PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3335323-5	1988	It was not until shortly after intravenous administration of a cupric chloride solution during a 5-day period, at a total dose of 10 mg, that serum copper and ceruloplasmin levels increased and the anemia, leukopenia, and neutropenia resolved.	cupric chloride	63-78	ceruloplasmin	Homo sapiens	159-172
2715044-2	1989	Hepatic copper accumulation following intraperitoneal injection of cupric chloride resulted in a dose-dependent reduction in the density of catalase-containing peroxisomes.	cupric chloride	67-82	catalase	Rattus norvegicus	140-148
9946881-0	1988	Linear spin-(1/2 magnetic chains: Susceptibilities, correlation functions, and applications to (C6H11NH3)CuBr3 and deuterated CuCl2	cupric chloride	126-131	spindlin 1	Homo sapiens	7-16
2620798-5	1989	Binding of Ni(II) to CAM in the presence of Ca(II) is inhibited slightly by added MnCl2 (50 microM) and very strongly by CuCl2 and ZnCl2 (10 microM).	cupric chloride	121-126	calmodulin 1	Homo sapiens	21-24
2620798-5	1989	Binding of Ni(II) to CAM in the presence of Ca(II) is inhibited slightly by added MnCl2 (50 microM) and very strongly by CuCl2 and ZnCl2 (10 microM).	cupric chloride	121-126	carbonic anhydrase 2	Homo sapiens	44-50
2866488-1	1985	A progressive reduction in the size of rat metallothionein-1 mRNA following induction by copper chloride or dexamethasone was demonstrated on RNA blots, and was shown to be due to shortening of the poly(A)-tail.	cupric chloride	89-104	metallothionein 1	Rattus norvegicus	43-60
24458697-1	1984	Purified maize leaf phosphoenolpyruvate carboxylase (EC 4.1.1.31) was completely inactivated by several thiol-modifying reagents, including, CuCl2, CdCl2 and N-ethylmaleimide.	cupric chloride	141-146	MLO-like protein 4	Zea mays	20-51
24458697-2	1984	The inactivation by CuCl2 could be reversed by dithiothreitol, suggesting the involvement of vicinal dithiols in the inactivation process.Complete inactivation of phosphoenolpyruvate carboxylase was correlated with the incorporation of two mol ((3)H)N-ethylmaleimide per 100-kilodalton subunit.	cupric chloride	20-25	MLO-like protein 4	Zea mays	163-194
6328143-3	1984	Human erythrocyte CNP activity was reduced 75 percent by the organomercurial p-chloromercuriphenyl sulfonate (1 X 10(-4) M), 46 percent by thimerosal (1 X 10(-4) M) and 35 percent by cupric chloride (1 X 10(-3) M).	cupric chloride	183-198	2',3'-cyclic nucleotide 3' phosphodiesterase	Homo sapiens	18-21
6694001-6	1984	Injection of CuCl2 into -Cu mice resulted in significant increases in body and brain weight, elevations in serum copper and ceruloplasmin activities and hemoglobin levels.	cupric chloride	13-18	ceruloplasmin	Mus musculus	124-137
7213864-4	1980	The reaction results in formation of RO and RO2 radicals destroying cytochrome P-450 CuCl2 (0,001 M) also destroys cytochrome P-450 in the absence of cumene hydroperoxide; the destruction process is characterized by two phases with different rate constants.	cupric chloride	85-90	cytochrome P-450	Oryctolagus cuniculus	68-84
6263423-1	1981	The purified oligodendrocyte enzyme 2",3"-cyclic nucleotide 3"-phosphodiesterase (CNP) obtained from bovine, human and guinea pig brain was inhibited by theophylline, caffeine, cupric chloride and organomercurials using a spectrophotometric assay and 1 mM 2",3"- cyclic cytidylate as the substrate.	cupric chloride	177-192	2',3'-cyclic nucleotide 3' phosphodiesterase	Bos taurus	36-80
6263423-1	1981	The purified oligodendrocyte enzyme 2",3"-cyclic nucleotide 3"-phosphodiesterase (CNP) obtained from bovine, human and guinea pig brain was inhibited by theophylline, caffeine, cupric chloride and organomercurials using a spectrophotometric assay and 1 mM 2",3"- cyclic cytidylate as the substrate.	cupric chloride	177-192	2',3'-cyclic nucleotide 3' phosphodiesterase	Bos taurus	82-85
7213864-4	1980	The reaction results in formation of RO and RO2 radicals destroying cytochrome P-450 CuCl2 (0,001 M) also destroys cytochrome P-450 in the absence of cumene hydroperoxide; the destruction process is characterized by two phases with different rate constants.	cupric chloride	85-90	cytochrome P-450	Oryctolagus cuniculus	115-131
33930976-8	2021	The kinetic reaction equation of the CuCl2 volatilization process can be described by Power Low, G(alpha) = alpha1/15.	cupric chloride	37-42	BCL2 related protein A1	Homo sapiens	108-117
17743969-2	1965	At 5 x 10(-7)M ferric chloride or 10(-8)M cupric chloride, breakdown of hiydrogen peroxide was significant at -11 degrees and -18 degrees but negligible at +1 degrees C. Ascorbic acid oxidation was faster in ice both with or without added metalion.	cupric chloride	42-57	carboxylesterase 2	Homo sapiens	208-211
34051663-9	2021	Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62.	cupric chloride	36-41	microtubule-associated protein 1 light chain 3 alpha	Rattus norvegicus	123-136
34051663-9	2021	Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62.	cupric chloride	36-41	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	164-167
34051663-9	2021	Furthermore, nano-Cu, micro-Cu, and CuCl2.2 H2O upregulated the expression of the autophagy-related proteins, Beclin-1 and LC3 II/ LC3 I, and downregulated that of p62.	cupric chloride	36-41	beclin 1	Rattus norvegicus	110-118
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	cupric chloride	33-38	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	cupric chloride	33-38	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	cupric chloride	33-38	mechanistic target of rapamycin kinase	Rattus norvegicus	108-112
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	cupric chloride	33-38	mechanistic target of rapamycin kinase	Rattus norvegicus	113-117
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	cupric chloride	33-38	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	172-176
34051663-10	2021	Moreover, nano-Cu, micro-Cu, and CuCl2.2 H2O downregulated the protein expression of PI3K, p-AKT/AKT, and p-mTOR/mTOR in rat placentas, whereas the protein expression of p-AMPK/AMPK was upregulated.	cupric chloride	33-38	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	177-181
31999107-1	2020	A new spin-1/2 frustrated antiferromagnet, Cu9O2(VO4)4Cl2, was synthesized via chemical vapor transport method that emulates mineral formation in volcanic fumaroles.	cupric chloride	43-57	spindlin 1	Homo sapiens	6-14
33571669-0	2021	The role of TGF-beta1/Smad3 signaling pathway and oxidative stress in the inhibition of osteoblast mineralization by copper chloride.	cupric chloride	117-132	transforming growth factor beta 1	Homo sapiens	12-21
33571669-0	2021	The role of TGF-beta1/Smad3 signaling pathway and oxidative stress in the inhibition of osteoblast mineralization by copper chloride.	cupric chloride	117-132	SMAD family member 3	Homo sapiens	22-27
33571669-2	2021	It indicates that the inactivated TGF-beta1/Smad3 pathway leads to osteoblast impairment by CuCl2.	cupric chloride	92-97	transforming growth factor beta 1	Homo sapiens	34-43
33571669-2	2021	It indicates that the inactivated TGF-beta1/Smad3 pathway leads to osteoblast impairment by CuCl2.	cupric chloride	92-97	SMAD family member 3	Homo sapiens	44-49
32432590-0	2020	Li2(Se2O5)(H2O)1.5 CuCl2, a salt-inclusion diselenite structurally based on tetranuclear Li4 complexes.	cupric chloride	19-24	ATP binding cassette subfamily A member 12	Homo sapiens	0-3
32432590-0	2020	Li2(Se2O5)(H2O)1.5 CuCl2, a salt-inclusion diselenite structurally based on tetranuclear Li4 complexes.	cupric chloride	19-24	lipase family member N	Homo sapiens	89-92
33918312-9	2021	CuCl2 stabilized HIF-1alpha expression under normoxia in OECM-1 cells, and complex with DSF enhanced that effect.	cupric chloride	0-5	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-27
33461096-5	2021	HMGB1 dimerization was positively modulated by CuCl2 and H2O2.	cupric chloride	47-52	high mobility group box 1	Homo sapiens	0-5
33461096-7	2021	Treatment of HEK293T cells with CuCl2 and H2O2 enhanced the oxidative self-dimerization of HMGB1, whereas this dimerization was inhibited in mutant HMGB1C106A cells.	cupric chloride	32-37	high mobility group box 1	Homo sapiens	91-96
33461096-7	2021	Treatment of HEK293T cells with CuCl2 and H2O2 enhanced the oxidative self-dimerization of HMGB1, whereas this dimerization was inhibited in mutant HMGB1C106A cells.	cupric chloride	32-37	high mobility group box 1	Homo sapiens	148-153
33462188-9	2021	Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta.	cupric chloride	94-99	NLR family, pyrin domain containing 3	Mus musculus	31-36
33462188-9	2021	Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta.	cupric chloride	94-99	caspase 1	Mus musculus	148-157
33462188-9	2021	Furthermore, the activation of NLRP3 inflammasome was noted in primary microglia treated with CuCl2, accompanied by the increased levels of cleaved caspase-1, ASC, and interleukin-1beta.	cupric chloride	94-99	interleukin 1 beta	Mus musculus	168-185
33434428-2	2021	The Cu-1/2 metalated peptides were synthesized by reacting 1/2 with CuCl2 and were characterized by LC-ESI-MS and HR-ESI-MS. Cu-1/2 exhibited high GRPR-binding affinities with IC50 values <3 nM, as measured in a competition assay using the GRPR-expressing human PC-3 prostate cancer cell line and [125I]I-Tyr4-BBN as the competing ligand.	cupric chloride	68-73	immunoglobulin kappa variable 1-35	Mus musculus	4-10
33434428-2	2021	The Cu-1/2 metalated peptides were synthesized by reacting 1/2 with CuCl2 and were characterized by LC-ESI-MS and HR-ESI-MS. Cu-1/2 exhibited high GRPR-binding affinities with IC50 values <3 nM, as measured in a competition assay using the GRPR-expressing human PC-3 prostate cancer cell line and [125I]I-Tyr4-BBN as the competing ligand.	cupric chloride	68-73	immunoglobulin kappa variable 1-35	Mus musculus	125-131
33379315-2	2020	Herein, the reaction of triarylantimony difluorides with benzofurans under aerobic conditions in 1,2-DCE, using 5 mol% Pd (OAc)2 and 2 eq. of CuCl2 at 80  C, produced a variety of 2-arylbenzofurans in moderate-to-high yields.	cupric chloride	142-147	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	119-134
33084689-1	2020	Reduction of copper(ii) chloride using sodium ascorbate in the presence of pure sodium 5-nitro-tetrazolate (NaNT) forms copper(i) 5-nitrotetrazolate - a known initiatory explosive (DBX-1) - and the novel mixed-ligand copper(i) chloride 5-nitrotetrazolate coordination polymer Cu3Cl(N4C-NO2)2, as well as mixtures of both.	cupric chloride	13-32	developing brain homeobox 1	Homo sapiens	181-186
32926024-6	2020	Accordingly, the levels of ER stress-related factors (especially, CHOP and GADD34) and of phosphorylated JNK increased upon CuCl2 and ZnCl2 co-treatment, whereas pre-treatment with seleno-l-methionine significantly suppressed these upregulations.	cupric chloride	124-129	DNA-damage inducible transcript 3	Mus musculus	66-70
32926024-6	2020	Accordingly, the levels of ER stress-related factors (especially, CHOP and GADD34) and of phosphorylated JNK increased upon CuCl2 and ZnCl2 co-treatment, whereas pre-treatment with seleno-l-methionine significantly suppressed these upregulations.	cupric chloride	124-129	protein phosphatase 1, regulatory subunit 15A	Mus musculus	75-81
32926024-6	2020	Accordingly, the levels of ER stress-related factors (especially, CHOP and GADD34) and of phosphorylated JNK increased upon CuCl2 and ZnCl2 co-treatment, whereas pre-treatment with seleno-l-methionine significantly suppressed these upregulations.	cupric chloride	124-129	mitogen-activated protein kinase 8	Mus musculus	105-108
32745495-5	2020	Incubation of RBC with CuCl2 increased protein oxidation, lipid peroxidation, methemoglobin formation and lowered glutathione content.	cupric chloride	23-28	hemoglobin subunit gamma 2	Homo sapiens	78-91
32375703-6	2020	RESULTS: In mice, the stimulating effect of 100 nM CuCl2 is absent in the retinae from Cav2.3-deficient mice, but prominent in Cav2.3-competent mice.	cupric chloride	51-56	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	87-93
32375703-6	2020	RESULTS: In mice, the stimulating effect of 100 nM CuCl2 is absent in the retinae from Cav2.3-deficient mice, but prominent in Cav2.3-competent mice.	cupric chloride	51-56	calcium channel, voltage-dependent, R type, alpha 1E subunit	Mus musculus	127-133
31582212-0	2019	Anamorsin attenuates cupric chloride-induced dopaminergic neuronal cell death.	cupric chloride	21-36	cytokine induced apoptosis inhibitor 1	Mus musculus	0-9
31582212-3	2019	In this study, we showed that overexpression of anamorsin protected MN9D dopaminergic neuronal cells from cupric chloride-induced death.	cupric chloride	106-121	cytokine induced apoptosis inhibitor 1	Mus musculus	48-57
31702204-1	2019	We report an experimental and theoretical study of the low-temperature specific heat C and magnetic susceptibility chi of the layered anisotropic triangular-lattice spin-1/2 Heisenberg antiferromagnets Cs_{2}CuCl_{4-x}Br_{x} with x=0, 1, 2, and 4.	cupric chloride	208-212	spindlin 1	Homo sapiens	165-171
30768131-7	2019	Accordingly, we found that phosphorylated (ie, active) forms of SAPK/JNK (p46 and p54) are increased by CuCl2 and ZnCl2 co-treatment in hypothalamic neuronal mouse cells (GT1-7 cells).	cupric chloride	104-109	mitogen-activated protein kinase 8	Mus musculus	69-72
30768131-7	2019	Accordingly, we found that phosphorylated (ie, active) forms of SAPK/JNK (p46 and p54) are increased by CuCl2 and ZnCl2 co-treatment in hypothalamic neuronal mouse cells (GT1-7 cells).	cupric chloride	104-109	interferon-induced protein with tetratricopeptide repeats 2	Mus musculus	82-85
30768131-8	2019	Downstream factors of SAPK/JNK, phospho-c-Jun, and phospho-activating transcription factor 2 are also induced by CuCl2 and ZnCl2 co-treatment.	cupric chloride	113-118	mitogen-activated protein kinase 8	Mus musculus	27-30
30768131-8	2019	Downstream factors of SAPK/JNK, phospho-c-Jun, and phospho-activating transcription factor 2 are also induced by CuCl2 and ZnCl2 co-treatment.	cupric chloride	113-118	jun proto-oncogene	Mus musculus	40-45
30768131-9	2019	Moreover, an inhibitor of the SAPK/JNK signaling pathway, SP600125, significantly suppressed neuronal cell death and activation of the SAPK/JNK signaling pathway induced by CuCl2 and ZnCl2 cotreatment.	cupric chloride	173-178	mitogen-activated protein kinase 8	Mus musculus	35-38
30768131-9	2019	Moreover, an inhibitor of the SAPK/JNK signaling pathway, SP600125, significantly suppressed neuronal cell death and activation of the SAPK/JNK signaling pathway induced by CuCl2 and ZnCl2 cotreatment.	cupric chloride	173-178	mitogen-activated protein kinase 8	Mus musculus	140-143
30768131-11	2019	On the basis of these results, our findings suggest that activation of ZnCl2-dependent SAPK/JNK signaling pathway is important in neuronal cell death, and CuCl2-induced oxidative stress triggers the activation of this pathway.	cupric chloride	155-160	mitogen-activated protein kinase 8	Mus musculus	92-95
28927334-7	2017	Moreover, CuCl2 dramatically enriched the extracellular matrices with collagen I, collagen III, transforming growth factor-beta1, vascular endothelial growth factor, and basic fibroblast growth factor via hypoxia-inducible factor-1alpha activation.	cupric chloride	10-15	transforming growth factor, beta 1	Mus musculus	70-128
30223654-1	2018	A new approach of finely tuning multinuclear clusters of metal-organic frameworks (MOFs) through symmetry-upgradingly isoreticular transformation was first presented and a bcu-type MOF, {[Cu4(mu4-O)Cl2(IN)4][CuCl2]}  (NJU-Bai35; NJU-Bai for Nanjing University Bai group), with cluster [Cu4(mu4-O)Cl2(COO)4N4] of higher symmetry compared to the pristine MOF, was successfully synthesized.	cupric chloride	208-213	lysine acetyltransferase 8	Homo sapiens	83-86
30223654-1	2018	A new approach of finely tuning multinuclear clusters of metal-organic frameworks (MOFs) through symmetry-upgradingly isoreticular transformation was first presented and a bcu-type MOF, {[Cu4(mu4-O)Cl2(IN)4][CuCl2]}  (NJU-Bai35; NJU-Bai for Nanjing University Bai group), with cluster [Cu4(mu4-O)Cl2(COO)4N4] of higher symmetry compared to the pristine MOF, was successfully synthesized.	cupric chloride	208-213	lysine acetyltransferase 8	Homo sapiens	181-184
30120852-9	2018	Functional analysis of these novel variants in five different cell lines lacking inherent ATP7B expression demonstrated sensitivity to CuCl2 -treatment, experiencing augmented cellular copper retention and decreased copper excretion as well as ceruloplasmin secretion to that of wildtype-ATP7B expressing cells.	cupric chloride	135-140	ATPase copper transporting beta	Homo sapiens	90-95
30120852-9	2018	Functional analysis of these novel variants in five different cell lines lacking inherent ATP7B expression demonstrated sensitivity to CuCl2 -treatment, experiencing augmented cellular copper retention and decreased copper excretion as well as ceruloplasmin secretion to that of wildtype-ATP7B expressing cells.	cupric chloride	135-140	ceruloplasmin	Homo sapiens	244-257
30120852-9	2018	Functional analysis of these novel variants in five different cell lines lacking inherent ATP7B expression demonstrated sensitivity to CuCl2 -treatment, experiencing augmented cellular copper retention and decreased copper excretion as well as ceruloplasmin secretion to that of wildtype-ATP7B expressing cells.	cupric chloride	135-140	ATPase copper transporting beta	Homo sapiens	288-293
31245723-9	2018	Oxidative stress, simulated by the addition of CuCl2, leads to the formation of high molecular weight polymers of beta-amylase similar to those detected in vivo.	cupric chloride	47-52	1,4-alpha-D-glucan maltohydrolase	Hordeum vulgare	114-126
30627687-1	2019	The overall structure of dihydrate cupric chloride (CuCl2 * 2H2O) crystallization patterns in the presence of bovine serum albumin (BSA) in a Petri dish is influenced by dewetting.	cupric chloride	52-64	albumin	Homo sapiens	117-130
30351077-2	2018	The general reaction between CuCl2 2H2O, LnCl3 6H2O, phenoxH, and NEt3 in a 1:2:2:4 molar ratio, in a solvent mixture comprising MeCN and MeOH, afforded brown crystals of a new family of [Cu3LnCl3(phenox)6(MeOH)3] clusters (Ln = Gd (1), Tb (2), Dy (3)) that possess an unprecedented [Cu3Ln(mu-NO)6]3+ "propeller"-like core.	cupric chloride	29-39	tetraspanin 2	Homo sapiens	66-70
30234099-6	2018	Co-incubation of the metallodrugs with CuCl2 (a CTR1 substrate) increased the cytotoxic effects of both the Au(III) complex and cisplatin; while co-incubation with cimetidine (inhibitor of OCT2 and MATE) showed some effect only after 72 h incubation.	cupric chloride	39-44	calcitonin receptor	Homo sapiens	48-52
30234099-6	2018	Co-incubation of the metallodrugs with CuCl2 (a CTR1 substrate) increased the cytotoxic effects of both the Au(III) complex and cisplatin; while co-incubation with cimetidine (inhibitor of OCT2 and MATE) showed some effect only after 72 h incubation.	cupric chloride	39-44	POU class 2 homeobox 2	Homo sapiens	189-193
29229814-3	2017	The SE2 backside reaction is favored as a trigger step for the dehydrogenation of AB by the MCl2 The SE2 reaction is found for 3d-transition-metal chlorides (e.g., FeCl2, CoCl2, NiCl2, CuCl2, and ZnCl2), while PdCl2 leads to the dehydrogenation of AB by a direct B-H sigma-bond activation, similar to most organometallic catalysts.	cupric chloride	185-190	fucosyltransferase 2	Homo sapiens	4-7
29229814-3	2017	The SE2 backside reaction is favored as a trigger step for the dehydrogenation of AB by the MCl2 The SE2 reaction is found for 3d-transition-metal chlorides (e.g., FeCl2, CoCl2, NiCl2, CuCl2, and ZnCl2), while PdCl2 leads to the dehydrogenation of AB by a direct B-H sigma-bond activation, similar to most organometallic catalysts.	cupric chloride	185-190	fucosyltransferase 2	Homo sapiens	101-104
29234903-1	2017	BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells.	cupric chloride	79-96	solute carrier family 31 member 1	Homo sapiens	213-233
29234903-1	2017	BACKGROUND: In recent years, Copper-64 (T1/2 = 12.7 h) in the chemical form of copper dichloride ([64Cu]CuCl2) has been identified as a potential agent for PET imaging and radionuclide therapy targeting the human copper transporter 1, which is overexpressed in a variety of cancer cells.	cupric chloride	104-109	solute carrier family 31 member 1	Homo sapiens	213-233
28130615-6	2017	Furthermore, age-dependent increase of 64Cu radioactivity was detected in the brains of Atp7b -/- knockout mice from the 13th to 21th weeks of age, based on the data derived from a longitudinal [64C]CuCl2-PET/CT study of Atp7b -/- knockout mice with orally administered [64Cu]CuCl2 as a tracer.	cupric chloride	199-204	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	88-93
28130615-6	2017	Furthermore, age-dependent increase of 64Cu radioactivity was detected in the brains of Atp7b -/- knockout mice from the 13th to 21th weeks of age, based on the data derived from a longitudinal [64C]CuCl2-PET/CT study of Atp7b -/- knockout mice with orally administered [64Cu]CuCl2 as a tracer.	cupric chloride	276-281	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	88-93
28130615-0	2017	Age-dependent changes of cerebral copper metabolism in Atp7b -/- knockout mouse model of Wilson"s disease by [64Cu]CuCl2-PET/CT.	cupric chloride	115-120	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	55-60
28130615-4	2017	The objective of this study was to explore the feasibility and use of copper-64 chloride ([64C]CuCl2) as a tracer for noninvasive assessment of age-dependent changes of cerebral copper metabolism in WD using an Atp7b -/- knockout mouse model of WD and positron emission tomography/computed tomography (PET/CT) imaging.	cupric chloride	95-100	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	211-216
28533936-2	2017	[64Cu]PSMA-617 was synthesized by heating PSMA-617 with [64Cu]CuCl2 in buffer solution at 90 C for 5 min.	cupric chloride	62-67	folate hydrolase 1	Homo sapiens	6-10
28130615-5	2017	Continuing from our recent study of biodistribution and radiation dosimetry of [64C]CuCl2 in Atp7b -/- knockout mice, PET quantitative analysis revealed low 64Cu radioactivity in the brains of Atp7b -/- knockout mice at 7th weeks of age, compared with 64Cu radioactivity in the brains of age- and gender-matched wild type C57BL/6 mice, at 24 h (h) post intravenous injection of [64C]CuCl2 as a tracer.	cupric chloride	383-388	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	193-198
28533936-2	2017	[64Cu]PSMA-617 was synthesized by heating PSMA-617 with [64Cu]CuCl2 in buffer solution at 90 C for 5 min.	cupric chloride	62-67	folate hydrolase 1	Homo sapiens	42-46
27484443-2	2016	The reaction of CuCl2, HL 2HCl and triethylamine (NEt3) in a molar ratio of 1 : 1 : 3 in water was found to generate a novel organometallic tetrazole derivative Cu2L2Cl2.	cupric chloride	16-21	tetraspanin 2	Homo sapiens	50-54
28250280-6	2017	MgCl2, NiCl2, ZnCl2, CuCl2 and CaCl2 dose-dependently decreased agonist-induced YO-PRO-1 uptake via both human and mouse P2X7Rs.	cupric chloride	21-26	lamin A/C	Homo sapiens	83-88
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric chloride	98-103	interleukin 1 alpha	Homo sapiens	0-9
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric chloride	98-103	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric chloride	98-103	heat shock protein family A (Hsp70) member 1A	Homo sapiens	20-26
27892491-9	2016	IL-1alpha and IL-8, HSPA1A and FOSL1 were significantly upregulated following 24-h treatment with CuCl2 and Cu(OAc)2 at 58 and 580 muM without concomitant inhibition in cell viability.	cupric chloride	98-103	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	31-36
28338141-3	2017	In contrast, the Cu(ii) and Mn(ii) complexes [CuCl2(L)] and [MnCl2(L)] are highly cytotoxic with EC50 values of 1.25 +- 0.01 muM and 20 +- 1 muM, respectively.	cupric chloride	46-51	latexin	Homo sapiens	125-128
28338141-3	2017	In contrast, the Cu(ii) and Mn(ii) complexes [CuCl2(L)] and [MnCl2(L)] are highly cytotoxic with EC50 values of 1.25 +- 0.01 muM and 20 +- 1 muM, respectively.	cupric chloride	46-51	latexin	Homo sapiens	141-144
25293311-5	2014	Replacing copper(II) acetate by copper(II) chloride in the synthesis leads to compound [Cu(I)Cl(H2-1,3-bdpb)], which crystallizes in the orthorhombic crystal system, within the space group Pnma (no.	cupric chloride	32-51	A-kinase anchoring protein 5	Homo sapiens	96-100
26247622-1	2015	Cu-mediated C-2 chlorination of indoles was accomplished with copper(ii) chloride through the use of a directing pyrimidyl protection group.	cupric chloride	62-81	complement C2	Homo sapiens	12-15
26034833-6	2015	(c) The 6-endo product P1 is formed exclusively using a catalytic system consisting of CuCl and DMF, whereas a mixture of 6-endo product P1 and 5-exo product P2 in a ratio of ~1:1 is produced using CuCl2 and DMF as a catalytic system.	cupric chloride	198-203	crystallin gamma F, pseudogene	Homo sapiens	137-145
25756315-1	2015	A mild and efficient methodology involving Pd(PPh3)4-catalyzed intramolecular cyclization of N-alkynyl alkyloxycarbamates with CuCl2 or CuBr2 for the synthesis of 4-halo-oxazolones was developed.	cupric chloride	127-132	caveolin 1	Homo sapiens	46-50
27045752-0	2016	Copper Chloride Catalysis: Do mu4-Oxido Copper Clusters Play a Significant Role?	cupric chloride	0-15	adaptor related protein complex 4 subunit mu 1	Homo sapiens	30-33
27045752-7	2016	It can be clearly demonstrated that mu4-oxido copper clusters of the formula [Cu4OCl6(solvent)4] are the main product from the reactions of CuCl2 2H2O and basic coreagents.	cupric chloride	140-150	adaptor related protein complex 4 subunit mu 1	Homo sapiens	36-39
27045752-8	2016	As a final result of these experiments, it can be stated that mu4-oxido copper clusters most likely play an important role in the mechanism of copper chloride-catalyzed reactions.	cupric chloride	143-158	adaptor related protein complex 4 subunit mu 1	Homo sapiens	62-65
26370442-3	2015	Reaction of H3L with CuCl2 forms a mononuclear copper(ii) [Cu(Cl)(H2L)(H2O)] (H2L-Cu(2+)) complex which is characterized by conventional techniques and quantum chemical calculations.	cupric chloride	21-26	H3 clustered histone 2	Homo sapiens	12-15
26169410-1	2015	The in vitro activity of the aminoglycoside 6"-N-acetyltransferase type Ib [AAC(6")-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 muM.	cupric chloride	105-110	aminoglycoside N(6')-acetyltransferase	Klebsiella pneumoniae	72-74
26169410-1	2015	The in vitro activity of the aminoglycoside 6"-N-acetyltransferase type Ib [AAC(6")-Ib] was inhibited by CuCl2 with a 50% inhibitory concentration (IC50) of 2.8 muM.	cupric chloride	105-110	aminoglycoside N(6')-acetyltransferase	Klebsiella pneumoniae	76-86
26032686-5	2015	We found that extrinsic expressing WT ATP7B reduced CuCl2-induced copper accumulation and enhanced cellular copper tolerance by accelerating copper excretion, which was selectively compromised by R778L and P992L mutations.	cupric chloride	52-57	ATPase copper transporting beta	Homo sapiens	38-43
25689591-2	2015	PdCl2(CH3CN)2 was used as the catalyst and CuCl2 as the oxidant under the balloon pressure of CO.	cupric chloride	43-48	phosducin like 2	Homo sapiens	0-5
25294121-5	2014	Profound stabilities and optimised structures of (001)CuCl and (001)Cl configurations are discussed within the context of the functionality of CuCl2 as the chief chlorination and condensation catalyst of aromatic pollutants under conditions relevant to their formation in thermal systems, i.e. 400-1000 K, a total operating pressure of 1.0 atm and PCl2 = 10(-6)-10(-4) atm (1.0-100.0 ppm).	cupric chloride	143-148	metal response element binding transcription factor 2	Homo sapiens	348-352
24869914-0	2014	Magnetic anisotropy in a spin 1/2 quasi-one-dimensional antiferromagnetic copper(II) complex CuCl2(pdz) with a staggered g-tensor.	cupric chloride	93-98	spindlin 1	Homo sapiens	25-33
25745767-8	2014	In the present study, the influence of 1 nM solutions of GHK, GHK-Cu and CuCl2, on IGF-2-dependent TGF-beta1 secretion in normal human dermal fibroblasts cells was investigated.	cupric chloride	73-78	insulin like growth factor 2	Homo sapiens	83-88
25745767-8	2014	In the present study, the influence of 1 nM solutions of GHK, GHK-Cu and CuCl2, on IGF-2-dependent TGF-beta1 secretion in normal human dermal fibroblasts cells was investigated.	cupric chloride	73-78	transforming growth factor beta 1	Homo sapiens	99-108
25108186-6	2014	The fibrosis of hIAPP was inhibited by CuCl2, CuSO4 and Cu(Gly)2 with a similar degree.	cupric chloride	39-44	islet amyloid polypeptide	Homo sapiens	16-21
25108186-8	2014	Moreover, approximative cytotoxicity-enhancing levels between CuCl2, CuSO4 and Cu(Gly)2 on hIAPP were also observed in INS-1 cells.	cupric chloride	62-67	islet amyloid polypeptide	Homo sapiens	91-96
25273418-1	2014	The cause for the preferred spin orientation in magnetic systems containing spin-1/2 transition-metal ions was explored by studying the origin of the easy-plane anisotropy of the spin-1/2 Cu(2+) ions in CuCl2 2H2O, LiCuVO4, CuCl2, and CuBr2 on the basis of density functional theory and magnetic dipole-dipole energy calculations as well as a perturbation theory treatment of the spin-orbit coupling.	cupric chloride	203-208	spindlin 1	Homo sapiens	76-82
25273418-1	2014	The cause for the preferred spin orientation in magnetic systems containing spin-1/2 transition-metal ions was explored by studying the origin of the easy-plane anisotropy of the spin-1/2 Cu(2+) ions in CuCl2 2H2O, LiCuVO4, CuCl2, and CuBr2 on the basis of density functional theory and magnetic dipole-dipole energy calculations as well as a perturbation theory treatment of the spin-orbit coupling.	cupric chloride	203-208	spindlin 1	Homo sapiens	76-84
25091475-12	2014	CONCLUSION: An increase in (64)Cu uptake induced by the expression of hCTR1 gene was demonstrated in vivo and in vitro, suggesting the potential use of hCTR1 gene as a new imaging reporter gene for PET with (64)CuCl2.	cupric chloride	211-216	solute carrier family 31 member 1	Homo sapiens	70-75
25091475-12	2014	CONCLUSION: An increase in (64)Cu uptake induced by the expression of hCTR1 gene was demonstrated in vivo and in vitro, suggesting the potential use of hCTR1 gene as a new imaging reporter gene for PET with (64)CuCl2.	cupric chloride	211-216	solute carrier family 31 member 1	Homo sapiens	152-157
24639459-12	2014	CONCLUSION: Overall, data indicated that hCtr1 is a promising theranostic target, which can be further developed for metabolic imaging of prostate cancer using (64)CuCl2 PET/CT and personalized cancer therapy targeting copper metabolism.	cupric chloride	164-169	solute carrier family 31 member 1	Homo sapiens	41-46
24901737-6	2014	An inductively coupled plasma optical emission spectrometry (ICP-OES) analysis illustrated that, compared to the wild type seedlings the Sali3-2-transgenic seedlings accumulated more cadmium or copper in the roots but less in the upper ground tissues when the seedlings were exposed to excessive CuCl2 or CdCl2 stress.	cupric chloride	296-301	Sali3-2	Glycine max	137-144
22515166-10	2012	Combined treatment with 100 muM CuCl2 and 200 muM BZF (which are only marginally effective when administered individually) achieved complete rescue of COX activity in SCO2 cells.	cupric chloride	32-37	cytochrome c oxidase subunit 8A	Homo sapiens	151-154
24508213-4	2014	The new bivalent GRPr/PSMA targeting vector was purified by reversed-phase high performance liquid chromatography (RP-HPLC), characterized by electrospray-ionization mass spectrometry (ESI-MS), and metallated with (64)CuCl2 and (nat)CuCl2.	cupric chloride	218-223	gastrin releasing peptide receptor	Mus musculus	17-21
24508213-4	2014	The new bivalent GRPr/PSMA targeting vector was purified by reversed-phase high performance liquid chromatography (RP-HPLC), characterized by electrospray-ionization mass spectrometry (ESI-MS), and metallated with (64)CuCl2 and (nat)CuCl2.	cupric chloride	233-238	gastrin releasing peptide receptor	Mus musculus	17-21
24213945-4	2014	Here, we studied the effect of physiological concentration of CuCl2 (muM range) on the activity of peripheral neurons using a preparation of nodose ganglion in vitro.	cupric chloride	62-67	latexin	Homo sapiens	69-72
23391964-1	2013	The reactions of enantiopure chiral ligands (+)/(-)-4,5-pinenepyridyl-2-pyrazine (LS/LR) with CuCl2 2H2O in CH3OH/CH2Cl2 solution led to the formations of one-dimensional homochiral enantiomeric pairs with the formula [Cu(LR/S)Cl2]n 2H2O (R-1 and S-1, the isomers containing the LR and LS ligands, respectively).	cupric chloride	94-104	CD1b molecule	Homo sapiens	233-250
22170165-5	2012	RESULTS: PET-CT analysis demonstrated higher (64)Cu radioactivity in the liver of Atp7b                            (-/-) knockout mice compared with that in the control C57BL WT mice (p < 0.001), following oral administration of (64)CuCl(2) as a tracer.	cupric chloride	233-240	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	82-87
22170165-12	2012	CONCLUSIONS: PET-CT quantitative analysis demonstrated an increased level of (64)Cu radioactivity in the liver of Atp7b                            (-/-) KO mice compared with that in the control C57BL WT mice, following oral administration of (64)CuCl(2) as a tracer.	cupric chloride	247-254	ATPase, Cu++ transporting, beta polypeptide	Mus musculus	114-119
24473150-3	2014	In this work, metal salts aluminum chloride, calcium chloride, cupric chloride, ferric chloride, potassium chloride, magnesium chloride and sodium chloride were tested for their ability to inhibit AChE.	cupric chloride	63-78	acetylcholinesterase (Cartwright blood group)	Homo sapiens	197-201
23578282-2	2013	In the case of 2,2-dialkynyl-1,2-diols, bearing an additional alkynyl substituent at C-2, a cascade process, corresponding to copper-catalyzed heterocyclodehydration followed by acid-catalyzed hydration of the triple bond, was realized when the reaction was carried out in the presence of both CuCl2 and TsOH, leading to 3-acylfurans in one step and high yields (75-84%).	cupric chloride	294-299	complement C2	Homo sapiens	85-88
23285694-9	2012	GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in fibroblasts.	cupric chloride	10-15	tumor necrosis factor	Homo sapiens	53-62
23285694-9	2012	GGH, GHK, CuCl2 and their copper complexes decreased TNF-alpha-dependent IL-6 secretion in fibroblasts.	cupric chloride	10-15	interleukin 6	Homo sapiens	73-77
20970483-4	2011	We additionally investigated the binding kinetics of two recombinant human antibodies with different specificities recognizing epitopes of apoB-100 in surface-bound native and CuCl2-oxidized LDL (oxLDL).	cupric chloride	176-181	apolipoprotein B	Homo sapiens	139-147
22233278-4	2012	The reaction of HL1 with CuCl(2) gives a mononuclear [Cu(II)(HL1)(2)Cl(2)] (1) complex for which the crystal structure shows that HL1 is preserved.	cupric chloride	25-32	intelectin 1	Homo sapiens	16-19
22233278-4	2012	The reaction of HL1 with CuCl(2) gives a mononuclear [Cu(II)(HL1)(2)Cl(2)] (1) complex for which the crystal structure shows that HL1 is preserved.	cupric chloride	25-32	intelectin 1	Homo sapiens	61-64
22233278-4	2012	The reaction of HL1 with CuCl(2) gives a mononuclear [Cu(II)(HL1)(2)Cl(2)] (1) complex for which the crystal structure shows that HL1 is preserved.	cupric chloride	25-32	intelectin 1	Homo sapiens	61-64
21318477-2	2011	After application of CuCl(2) (30 muM) the specific cellular copper content increased from initial 1.5 +- 0.2 nmol/mg to a steady state level of 7.9 +- 0.9 nmol/mg within about 12 h. The copper accumulation was accompanied by a significant increase in the extracellular lactate concentration.	cupric chloride	21-28	latexin	Homo sapiens	33-36
22239859-10	2012	In conclusion, these studies show that sublethal exposure to copper (as copper chloride) induces toxicity in the thymus and spleen, and increased Sub G0/G1 population among splenocytes and thymocytes that is mediated, in part, by the EndoG-Bax-ubiquitin pathway.	cupric chloride	72-87	endonuclease G	Mus musculus	234-239
22239859-10	2012	In conclusion, these studies show that sublethal exposure to copper (as copper chloride) induces toxicity in the thymus and spleen, and increased Sub G0/G1 population among splenocytes and thymocytes that is mediated, in part, by the EndoG-Bax-ubiquitin pathway.	cupric chloride	72-87	BCL2-associated X protein	Mus musculus	240-243
22183913-2	2012	Positive ion electrospray mass spectra of aqueous solutions of CuCl(2)  and uracil show that the [Cu(Ura-H)(Ura)](+)  ion is the most abundant ion even at low concentrations of uracil.	cupric chloride	63-70	urate (hydroxyiso-) hydrolase, pseudogene	Homo sapiens	101-106
23028994-7	2012	Virulence of the thioredoxin 1 mutant was restored by trans-complementation with redox-active variants of thioredoxin 1 or, surprisingly, by exposing the thioredoxin 1 mutant to sublethal concentrations of the disulphide catalyst copper chloride prior to infection.	cupric chloride	230-245	Thioredoxin-1	Caenorhabditis elegans	17-30
21455704-4	2011	Further investigation indicated that the membrane potential determined by rhodamine 123 release decreased after CuCl(2) exposure at 30 and 50 muM.	cupric chloride	112-119	latexin	Homo sapiens	142-145
20945374-7	2011	We analyzed the 2 h-acute toxicity of CuCl(2) in terms of actin depolymerization and metallothionein 2A (MT2A) and heat shock protein 70 (HSPA1A) genes induction.	cupric chloride	38-45	metallothionein 2A	Homo sapiens	85-103
20945374-7	2011	We analyzed the 2 h-acute toxicity of CuCl(2) in terms of actin depolymerization and metallothionein 2A (MT2A) and heat shock protein 70 (HSPA1A) genes induction.	cupric chloride	38-45	metallothionein 2A	Homo sapiens	105-109
20945374-7	2011	We analyzed the 2 h-acute toxicity of CuCl(2) in terms of actin depolymerization and metallothionein 2A (MT2A) and heat shock protein 70 (HSPA1A) genes induction.	cupric chloride	38-45	heat shock protein family A (Hsp70) member 1A	Homo sapiens	138-144
19041202-7	2009	The results have revealed that Fry"s reagent comprising cupric chloride 90 g, hydrochloric acid 120 mL and water 100mL provided the necessary contrast and was concluded to be the most sensitive.	cupric chloride	56-71	FRY microtubule binding protein	Homo sapiens	31-34
19143551-5	2009	In the presence of CuCl2 in the subphase, Cu2+ ions coordinate to the headgroups of OA and EDA in the monolayers; moreover a new peak at 1220 cm(-1) is observed for the EDA monolayer and assigned to the CH2 twisting and wagging modes relevant to the ethylenediamine headgroups.	cupric chloride	19-24	ectodysplasin A	Homo sapiens	91-94
19143551-5	2009	In the presence of CuCl2 in the subphase, Cu2+ ions coordinate to the headgroups of OA and EDA in the monolayers; moreover a new peak at 1220 cm(-1) is observed for the EDA monolayer and assigned to the CH2 twisting and wagging modes relevant to the ethylenediamine headgroups.	cupric chloride	19-24	ectodysplasin A	Homo sapiens	169-172
19924324-5	2009	Using XPS and STM we have investigated the formation of the CuCl(2) like surface species and propose that it derives from the unusual reactivity of transient copper adatoms released from the p(2 x 1)O by the exothermic formation of water.	cupric chloride	60-67	sulfotransferase family 1A member 3	Homo sapiens	14-17
18097500-5	2008	In combination, however, homocysteine and CuCl(2) markedly increased O(2)(.-) formation, an effect blocked by SOD, catalase, apocynin, and sildenafil (1 micromol/L) when co-incubated over the same time course.	cupric chloride	42-49	catalase	Oryctolagus cuniculus	115-123
18782764-6	2008	Selection for resistance to elevated CuCl2 concentrations led to the isolation of FkpA-DsbA mutants containing a single amino acid substitution that changed the active site of the DsbA domain from CPHC into CPYC, increasing the similarity to the DsbC active site (CGYC).	cupric chloride	37-42	putative protein DsbC	Escherichia coli	246-250
18664522-4	2008	The near-UV CD spectra showed a marked change of PCaP1 in CuCl(2) solution.	cupric chloride	58-65	plasma-membrane associated cation-binding protein 1	Arabidopsis thaliana	49-54
18834119-1	2008	Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant.	cupric chloride	104-109	Sp2 transcription factor	Homo sapiens	45-48
18834119-1	2008	Pd(II)-catalyzed intramolecular amination of sp2 and sp3 C-H bonds are developed using a combination of CuCl2 and AgOAc as the oxidant.	cupric chloride	104-109	Sp3 transcription factor	Homo sapiens	53-56
18664522-9	2008	The PCaP1 solution was titrated with CuCl(2) and the change in the fluorescence spectrum was monitored to characterize Cu(2+)-binding properties.	cupric chloride	37-44	plasma-membrane associated cation-binding protein 1	Arabidopsis thaliana	4-9
18077536-9	2008	After intravenous administration of either (64)Cu-TP3939 or (64)CuCl(2) in PC3 xenografts and in transgenic mice, PET/CT images were acquired.	cupric chloride	64-71	proprotein convertase subtilisin/kexin type 1	Mus musculus	75-78
18077536-15	2008	Binding of (64)CuCl(2) to PC3 was nonspecific.	cupric chloride	15-22	proprotein convertase subtilisin/kexin type 1	Mus musculus	26-29
18386505-1	2008	A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide.	cupric chloride	147-166	superoxide dismutase 1	Homo sapiens	94-97
18386505-1	2008	A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide.	cupric chloride	147-166	superoxide dismutase 1	Homo sapiens	202-205
18386505-1	2008	A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide.	cupric chloride	147-166	superoxide dismutase 1	Homo sapiens	202-205
18386505-1	2008	A Notable decrease of the peak intensity of the capillary electrophoregram due to the dimeric SOD molecule was observed when a solution containing copper(II) chloride and ascorbic acid was added to the SOD solution, indicating that the capillary electrophoresis method is useful to detect the dissociation of the dimeric SOD molecule in solution, and that dissociation of the dimeric SOD molecule is induced by the presence of hydrogen peroxide.	cupric chloride	147-166	superoxide dismutase 1	Homo sapiens	202-205
16961344-0	2006	Antiferromagnetic interaction achieved by a 3-D supramolecular CuII complex with pyrazino-fused TTF as the ligand, [CuCl2(BP-TTF)].	cupric chloride	116-121	ras homolog family member H	Homo sapiens	96-99
17927914-9	2007	The results of expression analysis showed that GhACS1 displayed its transient expression nature after wounding, abscisic acid (ABA), and CuCl(2) treatments.	cupric chloride	137-144	1-aminocyclopropane-1-carboxylate synthase-like	Gossypium hirsutum	47-53
17617060-11	2007	Expression of hCTR1 resulted in strong activation of the reporter, with maximal induction at 1 muM CuCl2, consistent with the K(m) of hCTR1.	cupric chloride	99-104	solute carrier family 31 member 1	Homo sapiens	14-19
17617060-12	2007	Interestingly, expression of hCTR2 significantly induced MRE-luciferase reporter activation in a copper-dependent manner at 40 and 100 microM CuCl2.	cupric chloride	142-147	solute carrier family 31 member 2	Homo sapiens	29-34
17563785-2	2007	Surprisingly, the nature of the copper precursor is important in the synthesis of 1, with the reaction between Cu(NO3)2.3H2O, HL(1) and NEt3 giving [Cu6(micro(3)-OMe)4(micro-OMe)2(L(1))6] 2 instead of the anticipated 1, which was obtained with CuCl2.2H2O under the same conditions.	cupric chloride	244-254	tetraspanin 2	Homo sapiens	136-140
16961344-0	2006	Antiferromagnetic interaction achieved by a 3-D supramolecular CuII complex with pyrazino-fused TTF as the ligand, [CuCl2(BP-TTF)].	cupric chloride	116-121	ras homolog family member H	Homo sapiens	125-128
16961344-1	2006	The diffusion reaction of TBA2Cu(II)Cl4 (TBA = tetrabutylammonium) and a N-containing organic donor, BP-TTF [=bis(pyrazino)tetrathiafulvalene], yielded a 3-D supramolecular Cu complex, [CuCl2(BP-TTF)] (1).	cupric chloride	186-191	ras homolog family member H	Homo sapiens	104-107
16471974-2	2006	The reactions between CuCl2, Cu(OAc)2, and CuSO4 and the two bipyridylurea ligands L1 and L2 [L1 = 1,3-bis(pyridin-4-ylmethyl)urea; L2 = 1,3-bis(pyridin-3-ylmethyl)urea; see Scheme 1 in paper] have been carried out and the crystal structure of five of the resulting metal-organic assemblies determined.	cupric chloride	22-27	L1 cell adhesion molecule	Homo sapiens	83-92
16436375-5	2006	The phenotype associated with the reactive, altered state could be replicated by exposing oocytes expressing T338C CFTR to CuCl2, but not by glutathionylation or nitrosylation of the thiol or by oxidation with hydrogen peroxide.	cupric chloride	123-128	CF transmembrane conductance regulator	Homo sapiens	115-119
16615933-2	2006	The oxidative inactivation of ALR2 induced by CuCl2 at the stoichiometric Cu2+/ALR2 ratio of 2/1 [I. Cecconi, M. Moroni, P.G.	cupric chloride	46-51	lens aldose reductase pseudogene	Bos taurus	30-34
16615933-2	2006	The oxidative inactivation of ALR2 induced by CuCl2 at the stoichiometric Cu2+/ALR2 ratio of 2/1 [I. Cecconi, M. Moroni, P.G.	cupric chloride	46-51	lens aldose reductase pseudogene	Bos taurus	79-83
16445893-2	2006	The decrease of eta of the HA solution, indicating degradation of the biopolymer, was induced by a system containing H2O2 alone or H2O2 plus CuCl2.	cupric chloride	141-146	endothelin receptor type A	Homo sapiens	16-19
16471974-4	2006	Particularly interesting, because of their potential as nanoporous materials, are the assemblies obtained from the reaction between each of the two ligands (L1 and L2) and CuCl2, which yield noninterpenetrating 2D metal-organic layers made of squares of ca.	cupric chloride	172-177	L1 cell adhesion molecule	Homo sapiens	157-166
15741220-4	2005	Here we show that copper (CuCl(2)) stabilizes nuclear HIF-1alpha under normoxic conditions, resulting in hypoxia-response element (HRE)-dependent reporter gene expression.	cupric chloride	26-33	hypoxia inducible factor 1, alpha subunit	Mus musculus	54-64
16075120-4	2005	In contrast, reaction of [Pt2(mu-S)2(PPh3)4] with CuCl2 and NH3 in methanol gave the intensely blue methoxy-bridged dicopper complex [{Pt(2)(mu-S)2(PPh3)4Cu(OMe)}2]2+, isolated as its hexafluorophosphate salt.	cupric chloride	50-55	caveolin 1	Homo sapiens	37-41
16075120-4	2005	In contrast, reaction of [Pt2(mu-S)2(PPh3)4] with CuCl2 and NH3 in methanol gave the intensely blue methoxy-bridged dicopper complex [{Pt(2)(mu-S)2(PPh3)4Cu(OMe)}2]2+, isolated as its hexafluorophosphate salt.	cupric chloride	50-55	caveolin 1	Homo sapiens	148-152
15953645-10	2005	Antiproliferative activities of ([CuCl2(L1)2]) and [CuCl2(H2L2)]Cl, where HL2 is the 5-thioxo analog of L1, against human tumor cell lines HT1080 and HT29 as well as normal human fibroblasts (HF) are presented along with the antiproliferative activities of L1, CuCl2, and cisplatin.	cupric chloride	52-57	asialoglycoprotein receptor 2	Homo sapiens	74-77
15960548-0	2005	Efficient and reusable PdCl2(MeCN)2/CuCl2/PEG-400 system for cyclization of alkenyl beta-keto esters and amides.	cupric chloride	36-41	phosducin like 2	Homo sapiens	23-28
16220354-1	2005	PURPOSE: This study was conducted to assess the positron-emitting copper (II)-64 chloride ((64)CuCl(2)) as a probe for imaging mouse extrahepatic hepatoma expressing mouse copper transporter 1 (mCtr1) with positron emission tomography (PET).	cupric chloride	95-102	solute carrier family 31, member 1	Mus musculus	172-192
16220354-1	2005	PURPOSE: This study was conducted to assess the positron-emitting copper (II)-64 chloride ((64)CuCl(2)) as a probe for imaging mouse extrahepatic hepatoma expressing mouse copper transporter 1 (mCtr1) with positron emission tomography (PET).	cupric chloride	95-102	solute carrier family 31, member 1	Mus musculus	194-199
16220354-7	2005	CONCLUSIONS: The extrahepatic mouse hepatoma grafts may be visualized by Cu-64 PET, taking advantage of the (64)CuCl(2) uptake mediated by the functional endogenous mCtr1.	cupric chloride	112-119	solute carrier family 31, member 1	Mus musculus	165-170
15812313-4	2005	Motoneuron-neuroblastoma hybrid (VSC 4.1) cells expressing mutant SOD1, when treated with copper chloride, showed reduced viability and increased levels of endogenous peroxides.	cupric chloride	90-105	superoxide dismutase 1	Homo sapiens	66-70
15721899-5	2005	Copper chloride on the activated carbon in a range of 3-20 wt% Cu content was present mostly in the amorphous form of CuCl(2), according to the results of the solubility, XRD and TGA tests.	cupric chloride	0-15	T-box transcription factor 1	Homo sapiens	179-182
15173313-0	2004	p53-dependent apoptotic mechanism of a new designer bimetallic compound tri-phenyl tin benzimidazolethiol copper chloride (TPT-CuCl2): in vivo studies in Wistar rats as well as in vitro studies in human cervical cancer cells.	cupric chloride	106-121	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3
15104205-5	2004	SeP delayed the CuCl2- and AAPH-induced LDL oxidation significantly and more efficiently than bovine serum albumin used as control.	cupric chloride	16-21	selenoprotein P	Homo sapiens	0-3
15104205-7	2004	The protection of LDL against CuCl2- and AAPH-induced oxidation provides evidence for the antioxidant capacity of SeP.	cupric chloride	30-35	selenoprotein P	Homo sapiens	114-117
12940749-8	2003	Stern-Volmer plots of syn-2 in the presence of CuCl(2) showed a sigmoidal quenching curve indicating cooperative recognition, whereas a linear response was observed with CuCl and ZnCl(2).	cupric chloride	47-54	synapsin II	Homo sapiens	22-27
12067251-8	2002	Treatment of p53 cDNA with micromolar concentrations of (+/-)-anti-7,8-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene, (anti-BPDE, an ultimate carcinogen) or sub-micromolar concentrations of BP-7,8-dione in the presence of redox-cycling conditions (NADPH and CuCl(2)) also caused p53 mutations in a dose-dependent manner.	cupric chloride	278-285	tumor protein p53	Homo sapiens	13-16
12865660-4	2003	Increased IL-8 in the culture medium of human umbilical vein (HUVEC), lung microvascular, and iliac artery endothelial cells was observed 24 h after the addition of 10 to 50 microM CuCl2 (cupric ions).	cupric chloride	181-186	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
12865660-6	2003	HUVEC IL-8 mRNA increased 3 h after CuCl2 stimulation and remained elevated after 24 h, implying sustained transcriptional activation.	cupric chloride	36-41	C-X-C motif chemokine ligand 8	Homo sapiens	6-10
12526661-1	2003	Reaction of 5,5-dimethyl-8-nonene-2,4-dione catalyzed by PdCl2(CH3CN)2 (5 mol %) in the presence of CuCl2 (2.5 equiv) at room temperature for 3 h formed 2-acetyl-3,6,6-trimethyl-2-cyclohexenone in 96% isolated yield.	cupric chloride	100-105	phosducin like 2	Homo sapiens	57-62
11370844-6	2001	The used cytosol fraction contained 1.37 mM total Cu and 5 mM DTNB titrable-SH groups has a potential to reduce 2 mM CuCl2.	cupric chloride	117-122	dystrobrevin, beta	Rattus norvegicus	62-66
11931660-5	2002	Our data demonstrate that the COX deficiency observed in fibroblasts, myoblasts and myotubes from patients with SCO2 mutations can be restored to almost normal levels by the addition of CuCl(2) to the growth medium.	cupric chloride	186-193	cytochrome c oxidase subunit 8A	Homo sapiens	30-33
11931660-5	2002	Our data demonstrate that the COX deficiency observed in fibroblasts, myoblasts and myotubes from patients with SCO2 mutations can be restored to almost normal levels by the addition of CuCl(2) to the growth medium.	cupric chloride	186-193	synthesis of cytochrome C oxidase 2	Homo sapiens	112-116
11880116-0	2002	Effect of CuCl2, NaCl and EDTA on the enzyme alpha-L-iduronidase in the plasma of normal individuals and heterozygotes for MPS I.	cupric chloride	10-15	alpha-L-iduronidase	Homo sapiens	45-64
11880116-3	2002	METHODS: We evaluated the effect of copper chloride, EDTA and sodium chloride on the activity of the enzyme alpha-L-iduronidase in the plasma of normal individuals and of MPS I heterozygotes and observed the type of inhibition caused, the Ki, the apparent Km and the apparent Vmax for each inhibitor.	cupric chloride	36-51	alpha-L-iduronidase	Homo sapiens	108-127
11880116-6	2002	CONCLUSIONS: We detected significant differences capable of differentiating MPS I heterozygotes from normal individuals by simply adding sodium chloride, EDTA or copper chloride to the incubation medium at the time of IDUA activity determination, with a potential use in carrier detection protocols.	cupric chloride	162-177	alpha-L-iduronidase	Homo sapiens	218-222
11506017-1	2001	Experimentally, CCl4 was effectively mineralized by CuO to yield stable inorganic species of CO2 and CuCl2 (CCl4 + 2CuO --&gt; 2CuCl2 + CO2).	cupric chloride	101-106	C-C motif chemokine ligand 4	Homo sapiens	16-20
11506017-1	2001	Experimentally, CCl4 was effectively mineralized by CuO to yield stable inorganic species of CO2 and CuCl2 (CCl4 + 2CuO --&gt; 2CuCl2 + CO2).	cupric chloride	101-106	C-C motif chemokine ligand 4	Homo sapiens	108-112
11506017-3	2001	Using X-ray-absorption near edge structure (XANES) and X-ray photoelectron spectroscopies, we found that most CuCl2 was encapsulated in the CCl4-mineralized product solid (mineralization at 513 K for 30 min).	cupric chloride	110-115	C-C motif chemokine ligand 4	Homo sapiens	140-144
11506017-6	2001	Bond distances of Cu-O and Cu-Cl in the CCl4-mineralized product solid were 1.93-1.94 and 2.10-2.12 , respectively, which were greater than those of normal CuO and CuCl2 by 0.03-0.07 A.	cupric chloride	164-169	C-C motif chemokine ligand 4	Homo sapiens	40-44
11456415-4	2001	Fluorescence was also detected in Drosophila S2 tissue culture cells after induction of metallothionein synthesis by addition of CuCl2 to the growth medium.	cupric chloride	129-134	Metallothionein D	Drosophila melanogaster	88-103
11314951-5	2001	The lipoxygenase inhibitor ibuprofen suppressed the accumulation of HDMBOA-Glc induced by CuCl2 treatment, and the reduced accumulation of HDMBOA-Glc was recovered by addition of JA.	cupric chloride	90-95	linoleate 9S-lipoxygenase4	Zea mays	4-16
10413500-10	1999	In addition, the human FGF-1 C131S mutant showed a decrease in homodimer formation when exposed to CuCl(2).	cupric chloride	99-106	fibroblast growth factor 1	Homo sapiens	23-28
11124219-9	2001	The taste threshold in tap water was 2.6 mg/l Cu for both copper sulfate and copper chloride.	cupric chloride	77-92	nuclear RNA export factor 1	Homo sapiens	23-26
11342034-7	2001	Absorption spectra of histatin 5 at increasing copper chloride concentrations resulted in higher absorbance in the 230-280 nm wavelength range and this spectral change was saturated at a peptide:metal molar ratio of approx.	cupric chloride	47-62	histatin 3	Homo sapiens	22-32
11232828-2	2000	The reaction of copper(II) chloride with H2L1 leads not to a syn-anti carboxylate-bridged compound but to the chloride-bridged dinuclear complex [Cu(HL1)(mu-Cl)]2 (6).	cupric chloride	16-35	dynein axonemal heavy chain 5	Homo sapiens	149-152
10600810-5	1999	Treatment with CuCl(2) produced a concentration-dependent reduction in the staining of F actin but not of the junctional proteins zonula occludens-1, occludin, and E-cadherin and produced ultrastructural alterations to microvilli and tight junctions that were not observed after treatment with up to 200 microM Cu(His)(2) for 3 h. Overall, these data point to an intracellular effect of copper on tight junctions, mediated by perturbations of the F actin cytoskeleton.	cupric chloride	15-22	occludin	Homo sapiens	150-158
10600810-5	1999	Treatment with CuCl(2) produced a concentration-dependent reduction in the staining of F actin but not of the junctional proteins zonula occludens-1, occludin, and E-cadherin and produced ultrastructural alterations to microvilli and tight junctions that were not observed after treatment with up to 200 microM Cu(His)(2) for 3 h. Overall, these data point to an intracellular effect of copper on tight junctions, mediated by perturbations of the F actin cytoskeleton.	cupric chloride	15-22	cadherin 1	Homo sapiens	164-174
10080689-6	1999	Additional characterization of ACS6 gene expression indicated that the gene is also induced by wounding, and by treatment with LiCl, NaCl, CuCl2, auxin, cycloheximide (CHX), aminooxyacetic acid (AOA) and ethylene.	cupric chloride	139-144	1-aminocyclopropane-1-carboxylic acid (acc) synthase 6	Arabidopsis thaliana	31-35
10064141-9	1999	Like alkaline phosphatase, cyclic PIP-degrading enzymes require Mg2+ and they are inhibited by heavy metal ions such as mercuric and copper chloride, by sodium fluoride and interestingly, by prostaglandins.	cupric chloride	133-148	prolactin induced protein	Rattus norvegicus	34-37
8733936-5	1996	Catalase and neocuproine nearly completely inhibited strand break formation induced by aromatic aldehydes/CuCl2.	cupric chloride	106-111	catalase	Homo sapiens	0-8
9287301-4	1997	Bovine S100b protein was found to suppress dose-dependently the hemolysis of mouse erythrocytes induced by CuCl2.	cupric chloride	107-112	S100 calcium binding protein B	Bos taurus	7-12
11666847-5	1996	[CuCl(Me(3)tpa)][CuCl(2)(Me(3)tpa)]ClO(4) (4) crystallized in the monoclinic system, space group P2(1)/a, with a = 15.698(6) A, b = 14.687(7) A, c = 19.475(4) A, beta = 97.13(2) degrees, and Z = 4 (R = 0.054, R(w) = 0.038).	cupric chloride	17-24	H3 histone pseudogene 16	Homo sapiens	97-102
9437199-3	1997	We evaluated the production of platelet-activating factor (PAF), a potent inflammatory mediator, in human LDL subspecies on copper-initiated oxidation (4 mumol/L CuCl2, 80 micrograms/mL for hours at 37 degrees C).	cupric chloride	162-167	PCNA clamp associated factor	Homo sapiens	31-57
9437199-3	1997	We evaluated the production of platelet-activating factor (PAF), a potent inflammatory mediator, in human LDL subspecies on copper-initiated oxidation (4 mumol/L CuCl2, 80 micrograms/mL for hours at 37 degrees C).	cupric chloride	162-167	PCNA clamp associated factor	Homo sapiens	59-62
9051619-4	1997	Diethyldithiocarbamate (2 mM) inhibited CuZn SOD activity in supernatant fractions of muscle homogenates by 34% (P &lt; 0.01, n = 5), an effect reversed by CuCl2 (2 mM).	cupric chloride	156-161	superoxide dismutase 1	Rattus norvegicus	40-48
8951230-11	1996	FeCl(3) was ineffective, suggesting that CuCl(2) but not FeCl(3) mediates oxidation of PCB dihydroxy metabolites, resulting in oxidative DNA damage.	cupric chloride	41-48	pyruvate carboxylase	Homo sapiens	87-90
8951230-12	1996	The addition of catalase (100 U/mL) and sodium azide (0.1 M) reduced the effect of CuCl(2) (849 and 896 8-oxodG/10(6) nucleotides, respectively), while superoxide dismutase (600 U/mL) moderately stimulated and glutathione (100 microM) substantially stimulated 8-oxodG formation (3014 and 4415 8-oxodG/10(6) nucleotides, respectively).	cupric chloride	83-90	catalase	Homo sapiens	16-24
7546771-6	1995	The presence of cupric chloride in the culture medium during the incubation of the CdR cells for 16 h significantly enhanced lysyl oxidase activity accumulating in the medium, suggesting that lysyl oxidase deficiency in CdR cells may be related to abnormal copper metabolism.	cupric chloride	16-31	lysyl oxidase	Mus musculus	125-138
7546771-6	1995	The presence of cupric chloride in the culture medium during the incubation of the CdR cells for 16 h significantly enhanced lysyl oxidase activity accumulating in the medium, suggesting that lysyl oxidase deficiency in CdR cells may be related to abnormal copper metabolism.	cupric chloride	16-31	lysyl oxidase	Mus musculus	192-205
8491675-8	1993	A modified, direct-colouring AChE-method is presented, which uses copper chloride as source of cupric ions, acetylthiocholine chloride as substrate and 2-morpholinoethanesulphonic acid (MES) as buffer.	cupric chloride	66-81	acetylcholinesterase	Bos taurus	29-33
7627705-4	1995	Oxidation mediated by copper ions resulted in a significant inactivation of LDL-associated TFPI (60% to 72% at 24 hours with 2.5 mumol/l CuCl2).	cupric chloride	137-142	tissue factor pathway inhibitor	Homo sapiens	91-95
1510681-3	1992	Mature brain-derived neurotrophic factor was extracted from E. coli inclusion bodies, refolded in the presence of CuCl2 and purified.	cupric chloride	114-119	brain-derived neurotrophic factor	Rattus norvegicus	7-40
27280676-0	1992	Accumulation of Isoflavones in Lupin Seedings Treated with Copper Chloride.	cupric chloride	59-74	5'-nucleotidase, cytosolic IIIA	Homo sapiens	31-36
1428539-6	1992	The effectiveness of copper(II) chloride was confirmed also in the BOP-Cl method.	cupric chloride	21-40	BOP	Homo sapiens	67-70
1399263-1	1992	Copper(II) chloride was found to be an extremely efficient racemization-suppressing additive in the DCC method as compared with the hitherto known ones, by employing the model coupling Z-Gly-L-Val-OH + H-L-Val-OMe in DMF.	cupric chloride	0-19	DCC netrin 1 receptor	Homo sapiens	100-103
33762296-7	2021	After treatment with CuCl2 followed by DTC for 15 min, the levels of CuET and Cu2+ in hCTR1-overexpressed cells was 2.5-fold higher than that of vector group.	cupric chloride	21-26	solute carrier family 31 member 1	Homo sapiens	86-91
33821628-4	2021	Here, we synthesize 0D chiral copper chloride hybrids, templated by chiral methylbenzylammonium (R/S-MBA), i.e., (R-/S-MBA)2CuCl4, that display circular dichroism for the ligand-to-metal charge transfer transition with an absorption anisotropy factor (gCD) among the largest reported for chiral metal halide semiconductor hybrids.	cupric chloride	30-45	guanylate cyclase 2E, pseudogene	Homo sapiens	252-255
34396788-7	2021	Incubation of osteoblasts with the OGR1 inhibitor CuCl2 inhibited the MET induced increase in RGS16 mRNA.	cupric chloride	50-55	G protein-coupled receptor 68	Mus musculus	35-39
34898033-5	2022	Moreover, a CuCl2 @MOF-867 based probe demonstrated highly selective and sensitive aqueous phase recognition of CN- ions even in the presence of other interfering anions such as Br- , NO3 - , I- , SO4 2- , OAc- , SCN- , NO2 - , etc.	cupric chloride	12-17	sorcin	Homo sapiens	178-223
34426160-0	2021	CuCl2-catalyzed inexpensive, faster and ligand/additive free synthesis of isoquinolin-1(2H)-one derivatives via the coupling-cyclization strategy: Evaluation of a new class of compounds as potential PDE4 inhibitors.	cupric chloride	0-5	phosphodiesterase 4A	Homo sapiens	199-203
34396788-7	2021	Incubation of osteoblasts with the OGR1 inhibitor CuCl2 inhibited the MET induced increase in RGS16 mRNA.	cupric chloride	50-55	regulator of G-protein signaling 16	Mus musculus	94-99
33875094-7	2021	In contrast, in the control (CuCl2) treated samples showed mostly changes in inflammation mainly through regulation of the Nuclear Factor Kappa-light-chain-enhancer of Activated B-cells (NFkappaB).	cupric chloride	29-34	nuclear factor kappa B subunit 1	Homo sapiens	187-195
35266459-2	2022	Specifically, Pt1,2Cu bi/tri-atoms are prepared by reducing CuCl2 at preformed Pt1 atoms with ethanol inside a PDMS-PEG protective layer.	cupric chloride	60-65	zinc finger protein 77	Homo sapiens	14-17
34510751-3	2021	Herein, a novel Cu anchored on hollow carbon spheres catalysts (HCS/Cu-x, x represents the mass of CuCl2 added in the system) is designed with controllable copper/carbon heterogenous interfaces.	cupric chloride	99-104	holocarboxylase synthetase	Homo sapiens	64-67
34510751-3	2021	Herein, a novel Cu anchored on hollow carbon spheres catalysts (HCS/Cu-x, x represents the mass of CuCl2 added in the system) is designed with controllable copper/carbon heterogenous interfaces.	cupric chloride	99-104	cut like homeobox 1	Homo sapiens	68-72
35266459-2	2022	Specifically, Pt1,2Cu bi/tri-atoms are prepared by reducing CuCl2 at preformed Pt1 atoms with ethanol inside a PDMS-PEG protective layer.	cupric chloride	60-65	zinc finger protein 77	Homo sapiens	79-82