PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
24733836-7	2014	We also find that Orai3 mutant V77C is sensitive to block by 2-aminoethyl methanethiosulfonate (MTSEA), but not 2-(trimethylammonium)ethyl methanethiosulfonate (MTSET).	methanethiosulfonate ethylammonium	61-94	ORAI calcium release-activated calcium modulator 3	Homo sapiens	18-23
24733836-7	2014	We also find that Orai3 mutant V77C is sensitive to block by 2-aminoethyl methanethiosulfonate (MTSEA), but not 2-(trimethylammonium)ethyl methanethiosulfonate (MTSET).	methanethiosulfonate ethylammonium	96-101	ORAI calcium release-activated calcium modulator 3	Homo sapiens	18-23
22748056-0	2012	Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hK(v)1.3 channels.	methanethiosulfonate ethylammonium	76-81	potassium voltage-gated channel subfamily A member 3	Homo sapiens	86-94
22748056-4	2012	EXPERIMENTAL APPROACH: The influence of 2-aminoethylmethanethiosulphonate (MTSEA) on currents through wild-type human K(v)1.3 (hK(v)1.3) and three mutant channels, hK(v)1.3_L418C, hK(v)1.3_T419C and hK(v)1.3_I420C, in the closed, open and inactivated states was investigated by the patch-clamp technique.	methanethiosulfonate ethylammonium	75-80	potassium voltage-gated channel subfamily A member 3	Homo sapiens	118-125
22748056-4	2012	EXPERIMENTAL APPROACH: The influence of 2-aminoethylmethanethiosulphonate (MTSEA) on currents through wild-type human K(v)1.3 (hK(v)1.3) and three mutant channels, hK(v)1.3_L418C, hK(v)1.3_T419C and hK(v)1.3_I420C, in the closed, open and inactivated states was investigated by the patch-clamp technique.	methanethiosulfonate ethylammonium	75-80	potassium voltage-gated channel subfamily A member 3	Homo sapiens	127-135
22748056-4	2012	EXPERIMENTAL APPROACH: The influence of 2-aminoethylmethanethiosulphonate (MTSEA) on currents through wild-type human K(v)1.3 (hK(v)1.3) and three mutant channels, hK(v)1.3_L418C, hK(v)1.3_T419C and hK(v)1.3_I420C, in the closed, open and inactivated states was investigated by the patch-clamp technique.	methanethiosulfonate ethylammonium	75-80	potassium voltage-gated channel subfamily A member 3	Homo sapiens	164-172
22748056-4	2012	EXPERIMENTAL APPROACH: The influence of 2-aminoethylmethanethiosulphonate (MTSEA) on currents through wild-type human K(v)1.3 (hK(v)1.3) and three mutant channels, hK(v)1.3_L418C, hK(v)1.3_T419C and hK(v)1.3_I420C, in the closed, open and inactivated states was investigated by the patch-clamp technique.	methanethiosulfonate ethylammonium	75-80	potassium voltage-gated channel subfamily A member 3	Homo sapiens	164-172
22748056-4	2012	EXPERIMENTAL APPROACH: The influence of 2-aminoethylmethanethiosulphonate (MTSEA) on currents through wild-type human K(v)1.3 (hK(v)1.3) and three mutant channels, hK(v)1.3_L418C, hK(v)1.3_T419C and hK(v)1.3_I420C, in the closed, open and inactivated states was investigated by the patch-clamp technique.	methanethiosulfonate ethylammonium	75-80	potassium voltage-gated channel subfamily A member 3	Homo sapiens	164-172
21209359-6	2011	The reduced AE1 R730C-mediated sulfate influx did not exhibit the wild-type pattern of stimulation by acidic extracellular pH (pH(o)) and, unexpectedly, was partially rescued by exposure to sodium 2-sulfonatoethyl methanethiosulfonate (MTSES) but not to 2-aminoethyl methanethiosulfonate hydrobromide (MTSEA) or 2-(trimethylammonium)ethyl methanethiosulfonate bromide (MTSET).	methanethiosulfonate ethylammonium	302-307	solute carrier family 4 member 1 (Diego blood group)S homeolog	Xenopus laevis	12-15
22354836-3	2012	The ability of electrophilic derivatives to interact with hASBT was evaluated by 2-aminoethyl-methanethiosulfonate (MTSEA)-biotin labeling of thiol groups in TM7 cysteine mutants.	methanethiosulfonate ethylammonium	81-114	solute carrier family 10 member 2	Homo sapiens	58-63
22354836-3	2012	The ability of electrophilic derivatives to interact with hASBT was evaluated by 2-aminoethyl-methanethiosulfonate (MTSEA)-biotin labeling of thiol groups in TM7 cysteine mutants.	methanethiosulfonate ethylammonium	116-121	solute carrier family 10 member 2	Homo sapiens	58-63
17704058-11	2007	Glu-322, the residue having the greatest influence on hCNT1 transport function, exhibited uridine-protected inhibition by p-chloromercuriphenyl sulfonate and 2-aminoethyl methanethiosulfonate when converted to cysteine.	methanethiosulfonate ethylammonium	158-191	solute carrier family 28 member 1	Homo sapiens	54-59
17998394-3	2007	In this study, the divalent ions cadmium (Cd(2+)) and barium (Ba(2+)), and 2-aminoethyl methanethiosulfonate (MTSEA) were used to probe three sites in the SK2 channel pore, each intracellular to (on the selectivity filter side of) the region that forms the intracellular activation gate of voltage-gated ion channels.	methanethiosulfonate ethylammonium	75-108	potassium calcium-activated channel subfamily N member 2	Homo sapiens	155-158
17998394-3	2007	In this study, the divalent ions cadmium (Cd(2+)) and barium (Ba(2+)), and 2-aminoethyl methanethiosulfonate (MTSEA) were used to probe three sites in the SK2 channel pore, each intracellular to (on the selectivity filter side of) the region that forms the intracellular activation gate of voltage-gated ion channels.	methanethiosulfonate ethylammonium	110-115	potassium calcium-activated channel subfamily N member 2	Homo sapiens	155-158
20664003-4	2010	To test this hypothesis we have begun to obtain structural information about family B GPCRs, using as a prototype the CRF(1), by determining the ability of sulfhydryl-specific methanethiosulfonate derivatives, such as the methanethiosulfonate-ethylammonium (MTSEA), to react with CRF(1) and thus irreversibly inhibit (125)I-Tyr(0)-sauvagine binding.	methanethiosulfonate ethylammonium	222-256	corticotropin releasing hormone receptor 1	Homo sapiens	118-124
20664003-4	2010	To test this hypothesis we have begun to obtain structural information about family B GPCRs, using as a prototype the CRF(1), by determining the ability of sulfhydryl-specific methanethiosulfonate derivatives, such as the methanethiosulfonate-ethylammonium (MTSEA), to react with CRF(1) and thus irreversibly inhibit (125)I-Tyr(0)-sauvagine binding.	methanethiosulfonate ethylammonium	258-263	corticotropin releasing hormone receptor 1	Homo sapiens	118-124
19053233-4	2008	By incubating HEK293 cells stably transfected with CB2 receptors with the small, charged, hydrophilic, thiol-specific reagent methanethiosulfonate ethylammonium (MTSEA), [(3)H]CP55940 binding was significantly inhibited for six mutant receptors.	methanethiosulfonate ethylammonium	126-160	cannabinoid receptor 2	Homo sapiens	51-54
19053233-4	2008	By incubating HEK293 cells stably transfected with CB2 receptors with the small, charged, hydrophilic, thiol-specific reagent methanethiosulfonate ethylammonium (MTSEA), [(3)H]CP55940 binding was significantly inhibited for six mutant receptors.	methanethiosulfonate ethylammonium	162-167	cannabinoid receptor 2	Homo sapiens	51-54
15970596-3	2005	Here we report that covalent modification of NR1-A652C or the analogous mutation in NR2A, -2B, -2C, or -2D by methanethiosulfonate ethylammonium (MT-SEA) occurs only in the presence of glutamate and glycine, and that modification potentiates recombinant NMDA receptor currents.	methanethiosulfonate ethylammonium	110-144	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	45-48
16092934-4	2005	hNET and the mutants were also resistant to methanethiosulfonate (MTS), ethylammonium (MTSEA) and MTStrimethylammonium (MTSET).	methanethiosulfonate ethylammonium	87-92	solute carrier family 6 member 2	Homo sapiens	0-4
17237762-7	2007	Structurally unrelated cysteine-modifying agents such as iodoacetamide (IA) and (2-aminoethyl)methanethiosulphonate (MTSEA) also bind and activate TRPA1.	methanethiosulfonate ethylammonium	117-122	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	147-152
16674915-1	2006	To examine conformational changes during slow inactivation involving domain 2-segment 6 (D2-S6) of human cardiac Na(+) channel (hNav1.5), we applied the substituted-cysteine accessibility method (SCAM) using methanethiosulfonate ethylammonium (MTSEA).	methanethiosulfonate ethylammonium	244-249	sodium voltage-gated channel alpha subunit 5	Homo sapiens	128-135
15970596-3	2005	Here we report that covalent modification of NR1-A652C or the analogous mutation in NR2A, -2B, -2C, or -2D by methanethiosulfonate ethylammonium (MT-SEA) occurs only in the presence of glutamate and glycine, and that modification potentiates recombinant NMDA receptor currents.	methanethiosulfonate ethylammonium	110-144	glutamate ionotropic receptor NMDA type subunit 2A	Homo sapiens	84-93
15840841-2	2005	By incubating human embryonic kidney 293 cells stably transfected with CB2 receptors and MTS derivatives such as MTS ethylammonium (MTSEA), [(3)H]HU-243 binding was inhibited.	methanethiosulfonate ethylammonium	132-137	cannabinoid receptor 2	Homo sapiens	71-74
15620728-1	2005	We have investigated the effect of the sulfhydryl-reactive reagent, methyl thiosulfonate ethylammonium (MTSEA), on ligand binding to the human melanocortin-4 (MC4) receptor stably expressed in HEK-293 cells.	methanethiosulfonate ethylammonium	104-109	melanocortin 4 receptor	Homo sapiens	143-172
15023054-1	2004	Neurokinin-2 receptor (NK(2)R) binding of [(3)H]-SR48968, a piperidinyl antagonist, is inhibited by methanethiosulfonate ethylammonium (MTSEA) in a time- and concentration-dependent manner.	methanethiosulfonate ethylammonium	100-134	tachykinin receptor 2	Homo sapiens	0-21
15023054-1	2004	Neurokinin-2 receptor (NK(2)R) binding of [(3)H]-SR48968, a piperidinyl antagonist, is inhibited by methanethiosulfonate ethylammonium (MTSEA) in a time- and concentration-dependent manner.	methanethiosulfonate ethylammonium	100-134	tachykinin receptor 2	Homo sapiens	23-29
15023054-1	2004	Neurokinin-2 receptor (NK(2)R) binding of [(3)H]-SR48968, a piperidinyl antagonist, is inhibited by methanethiosulfonate ethylammonium (MTSEA) in a time- and concentration-dependent manner.	methanethiosulfonate ethylammonium	136-141	tachykinin receptor 2	Homo sapiens	0-21
15023054-1	2004	Neurokinin-2 receptor (NK(2)R) binding of [(3)H]-SR48968, a piperidinyl antagonist, is inhibited by methanethiosulfonate ethylammonium (MTSEA) in a time- and concentration-dependent manner.	methanethiosulfonate ethylammonium	136-141	tachykinin receptor 2	Homo sapiens	23-29
12963712-2	2003	Previously we showed that methanethiosulfonate ethylammonium (MTSEA+) covalently modifies the RyR to reduce current amplitudes in a time-dependent and stepwise manner.	methanethiosulfonate ethylammonium	26-60	ryanodine receptor 1	Homo sapiens	94-97
12963712-2	2003	Previously we showed that methanethiosulfonate ethylammonium (MTSEA+) covalently modifies the RyR to reduce current amplitudes in a time-dependent and stepwise manner.	methanethiosulfonate ethylammonium	62-68	ryanodine receptor 1	Homo sapiens	94-97
12040046-6	2002	Parachloromercuribenzoic acid and 2-aminoethyl methanethiosulfonate (MTSEA), which share with ONOO(-) the ability to modify cysteine sulfhydryls, also inhibit hDAT function.	methanethiosulfonate ethylammonium	34-67	solute carrier family 6 member 3	Homo sapiens	159-163
12556450-2	2003	We have identified a highly conserved residue (Ala-483) in the sixth membrane-spanning segment of rat NKCC1 that when mutated to cysteine renders the transporter sensitive to inhibition by the sulfhydryl reagents 2-aminoethyl methanethiosulfonate (MTSEA) and 2-(trimethylammonium)ethyl methanethiosulfonate (MTSET).	methanethiosulfonate ethylammonium	213-246	solute carrier family 12 member 2	Rattus norvegicus	102-107
12556450-2	2003	We have identified a highly conserved residue (Ala-483) in the sixth membrane-spanning segment of rat NKCC1 that when mutated to cysteine renders the transporter sensitive to inhibition by the sulfhydryl reagents 2-aminoethyl methanethiosulfonate (MTSEA) and 2-(trimethylammonium)ethyl methanethiosulfonate (MTSET).	methanethiosulfonate ethylammonium	248-253	solute carrier family 12 member 2	Rattus norvegicus	102-107
12040046-6	2002	Parachloromercuribenzoic acid and 2-aminoethyl methanethiosulfonate (MTSEA), which share with ONOO(-) the ability to modify cysteine sulfhydryls, also inhibit hDAT function.	methanethiosulfonate ethylammonium	69-74	solute carrier family 6 member 3	Homo sapiens	159-163
9521769-1	1998	The oxidative regeneration pathways of two three-disulfide mutants of bovine pancreatic ribonuclease A (RNase A) missing the 65-72 disulfide bond, [C65S,C72S] and [C65A,C72A], have been studied by using oxidized dithiothreitol (DTTox) as an oxidizing agent and 2-aminoethylmethanethiosulfonate (AEMTS) as a thiol-blocking agent at 25 degrees C and pH 8.0.	methanethiosulfonate ethylammonium	261-293	ribonuclease pancreatic	Bos taurus	104-111
11134012-1	2001	Membrane permeable N-ethylmaleimide (NEM) and (2-aminoethyl)methanethiosulfonatehydrobromide (MTSEA) inhibited the rat brain Na(+)-Ca(2+) exchanger RBE-2 (NCX1.5) expressed in HEK 293 cells in a dose dependent manner.	methanethiosulfonate ethylammonium	94-99	calcium voltage-gated channel subunit alpha1 E	Rattus norvegicus	148-153
11134012-1	2001	Membrane permeable N-ethylmaleimide (NEM) and (2-aminoethyl)methanethiosulfonatehydrobromide (MTSEA) inhibited the rat brain Na(+)-Ca(2+) exchanger RBE-2 (NCX1.5) expressed in HEK 293 cells in a dose dependent manner.	methanethiosulfonate ethylammonium	94-99	solute carrier family 8 member A1	Rattus norvegicus	155-159
10716733-5	2000	Sens-myc contained a reactive cysteine at position 172, which reacted with both (2-aminoethyl)methanethiosulfonate and N-biotinylaminoethyl methanethiosulfonate on the surface of intact cells.	methanethiosulfonate ethylammonium	80-114	potassium channel tetramerization domain containing 1	Homo sapiens	0-4
10716733-8	2000	In cells co-expressing mixtures of Sens-myc and Res-FLAG, the amount of inactivation by (2-aminoethyl)methanethiosulfonate was less than expected if the two forms were independent.	methanethiosulfonate ethylammonium	88-122	potassium channel tetramerization domain containing 1	Homo sapiens	35-39
10636852-6	2000	Thus, inward translocation of substrates may involve structural rearrangement of hDAT, which likely exposes Cys-342 to reaction with MTSEA, and Cys-342 may be located on a part of the transporter associated with cytoplasmic gating.	methanethiosulfonate ethylammonium	133-138	solute carrier family 6 member 3	Homo sapiens	81-85
10608286-1	1999	In order to study the subunit composition of 5-HT3 receptors (5-HT3R), we report that (2-aminoethyl)methanethiosulfonate (MTSEA) can enhance the function of both nicotinic ACh receptors (nAChRs) comprised of alpha4/beta2 subunits, and heteromeric channels assembled from serotonin 5-HT3R and alpha4 nAChR subunits.	methanethiosulfonate ethylammonium	86-120	5-hydroxytryptamine receptor 3A	Homo sapiens	45-60
10608286-1	1999	In order to study the subunit composition of 5-HT3 receptors (5-HT3R), we report that (2-aminoethyl)methanethiosulfonate (MTSEA) can enhance the function of both nicotinic ACh receptors (nAChRs) comprised of alpha4/beta2 subunits, and heteromeric channels assembled from serotonin 5-HT3R and alpha4 nAChR subunits.	methanethiosulfonate ethylammonium	86-120	5-hydroxytryptamine receptor 3A	Homo sapiens	62-68
10608286-1	1999	In order to study the subunit composition of 5-HT3 receptors (5-HT3R), we report that (2-aminoethyl)methanethiosulfonate (MTSEA) can enhance the function of both nicotinic ACh receptors (nAChRs) comprised of alpha4/beta2 subunits, and heteromeric channels assembled from serotonin 5-HT3R and alpha4 nAChR subunits.	methanethiosulfonate ethylammonium	86-120	immunoglobulin binding protein 1	Homo sapiens	208-220
10608286-1	1999	In order to study the subunit composition of 5-HT3 receptors (5-HT3R), we report that (2-aminoethyl)methanethiosulfonate (MTSEA) can enhance the function of both nicotinic ACh receptors (nAChRs) comprised of alpha4/beta2 subunits, and heteromeric channels assembled from serotonin 5-HT3R and alpha4 nAChR subunits.	methanethiosulfonate ethylammonium	86-120	5-hydroxytryptamine receptor 3A	Homo sapiens	281-287
11274446-2	2001	2-Aminoethyl methanethiosulfonate (MTSEA(+)) failed to modify Cd(2+)-insensitive control-Kir6.2 channels, but rapidly and irreversibly modified Kir6.2[L164C] (L164C) channels.	methanethiosulfonate ethylammonium	0-33	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	144-150
10438469-3	1999	Transport by GAT-1 is sensitive to the polar sulfhydryl reagent 2-aminoethyl methanethiosulfonate.	methanethiosulfonate ethylammonium	64-97	solute carrier family 6 member 1	Homo sapiens	13-18
9521769-1	1998	The oxidative regeneration pathways of two three-disulfide mutants of bovine pancreatic ribonuclease A (RNase A) missing the 65-72 disulfide bond, [C65S,C72S] and [C65A,C72A], have been studied by using oxidized dithiothreitol (DTTox) as an oxidizing agent and 2-aminoethylmethanethiosulfonate (AEMTS) as a thiol-blocking agent at 25 degrees C and pH 8.0.	methanethiosulfonate ethylammonium	295-300	ribonuclease pancreatic	Bos taurus	104-111