PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26881414-5	2016	Cyclodextrins with a single stereochemistry at the hydroxy group on the (2-hydroxypropyl)trialkylammonium chloride substituent were often but not always more effective than the corresponding cyclodextrin in which the C-2 position was racemic.	Cyclodextrins	0-13	complement C2	Homo sapiens	217-220
26881414-5	2016	Cyclodextrins with a single stereochemistry at the hydroxy group on the (2-hydroxypropyl)trialkylammonium chloride substituent were often but not always more effective than the corresponding cyclodextrin in which the C-2 position was racemic.	Cyclodextrins	191-203	complement C2	Homo sapiens	217-220
26005860-0	2015	Cyclodextrin mediated delivery of NF-kappaB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro.	Cyclodextrins	0-12	nuclear factor kappa B subunit 1	Homo sapiens	34-43
26577995-1	2016	To improve the water solubility and tumor targeting ability of docetaxel (DTX), and thus enhance the drug"s antitumor efficacy and safety, a novel folate receptor (FR)-targeted cyclodextrin drug delivery vehicle (FA-CD) was successfully synthesized.	Cyclodextrins	177-189	FA complementation group D2	Homo sapiens	213-218
26196533-12	2015	The cyclodextrin.siRNA nanoparticles achieved cellular uptake and knocked down the endogenous GAPDH gene in the 3D model.	Cyclodextrins	4-16	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	94-99
27019682-2	2016	MBP is involved in maltose transport and bacterial chemotaxis; it binds to maltose and maltodextrins comprising alpha(1-4)-glucosidically linked linear glucose polymers and alpha(1-4)-glucosidically linked cyclodextrins.	Cyclodextrins	206-219	myelin basic protein	Homo sapiens	0-3
27319172-8	2016	The comparison study on the enantioseparation of nine flavonoids with the two CSPs demonstrates the higher enantioselectivities of CSP1 over CSP2, because of the different locations of electron-donating (methyl) and withdrawing (chlorine) groups in the phenylcarbamate moieties of CD derivatives.	Cyclodextrins	281-283	regulator of calcineurin 1	Homo sapiens	131-135
27319172-8	2016	The comparison study on the enantioseparation of nine flavonoids with the two CSPs demonstrates the higher enantioselectivities of CSP1 over CSP2, because of the different locations of electron-donating (methyl) and withdrawing (chlorine) groups in the phenylcarbamate moieties of CD derivatives.	Cyclodextrins	281-283	regulator of calcineurin 2	Homo sapiens	141-145
26005860-0	2015	Cyclodextrin mediated delivery of NF-kappaB and SRF siRNA reduces the invasion potential of prostate cancer cells in vitro.	Cyclodextrins	0-12	serum response factor	Homo sapiens	48-51
26005860-4	2015	The aims of this study were to investigate the ability of a non-viral modified cyclodextrin (CD) vector to deliver siRNA to the highly metastatic PC-3 prostate cancer cell line, to quantify the resulting knockdown of the two target genes (RelA and SRF) and to study the effects of the silencing on metastasis.	Cyclodextrins	79-91	RELA proto-oncogene, NF-kB subunit	Homo sapiens	239-243
25990895-2	2015	The submicron, non-porous, cyclodextrin-based chiral stationary phases (sub_mum-CSP2) exhibited excellent chiral recognition of a wide range of analytes including clenbuterol hydrochloride, mexiletine hydrochloride, chlorpheniramine maleate, esmolol hydrochloride, and metoprolol tartrate.	Cyclodextrins	27-39	regulator of calcineurin 2	Homo sapiens	80-84
26252177-0	2015	SHSST-cyclodextrin complex inhibits TGF-beta/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride-induced liver injury.	Cyclodextrins	6-18	transforming growth factor, beta 1	Rattus norvegicus	36-44
26252177-0	2015	SHSST-cyclodextrin complex inhibits TGF-beta/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride-induced liver injury.	Cyclodextrins	6-18	SMAD family member 3	Rattus norvegicus	45-50
26252177-0	2015	SHSST-cyclodextrin complex inhibits TGF-beta/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride-induced liver injury.	Cyclodextrins	6-18	cellular communication network factor 2	Rattus norvegicus	51-55
26298549-6	2015	The derivatives have significant antioxidant capacity and the powerful activity in inhibiting self-induced amyloid-beta aggregation seems to be led by synergistic effects of both cyclodextrin and hydroxyquinoline.	Cyclodextrins	179-191	amyloid beta precursor protein	Homo sapiens	107-119
25541401-1	2015	Photophysical properties of a bioactive flavonol which can be used as a model for polyhydroxylated natural flavonols, 3,6-diHydroxyflavone (3,6-diHF) in cyclodextrins (CDs)/bovine serum albumin (BSA) systems have been studied by absorption and fluorescence spectroscopy.	Cyclodextrins	153-166	albumin	Homo sapiens	180-193
25940848-2	2015	In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-beta-CD-ss-DOX, which has folic acid (FA) molecules at the end of primary hydroxyl groups of beta-CD and a pH-cleavable spacer with an anticancer drug, doxorubicin (DOX), at the end of secondary hydroxyl groups.	Cyclodextrins	30-42	beta-carotene oxygenase 1	Mus musculus	99-106
25940848-2	2015	In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-beta-CD-ss-DOX, which has folic acid (FA) molecules at the end of primary hydroxyl groups of beta-CD and a pH-cleavable spacer with an anticancer drug, doxorubicin (DOX), at the end of secondary hydroxyl groups.	Cyclodextrins	30-42	beta-carotene oxygenase 1	Mus musculus	192-199
25940848-2	2015	In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-beta-CD-ss-DOX, which has folic acid (FA) molecules at the end of primary hydroxyl groups of beta-CD and a pH-cleavable spacer with an anticancer drug, doxorubicin (DOX), at the end of secondary hydroxyl groups.	Cyclodextrins	44-46	beta-carotene oxygenase 1	Mus musculus	99-106
25940848-2	2015	In this study, we developed a cyclodextrin (CD)-based novel carrier-drug conjugate, called per-FOL-beta-CD-ss-DOX, which has folic acid (FA) molecules at the end of primary hydroxyl groups of beta-CD and a pH-cleavable spacer with an anticancer drug, doxorubicin (DOX), at the end of secondary hydroxyl groups.	Cyclodextrins	44-46	beta-carotene oxygenase 1	Mus musculus	192-199
26148430-0	2015	Cyclodextrin-based PNN supramolecular assemblies: a new class of pincer-type ligands for aqueous organometallic catalysis.	Cyclodextrins	0-12	pinin, desmosome associated protein	Homo sapiens	19-22
26148430-5	2015	Contrary to an acyclic glucopyranose-based NN ligand unable to interact with a phosphane ligand, the CD-based PNN ligands stabilized the catalytic species in water by supramolecular means.	Cyclodextrins	101-103	pinin, desmosome associated protein	Homo sapiens	110-113
25987212-2	2015	Insulin is known to promote wound healing, and when complexed with cyclodextrin presents improved solubility, stability and biological activity.	Cyclodextrins	67-79	insulin	Homo sapiens	0-7
26004006-0	2015	Characterization of 9-nitrocamptothecin-in-cyclodextrin-in-liposomes modified with transferrin for the treating of tumor.	Cyclodextrins	43-55	transferrin	Rattus norvegicus	83-94
25799952-6	2015	Abnormal distribution of VEGFR2 and mTOR and inhibition of VEGFR2 and mTOR activities by tamoxifen were significantly reversed by addition of cholesterol-cyclodextrin complex to the culture media of endothelial cells.	Cyclodextrins	154-166	kinase insert domain receptor	Homo sapiens	25-31
25799952-6	2015	Abnormal distribution of VEGFR2 and mTOR and inhibition of VEGFR2 and mTOR activities by tamoxifen were significantly reversed by addition of cholesterol-cyclodextrin complex to the culture media of endothelial cells.	Cyclodextrins	154-166	mechanistic target of rapamycin kinase	Homo sapiens	36-40
25799952-6	2015	Abnormal distribution of VEGFR2 and mTOR and inhibition of VEGFR2 and mTOR activities by tamoxifen were significantly reversed by addition of cholesterol-cyclodextrin complex to the culture media of endothelial cells.	Cyclodextrins	154-166	kinase insert domain receptor	Homo sapiens	59-65
25799952-6	2015	Abnormal distribution of VEGFR2 and mTOR and inhibition of VEGFR2 and mTOR activities by tamoxifen were significantly reversed by addition of cholesterol-cyclodextrin complex to the culture media of endothelial cells.	Cyclodextrins	154-166	mechanistic target of rapamycin kinase	Homo sapiens	70-74
25618374-0	2015	Cyclodextrin functionalized graphene-gold nanoparticle hybrids with strong supramolecular capability for electrochemical thrombin aptasensor.	Cyclodextrins	0-12	coagulation factor II, thrombin	Homo sapiens	121-129
26138603-1	2015	In this work, two cyclodextrin (CD) chiral stationary phases (CSPs) have been developed by clicking per-4-chloro-3-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP1) and per-5-chloro-2-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP2) onto alkynylated silica support.	Cyclodextrins	18-30	regulator of calcineurin 1	Homo sapiens	166-170
26138603-1	2015	In this work, two cyclodextrin (CD) chiral stationary phases (CSPs) have been developed by clicking per-4-chloro-3-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP1) and per-5-chloro-2-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP2) onto alkynylated silica support.	Cyclodextrins	18-30	regulator of calcineurin 2	Homo sapiens	242-246
26138603-1	2015	In this work, two cyclodextrin (CD) chiral stationary phases (CSPs) have been developed by clicking per-4-chloro-3-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP1) and per-5-chloro-2-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP2) onto alkynylated silica support.	Cyclodextrins	32-34	regulator of calcineurin 1	Homo sapiens	166-170
26138603-1	2015	In this work, two cyclodextrin (CD) chiral stationary phases (CSPs) have been developed by clicking per-4-chloro-3-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP1) and per-5-chloro-2-methylphenylcarbamoylated mono-6(A)-azido-beta-CD (CSP2) onto alkynylated silica support.	Cyclodextrins	32-34	regulator of calcineurin 2	Homo sapiens	242-246
26392920-0	2015	Cyclodextrin Alters GABAergic Input to CA1 Pyramidal Cells in Wild-Type But Not in NPC1-Deficient Mice.	Cyclodextrins	0-12	carbonic anhydrase 1	Mus musculus	39-42
25917001-6	2015	When cyclodextrin is added after laser ablation, the relevant peak at 1210 m/z is observed and assigned as C42 H67 O35 FeNa(+) , which corresponds to a cyclodextrin molecule minus three H atoms.	Cyclodextrins	5-17	CDK5 regulatory subunit associated protein 1	Homo sapiens	107-110
25917001-6	2015	When cyclodextrin is added after laser ablation, the relevant peak at 1210 m/z is observed and assigned as C42 H67 O35 FeNa(+) , which corresponds to a cyclodextrin molecule minus three H atoms.	Cyclodextrins	152-164	CDK5 regulatory subunit associated protein 1	Homo sapiens	107-110
25412657-2	2015	Here we present low-resolution crystal structures of the human alpha1beta2gamma1 holo-AMPK complex bound to its allosteric modulators AMP and the glycogen-mimic cyclodextrin, both in the phosphorylated (4.05 A) and non-phosphorylated (4.60 A) state.	Cyclodextrins	161-173	adrenoceptor alpha 1D	Homo sapiens	63-80
25400034-0	2015	Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1: a mouse model of Niemann-Pick type C1 disease.	Cyclodextrins	65-77	NPC intracellular cholesterol transporter 1	Mus musculus	112-116
26204452-0	2015	Inhibition of insulin amyloid fibril formation by cyclodextrins.	Cyclodextrins	50-63	insulin	Homo sapiens	14-21
24726886-0	2014	Therapeutic efficacy of improved alpha-fetoprotein promoter-mediated tBid delivered by folate-PEI600-cyclodextrin nanopolymer vector in hepatocellular carcinoma.	Cyclodextrins	101-113	alpha fetoprotein	Homo sapiens	33-50
25382259-3	2014	Here we disclose a new site-directing rule for a debenzylation reaction on cyclodextrins that solves this problem and allows the unprecedented access to penta- and ultimately hexa-differentiations of such C6 concave cycles.	Cyclodextrins	75-88	hexosaminidase subunit alpha	Homo sapiens	175-179
25350132-9	2014	In addition, we demonstrate that siRNA-induced caveolin-1 down-regulation or disruption by means of ss-cyclodextrin treatment changes ERK1/2 phosphorylation in response to estrogens stimulation.	Cyclodextrins	103-115	caveolin 1	Homo sapiens	47-57
25350132-9	2014	In addition, we demonstrate that siRNA-induced caveolin-1 down-regulation or disruption by means of ss-cyclodextrin treatment changes ERK1/2 phosphorylation in response to estrogens stimulation.	Cyclodextrins	103-115	mitogen-activated protein kinase 3	Homo sapiens	134-140
24854176-0	2014	Antagonists of the P2X7 receptor: mechanism of enantioselective recognition using highly sulfated and sulfobutylether cyclodextrins by capillary electrokinetic chromatography.	Cyclodextrins	118-131	purinergic receptor P2X 7	Homo sapiens	19-32
24910297-7	2014	The PCA biplot analysis showed that retention is governed by the size of the R1 substituent in the case of derivatized cyclofructan and cyclodextrin CSPs, and enantiomeric resolution closely correlated with the size of the R2 group in the case of non-derivatized gamma-cyclodextrin CSP.	Cyclodextrins	136-148	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	149-152
24664998-7	2014	Recent exciting data on the mechanism by which the cholesterol-sequestering agent cyclodextrin can bypass the functions of NPC1 and NPC2 in the LEs/Ls, and mobilize cholesterol from LEs/Ls, will be highlighted.	Cyclodextrins	82-94	NPC intracellular cholesterol transporter 1	Homo sapiens	123-127
24664998-7	2014	Recent exciting data on the mechanism by which the cholesterol-sequestering agent cyclodextrin can bypass the functions of NPC1 and NPC2 in the LEs/Ls, and mobilize cholesterol from LEs/Ls, will be highlighted.	Cyclodextrins	82-94	NPC intracellular cholesterol transporter 2	Homo sapiens	132-136
25551603-0	2014	Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases Fos protein expression in the central nervous system and produce an antihyperalgesic effect in animal models for fibromyalgia.	Cyclodextrins	0-12	FBJ osteosarcoma oncogene	Mus musculus	71-74
25263922-0	2014	Simultaneous removal of Co(II) and 1-naphthol by core-shell structured Fe 3O4@cyclodextrin magnetic nanoparticles.	Cyclodextrins	78-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-30
25283373-0	2014	Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment.	Cyclodextrins	0-12	vascular endothelial growth factor A	Mus musculus	79-113
25283373-4	2014	Here we examined the potential of self-assembled nanogel of cholesterol-bearing cycloamylose with spermine group (CH-CA-Spe) to deliver vascular endothelial growth factor (VEGF)-specific short interfering RNA (siVEGF) into tumor cells.	Cyclodextrins	80-92	vascular endothelial growth factor A	Mus musculus	136-170
25283373-4	2014	Here we examined the potential of self-assembled nanogel of cholesterol-bearing cycloamylose with spermine group (CH-CA-Spe) to deliver vascular endothelial growth factor (VEGF)-specific short interfering RNA (siVEGF) into tumor cells.	Cyclodextrins	80-92	vascular endothelial growth factor A	Mus musculus	172-176
24911220-1	2014	Propylene Glycol-Free melphalan HCL for Injection (PGF-Mel) is a new formulation that incorporates Captisol, a specially modified cyclodextrin, to improve melphalan stability.	Cyclodextrins	130-142	placental growth factor	Homo sapiens	51-54
25282496-3	2014	OBJECTIVE: The aim of the present study was to find the efficacy of cholesterol-loaded cyclodextrin (CLC; 1 mg per 60 million) and sucrose (0.1 and 0.2 M) on freezing of the goat epididymal sperm.	Cyclodextrins	87-99	chloride channel protein 1	Capra hircus	101-107
24486215-0	2014	Star-shaped cyclodextrin-poly(l-lysine) derivative co-delivering docetaxel and MMP-9 siRNA plasmid in cancer therapy.	Cyclodextrins	12-24	matrix metallopeptidase 9	Homo sapiens	79-84
24662198-3	2014	Cyclodextrin (CDX)-mediated cholesterol depletion attenuated cell surface AGTR1 protein expression and ANG-II-induced intracellular Ca(2+) ([Ca(2+)]i) elevation in the cells.	Cyclodextrins	0-12	AGTR1	Sus scrofa	74-79
24662198-3	2014	Cyclodextrin (CDX)-mediated cholesterol depletion attenuated cell surface AGTR1 protein expression and ANG-II-induced intracellular Ca(2+) ([Ca(2+)]i) elevation in the cells.	Cyclodextrins	14-17	AGTR1	Sus scrofa	74-79
24863226-1	2014	This study aimed to develop a new graphene-based layered assembly, named graphene-cyclodextrin-cytochrome c with improved electron transfer rate.	Cyclodextrins	82-94	cytochrome c, somatic	Homo sapiens	95-107
24679828-6	2014	It also suggests that the previously-known optimum general heating rate (about 10 oC/tM, i.e. 10 C per hold-up time) is also the general optimum for temperature-programmed enantioselective GC analyses with cyclodextrins as stationary phases.	Cyclodextrins	206-219	Rho GTPase activating protein 9	Homo sapiens	94-98
24582377-0	2014	Inhibition of hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by a mTOR siRNA-loaded cyclodextrin nanovector.	Cyclodextrins	109-121	mechanistic target of rapamycin kinase	Homo sapiens	91-95
24582377-3	2014	With the aim to construct useful nanomedicines, the mammalian target of rapamycin (mTOR) siRNA was loaded into hybrid nanoparticles based on low molecular weight (Mw) polyethylenimine (PEI) and a pH-responsive cyclodextrin material (Ac-aCD) or poly(lactic-co-glycolic acid) (PLGA).	Cyclodextrins	210-222	mechanistic target of rapamycin kinase	Homo sapiens	52-81
24582377-3	2014	With the aim to construct useful nanomedicines, the mammalian target of rapamycin (mTOR) siRNA was loaded into hybrid nanoparticles based on low molecular weight (Mw) polyethylenimine (PEI) and a pH-responsive cyclodextrin material (Ac-aCD) or poly(lactic-co-glycolic acid) (PLGA).	Cyclodextrins	210-222	mechanistic target of rapamycin kinase	Homo sapiens	83-87
32261517-3	2014	The binding constant KBCC for the host-guest interaction between cyclodextrin (CyD) residues in BCC and Tyr and Phe residues in insulin was 478.7 M-1 in acetate buffer at pH 3.6, which was ca.	Cyclodextrins	65-77	insulin	Homo sapiens	128-135
32261517-3	2014	The binding constant KBCC for the host-guest interaction between cyclodextrin (CyD) residues in BCC and Tyr and Phe residues in insulin was 478.7 M-1 in acetate buffer at pH 3.6, which was ca.	Cyclodextrins	79-82	insulin	Homo sapiens	128-135
24486215-1	2014	A new cyclodextrin derivative (CD-PLLD) consisting of a beta-cyclodextrin core and poly(l-lysine) dendron arms was prepared by the click conjugation of per-6-azido-b-cyclodextrin with propargyl focal point poly(l-lysine) dendron of third generation, and then used for docetaxel (DOC) and the best siRNA plasmid targeting MMP-9 (pMR3) co-delivery.	Cyclodextrins	6-18	matrix metallopeptidase 9	Homo sapiens	321-326
24631813-7	2014	The PCA biplot analysis showed that retention is governed by the size of the R1 substituent in the case of derivatized cyclofructan and cyclodextrin CSPs, and enantiomeric resolution closely correlated with the size of the R2 group in the case of non-derivatized gamma-cyclodextrin CSP.	Cyclodextrins	136-148	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	149-152
25219867-5	2014	The development of different oral insulin nanoformulations in academic research as well as in patents, including the development of nanoparticles, liposomes, nanoemulsions and the use of cyclodextrins deserves special attention.	Cyclodextrins	187-200	insulin	Homo sapiens	34-41
24412309-8	2014	Lowering the abnormal lipid load of the acidic organelles with cyclodextrin is sufficient to correct the autophagic flux and prevents premature death of NPC1-/- neurons under autophagic stress.	Cyclodextrins	63-75	NPC intracellular cholesterol transporter 1	Homo sapiens	153-157
24377457-2	2014	R-alpha lipoic acid cyclodextrin (RALA-CD) complex is a stable form of lipoic acid (LA) and may improve energy expenditure.	Cyclodextrins	20-32	v-ral simian leukemia viral oncogene A (ras related)	Mus musculus	34-38
25219867-6	2014	The future of oral insulin nanoformulations is dependent on strategies utilizing simple technologies that stabilize the raw material, including inclusion within cyclodextrins or inclusion in low weight molecular mass polymers/ oligomers.	Cyclodextrins	161-174	insulin	Homo sapiens	19-26
24016741-7	2013	Transfection efficiency of CD DNA complexes was enhanced after incubation in bile salts but was reduced after incubation in gastric and intestinal fluids and mucin.	Cyclodextrins	27-29	LOC100508689	Homo sapiens	158-163
24094251-0	2013	Fluorescence enhancement upon G-quadruplex folding: synthesis, structure, and biophysical characterization of a dansyl/cyclodextrin-tagged thrombin binding aptamer.	Cyclodextrins	119-131	coagulation factor II, thrombin	Homo sapiens	139-147
24120173-1	2013	A novel cationic cyclodextrin, mono-6(A)-(2-hydroxyethyl-1-ammonium)-6(A)-beta-cyclodextrin chloride (HEtAMCD) has been successfully synthesized and applied as chiral selector in capillary electrophoresis.	Cyclodextrins	17-29	amyloid beta precursor protein	Homo sapiens	71-78
23948640-0	2013	Combined therapy with cyclodextrin/allopregnanolone and miglustat improves motor but not cognitive functions in Niemann-Pick Type C1 mice.	Cyclodextrins	22-34	NPC intracellular cholesterol transporter 1	Mus musculus	112-132
24245248-0	2013	Cyclodextrin-based nanocomplexes for sustained delivery of human growth hormone.	Cyclodextrins	0-12	growth hormone 1	Homo sapiens	65-79
24076403-2	2013	Analysis of the intact enzyme with hydrogen/deuterium exchange mass spectrometry reveals conformational perturbations of AMPK in response to binding of nucleotides, cyclodextrin, and a synthetic small molecule activator, A769662.	Cyclodextrins	165-177	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	121-125
23785710-1	2013	A linear supramolecular ternary polymer was fabricated by iteratively threading cyclodextrin with suberyl dicholine and end-capping with bis-calixarenes, showing desired cholinesterase response.	Cyclodextrins	80-92	butyrylcholinesterase	Homo sapiens	170-184
24038335-3	2013	In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics.	Cyclodextrins	72-84	superoxide dismutase 1	Homo sapiens	222-242
24038335-3	2013	In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics.	Cyclodextrins	72-84	superoxide dismutase 1	Homo sapiens	244-247
23994793-6	2013	To examine the effectiveness of the cyclodextrin complexes in delivering insulin in vivo, we administered different insulin-cyclodextrin complexes to diabetic rats.	Cyclodextrins	36-48	insulin	Homo sapiens	73-80
23994793-6	2013	To examine the effectiveness of the cyclodextrin complexes in delivering insulin in vivo, we administered different insulin-cyclodextrin complexes to diabetic rats.	Cyclodextrins	124-136	insulin	Homo sapiens	116-123
23769303-1	2013	To develop a multifunctional polymeric carrier for gene and drug co-delivery, a new cyclodextrin derivative containing poly(L-lysine) dendrons was prepared by the click conjugation of per-6-azido-beta-cyclodextrin with propargyl focal point poly(L-lysine) dendron of third generation and then characterized by FTIR, (1)H NMR, and GPC analyses.	Cyclodextrins	84-96	glycophorin C (Gerbich blood group)	Homo sapiens	330-333
23500058-11	2013	This data indicates the clinical potential of a local CD-based TNF-alpha siRNA delivery system for the treatment of IBD.	Cyclodextrins	54-56	tumor necrosis factor	Mus musculus	63-72
23712820-0	2013	Supramolecular iron porphyrin/cyclodextrin dimer complex that mimics the functions of hemoglobin and methemoglobin.	Cyclodextrins	30-42	hemoglobin subunit gamma 2	Homo sapiens	101-114
23500058-0	2013	Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system.	Cyclodextrins	80-92	tumor necrosis factor	Mus musculus	18-27
23500058-4	2013	The aim of this study was to investigate the efficacy of an amphiphilic cationic cyclodextrin (CD) vector for effective TNF-alpha siRNA delivery to macrophage cells and to mice with induced acute-colitis.	Cyclodextrins	81-93	tumor necrosis factor	Mus musculus	120-129
23500058-4	2013	The aim of this study was to investigate the efficacy of an amphiphilic cationic cyclodextrin (CD) vector for effective TNF-alpha siRNA delivery to macrophage cells and to mice with induced acute-colitis.	Cyclodextrins	95-97	tumor necrosis factor	Mus musculus	120-129
23500058-6	2013	RAW264.7 cells were transfected with CD.TNF-alpha siRNA, stimulated with lipopolysaccharide (LPS) and TNF-alpha and IL-6 responses were measured by PCR and ELISA.	Cyclodextrins	37-39	tumor necrosis factor	Mus musculus	40-49
23500058-9	2013	RAW264.7 cells transfected with CD.TNF-alpha siRNA and stimulated with LPS displayed a significant reduction in both gene and protein levels of TNF-alpha and IL-6.	Cyclodextrins	32-34	tumor necrosis factor	Mus musculus	35-44
23500058-9	2013	RAW264.7 cells transfected with CD.TNF-alpha siRNA and stimulated with LPS displayed a significant reduction in both gene and protein levels of TNF-alpha and IL-6.	Cyclodextrins	32-34	tumor necrosis factor	Mus musculus	144-153
23500058-9	2013	RAW264.7 cells transfected with CD.TNF-alpha siRNA and stimulated with LPS displayed a significant reduction in both gene and protein levels of TNF-alpha and IL-6.	Cyclodextrins	32-34	interleukin 6	Mus musculus	158-162
23500058-10	2013	CD.TNF-alpha siRNA-treated mice revealed a mild amelioration in clinical signs of colitis, but significant reductions in total colon weight and colonic mRNA expression of TNF-alpha and IL-6 compared to DSS-control mice were detected.	Cyclodextrins	0-2	tumor necrosis factor	Mus musculus	3-12
23733943-6	2013	Treatment of either NPC1-null or NPC2-deficient cells with cyclodextrin was effective in reducing cholesterol storage as well as the endocytic accumulation of sialoglycoproteins, demonstrating a direct link between cholesterol storage and abnormal recycling.	Cyclodextrins	59-71	NPC intracellular cholesterol transporter 1	Homo sapiens	20-24
22834857-3	2013	The degree to which CD increases the apparent aqueous solubility of certain chemicals has been defined as the solubility enhancement factor (SEF).	Cyclodextrins	20-22	transcription factor CP2	Homo sapiens	110-139
23696862-3	2013	Here, we reported that 6-(4-N,N-dimethylaminophenyltelluro)-6-deoxy-beta-cyclodextrin (DTCD), a cyclodextrin-derived diorganyl telluride which has been identified as an excellent inhibitor of thioredoxin reductase (TrxR), could sensitize TRAIL resistant human ovarian cancer cells to undergo apoptosis.	Cyclodextrins	73-85	peroxiredoxin 5	Homo sapiens	192-213
23696862-3	2013	Here, we reported that 6-(4-N,N-dimethylaminophenyltelluro)-6-deoxy-beta-cyclodextrin (DTCD), a cyclodextrin-derived diorganyl telluride which has been identified as an excellent inhibitor of thioredoxin reductase (TrxR), could sensitize TRAIL resistant human ovarian cancer cells to undergo apoptosis.	Cyclodextrins	73-85	peroxiredoxin 5	Homo sapiens	215-219
23696862-3	2013	Here, we reported that 6-(4-N,N-dimethylaminophenyltelluro)-6-deoxy-beta-cyclodextrin (DTCD), a cyclodextrin-derived diorganyl telluride which has been identified as an excellent inhibitor of thioredoxin reductase (TrxR), could sensitize TRAIL resistant human ovarian cancer cells to undergo apoptosis.	Cyclodextrins	73-85	TNF superfamily member 10	Homo sapiens	238-243
22834857-3	2013	The degree to which CD increases the apparent aqueous solubility of certain chemicals has been defined as the solubility enhancement factor (SEF).	Cyclodextrins	20-22	transcription factor CP2	Homo sapiens	141-144
22834857-6	2013	Our results show that SEF values are inversely related to temperature for most examined chemicals, which is consistent with the assertion that the CD-chemical complexes are less stable at higher temperatures.	Cyclodextrins	147-149	transcription factor CP2	Homo sapiens	22-25
22834857-9	2013	As the definition of SEF predicted, linear relationships were found between the SEFs and CD concentrations for all the subject chemicals.	Cyclodextrins	89-91	transcription factor CP2	Homo sapiens	21-24
23347976-2	2013	Environmental studies typically employ a series of cyclodextrin-based gas chromatography columns to separate all environmentally relevant PCB congeners.	Cyclodextrins	51-63	pyruvate carboxylase	Rattus norvegicus	138-141
23279938-3	2013	In this work, new carboxylated cyclodextrin-based nanosponges (Carb-NS) carrying carboxylic groups within their structure were purposely designed as novel Acyclovir carriers.	Cyclodextrins	31-43	syntaxin 8	Homo sapiens	63-67
22909891-0	2012	Chemometrics-guided development of a cyclodextrin-modified micellar electrokinetic chromatography method with head-column field amplified sample stacking for the analysis of 5-lipoxygenase metabolites.	Cyclodextrins	37-49	arachidonate 5-lipoxygenase	Homo sapiens	174-188
23344194-1	2013	The interactions between cyclophosphamide (CYC) and lysozyme (LYZ) in  the presence of different cyclodextrins (CDs) were investigated by UV absorption, fluorescence spectroscopy, circular dichroism (CD), and molecular modeling techniques under imitated physiological conditions.	Cyclodextrins	97-110	lysozyme	Homo sapiens	52-60
23344194-1	2013	The interactions between cyclophosphamide (CYC) and lysozyme (LYZ) in  the presence of different cyclodextrins (CDs) were investigated by UV absorption, fluorescence spectroscopy, circular dichroism (CD), and molecular modeling techniques under imitated physiological conditions.	Cyclodextrins	97-110	lysozyme	Homo sapiens	62-65
23344194-2	2013	The UV absorption results showed the formation of complexes between CYC and LYZ in the presence of different CDs.	Cyclodextrins	109-112	lysozyme	Homo sapiens	76-79
23344194-5	2013	The binding affinities as well as the number of binding sites were obtained from interaction between CYC and LYZ in the presence of different CDs as binary and ternary systems by modified Stern-Volmer plots.	Cyclodextrins	142-145	lysozyme	Homo sapiens	109-112
23344194-6	2013	The Resonance Light Scattering (RLS) technique was utilized to investigate the effect of drug and CDs on conformational changes of LYZ as separate and simultaneous.	Cyclodextrins	98-101	lysozyme	Homo sapiens	131-134
23344194-8	2013	The effect of CYC and cyclodextrins on the conformation of LYZ was analyzed using synchronous fluorescence spectroscopy.	Cyclodextrins	22-35	lysozyme	Homo sapiens	59-62
23344194-9	2013	Our results revealed that the fluorescence quenching of LYZ originated from the Trp and Tyr residues, and demonstrated conformational changes of LYZ with the addition of CYC and CDs.	Cyclodextrins	178-181	lysozyme	Homo sapiens	56-59
23344194-9	2013	Our results revealed that the fluorescence quenching of LYZ originated from the Trp and Tyr residues, and demonstrated conformational changes of LYZ with the addition of CYC and CDs.	Cyclodextrins	178-181	lysozyme	Homo sapiens	145-148
23344194-10	2013	The molecular distances between the donor (LYZ) and acceptor (CYC and CDs) in binary and ternary systems were estimated according to Forster"s theory and showed static quenching for protein with CYC in the presence of CDs.	Cyclodextrins	70-73	lysozyme	Homo sapiens	43-46
23344194-10	2013	The molecular distances between the donor (LYZ) and acceptor (CYC and CDs) in binary and ternary systems were estimated according to Forster"s theory and showed static quenching for protein with CYC in the presence of CDs.	Cyclodextrins	218-221	lysozyme	Homo sapiens	43-46
23239519-4	2013	The experimental infrared spectra are qualitatively similar for the complexes with the four cations investigated, and are consistent with the binding of the cation within the primary face of the cyclodextrin, as predicted by the quantum computations (B3LYP/6-31+G*).	Cyclodextrins	195-207	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	253-256
23344194-0	2013	Investigation on the interaction between cyclophosphamide and lysozyme in the presence of three different kind of cyclodextrins: determination of the binding mechanism by spectroscopic and molecular modeling techniques.	Cyclodextrins	114-127	lysozyme	Homo sapiens	62-70
22747346-3	2012	CHO (Chinese hamster ovary) cells expressing human apoE under a cholesterol-independent promoter incubated with cholesterol-cyclodextrin complexes showed increased levels of cellular free and esterified cholesterol, inhibition of SREBP-2 (sterol-regulatory-element-binding protein 2) processing, and a mild induction of ER stress, indicating significant accumulation of cholesterol in the ER.	Cyclodextrins	124-136	apolipoprotein E	Homo sapiens	51-55
22892156-0	2012	Cyclodextrin mediates rapid changes in lipid balance in Npc1-/- mice without carrying cholesterol through the bloodstream.	Cyclodextrins	0-12	NPC intracellular cholesterol transporter 1	Mus musculus	56-60
22747346-3	2012	CHO (Chinese hamster ovary) cells expressing human apoE under a cholesterol-independent promoter incubated with cholesterol-cyclodextrin complexes showed increased levels of cellular free and esterified cholesterol, inhibition of SREBP-2 (sterol-regulatory-element-binding protein 2) processing, and a mild induction of ER stress, indicating significant accumulation of cholesterol in the ER.	Cyclodextrins	124-136	sterol regulatory element binding transcription factor 2	Homo sapiens	230-237
22747346-3	2012	CHO (Chinese hamster ovary) cells expressing human apoE under a cholesterol-independent promoter incubated with cholesterol-cyclodextrin complexes showed increased levels of cellular free and esterified cholesterol, inhibition of SREBP-2 (sterol-regulatory-element-binding protein 2) processing, and a mild induction of ER stress, indicating significant accumulation of cholesterol in the ER.	Cyclodextrins	124-136	sterol regulatory element binding transcription factor 2	Homo sapiens	239-282
22747346-5	2012	Removal of excess cholesterol by a cyclodextrin vehicle restored apoE secretion, indicating that the transport defect was reversible.	Cyclodextrins	35-47	apolipoprotein E	Homo sapiens	65-69
22429547-1	2012	A novel cationic cyclodextrin, mono-6(A)-(3-methoxypropan-1-ammonium)-6(A)-beta-cyclodextrin chloride, has been developed and used as chiral selector in capillary electrophoresis (CE).	Cyclodextrins	17-29	amyloid beta precursor protein	Homo sapiens	72-79
22687366-0	2012	Intranasal administration of PACAP: uptake by brain and regional brain targeting with cyclodextrins.	Cyclodextrins	86-99	adenylate cyclase activating polypeptide 1	Mus musculus	29-34
22668084-1	2012	In this study, we aimed at specific targeting of polycationic amphiphilic cyclodextrins (paCDs) to HepG2 cells via the asialoglycoprotein receptor (ASGPr).	Cyclodextrins	74-87	asialoglycoprotein receptor 1	Homo sapiens	119-146
22668084-1	2012	In this study, we aimed at specific targeting of polycationic amphiphilic cyclodextrins (paCDs) to HepG2 cells via the asialoglycoprotein receptor (ASGPr).	Cyclodextrins	74-87	asialoglycoprotein receptor 1	Homo sapiens	148-153
22345171-8	2012	Accordingly, cellular cholesterol depletion (cyclodextrin) and silencing of caveolin-1 (small interfering RNA) inhibited IL-1beta-induced activation of p38-MAPK and MK2, as well as IL-1beta-induced tube formation and migration.	Cyclodextrins	45-57	interleukin 1 beta	Mus musculus	121-129
22446788-0	2012	Forster resonance energy transfer between pyrene and bovine serum albumin: effect of the hydrophobic pockets of cyclodextrins.	Cyclodextrins	112-125	albumin	Homo sapiens	60-73
22446788-1	2012	The phenomenon of Forster resonance energy transfer (FRET) between pyrene and bovine serum albumin (BSA) protein in presence of cyclodextrins (CDs) is explored in the present work.	Cyclodextrins	128-141	albumin	Homo sapiens	85-104
22446788-1	2012	The phenomenon of Forster resonance energy transfer (FRET) between pyrene and bovine serum albumin (BSA) protein in presence of cyclodextrins (CDs) is explored in the present work.	Cyclodextrins	143-146	albumin	Homo sapiens	85-104
22446788-3	2012	In this work we revealed that along with pyrene monomer, the side chains of amino acids in BSA can get trapped partly in the hydrophobic cavities of CDs if space permits.	Cyclodextrins	149-152	albumin	Homo sapiens	91-94
22620966-3	2012	Our recent studies revealed that cyclodextrins (CyDs), cyclic oligosaccharides composed of glucose units, might interact with TTR and prevent the protein misfolding.	Cyclodextrins	33-46	transthyretin	Homo sapiens	126-129
22620966-3	2012	Our recent studies revealed that cyclodextrins (CyDs), cyclic oligosaccharides composed of glucose units, might interact with TTR and prevent the protein misfolding.	Cyclodextrins	48-52	transthyretin	Homo sapiens	126-129
22554145-11	2012	We conclude that cyclodextrin monomers and dimers have specific, modulating effects on the Abeta(1-40) aggregation process.	Cyclodextrins	17-29	amyloid beta precursor protein	Homo sapiens	91-96
22345171-8	2012	Accordingly, cellular cholesterol depletion (cyclodextrin) and silencing of caveolin-1 (small interfering RNA) inhibited IL-1beta-induced activation of p38-MAPK and MK2, as well as IL-1beta-induced tube formation and migration.	Cyclodextrins	45-57	mitogen-activated protein kinase 14	Mus musculus	152-155
22238363-7	2012	Strikingly, we find that blocking cholesterol export from lysosomes with progesterone or U18666A or treating cells with low concentrations of cyclodextrin also caused caveolin-1 to accumulate on late endosome/lysosomal membranes.	Cyclodextrins	142-154	caveolin 1	Homo sapiens	167-177
22336243-9	2012	This was supported by the fact that ABCA1 protein was incrementally expressed by J774 macrophages within the first few hours of incubation with cholesterol-loaded J774 macrophages and that cyclodextrin significantly inhibited the capacity of PON1 to modulate cholesterol efflux from macrophages.	Cyclodextrins	189-201	ATP binding cassette subfamily A member 1	Homo sapiens	36-41
22336243-9	2012	This was supported by the fact that ABCA1 protein was incrementally expressed by J774 macrophages within the first few hours of incubation with cholesterol-loaded J774 macrophages and that cyclodextrin significantly inhibited the capacity of PON1 to modulate cholesterol efflux from macrophages.	Cyclodextrins	189-201	paraoxonase 1	Homo sapiens	242-246
22277650-2	2012	Recent studies demonstrate that administration of cyclodextrin (CD) to Npc1(-/-) mice eliminates cholesterol sequestration in LE/L of many tissues, including the brain, delays neurodegeneration, and increases lifespan of the mice.	Cyclodextrins	50-62	NPC intracellular cholesterol transporter 1	Mus musculus	71-75
22277650-2	2012	Recent studies demonstrate that administration of cyclodextrin (CD) to Npc1(-/-) mice eliminates cholesterol sequestration in LE/L of many tissues, including the brain, delays neurodegeneration, and increases lifespan of the mice.	Cyclodextrins	64-66	NPC intracellular cholesterol transporter 1	Mus musculus	71-75
22277650-8	2012	These studies in Npc1(-/-) neurons and astrocytes establish a dose of CD (0.1 mm) that would likely be beneficial in NPC disease.	Cyclodextrins	70-72	NPC intracellular cholesterol transporter 1	Mus musculus	17-21
21902259-2	2011	As compared to native unmodified proteins, the cyclodextrin-modified proteins (lysozyme and RNase A) exhibit significant reduction in aggregation, surface adsorption and increase in thermal stability.	Cyclodextrins	47-59	ribonuclease A family member 1, pancreatic	Homo sapiens	92-99
23123716-7	2012	In addition, combination of PEGylated insulin and modified cyclodextrin, which form pseudorotaxanes, can be applicable for further modification of pharmacokinetic and pharmacodynamic properties of insulin.	Cyclodextrins	59-71	insulin	Homo sapiens	197-204
21565489-3	2011	In this study, we report that seleno-cyclodextrin (2-selenium-bridged beta-cyclodextrin, 2-SeCD), a seleno-organic compound with glutathione peroxidase (GPx)-mimetic activity, sensitises TRAIL-resistant human breast cancer cells and xenograft tumours to undergo apoptosis.	Cyclodextrins	37-49	TNF superfamily member 10	Homo sapiens	187-192
21983822-1	2011	Enantioselective CE with sulfated cyclodextrins as chiral selectors was used to determine the CYP3A4-catalyzed N-demethylation kinetics of ketamine to norketamine and its inhibition in the presence of ketoconazole in vitro.	Cyclodextrins	34-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	94-100
21769947-6	2011	We concluded that resemblance exists of the representative conformations of these four cyclodextrins with the circularized three-turn single helical structure proposed for CD21 from small-angle X-ray scattering, as well as with the representative conformations of CD26.	Cyclodextrins	87-100	complement C3d receptor 2	Homo sapiens	172-176
21769947-6	2011	We concluded that resemblance exists of the representative conformations of these four cyclodextrins with the circularized three-turn single helical structure proposed for CD21 from small-angle X-ray scattering, as well as with the representative conformations of CD26.	Cyclodextrins	87-100	dipeptidyl peptidase 4	Homo sapiens	264-268
21740003-0	2011	Sterol transfer between cyclodextrin and membranes: similar but not identical mechanism to NPC2-mediated cholesterol transfer.	Cyclodextrins	24-36	NPC intracellular cholesterol transporter 2	Mus musculus	91-95
21740003-4	2011	We demonstrate that cholesterol transport from the lysosomal cholesterol-binding protein NPC2 to CD occurs via aqueous diffusional transfer and is very slow; the rate-limiting step appears to be dissociation of cholesterol from NPC2, suggesting that specific interactions between NPC2 and CD do not occur.	Cyclodextrins	97-99	NPC intracellular cholesterol transporter 2	Mus musculus	89-93
21740003-4	2011	We demonstrate that cholesterol transport from the lysosomal cholesterol-binding protein NPC2 to CD occurs via aqueous diffusional transfer and is very slow; the rate-limiting step appears to be dissociation of cholesterol from NPC2, suggesting that specific interactions between NPC2 and CD do not occur.	Cyclodextrins	97-99	NPC intracellular cholesterol transporter 2	Mus musculus	228-232
21740003-4	2011	We demonstrate that cholesterol transport from the lysosomal cholesterol-binding protein NPC2 to CD occurs via aqueous diffusional transfer and is very slow; the rate-limiting step appears to be dissociation of cholesterol from NPC2, suggesting that specific interactions between NPC2 and CD do not occur.	Cyclodextrins	97-99	NPC intracellular cholesterol transporter 2	Mus musculus	228-232
21740003-4	2011	We demonstrate that cholesterol transport from the lysosomal cholesterol-binding protein NPC2 to CD occurs via aqueous diffusional transfer and is very slow; the rate-limiting step appears to be dissociation of cholesterol from NPC2, suggesting that specific interactions between NPC2 and CD do not occur.	Cyclodextrins	289-291	NPC intracellular cholesterol transporter 2	Mus musculus	89-93
21740003-6	2011	Moreover, CD dramatically increases the rate of sterol transfer between membranes, with rates that can approach those mediated by NPC2.	Cyclodextrins	10-12	NPC intracellular cholesterol transporter 2	Mus musculus	130-134
21762915-3	2011	Phagocytosis was found to be enhanced by pravastatin, rosuvastatin and simvastatin and cyclodextrin in J774 macrophages, as cellular cholesterol was reduced and expressions of the cholesterol-related genes were modulated, including an increase of ABCA7 mRNA and decrease of ABCA1 mRNA.	Cyclodextrins	87-99	ATP-binding cassette, sub-family A (ABC1), member 7	Mus musculus	247-252
21762915-3	2011	Phagocytosis was found to be enhanced by pravastatin, rosuvastatin and simvastatin and cyclodextrin in J774 macrophages, as cellular cholesterol was reduced and expressions of the cholesterol-related genes were modulated, including an increase of ABCA7 mRNA and decrease of ABCA1 mRNA.	Cyclodextrins	87-99	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	274-279
21668413-4	2011	Of various branched beta-CyDs, GUG-beta-CyD [6-O-alpha-(4-O-alpha-D-glucuronyl)-D-glucosyl-beta-CyD] showed potent inhibition of TTR amyloid formation.	Cyclodextrins	24-29	transthyretin	Homo sapiens	129-132
21555769-1	2011	We compared the abilities of structurally related cationic cyclodextrins to inhibit Bacillus anthracis lethal toxin and Staphylococcus aureus alpha-hemolysin.	Cyclodextrins	59-72	AT695_RS11870	Staphylococcus aureus	142-157
21668413-0	2011	Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis.	Cyclodextrins	0-12	transthyretin	Homo sapiens	69-82
21668413-0	2011	Cyclodextrin, a novel therapeutic tool for suppressing amyloidogenic transthyretin misfolding in transthyretin-related amyloidosis.	Cyclodextrins	0-12	transthyretin	Homo sapiens	97-110
21668413-4	2011	Of various branched beta-CyDs, GUG-beta-CyD [6-O-alpha-(4-O-alpha-D-glucuronyl)-D-glucosyl-beta-CyD] showed potent inhibition of TTR amyloid formation.	Cyclodextrins	24-28	transthyretin	Homo sapiens	129-132
21161974-0	2011	SERS chiral recognition and quantification of enantiomers through cyclodextrin supramolecular complexation.	Cyclodextrins	66-78	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	0-4
21622863-13	2011	The hypersensitivity to LPS in cells overexpressing GX sPLA(2) was reversed when cellular free cholesterol was normalized using cyclodextrin.	Cyclodextrins	128-140	phospholipase A2, group X	Mus musculus	52-62
21345936-6	2011	Polysulphated cyclodextrins MA-CDPS, HP-CDPS, CE-CDPS and CDPS at 5 microg/ml concentrations, on the other hand, significantly induced aggrecan production and repressed IL-6 release by the chondrocytes in culture.	Cyclodextrins	14-27	interleukin 6	Homo sapiens	169-173
21483943-0	2011	Cyclodextrin-mediated crystallization of acid beta-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues.	Cyclodextrins	0-12	glucosylceramidase beta	Homo sapiens	41-62
21483943-1	2011	Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid beta-glucosidase (beta-glucocerebrosidase, GlcCerase) with amphiphilic bicyclic nojirimycin analogues of the sp(2)-iminosugar type.	Cyclodextrins	0-12	glucosylceramidase beta	Homo sapiens	113-134
21412152-7	2011	Although no effective treatment for NPC disease is currently available, exciting new studies have shown that treatment of NPC-deficient mice with the cholesterol-binding compound, cyclodextrin, reduces the neurodegeneration and markedly extends the life span of Npc1-/- mice, suggesting a potential therapeutic approach for the treatment of individuals with NPC disease.	Cyclodextrins	180-192	NPC intracellular cholesterol transporter 1	Mus musculus	262-266
21161974-1	2011	We introduce here a simple approach in which a cyclodextrin, functionalized with thiols in the narrower rim, is assembled onto the silver surface of a SERS platform composed of polystyrene beads coated with silver nanoparticles.	Cyclodextrins	47-59	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	151-155
21161974-3	2011	Further, selective recognition of each enantiomer and semiquantification of its proportion in a racemic mixture are provided by the analysis of the SERS spectra of the HBZ-cyclodextrin complex, in full agreement with the surface selection rules.	Cyclodextrins	172-184	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	148-152
21463219-7	2011	EXPERT OPINION: This article aims to provide an overview of the multiple gains in incorporating cyclodextrins in poly(anhydride) nanoparticles, including improvement of their bioadhesive capability, the loading of lipophilic drugs and the effect on efflux membrane proteins and cytochrome P450.	Cyclodextrins	96-109	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	278-293
21463219-8	2011	The combination between bioadhesive nanoparticles and P-gp inhibitors without pharmacological activity (i.e., cyclodextrins) may be useful to promote the oral bioavailability of drugs ascribed to Class IV of the BCS.	Cyclodextrins	110-123	phosphoglycolate phosphatase	Homo sapiens	54-58
21289032-4	2011	The transport defect in mutants lacking NPC2 or NPC1, but not in those lacking LAL, was reversed by cyclodextrin (CD), and the ED50 values for this reversal varied from ~40 mg/kg in kidney to >20,000 mg/kg in brain in both groups.	Cyclodextrins	100-112	NPC intracellular cholesterol transporter 2	Mus musculus	40-44
21116615-3	2011	Cyclodextrins were found to enhance the PIF signal.	Cyclodextrins	0-13	PIF1 5'-to-3' DNA helicase	Homo sapiens	40-43
21438042-3	2011	The inclusion complexes of a series of cyclodextrins (CDs) and alkanes/fluoroalkyl-grafted alkanes were synthesized and measured by surface tension, XRD, XPS, TGA, and NMR spectroscopy.	Cyclodextrins	39-52	T-box transcription factor 1	Homo sapiens	159-162
21289032-4	2011	The transport defect in mutants lacking NPC2 or NPC1, but not in those lacking LAL, was reversed by cyclodextrin (CD), and the ED50 values for this reversal varied from ~40 mg/kg in kidney to >20,000 mg/kg in brain in both groups.	Cyclodextrins	100-112	NPC intracellular cholesterol transporter 1	Mus musculus	48-52
21289032-4	2011	The transport defect in mutants lacking NPC2 or NPC1, but not in those lacking LAL, was reversed by cyclodextrin (CD), and the ED50 values for this reversal varied from ~40 mg/kg in kidney to >20,000 mg/kg in brain in both groups.	Cyclodextrins	114-116	NPC intracellular cholesterol transporter 2	Mus musculus	40-44
21289032-4	2011	The transport defect in mutants lacking NPC2 or NPC1, but not in those lacking LAL, was reversed by cyclodextrin (CD), and the ED50 values for this reversal varied from ~40 mg/kg in kidney to >20,000 mg/kg in brain in both groups.	Cyclodextrins	114-116	NPC intracellular cholesterol transporter 1	Mus musculus	48-52
21289032-8	2011	In both npc2(-/-) and npc1(-/-) mice, the transport defect was reversed by a CD that interacted with UC, likely at the membrane/bulk-water interface, allowing sterol to move rapidly to the export site of the E/L compartment.	Cyclodextrins	77-79	NPC intracellular cholesterol transporter 2	Mus musculus	8-12
21289032-8	2011	In both npc2(-/-) and npc1(-/-) mice, the transport defect was reversed by a CD that interacted with UC, likely at the membrane/bulk-water interface, allowing sterol to move rapidly to the export site of the E/L compartment.	Cyclodextrins	77-79	NPC intracellular cholesterol transporter 1	Mus musculus	22-26
21720512-3	2011	Herein, the physicochemical characterization and in vivo ACE inhibition evaluation of seven CAP/CD complexes are reported.	Cyclodextrins	96-98	angiotensin I converting enzyme	Rattus norvegicus	57-60
21433206-1	2011	The interactions of cyclodextrins (CDs) with human serum albumin (HSA) and bovine serum albumin (BSA) were investigated by two-dimensional nuclear Overhauser effect spectroscopy (2D NOESY), steady state fluorescence, isothermal titration calorimetry, and circular dichroism spectroscopy.	Cyclodextrins	20-33	albumin	Homo sapiens	51-64
21433206-1	2011	The interactions of cyclodextrins (CDs) with human serum albumin (HSA) and bovine serum albumin (BSA) were investigated by two-dimensional nuclear Overhauser effect spectroscopy (2D NOESY), steady state fluorescence, isothermal titration calorimetry, and circular dichroism spectroscopy.	Cyclodextrins	20-33	albumin	Homo sapiens	82-95
21433206-1	2011	The interactions of cyclodextrins (CDs) with human serum albumin (HSA) and bovine serum albumin (BSA) were investigated by two-dimensional nuclear Overhauser effect spectroscopy (2D NOESY), steady state fluorescence, isothermal titration calorimetry, and circular dichroism spectroscopy.	Cyclodextrins	35-38	albumin	Homo sapiens	51-64
21433206-1	2011	The interactions of cyclodextrins (CDs) with human serum albumin (HSA) and bovine serum albumin (BSA) were investigated by two-dimensional nuclear Overhauser effect spectroscopy (2D NOESY), steady state fluorescence, isothermal titration calorimetry, and circular dichroism spectroscopy.	Cyclodextrins	35-38	albumin	Homo sapiens	82-95
22081768-2	2011	As a nanometer-scale drug carrier system, the cyclodextrin polymeric nanoparticle technology, referred to as "CDP", has unique design features and capabilities.	Cyclodextrins	46-58	cut like homeobox 1	Homo sapiens	110-113
20581737-0	2010	Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.	Cyclodextrins	7-19	NPC intracellular cholesterol transporter 1	Mus musculus	98-118
20863684-2	2010	Dopamine (DA) quantification is presented using a screen-printed electrode modified by electropolymerization of cyclodextrin with glucose oxidase, SPE/MWCNT/beta-CD-GOx.	Cyclodextrins	112-124	hydroxyacid oxidase 1	Homo sapiens	130-145
20810659-7	2010	Intriguingly, disruption of cellular cholesterol by cyclodextrin perturbed TRIM5alpha cytoplasmic body formation.	Cyclodextrins	52-64	tripartite motif containing 5	Homo sapiens	75-85
20701921-1	2010	Cyclodextrin (CD) modulated interactions between ionic surfactants with opposite charge and bovine serum albumin (BSA) at specific and nonspecific binding stages have been studied by isothermal titration calorimetry (ITC), fluorescence spectra and circular dichroism spectral measurements.	Cyclodextrins	0-12	albumin	Homo sapiens	99-112
20701921-1	2010	Cyclodextrin (CD) modulated interactions between ionic surfactants with opposite charge and bovine serum albumin (BSA) at specific and nonspecific binding stages have been studied by isothermal titration calorimetry (ITC), fluorescence spectra and circular dichroism spectral measurements.	Cyclodextrins	14-16	albumin	Homo sapiens	99-112
22084730-4	2011	This combination of cyclodextrin + interleukin-2 led to the decrease of interleukin-2 effective concentration by an order.	Cyclodextrins	20-32	interleukin 2	Homo sapiens	72-85
21030027-0	2010	Sub-1-micron mesoporous silica particles functionalized with cyclodextrin derivative for rapid enantioseparations on ultra-high pressure liquid chromatography.	Cyclodextrins	61-73	SUB1 regulator of transcription	Homo sapiens	0-5
21054067-7	2010	The results are relevant for the reversible adsorption of silica particles onto hydrophilic polymers, used in the process of formation of mesoporous materials of the type SBA or MCM, cross-linked cyclodextrin molecules threading on the polymers and forming the structures known as polyrotaxanes.	Cyclodextrins	196-208	methylmalonyl-CoA mutase	Homo sapiens	178-181
20727924-0	2010	Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin.	Cyclodextrins	0-12	insulin	Homo sapiens	23-30
20727924-0	2010	Cyclodextrin complexed insulin encapsulated hydrogel microparticles: An oral delivery system for insulin.	Cyclodextrins	0-12	insulin	Homo sapiens	97-104
20727924-12	2010	Cyclodextrin complexed insulin encapsulated hydrogel microparticles appear to be an interesting candidate for oral delivery of insulin.	Cyclodextrins	0-12	insulin	Homo sapiens	23-30
20727924-12	2010	Cyclodextrin complexed insulin encapsulated hydrogel microparticles appear to be an interesting candidate for oral delivery of insulin.	Cyclodextrins	0-12	insulin	Homo sapiens	127-134
20581737-7	2010	These studies demonstrated that weekly cyclodextrin administration overcomes the lysosomal transport defect associated with the NPC1 mutation, nearly normalizes hepatic and whole animal cholesterol pools, and prevents the development of liver disease.	Cyclodextrins	39-51	NPC intracellular cholesterol transporter 1	Mus musculus	128-132
20718443-6	2010	The comparative efficiency of the PS/CD nanofibers/nanoweb for removing phenolphthalein, a model organic compound, from solution was determined by UV-vis spectrometry, and the kinetics of phenolphthalein capture was shown to follow the trend PS/alpha-CD > PS/beta-CD > PS/gamma-CD.	Cyclodextrins	37-39	pregnancy specific beta-1-glycoprotein 1	Homo sapiens	259-269
20668321-3	2010	MATERIALS AND METHODS: The studies include determination of emitted electrons (e(-)(aq)) by the individual hormones as well as by their mixtures, all complexed with cyclodextrin (HBC).	Cyclodextrins	165-177	keratin 88, pseudogene	Homo sapiens	179-182
20655192-8	2010	The bioactivity of immobilized glucose oxidase was maintained due to the biocompatibility of cyclodextrin.	Cyclodextrins	93-105	hydroxyacid oxidase 1	Homo sapiens	31-46
20550194-0	2010	Inclusion complex of a Bcl-2 inhibitor with cyclodextrin: characterization, cellular accumulation, and in vivo antitumor activity.	Cyclodextrins	44-56	BCL2 apoptosis regulator	Homo sapiens	23-28
20222716-7	2010	alpha-Amylase binds three cyclodextrin molecules.	Cyclodextrins	26-38	LOW QUALITY PROTEIN: pancreatic alpha-amylase	Sus scrofa	0-13
20433173-5	2010	It is revealed that the reaction is initialized first by binding substrates into the cyclodextrin cavity via a synergistic action of hydrophobic interaction and noncovalent interaction with the CD-1 side chain.	Cyclodextrins	85-97	CD1c molecule	Homo sapiens	194-198
19965601-0	2010	Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid.	Cyclodextrins	0-12	NPC intracellular cholesterol transporter 1	Mus musculus	69-73
20175983-8	2010	The refolding of two selected targets, the mouse cannabinoid receptor 1 (muCB1R) and the human parathyroid hormone receptor 1 (huPTH1R), was achieved from solubilized receptors using detergent and cyclodextrin as protein folding assistants.	Cyclodextrins	197-209	cannabinoid receptor 1 (brain)	Mus musculus	49-71
20175983-8	2010	The refolding of two selected targets, the mouse cannabinoid receptor 1 (muCB1R) and the human parathyroid hormone receptor 1 (huPTH1R), was achieved from solubilized receptors using detergent and cyclodextrin as protein folding assistants.	Cyclodextrins	197-209	parathyroid hormone 1 receptor	Homo sapiens	95-125
20387827-7	2010	It is the cyclodextrin/pyrene inclusion interaction that allows modulating the degree of conformational constraints of P1 and P2 and thus their background signals and selectivity.	Cyclodextrins	10-22	crystallin gamma F, pseudogene	Homo sapiens	119-128
20211660-8	2010	Disruption of cholesterol-rich membrane domains by cyclodextrin reduced MR-EGFR interaction.	Cyclodextrins	51-63	nuclear receptor subfamily 3 group C member 2	Homo sapiens	72-74
20211660-8	2010	Disruption of cholesterol-rich membrane domains by cyclodextrin reduced MR-EGFR interaction.	Cyclodextrins	51-63	epidermal growth factor receptor	Homo sapiens	75-79
19836468-1	2010	UNLABELLED: The goal of this study was to evaluate the mechanism of cyclodextrin-based nanoparticle (CDP-NP) uptake into a murine glioma model.	Cyclodextrins	68-80	cut-like homeobox 1	Mus musculus	101-104
19836468-6	2010	FROM THE CLINICAL EDITOR: The goal of this study was to evaluate the mechanism of cyclodextrin-based nanoparticle (CDP-NP) uptake into a murine glioma model.	Cyclodextrins	82-94	cut-like homeobox 1	Mus musculus	115-118
20212119-6	2010	To test this further, we incubated both NPC1 and NPC2 mutant cells with cholesterol-loaded cyclodextrin for 1 h, followed by chase in serum-containing medium.	Cyclodextrins	91-103	NPC intracellular cholesterol transporter 2	Mus musculus	49-53
20212119-12	2010	These findings suggest that cyclodextrin-mediated enhanced cholesterol transport from the endocytic system can reduce cholesterol accumulation in cells with defects in either NPC1 or NPC2.	Cyclodextrins	28-40	NPC intracellular cholesterol transporter 1	Mus musculus	175-179
20212119-12	2010	These findings suggest that cyclodextrin-mediated enhanced cholesterol transport from the endocytic system can reduce cholesterol accumulation in cells with defects in either NPC1 or NPC2.	Cyclodextrins	28-40	NPC intracellular cholesterol transporter 2	Mus musculus	183-187
20176935-4	2010	Inhibition of mTOR by itraconazole but not rapamycin can be partially restored by extracellular cholesterol delivered by cyclodextrin.	Cyclodextrins	121-133	mechanistic target of rapamycin kinase	Homo sapiens	14-18
20141116-1	2010	Principal component analysis (PCA) was applied for postprocessing of trajectories from conformational search, based on 50.0 ns molecular dynamics (MD) simulations, with the purpose to elucidate the conformations of some large-ring cyclodextrins (LR-CDs), CDn (n = 24, 25, 26, 27, 28, 29).	Cyclodextrins	231-244	5', 3'-nucleotidase, cytosolic	Homo sapiens	255-258
20631433-1	2010	Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry of a model peptide, Substance P (SubP), was carried out using 2,4,6-trihydroxyacetophenone (THAP) and 2,4-dihydroxyacetophenone (DHAP) with cyclodextrins (cyclodextrin-supported matrix).	Cyclodextrins	210-223	tachykinin precursor 1	Homo sapiens	103-107
20631433-1	2010	Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry of a model peptide, Substance P (SubP), was carried out using 2,4,6-trihydroxyacetophenone (THAP) and 2,4-dihydroxyacetophenone (DHAP) with cyclodextrins (cyclodextrin-supported matrix).	Cyclodextrins	210-222	tachykinin precursor 1	Homo sapiens	90-101
20631433-1	2010	Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry of a model peptide, Substance P (SubP), was carried out using 2,4,6-trihydroxyacetophenone (THAP) and 2,4-dihydroxyacetophenone (DHAP) with cyclodextrins (cyclodextrin-supported matrix).	Cyclodextrins	210-223	tachykinin precursor 1	Homo sapiens	90-101
20631433-1	2010	Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry of a model peptide, Substance P (SubP), was carried out using 2,4,6-trihydroxyacetophenone (THAP) and 2,4-dihydroxyacetophenone (DHAP) with cyclodextrins (cyclodextrin-supported matrix).	Cyclodextrins	210-222	tachykinin precursor 1	Homo sapiens	103-107
19155269-2	2009	In liver cells, the structures of alpha-glucans proximal to the site GDE acts are not cyclodextrins, but glycogen and its degradation products.	Cyclodextrins	86-99	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	69-72
19884502-0	2009	Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells.	Cyclodextrins	0-12	protein interacting with PRKCA 1	Homo sapiens	103-107
19446755-0	2009	Slow-release system of pegylated lysozyme utilizing formation of polypseudorotaxanes with cyclodextrins.	Cyclodextrins	90-103	lysozyme	Homo sapiens	33-41
19420793-0	2009	Polypseudorotaxane formation of randomly-pegylated insulin with cyclodextrins: slow release and resistance to enzymatic degradation.	Cyclodextrins	64-77	insulin	Homo sapiens	51-58
19420793-2	2009	In this study, we prepared a insulin derivative substituted randomly with poly(ethylene glycol) (PEG, MW about 2200) and its polypseudorotaxanes with cyclodextrins (CyDs).	Cyclodextrins	150-163	insulin	Homo sapiens	29-36
19420793-2	2009	In this study, we prepared a insulin derivative substituted randomly with poly(ethylene glycol) (PEG, MW about 2200) and its polypseudorotaxanes with cyclodextrins (CyDs).	Cyclodextrins	165-169	insulin	Homo sapiens	29-36
19281845-3	2009	The quasi-emulsion solvent diffusion technique was used to prepare the NPs with natural and chemically modified (HP-beta-CD and Me-beta-CD) CDs.	Cyclodextrins	140-143	beta-carotene oxygenase 1	Mus musculus	116-123
19281845-3	2009	The quasi-emulsion solvent diffusion technique was used to prepare the NPs with natural and chemically modified (HP-beta-CD and Me-beta-CD) CDs.	Cyclodextrins	140-143	beta-carotene oxygenase 1	Mus musculus	131-138
19382700-1	2009	This was the first study to apply cyclodextrin glucanotransferases (CGTase, EC 2.4.1.19) produced by mesophilic, thermophilic, alkaliphilic, and halophilic bacilli as well as pullulanase, beta-amylase, beta-galactosidase, and beta-fructofuranosidase for transglycosylation of benzo[h]quinazolines.	Cyclodextrins	34-46	galactosidase beta 1	Homo sapiens	202-220
19275898-2	2009	The GWD3 CBM20 has 50-fold lower affinity for cyclodextrins than that from GA. Homology modelling identified possible structural elements responsible for this weak binding of the intracellular CBM20.	Cyclodextrins	46-59	phosphoglucan, water dikinase	Arabidopsis thaliana	4-8
18956389-0	2008	Simultaneous enantioseparation of four beta2-agonists by capillary electrophoresis with cyclodextrin additives.	Cyclodextrins	88-100	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	39-44
19255549-5	2009	The binding of 3 by the three cyclodextrin hosts generally decreased in the order of 1>2>b-CD.	Cyclodextrins	30-42	cytochrome P450 family 4 subfamily V member 2	Homo sapiens	95-99
19113826-5	2009	The ability of the duplex cyclodextrin 6 to bind alpha,omega-alkanediols (C9-C14) and 1-alkanols (C9 and C10) was studied by isothermal titration calorimetry in aqueous solutions.	Cyclodextrins	26-38	homeobox C10	Homo sapiens	105-108
19067026-9	2009	Instead, IL-12Rbeta2 is found more segregated into membrane rafts, which could explain why two IL-12-triggered events, T-cell proliferation and ERK1/2 activation, are both methyl-beta-cyclodextrin-sensitive events.	Cyclodextrins	184-196	mitogen-activated protein kinase 3	Homo sapiens	144-150
18711208-4	2008	Depleting the apical or the basolateral membrane of cholesterol by cyclodextrin attenuates the amount of cholesterol transported by ABCA1 without altering ABCA1 expression.	Cyclodextrins	67-79	ATP binding cassette subfamily A member 1	Homo sapiens	132-137
18387943-7	2008	Cyclodextrin treatment disrupts caveolae and blocks PMA-dependent PKCdelta-Tyr(311) phosphorylation, without blocking H(2)O(2)-dependent PKCdelta-Tyr(311) phosphorylation.	Cyclodextrins	0-12	protein kinase C, delta	Mus musculus	66-74
18617650-5	2008	Cyclodextrin, but not cyclodextrin/cholesterol complex, also inhibited PMA-induced CD11b activation implicating cholesterol efflux as the main mechanism.	Cyclodextrins	0-12	integrin subunit alpha M	Homo sapiens	83-88
18798665-0	2008	Native and methylated cyclodextrins with positive and negative solubility coefficients in water studied by SAXS and SANS.	Cyclodextrins	22-35	USH1 protein network component sans	Homo sapiens	116-120
18539442-8	2008	Our data suggest that Pgp inhibition by cyclodextrin treatments arises through modulation of its membrane microenvironment, rather than as a result of concomitant cytotoxicity.	Cyclodextrins	40-52	ATP binding cassette subfamily B member 1	Homo sapiens	22-25
17706427-1	2008	Cyclodextrin-based aggregates have been widely investigated with microscopies such as STM, AFM, SEM, TEM, and fluorescent microscopy to obtain the direct morphology and structure of samples.	Cyclodextrins	0-12	sulfotransferase family 1A member 3	Homo sapiens	86-89
18270319-0	2008	Delivery of galanin-like peptide to the brain: targeting with intranasal delivery and cyclodextrins.	Cyclodextrins	86-99	galanin-like peptide	Mus musculus	12-32
17438337-5	2007	After cholesterol-cyclodextrin (Chol-CD) treatment, CE secretion was increased by 27-fold in ACAT2-transfected cells but by only 7-fold in control cells.	Cyclodextrins	18-30	acetyl-CoA acetyltransferase 2	Homo sapiens	93-98
18443290-9	2008	We used this mutant for the detection of adenosine diphosphate at the single-molecule level, after equipping the porin with a cyclodextrin molecular adapter, thereby demonstrating its potential for use in stochastic sensing applications.	Cyclodextrins	126-138	voltage dependent anion channel 1	Homo sapiens	113-118
17588144-4	2008	Replacement of Mg2+ ion with other type of ions which interact with alpha-cyclodextrin interfere with the function of cyclodextrin resulting in low refolding yields.	Cyclodextrins	74-86	mucin 7, secreted	Homo sapiens	15-18
17932048-7	2007	The slow decline in ENaC activity in response to apical cyclodextrin was identical to the rate of decline seen when protein synthesis was inhibited by cycloheximide.	Cyclodextrins	56-68	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	20-24
17932048-8	2007	Apical biotinylation of (MPK)CCD(14) cells confirmed the loss of ENaC at the cell surface following cyclodextrin treatment.	Cyclodextrins	100-112	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	65-69
17932048-10	2007	Expression of dominant negative caveolin isoforms (CAV1-eGFP and CAV3-DGV) which disrupt caveolae, reduced basal ENaC currents by 72.3 and 78.2%, respectively; but, as with cyclodextrin, the acute response to forskolin was unaffected.	Cyclodextrins	173-185	caveolin 1, caveolae protein	Mus musculus	32-40
17932048-10	2007	Expression of dominant negative caveolin isoforms (CAV1-eGFP and CAV3-DGV) which disrupt caveolae, reduced basal ENaC currents by 72.3 and 78.2%, respectively; but, as with cyclodextrin, the acute response to forskolin was unaffected.	Cyclodextrins	173-185	caveolin 1, caveolae protein	Mus musculus	51-55
17579761-1	2007	Highly sensitive and selective detection of 2,4-DNT, a representative explosive, was achieved by the synergic effect of molecular imprinting and host (cyclodextrin)-guest interaction in ultrathin layers of TiO(2) and SiO(2) gel; the detection limit using cSPI measurements reached nM concentration.	Cyclodextrins	151-163	5', 3'-nucleotidase, cytosolic	Homo sapiens	48-51
17616681-9	2007	Phosphorylation of Akt substrates in lipid raft fractions, but not in cytosol/nonraft membrane fractions, was ablated with cyclodextrin.	Cyclodextrins	123-135	AKT serine/threonine kinase 1	Homo sapiens	19-22
18077828-5	2008	Daily treatment of the npc1(-/-) mice with an LXR agonist or administration of a single dose of cyclodextrin, with or without the neurosteroid allopregnanolone, significantly slowed neurodegeneration and increased the lifespan of these animals.	Cyclodextrins	96-108	NPC intracellular cholesterol transporter 1	Mus musculus	23-27
18077828-6	2008	These data illustrate that the age at death of the npc1(-/-) mouse can be significantly influenced by many factors, including differences in strain background, other inactivating gene mutations (Siat9 and lxrbeta), and administration of agents such as LXR agonists and, particularly, cyclodextrin.	Cyclodextrins	284-296	NPC intracellular cholesterol transporter 1	Mus musculus	51-55
17892503-17	2008	The effect of cyclodextrin indicated that cholesterol extraction interfered with PKG inhibition of NOS.	Cyclodextrins	14-26	protein kinase cGMP-dependent 1	Homo sapiens	81-84
17625898-3	2007	Supported monolayers of amphiphilic cyclodextrins CD1 and CD2 were obtained by adsorption of CD vesicles to hydrophobic substrates, and supported bilayers of amphiphilic cyclodextrins CD1 and CD2 were prepared by adsorption of CD vesicles on cationic substrates.	Cyclodextrins	36-49	CD1c molecule	Homo sapiens	50-53
17446044-9	2007	Chemical disruption of caveolae with cyclodextrin or filipin prevented Akt activation, and both EGFR and Akt activation were lost in caveolin-1 (cav-1) knockout MC.	Cyclodextrins	37-49	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
17718201-8	2007	To see the effect of the ionic groups an anionic and a cationic CD derivative were also investigated: (2-hydroxy-3-N,N,N-trimethylamino)propyl beta-CD (QABCD) (DS = 2) and carboxymethylated beta-CD (CMBCD) (DS = 3,5).	Cyclodextrins	64-66	beta-carotene oxygenase 1	Mus musculus	143-150
17554422-0	2007	Prediction of PAH biodegradation in field contaminated soils using a cyclodextrin extraction technique.	Cyclodextrins	69-81	phenylalanine hydroxylase	Homo sapiens	14-17
17506539-1	2007	We report on steady-state and ps-time-resolved emission studies of piroxicam (1) drug within human serum albumin (HSA) protein in cyclodextrin and in neat solvents.	Cyclodextrins	130-142	albumin	Homo sapiens	99-118
17121865-3	2007	Cyclodextrin and filipin, agents that disrupt caveolae, abrogated strain-induced RhoA activation in mesangial cells.	Cyclodextrins	0-12	ras homolog family member A	Homo sapiens	81-85
16859961-3	2007	The o-HTPP forms 1:2 inclusion complexes with TM-beta-CD and 1:1 inclusion complexes with the other five cyclodextrins.	Cyclodextrins	105-118	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	49-62
17079792-8	2007	Modification of lipid rafts by cyclodextrin and nystatin corrected the abnormal response, suggesting an association between the increased lipid rafts and abnormal TNF-alpha secretion.	Cyclodextrins	31-43	tumor necrosis factor	Mus musculus	163-172
17194112-2	2007	Subsequently, pseudorotaxanes 2 were further assembled to form a 2D pseudopolyrotaxane (3) through an alpha,omega-PPG2000 diamino polymer threading the cavities of cyclodextrins in 2, and the resulting pseudopolyrotaxane was comprehensively characterized by FT-IR, NMR, TG-DTA, elemental analysis, and transmission electron microscopy.	Cyclodextrins	164-177	serglycin	Homo sapiens	114-117
17255536-9	2007	Preincubation with cyclodextrin-cholesterol caused accumulation of cellular cholesterol, increased thrombin-induced FGF-2 release, and stimulated FGF-2 de novo synthesis.	Cyclodextrins	19-31	coagulation factor II, thrombin	Homo sapiens	99-107
17255536-9	2007	Preincubation with cyclodextrin-cholesterol caused accumulation of cellular cholesterol, increased thrombin-induced FGF-2 release, and stimulated FGF-2 de novo synthesis.	Cyclodextrins	19-31	fibroblast growth factor 2	Homo sapiens	116-121
17255536-9	2007	Preincubation with cyclodextrin-cholesterol caused accumulation of cellular cholesterol, increased thrombin-induced FGF-2 release, and stimulated FGF-2 de novo synthesis.	Cyclodextrins	19-31	fibroblast growth factor 2	Homo sapiens	146-151
17121865-7	2007	Cyclodextrin and filipin inhibited the strain-induced RhoA/cav-1 association, indicating dependence on caveolar structural integrity.	Cyclodextrins	0-12	ras homolog family member A	Homo sapiens	54-58
17121865-7	2007	Cyclodextrin and filipin inhibited the strain-induced RhoA/cav-1 association, indicating dependence on caveolar structural integrity.	Cyclodextrins	0-12	caveolin 1	Homo sapiens	59-64
17121865-8	2007	Restoration of caveolae by coincubation of cyclodextrin with cholesterol rescued both RhoA activation and RhoA/cav-1 association in response to strain.	Cyclodextrins	43-55	ras homolog family member A	Homo sapiens	86-90
17121865-8	2007	Restoration of caveolae by coincubation of cyclodextrin with cholesterol rescued both RhoA activation and RhoA/cav-1 association in response to strain.	Cyclodextrins	43-55	ras homolog family member A	Homo sapiens	106-110
17121865-8	2007	Restoration of caveolae by coincubation of cyclodextrin with cholesterol rescued both RhoA activation and RhoA/cav-1 association in response to strain.	Cyclodextrins	43-55	caveolin 1	Homo sapiens	111-116
16359784-6	2006	Findings from this study also demonstrated that cyclodextrin assisted electrokinetics can enhance the removal rate of naphthalene and 2,4-DNT.	Cyclodextrins	48-60	5', 3'-nucleotidase, cytosolic	Homo sapiens	138-141
17706183-8	2007	Of the four CDs tested for their ability to complex with Hex-PAH, only BCDX12 formed stable complexes with Hex-PAH under the test conditions.	Cyclodextrins	12-15	hematopoietically expressed homeobox	Homo sapiens	57-60
16917853-0	2006	Effects of cyclodextrins on chemically and thermally induced unfolding and aggregation of lysozyme and basic fibroblast growth factor.	Cyclodextrins	11-24	lysozyme	Homo sapiens	90-98
16917853-0	2006	Effects of cyclodextrins on chemically and thermally induced unfolding and aggregation of lysozyme and basic fibroblast growth factor.	Cyclodextrins	11-24	fibroblast growth factor 2	Homo sapiens	103-133
16917853-1	2006	Effects of cyclodextrin (CyDs) on unfolding and aggregation of lysozyme and basic fibroblast growth factor (bFGF) were investigated.	Cyclodextrins	11-23	lysozyme	Homo sapiens	63-71
17002685-0	2006	Cyclodextrin-induced apoptosis in human keratinocytes is caspase-8 dependent and accompanied by mitochondrial cytochrome c release.	Cyclodextrins	0-12	caspase 8	Homo sapiens	57-66
17002685-0	2006	Cyclodextrin-induced apoptosis in human keratinocytes is caspase-8 dependent and accompanied by mitochondrial cytochrome c release.	Cyclodextrins	0-12	cytochrome c, somatic	Homo sapiens	110-122
17034250-0	2006	Dielectric studies of water clusters in cyclodextrins: Relevance to the transition between slow and fast forms of thrombin.	Cyclodextrins	40-53	coagulation factor II, thrombin	Homo sapiens	114-122
16883563-4	2006	The objective was to investigate the use of beta-lap inclusion complexes with cyclodextrins (CDs) to control beta-lap release kinetics from PLGA millirods.	Cyclodextrins	78-91	LAP	Homo sapiens	49-52
16883563-4	2006	The objective was to investigate the use of beta-lap inclusion complexes with cyclodextrins (CDs) to control beta-lap release kinetics from PLGA millirods.	Cyclodextrins	78-91	LAP	Homo sapiens	114-117
16883563-4	2006	The objective was to investigate the use of beta-lap inclusion complexes with cyclodextrins (CDs) to control beta-lap release kinetics from PLGA millirods.	Cyclodextrins	93-96	LAP	Homo sapiens	49-52
16883563-4	2006	The objective was to investigate the use of beta-lap inclusion complexes with cyclodextrins (CDs) to control beta-lap release kinetics from PLGA millirods.	Cyclodextrins	93-96	LAP	Homo sapiens	114-117
16883563-11	2006	These data demonstrate the ability to tailor beta-lap release kinetics via CD complexation, providing exciting opportunities for the use of beta-lap-millirods for intratumoral drug delivery.	Cyclodextrins	75-77	LAP	Homo sapiens	50-53
16883563-11	2006	These data demonstrate the ability to tailor beta-lap release kinetics via CD complexation, providing exciting opportunities for the use of beta-lap-millirods for intratumoral drug delivery.	Cyclodextrins	75-77	LAP	Homo sapiens	145-148
17048507-6	2006	The use of the liposome and cyclodextrin inclusion complexes resulted in a mean drug recovery of 77 and more then 90% respectively, after a light exposure until to 30 minutes with an intensity of 21 kJ x min(-1) m(-2).	Cyclodextrins	28-40	CD59 molecule (CD59 blood group)	Homo sapiens	204-210
16798776-0	2006	Activation of 4-alpha-glucanotransferase activity of porcine liver glycogen debranching enzyme with cyclodextrins.	Cyclodextrins	100-113	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	67-94
16806857-0	2006	Cyclodextrins in the production of large porous particles: development of dry powders for the sustained release of insulin to the lungs.	Cyclodextrins	0-13	insulin	Homo sapiens	115-122
16798776-3	2006	We examined the effects of cyclodextrins (CDs) on debranching activity of porcine liver GDE using a fluorogenic branched dextrin, Glcalpha1-4Glcalpha1-4Glcalpha1-4(Glcalpha1-4Glcalpha1-4Glcalpha1-4Glcalpha1-6)Glcalpha1-4Glcalpha1-4Glcalpha1-4Glcalpha1-4GlcPA (B5/84), as a substrate.	Cyclodextrins	27-40	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	88-91
16798776-3	2006	We examined the effects of cyclodextrins (CDs) on debranching activity of porcine liver GDE using a fluorogenic branched dextrin, Glcalpha1-4Glcalpha1-4Glcalpha1-4(Glcalpha1-4Glcalpha1-4Glcalpha1-4Glcalpha1-6)Glcalpha1-4Glcalpha1-4Glcalpha1-4Glcalpha1-4GlcPA (B5/84), as a substrate.	Cyclodextrins	42-45	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	88-91
16798776-6	2006	alpha-, beta- and gamma-CDs accelerated the liberation of B5/81 from B5/84, indicating that the 4-alpha-glucanotransferase activity was activated by CDs to remove the maltotriosyl residue from the maltotetraosyl branch.	Cyclodextrins	24-27	glycoprotein hormone subunit beta 5	Homo sapiens	58-63
16798776-6	2006	alpha-, beta- and gamma-CDs accelerated the liberation of B5/81 from B5/84, indicating that the 4-alpha-glucanotransferase activity was activated by CDs to remove the maltotriosyl residue from the maltotetraosyl branch.	Cyclodextrins	24-27	glycoprotein hormone subunit beta 5	Homo sapiens	69-74
16571669-4	2006	RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin.	Cyclodextrins	310-322	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	90-94
16556852-6	2006	LXR activation increased macrophage cholesterol efflux to high-density lipoprotein (HDL), low-density lipoprotein (LDL), and cyclodextrin in an ABCG1-dependent fashion.	Cyclodextrins	125-137	ATP binding cassette subfamily G member 1	Homo sapiens	144-149
16571669-4	2006	RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin.	Cyclodextrins	310-322	ceramide transfer protein	Cricetulus griseus	193-197
16629272-1	2006	Several methods (cosolvents, surfactants, and cyclodextrins) were compared for improving desorption of a high explosive, RDX, from granular activated carbon (GAC).	Cyclodextrins	46-59	radixin	Homo sapiens	121-124
16734766-9	2006	However, treatment of the cells with progesterone, an inhibitor of NPC1-dependent endosomal cholesterol trafficking, not only markedly reduced the hypotonicity-provoked anion efflux, but also prevented its potentiation by cyclodextrin.	Cyclodextrins	222-234	NPC intracellular cholesterol transporter 1	Homo sapiens	67-71
16464592-3	2006	This increase was attributed to the cholesterol extraction property of these cyclodextrins from brain capillary endothelial cells leading to a modulation of the P-gp activity.	Cyclodextrins	77-90	phosphoglycolate phosphatase	Homo sapiens	161-165
16711695-0	2006	Iron porphyrin-cyclodextrin supramolecular complex as a functional model of myoglobin in aqueous solution.	Cyclodextrins	15-27	myoglobin	Homo sapiens	76-85
18970501-2	2006	Multivariate regression models (PLS-1) were developed from spectral data obtained on solutions containing N,N"-bis-(alpha-methylbenzyl)sulfamide or tryptophan methyl ester hydrochloride in the presence of sodium dodecyl sulfate and mixed cyclodextrin host molecules.	Cyclodextrins	238-250	plastin 1	Homo sapiens	32-37
16294257-0	2005	Skeleton-selective fluorescent chemosensor based on cyclodextrin bearing a 4-amino-7-nitrobenz-2-oxa-1,3-diazole moiety.	Cyclodextrins	52-64	OXA1L mitochondrial inner membrane protein	Homo sapiens	97-102
16219508-0	2005	Enhancement of PAH biomineralization rates by cyclodextrins under Fe(III)-reducing conditions.	Cyclodextrins	46-59	phenylalanine hydroxylase	Homo sapiens	15-18
16106289-0	2005	Spin-labelled cyclodextrins as hosts for large supramolecular assemblies.	Cyclodextrins	14-27	spindlin 1	Homo sapiens	0-4
32646105-1	2005	This work focuses on the synthesis of polyrotaxanes with high molecular weight template poly(ethylene glycol) PEG (20 kg mol) having various and well-defined amounts of alpha-cyclodextrins (alpha-CD) per chain from 3 up to 125. is the complexation degree of the polyrotaxane defined to be the average number of cyclodextrin molecules per template chain.	Cyclodextrins	175-187	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	190-198
16204072-3	2005	The nonviral delivery system uses a cyclodextrin-containing polycation to bind and protect siRNA and transferrin as a targeting ligand for delivery to transferrin receptor-expressing tumor cells.	Cyclodextrins	36-48	transferrin	Mus musculus	101-112
16204072-3	2005	The nonviral delivery system uses a cyclodextrin-containing polycation to bind and protect siRNA and transferrin as a targeting ligand for delivery to transferrin receptor-expressing tumor cells.	Cyclodextrins	36-48	transferrin	Mus musculus	151-162
16106289-1	2005	EPR spectroscopy was used to study formation of inclusion complexes of monofunctionalised spin-labelled beta-cyclodextrins; this method is very sensitive to the interactions of cyclodextrins with large guest molecules.	Cyclodextrins	109-122	spindlin 1	Homo sapiens	90-94
16123345-3	2005	Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1beta-induced gene expression of inducible NO synthase (iNOS) and NO release from beta-cells.	Cyclodextrins	38-50	interleukin 1 beta	Homo sapiens	69-77
16123345-3	2005	Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1beta-induced gene expression of inducible NO synthase (iNOS) and NO release from beta-cells.	Cyclodextrins	38-50	nitric oxide synthase 2	Homo sapiens	105-126
16123345-3	2005	Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1beta-induced gene expression of inducible NO synthase (iNOS) and NO release from beta-cells.	Cyclodextrins	38-50	nitric oxide synthase 2	Homo sapiens	128-132
15827645-0	2005	Cyclodextrin and modified cyclodextrin complexes of E-4-tert-butylphenyl-4"-oxyazobenzene: UV-visible, 1H NMR and ab initio studies.	Cyclodextrins	0-12	ubiquitination factor E4A	Homo sapiens	52-55
16401581-5	2005	All CDs improved thermal stability of insulin by lowering the enthalpy of unfolding by 16-52%.	Cyclodextrins	4-7	insulin	Bos taurus	38-45
16401581-8	2005	All CDs decreased the initial burst release of insulin by up to 30%.	Cyclodextrins	4-7	insulin	Bos taurus	47-54
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	314-326	adrenoceptor alpha 1D	Homo sapiens	59-67
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	314-326	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	80-87
16076143-5	2005	The results indicated that the cycloamylose formed by the cyclization reaction of the enzyme included Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein.	Cyclodextrins	31-43	immunoglobulin binding protein 1	Homo sapiens	106-114
16076143-5	2005	The results indicated that the cycloamylose formed by the cyclization reaction of the enzyme included Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein.	Cyclodextrins	31-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	120-127
16076143-5	2005	The results indicated that the cycloamylose formed by the cyclization reaction of the enzyme included Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein.	Cyclodextrins	31-43	immunoglobulin binding protein 1	Homo sapiens	143-151
16076143-5	2005	The results indicated that the cycloamylose formed by the cyclization reaction of the enzyme included Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein.	Cyclodextrins	31-43	immunoglobulin binding protein 1	Homo sapiens	143-151
16076143-5	2005	The results indicated that the cycloamylose formed by the cyclization reaction of the enzyme included Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein.	Cyclodextrins	31-43	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	171-178
15883155-9	2005	Glycodelin-S at physiological concentrations significantly reduced the bovine serum albumin and cyclodextrin-induced cholesterol efflux and down-regulated the adenylyl cyclase/protein kinase A/tyrosine kinase signaling pathway, resulting in suppression of capacitation.	Cyclodextrins	96-108	progestagen associated endometrial protein	Homo sapiens	0-12
16029163-3	2005	Purified His-hSR was refolded in Tween 20/cycloamylose with approximately 50% efficiency, and refolded His-hSR was isolated by Q Sepharose column chromatography.	Cyclodextrins	42-54	HSR	Homo sapiens	13-16
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	104-116	adrenoceptor alpha 1D	Homo sapiens	59-67
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	104-116	amyloid beta precursor protein	Homo sapiens	156-162
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	104-116	adrenoceptor alpha 1D	Homo sapiens	226-234
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	104-116	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	240-247
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	104-116	adrenoceptor alpha 1D	Homo sapiens	226-234
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	104-116	adrenoceptor alpha 1D	Homo sapiens	226-234
16076143-4	2005	The reaction products were isolated and identified as [Glc(alpha1-4)](1-22)-Glc(beta1-7)-genisteins and cycloamylose with DP 8-12 by HPLC and MALDI-TOF MS. A beta-amylase treatment revealed inclusion complexes composed of Glc(alpha1-4)-Glc(beta1-7)-genistein/Glc(alpha1-4)-Glc(alpha1-4)-Glc(beta1-7)-genistein and cycloamylose with DP 8-12.	Cyclodextrins	104-116	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	240-247
16004415-8	2005	The immobilized nanogels retained their ability to trap and release protein (insulin was used as a model protein) by host-guest interaction of the cholesteryl group and cyclodextrin and also showed high chaperone-like activity for refolding of chemically denatured protein.	Cyclodextrins	169-181	insulin	Homo sapiens	77-84
15855232-13	2005	The mobility of Kv1.3 was slightly increased following cyclodextrin treatment.	Cyclodextrins	55-67	potassium voltage-gated channel subfamily A member 3	Homo sapiens	16-21
15827645-0	2005	Cyclodextrin and modified cyclodextrin complexes of E-4-tert-butylphenyl-4"-oxyazobenzene: UV-visible, 1H NMR and ab initio studies.	Cyclodextrins	26-38	ubiquitination factor E4A	Homo sapiens	52-55
15852852-1	2005	Fluorescence and room temperature phosphoresce (CD-RTP) induced by cyclodextrin methods were employed to investigate the effects of steric hindrance of guest molecule on the formation of inclusion complexes of beta-cylcodextrin (beta-CD) and bromonaphthalene (BrN).	Cyclodextrins	67-79	MORN repeat containing 4	Homo sapiens	51-54
15748165-5	2005	Only CDs that lowered cholesterol levels redistributed the NMDA receptor NR2B subunit, PSD-95 (postsynaptic density protein 95 kDa) and neuronal nitric oxide synthase (nNOS) from Triton X-100 insoluble membrane domains to soluble fractions.	Cyclodextrins	5-8	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	73-77
15748165-5	2005	Only CDs that lowered cholesterol levels redistributed the NMDA receptor NR2B subunit, PSD-95 (postsynaptic density protein 95 kDa) and neuronal nitric oxide synthase (nNOS) from Triton X-100 insoluble membrane domains to soluble fractions.	Cyclodextrins	5-8	discs large MAGUK scaffold protein 4	Homo sapiens	87-93
15748165-5	2005	Only CDs that lowered cholesterol levels redistributed the NMDA receptor NR2B subunit, PSD-95 (postsynaptic density protein 95 kDa) and neuronal nitric oxide synthase (nNOS) from Triton X-100 insoluble membrane domains to soluble fractions.	Cyclodextrins	5-8	discs large MAGUK scaffold protein 4	Homo sapiens	95-130
15748165-5	2005	Only CDs that lowered cholesterol levels redistributed the NMDA receptor NR2B subunit, PSD-95 (postsynaptic density protein 95 kDa) and neuronal nitric oxide synthase (nNOS) from Triton X-100 insoluble membrane domains to soluble fractions.	Cyclodextrins	5-8	nitric oxide synthase 1	Homo sapiens	136-166
15748165-5	2005	Only CDs that lowered cholesterol levels redistributed the NMDA receptor NR2B subunit, PSD-95 (postsynaptic density protein 95 kDa) and neuronal nitric oxide synthase (nNOS) from Triton X-100 insoluble membrane domains to soluble fractions.	Cyclodextrins	5-8	nitric oxide synthase 1	Homo sapiens	168-172
15665979-2	2005	Partial-least-squares regression (PLS-1) models were developed from fluorescence spectral data obtained with a series of samples containing cyclodextrin guest-host complexes of phenylalanine with different known enantiomeric compositions.	Cyclodextrins	140-152	plastin 1	Homo sapiens	34-39
15665498-0	2005	Interaction of modified cyclodextrins with cytochrome P-450.	Cyclodextrins	24-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	43-59
15643890-1	2005	A series of cyclodextrin-based polypseudorotaxanes (PPRs) were constructed by threading native beta-cyclodextrin or l-tryptophan-modified beta-cyclodextrin onto the amino-terminated PPG chains of different lengths.	Cyclodextrins	12-24	serglycin	Homo sapiens	182-185
15665498-2	2005	The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations.	Cyclodextrins	13-16	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	45-52
15665498-2	2005	The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations.	Cyclodextrins	13-16	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	57-63
15619713-1	2005	We describe a detailed study on the possibility of analyzing aminated pesticides and metabolites using pre-column derivatization with fluorescein isothiocyanate (FITC) and their subsequent separation and detection by cyclodextrin capillary electrophoresis-laser-induced fluorescence (CE-LIF) detection.	Cyclodextrins	217-229	LIF interleukin 6 family cytokine	Homo sapiens	287-290
15653135-0	2005	How cyclodextrin incorporation affects the properties of protein-loaded PLGA-based microspheres: the case of insulin/hydroxypropyl-beta-cyclodextrin system.	Cyclodextrins	4-16	insulin	Homo sapiens	109-116
15653135-7	2005	In the case of microspheres prepared from emulsion, cyclodextrin reduced only insulin burst, whereas in the case of microspheres obtained from solution, the overall insulin release rate was slowed down.	Cyclodextrins	52-64	insulin	Homo sapiens	78-85
15665498-2	2005	The modified CDs inhibited the activities of CYP2C19 and CYP3A4 while enhancing CYP2C9 activity by 140 to 176% relative to the control values at lower concentrations.	Cyclodextrins	13-16	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	80-86
15665498-1	2005	The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4).	Cyclodextrins	24-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	131-147
15665498-1	2005	The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4).	Cyclodextrins	24-37	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	149-152
15665498-1	2005	The effects of modified cyclodextrins (CDs) hydroxypropyl-beta-CD and methyl-beta-CD were studied in vitro on cDNA-expressed human cytochrome P-450 (CYP) activities (CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4).	Cyclodextrins	39-42	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	131-147
15628124-1	2004	A chiral selector, mono(6A-N-allylamino-6A-deoxy)permethylated beta-cyclodextrin, was synthesized through a facile synthetic route and chemically immobilized onto porous silica gel via hydrosilylation to afford a cyclodextrin based chiral stationary phase MeCD-CSP.	Cyclodextrins	68-80	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	261-264
15136766-0	2004	Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles.	Cyclodextrins	96-108	transferrin	Mus musculus	74-85
15388640-7	2004	Furthermore, cholesterol loading of ECs by either the cholesterol-cyclodextrin complex or caveolin-1 overexpression inhibited OxPAPC induction of IL-8.	Cyclodextrins	66-78	C-X-C motif chemokine ligand 8	Homo sapiens	146-150
15352020-1	2004	The chiral separation of a substituted imidazole p38 MAP kinase inhibitor and its intermediates was investigated using capillary electrophoresis (CE) with various sulfated cyclodextrins.	Cyclodextrins	172-185	mitogen-activated protein kinase 14	Homo sapiens	49-52
15648271-0	2004	Effects of hydrophilic cyclodextrins on aggregation of recombinant human growth hormone.	Cyclodextrins	23-36	growth hormone 1	Homo sapiens	73-87
15382145-3	2004	Agents that affect microfilaments and modulate membrane levels of cholesterol by cyclodextrin were used to distinguish between the raft-mediated and non-raft-related associations of the Pgp.	Cyclodextrins	81-93	phosphoglycolate phosphatase	Homo sapiens	186-189
14688350-8	2004	Extraction of cell surface cholesterol via cyclodextrin treatment of the cells inhibited CFTR entry into rafts.	Cyclodextrins	43-55	CF transmembrane conductance regulator	Canis lupus familiaris	89-93
15044473-1	2004	Cyclodextrins (CDs), a series of hollow cyclic glucosaccharides, can reversibly block molecular permeation through channels formed by connexin-32 and/or connexin-26 reconstituted into liposomes.	Cyclodextrins	0-13	gap junction protein beta 1	Homo sapiens	134-145
15044473-1	2004	Cyclodextrins (CDs), a series of hollow cyclic glucosaccharides, can reversibly block molecular permeation through channels formed by connexin-32 and/or connexin-26 reconstituted into liposomes.	Cyclodextrins	0-13	gap junction protein beta 2	Homo sapiens	153-164
15136724-7	2004	Disruption of caveolae with cyclodextrin prevented the albumin-induced increase in transendothelial flux of (125)I-MPO.	Cyclodextrins	28-40	myeloperoxidase	Homo sapiens	115-118
15058978-1	2004	Novel mesoporous organic-inorganic hybrid silicas containing covalently bound cyclodextrins have been synthesized by a simple, surfactant-free sol-gel route and are shown to have high BET surface areas and narrow pore-size distributions.	Cyclodextrins	78-91	delta/notch like EGF repeat containing	Homo sapiens	184-187
14734645-7	2004	Conditions that selectively deplete plasma membrane lipid raft cholesterol, such as incorporation of 7-ketocholesterol or rapid exposure to cyclodextrins, block apoA-1 binding to these domains but also inhibit cholesterol efflux from the major, slow pool.	Cyclodextrins	140-153	apolipoprotein A1	Homo sapiens	161-167
15017384-4	2004	Removal of cholesterol in OCL via high-density lipoprotein or cyclodextrin treatment dose-dependently induced apoptosis, with actin disruption, nuclear condensation and caspase-3 activation.	Cyclodextrins	62-74	caspase 3	Mus musculus	169-178
15017384-6	2004	Furthermore, cyclodextrin treatment substantially suppressed essential M-CSF and RANKL-induced survival signaling pathways via Akt, mTOR and S6K.	Cyclodextrins	13-25	colony stimulating factor 1 (macrophage)	Mus musculus	71-76
15017384-6	2004	Furthermore, cyclodextrin treatment substantially suppressed essential M-CSF and RANKL-induced survival signaling pathways via Akt, mTOR and S6K.	Cyclodextrins	13-25	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	81-86
15017384-6	2004	Furthermore, cyclodextrin treatment substantially suppressed essential M-CSF and RANKL-induced survival signaling pathways via Akt, mTOR and S6K.	Cyclodextrins	13-25	thymoma viral proto-oncogene 1	Mus musculus	127-130
15017384-6	2004	Furthermore, cyclodextrin treatment substantially suppressed essential M-CSF and RANKL-induced survival signaling pathways via Akt, mTOR and S6K.	Cyclodextrins	13-25	mechanistic target of rapamycin kinase	Mus musculus	132-136
15017384-6	2004	Furthermore, cyclodextrin treatment substantially suppressed essential M-CSF and RANKL-induced survival signaling pathways via Akt, mTOR and S6K.	Cyclodextrins	13-25	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	141-144
15044473-1	2004	Cyclodextrins (CDs), a series of hollow cyclic glucosaccharides, can reversibly block molecular permeation through channels formed by connexin-32 and/or connexin-26 reconstituted into liposomes.	Cyclodextrins	15-18	gap junction protein beta 1	Homo sapiens	134-145
15044473-1	2004	Cyclodextrins (CDs), a series of hollow cyclic glucosaccharides, can reversibly block molecular permeation through channels formed by connexin-32 and/or connexin-26 reconstituted into liposomes.	Cyclodextrins	15-18	gap junction protein beta 2	Homo sapiens	153-164
15001562-4	2004	Conversely, cholesterol depletion using cyclodextrin renders cells more vulnerable to the cytotoxic effects of the Abeta-soluble oligomers.	Cyclodextrins	40-52	amyloid beta precursor protein	Homo sapiens	115-120
14967816-4	2004	Treatment of lipid-loaded J774 cells with cyclodextrin or HDL to promote cellular sterol efflux was associated with an increase in SR-BI expression.	Cyclodextrins	42-54	scavenger receptor class B, member 1	Mus musculus	131-136
14695837-0	2004	Cyclodextrin-derived diorganyl tellurides as glutathione peroxidase mimics and inhibitors of thioredoxin reductase and cancer cell growth.	Cyclodextrins	0-12	thioredoxin	Homo sapiens	93-104
14624625-2	2003	Here, we report the development of a transferrin-modified, cyclodextrin polymer-based gene delivery system.	Cyclodextrins	59-71	transferrin	Homo sapiens	37-48
14695837-6	2004	The cyclodextrin derivatives were also evaluated for their capacity to inhibit thioredoxin reductase/thioredoxin and cancer cell growth in culture.	Cyclodextrins	4-16	peroxiredoxin 5	Homo sapiens	79-100
14695837-6	2004	The cyclodextrin derivatives were also evaluated for their capacity to inhibit thioredoxin reductase/thioredoxin and cancer cell growth in culture.	Cyclodextrins	4-16	thioredoxin	Homo sapiens	79-90
14703837-0	2003	A facile synthesis of novel cyclodextrin derivatives incorporating one beta-(1,4)-glucosidic bond and their unique inclusion ability.	Cyclodextrins	28-40	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	71-80
14624625-5	2003	The transferrin conjugate retains high receptor binding and self-assembles with the nanoparticles by adamantane (host) and particle surface cyclodextrin (guest) inclusion complex formation.	Cyclodextrins	140-152	transferrin	Homo sapiens	4-15
12882150-4	2003	The combination of fungal elicitor plus cyclodextrin was the most effective elicitor treatment, followed by methyl jasmonate plus cyclodextrin in inducing sesquiterpenes and LOX metabolites.	Cyclodextrins	40-52	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	174-177
12731028-0	2003	Determination of enantiomeric purity of a novel COX-2 anti-inflammatory drug by capillary electrophoresis using single and dual cyclodextrin systems.	Cyclodextrins	128-140	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
12591922-8	2003	First, we used cyclodextrins to measure the arrival of LDL cholesterol at the plasma membrane and found that the arrival of LDL cholesterol in a cyclodextrin-accessible pool was significantly delayed in NPC1 cells.	Cyclodextrins	15-28	NPC intracellular cholesterol transporter 1	Cricetulus griseus	203-207
12591922-8	2003	First, we used cyclodextrins to measure the arrival of LDL cholesterol at the plasma membrane and found that the arrival of LDL cholesterol in a cyclodextrin-accessible pool was significantly delayed in NPC1 cells.	Cyclodextrins	15-27	NPC intracellular cholesterol transporter 1	Cricetulus griseus	203-207
12833291-6	2003	Furthermore, the particular structures of L 1 and L 2, characterised by the presence of P(III) units lying close to the cavity entrance, lead upon complexation to complexes whereby the first coordination sphere is partly entrapped in the cyclodextrin.	Cyclodextrins	238-250	L1 cell adhesion molecule	Homo sapiens	42-53
12833291-8	2003	The chelate complex [Ag(L 1)]BF(4) reacts with acetonitrile in excess to afford a mixture of two equilibrating complexes, [Ag(acetonitrile)(L 1)]BF(4) and [Ag(acetonitrile)(2)(L 1)]BF(4), whose coordinated nitriles lie inside the cyclodextrin cavity.	Cyclodextrins	230-242	L1 cell adhesion molecule	Homo sapiens	140-143
12833291-8	2003	The chelate complex [Ag(L 1)]BF(4) reacts with acetonitrile in excess to afford a mixture of two equilibrating complexes, [Ag(acetonitrile)(L 1)]BF(4) and [Ag(acetonitrile)(2)(L 1)]BF(4), whose coordinated nitriles lie inside the cyclodextrin cavity.	Cyclodextrins	230-242	L1 cell adhesion molecule	Homo sapiens	140-143
12834341-0	2003	Cholesterol-dependent association of caveolin-1 with the transducin alpha subunit in bovine photoreceptor rod outer segments: disruption by cyclodextrin and guanosine 5"-O-(3-thiotriphosphate).	Cyclodextrins	140-152	caveolin 1	Bos taurus	37-47
12882150-4	2003	The combination of fungal elicitor plus cyclodextrin was the most effective elicitor treatment, followed by methyl jasmonate plus cyclodextrin in inducing sesquiterpenes and LOX metabolites.	Cyclodextrins	130-142	probable linoleate 9S-lipoxygenase 5	Solanum tuberosum	174-177
12587126-7	2003	The results showed that DOCK 4.0.1 offers a better correlation in terms of orientation of molecules inside the cyclodextrin cavity and also in terms of docking scores.	Cyclodextrins	111-123	dedicator of cytokinesis 4	Homo sapiens	24-30
12102655-6	2002	Consistent with this hypothesis were the following findings: (i) increasing the amount of non-esterified cholesterol in LDL with cyclodextrin increased, and decreasing its amount decreased, the binding of CRP to LDL; (ii) modification of non-esterified cholesterol in LDL by cholesterol oxidase decreased the binding of CRP to LDL; and (iii) CRP bound to purified non-esterified cholesterol.	Cyclodextrins	129-141	C-reactive protein	Homo sapiens	205-208
12586368-1	2003	We compared the inhibitory effect of various cyclodextrins (CyDs) on P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2) function and examined the contribution of cholesterol to the inhibitory effect of 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CyD) on the efflux activity of the function in Caco-2 cell monolayers.	Cyclodextrins	60-64	ATP binding cassette subfamily B member 1	Homo sapiens	69-83
12586368-1	2003	We compared the inhibitory effect of various cyclodextrins (CyDs) on P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2) function and examined the contribution of cholesterol to the inhibitory effect of 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CyD) on the efflux activity of the function in Caco-2 cell monolayers.	Cyclodextrins	60-64	ATP binding cassette subfamily B member 1	Homo sapiens	85-89
12526823-0	2003	Feeding liquid, non-ionic surfactant and cyclodextrin affect the properties of insulin-loaded poly(lactide-co-glycolide) microspheres prepared by spray-drying.	Cyclodextrins	41-53	insulin	Bos taurus	79-86
12586368-1	2003	We compared the inhibitory effect of various cyclodextrins (CyDs) on P-glycoprotein (P-gp) and multidrug resistance-associated protein 2 (MRP2) function and examined the contribution of cholesterol to the inhibitory effect of 2,6-di-O-methyl-beta-cyclodextrin (DM-beta-CyD) on the efflux activity of the function in Caco-2 cell monolayers.	Cyclodextrins	60-64	ATP binding cassette subfamily C member 2	Homo sapiens	95-136
12529448-6	2003	Dissociation of the VEGFR-2/caveolin-1 complex by VEGF or cyclodextrin led to a PP2-sensitive phosphorylation of caveolin-1 on tyrosine 14, suggesting the participation of Src family kinases in this process.	Cyclodextrins	58-70	kinase insert domain receptor	Homo sapiens	20-27
12529448-6	2003	Dissociation of the VEGFR-2/caveolin-1 complex by VEGF or cyclodextrin led to a PP2-sensitive phosphorylation of caveolin-1 on tyrosine 14, suggesting the participation of Src family kinases in this process.	Cyclodextrins	58-70	caveolin 1	Homo sapiens	28-38
12529448-6	2003	Dissociation of the VEGFR-2/caveolin-1 complex by VEGF or cyclodextrin led to a PP2-sensitive phosphorylation of caveolin-1 on tyrosine 14, suggesting the participation of Src family kinases in this process.	Cyclodextrins	58-70	vascular endothelial growth factor A	Homo sapiens	20-24
12529448-6	2003	Dissociation of the VEGFR-2/caveolin-1 complex by VEGF or cyclodextrin led to a PP2-sensitive phosphorylation of caveolin-1 on tyrosine 14, suggesting the participation of Src family kinases in this process.	Cyclodextrins	58-70	caveolin 1	Homo sapiens	113-138
12055092-2	2002	BMP2 endocytosis was inhibited chemically with polyethylene glycol-50 (PEG-Chol) and cyclodextrin and mechanically by mild hyposmotic treatment.	Cyclodextrins	85-97	bone morphogenetic protein 2	Homo sapiens	0-4
12177179-7	2002	Tritium-labeled AC delivered to intact CHO cells as a cyclodextrin complex was shown to photoaffinity label several discrete polypeptides, including caveolin-1.	Cyclodextrins	54-66	caveolin-1	Cricetulus griseus	149-159
12372346-4	2002	The EGF-dependent phosphorylation of caveolin-1 was observed at low temperatures (4 degrees C) and was enhanced by caveolae-disrupting agents (cyclodextrin), suggesting that this EGF-dependent system is in a low temperature-stable arrangement that allows for their interaction under conditions where mobility in the membrane is altered.	Cyclodextrins	143-155	caveolin 1	Homo sapiens	37-47
12070330-0	2002	Structural basis for cyclodextrins" suppression of human growth hormone aggregation.	Cyclodextrins	21-34	growth hormone 1	Homo sapiens	57-71
12062649-10	2002	Finally, the complexation of insulin with met beta CD was characterized in aqueous media by (1)H NMR chemical shift displacements of assignable aromatic protons of specific amino acids upon the addition of the cyclodextrin, as well as by ESI-MS, since additional m/z peaks, which were attributed to insulin-met beta CD complex, were detected.	Cyclodextrins	210-222	insulin	Homo sapiens	29-36
12070330-6	2002	Here we investigate the interactions between human growth hormone (hGH) and different CDs at low pH.	Cyclodextrins	86-89	growth hormone 1	Homo sapiens	51-65
12179991-0	2002	Enantioseparation of novel COX-2 anti-inflammatory drugs by capillary electrophoresis using single and dual cyclodextrin systems.	Cyclodextrins	108-120	prostaglandin-endoperoxide synthase 2	Homo sapiens	27-32
11765082-2	2001	On the basis of the fluorescence enhancement, a new RP-HPLC method for detecting aflatoxins B1, B2, G1, G2 and M1 was developed using cyclodextrins directly dissolved in the LC eluent.	Cyclodextrins	134-147	membrane spanning 4-domains A1	Homo sapiens	92-113
11861661-3	2002	This flux spared NPC and amphiphile-treated cells from disruption by the extraction of their plasma membrane cholesterol with cyclodextrin.	Cyclodextrins	126-138	NPC intracellular cholesterol transporter 1	Homo sapiens	17-20
11878189-13	2002	These results demonstrate the usefulness of cyclodextrin in the formulation of the CDSs of TRH analogs.	Cyclodextrins	44-56	thyrotropin releasing hormone	Mus musculus	91-94
11817723-3	2002	The physical and chemical properties of the CD polymers were characterized by IR, solid state 13C NMR, TGA, and DSC, respectively.	Cyclodextrins	44-46	desmocollin 3	Homo sapiens	112-115
11751579-4	2002	We report that, in liver-derived cells lacking caveolae, autophosphorylation of the endogenous IR is dependent on raft lipids, being compromised by acute cyclodextrin-mediated cholesterol depletion or by antibody clustering of glycosphingolipids.	Cyclodextrins	154-166	insulin receptor	Homo sapiens	95-97
12011978-1	2002	Cyclodextrin encapsulated beta-estradiol and progesterone were used for enhancement of gene delivery using the breast cancer cell line Sk-Br-3.	Cyclodextrins	0-12	potassium calcium-activated channel subfamily N member 3	Homo sapiens	135-142
11817723-3	2002	The physical and chemical properties of the CD polymers were characterized by IR, solid state 13C NMR, TGA, and DSC, respectively.	Cyclodextrins	44-46	T-box transcription factor 1	Homo sapiens	103-106
11936765-2	2002	Whereas the enantiomers of the acidic DHPs could be separated with neutral CDs the enantiomers of the neutral DHPs were only baseline separated using the sulfobutylether substituted beta-CD.	Cyclodextrins	75-78	deoxyhypusine synthase	Homo sapiens	38-42
11936765-4	2002	The racemates of the DHPs characterized by a secondary or tertiary amine function in the carboxylate side chain could be resolved by using either the neutral gamma-CD or negative charged CDs.	Cyclodextrins	187-190	deoxyhypusine synthase	Homo sapiens	21-25
11755209-0	2001	Pharmacological in vitro evaluation of new substance P-cyclodextrin derivatives designed to drug targeting towards NK1-receptor bearing cells.	Cyclodextrins	55-67	tachykinin receptor 1	Rattus norvegicus	115-127
11309399-7	2001	The conditioned media from cyclodextrin-pretreated, ABCA1-expressing cells readily promoted cholesterol efflux when added to fresh cells not expressing ABCA1, indicating that cholesterol efflux can be dissociated from phospholipid efflux.	Cyclodextrins	27-39	ATP binding cassette subfamily A member 1	Homo sapiens	52-57
11749800-4	2001	The effect of SDC in combination with CD on the leucine aminopeptidase (LAP) activity in the nasal mucosa was observed.	Cyclodextrins	38-40	leucine aminopeptidase 3	Rattus norvegicus	48-70
11749800-4	2001	The effect of SDC in combination with CD on the leucine aminopeptidase (LAP) activity in the nasal mucosa was observed.	Cyclodextrins	38-40	leucine aminopeptidase 3	Rattus norvegicus	72-75
11590226-15	2001	In contrast, if the cells were depleted of cholesterol by incubating them with lovastatin and cyclodextrin, the mature forms of SREBP-1 and SREBP-2 were increased, as were mRNA levels for the sterol-responsive genes.	Cyclodextrins	94-106	sterol regulatory element binding transcription factor 1	Homo sapiens	128-135
11590226-15	2001	In contrast, if the cells were depleted of cholesterol by incubating them with lovastatin and cyclodextrin, the mature forms of SREBP-1 and SREBP-2 were increased, as were mRNA levels for the sterol-responsive genes.	Cyclodextrins	94-106	sterol regulatory element binding transcription factor 2	Homo sapiens	140-147
11668087-6	2001	ERK1/2 phosphorylation was suppressed by an inhibitor of tyrosine phosphorylation (genestein), cholesterol-binding reagents (filipin or cyclodextrin), or inhibitors of ROS (diphenyleneiodonium, N-acetylcysteine, or catalase), suggesting a role for both membrane cholesterol and ROS in ERK1/2 activation.	Cyclodextrins	136-148	mitogen-activated protein kinase 3	Bos taurus	0-6
11697741-3	2001	Among the three kinds of cyclodextrins tested, beta-CD induced significant changes in the UV absorption spectrum of gurmarin that were characteristic of those found in the inclusion complex formation of tyrosine and tryptophan with beta-CD.	Cyclodextrins	25-38	beta-carotene oxygenase 1	Mus musculus	47-54
11697741-3	2001	Among the three kinds of cyclodextrins tested, beta-CD induced significant changes in the UV absorption spectrum of gurmarin that were characteristic of those found in the inclusion complex formation of tyrosine and tryptophan with beta-CD.	Cyclodextrins	25-38	beta-carotene oxygenase 1	Mus musculus	232-239
11309399-6	2001	After using cyclodextrin preincubation to deplete cellular cholesterol, ABCA1-mediated cholesterol efflux was abolished but phospholipid efflux and the binding of apoA-I were unaffected.	Cyclodextrins	12-24	ATP binding cassette subfamily A member 1	Homo sapiens	72-77
11309399-6	2001	After using cyclodextrin preincubation to deplete cellular cholesterol, ABCA1-mediated cholesterol efflux was abolished but phospholipid efflux and the binding of apoA-I were unaffected.	Cyclodextrins	12-24	apolipoprotein A1	Homo sapiens	163-169
11309399-7	2001	The conditioned media from cyclodextrin-pretreated, ABCA1-expressing cells readily promoted cholesterol efflux when added to fresh cells not expressing ABCA1, indicating that cholesterol efflux can be dissociated from phospholipid efflux.	Cyclodextrins	27-39	ATP binding cassette subfamily A member 1	Homo sapiens	152-157
11114301-4	2001	Disruption of membrane rafts by removal of cholesterol with cyclodextrin blocked CD47-induced actin polymerization, and mutant forms of CD47 that localized poorly to rafts failed to effect cytoskeletal rearrangement.	Cyclodextrins	60-72	CD47 molecule	Homo sapiens	81-85
11278358-8	2001	In contrast, cyclodextrin known to deplete plasma membrane of cholesterol and to disrupt caveolae induced only a disappearance of eNOS from the plasma membrane that was not associated with decreased agonist-induced citrulline and cGMP formation.	Cyclodextrins	13-25	nitric oxide synthase 3	Homo sapiens	130-134
14727890-5	2001	Cyclodextrins can increase the CsA solubility, but alphaCD was more effective than HPbetaCD.	Cyclodextrins	0-13	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	31-34
11180297-1	2001	Enantiomeric separations by cyclodextrin-modified capillary electrophoresis of chiral carbamates containing a 4-substituted imidazole heterocycle, pharmacologically acting as histamine H3-receptor antagonists, were carried out.	Cyclodextrins	28-40	histamine receptor H3	Homo sapiens	175-196
11113453-3	2000	Chemically denatured citrate synthase was refolded and completely recovered it"s enzymatic activity after dilution with polyoxyethylenesorbitan buffer followed by cycloamylose treatment.	Cyclodextrins	163-175	citrate synthase	Homo sapiens	21-37
11113453-5	2000	Cycloamylose also promoted the refolding of denatured carbonic anhydrase B and denatured lysozyme of a reduced form.	Cyclodextrins	0-12	carbonic anhydrase 2	Homo sapiens	54-74
11128592-1	2000	The possibility that cyclotrikis-(1-->6)-[alpha-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl] (CGM6) forms inclusion complexes, like cycloamyloses (cyclodextrins), was investigated by means of electrospray mass spectrometry and fluorescence spectroscopy.	Cyclodextrins	141-154	CEA cell adhesion molecule 8	Homo sapiens	103-107
11128592-1	2000	The possibility that cyclotrikis-(1-->6)-[alpha-D-glucopyranosyl-(1-->4)-beta-D-glucopyranosyl] (CGM6) forms inclusion complexes, like cycloamyloses (cyclodextrins), was investigated by means of electrospray mass spectrometry and fluorescence spectroscopy.	Cyclodextrins	156-169	CEA cell adhesion molecule 8	Homo sapiens	103-107
10664478-4	2000	To this end, the interaction of ABPP with several cyclodextrin derivatives-alpha-, beta-, gamma- and hydroxypropyl-beta-cyclodextrin with a degree of substitution 2.7 (HPbetaCD) was studied and the effect of the complexation process on the water solubility of the drug was evaluated.	Cyclodextrins	50-62	amyloid beta precursor protein	Homo sapiens	32-36
11271478-4	2000	The racemates of the DHP bearing a secondary or tertiary amine function in the side chain at position 3 could be separated by using either the neutral gamma-CD or negatively charged CDs.	Cyclodextrins	182-185	dihydropyrimidinase	Homo sapiens	21-24
11013311-2	2000	Chol depletion of CHO-2B cells by treatment with methyl-beta-cyclodextrin (5 mm) resulted in the inhibition of the release of arachidonic acid whereas the restoration of the level by Chol-loaded cyclodextrin relieved inhibition.	Cyclodextrins	61-73	EBP cholestenol delta-isomerase	Homo sapiens	18-23
11018470-9	2000	Disruption of cholesterol-rich DIFs with digitonin, cyclodextrin or filipin potentiated activation of PLD by TPA.	Cyclodextrins	52-64	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	102-105
10938082-11	2000	Disruption of cell membrane caveolae by cyclodextrin treatment reduced the SR-BI-catalyzed incorporation of py-SM, suggesting that intact caveolae are necessary for the phospholipid uptake.	Cyclodextrins	40-52	scavenger receptor class B member 1	Homo sapiens	75-80
10849854-6	2000	The FBR achieved high productivity, reaching in only 4 min of residence time the same amount of CDs normally achieved in a batch reactor with free enzyme after 24 h of reaction, namely, 10.4 mM beta-CD and 2.3 mM gamma-CD.	Cyclodextrins	96-99	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	194-207
10559881-4	1999	Strikingly, the inhibitory effect of CavDGV on H-Ras signalling was completely reversed by replenishing cell membranes with cholesterol and was mimicked by cyclodextrin treatment, which depletes membrane cholesterol.	Cyclodextrins	156-168	HRas proto-oncogene, GTPase	Homo sapiens	47-52
11126872-1	2000	The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs.	Cyclodextrins	148-161	angiotensinogen	Homo sapiens	76-79
11126872-1	2000	The enantiomers of aminoglutethimide [2-(p-aminophenyl)-2-ethylglutarimide, AGT] can be resolved in CE using all of three most commonly used native cyclodextrins (CD): alpha-, beta-, and gamma-CDs.	Cyclodextrins	163-165	angiotensinogen	Homo sapiens	76-79
10455198-0	1999	Properties of a cyclodextrin-specific, unusual porin from Klebsiella oxytoca.	Cyclodextrins	16-28	outer membrane porin, OprD family	Klebsiella oxytoca	47-52
10455198-12	1999	CymA thus is an atypical porin with novel properties specialized to transfer cyclodextrins across the outer membrane.	Cyclodextrins	77-90	outer membrane porin, OprD family	Klebsiella oxytoca	25-30
10542298-9	1999	Cyclodextrin also depleted caveolae of cholesterol and caused eNOS and caveolin to translocate from caveolae.	Cyclodextrins	0-12	nitric oxide synthase 3	Homo sapiens	62-66
10704119-0	1999	Modelling of conditions for the enantiomeric separation of beta2-adrenergic sympathicomimetics by capillary electrophoresis using cyclodextrins as chiral selectors in a polyethylene glycol gel.	Cyclodextrins	130-143	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	59-64
10704119-1	1999	A two-factor central composite design was used to determine a mathematical model for prediction of the optimal conditions for the separation of the enantiomers of some widely used beta2-sympathicomimetic drugs (beta2-agonists) by capillary electrophoresis using cyclodextrins (CD) as a chiral selector in a polyethylene glycolgel.	Cyclodextrins	262-275	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	180-185
10704119-1	1999	A two-factor central composite design was used to determine a mathematical model for prediction of the optimal conditions for the separation of the enantiomers of some widely used beta2-sympathicomimetic drugs (beta2-agonists) by capillary electrophoresis using cyclodextrins (CD) as a chiral selector in a polyethylene glycolgel.	Cyclodextrins	262-275	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	211-216
10704119-1	1999	A two-factor central composite design was used to determine a mathematical model for prediction of the optimal conditions for the separation of the enantiomers of some widely used beta2-sympathicomimetic drugs (beta2-agonists) by capillary electrophoresis using cyclodextrins (CD) as a chiral selector in a polyethylene glycolgel.	Cyclodextrins	277-279	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	180-185
10704119-1	1999	A two-factor central composite design was used to determine a mathematical model for prediction of the optimal conditions for the separation of the enantiomers of some widely used beta2-sympathicomimetic drugs (beta2-agonists) by capillary electrophoresis using cyclodextrins (CD) as a chiral selector in a polyethylene glycolgel.	Cyclodextrins	277-279	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	211-216
9813079-7	1998	Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus.	Cyclodextrins	0-12	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	37-41
9813079-7	1998	Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus.	Cyclodextrins	0-12	LOW QUALITY PROTEIN: oxysterol-binding protein 1	Cricetulus griseus	96-100
9677422-11	1998	This suggests that the binding site of the cyclodextrins is important for its holding of a cleaved substrate, which enables the multiple attack mechanism of beta-amylase.	Cyclodextrins	43-56	beta-amylase	Glycine max	157-169
8766694-6	1996	Cyclodextrin-induced insulin dissociation is also observed at pH 7.4.	Cyclodextrins	0-12	insulin	Bos taurus	21-28
9629899-5	1998	The patterns of apoB-Lp in IEF with the CDs appeared to differ in some sera.	Cyclodextrins	40-43	apolipoprotein B	Homo sapiens	16-20
9270972-4	1997	Prolonged daily (4 d or more) administration of 0.5% (3.5 mM) cyclodextrin with medium containing 10% fetal bovine serum increased the secretion of nascent apoB from 5-10% (control) to 17-28% and cellular undegraded apoB from 15-20% (control) to 25-31% of apoB synthesized, respectively.	Cyclodextrins	62-74	apolipoprotein B	Homo sapiens	216-220
9270972-5	1997	Subsequent administration of cyclodextrin solubilized cholesterol (10-40 micrograms) for only 3 h reversed the cyclodextrin-mediated increase in apoB secretion.	Cyclodextrins	29-41	apolipoprotein B	Homo sapiens	145-149
9270972-5	1997	Subsequent administration of cyclodextrin solubilized cholesterol (10-40 micrograms) for only 3 h reversed the cyclodextrin-mediated increase in apoB secretion.	Cyclodextrins	111-123	apolipoprotein B	Homo sapiens	145-149
9270972-8	1997	However, prolonged (15 d) administration of cyclodextrin was shown to increase the cellular free cholesterol concentration by 25-41%, reduce the cellular triglyceride concentration by 59%, and increase apoB secretion 3- to 4-fold, without affecting the cellular cholesteryl ester concentration.	Cyclodextrins	44-56	apolipoprotein B	Homo sapiens	202-206
9270972-9	1997	In comparison, 14-d treatment with cyclodextrin-solubilized cholesterol (20 micrograms/mL) followed by 1-d equilibration without cholesterol was shown to increase the cellular free cholesterol and cholesteryl ester concentrations by 76% and 10-fold, respectively, although apoB secretion was not affected.	Cyclodextrins	35-47	apolipoprotein B	Homo sapiens	273-277
9270972-10	1997	It is hypothesized that chronic daily administration of 0.5% cyclodextrin increased the cellular cholesterol concentration and flux in discrete putative regulatory compartments, which "shielded" nascent apoB from rapid proteolysis and facilitated apoB secretion.	Cyclodextrins	61-73	apolipoprotein B	Homo sapiens	203-207
9270972-10	1997	It is hypothesized that chronic daily administration of 0.5% cyclodextrin increased the cellular cholesterol concentration and flux in discrete putative regulatory compartments, which "shielded" nascent apoB from rapid proteolysis and facilitated apoB secretion.	Cyclodextrins	61-73	apolipoprotein B	Homo sapiens	247-251
9270972-11	1997	In conclusion, cyclodextrin was used independently and in combination with cholesterol or oleate to modulate apoB proteolysis and secretion.	Cyclodextrins	15-27	apolipoprotein B	Homo sapiens	109-113
9249950-1	1997	Aqueous solutions of cyclodextrins and inorganic metaphosphate at pH 4, upon drying and subsequent warming, produce mixtures of isomeric monophosphate esters which are amenable to separation by anion-exchange chromatography.	Cyclodextrins	21-34	prolyl 4-hydroxylase, transmembrane	Homo sapiens	66-70
9295158-0	1997	Kinetic characteristics of the enzymatic conversion in presence of cyclodextrins: study of the oxidation of polyunsaturated fatty acids by lipoxygenase.	Cyclodextrins	67-80	linoleate 9S-lipoxygenase-4	Glycine max	139-151
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Cyclodextrins	65-68	linoleate 9S-lipoxygenase-4	Glycine max	84-96
9295158-2	1997	In order to evaluate the behaviour of the enzymes in presence of CDs a study of the lipoxygenase (LOX)-catalyzed oxidation of polyunsaturated fatty acids (PUFA) as model reaction has been carried out.	Cyclodextrins	65-68	linoleate 9S-lipoxygenase-4	Glycine max	98-101
9295158-12	1997	CD was shown to slow down the reaction rate of LOX, specifically due to the increase of Km, Vmax remaining unchanged.	Cyclodextrins	0-2	linoleate 9S-lipoxygenase-4	Glycine max	47-50
9295158-16	1997	From the observation of the reaction progress curves in the conditions of the CD assay, we have studied some characteristic parameters of the oxidation of PUFA by LOX in this new medium, such as enzymatic activity, duration of linear product accumulation and the lag phase.	Cyclodextrins	78-80	linoleate 9S-lipoxygenase-4	Glycine max	163-166
9270972-0	1997	Use of cyclodextrin to deliver lipids and to modulate apolipoprotein B-100 production in HepG2 cells.	Cyclodextrins	7-19	apolipoprotein B	Homo sapiens	54-74
9270972-3	1997	Three-hour treatment with cyclodextrin-solubilized oleate (0.2 mM) increased secreted apoB from 4% (control cells) to 32% and cellular undegraded apoB from 15% (control cells to 64% of apoB synthesized, which is consistent with earlier studies using bovine serum albumin to complex exogenous oleate.	Cyclodextrins	26-38	apolipoprotein B	Homo sapiens	86-90
9270972-3	1997	Three-hour treatment with cyclodextrin-solubilized oleate (0.2 mM) increased secreted apoB from 4% (control cells) to 32% and cellular undegraded apoB from 15% (control cells to 64% of apoB synthesized, which is consistent with earlier studies using bovine serum albumin to complex exogenous oleate.	Cyclodextrins	26-38	apolipoprotein B	Homo sapiens	146-150
9270972-3	1997	Three-hour treatment with cyclodextrin-solubilized oleate (0.2 mM) increased secreted apoB from 4% (control cells) to 32% and cellular undegraded apoB from 15% (control cells to 64% of apoB synthesized, which is consistent with earlier studies using bovine serum albumin to complex exogenous oleate.	Cyclodextrins	26-38	apolipoprotein B	Homo sapiens	146-150
9270972-4	1997	Prolonged daily (4 d or more) administration of 0.5% (3.5 mM) cyclodextrin with medium containing 10% fetal bovine serum increased the secretion of nascent apoB from 5-10% (control) to 17-28% and cellular undegraded apoB from 15-20% (control) to 25-31% of apoB synthesized, respectively.	Cyclodextrins	62-74	apolipoprotein B	Homo sapiens	156-160
9270972-4	1997	Prolonged daily (4 d or more) administration of 0.5% (3.5 mM) cyclodextrin with medium containing 10% fetal bovine serum increased the secretion of nascent apoB from 5-10% (control) to 17-28% and cellular undegraded apoB from 15-20% (control) to 25-31% of apoB synthesized, respectively.	Cyclodextrins	62-74	apolipoprotein B	Homo sapiens	216-220
8921745-0	1996	Interaction of beta 2-adrenoceptor agonists with native cyclodextrins: application to the development of chiral assays for terbutaline.	Cyclodextrins	56-69	adrenoceptor beta 2	Homo sapiens	15-34
8921745-1	1996	The enantioselectivity of the complexation between beta 2-adrenoceptor agonists of different structural types and native cyclodextrins (alpha, beta and gamma-CDs) has been examined by including CDs as chiral modifiers in high pressure liquid chromatography (HPLC) and in capillary zone electrophoresis (CZE).	Cyclodextrins	121-134	adrenoceptor beta 2	Homo sapiens	51-70
8631951-8	1996	CAB is unable to refold from the detergent-complexed state, but folding can be induced by introduction of a cyclodextrin, which strips the detergent away from the protein.	Cyclodextrins	108-120	carbonic anhydrase 2	Homo sapiens	0-3
9010691-10	1996	Compared to conventional PGE1-cyclodextrin infusions given over 2 h, a clearly prolonged increase in perfusion of the affected limb after LIPO-PGE1 was demonstrated.	Cyclodextrins	30-42	high mobility group AT-hook 2	Homo sapiens	138-147
8587046-0	1995	Improvement of nasal bioavailability of luteinizing hormone-releasing hormone agonist, buserelin, by cyclodextrin derivatives in rats.	Cyclodextrins	101-113	gonadotropin releasing hormone 1	Rattus norvegicus	40-77
8545599-5	1995	Potentiometric alpha, beta and gamma cyclodextrin-based electrodes selectively sense NH4+, NMe4+ and NEt4+ ions respectively.	Cyclodextrins	37-49	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	91-95
7577972-0	1995	Expression of the human oxytocin receptor in baculovirus-infected insect cells: high-affinity binding is induced by a cholesterol-cyclodextrin complex.	Cyclodextrins	130-142	oxytocin receptor	Homo sapiens	24-41
8545599-5	1995	Potentiometric alpha, beta and gamma cyclodextrin-based electrodes selectively sense NH4+, NMe4+ and NEt4+ ions respectively.	Cyclodextrins	37-49	tetraspanin 5	Homo sapiens	101-105
7736469-3	1995	The resultant fructosylcyclodextrins (Fru-CDs) show increased solubility in water and, in the case of Fru-beta-CD increased ability to solubilize sparingly soluble compounds by inclusion, relative to the parent cyclodextrins.	Cyclodextrins	23-36	zinc finger and BTB domain containing 22	Homo sapiens	38-41
7615524-8	1995	The estimated Vmax values for cyclodextrin-mediated efflux were 3.5-70-fold greater than for HDL3 for the three cell lines.	Cyclodextrins	30-42	high density lipoprotein (HDL) level 3	Mus musculus	93-97
9384768-3	1995	As a result, the C18-coated capillary can produce a separation field similar to that which is generally found in RPLC with the C18 alkyl bonded stationary phase, and the main migration mechanism is thought to be facilitated by the hydrophobic interaction between the solutes and the cyclodextrins (CDs).	Cyclodextrins	283-296	Bardet-Biedl syndrome 9	Homo sapiens	17-20
9384768-3	1995	As a result, the C18-coated capillary can produce a separation field similar to that which is generally found in RPLC with the C18 alkyl bonded stationary phase, and the main migration mechanism is thought to be facilitated by the hydrophobic interaction between the solutes and the cyclodextrins (CDs).	Cyclodextrins	298-301	Bardet-Biedl syndrome 9	Homo sapiens	17-20
7736469-3	1995	The resultant fructosylcyclodextrins (Fru-CDs) show increased solubility in water and, in the case of Fru-beta-CD increased ability to solubilize sparingly soluble compounds by inclusion, relative to the parent cyclodextrins.	Cyclodextrins	23-36	zinc finger and BTB domain containing 22	Homo sapiens	102-105
7736469-4	1995	However, the Fru-CDs have similar abilities to form complexes as their respective parent CDs.	Cyclodextrins	17-20	zinc finger and BTB domain containing 22	Homo sapiens	13-16
1477928-0	1992	Enhancing effect of cyclodextrins on nasal absorption of insulin and its duration in rabbits.	Cyclodextrins	20-33	insulin	Oryctolagus cuniculus	57-64
7899230-3	1994	The effect of cyclodextrins on the rate of degradation of FGG and YGGFL by leucine aminopeptidase (LAP) and of GGF by carboxypeptidase A (CPA) was monitored.	Cyclodextrins	14-27	fibrinogen gamma chain	Ovis aries	58-61
8194069-0	1994	Binding geometry, stoichiometry, and thermodynamics of cyclomalto-oligosaccharide (cyclodextrin) inclusion complex formation with chlorogenic acid, the major substrate of apple polyphenol oxidase.	Cyclodextrins	55-81	polyphenol oxidase, chloroplastic	Malus domestica	177-195
8194069-0	1994	Binding geometry, stoichiometry, and thermodynamics of cyclomalto-oligosaccharide (cyclodextrin) inclusion complex formation with chlorogenic acid, the major substrate of apple polyphenol oxidase.	Cyclodextrins	83-95	polyphenol oxidase, chloroplastic	Malus domestica	177-195
8194069-9	1994	These latter findings strongly argue that the mechanism for inhibition of juice browning with cyclodextrins was mainly due to the binding of PPO substrates and not some other means such as enzyme inactivation via sequestration of Cu2+ by CDs.	Cyclodextrins	94-107	polyphenol oxidase, chloroplastic	Malus domestica	141-144
8276424-0	1993	Evidence for beta-galactosidase catalyzed hydrolysis of paranitrophenyl-beta-D-galactopyranoside anchored in cyclodextrins.	Cyclodextrins	109-122	galactosidase beta 1	Homo sapiens	13-31
8069577-0	1993	Minimization of shaking-induced formation of insoluble aggregates of insulin by cyclodextrins.	Cyclodextrins	80-93	insulin	Bos taurus	69-76
8069577-10	1993	The efficacy of cyclodextrins in preventing aggregation (% insulin aggregated in parentheses), was: hydroxypropyl-beta- (15) approximately beta- (18) > alpha- (54).	Cyclodextrins	16-29	insulin	Bos taurus	59-66
1477920-2	1992	Enhanced rectal absorption of insulin from hollow-type suppositories containing insulin and cyclodextrins in rabbits.	Cyclodextrins	92-105	insulin	Oryctolagus cuniculus	30-37
7855049-3	1994	Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors.	Cyclodextrins	0-13	renin	Rattus norvegicus	50-55
7855049-3	1994	Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors.	Cyclodextrins	0-13	renin	Rattus norvegicus	118-123
7855049-3	1994	Cyclodextrins (CD) improved the low solubility of renin inhibitors, with beta-CD showing the best ability to dissolve renin inhibitors.	Cyclodextrins	15-17	renin	Rattus norvegicus	50-55
8321831-4	1993	Apparently, the effect of the cyclodextrin derivative on insulin absorption differs between animal species following nasal delivery of insulin/DM beta CD solutions.	Cyclodextrins	30-42	insulin	Oryctolagus cuniculus	57-64
1903659-0	1991	Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin.	Cyclodextrins	85-97	linoleate 9S-lipoxygenase-4	Glycine max	8-20
1409397-9	1992	The cyclodextrins are also capable of dissociating insulin hexamers into smaller aggregates, and this dissociation depends on cyclodextrin structure and concentration.	Cyclodextrins	4-17	insulin	Homo sapiens	51-58
1409397-9	1992	The cyclodextrins are also capable of dissociating insulin hexamers into smaller aggregates, and this dissociation depends on cyclodextrin structure and concentration.	Cyclodextrins	4-16	insulin	Homo sapiens	51-58
1409397-10	1992	Enhancement of insulin diffusivity across nasal membrane through dissociation may provide an additional mechanism for cyclodextrin promotion of nasal insulin absorption.	Cyclodextrins	118-130	insulin	Homo sapiens	15-22
1409397-0	1992	Cyclodextrins as nasal absorption promoters of insulin: mechanistic evaluations.	Cyclodextrins	0-13	insulin	Homo sapiens	47-54
1903659-1	1991	The linoleic or arachidonic acid entrapped in cyclodextrin (alpha, beta or gamma) serves as an excellent substrate for soybean lipoxygenase-1 catalysis.	Cyclodextrins	46-58	linoleate 9S-lipoxygenase-4	Glycine max	127-139
33034456-6	2020	When l-StG was spread on the cyclodextrins, both CD and CPL were enhanced.	Cyclodextrins	29-42	chromosome 6 open reading frame 15	Homo sapiens	7-10
33034456-7	2020	When d-StG was reacted with cyclodextrins, the CD signal decreased while the CPL was enhanced.	Cyclodextrins	28-41	chromosome 6 open reading frame 15	Homo sapiens	7-10
34838360-0	2022	Elucidation of specific binding sites and extraction of toxic Gen X from HSA employing cyclodextrin.	Cyclodextrins	87-99	GEN1 Holliday junction 5' flap endonuclease	Homo sapiens	62-65
34497177-1	2021	The precise understanding of the behaviour of vitamin E (alpha-tocopherol; Toc) complexed with cyclodextrin (CD) additives in aqueous solution is a fundamental issue for further development of their aqua-related biological applications.	Cyclodextrins	95-107	rhomboid 5 homolog 2	Homo sapiens	75-78
34793942-0	2021	Modified cyclodextrin-based nanoparticles mediated delivery of siRNA for Huntingtin gene silencing across an in vitro BBB model.	Cyclodextrins	9-21	huntingtin	Homo sapiens	73-83
34793942-6	2021	Here, we described a novel delivery system based on modified cyclodextrin nanoparticles (CDs) loaded with small interfering RNAs (siRNAs) targeting HTT andcomplexed with the rabies virus glycoprotein(RVG), a BBB-shuttle peptide.	Cyclodextrins	61-73	huntingtin	Homo sapiens	148-151
34397150-3	2021	In this work, we were interested in the ss-cyclodextrin/ferrocene inclusion complex formed on beta-CD monolayers functionalized surfaces.	Cyclodextrins	42-55	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	94-101
34620064-3	2022	The industrial significance of CDs became apparent during the 1970s as scientists started to discover more of CD"s potential in chemical modifications and the formation of inclusion complexes.	Cyclodextrins	31-34	CDP-diacylglycerol synthase 1	Homo sapiens	110-114
34602005-1	2022	A novel cyclodextrin-contained copolymer poly(AAc-co-SA-AC-co-allyl-beta-CD) was synthesized based on the method of redox radical polymerization.	Cyclodextrins	8-20	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	68-75
34523167-1	2021	Host-guest complexes between native cyclodextrins (alpha-, beta- and gamma-CD) and hybrid Lindqvist-type polyoxovanadates (POVs) (V6O13((OCH2)3C-R)2)2- with R=CH2CH3, NO2, CH2OH and NH(BOC) were studied in aqueous solution.	Cyclodextrins	36-49	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	51-78
34805269-0	2021	Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction.	Cyclodextrins	0-13	potassium voltage-gated channel subfamily A member 3	Homo sapiens	67-72
34805269-4	2021	Potential direct, ligand-like CD effects are largely neglected in spite of several recent studies reporting direct interaction between CDs and proteins including AMP-activated protein kinase, beta-amyloid peptides, and alpha-synuclein.	Cyclodextrins	135-138	synuclein alpha	Homo sapiens	219-234
34805269-5	2021	In this study, by using patch-clamp technique, time-resolved quantitation of cholesterol levels and biophysical parameters and applying cholesterol-extracting and non-cholesterol-extracting CDs at 1 and 5 mM concentrations, we provide evidence for a previously unexplored ligand-like, cholesterol-independent current inhibitory effect of CDs on KV1.3, a prototypical voltage-gated potassium channel with pathophysiological relevance in various autoimmune and neurodegenerative disorders.	Cyclodextrins	190-193	potassium voltage-gated channel subfamily A member 3	Homo sapiens	345-350
34805269-5	2021	In this study, by using patch-clamp technique, time-resolved quantitation of cholesterol levels and biophysical parameters and applying cholesterol-extracting and non-cholesterol-extracting CDs at 1 and 5 mM concentrations, we provide evidence for a previously unexplored ligand-like, cholesterol-independent current inhibitory effect of CDs on KV1.3, a prototypical voltage-gated potassium channel with pathophysiological relevance in various autoimmune and neurodegenerative disorders.	Cyclodextrins	338-341	potassium voltage-gated channel subfamily A member 3	Homo sapiens	345-350
34497177-1	2021	The precise understanding of the behaviour of vitamin E (alpha-tocopherol; Toc) complexed with cyclodextrin (CD) additives in aqueous solution is a fundamental issue for further development of their aqua-related biological applications.	Cyclodextrins	109-111	rhomboid 5 homolog 2	Homo sapiens	75-78
34497177-7	2021	A phase solubility study indicated the formation of 1:2 or 1:3 Toc/CD inclusion complexes, and the interaction of 2,6-DMCD with both the chromanol head and the phytol chain of Toc was revealed by 2D ROESY nuclear magnetic resonance analysis.	Cyclodextrins	67-69	rhomboid 5 homolog 2	Homo sapiens	63-66
34497177-9	2021	Additionally, a rapid scavenging effect for molecularly dissolved Toc was demonstrated even in a system comprising a chromanol head directly encapsulated by CD.	Cyclodextrins	157-159	rhomboid 5 homolog 2	Homo sapiens	66-69
34683887-0	2021	Proving Nanoscale Chiral Interactions of Cyclodextrins and Propranolol Enantiomers by Means of SERS Measurements Performed on a Solid Plasmonic Substrate.	Cyclodextrins	41-54	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	95-99
34128161-5	2021	Moreover, the addition of cyclodextrins (HP-beta-CD and beta-CD) in aqueous media enhanced the fluorescence of pindolol.	Cyclodextrins	26-39	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	44-51
34128161-5	2021	Moreover, the addition of cyclodextrins (HP-beta-CD and beta-CD) in aqueous media enhanced the fluorescence of pindolol.	Cyclodextrins	26-39	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	56-63
34254791-5	2021	The supramolecular hydrogels were prepared to encapsulate fibroblasts by the host-guest interaction of cyclodextrin-modified gelatin (GE-CD) and adamantane-modified hyaluronate (Ad-HA) in conjugation with human growth hormone (hGH) for accelerated skin tissue regeneration.	Cyclodextrins	103-115	growth hormone 1	Homo sapiens	211-225
34254791-5	2021	The supramolecular hydrogels were prepared to encapsulate fibroblasts by the host-guest interaction of cyclodextrin-modified gelatin (GE-CD) and adamantane-modified hyaluronate (Ad-HA) in conjugation with human growth hormone (hGH) for accelerated skin tissue regeneration.	Cyclodextrins	103-115	gamma-glutamyl hydrolase	Homo sapiens	227-230
34409609-2	2021	Isolating products from cyclodextrin (CD) complexation, using beta-CD and its derivatives, is usually a time and energy-consuming process.	Cyclodextrins	24-36	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	62-69
34271152-5	2021	In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-kappaB) in the treatment of CRC.	Cyclodextrins	39-51	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	214-218
34271152-5	2021	In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-kappaB) in the treatment of CRC.	Cyclodextrins	39-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	233-242
34271152-5	2021	In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-kappaB) in the treatment of CRC.	Cyclodextrins	53-55	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	214-218
34271152-5	2021	In this study, an amphiphilic cationic cyclodextrin (CD) nanoparticle modified with PEGylated folate (FA; a ligand to target folate receptor on CRC) has been developed for co-delivery of DTX and siRNA (against the RelA, a subunit of NF-kappaB) in the treatment of CRC.	Cyclodextrins	53-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	233-242
34271152-7	2021	The CD.DTX.siRelA.PEG-FA nanoparticle enhanced the apoptotic effect of DTX with the downregulation of RelA expression, which significantly retarded the growth of CRC in mice, without causing significant toxicity.	Cyclodextrins	4-6	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	102-106
34409609-2	2021	Isolating products from cyclodextrin (CD) complexation, using beta-CD and its derivatives, is usually a time and energy-consuming process.	Cyclodextrins	38-40	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	62-69
35430479-8	2022	In case of 2-(4-bromobenzylsulfinyl)-N-methyl benzamide in the presence of heptakis(2,3-di-O-methyl-6-O-sulfo)-alpha-CD reversal of the enantiomer migration order as a function of the CD concentration was observed.	Cyclodextrins	184-186	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	111-119
34414164-2	2021	Using cyclodextrin glucanotransferase to catalyze reversible transglycosylation, dynamic mixtures of interconverting cyclodextrins can be formed wherein the relative concentrations of alpha-CD, beta-CD and gamma-CD is determined by their intrinsic stabilities and any stabilizing influences of added template (guest) molecules.	Cyclodextrins	6-18	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	194-201
34414164-2	2021	Using cyclodextrin glucanotransferase to catalyze reversible transglycosylation, dynamic mixtures of interconverting cyclodextrins can be formed wherein the relative concentrations of alpha-CD, beta-CD and gamma-CD is determined by their intrinsic stabilities and any stabilizing influences of added template (guest) molecules.	Cyclodextrins	117-130	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	184-192
34414164-2	2021	Using cyclodextrin glucanotransferase to catalyze reversible transglycosylation, dynamic mixtures of interconverting cyclodextrins can be formed wherein the relative concentrations of alpha-CD, beta-CD and gamma-CD is determined by their intrinsic stabilities and any stabilizing influences of added template (guest) molecules.	Cyclodextrins	117-130	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	194-201
34414164-3	2021	Here, we find that addition of high concentrations of kosmotropic anions can be used to enhance the effects of added hydrophobic templates, while chaotropic anions can themselves act as templates, causing predictable and significant changes in the cyclodextrin composition due to weak, but specific, binding interactions with alpha-CD.	Cyclodextrins	248-260	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	326-334
34361559-1	2021	The aim of this research is to obtain new data about the complexation between beta-cyclodextrin (beta-CD) and benzoic acid (BA) as a model reaction of the complex formation of hydrophobic molecules with cyclodextrins (CDs) in various media.	Cyclodextrins	203-216	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	97-104
34361559-1	2021	The aim of this research is to obtain new data about the complexation between beta-cyclodextrin (beta-CD) and benzoic acid (BA) as a model reaction of the complex formation of hydrophobic molecules with cyclodextrins (CDs) in various media.	Cyclodextrins	218-221	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	97-104
34356363-5	2021	A total of 42 compounds were identified, including stilbenes, flavonoids, and phenolic acids, and a complex of (epi)catechin with beta-CD was detected, confirming the interaction between polyphenols and cyclodextrin.	Cyclodextrins	203-215	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	130-137
34109172-0	2021	Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss.	Cyclodextrins	98-110	solute carrier family 26 member 5	Homo sapiens	45-52
34069454-5	2021	We envision that localized therapeutic inhibition of Cav1 in management of FFA (by cholesterol depleting agents, i.e., cyclodextrins/statins), could inhibit and potentially reverse bulge IP collapse and pathological EMT.	Cyclodextrins	119-132	caveolin 1, caveolae protein	Mus musculus	53-57
34360752-5	2021	By envisaging a biosafe cytocompatible and haemocompatible profile, this paper reports the systematic development of a delivery system based on CS and derived with HA and CDs to nanoencapsulate the model human phenylalanine hydroxylase (hPAH) through ionotropic gelation with tripolyphosphate (TPP), while maintaining protein stability and enzyme activity.	Cyclodextrins	171-174	phenylalanine hydroxylase	Homo sapiens	210-235
34360752-5	2021	By envisaging a biosafe cytocompatible and haemocompatible profile, this paper reports the systematic development of a delivery system based on CS and derived with HA and CDs to nanoencapsulate the model human phenylalanine hydroxylase (hPAH) through ionotropic gelation with tripolyphosphate (TPP), while maintaining protein stability and enzyme activity.	Cyclodextrins	171-174	phenylalanine hydroxylase	Homo sapiens	237-241
34355087-3	2021	From the investigated nine cyclodextrins - differing in cavity size, nature of substituents, degree of substitution and charge - the highest solubility increase was observed with sulfobutylether-beta-cyclodextrin (SBE-beta-CD).	Cyclodextrins	27-40	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	218-225
34180226-2	2021	In the present study, the effect of CD on the amorphous drug solubility and the maximum thermodynamic activity of the drug in the aqueous phase when the drug concentration exceeded the liquid-liquid phase separation (LLPS) concentration was investigated using three chemically diverse CDs, beta-cyclodextrin (beta-CD), dimethyl-beta-CD (DM-beta-CD), and hydroxypropyl-beta-CD (HP-beta-CD).	Cyclodextrins	36-38	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	380-387
34184163-7	2021	Lopinavir (LPV) and ritonavir (RTV), available as FDA-approved fixed-dose combination products, were chosen as model ART drugs, and the formulation and processing parameters of spray-dried cyclodextrin (CD)-based LPV and RTV complexes were studied.	Cyclodextrins	203-205	cyclodextrin	None	189-201
35456540-5	2022	The enhanced solubility of CBD upon complexation with CDs was examined by phase solubility study, and the structure of the inclusion complexes of CBD in 2,6-di-O-methyl-beta-CD (DM-beta-CD) and 2,3,6-tri-O-methyl-beta-CD (TM-beta-CD) was determined by X-ray crystallography.	Cyclodextrins	54-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	181-188
35074707-0	2022	KLVFF oligopeptide-decorated amphiphilic cyclodextrin nanomagnets for selective amyloid beta recognition and fishing.	Cyclodextrins	41-53	amyloid beta precursor protein	Homo sapiens	80-92
35424977-1	2022	Among the cyclodextrins screened for the synthesis of 2-hydroxy-1,2-diphenylethanone (benzoin) in water, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) exhibited the highest yield in the benzoin condensation reactions, and HP-beta-CD can be recycled several times with little loss of activity through the addition of fresh VB1.	Cyclodextrins	10-23	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	143-150
35383788-3	2022	Templates can be employed to favour the selective production of specific CDs and, herein, we show that by using ionisable templates, the synthesis of alpha-CD or beta-CD can be favoured by simply changing the pH.	Cyclodextrins	73-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	150-158
35383788-3	2022	Templates can be employed to favour the selective production of specific CDs and, herein, we show that by using ionisable templates, the synthesis of alpha-CD or beta-CD can be favoured by simply changing the pH.	Cyclodextrins	73-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	162-169
35454706-0	2022	Beneficial Effects of Three Dietary Cyclodextrins on Preventing Fat Accumulation and Remodeling Gut Microbiota in Mice Fed a High-Fat Diet.	Cyclodextrins	36-49	CD36 molecule	Mus musculus	64-67
35456540-5	2022	The enhanced solubility of CBD upon complexation with CDs was examined by phase solubility study, and the structure of the inclusion complexes of CBD in 2,6-di-O-methyl-beta-CD (DM-beta-CD) and 2,3,6-tri-O-methyl-beta-CD (TM-beta-CD) was determined by X-ray crystallography.	Cyclodextrins	54-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	213-220
35456540-5	2022	The enhanced solubility of CBD upon complexation with CDs was examined by phase solubility study, and the structure of the inclusion complexes of CBD in 2,6-di-O-methyl-beta-CD (DM-beta-CD) and 2,3,6-tri-O-methyl-beta-CD (TM-beta-CD) was determined by X-ray crystallography.	Cyclodextrins	54-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	225-232
35240960-1	2022	AIMS: Herein, molecular docking approaches and DFT ab initio simulations were combined for the first time, to study the key interactions of cyclodextrins (CDs: alpha-CD, beta-CD, and gamma-CD) family with potential pharmacological relevance and the multidrug resistance P-gp protein toward efficient drug-delivery applications.	Cyclodextrins	140-153	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	160-168
35240960-1	2022	AIMS: Herein, molecular docking approaches and DFT ab initio simulations were combined for the first time, to study the key interactions of cyclodextrins (CDs: alpha-CD, beta-CD, and gamma-CD) family with potential pharmacological relevance and the multidrug resistance P-gp protein toward efficient drug-delivery applications.	Cyclodextrins	140-153	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	170-177
35240960-1	2022	AIMS: Herein, molecular docking approaches and DFT ab initio simulations were combined for the first time, to study the key interactions of cyclodextrins (CDs: alpha-CD, beta-CD, and gamma-CD) family with potential pharmacological relevance and the multidrug resistance P-gp protein toward efficient drug-delivery applications.	Cyclodextrins	140-153	phosphoglycolate phosphatase	Homo sapiens	270-274
35240960-8	2022	Despite the structural differences, all the cyclodextrins exhibit very close Gibbs free binding energy values (or affinity) by the P-gp binding site (transmembrane domains - TMDs).	Cyclodextrins	44-57	phosphoglycolate phosphatase	Homo sapiens	131-135
35164347-0	2022	Cyclodextrins Initiated Ring-Opening Polymerization of Lactide Using 4-Dimethylaminopyridine (DMAP) as Catalyst: Study of DMAP/beta-CD Inclusion Complex and Access to New Structures.	Cyclodextrins	0-13	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	127-134
35164347-9	2022	Polymerization results including also the use of the adamantane/beta-CD inclusion complex as an initiator suggest that inclusion of the DMAP catalyst into the CD may not occur during polymerization reactions.	Cyclodextrins	159-161	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	64-71
35056780-0	2022	Insulin Complexation with Cyclodextrins-A Molecular Modeling Approach.	Cyclodextrins	26-39	insulin	Homo sapiens	0-7
3106037-5	1987	alpha-Amylase was active on cyclodextrins, whereas debranching activity was demonstrated for glucoamylase.	Cyclodextrins	28-41	PAN0_001d0774	Moesziomyces antarcticus	0-13
35397161-7	2022	These findings suggest that the cyclodextrins, unlike their linear analogs, are ligands of the human sweet taste receptor, hT1R2/hT1R3.	Cyclodextrins	32-45	taste 1 receptor member 2	Homo sapiens	123-128
35397161-7	2022	These findings suggest that the cyclodextrins, unlike their linear analogs, are ligands of the human sweet taste receptor, hT1R2/hT1R3.	Cyclodextrins	32-45	taste 1 receptor member 3	Homo sapiens	129-134
35053211-3	2022	Recently, we have investigated the modulation of genes involved in cancer-associated canonical pathways induced by graphene engineered with cyclodextrins (GCD).	Cyclodextrins	140-153	guanylate cyclase 2E, pseudogene	Homo sapiens	155-158
3803759-2	1986	The interaction of soman, a mixture of four stereoisomers designated as C(+)P(-), C(-)P(-), C(+)P(+), and C(-)P(+), with cyclodextrins was revealed by methods based on the irreversible inhibition of acetylcholinesterase (AChE) that is phosphonylated chiefly by P(-)-isomers of racemic soman and continuous titration of fluoride ions released by soman using a fluoride-specific electrode.	Cyclodextrins	121-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	199-219
3816937-5	1987	The order of effectiveness of various cyclodextrin compounds tested was as follows: beta-CD (100) greater than alpha-CD(30) greater than gamma-CD(10) greater than heptakis (2,6-O-dimethyl)beta-CD (less than 1).	Cyclodextrins	38-50	beta-carotene oxygenase 1	Mus musculus	84-91
3816937-5	1987	The order of effectiveness of various cyclodextrin compounds tested was as follows: beta-CD (100) greater than alpha-CD(30) greater than gamma-CD(10) greater than heptakis (2,6-O-dimethyl)beta-CD (less than 1).	Cyclodextrins	38-50	beta-carotene oxygenase 1	Mus musculus	188-195
3803759-2	1986	The interaction of soman, a mixture of four stereoisomers designated as C(+)P(-), C(-)P(-), C(+)P(+), and C(-)P(+), with cyclodextrins was revealed by methods based on the irreversible inhibition of acetylcholinesterase (AChE) that is phosphonylated chiefly by P(-)-isomers of racemic soman and continuous titration of fluoride ions released by soman using a fluoride-specific electrode.	Cyclodextrins	121-134	acetylcholinesterase (Cartwright blood group)	Homo sapiens	221-225
34028978-3	2021	RNase A bioreversibly modified with adamantane is functionalized with wind chime-like lysine modified cyclodextrin (WLC) to generate RNase A-WLC (R-WLC).	Cyclodextrins	102-114	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
3791296-2	1986	The reaction rate was greater with maltotriose than with maltose, and with increasing size of the cyclomalto-oligosaccharide (cG6 less than cG7 less than cG8).	Cyclodextrins	98-124	ferric chelate reductase 1 like	Homo sapiens	126-129
3791296-2	1986	The reaction rate was greater with maltotriose than with maltose, and with increasing size of the cyclomalto-oligosaccharide (cG6 less than cG7 less than cG8).	Cyclodextrins	98-124	actin binding transcription modulator	Homo sapiens	154-157
33999634-5	2021	Bulk simulations revealed that CDs were preferentially included within the surface hydration layer of GCSF, and even included some peptide residues in their hydrophobic cavity.	Cyclodextrins	31-34	colony stimulating factor 3	Homo sapiens	102-106
33759328-4	2021	A manipulation of the monomer-aggregate equilibrium of the dye-polyelectrolyte assembly has been achieved by introducing a cyclodextrin based supramolecule host, SBE-beta-CD, which leads to relocation of AuO molecules from polyelectrolyte (PSS) to supramolecular host cavity, owing to the formation of a host-guest complex between AuO and SBE-beta-CD.	Cyclodextrins	123-135	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	166-173
33759328-4	2021	A manipulation of the monomer-aggregate equilibrium of the dye-polyelectrolyte assembly has been achieved by introducing a cyclodextrin based supramolecule host, SBE-beta-CD, which leads to relocation of AuO molecules from polyelectrolyte (PSS) to supramolecular host cavity, owing to the formation of a host-guest complex between AuO and SBE-beta-CD.	Cyclodextrins	123-135	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	343-350
33998953-4	2021	In this study using molecular dynamics (MD) simulation, five commonly used biodegradable biopolymers in pharmaceutical formulations including Chitosan, Alginate, Cyclodextrin, Hyaluronic Acid, and Pectin were investigated as proper carriers for the erythropoietin (EPO) in heat stress.	Cyclodextrins	162-174	erythropoietin	Homo sapiens	249-263
33991594-0	2021	Age-related ocular conditions: Current treatments and role of cyclodextrin-based nanotherapies.	Cyclodextrins	62-74	renin binding protein	Homo sapiens	0-3
33991594-10	2021	In this review, we discuss emerging therapeutic options based on nanoengineering of cyclodextrin nanocarriers for the treatment of age-related eye disorders, including their pathophysiology, pharmacological options, and feasibility of clinical translation.	Cyclodextrins	84-96	renin binding protein	Homo sapiens	131-134
33946414-3	2021	A sulfobutyl ether derivative of beta-cyclodextrin (SBE-beta-CD) was selected based on phase solubility studies and molecular modeling to prepare an inclusion complex of BDQ and cyclodextrin.	Cyclodextrins	38-50	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	56-63
33183870-0	2021	Potential ability of different types of cyclodextrins to modulate the interaction between bovine serum albumin and 1-hydroxypyrene.	Cyclodextrins	40-53	albumin	Homo sapiens	97-110
33183870-2	2021	Four types of cyclodextrins (CDs) were selected to explore their potential ability to regulate the bindings between 1-hydroxypyrene (1-OHPyr) and bovine serum albumin (BSA) using multi-spectroscopic methods combined with molecular docking.	Cyclodextrins	14-27	albumin	Homo sapiens	153-166
33183870-2	2021	Four types of cyclodextrins (CDs) were selected to explore their potential ability to regulate the bindings between 1-hydroxypyrene (1-OHPyr) and bovine serum albumin (BSA) using multi-spectroscopic methods combined with molecular docking.	Cyclodextrins	29-32	albumin	Homo sapiens	153-166
33183870-3	2021	The results showed that the four CDs caused varied modulating effects on the binding of BSA with 1-OHPyr, and the effects of gamma-CD and (2-hydroxypropyl)-beta-CD (HPCD) are the most significant.	Cyclodextrins	33-36	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	156-163
33899562-2	2021	Dexamethasone (DEX) was employed as a hydrophobic model drug, which incorporated into the network of hydroxyapatite (HA)/Cyclodextrin (beta-CD) nanocomposite.	Cyclodextrins	121-133	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	135-142
33548310-1	2021	Human serum albumin (HSA) plays a pivotal role in drug release from its delivery vehicles such as cyclodextrins (CDs) by binding to the drugs.	Cyclodextrins	98-111	albumin	Homo sapiens	6-19
33919170-1	2021	Understanding the host-guest chemistry of alpha-/beta-/gamma- cyclodextrins (CDs) and a wide range of organic species are fundamentally attractive, and are finding broad contemporary applications toward developing efficient drug delivery systems.	Cyclodextrins	77-80	amyloid beta precursor protein	Homo sapiens	42-53
33919170-1	2021	Understanding the host-guest chemistry of alpha-/beta-/gamma- cyclodextrins (CDs) and a wide range of organic species are fundamentally attractive, and are finding broad contemporary applications toward developing efficient drug delivery systems.	Cyclodextrins	77-80	amyloid beta precursor protein	Homo sapiens	7-8
33548310-1	2021	Human serum albumin (HSA) plays a pivotal role in drug release from its delivery vehicles such as cyclodextrins (CDs) by binding to the drugs.	Cyclodextrins	113-116	albumin	Homo sapiens	6-19
33548310-2	2021	Here molecular recognition and binding of a drug mimic (CD1) to HSA have been explored in a microfluidic channel when CD1 is encapsulated in beta-cyclodextrin (CD) and heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (TRIMEB), respectively, to investigate whether change of the host vehicle modulate the rate of drug binding to the serum protein.	Cyclodextrins	56-58	CD1c molecule	Homo sapiens	118-121
33924348-3	2021	We designed a cyclodextrin (CD)-based polymeric complex to deliver chemotherapeutic doxorubicin (DOX) and Nur77DeltaDBD gene for combating pumps and non-pump resistance simultaneously.	Cyclodextrins	14-26	nuclear receptor subfamily 4 group A member 1	Homo sapiens	106-119
33919692-2	2021	There are situations when the use of a single CD as CS is not enough to obtain efficient chiral discrimination of the enantiomers; in these cases, sometimes this problem can be resolved using a dual CD system.	Cyclodextrins	46-48	citrate synthase	Homo sapiens	52-54
33919692-2	2021	There are situations when the use of a single CD as CS is not enough to obtain efficient chiral discrimination of the enantiomers; in these cases, sometimes this problem can be resolved using a dual CD system.	Cyclodextrins	199-201	citrate synthase	Homo sapiens	52-54
33919692-3	2021	The use of dual CD systems can often dramatically enhance enantioseparation selectivity and can be applied for the separation of many analytes of pharmaceutical interest for which enantioseparation by CE with another CS systems can be problematic.	Cyclodextrins	16-18	citrate synthase	Homo sapiens	217-219
33924348-3	2021	We designed a cyclodextrin (CD)-based polymeric complex to deliver chemotherapeutic doxorubicin (DOX) and Nur77DeltaDBD gene for combating pumps and non-pump resistance simultaneously.	Cyclodextrins	28-30	nuclear receptor subfamily 4 group A member 1	Homo sapiens	106-119
33898875-4	2021	In this nanosystem, miR-122 is condensed by the outer cationic poly (2-(dimethylamino) ethyl methacrylate) chains of sCDP while DOX is accommodated in the inner hydrophobic cyclodextrin cavities, endowing a sequential release manner of miR-122 and DOX.	Cyclodextrins	173-185	microRNA 122	Homo sapiens	20-27
33898875-0	2021	Preferentially released miR-122 from cyclodextrin-based star copolymer nanoparticle enhances hepatoma chemotherapy by apoptosis induction and cytotoxics efflux inhibition.	Cyclodextrins	37-49	microRNA 122	Homo sapiens	24-31
33558562-6	2021	Molecular docking with the two best CDs gave better scores for alpha-CD, despite HP-beta-CD providing stabilization through H-bonds.	Cyclodextrins	36-39	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	63-71
33898875-3	2021	Herein, a cyclodextrin-cored star copolymer nanoparticle system (sCDP/DOX/miR-122) is constructed to co-deliver miR-122 with doxorubicin (DOX) for hepatoma therapy.	Cyclodextrins	10-22	microRNA 122	Homo sapiens	74-81
33898875-3	2021	Herein, a cyclodextrin-cored star copolymer nanoparticle system (sCDP/DOX/miR-122) is constructed to co-deliver miR-122 with doxorubicin (DOX) for hepatoma therapy.	Cyclodextrins	10-22	microRNA 122	Homo sapiens	112-119
33644914-3	2021	First an anionic cyclodextrin, the SBE-beta-CD, was selected to allow the chiral separation of our neutral compound and partial resolutions of the eight isomers were obtained.	Cyclodextrins	17-29	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	39-46
33650825-2	2021	Here, we have investigated whether cyclodextrin (CD) and apolipoprotein A-I (apoA-I) induce the same signal to inhibit cell cholesterol accumulation by focusing on the main proteins involved in cholesterol homeostasis in response to CD and apoA-I treatment.	Cyclodextrins	35-47	apolipoprotein A-I	Mus musculus	240-246
33650825-2	2021	Here, we have investigated whether cyclodextrin (CD) and apolipoprotein A-I (apoA-I) induce the same signal to inhibit cell cholesterol accumulation by focusing on the main proteins involved in cholesterol homeostasis in response to CD and apoA-I treatment.	Cyclodextrins	233-235	apolipoprotein A-I	Mus musculus	77-83
33650825-6	2021	Results: ApoA-I induced a significant increase in ABCA1 and a mild increase in HMGCR protein level, whereas CD caused a significant increase in HMGCR with a significant decrease in ABCA1.	Cyclodextrins	108-110	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	Mus musculus	144-149
33650825-6	2021	Results: ApoA-I induced a significant increase in ABCA1 and a mild increase in HMGCR protein level, whereas CD caused a significant increase in HMGCR with a significant decrease in ABCA1.	Cyclodextrins	108-110	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	181-186
33650825-9	2021	Conclusion: CD, like apoA-I, depletes cellular cholesterol.	Cyclodextrins	12-14	apolipoprotein A-I	Mus musculus	21-27
33556487-4	2021	The study was designed to formulate docetaxel-cyclodextrins inclusion complexes for enhancement of solubility with sulfobutyl ether beta-cyclodextrin (SBE7-beta-CD), hydroxypropyl beta-cyclodextrin (HP-beta-CD) and beta-cyclodextrin (beta-CD).	Cyclodextrins	46-59	LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog	Oryctolagus cuniculus	156-163
33556487-4	2021	The study was designed to formulate docetaxel-cyclodextrins inclusion complexes for enhancement of solubility with sulfobutyl ether beta-cyclodextrin (SBE7-beta-CD), hydroxypropyl beta-cyclodextrin (HP-beta-CD) and beta-cyclodextrin (beta-CD).	Cyclodextrins	46-59	LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog	Oryctolagus cuniculus	202-209
33556487-4	2021	The study was designed to formulate docetaxel-cyclodextrins inclusion complexes for enhancement of solubility with sulfobutyl ether beta-cyclodextrin (SBE7-beta-CD), hydroxypropyl beta-cyclodextrin (HP-beta-CD) and beta-cyclodextrin (beta-CD).	Cyclodextrins	46-59	LOW QUALITY PROTEIN: adrenocortical dysplasia protein homolog	Oryctolagus cuniculus	202-209
33554997-3	2021	Using cyclodextrin glucanotransferase to catalyse reversible transglycosylation, and 1-adamantane carboxylic acid as the template, we can synthesise beta-CD from maltose in approximately 70% yield.	Cyclodextrins	6-18	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	149-156
33541570-4	2021	The in vitro profiles of CUR release from beta-CD showed that 100 % of the drug was released after one hour incubation in the presence of MAase with cyclodextrin degrading activity.	Cyclodextrins	149-161	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	42-49
33152374-4	2021	This study describes the pre-clinical development of a cyclodextrin-based NP formulation containing the GLP-1 analogue liraglutide for intestinal administration.	Cyclodextrins	55-67	glucagon like peptide 1 receptor	Homo sapiens	104-109
33553939-1	2021	A new Janus-type cyclodextrin (CD) molecular tube bearing seven triisopropylsilyl (TIPS) groups at one end is synthesized from a heptakis(6-O-triisopropylsilyl)-beta-cyclodextrin (TIPS-beta-CD) dimer possessing multiple linkers through the selective removal of seven TIPS groups at the other end.	Cyclodextrins	31-33	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	185-192
33325586-4	2021	Here, a coassembly composed of cyclodextrin (CD) and calixarene (CA) is designed, and it is used as an anti-Abeta therapy agent.	Cyclodextrins	31-43	amyloid beta (A4) precursor protein	Mus musculus	108-113
33325586-4	2021	Here, a coassembly composed of cyclodextrin (CD) and calixarene (CA) is designed, and it is used as an anti-Abeta therapy agent.	Cyclodextrins	45-47	amyloid beta (A4) precursor protein	Mus musculus	108-113
33035885-3	2021	The beta-CD-QDs exhibited different quenching effect to the S-(+)-ibuprofen and the R-(-)-ibuprofen based on the advantage of the inclusion complex of cyclodextrin.	Cyclodextrins	151-163	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	4-11
32987113-5	2021	Among tested cyclodextrins, the best results were obtained with 2-HP-beta-CD, which promoted an 18-fold increase in RN104"s aqueous solubility.	Cyclodextrins	13-26	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	69-76
33299648-6	2020	Results: Although both PVP-HM and cyclodextrin-HM formulations showed promising P-gp inhibition activity in vitro, cyclodextrin-HM had a higher maximum tolerated dose in mice than did PVP-HM.	Cyclodextrins	34-46	phosphoglycolate phosphatase	Mus musculus	80-84
33201379-7	2020	Using alpha-cyclodextrin as a donor substrate, cyclodextrin glucanotransferase elongated both the main and side branches on B3/31, while all the glycosidic bonds in B3/31 were left intact.	Cyclodextrins	12-24	immunoglobulin kappa variable 4-1	Homo sapiens	124-129
33201379-7	2020	Using alpha-cyclodextrin as a donor substrate, cyclodextrin glucanotransferase elongated both the main and side branches on B3/31, while all the glycosidic bonds in B3/31 were left intact.	Cyclodextrins	12-24	immunoglobulin kappa variable 4-1	Homo sapiens	165-170
33084317-3	2020	Fully regular star polymers built on biocompatible macrocyclic platforms, such as hyperbranched cyclodextrins, offer advantages in terms of facile synthesis and flexible compositions, but core elaboration in terms of shape and function becomes problematic.	Cyclodextrins	96-109	steroidogenic acute regulatory protein	Homo sapiens	14-18
33287127-8	2020	The RSP solubility was enhanced as a result of drug encapsulation in the CDs cavity, the higher increase being obtained with DM-beta-CD as host; the guest-host system RSP/DM-beta-CD can thus be a starting point for further research in developing new formulations containing RSP, with enhanced bioavailability.	Cyclodextrins	73-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	128-135
33287127-8	2020	The RSP solubility was enhanced as a result of drug encapsulation in the CDs cavity, the higher increase being obtained with DM-beta-CD as host; the guest-host system RSP/DM-beta-CD can thus be a starting point for further research in developing new formulations containing RSP, with enhanced bioavailability.	Cyclodextrins	73-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	174-181
32090640-3	2020	Meanwhile, 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD), a widely used cyclodextrin analog, is a safe and an effective drug carrier.	Cyclodextrins	32-44	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	49-56
32864834-1	2020	In this study, a novel cyclodextrin derivative, i.e., zwitterionic choline phosphate (CP)-functionalized beta-cyclodextrin (CP-beta-CD) is successfully synthesized by click chemistry reaction.	Cyclodextrins	23-35	carboxypeptidase A1	Homo sapiens	124-131
33025286-3	2020	The process involved ternary (hydrophobic/ionic/supramolecular) interactions in three steps: 1) CFZ was entrapped in the cavity of HabetaCD by hydrophobic interaction, 2) the drug-cyclodextrin inclusion complexes were mixed with N3-PEG-PLE to form polyion complex nanoparticles, and 3) the nanoparticles were modified with fluorescent dyes (AFDye 647) for imaging and/or epithelial cell adhesion molecule (EpCAM) antibodies for cancer cell targeting.	Cyclodextrins	180-192	epithelial cell adhesion molecule	Homo sapiens	371-404
32916214-1	2020	In this work, the increase of the Caenorhabditis elegans (C.elegans) lifespan extension using hyper-branched cyclodextrin-based nanosponges (CD-NS) complexing oxyresveratrol (OXY), and the possible inhibition of C.elegans phosphodiesterase type 4 (PDE4) were evaluated.	Cyclodextrins	109-121	Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-4	Caenorhabditis elegans	222-246
32916214-1	2020	In this work, the increase of the Caenorhabditis elegans (C.elegans) lifespan extension using hyper-branched cyclodextrin-based nanosponges (CD-NS) complexing oxyresveratrol (OXY), and the possible inhibition of C.elegans phosphodiesterase type 4 (PDE4) were evaluated.	Cyclodextrins	109-121	Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-4	Caenorhabditis elegans	248-252
32887111-3	2020	In this contribution, LON analysis methods were developed in cyclodextrin-modified capillary zone electrophoresis (CD-CZE).	Cyclodextrins	61-73	lon peptidase 1, mitochondrial	Homo sapiens	22-25
33060727-0	2020	Cyclodextrin inclusion complex inhibits circulating galectin-3 and FGF-7 and affects the reproductive integrity and mobility of Caco-2 cells.	Cyclodextrins	0-12	galectin 3	Homo sapiens	52-62
33060727-0	2020	Cyclodextrin inclusion complex inhibits circulating galectin-3 and FGF-7 and affects the reproductive integrity and mobility of Caco-2 cells.	Cyclodextrins	0-12	fibroblast growth factor 7	Homo sapiens	67-72
32914795-1	2020	A supramolecular complex of syn-(methyl,methyl)bimane (1) and beta-cyclodextrin demonstrates a sensitive (limit of detection = 0.60 nM) and selective fluorescence turn-off response in the presence of cobalt in aqueous media, with calibration curves enabling quantitation in solution and using filter papers on which bimane and cyclodextrin were adsorbed.	Cyclodextrins	67-79	synemin	Homo sapiens	28-31
32916214-3	2020	Moreover, PDE4 was expressed in E.coli, purified and refolded in presence of cyclodextrins (CDs) to study its possible inhibition as pharmacological target of OXY.	Cyclodextrins	77-90	Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-4	Caenorhabditis elegans	10-14
32916214-3	2020	Moreover, PDE4 was expressed in E.coli, purified and refolded in presence of cyclodextrins (CDs) to study its possible inhibition as pharmacological target of OXY.	Cyclodextrins	92-95	Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-4	Caenorhabditis elegans	10-14
33171970-3	2020	The aim of this study was to investigate the biocompatibility of CHR complexes with two cyclodextrins (CDs)-(2-hydroxypropyl)-beta-cyclodextrin (HPBCD) and random methyl-beta-cyclodextrin (RAMEB), and their potential to induce anti-inflammatory, antioxidant and anti-fibrotic effects.	Cyclodextrins	88-101	chromate resistance; sulfate transport	Homo sapiens	65-68
33171970-3	2020	The aim of this study was to investigate the biocompatibility of CHR complexes with two cyclodextrins (CDs)-(2-hydroxypropyl)-beta-cyclodextrin (HPBCD) and random methyl-beta-cyclodextrin (RAMEB), and their potential to induce anti-inflammatory, antioxidant and anti-fibrotic effects.	Cyclodextrins	103-106	chromate resistance; sulfate transport	Homo sapiens	65-68
33025286-3	2020	The process involved ternary (hydrophobic/ionic/supramolecular) interactions in three steps: 1) CFZ was entrapped in the cavity of HabetaCD by hydrophobic interaction, 2) the drug-cyclodextrin inclusion complexes were mixed with N3-PEG-PLE to form polyion complex nanoparticles, and 3) the nanoparticles were modified with fluorescent dyes (AFDye 647) for imaging and/or epithelial cell adhesion molecule (EpCAM) antibodies for cancer cell targeting.	Cyclodextrins	180-192	epithelial cell adhesion molecule	Homo sapiens	406-411
32390137-0	2020	Cyclodextrin-micellar electrokinetic chromatography of apolipoproteins on human very low-density lipoprotein.	Cyclodextrins	0-12	apolipoprotein E	Homo sapiens	55-70
32634570-5	2020	In the present work, we demonstrate that epichlorohydrin-crosslinked CD nanosponges based on beta-CD (betaCDp) and carboxymethyl-beta-CD (CMbetaCDp) monomers efficiently encapsulated mTHPC.	Cyclodextrins	69-71	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	93-100
32634570-5	2020	In the present work, we demonstrate that epichlorohydrin-crosslinked CD nanosponges based on beta-CD (betaCDp) and carboxymethyl-beta-CD (CMbetaCDp) monomers efficiently encapsulated mTHPC.	Cyclodextrins	69-71	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	129-136
32876723-0	2020	Photoluminescent hydrophilic cyclodextrin-stabilized cysteine-protected copper nanoclusters for detecting lysozyme.	Cyclodextrins	29-41	lysozyme	Homo sapiens	106-114
32479931-1	2020	A targeted and controlled drug delivery system based on beta-cyclodextrin (beta-CD) for encapsulation and controlled release of hydrophobic drugs in the presence of maltogenic amylase (MAase), as a cyclodextrin-hydrolyzing enzyme, and trastuzumab antibody has been developed.	Cyclodextrins	61-73	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	75-82
32354235-0	2020	Cyclodextrin Prevents Abdominal Aortic Aneurysm via Activation of Vascular Smooth Muscle Cell TFEB.	Cyclodextrins	0-12	transcription factor EB	Mus musculus	94-98
32478645-0	2020	Long-term stability of insulin glulisine loaded nanoparticles formulated using an amphiphilic cyclodextrin and designed for intestinal delivery.	Cyclodextrins	94-106	insulin	Homo sapiens	23-30
32584539-2	2020	Herein, a linear alternating supramolecular polymer is constructed via host-guest inclusion interaction between cyclodextrin-dimer (CD2) and bifunctional adamantane-conjugated porphyrin (TPP-Ad2).	Cyclodextrins	112-124	CD2 molecule	Homo sapiens	132-135
32584539-2	2020	Herein, a linear alternating supramolecular polymer is constructed via host-guest inclusion interaction between cyclodextrin-dimer (CD2) and bifunctional adamantane-conjugated porphyrin (TPP-Ad2).	Cyclodextrins	112-124	apolipoprotein E	Homo sapiens	191-194
32505293-2	2020	In most cases, determination of binding constant for analyte-cyclodextrin complexes in capillary electrophoresis is investigated by affinity capillary electrophoresis using a UV detector (ACE-UV).	Cyclodextrins	61-73	angiotensin I converting enzyme	Homo sapiens	188-191
32200243-3	2020	Electron spin resonance spectroscopy (ESR) and free radical quenching experiments indicate that various active species (SO4-/OH/O2-/1O2) are generated in the beta-CD-MnFe2O4/PMS system and that pollutants trapped in the cyclodextrin cavity are quickly degraded.	Cyclodextrins	220-232	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	158-165
32478645-3	2020	The aim of this work was to evaluate the stability of amphiphilic cyclodextrin-based nanoparticles (NPs) containing insulin glulisine.	Cyclodextrins	66-78	insulin	Homo sapiens	116-123
32213458-6	2020	Exploration of the effect of CDs (beta-CD and gamma-CD) on the niosome aids to have knowledge of the effect of CDs on cell membrane.	Cyclodextrins	29-32	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	34-41
32579062-3	2021	Using a combination of molecular modeling and simulation techniques, in this study the effects of five carbohydrate polymers of Chitosan, Alginate, Cyclodextrin, Hyaluronic acid and Pectin on structure and dynamics of interleukin2 protein at 298 K and 343 K, are investigated.	Cyclodextrins	148-160	interleukin 2	Homo sapiens	218-230
32579062-5	2021	Among different polymers, Chitosan and Cyclodextrin have shown to be able to protect protein against the negative effects of high temperatures in comparison with other polymers which suggests that the use of Cyclodextrin biopolymer for the preparation of pharmaceutical formulations of interleukin2 can be the best possible choice among other polymers investigated in this research.Communicated by Ramaswamy H. Sarma.	Cyclodextrins	39-51	interleukin 2	Homo sapiens	286-298
32579062-5	2021	Among different polymers, Chitosan and Cyclodextrin have shown to be able to protect protein against the negative effects of high temperatures in comparison with other polymers which suggests that the use of Cyclodextrin biopolymer for the preparation of pharmaceutical formulations of interleukin2 can be the best possible choice among other polymers investigated in this research.Communicated by Ramaswamy H. Sarma.	Cyclodextrins	208-220	interleukin 2	Homo sapiens	286-298
32325245-1	2020	We report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-beta-CD - MbetaCD and (2-hydroxy)propyl-beta-CD - HPbetaCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems.	Cyclodextrins	41-53	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	157-164
32325245-1	2020	We report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-beta-CD - MbetaCD and (2-hydroxy)propyl-beta-CD - HPbetaCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems.	Cyclodextrins	41-53	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	197-204
32325245-1	2020	We report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-beta-CD - MbetaCD and (2-hydroxy)propyl-beta-CD - HPbetaCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems.	Cyclodextrins	55-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	157-164
32325245-1	2020	We report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-beta-CD - MbetaCD and (2-hydroxy)propyl-beta-CD - HPbetaCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems.	Cyclodextrins	55-57	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	197-204
32325245-1	2020	We report the synthesis of water soluble cyclodextrin (CD) polymers prepared by crosslinking pyromellitic dianhydride (PMDA) with two CD derivatives (methyl-beta-CD - MbetaCD and (2-hydroxy)propyl-beta-CD - HPbetaCD) and their evaluation as functional sub-micron sized carriers in the development of antiretroviral drug delivery systems.	Cyclodextrins	134-136	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	157-164
32290618-4	2020	Here, we aimed to compare the effect of cyclodextrin (MbetaCD)- and nystatin-induced cholesterol modulations on stress-activated expression of the representative HSPs, HSP70, and HSP25 in mouse B16-F10 melanoma cells.	Cyclodextrins	40-52	heat shock protein 1B	Mus musculus	168-173
32503399-5	2021	Specifically, numerous vehicle platforms such as cyclodextrins and calixarenes have been widely utilized to host lipophilic drugs such as antagonists of the angiotensin II AT1 receptor (AT1R), as well as quercetin and silibinin.	Cyclodextrins	49-62	angiotensin II receptor type 1	Homo sapiens	186-190
32642006-7	2020	Deletion of Sirt6 also attenuated the protective effect of cyclodextrin (CD) on Ang II-induced urinary albumin excretion, glomerulosclerosis and podocyte injury.	Cyclodextrins	59-71	sirtuin 6	Mus musculus	12-17
32642006-7	2020	Deletion of Sirt6 also attenuated the protective effect of cyclodextrin (CD) on Ang II-induced urinary albumin excretion, glomerulosclerosis and podocyte injury.	Cyclodextrins	73-75	sirtuin 6	Mus musculus	12-17
32196938-4	2020	The SMART-EM data provided an estimation of the equilibrium constant of the CD binding to be close to that of adamantane ammonium chloride to beta-CD.	Cyclodextrins	76-78	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	142-149
32154964-0	2020	Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing the proton-coupled folate transporter.	Cyclodextrins	16-28	solute carrier family 46 member 1	Homo sapiens	81-114
32159339-6	2020	The hydrogel had a unique network structure involving two types of supramolecular self-assemblies between cyclodextrins and polymers, that is, the host-guest complexation between beta-CD units and adamantyl groups and the polypseudorotaxane formation between alpha-CD and PEG chains.	Cyclodextrins	106-119	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	179-186
32290618-4	2020	Here, we aimed to compare the effect of cyclodextrin (MbetaCD)- and nystatin-induced cholesterol modulations on stress-activated expression of the representative HSPs, HSP70, and HSP25 in mouse B16-F10 melanoma cells.	Cyclodextrins	40-52	heat shock protein 1	Mus musculus	179-184
31729219-1	2019	The theranostic ability of a new fluorescently labeled cationic cyclodextrin-graphene nanoplatform (GCD@Ada-Rhod) was investigated by studying its intracellular trafficking and its ability to deliver plasmid DNA and microRNA.	Cyclodextrins	64-76	guanylate cyclase 2E, pseudogene	Homo sapiens	100-103
32118400-4	2020	Owing to the multivalent binding between cyclodextrin and Ada, HACD, and peptide-grafted MNPs (MNP-ABP-Ada) could self-assemble to form MNP-ABP-Ada HACD nanofibers in a geomagnetism-dependent manner.	Cyclodextrins	41-53	sex hormone binding globulin	Homo sapiens	99-102
32218969-1	2020	A novel hydrophobic and cationic cyclodextrin-based acrylamide flocculant (AM-beta-CD-DMDAAC) was prepared by chemical oxidative polymerization to adsorb water-soluble dyes in dye wastewater.	Cyclodextrins	33-45	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-85
32187825-3	2020	Using smooth muscle cells (VSMCs) from mouse mesenteric arteries, we found that both Cav 3.2 channel inhibition by Ni2+ (50 microM) and caveolae disruption by methyl-ss-cyclodextrin or genetic abolition of Eps15 homology domain-containing protein (EHD2) inhibited Ca2+ sparks in cells from young (4 months) but not old (12 months) mice.	Cyclodextrins	169-181	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	85-92
31627834-4	2019	The Food and Drug Administration approved SGLT2 inhibitors, such as canagliflozin, empagliflozin, dapagliflozin, and ertugliflozin, for the treatment of type 2 diabetes.	Cyclodextrins	117-130	solute carrier family 5 member 2	Homo sapiens	42-47
31472864-3	2019	Characterizations of the prepared solid complexes using FTIR, XRD, TGA-DSC, and SEM indicate that GuN is found inside the cavity of the CDs.	Cyclodextrins	136-139	T-box transcription factor 1	Homo sapiens	67-70
31260986-2	2019	Cyclodextrins are cyclic glucan oligosaccharides that form inclusion complexes with a number of PPO substrates.	Cyclodextrins	0-13	catechol oxidase B, chloroplastic	Solanum tuberosum	96-99
31768494-2	2019	Although clinical data suggest that SGLT2is (empagliflozin, dapagliflozin, ertugliflozin, canagliflozin, ipragliflozin) are safe and protect against renal and cardiovascular events, very little attention has been dedicated to the effects of these compounds on different electrolytes.	Cyclodextrins	75-88	solute carrier family 5 member 2	Homo sapiens	36-41
31509117-6	2019	In order to efficiently control and treat HCC in the advanced stage, we developed a cyclodextrin (CD)-based chaperoned inclusion complex using Sorafenib (Sor), beta-CD and gamma-CD (SCD) via the co-crystallization method.	Cyclodextrins	84-96	adrenocortical dysplasia	Mus musculus	160-167
31509117-6	2019	In order to efficiently control and treat HCC in the advanced stage, we developed a cyclodextrin (CD)-based chaperoned inclusion complex using Sorafenib (Sor), beta-CD and gamma-CD (SCD) via the co-crystallization method.	Cyclodextrins	84-96	stearoyl-Coenzyme A desaturase 1	Mus musculus	172-186
31509117-6	2019	In order to efficiently control and treat HCC in the advanced stage, we developed a cyclodextrin (CD)-based chaperoned inclusion complex using Sorafenib (Sor), beta-CD and gamma-CD (SCD) via the co-crystallization method.	Cyclodextrins	98-100	adrenocortical dysplasia	Mus musculus	160-167
31509117-6	2019	In order to efficiently control and treat HCC in the advanced stage, we developed a cyclodextrin (CD)-based chaperoned inclusion complex using Sorafenib (Sor), beta-CD and gamma-CD (SCD) via the co-crystallization method.	Cyclodextrins	98-100	stearoyl-Coenzyme A desaturase 1	Mus musculus	172-186
31342792-5	2019	Results: The physicochemical studies showed that the RCa/CD complexes were well incorporated into CPNs resulted in nanosized particles (215.22 and 189.13 nm) with homogenous size distribution (PDI: 0.203 and 0.182) with relatively high incorporation capacity (76.11 and 68.18%) for the CPN1 and CPN2 formulations respectively.	Cyclodextrins	57-59	carboxypeptidase N subunit 1	Homo sapiens	286-290
31342792-5	2019	Results: The physicochemical studies showed that the RCa/CD complexes were well incorporated into CPNs resulted in nanosized particles (215.22 and 189.13 nm) with homogenous size distribution (PDI: 0.203 and 0.182) with relatively high incorporation capacity (76.11 and 68.18%) for the CPN1 and CPN2 formulations respectively.	Cyclodextrins	57-59	carboxypeptidase N subunit 2	Homo sapiens	295-299
31162826-4	2019	Cyclodextrins are cyclic glucose units that are extensively used in the pharmaceutical industry as formulating agents as well as for encapsulating hydrophobic molecules such as in the treatment of Niemann-Pick type C or for hypervitaminosis.	Cyclodextrins	0-13	protein interacting with PRKCA 1	Homo sapiens	205-209
31292985-2	2019	However, as potential toxicity limitations exist in the clinical use of Cremophor, an alternative cyclodextrin (SBE-beta-CD) based formulation has been proposed.	Cyclodextrins	98-110	beta-carotene oxygenase 1	Mus musculus	116-123
31047663-3	2019	Porous structure, large extent of carboxylic functional groups, cyclodextrin"s preventing aggregation, and negatively charged make P-CDP-COO- possess an outstanding adsorption capability for lysozyme.	Cyclodextrins	64-76	lysozyme	Homo sapiens	191-199
31048240-8	2019	Our results also show the differential extents of interaction of various CDs (alpha-CD, beta-CD, methyl-beta-CD, and gamma-CD) with DMPG leading to varying degrees of release of the bound-dye molecule.	Cyclodextrins	73-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-86
31048240-8	2019	Our results also show the differential extents of interaction of various CDs (alpha-CD, beta-CD, methyl-beta-CD, and gamma-CD) with DMPG leading to varying degrees of release of the bound-dye molecule.	Cyclodextrins	73-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	88-95
31048240-8	2019	Our results also show the differential extents of interaction of various CDs (alpha-CD, beta-CD, methyl-beta-CD, and gamma-CD) with DMPG leading to varying degrees of release of the bound-dye molecule.	Cyclodextrins	73-76	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	104-111
30882968-4	2019	By reversed phase chromatography, we obtained single CD samples composed of 10 to 12 glucose units (CD10, CD11, and CD12) with a purity of >90 %.	Cyclodextrins	53-55	membrane metalloendopeptidase	Homo sapiens	100-104
30847936-2	2019	The tested cyclodextrin was the versatile sulfobutylether- beta-CD, used either in a phosphate buffer using capillaries dynamically coated with polyethylene oxide or in a borate buffer using uncoated capillaries.	Cyclodextrins	11-23	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	59-66
30709900-0	2019	Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells.	Cyclodextrins	0-12	mucolipin TRP cation channel 1	Homo sapiens	22-28
30709900-0	2019	Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells.	Cyclodextrins	0-12	protein interacting with PRKCA 1	Homo sapiens	74-78
30709900-3	2019	In addition, evidence is also accumulating that low concentrations of cyclodextrins reduce the cholesterol-storage phenotype in cells and animals with the cholesterol storage disease Niemann-Pick type C, via an unknown mechanism.	Cyclodextrins	70-83	protein interacting with PRKCA 1	Homo sapiens	191-195
30709900-4	2019	Here, we report that cyclodextrin triggers the secretion of the endo/lysosomal content in nonspecialized cells and that this mechanism is responsible for the decreased cholesterol overload in Niemann-Pick type C cells.	Cyclodextrins	21-33	protein interacting with PRKCA 1	Homo sapiens	200-204
32104451-0	2019	Cyclodextrin/chitosan nanoparticles for oral ovalbumin delivery: Preparation, characterization and intestinal mucosal immunity in mice.	Cyclodextrins	0-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	45-54
30366544-1	2019	Cyclodextrin complex of nintedanib was prepared aiming for increased bio-activity and improved transport across intestinal membrane with reduced p-glycoprotein (p-gp) efflux.	Cyclodextrins	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	145-159
30366544-1	2019	Cyclodextrin complex of nintedanib was prepared aiming for increased bio-activity and improved transport across intestinal membrane with reduced p-glycoprotein (p-gp) efflux.	Cyclodextrins	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	161-165
30366544-8	2019	Interestingly, complexation has increased transport of nintedanib across intestinal membrane and reduced efflux ratio, suggesting the role of cyclodextrin complexation in modulating p-gp efflux.	Cyclodextrins	142-154	ATP binding cassette subfamily B member 1	Homo sapiens	182-186
30342014-7	2019	Hydroxypropyl-beta-cyclodextrin is too bulky to enter MPO channel leading to the binding site suggesting a full release of curcumin from the cyclodextrin thereby allowing its full access to the active site of MPO.	Cyclodextrins	19-31	myeloperoxidase	Homo sapiens	54-57
30342014-7	2019	Hydroxypropyl-beta-cyclodextrin is too bulky to enter MPO channel leading to the binding site suggesting a full release of curcumin from the cyclodextrin thereby allowing its full access to the active site of MPO.	Cyclodextrins	19-31	myeloperoxidase	Homo sapiens	209-212
30358440-0	2019	Cyclodextrins reduce the ability of Pseudomonas aeruginosa outer-membrane vesicles to reduce CFTR Cl- secretion.	Cyclodextrins	0-13	CF transmembrane conductance regulator	Homo sapiens	93-97
30358440-2	2019	Herein, we tested the hypothesis that a reduction of the cholesterol content of CF human airway epithelial cells by cyclodextrins reduces the inhibitory effect of OMVs on VX-809 (lumacaftor)-stimulated Phe508del CFTR Cl- secretion.	Cyclodextrins	116-129	CF transmembrane conductance regulator	Homo sapiens	212-216
30358440-5	2019	Both cyclodextrins reduced OMV inhibition of VX-809-stimulated Phe508del-CFTR Cl- secretion when added to the apical side of CF monolayers.	Cyclodextrins	5-18	CF transmembrane conductance regulator	Homo sapiens	73-77
30113825-5	2018	In this study, we confirm the prediction and determine the kinetic constants by using MA-ACE to analyze an intermolecular interaction between cyclodextrin and phenoxypropionic acid.	Cyclodextrins	142-154	angiotensin I converting enzyme	Homo sapiens	89-92
30216584-0	2019	Cyclodextrin-Based Macromolecular Systems as Cholesterol-Mopping Therapeutic Agents in Niemann-Pick Disease Type C. Over the last decade, cyclodextrins (CDs) have gained considerable attention as a potential therapeutic intervention in the treatment of the rare genetic condition Niemann-Pick type C disease (NPC).	Cyclodextrins	0-12	NPC intracellular cholesterol transporter 1	Homo sapiens	309-312
30216584-0	2019	Cyclodextrin-Based Macromolecular Systems as Cholesterol-Mopping Therapeutic Agents in Niemann-Pick Disease Type C. Over the last decade, cyclodextrins (CDs) have gained considerable attention as a potential therapeutic intervention in the treatment of the rare genetic condition Niemann-Pick type C disease (NPC).	Cyclodextrins	138-151	NPC intracellular cholesterol transporter 1	Homo sapiens	309-312
30216584-0	2019	Cyclodextrin-Based Macromolecular Systems as Cholesterol-Mopping Therapeutic Agents in Niemann-Pick Disease Type C. Over the last decade, cyclodextrins (CDs) have gained considerable attention as a potential therapeutic intervention in the treatment of the rare genetic condition Niemann-Pick type C disease (NPC).	Cyclodextrins	153-156	NPC intracellular cholesterol transporter 1	Homo sapiens	309-312
30216584-2	2019	CD-based macromolecular systems hold great promise to overcome such limitations and might provide an improved therapeutic approach in reducing cholesterol accumulation in NPC.	Cyclodextrins	0-2	NPC intracellular cholesterol transporter 1	Homo sapiens	171-174
30216584-3	2019	In the present article, the latest developments and synthetic strategies in the preparation of CD-containing polymers as cholesterol-mopping therapeutic agents in NPC are summarized.	Cyclodextrins	95-97	NPC intracellular cholesterol transporter 1	Homo sapiens	163-166
30809357-5	2019	Specifically, a chemiluminescence substrate and chemiluminescence fluorophore (antitumor drug, CPT) were co-encapsulated in host-guest carriers composed of cyclodextrin and the photoisomerization molecule azobenzene.	Cyclodextrins	156-168	choline phosphotransferase 1	Homo sapiens	95-98
31582656-0	2019	Hepatocyte-Targeted Delivery of siRNA Polyplex with PEG-Modified Lactosylated Dendrimer/Cyclodextrin Conjugates for Transthyretin-Related Amyloidosis Therapy.	Cyclodextrins	88-100	transthyretin	Homo sapiens	116-129
30274043-7	2018	Furthermore, doxorubicin released from biomaterials with cyclodextrin moderately induced the expression of tumor suppressor protein p53 whereas p21 expression was similar to control cells.	Cyclodextrins	57-69	tumor protein p53	Homo sapiens	132-135
30192846-3	2018	Subsequently, the preferred cyclodextrin prodrug moiety was appended to a number of CSF1R inhibitory active parent molecules, enabling GI-restricted delivery.	Cyclodextrins	28-40	colony stimulating factor 1 receptor	Mus musculus	84-89
29981896-0	2018	A stimuli-responsive insulin delivery system based on reversible phenylboronate modified cyclodextrin with glucose triggered host-guest interaction.	Cyclodextrins	89-101	insulin	Homo sapiens	21-28
29981896-5	2018	The drug carrier is composed of cyclodextrin, which can encapsulate insulin, and phenylboronate, which is sensitive to the cis-diols in some saccharides.	Cyclodextrins	32-44	insulin	Homo sapiens	68-75
29746956-0	2018	Liposomal delivery of a Pin1 inhibitor complexed with cyclodextrins as new therapy for high-grade serous ovarian cancer.	Cyclodextrins	54-67	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	24-28
30288206-0	2018	Cyclodextrin-Promoted Fluorescence Detection of Aromatic Toxicants and Toxicant Metabolites in Commercial Milk Products.	Cyclodextrins	0-12	Weaning weight-maternal milk	Bos taurus	106-110
29721086-10	2018	Conclusion: The in vivo distribution pattern of the cyclodextrin host could be guided by the pre-administration of the adamantane guest, thereby creating a direct link between the scout-scan (MAA-Ad) and delivery of therapy.	Cyclodextrins	52-64	MAA	Homo sapiens	192-195
29799507-7	2018	After the first application of BBP for mycotoxin binding, BBP could be completely reactivated through the elimination of ZEN from the cyclodextrin cavities by washing with a 50 v/v% ethanol-water mixture.	Cyclodextrins	134-146	TM2 domain containing 1	Homo sapiens	31-34
29799507-7	2018	After the first application of BBP for mycotoxin binding, BBP could be completely reactivated through the elimination of ZEN from the cyclodextrin cavities by washing with a 50 v/v% ethanol-water mixture.	Cyclodextrins	134-146	TM2 domain containing 1	Homo sapiens	58-61
29429726-0	2018	A sonochemical synthesis of cyclodextrin functionalized Au-FeNPs for colorimetric detection of Cr6+ in different industrial waste water.	Cyclodextrins	28-40	teratocarcinoma-derived growth factor 1 pseudogene 6	Homo sapiens	95-98
29854557-0	2018	Characterization of alpha-Glucosidase Inhibitor/Cyclodextrin Complex Prepared by Freeze-Drying.	Cyclodextrins	48-60	sucrase-isomaltase	Homo sapiens	20-37
28705503-5	2017	The loading amount of SEB-beta-CD were determined by the method of weight increment and photometric titration, respectively, and an average content of active SEB-beta-CD in our prepared hydrogel is more than 50%, much higher than the grafting of CD on biopolymers materials through chemical reaction.	Cyclodextrins	31-33	SET binding protein 1	Homo sapiens	22-25
29393635-3	2018	By incorporating cyclodextrin (Cyd)-adamantane (Ada), we synthesized Ada1 (PIP1-Ada) and Cyd1 (PIP2-Cyd), which were evaluated using Tm, EMSA, competitive, and SPR assays and molecular dynamics studies.	Cyclodextrins	17-29	transcriptional adaptor 1	Homo sapiens	69-73
29393635-3	2018	By incorporating cyclodextrin (Cyd)-adamantane (Ada), we synthesized Ada1 (PIP1-Ada) and Cyd1 (PIP2-Cyd), which were evaluated using Tm, EMSA, competitive, and SPR assays and molecular dynamics studies.	Cyclodextrins	17-29	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	75-79
29393635-3	2018	By incorporating cyclodextrin (Cyd)-adamantane (Ada), we synthesized Ada1 (PIP1-Ada) and Cyd1 (PIP2-Cyd), which were evaluated using Tm, EMSA, competitive, and SPR assays and molecular dynamics studies.	Cyclodextrins	31-34	transcriptional adaptor 1	Homo sapiens	69-73
29393635-3	2018	By incorporating cyclodextrin (Cyd)-adamantane (Ada), we synthesized Ada1 (PIP1-Ada) and Cyd1 (PIP2-Cyd), which were evaluated using Tm, EMSA, competitive, and SPR assays and molecular dynamics studies.	Cyclodextrins	31-34	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	75-79
29380439-1	2018	Precise molecular sieving architectures with Janus superhighways are constructed via a molecularly engineered interfacial reaction between cyclodextrin (CD) and trimesoyl chloride (TMC).	Cyclodextrins	139-151	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	181-184
29380439-1	2018	Precise molecular sieving architectures with Janus superhighways are constructed via a molecularly engineered interfacial reaction between cyclodextrin (CD) and trimesoyl chloride (TMC).	Cyclodextrins	153-155	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	181-184
29380439-2	2018	Interestingly, the CD/TMC nanofilms constructed with both hydrophobic inner cavities and hydrophilic channels exhibit exceptionally high permeances for both polar and nonpolar solvents.	Cyclodextrins	19-21	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	22-25
29380439-5	2018	Based on the rejection ratio of various dyes, the estimated molecular weight cutoff of CD/TMC nanofilms follows the trend of alpha-CD/TMC (320 Da) <beta-CD/TMC (400 Da) <gamma-CD/TMC (550 Da), which is in strict accordance with the orders of their free volumes measured by PAS and inner cavity sizes of alpha-CD <beta-CD <gamma-CD.	Cyclodextrins	87-89	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	90-93
29380439-5	2018	Based on the rejection ratio of various dyes, the estimated molecular weight cutoff of CD/TMC nanofilms follows the trend of alpha-CD/TMC (320 Da) <beta-CD/TMC (400 Da) <gamma-CD/TMC (550 Da), which is in strict accordance with the orders of their free volumes measured by PAS and inner cavity sizes of alpha-CD <beta-CD <gamma-CD.	Cyclodextrins	87-89	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	125-137
29380439-5	2018	Based on the rejection ratio of various dyes, the estimated molecular weight cutoff of CD/TMC nanofilms follows the trend of alpha-CD/TMC (320 Da) <beta-CD/TMC (400 Da) <gamma-CD/TMC (550 Da), which is in strict accordance with the orders of their free volumes measured by PAS and inner cavity sizes of alpha-CD <beta-CD <gamma-CD.	Cyclodextrins	87-89	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	151-162
29380439-5	2018	Based on the rejection ratio of various dyes, the estimated molecular weight cutoff of CD/TMC nanofilms follows the trend of alpha-CD/TMC (320 Da) <beta-CD/TMC (400 Da) <gamma-CD/TMC (550 Da), which is in strict accordance with the orders of their free volumes measured by PAS and inner cavity sizes of alpha-CD <beta-CD <gamma-CD.	Cyclodextrins	87-89	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	176-188
29380439-6	2018	This kind of novel CD/TMC molecular sieving membrane with intrinsic microporosity containing tunable pore size and sharp pore-size distribution can effectively discriminate molecules with different 3D sizes.	Cyclodextrins	19-21	STT3 oligosaccharyltransferase complex catalytic subunit A	Homo sapiens	22-25
29304403-5	2018	A highly biocompatible nano system for codelivery of the TRAIL DNA and the death receptor sensitizer monensin was developed, in which low-molecular-weight PEI (LMW-PEI) was crosslinked by the sulfhydryl cyclodextrin via disulfide bonds, and then bound with DNA, thus forming the bioreducible polyplex cores.	Cyclodextrins	203-215	TNF superfamily member 10	Homo sapiens	57-62
29417824-2	2018	We discuss examples of metalloprotein models (hemoglobin, superoxide dismutase and catalase) based on cyclodextrins.	Cyclodextrins	102-115	catalase	Homo sapiens	83-91
29369308-2	2018	To address this, we employed a photoswitchable microtubule inhibitor (Azo-CA4) that was physically loaded in cyclodextrin-bearing micellar nanocarriers through the host-guest interaction.	Cyclodextrins	109-121	carbonic anhydrase 4	Homo sapiens	74-77
29364646-0	2018	Design of pH-Responsive Polymer Monolith Based on Cyclodextrin Vesicle for Capture and Release of Myoglobin.	Cyclodextrins	50-62	myoglobin	Homo sapiens	98-107
32254267-1	2018	This article describes a novel reduction degradable supramolecular nanoparticle gene delivery system via host-guest interaction based on cyclodextrin-conjugated polyaspartamide with disulfide linkage (Pasp-SS-CD) and adamantyl-terminated polyethylenimine (Ad4-PEI).	Cyclodextrins	137-149	presenilin 2	Homo sapiens	256-259
29154400-2	2018	Several modified cyclodextrins (CDs) were applied for enantioseparation of racemates such as highly sulfated alpha, gamma CDs, hydroxyl propyl-beta-CD, and Sulfobutyl ether-beta-CD.	Cyclodextrins	17-30	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	143-150
29154400-2	2018	Several modified cyclodextrins (CDs) were applied for enantioseparation of racemates such as highly sulfated alpha, gamma CDs, hydroxyl propyl-beta-CD, and Sulfobutyl ether-beta-CD.	Cyclodextrins	17-30	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	173-180
29154400-2	2018	Several modified cyclodextrins (CDs) were applied for enantioseparation of racemates such as highly sulfated alpha, gamma CDs, hydroxyl propyl-beta-CD, and Sulfobutyl ether-beta-CD.	Cyclodextrins	32-35	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	143-150
29154400-2	2018	Several modified cyclodextrins (CDs) were applied for enantioseparation of racemates such as highly sulfated alpha, gamma CDs, hydroxyl propyl-beta-CD, and Sulfobutyl ether-beta-CD.	Cyclodextrins	32-35	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	173-180
29842826-0	2018	Effects of cyclodextrin on the stereoselectivity inhibition of acetylcholinesterase by isomalathion.	Cyclodextrins	11-23	acetylcholinesterase (Cartwright blood group)	Homo sapiens	63-83
28705503-5	2017	The loading amount of SEB-beta-CD were determined by the method of weight increment and photometric titration, respectively, and an average content of active SEB-beta-CD in our prepared hydrogel is more than 50%, much higher than the grafting of CD on biopolymers materials through chemical reaction.	Cyclodextrins	31-33	SET binding protein 1	Homo sapiens	158-161
28980319-7	2017	Thus, GT may cause interaction with various P-gp substrates, due to the combined effects of catechins and cyclodextrins.	Cyclodextrins	106-119	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	44-48
28980319-9	2017	In taking low-solubility drugs including low-solubility P-gp substrates, cyclodextrin-containing foods and beverages such as GT should be avoided.	Cyclodextrins	73-85	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	56-60
27917426-1	2017	We report here a supramolecular strategy to assemble a cyclodextrin-functionalized anticancer Ru(ii) complex with an adamantane-appended tumor-targeting peptide into discrete and stable phosphorescent nanostructures that can induce cell death in integrin alphavbeta3-rich tumor cells with high selectivity.	Cyclodextrins	55-67	integrin subunit alpha V	Homo sapiens	246-266
29068527-1	2017	A cationic cyclodextrin was used as dynamic coating for the capillary electrophoresis of a model mixture of proteins (i.e., ubiquitin, alpha-lactoglobulin, cytochrome-c, and myoglobin) as positively charged species in a fused silica capillary.	Cyclodextrins	11-23	cytochrome c, somatic	Homo sapiens	156-168
29029741-1	2017	A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-beta-CD onto alkynyl silica via click chemistry.	Cyclodextrins	15-27	cyclin dependent kinase 1	Homo sapiens	94-99
29029741-1	2017	A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-beta-CD onto alkynyl silica via click chemistry.	Cyclodextrins	15-27	regulator of calcineurin 1	Homo sapiens	110-114
29029741-1	2017	A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-beta-CD onto alkynyl silica via click chemistry.	Cyclodextrins	29-31	cyclin dependent kinase 1	Homo sapiens	94-99
29029741-1	2017	A novel native cyclodextrin (CD) chiral stationary phase (CSP) with single triazole-bridge at CD C2 position (CSP1) was prepared by anchoring mono(2A-azido-2A-deoxy)-beta-CD onto alkynyl silica via click chemistry.	Cyclodextrins	29-31	regulator of calcineurin 1	Homo sapiens	110-114
28073164-5	2017	Cyclodextrin-induced depletion of FC transactivated Delta-6 desaturase by increasing sterol regulatory element-binding protein 2 expression in cultured hepatocytes.	Cyclodextrins	0-12	fatty acid desaturase 2	Mus musculus	52-70
28073164-5	2017	Cyclodextrin-induced depletion of FC transactivated Delta-6 desaturase by increasing sterol regulatory element-binding protein 2 expression in cultured hepatocytes.	Cyclodextrins	0-12	sterol regulatory element binding factor 2	Mus musculus	85-128
32263691-5	2017	Core:shell PCL:pPR fibers were then prepared by coaxial electrospinning in order to bring available reactive hydroxyl groups from the CD to the fiber surface.	Cyclodextrins	134-136	PPR1	Homo sapiens	15-18
28675505-1	2017	Supramolecular interactions between beta-lapachone (beta-lap) and cyclodextrins (CDs) were investigated by isothermal titration calorimetry.	Cyclodextrins	66-79	LAP	Homo sapiens	41-44
28675505-3	2017	Phase solubility diagrams showed beta-, HP-beta-, SBE-beta-, gamma-, and HP-gamma-CDs at 1.5% (w/w) allowed an increase in apparent solubility of beta-lap with enhancement factors of 12.0, 10.1, 11.8, 2.4, and 2.2, respectively.	Cyclodextrins	81-85	LAP	Homo sapiens	151-154
28675505-5	2017	Thermodynamic analysis suggests a hydrophobic interaction associated with the displacement of water from the cavity of the CD by the beta-lap.	Cyclodextrins	123-125	LAP	Homo sapiens	138-141
29029741-4	2017	CSP2 with normal CD orientation affords best separation for isoxazolines while CSP1 with reversed CD orientation better separates naringenin, hesperetin and Troger"s base.	Cyclodextrins	17-19	regulator of calcineurin 2	Homo sapiens	0-4
29029741-4	2017	CSP2 with normal CD orientation affords best separation for isoxazolines while CSP1 with reversed CD orientation better separates naringenin, hesperetin and Troger"s base.	Cyclodextrins	98-100	regulator of calcineurin 1	Homo sapiens	79-83
28890957-0	2017	Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2.	Cyclodextrins	47-59	syntaxin 2	Homo sapiens	116-120
28890957-1	2017	Using amphiphilic cyclodextrin as a scaffold, the first class of PK-glycoconjugates capable of high avidity binding to both Stx1 and Stx2 toxins in solid-phase assay formats is reported.	Cyclodextrins	18-30	syntaxin 1A	Homo sapiens	124-128
28890957-1	2017	Using amphiphilic cyclodextrin as a scaffold, the first class of PK-glycoconjugates capable of high avidity binding to both Stx1 and Stx2 toxins in solid-phase assay formats is reported.	Cyclodextrins	18-30	syntaxin 2	Homo sapiens	133-137
28920087-5	2017	Concerning CD-based materials employed for the first time for the removal of fungicides from polycontaminated aqueous solutions, results were interesting in particular for hydroxypropyl-beta-CDP: 1 g of adsorbent placed in 1 L of solution containing 1 mg of each of five triazoles (5 mg in total) was able to remove over half of the fungicide amount (2.97 mg).	Cyclodextrins	11-13	cut like homeobox 1	Homo sapiens	191-194
28325342-0	2017	Cyclodextrin-based sustained and controllable release system of insulin utilizing the combination system of self-assembly PEGylation and polypseudorotaxane formation.	Cyclodextrins	0-12	insulin	Homo sapiens	64-71
28325342-3	2017	So far, we also demonstrated that covalently PEGylated insulin forms polypseudorotaxanes (PPRXs) with cyclodextrins (PPRX technology).	Cyclodextrins	102-115	insulin	Homo sapiens	55-62
28325342-6	2017	In addition, SPRA-insulin/cyclodextrin PPRXs provided sustained and controllable release of insulin beyond the each single technology both in vitro and in vivo.	Cyclodextrins	26-38	insulin	Homo sapiens	92-99
28503206-2	2017	Rotating frame NOE experiments (ROESY) showed the same geometry of inclusion for both 1/beta-CD and 2/beta-CD complexes, with the aromatic ring system entering the cavity from the large rim of the cyclodextrin and the alkylammonium chain protruding out of the cavity and facing the secondary OH rim.	Cyclodextrins	197-209	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	88-101
28347782-5	2017	Hydroxypropyl-beta-Cyclodextrin (HPbetaCD) was the best CD studied for encapsulating t10,c12-CLA.	Cyclodextrins	39-41	selectin P ligand	Homo sapiens	93-96
28146632-5	2017	In this study an antibody targeted cyclodextrin-based nanoparticle (NP) (CD.DSPE-PEG-Fab) was developed for siRNA delivery specifically to AML LSCs.	Cyclodextrins	35-47	FA complementation group B	Homo sapiens	85-88
29230268-5	2017	The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin.	Cyclodextrins	248-260	matrix metallopeptidase 2	Homo sapiens	77-82
27826032-7	2017	Disruption of lipid rafts with cyclodextrin, however, prevented TbetaRI downregulation.	Cyclodextrins	31-43	transforming growth factor beta receptor 1	Homo sapiens	64-71
27720964-4	2017	In this study, to enhance the wound-healing properties of sacran hydrogel film (Sac-HGF) further, we fabricated and characterized novel Sac-HGFs containing cyclodextrins (CyDs).	Cyclodextrins	156-169	hepatocyte growth factor	Mus musculus	84-87
29230268-5	2017	The good inhibition effect of the dried extract on the AGE formation and the MMP-2 and MMP-9 activity is presumably due to a synergic effect exerted by both anthocyanin and bioflavonoid extract compounds and was improved by the use of alginate and cyclodextrin.	Cyclodextrins	248-260	matrix metallopeptidase 9	Homo sapiens	87-92
29230268-0	2017	An Alginate/Cyclodextrin Spray Drying Matrix to Improve Shelf Life and Antioxidant Efficiency of a Blood Orange By-Product Extract Rich in Polyphenols: MMPs Inhibition and Antiglycation Activity in Dysmetabolic Diseases.	Cyclodextrins	12-24	matrix metallopeptidase 2	Homo sapiens	152-156
27389146-0	2016	Folate-targeted amphiphilic cyclodextrin.siRNA nanoparticles for prostate cancer therapy exhibit PSMA mediated uptake, therapeutic gene silencing in vitro and prolonged circulation in vivo.	Cyclodextrins	28-40	folate hydrolase 1	Homo sapiens	97-101
27834854-2	2016	Previously, we demonstrated that BALB/c-npc1nihNpc1-/- mice treated with miglustat, cyclodextrin and allopregnanolone generally performed better than untreated Npc1-/- animals.	Cyclodextrins	84-96	NPC intracellular cholesterol transporter 1	Mus musculus	47-51
27841388-2	2016	Subsequent carbonization and thermal treatment of CD-MOF-2, the cyclodextrin metal-organic framework, afforded a carbon molecular sieve with a uniform and reduced pore size of ca.	Cyclodextrins	64-76	lysine acetyltransferase 8	Homo sapiens	53-56
27886123-1	2016	A "two birds, one stone" strategy was developed via a one-pot click reaction to simultaneously prepare a novel cyclodextrin (CD) dimer based aggregation induced emission (AIE) sensor (AIE-DCD) and a monomer based chiral stationary phase (CSP-MCD) for chiral high performance liquid chromatography (CHPLC).	Cyclodextrins	111-123	dermcidin	Homo sapiens	188-191
27389146-1	2016	In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA).	Cyclodextrins	33-45	folate hydrolase 1	Homo sapiens	153-187
27389146-1	2016	In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA).	Cyclodextrins	33-45	folate hydrolase 1	Homo sapiens	189-193
27389146-1	2016	In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA).	Cyclodextrins	47-49	folate hydrolase 1	Homo sapiens	153-187
27389146-1	2016	In this study, a folate targeted cyclodextrin (CD) nanoparticle was prepared by co-formulating CD.siRNA complexes with DSPE-PEG5000-folate to target the prostate specific membrane antigen (PSMA).	Cyclodextrins	47-49	folate hydrolase 1	Homo sapiens	189-193
27389146-7	2016	This study highlights the ability of incorporating a folate ligand into CD.siRNA nanoparticles to allow for targeted delivery of siRNA to prostate cancer cells via the PSMA.	Cyclodextrins	72-74	folate hydrolase 1	Homo sapiens	168-172
27714322-5	2016	The thermodynamic studies indicate that the inclusion of TTP into the cyclodextrin cavity is mainly an enthalpy-driven process.	Cyclodextrins	70-82	ZFP36 ring finger protein	Homo sapiens	57-60
27206754-9	2016	The use of organic solvent or cyclodextrin to improve the PCB availability in soil did not enhance degradation efficiency, underscoring the strong impact of soil matrix.	Cyclodextrins	30-42	pyruvate carboxylase	Homo sapiens	58-61
27488900-4	2016	Furthermore, the apoptotic and cytotoxic effects of blank amphiphilic CDs were demonstrated by various mechanistic methods including Caspase-8 activity, lipid peroxidation assay, TUNEL assay, Tali( )-based image analysis, cholesterol assay, and gene expression studies.	Cyclodextrins	70-73	caspase 8	Homo sapiens	133-142
27714323-1	2016	Soft mesoporous hierarchically structured particles were created by the self-assembly of an amphiphilic deep cavitand cyclodextrin betaCD-nC10 (degree of substitution n = 7.3), with a nanocavity grafted by multiple alkyl (C10) chains on the secondary face of the betaCD macrocycle through enzymatic biotransesterification, and the nonlamellar lipid monoolein (MO).	Cyclodextrins	118-130	homeobox C10	Homo sapiens	139-142
27482889-5	2016	TNF-induced albuminuria was aggravated in mice with podocyte-specific ABCA1 deficiency and was partially prevented by cholesterol depletion with cyclodextrin.	Cyclodextrins	145-157	tumor necrosis factor	Mus musculus	0-3
27548771-2	2016	TK-1 was designed to have hydrophilic cyclodextrin molecules and, thus, for higher water solubility and smaller particle sizes than the plasma protein-bound ICG.	Cyclodextrins	38-50	thymidine kinase 1	Rattus norvegicus	0-4
27235978-0	2016	Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice.	Cyclodextrins	24-36	regulatory associated protein of MTOR, complex 1	Mus musculus	108-117
27235978-0	2016	Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice.	Cyclodextrins	24-36	CREB regulated transcription coactivator 1	Mus musculus	145-151
26502027-1	2016	The dosing of drugs in an aqueous cyclodextrin formulation requires sufficient amount of cyclodextrins to fully solubilize the drug, as described by Stella"s cyclodextrin utility number (UCD).	Cyclodextrins	34-46	developmental pluripotency associated 3	Homo sapiens	149-155
26502027-1	2016	The dosing of drugs in an aqueous cyclodextrin formulation requires sufficient amount of cyclodextrins to fully solubilize the drug, as described by Stella"s cyclodextrin utility number (UCD).	Cyclodextrins	89-102	developmental pluripotency associated 3	Homo sapiens	149-155
26502027-1	2016	The dosing of drugs in an aqueous cyclodextrin formulation requires sufficient amount of cyclodextrins to fully solubilize the drug, as described by Stella"s cyclodextrin utility number (UCD).	Cyclodextrins	89-101	developmental pluripotency associated 3	Homo sapiens	149-155
27282534-2	2016	In this study, two novel amphiphilic cyclodextrins (FCD-1 and FCD-2) conjugated with folate group to enable active targeting to folate positive breast tumors were introduced.	Cyclodextrins	37-50	FECD2	Homo sapiens	52-57
27282534-2	2016	In this study, two novel amphiphilic cyclodextrins (FCD-1 and FCD-2) conjugated with folate group to enable active targeting to folate positive breast tumors were introduced.	Cyclodextrins	37-50	FECD3	Homo sapiens	62-67
27272478-2	2016	We propose a simple procedure to characterize the physicochemical properties of amorphous new coordination compounds between cyclodextrins (CD) and Cu(2+) salts, by means of the integration of the information provided by several techniques including elemental analysis, flame atomic absorption, TGA, UV-Vis diffuse reflectance, colorimetry, FT-IR and EPR.	Cyclodextrins	125-138	T-box transcription factor 1	Homo sapiens	295-298
27030885-6	2016	In this Tutorial Review, we describe our efforts of late in developing the fundamental principles and practical applications of a new copper-free click reaction - namely, cooperative capture synthesis, whereby introducing a cyclodextrin (CD) as an accelerator in CB-AAC, hydrogen bonding networks are formed between the rims of CD and CB6 in a manner that is positively cooperative, giving rise to a high level of pre-organisation during efficient and quick rotaxane formation.	Cyclodextrins	224-236	glycine-N-acyltransferase	Homo sapiens	266-269
27272478-2	2016	We propose a simple procedure to characterize the physicochemical properties of amorphous new coordination compounds between cyclodextrins (CD) and Cu(2+) salts, by means of the integration of the information provided by several techniques including elemental analysis, flame atomic absorption, TGA, UV-Vis diffuse reflectance, colorimetry, FT-IR and EPR.	Cyclodextrins	140-142	T-box transcription factor 1	Homo sapiens	295-298
27058612-6	2016	CSP1 with an electron-rich phenyl substitution on the CD rims gave a better resolution for isoxazolines whereas CSP2 with an electron-deficient phenyl substitution on the CD rims gave better resolution for flavonoids.	Cyclodextrins	54-56	regulator of calcineurin 1	Homo sapiens	0-4
27037956-3	2016	This review overviews, for the first time, the use of cyclodextrins and their derivatives as antiaggregant agents in a number of proteins (e.g., amyloid-beta, insulin, recombinant human growth hormone, prion protein, transthyretin, and alpha-synuclein) and some multimeric enzymes.	Cyclodextrins	54-67	insulin	Homo sapiens	159-166
27037956-3	2016	This review overviews, for the first time, the use of cyclodextrins and their derivatives as antiaggregant agents in a number of proteins (e.g., amyloid-beta, insulin, recombinant human growth hormone, prion protein, transthyretin, and alpha-synuclein) and some multimeric enzymes.	Cyclodextrins	54-67	growth hormone 1	Homo sapiens	186-200
25447754-0	2016	Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4 -induced hepatotoxicity in rats.	Cyclodextrins	50-62	C-C motif chemokine ligand 4	Rattus norvegicus	83-87
27058612-6	2016	CSP1 with an electron-rich phenyl substitution on the CD rims gave a better resolution for isoxazolines whereas CSP2 with an electron-deficient phenyl substitution on the CD rims gave better resolution for flavonoids.	Cyclodextrins	171-173	regulator of calcineurin 1	Homo sapiens	0-4
27058612-6	2016	CSP1 with an electron-rich phenyl substitution on the CD rims gave a better resolution for isoxazolines whereas CSP2 with an electron-deficient phenyl substitution on the CD rims gave better resolution for flavonoids.	Cyclodextrins	171-173	regulator of calcineurin 2	Homo sapiens	112-116
27058612-7	2016	Among isoxazolines, 4ClPh-OPr gained a high selectivity and resolution up to 18.6 and 38.7, respectively, which is an amazing result for CD enantioseparation materials.	Cyclodextrins	137-139	calcium binding protein, spermatid associated 1	Homo sapiens	21-25