM) enhanced the level of CINC-3 mRNA time-dependently, but had no effect on GAPDH mRNA levels.	Staurosporine	0-13	C-X-C motif chemokine ligand 2	Rattus norvegicus	60-66
9283699-15	1997	Both the staurosporine- and the TPA-induced increase in CINC-3 mRNA levels were suppressed by H-7 and genistein.	Staurosporine	9-22	C-X-C motif chemokine ligand 2	Rattus norvegicus	56-62
9178828-6	1997	These inhibitory effects of TPA and DG were antagonized by inhibitors of PKC such as H-7 and staurosporin, and by amiloride, an inhibitor of Na+/H+ antiporter.	Staurosporine	93-105	protein kinase C beta	Homo sapiens	73-76
9225074-7	1997	Both protein kinase C inhibitors studied (staurosporine and CGP 41251) exhibited variable effects on cell surface antigen (HLA, ICAM-1, CD59) expression, suggesting complex interactions between PKC-dependent and -independent mechanisms in the regulation of surface antigen expression in these cell lines.	Staurosporine	42-55	intercellular adhesion molecule 1	Homo sapiens	128-134
9168824-2	1997	In this report, we show that both constitutive and CSF-1-induced IL-6 release were enhanced and prolonged in the presence of the PKC inhibitors, staurosporine (SP) and its derivative, GF-109203X.	Staurosporine	145-158	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
9168824-2	1997	In this report, we show that both constitutive and CSF-1-induced IL-6 release were enhanced and prolonged in the presence of the PKC inhibitors, staurosporine (SP) and its derivative, GF-109203X.	Staurosporine	145-158	interleukin 6	Mus musculus	65-69
9168824-2	1997	In this report, we show that both constitutive and CSF-1-induced IL-6 release were enhanced and prolonged in the presence of the PKC inhibitors, staurosporine (SP) and its derivative, GF-109203X.	Staurosporine	160-162	colony stimulating factor 1 (macrophage)	Mus musculus	51-56
9168824-2	1997	In this report, we show that both constitutive and CSF-1-induced IL-6 release were enhanced and prolonged in the presence of the PKC inhibitors, staurosporine (SP) and its derivative, GF-109203X.	Staurosporine	160-162	interleukin 6	Mus musculus	65-69
9168824-4	1997	SP was also shown to activate constitutive IL-6 release by blood monocytes and elicited PM phi but had no effect on their responsiveness to CSF-1.	Staurosporine	0-2	interleukin 6	Mus musculus	43-47
9225074-7	1997	Both protein kinase C inhibitors studied (staurosporine and CGP 41251) exhibited variable effects on cell surface antigen (HLA, ICAM-1, CD59) expression, suggesting complex interactions between PKC-dependent and -independent mechanisms in the regulation of surface antigen expression in these cell lines.	Staurosporine	42-55	CD59 molecule (CD59 blood group)	Homo sapiens	136-140
9225074-10	1997	Staurosporine induced the appearance of cells with high DNA content in HL-60/ADR, but not in HL-60/VCR cells.	Staurosporine	0-13	aldo-keto reductase family 1 member B	Homo sapiens	77-80
9225074-1	1997	Protein kinase inhibitors staurosporine and CGP 41251, a benzoylated derivative of staurosporine with selective PKC inhibitory activity, reversed the decreased rhodamine 123 uptake in HL-60/VCR (with Pgp-mediated drug resistance) but not in HL-60/ADR (MRP-mediated drug resistance) cells.	Staurosporine	26-39	phosphoglycolate phosphatase	Homo sapiens	200-203
9250823-6	1997	Staurosporine, an additional inhibitor of serine kinases also abrogated the effect of IL4 on CD23 expression.	Staurosporine	0-13	interleukin 4	Homo sapiens	86-89
9250823-6	1997	Staurosporine, an additional inhibitor of serine kinases also abrogated the effect of IL4 on CD23 expression.	Staurosporine	0-13	Fc epsilon receptor II	Homo sapiens	93-97
9150270-5	1997	Staurosporine also increased membrane association of MARCKS in a PKC-independent manner, as no change in MARCKS phosphorylation was noted and bis-indolylmaleimide (a more specific PKC inhibitor) did not alter MARCKS distribution.	Staurosporine	0-13	myristoylated alanine rich protein kinase C substrate	Homo sapiens	53-59
9225074-1	1997	Protein kinase inhibitors staurosporine and CGP 41251, a benzoylated derivative of staurosporine with selective PKC inhibitory activity, reversed the decreased rhodamine 123 uptake in HL-60/VCR (with Pgp-mediated drug resistance) but not in HL-60/ADR (MRP-mediated drug resistance) cells.	Staurosporine	26-39	aldo-keto reductase family 1 member B	Homo sapiens	247-250
9225074-1	1997	Protein kinase inhibitors staurosporine and CGP 41251, a benzoylated derivative of staurosporine with selective PKC inhibitory activity, reversed the decreased rhodamine 123 uptake in HL-60/VCR (with Pgp-mediated drug resistance) but not in HL-60/ADR (MRP-mediated drug resistance) cells.	Staurosporine	26-39	ATP binding cassette subfamily C member 1	Homo sapiens	252-255
9108028-7	1997	Expression of catalytically active Akt mutants in BAF/3 cells expressing IL-2R beta[A0]delta S promotes the expression of Bcl-2 and c-myc, inhibits apoptosis induced by IL-3 deprivation or staurosporine, and stimulates cell cycle progression.	Staurosporine	189-202	thymoma viral proto-oncogene 1	Mus musculus	35-38
9108028-7	1997	Expression of catalytically active Akt mutants in BAF/3 cells expressing IL-2R beta[A0]delta S promotes the expression of Bcl-2 and c-myc, inhibits apoptosis induced by IL-3 deprivation or staurosporine, and stimulates cell cycle progression.	Staurosporine	189-202	interleukin 2 receptor, beta chain	Mus musculus	73-83
9108035-5	1997	A similar shift in the localization of Bax from the cytosol to membranes was observed in HL-60 leukemia cells upon induction of apoptosis by staurosporine.	Staurosporine	141-154	BCL2 associated X, apoptosis regulator	Homo sapiens	39-42
9141489-7	1997	In contrast, in apoptotic cells treated with a PKC inhibitor, staurosporine, no effect on bcl-X(L) or bax expression was observed.	Staurosporine	62-75	proline rich transmembrane protein 2	Homo sapiens	47-50
9150270-5	1997	Staurosporine also increased membrane association of MARCKS in a PKC-independent manner, as no change in MARCKS phosphorylation was noted and bis-indolylmaleimide (a more specific PKC inhibitor) did not alter MARCKS distribution.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	65-68
9150270-5	1997	Staurosporine also increased membrane association of MARCKS in a PKC-independent manner, as no change in MARCKS phosphorylation was noted and bis-indolylmaleimide (a more specific PKC inhibitor) did not alter MARCKS distribution.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	180-183
9150270-6	1997	Staurosporine inhibited the phorbol ester-induced translocation of MARCKS but not of PKC alpha in both CD pretreated and untreated cells.	Staurosporine	0-13	myristoylated alanine rich protein kinase C substrate	Homo sapiens	67-73
9120020-7	1997	Next, we showed that apoptosis induced by TNF and staurosporine were blocked by z-DEVD-CH2F, an inhibitor of CPP32-like cysteine protease, suggesting the involvement of CPP32-like protease in both apoptosis signaling pathways.	Staurosporine	50-63	caspase 3	Homo sapiens	109-114
9120020-7	1997	Next, we showed that apoptosis induced by TNF and staurosporine were blocked by z-DEVD-CH2F, an inhibitor of CPP32-like cysteine protease, suggesting the involvement of CPP32-like protease in both apoptosis signaling pathways.	Staurosporine	50-63	cathepsin B	Homo sapiens	120-137
9120020-7	1997	Next, we showed that apoptosis induced by TNF and staurosporine were blocked by z-DEVD-CH2F, an inhibitor of CPP32-like cysteine protease, suggesting the involvement of CPP32-like protease in both apoptosis signaling pathways.	Staurosporine	50-63	caspase 3	Homo sapiens	169-174
9084431-2	1997	Here we report the ability of peptide inhibitors of ICE-like proteases to inhibit apoptosis of cultured cerebellar granule neurones caused by reduction of extracellular K+ levels and by the broad-spectrum protein kinase inhibitor staurosporine.	Staurosporine	230-243	caspase 1	Homo sapiens	52-55
9084431-4	1997	The ICE-like protease inhibitor benzyloxycarbonyl-Val-Ala-Asp (O-methyl)fluoromethyl ketone (zVAD-fmk) was found to be extremely effective at preventing staurosporine-induced death of cerebellar granule neurones and yet was completely ineffective in preventing K+ deprivation-induced death.	Staurosporine	153-166	caspase 1	Homo sapiens	4-7
9084431-5	1997	Staurosporine induced cleavage of the 116-kDa poly (ADP-ribose) polymerase enzyme, a substrate of ICE-like proteases, to the 85-kDa product, and this cleavage was also blocked by zVAD.	Staurosporine	0-13	caspase 1	Homo sapiens	98-101
9084433-3	1997	Two irreversible inhibitors of the interleukin-1 beta converting enzyme (ICE) and related proteases, Z-Val-Ala-Asp-CH2F and acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone, blocked neuronal death produced by A beta(25-35), staurosporine, and NMDA to differing extents.	Staurosporine	218-231	caspase 1	Rattus norvegicus	35-71
9084433-3	1997	Two irreversible inhibitors of the interleukin-1 beta converting enzyme (ICE) and related proteases, Z-Val-Ala-Asp-CH2F and acetyl-Tyr-Val-Ala-Asp-chloromethyl ketone, blocked neuronal death produced by A beta(25-35), staurosporine, and NMDA to differing extents.	Staurosporine	218-231	caspase 1	Rattus norvegicus	73-76
9084441-0	1997	Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis.	Staurosporine	36-49	carbonic anhydrase 2	Rattus norvegicus	0-3
9084441-5	1997	Staurosporine-induced neuronal apoptosis was also significantly reduced when the culture medium was supplemented with 10 or 30 mM K+, suggesting that Ca2+ influx via voltage-sensitive Ca2+ channels reduces this apoptotic cell death.	Staurosporine	0-13	carbonic anhydrase 2	Rattus norvegicus	150-153
9084441-5	1997	Staurosporine-induced neuronal apoptosis was also significantly reduced when the culture medium was supplemented with 10 or 30 mM K+, suggesting that Ca2+ influx via voltage-sensitive Ca2+ channels reduces this apoptotic cell death.	Staurosporine	0-13	carbonic anhydrase 2	Rattus norvegicus	184-187
9103481-5	1997	In the presence of the protein kinase C inhibitor staurosporine, dexmedetomidine reduced AVP-stimulated Pf by 70% to 75% compared with the complete inhibition without staurosporine.	Staurosporine	50-63	arginine vasopressin	Rattus norvegicus	89-92
9083268-6	1997	The effects of insulin also were inhibited by staurosporin and calphostin C, which are dissimilar inhibitors of PKC.	Staurosporine	46-58	insulin	Homo sapiens	15-22
9101406-9	1997	The inhibition of GIRK activity by mGluR1a was suppressed by a broad-specificity protein kinase inhibitor, staurosporine, and by a specific protein kinase C (PKC) inhibitor, bis-indolylmaleimide, but not by PTX, Ca(2-)chelation, or calphostin C.	Staurosporine	107-120	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	18-22
9083268-6	1997	The effects of insulin also were inhibited by staurosporin and calphostin C, which are dissimilar inhibitors of PKC.	Staurosporine	46-58	proline rich transmembrane protein 2	Homo sapiens	112-115
9178968-9	1997	In contrast, LPS-stimulated TNF-alpha secretion was markedly inhibited by not only herbimycin A or genistein, but also staurosporin.	Staurosporine	119-131	tumor necrosis factor	Homo sapiens	28-37
9087589-8	1997	PKC inhibitors (H7 and staurosporine) abolished myogenic contraction but did not depress the increase in the fluorescence ratio.	Staurosporine	23-36	protein kinase C, gamma	Rattus norvegicus	0-3
9052685-7	1997	Staurosporine also prevented AraC-induced MDR1 overexpression.	Staurosporine	0-13	ATP binding cassette subfamily B member 1	Homo sapiens	42-46
9134219-7	1997	Staurosporine also synergistically potentiated the stimulating effect of interleukin-1 beta (IL-1 beta), but not that of the adenylyl cyclase activator, forskolin, on NO2- production and iNOS protein abundance.	Staurosporine	0-13	interleukin 1 beta	Rattus norvegicus	73-91
9134219-7	1997	Staurosporine also synergistically potentiated the stimulating effect of interleukin-1 beta (IL-1 beta), but not that of the adenylyl cyclase activator, forskolin, on NO2- production and iNOS protein abundance.	Staurosporine	0-13	interleukin 1 beta	Rattus norvegicus	93-102
9134219-7	1997	Staurosporine also synergistically potentiated the stimulating effect of interleukin-1 beta (IL-1 beta), but not that of the adenylyl cyclase activator, forskolin, on NO2- production and iNOS protein abundance.	Staurosporine	0-13	nitric oxide synthase 2	Rattus norvegicus	187-191
9134219-9	1997	The effect of staurosporine on both basal and IL-1 beta-stimulated NO2- production was concentration-dependent with an apparent maximum at 3 nM.	Staurosporine	14-27	interleukin 1 beta	Rattus norvegicus	46-55
9134219-12	1997	Staurosporine did not influence basal activity of the transcription factors CREB and nuclear factor kappa B (NF-kappa B), but increased that of C/EBP.	Staurosporine	0-13	CCAAT/enhancer binding protein gamma	Rattus norvegicus	144-149
9134219-13	1997	Moreover, staurosporine significantly augmented the activation of C/EBP by IL-1 beta and forskolin.	Staurosporine	10-23	CCAAT/enhancer binding protein gamma	Rattus norvegicus	66-71
9134219-13	1997	Moreover, staurosporine significantly augmented the activation of C/EBP by IL-1 beta and forskolin.	Staurosporine	10-23	interleukin 1 beta	Rattus norvegicus	75-84
9048615-6	1997	TNF alpha action on PAI-1, like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate (a stimulator of protein kinase C) and strongly reduced by staurosporine (an inhibitor of the protein kinase C).	Staurosporine	191-204	tumor necrosis factor	Rattus norvegicus	0-9
9048615-6	1997	TNF alpha action on PAI-1, like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate (a stimulator of protein kinase C) and strongly reduced by staurosporine (an inhibitor of the protein kinase C).	Staurosporine	191-204	serpin family E member 1	Rattus norvegicus	20-25
9048615-6	1997	TNF alpha action on PAI-1, like that of TGF alpha demonstrated previously, was masked by a preexposure to phorbol myristate acetate (a stimulator of protein kinase C) and strongly reduced by staurosporine (an inhibitor of the protein kinase C).	Staurosporine	191-204	transforming growth factor alpha	Rattus norvegicus	40-49
9052685-8	1997	These data show that intermediate-strength electric fields inhibit cytosolic PKC and suggest that electric fields and pharmacological inhibitors of PKC, such as staurosporine, affect cytosolic PKC activity and AraC-induced MDR1 overexpression through related mechanisms.	Staurosporine	161-174	ATP binding cassette subfamily B member 1	Homo sapiens	223-227
9071558-0	1997	TNF-mediated cytotoxicity of L929 cells: role of staurosporine in enhancement of cytotoxicity and translocation of protein kinase C isozymes.	Staurosporine	49-62	tumor necrosis factor	Mus musculus	0-3
9013560-3	1997	As was seen for the cytochrome P450 (cyp1A1) gene, aldh3 is transcriptionally inducible by polycyclic aromatic hydrocarbons (PAH), and this induction involving function of the arylhydrocarbon (Ah) receptor is inhibited by the protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine di-HCl (H7) and staurosporine.	Staurosporine	323-336	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	20-43
9013560-3	1997	As was seen for the cytochrome P450 (cyp1A1) gene, aldh3 is transcriptionally inducible by polycyclic aromatic hydrocarbons (PAH), and this induction involving function of the arylhydrocarbon (Ah) receptor is inhibited by the protein kinase C (PKC) inhibitors, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine di-HCl (H7) and staurosporine.	Staurosporine	323-336	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	51-56
9124324-7	1997	Staurosporine, an inhibitor for protein kinases that suppressed the TPA-induced IL-6 synthesis, significantly inhibited the PGF2alpha-induced IL-6 synthesis.	Staurosporine	0-13	interleukin 6	Mus musculus	80-84
9124324-7	1997	Staurosporine, an inhibitor for protein kinases that suppressed the TPA-induced IL-6 synthesis, significantly inhibited the PGF2alpha-induced IL-6 synthesis.	Staurosporine	0-13	interleukin 6	Mus musculus	142-146
9071558-4	1997	However, staurosporine enhanced cytotoxicity by TNF in the presence of actinomycin D, a protein synthesis inhibitor.	Staurosporine	9-22	tumor necrosis factor	Mus musculus	48-51
9071558-5	1997	In view of this finding, the authors investigated the role of specific PKC isozymes in both TNF-mediated cytotoxicity and staurosporine-induced sensitization to killing.	Staurosporine	122-135	protein kinase C, alpha	Mus musculus	71-74
9071558-10	1997	Staurosporine caused a translocation of PKC-zeta to the plasma membrane and a loss of PKC-epsilon from the cytosol.	Staurosporine	0-13	protein kinase C, epsilon	Mus musculus	86-97
9071558-13	1997	These findings suggest the possibility that the mechanism by which staurosporine potentiates TNF action does not involve inhibition of PKC, but in contrast may involve modulation of PKC-zeta.	Staurosporine	67-80	tumor necrosis factor	Mus musculus	93-96
9024297-5	1997	RESULTS: The general protein kinase inhibitors staurosporine and H-8 inhibited rat cGK II activity in vitro with 50% inhibitory concentration values of 4 nmol/L and 3 mumol/L, respectively, which are lower than those reported for cAK.	Staurosporine	47-60	protein kinase cGMP-dependent 2	Rattus norvegicus	83-89
9024297-5	1997	RESULTS: The general protein kinase inhibitors staurosporine and H-8 inhibited rat cGK II activity in vitro with 50% inhibitory concentration values of 4 nmol/L and 3 mumol/L, respectively, which are lower than those reported for cAK.	Staurosporine	47-60	cyclin-dependent kinase 7	Rattus norvegicus	230-233
9023325-7	1997	In contrast, TNF-alpha production in response to okadaic acid was inhibited by the TNF-converting enzyme inhibitor GI 129471 and staurosporin but was unaffected by either IL-1ra, dexamethasone or NS-398.	Staurosporine	129-141	tumor necrosis factor	Homo sapiens	13-22
9009149-4	1997	Transient exposure of UEC to agents that inhibit tyrosine kinases by distinct mechanisms, i.e., tyrphostin, genistein, and staurosporine, consistently and significantly reduced Muc-1 expression.	Staurosporine	123-136	mucin 1, transmembrane	Mus musculus	177-182
9039645-8	1997	Among the PKC inhibitors tested, staurosporine (STA)-but not calphostin C (CALP)-abolished the effect of IFN-gamma and of PMA and antagonized only partially that of co-applied IFN-gamma and PMA.	Staurosporine	33-46	protein kinase C, gamma	Rattus norvegicus	10-13
9039645-8	1997	Among the PKC inhibitors tested, staurosporine (STA)-but not calphostin C (CALP)-abolished the effect of IFN-gamma and of PMA and antagonized only partially that of co-applied IFN-gamma and PMA.	Staurosporine	33-46	interferon gamma	Rattus norvegicus	105-114
9130145-2	1997	Using primary culture methods, we report that neurons and astrocytes require the activity of the ICE/CED-3 family of proteases to undergo apoptosis induced by staurosporine, ceramide, and serum-free media.	Staurosporine	159-172	caspase 1	Homo sapiens	97-100
9130145-2	1997	Using primary culture methods, we report that neurons and astrocytes require the activity of the ICE/CED-3 family of proteases to undergo apoptosis induced by staurosporine, ceramide, and serum-free media.	Staurosporine	159-172	intraflagellar transport 43	Homo sapiens	101-106
9059991-7	1997	Exposure of HSF1 gene-transfected cells to heat resulted in a transient but significant increase in HSP-70 gene expression as compared to that found in vector-transfected cells, which was completely inhibited by treatment with staurosporine.	Staurosporine	227-240	heat shock transcription factor 1	Homo sapiens	12-16
9059991-7	1997	Exposure of HSF1 gene-transfected cells to heat resulted in a transient but significant increase in HSP-70 gene expression as compared to that found in vector-transfected cells, which was completely inhibited by treatment with staurosporine.	Staurosporine	227-240	heat shock protein family A (Hsp70) member 4	Homo sapiens	100-106
9203625-9	1997	This finding is corroborated by the use of staurosporine, a nonselective PKC inhibitor, that prevented the effect of TPA.	Staurosporine	43-56	protein kinase C alpha	Homo sapiens	73-76
9039645-8	1997	Among the PKC inhibitors tested, staurosporine (STA)-but not calphostin C (CALP)-abolished the effect of IFN-gamma and of PMA and antagonized only partially that of co-applied IFN-gamma and PMA.	Staurosporine	33-46	interferon gamma	Rattus norvegicus	176-185
9039645-8	1997	Among the PKC inhibitors tested, staurosporine (STA)-but not calphostin C (CALP)-abolished the effect of IFN-gamma and of PMA and antagonized only partially that of co-applied IFN-gamma and PMA.	Staurosporine	48-51	protein kinase C, gamma	Rattus norvegicus	10-13
9039645-8	1997	Among the PKC inhibitors tested, staurosporine (STA)-but not calphostin C (CALP)-abolished the effect of IFN-gamma and of PMA and antagonized only partially that of co-applied IFN-gamma and PMA.	Staurosporine	48-51	interferon gamma	Rattus norvegicus	105-114
9039645-8	1997	Among the PKC inhibitors tested, staurosporine (STA)-but not calphostin C (CALP)-abolished the effect of IFN-gamma and of PMA and antagonized only partially that of co-applied IFN-gamma and PMA.	Staurosporine	48-51	interferon gamma	Rattus norvegicus	176-185
8999958-8	1997	Furthermore, both 12-O-tetradecanoylphorbol 13-acetate and a nonspecific kinase inhibitor, staurosporine, prevented ceramide-induced apoptosis by inhibiting cytosolic translocation of PKC-delta and -epsilon.	Staurosporine	91-104	protein kinase C epsilon	Homo sapiens	184-206
8972707-8	1996	These results indicate the involvement of Ca2+/calmodulin-dependent staurosporine/polymyxin B-sensitive protein kinase other than protein kinase C in swelling-induced activation of Na+,K+,2Cl- cotransport in glial cells.	Staurosporine	68-81	calmodulin 1	Homo sapiens	47-57
9037258-0	1997	Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation.	Staurosporine	42-55	ATP binding cassette subfamily B member 1	Homo sapiens	107-121
9547581-7	1997	In contrast, the potent PKC inhibitor staurosporine was inactive against LTB4 in these studies (&lt; 23% inhibition at 10 microM, n = 2), but inhibited ROI formation (IC50 approximately 3nM).	Staurosporine	38-51	proline rich transmembrane protein 2	Homo sapiens	24-27
9008246-7	1997	Long-term exposure of both types of cells to the PKC inhibitor staurosporine (0.1 micromol/L) reduced both basal endothelin-1 release and the enhancement of release by PMA or OAG.	Staurosporine	63-76	endothelin 1	Homo sapiens	113-125
9038829-5	1997	Staurosporine [protein kinase C (PKC) inhibitor] selectively reduced Na(+)-K(+)-Cl- cotransport, whereas verapamil but not nifedipine (L-type voltage-dependent Ca2+ channel blockers) decreased Na(+)-K(+)-ATPase activity induced by ET-1.	Staurosporine	0-13	endothelin 1	Homo sapiens	231-235
9021050-5	1997	This down-regulation of CD4 was inhibited in a dose-dependent manner by the protein kinase C (PKC) antagonist, staurosporine.	Staurosporine	111-124	CD4 molecule	Homo sapiens	24-27
9147607-4	1997	Staurosporine, an alkaloid isolated from microbial sources, is ine of the most potent PKC inhibitors and has shown high antiproliferative activity in vitro, but poor selectivity.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	86-89
9147607-5	1997	Staurosporine analogs have thus been synthesize with the aim of obtaining more selective PKC inhibition; among these, CGP 41251 has shown reduced PKC inhibitory activity, but a higher degree of selectivity when assayed for inhibition of different kinases.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	89-92
9227836-8	1997	Nevertheless, the percentage of calcium-independent CaM-kinase II activity in the CA3 area was suppressed by EGTA, nitrendipine, KN-62, staurosporin, or H-89, indicating that the activity of CaM-kinase II in the CA3 area was independent of NMDA receptor activation.	Staurosporine	136-148	carbonic anhydrase 3	Rattus norvegicus	82-85
9254022-11	1997	On the basis that apoptosis and neurotrophin independence are hallmarks of the maturation of dorsal root ganglion neurons, results suggest that staurosporine-differentiated SH-SY5Y cells may bear a similar phenotype to that found in vivo.	Staurosporine	144-157	brain derived neurotrophic factor	Homo sapiens	32-44
9054953-8	1997	Etoposide-induced apoptosis, and its potentiation by staurosporine, were associated with reduced c-myc expression, and a moderate increase in p21WAF1/CIP1 mRNA and protein levels.	Staurosporine	53-66	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	97-102
9054953-12	1997	CONCLUSION: These results indicate that staurosporine potentiates apoptosis through events which occur downstream of DNA damage, and implicate unscheduled activation of cyclin A-dependent kinase during inhibition of DNA synthesis as a possible cause.	Staurosporine	40-53	cyclin A2	Homo sapiens	169-177
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	caspase 3	Homo sapiens	32-36
16465208-0	1997	Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis.	Staurosporine	123-136	BCL2 apoptosis regulator	Homo sapiens	0-5
16465208-0	1997	Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis.	Staurosporine	123-136	caspase 3	Homo sapiens	29-34
16465208-0	1997	Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis.	Staurosporine	123-136	poly(ADP-ribose) polymerase 1	Homo sapiens	69-97
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	caspase 3	Homo sapiens	26-31
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	caspase 3	Homo sapiens	37-44
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	carboxylesterase 2	Homo sapiens	62-65
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	intraflagellar transport 43	Homo sapiens	66-71
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	caspase 3	Homo sapiens	177-182
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	poly(ADP-ribose) polymerase 1	Homo sapiens	215-243
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	poly(ADP-ribose) polymerase 1	Homo sapiens	245-249
16465208-6	1997	Here, we demonstrate that CPP32/Yama/Apopain, a member of the ICE/Ced-3 gene family, is processed during staurosporine-induced apoptosis in HeLa cells and that concomitant with CPP32 activation, two other proteins, poly (ADP-ribose) polymerase (PARP) and the U1-70 K small ribonucleoprotein, also undergo proteolysis.	Staurosporine	105-118	small nuclear ribonucleoprotein U1 subunit 70	Homo sapiens	259-266
9237043-6	1997	In order to test whether the differential regulation of c-jun gene was caused by the differential activation (or inactivation) of the AP-1 transcription factor, the DNA-binding activity of this transcription factor in staurosporine-treated cells was measured.	Staurosporine	218-231	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	134-138
9237043-7	1997	Gelshift analysis with a synthetic oligonucleotide probe showed modest effects of staurosporine on the DNA-binding activity of the transcription factor AP-1.	Staurosporine	82-95	Jun proto-oncogene, AP-1 transcription factor subunit	Bos taurus	152-156
8978352-9	1997	The stimulatory effect of TNF-alpha (10 ng/mL) was potentiated by the addition of IL-8 (1 nmol/L), inhibited by octreotide and staurosporine, but unaffected by indomethacin.	Staurosporine	127-140	tumor necrosis factor	Canis lupus familiaris	26-35
8978352-9	1997	The stimulatory effect of TNF-alpha (10 ng/mL) was potentiated by the addition of IL-8 (1 nmol/L), inhibited by octreotide and staurosporine, but unaffected by indomethacin.	Staurosporine	127-140	C-X-C motif chemokine ligand 8	Canis lupus familiaris	82-86
9011567-12	1997	The PMA-induced increase in HSP-72 protein peaked 8 h after treatment with PMA and returned to baseline levels at 72 h. This increase was blocked by a PKC inhibitor, staurosporine.	Staurosporine	166-179	heat shock protein family A (Hsp70) member 1A	Homo sapiens	28-34
9034963-6	1997	Staurosporine (STS) inhibited PKC at 200-500 nM but stimulated PLD activity 2-fold at &gt; or = 1 microM.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	30-33
8978729-7	1997	Parallels between the time course, concentration dependency, and staurosporine sensitivity of alterations in transporter phosphorylation and transporter Vmax suggest that dopamine transporter phosphorylation involving PKC could contribute to this decreased transporter function.	Staurosporine	65-78	protein kinase C, gamma	Rattus norvegicus	218-221
8987735-6	1997	Biotinylation/immunoblot analyses showed that activity reductions are paralleled by a staurosporine-sensitive loss of surface SERT protein.	Staurosporine	86-99	solute carrier family 6 member 4	Homo sapiens	126-130
9641816-4	1997	For hGHR degradation, however, staurosporine-sensitive phosphorylation is necessary.	Staurosporine	31-44	growth hormone receptor	Homo sapiens	4-8
9496375-0	1997	The microbial alkaloid toxin staurosporine blocks the phorbol ester-induced increase in beta-amyloid precursor protein in PC12 cells.	Staurosporine	29-42	amyloid beta precursor protein	Rattus norvegicus	88-118
9392849-0	1997	Staurosporine-dependent activation of human endothelial cell monolayers for neutrophil adherence by secretoneurin.	Staurosporine	0-13	secretogranin II	Homo sapiens	100-113
9064647-4	1997	Addition of PKC inhibitors, i. e. staurosporine (0.2-20 microM), bisindolylmaleimide (1 microM) or chelerythrine (1 microM), irreversibly suppressed thrombin-induced [Ca2+]i oscillations.	Staurosporine	34-47	coagulation factor II	Rattus norvegicus	149-157
9064647-7	1997	The amount of Ca2+ released by t-BuBHQ, which was normalized by comparison with the thrombin-induced Ca2+ response, was decreased by simultaneous incubation with staurosporine or chelerythrine, but enhanced with the PKC activator oleoyl acetyl glycerol.	Staurosporine	162-175	coagulation factor II	Rattus norvegicus	84-92
8954978-4	1996	Protein kinase C (PKC) inhibitor staurosporine inhibited ETs-induced ICAM-1 expression on both cell types.	Staurosporine	33-46	intercellular adhesion molecule 1	Rattus norvegicus	69-75
9003773-3	1996	Here we show that the C-terminal 42 amino acid peptide of the retinoblastoma (Rb) protein, an important cell cycle regulator with a known anti-apoptotic function, is specifically cleaved off by an ICE-like protease in tumour necrosis factor (TNF)- and staurosporine-induced apoptosis.	Staurosporine	252-265	RB transcriptional corepressor 1	Homo sapiens	62-76
9003773-3	1996	Here we show that the C-terminal 42 amino acid peptide of the retinoblastoma (Rb) protein, an important cell cycle regulator with a known anti-apoptotic function, is specifically cleaved off by an ICE-like protease in tumour necrosis factor (TNF)- and staurosporine-induced apoptosis.	Staurosporine	252-265	RB transcriptional corepressor 1	Homo sapiens	78-80
9003773-3	1996	Here we show that the C-terminal 42 amino acid peptide of the retinoblastoma (Rb) protein, an important cell cycle regulator with a known anti-apoptotic function, is specifically cleaved off by an ICE-like protease in tumour necrosis factor (TNF)- and staurosporine-induced apoptosis.	Staurosporine	252-265	tumor necrosis factor	Homo sapiens	218-240
9003773-3	1996	Here we show that the C-terminal 42 amino acid peptide of the retinoblastoma (Rb) protein, an important cell cycle regulator with a known anti-apoptotic function, is specifically cleaved off by an ICE-like protease in tumour necrosis factor (TNF)- and staurosporine-induced apoptosis.	Staurosporine	252-265	tumor necrosis factor	Homo sapiens	242-245
8954916-5	1996	Pretreatment of platelets with staurosporine, a potent protein kinase inhibitor, diminished LPA-induced Syk phosphorylation and activation, but not intracellular Ca2+ mobilization.	Staurosporine	31-44	spleen associated tyrosine kinase	Homo sapiens	104-107
8968108-6	1996	Induction was also inhibited by cytochalasin D, staurosporine, or dexamethasone, suggesting the need, respectively, for an organized actin cytoskeleton, protein kinase C, and AP-1-driven gene transcription.	Staurosporine	48-61	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	175-179
9013943-10	1997	Incubation with the tyrosine kinase inhibitor genistein, and, to a lesser extent, with the protein kinase C inhibitor staurosporine, resulted in decreased pp125 FAK phosphorylation.	Staurosporine	118-131	protein tyrosine kinase 2	Homo sapiens	161-164
8943287-6	1996	In parental MCF-7 cells, PKC inhibitors (GF109203X (bisindolylmaleimide I) and staurosporine) reduced IRS-1 content.	Staurosporine	79-92	protein kinase C alpha	Homo sapiens	25-28
8943287-6	1996	In parental MCF-7 cells, PKC inhibitors (GF109203X (bisindolylmaleimide I) and staurosporine) reduced IRS-1 content.	Staurosporine	79-92	insulin receptor substrate 1	Homo sapiens	102-107
8986134-11	1996	Staurosporine, but not GF 109203X, prevented the induction of the casein gene by prolactin.	Staurosporine	0-13	prolactin	Oryctolagus cuniculus	81-90
8986134-15	1996	GF 109203X, but not staurosporine, inhibited PKC activity, whereas staurosporine but not GF 109203X, inhibited the induction of Nb2 cell multiplication and the accumulation of c-myc, beta-actin and stathmin mRNAs.	Staurosporine	67-80	myc proto-oncogene protein	Oryctolagus cuniculus	176-181
8969274-8	1996	IL-8 secretion was also suppressed by staurosporine, an inhibitor of protein kinase C, and by inhibitors of tyrosine kinase such as herbimycin A and genistein.	Staurosporine	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
8969274-10	1996	Taken together, the results suggest that asbestos-induced redox changes and phosphorylation events, mediated by staurosporine-sensitive and tyrosine kinase(s), activate nuclear proteins which recognize the NF-kappaB/NF-IL-6 binding sites of the IL-8 promoter and contribute to the regulation of IL-8 gene expression.	Staurosporine	112-125	CCAAT enhancer binding protein beta	Homo sapiens	216-223
8969274-10	1996	Taken together, the results suggest that asbestos-induced redox changes and phosphorylation events, mediated by staurosporine-sensitive and tyrosine kinase(s), activate nuclear proteins which recognize the NF-kappaB/NF-IL-6 binding sites of the IL-8 promoter and contribute to the regulation of IL-8 gene expression.	Staurosporine	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	245-249
8969274-10	1996	Taken together, the results suggest that asbestos-induced redox changes and phosphorylation events, mediated by staurosporine-sensitive and tyrosine kinase(s), activate nuclear proteins which recognize the NF-kappaB/NF-IL-6 binding sites of the IL-8 promoter and contribute to the regulation of IL-8 gene expression.	Staurosporine	112-125	C-X-C motif chemokine ligand 8	Homo sapiens	295-299
8997387-7	1996	In contrast preincubation with staurosporine completely obliterated the PTH-induced calcium efflux.	Staurosporine	31-44	parathyroid hormone	Homo sapiens	72-75
8940366-3	1996	Also, inhibitors of protein kinase C, staurosporine and calphostin C, reduced the AVP-induced increase in phosphatidylethanol.	Staurosporine	38-51	arginine vasopressin	Rattus norvegicus	82-85
9035611-10	1996	Inhibition of PKC activity by PKC inhibitors (H-7 or staurosporine) or downregulation induced by prolonged treatment with phorbol 12-myristate 13-acetate (PMA) or thyleametoxin (TX) significantly blocked the NE-induced AA release, which indicates PKC is involved in mediating NE-induced AA release.	Staurosporine	53-66	protein kinase C, alpha	Rattus norvegicus	14-17
8980909-5	1996	The PKC inhibitors (H7, calphostin C, and staurosporine) inhibited TNF-induced uPA expression and secretion in a dose-dependent manner.	Staurosporine	42-55	tumor necrosis factor	Homo sapiens	67-70
8980909-5	1996	The PKC inhibitors (H7, calphostin C, and staurosporine) inhibited TNF-induced uPA expression and secretion in a dose-dependent manner.	Staurosporine	42-55	plasminogen activator, urokinase	Homo sapiens	79-82
8947493-8	1996	In addition, low doses of staurosporine inhibited ERK1 activation by LPA.	Staurosporine	26-39	mitogen activated protein kinase 3	Rattus norvegicus	50-54
8947049-1	1996	After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment.	Staurosporine	280-293	interferon gamma	Homo sapiens	6-22
8947049-1	1996	After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment.	Staurosporine	280-293	interferon gamma	Homo sapiens	24-33
8947049-1	1996	After interferon-gamma (IFN-gamma) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 min, remained for 2-2.5 h and activated molecules disappeared by 4 h. In the absence of continued signaling from the receptor (imposed by staurosporine treatment) previously activated Stat1 disappeared completely within 60 min, implying continuous generation and removal of active molecules during extended IFN-gamma treatment.	Staurosporine	280-293	signal transducer and activator of transcription 1	Homo sapiens	96-101
8937450-4	1996	At high concentration, staurosporine, a nonselective inhibitor of protein kinases, induced the production of short neurites and mimicked the protein-kinase-A-dependent effect on tPA release.	Staurosporine	23-36	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	141-157
8910508-7	1996	Staurosporine blocked cross-phosphorylation and cross-desensitization of the PAFR by peptide chemoattractants.	Staurosporine	0-13	platelet-activating factor receptor	Rattus norvegicus	77-81
8941712-3	1996	Overexpression of PS-2 conferred increased sensitivity to the apoptotic stimuli staurosporine and hydrogen peroxide.	Staurosporine	80-93	presenilin 2	Mus musculus	18-22
8914015-7	1996	Low dose Ang II-induced increase in dpHi/dt was not affected by preincubation with a specific PKA inhibitor, Rp-CPT-cAMP 10(-4) M, and was completely abolished by preincubation with PKC inhibitors, staurosporine 10(-7) M, sphingosine 5.10(-6) M, or calphostin 10(-6) M. In addition, pretreatment of rats with pertussis toxin led to a partial inhibition of the effect of low dose Ang II.	Staurosporine	198-211	angiotensinogen	Rattus norvegicus	9-15
9023013-9	1996	Furthermore, basic fibroblast growth factor stimulated arachidonic acid release was also inhibited by 10 microM U73122 and by 100 nM staurosporine, phospholipase C and protein kinase C respective inhibitors.	Staurosporine	133-146	fibroblast growth factor 2	Rattus norvegicus	13-43
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	31-44	intercellular adhesion molecule 1	Homo sapiens	72-105
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	31-44	interferon gamma	Homo sapiens	314-360
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	31-44	interleukin 1 alpha	Homo sapiens	366-379
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	249-262	intercellular adhesion molecule 1	Homo sapiens	72-105
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	249-262	interferon gamma	Homo sapiens	314-360
8938544-8	1996	The protein kinase C inhibitor staurosporine abrogated the induction of intercellular adhesion molecule-1 by phorbol 12-myristate 13-acetate, indicating that this effect was indeed exerted by protein kinase C. More original was our observation that staurosporine also completely blocked the stimulatory effects of interferon-gamma, tumour necrosis factor-alpha, and interleukin-1.	Staurosporine	249-262	interleukin 1 alpha	Homo sapiens	366-379
8958700-5	1996	ET-1 stimulated type IV collagen production in a dose-dependent fashion, and this effect was blocked by the protein kinase C inhibitor, staurosporine.	Staurosporine	136-149	endothelin 1	Rattus norvegicus	0-4
8908158-5	1996	Staurosporine and calphostin C, protein kinase C (PKC) inhibitors, blocked the increased in sphingosine kinase activity, suggesting a PKC-dependent regulation.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	50-53
8960146-7	1996	Exposure to staurosporine and UCN-01 for 72 h each suppressed the level of expression and altered the ratio of phosphorylated/dephosphorylated RB protein (ppRB/pRB) of Ma-31 cells.	Staurosporine	12-25	RB transcriptional corepressor 1	Homo sapiens	156-159
8960146-9	1996	A time course study demonstrated that exposure to the IC50 concentration of staurosporine for 48-72 h increased the ratio of ppRB/ pRB of Ma-31 cells, while exposure to the IC50 concentration of UCN-01 decreased that ratio.	Staurosporine	76-89	RB transcriptional corepressor 1	Homo sapiens	126-129
8948030-6	1996	Concentrations of hydroquinone (1-6 microM) that induce differentiation in 32D myeloblasts caused a concentration-dependent inhibition of staurosporine-induced apoptosis in both cell lines, with a 50% inhibitory concentration of 3 microM, and prevented apoptosis in IL-3-deprived 32D cells.	Staurosporine	138-151	interleukin 3	Mus musculus	266-270
8908158-5	1996	Staurosporine and calphostin C, protein kinase C (PKC) inhibitors, blocked the increased in sphingosine kinase activity, suggesting a PKC-dependent regulation.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	134-137
8798786-1	1996	We demonstrate that the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) is specifically, proteolytically cleaved in HL-60 cells treated with staurosporine (STS), a potent inducer of apoptosis.	Staurosporine	158-171	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	79-87
8798786-1	1996	We demonstrate that the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) is specifically, proteolytically cleaved in HL-60 cells treated with staurosporine (STS), a potent inducer of apoptosis.	Staurosporine	173-176	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	79-87
9081434-0	1996	[Modulation with phorbol myristate acetate and staurosporine  of interleukin 2- induced proliferation and nonspecific cytotoxicity of rat lymphocytes].	Staurosporine	47-60	interleukin 2	Rattus norvegicus	65-78
8943542-5	1996	Staurosporine significantly reduced oxytocin-stimulated contractile activity with mean activity reduced by &gt; 50% following the addition of 10(-6) M staurosporine (P &lt; 0.01), while addition of 10(-5) M resulted in a measured mean contractile activity of approximately 10% of the control (P &lt; 0.001, n = 5).	Staurosporine	0-13	oxytocin/neurophysin I prepropeptide	Homo sapiens	36-44
8891334-1	1996	The addition of 10 nM staurosporine (ST) to MDA 361 breast carcinoma cells induces a G1 arrest, which correlates with the loss of the catalytic activity of the G1-associated cyclin-dependent kinases (cdks) and increased levels of underphosphorylated retinoblastoma protein.	Staurosporine	22-35	cyclin dependent kinase 2	Homo sapiens	200-204
8891334-1	1996	The addition of 10 nM staurosporine (ST) to MDA 361 breast carcinoma cells induces a G1 arrest, which correlates with the loss of the catalytic activity of the G1-associated cyclin-dependent kinases (cdks) and increased levels of underphosphorylated retinoblastoma protein.	Staurosporine	37-39	cyclin dependent kinase 2	Homo sapiens	200-204
8828483-9	1996	Staurosporine, an inhibitor of protein kinase C, also significantly reduced the effects of bFGF and TGF alpha.	Staurosporine	0-13	fibroblast growth factor 2	Rattus norvegicus	91-95
8828483-9	1996	Staurosporine, an inhibitor of protein kinase C, also significantly reduced the effects of bFGF and TGF alpha.	Staurosporine	0-13	transforming growth factor alpha	Rattus norvegicus	100-109
8943542-5	1996	Staurosporine significantly reduced oxytocin-stimulated contractile activity with mean activity reduced by &gt; 50% following the addition of 10(-6) M staurosporine (P &lt; 0.01), while addition of 10(-5) M resulted in a measured mean contractile activity of approximately 10% of the control (P &lt; 0.001, n = 5).	Staurosporine	151-164	oxytocin/neurophysin I prepropeptide	Homo sapiens	36-44
8855796-9	1996	The increase of 3H-choline in slices" supernatant and the decrease of 3H-choline-labeled PtdCho induced by PDBu, ATP, thapsigargin, and STSP indicate that the activated PLD hydrolyzed PtdCho.	Staurosporine	136-140	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	169-172
8823363-9	1996	As expected, staurosporine and genistein inhibited, whereas okadaic acid augmented, the induction of K17 by IFN gamma.	Staurosporine	13-26	keratin 17	Homo sapiens	101-104
8823363-9	1996	As expected, staurosporine and genistein inhibited, whereas okadaic acid augmented, the induction of K17 by IFN gamma.	Staurosporine	13-26	interferon gamma	Homo sapiens	108-117
9772351-5	1996	In contrast, PKC inhibitor staurosporine significantly inhibited the occurrence of acrosome reaction.	Staurosporine	27-40	Prkca	Cavia porcellus	13-16
8910214-7	1996	The inhibitory effect of secretin and ACh could be relieved by atropine, and by the protein kinase C (PKC) inhibitors staurosporine and 1-(5-isoquinolinylsulphonyl)-2-methyl-piperazine (H-7).	Staurosporine	118-131	acyl-CoA thioesterase 12	Rattus norvegicus	38-41
9239689-6	1996	The results showed that addition of genistein or staurosporine (a tyrosine kinase and protein kinase-C antagonist respectively) to cultured granulosa cells resulted in potent inhibition of hPRL actions upon hFSH-induced aromatization in a dose-dependent manner.	Staurosporine	49-62	prolactin	Homo sapiens	189-193
8844973-5	1996	However, inhibition of protein kinases with staurosporin and calphostin C reduced c-fos by 80% in NRK-52E but by only 10-20% in H/1.2NRK.52E.	Staurosporine	44-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	82-87
8795621-3	1996	We investigated the activation of ICE/CED-3 proteases induced by three apoptotic stimuli (staurosporine, ceramide, and serum withdrawal) in the neuronal cell line GT1-7 and in cells overexpressing Bcl-2.	Staurosporine	90-103	caspase 1	Mus musculus	34-37
8804438-14	1996	Inhibition of PKC with H-7 or staurosporin increased pH(i).	Staurosporine	30-42	glucose-6-phosphate isomerase	Homo sapiens	53-58
8853338-5	1996	PMA-induced downregulation of SERCA2 mRNA levels was blocked by either 10 nM staurosporine or 4 microM chelerythrine, whereas treatment with either agent alone increased SERCA2 mRNA levels as compared with control cells.	Staurosporine	77-90	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	30-36
8816854-7	1996	Further work demonstrated that: (i) maximum production of both inflammatory mediators required a hydrolyzable form of ATP; (ii) blocking phosphorylation with staurosporin inhibited production of both; (iii) the reducing agent, dithiotreitol, had little affect on LTB4 formation but slightly enhanced PAF generation.	Staurosporine	158-170	PCNA clamp associated factor	Homo sapiens	300-303
8879350-2	1996	The PKC inhibitors staurosporine and H-7 did not affect basal CNP release, but each abolished the increase in CNP release induced by PMA or OAG.	Staurosporine	19-32	natriuretic peptide C	Homo sapiens	110-113
8843717-10	1996	The protein kinase C (PKC) inhibitors, staurosporine (1 microM) and chelerythrine chloride (2.5 microM), inhibited ET-1-evoked AA release by 70%.	Staurosporine	39-52	endothelin 1	Homo sapiens	115-119
8753839-6	1996	KT5926, an inhibitor of myosin light chain kinase, also inhibited histamine release in response to MCP-1 with an IC50 of 10(-6) M. Staurosporine, a potent inhibitor of protein kinase C, although being not specific, augmented MCP-1-induced histamine release by 31.9% at 10(-6) M. These results indicate the possible involvement of a series of kinases, including PI-3 kinase, in the signal transduction pathway used by MCP-1.	Staurosporine	131-144	C-C motif chemokine ligand 2	Homo sapiens	99-104
8872607-7	1996	In addition, staurosporine induced the tyrosine phosphorylation of the focal adhesion kinase p125FAK.	Staurosporine	13-26	protein tyrosine kinase 2	Rattus norvegicus	93-100
8882168-5	1996	The ANP secretory and chronotrophic effects of relaxin appear to involve the activation of protein kinase C, since administration of a protein kinase C inhibitor staurosporine at a concentration of 30 nM completely blocked the effect of relaxin (10 nM) on IR-ANP secretion (P &lt; 0.001) and heart rate (P &lt; 0.001).	Staurosporine	162-175	natriuretic peptide A	Rattus norvegicus	4-7
8882168-5	1996	The ANP secretory and chronotrophic effects of relaxin appear to involve the activation of protein kinase C, since administration of a protein kinase C inhibitor staurosporine at a concentration of 30 nM completely blocked the effect of relaxin (10 nM) on IR-ANP secretion (P &lt; 0.001) and heart rate (P &lt; 0.001).	Staurosporine	162-175	natriuretic peptide A	Homo sapiens	259-262
8875488-12	1996	In contrast to the effects of TPA, the PKC inhibitor staurosporine tended to reduce GH secretion, although this effect was not observed in all tumors examined.	Staurosporine	53-66	proline rich transmembrane protein 2	Homo sapiens	39-42
8875488-12	1996	In contrast to the effects of TPA, the PKC inhibitor staurosporine tended to reduce GH secretion, although this effect was not observed in all tumors examined.	Staurosporine	53-66	growth hormone 1	Homo sapiens	84-86
8795717-6	1996	Similarly, the phorbol ester PDBu, potentially stimulating protein phosphatase-1 and staurosporine, an inhibitor of serine/threonine kinases, enhanced adhesion to VCAM-1 as has previously been shown for ICAM-1.	Staurosporine	85-98	vascular cell adhesion molecule 1	Homo sapiens	163-169
8795717-6	1996	Similarly, the phorbol ester PDBu, potentially stimulating protein phosphatase-1 and staurosporine, an inhibitor of serine/threonine kinases, enhanced adhesion to VCAM-1 as has previously been shown for ICAM-1.	Staurosporine	85-98	intercellular adhesion molecule 1	Homo sapiens	203-209
8784137-14	1996	In vitro, a 24-hour pretreatment of the cultured hippocampal neurons with TGF-beta 1 (0.1 to 10 ng/mL) significantly inhibited both nitric oxide and staurosporine neurotoxicity.	Staurosporine	149-162	transforming growth factor, beta 1	Rattus norvegicus	74-84
8784137-15	1996	Posttreatment with TGF-beta 1 (10 ng/mL) also inhibited staurosporine neurotoxicity but actually potentiated nitric oxide-induced neuronal injury.	Staurosporine	56-69	transforming growth factor, beta 1	Rattus norvegicus	19-29
8772178-3	1996	Among the staurosporine-derived, rather selective PKC inhibitors the indolocarbazole Go 6976 previously shown to inhibit preferentially cPKC isotypes proved to be a potent inhibitor of PKC mu with an IC50 of 20 nM, whereas the bisindolylmaleimide Go 6983 was extremely ineffective in suppressing PKC mu kinase activity with a thousand-fold higher IC50 of 20 microM.	Staurosporine	10-23	protein kinase D1	Homo sapiens	185-191
8772178-3	1996	Among the staurosporine-derived, rather selective PKC inhibitors the indolocarbazole Go 6976 previously shown to inhibit preferentially cPKC isotypes proved to be a potent inhibitor of PKC mu with an IC50 of 20 nM, whereas the bisindolylmaleimide Go 6983 was extremely ineffective in suppressing PKC mu kinase activity with a thousand-fold higher IC50 of 20 microM.	Staurosporine	10-23	protein kinase D1	Homo sapiens	296-302
8772178-4	1996	Other strong inhibitors of PKC mu were the rather unspecific inhibitors staurosporine and K252a.	Staurosporine	72-85	protein kinase D1	Homo sapiens	27-33
8878121-4	1996	Staurosporine, an inhibitor of PKC, significantly decreased SN-induced chemotaxis of monocytes, suggesting that PKC may be involved in the signaling.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	31-34
8878121-4	1996	Staurosporine, an inhibitor of PKC, significantly decreased SN-induced chemotaxis of monocytes, suggesting that PKC may be involved in the signaling.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	112-115
8896792-1	1996	Parathyroid hormone (PTH) mobilises calcium in the hepatocyte, an effect which is abolished by verapamil and staurosporine.	Staurosporine	109-122	parathyroid hormone	Homo sapiens	0-19
8896792-1	1996	Parathyroid hormone (PTH) mobilises calcium in the hepatocyte, an effect which is abolished by verapamil and staurosporine.	Staurosporine	109-122	parathyroid hormone	Homo sapiens	21-24
8896792-6	1996	Verapamil and staurosporine also inhibited the PTH effect in dHGF-induced DNA synthesis.	Staurosporine	14-27	parathyroid hormone	Homo sapiens	47-50
8840026-0	1996	Long-term regulation of synapsin I gene expression and neuronal morphology by cyclic AMP and low-dose staurosporine.	Staurosporine	102-115	synapsin I	Homo sapiens	24-34
8840026-3	1996	Dopamine-beta hydroxylase mRNA was upregulated within 24 h. We provide evidence that low-dose staurosporine acts cooperatively with cyclic AMP in the acquisition of mature neuronal phenotypes.	Staurosporine	94-107	dopamine beta-hydroxylase	Homo sapiens	0-25
8864531-11	1996	The enhancing effect by CGRP on the depression of S2 was counteracted by staurosporine (3 nM), a protein kinase-C inhibitor, despite prolongation of the duration of non-contractile Ca2+ mobilization.	Staurosporine	73-86	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	24-28
8758926-7	1996	Nocodazole-arrested metaphase FT210 cells were pulsed with 100 ng/ml of staurosporine for 1 h. This 1-h treatment results in the inhibition of the mitotic p34(cdc2) kinase.	Staurosporine	72-85	alpha- and gamma-adaptin binding protein	Mus musculus	155-158
8758926-7	1996	Nocodazole-arrested metaphase FT210 cells were pulsed with 100 ng/ml of staurosporine for 1 h. This 1-h treatment results in the inhibition of the mitotic p34(cdc2) kinase.	Staurosporine	72-85	cyclin-dependent kinase 1	Mus musculus	159-163
8707377-13	1996	Moreover, the protein kinase C inhibitors GF109203X and staurosporine blocked U46619- and bFGF-induced increases in protein synthesis as well as active and total TGF-beta bioactivities.	Staurosporine	56-69	fibroblast growth factor 2	Rattus norvegicus	90-94
8707377-13	1996	Moreover, the protein kinase C inhibitors GF109203X and staurosporine blocked U46619- and bFGF-induced increases in protein synthesis as well as active and total TGF-beta bioactivities.	Staurosporine	56-69	transforming growth factor, beta 1	Rattus norvegicus	162-170
8872491-4	1996	With the addition of protein kinase C (PKC) inhibitors bisindolylmaleimide, staurosporine, H-7, or phloretin a reversal of the effect of IFN-gamma was noted whereas the addition of the cyclic nucleotide-dependent protein kinase inhibitors HA 1004, H-8, H-89, or cAMP-Dependent Protein Kinase (PKA) Inhibitor did not block the effect.	Staurosporine	76-89	interferon gamma	Homo sapiens	137-146
8764613-6	1996	Staurosporine, a protein kinase C (PKC) inhibitor, had no effect on Et-1-induced AA release but abolished that by phorbol 12-myristate 13-acetate, demonstrating that the Et-1 response was PKC independent.	Staurosporine	0-13	endothelin 1	Homo sapiens	170-174
8663336-4	1996	Staurosporine potentiated the effect of IL-1beta on coxII mRNA expression while calphostin C totally inhibited mRNA expression.	Staurosporine	0-13	interleukin 1 beta	Homo sapiens	40-48
8663336-6	1996	Furthermore, incubation of mesangial cells with IL-1beta causes translocation of PKCzeta from cytosol to a presumed membrane compartment, and this translocation phenomenon was not inhibited by incubating the cells with staurosporine but was inhibited with calphostin C. Gel retardation assays also demonstrated that staurosporine did not inhibit the IL-1beta-stimulated binding of nuclear extracts to the NFkappaB motif.	Staurosporine	219-232	interleukin 1 beta	Homo sapiens	48-56
8663336-6	1996	Furthermore, incubation of mesangial cells with IL-1beta causes translocation of PKCzeta from cytosol to a presumed membrane compartment, and this translocation phenomenon was not inhibited by incubating the cells with staurosporine but was inhibited with calphostin C. Gel retardation assays also demonstrated that staurosporine did not inhibit the IL-1beta-stimulated binding of nuclear extracts to the NFkappaB motif.	Staurosporine	316-329	interleukin 1 beta	Homo sapiens	48-56
8663336-6	1996	Furthermore, incubation of mesangial cells with IL-1beta causes translocation of PKCzeta from cytosol to a presumed membrane compartment, and this translocation phenomenon was not inhibited by incubating the cells with staurosporine but was inhibited with calphostin C. Gel retardation assays also demonstrated that staurosporine did not inhibit the IL-1beta-stimulated binding of nuclear extracts to the NFkappaB motif.	Staurosporine	316-329	protein kinase C zeta	Homo sapiens	81-88
8674178-7	1996	Bay K 8644 (an L-type Ca2+ channel agonist) also induced coronary spasm at the IL-1 beta-treated site, which was significantly inhibited by pretreatment with staurosporine, sphingosine, and nifedipine.	Staurosporine	158-171	interleukin-1 beta	Sus scrofa	79-88
8843032-5	1996	In agreement with this conclusion, it was found that the serotonin effect was inhibited by the protein kinase C inhibitors sphingosine (1 microM) or staurosporine (1 microM) added 20 min before NMDA application and by oocyte injection of protein kinase C (PKC)-inhibitor peptide (500 ng/oocyte) 1 hr prior to recordings.	Staurosporine	149-162	protein kinase C, gamma	Rattus norvegicus	238-254
8843032-5	1996	In agreement with this conclusion, it was found that the serotonin effect was inhibited by the protein kinase C inhibitors sphingosine (1 microM) or staurosporine (1 microM) added 20 min before NMDA application and by oocyte injection of protein kinase C (PKC)-inhibitor peptide (500 ng/oocyte) 1 hr prior to recordings.	Staurosporine	149-162	protein kinase C, gamma	Rattus norvegicus	256-259
8663100-7	1996	The MAPK and NHE activities induced by PMA were inhibited by staurosporine, a potent inhibitor for protein kinase C (PKC), and by MAPK kinase (MEK) inhibitor, PD98059, but were not affected by the tyrosine kinase inhibitor genistein.	Staurosporine	61-74	solute carrier family 9 member C1	Homo sapiens	13-16
8663291-7	1996	We also report that the expression of small stress proteins from different species, such as human hsp27, Drosophila Dhsp27, or human alphaB-crystallin, confers resistance to apoptotic cell death induced by staurosporine, a protein kinase C inhibitor.	Staurosporine	206-219	heat shock protein family B (small) member 1	Homo sapiens	98-103
8663291-7	1996	We also report that the expression of small stress proteins from different species, such as human hsp27, Drosophila Dhsp27, or human alphaB-crystallin, confers resistance to apoptotic cell death induced by staurosporine, a protein kinase C inhibitor.	Staurosporine	206-219	Heat shock protein 27	Drosophila melanogaster	116-122
8694782-0	1996	Decreased accumulation and dephosphorylation of the mitosis-specific form of nucleophosmin/B23 in staurosporine-induced chromosome decondensation.	Staurosporine	98-111	nucleophosmin 1	Homo sapiens	77-90
8694782-0	1996	Decreased accumulation and dephosphorylation of the mitosis-specific form of nucleophosmin/B23 in staurosporine-induced chromosome decondensation.	Staurosporine	98-111	nucleophosmin 1	Homo sapiens	91-94
8694782-2	1996	In the present study, the protein kinase inhibitor staurosporine has been used to examine possible changes in nucleophosmin/B23 at mitosis in HeLa cells.	Staurosporine	51-64	nucleophosmin 1	Homo sapiens	110-123
8694782-2	1996	In the present study, the protein kinase inhibitor staurosporine has been used to examine possible changes in nucleophosmin/B23 at mitosis in HeLa cells.	Staurosporine	51-64	nucleophosmin 1	Homo sapiens	124-127
8694782-3	1996	Addition of staurosporine to HeLa cells already arrested at mitosis by nocodazole causes: (i) decreased accumulation of the mitosis-specific form of nucleophosmin/B23, (ii) dephosphorylation of nucleophosmin/ B23, (iii) redistribution of nucleophosmin/B23 to the cytosol, and (iv) concomitant decondensation of chromosomes.	Staurosporine	12-25	nucleophosmin 1	Homo sapiens	149-162
8694782-3	1996	Addition of staurosporine to HeLa cells already arrested at mitosis by nocodazole causes: (i) decreased accumulation of the mitosis-specific form of nucleophosmin/B23, (ii) dephosphorylation of nucleophosmin/ B23, (iii) redistribution of nucleophosmin/B23 to the cytosol, and (iv) concomitant decondensation of chromosomes.	Staurosporine	12-25	nucleophosmin 1	Homo sapiens	163-166
8694782-3	1996	Addition of staurosporine to HeLa cells already arrested at mitosis by nocodazole causes: (i) decreased accumulation of the mitosis-specific form of nucleophosmin/B23, (ii) dephosphorylation of nucleophosmin/ B23, (iii) redistribution of nucleophosmin/B23 to the cytosol, and (iv) concomitant decondensation of chromosomes.	Staurosporine	12-25	nucleophosmin 1	Homo sapiens	194-207
8694782-3	1996	Addition of staurosporine to HeLa cells already arrested at mitosis by nocodazole causes: (i) decreased accumulation of the mitosis-specific form of nucleophosmin/B23, (ii) dephosphorylation of nucleophosmin/ B23, (iii) redistribution of nucleophosmin/B23 to the cytosol, and (iv) concomitant decondensation of chromosomes.	Staurosporine	12-25	nucleophosmin 1	Homo sapiens	209-212
8694782-3	1996	Addition of staurosporine to HeLa cells already arrested at mitosis by nocodazole causes: (i) decreased accumulation of the mitosis-specific form of nucleophosmin/B23, (ii) dephosphorylation of nucleophosmin/ B23, (iii) redistribution of nucleophosmin/B23 to the cytosol, and (iv) concomitant decondensation of chromosomes.	Staurosporine	12-25	nucleophosmin 1	Homo sapiens	194-207
8694782-3	1996	Addition of staurosporine to HeLa cells already arrested at mitosis by nocodazole causes: (i) decreased accumulation of the mitosis-specific form of nucleophosmin/B23, (ii) dephosphorylation of nucleophosmin/ B23, (iii) redistribution of nucleophosmin/B23 to the cytosol, and (iv) concomitant decondensation of chromosomes.	Staurosporine	12-25	nucleophosmin 1	Homo sapiens	209-212
8841932-10	1996	Protein kinase C (PKC) inhibitors staurosporine (15 nM) and bisindolylmaleimide I (0.5 microM) also blocked ET effect.	Staurosporine	34-47	protein kinase C, gamma	Rattus norvegicus	0-16
8898346-8	1996	This negative feed-back of PKC on GnRH-Induced PLC and PLA2 activities was reversed when PKC was either down regulated after long TPA treatments or inhibited by the PKC inhibitors, staurosporine or GF109203X.	Staurosporine	181-194	phospholipase A2 group IIA	Homo sapiens	55-59
8766002-4	1996	Staurosporine did not change EPO and VEGF mRNA levels at 20% O2, but in a concentration-dependent manner, decreased EPO and VEGF mRNA at 1% O2 with IC50 values of 30 nM and 1000 nM, respectively.	Staurosporine	0-13	erythropoietin	Rattus norvegicus	116-119
8766002-4	1996	Staurosporine did not change EPO and VEGF mRNA levels at 20% O2, but in a concentration-dependent manner, decreased EPO and VEGF mRNA at 1% O2 with IC50 values of 30 nM and 1000 nM, respectively.	Staurosporine	0-13	vascular endothelial growth factor A	Rattus norvegicus	124-128
8830854-3	1996	We report here that NRSF mRNA content was markedly decreased in a human neuroblastoma cell line following differentiation induced by staurosporine plus cyclic AMP, with a concomitant increase in mRNA levels of synapsin I, whose expression is restricted to neuronal cell types.	Staurosporine	133-146	RE1 silencing transcription factor	Homo sapiens	20-24
8660932-0	1996	BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine.	Staurosporine	120-133	apoptosis regulator Bcl-2	Cricetulus griseus	0-5
8660932-0	1996	BCL-2 and MCL-1 expression in Chinese hamster ovary cells inhibits intracellular acidification and apoptosis induced by staurosporine.	Staurosporine	120-133	induced myeloid leukemia cell differentiation protein Mcl-1	Cricetulus griseus	10-15
8650198-0	1996	G1 arrest and down-regulation of cyclin E/cyclin-dependent kinase 2 by the protein kinase inhibitor staurosporine are dependent on the retinoblastoma protein in the bladder carcinoma cell line 5637.	Staurosporine	100-113	cyclin dependent kinase 2	Homo sapiens	42-67
8650198-4	1996	52, 1968-1973], these cells, now pRB+, were arrested by staurosporine in G1 phase.	Staurosporine	56-69	RB transcriptional corepressor 1	Homo sapiens	33-36
8650198-6	1996	In both the pRB+ and pRB- cells, cyclin D1-associated kinase activities were reduced on staurosporine treatment.	Staurosporine	88-101	RB transcriptional corepressor 1	Homo sapiens	12-15
8650198-6	1996	In both the pRB+ and pRB- cells, cyclin D1-associated kinase activities were reduced on staurosporine treatment.	Staurosporine	88-101	RB transcriptional corepressor 1	Homo sapiens	21-24
8650198-6	1996	In both the pRB+ and pRB- cells, cyclin D1-associated kinase activities were reduced on staurosporine treatment.	Staurosporine	88-101	cyclin D1	Homo sapiens	33-42
8650198-9	1996	Immunoprecipitation of CDK2, cyclin E, and p2l from staurosporine-treated pRB+ cells revealed a 2.5- to 3-fold higher ratio of p2l bound to CDK2 compared with staurosporine-treated pRB- cells.	Staurosporine	52-65	cyclin dependent kinase 2	Homo sapiens	23-27
8650198-9	1996	Immunoprecipitation of CDK2, cyclin E, and p2l from staurosporine-treated pRB+ cells revealed a 2.5- to 3-fold higher ratio of p2l bound to CDK2 compared with staurosporine-treated pRB- cells.	Staurosporine	52-65	RB transcriptional corepressor 1	Homo sapiens	74-77
8650198-9	1996	Immunoprecipitation of CDK2, cyclin E, and p2l from staurosporine-treated pRB+ cells revealed a 2.5- to 3-fold higher ratio of p2l bound to CDK2 compared with staurosporine-treated pRB- cells.	Staurosporine	52-65	cyclin dependent kinase 2	Homo sapiens	140-144
8650198-9	1996	Immunoprecipitation of CDK2, cyclin E, and p2l from staurosporine-treated pRB+ cells revealed a 2.5- to 3-fold higher ratio of p2l bound to CDK2 compared with staurosporine-treated pRB- cells.	Staurosporine	52-65	RB transcriptional corepressor 1	Homo sapiens	181-184
8650198-9	1996	Immunoprecipitation of CDK2, cyclin E, and p2l from staurosporine-treated pRB+ cells revealed a 2.5- to 3-fold higher ratio of p2l bound to CDK2 compared with staurosporine-treated pRB- cells.	Staurosporine	159-172	cyclin dependent kinase 2	Homo sapiens	23-27
8650198-9	1996	Immunoprecipitation of CDK2, cyclin E, and p2l from staurosporine-treated pRB+ cells revealed a 2.5- to 3-fold higher ratio of p2l bound to CDK2 compared with staurosporine-treated pRB- cells.	Staurosporine	159-172	RB transcriptional corepressor 1	Homo sapiens	74-77
8650198-12	1996	This is the first evidence suggesting that G1 arrest by 4 nM staurosporine is dependent on a functional pRB protein.	Staurosporine	61-74	RB transcriptional corepressor 1	Homo sapiens	104-107
8764313-6	1996	Intrarenal infusion of either staurosporine or chelerythrine into the renal artery effectively attenuated the vasoconstriction elicited by ANG II in a dose-dependent manner, with maximum inhibition of 60-70%.	Staurosporine	30-43	angiotensinogen	Rattus norvegicus	139-145
8764317-4	1996	With both AVP and PGE2 in the bath, addition of staurosporine or chelerythrine to the bath decreased JHCO3 from 12.2 +/- 1.1 to 7.3 +/- 0.6 pmol.min-1.mm-1 (P &lt; 0.005).	Staurosporine	48-61	arginine vasopressin	Rattus norvegicus	10-13
8687383-5	1996	Up-regulation of TK activity after IL-3 readdition is prevented by the protein kinase C (PKC) inhibitor staurosporin, but not by tyrosine kinase inhibitors.	Staurosporine	104-116	interleukin 3	Mus musculus	35-39
9387792-0	1996	[Changes of intracellular calcium, calmodulin in normal and tumor cells traggered by staurosporine].	Staurosporine	85-98	calmodulin 1	Homo sapiens	35-45
9387792-3	1996	Our results showed that treatment of 5 ng/ml staurosporine for 18 h caused the changes of calcium and calmodulin.	Staurosporine	45-58	calmodulin 1	Homo sapiens	102-112
9387792-6	1996	The causes of that staurosporine blocked 2 BS cells at G 1 phase but not effected on cell cycle progression in BGC-823 cells may be the results of staurosporine decreased the contents of CaM at G 1 phase and inhibited the phosphoralation of p107 in 2 BS cells.	Staurosporine	19-32	calmodulin 1	Homo sapiens	187-190
9387792-6	1996	The causes of that staurosporine blocked 2 BS cells at G 1 phase but not effected on cell cycle progression in BGC-823 cells may be the results of staurosporine decreased the contents of CaM at G 1 phase and inhibited the phosphoralation of p107 in 2 BS cells.	Staurosporine	147-160	calmodulin 1	Homo sapiens	187-190
8652602-8	1996	By contrast, insulin action on Na+,K(+)-ATPase was impaired by the protein kinase inhibitors staurosporine and genistein.	Staurosporine	93-106	insulin	Homo sapiens	13-20
8624264-0	1996	Comparison of staurosporine and four analogues: their effects on growth, rhodamine 123 retention and binding to P-glycoprotein in multidrug-resistant MCF-7/Adr cells.	Staurosporine	14-27	ATP binding cassette subfamily B member 1	Homo sapiens	112-126
8624264-1	1996	The potent kinase inhibitor staurosporine and its protein kinase C (PKC)-selective analogue CGP 41251 are known to sensitise cells with the multidrug resistance (MDR) phenotype mediated by P-glycoprotein (P-gp) to cytotoxic agents.	Staurosporine	28-41	ATP binding cassette subfamily B member 1	Homo sapiens	189-203
8624264-1	1996	The potent kinase inhibitor staurosporine and its protein kinase C (PKC)-selective analogue CGP 41251 are known to sensitise cells with the multidrug resistance (MDR) phenotype mediated by P-glycoprotein (P-gp) to cytotoxic agents.	Staurosporine	28-41	ATP binding cassette subfamily B member 1	Homo sapiens	205-209
8624264-8	1996	Staurosporine and CGP 41251 at 10 and 20 nM, respectively, decreased efflux of the P-gp probe rhodamine 123 (R123) from MCF-7/Adr cells, whereas RO 31 8220 and GF 109203X at 640 nM were inactive.	Staurosporine	0-13	ATP binding cassette subfamily B member 1	Homo sapiens	83-87
8780012-4	1996	Moreover, pretreatment of PC12 cells with the protein kinase inhibitor staurosporine or with calphostin C, a specific inhibitor of PKC, also blocks the increase of AA release induced by NGF.	Staurosporine	71-84	protein kinase C, alpha	Rattus norvegicus	131-134
8627883-12	1996	To further confirm our findings that PKC may regulate endogenous TNF expression, a PKC inhibitor, staurosporine, was used.	Staurosporine	98-111	tumor necrosis factor	Homo sapiens	65-68
8627883-17	1996	After factoring out the cytotoxicity of staurosporine, the TNF-mediated cytotoxicity increased to 39.3% and 28.7% for the SK-RC-42 and SK-RC-49 cells, respectively.	Staurosporine	40-53	tumor necrosis factor	Homo sapiens	59-62
8622597-5	1996	Coincubation with staurosporine, a potent inhibitor of protein kinase C (PKC) activity, attenuated the LPC-induced increase in MCP-1 mRNA levels by 53%.	Staurosporine	18-31	proprotein convertase subtilisin/kexin type 7	Homo sapiens	103-106
8622597-5	1996	Coincubation with staurosporine, a potent inhibitor of protein kinase C (PKC) activity, attenuated the LPC-induced increase in MCP-1 mRNA levels by 53%.	Staurosporine	18-31	C-C motif chemokine ligand 2	Homo sapiens	127-132
8662262-4	1996	The MLC diphosphorylation was sensitive to protein kinase C down-regulation by phorbol dibutylate and pretreatment by the protein kinase inhibitors, staurosporine (30 nM) and isoquinoline sulphonamide HA1077 (20 microM).	Staurosporine	149-162	modulator of VRAC current 1	Homo sapiens	4-7
8879351-7	1996	On the other hand, staurosporine (a protein kinase C [PKC] inhibitor) treatment of cells before AII treatment was able to prevent the attenuation of both C-ANF4-23 as well as AII-mediated inhibition of adenylyl cyclase elicited by AII.	Staurosporine	19-32	angiotensinogen	Homo sapiens	96-99
8879351-7	1996	On the other hand, staurosporine (a protein kinase C [PKC] inhibitor) treatment of cells before AII treatment was able to prevent the attenuation of both C-ANF4-23 as well as AII-mediated inhibition of adenylyl cyclase elicited by AII.	Staurosporine	19-32	angiotensinogen	Homo sapiens	175-178
8879351-7	1996	On the other hand, staurosporine (a protein kinase C [PKC] inhibitor) treatment of cells before AII treatment was able to prevent the attenuation of both C-ANF4-23 as well as AII-mediated inhibition of adenylyl cyclase elicited by AII.	Staurosporine	19-32	angiotensinogen	Homo sapiens	175-178
8692888-6	1996	Furthermore, galectin-3 expression in these cells confers resistance to apoptosis induced by anti-Fas antibody and staurosporine.	Staurosporine	115-128	galectin 3	Homo sapiens	13-23
8662783-7	1996	Comparison with the immediate early response gene c-fos demonstrated that the increase in B2 receptor mRNA was similarly inhibited by the tyrosine kinase inhibitor, tyrphostin, as well as staurosporine.	Staurosporine	188-201	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-55
8662783-7	1996	Comparison with the immediate early response gene c-fos demonstrated that the increase in B2 receptor mRNA was similarly inhibited by the tyrosine kinase inhibitor, tyrphostin, as well as staurosporine.	Staurosporine	188-201	bradykinin receptor B2	Homo sapiens	90-101
24178685-7	1996	The inhibition of system B(0,+) by Ang II is mediated by protein kinase C (PKC) because it was mimicked by phorbol esters (phorbol 12-myristate 13-acetate) and was inhibited by staurosporine.	Staurosporine	177-190	angiotensinogen	Homo sapiens	35-41
8762106-17	1996	The desensitizing action of GLP-1(7-36)amide persisted in the presence of either staurosporine or forskolin and did not require an elevation of [Ca2+]i.	Staurosporine	81-94	glucagon	Mus musculus	28-33
8655577-0	1996	Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.	Staurosporine	38-51	intraflagellar transport 43	Homo sapiens	8-13
8655577-0	1996	Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.	Staurosporine	38-51	caspase 1	Homo sapiens	14-17
8799824-8	1996	This dissociation can be inhibited by staurosporine and a 26mer peptide covering amino acid positions 651 to 676 of p127 and containing five serine residues which are evolutionarily conserved from Drosophila to humans.	Staurosporine	38-51	lethal (2) giant larvae	Drosophila melanogaster	116-120
8799831-6	1996	We also show that treatment of metaphase-arrested HeLa cells with staurosporine and olomoucine, inhibitors of p34cdc2 and other protein kinases, rapidly induces reassembly of interphase nuclei and dephosphorylation of histone H1 without chromosome segregation.	Staurosporine	66-79	cyclin dependent kinase 1	Homo sapiens	110-117
8799831-6	1996	We also show that treatment of metaphase-arrested HeLa cells with staurosporine and olomoucine, inhibitors of p34cdc2 and other protein kinases, rapidly induces reassembly of interphase nuclei and dephosphorylation of histone H1 without chromosome segregation.	Staurosporine	66-79	H1.0 linker histone	Homo sapiens	218-228
8626669-4	1996	Fas- and staurosporine-induced apoptosis as well as cleavage of D4-GDI were inhibited by the ICE inhibitor, YVAD-cmk.	Staurosporine	9-22	carboxylesterase 2	Homo sapiens	93-96
8626669-4	1996	Fas- and staurosporine-induced apoptosis as well as cleavage of D4-GDI were inhibited by the ICE inhibitor, YVAD-cmk.	Staurosporine	9-22	cytidine/uridine monophosphate kinase 1	Homo sapiens	113-116
8799329-4	1996	While the PKC inhibitor, staurosporine, did not itself influence endothelial permeability, it reduced the decrease or increase in permeability induced by exposure to PMA or OAG in human and bovine AECs, respectively.	Staurosporine	25-38	proline rich transmembrane protein 2	Homo sapiens	10-13
8738867-7	1996	To determine whether the inter-action between CRH and LVP was regulated partially by the protein Kinase C (PKC) pathway, we challenged AP cells in a 30-min incubation with 10(-7) M staurosporine (ST), a treatment predicted to decrease PKC activity.	Staurosporine	181-194	corticotropin releasing hormone	Sus scrofa	46-49
8666664-8	1996	Also, we found that internalization of CD59 was prevented by the protein kinase C inhibitor staurosporine and by the protein kinase A activator forskolin.	Staurosporine	92-105	CD59 molecule (CD59 blood group)	Homo sapiens	39-43
8726973-9	1996	P67 elevated Ki values for both staurosporine and olomoucine.	Staurosporine	32-45	syntaxin binding protein 1	Rattus norvegicus	0-3
8726973-11	1996	The high affinity of staurosporine for cdk5 suggests that cdk5 may be one of the targets for the neurotropic effect of staurosporine.	Staurosporine	21-34	cyclin-dependent kinase 5	Rattus norvegicus	39-43
8726973-11	1996	The high affinity of staurosporine for cdk5 suggests that cdk5 may be one of the targets for the neurotropic effect of staurosporine.	Staurosporine	21-34	cyclin-dependent kinase 5	Rattus norvegicus	58-62
8726973-11	1996	The high affinity of staurosporine for cdk5 suggests that cdk5 may be one of the targets for the neurotropic effect of staurosporine.	Staurosporine	119-132	cyclin-dependent kinase 5	Rattus norvegicus	39-43
8726973-11	1996	The high affinity of staurosporine for cdk5 suggests that cdk5 may be one of the targets for the neurotropic effect of staurosporine.	Staurosporine	119-132	cyclin-dependent kinase 5	Rattus norvegicus	58-62
8626571-6	1996	Phosphorylation of Vif was stimulated by phorbol 12-myristate 13-acetate and inhibited by staurosporine and hypericin, a drug with potent anti-HIV activity.	Staurosporine	90-103	Vif	Human immunodeficiency virus 1	19-22
8841932-10	1996	Protein kinase C (PKC) inhibitors staurosporine (15 nM) and bisindolylmaleimide I (0.5 microM) also blocked ET effect.	Staurosporine	34-47	protein kinase C, gamma	Rattus norvegicus	18-21
8621772-3	1996	Urea inducibility of Egr-1 expression was protein kinase C (PKC)-dependent because staurosporine and calphostin C abrogated the urea effect, and down-regulation of PHC through chronic TPa treatment inhibited both urea-inducible Egr-1 protein expression and gene transcription.	Staurosporine	83-96	early growth response 1	Mus musculus	21-26
8612293-5	1996	The enhanced phagocytosis produced by a combination of hemolin and LPS was prevented by the protein kinase C (PKC) inhibitors staurosporine and H-7, and PKC activity in hemocyte crude extracts was enhanced by hemolin and LPS, with the highest activity observed in the presence of both.	Staurosporine	126-139	hemolin	Bombyx mori	55-62
8612692-17	1996	Thus, treatment of cells with staurosporin induced a partial activation of NF-kappaB and was synergistic with TNFalpha induced activation.	Staurosporine	30-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
8612692-17	1996	Thus, treatment of cells with staurosporin induced a partial activation of NF-kappaB and was synergistic with TNFalpha induced activation.	Staurosporine	30-42	tumor necrosis factor	Mus musculus	110-118
8622872-9	1996	Finally, the protein kinase C inhibitor, staurosporine, was found to interfere with p21 induction and prevent cell cycle arrest following treatment with TPA but not OA, suggesting a requirement for PKC in TPA activation of p21 expression.	Staurosporine	41-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	84-87
8622872-9	1996	Finally, the protein kinase C inhibitor, staurosporine, was found to interfere with p21 induction and prevent cell cycle arrest following treatment with TPA but not OA, suggesting a requirement for PKC in TPA activation of p21 expression.	Staurosporine	41-54	cyclin dependent kinase inhibitor 1A	Homo sapiens	223-226
8612355-4	1996	Pretreatment of T cells with staurosporine reduced the induction of NFkappaB in anti-CD3-activated cells from young mice but had no effect in similarly treated T cells from old mice.	Staurosporine	29-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	68-76
8617370-3	1996	PMA, a protein kinase C (PKC) activator, enhanced cAMP accumulation in 293AC-V cells dose-and time-dependently and this enhancement was abolished by staurosporine.	Staurosporine	149-162	protein kinase C alpha	Homo sapiens	25-28
8625914-6	1996	The protein kinase C inhibitors chelerythrine (3 microns), calphostin C (100 nM), and staurosporine (10 nM) also blocked fibroblast growth factor but not angiotensin II induction of IGF-I receptor mRNA.	Staurosporine	86-99	insulin-like growth factor 1 receptor	Rattus norvegicus	182-196
8666909-9	1996	Both PAF- and 5(S)-HETE-induced lipid body formation were inhibited by protein kinase C (PKC) inhibitors staurosporine and chelerythrine, the phospholipase C (PLC) inhibitors D609 and U-73122, and by actinomycin D and cycloheximide.	Staurosporine	105-118	patchy fur	Mus musculus	5-8
8626584-3	1996	Dominant negative mutants of CDC2, CDK2, and CDK3 each suppressed apoptosis induced by both staurosporine and tumor necrosis factor alpha, whereas a dominant negative mutant of CDK5 was without effect.	Staurosporine	92-105	cyclin dependent kinase 1	Homo sapiens	29-33
8626584-3	1996	Dominant negative mutants of CDC2, CDK2, and CDK3 each suppressed apoptosis induced by both staurosporine and tumor necrosis factor alpha, whereas a dominant negative mutant of CDK5 was without effect.	Staurosporine	92-105	cyclin dependent kinase 2	Homo sapiens	35-39
8626584-3	1996	Dominant negative mutants of CDC2, CDK2, and CDK3 each suppressed apoptosis induced by both staurosporine and tumor necrosis factor alpha, whereas a dominant negative mutant of CDK5 was without effect.	Staurosporine	92-105	cyclin dependent kinase 3	Homo sapiens	45-49
8992878-8	1996	The VEGF mRNA expression induced by 1,25-(OH)2D3 was completely inhibited by H-7, but only partially by staurosporine.	Staurosporine	104-117	vascular endothelial growth factor A	Homo sapiens	4-8
8689410-3	1996	In this study, we investigated the effect of agonists (PMA; ionomycin) and antagonists (BAPTA; staurosporine) of protein kinase C (PKC), and calcium channel on translocation and synthesis of HSF1, and activation of HSP-70 gene in human epidermoid A-431 cells.	Staurosporine	95-108	heat shock transcription factor 1	Homo sapiens	191-195
8656040-6	1996	Conversely, the effect of H/R plus PMA on CD32, CD16, CD35, and CD11b/CD18 expression was blocked by staurosporine and H-7 but not by H-9, pertussis toxin, or genistein.	Staurosporine	101-114	Fc gamma receptor IIa	Homo sapiens	42-46
8656040-6	1996	Conversely, the effect of H/R plus PMA on CD32, CD16, CD35, and CD11b/CD18 expression was blocked by staurosporine and H-7 but not by H-9, pertussis toxin, or genistein.	Staurosporine	101-114	Fc gamma receptor IIIa	Homo sapiens	48-52
8656040-6	1996	Conversely, the effect of H/R plus PMA on CD32, CD16, CD35, and CD11b/CD18 expression was blocked by staurosporine and H-7 but not by H-9, pertussis toxin, or genistein.	Staurosporine	101-114	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	54-58
8689410-11	1996	The increases in mRNA of HSF1 and HSP-70 induced by treatment with 1 mumol/L PMA were completely blocked by preincubating cells with either 2 mumol/L staurosporine in the presence of extracellular Ca2+ or 100 mumol/L BAPTA-am in absence of extracellular Ca2+.	Staurosporine	150-163	heat shock transcription factor 1	Homo sapiens	25-29
8689410-11	1996	The increases in mRNA of HSF1 and HSP-70 induced by treatment with 1 mumol/L PMA were completely blocked by preincubating cells with either 2 mumol/L staurosporine in the presence of extracellular Ca2+ or 100 mumol/L BAPTA-am in absence of extracellular Ca2+.	Staurosporine	150-163	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-40
8835783-0	1996	Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9.	Staurosporine	112-125	solute carrier family 9 member A2	Rattus norvegicus	168-171
8835783-0	1996	Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9.	Staurosporine	112-125	G protein-coupled receptor 50	Rattus norvegicus	182-185
8609894-6	1996	Preincubation with staurosporine or the specific PKC inhibitor calphostin C, before application of carbachol, fully prevented the inhibition of IRK1 by m1 muscarinic receptor stimulation.	Staurosporine	19-32	potassium inwardly rectifying channel subfamily J member 2	Homo sapiens	144-148
8602399-6	1996	In addition, treatment of hEGF-stimulated (2 ng/ml) TSU-pr1 cells with 0.5 microgram/ml anti-hEGF monoclonal antibody or 100 nM staurosporine inhibited EGFR phosphorylation.	Staurosporine	128-141	epidermal growth factor	Homo sapiens	26-30
8602399-6	1996	In addition, treatment of hEGF-stimulated (2 ng/ml) TSU-pr1 cells with 0.5 microgram/ml anti-hEGF monoclonal antibody or 100 nM staurosporine inhibited EGFR phosphorylation.	Staurosporine	128-141	epidermal growth factor receptor	Homo sapiens	152-156
8607792-2	1996	This PLD activation was hardly affected by staurosporine or Ro31-8220 (at concentrations which inhibited PMA stimulated PLD activity), indicating that it was largely independent of protein kinase C (PKC).	Staurosporine	43-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	5-8
8601464-4	1996	Different inhibitors of PKC (staurosporine, H-7 and calphostin C) increased the release of [3H]AA and inhibited beta-TG release and aggregation induced by AlF4- but they had no effect when platelets were stimulated with thrombin (0.5 U/ml).	Staurosporine	29-42	pro-platelet basic protein	Homo sapiens	112-119
8601464-4	1996	Different inhibitors of PKC (staurosporine, H-7 and calphostin C) increased the release of [3H]AA and inhibited beta-TG release and aggregation induced by AlF4- but they had no effect when platelets were stimulated with thrombin (0.5 U/ml).	Staurosporine	29-42	coagulation factor II, thrombin	Homo sapiens	220-228
8656040-6	1996	Conversely, the effect of H/R plus PMA on CD32, CD16, CD35, and CD11b/CD18 expression was blocked by staurosporine and H-7 but not by H-9, pertussis toxin, or genistein.	Staurosporine	101-114	integrin subunit alpha M	Homo sapiens	64-69
8638712-4	1996	Staurosporine and polymyxin B inhibited in a dose dependent manner the HDC activity stimulated by 10 nM gastrin.	Staurosporine	0-13	histidine decarboxylase	Oryctolagus cuniculus	71-74
8656040-6	1996	Conversely, the effect of H/R plus PMA on CD32, CD16, CD35, and CD11b/CD18 expression was blocked by staurosporine and H-7 but not by H-9, pertussis toxin, or genistein.	Staurosporine	101-114	integrin subunit beta 2	Homo sapiens	70-74
8638652-3	1996	PMA (10 nM to 1 microM; 15 min to 24 h) treatment elicited a time- and concentration-dependent decrease in the numbers of 125I-labeled ANP specific binding sites, which was inhibited by the PKC antagonist staurosporine (500 nM).	Staurosporine	205-218	protein kinase C, gamma	Rattus norvegicus	190-193
8838866-0	1996	Staurosporine resistance accompanies DNA tumor virus-induced immortalization and is independent of the expression and activities of ERK1, ERK2, cyclin A, cyclin-dependent kinase (cdk) 2, and cdk4.	Staurosporine	0-13	cyclin dependent kinase 4	Homo sapiens	191-195
8838866-7	1996	Staurosporine resistance was not the result of increased activities and/or expression of cyclin A, cyclin-dependent kinase (cdk) 2, cdk4, or the mitogen-activated kinases ERK1 and ERK2.	Staurosporine	0-13	mitogen-activated protein kinase 3	Homo sapiens	171-175
8838866-7	1996	Staurosporine resistance was not the result of increased activities and/or expression of cyclin A, cyclin-dependent kinase (cdk) 2, cdk4, or the mitogen-activated kinases ERK1 and ERK2.	Staurosporine	0-13	mitogen-activated protein kinase 1	Homo sapiens	180-184
8838866-8	1996	Although increased activities and/or expression of cyclin A and cdk2 and cdk4 proteins, but not ERK1 or ERK2, were associated with immortalization, similar increases were found in staurosporine-sensitive precrisis cells expressing SV40 tumor antigens.	Staurosporine	180-193	cyclin A2	Homo sapiens	51-59
8838866-8	1996	Although increased activities and/or expression of cyclin A and cdk2 and cdk4 proteins, but not ERK1 or ERK2, were associated with immortalization, similar increases were found in staurosporine-sensitive precrisis cells expressing SV40 tumor antigens.	Staurosporine	180-193	cyclin dependent kinase 2	Homo sapiens	64-68
8838866-8	1996	Although increased activities and/or expression of cyclin A and cdk2 and cdk4 proteins, but not ERK1 or ERK2, were associated with immortalization, similar increases were found in staurosporine-sensitive precrisis cells expressing SV40 tumor antigens.	Staurosporine	180-193	cyclin dependent kinase 4	Homo sapiens	73-77
8603924-5	1996	Moreover, two tyrosine kinase inhibitors, herbimycin and staurosporine, that blocked beta-subunit phosphorylation also blocked agrin-induced clustering.	Staurosporine	57-70	agrin	Homo sapiens	127-132
8627317-6	1996	The responsiveness to CCK-4 was also reduced by phorbol 12,13-dibutyrate (PDBu), and this effect of PDBu was abolished completely by preincubation with staurosporine.	Staurosporine	152-165	protein tyrosine kinase 7 (inactive)	Homo sapiens	22-27
8882622-9	1996	The non-selective PKC inhibitor, staurosporine (1-300 nM) significantly increased the production of IL-1 alpha-induced IL-8 mRNA and protein.	Staurosporine	33-46	interleukin 1 alpha	Homo sapiens	100-110
8882622-9	1996	The non-selective PKC inhibitor, staurosporine (1-300 nM) significantly increased the production of IL-1 alpha-induced IL-8 mRNA and protein.	Staurosporine	33-46	C-X-C motif chemokine ligand 8	Homo sapiens	119-123
8638712-4	1996	Staurosporine and polymyxin B inhibited in a dose dependent manner the HDC activity stimulated by 10 nM gastrin.	Staurosporine	0-13	gastrin	Oryctolagus cuniculus	104-111
8778231-6	1996	The basal level of c-myc expression was reduced by the protein kinase inhibitors H-7 (1-(5-isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride), staurosporine and HA1004 (N-(2-guanidinoethyl)-5-isoquinolinesulfonamide hydrochloride).	Staurosporine	151-164	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	19-24
8778231-7	1996	H-7 totally abolished ACTH-, TPA- and (Bu)2cAMP-induced c-myc expression, while staurosporine inhibited the stimulatory effects of ACTH and TPA, and HA1004 weakly inhibited the effects of ACTH and (Bu)2cAMP.	Staurosporine	80-93	proopiomelanocortin	Homo sapiens	131-135
8778231-7	1996	H-7 totally abolished ACTH-, TPA- and (Bu)2cAMP-induced c-myc expression, while staurosporine inhibited the stimulatory effects of ACTH and TPA, and HA1004 weakly inhibited the effects of ACTH and (Bu)2cAMP.	Staurosporine	80-93	proopiomelanocortin	Homo sapiens	131-135
8648181-0	1996	Staurosporine induces a sequential program of mouse keratinocyte terminal differentiation through activation of PKC isozymes.	Staurosporine	0-13	protein kinase C, alpha	Mus musculus	112-115
8661780-8	1996	These results support the concept that the volume-sensitive protein pICln regulates the Cl- channels, and that the same conduits subserve volume- and staurosporine-activated Cl- release.	Staurosporine	150-163	chloride nucleotide-sensitive channel 1A	Homo sapiens	68-73
8661780-11	1996	We suggest that ClC-3 provides the same conduit for both volume-activated and isotonically staurosporine-activated Cl- channels of human nonpigmented ciliary epithelial cells.	Staurosporine	91-104	chloride voltage-gated channel 3	Homo sapiens	16-21
8846167-7	1996	Concomitant addition of the protein kinase C (PKC) inhibitors staurosporine or H7 suppressed monocyte adherence to immobilized fibrinogen but exerted no significant effect upon adhesion to any other surface tested.	Staurosporine	62-75	fibrinogen beta chain	Homo sapiens	127-137
8626805-8	1996	Staurosporine inhibited the kinase activity of PKCalpha without affecting activation of PLD.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	47-55
8604012-11	1996	Addition of the protein kinase inhibitor staurosporine significantly inhibited IL-5-induced chemokinesis.	Staurosporine	41-54	interleukin 5	Homo sapiens	79-83
8622689-2	1996	To map the sequences in Bcl2 that are necessary for its activity, we created a library of deletion-scanning mutants of this 239-amino-acid protein and tested their abilities to block staurosporine-induced fibroblast apoptosis, using a novel transient-transfection assay.	Staurosporine	183-196	BCL2 apoptosis regulator	Homo sapiens	24-28
8611631-6	1996	Treatment with TNF-alpha for 4-24 h increased the cPLA2 protein and mRNA levels which were blocked by the broad inhibitor of protein kinases staurosporine, the protein kinase C (PKC) inhibitor calphostin C, and to a lesser extent the calcium/calmodulin-dependent protein kinase inhibitor W-7.	Staurosporine	141-154	tumor necrosis factor	Homo sapiens	15-24
8611631-6	1996	Treatment with TNF-alpha for 4-24 h increased the cPLA2 protein and mRNA levels which were blocked by the broad inhibitor of protein kinases staurosporine, the protein kinase C (PKC) inhibitor calphostin C, and to a lesser extent the calcium/calmodulin-dependent protein kinase inhibitor W-7.	Staurosporine	141-154	phospholipase A2 group IVA	Homo sapiens	50-55
8613668-5	1996	We show that staurosporine-induced apoptosis of ConA-stimulated PBL is not correlated with cell cycle stage but is selective for activated cells since the frequency of large, CD25+ cells is decreased by staurosporine.	Staurosporine	13-26	interleukin 2 receptor, alpha chain	Mus musculus	175-179
8613668-5	1996	We show that staurosporine-induced apoptosis of ConA-stimulated PBL is not correlated with cell cycle stage but is selective for activated cells since the frequency of large, CD25+ cells is decreased by staurosporine.	Staurosporine	203-216	interleukin 2 receptor, alpha chain	Mus musculus	175-179
8566594-7	1996	The protein kinase C inhibitors H-7 and staurosporine dose dependently reversed the inhibitory action of EGF, whereas H-89 (protein kinase A inhibitor) failed to alter the effect of EGF.	Staurosporine	40-53	epidermal growth factor	Canis lupus familiaris	105-108
8822342-11	1996	PKC desensitization also potentially contributed to this effect because the PKC inhibitors staurosporine and H-7 enhanced bFGF-induced and cAMP-induced NTPPPH expression in the absence of morphologic changes.	Staurosporine	91-104	fibroblast growth factor 2	Homo sapiens	122-126
8838651-9	1996	When HL60 cells were stimulated by diverse apoptosis inducers such as camptothecin, staurosporine, cycloheximide, and A23187, the extent of NuMA cleavage to produce a 180 kDa product was comparable with the degree of oligonucleosomal laddering.	Staurosporine	84-97	nuclear mitotic apparatus protein 1	Homo sapiens	140-144
8600168-12	1996	Staurosporine (500 nM), an inhibitor of protein kinase C, inhibited only 10% of ATP induced loss of L-selectin but completely inhibited the loss of L-selectin caused by 50 nM PMA.	Staurosporine	0-13	selectin L	Homo sapiens	100-110
8600168-12	1996	Staurosporine (500 nM), an inhibitor of protein kinase C, inhibited only 10% of ATP induced loss of L-selectin but completely inhibited the loss of L-selectin caused by 50 nM PMA.	Staurosporine	0-13	selectin L	Homo sapiens	148-158
8821828-10	1996	When PKC was inhibited with staurosporine, only very low levels of c-fos were induced by serum.	Staurosporine	28-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-72
8848170-3	1996	By using microdialysis in the adult rat cerebellum, we found that either an inhibitor of protein kinase C (staurosporine) or of nitric oxide synthase (Nw-nitro-L-arginine methyl ester) counteracted the long-term, but not the acute effects of insulin-like growth factor-I on glutamate-induced GABA release.	Staurosporine	107-120	insulin-like growth factor 1	Rattus norvegicus	242-270
8848170-5	1996	Finally, when both protein kinase C and nitric oxide-synthase were simultaneously inhibited by conjoint administration of staurosporine and Nw-nitro-L-arginine methyl ester, a complete blockage of both the short and the long-term effects of insulin-like growth factor-I on GABA release was obtained.	Staurosporine	122-135	insulin-like growth factor 1	Rattus norvegicus	241-269
8635587-5	1996	In contrast, in apoptotic cells induced by pharmaceutical PKC inhibitors H7 or staurosporine, expression of bcl-2 did not change nor did the intracellular sphingosine concentration.	Staurosporine	79-92	BCL2 apoptosis regulator	Homo sapiens	108-113
8555268-9	1996	A hydrolyzable form of ATP was necessary for maximum AA release and staurosporin inhibited PLA2 activation.	Staurosporine	68-80	phospholipase A2 group IB	Homo sapiens	91-95
8557709-5	1996	Tyrosine kinase inhibitors K-252a and staurosporine, known to inhibit the neurotrophic effect of NGF, also inhibited these effects of plasmalopsychosine, suggesting that plasmalopsychosine and NGF share a common signaling cascade.	Staurosporine	38-51	nerve growth factor	Rattus norvegicus	97-100
8557709-5	1996	Tyrosine kinase inhibitors K-252a and staurosporine, known to inhibit the neurotrophic effect of NGF, also inhibited these effects of plasmalopsychosine, suggesting that plasmalopsychosine and NGF share a common signaling cascade.	Staurosporine	38-51	nerve growth factor	Rattus norvegicus	193-196
9244191-6	1996	HB-EGF in Mahlavu cells appears to be regulated by a protein kinase C (PKC) pathway, since PKC inhibitors, H7, staurosporin, and calphostin C, abrogated the induction of HB-EGF mRNA by TPA.	Staurosporine	111-123	heparin binding EGF like growth factor	Homo sapiens	0-6
9244191-6	1996	HB-EGF in Mahlavu cells appears to be regulated by a protein kinase C (PKC) pathway, since PKC inhibitors, H7, staurosporin, and calphostin C, abrogated the induction of HB-EGF mRNA by TPA.	Staurosporine	111-123	heparin binding EGF like growth factor	Homo sapiens	170-176
8738488-3	1996	The PKC inhibitors Staurosporine and Tamoxifen were added at varying dosages to the cell cultures.	Staurosporine	19-32	proline rich transmembrane protein 2	Homo sapiens	4-7
8886182-9	1996	These actions of PTH were mimicked by dibutyryl cyclic AMP and 12-o-tetradecanoylphorbol-13-acetate(TPA) and were abolished by H-89 (an inhibitor of protein kinase A), staurosporine (an inhibitor of protein kinase C), and the calcium channel blockers verapamil or nifedipine.	Staurosporine	168-181	parathyroid hormone	Homo sapiens	17-20
8772525-7	1996	The sustained phase of the contraction to ET-1 in all three species may be mediated in part by activation of protein kinase C (PKC), as the inhibitor staurosporine significantly altered the time course of the response to endothelin.	Staurosporine	150-163	endothelin 1	Homo sapiens	42-46
8679777-6	1996	Addition of staurosporine (10 nM) during incubation of the slices abolished the PRL effect on protein phosphorylation without any effect on the rate of unstimulated phosphorylation.	Staurosporine	12-25	prolactin	Cavia porcellus	80-83
8679777-9	1996	Staurosporine only slightly attenuated the PRL effect.	Staurosporine	0-13	prolactin	Cavia porcellus	43-46
8548752-7	1996	The broad protein kinase inhibitor staurosporine inhibited phosphorylation of pp65a and pp65b, supporting the hypothesis that activation of a LAK protein kinase leads to p65 phosphorylation.	Staurosporine	35-48	RELA proto-oncogene, NF-kB subunit	Homo sapiens	79-82
17180051-5	1996	We investigated the role of HGF as a survival factor in protecting cells from apoptosis and we show that HGF is able to counteract staurosporin-induced apoptosis of epithelial cells.	Staurosporine	131-143	hepatocyte growth factor	Homo sapiens	105-108
8640446-3	1996	In the present studies of HLA-DR expression, the PKC inhibitor staurosporine (0.1-1 nM) enhanced the expression of HLA-DR when the inhibitor was added simultaneously with IFN-gamma, 100 IU/ml.	Staurosporine	63-76	interferon gamma	Homo sapiens	171-180
8640446-4	1996	In the presence of IFN-gamma and 10(-7) M T4, the same concentrations of staurosporine inhibited potentiation of HLA-DR expression by thyroid hormone.	Staurosporine	73-86	interferon gamma	Homo sapiens	19-28
8770956-5	1996	However, regulation of IsK by PTH was mimicked by activators of protein kinase A (PKA) and greatly reduced in the presence of the kinase inhibitors staurosporine and H89.	Staurosporine	148-161	potassium channel, voltage gated subfamily E regulatory beta subunit 1 L homeolog	Xenopus laevis	23-26
8620456-9	1996	PLD activity induced by HePC was totally inhibited by cellular pretreatment with phorbol dibutyrate, and 59% diminished by pretreatment of cells with staurosporine, a protein kinase C (PKC) inhibitor.	Staurosporine	150-163	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
8884924-6	1996	A protein kinase C inhibitor staurosporine, added to the incubation medium, significantly reduced the enhanced specific photolabelling after ET-1.	Staurosporine	29-42	endothelin 1	Rattus norvegicus	141-145
8996546-4	1996	In both parental drug sensitive HL-60 cells and Pgp/p170 positive (MDR1) HL-60/VCR, staurosporine-stimulated AraC-induced apoptosis was higher than that stimulated by the PKC selective CGP 41251 inhibitor, or PTK-inhibitor genistein.	Staurosporine	84-97	phosphoglycolate phosphatase	Homo sapiens	48-51
8996546-4	1996	In both parental drug sensitive HL-60 cells and Pgp/p170 positive (MDR1) HL-60/VCR, staurosporine-stimulated AraC-induced apoptosis was higher than that stimulated by the PKC selective CGP 41251 inhibitor, or PTK-inhibitor genistein.	Staurosporine	84-97	ATP binding cassette subfamily B member 1	Homo sapiens	67-71
8996546-4	1996	In both parental drug sensitive HL-60 cells and Pgp/p170 positive (MDR1) HL-60/VCR, staurosporine-stimulated AraC-induced apoptosis was higher than that stimulated by the PKC selective CGP 41251 inhibitor, or PTK-inhibitor genistein.	Staurosporine	84-97	protein tyrosine kinase 2 beta	Homo sapiens	209-212
8584423-3	1996	The increase in ICa caused by Ca2+ loading was not mediated by phosphorylation since the kinase inhibitors H-8 ?N-[2-(methylamino)-ethyl]-5-isoquinolinesulphonamide dihydrochloride?, staurosporine and KN-62 ?1-[N,O-bis(5-isoquinolinesulphonyl)-N-methyl-1-tyrosyl]-4- phenylpiperizine?	Staurosporine	183-196	calcium voltage-gated channel subunit alpha1 C	Canis lupus familiaris	16-19
8807708-3	1996	The data presented show that the thrombin receptor messenger RNA is expressed in cultured astrocytes and that the reversal of stellation caused by thrombin in these cells is prevented by the protein kinase inhibitor staurosporine.	Staurosporine	216-229	coagulation factor II (thrombin) receptor	Rattus norvegicus	33-50
12237684-0	1996	The regulation of N-Acetylglucosaminyl Transferase III by Protein Kinase C. The activity of N-acetylglucosaminyl transferase III (GnT III) in 7721 human heptocarcinoma cell was inhibited by two non-specific Ser/Thr protein kinase inhibitors, quercetin and trifluoperazine, and two PKC specific inhibitors, D-sphingosine and staurosporine.	Staurosporine	324-337	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	130-137
12237684-2	1996	Quercetin, D-sphingosine and staurosporine also blocked the PMA activation of GnT-III.	Staurosporine	29-42	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	78-85
12237684-3	1996	The inhibitory effects on m-PKC and GnT III were generally proportional to the concentration of quercetin and staurosporine.	Staurosporine	110-123	beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase	Homo sapiens	36-43
8807708-3	1996	The data presented show that the thrombin receptor messenger RNA is expressed in cultured astrocytes and that the reversal of stellation caused by thrombin in these cells is prevented by the protein kinase inhibitor staurosporine.	Staurosporine	216-229	coagulation factor II	Rattus norvegicus	33-41
8747522-5	1996	Pretreatment with protein kinase C inhibitors, H-7 or staurosporine, partially suppressed the PAI activity induced by plasmin.	Staurosporine	54-67	serpin family E member 1	Homo sapiens	94-97
8747522-5	1996	Pretreatment with protein kinase C inhibitors, H-7 or staurosporine, partially suppressed the PAI activity induced by plasmin.	Staurosporine	54-67	plasminogen	Homo sapiens	118-125
8750735-1	1995	We examined the effects of staurosporine, a protein kinase inhibitor, on Ca2+ movements and contractions due to KCl and 12-deoxyphorbol 13-isobutyrate (DPB), which are thought to activate myosin light chain kinase and protein kinase C, respectively.	Staurosporine	27-40	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	188-213
8750735-7	1995	The results indicate that staurosporine preferentially inhibits a contraction dependent on protein kinase C than that dependent on myosin light chain kinase in vascular smooth muscles.	Staurosporine	26-39	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	131-156
8554578-5	1995	LTA-induced expression of E-selectin was inhibited by protein kinase C inhibitors, H-7 and staurosporine.	Staurosporine	91-104	selectin E	Homo sapiens	26-36
8788920-8	1995	A protein kinase inhibitor, staurosporine, inhibited the MPP(+)-induced increase in the Bcl-2 protein level, but not the MPP(+)-induced cell death.	Staurosporine	28-41	BCL2 apoptosis regulator	Homo sapiens	88-93
8568921-1	1995	The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG).	Staurosporine	272-285	nerve growth factor	Rattus norvegicus	77-80
8530412-6	1995	PAM-1 protein recovered from different subcellular fractions of stably transfected AtT-20 cells was differentially susceptible to calcium-dependent, staurosporine-inhibitable phosphorylation catalyzed by endogenous cytosolic protein kinase(s).	Staurosporine	149-162	F11 receptor	Homo sapiens	0-5
8530417-8	1995	The phorbol ester-induced increase in prodynorphin gene transcription was prevented by pretreatment of myocytes or isolated nuclei with staurosporine, suggesting that myocardial opioid gene expression may be regulated by nuclear protein kinase C. In this regard, cardiac myocytes expressed protein kinase C-alpha, -delta, -epsilon, and -zeta, as shown by immunoblotting.	Staurosporine	136-149	prodynorphin	Rattus norvegicus	38-50
8748153-2	1995	Quercetin, a non-specific inhibitor of Ser/Thr protein kinase, and D-sphingosine and staurosporine, two specific inhibitors of PKC, blocked the activation of membranous PKC and GnT-V by PMA.	Staurosporine	85-98	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	177-182
8619367-13	1995	On the other hand, 10 nM staurosporine and 100 nM calphostin C, protein kinase C (PKC) inhibitors, blunted the effects of hPTHrP(1-34) or bPTH(3-34) on DNA synthesis in these cells.	Staurosporine	25-38	parathyroid hormone like hormone	Homo sapiens	122-128
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Staurosporine	176-189	interleukin 1 alpha	Homo sapiens	42-55
7595543-3	1995	Complete to nearly complete inhibition of interleukin-1 beta-induced interleukin-6 production was observed with the flavonoids genistein and quercetin, the bisindole alkaloids staurosporine and K-252a, or the tyrphostin AG879.	Staurosporine	176-189	interleukin 6	Homo sapiens	69-82
8750912-6	1995	The effect of thrombin seemed to be unrelated to intracellular Ca2+ release but could be partially mimicked by phorbol ester (PMA)-induced stimulation of protein kinase C (PKC) and was inhibited by staurosporin or by inactivation of PKC after long-term incubation with PMA.	Staurosporine	198-210	coagulation factor II, thrombin	Homo sapiens	14-22
7488218-5	1995	The protein kinase c inhibitor, staurosporine, inhibited the mitogenic effect of TGF-beta.	Staurosporine	32-45	transforming growth factor, beta 1	Mus musculus	81-89
8751157-6	1995	The PMA-induced expression of Gi alpha-1/2 and Gs alpha subunits was blocked to control level by both genistein and staurosporine, inhibitors of protein tyrosine kinase and protein kinase C, respectively.	Staurosporine	116-129	GNAS complex locus	Homo sapiens	47-55
8751157-6	1995	The PMA-induced expression of Gi alpha-1/2 and Gs alpha subunits was blocked to control level by both genistein and staurosporine, inhibitors of protein tyrosine kinase and protein kinase C, respectively.	Staurosporine	116-129	TXK tyrosine kinase	Homo sapiens	153-168
7499223-5	1995	However, in the presence of the protein kinase inhibitor staurosporine, stimulation with GR64349 or (Nle10)-NKA(4-10) induced receptor desensitization.	Staurosporine	57-70	tachykinin precursor 1 S homeolog	Xenopus laevis	108-111
7499223-8	1995	In the presence of either staurosporine or Ro-31-8220, the mutant receptor was desensitized in response to NKA application but not to GR64349.	Staurosporine	26-39	tachykinin precursor 1 S homeolog	Xenopus laevis	107-110
7592882-5	1995	Moreover, drugs that interfere with TCR-mediated signals, such as cyclosporin A and staurosporin, prevented both apoptosis and the appearance of the RNA-binding factors.	Staurosporine	84-96	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	36-39
8589330-8	1995	The activation of protein kinase C (PKC) by phorbol 12, 13-dibutyrate resulted in a stimulation of the tyrosine phosphorylation of p125FAK, and an inhibition of PKC by calphostin C or staurosporine significantly reduced the effect of ET-1.	Staurosporine	184-197	protein tyrosine kinase 2	Rattus norvegicus	131-138
7593220-9	1995	It is concluded that thrombin induces MAP kinase activation in astrocytes by a mechanism involving a staurosporine-sensitive pathway.	Staurosporine	101-114	coagulation factor II	Rattus norvegicus	21-29
7578017-5	1995	Staurosporine totally blocked PMA-induced phosphorylation but only partially inhibited IL-8-mediated phosphorylation.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
7478584-3	1995	We report here that treatment of normal human fibroblast strains with inhibitors of calmodulin (CaM) (i.e. W7 and W13) and CaM-dependent protein kinases II and IV (i.e. KN62) prior to radiation exposure elicits an "A-T-like" RDS phenotype, whereas treatment with PKC inhibitors (e.g. staurosporine) does not produce this response.	Staurosporine	284-297	calmodulin 1	Homo sapiens	123-126
7590309-1	1995	Mutations of genes involved in the STT1/PKC1 pathway in yeast show staurosporine and temperature sensitivities (stt) which are suppressed by the addition of 1 M sorbitol [Yoshida et al., Mol.	Staurosporine	67-80	protein kinase C	Saccharomyces cerevisiae S288C	35-39
7590309-1	1995	Mutations of genes involved in the STT1/PKC1 pathway in yeast show staurosporine and temperature sensitivities (stt) which are suppressed by the addition of 1 M sorbitol [Yoshida et al., Mol.	Staurosporine	67-80	protein kinase C	Saccharomyces cerevisiae S288C	40-44
7559552-8	1995	TNF effect on IRS-1 tyrosine phosphorylation was not abolished by inhibiting protein kinase C using staurosporine, while inactivation of Ser/Thr phosphatases by calyculin A and okadaic acid mimicked it.	Staurosporine	100-113	tumor necrosis factor	Rattus norvegicus	0-3
7568166-7	1995	In guard cells from the abi1-1 transformants, normal sensitivity of both K+ channels to and stomatal closure in ABA was recovered in the presence of 100 microM H7 and 0.5 microM staurosporine, both broad-range protein kinase antagonists.	Staurosporine	178-191	abl interactor 1	Homo sapiens	24-28
7575484-5	1995	This cell-free system does not require ATP and is insensitive to all other inhibitors of protein kinases tested, including some highly effective against MLCK (i.e. staurosporine).	Staurosporine	164-177	myosin light chain kinase	Homo sapiens	153-157
7671329-4	1995	Moreover, inhibition of protein kinase C (PKC) by pretreatment of Bal-17 B cells with staurosporine, H7, or by phorbol ester-induced down-regulation of PKC activity blocked anti-Ig-stimulated fosB gene expression.	Staurosporine	86-99	chemokine (C-X-C motif) ligand 9	Mus musculus	178-180
7664693-4	1995	This FSH and IGF-I stimulated CytPTK activity was blocked by AG-82 (a tyrosine kinase inhibitor) and by staurosporine (STS) (a non specific protein kinase inhibitor) at concentrations which inhibited E2 production.	Staurosporine	104-117	insulin like growth factor 1	Homo sapiens	13-18
7664693-4	1995	This FSH and IGF-I stimulated CytPTK activity was blocked by AG-82 (a tyrosine kinase inhibitor) and by staurosporine (STS) (a non specific protein kinase inhibitor) at concentrations which inhibited E2 production.	Staurosporine	119-122	insulin like growth factor 1	Homo sapiens	13-18
8608187-10	1995	The results indicate that phospholipase A2 activation is involved in the phorbol ester-mediated increase in colony formation, since, of the different agents applied, only staurosporine, an inhibitor of protein kinase C, and mepacrine and heparin, putative inhibitors of phospholipase A2, were capable of abolishing phorbol ester-mediated effects.	Staurosporine	171-184	phospholipase A2, group IB, pancreas	Mus musculus	26-42
23282387-8	1995	The action of GROa was independent of cytochalasin D, staurosporine, and pertussis toxin but was inhibited by sodium azide and cycloheximide.	Staurosporine	54-67	C-X-C motif chemokine ligand 1	Homo sapiens	14-18
8573741-6	1995	Increasing PKC activity by treatment with a DAG analogue or active phorbol ester stimulated luciferase activity preferentially in G100; addition of the PKC inhibitors staurosporine or calphostin C markedly inhibited luciferase activity preferentially in G450.	Staurosporine	167-180	protein kinase C, gamma	Rattus norvegicus	11-14
8573741-6	1995	Increasing PKC activity by treatment with a DAG analogue or active phorbol ester stimulated luciferase activity preferentially in G100; addition of the PKC inhibitors staurosporine or calphostin C markedly inhibited luciferase activity preferentially in G450.	Staurosporine	167-180	protein kinase C, gamma	Rattus norvegicus	152-155
7561844-0	1995	Staurosporine induces astrocytic phenotypes and differential expression of specific PKC isoforms in C6 glial cells.	Staurosporine	0-13	protein kinase C epsilon	Homo sapiens	84-87
7561844-1	1995	In this study we examined the effects of staurosporine, a potent inhibitor of protein kinase C (PKC), on the differentiation of C6 glial cells and on the expression and cellular distribution of specific PKC isoforms.	Staurosporine	41-54	protein kinase C epsilon	Homo sapiens	96-99
7561844-3	1995	The differentiative effect of staurosporine was further indicated by the increased expression of two proteins related to astrocytic phenotypes, glial fibrillary acidic protein (GFAP) and glutamine synthetase.	Staurosporine	30-43	glial fibrillary acidic protein	Homo sapiens	144-175
7561844-3	1995	The differentiative effect of staurosporine was further indicated by the increased expression of two proteins related to astrocytic phenotypes, glial fibrillary acidic protein (GFAP) and glutamine synthetase.	Staurosporine	30-43	glial fibrillary acidic protein	Homo sapiens	177-181
7561844-3	1995	The differentiative effect of staurosporine was further indicated by the increased expression of two proteins related to astrocytic phenotypes, glial fibrillary acidic protein (GFAP) and glutamine synthetase.	Staurosporine	30-43	glutamate-ammonia ligase	Homo sapiens	187-207
7561844-4	1995	Thus, staurosporine induced a dose-dependent increase both in GFAP immunoreactivity and in the activity and protein levels of glutamine synthetase.	Staurosporine	6-19	glial fibrillary acidic protein	Homo sapiens	62-66
7561844-4	1995	Thus, staurosporine induced a dose-dependent increase both in GFAP immunoreactivity and in the activity and protein levels of glutamine synthetase.	Staurosporine	6-19	glutamate-ammonia ligase	Homo sapiens	126-146
7561844-5	1995	Staurosporine also induced a decrease in the expression of PKC-beta 2 and an increase in that of PKC-gamma.	Staurosporine	0-13	protein kinase C gamma	Homo sapiens	97-106
7561844-7	1995	The results of our study indicate that staurosporine induced astrocytic phenotypes in glial cells and that changes in the expression and cellular distribution of these PKC isoforms may be related to astrocytic differentiation.	Staurosporine	39-52	protein kinase C epsilon	Homo sapiens	168-171
8568921-9	1995	Inhibition by 5-7.5 nM staurosporine acted rapidly to arrest and decrease development of neurites up to 24 hr after NGF treatment, as did K252a and NGF polyclonal antibody addition.	Staurosporine	23-36	nerve growth factor	Rattus norvegicus	116-119
8568921-10	1995	Our cellular data support the concept that staurosporine acts to inhibit the NGF receptor Trk (Nye et al.	Staurosporine	43-56	nerve growth factor	Rattus norvegicus	77-80
8568921-10	1995	Our cellular data support the concept that staurosporine acts to inhibit the NGF receptor Trk (Nye et al.	Staurosporine	43-56	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	90-93
8568921-11	1995	: Mol Biol Cell 3:677-686, 1992), but that downstream steps can be activated by the higher concentration of staurosporine to bypass Trk and lead to neurite generation.	Staurosporine	108-121	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	132-135
8568921-12	1995	Effects of staurosporine, 6-TG, and sphingosine on c-fos gene induction with or without NGF were not correlated with the generation of neurites.	Staurosporine	11-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-56
7556684-5	1995	Protein kinase inhibitors, 2-aminopurine and staurosporine, suppressed the delta 12-PGJ2-induced HO-1 mRNA and the nuclear protein binding to the delta 12-PGJ2-responsive cis-regulatory element in rat basophilic leukemia cells.	Staurosporine	45-58	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	0-14
7556684-5	1995	Protein kinase inhibitors, 2-aminopurine and staurosporine, suppressed the delta 12-PGJ2-induced HO-1 mRNA and the nuclear protein binding to the delta 12-PGJ2-responsive cis-regulatory element in rat basophilic leukemia cells.	Staurosporine	45-58	heme oxygenase 1	Rattus norvegicus	97-101
7575518-0	1995	Staurosporine potentiates cAMP-mediated promoter activity of the vasoactive intestinal polypeptide gene in rat pheochromocytoma PC12 cells.	Staurosporine	0-13	vasoactive intestinal peptide	Rattus norvegicus	65-98
7575518-2	1995	To explore how staurosporine regulates cAMP signaling pathway, we examined transcriptional activity of the human vasoactive intestinal polypeptide (VIP) gene promoter carrying a cAMP-responsive element.	Staurosporine	15-28	vasoactive intestinal peptide	Homo sapiens	113-146
7575518-2	1995	To explore how staurosporine regulates cAMP signaling pathway, we examined transcriptional activity of the human vasoactive intestinal polypeptide (VIP) gene promoter carrying a cAMP-responsive element.	Staurosporine	15-28	vasoactive intestinal peptide	Homo sapiens	148-151
7575518-3	1995	In PC12 cells stably transfected with a reporter plasmid, staurosporine alone had little effect; however, in combination with forskolin or dibutyryl cAMP, staurosporine dose-dependently (1-50 nM) enhanced cAMP-mediated transcription from the VIP gene promoter, which was comparable to that maximally induced by cAMP plus 12-O-tetradecanoylphorbol-13-acetate.	Staurosporine	155-168	vasoactive intestinal peptide	Rattus norvegicus	242-245
7545678-6	1995	These data, together with in vitro kinase inhibitor studies, suggest that an as yet uncharacterized H7- and staurosporine-sensitive 110-kDa Ser/Thr kinase may be constitutively associated with the IL-3R and activated following IL-3 stimulation.	Staurosporine	108-121	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	Mus musculus	197-202
7545678-6	1995	These data, together with in vitro kinase inhibitor studies, suggest that an as yet uncharacterized H7- and staurosporine-sensitive 110-kDa Ser/Thr kinase may be constitutively associated with the IL-3R and activated following IL-3 stimulation.	Staurosporine	108-121	interleukin 3	Mus musculus	197-201
7677742-2	1995	Both H7 (serine/threonine kinase inhibitor) and staurosporine (protein kinase C inhibitor) were able to induce p21 protein in a time- and dose-dependent manner.	Staurosporine	48-61	H3 histone pseudogene 16	Homo sapiens	111-114
8568921-1	1995	The effects of a series of protein kinase inhibitors on nerve growth factor (NGF)-dependent and NGF-independent neurite outgrowth in PC12 cells have established an ordered relationship among those protein kinases sensitive to down regulation by bryostatin, stimulation by staurosporine, inhibition by sphingosine, or inhibition by 6-thioguanine (6-TG).	Staurosporine	272-285	nerve growth factor	Rattus norvegicus	96-99
8568921-2	1995	Quantitation of the biphasic staurosporine effects on NGF-induced neurite outgrowth (Hashimoto and Hagino: J Neurochem 53:1675-1685, 1989) gave an IC50 of 2-4 nM for inhibition and an EC50 of 15-20 nM for induction of neurite extension.	Staurosporine	29-42	nerve growth factor	Rattus norvegicus	54-57
7573482-3	1995	Both staurosporine (5 x 10(-8) M) and calphostin C (10(-8) M), inhibitors of protein kinase C, blocked the EGF stimulation of JPhos, indicating that protein kinase C is involved in EGF signaling.	Staurosporine	5-18	pro-epidermal growth factor	Oryctolagus cuniculus	107-110
7573482-3	1995	Both staurosporine (5 x 10(-8) M) and calphostin C (10(-8) M), inhibitors of protein kinase C, blocked the EGF stimulation of JPhos, indicating that protein kinase C is involved in EGF signaling.	Staurosporine	5-18	pro-epidermal growth factor	Oryctolagus cuniculus	181-184
8572580-5	1995	Staurosporine and H-7, PKC inhibitors, strongly blocked the fetal bovine serum-dependent accumulation of asparagine synthetase mRNA.	Staurosporine	0-13	asparagine synthetase	Mus musculus	105-126
8861714-5	1995	Of the protein kinase C inhibitors tested, staurosporine (10(-9) - 3 x 10(-6) M) and Ro 31-8220 (3 x 10(-9) - 10(-5) M) produced a powerful, concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but had only slight inhibitory effects when added 12 hours after stimulation with LPS and IFN-gamma.	Staurosporine	43-56	interferon regulatory factor 6	Homo sapiens	237-240
8861714-5	1995	Of the protein kinase C inhibitors tested, staurosporine (10(-9) - 3 x 10(-6) M) and Ro 31-8220 (3 x 10(-9) - 10(-5) M) produced a powerful, concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but had only slight inhibitory effects when added 12 hours after stimulation with LPS and IFN-gamma.	Staurosporine	43-56	interferon gamma	Homo sapiens	245-254
8861714-5	1995	Of the protein kinase C inhibitors tested, staurosporine (10(-9) - 3 x 10(-6) M) and Ro 31-8220 (3 x 10(-9) - 10(-5) M) produced a powerful, concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but had only slight inhibitory effects when added 12 hours after stimulation with LPS and IFN-gamma.	Staurosporine	43-56	interferon regulatory factor 6	Homo sapiens	338-341
8861714-5	1995	Of the protein kinase C inhibitors tested, staurosporine (10(-9) - 3 x 10(-6) M) and Ro 31-8220 (3 x 10(-9) - 10(-5) M) produced a powerful, concentration-dependent inhibition of nitrite accumulation when added prior to stimulation with LPS and IFN-gamma, but had only slight inhibitory effects when added 12 hours after stimulation with LPS and IFN-gamma.	Staurosporine	43-56	interferon gamma	Homo sapiens	346-355
8861714-9	1995	When used in combination prior to stimulation with LPS and IFN-gamma, herbimycin A (1.7 x 10(-7) M) and staurosporine (3 x 10(-8) M) produced additive inhibitory effects on nitrite accumulation, but herbimycin A, together with Ro 31-8220 (3 x 10(-6) M) or chelerythrine chloride (10(-5) M), produced no further effects.	Staurosporine	104-117	interferon regulatory factor 6	Homo sapiens	51-54
8861714-9	1995	When used in combination prior to stimulation with LPS and IFN-gamma, herbimycin A (1.7 x 10(-7) M) and staurosporine (3 x 10(-8) M) produced additive inhibitory effects on nitrite accumulation, but herbimycin A, together with Ro 31-8220 (3 x 10(-6) M) or chelerythrine chloride (10(-5) M), produced no further effects.	Staurosporine	104-117	interferon gamma	Homo sapiens	59-68
8528546-4	1995	The staurosporine-induced nitrite accumulation, in both the presence and the absence of TNF alpha and/or db cyclic AMP was effectively inhibited by the protein synthesis inhibitor, cycloheximide, or by the nitric oxide (NO) synthesis inhibitor, NG-monomethyl-L-arginine (L-NMMA).	Staurosporine	4-17	tumor necrosis factor	Rattus norvegicus	88-97
7649096-5	1995	PTH-stimulated phosphate uptake also was strongly dependent upon receptor expression, correlated well with PLC activity, was mimicked by active phorbol esters but not by cAMP analogs or forskolin, and was strikingly inhibited by the protein kinase C inhibitor, staurosporine.	Staurosporine	261-274	parathyroid hormone	Sus scrofa	0-3
8552303-4	1995	The potent PKC activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), also stimulated RCEC proliferation, whereas the inhibition of PKC by staurosporine caused a concomitant loss in ACM-induced PKC translocation, MARCKS protein phosphorylation and DNA synthesis.	Staurosporine	140-153	protein kinase C, gamma	Rattus norvegicus	133-136
8552303-4	1995	The potent PKC activator, 12-O-tetradecanoyl phorbol 13-acetate (TPA), also stimulated RCEC proliferation, whereas the inhibition of PKC by staurosporine caused a concomitant loss in ACM-induced PKC translocation, MARCKS protein phosphorylation and DNA synthesis.	Staurosporine	140-153	protein kinase C, gamma	Rattus norvegicus	133-136
7664838-0	1995	CDK4/cyclin D1/PCNA complexes during staurosporine-induced G1 arrest and G0 arrest of human fibroblasts.	Staurosporine	37-50	cyclin dependent kinase 4	Homo sapiens	0-4
7664838-0	1995	CDK4/cyclin D1/PCNA complexes during staurosporine-induced G1 arrest and G0 arrest of human fibroblasts.	Staurosporine	37-50	cyclin D1	Homo sapiens	5-14
7664838-0	1995	CDK4/cyclin D1/PCNA complexes during staurosporine-induced G1 arrest and G0 arrest of human fibroblasts.	Staurosporine	37-50	proliferating cell nuclear antigen	Homo sapiens	15-19
8536940-9	1995	In Experiment 4, 10(-6) M staurosporine (ST; PKC antagonist) decreased both 10(-7) M VIP-stimulated PRL secretion from 7.86 +/- 2.9 to 2.43 +/- 0.5 micrograms/5 x 10(5) cells and 10(-8) M PMA-stimulated PRL secretion from 4.26 +/- 0.2 to 2.23 +/- 0.3 micrograms/5 x 10(5) cells (P &lt; 0.01).	Staurosporine	26-39	VIP peptides	Meleagris gallopavo	85-88
8536940-9	1995	In Experiment 4, 10(-6) M staurosporine (ST; PKC antagonist) decreased both 10(-7) M VIP-stimulated PRL secretion from 7.86 +/- 2.9 to 2.43 +/- 0.5 micrograms/5 x 10(5) cells and 10(-8) M PMA-stimulated PRL secretion from 4.26 +/- 0.2 to 2.23 +/- 0.3 micrograms/5 x 10(5) cells (P &lt; 0.01).	Staurosporine	26-39	prolactin	Meleagris gallopavo	100-103
8536940-9	1995	In Experiment 4, 10(-6) M staurosporine (ST; PKC antagonist) decreased both 10(-7) M VIP-stimulated PRL secretion from 7.86 +/- 2.9 to 2.43 +/- 0.5 micrograms/5 x 10(5) cells and 10(-8) M PMA-stimulated PRL secretion from 4.26 +/- 0.2 to 2.23 +/- 0.3 micrograms/5 x 10(5) cells (P &lt; 0.01).	Staurosporine	26-39	prolactin	Meleagris gallopavo	203-206
7595139-8	1995	In the presence of staurosporine, an inhibitor of protein kinase C (PKC), the magnitude of the increase in tyrosinase due to PMA, ACTH and di-MSH was significantly reduced.	Staurosporine	19-32	tyrosinase	Homo sapiens	107-117
7595139-8	1995	In the presence of staurosporine, an inhibitor of protein kinase C (PKC), the magnitude of the increase in tyrosinase due to PMA, ACTH and di-MSH was significantly reduced.	Staurosporine	19-32	proopiomelanocortin	Homo sapiens	130-134
7595139-8	1995	In the presence of staurosporine, an inhibitor of protein kinase C (PKC), the magnitude of the increase in tyrosinase due to PMA, ACTH and di-MSH was significantly reduced.	Staurosporine	19-32	proopiomelanocortin	Homo sapiens	142-145
7637029-1	1995	Treatment of murine Friend cells with a dose of the protein kinase inhibitor staurosporine, which is able to block the response of the cells to interferons, appears to inhibit phosphorylation of Jak proteins and, interestingly, to specifically reduce tyk2 and Jak1 expression and to increase Jak2 both in the presence and in the absence of interferons.	Staurosporine	77-90	tyrosine kinase 2	Mus musculus	251-255
7637029-1	1995	Treatment of murine Friend cells with a dose of the protein kinase inhibitor staurosporine, which is able to block the response of the cells to interferons, appears to inhibit phosphorylation of Jak proteins and, interestingly, to specifically reduce tyk2 and Jak1 expression and to increase Jak2 both in the presence and in the absence of interferons.	Staurosporine	77-90	Janus kinase 1	Mus musculus	260-264
7637029-1	1995	Treatment of murine Friend cells with a dose of the protein kinase inhibitor staurosporine, which is able to block the response of the cells to interferons, appears to inhibit phosphorylation of Jak proteins and, interestingly, to specifically reduce tyk2 and Jak1 expression and to increase Jak2 both in the presence and in the absence of interferons.	Staurosporine	77-90	Janus kinase 2	Mus musculus	292-296
7543529-8	1995	DATK44-induced aggregation of TK1 cells is temperature sensitive and blocked by pretreatment of the cells with metabolic inhibitors, genestein, dibutyl cAMP or cytochalasin B, while colchicine, staurosporin, sphingosine, okadaic acid, and W7 are without effect.	Staurosporine	194-206	thymidine kinase 1	Homo sapiens	30-33
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Staurosporine	13-26	C-X-C motif chemokine ligand 1	Homo sapiens	93-102
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Staurosporine	13-26	C-X-C motif chemokine ligand 1	Homo sapiens	103-107
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Staurosporine	13-26	coagulation factor II, thrombin	Homo sapiens	111-119
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Staurosporine	13-26	interleukin 1 beta	Homo sapiens	194-212
7482442-6	1995	In addition, staurosporine, a protein kinase C (PKC) inhibitor, attenuated the production of GRO alpha/MGSA by thrombin, SFLLRN and phorbol 12-myristate 13-acetate (PMA), but left the action of interleukin-1 beta (IL-1 beta) unchanged.	Staurosporine	13-26	interleukin 1 beta	Homo sapiens	214-223
7543105-11	1995	Staurosporine and calphostin C, inhibitors of protein kinase C, blocked internalization and subsequent degradation of vitronectin, while KT5720, an inhibitor of protein kinase A, had no effect on the degradation of vitronectin.	Staurosporine	0-13	vitronectin	Homo sapiens	118-129
8690728-4	1995	The stimulatory effect of PMA was further enhanced in the presence of okadaic acid, but it was strongly inhibited in the presence of 0.5 microM staurosporine, an inhibitor of protein kinase C. PMA and okadaic acid also stimulated the response to heat stress of the expression of alphaB crystallin, but they barely stimulated the response to heat stress of hsp27.	Staurosporine	144-157	heat shock protein family B (small) member 1	Homo sapiens	356-361
7653654-4	1995	Renal pelvic perfusion with the PKC inhibitors calphostin C (1 microM), staurosporine (20 nM), and H-7 (40 microM) reduced the ARNA responses to bradykinin (20 microM) by 69 +/- 10, 76 +/- 10, and 77 +/- 10%, respectively (all P &lt; 0.01).	Staurosporine	72-85	protein kinase C, gamma	Rattus norvegicus	32-35
8554927-9	1995	The latter effect was specific, since it was reversed by treatment with the PKC inhibitors staurosporine and chelerythrine.	Staurosporine	91-104	protein kinase C alpha	Homo sapiens	76-79
8588973-6	1995	Prior treatment with staurosporine (1 microM), a PKC inhibitor, inhibited the effect of PMA on the BK-induced response, suggesting that the effect of PMA is mediated by the activation of PKC.	Staurosporine	21-34	kininogen 1	Canis lupus familiaris	99-101
8580367-1	1995	The protein kinase C (PKC) inhibitors bisindolylmaleimide, calphostin C, H-7 and staurosporine were examined for their effect on tumour necrosis factor (TNF) cytotoxic activity.	Staurosporine	81-94	tumor necrosis factor	Homo sapiens	129-151
8580367-1	1995	The protein kinase C (PKC) inhibitors bisindolylmaleimide, calphostin C, H-7 and staurosporine were examined for their effect on tumour necrosis factor (TNF) cytotoxic activity.	Staurosporine	81-94	tumor necrosis factor	Homo sapiens	153-156
8567845-7	1995	The effect of PGE2 on PGF2 alpha production is inhibited by staurosporin and this inhibition was reversed by addition of arachidonic acid indicating that protein kinase C is involved in phospholipase A2 activation.	Staurosporine	60-72	prostaglandin F synthase 2	Bos taurus	22-26
8567845-7	1995	The effect of PGE2 on PGF2 alpha production is inhibited by staurosporin and this inhibition was reversed by addition of arachidonic acid indicating that protein kinase C is involved in phospholipase A2 activation.	Staurosporine	60-72	phospholipase A2 group IB	Homo sapiens	186-202
7615516-0	1995	Cyclic AMP-independent up-regulation of the human serotonin transporter by staurosporine in choriocarcinoma cells.	Staurosporine	75-88	solute carrier family 6 member 4	Homo sapiens	50-71
7615516-10	1995	It is concluded that staurosporine up-regulates the serotonin transport activity in JAR cells by increasing the steady state levels of the serotonin transporter mRNA and by the consequent increase in the transporter density in the plasma membrane and that the process involves a cAMP-independent signaling pathway.	Staurosporine	21-34	solute carrier family 6 member 4	Homo sapiens	139-160
7608556-7	1995	IL-1 effects were not reduced by the protein kinase C inhibitor staurosporine or by the protein kinase A inhibitor H89 but blocked by the protein tyrosine kinase inhibitor herbimycin A.	Staurosporine	64-77	interleukin 1 alpha	Homo sapiens	0-4
8904315-7	1995	The effect of cycloheximide on ICAM-1 mRNA was markedly suppressed by serine/threonine (ser/thr) kinase inhibitors, H-7 and staurosporine, whereas the ser/thr phosphatase inhibitor, okadaic acid, augmented the cycloheximide effect.	Staurosporine	124-137	intercellular adhesion molecule 1	Mus musculus	31-37
7547506-4	1995	Furthermore, PKC inhibitors, such as staurosporine or calphostin C, prevent TPA-induced differentiation but not cell growth arrest.	Staurosporine	37-50	protein kinase C alpha	Homo sapiens	13-16
7602115-2	1995	TGF-beta 1-induced JE/MCP-1 gene expression in the cells was inhibited markedly by H-7 (1-(5-isoguinolinesulfonyl)-2-O-methylpiperazine-dihydrochloride) and staurosporine, potent inhibitors of protein kinase.	Staurosporine	157-170	transforming growth factor, beta 1	Mus musculus	0-10
7580750-2	1995	Using the PKC inhibitor, staurosporine we showed that PKC in the region pf the basal membrane suppressed vasopressin-stimulated water transport, whereas PKC in the apical region potentiated this transport.	Staurosporine	25-38	arginine vasopressin	Homo sapiens	105-116
7648427-9	1995	In cells cultured directly on collagen I, staurosporine, quercetin and 6-dimethylaminopurine strongly inhibited prolactin action of alpha S1-casein gene whereas herbimycin A was only partly inhibitory.	Staurosporine	42-55	alpha-S1-casein	Oryctolagus cuniculus	132-147
7602115-2	1995	TGF-beta 1-induced JE/MCP-1 gene expression in the cells was inhibited markedly by H-7 (1-(5-isoguinolinesulfonyl)-2-O-methylpiperazine-dihydrochloride) and staurosporine, potent inhibitors of protein kinase.	Staurosporine	157-170	chemokine (C-C motif) ligand 2	Mus musculus	22-27
7602115-3	1995	TGF-beta 1-induced expression of both early proto-oncogenes c-fos and c-jun in the cells was also inhibited by H-7 and staurosporine.	Staurosporine	119-132	transforming growth factor, beta 1	Mus musculus	0-10
7602115-3	1995	TGF-beta 1-induced expression of both early proto-oncogenes c-fos and c-jun in the cells was also inhibited by H-7 and staurosporine.	Staurosporine	119-132	FBJ osteosarcoma oncogene	Mus musculus	60-65
7602115-3	1995	TGF-beta 1-induced expression of both early proto-oncogenes c-fos and c-jun in the cells was also inhibited by H-7 and staurosporine.	Staurosporine	119-132	jun proto-oncogene	Mus musculus	70-75
7790851-4	1995	At the intracellular level, coactivation of protein kinases A and C mediates the glutamate-dependent stimulation of c-fos expression evoked by VIP, because either H-89 or staurosporin inhibits the effect of VIP as well as that of glutamate.	Staurosporine	171-183	FBJ osteosarcoma oncogene	Mus musculus	116-121
7790851-4	1995	At the intracellular level, coactivation of protein kinases A and C mediates the glutamate-dependent stimulation of c-fos expression evoked by VIP, because either H-89 or staurosporin inhibits the effect of VIP as well as that of glutamate.	Staurosporine	171-183	vasoactive intestinal polypeptide	Mus musculus	143-146
7790851-4	1995	At the intracellular level, coactivation of protein kinases A and C mediates the glutamate-dependent stimulation of c-fos expression evoked by VIP, because either H-89 or staurosporin inhibits the effect of VIP as well as that of glutamate.	Staurosporine	171-183	vasoactive intestinal polypeptide	Mus musculus	207-210
7759887-9	1995	STSN and polymyxin B potently inhibited taxol-induced TNF-alpha secretion and TNF-alpha gene expression as well as iNOS gene expression by rIFN-gamma plus taxol.	Staurosporine	0-4	tumor necrosis factor	Mus musculus	54-63
8588070-3	1995	Application of IL-1 alpha augmented the production of PGF2 alpha at 4 h. Coapplication of H-7 (10-1000 microM) and staurosporine (0.1-10 microM), inhibitors of protein kinase C (PKC), blocked IL-1 alpha-induced PGF2 alpha production.	Staurosporine	115-128	interleukin 1 alpha	Homo sapiens	15-25
7759887-6	1995	STSN and polymyxin B decreased NO synthesis, which had been induced by rIFN-gamma plus taxol.	Staurosporine	0-4	interferon gamma	Rattus norvegicus	71-81
15714752-7	1995	Staurosporine, a non-selective inhibitor of protein kinases, inhibited platelet aggregation induced by thrombin or SFLLRN in all species.	Staurosporine	0-13	coagulation factor II, thrombin	Homo sapiens	103-111
15714752-8	1995	Staurosporine inhibited thrombin-induced [Ca2+]i in guinea pigs, had no effect in rat, and increased [Ca2+]i in all other species.	Staurosporine	0-13	coagulation factor II, thrombin	Homo sapiens	24-32
7775410-5	1995	Staurosporin and Calphostin C, inhibitors of PKC, block the ability of TGF-beta 1 to initiate transcription of the luciferase gene.	Staurosporine	0-12	proline rich transmembrane protein 2	Homo sapiens	45-48
7775410-5	1995	Staurosporin and Calphostin C, inhibitors of PKC, block the ability of TGF-beta 1 to initiate transcription of the luciferase gene.	Staurosporine	0-12	transforming growth factor beta 1	Homo sapiens	71-81
7675309-4	1995	Insulin potentiation of NR1a/NR2A receptor responses was significantly blocked by staurosporine, suggesting kinase involvement in insulin action.	Staurosporine	82-95	insulin S homeolog	Xenopus laevis	0-7
7675309-4	1995	Insulin potentiation of NR1a/NR2A receptor responses was significantly blocked by staurosporine, suggesting kinase involvement in insulin action.	Staurosporine	82-95	nodal homolog 1 L homeolog	Xenopus laevis	24-28
7675309-4	1995	Insulin potentiation of NR1a/NR2A receptor responses was significantly blocked by staurosporine, suggesting kinase involvement in insulin action.	Staurosporine	82-95	glutamate receptor, ionotropic, N-methyl D-aspartate 2A L homeolog	Xenopus laevis	29-33
7675309-4	1995	Insulin potentiation of NR1a/NR2A receptor responses was significantly blocked by staurosporine, suggesting kinase involvement in insulin action.	Staurosporine	82-95	insulin S homeolog	Xenopus laevis	130-137
7766427-7	1995	Activation of eosinophils by the addition of PAF to the lower chamber produced a significant increase in the eosinophil penetration (6.5% at 10(-6) M), which was inhibited by staurosporine.	Staurosporine	175-188	PCNA clamp associated factor	Homo sapiens	45-48
7766427-10	1995	Supernatant from eosinophils activated by PAF (10(-6) M) significantly increased the permeability (451% of controls), which was blocked by staurosporine.	Staurosporine	139-152	PCNA clamp associated factor	Homo sapiens	42-45
7788015-4	1995	Epidermal growth factor (EGF) and 12-O-tetradecanoylphorbol-13-acetate (TPA) dose dependently stimulated thyroid cell proliferation, which could be inhibited by staurosporin (0.1-10 nmol/l).	Staurosporine	161-173	epidermal growth factor	Homo sapiens	0-23
7590896-3	1995	Oxyradical production is one of the lytic mechanisms used by phagocytes, and IL-8 is shown to activate this function, which does not occur if neutrophils are pretreated with the protein kinase C inhibitor, staurosporine, but is increased by R59022, a dyacylglycerol kinase inhibitor.	Staurosporine	206-219	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
8529043-5	1995	These effects was blocked by PKC inhibitor staurosporine, but not by IP20.	Staurosporine	43-56	protein kinase C, gamma	Rattus norvegicus	29-32
7775599-7	1995	The protein kinase C inhibitor staurosporine blocked the survival effect of TPA and IGF-1 in a dose-dependent manner, however did not affect the survival effect of ATA.	Staurosporine	31-44	insulin like growth factor 1	Homo sapiens	84-89
7541052-1	1995	Substance P (SP) and lipopolysaccharide (LPS) stimulated interleukin-6 (IL-6) gene expression, as well as IL-6 protein secretion in the human astrocytoma cell line U373 MG. Staurosporine, an inhibitor of protein kinase C (PKC), entirely blocked SP- but not LPS-induced IL-6 release.	Staurosporine	173-186	tachykinin precursor 1	Homo sapiens	0-11
7541052-1	1995	Substance P (SP) and lipopolysaccharide (LPS) stimulated interleukin-6 (IL-6) gene expression, as well as IL-6 protein secretion in the human astrocytoma cell line U373 MG. Staurosporine, an inhibitor of protein kinase C (PKC), entirely blocked SP- but not LPS-induced IL-6 release.	Staurosporine	173-186	tachykinin precursor 1	Homo sapiens	13-15
7539258-5	1995	The tyrosine kinase inhibitor genistein and the protein kinase C inhibitors staurosporine and Ro31-7549, all blocked bradykinin-induced tyrosine phosphorylation.	Staurosporine	76-89	kininogen 1	Homo sapiens	117-127
7565648-6	1995	The increase of Ca(2+)-ATPase activity in regenerating liver was clearly inhibited by the presence of trifluoperazine (10 microM), staurosporine (2.5 microM) and dibucaine (10 microM), which are inhibitors of calmodulin and protein kinase, in the enzyme reaction mixture.	Staurosporine	131-144	calmodulin 1	Rattus norvegicus	209-219
7720665-4	1995	The protein synthesis inhibitor cycloheximide, as well as two inhibitors of protein kinase C, staurosporine and sangivamycin, prevented the bFGF induction of collagenase transcripts, whereas indomethacin, an inhibitor of prostaglandin synthesis, decreased the effect of bFGF on collagenase mRNA levels by about 50%.	Staurosporine	94-107	fibroblast growth factor 2	Rattus norvegicus	140-144
7768359-4	1995	The activity of both DNases was greatly induced in CTLL2 cells deprived of IL-2 or treated with the kinase inhibitor staurosporine.	Staurosporine	117-130	interleukin 2	Mus musculus	75-79
7722306-6	1995	Induction of NF-IL-4-gamma 1 is inhibited by the kinase inhibitor staurosporine and the factor itself requires phosphorylation for binding activity.	Staurosporine	66-79	interleukin 4	Mus musculus	16-20
7722482-2	1995	The blockade of protein kinase C catalytic domain, by staurosporine, as well as the desensitization of protein kinase C by short-term phorbol 12-myristate 13-acetate pretreatment, increased the basal release of interleukin 6 by rat cortical astrocytes, whereas calphostin C, an antagonist of phorbol ester binding on protein kinase C regulatory domain, did not affect the basal release of the cytokine.	Staurosporine	54-67	interleukin 6	Rattus norvegicus	211-224
7722482-4	1995	This stimulatory action of phorbol 12-myristate 13-acetate was significantly reduced by staurosporine, by calphostin C and by the desensitization of protein kinase C. Interleukin 1 beta increased interleukin 6 release in a concentration-related manner.	Staurosporine	88-101	interleukin 1 beta	Rattus norvegicus	167-185
7722482-7	1995	In conclusion, our data show that in rat cortical astrocytes the basal release of interleukin 6 is under a tonic inhibition exerted by a protein kinase C isoform or isoforms sensitive to blockade by staurosporine and desensitization but insensitive to calphostin C.	Staurosporine	199-212	interleukin 6	Rattus norvegicus	82-95
7537223-4	1995	Staurosporine and chelerythrine, which act on the catalytic domain of PKC, did not allow the attribution of a role for PKC in PLD activation.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	70-73
7796171-9	1995	PKC activation plays a role in hypoxic damage, since PKC down-regulation (by overnight exposure to PMA) or inhibition (with chelerythrine or staurosporine) conferred protection against KCN-induced cytotoxicity.	Staurosporine	141-154	protein kinase C, gamma	Rattus norvegicus	0-3
7749865-7	1995	The protein kinase C inhibitor staurosporine suppressed the effect of PDGF-BB on LPL activity.	Staurosporine	31-44	lipoprotein lipase	Homo sapiens	81-84
7710931-1	1995	Inhibitors of protein kinase C (PKC) such as the staurosporine analogues UCN-01 and CGP 41251 possess antineoplastic properties, but the mechanism of their cytostatic action is not understood.	Staurosporine	49-62	protein kinase C alpha	Homo sapiens	32-35
7710931-11	1995	Staurosporine is not only a strong inhibitor of PKC but also mimics activators of this enzyme in that it elicits the cellular redistribution of certain PKC isoenzymes.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	48-51
7710931-11	1995	Staurosporine is not only a strong inhibitor of PKC but also mimics activators of this enzyme in that it elicits the cellular redistribution of certain PKC isoenzymes.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	152-155
7628704-1	1995	We report the genetic and biochemical properties of a staurosporine (ST)- and temperature-sensitive mutant, stt10, of Saccharomyces cerevisiae.	Staurosporine	54-67	Vps45p	Saccharomyces cerevisiae S288C	108-113
7628704-1	1995	We report the genetic and biochemical properties of a staurosporine (ST)- and temperature-sensitive mutant, stt10, of Saccharomyces cerevisiae.	Staurosporine	69-71	Vps45p	Saccharomyces cerevisiae S288C	108-113
7607538-4	1995	Constitutive expression of xR11 in cultured rat fibroblast (Rat-1) cells conferred a strong protection against cell death induced by the cytotoxic agents staurosporine and cycloheximide, by serum deprivation and specific deregulation of c-myc.	Staurosporine	154-167	BCL2 like 1 S homeolog	Xenopus laevis	27-31
7539427-5	1995	The increase in tyrosine phosphorylation of PKC delta was blocked by tyrosine kinase inhibitors genistein and staurosporine.	Staurosporine	110-123	protein kinase C delta	Homo sapiens	44-53
7768923-7	1995	The Vav-associated GEF activation could be inhibited by staurosporine and calphostin, but not herbimycin, suggesting a modulatory role for phosphorylation at serine-threonine residues.	Staurosporine	56-69	vav guanine nucleotide exchange factor 1	Homo sapiens	4-7
7768923-7	1995	The Vav-associated GEF activation could be inhibited by staurosporine and calphostin, but not herbimycin, suggesting a modulatory role for phosphorylation at serine-threonine residues.	Staurosporine	56-69	Ras protein specific guanine nucleotide releasing factor 1	Homo sapiens	19-22
7796894-6	1995	The protein kinase inhibitor staurosporine prevents the protective effects of IL-2, PMA, and IL-4 on apoptosis and intracellular acidification.	Staurosporine	29-42	interleukin 2	Mus musculus	78-82
7796894-6	1995	The protein kinase inhibitor staurosporine prevents the protective effects of IL-2, PMA, and IL-4 on apoptosis and intracellular acidification.	Staurosporine	29-42	interleukin 4	Mus musculus	93-97
7643856-5	1995	Pretreatment of A20 cells with the PKC inhibitors, staurosporine or chelerythrine chloride, for 5 or 20 min prior to addition of TPA, decreased Ii mRNA levels when compared to cells treated with TPA alone.	Staurosporine	51-64	protein kinase C, alpha	Mus musculus	35-38
7643856-8	1995	Constitutive expression of Ii mRNA was decreased by treatment with staurosporine but not chelerythrine chloride or calphostin C, suggesting that non-PKC protein kinases may also be important for maintaining high levels of Ii mRNA in these cells.	Staurosporine	67-80	protein kinase C, alpha	Mus musculus	149-152
7781766-5	1995	Although treatment of cells with GF109203X or H-89 alone did not alter the constitutive expression of TfR mRNA, incubation of cells with 30-100 nM staurosporine, a wide-spectrum protein kinase inhibitor, resulted in suppression of the constitutive expression of TfR mRNA in a dose-dependent manner.	Staurosporine	147-160	transferrin receptor	Homo sapiens	262-265
7781766-6	1995	These results suggest that (i) the down-regulation of TfR mRNA expression during the differentiation of HL-60 cells can be mediated by activation of either PKC or PKA; (ii) the constitutive expression of TfR mRNA in proliferating HL-60 cells is staurosporine-sensitive and is probably maintained by protein kinase(s) other than PKC and PKA.	Staurosporine	245-258	transferrin receptor	Homo sapiens	54-57
7781766-6	1995	These results suggest that (i) the down-regulation of TfR mRNA expression during the differentiation of HL-60 cells can be mediated by activation of either PKC or PKA; (ii) the constitutive expression of TfR mRNA in proliferating HL-60 cells is staurosporine-sensitive and is probably maintained by protein kinase(s) other than PKC and PKA.	Staurosporine	245-258	transferrin receptor	Homo sapiens	204-207
7741743-7	1995	U-73122, an inhibitor of phospholipase C and staurosporine, an inhibitor of protein kinase C, both decreased the heat-shock-induced phosphorylation of P-glycoprotein.	Staurosporine	45-58	ATP binding cassette subfamily B member 1	Homo sapiens	151-165
7721866-7	1995	MPT4 was isolated in a screen for multicopy suppressors of staurosporine sensitivity in POP2 cells.	Staurosporine	59-72	Stm1p	Saccharomyces cerevisiae S288C	0-4
7721866-7	1995	MPT4 was isolated in a screen for multicopy suppressors of staurosporine sensitivity in POP2 cells.	Staurosporine	59-72	CCR4-NOT core DEDD family RNase subunit POP2	Saccharomyces cerevisiae S288C	88-92
7535813-6	1995	Staurosporine inhibits freshly isolated T lymphocyte chemotaxis toward IL-8, whereas tyrphostin 23 inhibits chemotaxis of overnight cultured and anti-CD3-activated T lymphocytes toward IL-1 alpha.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	71-75
7537105-7	1995	H-7, a protein kinase C inhibitor, did not inhibit the 64 kDa PTP, while staurosporine, a potent protein kinase inhibitor, inhibited the 64 kDa PTP and Ca2+ influx, but not aggregation, in a dose-dependent manner.	Staurosporine	73-86	protein tyrosine phosphatase receptor type U	Homo sapiens	144-147
7536688-0	1995	Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors.	Staurosporine	87-100	proline rich transmembrane protein 2	Homo sapiens	58-74
7536688-1	1995	The hypothesis was tested that 9 kinase inhibitors with diverse specificities for protein kinase C (PKC), including staurosporine and four of its analogues, interfere differently with PKC derived from either the cytosolic or particulate fractions of MCF-7 breast carcinoma cells.	Staurosporine	116-129	proline rich transmembrane protein 2	Homo sapiens	184-187
7536413-3	1995	The protein kinase C-selective inhibitors chelerythrine, staurosporine and calphostin C acted as potent inhibitors of the desensitization process but with various degrees of selectivity regarding their ability to inhibit the desensitizing actions of glucagon and vasopressin.	Staurosporine	57-70	arginine vasopressin	Rattus norvegicus	263-274
7750120-6	1995	Staurosporine (2-50 nM), which has been reported to augment the effects of TNF alpha, was less effective than tamoxifen against WITG3 and, in addition, was markedly inhibitory to non-neoplastic glial cells.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	75-84
7744032-3	1995	The level of mRNA for GST Mu was also decreased, but the mRNAs of c-jun and jun-B were elevated after 2 h. The decrease of GST alpha mRNAs was inhibited by staurosporine, suggesting an involvement of protein kinase C. Inhibition of transcription and translation by actinomycin D and cycloheximide also partially inhibited the effect of TPA on the expression of GST alpha.	Staurosporine	156-169	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
7744032-3	1995	The level of mRNA for GST Mu was also decreased, but the mRNAs of c-jun and jun-B were elevated after 2 h. The decrease of GST alpha mRNAs was inhibited by staurosporine, suggesting an involvement of protein kinase C. Inhibition of transcription and translation by actinomycin D and cycloheximide also partially inhibited the effect of TPA on the expression of GST alpha.	Staurosporine	156-169	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	76-81
7615646-4	1995	The protein kinase C (PKC) inhibitors, H-7, staurosporine, and calphostin C, reversed the rhIL-1 beta induction of TIMP-1 mRNA.	Staurosporine	44-57	TIMP metallopeptidase inhibitor 1	Homo sapiens	115-121
7615646-10	1995	Staurosporine, calphostin C, H-7, and substances that elevate cellular levels of cAMP, like PGE2, also reduced basal expression and synthesis of TIMP-1.	Staurosporine	0-13	TIMP metallopeptidase inhibitor 1	Homo sapiens	145-151
7627804-9	1995	Both orthovanadate and staurosporine inhibited the IFN-alpha production and did not relieve the ConA-mediated inhibition.	Staurosporine	23-36	interferon alpha 1	Homo sapiens	51-60
7759887-9	1995	STSN and polymyxin B potently inhibited taxol-induced TNF-alpha secretion and TNF-alpha gene expression as well as iNOS gene expression by rIFN-gamma plus taxol.	Staurosporine	0-4	tumor necrosis factor	Mus musculus	78-87
7759887-9	1995	STSN and polymyxin B potently inhibited taxol-induced TNF-alpha secretion and TNF-alpha gene expression as well as iNOS gene expression by rIFN-gamma plus taxol.	Staurosporine	0-4	interferon gamma	Rattus norvegicus	139-149
7535772-6	1995	Northern and Western blots indicate that the staurosporine response mainly results from a substantial up-regulation in EGF receptor synthesis, thus providing a much stronger cell surface signal and supporting the view that quantitative rather than qualitative differences distinguish the EGF versus NGF/FGF signaling pathways in these cells.	Staurosporine	45-58	nerve growth factor	Rattus norvegicus	299-302
7783402-8	1995	This effect was reversed by preincubating the cells with the PKC inhibitor staurosporine.	Staurosporine	75-88	proline rich transmembrane protein 2	Homo sapiens	61-64
7778066-6	1995	The pHi-stimulating effect of endothelin-1 was inhibited by 10(-7) M staurosporine, calphostin C and 5-(N,N-hexamethylene) amiloride.	Staurosporine	69-82	glucose-6-phosphate isomerase	Homo sapiens	4-7
7778066-6	1995	The pHi-stimulating effect of endothelin-1 was inhibited by 10(-7) M staurosporine, calphostin C and 5-(N,N-hexamethylene) amiloride.	Staurosporine	69-82	endothelin 1	Homo sapiens	30-42
7720702-6	1995	MARCKS phosphorylation is required for its translocation to lysosomes since mutating either the serine residues phosphorylated by PKC (phos-) or the PKC inhibitor staurosporine, prevented MARCKS phosphorylation, its release from the plasma membrane, and its subsequent association with lysosomes.	Staurosporine	163-176	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
7720702-6	1995	MARCKS phosphorylation is required for its translocation to lysosomes since mutating either the serine residues phosphorylated by PKC (phos-) or the PKC inhibitor staurosporine, prevented MARCKS phosphorylation, its release from the plasma membrane, and its subsequent association with lysosomes.	Staurosporine	163-176	proline rich transmembrane protein 2	Homo sapiens	149-152
7880829-7	1995	In the presence of both H-7 (200 microM) and staurosporine (200 nM) the phosphorylation of P190 is completely blocked.	Staurosporine	45-58	contactin associated protein 1	Homo sapiens	91-95
7534999-5	1995	In the isolated rat lung, the inhibitory effects of staurosporine on pulmonary pressor responses were investigated and injections of angiotensin II, NE, and serotonin produced dose-related increases in pulmonary arterial perfusion pressure that were decreased after administration of 20 micrograms ia of the PKC inhibitor staurosporine.	Staurosporine	52-65	angiotensinogen	Rattus norvegicus	133-147
7887922-3	1995	Using an AhR antagonist, alpha-naphthoflavone (alpha-NF) and a protein kinase C (PKC) inhibitor, staurosporine (ST), in the Hep G2 cell line, the induced CYP1A1 activity was modulated in the same manner as when the cells were coexposed to TCDD and either alpha-NF or ST.	Staurosporine	97-110	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	154-160
7887922-3	1995	Using an AhR antagonist, alpha-naphthoflavone (alpha-NF) and a protein kinase C (PKC) inhibitor, staurosporine (ST), in the Hep G2 cell line, the induced CYP1A1 activity was modulated in the same manner as when the cells were coexposed to TCDD and either alpha-NF or ST.	Staurosporine	112-114	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	154-160
7534980-2	1995	We now report that the PKC inhibitor staurosporine upregulates whole cell Cl- currents isosmotically.	Staurosporine	37-50	proline rich transmembrane protein 2	Homo sapiens	23-26
7900784-3	1995	This effect of ANG II (10(-7) M) is via AT1 receptors and protein kinase C (PKC), since it was inhibited by losartan (10(-6) M) and staurosporine (10(-6) M), respectively.	Staurosporine	132-145	angiotensinogen	Rattus norvegicus	15-21
7900784-3	1995	This effect of ANG II (10(-7) M) is via AT1 receptors and protein kinase C (PKC), since it was inhibited by losartan (10(-6) M) and staurosporine (10(-6) M), respectively.	Staurosporine	132-145	angiotensin II receptor, type 1a	Rattus norvegicus	40-43
7621533-3	1995	The effect of TPA was abolished by the down-regulation procedure and by protein kinase C inhibitors, such as staurosporine (100 nM), suramin (100 microM), and sphingosine (100 microM), pointing to a role of protein kinase C (PKC) in this process.	Staurosporine	109-122	plasminogen activator, tissue type	Homo sapiens	14-17
7875467-6	1995	Activation of PKC by phorbol myristate acetate also stimulated IL-8 production; however, the effects of IL-1 beta or TNF-alpha did not require PKC, as shown by the PKC inhibitor staurosporin or PKC depletion.	Staurosporine	178-190	proline rich transmembrane protein 2	Homo sapiens	14-17
7533140-3	1995	The PKC inhibitor staurosporine (10 to 100 nmol/L) increased the expression of ecNOS mRNA, assessed by Northern analysis, in a dose-dependent manner.	Staurosporine	18-31	nitric oxide synthase 3	Bos taurus	79-84
7533140-6	1995	The protein content of ecNOS, assessed by Western analysis, was also increased in staurosporine-treated or chelerythrine-treated BAEC.	Staurosporine	82-95	nitric oxide synthase 3	Bos taurus	23-28
7860643-11	1995	The role of protein kinase C (PKC) in the EGF-stimulated ERK signaling pathway was further examined by inhibition of PKC with the staurosporine analog, CGP41251, and by down-regulation of PKC via chronic treatment with PMA.	Staurosporine	130-143	epidermal growth factor	Homo sapiens	42-45
7860643-11	1995	The role of protein kinase C (PKC) in the EGF-stimulated ERK signaling pathway was further examined by inhibition of PKC with the staurosporine analog, CGP41251, and by down-regulation of PKC via chronic treatment with PMA.	Staurosporine	130-143	mitogen-activated protein kinase 1	Homo sapiens	57-60
7772573-7	1995	A 20-min pretreatment with PKC inhibitors, H-7 or staurosporine, reversed the decrease by PMA in the shoulder of BK-induced Ca2+ response.	Staurosporine	50-63	proline rich transmembrane protein 2	Homo sapiens	27-30
7772573-7	1995	A 20-min pretreatment with PKC inhibitors, H-7 or staurosporine, reversed the decrease by PMA in the shoulder of BK-induced Ca2+ response.	Staurosporine	50-63	kininogen 1	Homo sapiens	113-115
7857980-2	1995	Nonspecific inhibition of protein kinases with H7 or staurosporine markedly decreases Kv1.5 K+ channel gene transcription and mRNA without producing a substantial change in Kv1.4 mRNA.	Staurosporine	53-66	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	86-91
7857264-2	1995	The effects of SNOC on IsK could not be prevented by the guanylate cyclase inhibitor LY-83,583 and the cGMP kinase inhibitor H8, but was abolished in the presence of staurosporine.	Staurosporine	166-179	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	23-26
7857264-4	1995	These data suggest that the NO-donor SNOC regulates IsK indirectly via a cGMP independent, but staurosporine sensitive, pathway.	Staurosporine	95-108	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	52-55
7864148-3	1995	Increases in G and Isc induced by oxidants were significantly inhibited by catalase (1,000 U/ml) and the protein kinase C inhibitor staurosporine (10(-7) M), but superoxide dismutase (SOD; 100 U/ml) was without effect.	Staurosporine	132-145	superoxide dismutase 1	Homo sapiens	184-187
7864174-10	1995	Staurosporine abolished the TPA effect and partially inhibited that of PTH.	Staurosporine	0-13	parathyroid hormone	Rattus norvegicus	71-74
7736562-6	1995	Prior treatment of TSMCs with staurosporine (1 microM), a PKC inhibitor, inhibited the ability of PMA to attenuate ET-1-induced responses, suggesting that the inhibitory effect of PMA is mediated through the activation of PKC.	Staurosporine	30-43	endothelin 1	Canis lupus familiaris	115-119
7540056-2	1995	We confirmed the PKC dependence of TNF-alpha and NO productions and found that Gel B was inhibited by Calphostin C (CAL), but potentiated by staurosporine (STAR) and CGP 41 251.	Staurosporine	141-154	matrix metallopeptidase 9	Mus musculus	79-84
7835292-10	1995	The TPA-mitogenic and antimitogenic effects could not be mimicked by 4 alpha-phorbol-12,13-didecanoate and were reversed by staurosporine, thus indicating a PKC-mediated pathway for such TPA actions.	Staurosporine	124-137	proline rich transmembrane protein 2	Homo sapiens	157-160
7835303-6	1995	Pretreatment of MC3T3-E1 cells with staurosporine, an inhibitor of PKC, resulted in an approximately 3-fold increase in basal VDR levels but did not enhance the PTH-mediated up-regulation of VDR.	Staurosporine	36-49	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	126-129
21153153-0	1995	Effects of phorbol ester and staurosporine on the actions of insulin-like growth factor-I on rat ovarian granulosa cells.	Staurosporine	29-42	insulin-like growth factor 1	Rattus norvegicus	61-89
21153153-5	1995	In this study, the effects of phorbol 12-myristate 13-acetate (PMA, a PKC activator) and staurosporine (ST, a PKC inhibitor) on IGF-I action were studied using immature rat ovarian granulosa cells.	Staurosporine	89-102	insulin-like growth factor 1	Rattus norvegicus	128-133
21153153-5	1995	In this study, the effects of phorbol 12-myristate 13-acetate (PMA, a PKC activator) and staurosporine (ST, a PKC inhibitor) on IGF-I action were studied using immature rat ovarian granulosa cells.	Staurosporine	104-106	insulin-like growth factor 1	Rattus norvegicus	128-133
21153153-18	1995	Thus, it is likely that ST induces granulosa cell steroidogenesis, potentiates the IGF-I stimulation of steroidogenesis and regulates IGFBP via both PKC-dependent and -independent pathways.	Staurosporine	24-26	insulin-like growth factor 1	Rattus norvegicus	83-88
7769002-3	1995	In this study, we have characterized a novel gene, pad1+, which was isolated as a multicopy plasmid capable of conferring staurosporine-resistance.	Staurosporine	122-135	Protein pad-1	Caenorhabditis elegans	51-55
7480798-0	1995	Interleukin-1 beta-stimulated prostaglandin synthesis by human decidual cells is independent of protein kinase C. Basal prostaglandin E2 (PGE2) synthesis by human decidual cells was stimulated by phorbol myristate acetate (PMA) which activates protein kinase C. Staurosporine, which is an inhibitor of protein kinase C in most systems, also increased basal PGE2 synthesis.	Staurosporine	262-275	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Staurosporine	101-114	interleukin 1 beta	Homo sapiens	0-18
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Staurosporine	101-114	interleukin 1 beta	Homo sapiens	20-29
7480798-2	1995	Interleukin-1 beta (IL-1 beta)-stimulated PGE2 synthesis was potentiated by coincubation with PMA or staurosporine, indicating that IL-1 beta and protein kinase C increase decidual PGE2 synthesis through different mechanisms.	Staurosporine	101-114	interleukin 1 beta	Homo sapiens	132-141
7834747-3	1995	In gene transfer experiments using a human lymphoid cell line, Jurkat, coexpression of BAG-1 and Bcl-2 provided markedly increased protection from cell death induced by several stimuli, including staurosporine, anti-Fas antibody, and cytolytic T cells, relative to cells that contained gene transfer-mediated elevations in either BAG-1 or Bcl-2 protein alone.	Staurosporine	196-209	BAG cochaperone 1	Homo sapiens	87-92
7834747-3	1995	In gene transfer experiments using a human lymphoid cell line, Jurkat, coexpression of BAG-1 and Bcl-2 provided markedly increased protection from cell death induced by several stimuli, including staurosporine, anti-Fas antibody, and cytolytic T cells, relative to cells that contained gene transfer-mediated elevations in either BAG-1 or Bcl-2 protein alone.	Staurosporine	196-209	BCL2 apoptosis regulator	Homo sapiens	97-102
7724045-6	1995	Dialyzing DA neurons with protein kinase C (PKC) inhibitors, staurosporine and PKC(19-31), prevented neurotensin from decreasing the potassium conductance.	Staurosporine	61-74	protein kinase C, gamma	Rattus norvegicus	26-42
7724045-6	1995	Dialyzing DA neurons with protein kinase C (PKC) inhibitors, staurosporine and PKC(19-31), prevented neurotensin from decreasing the potassium conductance.	Staurosporine	61-74	protein kinase C, gamma	Rattus norvegicus	44-47
7724045-6	1995	Dialyzing DA neurons with protein kinase C (PKC) inhibitors, staurosporine and PKC(19-31), prevented neurotensin from decreasing the potassium conductance.	Staurosporine	61-74	neurotensin	Rattus norvegicus	101-112
7851400-8	1995	Studies with several protein kinase inhibitors revealed a novel sensitivity profile of PKC mu, with no inhibition by calphostin C, reduced sensitivity to staurosporine but, compared to other PKCs, an approximately 60-fold higher sensitivity to the selective PKA inhibitor H89.	Staurosporine	154-167	protein kinase D1	Homo sapiens	87-93
7851410-8	1995	Staurosporine slightly enhanced ALP serine and threonine phosphatase activities at a concentration of 0.1 mM.	Staurosporine	0-13	alkaline phosphatase, placental	Homo sapiens	32-35
7840614-4	1995	The results show that MAPK stimulation is transient (peak activity, 30 min) and precedes that of S6K, which reaches a maximum at 1.5-2 h, and slowly returns towards control levels at 6 h. Both staurosporine which inhibits GH receptor-associated kinase (JAK2) and genistein (GEN), an inhibitor of membrane-associated and cytoplasmic TKs, abrogate Prl-stimulated TK, MAPK, and S6K.	Staurosporine	193-206	ribosomal protein S6 kinase B1	Homo sapiens	97-100
7840614-4	1995	The results show that MAPK stimulation is transient (peak activity, 30 min) and precedes that of S6K, which reaches a maximum at 1.5-2 h, and slowly returns towards control levels at 6 h. Both staurosporine which inhibits GH receptor-associated kinase (JAK2) and genistein (GEN), an inhibitor of membrane-associated and cytoplasmic TKs, abrogate Prl-stimulated TK, MAPK, and S6K.	Staurosporine	193-206	Janus kinase 2	Homo sapiens	253-257
7840614-4	1995	The results show that MAPK stimulation is transient (peak activity, 30 min) and precedes that of S6K, which reaches a maximum at 1.5-2 h, and slowly returns towards control levels at 6 h. Both staurosporine which inhibits GH receptor-associated kinase (JAK2) and genistein (GEN), an inhibitor of membrane-associated and cytoplasmic TKs, abrogate Prl-stimulated TK, MAPK, and S6K.	Staurosporine	193-206	prolactin	Homo sapiens	346-349
7840614-4	1995	The results show that MAPK stimulation is transient (peak activity, 30 min) and precedes that of S6K, which reaches a maximum at 1.5-2 h, and slowly returns towards control levels at 6 h. Both staurosporine which inhibits GH receptor-associated kinase (JAK2) and genistein (GEN), an inhibitor of membrane-associated and cytoplasmic TKs, abrogate Prl-stimulated TK, MAPK, and S6K.	Staurosporine	193-206	TXK tyrosine kinase	Homo sapiens	332-334
7840614-4	1995	The results show that MAPK stimulation is transient (peak activity, 30 min) and precedes that of S6K, which reaches a maximum at 1.5-2 h, and slowly returns towards control levels at 6 h. Both staurosporine which inhibits GH receptor-associated kinase (JAK2) and genistein (GEN), an inhibitor of membrane-associated and cytoplasmic TKs, abrogate Prl-stimulated TK, MAPK, and S6K.	Staurosporine	193-206	ribosomal protein S6 kinase B1	Homo sapiens	375-378
7840780-8	1995	In thrombin-stimulated vessels staurosporine only inhibited the tonic phase of the contractile response whereas the increase in IP3 and the phasic component of contraction were still evident.	Staurosporine	31-44	coagulation factor II, thrombin	Homo sapiens	3-11
7717193-1	1995	In the present study, we have shown that the protein kinase C (PKC) inhibition by staurosporine augmented fMet-Leu-Phe-(FMLP)-induced arachidonic acid (AA) release in human polymorph neutrophils (PMN).	Staurosporine	82-95	formyl peptide receptor 1	Homo sapiens	120-124
7741187-10	1995	In addition, CL responses upon stimulation with C5a and PAF were abrogated by cytochalasin B, staurosporine, and wortmannin, and were almost completely blocked by pertussis toxin.	Staurosporine	94-107	complement C5a receptor 1	Homo sapiens	48-51
7741187-10	1995	In addition, CL responses upon stimulation with C5a and PAF were abrogated by cytochalasin B, staurosporine, and wortmannin, and were almost completely blocked by pertussis toxin.	Staurosporine	94-107	PCNA clamp associated factor	Homo sapiens	56-59
7756114-2	1995	Pretreatment of the cells with staurosporine (an inhibitor of PKC) prevents AA release and PLA2 activity caused by H2O2.	Staurosporine	31-44	phospholipase A2	Oryctolagus cuniculus	91-95
7756114-6	1995	Under this condition, staurosporine prevents the stimulatory effects of 4 beta-PMA on membrane PLA2 activity, and AA release.	Staurosporine	22-35	phospholipase A2	Oryctolagus cuniculus	95-99
7705383-4	1995	Total inhibition of the C5a- and PMA-mediated burst could be achieved with the PKC inhibitor staurosporine at concentrations of 100 and 5nM, respectively.	Staurosporine	93-106	complement C5a receptor 1	Homo sapiens	24-27
7813610-7	1995	Contrarily, inhibitory activity of TGF-beta 1 on DNA synthesis was PT-sensitive and staurosporine-insensitive.	Staurosporine	84-97	transforming growth factor beta 1	Homo sapiens	35-45
7889145-11	1995	The H2O2-induced MARCKS phosphorylation was inhibited by the addition of the kinase inhibitors H-7 and staurosporine.	Staurosporine	103-116	myristoylated alanine rich protein kinase C substrate	Homo sapiens	17-23
8553907-8	1995	In addition, treatment of FLC with staurosporine prevented the induction of IFN-stimulated genes and the establishment of the antiviral state only when this drug was used at high dosage (500 nM).	Staurosporine	35-48	interferon alpha 1	Homo sapiens	76-79
7876168-4	1995	LPS-dependent NF-kappa B activation was inhibited by protein kinase inhibitors, such as staurosporine, herbimycin A, tyrphostin, and genistein, but not mitogen-activated protein kinase substrate, cGMP-dependent protein kinase, cAMP-dependent protein kinase, protein kinase C, and calmodulin-dependent protein kinase II inhibitory peptides, suggesting that staurosporine-sensitive kinase(s) as well as tyrosine kinase(s) are involved in LPS-mediated NF-kappa B activation.	Staurosporine	88-101	nuclear factor kappa B subunit 1	Homo sapiens	14-24
8553907-10	1995	The non receptor tyrosine kinases of the JAK family that take part in the IFNs-specific transduction pathways could be the target of the staurosporine specific inhibition of the IFN-alpha action.	Staurosporine	137-150	interferon alpha 1	Homo sapiens	178-187
7707287-6	1995	Moreover, the effect of tamoxifen was not mediated by inhibition of protein kinase C, since the use of staurosporine (a protein kinase inhibitor) resulted in potentiation of phospholipase C activation by oxytocin.	Staurosporine	103-116	oxytocin/neurophysin I prepropeptide	Homo sapiens	204-212
8903945-2	1995	CGP 41251, a derivative of staurosporine with an increased selectivity for protein kinase C (PKC) inhibition, was found to modulate MSH receptors in human D10 and HBL cells and in the mouse B16 cell line.	Staurosporine	27-40	proline rich transmembrane protein 2	Homo sapiens	75-91
8903945-2	1995	CGP 41251, a derivative of staurosporine with an increased selectivity for protein kinase C (PKC) inhibition, was found to modulate MSH receptors in human D10 and HBL cells and in the mouse B16 cell line.	Staurosporine	27-40	proline rich transmembrane protein 2	Homo sapiens	93-96
8903945-2	1995	CGP 41251, a derivative of staurosporine with an increased selectivity for protein kinase C (PKC) inhibition, was found to modulate MSH receptors in human D10 and HBL cells and in the mouse B16 cell line.	Staurosporine	27-40	proopiomelanocortin	Homo sapiens	132-135
7630315-2	1995	Jatrophone, staurosporine and H-7, caused graded inhibition of rat portal vein contractions induced by phorbol 12-myristate 13-acetate (PMA), noradrenaline, endothelin-1 or KCl, with IC50s of 86 nM, 13 microM, 11 microM and 9 microM, respectively.	Staurosporine	12-25	endothelin 1	Rattus norvegicus	157-169
8597871-7	1995	Studies using inhibitors of signal transduction suggest that both receptors mediate NF-kappa B activation via similar routes: D609, an inhibitor of the phospatidylcholine-specific phospholipase C, had an inhibitory effect, while the protein kinase C inhibitor staurosporine had an enhancing effect on both Fas and TNF-R induced NF-kappa B mobilization.	Staurosporine	260-273	nuclear factor kappa B subunit 1	Homo sapiens	84-94
7533872-4	1995	Calphostin and staurosporine, inhibitors of protein kinase C and other serine-threonine protein kinases, block in a dose-dependent manner the effect of angiotensin II and PMA.	Staurosporine	15-28	angiotensinogen	Rattus norvegicus	152-166
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Staurosporine	0-13	intercellular adhesion molecule 1	Homo sapiens	188-221
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Staurosporine	0-13	intercellular adhesion molecule 1	Homo sapiens	223-229
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Staurosporine	0-13	intercellular adhesion molecule 1	Homo sapiens	231-235
7659180-2	1995	Staurosporine, a protein kinase inhibitor with broad profile of inhibitory activity on diverse protein kinases, but not CGP 41,251 substantially inhibited the TPA-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1, CD54) and to a lesser extent also its ligand CD11a.	Staurosporine	0-13	integrin subunit alpha L	Homo sapiens	276-281
8532589-7	1995	The effect of zinc sulfate to enhance the IGF-I-increased alkaline phosphatase activity and protein concentration in the cells was clearly prevented by the presence of cycloheximide (10(-6) M), staurosporin (10(-8) M), or okadaic acid (10(-7) M) with an effective concentration.	Staurosporine	194-206	insulin-like growth factor 1	Mus musculus	42-47
8532589-8	1995	However, staurosporin had a partial inhibiting effect on the IGF-I or the IGF-I plus zinc-induced increases in cellular protein, although okadaic acid entirely blocked the IGF-I or the IGF-I plus zinc effect.	Staurosporine	9-21	insulin-like growth factor 1	Mus musculus	61-66
8532589-8	1995	However, staurosporin had a partial inhibiting effect on the IGF-I or the IGF-I plus zinc-induced increases in cellular protein, although okadaic acid entirely blocked the IGF-I or the IGF-I plus zinc effect.	Staurosporine	9-21	insulin-like growth factor 1	Mus musculus	74-79
8532589-8	1995	However, staurosporin had a partial inhibiting effect on the IGF-I or the IGF-I plus zinc-induced increases in cellular protein, although okadaic acid entirely blocked the IGF-I or the IGF-I plus zinc effect.	Staurosporine	9-21	insulin-like growth factor 1	Mus musculus	74-79
8532589-8	1995	However, staurosporin had a partial inhibiting effect on the IGF-I or the IGF-I plus zinc-induced increases in cellular protein, although okadaic acid entirely blocked the IGF-I or the IGF-I plus zinc effect.	Staurosporine	9-21	insulin-like growth factor 1	Mus musculus	74-79
7983017-9	1994	TRH stimulation of Ca2+ efflux was not reproduced by phorbol esters or inhibited by down-regulation of protein kinase C or staurosporine.	Staurosporine	123-136	thyrotropin releasing hormone	Rattus norvegicus	0-3
7536133-3	1994	Preincubation of day 10 erythroblasts with a broad inhibitor of serine/threonine and tyrosine kinases, staurosporine (100 nM), blocked the increase in [Cai] over 20 min following erythropoietin stimulation.	Staurosporine	103-116	erythropoietin	Homo sapiens	179-193
7700020-8	1994	Pretreatment with PKC antagonists, either 500 microM H-7 or 100 nM staurosporine, prevented the increase of LPO in the glomeruli exposed to HG for one hour but not in glomeruli exposed for 48 hours.	Staurosporine	67-80	protein kinase C, gamma	Rattus norvegicus	18-21
7526152-9	1994	Consistently, downregulation of PKC by chronic phorbol myristate acetate treatment or inhibition of PKC by H7 and staurosporine blocked PDGF- and phorbol myristate acetate- but not EGF-induced signaling and DNA synthesis.	Staurosporine	114-127	protein kinase C, delta	Mus musculus	100-103
7704445-5	1994	Phloretin (250 microM) and staurosporine (20 nM), two protein kinase C inhibitors, inhibited Ca2+ channel activity, thereby suppressing the effect of GnRH.	Staurosporine	27-40	gonadotropin releasing hormone 1	Homo sapiens	150-154
7895916-10	1994	In contrast, the staurosporine inhibited the degradation of hGHR in a dose-dependent manner.	Staurosporine	17-30	growth hormone receptor	Homo sapiens	60-64
11550712-6	1994	The PKC inhibitor, staurosporine, as well as PKC downregulation, were both found to inhibit PMA-induced PLD activity without inhibiting other PMA-induced effects in chondrocytes.	Staurosporine	19-32	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
7972693-0	1994	Increased expression of cyclin B1 mRNA coincides with diminished G2-phase arrest in irradiated HeLa cells treated with staurosporine or caffeine.	Staurosporine	119-132	cyclin B1	Homo sapiens	24-33
7972693-6	1994	Coincident with the reduction in G2-phase delay, we observed an increase in cyclin B1 mRNA accumulation in irradiated, staurosporine-treated cells compared to cells treated with irradiation alone.	Staurosporine	119-132	cyclin B1	Homo sapiens	76-85
7972693-9	1994	The findings that both staurosporine and caffeine treatments reverse the depression in cyclin B1 expression suggest that these two compounds may act on a common pathway of cell cycle control in response to radiation injury.	Staurosporine	23-36	cyclin B1	Homo sapiens	87-96
7961846-5	1994	Staurosporin and calphostin C, two inhibitors of protein kinase C, but not of H8, a protein kinase A inhibitor, were able to block Trx-dependent proliferation.	Staurosporine	0-12	thioredoxin	Homo sapiens	131-134
7954429-0	1994	The kinase inhibitor staurosporine induces G1 arrest at two points: effect on retinoblastoma protein phosphorylation and cyclin-dependent kinase 2 in normal and transformed cells.	Staurosporine	21-34	cyclin dependent kinase 2	Homo sapiens	121-146
7946388-3	1994	This inhibition was reversed when the cells were preincubated with the PKC inhibitor staurosporine for 5 min before the addition of PMA.	Staurosporine	85-98	Prkca	Cavia porcellus	71-74
7977736-7	1994	Staurosporine abolished the effect of TPA, and both staurosporine and calphostin C partially inhibited the effect of PTH.	Staurosporine	52-65	parathyroid hormone	Rattus norvegicus	117-120
7977736-8	1994	Staurosporine and verapamil together produced greater inhibition of PTH action than each alone.	Staurosporine	0-13	parathyroid hormone	Rattus norvegicus	68-71
7525254-8	1994	Similary, staurosporine, calphostin C, guanosine 5"-O-1(2-thiodiphosphate), and pertussis toxin inhibited the effect of PTH on [Ca2+]i of adipocytes.	Staurosporine	10-23	parathyroid hormone	Rattus norvegicus	120-123
7927266-7	1994	The protein kinase C inhibitors staurosporine and calphostin C inhibited arginine vasopressin- and phorbol myristol acetate-induced, but not thapsigargin-induced, intracellular pH recovery.	Staurosporine	32-45	arginine vasopressin	Homo sapiens	82-93
7671126-5	1994	Treatment with PKC inhibitors such as staurosporine or polymyxin B decreased rIFN-gamma-plus-PMA-stimulated NO synthesis.	Staurosporine	38-51	interferon gamma	Rattus norvegicus	77-87
7859925-4	1994	Staurosporine enhanced the ET-1-induced formation of choline.	Staurosporine	0-13	endothelin 1	Mus musculus	27-31
7929422-5	1994	Pretreatment with tyrosine kinase inhibitors including staurosporine and genistein decreased PLD activity by 82.6% and 87.2%, respectively, and completely blocked tyrosine phosphorylation of PDGF receptor and PLC-gamma 1 in 3T3-gamma 1 cells stimulated with PDGF.	Staurosporine	55-68	phospholipase C, gamma 1	Mus musculus	209-220
7929424-3	1994	The PKC inhibitors H-7 and staurosporine, but not the protein kinase A inhibitor HA1004, block not only interleukin-3- and bryostatin-1-induced hyperphosphorylation of Bc12 alpha but also their anti-apoptotic effect on growth factor-dependent cells, suggesting a role for activated PKC in both processes.	Staurosporine	27-40	interleukin 3	Mus musculus	104-117
7923609-8	1994	Moreover, shear stress-induced ET-1 gene expression was inhibited by EGTA, BAPTA/AM, and staurosporine to a degree similar to the inhibition of actin depolymerization.	Staurosporine	89-102	endothelin 1	Homo sapiens	31-35
7989747-10	1994	Herbimycin A, a protein tyrosine kinase inhibitor, and staurosporine, a protein kinase C inhibitor, blocked T cell proliferation induced by CD27 ligation, suggesting the possibility that the activation of protein tyrosine kinase and protein kinase C is required for CD27-mediated T cell costimulation.	Staurosporine	55-68	CD27 molecule	Homo sapiens	140-144
7989747-10	1994	Herbimycin A, a protein tyrosine kinase inhibitor, and staurosporine, a protein kinase C inhibitor, blocked T cell proliferation induced by CD27 ligation, suggesting the possibility that the activation of protein tyrosine kinase and protein kinase C is required for CD27-mediated T cell costimulation.	Staurosporine	55-68	CD27 molecule	Homo sapiens	266-270
7982967-8	1994	The direct PKC activator, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced phosphorylation of Cx43 that was completely blocked by the protein kinase C inhibitor, staurosporine.	Staurosporine	165-178	gap junction protein, alpha 1	Rattus norvegicus	97-101
7810625-7	1994	The PKC inhibitor staurosporine increased basal PRL release and completely reversed the inhibitory effect of ET on PRL release.	Staurosporine	18-31	prolactin	Homo sapiens	48-51
7810625-7	1994	The PKC inhibitor staurosporine increased basal PRL release and completely reversed the inhibitory effect of ET on PRL release.	Staurosporine	18-31	prolactin	Homo sapiens	115-118
7804449-8	1994	The PTH-induced increase in Pi uptake was abolished almost completely by pretreating cells with PKC inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride (H-7) (50 mumol/l) or staurosporin (10 and 50 nmol/l), and by down-regulating PKC with a prolonged TPA treatment.	Staurosporine	197-209	parathyroid hormone	Rattus norvegicus	4-7
7960100-4	1994	The fimbria-induced pp68 was inhibited dramatically by staurosporine, a potent inhibitor of protein kinase C. pp68 induction was also inhibited by H-7, a potent inhibitor of several types of protein kinase.	Staurosporine	55-68	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	20-24
7960100-4	1994	The fimbria-induced pp68 was inhibited dramatically by staurosporine, a potent inhibitor of protein kinase C. pp68 induction was also inhibited by H-7, a potent inhibitor of several types of protein kinase.	Staurosporine	55-68	synaptotagmin binding cytoplasmic RNA interacting protein	Homo sapiens	110-114
8002245-10	1994	Staurosporine pretreatment suppressed HLA-DR expression by IFN-gamma-stimulated RPE cells, but this was not additive with TGF-beta.	Staurosporine	0-13	interferon gamma	Homo sapiens	59-68
8002245-12	1994	The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway.	Staurosporine	72-85	interferon gamma	Homo sapiens	24-33
8002245-12	1994	The modulation of these IFN-gamma and TGF-beta effects by calphostin C, staurosporine, and PMA treatment suggests involvement of the protein kinase C pathway.	Staurosporine	72-85	transforming growth factor beta 1	Homo sapiens	38-46
7700024-8	1994	Inhibition of the intracellular release by preincubating vascular smooth muscle cells with thapsigargin (10(-5) M) also partially inhibited the effect of angiotensin II (Ang II) on [Ca++]n. However, combined EGTA and thapsigargin abolished both the rise in [Ca++]c and the surge in [Ca++]n. The protein kinase C inhibitors staurosporine (5 x 10(-8) M) and H7 (10(-7) M) had no effect on the Ang II-mediated increases in [Ca++]c and [Ca++]n. Our results demonstrate that the angiotensin II-induced increase in [Ca++]c is rapidly followed by a rise in [Ca++]n. This effect on [Ca++]n is not mediated by an angiotensin II-induced generation of IP3 or activation of protein kinases, but rather seems to depend on an increase in [Ca++]c.	Staurosporine	323-336	angiotensinogen	Rattus norvegicus	154-168
7700024-8	1994	Inhibition of the intracellular release by preincubating vascular smooth muscle cells with thapsigargin (10(-5) M) also partially inhibited the effect of angiotensin II (Ang II) on [Ca++]n. However, combined EGTA and thapsigargin abolished both the rise in [Ca++]c and the surge in [Ca++]n. The protein kinase C inhibitors staurosporine (5 x 10(-8) M) and H7 (10(-7) M) had no effect on the Ang II-mediated increases in [Ca++]c and [Ca++]n. Our results demonstrate that the angiotensin II-induced increase in [Ca++]c is rapidly followed by a rise in [Ca++]n. This effect on [Ca++]n is not mediated by an angiotensin II-induced generation of IP3 or activation of protein kinases, but rather seems to depend on an increase in [Ca++]c.	Staurosporine	323-336	angiotensinogen	Rattus norvegicus	170-176
7872662-7	1994	While staurosporine accelerates TGF beta 1-induced apoptosis in both 476-16 and T24 cells, 12-O-tetradecanoylphorbol 13-acetate inhibits TGF beta 1-induced apoptosis of 476-16 cells but stimulates that of T24 cells.	Staurosporine	6-19	transforming growth factor beta 1	Homo sapiens	32-42
7923629-8	1994	To clarify the role of PKC in vasoconstrictor-stimulated VSMC production of bFGF and hypertrophy, PKC was down-regulated by prolonged exposure to PMA or was inhibited with calphostin C or staurosporine before the addition of TXA2 or Ang II.	Staurosporine	188-201	protein kinase C alpha	Homo sapiens	98-101
7531168-7	1994	In contrast, PKC inhibition by staurosporine and calphostin C resulted in increased phagocytosis.	Staurosporine	31-44	proline rich transmembrane protein 2	Homo sapiens	13-16
7859920-7	1994	Furthermore, incubation of hGH- or IL2-induced cells with the potent PKC inhibitor staurosporin (ST) decreased the levels of Nb29 in both hGH- and IL2-induced cells, although the effect of the mitogens differed significantly in their inhibition slopes.	Staurosporine	83-95	interleukin 2	Rattus norvegicus	35-38
7859920-7	1994	Furthermore, incubation of hGH- or IL2-induced cells with the potent PKC inhibitor staurosporin (ST) decreased the levels of Nb29 in both hGH- and IL2-induced cells, although the effect of the mitogens differed significantly in their inhibition slopes.	Staurosporine	83-95	interleukin 2	Rattus norvegicus	147-150
7523496-10	1994	The mechanism by which cross-linking of CD7 or CD16 on NK cells induced adhesion to FN appeared to involve both protein tyrosine kinase and protein kinase C, because this adhesion was blocked in the presence of either genistein or a protein kinase C inhibitor, staurosporin.	Staurosporine	261-273	CD7 molecule	Homo sapiens	40-43
7523496-10	1994	The mechanism by which cross-linking of CD7 or CD16 on NK cells induced adhesion to FN appeared to involve both protein tyrosine kinase and protein kinase C, because this adhesion was blocked in the presence of either genistein or a protein kinase C inhibitor, staurosporin.	Staurosporine	261-273	Fc gamma receptor IIIa	Homo sapiens	47-51
7523496-10	1994	The mechanism by which cross-linking of CD7 or CD16 on NK cells induced adhesion to FN appeared to involve both protein tyrosine kinase and protein kinase C, because this adhesion was blocked in the presence of either genistein or a protein kinase C inhibitor, staurosporin.	Staurosporine	261-273	fibroblast growth factor receptor 4	Homo sapiens	112-135
7523501-8	1994	In addition, such PKC inhibitors as staurosporin or polymyxin B reduced NO production induced by IFN-gamma plus phorbol ester.	Staurosporine	36-48	interferon gamma	Mus musculus	97-106
7929127-10	1994	Staurosporine caused complete inhibition of ET-PAFR phosphorylation by PMA but only partial inhibition by PAF.	Staurosporine	0-13	platelet-activating factor receptor	Rattus norvegicus	47-51
7929127-10	1994	Staurosporine caused complete inhibition of ET-PAFR phosphorylation by PMA but only partial inhibition by PAF.	Staurosporine	0-13	PCNA clamp associated factor	Rattus norvegicus	47-50
7925997-2	1994	Thrombin-induced phosphorylation of JAK2 is inhibited by two structurally distinct inhibitors of tyrosine kinases, staurosporine and the tyrphostin ST271.	Staurosporine	115-128	coagulation factor II, thrombin	Homo sapiens	0-8
7925997-2	1994	Thrombin-induced phosphorylation of JAK2 is inhibited by two structurally distinct inhibitors of tyrosine kinases, staurosporine and the tyrphostin ST271.	Staurosporine	115-128	Janus kinase 2	Homo sapiens	36-40
7524364-6	1994	The enhanced beta-responsiveness produced by IL-1 was eliminated by adding amiloride to block Na+/H+ exchange or protein kinase C inhibitors staurosporine (10 nM) and calphostin C (50 nM).	Staurosporine	141-154	interleukin 1 beta	Homo sapiens	45-49
8087866-10	1994	The fact that PKC inhibitor staurosporine blocks PMA- but not CD16-induced downregulation suggests that CD16 downregulation can be achieved via two different pathways: one that is PKC dependent and one that is not.	Staurosporine	28-41	proline rich transmembrane protein 2	Homo sapiens	14-17
8087866-10	1994	The fact that PKC inhibitor staurosporine blocks PMA- but not CD16-induced downregulation suggests that CD16 downregulation can be achieved via two different pathways: one that is PKC dependent and one that is not.	Staurosporine	28-41	Fc gamma receptor IIIa	Homo sapiens	104-108
8087866-10	1994	The fact that PKC inhibitor staurosporine blocks PMA- but not CD16-induced downregulation suggests that CD16 downregulation can be achieved via two different pathways: one that is PKC dependent and one that is not.	Staurosporine	28-41	proline rich transmembrane protein 2	Homo sapiens	180-183
7882421-2	1994	Disruption of YDR1 resulted in hypersensitivity to cycloheximide, cerulenin, compactin, staurosporine and fluphenazine, indicating that YDR1 is an important determinant of cross resistance to apparently-unrelated drugs.	Staurosporine	88-101	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	14-18
7925583-8	1994	When neutrophils were pretreated with staurosporine, prior to desensitization, phosphorylation of pp39 was observed upon restimulation with IL-8.	Staurosporine	38-51	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
7925583-10	1994	Thus, homologous desensitization of neutrophils in response to IL-8 does not result from changes in receptor expression, but rather from a staurosporine-sensitive inactivation of subsequent signal transduction.	Staurosporine	139-152	C-X-C motif chemokine ligand 8	Homo sapiens	63-67
7630315-5	1995	Jatrophone, H-7 and staurosporine caused graded relaxations of preparations contracted with endothelin-1 or PMA with IC50s of 12 and &gt; 1000 microM, 8 and 13 microM and 7 and 12 nM, respectively.	Staurosporine	20-33	endothelin 1	Rattus norvegicus	92-104
7930675-6	1994	Auranofin and staurosporine, inhibitors of protein kinase C, inhibited phorbol-myristate-acetate-stimulated IL-8 production.	Staurosporine	14-27	C-X-C motif chemokine ligand 8	Homo sapiens	108-112
8089485-9	1994	The TNFR60-associated protein kinase activity is inhibited by staurosporine, but not by the protein kinase A and C inhibitors, HA-1004 and H7.	Staurosporine	62-75	TNF receptor superfamily member 1A	Homo sapiens	4-10
8089485-10	1994	Staurosporine greatly enhanced the sensitivity of U-937 cells to the cytotoxic effect of TNF.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	89-92
7523587-9	1994	The protein kinase inhibitors K252a and staurosporine block LIF-induced increases in tyrosine phosphorylation, activated Ras, and vasoactive intestinal polypeptide mRNA in NBFL cells.	Staurosporine	40-53	LIF interleukin 6 family cytokine	Homo sapiens	60-63
7861445-5	1994	In addition, TBI61 phosphorylation was inhibited by the PKC inhibitor, staurosporine, suggesting further that this protein may be a PKC substrate.	Staurosporine	71-84	protein kinase C, gamma	Rattus norvegicus	56-59
7861445-5	1994	In addition, TBI61 phosphorylation was inhibited by the PKC inhibitor, staurosporine, suggesting further that this protein may be a PKC substrate.	Staurosporine	71-84	protein kinase C, gamma	Rattus norvegicus	132-135
7525931-5	1994	Staurosporine and calphostin C, which are two PKC inhibitors, inhibited EGF-induced enzyme activity and mRNA expression of 12-lipoxygenase.	Staurosporine	0-13	protein kinase C alpha	Homo sapiens	46-49
7525931-5	1994	Staurosporine and calphostin C, which are two PKC inhibitors, inhibited EGF-induced enzyme activity and mRNA expression of 12-lipoxygenase.	Staurosporine	0-13	epidermal growth factor	Homo sapiens	72-75
7891841-4	1994	The effect of glutamate is mimicked by phorbol esters and is markedly reduced by inhibitors of protein kinase C (PKC) such as staurosporine and calphostin C. PP80 has been identified by Western blot analysis as the PKC substrate MARCKS (myristoylated alanine-rich C kinase substrate), while antibody to GAP-43 (growth associated protein-43), the nervous tissue-specific substrate of PKC, failed to recognize PP43.	Staurosporine	126-139	myristoylated alanine rich protein kinase C substrate	Homo sapiens	229-235
7891841-4	1994	The effect of glutamate is mimicked by phorbol esters and is markedly reduced by inhibitors of protein kinase C (PKC) such as staurosporine and calphostin C. PP80 has been identified by Western blot analysis as the PKC substrate MARCKS (myristoylated alanine-rich C kinase substrate), while antibody to GAP-43 (growth associated protein-43), the nervous tissue-specific substrate of PKC, failed to recognize PP43.	Staurosporine	126-139	myristoylated alanine rich protein kinase C substrate	Homo sapiens	237-282
7891841-4	1994	The effect of glutamate is mimicked by phorbol esters and is markedly reduced by inhibitors of protein kinase C (PKC) such as staurosporine and calphostin C. PP80 has been identified by Western blot analysis as the PKC substrate MARCKS (myristoylated alanine-rich C kinase substrate), while antibody to GAP-43 (growth associated protein-43), the nervous tissue-specific substrate of PKC, failed to recognize PP43.	Staurosporine	126-139	growth associated protein 43	Homo sapiens	303-309
7891841-4	1994	The effect of glutamate is mimicked by phorbol esters and is markedly reduced by inhibitors of protein kinase C (PKC) such as staurosporine and calphostin C. PP80 has been identified by Western blot analysis as the PKC substrate MARCKS (myristoylated alanine-rich C kinase substrate), while antibody to GAP-43 (growth associated protein-43), the nervous tissue-specific substrate of PKC, failed to recognize PP43.	Staurosporine	126-139	growth associated protein 43	Homo sapiens	311-339
7524081-8	1994	Ligand-induced tyrosine phosphorylation of IFN alpha R1 was blocked by the kinase inhibitors genistein or staurosporine.	Staurosporine	106-119	interferon alpha	Mus musculus	43-52
7925583-0	1994	Staurosporine restores signaling and inhibits interleukin-8-induced chemotactic desensitization.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	46-59
7943245-10	1994	Furthermore, in these PKC-alpha downregulated cells staurosporine no longer increased the secosteroid-stimulated transient rise in [Ca2+]i.	Staurosporine	52-65	protein kinase C alpha	Homo sapiens	22-31
7943237-7	1994	CCK-induced activation of MAP kinase may be mediated by protein kinase C, since 12-O-tetradecanoylphorbol 13-acetate (TPA) mimicked the effect of CCK and staurosporine concentration dependently inhibited the action of CCK.	Staurosporine	154-167	cholecystokinin	Rattus norvegicus	0-3
8092261-5	1994	Both desensitization to U-46619 and loss of TxA2 binding sites could be attenuated by the protein kinase C (PKC) inhibitors staurosporine, sphingosine, or H-7, and TxA2 receptor responsiveness was reduced in cells incubated with phorbol esters before stimulation with thromboxane agonists.	Staurosporine	124-137	protein kinase C, gamma	Rattus norvegicus	90-106
8092261-5	1994	Both desensitization to U-46619 and loss of TxA2 binding sites could be attenuated by the protein kinase C (PKC) inhibitors staurosporine, sphingosine, or H-7, and TxA2 receptor responsiveness was reduced in cells incubated with phorbol esters before stimulation with thromboxane agonists.	Staurosporine	124-137	protein kinase C, gamma	Rattus norvegicus	108-111
8093016-8	1994	(6) The phosphorylation of PLC gamma 2 was inhibited by staurosporine but not by Ro 31-8220.	Staurosporine	56-69	phospholipase C gamma 2	Homo sapiens	27-38
7704105-4	1994	Furthermore, a 24 h exposure to staurosporine greatly increased the levels of both proenkephalin A (proENK) and its messenger RNA (mRNA).	Staurosporine	32-45	proenkephalin	Bos taurus	83-98
7704105-4	1994	Furthermore, a 24 h exposure to staurosporine greatly increased the levels of both proenkephalin A (proENK) and its messenger RNA (mRNA).	Staurosporine	32-45	proenkephalin	Bos taurus	100-106
7704105-9	1994	However, the uncoupling of proENK mRNA induction from ME secretion in these cells is unique to staurosporine and, therefore, this compound may be useful for further studies on secretion-transcription coupling.	Staurosporine	95-108	proenkephalin	Bos taurus	27-33
7842388-4	1994	Inhibiting the activities of phospholipase C by neomycin and protein kinase C by staurosporine had no effect on basal release but decreased bombesin-stimulated gastrin release by up to 50%.	Staurosporine	81-94	gastrin releasing peptide	Homo sapiens	140-148
7842388-4	1994	Inhibiting the activities of phospholipase C by neomycin and protein kinase C by staurosporine had no effect on basal release but decreased bombesin-stimulated gastrin release by up to 50%.	Staurosporine	81-94	gastrin	Homo sapiens	160-167
7996789-6	1994	Staurosporine, a protein kinase C inhibitor, abolished the induction of HB-EGF mRNA by TPA and serum.	Staurosporine	0-13	heparin-binding EGF-like growth factor	Rattus norvegicus	72-78
8067998-5	1994	Furthermore, staurosporine treatment decreased the stability of R1 and CAT (chloramphenicol acetyltransferase)/R1 hybrid mRNAs, whereas PMA and okadaic acid increased the stability of these messages, in a dose-dependent manner.	Staurosporine	13-26	ribonucleotide reductase catalytic subunit M1	Homo sapiens	64-74
8049194-5	1994	Inhibition of HDL3-induced desensitization by 100 mumol/L H-7 or 10 mumol/L staurosporine is characterized by a marked reduction of the phosphorylation state of these proteins in permeabilized platelets.	Staurosporine	76-89	HDL3	Homo sapiens	14-18
8068015-0	1994	Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells.	Staurosporine	0-13	solute carrier family 2 member 1	Rattus norvegicus	96-101
8068015-0	1994	Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells.	Staurosporine	0-13	solute carrier family 2 member 4	Rattus norvegicus	106-111
8068015-7	1994	In intact adipose cells, staurosporine (30 microM) induced a slight (30%) decrease in the maximal insulin-induced receptor autophosphorylation and a similar decrease in the tyrosine phosphorylation of pp60 and pp160 (insulin-receptor substrate-1: "IRS-1"), but was without effect on insulin binding to its receptor.	Staurosporine	25-38	insulin receptor substrate 1	Rattus norvegicus	217-245
8068015-7	1994	In intact adipose cells, staurosporine (30 microM) induced a slight (30%) decrease in the maximal insulin-induced receptor autophosphorylation and a similar decrease in the tyrosine phosphorylation of pp60 and pp160 (insulin-receptor substrate-1: "IRS-1"), but was without effect on insulin binding to its receptor.	Staurosporine	25-38	insulin receptor substrate 1	Rattus norvegicus	248-253
8068015-8	1994	Conversely, staurosporine induced a concentration-dependent inhibition of the constitutively tyrosine-phosphorylated (pp120) protein and of an insulin-stimulated protein pp53 in the cytosol.	Staurosporine	12-25	CEA cell adhesion molecule 1	Rattus norvegicus	118-123
8068015-9	1994	The locus of staurosporine"s action appears to be distal from the initial insulin-receptor signalling, at a step that regulates the specific translocation of the glucose transporters to the plasma membranes.	Staurosporine	13-26	insulin receptor	Rattus norvegicus	74-90
7518388-5	1994	The protein kinase-C inhibitor staurosporine also attenuated agonist- and phorbol ester-induced PRG expression.	Staurosporine	31-44	proline rich protein BstNI subfamily 3	Homo sapiens	96-99
8000707-7	1994	TNF alpha-induced responses were completely inhibited by cytochalasin B and staurosporin, and partially blocked by pertussis toxin.	Staurosporine	76-88	tumor necrosis factor	Homo sapiens	0-9
7527777-4	1994	However, in PKC-down regulated cells, IGF-I and BAY K8644 could also evoke the DNA synthesis and the inhibitory effect of staurosporine persisted.	Staurosporine	122-135	insulin-like growth factor 1	Rattus norvegicus	38-43
8036020-4	1994	Interestingly, the effects of TPA are mimicked by the protein kinase inhibitor, staurosporine, which induces the expression of TPA target genes such as the neuronal differentiation-associated gene NPY in SH-SY5Y cells.	Staurosporine	80-93	neuropeptide Y	Homo sapiens	197-200
7815475-3	1994	It was found that NGF internalization was neither prevented by blocking p140trkA activity using the protein kinase inhibitors methylthioadenosine, staurosporine, and K-252a, nor by inhibiting NGF binding to p75NGFR with antibodies.	Staurosporine	147-160	nerve growth factor	Rattus norvegicus	18-21
7804606-4	1994	In contrast, two broadly active protein kinase inhibitors, staurosporine and K252a, inhibited the incorporation of 32P into NF-M by 60-70% and also blocked the post-translational mobility shift.	Staurosporine	59-72	CCAAT/enhancer binding protein beta	Gallus gallus	124-128
8036020-8	1994	Both staurosporine and TPA enhanced and modulated the binding of these DNA-protein complexes concomitant with the NPY mRNA expression.	Staurosporine	5-18	neuropeptide Y	Homo sapiens	114-117
8036020-11	1994	These protein complexes appear to contribute to the cell specific expression of the NPY gene and seem to be required during differentiation of SH-SY5Y human neuroblastoma cells further along the sympathetic neuronal lineage induced by either TPA or staurosporine.	Staurosporine	249-262	neuropeptide Y	Homo sapiens	84-87
8013347-8	1994	However, formation of the disulfide-linked hGHR was not blocked by attenuation of tyrosine kinase activation, in that pretreatment of cells with staurosporine (1.25 microM) prevented detectable hGH-induced tyrosine phosphorylation without preventing the appearance of p215-230.	Staurosporine	145-158	growth hormone receptor	Homo sapiens	43-47
7953671-2	1994	We now report that staurosporine and K-252 compounds, low molecular weight alkaloids of bacterial origin, can protect cultured rat hippocampal neurons against the toxicity of A beta in a concentration-dependent manner.	Staurosporine	19-32	amyloid beta precursor protein	Rattus norvegicus	175-181
7953671-4	1994	Measurements of [Ca2+]i using fura-2 imaging revealed that the elevation of [Ca2+]i that occurred in response to long-term exposure to A beta was attenuated in neurons treated with staurosporine and K-252 compounds.	Staurosporine	181-194	amyloid beta precursor protein	Rattus norvegicus	135-141
7517943-12	1994	The kinase was tentatively identified as protein kinase C, because it was inhibited by an analogue of staurosporine more specific for PKC and not by a PKA or tyrosine kinase inhibitors.	Staurosporine	102-115	protein kinase C epsilon	Homo sapiens	134-137
7527049-6	1994	Staurosporine (1 microM) inhibited K8/18 phosphorylation in okadaic acid- or nocodazole-treated cells, and inhibited the increase in K8/18 glycosylation without inhibiting the increase in terminal GlcNAc"s of membrane-associated glycoproteins.	Staurosporine	0-13	keratin 8	Homo sapiens	35-40
7527049-6	1994	Staurosporine (1 microM) inhibited K8/18 phosphorylation in okadaic acid- or nocodazole-treated cells, and inhibited the increase in K8/18 glycosylation without inhibiting the increase in terminal GlcNAc"s of membrane-associated glycoproteins.	Staurosporine	0-13	keratin 8	Homo sapiens	133-138
8021271-15	1994	These results, taken together, indicate that PGF2 alpha receptor-mediated tyrosine phosphorylation is evoked by a [Ca2+]i-dependent mechanism that is sensitive to staurosporine and H-7 but which is independent of PKC or Ca2+/calmodulin PKs.	Staurosporine	163-176	prostaglandin F receptor	Mus musculus	45-64
7932376-11	1994	Staurosporine, a protein kinase C inhibitor, inhibited the effect of melittin indicating that activation of phospholipase A2 by protein kinase C is an obligatory step in PG synthesis by bovine spermatozoa.	Staurosporine	0-13	LOC104974671	Bos taurus	108-124
8022202-0	1994	Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa B following tumour necrosis factor treatment of chronic B-leukaemia cells.	Staurosporine	19-32	nuclear factor kappa B subunit 1	Homo sapiens	84-94
8022202-0	1994	Redox reagents and staurosporine inhibit stimulation of the transcription regulator NF-kappa B following tumour necrosis factor treatment of chronic B-leukaemia cells.	Staurosporine	19-32	tumor necrosis factor	Homo sapiens	105-127
8022202-10	1994	However, the protein kinase inhibitor staurosporine inhibited TNF induction of NF-kappa B in four of five samples, suggesting that staurosporine-sensitive protein kinases (other than PKC) are involved in the signalling pathway.	Staurosporine	38-51	tumor necrosis factor	Homo sapiens	62-65
8022202-10	1994	However, the protein kinase inhibitor staurosporine inhibited TNF induction of NF-kappa B in four of five samples, suggesting that staurosporine-sensitive protein kinases (other than PKC) are involved in the signalling pathway.	Staurosporine	38-51	nuclear factor kappa B subunit 1	Homo sapiens	79-89
7525383-5	1994	rhIL-1 beta stimulated the secretion of PAI-1 in a dose-dependent fashion under basal culture conditions; the effect was reversed by actinomycin D and the protein kinase inhibitors H7 and staurosporine but not KT-5720.	Staurosporine	188-201	serpin family E member 1	Homo sapiens	40-45
8011674-3	1994	LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC.	Staurosporine	63-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	13-16
8011674-3	1994	LPS-mediated PLD activation of THP-1 or U-937 was inhibited by staurosporine (2 microM) and by protein kinase C (PKC) down-regulation with 12-O-tetradecanoylphorbol 13-acetate (TPA) suggesting a role for PKC.	Staurosporine	63-76	GLI family zinc finger 2	Homo sapiens	31-36
7972929-9	1994	However, 50 nM staurosporine inhibited only 65% of the gastrin and CCK induced increase in ODC activity suggesting that a portion of the G/CCKB receptor-mediated increase in ODC activity is PKC independent.	Staurosporine	15-28	gastrin	Rattus norvegicus	55-62
7972929-9	1994	However, 50 nM staurosporine inhibited only 65% of the gastrin and CCK induced increase in ODC activity suggesting that a portion of the G/CCKB receptor-mediated increase in ODC activity is PKC independent.	Staurosporine	15-28	cholecystokinin	Rattus norvegicus	67-70
7972929-9	1994	However, 50 nM staurosporine inhibited only 65% of the gastrin and CCK induced increase in ODC activity suggesting that a portion of the G/CCKB receptor-mediated increase in ODC activity is PKC independent.	Staurosporine	15-28	ornithine decarboxylase 1	Rattus norvegicus	91-94
7816053-3	1994	The insulin effect was blocked by the protein kinase inhibitor, staurosporine, indicating possible involvement of a protein kinase in insulin action.	Staurosporine	64-77	insulin	Homo sapiens	4-11
7816053-3	1994	The insulin effect was blocked by the protein kinase inhibitor, staurosporine, indicating possible involvement of a protein kinase in insulin action.	Staurosporine	64-77	insulin	Homo sapiens	134-141
8204888-9	1994	The PKC inhibitor staurosporine at low concentrations (100 ng/mL) caused a significant augmentation of MMP-9 release in untreated cultures that was blocked by the addition of anti-TNF-alpha.	Staurosporine	18-31	matrix metallopeptidase 9	Homo sapiens	103-108
8204888-9	1994	The PKC inhibitor staurosporine at low concentrations (100 ng/mL) caused a significant augmentation of MMP-9 release in untreated cultures that was blocked by the addition of anti-TNF-alpha.	Staurosporine	18-31	tumor necrosis factor	Homo sapiens	180-189
8205531-0	1994	Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points.	Staurosporine	0-13	proliferating cell nuclear antigen	Homo sapiens	61-67
8205531-0	1994	Staurosporine blocks cell progression through G1 between the cyclin D and cyclin E restriction points.	Staurosporine	0-13	proliferating cell nuclear antigen	Homo sapiens	74-80
8199204-5	1994	Both staurosporine and tyrphostin inhibited thrombin-stimulated tyrosine phosphorylation and PtdIns(3,4)P2 synthesis.	Staurosporine	5-18	coagulation factor II, thrombin	Homo sapiens	44-52
7520689-4	1994	Both staurosporine and herbimycin A reduced eosinophil survival in a time-dependent fashion at 10(-6) M and 10(-7) M. Ketotifen at 10(-4) M and theophylline at 10(-3) M, significantly decreased eosinophil viability (p &lt; 0.001 and p &lt; 0.001, respectively) in the presence of 100 pg/ml of recombinant human interleukin-5 (rhIL-5).	Staurosporine	5-18	interleukin 5	Homo sapiens	311-324
7514508-7	1994	Exposure to the protein kinase inhibitor staurosporine shifted the proportion of events toward the largest unitary conductance and resulted in decreased phosphorylation of human connexin43 in seryl residues in these cells.	Staurosporine	41-54	gap junction protein alpha 1	Homo sapiens	178-188
7924409-8	1994	These effects were inhibited by the broad spectrum protein kinase inhibitor staurosporine and the specific PKC antagonist calphostin C. Transforming growth factor-beta (TGF-beta)1 and TGF-beta 2, which are known to be present in eyes with PVR, were evaluated to determine their effect on gel contraction.	Staurosporine	76-89	transforming growth factor beta 1	Bos taurus	169-179
7924409-8	1994	These effects were inhibited by the broad spectrum protein kinase inhibitor staurosporine and the specific PKC antagonist calphostin C. Transforming growth factor-beta (TGF-beta)1 and TGF-beta 2, which are known to be present in eyes with PVR, were evaluated to determine their effect on gel contraction.	Staurosporine	76-89	transforming growth factor beta 2	Bos taurus	184-194
8079654-4	1994	Staurosporine, a potent protein kinase inhibitor, completely prevented the desensitization caused by PDB.	Staurosporine	0-13	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	24-38
8079654-8	1994	Staurosporine pretreatment resulted in only a slight restoration of the PTH response under conditions of homologous desensitization.	Staurosporine	0-13	parathyroid hormone	Rattus norvegicus	72-75
8200994-7	1994	Staurosporine (STP, 10(-8) M) prevented both 10(-9) and 10(-13) M ET-1 from altering Jv significantly indicating that protein kinase C (PKC) is involved.	Staurosporine	0-13	sulfotransferase family 1A member 1	Homo sapiens	15-18
8200994-7	1994	Staurosporine (STP, 10(-8) M) prevented both 10(-9) and 10(-13) M ET-1 from altering Jv significantly indicating that protein kinase C (PKC) is involved.	Staurosporine	0-13	endothelin 1	Homo sapiens	66-70
7516398-11	1994	RANTES-induced production of reactive oxygen species was almost completely inhibited by staurosporine, wortmannin, or pertussis toxin.	Staurosporine	88-101	C-C motif chemokine ligand 5	Homo sapiens	0-6
8189216-3	1994	A maximal stimulation of 4.5-fold in the AT1 receptor mRNA transcript level is observed with 200 nM PMA in 4 h and is blocked by 1 microM staurosporine.	Staurosporine	138-151	angiotensin II receptor, type 1a	Rattus norvegicus	41-44
8022414-10	1994	An analysis of the inhibition by UCN-01 and staurosporine of the kinase activity of PKC-alpha and -delta indicated mixed inhibition kinetics.	Staurosporine	44-57	protein kinase C alpha	Homo sapiens	84-93
7735968-0	1994	Staurosporine encapsulated into pH-sensitive liposomes reduces tnf production and increases survival in rat endotoxin shock.	Staurosporine	0-13	tumor necrosis factor	Rattus norvegicus	63-66
7735968-3	1994	In this study, we examined whether pH-sensitive liposomes containing staurosporine (STP), a potent inhibitor of PKC, when injected intravenously would suppress TNF production and reduce mortality in an endotoxin rat model.	Staurosporine	69-82	tumor necrosis factor-like	Rattus norvegicus	160-163
7735968-3	1994	In this study, we examined whether pH-sensitive liposomes containing staurosporine (STP), a potent inhibitor of PKC, when injected intravenously would suppress TNF production and reduce mortality in an endotoxin rat model.	Staurosporine	84-87	tumor necrosis factor-like	Rattus norvegicus	160-163
8186258-3	1994	We studied the effect of two PKC inhibitors, staurosporine (STP) and sphingosine (SPG), on TNF production in rat alveolar macrophages (AM) and in whole blood (BM) incubated with 0.25-25,000 ng/ml of LPS.	Staurosporine	45-58	tumor necrosis factor-like	Rattus norvegicus	91-94
8186258-3	1994	We studied the effect of two PKC inhibitors, staurosporine (STP) and sphingosine (SPG), on TNF production in rat alveolar macrophages (AM) and in whole blood (BM) incubated with 0.25-25,000 ng/ml of LPS.	Staurosporine	60-63	tumor necrosis factor-like	Rattus norvegicus	91-94
8194597-3	1994	Glioma cell lines were treated with PKC inhibitors staurosporine (10 nM), and tamoxifen (10 microM).	Staurosporine	51-64	proline rich transmembrane protein 2	Homo sapiens	36-39
8204096-2	1994	Staurosporine, a potent PKC inhibitor, interferes with PKC catalytic activity without altering phorbol ester binding sites in cell-free systems.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	24-27
8204096-2	1994	Staurosporine, a potent PKC inhibitor, interferes with PKC catalytic activity without altering phorbol ester binding sites in cell-free systems.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	55-58
8176220-6	1994	A role for protein kinase C in the regulation of astrocyte LIF production was suggested by the findings that phorbol esters induced both LIF mRNA and protein and that the cytokine-induced LIF increase was partially antagonized by relatively selective inhibitors of protein kinase C such as H7 and staurosporine.	Staurosporine	297-310	LIF interleukin 6 family cytokine	Homo sapiens	59-62
7958271-0	1994	Inhibition of insulin release by staurosporine and Ro 31-8220: a role for protein kinase C?	Staurosporine	33-46	insulin	Homo sapiens	14-21
7514113-6	1994	Furthermore, both the PMA-induced pathway of irreversible aggregation, blocked by staurosporine, as well as the FMLP-induced pathway of reversible aggregation, augmented by staurosporine, were inhibited by okadaic acid in a dose- and time-dependent manner.	Staurosporine	173-186	formyl peptide receptor 1	Homo sapiens	112-116
7512497-6	1994	Staurosporine, a protein kinase-C inhibitor, increased H19 and IGF-II RNA to the same extent as did ACTH.	Staurosporine	0-13	H19 imprinted maternally expressed transcript	Homo sapiens	55-58
7512497-6	1994	Staurosporine, a protein kinase-C inhibitor, increased H19 and IGF-II RNA to the same extent as did ACTH.	Staurosporine	0-13	insulin like growth factor 2	Homo sapiens	63-69
7512498-15	1994	Since suramin and staurosporine increased media levels of the IGFBP, this suggests that constitutive secretion of TGF-beta 1, bFGF, or EGF might provide a tonic suppressive mechanism for controlling IGFBP secretion.	Staurosporine	18-31	transforming growth factor, beta 1	Mus musculus	114-124
7512498-15	1994	Since suramin and staurosporine increased media levels of the IGFBP, this suggests that constitutive secretion of TGF-beta 1, bFGF, or EGF might provide a tonic suppressive mechanism for controlling IGFBP secretion.	Staurosporine	18-31	fibroblast growth factor 2	Mus musculus	126-130
8174632-12	1994	The induction of c-fos by PMA was sensitive to staurosporine or GF 109203X.	Staurosporine	47-60	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
8188084-3	1994	Staurosporine, a protein kinase C inhibitor, partially blocked the EGF effects on [3H]thymidine incorporation.	Staurosporine	0-13	epidermal growth factor	Homo sapiens	67-70
7512976-0	1994	Staurosporine, a non-specific PKC inhibitor, induces keratinocyte differentiation and raises intracellular calcium, but Ro31-8220, a specific inhibitor, does not.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	30-33
7512976-3	1994	Surprisingly the response to nanomolar concentrations of staurosporine was similar to TPA and induced a fusiform morphology, inhibited growth, increased involucrin levels, and raised intracellular calcium.	Staurosporine	57-70	plasminogen activator, tissue type	Homo sapiens	86-89
7512976-7	1994	These results suggest PKC activation is required for keratinocyte differentiation and that staurosporine acts like a PKC agonist to give a similar effect as TPA.	Staurosporine	91-104	proline rich transmembrane protein 2	Homo sapiens	117-120
7513708-0	1994	Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation.	Staurosporine	0-13	agrin	Gallus gallus	23-28
7513708-0	1994	Staurosporine inhibits agrin-induced acetylcholine receptor phosphorylation and aggregation.	Staurosporine	0-13	cholinergic receptor nicotinic delta subunit	Gallus gallus	37-59
7513708-3	1994	Staurosporine, an antagonist of both protein serine and tyrosine kinases, blocked agrin-induced AChR aggregation in a dose-dependent manner; 50% inhibition occurred at approximately 2 nM.	Staurosporine	0-13	agrin	Gallus gallus	82-87
7513708-3	1994	Staurosporine, an antagonist of both protein serine and tyrosine kinases, blocked agrin-induced AChR aggregation in a dose-dependent manner; 50% inhibition occurred at approximately 2 nM.	Staurosporine	0-13	cholinergic receptor nicotinic delta subunit	Gallus gallus	96-100
7513708-5	1994	Staurosporine blocked agrin-induced phosphorylation of the AChR beta subunit, which occurs at least in part on tyrosine residues, but did not reduce phosphorylation of the gamma and delta subunits, which occurs on serine/threonine residues.	Staurosporine	0-13	agrin	Gallus gallus	22-27
7513708-5	1994	Staurosporine blocked agrin-induced phosphorylation of the AChR beta subunit, which occurs at least in part on tyrosine residues, but did not reduce phosphorylation of the gamma and delta subunits, which occurs on serine/threonine residues.	Staurosporine	0-13	cholinergic receptor nicotinic delta subunit	Gallus gallus	59-63
7513708-6	1994	Staurosporine also prevented the agrin-induced decrease in the rate at which AChRs are extracted from intact myotubes by mild detergents.	Staurosporine	0-13	agrin	Gallus gallus	33-38
8163561-7	1994	In particular, protein kinase C would mediate the effects of high hormone concentrations, acting as a growth factor, since staurosporine fully inhibited insulin 1 microM, but only partially 1 nM effects, and tyrosine kinase would mediate the effect of insulin 1 nM and only partially 1 microM.	Staurosporine	123-136	insulin 1	Rattus norvegicus	153-162
8046298-3	1994	Protein kinase C (PKC) inhibitors H-7 and staurosporine blocked this inhibitory effect of ACTH, whereas 12-0-tetradecanoyl phorbol-13-acetate (TPA; a PKC activator) mimicked the ACTH-induced antimitogenic effect.	Staurosporine	42-55	protein kinase C, gamma	Rattus norvegicus	0-16
8046298-3	1994	Protein kinase C (PKC) inhibitors H-7 and staurosporine blocked this inhibitory effect of ACTH, whereas 12-0-tetradecanoyl phorbol-13-acetate (TPA; a PKC activator) mimicked the ACTH-induced antimitogenic effect.	Staurosporine	42-55	protein kinase C, gamma	Rattus norvegicus	18-21
7519679-7	1994	Phosphorylation of CFTR was shown by the facts that CFTR-GCl could be activated by cAMP and inhibited by the kinase antagonist staurosporine, or by removal of either substrate ATP or Mg2+ cofactor.	Staurosporine	127-140	CF transmembrane conductance regulator	Homo sapiens	19-23
7519679-7	1994	Phosphorylation of CFTR was shown by the facts that CFTR-GCl could be activated by cAMP and inhibited by the kinase antagonist staurosporine, or by removal of either substrate ATP or Mg2+ cofactor.	Staurosporine	127-140	CF transmembrane conductance regulator	Homo sapiens	52-56
7519679-7	1994	Phosphorylation of CFTR was shown by the facts that CFTR-GCl could be activated by cAMP and inhibited by the kinase antagonist staurosporine, or by removal of either substrate ATP or Mg2+ cofactor.	Staurosporine	127-140	germ cell-less 2, spermatogenesis associated	Homo sapiens	57-60
8182533-5	1994	In addition, myoinositol, a precursor of the PKC-activating pathway, induced a 2-fold increase in PAH accumulation at a concentration of 10(-5) M. These effects were abolished by the administration of staurosporine at low concentrations (10(-9) and 10(-8) M).	Staurosporine	201-214	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	98-101
8182533-6	1994	Staurosporine on its own diminished the PAH uptake in a concentration-dependent manner at bath concentrations ranging from 10(-7) to 10(-5) M. We conclude that the PKC system may be an important modulator of the basolateral PAH transport in renal S2 proximal tubules.	Staurosporine	0-13	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	40-43
8182533-6	1994	Staurosporine on its own diminished the PAH uptake in a concentration-dependent manner at bath concentrations ranging from 10(-7) to 10(-5) M. We conclude that the PKC system may be an important modulator of the basolateral PAH transport in renal S2 proximal tubules.	Staurosporine	0-13	phenylalanine-4-hydroxylase	Oryctolagus cuniculus	224-227
8190095-7	1994	Measurement of LTC4 synthase enzymatic activity in cells challenged with A23187 and PMA in the presence or absence of staurosporine demonstrated that the activity of the LTC4 synthase enzyme was inhibited in cells costimulated with A23187 and PMA and that inhibition could also be completely prevented by the presence of staurosporine.	Staurosporine	118-131	leukotriene C4 synthase	Homo sapiens	170-183
8190095-7	1994	Measurement of LTC4 synthase enzymatic activity in cells challenged with A23187 and PMA in the presence or absence of staurosporine demonstrated that the activity of the LTC4 synthase enzyme was inhibited in cells costimulated with A23187 and PMA and that inhibition could also be completely prevented by the presence of staurosporine.	Staurosporine	321-334	leukotriene C4 synthase	Homo sapiens	170-183
8190095-8	1994	Because PMA is known to activate PKC, and staurosporine and bisindolylmaleimide are inhibitors of PKC, these results suggest that LTC4 synthase in HL-60 cells may be phosphoregulated.	Staurosporine	42-55	proline rich transmembrane protein 2	Homo sapiens	98-101
8190095-8	1994	Because PMA is known to activate PKC, and staurosporine and bisindolylmaleimide are inhibitors of PKC, these results suggest that LTC4 synthase in HL-60 cells may be phosphoregulated.	Staurosporine	42-55	leukotriene C4 synthase	Homo sapiens	130-143
8190100-8	1994	In addition, 5-HT-mediated amplification of cAMP accumulation was reduced by the PKC inhibitor staurosporine in normal cells but was unaffected in PKC-depleted cells.	Staurosporine	95-108	protein kinase C epsilon	Homo sapiens	81-84
9397948-5	1994	The PKC inhibitors (H-7, staurosporin, and sphingosine) all blocked PMA-mediated up-regulation of VDR in a dose-dependent manner.	Staurosporine	25-37	vitamin D receptor	Rattus norvegicus	98-101
8058478-5	1994	The effects of both the phorbol ester and cholera toxin were inhibited by staurosporine, thus indicating that either direct or indirect (via G protein) activation of PKC accounts for the decrease of GCl.	Staurosporine	74-87	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	199-202
8163013-3	1994	Staurosporine alone induced a weak, transient rise in cytosolic free calcium levels ([Ca2+]i) from release of internal Ca2+ stores but potentiated the effect induced by thrombin.	Staurosporine	0-13	coagulation factor II, thrombin	Homo sapiens	169-177
7519562-0	1994	Basal and acidic fibroblast growth factor-induced atrial natriuretic peptide gene expression and secretion is inhibited by staurosporine.	Staurosporine	123-136	fibroblast growth factor 1	Rattus norvegicus	10-41
7519562-0	1994	Basal and acidic fibroblast growth factor-induced atrial natriuretic peptide gene expression and secretion is inhibited by staurosporine.	Staurosporine	123-136	natriuretic peptide A	Rattus norvegicus	50-76
7519562-1	1994	We examined the mechanisms involved in the activation of atrial natriuretic peptide (ANP) gene expression and secretion in response to acidic fibroblast growth factor (aFGF) by studying the effects of staurosporine, a protein kinase C inhibitor, and 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C, on basal and AFGF-induced ANP messenger RNA (mRNA) and immunoreactive ANP (IR-ANP) levels in cultured neonatal rat cardiac myocytes.	Staurosporine	201-214	natriuretic peptide A	Rattus norvegicus	57-83
7519562-5	1994	Staurosporine alone at concentration of 10 nM significantly decreased the basal IR-ANP and IR-NT-proANP secretion, and inhibited the aFGF-induced increase in ANP mRNA and IR-ANP levels in ventricular myocytes.	Staurosporine	0-13	natriuretic peptide A	Rattus norvegicus	83-86
7519562-5	1994	Staurosporine alone at concentration of 10 nM significantly decreased the basal IR-ANP and IR-NT-proANP secretion, and inhibited the aFGF-induced increase in ANP mRNA and IR-ANP levels in ventricular myocytes.	Staurosporine	0-13	fibroblast growth factor 1	Rattus norvegicus	133-137
7519562-5	1994	Staurosporine alone at concentration of 10 nM significantly decreased the basal IR-ANP and IR-NT-proANP secretion, and inhibited the aFGF-induced increase in ANP mRNA and IR-ANP levels in ventricular myocytes.	Staurosporine	0-13	natriuretic peptide A	Rattus norvegicus	100-103
7519562-5	1994	Staurosporine alone at concentration of 10 nM significantly decreased the basal IR-ANP and IR-NT-proANP secretion, and inhibited the aFGF-induced increase in ANP mRNA and IR-ANP levels in ventricular myocytes.	Staurosporine	0-13	natriuretic peptide A	Rattus norvegicus	100-103
7519562-9	1994	The observations that (a) staurosporine completely abolished the effects of aFGF on ANP gene expression and release and (b) ANP secretory and gene expression inducing effects of phorbol ester were not augmented by aFGF, suggest an important role of protein kinase C in mediating aFGF-induced ANP gene expression and secretion.	Staurosporine	26-39	fibroblast growth factor 1	Rattus norvegicus	76-80
7519562-9	1994	The observations that (a) staurosporine completely abolished the effects of aFGF on ANP gene expression and release and (b) ANP secretory and gene expression inducing effects of phorbol ester were not augmented by aFGF, suggest an important role of protein kinase C in mediating aFGF-induced ANP gene expression and secretion.	Staurosporine	26-39	natriuretic peptide A	Rattus norvegicus	84-87
8144608-0	1994	Staurosporine induces the cell surface expression of both forms of human tumor necrosis factor receptors on myeloid and epithelial cells and modulates ligand-induced cellular response.	Staurosporine	0-13	tumor necrosis factor	Homo sapiens	73-94
8144608-2	1994	In this report, we examined the effect of staurosporine on the constitutive expression of tumor necrosis factor (TNF) receptors in K562, a human erythroblastoid leukemic cell line.	Staurosporine	42-55	tumor necrosis factor	Homo sapiens	90-111
8144608-2	1994	In this report, we examined the effect of staurosporine on the constitutive expression of tumor necrosis factor (TNF) receptors in K562, a human erythroblastoid leukemic cell line.	Staurosporine	42-55	tumor necrosis factor	Homo sapiens	113-116
8144608-3	1994	Exposure of these cells to staurosporine enhanced cell surface expression of TNF receptors by almost 7-fold in a dose- and time-dependent fashion.	Staurosporine	27-40	tumor necrosis factor	Homo sapiens	77-80
8144608-7	1994	TNF receptors were induced by staurosporine on a wide variety of human cells of both epithelial (primarily p60 receptors) and myeloid (mainly p80 receptor) origin.	Staurosporine	30-43	tumor necrosis factor	Homo sapiens	0-3
8144608-7	1994	TNF receptors were induced by staurosporine on a wide variety of human cells of both epithelial (primarily p60 receptors) and myeloid (mainly p80 receptor) origin.	Staurosporine	30-43	sequestosome 1	Homo sapiens	107-110
8144608-10	1994	Furthermore, we found that staurosporine had no effect on the internalization or shedding of the receptor, but it induced the mRNA for both forms of the TNF receptor.	Staurosporine	27-40	tumor necrosis factor	Homo sapiens	153-156
8144608-12	1994	Modulation of the receptor number by staurosporine correlated with the enhancement of antiproliferative effects of TNF against different tumor cells.	Staurosporine	37-50	tumor necrosis factor	Homo sapiens	115-118
8061618-4	1994	Increased transcription of CYP1A1 gene by TCDD was also suppressed by staurosporine treatment.	Staurosporine	70-83	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	27-33
8075399-2	1994	20 within 4 h. Induction of cim 1 mRNA accumulation occurred at benzyladenine concentrations as low as 10(-8) M. Furthermore, cim 1 mRNA accumulation was stimulated in the absence of cytokinin by staurosporine (an inhibitor of protein kinases) and inhibited in the presence of cytokinin by okadaic acid (an inhibitor of protein phosphatases 1 and 2a), suggesting that cim 1 accumulation in response to cytokinin is dependent on cytokinin-induced dephosphorylation of one or more cellular proteins.	Staurosporine	196-209	cytokinin induced message	Glycine max	28-33
8075399-2	1994	20 within 4 h. Induction of cim 1 mRNA accumulation occurred at benzyladenine concentrations as low as 10(-8) M. Furthermore, cim 1 mRNA accumulation was stimulated in the absence of cytokinin by staurosporine (an inhibitor of protein kinases) and inhibited in the presence of cytokinin by okadaic acid (an inhibitor of protein phosphatases 1 and 2a), suggesting that cim 1 accumulation in response to cytokinin is dependent on cytokinin-induced dephosphorylation of one or more cellular proteins.	Staurosporine	196-209	cytokinin induced message	Glycine max	126-131
8075399-2	1994	20 within 4 h. Induction of cim 1 mRNA accumulation occurred at benzyladenine concentrations as low as 10(-8) M. Furthermore, cim 1 mRNA accumulation was stimulated in the absence of cytokinin by staurosporine (an inhibitor of protein kinases) and inhibited in the presence of cytokinin by okadaic acid (an inhibitor of protein phosphatases 1 and 2a), suggesting that cim 1 accumulation in response to cytokinin is dependent on cytokinin-induced dephosphorylation of one or more cellular proteins.	Staurosporine	196-209	cytokinin induced message	Glycine max	126-131
8037750-0	1994	Effect of staurosporine on the transcription of HSP70 heat shock gene in HT-29 cells.	Staurosporine	10-23	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-53
8037750-1	1994	We have investigated the effects of staurosporine (STP), an inhibitor of PKC, on the expression of the HSP70 gene in human colon carcinoma HT-29 cells.	Staurosporine	36-49	heat shock protein family A (Hsp70) member 4	Homo sapiens	103-108
8037750-1	1994	We have investigated the effects of staurosporine (STP), an inhibitor of PKC, on the expression of the HSP70 gene in human colon carcinoma HT-29 cells.	Staurosporine	51-54	heat shock protein family A (Hsp70) member 4	Homo sapiens	103-108
8027047-5	1994	The combined effect of stretch and AII on PTHrP mRNA expression is strongly attenuated by the protein kinase C (PKC) inhibitor staurosporine or by down-regulation of PKC, suggesting that PKC plays an important role in the synergistic response.	Staurosporine	127-140	angiotensinogen	Rattus norvegicus	35-38
8027047-5	1994	The combined effect of stretch and AII on PTHrP mRNA expression is strongly attenuated by the protein kinase C (PKC) inhibitor staurosporine or by down-regulation of PKC, suggesting that PKC plays an important role in the synergistic response.	Staurosporine	127-140	parathyroid hormone-like hormone	Rattus norvegicus	42-47
7947388-9	1994	TPA-induced expression of NGFI-A and c-fos and death of LNCaP cultures were blocked by pretreatment with staurosporine, a potent inhibitor of several protein kinases.	Staurosporine	105-118	early growth response 1	Homo sapiens	26-32
7947388-9	1994	TPA-induced expression of NGFI-A and c-fos and death of LNCaP cultures were blocked by pretreatment with staurosporine, a potent inhibitor of several protein kinases.	Staurosporine	105-118	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
7517402-9	1994	The CSC induced expression of CD11b in monocytes was optimal at 25-30 min and was inhibited by protein kinase C inhibitors, staurosporine and H-7, and also by baicalein, a lipoxygenase inhibitor.	Staurosporine	124-137	integrin subunit alpha M	Homo sapiens	30-35
8137494-8	1994	Coincubation with staurosporine or calphostin C, inhibitors of PKC, during treatment of the arteries with Ox-LDL or lysoPC attenuated the augmentative effects of Ox-LDL and lysoPC on endothelial ICAM-1 expression, endothelial adhesiveness to PMNs, and PMN-induced EDR impairment.	Staurosporine	18-31	intercellular adhesion molecule 1	Homo sapiens	195-201
8005230-9	1994	Another known PKC inhibitor staurosporine (STSP) did not inhibit but rather enhanced the effect of Epo.	Staurosporine	28-41	erythropoietin	Mus musculus	99-102
8005230-9	1994	Another known PKC inhibitor staurosporine (STSP) did not inhibit but rather enhanced the effect of Epo.	Staurosporine	43-47	erythropoietin	Mus musculus	99-102
8144543-2	1994	The protein kinase inhibitor staurosporine has been used to examine the role of H1 and H3 phosphorylations in controlling chromosome condensation in the mouse FM3A cell line.	Staurosporine	29-42	histocompatibility 1	Mus musculus	80-89
8014197-7	1994	Contrary to 3T3 fibroblasts, where ras-p21 is functionally dependent for its mitogenic activity on TPA- and staurosporine-sensitive PKC isoforms, in Xenopus oocytes, induction of GVBD by ras-p21 was independent of PKC, while PLC-induced GVBD was sensitive to PKC inhibition.	Staurosporine	108-121	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	39-42
8144543-3	1994	We present evidence that (i) staurosporine inhibits the protein kinases that phosphorylate histone H1 during mitosis, (ii) staurosporine also inhibits the histone H3-specific kinase, (iii) the inhibition of these kinase activities prevent cells from entering mitosis, and (iv) addition of staurosporine to cells already arrested at metaphase by nocodazole causes a rapid dephosphorylation of histones H1 and H3 and the decondensation of the metaphase chromosomes.	Staurosporine	29-42	histocompatibility 1	Mus musculus	401-410
8144543-3	1994	We present evidence that (i) staurosporine inhibits the protein kinases that phosphorylate histone H1 during mitosis, (ii) staurosporine also inhibits the histone H3-specific kinase, (iii) the inhibition of these kinase activities prevent cells from entering mitosis, and (iv) addition of staurosporine to cells already arrested at metaphase by nocodazole causes a rapid dephosphorylation of histones H1 and H3 and the decondensation of the metaphase chromosomes.	Staurosporine	123-136	histocompatibility 1	Mus musculus	401-410
8144543-3	1994	We present evidence that (i) staurosporine inhibits the protein kinases that phosphorylate histone H1 during mitosis, (ii) staurosporine also inhibits the histone H3-specific kinase, (iii) the inhibition of these kinase activities prevent cells from entering mitosis, and (iv) addition of staurosporine to cells already arrested at metaphase by nocodazole causes a rapid dephosphorylation of histones H1 and H3 and the decondensation of the metaphase chromosomes.	Staurosporine	123-136	histocompatibility 1	Mus musculus	401-410
8158251-14	1994	Intracellular dialysis with the general kinase inhibitors H-7 (100 microM), staurosporine (400 nM), and a 20 amino acid protein kinase inhibitor (1 microM) also significantly prevented the THCC and PES inhibition of the Ca2+ channel current.	Staurosporine	76-89	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	220-223
8133266-7	1994	The responsiveness to CCK-8 was also reduced by phorbol 12,13-dibutyrate (PDBu), and this effect of PDBu was completely abolished by preincubation with staurosporine.	Staurosporine	152-165	cholecystokinin	Rattus norvegicus	22-25
8133266-8	1994	Staurosporine significantly attenuated the desensitization caused by preincubation with CCK-8, but this effect was too small to attribute the desensitization to the protein kinase C transduction pathway alone.	Staurosporine	0-13	cholecystokinin	Rattus norvegicus	88-91
8146329-2	1994	This increase in GRP78 protein and mRNA induced by hypoxia can be abolished by a 1-h pretreatment of cells before hypoxia with the protein kinase C (PKC) inhibitors staurosporine and H7 at concentrations at which the drugs themselves do not cause cytotoxicity.	Staurosporine	165-178	heat shock protein family A (Hsp70) member 5	Homo sapiens	17-22
12232162-6	1994	However, staurosporin inhibited arachidonate"s suppression of hmg1 gene expression.	Staurosporine	9-21	3-hydroxy-3-methylglutaryl-coenzyme A reductase 1	Solanum tuberosum	62-66
8146329-3	1994	Although all studies using protein kinase inhibitors must be interpreted with caution, staurosporine and H7 have been shown to be potent inhibitors of PKC activity, suggesting a role for PKC in mediating the transcriptional regulation of GRP78 by hypoxia.	Staurosporine	87-100	heat shock protein family A (Hsp70) member 5	Homo sapiens	238-243
8032322-0	1994	Staurosporine and gossypol are inhibitors of the function of peptide elongation factor 1 alpha from rabbit reticulocytes.	Staurosporine	0-13	elongation factor 1-alpha 1	Oryctolagus cuniculus	69-94
8146150-8	1994	Staurosporin and genistein inhibited GM-CSF-induced tyrosine phosphorylation of MAP kinase in human neutrophils and HL-60 cells without affecting GM-CSF-stimulated uptake of 2-deoxyglucose.	Staurosporine	0-12	colony stimulating factor 2	Homo sapiens	37-43
8125929-5	1994	Staurosporine and calphostin C, two potent inhibitors of the serine/threonine protein kinase, protein kinase C, significantly attenuated the angiotensin II-induced eIF-4E phosphorylation.	Staurosporine	0-13	angiotensinogen	Homo sapiens	141-155
8125929-5	1994	Staurosporine and calphostin C, two potent inhibitors of the serine/threonine protein kinase, protein kinase C, significantly attenuated the angiotensin II-induced eIF-4E phosphorylation.	Staurosporine	0-13	eukaryotic translation initiation factor 4E	Homo sapiens	164-170
8125929-6	1994	Staurosporine and calphostin C also blunted the angiotensin II-stimulated protein synthesis.	Staurosporine	0-13	angiotensinogen	Homo sapiens	48-62
8142369-6	1994	The rapid stimulatory effect of GnRH on gonadotropin subunit mRNA levels was abolished by the PKC inhibitors, staurosporine and GF 109203X.	Staurosporine	110-123	gonadotropin releasing hormone 1	Rattus norvegicus	32-36
7510523-3	1994	The protein kinase A (PKA)-specific inhibitor, KT5720, also inhibited the IL-1-induced PGE2 production in MC3T3-E1 cells, as did staurosporine, a potent inhibitor of protein kinase C (PKC).	Staurosporine	129-142	interleukin 1 complex	Mus musculus	74-78
8160842-5	1994	Inhibition of protein kinase (PK) C using staurosporine (10 nM) reduced basal ET-1 release by approximately 50% and completely prevented the response to FCS.	Staurosporine	42-55	endothelin 1	Homo sapiens	78-82
8135755-3	1994	A role for PKC in Ang II-induced 6-oxo-PGF1 alpha formation and ANP secretion was apparent, insofar as both responses were suppressed in the presence of the PKC inhibitors staurosporine (1 microM) and CGP 41251 (1 microM), as well as in cells in which PKC had been previously down-regulated by pretreatment with phorbol diester.	Staurosporine	172-185	angiotensinogen	Rattus norvegicus	18-24
8118827-8	1994	Staurosporine and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine inhibited PDT mediated c-fos activation while N-(2-guanidinoethyl)-5-isoquinoline-sulfonamide had no effect.	Staurosporine	0-13	FBJ osteosarcoma oncogene	Mus musculus	87-92
7510248-3	1994	Staurosporin inhibited the induction of c-fos by hypergravity almost completely at a concentration of 0.1 microM, but it inhibited the induction of egr-1 only partially.	Staurosporine	0-12	FBJ osteosarcoma oncogene	Mus musculus	40-45
7510248-3	1994	Staurosporin inhibited the induction of c-fos by hypergravity almost completely at a concentration of 0.1 microM, but it inhibited the induction of egr-1 only partially.	Staurosporine	0-12	early growth response 1	Mus musculus	148-153
7906314-6	1994	The inhibitory effect of PMA was blocked by staurosporine in a dose-dependent fashion, suggesting that it is mediated by protein kinase C. PMA treatment of A2.01.CD4.401 cells reduced the number of infected cells 6.7-fold, as estimated by a quantitative analysis of the HIV-1 MN infection kinetics, probably by affecting the stage of virus entry into cells.	Staurosporine	44-57	CD4 molecule	Homo sapiens	162-165
8125132-15	1994	A non-selective protein kinase inhibitor, staurosporine, inhibited both PBu2 and C5a-stimulated adhesion.	Staurosporine	42-55	complement C5a receptor 1	Homo sapiens	81-84
8129736-7	1994	Of the other activators of PLD tested, phenanthroline also enhanced the stimulatory effects of platelet-derived growth factor and staurosporine, but not that of sphingosine and H2O2, on the hydrolysis of both phospholipids.	Staurosporine	130-143	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	27-30
8305497-1	1994	Protein kinase C (PKC) inhibitors, staurosporine or 1,5-isoquinolinesulfonyl)-2-methylpiperazine (H7), inhibited NADPH oxidase activity and phosphorylation of 47 kDa protein (p47) in PMA-stimulated neutrophils in a dose-dependent manner.	Staurosporine	35-48	pleckstrin	Homo sapiens	175-178
8305497-4	1994	In the presence of ionomycin, which increased intracellular calcium ion concentrations, staurosporine was less effective in inhibiting both superoxide generation and p47 phosphorylation stimulated by PMA, similar to its effect in OZ-stimulated cells.	Staurosporine	88-101	pleckstrin	Homo sapiens	166-169
8129736-0	1994	The zinc chelator 1,10-phenanthroline enhances the stimulatory effects of protein kinase C activators and staurosporine, but not sphingosine and H2O2, on phospholipase D activity in NIH 3T3 fibroblasts.	Staurosporine	106-119	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	154-169
8129736-8	1994	These results suggest that regulation of PLD by PKC activators and staurosporine involves a common intermediate step, which is inhibited by a chelatable cellular pool of zinc.	Staurosporine	67-80	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	41-44
7507837-7	1994	Inhibitors of protein kinase-C (PKC), such as staurosporine and H7, also blocked the effect of dopamine.	Staurosporine	46-59	protein kinase C, epsilon	Rattus norvegicus	32-35
8113023-6	1994	The mechanism of thrombin-induced RPE cell gap formation was studied by preincubation with specific drugs, including a protein kinase inhibitor (staurosporine), protein kinase C inhibitors (H-7 and calphostin C), cyclic adenosine monophosphate (cAMP) inducer (forskolin), and cytoskeleton-disrupting agents (cytochalasin B or colchicine).	Staurosporine	145-158	coagulation factor II, thrombin	Bos taurus	17-25
8301134-7	1994	In contrast, the addition of staurosporine to macrophages as late as 2 h after treatment with high doses of rIFN-gamma inhibited the induction of I-A persistence.	Staurosporine	29-42	interferon gamma	Rattus norvegicus	108-118
8121307-6	1994	The presence of staurosporine, an inhibitor of the protein kinase C signaling pathway, completely prevented the inhibitory effect of ET-1 on adipose differentiation.	Staurosporine	16-29	endothelin 1	Homo sapiens	133-137
8109973-6	1994	PMA-induced PAF receptor downregulation was staurosporine-sensitive while PAF receptor downregulation by A23187, FMLP, or LTB4 was staurosporine-resistant.	Staurosporine	44-57	PCNA clamp associated factor	Homo sapiens	12-15
8123570-5	1994	The latter inhibitory effect of NGF was abrogated by co-incubation with neutralizing anti-NGF antibodies or with the protein kinase C inhibitor staurosporine.	Staurosporine	144-157	nerve growth factor	Mus musculus	32-35
8113023-11	1994	Thrombin-induced intercellular gap formation was blocked by preincubation with forskolin (14.6 +/- 7.1 gaps/f), staurosporine (10.2 +/- 5.0 gaps/f), or H-7 (24.5 +/- 9.8 gaps/f).	Staurosporine	112-125	coagulation factor II, thrombin	Bos taurus	0-8
7905502-6	1994	The protein kinase C inhibitors staurosporin and calphostin C inhibited both the TNF-, PMA-, and adherence-induced release of soluble forms of TNFRs.	Staurosporine	32-44	tumor necrosis factor	Homo sapiens	81-84
7507209-6	1994	The increased AP1 binding observed in the presence of pX was unaffected by the protein kinase C inhibitors calphostin C and sphingosine and by the protein kinase A inhibitor HA1004, while it was almost completely blocked by staurosporine, a potent and nonspecific protein kinase inhibitor, suggesting that protein kinase C- and A-independent phosphorylation events might play a role in the phenomenon.	Staurosporine	224-237	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-17
8307162-4	1994	By contrast, the eEF-2 kinase is rather resistant towards the potent but non-selective protein kinase inhibitor staurosporine (IC50 &gt; 50 microM) and thus can be differentiated from most other protein kinases that are suppressed by staurosporine in the nM range.	Staurosporine	112-125	eukaryotic elongation factor 2 kinase	Homo sapiens	17-29
8307162-4	1994	By contrast, the eEF-2 kinase is rather resistant towards the potent but non-selective protein kinase inhibitor staurosporine (IC50 &gt; 50 microM) and thus can be differentiated from most other protein kinases that are suppressed by staurosporine in the nM range.	Staurosporine	234-247	eukaryotic elongation factor 2 kinase	Homo sapiens	17-29
8288577-1	1994	A staurosporine-sensitive mutation (stt1) in yeast has been found in the PKC1 gene that encodes a protein kinase C homologue (Yoshida, S., Ikeda, E., Uno, I., and Mitsuzawa, H. (1992) Mol.	Staurosporine	2-15	protein kinase C	Saccharomyces cerevisiae S288C	36-40
8288577-1	1994	A staurosporine-sensitive mutation (stt1) in yeast has been found in the PKC1 gene that encodes a protein kinase C homologue (Yoshida, S., Ikeda, E., Uno, I., and Mitsuzawa, H. (1992) Mol.	Staurosporine	2-15	protein kinase C	Saccharomyces cerevisiae S288C	73-77
8288577-4	1994	We report here another staurosporine-sensitive mutant, stt4, which shows very similar phenotypes to that of the stt1 mutant.	Staurosporine	23-36	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	55-59
8288577-4	1994	We report here another staurosporine-sensitive mutant, stt4, which shows very similar phenotypes to that of the stt1 mutant.	Staurosporine	23-36	protein kinase C	Saccharomyces cerevisiae S288C	112-116
8288577-6	1994	Staurosporine sensitivity of the stt4 mutant was suppressed by overexpression of PKC1/STT1, indicating genetic interaction between stt4 and pkc1/stt1.	Staurosporine	0-13	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	33-37
8288577-6	1994	Staurosporine sensitivity of the stt4 mutant was suppressed by overexpression of PKC1/STT1, indicating genetic interaction between stt4 and pkc1/stt1.	Staurosporine	0-13	protein kinase C	Saccharomyces cerevisiae S288C	81-85
8288577-6	1994	Staurosporine sensitivity of the stt4 mutant was suppressed by overexpression of PKC1/STT1, indicating genetic interaction between stt4 and pkc1/stt1.	Staurosporine	0-13	protein kinase C	Saccharomyces cerevisiae S288C	86-90
8288577-6	1994	Staurosporine sensitivity of the stt4 mutant was suppressed by overexpression of PKC1/STT1, indicating genetic interaction between stt4 and pkc1/stt1.	Staurosporine	0-13	1-phosphatidylinositol 4-kinase STT4	Saccharomyces cerevisiae S288C	131-135
8288577-6	1994	Staurosporine sensitivity of the stt4 mutant was suppressed by overexpression of PKC1/STT1, indicating genetic interaction between stt4 and pkc1/stt1.	Staurosporine	0-13	protein kinase C	Saccharomyces cerevisiae S288C	140-144
8288577-6	1994	Staurosporine sensitivity of the stt4 mutant was suppressed by overexpression of PKC1/STT1, indicating genetic interaction between stt4 and pkc1/stt1.	Staurosporine	0-13	protein kinase C	Saccharomyces cerevisiae S288C	145-149
8276122-7	1994	The effect of IFNs on the TNF receptors was inhibited by staurosporin, a protein kinase C (PK-C) inhibitor.	Staurosporine	57-69	proline rich transmembrane protein 2	Homo sapiens	73-89
8276122-7	1994	The effect of IFNs on the TNF receptors was inhibited by staurosporin, a protein kinase C (PK-C) inhibitor.	Staurosporine	57-69	proline rich transmembrane protein 2	Homo sapiens	91-95
8276122-7	1994	The effect of IFNs on the TNF receptors was inhibited by staurosporin, a protein kinase C (PK-C) inhibitor.	Staurosporine	57-69	tumor necrosis factor	Homo sapiens	26-29
8304470-12	1994	Imipramine, fluoxetine, staurosporine, and cholera toxin inhibited the stimulations of both DNA synthesis and c-myc and actin mRNA expressions by 5-HT.	Staurosporine	24-37	MYC proto-oncogene, bHLH transcription factor	Bos taurus	110-115
8974323-6	1994	These events were mediated via muscarinic M1 receptors and the inhibitory effects of H7, staurosporin, and RO31-7549 on the c-fos expression indicated that it was mediated via protein kinase C. Acute exposure to 100 mM ethanol inhibited the formation of IP3 and the expression of c-fos.	Staurosporine	89-101	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	124-129
8280110-7	1994	The separate chelation of Ca2+i (30 microM BAPTA-AM) or inhibition of PKC (1 microM staurosporine) induced about 50% inhibition of the pHi responses triggered by TRAP, trypsin, gamma- and alpha-thrombin, but the combination induced complete inhibition.	Staurosporine	84-97	glucose-6-phosphate isomerase	Homo sapiens	135-138
7516691-4	1994	Besides employing TPA directly, the synergistic effect of TNF could be traced back to protein kinase C activation since protein kinase C inhibitors (IC50 value for staurosporine: 4 nM) potently suppressed nitrite production in the case of IL-1/TNF administration.	Staurosporine	164-177	tumor necrosis factor	Rattus norvegicus	58-61
7516691-4	1994	Besides employing TPA directly, the synergistic effect of TNF could be traced back to protein kinase C activation since protein kinase C inhibitors (IC50 value for staurosporine: 4 nM) potently suppressed nitrite production in the case of IL-1/TNF administration.	Staurosporine	164-177	tumor necrosis factor	Rattus norvegicus	239-247
7904541-4	1994	Thus, the inhibitors H-7, staurosporine, and genistein exerted a dose-dependent inhibition of CD2 up-regulation, CD25 expression, IL-2 production, and cellular proliferation.	Staurosporine	26-39	CD2 molecule	Homo sapiens	94-97
7904541-4	1994	Thus, the inhibitors H-7, staurosporine, and genistein exerted a dose-dependent inhibition of CD2 up-regulation, CD25 expression, IL-2 production, and cellular proliferation.	Staurosporine	26-39	interleukin 2 receptor subunit alpha	Homo sapiens	113-117
7904541-4	1994	Thus, the inhibitors H-7, staurosporine, and genistein exerted a dose-dependent inhibition of CD2 up-regulation, CD25 expression, IL-2 production, and cellular proliferation.	Staurosporine	26-39	interleukin 2	Homo sapiens	130-134
8280110-7	1994	The separate chelation of Ca2+i (30 microM BAPTA-AM) or inhibition of PKC (1 microM staurosporine) induced about 50% inhibition of the pHi responses triggered by TRAP, trypsin, gamma- and alpha-thrombin, but the combination induced complete inhibition.	Staurosporine	84-97	TRAP	Homo sapiens	162-166
8261585-8	1994	Activation of the current was abolished in the presence of the PKC inhibitor staurosporine (2.5 mumol/L).	Staurosporine	77-90	Prkca	Cavia porcellus	63-66
8137877-5	1994	The depression of the Ca2+ channel current by interleukin-1 beta was prevented by the extracellular application of pertussis toxin, and by the intracellular application of GDP[beta S], H-7, staurosporine or bisindolylmaleimide.	Staurosporine	190-203	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	22-25
8137877-5	1994	The depression of the Ca2+ channel current by interleukin-1 beta was prevented by the extracellular application of pertussis toxin, and by the intracellular application of GDP[beta S], H-7, staurosporine or bisindolylmaleimide.	Staurosporine	190-203	interleukin-1 beta	Cavia porcellus	46-64
7506699-7	1994	The effects of insulin were almost completely inhibited by diltiazem, staurosporine, calphostin C, and thapsigargin.	Staurosporine	70-83	insulin	Homo sapiens	15-22
7505275-5	1994	Staurosporine, a potent PKC inhibitor with affinity for the catalytic domain of PKC, inhibited phosphorylation of the 80 K protein and 12-O-tetradecanoyl-13-phorbol acetate induction of EGF receptor phosphorylation but did not inhibit the calphostin-C induction of the EGF receptor phosphorylation.	Staurosporine	0-13	epidermal growth factor receptor	Homo sapiens	186-198
7505275-5	1994	Staurosporine, a potent PKC inhibitor with affinity for the catalytic domain of PKC, inhibited phosphorylation of the 80 K protein and 12-O-tetradecanoyl-13-phorbol acetate induction of EGF receptor phosphorylation but did not inhibit the calphostin-C induction of the EGF receptor phosphorylation.	Staurosporine	0-13	epidermal growth factor receptor	Homo sapiens	269-281
7949466-10	1994	Staurosporine inhibited the effects of PMA on the phosphorylation of P-glycoprotein and on the accumulation of vinblastine.	Staurosporine	0-13	ATP binding cassette subfamily B member 1	Homo sapiens	69-83
7517488-9	1994	Higher doses of staurosporine (500 nM) resulted in complete blockage of the thrombin-induced increase in F-actin.	Staurosporine	16-29	coagulation factor II, thrombin	Homo sapiens	76-84
7939136-2	1994	This was associated with a staurosporine-resistant increase in p55 soluble TNFR levels, in culture media, suggesting that down-modulation was due to enhanced receptor shedding via a protein kinase C-independent mechanism.	Staurosporine	27-40	TNF receptor superfamily member 1A	Homo sapiens	63-66
8288587-5	1994	PKC inhibitors H7 and staurosporine block both bryostatin 1- and interleukin-3-mediated Raf-1 phosphorylation and FDC-P1 cell proliferation.	Staurosporine	22-35	v-raf-leukemia viral oncogene 1	Mus musculus	88-93
7939136-2	1994	This was associated with a staurosporine-resistant increase in p55 soluble TNFR levels, in culture media, suggesting that down-modulation was due to enhanced receptor shedding via a protein kinase C-independent mechanism.	Staurosporine	27-40	TNF receptor superfamily member 1A	Homo sapiens	75-79
7863544-3	1994	CD8+ splenocytes triggered by anti-Ti mAb internalize the ligand-TCR/CD3 complex at a low rate, through a mechanism inhibited by the protein tyrosine kinase (PTK) inhibitor genistein and by staurosporine, a potent but non selective protein kinase C (PKC) inhibitor.	Staurosporine	190-203	CD3 antigen, epsilon polypeptide	Mus musculus	69-72
8262925-4	1993	Inhibition by fMLP was prevented by chelerythrine but only partially by staurosporin.	Staurosporine	72-84	formyl peptide receptor 1	Homo sapiens	14-18
8146021-6	1994	A dose-dependent inhibition of EPO mRNA formation, independent of effects on total RNA synthesis, as determined by [3H]uridine incorporation, was also found in the presence of the kinase inhibitor staurosporine (ED50 approximately 2 x 10(-8) M) and three structurally related derivatives with increased selectivity for PKC (RO 317549, ED50 approximately 1 x 10(-6) M; RO 318220, ED50 approximately 1 x 10(-6) M and CGP 41251, ED50 approximately 4 x 10(-6) M).	Staurosporine	197-210	erythropoietin	Rattus norvegicus	31-34
8146021-6	1994	A dose-dependent inhibition of EPO mRNA formation, independent of effects on total RNA synthesis, as determined by [3H]uridine incorporation, was also found in the presence of the kinase inhibitor staurosporine (ED50 approximately 2 x 10(-8) M) and three structurally related derivatives with increased selectivity for PKC (RO 317549, ED50 approximately 1 x 10(-6) M; RO 318220, ED50 approximately 1 x 10(-6) M and CGP 41251, ED50 approximately 4 x 10(-6) M).	Staurosporine	197-210	protein kinase C, alpha	Rattus norvegicus	319-322
8146021-7	1994	The markedly lower potency of the latter three compounds as compared to staurosporine suggests that this suppression of EPO gene induction was not mediated by inhibition of PKC.	Staurosporine	72-85	erythropoietin	Rattus norvegicus	120-123
8258685-5	1993	Protein kinase C inhibition by staurosporine reduced LPS induction of TNF-alpha, whereas it had no effects on IL-6 and IL-1 beta.	Staurosporine	31-44	tumor necrosis factor	Homo sapiens	70-79
8253722-6	1993	The protein kinase inhibitor staurosporine was able to induce differentiation in v-rasHa keratinocytes and benign tumor cell lines, and concomitantly tyrosine phosphorylation of PKC delta decreased.	Staurosporine	29-42	protein kinase C, delta	Mus musculus	178-187
8268245-2	1993	IL-1 and a protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA) augmented the production of proMMP-1 (interstitial procollagenase), proMMP-3 (prostromelysin-1) and TIMP-1, but their effects were inhibited by the protein kinase C inhibitors 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) and staurosporine in a dose-dependent manner.	Staurosporine	330-343	interleukin 1 alpha	Homo sapiens	0-4
8258697-3	1993	The protein kinase inhibitor staurosporine inhibited constitutive phosphorylation and blocked inducible shedding of TNFR80, suggesting that phosphorylation may be important for cleavage of the extracellular domain.	Staurosporine	29-42	TNF receptor superfamily member 1B	Homo sapiens	116-122
8109190-3	1993	Staurosporin (10 nmol/l), an inhibitor of protein kinase C, significantly reduced the [3H]dopamine release induced by prolactin (1 mg/l).	Staurosporine	0-12	prolactin	Rattus norvegicus	118-127
8268245-3	1993	The suppressive effect of H-7 and staurosporine on the IL-1-induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs.	Staurosporine	34-47	interleukin 1 alpha	Homo sapiens	55-59
8268245-3	1993	The suppressive effect of H-7 and staurosporine on the IL-1-induced production of proMMPs-1 and -3 and TIMP-1 resulted from the decrease in the steady-state levels of their mRNAs.	Staurosporine	34-47	TIMP metallopeptidase inhibitor 1	Homo sapiens	103-109
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Staurosporine	41-54	interleukin 1 alpha	Homo sapiens	74-78
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Staurosporine	41-54	interleukin 1 alpha	Homo sapiens	171-175
8268245-8	1993	However, the treatment of the cells with staurosporine in the presence of IL-1 or TPA further augmented PGE2 synthesis, suggesting that the increased synthesis of PGE2 by IL-1 treatment is mediated via signalling pathways distinct from those of proMMPs-1 and -3 and TIMP-1.	Staurosporine	41-54	TIMP metallopeptidase inhibitor 1	Homo sapiens	266-272
8279529-6	1993	The results with staurosporine and low NiCl2 concentrations are in agreement in that increases in intracellular Ca2+ concentration and protein kinase C activation are necessary for full platelet activation mediated by thrombin.	Staurosporine	17-30	coagulation factor II, thrombin	Homo sapiens	218-226
8227076-9	1993	The proximal cascade leading to Raf kinase activation may involve a protein kinase activity was severely attenuated by stimulated kinase activity was severely attenuated by previous phorbol ester treatment for 20 h or staurosporine pretreatment.	Staurosporine	218-231	zinc fingers and homeoboxes 2	Mus musculus	32-35
8119663-5	1993	Pretreatment with 50 uM H-7 or 1 nM staurosporine, inhibitors of PKC, significantly blocked the PTHrP (10(-9) to 10(-7) M)-induced inhibition of DNA synthesis.	Staurosporine	36-49	parathyroid hormone like hormone	Homo sapiens	96-101
7504096-7	1993	Staurosporine, a protein kinase C (PKC) inhibitor, inhibited oxyHb-induced endothelin-1 production in both vascular endothelial and smooth-muscle cells, whereas an increase of intracellular cyclic adenosine monophosphate (cAMP) by forskolin or an addition of 8-bromo-cAMP only inhibited this effect in smooth-muscle cells.	Staurosporine	0-13	endothelin 1	Rattus norvegicus	75-87
7504465-2	1993	TNF induced metalloproteinase transcription could be inhibited with either protein kinase inhibitors (H7 or staurosporine) or by raising intracellular cAMP levels.	Staurosporine	108-121	tumor necrosis factor	Homo sapiens	0-3
8282136-10	1993	Similarly, staurosporin inhibited the IL-1-induced PGE2 production in MC in a dose dependent manner.	Staurosporine	11-23	interleukin 1 complex	Mus musculus	38-42
8226891-1	1993	Activation of the neutrophil respiratory burst oxidase involves phosphorylation-dependent translocation of the cytosolic proteins p47phox and p67phox to the plasma membrane, a process in intact cells that is inhibited by staurosporine.	Staurosporine	221-234	neutrophil cytosolic factor 1	Homo sapiens	130-137
8226971-7	1993	The protein kinase C inhibitor staurosporine did not inhibit phosphorylation of ET-FR but blocked the fast migrating component of phosphorylated ET-C5aR.	Staurosporine	31-44	complement C5a receptor 1	Rattus norvegicus	148-152
7510053-4	1993	It also occurred in slices treated with either staurosporine (1 microM), which is a potent inhibitor of a variety of protein kinases including protein kinase C (PKC), or thapsigargin (10 microM), which depletes intracellular Ca2+ stores by preventing their refilling.	Staurosporine	47-60	carbonic anhydrase 2	Rattus norvegicus	225-228
7510425-5	1993	Both LPS- and PMA-induced TF activity were inhibited, in a concentration dependent manner, by three different PKC inhibitors: H7, staurosporine and calphostin C.	Staurosporine	130-143	coagulation factor III, tissue factor	Homo sapiens	26-28
7510425-6	1993	TF antigen determination confirmed that LPS-induced cell-surface TF protein levels decreased in parallel to TF functional activity under staurosporine treatment.	Staurosporine	137-150	coagulation factor III, tissue factor	Homo sapiens	0-2
7510425-6	1993	TF antigen determination confirmed that LPS-induced cell-surface TF protein levels decreased in parallel to TF functional activity under staurosporine treatment.	Staurosporine	137-150	coagulation factor III, tissue factor	Homo sapiens	65-67
7510425-6	1993	TF antigen determination confirmed that LPS-induced cell-surface TF protein levels decreased in parallel to TF functional activity under staurosporine treatment.	Staurosporine	137-150	coagulation factor III, tissue factor	Homo sapiens	65-67
7510425-7	1993	Moreover, Northern blot analysis of total RNA from LPS- or PMA-stimulated monocytes showed a concentration-dependent decrease in TF mRNA levels in response to H7 and staurosporine.	Staurosporine	166-179	coagulation factor III, tissue factor	Homo sapiens	129-131
8226891-1	1993	Activation of the neutrophil respiratory burst oxidase involves phosphorylation-dependent translocation of the cytosolic proteins p47phox and p67phox to the plasma membrane, a process in intact cells that is inhibited by staurosporine.	Staurosporine	221-234	neutrophil cytosolic factor 2	Homo sapiens	142-149
8226891-2	1993	We now report that in a cell-free oxidase system, staurosporine and protein kinase C pseudosubstrate PKC(19-36) both inhibited p47phox phosphorylation but had no effect on superoxide generation.	Staurosporine	50-63	neutrophil cytosolic factor 1	Homo sapiens	127-134
8219237-3	1993	In this study, we reassessed these PMN responses in fMLP-stimulated cells and found that staurosporine had opposite effects depending on the duration of PMN treatment with staurosporine.	Staurosporine	89-102	formyl peptide receptor 1	Homo sapiens	52-56
8238492-3	1993	The protein kinase C (PKC) inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, staurosporine, and PKC inhibitor peptide, inhibited such stimulation.	Staurosporine	87-100	protein kinase C, gamma	Rattus norvegicus	4-20
8238492-3	1993	The protein kinase C (PKC) inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, staurosporine, and PKC inhibitor peptide, inhibited such stimulation.	Staurosporine	87-100	protein kinase C, gamma	Rattus norvegicus	22-25
8219221-8	1993	Involvement of protein kinase C (PKC) in the PC-Al-induced enhancement of TF activity was suggested by experiments in which staurosporine, an inhibitor of PKC, suppressed the activity of PC-Al.	Staurosporine	124-137	coagulation factor III, tissue factor	Homo sapiens	74-76
8299848-3	1993	Degranulation triggered by these ligands was inhibited by the protein kinase C (pkC) inhibitor staurosporine or by the tyrosine kinase inhibitor herbimycin A.	Staurosporine	95-108	proline rich transmembrane protein 2	Homo sapiens	62-78
8299848-3	1993	Degranulation triggered by these ligands was inhibited by the protein kinase C (pkC) inhibitor staurosporine or by the tyrosine kinase inhibitor herbimycin A.	Staurosporine	95-108	proline rich transmembrane protein 2	Homo sapiens	80-83
8404660-7	1993	3) Inhibition of PKC by either H-7 [1-(5-isoquinolinilsulfonyl)2-methylpiperazine] or staurosporine inhibited all of the alpha 1-adrenoceptor-induced responses, except gluconeogenesis.	Staurosporine	86-99	protein kinase C, gamma	Rattus norvegicus	17-20
8219237-4	1993	Short PMN incubation (0.5 to 3 minutes) with 25 to 100 nmol/L staurosporine inhibited the fMLP-induced RB, whereas longer treatment (15 to 20 minutes) enhanced it by up to about 200% relative to controls.	Staurosporine	62-75	formyl peptide receptor 1	Homo sapiens	90-94
8219237-8	1993	Analysis of 32P-phosphorylated proteins in fMLP-stimulated cells showed that short PMN treatment (&lt; 8 minutes) with staurosporine abolished the phosphorylation of the 47-kD protein, which was identified as p47 phox, whereas long treatment partially restored p47 phox phosphorylation up to approximately 50% of the control value.	Staurosporine	119-132	formyl peptide receptor 1	Homo sapiens	43-47
8219237-8	1993	Analysis of 32P-phosphorylated proteins in fMLP-stimulated cells showed that short PMN treatment (&lt; 8 minutes) with staurosporine abolished the phosphorylation of the 47-kD protein, which was identified as p47 phox, whereas long treatment partially restored p47 phox phosphorylation up to approximately 50% of the control value.	Staurosporine	119-132	pleckstrin	Homo sapiens	209-212
8219237-8	1993	Analysis of 32P-phosphorylated proteins in fMLP-stimulated cells showed that short PMN treatment (&lt; 8 minutes) with staurosporine abolished the phosphorylation of the 47-kD protein, which was identified as p47 phox, whereas long treatment partially restored p47 phox phosphorylation up to approximately 50% of the control value.	Staurosporine	119-132	pleckstrin	Homo sapiens	261-264
8219237-11	1993	Thus, in addition to its known depressive effect, staurosporine markedly potentiated fMLP-stimulated RB as a function of the duration of PMN treatment.	Staurosporine	50-63	formyl peptide receptor 1	Homo sapiens	85-89
8219237-12	1993	The restoration of p47 phox phosphorylation suggests that staurosporine may alter the interactions between different protein kinases, producing marked time-dependent changes in signalling pathways.	Staurosporine	58-71	pleckstrin	Homo sapiens	19-22
8224186-4	1993	All four cell lines continued to proliferate although at reduced rates in the presence of the PKC inhibitors staurosporine and H-7.	Staurosporine	109-122	protein kinase C alpha	Homo sapiens	94-97
7507092-12	1993	CD43 mAb-induced burst formation differed from adhesion induction in that it could be additionally inhibited with staurosporine and lavendustin A.	Staurosporine	114-127	sialophorin	Homo sapiens	0-4
8143907-11	1993	The inhibitory actions of PGF2 alpha and 4 beta PMA on hLH-stimulated progesterone production were abolished in the presence of the PKC inhibitor, staurosporine.	Staurosporine	147-160	proline rich transmembrane protein 2	Homo sapiens	132-135
8134292-6	1993	Staurosporine, an inhibitor of protein kinase C, totally abolished the basal as well as the gastrin-stimulated activity of protein kinase C. The tumor promoter phorbol 12-myristate 13-acetate also stimulated colonic epithelial protein kinase C. However, prolonged treatment of cells with phorbol inhibited their subsequent response to gastrin stimulation.	Staurosporine	0-13	gastrin	Rattus norvegicus	92-99
8134292-6	1993	Staurosporine, an inhibitor of protein kinase C, totally abolished the basal as well as the gastrin-stimulated activity of protein kinase C. The tumor promoter phorbol 12-myristate 13-acetate also stimulated colonic epithelial protein kinase C. However, prolonged treatment of cells with phorbol inhibited their subsequent response to gastrin stimulation.	Staurosporine	0-13	gastrin	Rattus norvegicus	335-342
7693670-8	1993	L-364,718 blocked the effect of CCK, and staurosporine blocked the effects of TPA and partially blocked the effect of CCK.	Staurosporine	41-54	cholecystokinin	Homo sapiens	118-121
8226736-2	1993	Treatment of fibroblasts with kinase inhibitors (ML-7, H7, HA1004, calphostin C, and staurosporine) resulted in the rapid decrease in the binding of 125I-labeled plasma Fn and iodinated amino-terminal fragments of Fn.	Staurosporine	85-98	fibronectin 1	Homo sapiens	169-171
8226736-2	1993	Treatment of fibroblasts with kinase inhibitors (ML-7, H7, HA1004, calphostin C, and staurosporine) resulted in the rapid decrease in the binding of 125I-labeled plasma Fn and iodinated amino-terminal fragments of Fn.	Staurosporine	85-98	fibronectin 1	Homo sapiens	214-216
8404601-11	1993	Concurrent administration of staurosporine, a protein kinase C inhibitor, at 10(-6) M significantly inhibited Ang II-stimulated meiotic maturation of ovulated ova and follicular oocytes.	Staurosporine	29-42	angiogenin	Oryctolagus cuniculus	110-113
8407943-3	1993	Staurosporine abolished the enhanced phosphorylation in response to IL-1 for some of these proteins, suggesting that protein kinase C (PKC) was at least partially responsible.	Staurosporine	0-13	interleukin 1 complex	Mus musculus	68-72
8407943-3	1993	Staurosporine abolished the enhanced phosphorylation in response to IL-1 for some of these proteins, suggesting that protein kinase C (PKC) was at least partially responsible.	Staurosporine	0-13	protein kinase C, beta	Mus musculus	135-138
8238319-3	1993	Inhibition of PKC by staurosporine or downregulation of PKC by PMA pretreatment abolished AVP-induced stimulation of p42MAPK.	Staurosporine	21-34	arginine vasopressin	Homo sapiens	90-93
8264660-7	1993	BNP mRNA increased 6-fold by 3 h of PMA treatment and remained elevated above control levels for 48 h. Staurosporine prevented the increase in BNP mRNA.	Staurosporine	103-116	natriuretic peptide B	Rattus norvegicus	0-3
8262550-4	1993	In addition, increased phosphorylation of CD27 in T-cell activation either via CD2 or CD3 pathways was strongly suppressed by a cyclic nucleotide-dependent kinase inhibitor, H-8, but only slightly by a protein kinase C inhibitor, staurosporine.	Staurosporine	230-243	CD27 molecule	Homo sapiens	42-46
8262550-4	1993	In addition, increased phosphorylation of CD27 in T-cell activation either via CD2 or CD3 pathways was strongly suppressed by a cyclic nucleotide-dependent kinase inhibitor, H-8, but only slightly by a protein kinase C inhibitor, staurosporine.	Staurosporine	230-243	CD2 molecule	Homo sapiens	42-45
8408228-2	1993	The reduction in EGF binding by bradykinin, ATP, and TPA was similarly reversed by concomitant incubation with staurosporine, a protein kinase C inhibitor, implying that the phosphorylation of EGF receptors was catalyzed probably by a protein kinase C of the same or similar type in each case.	Staurosporine	111-124	kininogen 1	Homo sapiens	32-42
8410184-10	1993	In contrast, staurosporine, a broadly acting kinase inhibitor, inhibited the neuroprotective effect of NGF, but not of EGF or FGF.	Staurosporine	13-26	nerve growth factor	Rattus norvegicus	103-106
8264660-7	1993	BNP mRNA increased 6-fold by 3 h of PMA treatment and remained elevated above control levels for 48 h. Staurosporine prevented the increase in BNP mRNA.	Staurosporine	103-116	natriuretic peptide B	Rattus norvegicus	143-146
8134908-3	1993	On the contrary, staurosporine, a highly potent, non-selective PKC inhibitor, simultaneously abolished tissue factor expression and thrombomodulin down-regulation induced by endotoxin, IL1 beta and TNF alpha.	Staurosporine	17-30	interleukin 1 beta	Bos taurus	185-193
8143904-4	1993	The protein kinase inhibitor, staurosporine at 1 and 10 nM, impaired TNF-induced TIC clustering for 6 days, as did the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H-7); conversely, the protein kinase inhibitor, chelerythrine chloride (0.1, 1.0 or 10 microM), did not attenuate TNF-directed clustering.	Staurosporine	30-43	tumor necrosis factor	Rattus norvegicus	69-72
8134908-3	1993	On the contrary, staurosporine, a highly potent, non-selective PKC inhibitor, simultaneously abolished tissue factor expression and thrombomodulin down-regulation induced by endotoxin, IL1 beta and TNF alpha.	Staurosporine	17-30	tumor necrosis factor	Bos taurus	198-207
8143904-4	1993	The protein kinase inhibitor, staurosporine at 1 and 10 nM, impaired TNF-induced TIC clustering for 6 days, as did the protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperizine dihydrochloride (H-7); conversely, the protein kinase inhibitor, chelerythrine chloride (0.1, 1.0 or 10 microM), did not attenuate TNF-directed clustering.	Staurosporine	30-43	tumor necrosis factor	Rattus norvegicus	322-325
7690250-5	1993	Impaired transport of rhodamine in normal T lymphocytes treated with staurosporine demonstrates that modulation of P-glycoprotein function is not limited to cells selected for drug resistance in vitro.	Staurosporine	69-82	ATP binding cassette subfamily B member 1	Homo sapiens	115-129
8365480-1	1993	The potent inhibitors of protein kinase C (PKC), H7, staurosporine, and staurosporine derivatives, were examined for their inhibitory effects on novel PKC (nPKC) isozymes delta and epsilon.	Staurosporine	53-66	protein kinase C delta	Homo sapiens	151-154
8365480-1	1993	The potent inhibitors of protein kinase C (PKC), H7, staurosporine, and staurosporine derivatives, were examined for their inhibitory effects on novel PKC (nPKC) isozymes delta and epsilon.	Staurosporine	72-85	protein kinase C delta	Homo sapiens	151-154
8365480-2	1993	H7 and staurosporine, usually used as selective inhibitors of PKC, showed similar inhibitory effects on cPKC (a mixture of cPKC alpha, beta, and gamma) and nPKC delta and epsilon.	Staurosporine	7-20	protein kinase C delta	Homo sapiens	62-65
8365480-2	1993	H7 and staurosporine, usually used as selective inhibitors of PKC, showed similar inhibitory effects on cPKC (a mixture of cPKC alpha, beta, and gamma) and nPKC delta and epsilon.	Staurosporine	7-20	protein kinase C delta	Homo sapiens	123-166
8103710-6	1993	Comparative studies showed that GF109203X and staurosporine had similar inhibitory effects on the upregulation of activated CD4+ T cell adhesion.	Staurosporine	46-59	CD4 molecule	Homo sapiens	124-127
8214045-7	1993	Two PKC inhibitors [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and staurosporine] equally blocked PTH- and PTHRP-stimulated MNC formation.	Staurosporine	87-100	parathyroid hormone	Homo sapiens	118-121
8214045-7	1993	Two PKC inhibitors [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride and staurosporine] equally blocked PTH- and PTHRP-stimulated MNC formation.	Staurosporine	87-100	parathyroid hormone like hormone	Homo sapiens	127-132
8220902-9	1993	Exposure of AG04762 cells for 10 min to staurosporine produced a concentration-dependent inhibition (IC50 = 107 +/- 14 nM) in bradykinin-stimulated prostacyclin release.	Staurosporine	40-53	kininogen 1	Bos taurus	126-136
8358721-11	1993	Staurosporine, a PKC inhibitor, reduced the TPA enhancing effect in neoplastic thyrocytes and cancelled TPA inhibition in normal cells.	Staurosporine	0-13	plasminogen activator, tissue type	Homo sapiens	44-47
8358721-11	1993	Staurosporine, a PKC inhibitor, reduced the TPA enhancing effect in neoplastic thyrocytes and cancelled TPA inhibition in normal cells.	Staurosporine	0-13	plasminogen activator, tissue type	Homo sapiens	104-107
8358721-12	1993	Moreover, when added to IFN-gamma without TPA in normal thyroid cells, staurosporine increased 3- to 4-fold the amount of HLA-DR.	Staurosporine	71-84	interferon gamma	Homo sapiens	24-33
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 1 beta	Homo sapiens	81-85
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 6	Homo sapiens	94-98
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 1 beta	Homo sapiens	109-113
8245177-2	1993	Furthermore, in monocytes, protein kinase C (PKC) activation by PMA even reduced IL-1-induced IL-6 mRNA, and IL-1-induced IL-6 synthesis was increased by the PKC inhibitor staurosporine.	Staurosporine	172-185	interleukin 6	Homo sapiens	122-126
7690398-9	1993	Pretreatment with 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine and staurosporine, PKC inhibitors, markedly inhibited the late component of the PIE of ET-1 without affecting the early component.	Staurosporine	70-83	endothelin-1	Cavia porcellus	153-157
8230323-7	1993	Inhibitors of PKC activity (H-7, H-8, sphingosine, and staurosporine) also were neuroprotective.	Staurosporine	55-68	proline rich transmembrane protein 2	Homo sapiens	14-17
7694878-7	1993	The protein kinase C (PKC) inhibitor staurosporine inhibited both PDBu-induced LH release and GH release.	Staurosporine	37-50	protein kinase C, gamma	Rattus norvegicus	4-20
7694878-7	1993	The protein kinase C (PKC) inhibitor staurosporine inhibited both PDBu-induced LH release and GH release.	Staurosporine	37-50	protein kinase C, gamma	Rattus norvegicus	22-25
7694878-12	1993	Data obtained in 45Ca2+ influx experiments further suggested that a staurosporine-sensitive, but H7-resistant, PKC-like kinase may tonically maintain L-channels in a voltage-sensitive state, as down-regulation of PKC in dispersed anterior pituitary cells by long term PDBu treatment caused a significant reduction in K(+)-induced 45Ca2+ influx.	Staurosporine	68-81	protein kinase C, gamma	Rattus norvegicus	111-114
7694878-12	1993	Data obtained in 45Ca2+ influx experiments further suggested that a staurosporine-sensitive, but H7-resistant, PKC-like kinase may tonically maintain L-channels in a voltage-sensitive state, as down-regulation of PKC in dispersed anterior pituitary cells by long term PDBu treatment caused a significant reduction in K(+)-induced 45Ca2+ influx.	Staurosporine	68-81	protein kinase C, gamma	Rattus norvegicus	213-216
8368285-5	1993	The PKC inhibitors H-7 and staurosporine did not decrease ET-1-stimulated aldosterone secretion, but they inhibited the potentiation effect of ET-1 on ANG II-mediated aldosterone secretion.	Staurosporine	27-40	endothelin 1	Bos taurus	143-147
8375736-6	1993	The fact that H7, H8, and staurosporine, but not HA1004, blocked the induction of cytolytic activity by IFN alpha provides additional evidence of the involvement of PKC in this activity.	Staurosporine	26-39	interferon alpha 1	Homo sapiens	104-113
8398806-7	1993	The respiratory burst elicited by MDF was abrogated by staurosporine, indicating that neutrophil activation and signal transduction by MDF and FMLP are dependent on protein kinase C.	Staurosporine	55-68	formyl peptide receptor 1	Homo sapiens	143-147
7687659-0	1993	Staurosporine activates a 60,000 M(r) protein kinase in bovine chromaffin cells that phosphorylates myelin basic protein in vitro.	Staurosporine	0-13	myelin basic protein	Bos taurus	100-120
7687659-2	1993	One of these, a 60,000 M(r) kinase (PK60) that phosphorylated myelin basic protein in vitro, was activated fourfold when cells were treated with the protein kinase inhibitor staurosporine.	Staurosporine	174-187	myelin basic protein	Bos taurus	62-82
7687659-9	1993	Moreover, staurosporine activated PK60 in cells depleted of protein kinase C alpha and epsilon; thus, staurosporine appeared to activate PK60 by a mechanism that does not require these protein kinase C isoforms.	Staurosporine	10-23	protein kinase C alpha	Bos taurus	60-82
7687659-9	1993	Moreover, staurosporine activated PK60 in cells depleted of protein kinase C alpha and epsilon; thus, staurosporine appeared to activate PK60 by a mechanism that does not require these protein kinase C isoforms.	Staurosporine	102-115	protein kinase C alpha	Bos taurus	60-82
8263960-6	1993	In the presence of the protein kinase C inhibitor staurosporine, both the agonist and phorbol ester induced decreases in ET-1 mediated PI turnover were reversed.	Staurosporine	50-63	endothelin 1	Canis lupus familiaris	121-125
8263960-7	1993	Staurosporine even potentiated (75%) ET-1 induced PI turnover despite ET-1 and PMA pretreatments.	Staurosporine	0-13	endothelin 1	Canis lupus familiaris	37-41
7689100-3	1993	Pretreatment of A431 cells with genistein, a putative tyrosine kinase inhibitor, abolished the ability of PAF to activate PLC, whereas pretreatment with staurosporine, a protein kinase C inhibitor, potentiated the ability of PAF to activate PLC.	Staurosporine	153-166	PCNA clamp associated factor	Homo sapiens	225-228
7689100-3	1993	Pretreatment of A431 cells with genistein, a putative tyrosine kinase inhibitor, abolished the ability of PAF to activate PLC, whereas pretreatment with staurosporine, a protein kinase C inhibitor, potentiated the ability of PAF to activate PLC.	Staurosporine	153-166	heparan sulfate proteoglycan 2	Homo sapiens	241-244
7689128-2	1993	Protein kinase C inhibitors (H-7 and staurosporine) significantly suppressed this induction of ALP.	Staurosporine	37-50	alkaline phosphatase, placental	Homo sapiens	95-98
8134908-3	1993	On the contrary, staurosporine, a highly potent, non-selective PKC inhibitor, simultaneously abolished tissue factor expression and thrombomodulin down-regulation induced by endotoxin, IL1 beta and TNF alpha.	Staurosporine	17-30	thrombomodulin	Bos taurus	132-146
8393644-0	1993	Alterations in the Ah receptor level after staurosporine treatment.	Staurosporine	43-56	aryl-hydrocarbon receptor	Mus musculus	19-30
8393644-3	1993	Staurosporine, a potent inhibitor of protein kinases inactivates the TCDD-induced CYP1A1 gene transcription.	Staurosporine	0-13	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	82-88
8393644-4	1993	This study was initiated to study binding capacity, capability to translocate, and levels of the AhR in Hepa 1 cells after staurosporine treatment.	Staurosporine	123-136	aryl-hydrocarbon receptor	Mus musculus	97-100
8393644-6	1993	Staurosporine treatment caused a time- and concentration-dependent decrease in the intracellular concentration of AhR.	Staurosporine	0-13	aryl-hydrocarbon receptor	Mus musculus	114-117
8393644-7	1993	At 8 h, the EC50 for the staurosporine-dependent decrease in AhR was 75 nM.	Staurosporine	25-38	aryl-hydrocarbon receptor	Mus musculus	61-64
8394332-6	1993	Basal and guanosine 5"-gamma-(thio)triphosphate/fMLP-stimulated increases in PI3K activity were resistant to changes in free calcium concentrations, staurosporine, acute treatment with phorbol esters, and evidently to permeabilization.	Staurosporine	149-162	formyl peptide receptor 1	Homo sapiens	48-52
8224521-3	1993	Treating the cultures with inhibitors of PKC, staurosporine or H7, a translocation of ANP-containing specific granules from the perinuclear sarcoplasm to the periphery of the myocytes was observed, and furthermore, secretion of ANP was significantly decreased.	Staurosporine	46-59	natriuretic peptide A	Rattus norvegicus	86-89
7901101-4	1993	F and P each induced a time-dependent increase in NPY-mRNA relative abundance, and this was inhibited by staurosporine, an inhibitor of both protein kinase A and C. Cycloheximide (CHX) inhibited F/P induction of mRNA in a time-dependent manner.	Staurosporine	105-118	neuropeptide Y	Rattus norvegicus	50-53
8325843-13	1993	Two inhibitors of PKC, sphingosine and staurosporine, completely blocked the induction of c-fos mRNA by insulin, IGF-I, and TPA.	Staurosporine	39-52	FBJ osteosarcoma oncogene	Mus musculus	90-95
8325843-13	1993	Two inhibitors of PKC, sphingosine and staurosporine, completely blocked the induction of c-fos mRNA by insulin, IGF-I, and TPA.	Staurosporine	39-52	insulin	Gallus gallus	104-111
8325843-13	1993	Two inhibitors of PKC, sphingosine and staurosporine, completely blocked the induction of c-fos mRNA by insulin, IGF-I, and TPA.	Staurosporine	39-52	insulin-like growth factor 1	Mus musculus	113-118
8335905-6	1993	Low concentrations of staurosporine (10 to 20 nM) completely inhibited PMA-mediated activation, but had no effect on CD53-mediated calcium fluxes and inhibited only partially CD53-mediated oxidative burst.	Staurosporine	22-35	CD53 molecule	Homo sapiens	175-179
8335905-7	1993	This suggests that CD53-mediated signaling is largely independent of protein kinase C. CD53-mediated calcium fluxes were inhibited by high concentrations of staurosporine (300 to 500 nM) but not by ADP-ribosylating toxins, suggesting dependence on tyrosine kinases rather than GTP-binding proteins.	Staurosporine	157-170	CD53 molecule	Homo sapiens	19-23
8335905-7	1993	This suggests that CD53-mediated signaling is largely independent of protein kinase C. CD53-mediated calcium fluxes were inhibited by high concentrations of staurosporine (300 to 500 nM) but not by ADP-ribosylating toxins, suggesting dependence on tyrosine kinases rather than GTP-binding proteins.	Staurosporine	157-170	CD53 molecule	Homo sapiens	87-91
8344313-7	1993	The protein kinase inhibitor staurosporine inhibited PLD activation by PDGF or TPA with almost identical dose/response curves.	Staurosporine	29-42	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	53-56
8344313-8	1993	In contrast, staurosporine potentiated prostaglandin-F2 alpha-induced PLD activation.	Staurosporine	13-26	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	70-73
7694083-2	1993	Treatment of Y1 cells with either staurosporine or calphostin C, inhibitors of PKC, increases steroid hormone production up to 7-fold.	Staurosporine	34-47	proline rich transmembrane protein 2	Homo sapiens	79-82
7694083-4	1993	Staurosporine increases expression of a transiently transfected SCC promoter--human growth hormone construct in Y1 cells, indicating that PKC regulates expression of SCC mRNA at the level of transcription.	Staurosporine	0-13	growth hormone 1	Homo sapiens	84-98
7694083-4	1993	Staurosporine increases expression of a transiently transfected SCC promoter--human growth hormone construct in Y1 cells, indicating that PKC regulates expression of SCC mRNA at the level of transcription.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	138-141
7687570-4	1993	Using the fusion protein, we also revealed that staurosporin, a well-known kinase inhibitor, directly affects autophosphorylation of the C-terminal half of the c-src protein.	Staurosporine	48-60	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	160-165
8393449-14	1993	In contrast, staurosporine (100 nM), H7 (15 microM), or chronic treatment with PMA for 20 h to down-regulate protein kinase C completely prevented the increase in LPC in response to thrombin.	Staurosporine	13-26	coagulation factor II, thrombin	Homo sapiens	182-190
8224521-6	1993	Treating the down-regulated cultures with staurosporine, secretion of ANP was still significantly reduced.	Staurosporine	42-55	natriuretic peptide A	Rattus norvegicus	70-73
8224521-7	1993	The present results suggest that the decreased ANP secretion and the translocation of ANP-containing specific granules in the atrial myocytes following treatment with staurosporine or H7, is mediated through mechanisms not, or only partly, requiring PKC.	Staurosporine	167-180	natriuretic peptide A	Rattus norvegicus	47-50
8224521-7	1993	The present results suggest that the decreased ANP secretion and the translocation of ANP-containing specific granules in the atrial myocytes following treatment with staurosporine or H7, is mediated through mechanisms not, or only partly, requiring PKC.	Staurosporine	167-180	natriuretic peptide A	Rattus norvegicus	86-89
8224525-12	1993	In contrast, the Ca(2+)-dependent PKC activity in anterior pituitary was inhibited by H7, staurosporine and Ro-31-8220 with high potency as in all other preparations.	Staurosporine	90-103	protein kinase C, alpha	Rattus norvegicus	34-37
8392335-5	1993	The possibility that dystrophin could be phosphorylated by protein kinase C is suggested by the inhibition of phosphorylation by staurosporin.	Staurosporine	129-141	dystrophin	Homo sapiens	21-31
7686500-5	1993	The "metachromatic" ML-1 cells were positive for CD14, indicating that staurosporine induced the differentiation of ML-1 cells into metachromatic monocytes/macrophages, 1 alpha,25-dihydroxyvitamin D3 (VD3) enhanced appearance of metachromatic granules in staurosporine-treated cells.	Staurosporine	71-84	CD14 molecule	Homo sapiens	49-53
8325335-6	1993	TNF-alpha secretion in response to both Nocardia fractions was inhibited by sphingosine, staurosporine and calphostin C, known PKC inhibitors, as well as by a PKC depletion procedure.	Staurosporine	89-102	tumor necrosis factor	Homo sapiens	0-9
8374745-5	1993	The GGF-induced proliferation of Schwann cells was significantly inhibited by staurosporine, a PKC inhibitor, in a dose-dependent manner, while H-8, a specific inhibitor for cyclic nucleotide-dependent protein kinases, did not show an inhibitory effect even at a high concentration.	Staurosporine	78-91	neuregulin 1	Homo sapiens	4-7
8374745-5	1993	The GGF-induced proliferation of Schwann cells was significantly inhibited by staurosporine, a PKC inhibitor, in a dose-dependent manner, while H-8, a specific inhibitor for cyclic nucleotide-dependent protein kinases, did not show an inhibitory effect even at a high concentration.	Staurosporine	78-91	proline rich transmembrane protein 2	Homo sapiens	95-98
8326129-9	1993	H7 and staurosporine also blocked IL-1 and PGE2 stimulated increases in IL-1R mRNA.	Staurosporine	7-20	interleukin 1 receptor type 1	Homo sapiens	72-77
7686753-2	1993	Induction of E-selectin and VCAM-1 expression by dPPA was completely inhibited by the PKC inhibitors staurosporine and Ro31-7549.	Staurosporine	101-114	selectin E	Homo sapiens	13-23
7686753-2	1993	Induction of E-selectin and VCAM-1 expression by dPPA was completely inhibited by the PKC inhibitors staurosporine and Ro31-7549.	Staurosporine	101-114	vascular cell adhesion molecule 1	Homo sapiens	28-34
8391006-3	1993	Priming was not altered by pertussis toxin or intracellular calcium chelation, but the PAF receptor antagonist WEB 2086 and the protein kinase C (PKC) inhibitors sphinganine and staurosporine significantly inhibited the primed response.	Staurosporine	178-191	PCNA clamp associated factor	Homo sapiens	87-90
8392097-5	1993	Increased IPn and cytidine diphosphate-diacylglycerol accumulation preceded the onset of cell killing by approximately 1 h. TNF-mediated cytotoxicity and TNF-induced IPn accumulation were equally sensitive to inhibition by the phospholipase inhibitor neomycin and to stimulation by the protein kinase inhibitor staurosporine.	Staurosporine	311-324	tumor necrosis factor	Mus musculus	124-127
8392097-5	1993	Increased IPn and cytidine diphosphate-diacylglycerol accumulation preceded the onset of cell killing by approximately 1 h. TNF-mediated cytotoxicity and TNF-induced IPn accumulation were equally sensitive to inhibition by the phospholipase inhibitor neomycin and to stimulation by the protein kinase inhibitor staurosporine.	Staurosporine	311-324	tumor necrosis factor	Mus musculus	154-157
8515268-0	1993	K-252a and staurosporine promote choline acetyltransferase activity in rat spinal cord cultures.	Staurosporine	11-24	choline O-acetyltransferase	Rattus norvegicus	33-58
8355467-4	1993	Concurrent incubation with 0.05 microM of the PKC inhibitor staurosporine blocked both MARCKS protein phosphorylation and the decrease in TX receptor sites in response to either PDBu or 30 mM glucose.	Staurosporine	60-73	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	87-93
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 beta	Homo sapiens	71-80
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	103-113
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 alpha	Homo sapiens	181-191
8234146-6	1993	A protein kinase C (PKC) inhibitor, staurosporine, also suppressed the IL-1 beta production induced by IL-1 alpha or PMA, suggesting that the PKC pathway plays an important role in IL-1 alpha-induced IL-1 beta production.	Staurosporine	36-49	interleukin 1 beta	Homo sapiens	200-209
8391810-2	1993	Evidence is also presented that staurosporine not only did not inhibit, but amplified the potentiation of phagocytosis by PMA and TNF-alpha.	Staurosporine	32-45	tumor necrosis factor	Homo sapiens	130-139
8391255-0	1993	Protein kinase C activity is not involved in N-formylmethionyl-leucyl-phenylalanine-induced phospholipase D activation in human neutrophils, but is essential for concomitant NADPH oxidase activation: studies with a staurosporine analogue with improved selectivity for protein kinase C.	Staurosporine	215-228	proline rich transmembrane protein 2	Homo sapiens	0-16
8391255-9	1993	Activation of PLD by fMLP was enhanced in the presence of staurosporine, but not in the presence of cgp41251.	Staurosporine	58-71	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-17
8391255-9	1993	Activation of PLD by fMLP was enhanced in the presence of staurosporine, but not in the presence of cgp41251.	Staurosporine	58-71	formyl peptide receptor 1	Homo sapiens	21-25
8391255-11	1993	Both staurosporine and H-89 reversed the dibutyryl-cyclic-AMP-induced inhibition of PLD activation, whereas cgp41251 was without effect.	Staurosporine	5-18	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	84-87
8391255-12	1993	These results indicate that the potentiating effect of staurosporine on PLD activation induced by fMLP does not reflect a feedback inhibition by PKC activation, but instead a feedback inhibition by PKC activation.	Staurosporine	55-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	72-75
8391255-12	1993	These results indicate that the potentiating effect of staurosporine on PLD activation induced by fMLP does not reflect a feedback inhibition by PKC activation, but instead a feedback inhibition by PKC activation.	Staurosporine	55-68	formyl peptide receptor 1	Homo sapiens	98-102
8391255-12	1993	These results indicate that the potentiating effect of staurosporine on PLD activation induced by fMLP does not reflect a feedback inhibition by PKC activation, but instead a feedback inhibition by PKC activation.	Staurosporine	55-68	proline rich transmembrane protein 2	Homo sapiens	145-148
8391255-12	1993	These results indicate that the potentiating effect of staurosporine on PLD activation induced by fMLP does not reflect a feedback inhibition by PKC activation, but instead a feedback inhibition by PKC activation.	Staurosporine	55-68	proline rich transmembrane protein 2	Homo sapiens	198-201
8103344-4	1993	While staurosporine, H7 and sphingosine, three known PKC inhibitors, blocked the PMA effect, only staurosporine abrogated the action of IFN-gamma.	Staurosporine	98-111	interferon gamma	Homo sapiens	136-145
8394261-5	1993	Staurosporine, a potent PKC inhibitor, significantly reduced the enzyme activity.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	24-27
8504157-8	1993	The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine.	Staurosporine	74-87	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	177-180
8389617-13	1993	LXA4-induced phospholipase D (PLD) activation gave a biphasic concentration-dependent response comprised of at least two components: one phase being islet-activating protein (IAP)-sensitive (LXA4 10(-9) mol/L peak activity) and the other was staurosporine-sensitive (LXA4 10(-7) mol/L peak activity).	Staurosporine	242-255	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	13-28
8389617-13	1993	LXA4-induced phospholipase D (PLD) activation gave a biphasic concentration-dependent response comprised of at least two components: one phase being islet-activating protein (IAP)-sensitive (LXA4 10(-9) mol/L peak activity) and the other was staurosporine-sensitive (LXA4 10(-7) mol/L peak activity).	Staurosporine	242-255	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	30-33
8395923-4	1993	3) The induction of VGF protein by NGF was blocked by staurosporine, but its induction by bFGF was not.	Staurosporine	54-67	VGF nerve growth factor inducible	Rattus norvegicus	20-23
8395923-5	1993	These findings suggest that the induction of VGF by NGF is distinct from that by bFGF in terms of sensitivities to MTA and staurosporine.	Staurosporine	123-136	nerve growth factor	Rattus norvegicus	52-55
8395923-4	1993	3) The induction of VGF protein by NGF was blocked by staurosporine, but its induction by bFGF was not.	Staurosporine	54-67	nerve growth factor	Rattus norvegicus	35-38
8495426-0	1993	Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.	Staurosporine	93-106	tumor necrosis factor	Mus musculus	32-53
8099849-6	1993	When activated through the TCR/CD3 pathway, the CD2 pathway, or directly by the phorbol ester, PMA, the memory (CD26+) T cells showed an increased proliferative response that was inhibited by the pkC inhibitor, staurosporine.	Staurosporine	211-224	CD2 molecule	Homo sapiens	48-51
8099849-6	1993	When activated through the TCR/CD3 pathway, the CD2 pathway, or directly by the phorbol ester, PMA, the memory (CD26+) T cells showed an increased proliferative response that was inhibited by the pkC inhibitor, staurosporine.	Staurosporine	211-224	dipeptidyl peptidase 4	Homo sapiens	112-116
8495426-3	1993	In this study, we report that the protein kinase inhibitor staurosporine (56 to 1500 nM) increases about 500 times the in vitro cytotoxic activity of TNF for several murine and human tumor cell lines.	Staurosporine	59-72	tumor necrosis factor	Mus musculus	150-153
8495426-4	1993	Even some tumor cell lines which are resistant to TNF cytotoxicity could be sensitized to TNF killing by staurosporine.	Staurosporine	105-118	tumor necrosis factor	Mus musculus	50-53
8495426-4	1993	Even some tumor cell lines which are resistant to TNF cytotoxicity could be sensitized to TNF killing by staurosporine.	Staurosporine	105-118	tumor necrosis factor	Mus musculus	90-93
8495426-5	1993	In the L929 fibrosarcoma cell line, staurosporine also enhanced the transcriptional activation of interleukin 6 synthesis by TNF (500-fold stimulation at 56 nM).	Staurosporine	36-49	tumor necrosis factor	Mus musculus	125-128
8495426-6	1993	At the biochemical level, staurosporine increased the TNF-mediated activation of phospholipases C and D and the transcription factor NF-kappa B in L929 cells.	Staurosporine	26-39	tumor necrosis factor	Mus musculus	54-57
8495426-6	1993	At the biochemical level, staurosporine increased the TNF-mediated activation of phospholipases C and D and the transcription factor NF-kappa B in L929 cells.	Staurosporine	26-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	133-143
8495426-7	1993	The TNF-sensitizing effect of staurosporine does not seem to be mediated by one of the currently known staurosporine-sensitive kinases, as various other inhibitors which also inhibit one or more of these kinases were not synergistic with TNF.	Staurosporine	30-43	tumor necrosis factor	Mus musculus	4-7
8495426-8	1993	Interestingly, staurosporine (1 microgram) also enhanced the in vivo antitumor activity of TNF against a murine tumor model (L929 fibrosarcoma) in athymic nude mice (Swiss-nu/nu; s.c. treatment).	Staurosporine	15-28	tumor necrosis factor	Mus musculus	91-94
8495426-9	1993	These results suggest that TNF responsiveness of tumor cells is regulated by a novel staurosporine-sensitive target and that the combination of TNF and staurosporine may open new strategies of tumor treatment.	Staurosporine	85-98	tumor necrosis factor	Mus musculus	27-30
8495426-9	1993	These results suggest that TNF responsiveness of tumor cells is regulated by a novel staurosporine-sensitive target and that the combination of TNF and staurosporine may open new strategies of tumor treatment.	Staurosporine	85-98	tumor necrosis factor	Mus musculus	144-147
8501977-6	1993	Furthermore, we report that both H-7 and staurosporine present similar inhibitory effects on proliferation (PE1) as on self-renewal (PEs) of AML-CFU.	Staurosporine	41-54	ETS variant transcription factor 3	Homo sapiens	108-111
8396623-5	1993	Staurosporine, a PKC inhibitor, abolished the inhibitory effects of TPA and induced accumulation of IGF-II mRNA.	Staurosporine	0-13	insulin like growth factor 2	Homo sapiens	100-106
7683925-3	1993	The PKC inhibitors (H-7, staurosporine, and calphostin C), but not HA-1004, inhibited TNF-induced uPA expression, synthesis, and secretion in a dose-dependent manner.	Staurosporine	25-38	proline rich transmembrane protein 2	Homo sapiens	4-7
7684371-8	1993	Furthermore, CCK-induced secretion was not affected by relatively specific protein kinase C inhibition by H-7, but was decreased by staurosporine, an inhibitor of both protein kinase C and tyrosine kinase activities in these cells.	Staurosporine	132-145	cholecystokinin	Homo sapiens	13-16
8387431-0	1993	Anti-CD9 monoclonal antibody elicits staurosporine inhibitable phosphatidylinositol 4,5-bisphosphate hydrolysis, phosphatidylinositol 3,4-bisphosphate synthesis, and protein-tyrosine phosphorylation in human platelets.	Staurosporine	37-50	CD9 molecule	Homo sapiens	5-8
7683925-3	1993	The PKC inhibitors (H-7, staurosporine, and calphostin C), but not HA-1004, inhibited TNF-induced uPA expression, synthesis, and secretion in a dose-dependent manner.	Staurosporine	25-38	tumor necrosis factor	Homo sapiens	86-89
7683925-3	1993	The PKC inhibitors (H-7, staurosporine, and calphostin C), but not HA-1004, inhibited TNF-induced uPA expression, synthesis, and secretion in a dose-dependent manner.	Staurosporine	25-38	plasminogen activator, urokinase	Homo sapiens	98-101
7506863-4	1993	We did not observe statistically significant effects of selective PKC inhibitors on exocytosis induced by the peptide formylmeth-leu-phe (FMLP) or the ionophore A23187, whereas staurosporine potentiated the FMLP-induced histamine release in a dose-dependent fashion: maximum potentiation was 63.5 +/- 8.9% vs. control at 1 mumol/l (n = 4).	Staurosporine	177-190	formyl peptide receptor 1	Homo sapiens	207-211
8499486-6	1993	Staurosporine, an inhibitor of protein kinase C activity, suppressed the TPA-induction of gelatinase activity.	Staurosporine	0-13	plasminogen activator, tissue type	Homo sapiens	73-76
8489251-7	1993	Insulin- and TPA-stimulated 2-[3H]DOG uptake was inhibited by a protein kinase inhibitor, staurosporine.	Staurosporine	90-103	insulin	Canis lupus familiaris	0-7
7683590-0	1993	Inhibition by glucocorticoid and staurosporine of IL-4-dependent CD23 production in B lymphocytes is reversed on engaging CD40.	Staurosporine	33-46	interleukin 4	Homo sapiens	50-54
7688546-6	1993	H7 and staurosporine dose-dependently inhibited the phosphorylation of MBP, induced by DOG and calcium in the presence of okadaic acid.	Staurosporine	7-20	myelin basic protein	Canis lupus familiaris	71-74
7683590-0	1993	Inhibition by glucocorticoid and staurosporine of IL-4-dependent CD23 production in B lymphocytes is reversed on engaging CD40.	Staurosporine	33-46	Fc epsilon receptor II	Homo sapiens	65-69
7683590-0	1993	Inhibition by glucocorticoid and staurosporine of IL-4-dependent CD23 production in B lymphocytes is reversed on engaging CD40.	Staurosporine	33-46	CD40 molecule	Homo sapiens	122-126
7683590-3	1993	We now report that occupancy of CD40 relieves potent suppression of IL-4-induced CD23 production by glucocorticoid or the relatively broad-acting kinase inhibitor staurosporine.	Staurosporine	163-176	CD40 molecule	Homo sapiens	32-36
7683590-3	1993	We now report that occupancy of CD40 relieves potent suppression of IL-4-induced CD23 production by glucocorticoid or the relatively broad-acting kinase inhibitor staurosporine.	Staurosporine	163-176	interleukin 4	Homo sapiens	68-72
7683590-3	1993	We now report that occupancy of CD40 relieves potent suppression of IL-4-induced CD23 production by glucocorticoid or the relatively broad-acting kinase inhibitor staurosporine.	Staurosporine	163-176	Fc epsilon receptor II	Homo sapiens	81-85
7683590-4	1993	Interruption of the IL-4 signal was observed with concentrations of staurosporine considered to be selective for protein kinase C (PKC) inhibition (IC50 = 10 nM) but not with genistein or tyrphostins, effective inhibitors of tyrosine kinase activity.	Staurosporine	68-81	interleukin 4	Homo sapiens	20-24
7683590-5	1993	On ligation of CD40, staurosporine no longer inhibited the IL-4 signal: at concentrations of between 1 and 20 nM, staurosporine actually increased by as much as 100% the rate of CD23 production stimulated on simultaneous activation through CD40 and IL-4R.	Staurosporine	21-34	Fc epsilon receptor II	Homo sapiens	178-182
7683590-5	1993	On ligation of CD40, staurosporine no longer inhibited the IL-4 signal: at concentrations of between 1 and 20 nM, staurosporine actually increased by as much as 100% the rate of CD23 production stimulated on simultaneous activation through CD40 and IL-4R.	Staurosporine	114-127	interleukin 4	Homo sapiens	59-63
7683590-5	1993	On ligation of CD40, staurosporine no longer inhibited the IL-4 signal: at concentrations of between 1 and 20 nM, staurosporine actually increased by as much as 100% the rate of CD23 production stimulated on simultaneous activation through CD40 and IL-4R.	Staurosporine	114-127	Fc epsilon receptor II	Homo sapiens	178-182
7683590-5	1993	On ligation of CD40, staurosporine no longer inhibited the IL-4 signal: at concentrations of between 1 and 20 nM, staurosporine actually increased by as much as 100% the rate of CD23 production stimulated on simultaneous activation through CD40 and IL-4R.	Staurosporine	114-127	CD40 molecule	Homo sapiens	240-244
7683590-5	1993	On ligation of CD40, staurosporine no longer inhibited the IL-4 signal: at concentrations of between 1 and 20 nM, staurosporine actually increased by as much as 100% the rate of CD23 production stimulated on simultaneous activation through CD40 and IL-4R.	Staurosporine	114-127	interleukin 4 receptor	Homo sapiens	249-254
7683590-8	1993	Activation through CD40 left inhibition of phorbol ester-induced CD23 expression by staurosporine, RO-31-8220, or glucocorticoid unchecked.	Staurosporine	84-97	CD40 molecule	Homo sapiens	19-23
7683590-8	1993	Activation through CD40 left inhibition of phorbol ester-induced CD23 expression by staurosporine, RO-31-8220, or glucocorticoid unchecked.	Staurosporine	84-97	Fc epsilon receptor II	Homo sapiens	65-69
8477800-6	1993	The treatment with the PKC inhibitor staurosporine abolished the induction of CD69 induced by PMA or K562.	Staurosporine	37-50	CD69 molecule	Homo sapiens	78-82
8482723-10	1993	Staurosporine inhibited both basal and a TPA-induced phosphorylation of an endogenous 80kDa PKC substrate (p80), and also blocked c-fos proto-oncogene mRNA expression induced by the phorbol ester.	Staurosporine	0-13	coilin	Homo sapiens	107-110
8321621-5	1993	The inhibitory effect of 4 beta-PDB on GCl was prevented by pretreatment of the muscle preparation with the PKC inhibitor staurosporine.	Staurosporine	122-135	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	39-42
8471626-4	1993	GM-CSF also induced the NBT-reducing activity of the cells in combination with 2,5-dihydroxycinnamic acid methyl ester, psi-tectorigenin and staurosporine, although each of them did not induce the activity.	Staurosporine	141-154	colony stimulating factor 2	Homo sapiens	0-6
8484776-3	1993	The TPA-induced monocyte chemotactic protein-1 expression was abolished by treating the cells with both staurosporine and genistein; however, only a portion of the LPS-induced expression was inhibited by staurosporine/genistein.	Staurosporine	104-117	C-C motif chemokine ligand 2	Homo sapiens	16-46
8387271-3	1993	PKC-dependent AMP deaminase phosphorylation was rapid, linear with respect to time and the concentrations of PKC and AMP deaminase in the reaction, and inhibitable by staurosporine.	Staurosporine	167-180	proline rich transmembrane protein 2	Homo sapiens	0-3
8387271-3	1993	PKC-dependent AMP deaminase phosphorylation was rapid, linear with respect to time and the concentrations of PKC and AMP deaminase in the reaction, and inhibitable by staurosporine.	Staurosporine	167-180	proline rich transmembrane protein 2	Homo sapiens	109-112
8384448-6	1993	Staurosporine (25 nM) did not inhibit ADP-induced aggregation, although it strongly inhibited thrombin-induced aggregation and release of [14C]5-hydroxytryptamine.	Staurosporine	0-13	coagulation factor II, thrombin	Homo sapiens	94-102
8484020-5	1993	The response to GLP-1 (10 nM) in the presence of 8 mM glucose is abolished by the metabolic inhibitor mannoheptulose (15 mM), and reduced by the calcium channel antagonist nitrendipine (5 microM), or the protein kinase C inhibitor of staurosporine (20 nM).	Staurosporine	234-247	glucagon	Rattus norvegicus	16-21
8454619-5	1993	Staurosporine and K-252a were less effective by more than 2 and 1 orders of magnitude, respectively, in inhibiting insulin receptor-catalyzed PolyGlu4Tyr phosphorylation in cell-free experiments.	Staurosporine	0-13	insulin receptor	Rattus norvegicus	115-131
8443799-0	1993	Persistent inhibition of DNA synthesis in irradiated rat embryo fibroblasts expressing the oncogenes H-ras plus v-myc derives from inhibition of replicon initiation and is mitigated by staurosporine.	Staurosporine	185-198	HRas proto-oncogene, GTPase	Rattus norvegicus	101-106
8443799-2	1993	Here we show that this enhanced inhibition of DNA replication in cells expressing H-ras plus v-myc is due to inhibition of the main controlling event of DNA replication, i.e., replicon initiation, that this inhibition is reversible, and that the expression of this phenotype is reverted by staurosporine, a protein kinase inhibitor.	Staurosporine	290-303	HRas proto-oncogene, GTPase	Rattus norvegicus	82-87
8385106-7	1993	Staurosporine, herbimycin A, and tyrphostin were identified as inhibitors of the GH receptor-associated kinase.	Staurosporine	0-13	growth hormone receptor	Homo sapiens	81-92
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	Staurosporine	69-82	interleukin 1 beta	Homo sapiens	134-138
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	Staurosporine	69-82	tumor necrosis factor	Homo sapiens	147-150
7681061-7	1993	This hypothesis was confirmed by experiments with the PKC inhibitors staurosporine and calphostin C, which prevented the induction of IL-1 mRNA by TNF and accelerated the decay of this mRNA in cells pretreated with TNF.	Staurosporine	69-82	tumor necrosis factor	Homo sapiens	215-218
8454047-5	1993	The inclusion of 5 microM staurosporine for 10 min diminished the production of [3H]PEt and [14C]PEt by 27% and 53% in VP-treated cells, and by 100% and 75% in TPA-treated cells, respectively.	Staurosporine	26-39	arginine vasopressin	Rattus norvegicus	119-121
8452537-5	1993	Confirming this, 4 beta-phorbol 12-monoacetate and 4 alpha-phorbol had no effect on cellular eicosanoid formation, while the PMA-induced response was fully abolished both in the presence of the PKC inhibitors staurosporine and CGP 41251 and in PKC-down-regulated cells.	Staurosporine	209-222	protein kinase C, alpha	Rattus norvegicus	194-197
8384125-3	1993	Protein kinase C (PKC) is known to couple membrane activity to AChR gene inactivation; myogenin gene transcription was also rapidly blocked by the PKC activator PMA, whereas electrostimulation remained without effect on myogenin gene activity in muscle that was either exposed to the kinase inhibitor staurosporine or chronically treated with PMA to deplete PKC.	Staurosporine	301-314	myogenin	Gallus gallus	87-95
8477816-5	1993	Pretreatment of mesangial cells with the PKC inhibitors staurosporine and K252a potently augmented inositol trisphosphate and 1,2-diacylglycerol formation as well as Ca2+ mobilization in response to angiotensin II.	Staurosporine	56-69	protein kinase C alpha	Homo sapiens	41-44
8477816-5	1993	Pretreatment of mesangial cells with the PKC inhibitors staurosporine and K252a potently augmented inositol trisphosphate and 1,2-diacylglycerol formation as well as Ca2+ mobilization in response to angiotensin II.	Staurosporine	56-69	angiotensinogen	Homo sapiens	199-213
7680616-5	1993	Staurosporine reversed both the phorbol ester- and the CD20-induced down-regulation.	Staurosporine	0-13	keratin 20	Homo sapiens	55-59
8318816-4	1993	TGF-beta 1-induced IANK cell chemotaxis was inhibited by protein kinase C inhibitors, such as staurosporine and H7.	Staurosporine	94-107	transforming growth factor beta 1	Homo sapiens	0-10
8095965-5	1993	Staurosporine and K252a, inhibitors of protein kinase C, decreased PMA-induced ECP secretion.	Staurosporine	0-13	ribonuclease A family member 3	Homo sapiens	79-82
8436973-8	1993	Incubation of astrocytes with PRL in the presence of the PKC inhibitors staurosporine, 1-(-5-isoquinolinesulfonyl)-2-methylpiperazine, or polymyxin B blocked the PRL-induced increase in cell number with IC50 values of approximately 2 nM, 10 microM, and 6 microM, respectively.	Staurosporine	72-85	prolactin	Homo sapiens	30-33
8436973-8	1993	Incubation of astrocytes with PRL in the presence of the PKC inhibitors staurosporine, 1-(-5-isoquinolinesulfonyl)-2-methylpiperazine, or polymyxin B blocked the PRL-induced increase in cell number with IC50 values of approximately 2 nM, 10 microM, and 6 microM, respectively.	Staurosporine	72-85	prolactin	Homo sapiens	162-165
8384279-8	1993	Staurosporine inhibited the effect of TPA as well as of 1-84 PTH on [Ca2+]i of the islets.	Staurosporine	0-13	parathyroid hormone	Rattus norvegicus	61-64
8455768-6	1993	Inhibition of PKC activity by prolonged treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or staurosporine, a potent PKC inhibitor, before irradiation enhanced radiation-induced DNA damage and attenuated the repair of damaged DNA.	Staurosporine	101-114	protein kinase C, gamma	Rattus norvegicus	14-17
8455768-6	1993	Inhibition of PKC activity by prolonged treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) or staurosporine, a potent PKC inhibitor, before irradiation enhanced radiation-induced DNA damage and attenuated the repair of damaged DNA.	Staurosporine	101-114	protein kinase C, gamma	Rattus norvegicus	125-128
8440709-10	1993	Evidence is presented that the 80-kDa IL-6 receptor up-regulation by PMA-dexamethasone is caused by the depletion of protein kinase C since the protein kinase C inhibitor staurosporine mimics the effect of PMA-dexamethasone.	Staurosporine	171-184	interleukin 6	Homo sapiens	38-42
8094032-10	1993	These results suggest that although PMA-induced ICAM-1 expression is PKC dependent on HS 683 and SK-N-SH cells, the stimulation of ICAM-1 expression by retinoic acid and by IFN-gamma may be due to PKC inactivation at longer time points (24 h), as mimicked by 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, staurosporine, or PKC depletion by high doses of PMA.	Staurosporine	322-335	interferon gamma	Homo sapiens	173-182
8429027-3	1993	Shear-induced p47 phosphorylation depends entirely on vWF binding to platelet glycoprotein (Gp) Ib and GpIIb-IIIa, and the specific inhibition of protein kinase C with the staurosporine analogue Ro 31-7549 inhibits the full aggregation response to shear.	Staurosporine	172-185	pleckstrin	Homo sapiens	14-17
8439286-9	1993	(5) Phosphorylation of p47phox and p67phox can be quantitatively dissociated from translocation, as staurosporine markedly inhibits phosphorylation but not translocation.	Staurosporine	100-113	neutrophil cytosolic factor 1	Homo sapiens	23-30
8439286-9	1993	(5) Phosphorylation of p47phox and p67phox can be quantitatively dissociated from translocation, as staurosporine markedly inhibits phosphorylation but not translocation.	Staurosporine	100-113	neutrophil cytosolic factor 2	Homo sapiens	35-42
8435068-1	1993	Staurosporine, a potent protein kinase C (PKC) inhibitor, was studied for its effects on the binding of phorbol 12,13-dibutyrate (PDBu) to human polymorphonuclear leucocytes (PMNs).	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	24-40
8435068-1	1993	Staurosporine, a potent protein kinase C (PKC) inhibitor, was studied for its effects on the binding of phorbol 12,13-dibutyrate (PDBu) to human polymorphonuclear leucocytes (PMNs).	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	42-45
8457474-5	1993	Both findings could be completely inhibited in the presence of staurosporine, a potent inhibitor of protein kinase C (PK-C).	Staurosporine	63-76	proline rich transmembrane protein 2	Homo sapiens	100-116
8457474-5	1993	Both findings could be completely inhibited in the presence of staurosporine, a potent inhibitor of protein kinase C (PK-C).	Staurosporine	63-76	proline rich transmembrane protein 2	Homo sapiens	118-122
8433044-8	1993	In contrast, bradykinin- or ATP-induced phosphorus 32-labeled PA and [32P]-labeled PEt formation was only partially blocked (70% inhibition) by either staurosporine (10 mumol/L) or PKC down-regulation, suggesting that part of agonist-stimulated PLD activity may occur in the absence of PKC activation.	Staurosporine	151-164	kininogen 1	Bos taurus	13-23
7678628-6	1993	The elevated adhesion was decreased with monocytes were preincubated with staurosporine, an inhibitor of intracellular protein kinase activity and was markedly inhibited by mAb against the common beta 2-subunit (CD18) of the CD11/CD18 molecules on monocytes and by mAb against ICAM-1 on 24-h rIL-1 alpha-stimulated venous EC.	Staurosporine	74-87	integrin subunit beta 2	Homo sapiens	212-216
7678628-6	1993	The elevated adhesion was decreased with monocytes were preincubated with staurosporine, an inhibitor of intracellular protein kinase activity and was markedly inhibited by mAb against the common beta 2-subunit (CD18) of the CD11/CD18 molecules on monocytes and by mAb against ICAM-1 on 24-h rIL-1 alpha-stimulated venous EC.	Staurosporine	74-87	integrin subunit beta 2	Homo sapiens	230-234
7678628-6	1993	The elevated adhesion was decreased with monocytes were preincubated with staurosporine, an inhibitor of intracellular protein kinase activity and was markedly inhibited by mAb against the common beta 2-subunit (CD18) of the CD11/CD18 molecules on monocytes and by mAb against ICAM-1 on 24-h rIL-1 alpha-stimulated venous EC.	Staurosporine	74-87	intercellular adhesion molecule 1	Homo sapiens	277-283
7678628-6	1993	The elevated adhesion was decreased with monocytes were preincubated with staurosporine, an inhibitor of intracellular protein kinase activity and was markedly inhibited by mAb against the common beta 2-subunit (CD18) of the CD11/CD18 molecules on monocytes and by mAb against ICAM-1 on 24-h rIL-1 alpha-stimulated venous EC.	Staurosporine	74-87	interleukin 1 alpha	Rattus norvegicus	292-303
8381283-0	1993	Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.	Staurosporine	146-159	C-X-C motif chemokine ligand 8	Homo sapiens	40-53
8381280-2	1993	Dibutyryl-cAMP, forskolin, staurosporine and phorbol 12-myristate 13-acetate were all found to mimic the cytostatic action of IL-1 on K562 cells.	Staurosporine	27-40	interleukin 1 alpha	Homo sapiens	126-130
8093679-0	1993	Staurosporine reduces P-glycoprotein expression and modulates multidrug resistance.	Staurosporine	0-13	ATP binding cassette subfamily B member 1	Homo sapiens	22-36
8093679-1	1993	We have investigated the effect of staurosporine and other kinase inhibitors on the mRNA and protein levels of the P-glycoprotein (P-gp) in multidrug resistant (MDR) cells.	Staurosporine	35-48	ATP binding cassette subfamily B member 1	Homo sapiens	115-129
8093679-1	1993	We have investigated the effect of staurosporine and other kinase inhibitors on the mRNA and protein levels of the P-glycoprotein (P-gp) in multidrug resistant (MDR) cells.	Staurosporine	35-48	ATP binding cassette subfamily B member 1	Homo sapiens	131-135
8093679-2	1993	Treatment of human MDR KB-V1 cells with staurosporine for 24 h caused up to a 50% decrease in the amount of P-gp mRNA and protein present.	Staurosporine	40-53	ATP binding cassette subfamily B member 1	Homo sapiens	108-112
8416807-2	1993	In the presence of ethanol, staurosporine induced a production of phosphatidylethanol (PEt) reaching, 250% of control values, and partial inhibition of PA production, consistent with PLD activation.	Staurosporine	28-41	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	183-186
8416807-4	1993	Staurosporine concentrations that induced an elevation in PA completely depressed protein kinase C (PKC) activity in both soluble and particulate cell fractions, suggesting that PLD activation may occur independently from PKC activation.	Staurosporine	0-13	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	178-181
8416807-5	1993	PLD may thus represent a potential cellular target for staurosporine action.	Staurosporine	55-68	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	0-3
8273591-3	1993	Staurosporine, a potent but non-specific inhibitor of protein kinases, inhibited PMA-induced (IC50 2 nM) but not IL-1 beta or TNF alpha (IC50 &gt; 200 nM) induced IL-8 production.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	163-167
8273591-6	1993	Northern blot analysis of IL-8 mRNA revealed that staurosporine suppressed mRNA increase following stimulation by PMA but not by IL-1.	Staurosporine	50-63	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
8480534-6	1993	A new generation of bis-indolylmaleimides, derived from the lead provided by staurosporine, shows a high degree of selectivity for PKC over closely related protein kinases and such agents may provide more appropriate tools to investigate the role of PKC in cellular processes.	Staurosporine	77-90	proline rich transmembrane protein 2	Homo sapiens	131-134
8480534-6	1993	A new generation of bis-indolylmaleimides, derived from the lead provided by staurosporine, shows a high degree of selectivity for PKC over closely related protein kinases and such agents may provide more appropriate tools to investigate the role of PKC in cellular processes.	Staurosporine	77-90	proline rich transmembrane protein 2	Homo sapiens	250-253
8381283-0	1993	Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.	Staurosporine	146-159	interferon gamma	Homo sapiens	85-94
8381283-0	1993	Studies on the regulatory mechanisms of interleukin-8 gene expression in resting and IFN-gamma-treated neutrophils: evidence on the capability of staurosporine of inducing the production of interleukin-8 by human neutrophils.	Staurosporine	146-159	C-X-C motif chemokine ligand 8	Homo sapiens	190-203
8424766-4	1993	As myosin light chain is a substrate for both myosin light-chain kinase and protein kinase C, these results suggest that Ro 31-8220 is inhibiting only the protein kinase C-induced phosphorylation and that Ro 31-8220 has a greater selectivity to protein kinase C than does its structural analogue staurosporine.	Staurosporine	296-309	myosin heavy chain 14	Homo sapiens	3-9
8381050-8	1993	An increase in membrane-associated protein kinase C (PK-C) activity was detected after the addition of the growth factor and the mitogenic effect of LMW-BCGF was partially suppressed when B cell blasts were incubated with staurosporine or H-3, two inhibitors of PK-C activity.	Staurosporine	222-235	proline rich transmembrane protein 2	Homo sapiens	262-266
8388775-10	1993	This effect was abolished by the PKC inhibitor staurosporine (5 nM), by overnight (12-24 hours) exposure to 0.2 microM phorbol esters and by the perfusion with 10 microM ethylisopropylamiloride (EIPA), a Na+/H+ exchange inhibitor.	Staurosporine	47-60	protein kinase C, gamma	Rattus norvegicus	33-36
8381608-4	1993	Staurosporine (STPN) completely blocked the stimulation in both cases, suggesting that ET-1 release is increased via activation of protein kinase C (PKC).	Staurosporine	0-13	endothelin 1	Homo sapiens	87-91
8381608-4	1993	Staurosporine (STPN) completely blocked the stimulation in both cases, suggesting that ET-1 release is increased via activation of protein kinase C (PKC).	Staurosporine	15-19	endothelin 1	Homo sapiens	87-91
8381050-8	1993	An increase in membrane-associated protein kinase C (PK-C) activity was detected after the addition of the growth factor and the mitogenic effect of LMW-BCGF was partially suppressed when B cell blasts were incubated with staurosporine or H-3, two inhibitors of PK-C activity.	Staurosporine	222-235	proline rich transmembrane protein 2	Homo sapiens	35-51
8381050-8	1993	An increase in membrane-associated protein kinase C (PK-C) activity was detected after the addition of the growth factor and the mitogenic effect of LMW-BCGF was partially suppressed when B cell blasts were incubated with staurosporine or H-3, two inhibitors of PK-C activity.	Staurosporine	222-235	proline rich transmembrane protein 2	Homo sapiens	53-57
7694703-4	1993	The kinase inhibitor, staurosporine (0.1-100 nM), enhanced PAF-induced basophil histamine release, whereas the G-protein inhibitor, pertussis toxin (1 microgram/ml), had an inhibitory effect.	Staurosporine	22-35	PCNA clamp associated factor	Homo sapiens	59-62
8490103-6	1993	The IC50 values for the inhibition of TNF alpha production were 0.2 nM for staurosporine, and 20 nM for K252a, Calphostin C and chelerythrine.	Staurosporine	75-88	tumor necrosis factor	Homo sapiens	38-47
8417145-4	1993	The activation of protein kinase C appears as an obligatory step during these processes, because (a) inhibition of protein kinase C by staurosporine blocks the induction by endothelin or phorbol esters of both c-fos and nerve growth factor, and (b) phorbol ester-evoked down-regulation of protein kinase C completely abolishes the c-fos induction by endothelin, but not that by the beta-adrenergic agonist isoproterenol, a known activator of the cyclic AMP-dependent pathway.	Staurosporine	135-148	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	210-215
15278495-0	1993	Modification of hepatic protein kinase C with phorbol myristate acetate and staurosporine alters hemodynamics in the perfused rat liver.	Staurosporine	76-89	protein kinase C, gamma	Rattus norvegicus	24-40
15278495-7	1993	Staurosporine (St), a potent PKC inhibitor at 4 x 10(-7) M produced a small increase in hepatic flow.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	29-32
15278495-7	1993	Staurosporine (St), a potent PKC inhibitor at 4 x 10(-7) M produced a small increase in hepatic flow.	Staurosporine	0-2	protein kinase C, gamma	Rattus norvegicus	29-32
7509997-3	1993	A selective thrombin inhibitor (argatroban) and a PKC inhibitor (staurosporine) also inhibited thrombin-induced but not basal prepro-ET-1 mRNA expression.	Staurosporine	65-78	coagulation factor II, thrombin	Bos taurus	95-103
8455059-0	1993	Sensitization of C6 glioma cells to radiation by staurosporine, a potent protein kinase C inhibitor.	Staurosporine	49-62	proline rich transmembrane protein 2	Homo sapiens	73-89
8417145-4	1993	The activation of protein kinase C appears as an obligatory step during these processes, because (a) inhibition of protein kinase C by staurosporine blocks the induction by endothelin or phorbol esters of both c-fos and nerve growth factor, and (b) phorbol ester-evoked down-regulation of protein kinase C completely abolishes the c-fos induction by endothelin, but not that by the beta-adrenergic agonist isoproterenol, a known activator of the cyclic AMP-dependent pathway.	Staurosporine	135-148	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	331-336
8455059-1	1993	The effect of staurosporine, a potent protein kinase C (PKC) inhibitor, on the sensitivity to radiation has been investigated in C6 glioma cells.	Staurosporine	14-27	proline rich transmembrane protein 2	Homo sapiens	38-54
8455059-1	1993	The effect of staurosporine, a potent protein kinase C (PKC) inhibitor, on the sensitivity to radiation has been investigated in C6 glioma cells.	Staurosporine	14-27	proline rich transmembrane protein 2	Homo sapiens	56-59
1464609-6	1992	We observed the protein kinase C-dependent phosphorylation of PLA2 in permeabilized HL60 granulocytes, together with a correlation between the effects of phorbol esters and staurosporine on this reaction and on AA release.	Staurosporine	173-186	phospholipase A2 group IB	Homo sapiens	62-66
8455059-4	1993	Since the viability of C6 cells was not affected by staurosporine alone at the concentrations tested, the radiosensitizing effect of staurosporine was considered to be mediated via suppression of PKC.	Staurosporine	133-146	proline rich transmembrane protein 2	Homo sapiens	196-199
8455059-6	1993	Therefore, staurosporine-induced sensitization of C6 cells to radiation may at least in part be mediated by its inhibitory activity for PKC.	Staurosporine	11-24	proline rich transmembrane protein 2	Homo sapiens	136-139
21043600-5	1993	PMA-stimulated and NaF-stimulated [(45)Ca(2+)] uptake was inhibited in concentration-dependent manners by the PKC inhibitor, staurosporine.	Staurosporine	125-138	C-X-C motif chemokine ligand 8	Homo sapiens	19-22
8469783-4	1993	The c-fos expression following X/XOD treatment was partly reduced by a protein kinase C inhibitor, staurosporine (ST), and markedly inhibited by another protein kinase inhibitor, 2-aminopurine (2AP), while both ST and 2AP markedly reduced hsp70 expression.	Staurosporine	99-112	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
8469783-4	1993	The c-fos expression following X/XOD treatment was partly reduced by a protein kinase C inhibitor, staurosporine (ST), and markedly inhibited by another protein kinase inhibitor, 2-aminopurine (2AP), while both ST and 2AP markedly reduced hsp70 expression.	Staurosporine	114-116	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
1283969-2	1992	PDB and ET-1 caused slow-developing contractions (sustained and transient, respectively), which were reduced by the PKC inhibitor, staurosporine (1 and 10 nM).	Staurosporine	131-144	endothelin 1	Bos taurus	8-12
8450714-6	1993	Staurosporine, an inhibitor of protein kinase C, inhibited vasopressin-mediated GSH efflux.	Staurosporine	0-13	arginine vasopressin	Homo sapiens	59-70
7678355-7	1993	The TNF-alpha- and PMA-stimulated VCAM-1 expression is inhibited by the PKC and PKA inhibitor staurosporine (STS).	Staurosporine	94-107	tumor necrosis factor	Homo sapiens	4-13
7678355-7	1993	The TNF-alpha- and PMA-stimulated VCAM-1 expression is inhibited by the PKC and PKA inhibitor staurosporine (STS).	Staurosporine	94-107	vascular cell adhesion molecule 1	Homo sapiens	34-40
7678355-7	1993	The TNF-alpha- and PMA-stimulated VCAM-1 expression is inhibited by the PKC and PKA inhibitor staurosporine (STS).	Staurosporine	109-112	tumor necrosis factor	Homo sapiens	4-13
7678355-7	1993	The TNF-alpha- and PMA-stimulated VCAM-1 expression is inhibited by the PKC and PKA inhibitor staurosporine (STS).	Staurosporine	109-112	vascular cell adhesion molecule 1	Homo sapiens	34-40
1472000-8	1992	Consistent with the presence of an inhibitory component in the overall action of PKC, the PKC inhibitor staurosporine and down-regulation of PKC activity by prolonged (24 h) treatment with PMA similarly enhanced PLD activity.	Staurosporine	104-117	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	212-215
1335246-0	1992	Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites.	Staurosporine	15-28	PCNA clamp associated factor	Homo sapiens	32-58
1335246-0	1992	Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites.	Staurosporine	15-28	PCNA clamp associated factor	Homo sapiens	147-173
1335246-1	1992	Staurosporine potentiates the formation of platelet-activating factor (PAF) and causes a sustained elevation of intracellular Ca2+ ([Ca2+]i).	Staurosporine	0-13	PCNA clamp associated factor	Homo sapiens	43-69
1335246-1	1992	Staurosporine potentiates the formation of platelet-activating factor (PAF) and causes a sustained elevation of intracellular Ca2+ ([Ca2+]i).	Staurosporine	0-13	PCNA clamp associated factor	Homo sapiens	71-74
1335246-3	1992	Moreover, the PAF produced by FMLP and/or Staurosporine was completely retained in the cell.	Staurosporine	42-55	PCNA clamp associated factor	Homo sapiens	14-17
1335246-4	1992	This suggests that the effect of staurosporine in FMLP-stimulated neutrophils may be mediated by the action of endogenously produced PAF, which in turn leads to an increase in [Ca2+]i and PAF formation.	Staurosporine	33-46	formyl peptide receptor 1	Homo sapiens	50-54
1335246-4	1992	This suggests that the effect of staurosporine in FMLP-stimulated neutrophils may be mediated by the action of endogenously produced PAF, which in turn leads to an increase in [Ca2+]i and PAF formation.	Staurosporine	33-46	PCNA clamp associated factor	Homo sapiens	133-136
1460280-8	1992	Two protein kinase C (PKC) inhibitors, H7 and staurosporine, abrogate IFN-gamma/LPS- and IFN-gamma/IL-1 beta-induced TNF-alpha expression in a dose-dependent manner.	Staurosporine	46-59	interleukin 18	Rattus norvegicus	70-79
1334553-15	1992	Activation of FcRF gamma by IFN-gamma was inhibited by pretreatment with 500 nM staurosporin and 25 microM phenyl arsine oxide.	Staurosporine	80-92	interferon gamma	Homo sapiens	28-37
1460280-8	1992	Two protein kinase C (PKC) inhibitors, H7 and staurosporine, abrogate IFN-gamma/LPS- and IFN-gamma/IL-1 beta-induced TNF-alpha expression in a dose-dependent manner.	Staurosporine	46-59	interleukin 18	Rattus norvegicus	89-98
1460280-8	1992	Two protein kinase C (PKC) inhibitors, H7 and staurosporine, abrogate IFN-gamma/LPS- and IFN-gamma/IL-1 beta-induced TNF-alpha expression in a dose-dependent manner.	Staurosporine	46-59	interleukin 1 beta	Rattus norvegicus	99-108
1460280-8	1992	Two protein kinase C (PKC) inhibitors, H7 and staurosporine, abrogate IFN-gamma/LPS- and IFN-gamma/IL-1 beta-induced TNF-alpha expression in a dose-dependent manner.	Staurosporine	46-59	tumor necrosis factor	Rattus norvegicus	117-126
1459737-9	1992	In the present study, bcl-2 was additionally found to protect from apoptosis driven by staurosporine.	Staurosporine	87-100	BCL2 apoptosis regulator	Homo sapiens	22-27
1292682-6	1992	The treatments of VSMC with H-7 and staurosporine (PK-C) inhibitors prevented the pHi response to endothelin and PMA.	Staurosporine	36-49	glucose-6-phosphate isomerase	Rattus norvegicus	82-85
1444457-6	1992	Only the effect of the inhibitors on up-regulation of PKC-alpha was closely correlated with TPA-induced annexin I expression; staurosporine inhibited up-regulation of PKC-alpha but other inhibitors did not similarly affect the induction of annexin I expression.	Staurosporine	126-139	protein kinase C alpha	Homo sapiens	167-176
1338082-12	1992	Staurosporine, a protein kinase C inhibitor, reduced the suppression by TPA alone or by vasopressin with TPA pretreatment almost to the control level.	Staurosporine	0-13	arginine vasopressin	Rattus norvegicus	88-99
1332852-6	1992	The increase in both 80K protein phosphorylation and hPL release in response to apoAI was prevented by pretreatment of the cells with the PKC inhibitor staurosporine (10 microM) or by down-regulation of PKC after extended preincubation of the cells with 16 microM PMA.	Staurosporine	152-165	galectin 1	Homo sapiens	53-56
1332852-6	1992	The increase in both 80K protein phosphorylation and hPL release in response to apoAI was prevented by pretreatment of the cells with the PKC inhibitor staurosporine (10 microM) or by down-regulation of PKC after extended preincubation of the cells with 16 microM PMA.	Staurosporine	152-165	proline rich transmembrane protein 2	Homo sapiens	138-141
1446598-1	1992	The effects of the phorbol ester 12-O-tetradecanoyl phorbol 13-acetate (TPA), an activator of protein kinase C (PKC), and the PKC inhibitor staurosporine on GnRH secretion and mRNA levels were studied in GT1-7 hypothalamic neuronal cells.	Staurosporine	140-153	gonadotropin releasing hormone 1	Mus musculus	157-161
1334973-6	1992	Physiologic concentrations (10(-11)-10(-10) M) of rat PTH 1-34 fragment increased PKC translocation three- to fourfold while PKA activity ratio increased at PTH 10(-7) M. PTH stimulation of PKC and PKA was reduced in the presence of staurosporine (10 nM) by 41 and 29%, respectively.	Staurosporine	233-246	parathyroid hormone	Rattus norvegicus	54-59
1334973-6	1992	Physiologic concentrations (10(-11)-10(-10) M) of rat PTH 1-34 fragment increased PKC translocation three- to fourfold while PKA activity ratio increased at PTH 10(-7) M. PTH stimulation of PKC and PKA was reduced in the presence of staurosporine (10 nM) by 41 and 29%, respectively.	Staurosporine	233-246	parathyroid hormone	Rattus norvegicus	54-57
1333514-11	1992	Despite the absence of increased plasma membrane protein kinase C activity up to 4 hours after interleukin 1, pretreatment of human umbilical vein endothelium monolayers with staurosporine or phorbol myristate acetate (18 hours) to reduce protein kinase C activities, significantly attenuated the interleukin 1-stimulated prostanoid responses at 16 hours but not at 4 hours.	Staurosporine	175-188	interleukin 1 alpha	Homo sapiens	297-310
1335246-4	1992	This suggests that the effect of staurosporine in FMLP-stimulated neutrophils may be mediated by the action of endogenously produced PAF, which in turn leads to an increase in [Ca2+]i and PAF formation.	Staurosporine	33-46	PCNA clamp associated factor	Homo sapiens	188-191
1335247-4	1992	Shedding of the IL-6R is strongly activated by PMA and can be inhibited by the protein kinase inhibitor staurosporine.	Staurosporine	104-117	interleukin 6 receptor	Homo sapiens	16-21
1459201-7	1992	In contrast, two inhibitors, H-7 and staurosporine, for which protein kinase C is a common target, increase two- to fourfold the attachment of HT1080, OVCAR-4, and B16F10 cells to laminin but not to fibronectin.	Staurosporine	37-50	fibronectin 1	Mus musculus	199-210
1459203-7	1992	At this concentration staurosporine also inhibited the internalization of iodinated transferrin by HepG2 cells and SK Hep-1 cells, another human hepatoma-derived cell line.	Staurosporine	22-35	transferrin	Homo sapiens	84-95
1467312-7	1992	The effect of PMA on calcyclin expression was blocked by the simultaneous addition of the PKC inhibitor staurosporine and by protein synthesis inhibition with cycloheximide.	Staurosporine	104-117	S100 calcium binding protein A6	Homo sapiens	21-30
1464736-10	1992	Protein kinase C inhibitor staurosporine, but not cyclic nucleotide-dependent protein kinase inhibitor HA-1004, also dramatically reduced constitutive levels of nuclear NF kappa B.	Staurosporine	27-40	nuclear factor kappa B subunit 1	Homo sapiens	169-179
1332693-11	1992	Staurosporine, a protein kinase C inhibitor, blocked the action of PMA on pHi, but it had no effect on the ionomycin-induced increase in pHi.	Staurosporine	0-13	glucose-6-phosphate isomerase	Homo sapiens	74-77
1429672-8	1992	Protein kinase C inhibitors, such as H7 (1-(5-isoquinolinylsulfonyl)-2-methylpiperazine), staurosporine, and sphingosine, reduce TNF alpha secretion stimulated by PMA.	Staurosporine	90-103	tumor necrosis factor	Homo sapiens	129-138
1292632-8	1992	Glucocorticoids did not detectably affect IL-1 alpha or IL-1 beta mRNA levels following PMA induction, however, staurosporin inhibited IL-1 beta mRNA synthesis.	Staurosporine	112-124	interleukin 1 beta	Homo sapiens	135-144
1327578-6	1992	The enhancement of ICa,T by ET-1 was antagonized by protein kinase C inhibitors staurosporine (0.2 microM) and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7, 20 microM) applied to the pipette solution.	Staurosporine	80-93	endothelin 1	Rattus norvegicus	28-32
1469061-5	1992	Most likely, protein kinase C is responsible for the phosphorylation of vinculin, since phosphorylation also occurs when platelets are treated with a phorbol ester, which activates protein kinase C, and is blocked by treatment with a staurosporine derivative which inhibits this enzyme.	Staurosporine	234-247	vinculin	Homo sapiens	72-80
1425689-3	1992	Treatment of these cells with two analogues of staurosporine, which are potent inhibitors of PKC, completely blocked the induction by IFN alpha of the mRNA for 2",5"-oligoadenylate synthetase and the 6-16 gene.	Staurosporine	47-60	interferon alpha 1	Homo sapiens	134-143
1425422-3	1992	Induction of acrosome reaction by 12-O-tetradecanoyl phorbol-13-acetate was blocked by the PKC inhibitor staurosporine or by down-regulation of endogenous PKC, but not by removal of extracellular Ca2+.	Staurosporine	105-118	proline rich transmembrane protein 2	Homo sapiens	91-94
1331412-5	1992	The thrombin effect 1) produced an increase in the efficacy of the prostaglandins with no change in potency; 2) was long-lived; 3) required the proteolytic activity of thrombin; 4) was insensitive to pertussis toxin; and 5) was at least partially mimicked by trypsin, extracellular ATP and UTP, platelet activating factor and activators of protein kinase C. Down-regulation of protein kinase C or pre-exposure to the protein kinase inhibitor staurosporine blocked the potentiating effect.	Staurosporine	442-455	coagulation factor II, thrombin	Homo sapiens	4-12
1402922-6	1992	Although a protein kinase C (PKC) inhibitor, staurosporine (5 microM), blocked PMA-induced [3H]PEt formation by 77%, it had no effect on the CCh-induced formation.	Staurosporine	45-58	protein kinase C, gamma	Rattus norvegicus	11-27
1402922-6	1992	Although a protein kinase C (PKC) inhibitor, staurosporine (5 microM), blocked PMA-induced [3H]PEt formation by 77%, it had no effect on the CCh-induced formation.	Staurosporine	45-58	protein kinase C, gamma	Rattus norvegicus	29-32
1282220-7	1992	Similarly, the PKC inhibitors, polymyxin B and staurosporine, blocked effects of both PMA and Bay K 8644 on K(+)-stimulated release of [3H]5-HT.	Staurosporine	47-60	protein kinase C, gamma	Rattus norvegicus	15-18
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	Staurosporine	144-157	tumor necrosis factor	Mus musculus	4-31
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	Staurosporine	144-157	tumor necrosis factor	Mus musculus	34-43
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	Staurosporine	144-157	interleukin 1 complex	Mus musculus	49-68
1282723-2	1992	The tumor necrosis factor-alpha- (TNF-alpha) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C.	Staurosporine	144-157	intercellular adhesion molecule 1	Mus musculus	81-87
1284912-4	1992	Protein kinase C inhibitors (H-7 and staurosporine) but not a protein kinase A inhibitor (HA1004) significantly suppressed the ALP activity induced by the simultaneous treatment with RA and rhG-CSF.	Staurosporine	37-50	alkaline phosphatase, placental	Homo sapiens	127-130
1450954-4	1992	Pretreatment with staurosporine, K252a and H-7 attenuated decreases in 2-DG uptake and CA1 field potentials.	Staurosporine	18-31	carbonic anhydrase 1	Rattus norvegicus	87-90
1327540-4	1992	To investigate the intracellular pathway involved in the TNF-mediated activation of mycobacteriostatic/mycobactericidal activity in macrophages, we used two different protein kinase C (PKC) inhibitors: H7 (10(-5)-10(7) M) and staurosporine (10(-7)-10(-9) M).	Staurosporine	226-239	tumor necrosis factor	Homo sapiens	57-60
1417980-9	1992	Interleukin 2 (IL-2)-driven mitogenesis in IL-2-dependent cells was also inhibited by staurosporine.	Staurosporine	86-99	interleukin 2	Homo sapiens	0-13
1417980-9	1992	Interleukin 2 (IL-2)-driven mitogenesis in IL-2-dependent cells was also inhibited by staurosporine.	Staurosporine	86-99	interleukin 2	Homo sapiens	15-19
1417980-9	1992	Interleukin 2 (IL-2)-driven mitogenesis in IL-2-dependent cells was also inhibited by staurosporine.	Staurosporine	86-99	interleukin 2	Homo sapiens	43-47
1396321-9	1992	Both desensitization to PTH and receptor down-regulation were induced, however, by pretreatment with a phorbol ester (12-O-tetradecanoyl phorbol-13-acetate), and these effects were blocked completely by staurosporine.	Staurosporine	203-216	parathyroid hormone	Homo sapiens	24-40
1325299-6	1992	Inhibition of protein kinase C activity by 100 nM staurosporine relaxed ET-1 plus GTP-induced contractions, and pretreatment with 40 microM chelerythrine inhibited the ET-1 plus GTP increase in force.	Staurosporine	50-63	endothelin-1	Oryctolagus cuniculus	72-76
1356818-6	1992	The induction of TG1 mRNA expression by TPA was inhibited by 1-(5-isoquinolinylsulfonyl)-2-methyl-piperazine (H-7) and staurosporine.	Staurosporine	119-132	transglutaminase 1	Homo sapiens	17-20
1280722-5	1992	The effect of angiotensin II on gj was suppressed by staurosporine--a potent inhibitor of protein kinase C. This finding indicates that the peptide is changing gj through activation of protein kinase C. The increase in cell coupling caused by enalapril raises the possibility that the antiarrhythmic action of enalapril as well its effect in congestive heart failure are related to an increase in electrical synchronization of cardiac myocytes.	Staurosporine	53-66	angiotensinogen	Rattus norvegicus	14-28
1522136-10	1992	In addition, BPAEC pretreatment with the PKC inhibitor, staurosporine, prevented alpha-thrombin- and PMA-induced phosphorylation of both cytoskeletal proteins, attenuated morphologic evidence of contraction, and abolished agonist-induced barrier dysfunction.	Staurosporine	56-69	coagulation factor II, thrombin	Bos taurus	87-95
1356124-2	1992	Regulation of the avidity of LFA-1 (CD11a/CD18, alpha L beta 2) for its ligand ICAM-1 (CD54) was studied in human B cells by evaluating the effects of a phorbol ester, anti-IgM antibodies, staurosporine, and okadaic acid.	Staurosporine	189-202	integrin subunit alpha L	Homo sapiens	29-34
1356124-4	1992	In this assay, the protein kinase C-activating phorbol ester PDB and anti-IgM antibodies, as well as the protein kinase inhibitor, staurosporine, were able to induce LFA-1-dependent binding to ICAM-1.	Staurosporine	131-144	integrin subunit alpha L	Homo sapiens	166-171
1356124-4	1992	In this assay, the protein kinase C-activating phorbol ester PDB and anti-IgM antibodies, as well as the protein kinase inhibitor, staurosporine, were able to induce LFA-1-dependent binding to ICAM-1.	Staurosporine	131-144	intercellular adhesion molecule 1	Homo sapiens	193-199
1356124-7	1992	Treatment with staurosporine before addition of okadaic acid not only induced enhanced binding of cells to ICAM-1, but also dramatically reduced the ability of okadaic acid to inhibit binding.	Staurosporine	15-28	intercellular adhesion molecule 1	Homo sapiens	107-113
1407458-7	1992	Epidermal growth factor and fibroblast growth factor increased both PKC activity and the growth rate of glioma line A172; addition of SP reduced the growth rate to levels observed in SP-treated control tumors, indicating that PKC may be a common signal transduction system induced by these mitogens.	Staurosporine	183-185	epidermal growth factor	Homo sapiens	0-23
1417754-7	1992	The thrombin response was, however, inhibited by the non-specific protein kinase inhibitor staurosporine.	Staurosporine	91-104	coagulation factor II, thrombin	Homo sapiens	4-12
1527011-8	1992	Internalization and degradation of CD4 was blocked by staurosporine, an inhibitor of protein kinase C suggestive of a role for protein kinase C in the endocytic fate of CD4.	Staurosporine	54-67	CD4 molecule	Homo sapiens	35-38
1527011-8	1992	Internalization and degradation of CD4 was blocked by staurosporine, an inhibitor of protein kinase C suggestive of a role for protein kinase C in the endocytic fate of CD4.	Staurosporine	54-67	CD4 molecule	Homo sapiens	169-172
1384467-10	1992	However, mIg-stimulated MAP kinase activation and pp42 tyrosine phosphorylation was only partially blocked by a PKC inhibitor, the staurosporine analogue Compound 3.	Staurosporine	131-144	chemokine (C-X-C motif) ligand 9	Mus musculus	9-12
1394140-7	1992	Submicromolar concentrations of CGP 41251 and staurosporine directly inhibited both the platelet-derived growth factor (PDGF) receptor autophosphorylation and the c-fos mRNA expression induced by PDGF stimulation of intact BALB/c 3T3 cells.	Staurosporine	46-59	FBJ osteosarcoma oncogene	Mus musculus	163-168
1426027-2	1992	Staurosporine, a potent protein kinase C inhibitor, also induced ODC activity.	Staurosporine	0-13	ornithine decarboxylase, structural 1	Mus musculus	65-68
1426027-3	1992	Both TPA- and staurosporine-caused ODC inductions were markedly suppressed in the PKC-down-regulated cells.	Staurosporine	14-27	ornithine decarboxylase, structural 1	Mus musculus	35-38
1426027-4	1992	Another PKC inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), inhibited both TPA- and staurosporine-caused ODC inductions.	Staurosporine	100-113	ornithine decarboxylase, structural 1	Mus musculus	121-124
1426027-7	1992	TPA induced a translocation of PKC from cytosol to membrane whereas an optimal concentration of staurosporine to induce ODC did not induce an obvious translocation of PKC.	Staurosporine	96-109	ornithine decarboxylase, structural 1	Mus musculus	120-123
1426027-8	1992	Indomethacin, a cyclooxygenase inhibitor, inhibited staurosporine-caused ODC induction, but not TPA-caused ODC induction.	Staurosporine	52-65	ornithine decarboxylase, structural 1	Mus musculus	73-76
1426027-10	1992	These results indicate that staurosporine induces ODC activity in a PKC-dependent manner and morphological changes possibly through a PKC-independent mechanism.	Staurosporine	28-41	ornithine decarboxylase, structural 1	Mus musculus	50-53
1426027-11	1992	The mechanism of ODC induction caused by staurosporine may be in some way different from that caused by TPA.	Staurosporine	41-54	ornithine decarboxylase, structural 1	Mus musculus	17-20
1456083-8	1992	The effects of PDGF, EGF, and bFGF were inhibited by H-7 or staurosporine, inhibitors of protein kinase C (PKC), but not by HA1004 with a much weaker inhibitory activity, suggesting the involvement of PKC for the activation of the protooncogenes.	Staurosporine	60-73	fibroblast growth factor 2	Mus musculus	30-34
1334143-9	1992	The simulation of TNF release caused by treatment with immunoglobulin-opsonized long fibre amosite could be inhibited by treatment of the macrophages with the protein kinase C-inhibitor staurosporine.	Staurosporine	186-199	tumor necrosis factor	Rattus norvegicus	18-21
1384497-9	1992	by G-CSF was inhibited by genistein or alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide (ST 638), inhibitors of tyrosine kinase (TK), and was stimulated by staurosporine and 1-(5-isoquinolinesulfonyl)-3-methyl-piperazine (H-7), inhibitors of PKC.	Staurosporine	168-181	colony stimulating factor 3	Homo sapiens	3-8
1384497-9	1992	by G-CSF was inhibited by genistein or alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide (ST 638), inhibitors of tyrosine kinase (TK), and was stimulated by staurosporine and 1-(5-isoquinolinesulfonyl)-3-methyl-piperazine (H-7), inhibitors of PKC.	Staurosporine	168-181	TXK tyrosine kinase	Homo sapiens	124-139
1527003-6	1992	In islets exposed to G20 + 50 nM staurosporine, MARCKS phosphorylation was inhibited by 90 +/- 4% compared with control islets exposed to 20 mM glucose alone.	Staurosporine	33-46	myristoylated alanine rich protein kinase C substrate	Rattus norvegicus	48-54
1382409-3	1992	Pretreatment of cells with genistein or methyl-2,5-dihydroxycinnamate (tyrosine kinase inhibitors) or staurosporine (a protein kinase C inhibitor) for 20 min abolished the c-fos expression induced by PAF.	Staurosporine	102-115	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	172-177
1442121-1	1992	The presence of protein kinase C (PKC) in proximal tubule cells of the rat kidney is established by means of immunodetection and by the demonstration of calcium- and phospholipid-dependent, staurosporine-inhibitable histone phosphorylation.	Staurosporine	190-203	protein kinase C, gamma	Rattus norvegicus	16-32
1442121-1	1992	The presence of protein kinase C (PKC) in proximal tubule cells of the rat kidney is established by means of immunodetection and by the demonstration of calcium- and phospholipid-dependent, staurosporine-inhibitable histone phosphorylation.	Staurosporine	190-203	protein kinase C, gamma	Rattus norvegicus	34-37
1382409-3	1992	Pretreatment of cells with genistein or methyl-2,5-dihydroxycinnamate (tyrosine kinase inhibitors) or staurosporine (a protein kinase C inhibitor) for 20 min abolished the c-fos expression induced by PAF.	Staurosporine	102-115	PCNA clamp associated factor	Homo sapiens	200-203
1355014-7	1992	Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression.	Staurosporine	0-12	interferon gamma	Homo sapiens	71-80
1355014-7	1992	Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression.	Staurosporine	0-12	intercellular adhesion molecule 1	Homo sapiens	114-120
1355014-7	1992	Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression.	Staurosporine	0-12	interferon gamma	Homo sapiens	256-265
1355014-7	1992	Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression.	Staurosporine	0-12	intercellular adhesion molecule 1	Homo sapiens	285-291
1355014-7	1992	Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression.	Staurosporine	0-12	integrin subunit alpha L	Homo sapiens	328-333
1355014-7	1992	Staurosporin, an inhibitor of protein kinases (PKs), partly suppressed IFN-gamma- and PMA-augmented expression of ICAM-1 on EoL-3 and U937 cells, but did not affect PMA-augmented LFA-1 expression, suggesting that staurosporin-sensitive PKs are involved in IFN-gamma- and PMA-augmented ICAM-1 expression but not in PMA-augmented LFA-1 expression.	Staurosporine	213-225	intercellular adhesion molecule 1	Homo sapiens	114-120
1421576-6	1992	Staurosporine, a kinase inhibitor known to effect dissolution but not contraction of stress fibers, immediately caused an increase in MHC and LC20 phosphorylation followed within minutes by the dephosphorylation of LC20 to a level below that of untreated cells.	Staurosporine	0-13	major histocompatibility complex, class I, C	Homo sapiens	134-137
1524403-5	1992	Furthermore, it has been shown that the cellular effects of oncogenic p21 protein can be completely inhibited by selectively blocking protein kinase C (PKC) with a highly specific inhibitor of this protein, CGP 41 251, a staurosporine derivative.	Staurosporine	221-234	H3 histone pseudogene 16	Homo sapiens	70-73
1324162-6	1992	Perifusion of tubule cells with the protein kinase-C (PKC) inhibitor staurosporine blocked the PTH-induced increase in 1,25-(OH)2D3 secretion.	Staurosporine	69-82	parathyroid hormone	Rattus norvegicus	95-98
1494907-5	1992	The CSF-1 mRNA levels were strongly reduced by incubating immortalized astrocytic cells with staurosporine, a protein kinase C inhibitor, both in the absence and in the presence of cytokines.	Staurosporine	93-106	colony stimulating factor 1 (macrophage)	Mus musculus	4-9
1421576-6	1992	Staurosporine, a kinase inhibitor known to effect dissolution but not contraction of stress fibers, immediately caused an increase in MHC and LC20 phosphorylation followed within minutes by the dephosphorylation of LC20 to a level below that of untreated cells.	Staurosporine	0-13	myosin light chain 9	Homo sapiens	142-146
1421576-6	1992	Staurosporine, a kinase inhibitor known to effect dissolution but not contraction of stress fibers, immediately caused an increase in MHC and LC20 phosphorylation followed within minutes by the dephosphorylation of LC20 to a level below that of untreated cells.	Staurosporine	0-13	myosin light chain 9	Homo sapiens	215-219
1324189-3	1992	In the presence of staurosporine, a PKC inhibitor, the inhibitory effect of PMA on CNP-stimulated cGMP production was reversed.	Staurosporine	19-32	natriuretic peptide type C	Mus musculus	83-86
1379589-5	1992	In a similar fashion, the down-regulation of CFTR transcript levels by A23187 was blocked by H7 as well as staurosporine, another protein kinase inhibitor.	Staurosporine	107-120	CF transmembrane conductance regulator	Homo sapiens	45-49
1330596-1	1992	Staurosporine, a putative protein kinase C (PKC) inhibitor, increased the release of [14C]arachidonic acid dose dependently between 100 nM and 1000 nM in human neutrophils challenged with 100 nM N-formyl-methionine-leucine-phenylalanine (FMLP).	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	238-242
1330596-3	1992	In addition, exogenously added lyso-PAF further augmented [3H]PAF formation in staurosporine-pretreated human neutrophils stimulated by FMLP, thus suggesting an activation of acetyl-CoA: lyso-PAF acetyltransferase by staurosporine.	Staurosporine	79-92	formyl peptide receptor 1	Homo sapiens	136-140
1514580-5	1992	Angiotensin II increased RNA content by 28% at 48 h but had no effect on growth up to 72 h. Growth stimulation and increased nuclear protein kinase C (PKC) activity were induced by contraction, NE, and PMA treatment and were inhibited by staurosporine (a PKC inhibitor), suggestive of a central role for PKC.	Staurosporine	238-251	angiotensinogen	Homo sapiens	0-14
1379589-6	1992	Interestingly, both H7 and staurosporine themselves increased CFTR mRNA levels.	Staurosporine	27-40	CF transmembrane conductance regulator	Homo sapiens	62-66
1639861-4	1992	Two PKC inhibitors, H7 and staurosporine (SS), abrogated IL-1 beta induced TNF-alpha expression in a dose-dependent fashion.	Staurosporine	27-40	interleukin 1 beta	Homo sapiens	57-66
1379255-8	1992	Staurosporine (STS), a potent PKC inhibitor, stimulated IGFBP-1 production 2- to 4-fold and augmented the stimulatory effect of PMA.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	30-33
1379255-8	1992	Staurosporine (STS), a potent PKC inhibitor, stimulated IGFBP-1 production 2- to 4-fold and augmented the stimulatory effect of PMA.	Staurosporine	0-13	insulin like growth factor binding protein 1	Homo sapiens	56-63
1379255-8	1992	Staurosporine (STS), a potent PKC inhibitor, stimulated IGFBP-1 production 2- to 4-fold and augmented the stimulatory effect of PMA.	Staurosporine	15-18	proline rich transmembrane protein 2	Homo sapiens	30-33
1379255-8	1992	Staurosporine (STS), a potent PKC inhibitor, stimulated IGFBP-1 production 2- to 4-fold and augmented the stimulatory effect of PMA.	Staurosporine	15-18	insulin like growth factor binding protein 1	Homo sapiens	56-63
1639861-4	1992	Two PKC inhibitors, H7 and staurosporine (SS), abrogated IL-1 beta induced TNF-alpha expression in a dose-dependent fashion.	Staurosporine	27-40	tumor necrosis factor	Homo sapiens	75-84
1639861-4	1992	Two PKC inhibitors, H7 and staurosporine (SS), abrogated IL-1 beta induced TNF-alpha expression in a dose-dependent fashion.	Staurosporine	42-44	interleukin 1 beta	Homo sapiens	57-66
1639861-4	1992	Two PKC inhibitors, H7 and staurosporine (SS), abrogated IL-1 beta induced TNF-alpha expression in a dose-dependent fashion.	Staurosporine	42-44	tumor necrosis factor	Homo sapiens	75-84
1638633-5	1992	Phosphoamino acid analyses of 32P-labeled ISGF3 alpha proteins confirm that ISGF3 alpha proteins are directly tyrosine phosphorylated both in vitro and in vivo in response to interferon alpha, and this tyrosine phosphorylation can be inhibited by staurosporine and genistein.	Staurosporine	247-260	interferon regulatory factor 9	Homo sapiens	76-81
1629741-6	1992	Of the three structurally related nerve growth factor inhibitors, K-252a, K-252b, and staurosporine, only the first two also mediated neurotrophin-3 potentiation.	Staurosporine	86-99	neurotrophin 3	Rattus norvegicus	134-148
1644168-6	1992	It is inhibited by staurosporine with an IC50 of 16 nM, which is within the same range of other PKC isoenzymes.	Staurosporine	19-32	protein kinase C, alpha	Mus musculus	96-99
1644168-7	1992	The sensitivity of PKC zeta towards the staurosporine derivative K252a is similar to that of PKC alpha,beta,gamma but much higher than that of PKC delta and epsilon.	Staurosporine	40-53	protein kinase C, alpha	Mus musculus	93-102
1419482-7	1992	At similar concentrations, staurosporine stimulates insulin or progesterone action, but, when added after about 2 h, the drug inhibits induction by insulin.	Staurosporine	27-40	insulin S homeolog	Xenopus laevis	52-59
1322131-7	1992	Staurosporine, an inhibitor of protein kinase C, prevented the increase in PFK-2 activity brought about by the shift to the permissive temperature.	Staurosporine	0-13	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	Homo sapiens	75-80
1322051-7	1992	The O2- response to C5a but not to TNF-alpha was abolished by pretreatment with the inhibitor of protein kinase C, staurosporine.	Staurosporine	115-128	complement C5a receptor 1	Homo sapiens	20-23
1322053-9	1992	Staurosporine and calphostin C, inhibitors of protein kinase C, completely blocked the decrease in Isc caused by simultaneous addition of ANF and BK.	Staurosporine	0-13	natriuretic peptide A	Homo sapiens	138-141
1322053-9	1992	Staurosporine and calphostin C, inhibitors of protein kinase C, completely blocked the decrease in Isc caused by simultaneous addition of ANF and BK.	Staurosporine	0-13	kininogen 1	Homo sapiens	146-148
1644861-10	1992	In addition, staurosporine was about 2-4 order of magnitudes less effective in inhibiting the protein kinase activities of PKC-delta and PKC-zeta when compared to PKC-alpha.	Staurosporine	13-26	protein kinase C, delta	Rattus norvegicus	123-132
1628655-4	1992	Since TPA activates protein kinase C (PKC), other PKC-activating phorbol-ester analogues were tested and found to be effective, whereas the PKC inhibitor staurosporine reduced the potentiative activity of TPA.	Staurosporine	154-167	plasminogen activator, tissue type	Homo sapiens	6-9
1628655-4	1992	Since TPA activates protein kinase C (PKC), other PKC-activating phorbol-ester analogues were tested and found to be effective, whereas the PKC inhibitor staurosporine reduced the potentiative activity of TPA.	Staurosporine	154-167	plasminogen activator, tissue type	Homo sapiens	205-208
1516571-8	1992	That the capacity of PMA to modulate AA metabolism was mediated by activation of PKC was confirmed by demonstrating that (1) phorbol didecanoate, which lacks the ability to activate PKC, failed to activate AA metabolism; (2) pretreatment for 18 h with 1 microM PMA, which depletes cellular PKC, abolished subsequent AA metabolism activated by 50 nM PMA; and (3) the PKC inhibitor staurosporine abrogated increases in the quantities of both free AA and prostaglandin E2 in response to PMA.	Staurosporine	380-393	protein kinase C, gamma	Rattus norvegicus	81-84
1320036-8	1992	MARCKS phosphorylation can also be induced by several exogenous protein kinase C (PKC) activators and both alpha-thrombin- and histamine-induced MARCKS phosphorylation are inhibited by the PKC antagonist staurosporine.	Staurosporine	204-217	myristoylated alanine rich protein kinase C substrate	Homo sapiens	0-6
1320036-8	1992	MARCKS phosphorylation can also be induced by several exogenous protein kinase C (PKC) activators and both alpha-thrombin- and histamine-induced MARCKS phosphorylation are inhibited by the PKC antagonist staurosporine.	Staurosporine	204-217	coagulation factor II, thrombin	Homo sapiens	113-121
1320036-8	1992	MARCKS phosphorylation can also be induced by several exogenous protein kinase C (PKC) activators and both alpha-thrombin- and histamine-induced MARCKS phosphorylation are inhibited by the PKC antagonist staurosporine.	Staurosporine	204-217	myristoylated alanine rich protein kinase C substrate	Homo sapiens	145-151
1635552-1	1992	The protein kinase C (PKC) inhibitor staurosporine, a member of the K252a family of fungal alkaloids that are known as protein kinase inhibitors, induces neurite outgrowth in pheochromocytoma PC12 cells.	Staurosporine	37-50	protein kinase C, gamma	Rattus norvegicus	4-20
1635552-1	1992	The protein kinase C (PKC) inhibitor staurosporine, a member of the K252a family of fungal alkaloids that are known as protein kinase inhibitors, induces neurite outgrowth in pheochromocytoma PC12 cells.	Staurosporine	37-50	protein kinase C, gamma	Rattus norvegicus	22-25
1635552-9	1992	At neurotropic concentrations of staurosporine, PKC in PC12 cells was completely inhibited.	Staurosporine	33-46	protein kinase C, gamma	Rattus norvegicus	48-51
1635552-10	1992	When PKC activity was down-regulated by prolonged exposure to phorbol myristate acetate, PC12 cells responded to staurosporine with neurite outgrowth similar to that of untreated cells.	Staurosporine	113-126	protein kinase C, gamma	Rattus norvegicus	5-8
1320409-0	1992	Effect of staurosporine on fMet-Leu-Phe-stimulated human neutrophils: dissociated release of inositol 1,4,5-trisphosphate, diacylglycerol and intracellular calcium.	Staurosporine	10-23	formyl peptide receptor 1	Homo sapiens	27-39
1631101-5	1992	Pretreatment of cells with staurosporin blocked the ATP-mediated phosphorylation of cPLA2 and strongly inhibited the activation of the enzyme.	Staurosporine	27-39	cytosolic phospholipase A2	Cricetulus griseus	84-89
1320409-1	1992	Staurosporine, a microbial alkaloid, enhances inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DG) production rapidly and dose-dependently in fMet-Leu-Phe (FMLP)-stimulated human neutrophils showing maximal effects at 1 microM concentration.	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	152-164
1320409-1	1992	Staurosporine, a microbial alkaloid, enhances inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DG) production rapidly and dose-dependently in fMet-Leu-Phe (FMLP)-stimulated human neutrophils showing maximal effects at 1 microM concentration.	Staurosporine	0-13	formyl peptide receptor 1	Homo sapiens	166-170
1320409-8	1992	This phenomenon is attributed to phospholipase D (PLD) stimulation by staurosporine, which augments the DG synthesis, in part through PA degradation via phosphatidic acid (PA) phosphohydrolase.	Staurosporine	70-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-48
1320409-8	1992	This phenomenon is attributed to phospholipase D (PLD) stimulation by staurosporine, which augments the DG synthesis, in part through PA degradation via phosphatidic acid (PA) phosphohydrolase.	Staurosporine	70-83	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	50-53
1323351-5	1992	The attempt to dissect these differences revealed that the kinase inhibitors K-252a and staurosporine inhibit RTK autophosphorylation and thus the biological consequences of receptor/ligand interaction.	Staurosporine	88-101	erb-b2 receptor tyrosine kinase 4	Rattus norvegicus	110-113
1351792-1	1992	Activities of a newly synthesized compound, N-ethoxycarbonyl-7-oxo-staurosporine (NA-382), on cyclic AMP-dependent protein kinase (A-kinase), Ca2+/phospholipid dependent protein kinase (C-kinase), and drug resistance were investigated and compared with those of staurosporine.	Staurosporine	67-80	mitogen-activated protein kinase kinase kinase 14	Mus musculus	115-129
1351792-1	1992	Activities of a newly synthesized compound, N-ethoxycarbonyl-7-oxo-staurosporine (NA-382), on cyclic AMP-dependent protein kinase (A-kinase), Ca2+/phospholipid dependent protein kinase (C-kinase), and drug resistance were investigated and compared with those of staurosporine.	Staurosporine	67-80	mitogen-activated protein kinase kinase kinase 14	Mus musculus	170-184
1351792-2	1992	Protein kinase-inhibitory activity of NA-382 was lower but more selective to C-kinase than that of staurosporine.	Staurosporine	99-112	mitogen-activated protein kinase kinase kinase 14	Mus musculus	0-14
1434124-3	1992	Both K-252a (10-200 nM) and staurosporine (1-100 nM) blocked the survival-promoting effects of EGF in a concentration-dependent manner.	Staurosporine	28-41	epidermal growth factor like 1	Rattus norvegicus	95-98
1634016-2	1992	The present results indicate that induction of the LHRH priming effect is inhibited in a concentration-dependent manner by the protein kinase C (PKC) inhibitors staurosporine, K252a, H7 and by the novel highly-selective PKC inhibitor, Ro 31-8220.	Staurosporine	161-174	gonadotropin releasing hormone 1	Homo sapiens	51-55
1321770-5	1992	This inhibitory action of TPA on inositol phosphate production was mimicked by diacylglycerol analogues and was reversed by staurosporine, H-7 and tamoxifen, all known inhibitors of PKC.	Staurosporine	124-137	proline rich transmembrane protein 2	Homo sapiens	182-185
1634016-9	1992	Staurosporine, K252a and Ro 31-8220 inhibited LHRH priming with identical potencies to their inhibition of phorbol ester-induced gonadotropin secretion.	Staurosporine	0-13	gonadotropin releasing hormone 1	Homo sapiens	46-50
1315776-6	1992	Second, the use of three inhibitors of protein kinase C (PKC), H7, staurosporine, and sphingosine, in concentrations that are below their toxicity limits, revert the suppression of apoptosis by IL-3 and GM-CSF.	Staurosporine	67-80	interleukin 3	Homo sapiens	194-198
1315776-6	1992	Second, the use of three inhibitors of protein kinase C (PKC), H7, staurosporine, and sphingosine, in concentrations that are below their toxicity limits, revert the suppression of apoptosis by IL-3 and GM-CSF.	Staurosporine	67-80	colony stimulating factor 2	Homo sapiens	203-209
1315776-12	1992	Preincubation of the cells with staurosporine, a PKC inhibitor, also significantly reduces the effect of GM-CSF or IL-3 on pHi.	Staurosporine	32-45	colony stimulating factor 2	Homo sapiens	105-111
1315776-12	1992	Preincubation of the cells with staurosporine, a PKC inhibitor, also significantly reduces the effect of GM-CSF or IL-3 on pHi.	Staurosporine	32-45	interleukin 3	Homo sapiens	115-119
1317101-9	1992	Staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, two structurally different inhibitors of PKC activity, inhibited basal and stimulated EPO production with ED50 values of 9 nM and 50 microM, respectively.	Staurosporine	0-13	erythropoietin	Homo sapiens	152-155
1446322-7	1992	In contrast, staurosporine (a putative inhibitor of protein kinase C) substantially inhibited the U46619 and bradykinin dependent release of 6-oxo-PGF1 alpha.	Staurosporine	13-26	kininogen 1	Bos taurus	109-119
1397536-0	1992	Effect of staurosporine derivatives on IL-1-stimulated prostaglandin E production.	Staurosporine	10-23	interleukin 1 alpha	Homo sapiens	39-43
1571555-0	1992	Granulocyte-macrophage colony-stimulating factor induces a staurosporine inhibitable tyrosine phosphorylation of unique neutrophil proteins.	Staurosporine	59-72	colony stimulating factor 2	Homo sapiens	0-48
1571555-9	1992	However, staurosporine was seen to inhibit tyrosine phosphorylation of neutrophil proteins by GM-CSF and in vitro tyrosine kinase activity of isolated neutrophil cytosol and particulate fractions.	Staurosporine	9-22	colony stimulating factor 2	Homo sapiens	94-100
1571555-10	1992	These data indicate that the three unique GM-CSF-induced phosphotyrosine-containing proteins may be responsible for the unique actions of GM-CSF and that staurosporine inhibits a tyrosine kinase responsible for the phosphorylation of these proteins.	Staurosporine	154-167	colony stimulating factor 2	Homo sapiens	42-48
1571555-10	1992	These data indicate that the three unique GM-CSF-induced phosphotyrosine-containing proteins may be responsible for the unique actions of GM-CSF and that staurosporine inhibits a tyrosine kinase responsible for the phosphorylation of these proteins.	Staurosporine	154-167	colony stimulating factor 2	Homo sapiens	138-144
1314657-0	1992	Inhibition of the cellular actions of nerve growth factor by staurosporine and K252A results from the attenuation of the activity of the trk tyrosine kinase.	Staurosporine	61-74	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	137-140
1603084-8	1992	Studies employing sphingosine or staurosporine to inhibit protein kinase-C or preincubation in high doses of PMA to down-regulate protein kinase-C suggested that the effect of PMA on IGF-I and bFGF mRNA levels was mediated by activation of protein kinase-C, although both staurosporine and sphingosine had independent effects on the levels of these mRNAs and down-regulation of protein kinase-C had a sustained effect on IGF-I mRNA levels.	Staurosporine	272-285	insulin-like growth factor 1	Rattus norvegicus	183-188
1603084-8	1992	Studies employing sphingosine or staurosporine to inhibit protein kinase-C or preincubation in high doses of PMA to down-regulate protein kinase-C suggested that the effect of PMA on IGF-I and bFGF mRNA levels was mediated by activation of protein kinase-C, although both staurosporine and sphingosine had independent effects on the levels of these mRNAs and down-regulation of protein kinase-C had a sustained effect on IGF-I mRNA levels.	Staurosporine	272-285	fibroblast growth factor 2	Rattus norvegicus	193-197
1591268-3	1992	The set point of control platelets (7.28 +/- 0.01) is shifted rapidly (discernibly less than or equal to 30 s) and markedly to alkaline pHi (7.62 +/- 0.03) by PMA, that activates protein kinase C and is shifted to acidic pHi (7.05 +/- 0.01) by staurosporine, which inhibits protein kinases.	Staurosporine	244-257	glucose-6-phosphate isomerase	Homo sapiens	136-139
1577171-1	1992	In the human T-cell lymphoma line, HuT 78, proliferation and phorbol ester-induced growth arrest and differentiation were inhibited by the protein kinase C (PKC) inhibitor, staurosporine.	Staurosporine	173-186	protein kinase C alpha	Homo sapiens	157-160
1314112-9	1992	The protein kinase C (PKC) inhibitor staurosporine reduced alpha-thrombin-induced PEt formation in a dose-dependent manner (10 mumol/L, 78% inhibition) and PKC downregulation with chronic PMA treatment (18 hours) also resulted in marked inhibition of alpha-thrombin-induced PEt formation.	Staurosporine	37-50	coagulation factor II, thrombin	Homo sapiens	65-73
1314112-9	1992	The protein kinase C (PKC) inhibitor staurosporine reduced alpha-thrombin-induced PEt formation in a dose-dependent manner (10 mumol/L, 78% inhibition) and PKC downregulation with chronic PMA treatment (18 hours) also resulted in marked inhibition of alpha-thrombin-induced PEt formation.	Staurosporine	37-50	coagulation factor II, thrombin	Homo sapiens	257-265
1567459-0	1992	Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	39-46
1567459-0	1992	Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases.	Staurosporine	0-13	cyclin dependent kinase 1	Homo sapiens	51-58
1567459-3	1992	In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM.	Staurosporine	35-48	cyclin dependent kinase 1	Homo sapiens	87-94
1567459-3	1992	In the present study, we show that staurosporine inhibits the activity of fractionated p34cdc2 and p34cdc2-like kinases with IC50 values of 4-5 nM.	Staurosporine	35-48	cyclin dependent kinase 1	Homo sapiens	99-106
1567459-4	1992	We propose that the G2 phase arrest in the cell cycle caused by staurosporine is due, at least in part, to the inhibition of the p34cdc2 kinases.	Staurosporine	64-77	cyclin dependent kinase 1	Homo sapiens	129-136
1551899-1	1992	The late phase of the time-dependent epidermal growth factor (EGF)-induced biphasic activation of the p70s6k is selectively attenuated by the specific PKC inhibitor, CGP 41,251, a staurosporine derivative.	Staurosporine	180-193	epidermal growth factor	Homo sapiens	37-60
1551899-1	1992	The late phase of the time-dependent epidermal growth factor (EGF)-induced biphasic activation of the p70s6k is selectively attenuated by the specific PKC inhibitor, CGP 41,251, a staurosporine derivative.	Staurosporine	180-193	epidermal growth factor	Homo sapiens	62-65
1551899-1	1992	The late phase of the time-dependent epidermal growth factor (EGF)-induced biphasic activation of the p70s6k is selectively attenuated by the specific PKC inhibitor, CGP 41,251, a staurosporine derivative.	Staurosporine	180-193	ribosomal protein S6 kinase B1	Homo sapiens	102-108
1566820-3	1992	Volume decrease after cell swelling in response to L-Ala (25 mM) was prevented by H-7 (P less than 0.05) or the more potent PKC inhibitor 10 nM staurosporine (P less than 0.001).	Staurosporine	144-157	Prkca	Cavia porcellus	124-127
1312809-4	1992	The oxygen burst induced by FMLP or OZ was inhibited by genistein and alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamid (ST638), which are inhibitors of tyrosine kinase (TK), and was enhanced by 1-(5-isoquinoline-sulfonyl)-3-methyl-piperazine (H-7) and staurosporine, which are inhibitors of protein kinase C (PKC).	Staurosporine	263-276	formyl peptide receptor 1	Homo sapiens	28-32
1312437-5	1992	Pertussis toxin and the protein kinase-C inhibitors, H-7 and staurosporine, all of which enhanced adipocyte differentiation of rat adipose precursor cells, partially reversed ET-1 inhibition.	Staurosporine	61-74	endothelin 1	Rattus norvegicus	175-179
1493432-6	1992	The PLC-induced monocytic differentiation in THP-1 cells was inhibited by staurosporine, a potent PK-C inhibitor, further suggesting that direct activation of the PK-C is one of the metabolic events essential for monocytic differentiation.	Staurosporine	74-87	GLI family zinc finger 2	Homo sapiens	45-50
1493432-6	1992	The PLC-induced monocytic differentiation in THP-1 cells was inhibited by staurosporine, a potent PK-C inhibitor, further suggesting that direct activation of the PK-C is one of the metabolic events essential for monocytic differentiation.	Staurosporine	74-87	proline rich transmembrane protein 2	Homo sapiens	98-102
1493432-6	1992	The PLC-induced monocytic differentiation in THP-1 cells was inhibited by staurosporine, a potent PK-C inhibitor, further suggesting that direct activation of the PK-C is one of the metabolic events essential for monocytic differentiation.	Staurosporine	74-87	proline rich transmembrane protein 2	Homo sapiens	163-167
1575694-7	1992	In combination studies, staurosporine potentiated Ca2+ influx induced by N-formylmethionyl-leucyl-phenylalanine (FMLP) and did not block Ca2+ efflux associated with peptide stimulation of neutrophils.	Staurosporine	24-37	formyl peptide receptor 1	Homo sapiens	113-117
1575694-10	1992	Finally, lysozyme, but not beta-glucuronidase, was released from staurosporine-treated cells.	Staurosporine	65-78	lysozyme	Homo sapiens	9-17
1373168-7	1992	IL-4 most likely utilizes a protein kinase C-independent signal transduction pathway to modify CD20 molecule inasmuch as staurosporine, an inhibitor of protein kinase C, antagonizes phorbol esters (PMA) but not IL-4-induced CD20 down-regulation.	Staurosporine	121-134	interleukin 4	Homo sapiens	0-4
1373168-7	1992	IL-4 most likely utilizes a protein kinase C-independent signal transduction pathway to modify CD20 molecule inasmuch as staurosporine, an inhibitor of protein kinase C, antagonizes phorbol esters (PMA) but not IL-4-induced CD20 down-regulation.	Staurosporine	121-134	membrane spanning 4-domains A1	Homo sapiens	95-99
1547736-4	1992	The inhibitory effect of PMA (5 nM) was reversed by preincubation of the cells with staurosporine (ST; 50 nM), an inhibitor of PKC.	Staurosporine	84-97	protein kinase C, gamma	Rattus norvegicus	127-130
1547736-4	1992	The inhibitory effect of PMA (5 nM) was reversed by preincubation of the cells with staurosporine (ST; 50 nM), an inhibitor of PKC.	Staurosporine	99-101	protein kinase C, gamma	Rattus norvegicus	127-130
1560050-3	1992	We report here that nanomolar concentrations of STAR strongly potentiated (20- to 30-fold) the production of IL-2 or IL-4, when EL 4-6.1 cells were induced by IL-1 alpha (or IL-1 beta) alone.	Staurosporine	48-52	interleukin 2	Mus musculus	109-113
1560050-3	1992	We report here that nanomolar concentrations of STAR strongly potentiated (20- to 30-fold) the production of IL-2 or IL-4, when EL 4-6.1 cells were induced by IL-1 alpha (or IL-1 beta) alone.	Staurosporine	48-52	interleukin 4	Mus musculus	117-121
1560050-3	1992	We report here that nanomolar concentrations of STAR strongly potentiated (20- to 30-fold) the production of IL-2 or IL-4, when EL 4-6.1 cells were induced by IL-1 alpha (or IL-1 beta) alone.	Staurosporine	48-52	interleukin 1 alpha	Mus musculus	159-169
1560050-3	1992	We report here that nanomolar concentrations of STAR strongly potentiated (20- to 30-fold) the production of IL-2 or IL-4, when EL 4-6.1 cells were induced by IL-1 alpha (or IL-1 beta) alone.	Staurosporine	48-52	interleukin 1 beta	Mus musculus	174-183
1613078-4	1992	In maxillary process mesenchyme, which formed little cartilage matrix under control culture conditions, staurosporine treatment stimulated extensive cartilage nodule formation, promoted a 5.4-fold rise in matrix GAG accumulation, and increased expression of both type II collagen and cartilage proteoglycan mRNA.	Staurosporine	104-117	collagen type II alpha 1 chain	Gallus gallus	263-279
1613078-5	1992	Moreover, staurosporine treatment initiated chondrocyte differentiation and induced the expression of type II collagen and cartilage proteoglycan gene transcripts in hyoid arch mesenchyme, which exhibited no spontaneous chondrogenesis in control cultures.	Staurosporine	10-23	collagen type II alpha 1 chain	Gallus gallus	102-118
1548459-6	1992	NF-H increased in the perikarya of cells treated with DAG and 4-O-methyl-TPA, in processes and to varying degrees in perikarya of TPA- and 12-deoxy-13-tetradecanoyl-beta-phorbol-treated cells, but much more in the processes than in the perikarya of staurosporine-differentiated cells.	Staurosporine	249-262	neurofilament heavy chain	Homo sapiens	0-4
1548459-6	1992	NF-H increased in the perikarya of cells treated with DAG and 4-O-methyl-TPA, in processes and to varying degrees in perikarya of TPA- and 12-deoxy-13-tetradecanoyl-beta-phorbol-treated cells, but much more in the processes than in the perikarya of staurosporine-differentiated cells.	Staurosporine	249-262	plasminogen activator, tissue type	Homo sapiens	73-76
1548459-7	1992	These findings and additional differences between the differentiation induced by TPA (a PKC activator) and staurosporine (a PKC inhibitor), including distinct morphology of the cell body and processes and time of appearance of the morphological phenotype, suggest that activators and inhibitors of PKC induce differentiation of SH-SY5Y cells by different mechanisms, and that the five-membered/seven-membered terpene ring region present in TPA must be intact for the induction of morphological differentiation.	Staurosporine	107-120	plasminogen activator, tissue type	Homo sapiens	440-443
1312672-7	1992	In addition, staurosporine completely inhibited CYP1A1 mRNA induction by TCDD.	Staurosporine	13-26	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	48-54
1609122-4	1992	PKC inhibitors, staurosporine and sphingosine, abolished phorbol myristate acetate (PMA) potentiation of TXA2 production which strongly supports the role of PKC in the synergism.	Staurosporine	16-29	proline rich transmembrane protein 2	Homo sapiens	157-160
1348695-4	1992	Instead, staurosporine inhibited TPA-induced phosphorylation of p80.	Staurosporine	9-22	coilin	Homo sapiens	64-67
1556141-5	1992	Activation of ISGF3 alpha, although insensitive to 2-aminopurine, was completely blocked by 10 nM staurosporine, an inhibitor of protein kinase C. On the other hand, even 500 nM staurosporine did not block the induction of ISGF3 gamma.	Staurosporine	98-111	interferon regulatory factor 9	Homo sapiens	14-19
1556141-5	1992	Activation of ISGF3 alpha, although insensitive to 2-aminopurine, was completely blocked by 10 nM staurosporine, an inhibitor of protein kinase C. On the other hand, even 500 nM staurosporine did not block the induction of ISGF3 gamma.	Staurosporine	98-111	interferon regulatory factor 9	Homo sapiens	223-234
1313426-11	1992	However, while the protein kinase inhibitor staurosporine completely prevented the desensitization caused by TPA, it had only a limited effect on the desensitization caused by TRP42/55.	Staurosporine	44-57	plasminogen activator, tissue type	Homo sapiens	109-112
1371717-7	1992	Staurosporine, a PKC inhibitor, blocked the TPA-mediated repression of the androgenic stimulation of PSA glycoprotein.	Staurosporine	0-13	kallikrein related peptidase 3	Homo sapiens	101-104
1544907-8	1992	In addition, CD31 phosphorylation in platelets was induced by phorbol ester and was blocked by staurosporin, a protein kinase C inhibitor, suggesting that CD31 phosphorylation is mediated by protein kinase C and involves serine and/or threonine residues.	Staurosporine	95-107	platelet and endothelial cell adhesion molecule 1	Homo sapiens	13-17
1544907-8	1992	In addition, CD31 phosphorylation in platelets was induced by phorbol ester and was blocked by staurosporin, a protein kinase C inhibitor, suggesting that CD31 phosphorylation is mediated by protein kinase C and involves serine and/or threonine residues.	Staurosporine	95-107	platelet and endothelial cell adhesion molecule 1	Homo sapiens	155-159
1540395-8	1992	Staurosporine, a potent PKC inhibitor, at concentrations that inhibited PKC-induced phosphorylation of histone-1, augmented both alpha-thrombin- and NaF-induced production of inositol phosphates but markedly inhibited alpha-thrombin-, NaF-, and A23187-induced PGI2 synthesis.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	149-152
1540395-8	1992	Staurosporine, a potent PKC inhibitor, at concentrations that inhibited PKC-induced phosphorylation of histone-1, augmented both alpha-thrombin- and NaF-induced production of inositol phosphates but markedly inhibited alpha-thrombin-, NaF-, and A23187-induced PGI2 synthesis.	Staurosporine	0-13	C-X-C motif chemokine ligand 8	Homo sapiens	235-238
1547524-0	1992	Staurosporine, a potent protein kinase C inhibitor, augments phorbol ester-caused ornithine decarboxylase induction in mouse epidermis.	Staurosporine	0-13	ornithine decarboxylase, structural 1	Mus musculus	82-105
1547524-2	1992	When mice were topically pretreated with staurosporine, a most potent protein kinase C inhibitor, 6-84 h prior to TPA treatment, TPA-caused ODC induction was markedly enhanced.	Staurosporine	41-54	ornithine decarboxylase, structural 1	Mus musculus	140-143
1547524-3	1992	The enhancement of TPA-caused ODC induction by staurosporine was most pronounced when the time interval between staurosporine and TPA treatment was 36 h. Staurosporine elicited this enhancing effect in a dose-related manner.	Staurosporine	47-60	ornithine decarboxylase, structural 1	Mus musculus	30-33
1547524-3	1992	The enhancement of TPA-caused ODC induction by staurosporine was most pronounced when the time interval between staurosporine and TPA treatment was 36 h. Staurosporine elicited this enhancing effect in a dose-related manner.	Staurosporine	112-125	ornithine decarboxylase, structural 1	Mus musculus	30-33
1547524-3	1992	The enhancement of TPA-caused ODC induction by staurosporine was most pronounced when the time interval between staurosporine and TPA treatment was 36 h. Staurosporine elicited this enhancing effect in a dose-related manner.	Staurosporine	154-167	ornithine decarboxylase, structural 1	Mus musculus	30-33
1547524-4	1992	Staurosporine by itself also induced epidermal ODC activity.	Staurosporine	0-13	ornithine decarboxylase, structural 1	Mus musculus	47-50
1547524-6	1992	Although staurosporine markedly augmented TPA-caused ODC induction, staurosporine-caused ODC induction was not augmented by this compound.	Staurosporine	9-22	ornithine decarboxylase, structural 1	Mus musculus	53-56
1547524-6	1992	Although staurosporine markedly augmented TPA-caused ODC induction, staurosporine-caused ODC induction was not augmented by this compound.	Staurosporine	68-81	ornithine decarboxylase, structural 1	Mus musculus	89-92
1547524-8	1992	These results indicate that the enhancement of ODC induction by staurosporine is specific for the induction caused by TPA and that this enhancing effect is not related to the protein kinase C inhibitory action of staurosporine.	Staurosporine	64-77	ornithine decarboxylase, structural 1	Mus musculus	47-50
1547524-10	1992	Staurosporine-caused ODC induction was also inhibited by indomethacin but the inhibition was not reversed by PGE2, indicating that the mechanism of staurosporine-caused ODC induction is different from that of TPA.	Staurosporine	0-13	ornithine decarboxylase, structural 1	Mus musculus	21-24
1547524-10	1992	Staurosporine-caused ODC induction was also inhibited by indomethacin but the inhibition was not reversed by PGE2, indicating that the mechanism of staurosporine-caused ODC induction is different from that of TPA.	Staurosporine	0-13	ornithine decarboxylase, structural 1	Mus musculus	169-172
1547524-10	1992	Staurosporine-caused ODC induction was also inhibited by indomethacin but the inhibition was not reversed by PGE2, indicating that the mechanism of staurosporine-caused ODC induction is different from that of TPA.	Staurosporine	148-161	ornithine decarboxylase, structural 1	Mus musculus	21-24
1547524-10	1992	Staurosporine-caused ODC induction was also inhibited by indomethacin but the inhibition was not reversed by PGE2, indicating that the mechanism of staurosporine-caused ODC induction is different from that of TPA.	Staurosporine	148-161	ornithine decarboxylase, structural 1	Mus musculus	169-172
1616823-5	1992	The hPKC alpha overexpressing cells had an altered, "transformed-like" morphology, which was reversed by staurosporine, an increased growth rate and a higher saturation density.	Staurosporine	105-118	protein kinase C alpha	Homo sapiens	4-14
1541284-8	1992	However, staurosporine (200 nM), an inhibitor of protein kinase C totally abolished the priming effect of GM-CSF after stimulation with ionomycin.	Staurosporine	9-22	colony stimulating factor 2	Homo sapiens	106-112
1379205-7	1992	The contractions caused by ET-1 were significantly reduced by the protein kinase C (PKC) inhibitor, staurosporine (1 and 10 nM).	Staurosporine	100-113	endothelin 1	Bos taurus	27-31
1314657-3	1992	Concentrations of 10-100 nM staurosporine and K252A inhibit NGF-dependent tyrosine phosphorylation in PC12 cells and inhibit trk oncogene-dependent tyrosine phosphorylation in trk-transformed NIH3T3 (trk-3T3 cells).	Staurosporine	28-41	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	125-128
1314657-3	1992	Concentrations of 10-100 nM staurosporine and K252A inhibit NGF-dependent tyrosine phosphorylation in PC12 cells and inhibit trk oncogene-dependent tyrosine phosphorylation in trk-transformed NIH3T3 (trk-3T3 cells).	Staurosporine	28-41	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	176-179
1314657-3	1992	Concentrations of 10-100 nM staurosporine and K252A inhibit NGF-dependent tyrosine phosphorylation in PC12 cells and inhibit trk oncogene-dependent tyrosine phosphorylation in trk-transformed NIH3T3 (trk-3T3 cells).	Staurosporine	28-41	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	176-179
1314657-5	1992	NGF-stimulated tyrosine phosphorylation of the pp140c-trk NGF receptor and tyrosine phosphorylation of pp70trk are also inhibited by similar concentrations of staurosporine and K252A, whereas tyrosine phosphorylation of the EGF receptor, insulin receptor, and v-src is not affected.	Staurosporine	159-172	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	54-57
1314657-5	1992	NGF-stimulated tyrosine phosphorylation of the pp140c-trk NGF receptor and tyrosine phosphorylation of pp70trk are also inhibited by similar concentrations of staurosporine and K252A, whereas tyrosine phosphorylation of the EGF receptor, insulin receptor, and v-src is not affected.	Staurosporine	159-172	epidermal growth factor like 1	Rattus norvegicus	224-227
1314657-5	1992	NGF-stimulated tyrosine phosphorylation of the pp140c-trk NGF receptor and tyrosine phosphorylation of pp70trk are also inhibited by similar concentrations of staurosporine and K252A, whereas tyrosine phosphorylation of the EGF receptor, insulin receptor, and v-src is not affected.	Staurosporine	159-172	insulin receptor	Rattus norvegicus	238-254
1314657-7	1992	Incubation of trk-3T3 cells with 10 nM staurosporine causes rounded transformed cells to revert to a normal flattened phenotype, whereas src-transformed cells are unaffected by this agent.	Staurosporine	39-52	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	14-17
1314657-8	1992	These data suggest that staurosporine and K252A specifically inhibit the trk tyrosine kinase activity through a direct mechanism, probably accounting for the attenuation by these agents of the cellular actions of NGF.	Staurosporine	24-37	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	73-76
1542698-4	1992	We show that the maturation signal from oncogenic p21 microinjected into Xenopus oocytes is completely blocked by the relatively specific PKC inhibitor CGP 41251, a staurosporine analogue that selectively inhibits PKC, but not by an inactive analogue of staurosporine, CGP 42700.	Staurosporine	165-178	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	50-53
1541903-5	1992	We have also demonstrated that the induction of MGCs by anti-class II MHC antibody and phorbol ester requires protein kinase C activity, because MGC formation was totally inhibited by the protein kinase C inhibitors staurosporine and H-7.	Staurosporine	216-229	major histocompatibility complex, class I, C	Homo sapiens	70-73
1381000-5	1992	Meanwhile, the increase of histidine decarboxylase was abolished by inhibitors of protein kinase C; staurosporine was the strongest, K-252a of moderate activity and H-7, the weakest, having IC50 values of 0.8 nM, 100 nM and 11.5 microM, respectively.	Staurosporine	100-113	histidine decarboxylase	Rattus norvegicus	27-50
1542698-4	1992	We show that the maturation signal from oncogenic p21 microinjected into Xenopus oocytes is completely blocked by the relatively specific PKC inhibitor CGP 41251, a staurosporine analogue that selectively inhibits PKC, but not by an inactive analogue of staurosporine, CGP 42700.	Staurosporine	254-267	cyclin-dependent kinase inhibitor 1A L homeolog	Xenopus laevis	50-53
1543755-7	1992	Thrombin induced the translocation of protein kinase C from the cytosol to the membrane, and a protein kinase C inhibitor, staurosporine, completely inhibited the thrombin-induced translocation of Gi2 alpha.	Staurosporine	123-136	coagulation factor II	Mus musculus	163-171
1543755-10	1992	The thrombin- and TPA-induced potentiation of the ability of the cytosol to release Gi2 alpha was completely abolished by staurosporine.	Staurosporine	122-135	coagulation factor II	Mus musculus	4-12
1539618-8	1992	The inhibition by PMA of GM-CSF binding to its receptors and its phosphorylated effects is partially prevented by the protein kinase C inhibitor 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine and, to a greater extent, by staurosporine.	Staurosporine	221-234	colony stimulating factor 2	Homo sapiens	25-31
1531037-3	1992	We also investigated whether staurosporine, a general inhibitor of protein kinases, influences gp91-phox, p47-phox, and Fc gamma R-I gene expression in PMN treated with or without IFN-gamma.	Staurosporine	29-42	Fc gamma receptor Ia	Homo sapiens	120-132
1311191-4	1992	Staurosporine increased tyrosinase activity and amount of TRP and caused morphological changes with the formation of numerous dendrites, regardless of the presence of dbcAMP.	Staurosporine	0-13	tyrosinase	Homo sapiens	24-34
1311191-6	1992	The effects of staurosporine on tyrosinase activity and TRP content were completely inhibited by PMA, but PMA did not significantly affect the staurosporine-induced morphological changes.	Staurosporine	15-28	tyrosinase	Homo sapiens	32-42
1322299-9	1992	Treatments with staurosporine, a protein kinase inhibitor, or okadaic acid, a protein phosphatase inhibitor, either alone or in combination with TPA, indicated that the abundance of the dephosphorylated form of Cx43 in MDCK cells was due to low kinase activity.	Staurosporine	16-29	gap junction protein alpha 1	Canis lupus familiaris	211-215
1740241-10	1992	Two protein kinase C inhibitors, H-7 and staurosporine, partly diminished the expression of c-fos, whereas a third, 2-aminopurine, which has a broader spectrum of inhibiting protein kinases, almost completely abolished it.	Staurosporine	41-54	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
1735599-5	1992	Responses of rings to endothelin-1 were profoundly reduced in Ca(2+)-free medium, but less inhibition was obtained after incubation with nicardipine (up to 1 microM) and/or nickel (up to 0.5 mM), phorbol (up to 0.3 microM), staurosporine (up to 10 nM), or cromakalim (3 microM).	Staurosporine	224-237	endothelin 1	Rattus norvegicus	22-34
1586701-3	1992	The results show that PKC inhibitors, such as sphingosine (SPH), staurosporine (STP) and H-7, blocked IL-5-induced IgA synthesis; the protein kinase A inhibitor HA-1004 and the inhibitor of calcium/calmodulin dependent protein kinase W-7 had no effect on IgA secretion induced by IL-5.	Staurosporine	65-78	interleukin 5	Mus musculus	102-106
1586701-3	1992	The results show that PKC inhibitors, such as sphingosine (SPH), staurosporine (STP) and H-7, blocked IL-5-induced IgA synthesis; the protein kinase A inhibitor HA-1004 and the inhibitor of calcium/calmodulin dependent protein kinase W-7 had no effect on IgA secretion induced by IL-5.	Staurosporine	65-78	interleukin 5	Mus musculus	280-284
1586701-3	1992	The results show that PKC inhibitors, such as sphingosine (SPH), staurosporine (STP) and H-7, blocked IL-5-induced IgA synthesis; the protein kinase A inhibitor HA-1004 and the inhibitor of calcium/calmodulin dependent protein kinase W-7 had no effect on IgA secretion induced by IL-5.	Staurosporine	80-83	interleukin 5	Mus musculus	102-106
1729394-6	1992	This latter activity was relatively resistant to staurosporine inhibition and phorbol ester treatment, but it phosphorylated the exogenous PKC substrates, histone 1 and the epidermal growth factor receptor peptide KTRLRR.	Staurosporine	49-62	protein kinase C, gamma	Rattus norvegicus	139-142
1347198-7	1992	In contrast, the kinase inhibitor staurosporine dose dependently inhibited ICAM-1 expression triggered by PMA (IC50 67 +/- 4 nM) but, at similar concentrations, did not inhibit ICAM-1 expression induced by the other inflammatory stimuli.	Staurosporine	34-47	intercellular adhesion molecule 1	Homo sapiens	75-81
1729394-6	1992	This latter activity was relatively resistant to staurosporine inhibition and phorbol ester treatment, but it phosphorylated the exogenous PKC substrates, histone 1 and the epidermal growth factor receptor peptide KTRLRR.	Staurosporine	49-62	epidermal growth factor receptor	Rattus norvegicus	173-205
1310864-5	1992	The protein kinase inhibitors staurosporine and H-7 blocked thrombin-induced retraction.	Staurosporine	30-43	coagulation factor II	Mus musculus	60-68
1538715-5	1992	Previous studies indicated that staurosporine inhibits PKC by binding its catalytic domain.	Staurosporine	32-45	protein kinase C, alpha	Rattus norvegicus	55-58
1538715-6	1992	In this study, we define the kinetics of inhibition by staurosporine of a catalytic fragment of rat brain PKC-gamma and of a catalytic fragment generated from a rat brain PKC-alpha/PKC-beta mixture.	Staurosporine	55-68	protein kinase C, gamma	Rattus norvegicus	106-115
1538715-6	1992	In this study, we define the kinetics of inhibition by staurosporine of a catalytic fragment of rat brain PKC-gamma and of a catalytic fragment generated from a rat brain PKC-alpha/PKC-beta mixture.	Staurosporine	55-68	protein kinase C, beta	Rattus norvegicus	181-189
1538715-7	1992	Our kinetic results provide evidence that staurosporine inhibits PKC by binding to a site of the catalytic domain other than the ATP substrate and protein substrate binding sites.	Staurosporine	42-55	protein kinase C, alpha	Rattus norvegicus	65-68
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	0-13	protein kinase C, alpha	Rattus norvegicus	98-101
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	0-13	protein kinase C, alpha	Rattus norvegicus	145-154
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	0-13	protein kinase C, beta	Rattus norvegicus	156-164
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	170-179
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	0-13	protein kinase C, beta	Rattus norvegicus	219-227
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	232-241
1538690-0	1992	Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1.	Staurosporine	22-35	protein kinase C	Saccharomyces cerevisiae S288C	71-75
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	111-124	protein kinase C, alpha	Rattus norvegicus	98-101
1538690-0	1992	Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1.	Staurosporine	22-35	protein kinase C	Saccharomyces cerevisiae S288C	106-110
1538690-0	1992	Characterization of a staurosporine- and temperature-sensitive mutant, stt1, of Saccharomyces cerevisiae: STT1 is allelic to PKC1.	Staurosporine	22-35	protein kinase C	Saccharomyces cerevisiae S288C	125-129
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	111-124	protein kinase C, alpha	Rattus norvegicus	145-154
1538690-5	1992	The STT1 gene conferred resistance to staurosporine on wild-type cells, when present on a high copy number plasmid.	Staurosporine	38-51	protein kinase C	Saccharomyces cerevisiae S288C	4-8
1538690-6	1992	STT1/stt1::HIS3 diploid cells were more sensitive to staurosporine than STT1/STT1 diploid cells.	Staurosporine	53-66	protein kinase C	Saccharomyces cerevisiae S288C	0-4
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	111-124	protein kinase C, beta	Rattus norvegicus	156-164
1538690-6	1992	STT1/stt1::HIS3 diploid cells were more sensitive to staurosporine than STT1/STT1 diploid cells.	Staurosporine	53-66	protein kinase C	Saccharomyces cerevisiae S288C	5-9
1538690-8	1992	These results suggest that a protein kinase (the STT1 gene product) is one of the essential targets of staurosporine in yeast cells.	Staurosporine	103-116	protein kinase C	Saccharomyces cerevisiae S288C	49-53
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	111-124	protein kinase C, gamma	Rattus norvegicus	170-179
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	111-124	protein kinase C, beta	Rattus norvegicus	219-227
1538715-8	1992	Staurosporine inhibition appears to entail binding at a conserved site in the catalytic domain of PKC, because staurosporine inhibited rat brain PKC-alpha, PKC-beta, and PKC-gamma, as well as the catalytic fragments of PKC-beta and PKC-gamma, with similar protencies.	Staurosporine	111-124	protein kinase C, gamma	Rattus norvegicus	232-241
1538715-9	1992	The kinetics of inhibition of the catalytic fragment of PKC-gamma were uncompetitive with respect to histone III-S, providing evidence that the binding of histone III-S at the active site of the catalytic fragment precedes the binding of staurosporine to the enzyme.	Staurosporine	238-251	protein kinase C, gamma	Rattus norvegicus	56-65
1538715-10	1992	Taken in the context of previous mechanistic studies of PKC-catalyzed histone III-S phosphorylation, these results provide evidence that staurosporine binds to a complex of PKC, MgATP, and histone III-S, thereby forming a complex that cannot break down to products.	Staurosporine	137-150	protein kinase C, alpha	Rattus norvegicus	56-59
1538715-11	1992	In addition, the inhibitory kinetics observed when the ATP concentration was varied provided evidence that staurosporine reduces the affinity of MgATP for the catalytic fragment of PKC-gamma.	Staurosporine	107-120	protein kinase C, gamma	Rattus norvegicus	181-190
1538715-12	1992	Thus, the kinetics of inhibition of the catalytic fragment of PKC-gamma by staurosporine provide evidence that staurosporine inhibits PKC by a mixed mechanism.	Staurosporine	75-88	protein kinase C, gamma	Rattus norvegicus	62-71
1538715-12	1992	Thus, the kinetics of inhibition of the catalytic fragment of PKC-gamma by staurosporine provide evidence that staurosporine inhibits PKC by a mixed mechanism.	Staurosporine	75-88	protein kinase C, alpha	Rattus norvegicus	62-65
1538715-12	1992	Thus, the kinetics of inhibition of the catalytic fragment of PKC-gamma by staurosporine provide evidence that staurosporine inhibits PKC by a mixed mechanism.	Staurosporine	111-124	protein kinase C, gamma	Rattus norvegicus	62-71
1538715-12	1992	Thus, the kinetics of inhibition of the catalytic fragment of PKC-gamma by staurosporine provide evidence that staurosporine inhibits PKC by a mixed mechanism.	Staurosporine	111-124	protein kinase C, alpha	Rattus norvegicus	62-65
1310599-11	1992	In all these studies thrombin (0.05-0.2 unit/ml) elicited characteristic responses, and thrombin-induced secretion was inhibited by staurosporine, PGI2 and GDP[S].	Staurosporine	132-145	coagulation factor II, thrombin	Homo sapiens	88-96
1730737-1	1992	HL60 and EL4 cells incubated with tumor necrosis factor-alpha (TNF-alpha) plus staurosporin, a potent inhibitor of protein kinases, showed at least 2-fold increased levels of nuclear factor-kappa B (NF-kappa B) activity compared with TNF-alpha alone both during rapid NF-kappa B activation from the cytosolic pool and protein synthesis-dependent NF-kappa B activation.	Staurosporine	79-91	tumor necrosis factor	Mus musculus	34-61
1730737-1	1992	HL60 and EL4 cells incubated with tumor necrosis factor-alpha (TNF-alpha) plus staurosporin, a potent inhibitor of protein kinases, showed at least 2-fold increased levels of nuclear factor-kappa B (NF-kappa B) activity compared with TNF-alpha alone both during rapid NF-kappa B activation from the cytosolic pool and protein synthesis-dependent NF-kappa B activation.	Staurosporine	79-91	tumor necrosis factor	Mus musculus	63-72
1730737-1	1992	HL60 and EL4 cells incubated with tumor necrosis factor-alpha (TNF-alpha) plus staurosporin, a potent inhibitor of protein kinases, showed at least 2-fold increased levels of nuclear factor-kappa B (NF-kappa B) activity compared with TNF-alpha alone both during rapid NF-kappa B activation from the cytosolic pool and protein synthesis-dependent NF-kappa B activation.	Staurosporine	79-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	175-197
1730737-1	1992	HL60 and EL4 cells incubated with tumor necrosis factor-alpha (TNF-alpha) plus staurosporin, a potent inhibitor of protein kinases, showed at least 2-fold increased levels of nuclear factor-kappa B (NF-kappa B) activity compared with TNF-alpha alone both during rapid NF-kappa B activation from the cytosolic pool and protein synthesis-dependent NF-kappa B activation.	Staurosporine	79-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	199-209
1730737-1	1992	HL60 and EL4 cells incubated with tumor necrosis factor-alpha (TNF-alpha) plus staurosporin, a potent inhibitor of protein kinases, showed at least 2-fold increased levels of nuclear factor-kappa B (NF-kappa B) activity compared with TNF-alpha alone both during rapid NF-kappa B activation from the cytosolic pool and protein synthesis-dependent NF-kappa B activation.	Staurosporine	79-91	tumor necrosis factor	Mus musculus	234-243
1730737-1	1992	HL60 and EL4 cells incubated with tumor necrosis factor-alpha (TNF-alpha) plus staurosporin, a potent inhibitor of protein kinases, showed at least 2-fold increased levels of nuclear factor-kappa B (NF-kappa B) activity compared with TNF-alpha alone both during rapid NF-kappa B activation from the cytosolic pool and protein synthesis-dependent NF-kappa B activation.	Staurosporine	79-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	268-278
1730737-1	1992	HL60 and EL4 cells incubated with tumor necrosis factor-alpha (TNF-alpha) plus staurosporin, a potent inhibitor of protein kinases, showed at least 2-fold increased levels of nuclear factor-kappa B (NF-kappa B) activity compared with TNF-alpha alone both during rapid NF-kappa B activation from the cytosolic pool and protein synthesis-dependent NF-kappa B activation.	Staurosporine	79-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	268-278
1730737-2	1992	NF-kappa B activation by phorbol 12-myristate 13-acetate (PMA) and interleukin-1 was inhibited by staurosporin.	Staurosporine	98-110	nuclear factor kappa B subunit 1	Homo sapiens	0-10
1730737-3	1992	Staurosporin treatment hardly affected the TNF-alpha-induced increase in mRNA for the p51 subunit of NF-kappa B but interfered with any phorbol ester (PMA)-induced increase in p51 mRNA.	Staurosporine	0-12	tumor protein p63	Homo sapiens	86-89
1730737-3	1992	Staurosporin treatment hardly affected the TNF-alpha-induced increase in mRNA for the p51 subunit of NF-kappa B but interfered with any phorbol ester (PMA)-induced increase in p51 mRNA.	Staurosporine	0-12	nuclear factor kappa B subunit 1	Homo sapiens	101-111
1730737-3	1992	Staurosporin treatment hardly affected the TNF-alpha-induced increase in mRNA for the p51 subunit of NF-kappa B but interfered with any phorbol ester (PMA)-induced increase in p51 mRNA.	Staurosporine	0-12	tumor protein p63	Homo sapiens	176-179
1730737-4	1992	Thus, induction of NF-kappa B and p51 mRNA by TNF-alpha was not mediated by a staurosporin-sensitive factor, but NF-kappa B activation by TNF-alpha was even reduced by action of a staurosporin-sensitive factor.	Staurosporine	180-192	nuclear factor kappa B subunit 1	Homo sapiens	19-29
1730737-4	1992	Thus, induction of NF-kappa B and p51 mRNA by TNF-alpha was not mediated by a staurosporin-sensitive factor, but NF-kappa B activation by TNF-alpha was even reduced by action of a staurosporin-sensitive factor.	Staurosporine	180-192	tumor protein p63	Homo sapiens	34-37
1730737-4	1992	Thus, induction of NF-kappa B and p51 mRNA by TNF-alpha was not mediated by a staurosporin-sensitive factor, but NF-kappa B activation by TNF-alpha was even reduced by action of a staurosporin-sensitive factor.	Staurosporine	180-192	tumor necrosis factor	Homo sapiens	46-55
1730737-4	1992	Thus, induction of NF-kappa B and p51 mRNA by TNF-alpha was not mediated by a staurosporin-sensitive factor, but NF-kappa B activation by TNF-alpha was even reduced by action of a staurosporin-sensitive factor.	Staurosporine	180-192	nuclear factor kappa B subunit 1	Homo sapiens	113-123
1730737-4	1992	Thus, induction of NF-kappa B and p51 mRNA by TNF-alpha was not mediated by a staurosporin-sensitive factor, but NF-kappa B activation by TNF-alpha was even reduced by action of a staurosporin-sensitive factor.	Staurosporine	180-192	tumor necrosis factor	Homo sapiens	138-147
1730737-5	1992	Decreased levels of phosphorylation of TNF-R alpha (TNF receptor type alpha) after staurosporin-treatment correlated with increased induction of NF-kappa B by TNF-alpha.	Staurosporine	83-95	TNF receptor superfamily member 1A	Homo sapiens	39-44
1730737-5	1992	Decreased levels of phosphorylation of TNF-R alpha (TNF receptor type alpha) after staurosporin-treatment correlated with increased induction of NF-kappa B by TNF-alpha.	Staurosporine	83-95	nuclear factor kappa B subunit 1	Homo sapiens	145-155
1730737-5	1992	Decreased levels of phosphorylation of TNF-R alpha (TNF receptor type alpha) after staurosporin-treatment correlated with increased induction of NF-kappa B by TNF-alpha.	Staurosporine	83-95	tumor necrosis factor	Homo sapiens	159-168
1730238-3	1992	Furthermore, the level of CDw50 phosphorylation induced by tumor promoter agents is decreased by the protein kinase C inhibitors staurosporine and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine.	Staurosporine	129-142	intercellular adhesion molecule 3	Homo sapiens	26-31
1310050-5	1992	Protein kinase C inhibitors, such as staurosporin, H-7 and K255a, suppressed the increase in HDC activity induced by TPA with or without dexamethasone.	Staurosporine	37-49	histidine decarboxylase	Mus musculus	93-96
1730679-7	1992	A variety of agents were tested for their ability to inhibit p56lck, with zinc ions (I50 approximately 1.7 mM) and staurosporine (I50 approximately 500 nM) proving the most potent.	Staurosporine	115-128	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	61-67
1340298-3	1992	PKC inhibitors, H7 and staurosporine inhibited E. histolytica (37 and 75%) and PMA (46 and 100%)-induced mucin secretion, whereas in response to Ca2+ ionophore mucin secretion was augmented (56 and 17%).	Staurosporine	23-36	LOC100508689	Homo sapiens	105-110
1340298-3	1992	PKC inhibitors, H7 and staurosporine inhibited E. histolytica (37 and 75%) and PMA (46 and 100%)-induced mucin secretion, whereas in response to Ca2+ ionophore mucin secretion was augmented (56 and 17%).	Staurosporine	23-36	LOC100508689	Homo sapiens	160-165
1309427-5	1992	Similar to PAF, alpha-thrombin-exposed sites rapidly closed after addition of the protein kinase C inhibitor staurosporine (1 mumol/L) or dibutyryl cyclic adenosine monophosphate (250 mumol/L).	Staurosporine	109-122	coagulation factor II, thrombin	Homo sapiens	22-30
12106301-9	1992	Their action was antagonized by staurosporin, probably via its effect on protein kinase A.	Staurosporine	32-44	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	73-89
12106302-4	1992	In the presence of staurosporin, protein kinase C activation by phorbol esters and protein kinase A activation by 8-bromo-cyclic adenosine monophosphate were blocked.	Staurosporine	19-31	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	83-99
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	matrix metallopeptidase 9	Homo sapiens	28-33
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	TIMP metallopeptidase inhibitor 1	Homo sapiens	38-44
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	proline rich transmembrane protein 2	Homo sapiens	100-116
1284126-11	1992	TPA-mediated stimulation of MMP-9 and TIMP-1 activity was blocked by staurosporine, an inhibitor of protein kinase C (PKC).	Staurosporine	69-82	proline rich transmembrane protein 2	Homo sapiens	118-121
1326499-4	1992	Staurosporine and H-7, inhibitors acting on the catalytic domain of PKC, prevented the growth reduction of P3HR-1 cells harboring EBV genomes and the induction of viral DNA synthesis by TPA.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	68-71
1507640-0	1992	Staurosporine prevents the impairment of endothelium-dependent relaxation by oxidized-LDL in pig coronary arteries.	Staurosporine	0-13	LDL	Sus scrofa	86-89
1744140-6	1991	We report that two potent protein kinase inhibitors, staurosporine and K-252a, ablated the transcriptional response to IFN alpha treatment.	Staurosporine	53-66	interferon alpha 1	Homo sapiens	119-128
1744140-11	1991	We conclude that a novel, staurosporine/K-252a-sensitive kinase is required for ISGF3 activity and may participate in receptor-mediated signal transduction.	Staurosporine	26-39	interferon regulatory factor 9	Homo sapiens	80-85
1720802-6	1991	Conversely, G-CSF priming was inhibited by staurosporine but not by ST638.	Staurosporine	43-56	colony stimulating factor 3	Homo sapiens	12-17
1962329-4	1991	At 10 nM, staurosporine, an inhibitor of protein kinase C activity, blunted the platelet-induced augmentation of the response to thrombin but did not alter the sensitivity or the maximal contraction to 8-64 mM K+.	Staurosporine	10-23	prothrombin	Oryctolagus cuniculus	129-137
1659231-8	1991	The pHi increase was abolished by 1) blockade of the Na(+)-H+ exchanger by ethyl isopropyl amiloride and 2) inhibition of protein kinase C (PKC) activity via pretreatment with staurosporine or prolonged incubation with 4 beta-phorbol 12-myristate 13-acetate.	Staurosporine	176-189	glucose-6-phosphate isomerase	Homo sapiens	4-7
1814434-11	1991	Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	42-45
1814434-11	1991	Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.	Staurosporine	0-13	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	149-154
1814434-11	1991	Staurosporine, a nonspecific inhibitor of PKC, partially blocked TPA-induced adherence and growth inhibition and concomitantly prevented TPA-induced c-fos and c-jun gene expression.	Staurosporine	0-13	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	159-164
1801783-6	1991	In addition, nonspecific protein kinase inhibitors, staurosporin and H7 attenuated c-jun expression, whereas the analogue of ATP (sangivamycin) did not.	Staurosporine	52-64	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	83-88
1835466-6	1991	Staurosporine, an inhibitor of PKC, partially inhibited the abilities of antigen and A23187 to induce beta-hexosaminidase release but was ineffective when lyso-PC was the secretagogue.	Staurosporine	0-13	O-GlcNAcase	Mus musculus	102-121
1818333-3	1991	Selective PKC inhibitors (H-7 and staurosporine) can block the ability of IFN-alpha to activate the transcription of a distinct set of genes, called the IFN-stimulated genes (ISG), and to protect cells against viral infection.	Staurosporine	34-47	protein kinase C beta	Homo sapiens	10-13
1656971-6	1991	Staurosporine (SS) and H-7 decreased the synthesis of HSP70 and HSP83 but had no effect on HO.	Staurosporine	0-13	heat shock protein family A (Hsp70) member 4	Homo sapiens	54-59
1656971-6	1991	Staurosporine (SS) and H-7 decreased the synthesis of HSP70 and HSP83 but had no effect on HO.	Staurosporine	15-17	heat shock protein family A (Hsp70) member 4	Homo sapiens	54-59
1730873-8	1992	IFN-gamma-induction of ICSBP mRNA is resistant to cycloheximide but sensitive to protein kinase inhibitors (H7, H8, HA-1004, staurosporine) at doses that suggest that protein kinase C is a likely target.	Staurosporine	125-138	interferon gamma	Mus musculus	0-9
1730873-8	1992	IFN-gamma-induction of ICSBP mRNA is resistant to cycloheximide but sensitive to protein kinase inhibitors (H7, H8, HA-1004, staurosporine) at doses that suggest that protein kinase C is a likely target.	Staurosporine	125-138	interferon regulatory factor 8	Mus musculus	23-28
1736894-4	1992	This stimulation was inhibited by low concentrations (50% inhibition at 0.7 nM) of the PKC inhibitor staurosporine.	Staurosporine	101-114	proline rich transmembrane protein 2	Homo sapiens	87-90
1730652-5	1992	PKC inhibitors, 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride and staurosporine, also drastically reduced LAK cell activity.	Staurosporine	83-96	protein kinase C, alpha	Mus musculus	0-3
1730652-5	1992	PKC inhibitors, 1-(5-isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride and staurosporine, also drastically reduced LAK cell activity.	Staurosporine	83-96	alpha-kinase 1	Mus musculus	123-126
1730654-6	1992	Induction was inhibited by H7 and staurosporine but not by HA1004, indicating the involvement of a functional protein kinase C. The Egr-1 message was translated and the cellular Egr-1 protein detected within 60 min of cytokine treatment.	Staurosporine	34-47	early growth response 1	Homo sapiens	132-137
1730654-6	1992	Induction was inhibited by H7 and staurosporine but not by HA1004, indicating the involvement of a functional protein kinase C. The Egr-1 message was translated and the cellular Egr-1 protein detected within 60 min of cytokine treatment.	Staurosporine	34-47	early growth response 1	Homo sapiens	178-183
1309742-4	1992	Forskolin and dbcAMP-dependent expression of FPR and FPR transcript was inhibited by staurosporine.	Staurosporine	85-98	formyl peptide receptor 1	Homo sapiens	45-48
1309742-4	1992	Forskolin and dbcAMP-dependent expression of FPR and FPR transcript was inhibited by staurosporine.	Staurosporine	85-98	formyl peptide receptor 1	Homo sapiens	53-56
1730592-5	1992	Staurosporine also suppresses the TPA-induced down-regulation, possibly indicating that the down-regulation of the MARCKS-related protein is dependent on its phosphorylation by protein kinase C.	Staurosporine	0-13	myristoylated alanine rich protein kinase C substrate	Mus musculus	115-121
1728320-7	1992	Using a series of inhibitors with known specificities and established rank-orders of potency for different kinases, we determined that the c-myc response to Epo was blocked with the following rank order: staurosporine much greater than H7 greater than sangivamycin greater than H8.	Staurosporine	204-217	erythropoietin	Mus musculus	157-160
1384867-3	1992	While potent but nonselective inhibitors such as staurosporine exerted a dose-dependent inhibition of Fc epsilon-receptor-mediated histamine release, staurosporine derivatives with high selectivity for PKC potentiated the IgE-mediated response.	Staurosporine	150-163	immunoglobulin heavy constant epsilon	Homo sapiens	222-225
1325591-3	1992	While the inhibitory effect of H-7 was reversible upon washing of the cells with inhibitor-free medium, the inhibition was maintained in cells treated with staurosporine or trifluoperazine.	Staurosporine	156-169	solute carrier family 9 member A2	Rattus norvegicus	31-34
1360276-10	1992	The induction of MDR1 expression by TPA and DAG was suppressed by staurosporine, a protein kinase inhibitor.	Staurosporine	66-79	ATP binding cassette subfamily B member 1	Homo sapiens	17-21
1934072-3	1991	The expression of HLA-DR molecules induced by IFN-gamma was blocked by the protein kinase C (PKC) inhibitors sphingosine, staurosporine, and H7.	Staurosporine	122-135	interferon gamma	Homo sapiens	46-55
1819689-4	1991	A protein kinase C inhibitor, staurosporine, and an inhibitor of phospholipase A2, p-bromophen-acylbromide, inhibited stimulated PAF formation in both fractions.	Staurosporine	30-43	PCNA clamp associated factor	Rattus norvegicus	129-132
1655906-4	1991	The synthetic diacylglycerol 1-oleoyl-2-acetylglycerol has the same effects as PMA, and the protein kinase inhibitor staurosporine prevents the PMA-mediated inhibition of IFN-alpha/beta expression.	Staurosporine	117-130	interferon alpha 1	Homo sapiens	171-180
1803346-7	1991	In EGF-treated cells, staurosporine and TPA, but not H-7, decreased DNA synthesis.	Staurosporine	22-35	epidermal growth factor	Mus musculus	3-6
1818333-3	1991	Selective PKC inhibitors (H-7 and staurosporine) can block the ability of IFN-alpha to activate the transcription of a distinct set of genes, called the IFN-stimulated genes (ISG), and to protect cells against viral infection.	Staurosporine	34-47	interferon alpha 1	Homo sapiens	74-83
1953649-7	1991	Stimulation of 15-PGDH activity by PMA or DMSO appears to be mediated by protein kinase C activation, since an inactive analogue of PMA failed to induce the effect, and both staurosporine and H-7 blocked the stimulation.	Staurosporine	174-187	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	15-22
1953649-11	1991	Time-dependent inactivation of 15-PGDH within the first 1 h was observed and this inactivation was partially blocked by staurosporine and H-7.	Staurosporine	120-133	15-hydroxyprostaglandin dehydrogenase	Homo sapiens	31-38
1928327-2	1991	Prior exposure to PKC antagonists staurosporine (0.03 microM) and H-7 (10 microM) had relatively little effect on contractions to phorbol 12-myristate 13-acetate (PMA), while contractions to norepinephrine and KCl were greatly inhibited.	Staurosporine	34-47	protein kinase C, gamma	Rattus norvegicus	18-21
1833099-4	1991	The aggregation of PRP by these antibodies was inhibited by prostaglandin E1 (PGE1) or staurosporine (protein kinase C inhibitor), whereas it was only slightly affected by a monoclonal anti-GPIIb/IIIa antibody or Arg-Gly-Asp-Ser.	Staurosporine	87-100	complement component 4 binding protein alpha	Homo sapiens	19-22
1665733-8	1991	Furthermore, staurosporine (100 nM) increased [Ca2+]i when added during the plateau phase of the increase in [Ca2+]i induced by thrombin or bradykinin.	Staurosporine	13-26	coagulation factor II, thrombin	Bos taurus	128-136
1665733-8	1991	Furthermore, staurosporine (100 nM) increased [Ca2+]i when added during the plateau phase of the increase in [Ca2+]i induced by thrombin or bradykinin.	Staurosporine	13-26	kininogen 1	Bos taurus	140-150
1655395-9	1991	conversely, application of the PKC inhibitors H7 [1-(5-isoquinolylsulfonyl)2-methyl-piperazine] and staurosporine or desensitization of PKC by long exposure of the cells to TPA abolished the cAMP response to TPA as well as that to AII.	Staurosporine	100-113	protein kinase C, gamma	Rattus norvegicus	31-34
1917946-8	1991	H7 and another PKC inhibitor, staurosporine, inhibited IFN-gamma-induced class II gene expression.	Staurosporine	30-43	interferon gamma	Homo sapiens	55-64
1655031-6	1991	It is concluded that: (a) phosphorylation of the Na+/H+ exchanger is the common origin of the diverse effects of PMA, DHG, okadaic acid and staurosporine, (b) Na+/H+ exchange properties are tightly regulated by phosphorylation and dephosphorylation, and (c) the exchanger plays a major role in pHi regulation in platelets.	Staurosporine	140-153	glucose-6-phosphate isomerase	Homo sapiens	294-297
1656952-2	1991	Inhibition of PKC by staurosporine and the selective PKC inhibitor CGP 41251 significantly reduced Epo formation.	Staurosporine	21-34	protein kinase C alpha	Homo sapiens	14-17
1908468-4	1991	We show that the protein kinase inhibitor staurosporine, but not various other kinase inhibitors, specifically blocked the NGF induction of transin.	Staurosporine	42-55	nerve growth factor	Rattus norvegicus	123-126
1832772-5	1991	The selective PKC inhibitor staurosporine blocked the transcriptional activation of IFN-alpha-stimulated genes, the cytoplasmic accumulation of mRNAs for these genes, and the induction of antiviral activity by IFN-alpha against vesicular stomatitis virus in IFN-sensitive cells.	Staurosporine	28-41	proline rich transmembrane protein 2	Homo sapiens	14-17
1832772-5	1991	The selective PKC inhibitor staurosporine blocked the transcriptional activation of IFN-alpha-stimulated genes, the cytoplasmic accumulation of mRNAs for these genes, and the induction of antiviral activity by IFN-alpha against vesicular stomatitis virus in IFN-sensitive cells.	Staurosporine	28-41	interferon alpha 1	Homo sapiens	84-93
1832772-5	1991	The selective PKC inhibitor staurosporine blocked the transcriptional activation of IFN-alpha-stimulated genes, the cytoplasmic accumulation of mRNAs for these genes, and the induction of antiviral activity by IFN-alpha against vesicular stomatitis virus in IFN-sensitive cells.	Staurosporine	28-41	interferon alpha 1	Homo sapiens	210-219
1678684-7	1991	In support of this hypothesis, staurosporine induces ornithine decarboxylase activity, inhibits 125I-labeled epidermal growth factor binding, and induces expression of c-fos mRNA.	Staurosporine	31-44	FBJ osteosarcoma oncogene	Mus musculus	168-173
1651969-10	1991	In contrast, the inhibition caused by monomeric IgG2a, which binds to Fc gamma RI most likely on keratinocytes, or monomeric IgG3, which probably binds to this same Fc gamma RI, is abrogated by staurosporine, an inhibitor of protein kinase C, as well as by W7, a calmodulin antagonist.	Staurosporine	194-207	Fc receptor, IgG, high affinity I	Mus musculus	165-176
1651969-10	1991	In contrast, the inhibition caused by monomeric IgG2a, which binds to Fc gamma RI most likely on keratinocytes, or monomeric IgG3, which probably binds to this same Fc gamma RI, is abrogated by staurosporine, an inhibitor of protein kinase C, as well as by W7, a calmodulin antagonist.	Staurosporine	194-207	immunoglobulin heavy variable V1-9	Mus musculus	48-53
1651969-10	1991	In contrast, the inhibition caused by monomeric IgG2a, which binds to Fc gamma RI most likely on keratinocytes, or monomeric IgG3, which probably binds to this same Fc gamma RI, is abrogated by staurosporine, an inhibitor of protein kinase C, as well as by W7, a calmodulin antagonist.	Staurosporine	194-207	Immunoglobulin heavy constant gamma 3	Mus musculus	125-129
1716311-4	1991	We examined the effect of the PKC inhibitor, staurosporine, on goat anti-human IgE-induced mediator release.	Staurosporine	45-58	proline rich transmembrane protein 2	Homo sapiens	30-33
1716311-4	1991	We examined the effect of the PKC inhibitor, staurosporine, on goat anti-human IgE-induced mediator release.	Staurosporine	45-58	immunoglobulin heavy constant epsilon	Homo sapiens	79-82
1716311-9	1991	Despite using agents which act by different mechanisms, short-term inhibition with staurosporine and long-term treatment with TPA, we obtained consistent results which suggest that PKC is playing a prorelease role in IgE-mediated signaling.	Staurosporine	83-96	proline rich transmembrane protein 2	Homo sapiens	181-184
1659543-9	1991	The protein kinase C (PKC) inhibitors H-7 (0.3-30 microM) and staurosporine (0.75 micrograms/ml) blocked FSH-induced c-fos mRNA expression in cultured granulosa cells while HA 1004, an inhibitor of cGMP- and cAMP-dependent protein kinases at 30 microM had no effect on TPA-induced c-fos expression, and only minimally inhibited FSH-induced c-fos expression.	Staurosporine	62-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-122
1659543-9	1991	The protein kinase C (PKC) inhibitors H-7 (0.3-30 microM) and staurosporine (0.75 micrograms/ml) blocked FSH-induced c-fos mRNA expression in cultured granulosa cells while HA 1004, an inhibitor of cGMP- and cAMP-dependent protein kinases at 30 microM had no effect on TPA-induced c-fos expression, and only minimally inhibited FSH-induced c-fos expression.	Staurosporine	62-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	281-286
1659543-9	1991	The protein kinase C (PKC) inhibitors H-7 (0.3-30 microM) and staurosporine (0.75 micrograms/ml) blocked FSH-induced c-fos mRNA expression in cultured granulosa cells while HA 1004, an inhibitor of cGMP- and cAMP-dependent protein kinases at 30 microM had no effect on TPA-induced c-fos expression, and only minimally inhibited FSH-induced c-fos expression.	Staurosporine	62-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	281-286
1770953-7	1991	Treatment with the potent kinase inhibitor staurosporine in combination with bGH caused a dose-dependent decrease of the bGH response with different sensitivities toward the inhibitor for the different mRNA species, IGF-I being less sensitive.	Staurosporine	43-56	insulin-like growth factor 1	Rattus norvegicus	216-221
1791921-9	1991	Pre-incubation with the protein kinase C (PKC) inhibitor, staurosporine, inhibited 86Rb+ efflux by 66%, suggesting the involvement of PKC activation in ET-mediated 86Rb+ efflux.	Staurosporine	58-71	endothelin 1	Rattus norvegicus	152-154
1874734-1	1991	Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory concentration (IC50) of 10 nM.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	46-62
1874734-1	1991	Staurosporine is the most potent inhibitor of protein kinase C (PKC) described in the literature with a half-maximal inhibitory concentration (IC50) of 10 nM.	Staurosporine	0-13	proline rich transmembrane protein 2	Homo sapiens	64-67
1886766-6	1991	Moreover, efficient activation of the IRF-E by NDV is specifically inhibited by the protein kinase inhibitor, Staurosporin.	Staurosporine	110-122	tripartite motif containing 63	Homo sapiens	38-41
1879563-3	1991	We have shown in a rat fibroblast line that staurosporine is a potent PTK inhibitor capable of clearly discriminating the two types of receptor-stimulated Ca2+ mobilization and, by inference, PLC activations the response triggered by PDGF was completely inhibited, whereas the responses triggered by vasopressin, bombesin and PGF2 alpha were not affected at all.	Staurosporine	44-57	protein tyrosine kinase 2 beta	Homo sapiens	70-73
1879563-3	1991	We have shown in a rat fibroblast line that staurosporine is a potent PTK inhibitor capable of clearly discriminating the two types of receptor-stimulated Ca2+ mobilization and, by inference, PLC activations the response triggered by PDGF was completely inhibited, whereas the responses triggered by vasopressin, bombesin and PGF2 alpha were not affected at all.	Staurosporine	44-57	arginine vasopressin	Rattus norvegicus	300-311
1879563-3	1991	We have shown in a rat fibroblast line that staurosporine is a potent PTK inhibitor capable of clearly discriminating the two types of receptor-stimulated Ca2+ mobilization and, by inference, PLC activations the response triggered by PDGF was completely inhibited, whereas the responses triggered by vasopressin, bombesin and PGF2 alpha were not affected at all.	Staurosporine	44-57	gastrin releasing peptide	Homo sapiens	313-321
1907849-8	1991	Moreover, the induction of c-jun transcripts by ara-C was inhibited by the isoquinolinesulfonamide derivative H7, but not by HA1004, suggesting that this effect is mediated by protein kinase C. Ara-C-induced c-jun expression was also inhibited by staurosporine, another inhibitor of protein kinase C. Taken together, these results indicate that the cellular response to ara-C includes the activation of protein kinase C and that ara-C potentially induces c-jun transcription by a protein kinase C dependent signaling mechanism.	Staurosporine	247-260	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
1650153-8	1991	The mechanism of activation appeared to involve protein kinase C (PKC) since pretreatment of lung LGL with the PKC inhibitors H-7 or staurosporine abrogated the PAF-induced effect.	Staurosporine	133-146	protein kinase C, gamma	Rattus norvegicus	48-64
1650153-8	1991	The mechanism of activation appeared to involve protein kinase C (PKC) since pretreatment of lung LGL with the PKC inhibitors H-7 or staurosporine abrogated the PAF-induced effect.	Staurosporine	133-146	protein kinase C, gamma	Rattus norvegicus	66-69
1650153-8	1991	The mechanism of activation appeared to involve protein kinase C (PKC) since pretreatment of lung LGL with the PKC inhibitors H-7 or staurosporine abrogated the PAF-induced effect.	Staurosporine	133-146	protein kinase C, gamma	Rattus norvegicus	111-114
1650153-8	1991	The mechanism of activation appeared to involve protein kinase C (PKC) since pretreatment of lung LGL with the PKC inhibitors H-7 or staurosporine abrogated the PAF-induced effect.	Staurosporine	133-146	PCNA clamp associated factor	Rattus norvegicus	161-164
1859477-3	1991	Simultaneous addition of the PKC antagonist, staurosporine, blocked the mezerein-induced inhibition of IL-1 activity on both proteoglycan degradation and synthesis in a concentration-related manner.	Staurosporine	45-58	interleukin 1 alpha	Homo sapiens	103-107
1909304-3	1991	Protein kinase C inhibitors (H-7, staurosporine), an intracellular Ca2+ chelator, and an inhibitor of phospholipase C (neomycin), all abolished the agonist-induced endothelin-1 release, whereas the Ca2+ channel blocker nicardipine was ineffective.	Staurosporine	34-47	endothelin 1	Bos taurus	164-176
1657858-5	1991	Three different inhibitors of protein kinase C, phloretin, staurosporine, and dihydrosphingosine, significantly diminish the response to ET-1.	Staurosporine	59-72	endothelin-1	Oryctolagus cuniculus	137-141
1744998-3	1991	Both K-252a (10-200 nM) and staurosporine (1-100 nM) blocked the survival promoting effects of bFGF in a concentration-dependent manner.	Staurosporine	28-41	fibroblast growth factor 2	Rattus norvegicus	95-99
1867641-11	1991	Ara-CTP formation was also increased substantially by other PK-C activators including phorbol dibutyrate and mezerein (10-100 nM); this process was inhibited more than 70% by the PK-C inhibitor H-7 (50 microM), but not by the PK-C inhibitors staurosporine, tamoxifen, and HA1004.	Staurosporine	242-255	proline rich transmembrane protein 2	Homo sapiens	179-183
1867641-11	1991	Ara-CTP formation was also increased substantially by other PK-C activators including phorbol dibutyrate and mezerein (10-100 nM); this process was inhibited more than 70% by the PK-C inhibitor H-7 (50 microM), but not by the PK-C inhibitors staurosporine, tamoxifen, and HA1004.	Staurosporine	242-255	proline rich transmembrane protein 2	Homo sapiens	179-183
2061301-6	1991	Furthermore, the TCR-mediated increase in anti-Tyr(P) antibody-bound PLC activity was inhibited by staurosporine at drug concentrations identical with those required for in vivo inhibition of TCR-dependent phosphoinositide breakdown.	Staurosporine	99-112	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	17-20
1829410-0	1991	T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: evidence for a protein kinase C-independent staurosporine-sensitive step.	Staurosporine	138-151	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	0-15
1829410-6	1991	Anti-TcR mAb-induced internalization was maintained in PKC-depleted cells, but unexpectedly remained sensitive to inhibition by staurosporine.	Staurosporine	128-141	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	5-8
1829410-9	1991	Surprisingly, on PKC-depleted cells, the Fab was internalized more readily than in untreated cells and this internalization was sensitive to inhibition by staurosporine.	Staurosporine	155-168	FA complementation group B	Homo sapiens	41-44
1829410-13	1991	Our results indicate that staurosporine inhibits the receptor internalization induced by anti-TcR mAb by means other than inhibition of PKC, suggesting that other kinases may control a step of this internalization process.	Staurosporine	26-39	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	94-97
1688279-8	1991	The PDBu-induced enhancement of transmitter release was blocked by the PKC inhibitor, staurosporine.	Staurosporine	86-99	protein kinase C epsilon	Homo sapiens	71-74
1830593-5	1991	Moreover, unlike TPA, GM-CSF was still able to down-modulate its receptor in cells where PKC was inhibited by 1-(5-isoquinolonesulphonyl)-2-methylpiperazine (H7) and staurosporine or in cells where PKC was exhausted by prolonged incubation with 1 microM TPA.	Staurosporine	166-179	colony stimulating factor 2	Homo sapiens	22-28
1829356-1	1991	Regulation of p11 and annexin II by nerve growth factor, staurosporine, and epidermal growth factor was examined in PC12 rat adrenal pheochromocytoma cells using immunoblot analysis.	Staurosporine	57-70	S100 calcium binding protein A10	Rattus norvegicus	14-17
1829356-4	1991	Staurosporine, a protein kinase inhibitor that at high concentrations induces neurite formation, was as effective as nerve growth factor in increasing the intracellular levels of p11 and annexin II.	Staurosporine	0-13	S100 calcium binding protein A10	Rattus norvegicus	179-182
1829356-5	1991	Epidermal growth factor was less effective than nerve growth factor and staurosporine, producing only a two-fold increase in p11 and a three-fold increase in annexin II.	Staurosporine	72-85	S100 calcium binding protein A10	Rattus norvegicus	125-128
2059222-3	1991	Evidence is also presented that phagocytosis of C3b/bi and IgG-opsonized yeast particles and associated respiratory burst can take place independently of diglyceride formation and of the activity of this second messenger on protein kinase C. In fact: a) propranolol while completely inhibited the formation of diglyceride mass did not modify either the phagocytosis or respiratory burst; b) these two processes were insensitive to staurosporine.	Staurosporine	431-444	endogenous retrovirus group K member 3	Homo sapiens	48-51
2037585-10	1991	In contrast, two inhibitors of PKC, staurosporin and 1-O-hexadecyl-2-O-methylglycerol, inhibited both BK- and PMA-induced DGc formation at 30 min, leaving the rapid response towards BK unaffected.	Staurosporine	36-48	kininogen 1	Homo sapiens	102-104
2037585-10	1991	In contrast, two inhibitors of PKC, staurosporin and 1-O-hexadecyl-2-O-methylglycerol, inhibited both BK- and PMA-induced DGc formation at 30 min, leaving the rapid response towards BK unaffected.	Staurosporine	36-48	kininogen 1	Homo sapiens	182-184
2037586-12	1991	The protein kinase C (PKC) inhibitors staurosporin and 1-O-hexadecyl-2-O-methylglycerol inhibited BK- and PMA-induced activation of PLD.	Staurosporine	38-50	kininogen 1	Homo sapiens	98-100
2037586-12	1991	The protein kinase C (PKC) inhibitors staurosporin and 1-O-hexadecyl-2-O-methylglycerol inhibited BK- and PMA-induced activation of PLD.	Staurosporine	38-50	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	132-135
1742794-5	1991	The effect of vasopressin was dose-dependent and was suppressed by staurosporine (50 microM)--a potent inhibitor of protein kinase C. Inhibitors of protein kinase C by themselves increased gj.	Staurosporine	67-80	arginine vasopressin	Homo sapiens	14-25
1653945-4	1991	The blocking effect of 4-beta-PDB on GCl was prevented by preincubation of the preparations with the PKC inhibitors, staurosporine (1-5 microM) and tetrahydropapaverolone (50-100 microM).	Staurosporine	117-130	germ cell-less 1, spermatogenesis associated	Rattus norvegicus	37-40
1888011-5	1991	Incubation of PKC with staurosporine inhibits the fluorescence decrease with an IC50 of 2 nM.	Staurosporine	23-36	proline rich transmembrane protein 2	Homo sapiens	14-17
2022640-9	1991	Both the Ha-ras and the bombesin-induced stimulation of the furosemide-sensitive Rb+ transport can be blocked by protein kinase C depletion or the protein kinase C inhibitor staurosporine.	Staurosporine	174-187	Harvey rat sarcoma virus oncogene	Mus musculus	9-15
2022640-9	1991	Both the Ha-ras and the bombesin-induced stimulation of the furosemide-sensitive Rb+ transport can be blocked by protein kinase C depletion or the protein kinase C inhibitor staurosporine.	Staurosporine	174-187	gastrin releasing peptide	Homo sapiens	24-32
2022708-9	1991	PKC involvement was initially evaluated with two PKC inhibitors, H7 and staurosporine.	Staurosporine	72-85	proline rich transmembrane protein 2	Homo sapiens	0-3
2022708-11	1991	With H7, the IC50 for all agents was 5 microM; the IC50 for staurosporine was 2 nM for PMA and oxytocin and 5 nM for EGF.	Staurosporine	60-73	epidermal growth factor	Homo sapiens	117-120
2022708-15	1991	Other enzymes that are inhibited by H7 and staurosporine are implicated in the production of PGE2 caused by EGF.	Staurosporine	43-56	epidermal growth factor	Homo sapiens	108-111
1904235-4	1991	The GH-induced expression of c-fos was completely blocked by the protein kinase inhibitors staurosporine and H7, indicating that the action of GH is mediated by one or several protein kinases.	Staurosporine	91-104	FBJ osteosarcoma oncogene	Mus musculus	29-34
1707932-5	1991	Moreover, the PKC inhibitor staurosporine can block PMA-induced endothelial leukocyte adhesion molecule 1 expression at 4 h, but does not inhibit the actions of TNF.	Staurosporine	28-41	selectin E	Homo sapiens	64-105
1707932-6	1991	At 24 h, staurosporine itself induces intercellular adhesion molecule 1 and class I MHC, and acts additively with TNF.	Staurosporine	9-22	intercellular adhesion molecule 1	Homo sapiens	38-87
1707932-6	1991	At 24 h, staurosporine itself induces intercellular adhesion molecule 1 and class I MHC, and acts additively with TNF.	Staurosporine	9-22	tumor necrosis factor	Homo sapiens	114-117
2033505-4	1991	Moreover, staurosporine (0.1 mg/kg) partially reversed the decrease of choline acetyltransferase activity in the fronto-parietal cortex induced by basal forebrain-lesion.	Staurosporine	10-23	choline O-acetyltransferase	Rattus norvegicus	71-96
1831134-6	1991	When infused together with SRTX-b, ET-1 or TPA, staurosporine significantly inhibited the ANP secretion, coronary vasoconstriction and changes in cardiac function induced by the peptides or phorbol ester.	Staurosporine	48-61	endothelin 1	Rattus norvegicus	35-39
2010809-6	1991	The pseudosubstrate peptide PKC19-36 (2 microM in pipette) and the lipid staurosporine (100 nM in pipette), both inhibitors of PKC, reduced the effects of maximal concentrations of OAG or BK by 55-60%.	Staurosporine	73-86	kininogen 1	Homo sapiens	188-190
1848559-7	1991	Furthermore, the PKC inhibitor staurosporine inhibited phosphorylation of p47-phox, interrupted the redistribution of cytosolic oxidase factors, and blocked PMA-induced generation of superoxide anion.	Staurosporine	31-44	neutrophil cytosolic factor 1	Homo sapiens	74-82
1672314-2	1991	The results show that in HL60 cells isolated for resistance to vincristine the protein kinase inhibitor staurosporine induces a major inhibition in the phosphorylation of P-glycoprotein.	Staurosporine	104-117	ATP binding cassette subfamily B member 1	Homo sapiens	171-185
1672314-3	1991	Further studies show that under the same conditions in which staurosporine inhibits P-glycoprotein phosphorylation there is a concomitant increase in cellular drug accumulation and a major inhibition in drug efflux.	Staurosporine	61-74	ATP binding cassette subfamily B member 1	Homo sapiens	84-98
1650519-2	1991	In this comparative study between H7 and the microbial alkaloid, staurosporine, we found that the former inhibited rat brain PKC and cAMP dependent protein kinase with IC50 values of 18 and 16 microM respectively whereas the latter was a much more potent inhibitor of both kinases with IC50 values of 9.5 nM and 42 nM respectively.	Staurosporine	65-78	protein kinase C, gamma	Rattus norvegicus	125-128
1900839-8	1991	Treatment of U937 cells with inhibitors of protein kinase C including staurosporine 10 nM and H-7 50 microM, or down-regulation of protein kinase C by phorbol ester pretreatment blocks the induction of c-jun by GM-CSF.	Staurosporine	70-83	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	202-207
2005115-7	1991	Dansylcadaverine, chloroquine, and staurosporine blocked the appearance of the 40-kDa complex concurrent with the blockage of internalization of the receptor-bound HBGF-1.	Staurosporine	35-48	fibroblast growth factor 1	Homo sapiens	164-170
1650519-4	1991	In contrast, staurosporine was a potent inhibitor of both phorbol ester induced p47 phosphorylation in platelet (I50 value = 540 nM) and also CD3 and CD4 down-regulation in T cells (I50 values 200 nM and 50 nM respectively).	Staurosporine	13-26	NSFL1 cofactor	Rattus norvegicus	80-83
1650519-4	1991	In contrast, staurosporine was a potent inhibitor of both phorbol ester induced p47 phosphorylation in platelet (I50 value = 540 nM) and also CD3 and CD4 down-regulation in T cells (I50 values 200 nM and 50 nM respectively).	Staurosporine	13-26	Cd4 molecule	Rattus norvegicus	150-153
1650519-5	1991	Staurosporine was also a potent inhibitor of IL-2 induced T cell proliferation I50 value = 9 nM).	Staurosporine	0-13	interleukin 2	Rattus norvegicus	45-49
1705566-7	1991	The PKC inhibitor Staurosporine (Sigma Chemical Co., St. Louis, MO) as well as protease inhibitors can completely prevent G-CSF receptor downmodulation.	Staurosporine	18-31	colony stimulating factor 3 receptor	Homo sapiens	122-136
1900005-5	1991	However, staurosporine significantly (P less than 0.05) inhibited the ability of calcitriol to enhance phorbol myristate acetate (PMA)-induced secretion of PA inhibitor activity, indicating that this priming effect of calcitriol requires expression of PKC.	Staurosporine	9-22	proline rich transmembrane protein 2	Homo sapiens	252-255
2001419-3	1991	Protein kinase C inhibitors, staurosporine and K252a (100 nM) or H-7 (15 micrograms/ml) inhibited ionomycin-stimulation of PLA2 activity by 62, 75 and 80%, respectively.	Staurosporine	29-42	phospholipase A2 group IB	Rattus norvegicus	123-127
1846746-7	1991	Two other PKC inhibitors, stearylamine and staurosporine, also blocked PAF synthesis following A23187 or opsonized zymosan stimulation.	Staurosporine	43-56	proline rich transmembrane protein 2	Homo sapiens	10-13
1671400-6	1991	CD2 up-regulation appeared to be elicited by a protein kinase C-dependent mechanism because it was abrogated by staurosporine, a potent protein kinase C inhibitor.	Staurosporine	112-125	CD2 molecule	Homo sapiens	0-3
1846746-7	1991	Two other PKC inhibitors, stearylamine and staurosporine, also blocked PAF synthesis following A23187 or opsonized zymosan stimulation.	Staurosporine	43-56	PCNA clamp associated factor	Homo sapiens	71-74
1703181-4	1991	The induction of c-myc mRNA by anti-IgM or anti-CD20 is blocked by inhibitors of protein kinase C (PKC) such as staurosporine and by pretreatment of B cells with phorbol esters to reduce cellular PKC levels.	Staurosporine	112-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	17-22
1999477-7	1991	In contrast, the thrombin-induced rise in cytoplasmic pH was insensitive to 50 nM staurosporine and only partially reduced with 100 microM H-7.	Staurosporine	82-95	coagulation factor II, thrombin	Homo sapiens	17-25
1703181-4	1991	The induction of c-myc mRNA by anti-IgM or anti-CD20 is blocked by inhibitors of protein kinase C (PKC) such as staurosporine and by pretreatment of B cells with phorbol esters to reduce cellular PKC levels.	Staurosporine	112-125	keratin 20	Homo sapiens	48-52
1703181-4	1991	The induction of c-myc mRNA by anti-IgM or anti-CD20 is blocked by inhibitors of protein kinase C (PKC) such as staurosporine and by pretreatment of B cells with phorbol esters to reduce cellular PKC levels.	Staurosporine	112-125	proline rich transmembrane protein 2	Homo sapiens	81-97
1703181-4	1991	The induction of c-myc mRNA by anti-IgM or anti-CD20 is blocked by inhibitors of protein kinase C (PKC) such as staurosporine and by pretreatment of B cells with phorbol esters to reduce cellular PKC levels.	Staurosporine	112-125	proline rich transmembrane protein 2	Homo sapiens	99-102
1703413-9	1991	Similarly, staurosporine, a relatively selective inhibitor of protein kinase C, and the phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA) an activator of this enzyme, both have pronounced effects on IgE-mediated histamine release from SMC but were completely inactive with regard to [DArg0-Hyp3-DPhe7]-bradykinin-stimulated release.	Staurosporine	11-24	kininogen 1	Homo sapiens	310-320
1988442-6	1991	The protein kinase C inhibitor, staurosporine, totally blocked these changes but only slightly inhibited the increases in labeled PtdOH promoted by alpha-thrombin.	Staurosporine	32-45	coagulation factor II, thrombin	Homo sapiens	154-162
1988955-9	1991	Increases in DAG and phosphatidylethanol were inhibited by the PKC inhibitors K252a and staurosporine.	Staurosporine	88-101	protein kinase C, beta	Rattus norvegicus	63-66
1702431-0	1991	A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.	Staurosporine	28-41	neurotensin	Rattus norvegicus	83-94
1702431-0	1991	A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.	Staurosporine	28-41	neurotensin	Rattus norvegicus	95-107
1824824-7	1991	The PKC inhibitor staurosporine, at both subtoxic and toxic concentrations as well as at concentrations shown to be inhibitory to PKC, failed to increase drug resistance of parent and resistant MOLT-3 cells and decrease drug resistance of MCF-7/WT and MCF-7/DOXR cells.	Staurosporine	18-31	proline rich transmembrane protein 2	Homo sapiens	4-7
1985891-11	1991	The protein kinase inhibitors staurosporine and H-7 blocked P18 and P80 phosphorylation by thrombin but had no effect on P29 phosphorylation by histamine, thrombin, or DiC8 suggesting distinct pathways leading to the phosphorylation of these different proteins.	Staurosporine	30-43	H3 histone pseudogene 12	Homo sapiens	60-63
1985891-11	1991	The protein kinase inhibitors staurosporine and H-7 blocked P18 and P80 phosphorylation by thrombin but had no effect on P29 phosphorylation by histamine, thrombin, or DiC8 suggesting distinct pathways leading to the phosphorylation of these different proteins.	Staurosporine	30-43	coilin	Homo sapiens	68-71
1985891-11	1991	The protein kinase inhibitors staurosporine and H-7 blocked P18 and P80 phosphorylation by thrombin but had no effect on P29 phosphorylation by histamine, thrombin, or DiC8 suggesting distinct pathways leading to the phosphorylation of these different proteins.	Staurosporine	30-43	coagulation factor II, thrombin	Homo sapiens	91-99
1846528-11	1991	The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion.	Staurosporine	35-48	interleukin 1 beta	Rattus norvegicus	80-89
1846528-11	1991	The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion.	Staurosporine	35-48	tumor necrosis factor	Rattus norvegicus	95-98
1846528-11	1991	The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion.	Staurosporine	35-48	phospholipase A2 group IB	Rattus norvegicus	110-126
1824824-7	1991	The PKC inhibitor staurosporine, at both subtoxic and toxic concentrations as well as at concentrations shown to be inhibitory to PKC, failed to increase drug resistance of parent and resistant MOLT-3 cells and decrease drug resistance of MCF-7/WT and MCF-7/DOXR cells.	Staurosporine	18-31	proline rich transmembrane protein 2	Homo sapiens	130-133
1908694-2	1991	The collagen-induced release of [3H]arachidonic acid and formation of [14C]stearoyl-labelled lysophospholipids was inhibited by prior incubation with staurosporine, as was the formation of 3H-labelled thromboxane B2, thereby suggesting inhibition of the collagen-induced phospholipase A2 activity.	Staurosporine	150-163	phospholipase A2 group IB	Homo sapiens	271-287
1892733-6	1991	IL-1 stimulation of arachidonic acid release was blocked by H-7, H-8 and staurosporine.	Staurosporine	73-86	interleukin 1 alpha	Homo sapiens	0-4
1899230-0	1991	Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.	Staurosporine	46-59	mitogen-activated protein kinase 3	Homo sapiens	147-151
1931482-4	1991	The response to gastrin-releasing peptide is abolished by down-regulation of protein kinase C and attenuated by acute inhibition of protein kinase C using staurosporine.	Staurosporine	155-168	gastrin releasing peptide	Mus musculus	16-41
1655518-12	1991	Staurosporine blocks cell-scattering caused by TPA but not that caused by IL-6 suggesting that IL-6 and TPA elicit similar phenotypic changes in breast cancer cells via different pathways.	Staurosporine	0-13	interleukin 6	Homo sapiens	95-99
1899230-0	1991	Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.	Staurosporine	46-59	microtubule associated protein 2	Homo sapiens	152-156
1899230-0	1991	Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.	Staurosporine	46-59	mitogen-activated serine/threonine-protein kinase KSS1	Saccharomyces cerevisiae S288C	184-188
1720762-5	1991	Staurosporine, a protein kinase C inhibitor, reduces GFAP mRNA expression in a dose-dependent manner; in the presence of PMA the effect is additive.	Staurosporine	0-13	glial fibrillary acidic protein	Homo sapiens	53-57
1899230-5	1991	The spk1+ gene product is a 45-kD protein enriched in the nucleus, and its level increases 10-fold after addition of staurosporine.	Staurosporine	117-130	sphingosine kinase 1	Homo sapiens	4-8
1899230-7	1991	The pap1+ gene is required for spk1(+)-conferred staurosporine resistance.	Staurosporine	49-62	sphingosine kinase 1	Homo sapiens	31-35
1985103-5	1991	A pharmacological inhibitor of protein kinase C (staurosporine) greatly attenuates the rise in microvascular albumin clearance (but not the rise in blood flow) induced by glucose or by MOG.	Staurosporine	49-62	myelin oligodendrocyte glycoprotein	Rattus norvegicus	185-188
1777235-5	1991	On the contrary, the tumour promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and the bradykinin derivative Des-Arg9bradykinin that we have previously shown as mitogens for mesangial cells, fail to trigger DNA synthesis or cell proliferation upon staurosporine treatment or in protein kinase C-depleted cells.	Staurosporine	264-277	kininogen 1	Homo sapiens	103-113
1986986-6	1991	Staurosporine (EC50 = 75 nM) and H7 (EC50 = 2 microM) caused concentration-dependent relaxation of SHR aorta, but only staurosporine produced vasorelaxation at concentrations consistent with the inhibition of PKC or MLCK.	Staurosporine	0-13	myosin light chain kinase	Rattus norvegicus	216-220
1986986-11	1991	In conclusion, the vasorelaxant and antihypertensive actions of staurosporine in SHR are consistent with the inhibition of PKC but could also be equally related to inhibition of MLCK.	Staurosporine	64-77	myosin light chain kinase	Rattus norvegicus	178-182
2001987-4	1991	Adherence of EL-4.IL-2 cells in the presence of PMA could be blocked by the addition of two known inhibitors of PKC, 1-(5-isoquinoline-sulfonyl)-2-methylpiperazine dihydrochloride and staurosporine.	Staurosporine	184-197	epilepsy 4	Mus musculus	13-17
2001987-4	1991	Adherence of EL-4.IL-2 cells in the presence of PMA could be blocked by the addition of two known inhibitors of PKC, 1-(5-isoquinoline-sulfonyl)-2-methylpiperazine dihydrochloride and staurosporine.	Staurosporine	184-197	interleukin 2	Mus musculus	18-22
1988650-2	1991	Staurosporine, a potent, but nonselective, inhibitor of protein kinases, attenuated basal, membrane-bound PKC activity in rat stomach fundus (IC50 = 10 nM).	Staurosporine	0-13	protein kinase C, gamma	Rattus norvegicus	106-109
1898612-5	1991	Enhancement of leukotriene release induced by C5a by agents such as staurosporine and interleukin-3 also produced a [Ca++]i kinetic curve which resembled fmet peptide.	Staurosporine	68-81	complement C5a receptor 1	Homo sapiens	46-49
1988650-9	1991	These results: 1) demonstrate that translocation of PKC occurred in rat stomach fundus in response to some, but not all, contractile agonists; 2) are consistent with the possibility that contraction of rat stomach fundus by carbamylcholine and PDBu may be related to increased membrane-bound PKC activity; and 3) indicate that serotonin-induced contraction, although potently blocked by staurosporine, did not result from PKC translocation in the rat stomach fundus.	Staurosporine	387-400	protein kinase C, gamma	Rattus norvegicus	52-55
1924432-8	1991	In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells.	Staurosporine	33-45	interleukin 6	Homo sapiens	54-58
1924432-8	1991	In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells.	Staurosporine	33-45	interleukin 1 alpha	Homo sapiens	100-104
1924432-8	1991	In line with the effects of PMA, staurosporin induced IL-6 production in monocytes and it inhibited IL-1 driven IL-6 production by endothelial cells.	Staurosporine	33-45	interleukin 6	Homo sapiens	112-116
2268359-5	1990	The enhancement of CRF-stimulated beta-endorphin release by IL-1 was also reduced in AtT-20 cells after depletion of protein kinase C, and after treatment with staurosporine.	Staurosporine	160-173	pro-opiomelanocortin-alpha	Mus musculus	34-48
2268359-5	1990	The enhancement of CRF-stimulated beta-endorphin release by IL-1 was also reduced in AtT-20 cells after depletion of protein kinase C, and after treatment with staurosporine.	Staurosporine	160-173	interleukin 1 complex	Mus musculus	60-64
1979736-6	1990	Inhibitors of the ability of VIP to activate nPKC included somatostatin, 8-bromo-cAMP, peripheral benzodiazepine receptor modulators, and the PKC inhibitors, sphingosine and staurosporine.	Staurosporine	174-187	vasoactive intestinal peptide	Rattus norvegicus	29-32
2147682-5	1990	AUR or staurosporine potentiation of FMLP effects on cytoplasmic free Ca2+ [( Ca2+]i) was attributed to suppression of negative feedback effects of protein kinase C. AUR (5-45 microM) per se induced a slow release of internal Ca2+ stores followed by a delayed influx of extracellular Ca2+.	Staurosporine	7-20	formyl peptide receptor 1	Homo sapiens	37-41
1700995-8	1990	Another structurally distinct PKC antagonist, staurosporine, was also effective inhibiting IFN-alpha-induced Fc gamma R and IFN-gamma-induced Ia Ag expression, providing additional evidence that PKC is important.	Staurosporine	46-59	interferon alpha	Mus musculus	91-100
1700995-8	1990	Another structurally distinct PKC antagonist, staurosporine, was also effective inhibiting IFN-alpha-induced Fc gamma R and IFN-gamma-induced Ia Ag expression, providing additional evidence that PKC is important.	Staurosporine	46-59	interferon gamma	Mus musculus	124-133
2174073-8	1990	Staurosporine and H-7, inhibitors of protein kinase C, blocked the IL-1 induction of stromelysin mRNA.	Staurosporine	0-13	interleukin 1 alpha	Homo sapiens	67-71
2246508-9	1990	Further, the protein kinase C inhibitors H7, sangivamycin, and staurosporin block anti-receptor antibody-induced expression of Egr-1, thus, B cell Ag receptor-linked Egr-1 expression is likely coupled to the protein kinase C component of transmembrane signaling.	Staurosporine	63-75	early growth response 1	Mus musculus	127-132
2246508-9	1990	Further, the protein kinase C inhibitors H7, sangivamycin, and staurosporin block anti-receptor antibody-induced expression of Egr-1, thus, B cell Ag receptor-linked Egr-1 expression is likely coupled to the protein kinase C component of transmembrane signaling.	Staurosporine	63-75	early growth response 1	Mus musculus	166-171
2246518-3	1990	This priming event induces the following changes in signal transduction between the opsonin receptors (in particular the CR3 receptor) and activation of the respiratory burst: 1) an enhanced activation of protein kinase C (PK-C): the initiation of the respiratory burst in untreated eosinophils is not sensitive to PK-C inhibition (via staurosporine) and is not accompanied by accumulation of diglycerides and changes in [Ca2+]i.	Staurosporine	336-349	proline rich transmembrane protein 2	Homo sapiens	205-221
2246518-3	1990	This priming event induces the following changes in signal transduction between the opsonin receptors (in particular the CR3 receptor) and activation of the respiratory burst: 1) an enhanced activation of protein kinase C (PK-C): the initiation of the respiratory burst in untreated eosinophils is not sensitive to PK-C inhibition (via staurosporine) and is not accompanied by accumulation of diglycerides and changes in [Ca2+]i.	Staurosporine	336-349	proline rich transmembrane protein 2	Homo sapiens	223-227
2246518-4	1990	After pretreatment with PAF, the initiation of the response is partly sensitive to inhibition of PK-C (via staurosporine) and is accompanied by accumulation of diglycerides and a fast and sustained increase in [Ca2+]i; and 2) an enhancement of a PK-C-independent initiation of the respiratory burst.	Staurosporine	107-120	PCNA clamp associated factor	Homo sapiens	24-27
2246518-4	1990	After pretreatment with PAF, the initiation of the response is partly sensitive to inhibition of PK-C (via staurosporine) and is accompanied by accumulation of diglycerides and a fast and sustained increase in [Ca2+]i; and 2) an enhancement of a PK-C-independent initiation of the respiratory burst.	Staurosporine	107-120	proline rich transmembrane protein 2	Homo sapiens	97-101
2173705-0	1990	Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine.	Staurosporine	90-103	platelet derived growth factor receptor, beta polypeptide	Mus musculus	31-70
2173705-5	1990	In the present study, we report that staurosporine inhibits ligand-dependent PDGF-R tyrosine kinase activation in cell-free receptor preparations and in intact Swiss 3T3 cells.	Staurosporine	37-50	platelet derived growth factor receptor, beta polypeptide	Mus musculus	77-83
2173705-8	1990	A preferential inhibitory effect of staurosporine on signal generation by the PDGF-R was indicated by findings that epidermal growth factor receptor (EGF-R) tyrosine kinase activity and EGF-dependent phospholipase C in A-431 carcinoma cells were approximately 100-fold less sensitive to this drug.	Staurosporine	36-49	platelet derived growth factor receptor, beta polypeptide	Mus musculus	78-84
2173705-8	1990	A preferential inhibitory effect of staurosporine on signal generation by the PDGF-R was indicated by findings that epidermal growth factor receptor (EGF-R) tyrosine kinase activity and EGF-dependent phospholipase C in A-431 carcinoma cells were approximately 100-fold less sensitive to this drug.	Staurosporine	36-49	epidermal growth factor receptor	Mus musculus	116-148
2173705-8	1990	A preferential inhibitory effect of staurosporine on signal generation by the PDGF-R was indicated by findings that epidermal growth factor receptor (EGF-R) tyrosine kinase activity and EGF-dependent phospholipase C in A-431 carcinoma cells were approximately 100-fold less sensitive to this drug.	Staurosporine	36-49	epidermal growth factor receptor	Mus musculus	150-155
2173705-9	1990	These data indicate that submicromolar concentrations of staurosporine inhibit PDGF-dependent phosphoinositide hydrolysis and Ca2+ mobilization through a proximal inhibitory effect on ligand-induced activation of the PDGF-R tyrosine kinase.	Staurosporine	57-70	platelet derived growth factor receptor, beta polypeptide	Mus musculus	217-223
2244911-5	1990	Staurosporine (STS) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented inflammatory mediator-dependent stimulation of both ICAM-1 expression and PMN adherence by HUVEC (ID50 for STS = 2.7-2.9 microM; for H-7 = 7.6-8.8 microM).	Staurosporine	0-13	intercellular adhesion molecule 1	Homo sapiens	139-145
2244911-5	1990	Staurosporine (STS) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented inflammatory mediator-dependent stimulation of both ICAM-1 expression and PMN adherence by HUVEC (ID50 for STS = 2.7-2.9 microM; for H-7 = 7.6-8.8 microM).	Staurosporine	15-18	intercellular adhesion molecule 1	Homo sapiens	139-145
2123405-1	1990	Staurosporine is a microbial anti-fungal alkaloid having a most potent inhibitory activity on protein kinase C and is recently found as a non-12-O-tetradecanoylphorbol-13-acetate (non-TPA)-type tumor promoter of mouse skin, although tumor promotion induced by a TPA-type tumor promoter teleocidin is suppressed by staurosporine.	Staurosporine	0-13	promotion susceptibility QTL 1	Mus musculus	184-187
2123405-1	1990	Staurosporine is a microbial anti-fungal alkaloid having a most potent inhibitory activity on protein kinase C and is recently found as a non-12-O-tetradecanoylphorbol-13-acetate (non-TPA)-type tumor promoter of mouse skin, although tumor promotion induced by a TPA-type tumor promoter teleocidin is suppressed by staurosporine.	Staurosporine	0-13	promotion susceptibility QTL 1	Mus musculus	262-265
2123405-5	1990	At higher concentrations (100 and 1000 ng/ml), staurosporine inhibited TPA-type tumor promoter (TPA, teleocidin and aplysiatoxin)-induced stimulation of arachidonic acid metabolism probably due to the inhibition of protein kinases.	Staurosporine	47-60	plasminogen activator, tissue type	Rattus norvegicus	71-74
2123405-5	1990	At higher concentrations (100 and 1000 ng/ml), staurosporine inhibited TPA-type tumor promoter (TPA, teleocidin and aplysiatoxin)-induced stimulation of arachidonic acid metabolism probably due to the inhibition of protein kinases.	Staurosporine	47-60	plasminogen activator, tissue type	Rattus norvegicus	96-99
2147939-12	1990	But the protein kinase C inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H7) and staurosporine, reduced this IFN-gamma-induced expression.	Staurosporine	93-106	interferon gamma	Homo sapiens	121-130
2265695-2	1990	The diphosphorylation was significantly decreased by treatment with the protein kinase C inhibitor staurosporine (30 nM, 30 min) from 20.1% of total MLC to 4.5%.	Staurosporine	99-112	modulator of VRAC current 1	Homo sapiens	149-152