PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9706464-1	1998	An in vitro normal human epidermal keratinocytes (NHEK) model was used to study and to characterize the protease stimulated by the mustards 2-chloroethyl ethyl sulphide (CEES), 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (nitrogen mustard, HN2), and Bis-2-chloroethyl sulfide (sulfur mustard, HD).	cees	170-174	MT-RNR2 like 2 (pseudogene)	Homo sapiens	256-259
10227578-3	1999	The binding of the TATA binding protein (TBP) to the TATA element was also inhibited by HN2, whereas sulphur mustard and the monofunctional sulphur mustard 2-chloroethyl ethyl sulphide (CEES) resulted in a disproportional extent of inhibition with respect to the level of alkylation.	cees	186-190	TATA-box binding protein	Homo sapiens	19-39
10227578-3	1999	The binding of the TATA binding protein (TBP) to the TATA element was also inhibited by HN2, whereas sulphur mustard and the monofunctional sulphur mustard 2-chloroethyl ethyl sulphide (CEES) resulted in a disproportional extent of inhibition with respect to the level of alkylation.	cees	186-190	TATA-box binding protein	Homo sapiens	41-44
10227578-3	1999	The binding of the TATA binding protein (TBP) to the TATA element was also inhibited by HN2, whereas sulphur mustard and the monofunctional sulphur mustard 2-chloroethyl ethyl sulphide (CEES) resulted in a disproportional extent of inhibition with respect to the level of alkylation.	cees	186-190	MT-RNR2 like 2 (pseudogene)	Homo sapiens	88-91
12208782-7	2002	PDK1, an upstream effector of Akt, was also down-regulated following CEES exposure, but two other upstream effectors of Akt, PI3-K and PDK2, remained unchanged.	cees	69-73	pyruvate dehydrogenase kinase 1	Homo sapiens	0-4
17137498-10	2006	Western blots showed that CEES transiently decreased the expression of iNOS protein; however, treatment of active iNOS with CEES in vitro did not inhibit its enzymatic activity CONCLUSION: CEES inhibits NO production in LPS stimulated macrophages by decreasing iNOS protein expression.	cees	26-30	nitric oxide synthase 2, inducible	Mus musculus	71-75
17137498-10	2006	Western blots showed that CEES transiently decreased the expression of iNOS protein; however, treatment of active iNOS with CEES in vitro did not inhibit its enzymatic activity CONCLUSION: CEES inhibits NO production in LPS stimulated macrophages by decreasing iNOS protein expression.	cees	26-30	nitric oxide synthase 2, inducible	Mus musculus	114-118
17137498-10	2006	Western blots showed that CEES transiently decreased the expression of iNOS protein; however, treatment of active iNOS with CEES in vitro did not inhibit its enzymatic activity CONCLUSION: CEES inhibits NO production in LPS stimulated macrophages by decreasing iNOS protein expression.	cees	26-30	nitric oxide synthase 2, inducible	Mus musculus	114-118
17137498-10	2006	Western blots showed that CEES transiently decreased the expression of iNOS protein; however, treatment of active iNOS with CEES in vitro did not inhibit its enzymatic activity CONCLUSION: CEES inhibits NO production in LPS stimulated macrophages by decreasing iNOS protein expression.	cees	124-128	nitric oxide synthase 2, inducible	Mus musculus	114-118
17137498-10	2006	Western blots showed that CEES transiently decreased the expression of iNOS protein; however, treatment of active iNOS with CEES in vitro did not inhibit its enzymatic activity CONCLUSION: CEES inhibits NO production in LPS stimulated macrophages by decreasing iNOS protein expression.	cees	124-128	nitric oxide synthase 2, inducible	Mus musculus	114-118
14769780-10	2004	The effects of CEES on the accumulation of ROS, the intracellular concentration of GSH, the mitochondrial membrane potential, and caspase-3 activity were all inhibited by pretreatment of cells with the GSH precursor N-acetyl cysteine or with GSH-ethyl ester.	cees	15-19	caspase 3	Homo sapiens	130-139
24976129-0	2014	Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells.	cees	11-15	8-oxoguanine DNA-glycosylase 1	Mus musculus	79-83
24976129-4	2014	Synergistic exposure of CEES and LPS provoked significant increase in phosphorylation of MAPKs, Akt, tuberin, that down regulate OGG1 expression and 8-OHdG accumulations.	cees	24-28	thymoma viral proto-oncogene 1	Mus musculus	96-99
24976129-4	2014	Synergistic exposure of CEES and LPS provoked significant increase in phosphorylation of MAPKs, Akt, tuberin, that down regulate OGG1 expression and 8-OHdG accumulations.	cees	24-28	TSC complex subunit 2	Mus musculus	101-108
24976129-4	2014	Synergistic exposure of CEES and LPS provoked significant increase in phosphorylation of MAPKs, Akt, tuberin, that down regulate OGG1 expression and 8-OHdG accumulations.	cees	24-28	8-oxoguanine DNA-glycosylase 1	Mus musculus	129-133
24976129-7	2014	Collectively, our results indicate that exposure of CEES and LPS induces oxidative stress and the activation of tuberin, and 8-OHdG accumulation via upstream signaling pathways including Akt and ERK1/2MAPK pathway in macrophages but not the down regulation of OGG1.	cees	52-56	TSC complex subunit 2	Mus musculus	112-119
24976129-7	2014	Collectively, our results indicate that exposure of CEES and LPS induces oxidative stress and the activation of tuberin, and 8-OHdG accumulation via upstream signaling pathways including Akt and ERK1/2MAPK pathway in macrophages but not the down regulation of OGG1.	cees	52-56	thymoma viral proto-oncogene 1	Mus musculus	187-190
24976129-7	2014	Collectively, our results indicate that exposure of CEES and LPS induces oxidative stress and the activation of tuberin, and 8-OHdG accumulation via upstream signaling pathways including Akt and ERK1/2MAPK pathway in macrophages but not the down regulation of OGG1.	cees	52-56	8-oxoguanine DNA-glycosylase 1	Mus musculus	260-264
12208782-7	2002	PDK1, an upstream effector of Akt, was also down-regulated following CEES exposure, but two other upstream effectors of Akt, PI3-K and PDK2, remained unchanged.	cees	69-73	AKT serine/threonine kinase 1	Homo sapiens	30-33
12208782-9	2002	The phosphorylation of Akt at Ser(473) and Thr(308) was significantly decreased following CEES treatment, reflecting the suppressed kinase activity of both PDK1 and PDK2.	cees	90-94	AKT serine/threonine kinase 1	Homo sapiens	23-26
12208782-9	2002	The phosphorylation of Akt at Ser(473) and Thr(308) was significantly decreased following CEES treatment, reflecting the suppressed kinase activity of both PDK1 and PDK2.	cees	90-94	pyruvate dehydrogenase kinase 1	Homo sapiens	156-160
12208782-9	2002	The phosphorylation of Akt at Ser(473) and Thr(308) was significantly decreased following CEES treatment, reflecting the suppressed kinase activity of both PDK1 and PDK2.	cees	90-94	pyruvate dehydrogenase kinase 2	Homo sapiens	165-169