PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25189993-2	2014	In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-101, a synthetic derivative of the polyprenylated acylphloroglucinol (PPAP) natural products, with an IC(50) for SIRT1 of 30 microM in vitro, with 5-fold higher activity for SIRT1 vs. SIRT2.	jq-101	116-122	sirtuin 1	Homo sapiens	100-105
25189993-2	2014	In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-101, a synthetic derivative of the polyprenylated acylphloroglucinol (PPAP) natural products, with an IC(50) for SIRT1 of 30 microM in vitro, with 5-fold higher activity for SIRT1 vs. SIRT2.	jq-101	116-122	sirtuin 1	Homo sapiens	232-237
25189993-2	2014	In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-101, a synthetic derivative of the polyprenylated acylphloroglucinol (PPAP) natural products, with an IC(50) for SIRT1 of 30 microM in vitro, with 5-fold higher activity for SIRT1 vs. SIRT2.	jq-101	116-122	sirtuin 1	Homo sapiens	232-237
25189993-2	2014	In this study, we screened derivatives of several groups of natural products and identified a novel SIRT1 inhibitor JQ-101, a synthetic derivative of the polyprenylated acylphloroglucinol (PPAP) natural products, with an IC(50) for SIRT1 of 30 microM in vitro, with 5-fold higher activity for SIRT1 vs. SIRT2.	jq-101	116-122	sirtuin 2	Homo sapiens	303-308
25189993-3	2014	Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target.	jq-101	27-33	tumor protein p53	Homo sapiens	72-75
25189993-3	2014	Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target.	jq-101	27-33	sirtuin 1	Homo sapiens	112-117
25189993-3	2014	Exposure of tumor cells to JQ-101 significantly enhanced acetylation of p53 and histone H4K16 at known sites of SIRT1 deacetylation, validating SIRT1 as its cellular target.	jq-101	27-33	sirtuin 1	Homo sapiens	144-149
25189993-6	2014	In summary, we have identified JQ-101 as a new SIRT1 inhibitor which may have potential application in cancer treatment through its ability to induce tumor cell apoptosis and senescence and suppress cancer cell invasion.	jq-101	31-37	sirtuin 1	Homo sapiens	47-52