PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 10080689-6 1999 Additional characterization of ACS6 gene expression indicated that the gene is also induced by wounding, and by treatment with LiCl, NaCl, CuCl2, auxin, cycloheximide (CHX), aminooxyacetic acid (AOA) and ethylene. cupric chloride 139-144 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6 Arabidopsis thaliana 31-35 10064141-9 1999 Like alkaline phosphatase, cyclic PIP-degrading enzymes require Mg2+ and they are inhibited by heavy metal ions such as mercuric and copper chloride, by sodium fluoride and interestingly, by prostaglandins. cupric chloride 133-148 prolactin induced protein Rattus norvegicus 34-37 10413500-10 1999 In addition, the human FGF-1 C131S mutant showed a decrease in homodimer formation when exposed to CuCl(2). cupric chloride 99-106 fibroblast growth factor 1 Homo sapiens 23-28 9287301-4 1997 Bovine S100b protein was found to suppress dose-dependently the hemolysis of mouse erythrocytes induced by CuCl2. cupric chloride 107-112 S100 calcium binding protein B Bos taurus 7-12 9437199-3 1997 We evaluated the production of platelet-activating factor (PAF), a potent inflammatory mediator, in human LDL subspecies on copper-initiated oxidation (4 mumol/L CuCl2, 80 micrograms/mL for hours at 37 degrees C). cupric chloride 162-167 PCNA clamp associated factor Homo sapiens 31-57 9437199-3 1997 We evaluated the production of platelet-activating factor (PAF), a potent inflammatory mediator, in human LDL subspecies on copper-initiated oxidation (4 mumol/L CuCl2, 80 micrograms/mL for hours at 37 degrees C). cupric chloride 162-167 PCNA clamp associated factor Homo sapiens 59-62 8733936-5 1996 Catalase and neocuproine nearly completely inhibited strand break formation induced by aromatic aldehydes/CuCl2. cupric chloride 106-111 catalase Homo sapiens 0-8 8951230-11 1996 FeCl(3) was ineffective, suggesting that CuCl(2) but not FeCl(3) mediates oxidation of PCB dihydroxy metabolites, resulting in oxidative DNA damage. cupric chloride 41-48 pyruvate carboxylase Homo sapiens 87-90 8951230-12 1996 The addition of catalase (100 U/mL) and sodium azide (0.1 M) reduced the effect of CuCl(2) (849 and 896 8-oxodG/10(6) nucleotides, respectively), while superoxide dismutase (600 U/mL) moderately stimulated and glutathione (100 microM) substantially stimulated 8-oxodG formation (3014 and 4415 8-oxodG/10(6) nucleotides, respectively). cupric chloride 83-90 catalase Homo sapiens 16-24 9051619-4 1997 Diethyldithiocarbamate (2 mM) inhibited CuZn SOD activity in supernatant fractions of muscle homogenates by 34% (P < 0.01, n = 5), an effect reversed by CuCl2 (2 mM). cupric chloride 156-161 superoxide dismutase 1 Rattus norvegicus 40-48 11666847-5 1996 [CuCl(Me(3)tpa)][CuCl(2)(Me(3)tpa)]ClO(4) (4) crystallized in the monoclinic system, space group P2(1)/a, with a = 15.698(6) A, b = 14.687(7) A, c = 19.475(4) A, beta = 97.13(2) degrees, and Z = 4 (R = 0.054, R(w) = 0.038). cupric chloride 17-24 H3 histone pseudogene 16 Homo sapiens 97-102 7627705-4 1995 Oxidation mediated by copper ions resulted in a significant inactivation of LDL-associated TFPI (60% to 72% at 24 hours with 2.5 mumol/l CuCl2). cupric chloride 137-142 tissue factor pathway inhibitor Homo sapiens 91-95 7546771-6 1995 The presence of cupric chloride in the culture medium during the incubation of the CdR cells for 16 h significantly enhanced lysyl oxidase activity accumulating in the medium, suggesting that lysyl oxidase deficiency in CdR cells may be related to abnormal copper metabolism. cupric chloride 16-31 lysyl oxidase Mus musculus 125-138 7546771-6 1995 The presence of cupric chloride in the culture medium during the incubation of the CdR cells for 16 h significantly enhanced lysyl oxidase activity accumulating in the medium, suggesting that lysyl oxidase deficiency in CdR cells may be related to abnormal copper metabolism. cupric chloride 16-31 lysyl oxidase Mus musculus 192-205 8491675-8 1993 A modified, direct-colouring AChE-method is presented, which uses copper chloride as source of cupric ions, acetylthiocholine chloride as substrate and 2-morpholinoethanesulphonic acid (MES) as buffer. cupric chloride 66-81 acetylcholinesterase Bos taurus 29-33 1428539-6 1992 The effectiveness of copper(II) chloride was confirmed also in the BOP-Cl method. cupric chloride 21-40 BOP Homo sapiens 67-70 1510681-3 1992 Mature brain-derived neurotrophic factor was extracted from E. coli inclusion bodies, refolded in the presence of CuCl2 and purified. cupric chloride 114-119 brain-derived neurotrophic factor Rattus norvegicus 7-40 34396788-7 2021 Incubation of osteoblasts with the OGR1 inhibitor CuCl2 inhibited the MET induced increase in RGS16 mRNA. cupric chloride 50-55 G protein-coupled receptor 68 Mus musculus 35-39 1399263-1 1992 Copper(II) chloride was found to be an extremely efficient racemization-suppressing additive in the DCC method as compared with the hitherto known ones, by employing the model coupling Z-Gly-L-Val-OH + H-L-Val-OMe in DMF. cupric chloride 0-19 DCC netrin 1 receptor Homo sapiens 100-103 27280676-0 1992 Accumulation of Isoflavones in Lupin Seedings Treated with Copper Chloride. cupric chloride 59-74 5'-nucleotidase, cytosolic IIIA Homo sapiens 31-36 33821628-4 2021 Here, we synthesize 0D chiral copper chloride hybrids, templated by chiral methylbenzylammonium (R/S-MBA), i.e., (R-/S-MBA)2CuCl4, that display circular dichroism for the ligand-to-metal charge transfer transition with an absorption anisotropy factor (gCD) among the largest reported for chiral metal halide semiconductor hybrids. cupric chloride 30-45 guanylate cyclase 2E, pseudogene Homo sapiens 252-255 34898033-5 2022 Moreover, a CuCl2 @MOF-867 based probe demonstrated highly selective and sensitive aqueous phase recognition of CN- ions even in the presence of other interfering anions such as Br- , NO3 - , I- , SO4 2- , OAc- , SCN- , NO2 - , etc. cupric chloride 12-17 sorcin Homo sapiens 178-223 33762296-7 2021 After treatment with CuCl2 followed by DTC for 15 min, the levels of CuET and Cu2+ in hCTR1-overexpressed cells was 2.5-fold higher than that of vector group. cupric chloride 21-26 solute carrier family 31 member 1 Homo sapiens 86-91 34396788-7 2021 Incubation of osteoblasts with the OGR1 inhibitor CuCl2 inhibited the MET induced increase in RGS16 mRNA. cupric chloride 50-55 regulator of G-protein signaling 16 Mus musculus 94-99 33875094-7 2021 In contrast, in the control (CuCl2) treated samples showed mostly changes in inflammation mainly through regulation of the Nuclear Factor Kappa-light-chain-enhancer of Activated B-cells (NFkappaB). cupric chloride 29-34 nuclear factor kappa B subunit 1 Homo sapiens 187-195 34426160-0 2021 CuCl2-catalyzed inexpensive, faster and ligand/additive free synthesis of isoquinolin-1(2H)-one derivatives via the coupling-cyclization strategy: Evaluation of a new class of compounds as potential PDE4 inhibitors. cupric chloride 0-5 phosphodiesterase 4A Homo sapiens 199-203 34510751-3 2021 Herein, a novel Cu anchored on hollow carbon spheres catalysts (HCS/Cu-x, x represents the mass of CuCl2 added in the system) is designed with controllable copper/carbon heterogenous interfaces. cupric chloride 99-104 holocarboxylase synthetase Homo sapiens 64-67 34510751-3 2021 Herein, a novel Cu anchored on hollow carbon spheres catalysts (HCS/Cu-x, x represents the mass of CuCl2 added in the system) is designed with controllable copper/carbon heterogenous interfaces. cupric chloride 99-104 cut like homeobox 1 Homo sapiens 68-72 2715044-2 1989 Hepatic copper accumulation following intraperitoneal injection of cupric chloride resulted in a dose-dependent reduction in the density of catalase-containing peroxisomes. cupric chloride 67-82 catalase Rattus norvegicus 140-148 35266459-2 2022 Specifically, Pt1,2Cu bi/tri-atoms are prepared by reducing CuCl2 at preformed Pt1 atoms with ethanol inside a PDMS-PEG protective layer. cupric chloride 60-65 zinc finger protein 77 Homo sapiens 14-17 35266459-2 2022 Specifically, Pt1,2Cu bi/tri-atoms are prepared by reducing CuCl2 at preformed Pt1 atoms with ethanol inside a PDMS-PEG protective layer. cupric chloride 60-65 zinc finger protein 77 Homo sapiens 79-82 2620798-5 1989 Binding of Ni(II) to CAM in the presence of Ca(II) is inhibited slightly by added MnCl2 (50 microM) and very strongly by CuCl2 and ZnCl2 (10 microM). cupric chloride 121-126 calmodulin 1 Homo sapiens 21-24 2620798-5 1989 Binding of Ni(II) to CAM in the presence of Ca(II) is inhibited slightly by added MnCl2 (50 microM) and very strongly by CuCl2 and ZnCl2 (10 microM). cupric chloride 121-126 carbonic anhydrase 2 Homo sapiens 44-50 3335323-5 1988 It was not until shortly after intravenous administration of a cupric chloride solution during a 5-day period, at a total dose of 10 mg, that serum copper and ceruloplasmin levels increased and the anemia, leukopenia, and neutropenia resolved. cupric chloride 63-78 ceruloplasmin Homo sapiens 159-172 9946881-0 1988 Linear spin-(1/2 magnetic chains: Susceptibilities, correlation functions, and applications to (C6H11NH3)CuBr3 and deuterated CuCl2 cupric chloride 126-131 spindlin 1 Homo sapiens 7-16 7213864-4 1980 The reaction results in formation of RO and RO2 radicals destroying cytochrome P-450 CuCl2 (0,001 M) also destroys cytochrome P-450 in the absence of cumene hydroperoxide; the destruction process is characterized by two phases with different rate constants. cupric chloride 85-90 cytochrome P-450 Oryctolagus cuniculus 68-84 2866488-1 1985 A progressive reduction in the size of rat metallothionein-1 mRNA following induction by copper chloride or dexamethasone was demonstrated on RNA blots, and was shown to be due to shortening of the poly(A)-tail. cupric chloride 89-104 metallothionein 1 Rattus norvegicus 43-60 24458697-1 1984 Purified maize leaf phosphoenolpyruvate carboxylase (EC 4.1.1.31) was completely inactivated by several thiol-modifying reagents, including, CuCl2, CdCl2 and N-ethylmaleimide. cupric chloride 141-146 MLO-like protein 4 Zea mays 20-51 24458697-2 1984 The inactivation by CuCl2 could be reversed by dithiothreitol, suggesting the involvement of vicinal dithiols in the inactivation process.Complete inactivation of phosphoenolpyruvate carboxylase was correlated with the incorporation of two mol ((3)H)N-ethylmaleimide per 100-kilodalton subunit. cupric chloride 20-25 MLO-like protein 4 Zea mays 163-194 6263423-1 1981 The purified oligodendrocyte enzyme 2",3"-cyclic nucleotide 3"-phosphodiesterase (CNP) obtained from bovine, human and guinea pig brain was inhibited by theophylline, caffeine, cupric chloride and organomercurials using a spectrophotometric assay and 1 mM 2",3"- cyclic cytidylate as the substrate. cupric chloride 177-192 2',3'-cyclic nucleotide 3' phosphodiesterase Bos taurus 36-80 6263423-1 1981 The purified oligodendrocyte enzyme 2",3"-cyclic nucleotide 3"-phosphodiesterase (CNP) obtained from bovine, human and guinea pig brain was inhibited by theophylline, caffeine, cupric chloride and organomercurials using a spectrophotometric assay and 1 mM 2",3"- cyclic cytidylate as the substrate. cupric chloride 177-192 2',3'-cyclic nucleotide 3' phosphodiesterase Bos taurus 82-85 6328143-3 1984 Human erythrocyte CNP activity was reduced 75 percent by the organomercurial p-chloromercuriphenyl sulfonate (1 X 10(-4) M), 46 percent by thimerosal (1 X 10(-4) M) and 35 percent by cupric chloride (1 X 10(-3) M). cupric chloride 183-198 2',3'-cyclic nucleotide 3' phosphodiesterase Homo sapiens 18-21 6694001-6 1984 Injection of CuCl2 into -Cu mice resulted in significant increases in body and brain weight, elevations in serum copper and ceruloplasmin activities and hemoglobin levels. cupric chloride 13-18 ceruloplasmin Mus musculus 124-137 7213864-4 1980 The reaction results in formation of RO and RO2 radicals destroying cytochrome P-450 CuCl2 (0,001 M) also destroys cytochrome P-450 in the absence of cumene hydroperoxide; the destruction process is characterized by two phases with different rate constants. cupric chloride 85-90 cytochrome P-450 Oryctolagus cuniculus 115-131 34051663-9 2021 Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62. cupric chloride 36-41 beclin 1 Rattus norvegicus 110-118 17743969-2 1965 At 5 x 10(-7)M ferric chloride or 10(-8)M cupric chloride, breakdown of hiydrogen peroxide was significant at -11 degrees and -18 degrees but negligible at +1 degrees C. Ascorbic acid oxidation was faster in ice both with or without added metalion. cupric chloride 42-57 carboxylesterase 2 Homo sapiens 208-211 33930976-8 2021 The kinetic reaction equation of the CuCl2 volatilization process can be described by Power Low, G(alpha) = alpha1/15. cupric chloride 37-42 BCL2 related protein A1 Homo sapiens 108-117 34051663-9 2021 Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62. cupric chloride 36-41 microtubule-associated protein 1 light chain 3 alpha Rattus norvegicus 123-136 33571669-0 2021 The role of TGF-beta1/Smad3 signaling pathway and oxidative stress in the inhibition of osteoblast mineralization by copper chloride. cupric chloride 117-132 transforming growth factor beta 1 Homo sapiens 12-21 34051663-9 2021 Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62. cupric chloride 36-41 KH RNA binding domain containing, signal transduction associated 1 Rattus norvegicus 164-167 34051663-10 2021 Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated. cupric chloride 33-38 AKT serine/threonine kinase 1 Rattus norvegicus 93-96 34051663-10 2021 Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated. cupric chloride 33-38 AKT serine/threonine kinase 1 Rattus norvegicus 97-100 34051663-10 2021 Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated. cupric chloride 33-38 mechanistic target of rapamycin kinase Rattus norvegicus 108-112 34051663-10 2021 Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated. cupric chloride 33-38 mechanistic target of rapamycin kinase Rattus norvegicus 113-117 34051663-10 2021 Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated. cupric chloride 33-38 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 172-176 34051663-10 2021 Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated. cupric chloride 33-38 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 177-181 33571669-0 2021 The role of TGF-beta1/Smad3 signaling pathway and oxidative stress in the inhibition of osteoblast mineralization by copper chloride. cupric chloride 117-132 SMAD family member 3 Homo sapiens 22-27 33571669-2 2021 It indicates that the inactivated TGF-beta1/Smad3 pathway leads to osteoblast impairment by CuCl2. cupric chloride 92-97 transforming growth factor beta 1 Homo sapiens 34-43 33571669-2 2021 It indicates that the inactivated TGF-beta1/Smad3 pathway leads to osteoblast impairment by CuCl2. cupric chloride 92-97 SMAD family member 3 Homo sapiens 44-49 33462188-9 2021 Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta. cupric chloride 94-99 NLR family, pyrin domain containing 3 Mus musculus 31-36 33918312-9 2021 CuCl2 stabilized HIF-1alpha expression under normoxia in OECM-1 cells, and complex with DSF enhanced that effect. cupric chloride 0-5 hypoxia inducible factor 1 subunit alpha Homo sapiens 17-27 33461096-5 2021 HMGB1 dimerization was positively modulated by CuCl2 and H2O2. cupric chloride 47-52 high mobility group box 1 Homo sapiens 0-5 33461096-7 2021 Treatment of HEK293T cells with CuCl2 and H2O2 enhanced the oxidative self-dimerization of HMGB1, whereas this dimerization was inhibited in mutant HMGB1C106A cells. cupric chloride 32-37 high mobility group box 1 Homo sapiens 91-96 33461096-7 2021 Treatment of HEK293T cells with CuCl2 and H2O2 enhanced the oxidative self-dimerization of HMGB1, whereas this dimerization was inhibited in mutant HMGB1C106A cells. cupric chloride 32-37 high mobility group box 1 Homo sapiens 148-153 33462188-9 2021 Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta. cupric chloride 94-99 caspase 1 Mus musculus 148-157 33462188-9 2021 Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta. cupric chloride 94-99 interleukin 1 beta Mus musculus 168-185 31702204-1 2019 We report an experimental and theoretical study of the low-temperature specific heat C and magnetic susceptibility chi of the layered anisotropic triangular-lattice spin-1/2 Heisenberg antiferromagnets Cs_{2}CuCl_{4-x}Br_{x} with x=0, 1, 2, and 4. cupric chloride 208-212 spindlin 1 Homo sapiens 165-171 32745495-5 2020 Incubation of RBC with CuCl2 increased protein oxidation, lipid peroxidation, methemoglobin formation and lowered glutathione content. cupric chloride 23-28 hemoglobin subunit gamma 2 Homo sapiens 78-91 32432590-0 2020 Li2(Se2O5)(H2O)1.5 CuCl2, a salt-inclusion diselenite structurally based on tetranuclear Li4 complexes. cupric chloride 19-24 ATP binding cassette subfamily A member 12 Homo sapiens 0-3 32432590-0 2020 Li2(Se2O5)(H2O)1.5 CuCl2, a salt-inclusion diselenite structurally based on tetranuclear Li4 complexes. cupric chloride 19-24 lipase family member N Homo sapiens 89-92 31999107-1 2020 A new spin-1/2 frustrated antiferromagnet, Cu9O2(VO4)4Cl2, was synthesized via chemical vapor transport method that emulates mineral formation in volcanic fumaroles. cupric chloride 43-57 spindlin 1 Homo sapiens 6-14 31582212-0 2019 Anamorsin attenuates cupric chloride-induced dopaminergic neuronal cell death. cupric chloride 21-36 cytokine induced apoptosis inhibitor 1 Mus musculus 0-9 31582212-3 2019 In this study, we showed that overexpression of anamorsin protected MN9D dopaminergic neuronal cells from cupric chloride-induced death. cupric chloride 106-121 cytokine induced apoptosis inhibitor 1 Mus musculus 48-57 33434428-2 2021 The Cu-1/2 metalated peptides were synthesized by reacting 1/2 with CuCl2 and were characterized by LC-ESI-MS and HR-ESI-MS. Cu-1/2 exhibited high GRPR-binding affinities with IC50 values <3 nM, as measured in a competition assay using the GRPR-expressing human PC-3 prostate cancer cell line and [125I]I-Tyr4-BBN as the competing ligand. cupric chloride 68-73 immunoglobulin kappa variable 1-35 Mus musculus 4-10 33434428-2 2021 The Cu-1/2 metalated peptides were synthesized by reacting 1/2 with CuCl2 and were characterized by LC-ESI-MS and HR-ESI-MS. Cu-1/2 exhibited high GRPR-binding affinities with IC50 values <3 nM, as measured in a competition assay using the GRPR-expressing human PC-3 prostate cancer cell line and [125I]I-Tyr4-BBN as the competing ligand. cupric chloride 68-73 immunoglobulin kappa variable 1-35 Mus musculus 125-131 33379315-2 2020 Herein, the reaction of triarylantimony difluorides with benzofurans under aerobic conditions in 1,2-DCE, using 5 mol% Pd (OAc)2 and 2 eq. of CuCl2 at 80 C, produced a variety of 2-arylbenzofurans in moderate-to-high yields. cupric chloride 142-147 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 119-134 33084689-1 2020 Reduction of copper(ii) chloride using sodium ascorbate in the presence of pure sodium 5-nitro-tetrazolate (NaNT) forms copper(i) 5-nitrotetrazolate - a known initiatory explosive (DBX-1) - and the novel mixed-ligand copper(i) chloride 5-nitrotetrazolate coordination polymer Cu3Cl(N4C-NO2)2, as well as mixtures of both. cupric chloride 13-32 developing brain homeobox 1 Homo sapiens 181-186 32926024-6 2020 Accordingly, the levels of ER stress-related factors (especially, CHOP and GADD34) and of phosphorylated JNK increased upon CuCl2 and ZnCl2 co-treatment, whereas pre-treatment with seleno-l-methionine significantly suppressed these upregulations. cupric chloride 124-129 DNA-damage inducible transcript 3 Mus musculus 66-70 32926024-6 2020 Accordingly, the levels of ER stress-related factors (especially, CHOP and GADD34) and of phosphorylated JNK increased upon CuCl2 and ZnCl2 co-treatment, whereas pre-treatment with seleno-l-methionine significantly suppressed these upregulations. cupric chloride 124-129 protein phosphatase 1, regulatory subunit 15A Mus musculus 75-81 32926024-6 2020 Accordingly, the levels of ER stress-related factors (especially, CHOP and GADD34) and of phosphorylated JNK increased upon CuCl2 and ZnCl2 co-treatment, whereas pre-treatment with seleno-l-methionine significantly suppressed these upregulations. cupric chloride 124-129 mitogen-activated protein kinase 8 Mus musculus 105-108 32375703-6 2020 RESULTS: In mice, the stimulating effect of 100 nM CuCl2 is absent in the retinae from Cav2.3-deficient mice, but prominent in Cav2.3-competent mice. cupric chloride 51-56 calcium channel, voltage-dependent, R type, alpha 1E subunit Mus musculus 87-93 32375703-6 2020 RESULTS: In mice, the stimulating effect of 100 nM CuCl2 is absent in the retinae from Cav2.3-deficient mice, but prominent in Cav2.3-competent mice. cupric chloride 51-56 calcium channel, voltage-dependent, R type, alpha 1E subunit Mus musculus 127-133 30223654-1 2018 A new approach of finely tuning multinuclear clusters of metal-organic frameworks (MOFs) through symmetry-upgradingly isoreticular transformation was first presented and a bcu-type MOF, {[Cu4(mu4-O)Cl2(IN)4][CuCl2]} (NJU-Bai35; NJU-Bai for Nanjing University Bai group), with cluster [Cu4(mu4-O)Cl2(COO)4N4] of higher symmetry compared to the pristine MOF, was successfully synthesized. cupric chloride 208-213 lysine acetyltransferase 8 Homo sapiens 83-86 30768131-7 2019 Accordingly, we found that phosphorylated (ie, active) forms of SAPK/JNK (p46 and p54) are increased by CuCl2 and ZnCl2 co-treatment in hypothalamic neuronal mouse cells (GT1-7 cells). cupric chloride 104-109 mitogen-activated protein kinase 8 Mus musculus 69-72 30768131-7 2019 Accordingly, we found that phosphorylated (ie, active) forms of SAPK/JNK (p46 and p54) are increased by CuCl2 and ZnCl2 co-treatment in hypothalamic neuronal mouse cells (GT1-7 cells). cupric chloride 104-109 interferon-induced protein with tetratricopeptide repeats 2 Mus musculus 82-85 30768131-8 2019 Downstream factors of SAPK/JNK, phospho-c-Jun, and phospho-activating transcription factor 2 are also induced by CuCl2 and ZnCl2 co-treatment. cupric chloride 113-118 mitogen-activated protein kinase 8 Mus musculus 27-30 30768131-8 2019 Downstream factors of SAPK/JNK, phospho-c-Jun, and phospho-activating transcription factor 2 are also induced by CuCl2 and ZnCl2 co-treatment. cupric chloride 113-118 jun proto-oncogene Mus musculus 40-45 30768131-9 2019 Moreover, an inhibitor of the SAPK/JNK signaling pathway, SP600125, significantly suppressed neuronal cell death and activation of the SAPK/JNK signaling pathway induced by CuCl2 and ZnCl2 cotreatment. cupric chloride 173-178 mitogen-activated protein kinase 8 Mus musculus 35-38 30768131-9 2019 Moreover, an inhibitor of the SAPK/JNK signaling pathway, SP600125, significantly suppressed neuronal cell death and activation of the SAPK/JNK signaling pathway induced by CuCl2 and ZnCl2 cotreatment. cupric chloride 173-178 mitogen-activated protein kinase 8 Mus musculus 140-143 30768131-11 2019 On the basis of these results, our findings suggest that activation of ZnCl2-dependent SAPK/JNK signaling pathway is important in neuronal cell death, and CuCl2-induced oxidative stress triggers the activation of this pathway. cupric chloride 155-160 mitogen-activated protein kinase 8 Mus musculus 92-95 30627687-1 2019 The overall structure of dihydrate cupric chloride (CuCl2 * 2H2O) crystallization patterns in the presence of bovine serum albumin (BSA) in a Petri dish is influenced by dewetting. cupric chloride 52-64 albumin Homo sapiens 117-130 30223654-1 2018 A new approach of finely tuning multinuclear clusters of metal-organic frameworks (MOFs) through symmetry-upgradingly isoreticular transformation was first presented and a bcu-type MOF, {[Cu4(mu4-O)Cl2(IN)4][CuCl2]} (NJU-Bai35; NJU-Bai for Nanjing University Bai group), with cluster [Cu4(mu4-O)Cl2(COO)4N4] of higher symmetry compared to the pristine MOF, was successfully synthesized. cupric chloride 208-213 lysine acetyltransferase 8 Homo sapiens 181-184 30120852-9 2018 Functional analysis of these novel variants in five different cell lines lacking inherent ATP7B expression demonstrated sensitivity to CuCl2 -treatment, experiencing augmented cellular copper retention and decreased copper excretion as well as ceruloplasmin secretion to that of wildtype-ATP7B expressing cells. cupric chloride 135-140 ATPase copper transporting beta Homo sapiens 90-95 30120852-9 2018 Functional analysis of these novel variants in five different cell lines lacking inherent ATP7B expression demonstrated sensitivity to CuCl2 -treatment, experiencing augmented cellular copper retention and decreased copper excretion as well as ceruloplasmin secretion to that of wildtype-ATP7B expressing cells. cupric chloride 135-140 ceruloplasmin Homo sapiens 244-257 30120852-9 2018 Functional analysis of these novel variants in five different cell lines lacking inherent ATP7B expression demonstrated sensitivity to CuCl2 -treatment, experiencing augmented cellular copper retention and decreased copper excretion as well as ceruloplasmin secretion to that of wildtype-ATP7B expressing cells. cupric chloride 135-140 ATPase copper transporting beta Homo sapiens 288-293 30351077-2 2018 The general reaction between CuCl2 2H2O, LnCl3 6H2O, phenoxH, and NEt3 in a 1:2:2:4 molar ratio, in a solvent mixture comprising MeCN and MeOH, afforded brown crystals of a new family of [Cu3LnCl3(phenox)6(MeOH)3] clusters (Ln = Gd (1), Tb (2), Dy (3)) that possess an unprecedented [Cu3Ln(mu-NO)6]3+ "propeller"-like core. cupric chloride 29-39 tetraspanin 2 Homo sapiens 66-70 31245723-9 2018 Oxidative stress, simulated by the addition of CuCl2, leads to the formation of high molecular weight polymers of beta-amylase similar to those detected in vivo. cupric chloride 47-52 1,4-alpha-D-glucan maltohydrolase Hordeum vulgare 114-126 30234099-6 2018 Co-incubation of the metallodrugs with CuCl2 (a CTR1 substrate) increased the cytotoxic effects of both the Au(III) complex and cisplatin; while co-incubation with cimetidine (inhibitor of OCT2 and MATE) showed some effect only after 72 h incubation. cupric chloride 39-44 calcitonin receptor Homo sapiens 48-52 30234099-6 2018 Co-incubation of the metallodrugs with CuCl2 (a CTR1 substrate) increased the cytotoxic effects of both the Au(III) complex and cisplatin; while co-incubation with cimetidine (inhibitor of OCT2 and MATE) showed some effect only after 72 h incubation. cupric chloride 39-44 POU class 2 homeobox 2 Homo sapiens 189-193 29229814-3 2017 The SE2 backside reaction is favored as a trigger step for the dehydrogenation of AB by the MCl2 The SE2 reaction is found for 3d-transition-metal chlorides (e.g., FeCl2, CoCl2, NiCl2, CuCl2, and ZnCl2), while PdCl2 leads to the dehydrogenation of AB by a direct B-H sigma-bond activation, similar to most organometallic catalysts. cupric chloride 185-190 fucosyltransferase 2 Homo sapiens 4-7 29229814-3 2017 The SE2 backside reaction is favored as a trigger step for the dehydrogenation of AB by the MCl2 The SE2 reaction is found for 3d-transition-metal chlorides (e.g., FeCl2, CoCl2, NiCl2, CuCl2, and ZnCl2), while PdCl2 leads to the dehydrogenation of AB by a direct B-H sigma-bond activation, similar to most organometallic catalysts. cupric chloride 185-190 fucosyltransferase 2 Homo sapiens 101-104 28927334-7 2017 Moreover, CuCl2 dramatically enriched the extracellular matrices with collagen I, collagen III, transforming growth factor-beta1, vascular endothelial growth factor, and basic fibroblast growth factor via hypoxia-inducible factor-1alpha activation. cupric chloride 10-15 transforming growth factor, beta 1 Mus musculus 70-128 29234903-1 2017 BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. cupric chloride 79-96 solute carrier family 31 member 1 Homo sapiens 213-233 29234903-1 2017 BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells. cupric chloride 104-109 solute carrier family 31 member 1 Homo sapiens 213-233 28338141-3 2017 In contrast, the Cu(ii) and Mn(ii) complexes [CuCl2(L)] and [MnCl2(L)] are highly cytotoxic with EC50 values of 1.25 +- 0.01 muM and 20 +- 1 muM, respectively. cupric chloride 46-51 latexin Homo sapiens 125-128 28130615-0 2017 Age-dependent changes of cerebral copper metabolism in Atp7b -/- knockout mouse model of Wilson"s disease by [64Cu]CuCl2-PET/CT. cupric chloride 115-120 ATPase, Cu++ transporting, beta polypeptide Mus musculus 55-60 28130615-4 2017 The objective of this study was to explore the feasibility and use of copper-64 chloride ([64C]CuCl2) as a tracer for noninvasive assessment of age-dependent changes of cerebral copper metabolism in WD using an Atp7b -/- knockout mouse model of WD and positron emission tomography/computed tomography (PET/CT) imaging. cupric chloride 95-100 ATPase, Cu++ transporting, beta polypeptide Mus musculus 211-216 28130615-5 2017 Continuing from our recent study of biodistribution and radiation dosimetry of [64C]CuCl2 in Atp7b -/- knockout mice, PET quantitative analysis revealed low 64Cu radioactivity in the brains of Atp7b -/- knockout mice at 7th weeks of age, compared with 64Cu radioactivity in the brains of age- and gender-matched wild type C57BL/6 mice, at 24 h (h) post intravenous injection of [64C]CuCl2 as a tracer. cupric chloride 383-388 ATPase, Cu++ transporting, beta polypeptide Mus musculus 193-198 28533936-2 2017 [64Cu]PSMA-617 was synthesized by heating PSMA-617 with [64Cu]CuCl2 in buffer solution at 90 C for 5 min. cupric chloride 62-67 folate hydrolase 1 Homo sapiens 6-10 28533936-2 2017 [64Cu]PSMA-617 was synthesized by heating PSMA-617 with [64Cu]CuCl2 in buffer solution at 90 C for 5 min. cupric chloride 62-67 folate hydrolase 1 Homo sapiens 42-46 28130615-6 2017 Furthermore, age-dependent increase of 64Cu radioactivity was detected in the brains of Atp7b -/- knockout mice from the 13th to 21th weeks of age, based on the data derived from a longitudinal [64C]CuCl2-PET/CT study of Atp7b -/- knockout mice with orally administered [64Cu]CuCl2 as a tracer. cupric chloride 199-204 ATPase, Cu++ transporting, beta polypeptide Mus musculus 88-93 28130615-6 2017 Furthermore, age-dependent increase of 64Cu radioactivity was detected in the brains of Atp7b -/- knockout mice from the 13th to 21th weeks of age, based on the data derived from a longitudinal [64C]CuCl2-PET/CT study of Atp7b -/- knockout mice with orally administered [64Cu]CuCl2 as a tracer. cupric chloride 276-281 ATPase, Cu++ transporting, beta polypeptide Mus musculus 88-93 28338141-3 2017 In contrast, the Cu(ii) and Mn(ii) complexes [CuCl2(L)] and [MnCl2(L)] are highly cytotoxic with EC50 values of 1.25 +- 0.01 muM and 20 +- 1 muM, respectively. cupric chloride 46-51 latexin Homo sapiens 141-144 26032686-5 2015 We found that extrinsic expressing WT ATP7B reduced CuCl2-induced copper accumulation and enhanced cellular copper tolerance by accelerating copper excretion, which was selectively compromised by R778L and P992L mutations. cupric chloride 52-57 ATPase copper transporting beta Homo sapiens 38-43 28250280-6 2017 MgCl2, NiCl2, ZnCl2, CuCl2 and CaCl2 dose-dependently decreased agonist-induced YO-PRO-1 uptake via both human and mouse P2X7Rs. cupric chloride 21-26 lamin A/C Homo sapiens 83-88 27892491-9 2016 IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability. cupric chloride 98-103 interleukin 1 alpha Homo sapiens 0-9 27892491-9 2016 IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability. cupric chloride 98-103 C-X-C motif chemokine ligand 8 Homo sapiens 14-18 27892491-9 2016 IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability. cupric chloride 98-103 heat shock protein family A (Hsp70) member 1A Homo sapiens 20-26 27892491-9 2016 IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability. cupric chloride 98-103 FOS like 1, AP-1 transcription factor subunit Homo sapiens 31-36 27484443-2 2016 The reaction of CuCl2, HL 2HCl and triethylamine (NEt3) in a molar ratio of 1 : 1 : 3 in water was found to generate a novel organometallic tetrazole derivative Cu2L2Cl2. cupric chloride 16-21 tetraspanin 2 Homo sapiens 50-54 26247622-1 2015 Cu-mediated C-2 chlorination of indoles was accomplished with copper(ii) chloride through the use of a directing pyrimidyl protection group. cupric chloride 62-81 complement C2 Homo sapiens 12-15 27045752-0 2016 Copper Chloride Catalysis: Do mu4-Oxido Copper Clusters Play a Significant Role? cupric chloride 0-15 adaptor related protein complex 4 subunit mu 1 Homo sapiens 30-33 27045752-7 2016 It can be clearly demonstrated that mu4-oxido copper clusters of the formula [Cu4OCl6(solvent)4] are the main product from the reactions of CuCl2 2H2O and basic coreagents. cupric chloride 140-150 adaptor related protein complex 4 subunit mu 1 Homo sapiens 36-39 27045752-8 2016 As a final result of these experiments, it can be stated that mu4-oxido copper clusters most likely play an important role in the mechanism of copper chloride-catalyzed reactions. cupric chloride 143-158 adaptor related protein complex 4 subunit mu 1 Homo sapiens 62-65 26370442-3 2015 Reaction of H3L with CuCl2 forms a mononuclear copper(ii) [Cu(Cl)(H2L)(H2O)] (H2L-Cu(2+)) complex which is characterized by conventional techniques and quantum chemical calculations. cupric chloride 21-26 H3 clustered histone 2 Homo sapiens 12-15 26169410-1 2015 The in vitro activity of the aminoglycoside 6"-N-acetyltransferase type Ib [AAC(6")-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 muM. cupric chloride 105-110 aminoglycoside N(6')-acetyltransferase Klebsiella pneumoniae 72-74 26169410-1 2015 The in vitro activity of the aminoglycoside 6"-N-acetyltransferase type Ib [AAC(6")-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 muM. cupric chloride 105-110 aminoglycoside N(6')-acetyltransferase Klebsiella pneumoniae 76-86 26034833-6 2015 (c) The 6-endo product P1 is formed exclusively using a catalytic system consisting of CuCl and DMF, whereas a mixture of 6-endo product P1 and 5-exo product P2 in a ratio of ~1:1 is produced using CuCl2 and DMF as a catalytic system. cupric chloride 198-203 crystallin gamma F, pseudogene Homo sapiens 137-145 25108186-6 2014 The fibrosis of hIAPP was inhibited by CuCl2, CuSO4 and Cu(Gly)2 with a similar degree. cupric chloride 39-44 islet amyloid polypeptide Homo sapiens 16-21 25756315-1 2015 A mild and efficient methodology involving Pd(PPh3)4-catalyzed intramolecular cyclization of N-alkynyl alkyloxycarbamates with CuCl2 or CuBr2 for the synthesis of 4-halo-oxazolones was developed. cupric chloride 127-132 caveolin 1 Homo sapiens 46-50 25689591-2 2015 PdCl2(CH3CN)2 was used as the catalyst and CuCl2 as the oxidant under the balloon pressure of CO. cupric chloride 43-48 phosducin like 2 Homo sapiens 0-5 25293311-5 2014 Replacing copper(II) acetate by copper(II) chloride in the synthesis leads to compound [Cu(I)Cl(H2-1,3-bdpb)], which crystallizes in the orthorhombic crystal system, within the space group Pnma (no. cupric chloride 32-51 A-kinase anchoring protein 5 Homo sapiens 96-100 25294121-5 2014 Profound stabilities and optimised structures of (001)CuCl and (001)Cl configurations are discussed within the context of the functionality of CuCl2 as the chief chlorination and condensation catalyst of aromatic pollutants under conditions relevant to their formation in thermal systems, i.e. 400-1000 K, a total operating pressure of 1.0 atm and PCl2 = 10(-6)-10(-4) atm (1.0-100.0 ppm). cupric chloride 143-148 metal response element binding transcription factor 2 Homo sapiens 348-352 25745767-8 2014 In the present study, the influence of 1 nM solutions of GHK, GHK-Cu and CuCl2, on IGF-2-dependent TGF-beta1 secretion in normal human dermal fibroblasts cells was investigated. cupric chloride 73-78 insulin like growth factor 2 Homo sapiens 83-88 25745767-8 2014 In the present study, the influence of 1 nM solutions of GHK, GHK-Cu and CuCl2, on IGF-2-dependent TGF-beta1 secretion in normal human dermal fibroblasts cells was investigated. cupric chloride 73-78 transforming growth factor beta 1 Homo sapiens 99-108 25108186-8 2014 Moreover, approximative cytotoxicity-enhancing levels between CuCl2, CuSO4 and Cu(Gly)2 on hIAPP were also observed in INS-1 cells. cupric chloride 62-67 islet amyloid polypeptide Homo sapiens 91-96 25091475-12 2014 CONCLUSION: An increase in (64)Cu uptake induced by the expression of hCTR1 gene was demonstrated in vivo and in vitro, suggesting the potential use of hCTR1 gene as a new imaging reporter gene for PET with (64)CuCl2. cupric chloride 211-216 solute carrier family 31 member 1 Homo sapiens 70-75 25091475-12 2014 CONCLUSION: An increase in (64)Cu uptake induced by the expression of hCTR1 gene was demonstrated in vivo and in vitro, suggesting the potential use of hCTR1 gene as a new imaging reporter gene for PET with (64)CuCl2. cupric chloride 211-216 solute carrier family 31 member 1 Homo sapiens 152-157 25273418-1 2014 The cause for the preferred spin orientation in magnetic systems containing spin-1/2 transition-metal ions was explored by studying the origin of the easy-plane anisotropy of the spin-1/2 Cu(2+) ions in CuCl2 2H2O, LiCuVO4, CuCl2, and CuBr2 on the basis of density functional theory and magnetic dipole-dipole energy calculations as well as a perturbation theory treatment of the spin-orbit coupling. cupric chloride 203-208 spindlin 1 Homo sapiens 76-82 25273418-1 2014 The cause for the preferred spin orientation in magnetic systems containing spin-1/2 transition-metal ions was explored by studying the origin of the easy-plane anisotropy of the spin-1/2 Cu(2+) ions in CuCl2 2H2O, LiCuVO4, CuCl2, and CuBr2 on the basis of density functional theory and magnetic dipole-dipole energy calculations as well as a perturbation theory treatment of the spin-orbit coupling. cupric chloride 203-208 spindlin 1 Homo sapiens 76-84 24869914-0 2014 Magnetic anisotropy in a spin 1/2 quasi-one-dimensional antiferromagnetic copper(II) complex CuCl2(pdz) with a staggered g-tensor. cupric chloride 93-98 spindlin 1 Homo sapiens 25-33 24213945-4 2014 Here, we studied the effect of physiological concentration of CuCl2 (muM range) on the activity of peripheral neurons using a preparation of nodose ganglion in vitro. cupric chloride 62-67 latexin Homo sapiens 69-72 24901737-6 2014 An inductively coupled plasma optical emission spectrometry (ICP-OES) analysis illustrated that, compared to the wild type seedlings the Sali3-2-transgenic seedlings accumulated more cadmium or copper in the roots but less in the upper ground tissues when the seedlings were exposed to excessive CuCl2 or CdCl2 stress. cupric chloride 296-301 Sali3-2 Glycine max 137-144 24639459-12 2014 CONCLUSION: Overall, data indicated that hCtr1 is a promising theranostic target, which can be further developed for metabolic imaging of prostate cancer using (64)CuCl2 PET/CT and personalized cancer therapy targeting copper metabolism. cupric chloride 164-169 solute carrier family 31 member 1 Homo sapiens 41-46 24508213-4 2014 The new bivalent GRPr/PSMA targeting vector was purified by reversed-phase high performance liquid chromatography (RP-HPLC), characterized by electrospray-ionization mass spectrometry (ESI-MS), and metallated with (64)CuCl2 and (nat)CuCl2. cupric chloride 218-223 gastrin releasing peptide receptor Mus musculus 17-21 24508213-4 2014 The new bivalent GRPr/PSMA targeting vector was purified by reversed-phase high performance liquid chromatography (RP-HPLC), characterized by electrospray-ionization mass spectrometry (ESI-MS), and metallated with (64)CuCl2 and (nat)CuCl2. cupric chloride 233-238 gastrin releasing peptide receptor Mus musculus 17-21 23578282-2 2013 In the case of 2,2-dialkynyl-1,2-diols, bearing an additional alkynyl substituent at C-2, a cascade process, corresponding to copper-catalyzed heterocyclodehydration followed by acid-catalyzed hydration of the triple bond, was realized when the reaction was carried out in the presence of both CuCl2 and TsOH, leading to 3-acylfurans in one step and high yields (75-84%). cupric chloride 294-299 complement C2 Homo sapiens 85-88 24473150-3 2014 In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE. cupric chloride 63-78 acetylcholinesterase (Cartwright blood group) Homo sapiens 197-201 23391964-1 2013 The reactions of enantiopure chiral ligands (+)/(-)-4,5-pinenepyridyl-2-pyrazine (LS/LR) with CuCl2 2H2O in CH3OH/CH2Cl2 solution led to the formations of one-dimensional homochiral enantiomeric pairs with the formula [Cu(LR/S)Cl2]n 2H2O (R-1 and S-1, the isomers containing the LR and LS ligands, respectively). cupric chloride 94-104 CD1b molecule Homo sapiens 233-250 22239859-10 2012 In conclusion, these studies show that sublethal exposure to copper (as copper chloride) induces toxicity in the thymus and spleen, and increased Sub G0/G1 population among splenocytes and thymocytes that is mediated, in part, by the EndoG-Bax-ubiquitin pathway. cupric chloride 72-87 endonuclease G Mus musculus 234-239 23285694-9 2012 GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in fibroblasts. cupric chloride 10-15 tumor necrosis factor Homo sapiens 53-62 23285694-9 2012 GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in fibroblasts. cupric chloride 10-15 interleukin 6 Homo sapiens 73-77 22515166-10 2012 Combined treatment with 100 muM CuCl2 and 200 muM BZF (which are only marginally effective when administered individually) achieved complete rescue of COX activity in SCO2 cells. cupric chloride 32-37 cytochrome c oxidase subunit 8A Homo sapiens 151-154 22170165-5 2012 RESULTS: PET-CT analysis demonstrated higher (64)Cu radioactivity in the liver of Atp7b (-/-) knockout mice compared with that in the control C57BL WT mice (p < 0.001), following oral administration of (64)CuCl(2) as a tracer. cupric chloride 233-240 ATPase, Cu++ transporting, beta polypeptide Mus musculus 82-87 22170165-12 2012 CONCLUSIONS: PET-CT quantitative analysis demonstrated an increased level of (64)Cu radioactivity in the liver of Atp7b (-/-) KO mice compared with that in the control C57BL WT mice, following oral administration of (64)CuCl(2) as a tracer. cupric chloride 247-254 ATPase, Cu++ transporting, beta polypeptide Mus musculus 114-119 22239859-10 2012 In conclusion, these studies show that sublethal exposure to copper (as copper chloride) induces toxicity in the thymus and spleen, and increased Sub G0/G1 population among splenocytes and thymocytes that is mediated, in part, by the EndoG-Bax-ubiquitin pathway. cupric chloride 72-87 BCL2-associated X protein Mus musculus 240-243 22233278-4 2012 The reaction of HL1 with CuCl(2) gives a mononuclear [Cu(II)(HL1)(2)Cl(2)] (1) complex for which the crystal structure shows that HL1 is preserved. cupric chloride 25-32 intelectin 1 Homo sapiens 16-19 22233278-4 2012 The reaction of HL1 with CuCl(2) gives a mononuclear [Cu(II)(HL1)(2)Cl(2)] (1) complex for which the crystal structure shows that HL1 is preserved. cupric chloride 25-32 intelectin 1 Homo sapiens 61-64 22233278-4 2012 The reaction of HL1 with CuCl(2) gives a mononuclear [Cu(II)(HL1)(2)Cl(2)] (1) complex for which the crystal structure shows that HL1 is preserved. cupric chloride 25-32 intelectin 1 Homo sapiens 61-64 23028994-7 2012 Virulence of the thioredoxin 1 mutant was restored by trans-complementation with redox-active variants of thioredoxin 1 or, surprisingly, by exposing the thioredoxin 1 mutant to sublethal concentrations of the disulphide catalyst copper chloride prior to infection. cupric chloride 230-245 Thioredoxin-1 Caenorhabditis elegans 17-30 22183913-2 2012 Positive ion electrospray mass spectra of aqueous solutions of CuCl(2) and uracil show that the [Cu(Ura-H)(Ura)](+) ion is the most abundant ion even at low concentrations of uracil. cupric chloride 63-70 urate (hydroxyiso-) hydrolase, pseudogene Homo sapiens 101-106 20970483-4 2011 We additionally investigated the binding kinetics of two recombinant human antibodies with different specificities recognizing epitopes of apoB-100 in surface-bound native and CuCl2-oxidized LDL (oxLDL). cupric chloride 176-181 apolipoprotein B Homo sapiens 139-147 21455704-4 2011 Further investigation indicated that the membrane potential determined by rhodamine 123 release decreased after CuCl(2) exposure at 30 and 50 muM. cupric chloride 112-119 latexin Homo sapiens 142-145 20945374-7 2011 We analyzed the 2 h-acute toxicity of CuCl(2) in terms of actin depolymerization and metallothionein 2A (MT2A) and heat shock protein 70 (HSPA1A) genes induction. cupric chloride 38-45 metallothionein 2A Homo sapiens 85-103 20945374-7 2011 We analyzed the 2 h-acute toxicity of CuCl(2) in terms of actin depolymerization and metallothionein 2A (MT2A) and heat shock protein 70 (HSPA1A) genes induction. cupric chloride 38-45 metallothionein 2A Homo sapiens 105-109 20945374-7 2011 We analyzed the 2 h-acute toxicity of CuCl(2) in terms of actin depolymerization and metallothionein 2A (MT2A) and heat shock protein 70 (HSPA1A) genes induction. cupric chloride 38-45 heat shock protein family A (Hsp70) member 1A Homo sapiens 138-144 21318477-2 2011 After application of CuCl(2) (30 muM) the specific cellular copper content increased from initial 1.5 +- 0.2 nmol/mg to a steady state level of 7.9 +- 0.9 nmol/mg within about 12 h. The copper accumulation was accompanied by a significant increase in the extracellular lactate concentration. cupric chloride 21-28 latexin Homo sapiens 33-36 19143551-5 2009 In the presence of CuCl2 in the subphase, Cu2+ ions coordinate to the headgroups of OA and EDA in the monolayers; moreover a new peak at 1220 cm(-1) is observed for the EDA monolayer and assigned to the CH2 twisting and wagging modes relevant to the ethylenediamine headgroups. cupric chloride 19-24 ectodysplasin A Homo sapiens 91-94 19924324-5 2009 Using XPS and STM we have investigated the formation of the CuCl(2) like surface species and propose that it derives from the unusual reactivity of transient copper adatoms released from the p(2 x 1)O by the exothermic formation of water. cupric chloride 60-67 sulfotransferase family 1A member 3 Homo sapiens 14-17 19143551-5 2009 In the presence of CuCl2 in the subphase, Cu2+ ions coordinate to the headgroups of OA and EDA in the monolayers; moreover a new peak at 1220 cm(-1) is observed for the EDA monolayer and assigned to the CH2 twisting and wagging modes relevant to the ethylenediamine headgroups. cupric chloride 19-24 ectodysplasin A Homo sapiens 169-172 18782764-6 2008 Selection for resistance to elevated CuCl2 concentrations led to the isolation of FkpA-DsbA mutants containing a single amino acid substitution that changed the active site of the DsbA domain from CPHC into CPYC, increasing the similarity to the DsbC active site (CGYC). cupric chloride 37-42 putative protein DsbC Escherichia coli 246-250 19041202-7 2009 The results have revealed that Fry"s reagent comprising cupric chloride 90 g, hydrochloric acid 120 mL and water 100mL provided the necessary contrast and was concluded to be the most sensitive. cupric chloride 56-71 FRY microtubule binding protein Homo sapiens 31-34 18077536-9 2008 After intravenous administration of either (64)Cu-TP3939 or (64)CuCl(2) in PC3 xenografts and in transgenic mice, PET/CT images were acquired. cupric chloride 64-71 proprotein convertase subtilisin/kexin type 1 Mus musculus 75-78 18097500-5 2008 In combination, however, homocysteine and CuCl(2) markedly increased O(2)(.-) formation, an effect blocked by SOD, catalase, apocynin, and sildenafil (1 micromol/L) when co-incubated over the same time course. cupric chloride 42-49 catalase Oryctolagus cuniculus 115-123 18834119-1 2008 Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. cupric chloride 104-109 Sp2 transcription factor Homo sapiens 45-48 18834119-1 2008 Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant. cupric chloride 104-109 Sp3 transcription factor Homo sapiens 53-56 18664522-4 2008 The near-UV CD spectra showed a marked change of PCaP1 in CuCl(2) solution. cupric chloride 58-65 plasma-membrane associated cation-binding protein 1 Arabidopsis thaliana 49-54 18664522-9 2008 The PCaP1 solution was titrated with CuCl(2) and the change in the fluorescence spectrum was monitored to characterize Cu(2+)-binding properties. cupric chloride 37-44 plasma-membrane associated cation-binding protein 1 Arabidopsis thaliana 4-9 18077536-15 2008 Binding of (64)CuCl(2) to PC3 was nonspecific. cupric chloride 15-22 proprotein convertase subtilisin/kexin type 1 Mus musculus 26-29 17927914-9 2007 The results of expression analysis showed that GhACS1 displayed its transient expression nature after wounding, abscisic acid (ABA), and CuCl(2) treatments. cupric chloride 137-144 1-aminocyclopropane-1-carboxylate synthase-like Gossypium hirsutum 47-53 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. cupric chloride 147-166 superoxide dismutase 1 Homo sapiens 94-97 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. cupric chloride 147-166 superoxide dismutase 1 Homo sapiens 202-205 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. cupric chloride 147-166 superoxide dismutase 1 Homo sapiens 202-205 18386505-1 2008 A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide. cupric chloride 147-166 superoxide dismutase 1 Homo sapiens 202-205 17617060-11 2007 Expression of hCTR1 resulted in strong activation of the reporter, with maximal induction at 1 muM CuCl2, consistent with the K(m) of hCTR1. cupric chloride 99-104 solute carrier family 31 member 1 Homo sapiens 14-19 17617060-12 2007 Interestingly, expression of hCTR2 significantly induced MRE-luciferase reporter activation in a copper-dependent manner at 40 and 100 microM CuCl2. cupric chloride 142-147 solute carrier family 31 member 2 Homo sapiens 29-34 16961344-0 2006 Antiferromagnetic interaction achieved by a 3-D supramolecular CuII complex with pyrazino-fused TTF as the ligand, [CuCl2(BP-TTF)]. cupric chloride 116-121 ras homolog family member H Homo sapiens 96-99 17563785-2 2007 Surprisingly, the nature of the copper precursor is important in the synthesis of 1, with the reaction between Cu(NO3)2.3H2O, HL(1) and NEt3 giving [Cu6(micro(3)-OMe)4(micro-OMe)2(L(1))6] 2 instead of the anticipated 1, which was obtained with CuCl2.2H2O under the same conditions. cupric chloride 244-254 tetraspanin 2 Homo sapiens 136-140 16961344-0 2006 Antiferromagnetic interaction achieved by a 3-D supramolecular CuII complex with pyrazino-fused TTF as the ligand, [CuCl2(BP-TTF)]. cupric chloride 116-121 ras homolog family member H Homo sapiens 125-128 16961344-1 2006 The diffusion reaction of TBA2Cu(II)Cl4 (TBA = tetrabutylammonium) and a N-containing organic donor, BP-TTF [=bis(pyrazino)tetrathiafulvalene], yielded a 3-D supramolecular Cu complex, [CuCl2(BP-TTF)] (1). cupric chloride 186-191 ras homolog family member H Homo sapiens 104-107 16220354-1 2005 PURPOSE: This study was conducted to assess the positron-emitting copper (II)-64 chloride ((64)CuCl(2)) as a probe for imaging mouse extrahepatic hepatoma expressing mouse copper transporter 1 (mCtr1) with positron emission tomography (PET). cupric chloride 95-102 solute carrier family 31, member 1 Mus musculus 172-192 16445893-2 2006 The decrease of eta of the HA solution, indicating degradation of the biopolymer, was induced by a system containing H2O2 alone or H2O2 plus CuCl2. cupric chloride 141-146 endothelin receptor type A Homo sapiens 16-19 16436375-5 2006 The phenotype associated with the reactive, altered state could be replicated by exposing oocytes expressing T338C CFTR to CuCl2, but not by glutathionylation or nitrosylation of the thiol or by oxidation with hydrogen peroxide. cupric chloride 123-128 CF transmembrane conductance regulator Homo sapiens 115-119 16471974-2 2006 The reactions between CuCl2, Cu(OAc)2, and CuSO4 and the two bipyridylurea ligands L1 and L2 [L1 = 1,3-bis(pyridin-4-ylmethyl)urea; L2 = 1,3-bis(pyridin-3-ylmethyl)urea; see Scheme 1 in paper] have been carried out and the crystal structure of five of the resulting metal-organic assemblies determined. cupric chloride 22-27 L1 cell adhesion molecule Homo sapiens 83-92 16471974-4 2006 Particularly interesting, because of their potential as nanoporous materials, are the assemblies obtained from the reaction between each of the two ligands (L1 and L2) and CuCl2, which yield noninterpenetrating 2D metal-organic layers made of squares of ca. cupric chloride 172-177 L1 cell adhesion molecule Homo sapiens 157-166 16615933-2 2006 The oxidative inactivation of ALR2 induced by CuCl2 at the stoichiometric Cu2+/ALR2 ratio of 2/1 [I. Cecconi, M. Moroni, P.G. cupric chloride 46-51 lens aldose reductase pseudogene Bos taurus 30-34 16615933-2 2006 The oxidative inactivation of ALR2 induced by CuCl2 at the stoichiometric Cu2+/ALR2 ratio of 2/1 [I. Cecconi, M. Moroni, P.G. cupric chloride 46-51 lens aldose reductase pseudogene Bos taurus 79-83 16220354-1 2005 PURPOSE: This study was conducted to assess the positron-emitting copper (II)-64 chloride ((64)CuCl(2)) as a probe for imaging mouse extrahepatic hepatoma expressing mouse copper transporter 1 (mCtr1) with positron emission tomography (PET). cupric chloride 95-102 solute carrier family 31, member 1 Mus musculus 194-199 16220354-7 2005 CONCLUSIONS: The extrahepatic mouse hepatoma grafts may be visualized by Cu-64 PET, taking advantage of the (64)CuCl(2) uptake mediated by the functional endogenous mCtr1. cupric chloride 112-119 solute carrier family 31, member 1 Mus musculus 165-170 16075120-4 2005 In contrast, reaction of [Pt2(mu-S)2(PPh3)4] with CuCl2 and NH3 in methanol gave the intensely blue methoxy-bridged dicopper complex [{Pt(2)(mu-S)2(PPh3)4Cu(OMe)}2]2+, isolated as its hexafluorophosphate salt. cupric chloride 50-55 caveolin 1 Homo sapiens 37-41 16075120-4 2005 In contrast, reaction of [Pt2(mu-S)2(PPh3)4] with CuCl2 and NH3 in methanol gave the intensely blue methoxy-bridged dicopper complex [{Pt(2)(mu-S)2(PPh3)4Cu(OMe)}2]2+, isolated as its hexafluorophosphate salt. cupric chloride 50-55 caveolin 1 Homo sapiens 148-152 15953645-10 2005 Antiproliferative activities of ([CuCl2(L1)2]) and [CuCl2(H2L2)]Cl, where HL2 is the 5-thioxo analog of L1, against human tumor cell lines HT1080 and HT29 as well as normal human fibroblasts (HF) are presented along with the antiproliferative activities of L1, CuCl2, and cisplatin. cupric chloride 52-57 asialoglycoprotein receptor 2 Homo sapiens 74-77 15812313-4 2005 Motoneuron-neuroblastoma hybrid (VSC 4.1) cells expressing mutant SOD1, when treated with copper chloride, showed reduced viability and increased levels of endogenous peroxides. cupric chloride 90-105 superoxide dismutase 1 Homo sapiens 66-70 15960548-0 2005 Efficient and reusable PdCl2(MeCN)2/CuCl2/PEG-400 system for cyclization of alkenyl beta-keto esters and amides. cupric chloride 36-41 phosducin like 2 Homo sapiens 23-28 15741220-4 2005 Here we show that copper (CuCl(2)) stabilizes nuclear HIF-1alpha under normoxic conditions, resulting in hypoxia-response element (HRE)-dependent reporter gene expression. cupric chloride 26-33 hypoxia inducible factor 1, alpha subunit Mus musculus 54-64 12940749-8 2003 Stern-Volmer plots of syn-2 in the presence of CuCl(2) showed a sigmoidal quenching curve indicating cooperative recognition, whereas a linear response was observed with CuCl and ZnCl(2). cupric chloride 47-54 synapsin II Homo sapiens 22-27 15721899-5 2005 Copper chloride on the activated carbon in a range of 3-20 wt% Cu content was present mostly in the amorphous form of CuCl(2), according to the results of the solubility, XRD and TGA tests. cupric chloride 0-15 T-box transcription factor 1 Homo sapiens 179-182 15173313-0 2004 p53-dependent apoptotic mechanism of a new designer bimetallic compound tri-phenyl tin benzimidazolethiol copper chloride (TPT-CuCl2): in vivo studies in Wistar rats as well as in vitro studies in human cervical cancer cells. cupric chloride 106-121 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 0-3 15104205-5 2004 SeP delayed the CuCl2- and AAPH-induced LDL oxidation significantly and more efficiently than bovine serum albumin used as control. cupric chloride 16-21 selenoprotein P Homo sapiens 0-3 15104205-7 2004 The protection of LDL against CuCl2- and AAPH-induced oxidation provides evidence for the antioxidant capacity of SeP. cupric chloride 30-35 selenoprotein P Homo sapiens 114-117 12865660-4 2003 Increased IL-8 in the culture medium of human umbilical vein (HUVEC), lung microvascular, and iliac artery endothelial cells was observed 24 h after the addition of 10 to 50 microM CuCl2 (cupric ions). cupric chloride 181-186 C-X-C motif chemokine ligand 8 Homo sapiens 10-14 12865660-6 2003 HUVEC IL-8 mRNA increased 3 h after CuCl2 stimulation and remained elevated after 24 h, implying sustained transcriptional activation. cupric chloride 36-41 C-X-C motif chemokine ligand 8 Homo sapiens 6-10 12526661-1 2003 Reaction of 5,5-dimethyl-8-nonene-2,4-dione catalyzed by PdCl2(CH3CN)2 (5 mol %) in the presence of CuCl2 (2.5 equiv) at room temperature for 3 h formed 2-acetyl-3,6,6-trimethyl-2-cyclohexenone in 96% isolated yield. cupric chloride 100-105 phosducin like 2 Homo sapiens 57-62 12067251-8 2002 Treatment of p53 cDNA with micromolar concentrations of (+/-)-anti-7,8-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene, (anti-BPDE, an ultimate carcinogen) or sub-micromolar concentrations of BP-7,8-dione in the presence of redox-cycling conditions (NADPH and CuCl(2)) also caused p53 mutations in a dose-dependent manner. cupric chloride 278-285 tumor protein p53 Homo sapiens 13-16 11370844-6 2001 The used cytosol fraction contained 1.37 mM total Cu and 5 mM DTNB titrable-SH groups has a potential to reduce 2 mM CuCl2. cupric chloride 117-122 dystrobrevin, beta Rattus norvegicus 62-66 11456415-4 2001 Fluorescence was also detected in Drosophila S2 tissue culture cells after induction of metallothionein synthesis by addition of CuCl2 to the growth medium. cupric chloride 129-134 Metallothionein D Drosophila melanogaster 88-103 11931660-5 2002 Our data demonstrate that the COX deficiency observed in fibroblasts, myoblasts and myotubes from patients with SCO2 mutations can be restored to almost normal levels by the addition of CuCl(2) to the growth medium. cupric chloride 186-193 cytochrome c oxidase subunit 8A Homo sapiens 30-33 11931660-5 2002 Our data demonstrate that the COX deficiency observed in fibroblasts, myoblasts and myotubes from patients with SCO2 mutations can be restored to almost normal levels by the addition of CuCl(2) to the growth medium. cupric chloride 186-193 synthesis of cytochrome C oxidase 2 Homo sapiens 112-116 11880116-0 2002 Effect of CuCl2, NaCl and EDTA on the enzyme alpha-L-iduronidase in the plasma of normal individuals and heterozygotes for MPS I. cupric chloride 10-15 alpha-L-iduronidase Homo sapiens 45-64 11880116-3 2002 METHODS: We evaluated the effect of copper chloride, EDTA and sodium chloride on the activity of the enzyme alpha-L-iduronidase in the plasma of normal individuals and of MPS I heterozygotes and observed the type of inhibition caused, the Ki, the apparent Km and the apparent Vmax for each inhibitor. cupric chloride 36-51 alpha-L-iduronidase Homo sapiens 108-127 11880116-6 2002 CONCLUSIONS: We detected significant differences capable of differentiating MPS I heterozygotes from normal individuals by simply adding sodium chloride, EDTA or copper chloride to the incubation medium at the time of IDUA activity determination, with a potential use in carrier detection protocols. cupric chloride 162-177 alpha-L-iduronidase Homo sapiens 218-222 11506017-1 2001 Experimentally, CCl4 was effectively mineralized by CuO to yield stable inorganic species of CO2 and CuCl2 (CCl4 + 2CuO --> 2CuCl2 + CO2). cupric chloride 101-106 C-C motif chemokine ligand 4 Homo sapiens 16-20 11506017-1 2001 Experimentally, CCl4 was effectively mineralized by CuO to yield stable inorganic species of CO2 and CuCl2 (CCl4 + 2CuO --> 2CuCl2 + CO2). cupric chloride 101-106 C-C motif chemokine ligand 4 Homo sapiens 108-112 11506017-3 2001 Using X-ray-absorption near edge structure (XANES) and X-ray photoelectron spectroscopies, we found that most CuCl2 was encapsulated in the CCl4-mineralized product solid (mineralization at 513 K for 30 min). cupric chloride 110-115 C-C motif chemokine ligand 4 Homo sapiens 140-144 11506017-6 2001 Bond distances of Cu-O and Cu-Cl in the CCl4-mineralized product solid were 1.93-1.94 and 2.10-2.12 , respectively, which were greater than those of normal CuO and CuCl2 by 0.03-0.07 A. cupric chloride 164-169 C-C motif chemokine ligand 4 Homo sapiens 40-44 11314951-5 2001 The lipoxygenase inhibitor ibuprofen suppressed the accumulation of HDMBOA-Glc induced by CuCl2 treatment, and the reduced accumulation of HDMBOA-Glc was recovered by addition of JA. cupric chloride 90-95 linoleate 9S-lipoxygenase4 Zea mays 4-16 11342034-7 2001 Absorption spectra of histatin 5 at increasing copper chloride concentrations resulted in higher absorbance in the 230-280 nm wavelength range and this spectral change was saturated at a peptide:metal molar ratio of approx. cupric chloride 47-62 histatin 3 Homo sapiens 22-32 11232828-2 2000 The reaction of copper(II) chloride with H2L1 leads not to a syn-anti carboxylate-bridged compound but to the chloride-bridged dinuclear complex [Cu(HL1)(mu-Cl)]2 (6). cupric chloride 16-35 dynein axonemal heavy chain 5 Homo sapiens 149-152 10600810-5 1999 Treatment with CuCl(2) produced a concentration-dependent reduction in the staining of F actin but not of the junctional proteins zonula occludens-1, occludin, and E-cadherin and produced ultrastructural alterations to microvilli and tight junctions that were not observed after treatment with up to 200 microM Cu(His)(2) for 3 h. Overall, these data point to an intracellular effect of copper on tight junctions, mediated by perturbations of the F actin cytoskeleton. cupric chloride 15-22 occludin Homo sapiens 150-158 10600810-5 1999 Treatment with CuCl(2) produced a concentration-dependent reduction in the staining of F actin but not of the junctional proteins zonula occludens-1, occludin, and E-cadherin and produced ultrastructural alterations to microvilli and tight junctions that were not observed after treatment with up to 200 microM Cu(His)(2) for 3 h. Overall, these data point to an intracellular effect of copper on tight junctions, mediated by perturbations of the F actin cytoskeleton. cupric chloride 15-22 cadherin 1 Homo sapiens 164-174 11124219-9 2001 The taste threshold in tap water was 2.6 mg/l Cu for both copper sulfate and copper chloride. cupric chloride 77-92 nuclear RNA export factor 1 Homo sapiens 23-26