PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19996293-2	2009	All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2).	isocitric acid	79-89	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	112-116
19996293-2	2009	All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1 and the analogous R172 residue of IDH2).	isocitric acid	79-89	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	151-155
18806796-2	2008	Affected family members were homozygous for loss-of-function mutations in IDH3B, encoding the beta-subunit of NAD-specific isocitrate dehydrogenase (NAD-IDH, or IDH3), which is believed to catalyze the oxidation of isocitrate to alpha-ketoglutarate in the citric acid cycle.	isocitric acid	123-133	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	Homo sapiens	74-79
19935646-2	2009	These mutations occur at a single amino acid residue of the IDH1 active site, resulting in loss of the enzyme"s ability to catalyse conversion of isocitrate to alpha-ketoglutarate.	isocitric acid	146-156	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	60-64
19375412-9	2009	DRS with a customized library and quantitation database was able to clearly separate co-eluting compounds including those with very similar mass spectra such as citric acid and isocitric acid.	isocitric acid	177-191	sushi repeat containing protein X-linked	Homo sapiens	0-3
18271541-1	2008	Isocitrate lyase (ICL, EC 4.1.3.1) is commonly present in oil-rich seeds in catalyzing the cleavage of isocitrate to glyoxylate and succinate and plays an essential role in lipid metabolism and gluconeogenesis.	isocitric acid	103-113	isocitrate lyase 1	Glycine max	18-21
16489927-3	2006	AsAT from the rat liver was specified by substrate inhibition and also by changes in the enzyme affinity for the substrates under the influence of some intermediates of the tricarboxylic acid cycle: isocitrate, succinate, fumarate, and citrate.	isocitric acid	199-209	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	0-4
17432878-1	2007	Human NAD-dependent isocitrate dehydrogenase (IDH) is allosterically activated by ADP by lowering the Km for isocitrate.	isocitric acid	20-30	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	46-49
17135241-4	2007	Under the assay conditions, no significant FIH inhibition was observed by the TCAIs or pyruvate, but fumarate, succinate, and isocitrate inhibited PHD2.	isocitric acid	126-136	egl-9 family hypoxia inducible factor 1	Homo sapiens	147-151
17432878-5	2007	The alpha-D181N IDH mutant exhibits a 2000-fold decrease in Vmax, with increases of 15-fold in the Kms for Mn(II) and NAD and a much smaller change in the Km for isocitrate.	isocitric acid	162-172	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	16-19
16636309-1	2006	The cytosolic NADP+-dependent isocitrate dehydrogenase (IDH1) catalyzes the conversion of isocitrate to alpha-ketoglutarate in the cytosol, and generates NADPH as a primary source of reducing equivalents for de novo fatty acid synthesis in bovine mammary gland.	isocitric acid	30-40	isocitrate dehydrogenase [NADP] cytoplasmic	Bos taurus	56-60
15574419-3	2005	However, with respect to isocitrate, IDP1 had an apparent Km value approximately 7-fold lower than that of IDP2, whereas, with respect to alpha-ketoglutarate, IDP2 had an apparent Km value approximately 10-fold lower than that of IDP1.	isocitric acid	25-35	isocitrate dehydrogenase (NADP(+)) IDP1	Saccharomyces cerevisiae S288C	37-41
15636585-8	2005	When expressed in mammalian cells, IRP1(S711E) completely fails to bind to RNA and to generate isocitrate from citrate.	isocitric acid	95-105	aconitase 1	Homo sapiens	35-39
15574419-9	2005	Collectively, these results suggest an ancillary role for IDP1 in cellular glutamate synthesis and a role for IDP2 in equilibrating and maintaining cellular levels of isocitrate and alpha-ketoglutarate.	isocitric acid	167-177	isocitrate dehydrogenase (NADP(+)) IDP2	Saccharomyces cerevisiae S288C	110-114
15001388-1	2004	Three differentially compartmentalized isozymes of isocitrate dehydrogenase (mitochondrial IDP1, cytosolic IDP2, and peroxisomal IDP3) in the yeast Saccharomyces cerevisiae catalyze the NADP(+)-dependent oxidative decarboxylation of isocitrate to form alpha-ketoglutarate.	isocitric acid	51-61	isocitrate dehydrogenase (NADP(+)) IDP1	Saccharomyces cerevisiae S288C	91-95
15557328-4	2005	Apart from its ability to convert citrate to iso-citrate, IRP1 in its apo-form binds to iron-responsive elements in the untranslated regions of mRNAs coding for proteins involved in iron metabolism, to regulate their synthesis and thus control the cellular homeostasis of this metal.	isocitric acid	45-56	aconitase 1	Mus musculus	58-62
15327944-5	2004	Cytosolic aconitase (aco-1), iron regulatory protein, is known to regulate cellular iron concentration by modulating translation of the ferritin mRNA in addition to its enzymatic activity that converts citrate into iso-citrate.	isocitric acid	215-226	Cytoplasmic aconitate hydratase	Caenorhabditis elegans	21-26
15327944-5	2004	Cytosolic aconitase (aco-1), iron regulatory protein, is known to regulate cellular iron concentration by modulating translation of the ferritin mRNA in addition to its enzymatic activity that converts citrate into iso-citrate.	isocitric acid	215-226	Ferritin	Caenorhabditis elegans	136-144
15063794-6	2004	IDPc is known to generate NADPH, a cellular reducing agent, via oxidative decarboxylation of isocitrate.	isocitric acid	93-103	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
15001388-1	2004	Three differentially compartmentalized isozymes of isocitrate dehydrogenase (mitochondrial IDP1, cytosolic IDP2, and peroxisomal IDP3) in the yeast Saccharomyces cerevisiae catalyze the NADP(+)-dependent oxidative decarboxylation of isocitrate to form alpha-ketoglutarate.	isocitric acid	51-61	isocitrate dehydrogenase (NADP(+)) IDP2	Saccharomyces cerevisiae S288C	107-111
15001388-1	2004	Three differentially compartmentalized isozymes of isocitrate dehydrogenase (mitochondrial IDP1, cytosolic IDP2, and peroxisomal IDP3) in the yeast Saccharomyces cerevisiae catalyze the NADP(+)-dependent oxidative decarboxylation of isocitrate to form alpha-ketoglutarate.	isocitric acid	51-61	isocitrate dehydrogenase (NADP(+)) IDP3	Saccharomyces cerevisiae S288C	129-133
12562755-9	2003	These results are consistent with previous studies demonstrating that the catalytic isocitrate binding sites are comprised of residues primarily contributed by IDH2, whereas sites for regulatory binding of isocitrate are contributed by analogous residues of IDH1.	isocitric acid	84-94	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	160-164
12820873-2	2003	Holo-IRP1 containing a [4Fe-4S] cluster exhibits aconitase activity which catalyzes the isomerization of citrate and isocitrate.	isocitric acid	117-127	aconitase 1	Homo sapiens	5-9
12562755-9	2003	These results are consistent with previous studies demonstrating that the catalytic isocitrate binding sites are comprised of residues primarily contributed by IDH2, whereas sites for regulatory binding of isocitrate are contributed by analogous residues of IDH1.	isocitric acid	206-216	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	258-262
12562755-10	2003	In this study, we also demonstrate that a prerequisite for holoenzyme binding of NAD(+) is binding of isocitrate/Mg(2+) at the IDH2 catalytic site.	isocitric acid	102-112	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	127-131
12562755-11	2003	This is comparable to the dependence of AMP binding upon binding of isocitrate at the IDH1 regulatory site.	isocitric acid	68-78	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	86-90
12207025-10	2002	The consensus IDH mechanism predicts that the Mn2+-bound hydroxyl of isocitrate is deprotonated prior to its NADP+-dependent oxidation.	isocitric acid	69-79	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	14-17
11042198-2	2001	IDH2 was previously shown to contain the catalytic site, whereas IDH1 contributes regulatory properties including cooperativity with respect to isocitrate and allosteric activation by AMP.	isocitric acid	144-154	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	0-4
11953438-2	2002	Ligand-binding analyses were conducted to examine effects of residue changes in putative catalytic and regulatory isocitrate-binding sites respectively contained in IDH2 and IDH1 subunits.	isocitric acid	114-124	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	165-169
11953438-2	2002	Ligand-binding analyses were conducted to examine effects of residue changes in putative catalytic and regulatory isocitrate-binding sites respectively contained in IDH2 and IDH1 subunits.	isocitric acid	114-124	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	174-178
11953438-3	2002	Replacement of homologous serine residues in either subunit site, S98A in IDH2 or S92A in IDH1, was found to reduce by half the total number of holoenzyme isocitrate-binding sites, confirming a correlation between detrimental effects on isocitrate binding and respective kinetic defects in catalysis and allosteric activation by AMP.	isocitric acid	155-165	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	74-78
11953438-3	2002	Replacement of homologous serine residues in either subunit site, S98A in IDH2 or S92A in IDH1, was found to reduce by half the total number of holoenzyme isocitrate-binding sites, confirming a correlation between detrimental effects on isocitrate binding and respective kinetic defects in catalysis and allosteric activation by AMP.	isocitric acid	155-165	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	90-94
11953438-5	2002	The putative isocitrate-binding sites of IDH1 and IDH2 contain five identical and four nonidentical residues.	isocitric acid	13-23	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	41-45
11953438-5	2002	The putative isocitrate-binding sites of IDH1 and IDH2 contain five identical and four nonidentical residues.	isocitric acid	13-23	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	50-54
11953438-8	2002	Finally, the mutant enzymes with residue replacements in the IDH1 site were found to be unable to bind AMP, suggesting that allosteric activation is dependent both upon binding of isocitrate at the IDH1 site and upon the changes in the enzyme normally elicited by this binding.	isocitric acid	180-190	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	61-65
11953438-8	2002	Finally, the mutant enzymes with residue replacements in the IDH1 site were found to be unable to bind AMP, suggesting that allosteric activation is dependent both upon binding of isocitrate at the IDH1 site and upon the changes in the enzyme normally elicited by this binding.	isocitric acid	180-190	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	198-202
11714283-9	2001	However, single or multiple residue replacements in IDH1 uniformly increased half-saturation concentrations for isocitrate, implying that isocitrate can be bound at this site.	isocitric acid	112-122	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	52-56
11714283-9	2001	However, single or multiple residue replacements in IDH1 uniformly increased half-saturation concentrations for isocitrate, implying that isocitrate can be bound at this site.	isocitric acid	138-148	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	52-56
11714283-11	2001	Overall, results are consistent with isocitrate binding by IDH2 for catalysis and with isocitrate binding by IDH1 being a prerequisite for allosteric activation by AMP.	isocitric acid	37-47	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	59-63
11714283-11	2001	Overall, results are consistent with isocitrate binding by IDH2 for catalysis and with isocitrate binding by IDH1 being a prerequisite for allosteric activation by AMP.	isocitric acid	87-97	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	109-113
11284679-1	2001	Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate and has negligible activity toward other (R)-malate-type substrates.	isocitric acid	74-84	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
11284679-1	2001	Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate and has negligible activity toward other (R)-malate-type substrates.	isocitric acid	74-84	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
11284679-2	2001	The S113E mutant of IDH significantly improves its ability to utilize isopropylmalate as a substrate and switches the substrate specificity (k(cat)/K(M)) from isocitrate to isopropylmalate.	isocitric acid	159-169	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	20-23
11042198-2	2001	IDH2 was previously shown to contain the catalytic site, whereas IDH1 contributes regulatory properties including cooperativity with respect to isocitrate and allosteric activation by AMP.	isocitric acid	144-154	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	65-69
11042198-9	2001	A K189A substitution in IDH2 was found to produce a decrease in activation of the enzyme by AMP and a loss of cooperativity with respect to isocitrate.	isocitric acid	140-150	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	24-28
11087384-1	2000	Despite the structural similarities between isocitrate and isopropylmalate, isocitrate dehydrogenase (IDH) exhibits a strong preference for its natural substrate.	isocitric acid	44-54	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	76-100
11085915-5	2000	By means of an Fe-S-cluster-dependent switch, IRP-1 can function as an mRNA-binding protein or as an enzyme that converts citrate into isocitrate.	isocitric acid	135-145	aconitase 1	Homo sapiens	46-51
11087384-1	2000	Despite the structural similarities between isocitrate and isopropylmalate, isocitrate dehydrogenase (IDH) exhibits a strong preference for its natural substrate.	isocitric acid	44-54	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	102-105
10799480-2	2000	Mitochondrial aconitase (m-aconitase) contains a [4Fe-4S](2+) cluster in its active site that catalyzes the stereospecific dehydration-rehydration of citrate to isocitrate in the Krebs cycle.	isocitric acid	161-171	aconitase 2	Homo sapiens	0-23
10799480-2	2000	Mitochondrial aconitase (m-aconitase) contains a [4Fe-4S](2+) cluster in its active site that catalyzes the stereospecific dehydration-rehydration of citrate to isocitrate in the Krebs cycle.	isocitric acid	161-171	aconitase 2	Homo sapiens	25-36
9512021-9	1998	The analysis is extended to the case where the second substrate of IDH, isocitrate, is consumed in the course of the reaction without being regenerated.	isocitric acid	72-82	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	67-70
9518625-1	1998	A substrate cycle between citric acid cycle (CAC) intermediates isocitrate and 2-oxoglutarate, involving NAD+- and NADP+-linked isocitrate dehydrogenase (NAD-IDH and NADP-IDH, respectively) and mitochondrial transhydrogenase (H+-Thase), has recently been proposed.	isocitric acid	64-74	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	158-161
9518625-1	1998	A substrate cycle between citric acid cycle (CAC) intermediates isocitrate and 2-oxoglutarate, involving NAD+- and NADP+-linked isocitrate dehydrogenase (NAD-IDH and NADP-IDH, respectively) and mitochondrial transhydrogenase (H+-Thase), has recently been proposed.	isocitric acid	64-74	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	171-174
9244391-8	1997	Citrate and isocitrate concentrations were also elevated in the idh2 mutants, but probably not to toxic levels.	isocitric acid	12-22	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	64-68
9891796-2	1998	In this pathway, two specific enzymes, isocitrate lyase and malate synthase, are activated to divert isocitrate from the tricarboxylic acid cycle and prevent the quantitative loss of acetate carbons as carbon dioxide.	isocitric acid	39-49	citramalyl-CoA lyase	Homo sapiens	60-75
9138670-5	1997	Isocitrate, a glial specific metabolic substrate, prevented the FAC-induced synaptic depression in both CA1 and DG.	isocitric acid	0-10	carbonic anhydrase 1	Cavia porcellus	104-107
8608121-0	1996	Synthesis, kinetics, and structural studies of a photolabile caged isocitrate: a catalytic trigger for isocitrate dehydrogenase.	isocitric acid	67-77	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	103-127
8608121-5	1996	Enzymatic conversion of the liberated isocitrate to alpha-ketoglutarate was achieved in solution as well as in wild-type and mutant isocitrate dehydrogenase (IDH) protein crystals.	isocitric acid	38-48	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	132-156
8608121-5	1996	Enzymatic conversion of the liberated isocitrate to alpha-ketoglutarate was achieved in solution as well as in wild-type and mutant isocitrate dehydrogenase (IDH) protein crystals.	isocitric acid	38-48	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	158-161
8608121-6	1996	The X-ray crystal structures of wild-type IDH soaked with photolabile caged isocitrate and Mg2+ and void of nicotinamide adenine dinucleotide phosphate were solved at 2.5 A resolution before and after photolysis and compared by difference mapping against previously determined enzyme structures.	isocitric acid	76-86	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	42-45
7755589-8	1995	Structural analysis of the deduced H-IDH alpha protein revealed that the amino acids responsible for the binding of isocitrate, Mg2+ and NAD+ are highly conserved.	isocitric acid	116-126	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	Homo sapiens	35-46
8698047-5	1996	Concentrations and ratios of NADP and isocitrate were adjusted to optimize NADPH generation by the S-9.	isocitric acid	38-48	ribosomal protein S9	Homo sapiens	99-102
7726553-6	1995	Increased Ca2+free not only increases this sensitivity to preincubation but also inhibits reductant transfer from succinate and isocitrate to both P450scc and P450(11) beta.	isocitric acid	128-138	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	147-154
7840619-4	1995	Substrate protection studies demonstrated that substrates for the tricarboxylate transporter (i.e., citrate, isocitrate, phosphoenolpyruvate, and malate) effectively protected against PLP inhibition, whereas other organic anions which are not transported by the tricarboxylate carrier (i.e., malonate, alpha-ketoglutarate, phosphate, and succinate) afforded considerably less protection.	isocitric acid	109-119	pyridoxal phosphatase	Homo sapiens	184-187
1648348-6	1991	Aconitase was purified over 135-fold to a specific activity of 32 mumol/min per mg (with isocitrate as substrate) from the matrix of potato tuber mitochondria.	isocitric acid	89-99	aconitate hydratase, cytoplasmic	Solanum tuberosum	0-9
8181473-7	1994	The affinity toward isocitrate was reduced in the cases of [S97T]ICDH and [N99L]ICDH, confirming the importance of the residues for the reaction.	isocitric acid	20-30	NADP-dependent isocitrate dehydrogenase	Thermus thermophilus HB8	65-69
8181473-7	1994	The affinity toward isocitrate was reduced in the cases of [S97T]ICDH and [N99L]ICDH, confirming the importance of the residues for the reaction.	isocitric acid	20-30	NADP-dependent isocitrate dehydrogenase	Thermus thermophilus HB8	80-84
8181473-9	1994	[N99L]ICDH showed an approximately 10(3)-fold higher value of (kcat/Km)3-ethylmalate/(kcat/Km)isocitrate than the wild-type enzyme, indicating that the single mutation of Asn99 to leucine switched the substrate specificity of the enzyme away from isocitrate and toward 3-ethylmalate.	isocitric acid	94-104	NADP-dependent isocitrate dehydrogenase	Thermus thermophilus HB8	6-10
8369302-6	1993	The IDH1 mutant enzyme was not activated by AMP, whereas the IDH2 mutant enzyme exhibited an increase in isocitrate affinity in the presence of AMP similar to that observed with the wild-type enzyme.	isocitric acid	105-115	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	61-65
8369302-0	1993	Kinetic analysis of NAD(+)-isocitrate dehydrogenase with altered isocitrate binding sites: contribution of IDH1 and IDH2 subunits to regulation and catalysis.	isocitric acid	27-37	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	116-120
8369302-3	1993	This mutation in IDH1 resulted in a 6-fold decrease in Vmax and a decrease in cooperativity, but little change in S0.5 for isocitrate.	isocitric acid	123-133	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	17-21
8369302-4	1993	The mutant IDH2, in contrast, exhibited a 60-fold decrease in maximal velocity and a 2-fold reduction in S0.5 for isocitrate, but the cooperativity was unaffected.	isocitric acid	114-124	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	11-15
8243798-8	1993	Only synergistic combinations of reductants are sufficient to sustain maximum rates of 11-deoxycorticosterone (DOC) metabolism, whereas IC is fully effective for P450scc.	isocitric acid	136-138	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	162-169
2176871-14	1990	Together, these results imply that enzyme-catalyzed interconversion of citrate and isocitrate does not involve displacement of an endogenous fourth ligand, but rather addition of the anionic carboxylate ligand and a change in protonation state of a solvent species bound to Fea.	isocitric acid	83-93	FEA	Homo sapiens	274-277
34968705-4	2022	The results reveal that isocitrate is blocked from conversion to alpha-ketoglutarate and that acetyl-coenzyme A (CoA) accumulates, which is consistent with a reduction in oxygen consumption rate and inactivation of isocitrate dehydrogenase (IDH) activity.	isocitric acid	24-34	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	215-239
2221921-11	1990	On the other hand, 200 microM 3MP blocked completely the epimastigotes" catabolism of L-[U-14C]proline through the Kreb"s cycle via PEP-carboxykinase, as indicated by the disappearance of 14C label present in alanine, pyruvate, citrate, and isocitrate after 1 h of incubation in the presence of the labeled amino acid, while the amount of radioactivity present in alpha-ketoglutarate and malate doubled.	isocitric acid	241-251	phosphoenolpyruvate carboxykinase 1	Homo sapiens	132-149
27655638-1	2016	Isocitrate dehydrogenase (IDH1) is an NADP-dependent enzyme that catalyzes the decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	98-108	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-30
12228600-4	1995	Reduction of AOX to its more active form could also be mediated by intramitochondrial reducing power generated by the oxidation of certain tricarboxylic acid cycle substrates, most notably isocitrate and malate.	isocitric acid	189-199	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	13-16
2176627-4	1990	Cholesterol SCC with 1 mM isocitrate exhibited 2-3 times more fast-phase metabolism, a pronounced slow phase, insensitivity to preincubation, and 60% depletion of spectrally detected cholesterol-P-450SCC complexes.	isocitric acid	26-36	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	195-203
2176627-5	1990	Addition of bovine serum albumin (BSA) and EDTA, either during homogenization or directly to the incubation, prevented preincubation losses in response to succinate and removed most of the difference between succinate and isocitrate activities.	isocitric acid	222-232	albumin	Rattus norvegicus	19-32
2198251-8	1990	Mitochondria isolated from the IDH1 and IDH2 mutants exhibited a markedly reduced capacity for utilization of either isocitrate or citrate for respiratory O2 consumption.	isocitric acid	117-127	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	31-35
2198251-8	1990	Mitochondria isolated from the IDH1 and IDH2 mutants exhibited a markedly reduced capacity for utilization of either isocitrate or citrate for respiratory O2 consumption.	isocitric acid	117-127	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	40-44
32796956-5	2021	It is well-known that IDH1 converts isocitrate to 2-oxoglutarate (2-OG), maintaining intracellular 2-OG homeostasis.	isocitric acid	36-46	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	22-26
34968705-4	2022	The results reveal that isocitrate is blocked from conversion to alpha-ketoglutarate and that acetyl-coenzyme A (CoA) accumulates, which is consistent with a reduction in oxygen consumption rate and inactivation of isocitrate dehydrogenase (IDH) activity.	isocitric acid	24-34	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	241-244
34854890-1	2021	Human isocitrate dehydrogenase (IDH) genes encode for the IDH1, 2 & 3 isoenzymes which catalyse the formation of 2-oxoglutarate from isocitrate and are essential for normal mammalian metabolism.	isocitric acid	133-143	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	6-30
34928443-7	2021	Malate, fumarate, pyruvate, alpha-ketoglutarate, lactate, succinate and citrate/isocitrate loaded positively on PC1; methylsuccinate, ethylmalonate and succinate loaded positively on PC2; and methylmalonate, ethylmalonate and citrate/isocitrate loaded negatively on PC3.	isocitric acid	80-90	proprotein convertase subtilisin/kexin type 1	Homo sapiens	112-115
34854890-1	2021	Human isocitrate dehydrogenase (IDH) genes encode for the IDH1, 2 & 3 isoenzymes which catalyse the formation of 2-oxoglutarate from isocitrate and are essential for normal mammalian metabolism.	isocitric acid	133-143	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	32-35
34854890-1	2021	Human isocitrate dehydrogenase (IDH) genes encode for the IDH1, 2 & 3 isoenzymes which catalyse the formation of 2-oxoglutarate from isocitrate and are essential for normal mammalian metabolism.	isocitric acid	133-143	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	58-62
34725432-5	2021	The isocitrate-Mg2+ complex is the preferred wt IDH1 substrate; with R132H IDH1, separate and weaker binding of 2-oxoglutarate and Mg2+ is preferred.	isocitric acid	4-14	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	48-52
34518298-7	2021	Lastly, we found that the glutaminase inhibitor CB-839 enhanced anti-leukemic effect of gilteritinib in ex vivo studies using human primary FLT3-ITD-positive AML cells harboring mutations in the enzyme isocitrate dehydrogenase, which catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate.	isocitric acid	277-287	fms related receptor tyrosine kinase 3	Homo sapiens	140-144
34495967-6	2021	All GABA pathway metabolites (gamma-hydroxybutyrate, glutamine, glutamate, total GABA, succinic semialdehyde) and TCA cycle metabolites (citrate, malate, fumarate, isocitrate, lactate) were significantly low in the homozygous knock-out aldh7a1 zebrafish compared to the wildtype zebrafish.	isocitric acid	164-174	aldehyde dehydrogenase 7 family, member A1	Danio rerio	236-243
35419827-7	2022	In fact, by studying the frequently silenced genes, we found that when the GPH1 gene is knocked out in S. cerevisiae, the isocitrate lyase enzyme is activated, which converts the isocitrate into succinate.	isocitric acid	179-189	glycogen phosphorylase	Saccharomyces cerevisiae S288C	75-79
34356864-2	2021	IDH enzymes catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG), an intermediate in the citric acid cycle.	isocitric acid	39-49	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3
34143606-2	2021	Wild-type (WT) IDH1 converts isocitrate to AKG; however, mutant IDH1-R132H that is recurrent in human cancers catalyzes the neomorphic production of the oncometabolite d-2-hydroxyglutrate (D-2HG) from AKG.	isocitric acid	29-39	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	15-19
34143606-2	2021	Wild-type (WT) IDH1 converts isocitrate to AKG; however, mutant IDH1-R132H that is recurrent in human cancers catalyzes the neomorphic production of the oncometabolite d-2-hydroxyglutrate (D-2HG) from AKG.	isocitric acid	29-39	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	64-68
34065652-1	2021	Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP+-dependent oxidation of isocitrate to alpha-ketoglutarate (alphaKG).	isocitric acid	86-96	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-30
35048959-7	2022	Further, citrate, isocitrate, and malate were observed to activate human LDH-A, both at pH 5.0 and 6.5, with citrate and isocitrate being responsible for major effects.	isocitric acid	18-28	lactate dehydrogenase A	Homo sapiens	73-78
35443173-3	2022	We find that IFNbeta simultaneously increased the expression of immune-responsive gene 1 and itaconate production while inhibiting isocitrate dehydrogenase activity and restricting alpha-ketoglutarate accumulation.	isocitric acid	131-141	IFN1@	Homo sapiens	13-20
35048959-7	2022	Further, citrate, isocitrate, and malate were observed to activate human LDH-A, both at pH 5.0 and 6.5, with citrate and isocitrate being responsible for major effects.	isocitric acid	121-131	lactate dehydrogenase A	Homo sapiens	73-78
3363677-2	1988	Isocitrate rather than NADP and MnCl2 protects two SH-groups of the enzyme from modification by DTNB and attendant inactivation.	isocitric acid	0-10	dystrobrevin beta	Bos taurus	96-100
2829741-11	1988	Uptake of alkanes into mitochondrial membranes may effect structural changes that facilitate outer to inner membrane cholesterol transfer, but major changes are excluded by the effectiveness of isocitrate as a reductant for P-450scc.	isocitric acid	194-204	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	224-232
6289094-3	1982	Total aryl hydrocarbon hydroxylase (AHH) activity was greater for the isocitrate dependent system, however, this yielded a lower level of HGPRT mutants.	isocitric acid	70-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	6-34
6414457-5	1983	The Km values for purified NADP-IDH are not different from those found for the purified control enzyme for NADP+ or isocitrate.	isocitric acid	116-126	Isocitrate dehydrogenase	Drosophila melanogaster	27-35
4074790-2	1985	The increase in the intracellular concentrations of isocitrate and alpha-ketoglutarate with a simultaneous decrease of malate in the liver of vitamin-deficient rats points to the inhibition of alpha-ketoglutarate dehydrogenase responsible for the anomalous metabolism under conditions of thiamine deficiency.	isocitric acid	52-62	oxoglutarate dehydrogenase	Rattus norvegicus	193-226
16663992-1	1985	The proton translocation coupled to the electron flux from succinate, exogenous NADH, and NAD(+)-linked substrates (malate and isocitrate) to cytochrome c and to oxygen was studied in purified potato (Solanum tuberosum) mitochondria using oxygen and ferricyanide pulse techniques.	isocitric acid	127-137	cytochrome c	Solanum tuberosum	142-154
6742863-6	1984	Under these experimental conditions the release of Ca2+ can be completely reversed if the rereduction of NAD(P)+ is brought about by the addition of the reductants beta-hydroxybutyrate and isocitrate.	isocitric acid	189-199	carbonic anhydrase 2	Homo sapiens	51-54
6289094-3	1982	Total aryl hydrocarbon hydroxylase (AHH) activity was greater for the isocitrate dependent system, however, this yielded a lower level of HGPRT mutants.	isocitric acid	70-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	36-39
4291561-9	1967	In the thorax, cytochrome c oxidase and the dehydrogenases for glycerophosphate, isocitrate (NAD-dependent), succinate and malate appeared initially in small particles (less than 1mu in diameter).	isocitric acid	81-91	Cytochrome c oxidase subunit 4	Drosophila melanogaster	15-35
6127688-7	1982	In line with the conclusions from the preceding paper, it is suggested that formation of an abortive complex of enzyme, Mg2+, isocitrate and NADPH under catalytic cycling conditions serves to by-pass the potentially rate-limiting dissociation of NADPH from the enzyme-Mg2+-NADPH complex.	isocitric acid	126-136	mucin 7, secreted	Homo sapiens	120-123
6127688-7	1982	In line with the conclusions from the preceding paper, it is suggested that formation of an abortive complex of enzyme, Mg2+, isocitrate and NADPH under catalytic cycling conditions serves to by-pass the potentially rate-limiting dissociation of NADPH from the enzyme-Mg2+-NADPH complex.	isocitric acid	126-136	mucin 7, secreted	Homo sapiens	268-271
7266074-6	1981	While pyruvate kinase and those mitochondrial enzymes lying between citrate formation and isocitrate oxidation (citrate synthase, NADP+-and NAD+-isocitrate dehydrogenases) decline to some degree, mitochondrial succinate dehydrogenase and NAD+-malate dehydrogenase activities increase over the same period.	isocitric acid	90-100	citrate synthase	Rattus norvegicus	112-128
38961-10	1979	(b) In a system where the rate of isocitrate oxidation is limited by the rate of NADPH reoxidation by glutathione reductase, the rate of glutathione reduction extrapolated to infinite alpha-methylisocitrate concentration was from 20--40% of the uninhibited rate.	isocitric acid	34-44	glutathione-disulfide reductase	Rattus norvegicus	102-123
29888-4	1978	The bound fumarase was released from the membrane by the substrates, isocitrate, citrate or 2,3-diphosphoglycerate at low concentrations.	isocitric acid	69-79	fumarate hydratase	Rattus norvegicus	10-18
950499-6	1976	Mg2+ stimulated isocitrate- and NADPH-dependent 26-hydroxylation of exogenous cholesterol but inhibited in the case of endogenous cholesterol.	isocitric acid	16-26	mucin 7, secreted	Homo sapiens	0-3
950499-9	1976	Isocitrate- and NADPH-dependent 26-hydroxylation of exogenous 5beta-cholestane-3alpha,7alpha,12alpha-triol differed from that of exogenous cholesterol in response to Mg2+ and Ca2+.	isocitric acid	0-10	mucin 7, secreted	Homo sapiens	166-169
12937-1	1976	Mitochondrial preparations isolated from rat ventral prostate were capable of oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NAD-IDH.	isocitric acid	88-98	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	145-148
12937-1	1976	Mitochondrial preparations isolated from rat ventral prostate were capable of oxidizing isocitrate by way of NADP isocitrate dehydrogenase (NADP-IDH) and NAD-IDH.	isocitric acid	88-98	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	158-161
12937-7	1976	The oxidation of isocitrate through IDH activity was coupled to the cytochrome system by NADPH- and NADH-cytochrome c reductase activities.	isocitric acid	17-27	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma	Rattus norvegicus	36-39
4387231-0	1969	Oxygen uptake and 14CO2 production from citrate and isocitrate by control and parathyroid hormone-treated bone maintained in tissue culture.	isocitric acid	52-62	complement C2	Homo sapiens	20-23
33981605-1	2021	Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	91-101	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
5929751-12	1966	Isocitrate was identified as the sole compound labeled when C(14)O(2) was added to a reduced nicotinamide adenine dinucleotide, CO(2) generating system (crystalline glucose-6-phosphate dehydrogenase and glucose-6-phosphate) in the presence of alpha-ketoglutarate.	isocitric acid	0-10	glucose-6-phosphate dehydrogenase	Homo sapiens	165-198
33981605-1	2021	Isocitrate dehydrogenase (IDH) is a key metabolic enzyme catalyzing the interconversion of isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	91-101	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
33321098-3	2021	Molecular or pharmacologic suppression of isocitrate dehydrogenase-2 (IDH2), which catalyzes reductive carboxylation of 2-ketoglutarate to isocitrate, results in impairment of glucose- and Gln + BCH-stimulated reductive TCA cycle flux, lowering of NADPH levels, and inhibition of insulin secretion.	isocitric acid	42-52	isocitrate dehydrogenase (NADP(+)) 2	Rattus norvegicus	70-74
32713659-1	2020	BACKGROUND: The ACO2 gene encodes mitochondrial aconitase, the enzyme involved in the second step of the tricarboxylic acid cycle, catalyzing the interconversion of citrate into isocitrate.	isocitric acid	178-188	aconitase 2	Homo sapiens	16-20
33649794-8	2021	Furthermore, Bcl2l10-knockdown induced the accumulation of succinate and isocitrate through the downregulation of SDHD and IDH1.	isocitric acid	73-83	BCL2 like 10	Homo sapiens	13-20
33649794-8	2021	Furthermore, Bcl2l10-knockdown induced the accumulation of succinate and isocitrate through the downregulation of SDHD and IDH1.	isocitric acid	73-83	succinate dehydrogenase complex subunit D	Homo sapiens	114-118
33649794-8	2021	Furthermore, Bcl2l10-knockdown induced the accumulation of succinate and isocitrate through the downregulation of SDHD and IDH1.	isocitric acid	73-83	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	123-127
33713004-1	2021	BACKGROUND: Isocitrate dehydrogenase (IDH) is an important enzyme that oxidatively decarboxylates isocitrate to alpha-ketoglutarate, and three isoforms (IDH1-3) have been identified.	isocitric acid	98-108	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	12-36
33713004-1	2021	BACKGROUND: Isocitrate dehydrogenase (IDH) is an important enzyme that oxidatively decarboxylates isocitrate to alpha-ketoglutarate, and three isoforms (IDH1-3) have been identified.	isocitric acid	98-108	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	38-41
33499062-1	2021	The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases.	isocitric acid	26-36	capicua transcriptional repressor	Homo sapiens	46-49
32713659-1	2020	BACKGROUND: The ACO2 gene encodes mitochondrial aconitase, the enzyme involved in the second step of the tricarboxylic acid cycle, catalyzing the interconversion of citrate into isocitrate.	isocitric acid	178-188	aconitase 2	Homo sapiens	34-57
32727816-1	2020	Isocitrate dehydrogenase 1 (IDH1) encodes a protein which catalyses the oxidative decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	101-111	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
32880665-2	2020	We have explored how mutated isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate which in turn is converted to d-2-hydroxyglutatrate (d-2HG) as a preferred product instead of l-2-hydroxyglutatrate (l-2HG) according to quantum chemical calculations.	isocitric acid	29-39	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	55-58
32727816-1	2020	Isocitrate dehydrogenase 1 (IDH1) encodes a protein which catalyses the oxidative decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	101-111	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
32605922-6	2020	Moreover, S. aureus-induced ULBP2 expression was linked to altered host cell metabolism, including increased cytoplasmic (iso)citrate levels, reduced glycolytic flux, and functional mitochondrial activity.	isocitric acid	121-133	UL16 binding protein 2	Homo sapiens	28-33
32955829-1	2020	The isocitrate dehydrogenases enzymes, IDH1 and IDH2, catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG) in the cell cytoplasm and mitochondria, respectively, and contribute to generating the dihydronicotinamide-adenine dinucleotide phosphate (NADPH) as reductive potential in different cellular processes.	isocitric acid	4-14	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	39-43
32955829-1	2020	The isocitrate dehydrogenases enzymes, IDH1 and IDH2, catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG) in the cell cytoplasm and mitochondria, respectively, and contribute to generating the dihydronicotinamide-adenine dinucleotide phosphate (NADPH) as reductive potential in different cellular processes.	isocitric acid	4-14	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	48-52
32729927-1	2020	Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate to alpha-ketoglutarate (alphaKG) to provide critical cytosolic substrates and drive NADPH-dependent reactions like lipid biosynthesis and glutathione regeneration.	isocitric acid	89-99	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
32729927-1	2020	Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate to alpha-ketoglutarate (alphaKG) to provide critical cytosolic substrates and drive NADPH-dependent reactions like lipid biosynthesis and glutathione regeneration.	isocitric acid	89-99	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
32729927-1	2020	Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate to alpha-ketoglutarate (alphaKG) to provide critical cytosolic substrates and drive NADPH-dependent reactions like lipid biosynthesis and glutathione regeneration.	isocitric acid	89-99	2,4-dienoyl-CoA reductase 1	Homo sapiens	184-189
32764267-1	2020	Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate with concurrent reduction of NADP+ to NADPH.	isocitric acid	30-40	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	56-60
32373065-13	2020	Conclusion: IDH1 plays an important role in cholangiocarcinoma and its mutation impairs tumor progression in part by inhibition of isocitrate metabolism.	isocitric acid	131-141	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	12-16
32449285-1	2020	The mitochondrial aconitase gene (ACO2) encodes an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle.	isocitric acid	102-112	aconitase 2	Homo sapiens	4-27
32449285-1	2020	The mitochondrial aconitase gene (ACO2) encodes an enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle.	isocitric acid	102-112	aconitase 2	Homo sapiens	34-38
32777735-3	2020	Cancer-associated substitutions in IDH1 and IDH2 impair wild-type production of 2-oxoglutarate and reduced nicotinamide adenine dinucleotide phosphate (NADPH) from isocitrate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+ ), and substantially promote the IDH variant catalysed conversion of 2-oxoglutarate to d-2-hydroxyglutarate (d-2HG).	isocitric acid	164-174	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	35-39
32777735-3	2020	Cancer-associated substitutions in IDH1 and IDH2 impair wild-type production of 2-oxoglutarate and reduced nicotinamide adenine dinucleotide phosphate (NADPH) from isocitrate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+ ), and substantially promote the IDH variant catalysed conversion of 2-oxoglutarate to d-2-hydroxyglutarate (d-2HG).	isocitric acid	164-174	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	44-48
32777735-3	2020	Cancer-associated substitutions in IDH1 and IDH2 impair wild-type production of 2-oxoglutarate and reduced nicotinamide adenine dinucleotide phosphate (NADPH) from isocitrate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+ ), and substantially promote the IDH variant catalysed conversion of 2-oxoglutarate to d-2-hydroxyglutarate (d-2HG).	isocitric acid	164-174	2,4-dienoyl-CoA reductase 1	Homo sapiens	107-158
32777735-3	2020	Cancer-associated substitutions in IDH1 and IDH2 impair wild-type production of 2-oxoglutarate and reduced nicotinamide adenine dinucleotide phosphate (NADPH) from isocitrate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+ ), and substantially promote the IDH variant catalysed conversion of 2-oxoglutarate to d-2-hydroxyglutarate (d-2HG).	isocitric acid	164-174	2,4-dienoyl-CoA reductase 1	Homo sapiens	107-151
32777735-3	2020	Cancer-associated substitutions in IDH1 and IDH2 impair wild-type production of 2-oxoglutarate and reduced nicotinamide adenine dinucleotide phosphate (NADPH) from isocitrate and oxidised nicotinamide adenine dinucleotide phosphate (NADP+ ), and substantially promote the IDH variant catalysed conversion of 2-oxoglutarate to d-2-hydroxyglutarate (d-2HG).	isocitric acid	164-174	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	35-38
32212192-1	2020	Mitochondrial aconitase (Aco2) catalyzes the conversion of citrate to isocitrate in the TCA cycle, which produces NADH and FADH2, driving synthesis of ATP through OXPHOS.	isocitric acid	70-80	aconitase 2, mitochondrial	Mus musculus	25-29
32291392-1	2020	Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis.	isocitric acid	81-91	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
32291392-1	2020	Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate and therefore play key roles in the Krebs cycle and cellular homoeostasis.	isocitric acid	81-91	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
31485826-2	2020	IDH enzyme normally catalyzes isocitrate to alpha-keto-glutarate (alpha-KG), but once the gene is mutated it produces an "oncometabolite", 2-hydroxyglutarate (2-HG).	isocitric acid	30-40	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3
31819175-2	2020	Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far.	isocitric acid	74-84	aconitase 2	Homo sapiens	0-11
31819175-2	2020	Aconitase 2 (ACO2) participates in the TCA cycle by converting citrate to isocitrate, but no evident demonstrations of its involvement in cancer metabolism have been provided so far.	isocitric acid	74-84	aconitase 2	Homo sapiens	13-17
31479775-2	2019	Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the decarboxylation of isocitrate to alpha-ketoglutarate, accompanied by NADPH production.	isocitric acid	30-40	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	56-60
31561044-1	2019	Isocitrate dehydrogenase 1 (IDH1), which catalyzes the conversion of isocitrate to alpha-ketoglutarate, is one of key enzymes in the tricarboxylic acid cycle (TCA).	isocitric acid	69-79	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	0-26
31561044-1	2019	Isocitrate dehydrogenase 1 (IDH1), which catalyzes the conversion of isocitrate to alpha-ketoglutarate, is one of key enzymes in the tricarboxylic acid cycle (TCA).	isocitric acid	69-79	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	28-32
31478653-1	2019	Human isocitrate dehydrogenase 1 (HsICDH1) is a cytoplasmic homodimeric Mg(II)-dependent enzyme that converts d-isocitrate (D-ICT) and NADP+ to alpha-ketoglutarate (AKG), CO2, and NADPH.	isocitric acid	110-122	2,4-dienoyl-CoA reductase 1	Homo sapiens	180-185
30862724-4	2019	Mechanistically, Y42 phosphorylation occurs in IDH1 monomers, which promotes dimer formation with enhanced substrate (isocitrate or alpha-ketoglutarate) binding, whereas Y42-phosphorylated dimers show attenuated disruption to monomers.	isocitric acid	118-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	47-51
31257503-2	2019	By catalyzing the reversible conversion between isocitrate and alpha-ketoglutarate (alpha-KG), IDH1 and 2 contribute to the central process of metabolism, including oxidative and reductive metabolism.	isocitric acid	48-58	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	95-105
31257503-9	2019	Finally, [U-13C5]glutamine tracer analysis showed that IDH2 knockdown reduced the reductive carboxylation of alpha-KG into isocitrate in HCT116R132H/+ cells under hypoxic conditions.	isocitric acid	123-133	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	55-59
31064654-3	2019	Isocitrate dehydrogenase 2 (IDH2), localized in mitochondria, decreases NADP+ to NADPH during the decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	117-127	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	0-26
31064654-3	2019	Isocitrate dehydrogenase 2 (IDH2), localized in mitochondria, decreases NADP+ to NADPH during the decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	117-127	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	28-32
30972978-4	2019	ACO2 is a Krebs cycle enzyme that converts citrate to isocitrate and is sensitive to reactive oxygen species (ROS)-mediated damage.	isocitric acid	54-64	aconitase 2	Homo sapiens	0-4
31191018-10	2019	Furthermore, isoform 1 of LINC00477 was determined to interact with ACO1 and suppress the conversion ability from citrate to isocitrate by ACO1.	isocitric acid	125-135	long intergenic non-protein coding RNA 477	Homo sapiens	26-35
31191018-10	2019	Furthermore, isoform 1 of LINC00477 was determined to interact with ACO1 and suppress the conversion ability from citrate to isocitrate by ACO1.	isocitric acid	125-135	aconitase 1	Homo sapiens	68-72
31191018-10	2019	Furthermore, isoform 1 of LINC00477 was determined to interact with ACO1 and suppress the conversion ability from citrate to isocitrate by ACO1.	isocitric acid	125-135	aconitase 1	Homo sapiens	139-143
30689204-1	2019	Mitochondrial aconitase is the second enzyme in the tricarboxylic acid (TCA) cycle catalyzing the interconversion of citrate into isocitrate and encoded by the nuclear gene ACO2.	isocitric acid	130-140	aconitase 2	Homo sapiens	0-23
31105869-1	2019	The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and IDH2 are required for the decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	14-24	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	40-43
31105869-1	2019	The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and IDH2 are required for the decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	14-24	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	90-94
31105869-1	2019	The family of isocitrate dehydrogenase (IDH) enzymes is vital for cellular metabolism, as IDH1 and IDH2 are required for the decarboxylation of isocitrate to alpha-ketoglutarate.	isocitric acid	14-24	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	99-103
30526058-5	2019	This PCAF-regulated post-translational modification might reduce IDH2 affinity for isocitrate as a result of a conformational shift involving predictively the tyrosine at position 179.	isocitric acid	83-93	K(lysine) acetyltransferase 2B	Mus musculus	5-9
30526058-5	2019	This PCAF-regulated post-translational modification might reduce IDH2 affinity for isocitrate as a result of a conformational shift involving predictively the tyrosine at position 179.	isocitric acid	83-93	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	65-69
30689204-1	2019	Mitochondrial aconitase is the second enzyme in the tricarboxylic acid (TCA) cycle catalyzing the interconversion of citrate into isocitrate and encoded by the nuclear gene ACO2.	isocitric acid	130-140	aconitase 2	Homo sapiens	173-177
30478029-1	2018	Isocitrate dehydrogenase (IDH) is an enzyme required for the production of alpha-ketoglutarate from isocitrate.	isocitric acid	100-110	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	0-24
30478029-1	2018	Isocitrate dehydrogenase (IDH) is an enzyme required for the production of alpha-ketoglutarate from isocitrate.	isocitric acid	100-110	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	26-29
29847930-1	2018	Isocitrate dehydrogenases 1 and 2 (IDH1/2) are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) in the tricarboxylic acid cycle.	isocitric acid	99-109	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	35-41
30506321-1	2018	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate.	isocitric acid	88-98	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	34-38
30506321-1	2018	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate.	isocitric acid	88-98	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	43-47
30006485-2	2018	These highly effective gain-of-function mutations enable mutant IDH to efficiently metabolize isocitrate to D-2-hydroxyglutarate (D 2-HG) that accumulates to high concentrations within the tumor microenvironment.	isocitric acid	94-104	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	64-67
30006485-2	2018	These highly effective gain-of-function mutations enable mutant IDH to efficiently metabolize isocitrate to D-2-hydroxyglutarate (D 2-HG) that accumulates to high concentrations within the tumor microenvironment.	isocitric acid	94-104	immunoglobulin heavy diversity 2-15	Homo sapiens	108-128
30003571-1	2018	AIMS: Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that converts isocitrate to alpha-ketoglutarate.	isocitric acid	76-86	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	6-32
30003571-1	2018	AIMS: Isocitrate dehydrogenase 1 (IDH1) is a metabolic enzyme that converts isocitrate to alpha-ketoglutarate.	isocitric acid	76-86	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	34-38
29723602-1	2018	Isocitrate dehydrogenases 1 and 2 (IDH1/2) are important metabolic enzymes that convert isocitrate to alpha-ketoglutarate.	isocitric acid	88-98	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	35-41
30249606-2	2018	Most tumor-relevant IDH1 mutations are deficient in the normal oxidization of isocitrate to alpha-ketoglutarate (alphaKG), but gain the neomorphic activity of reducing alphaKG to D-2-hydroxyglutarate (D2HG), which drives tumorigenesis.	isocitric acid	78-88	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	20-24
30405699-2	2018	This is exemplified by the isoforms of isocitrate dehydrogenase (IDH1/2), which metabolize isocitrate to alpha-Ketoglutarate (alpha-KG).	isocitric acid	39-49	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	65-71
29769206-4	2018	IDH2 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate; its mutated version leads to the accumulation of the oncometabolite (R)-2 hydroxyglutarate, which disrupts several cell processes and leads to a blockage in differentiation.	isocitric acid	66-76	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	0-4
29913148-4	2018	Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) has been reported as an essential enzyme catalyzing the conversion of isocitrate to alpha-KG with concurrent production of NAPDH.	isocitric acid	30-40	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	56-60
29773061-1	2018	Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG).	isocitric acid	108-118	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	35-39
29923039-2	2018	NADP+-dependent cytosolic isocitrate dehydrogenase (IDH) provides reducing energy to counteract oxidative stress via oxidative decarboxylation of isocitrate.	isocitric acid	26-36	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	52-55
29953513-3	2018	Wild type IDH1 catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) whereas mutant IDH1 converts alpha-KG into D2-hydroxyglutarate (D2HG).	isocitric acid	54-64	isocitrate dehydrogenase (NADP(+)) 1	Danio rerio	10-14
29953513-3	2018	Wild type IDH1 catalyzes oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) whereas mutant IDH1 converts alpha-KG into D2-hydroxyglutarate (D2HG).	isocitric acid	54-64	isocitrate dehydrogenase (NADP(+)) 1	Danio rerio	114-118
29226520-2	2018	SLC25A1 encodes the mitochondrial citrate carrier (CIC), which mediates efflux of the mitochondrial tricarboxylic acid (TCA) cycle intermediates citrate and isocitrate in exchange for cytosolic malate.	isocitric acid	157-167	solute carrier family 25 member 1	Homo sapiens	0-7
30013764-3	2018	IDH2 enzyme is involved in the Krebs cycle, catalyzing alpha-ketoglutarate from isocitrate.	isocitric acid	80-90	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	0-4
29651790-1	2018	BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) is a dimeric enzyme responsible for supplying the cell"s nicotinamide adenine dinucleotide phosphate (NADPH) reserves via dehydrogenation of isocitrate (ICT) and reduction of NADP+.	isocitric acid	187-197	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	12-38
29651790-1	2018	BACKGROUND: Isocitrate dehydrogenase 1 (IDH1) is a dimeric enzyme responsible for supplying the cell"s nicotinamide adenine dinucleotide phosphate (NADPH) reserves via dehydrogenation of isocitrate (ICT) and reduction of NADP+.	isocitric acid	187-197	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	40-44
29651790-2	2018	Mutations in position R132 trigger cancer by enabling IDH1 to produce D-2-hydroxyglutarate (2-HG) and reduce inhibition by ICT.	isocitric acid	123-126	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	54-58
29567975-1	2018	Isocitrate dehydrogenase (IDH) 2 participates in the TCA cycle and catalyzes the conversion of isocitrate to alpha-ketoglutarate and NADP+ to NADPH.	isocitric acid	95-105	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	0-32
29773061-1	2018	Isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG).	isocitric acid	108-118	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	44-48
28827794-0	2017	Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).	isocitric acid	0-10	Parkinsonism associated deglycase	Homo sapiens	20-24
29318542-1	2018	Mitochondrial aconitase is a reversible enzyme that catalyzes the conversion of citrate to isocitrate in the tricarboxylic acid cycle.	isocitric acid	91-101	aconitase 2	Homo sapiens	0-23
29290954-6	2017	IDH2 catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG), an essential cofactor for the TET family of 5-methylcytosine (5mC) hydroxylases that convert 5-mC to 5-hydroxymethylcytosine (5-hmC).	isocitric acid	48-58	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	0-4
28720665-6	2017	Finally, a truncating germline IDH3B mutation was found in a patient with a single paraganglioma showing an altered alpha-ketoglutarate/isocitrate ratio.Conclusions: This study further attests to the relevance of the Krebs cycle in the development of PCC and PGL, and points to a potential role of other metabolic enzymes involved in metabolite exchange between mitochondria and cytosol.	isocitric acid	136-146	isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta	Homo sapiens	31-36
28803913-9	2017	In addition, our result suggests that cytosolic isocitrate dehydrogenase (IDP2) may be regulated by isocitrate pools.	isocitric acid	48-58	isocitrate dehydrogenase (NADP(+)) IDP2	Saccharomyces cerevisiae S288C	74-78
28827794-0	2017	Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP+-dependent isocitrate dehydrogenase (IDH).	isocitric acid	0-10	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	121-124
28827794-3	2017	In RNA-sequencing analyses searching for novel anti-oxidant genes downstream of DJ-1, a gene encoding NADP+-dependent isocitrate dehydrogenase (IDH), which converts isocitrate into alpha-ketoglutarate, was detected.	isocitric acid	118-128	Parkinsonism associated deglycase	Homo sapiens	80-84
28827794-3	2017	In RNA-sequencing analyses searching for novel anti-oxidant genes downstream of DJ-1, a gene encoding NADP+-dependent isocitrate dehydrogenase (IDH), which converts isocitrate into alpha-ketoglutarate, was detected.	isocitric acid	118-128	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	144-147
28827794-7	2017	Consistently, trimethyl isocitrate (TIC), a cell permeable isocitrate, protected mammalian DJ-1 null DA cells from oxidative stress in an IDH-dependent manner.	isocitric acid	24-34	Parkinsonism associated deglycase	Homo sapiens	91-95
28827794-7	2017	Consistently, trimethyl isocitrate (TIC), a cell permeable isocitrate, protected mammalian DJ-1 null DA cells from oxidative stress in an IDH-dependent manner.	isocitric acid	24-34	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	138-141
28925723-4	2017	Although all three enzymes catalyze the same enzymatic reaction, that is, oxidative decarboxylation of isocitrate to produce alpha-ketoglutarate, each IDH enzyme has unique features.	isocitric acid	103-113	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	151-154
28665599-2	2017	In particular, we focus our attention on the ability of the -CF3 group to participate in noncovalent interactions as Lewis acids, and we show the importance of this interaction in the inhibition mechanism of a NADP+-dependent isocitrate dehydrogenase (IDH) enzyme that converts isocitrate to alpha-ketoglutarate.	isocitric acid	226-236	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	252-255
27568302-1	2017	Isocitrate dehydrogenase 1 (IDH1), one member of the IDH family can convert isocitrate to alpha-ketoglutarate (alpha-KG) via oxidative decarboxylation.	isocitric acid	76-86	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	0-26
27568302-1	2017	Isocitrate dehydrogenase 1 (IDH1), one member of the IDH family can convert isocitrate to alpha-ketoglutarate (alpha-KG) via oxidative decarboxylation.	isocitric acid	76-86	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	28-32
28330869-1	2017	Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) in the cytosol and peroxisomes.	isocitric acid	89-99	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
28330869-1	2017	Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) in the cytosol and peroxisomes.	isocitric acid	89-99	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
28330869-1	2017	Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) in the cytosol and peroxisomes.	isocitric acid	101-104	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
28330869-1	2017	Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) in the cytosol and peroxisomes.	isocitric acid	101-104	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
27821630-1	2017	Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance.	isocitric acid	30-40	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	56-60
27821630-1	2017	Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate, synthesizing NADPH, which is essential for mitochondrial redox balance.	isocitric acid	30-40	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	153-158
28536275-1	2017	The isocitrate dehydrogenase IDH2 produces alpha-ketoglutarate by oxidizing isocitrate, linking glucose metabolism to oxidative phosphorylation.	isocitric acid	4-14	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	29-33
28473643-7	2017	In contrast, G6pd deficiency resulted in increased activities and protein levels of cytosolic isocitrate dehydrogenase 1, an enzyme that catalyzes the conversion of isocitrate to alpha-ketoglutarate and NADP+ to NADPH, in the inner ear.	isocitric acid	94-104	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	212-217
28705010-1	2017	Isocitrate dehydrogenases (IDH) are important enzymes that catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG), producing NADPH in the process.	isocitric acid	101-111	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-25
28705010-1	2017	Isocitrate dehydrogenases (IDH) are important enzymes that catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG), producing NADPH in the process.	isocitric acid	101-111	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	27-30
27721426-5	2017	Both IDH2 and IDH1 (localized in the cytoplasm) proteins catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	99-109	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	5-9
27721426-5	2017	Both IDH2 and IDH1 (localized in the cytoplasm) proteins catalyze the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	99-109	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	14-18
28011762-2	2017	Cytosolic IDH1 converts isocitrate to alpha-ketoglutarate (alpha-KG), a key metabolite regulating nitrogen homeostasis in catabolic pathways.	isocitric acid	24-34	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	10-14
27460417-3	2016	Whereas IDHs convert isocitrate to alpha-ketoglutarate (alpha-KG) with simultaneous reduction of NADP(+) to NADPH, these IDH mutants reduce alpha-KG to D-2-hydroxyglutarate (D-2-HG) while oxidizing NADPH.	isocitric acid	21-31	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	8-11
27624942-2	2016	IDH1/2 normally catalyse the oxidative decarboxylation of isocitrate into alpha-ketoglutarate (alphaKG).	isocitric acid	58-68	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
27466503-1	2016	The isocitrate dehydrogenase (IDH) family of enzymes comprises of the key functional metabolic enzymes in the Krebs cycle that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	4-14	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	30-33
26782057-9	2016	These findings suggest that abnormality in the metabolism of isocitrate by IDH3A in the mitochondria plays a key role in the pathogenesis of BD, supporting the mitochondrial dysfunction hypothesis of BD.	isocitric acid	61-71	isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha	Homo sapiens	75-80
27621679-1	2016	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate.	isocitric acid	88-98	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	34-38
27621679-1	2016	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes that convert isocitrate to alpha-ketoglutarate.	isocitric acid	88-98	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	43-47
26819452-1	2016	IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma.	isocitric acid	70-80	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
27194485-1	2016	Arginine to histidine mutation at position 132 (R132H) in isocitrate dehydrogenase 1 (IDH1) led to reduced affinity of the respective enzymes for isocitrate and increased affinity for alpha-ketoglutarate (AKG) and NADPH.	isocitric acid	58-68	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	86-90
27049945-10	2016	Isotope tracing revealed that in spheroids, isocitrate/citrate produced reductively in the cytosol could enter the mitochondria and participate in oxidative metabolism, including oxidation by IDH2.	isocitric acid	44-54	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	192-196
26819452-1	2016	IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma.	isocitric acid	70-80	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
26819452-1	2016	IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma.	isocitric acid	70-80	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	200-204
26819452-1	2016	IDH1 and IDH2 are homodimeric enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate (alpha-KG) and concomitantly produce reduced NADPH from NADP(+) Mutations in the genes encoding IDH1 and IDH2 have recently been found in a variety of human cancers, most commonly glioma, acute myeloid leukemia (AML), chondrosarcoma, and intrahepatic cholangiocarcinoma.	isocitric acid	70-80	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	209-213
26188014-3	2016	IDH enzymes normally catalyze the decarboxylation of isocitrate to generate alpha-ketoglutarate (alphaKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of alphaKG into the putative oncometabolite D-2-hydroxyglutate (D2HG).	isocitric acid	53-63	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	146-150
26960449-4	2016	While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG).	isocitric acid	62-72	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	6-10
26960449-4	2016	While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG).	isocitric acid	62-72	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	15-19
26960449-4	2016	While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG).	isocitric acid	62-72	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	113-117
26960449-4	2016	While IDH1 and IDH2 catalyze the oxidative decarboxylation of isocitrate to form alpha-ketoglutarate (alpha-KG), IDH1 and IDH2 mutations convert alpha-KG to 2-hydroxyglutarate (2-HG).	isocitric acid	62-72	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	122-126
27005468-1	2016	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to alpha-ketoglutarate (alphaKG).IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).	isocitric acid	87-97	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	34-38
27005468-1	2016	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to alpha-ketoglutarate (alphaKG).IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).	isocitric acid	87-97	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	43-47
27005468-1	2016	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to alpha-ketoglutarate (alphaKG).IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).	isocitric acid	87-97	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	131-135
27005468-1	2016	Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) are key metabolic enzymes, converting isocitrate to alpha-ketoglutarate (alphaKG).IDH1 and IDH2 mutations have been identified in multiple tumor types, including gliomas and myeloid malignancies such as acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).	isocitric acid	87-97	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	140-144
27014635-3	2016	Wild-type IDH catalyzes the interconversion of isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	47-57	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	10-13
26755275-9	2016	Isocitrate is interconverted with citrate via the intermediate aconitate in a reaction catalyzed by the enzyme aconitase 1 (ACO1).	isocitric acid	0-10	aconitase 1	Homo sapiens	111-122
26755275-9	2016	Isocitrate is interconverted with citrate via the intermediate aconitate in a reaction catalyzed by the enzyme aconitase 1 (ACO1).	isocitric acid	0-10	aconitase 1	Homo sapiens	124-128
26603720-5	2016	Serum erythropoietin (EPO) levels were similar in treated versus control mice, indicating that isocitrate increased sensitivity to EPO.	isocitric acid	95-105	erythropoietin	Mus musculus	131-134
27292784-1	2016	Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	67-77	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
27292784-1	2016	Isocitrate dehydrogenase (IDH) is a metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG).	isocitric acid	67-77	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
26188014-3	2016	IDH enzymes normally catalyze the decarboxylation of isocitrate to generate alpha-ketoglutarate (alphaKG), but recurrent mutations at Arg(132) of IDH1 and Arg(172) of IDH2 confer a neomorphic enzyme activity that catalyzes reduction of alphaKG into the putative oncometabolite D-2-hydroxyglutate (D2HG).	isocitric acid	53-63	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	167-171
26589116-6	2015	IDH2-mediated conversion of isocitrate to alpha-ketoglutarate leads to the generation of NADPH, which is critical to buffering the H2O2 produced by the respiratory chain.	isocitric acid	28-38	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	0-4
26381180-2	2015	Although IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in cytosol, mutated IDH1 proteins possess the ability to change alpha-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG).	isocitric acid	55-65	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	9-13
26485760-3	2015	Isocitrate dehydrogenase (IDH) is a key factor in metabolism and catalyzes the oxidative decarboxylation of isocitrate.	isocitric acid	108-118	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
26485760-3	2015	Isocitrate dehydrogenase (IDH) is a key factor in metabolism and catalyzes the oxidative decarboxylation of isocitrate.	isocitric acid	108-118	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
25882048-1	2015	Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to alpha-ketoglutarate.	isocitric acid	101-111	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	0-26
25882048-1	2015	Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to alpha-ketoglutarate.	isocitric acid	101-111	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	28-32
25882048-1	2015	Isocitrate dehydrogenase-1 (Idh1) is an important metabolic enzyme that produces NADPH by converting isocitrate to alpha-ketoglutarate.	isocitric acid	101-111	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	81-86
26381180-2	2015	Although IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in cytosol, mutated IDH1 proteins possess the ability to change alpha-KG into the oncometabolite D-2-hydroxyglutarate (D-2HG).	isocitric acid	55-65	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	120-124
26590767-1	2015	Isocitrate dehydrogenase (IDH) catalyzes the conversion of isocitrate to alpha ketoglutarate.	isocitric acid	59-69	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
26204840-3	2015	The ICL catalyzes the conversion of isocitrate to succinate and glyoxylate in the glyoxylate bypass of the TCA cycle.	isocitric acid	36-46	isocitrate lyase	Bradyrhizobium diazoefficiens USDA 110	4-7
25774549-4	2015	However, rat islets exhibited a more pronounced glucose-provoked increase of glutamate, glycerol-3-phosphate, succinate, and lactate levels, whereas INS-1 832/13 cells showed a higher glucose-elicited increase in glucose-6-phosphate, alanine, isocitrate, and alpha-ketoglutarate levels.	isocitric acid	243-253	insulin 1	Rattus norvegicus	149-154
26590767-1	2015	Isocitrate dehydrogenase (IDH) catalyzes the conversion of isocitrate to alpha ketoglutarate.	isocitric acid	59-69	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
25634685-14	2015	Aconitate hydratase 2 (ACO2), which catalyzes the conversion of citrate to isocitrate in TCA cycle, was down-regulated in animals of the high-fat group (p < 0.05).	isocitric acid	75-85	aconitase 2	Homo sapiens	0-21
25733631-9	2015	RESULTS: A panel of 4 biomarkers-formate, citrulline, taurine, and isocitrate-were identified as markers of SSB intake.	isocitric acid	67-77	small RNA binding exonuclease protection factor La	Homo sapiens	108-111
26018518-1	2015	BACKGROUND: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield alpha-ketoglutarate (alpha-KG) with production of reduced nicotinamide adenine dinucleotide (NADH).	isocitric acid	86-96	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	12-36
26018518-1	2015	BACKGROUND: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield alpha-ketoglutarate (alpha-KG) with production of reduced nicotinamide adenine dinucleotide (NADH).	isocitric acid	86-96	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	38-41
25753205-2	2015	Although IDH2 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in mitochondria, mutated IDH2 proteins possess the ability to change alpha-KG into the oncometabolite R(-)-2-hydroxyglutarate (2-HG).	isocitric acid	55-65	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
25753205-2	2015	Although IDH2 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in mitochondria, mutated IDH2 proteins possess the ability to change alpha-KG into the oncometabolite R(-)-2-hydroxyglutarate (2-HG).	isocitric acid	55-65	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	125-129
25786174-5	2015	In M1 macrophages, we identified a metabolic break at Idh, the enzyme that converts isocitrate to alpha-ketoglutarate, providing mechanistic explanation for TCA cycle fragmentation.	isocitric acid	84-94	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	54-57
25853107-5	2015	RESULTS: We have found that IDH1, but not IDH1-R132H, can catalyze the conversion of isocitrate into alpha-ketoglutarate (alpha-KG).	isocitric acid	85-95	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
25634685-14	2015	Aconitate hydratase 2 (ACO2), which catalyzes the conversion of citrate to isocitrate in TCA cycle, was down-regulated in animals of the high-fat group (p < 0.05).	isocitric acid	75-85	aconitase 2	Homo sapiens	23-27
24980596-7	2014	An IDH1 heterodimer between wild-type and R132H mutant is capable of catalyzing conversion of alpha-KG to 2-HG and isocitrate to alpha-KG.	isocitric acid	115-125	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	3-7
25324168-3	2015	IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in the cytosol and mitochondria, respectively.	isocitric acid	54-64	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
25324168-3	2015	IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) in the cytosol and mitochondria, respectively.	isocitric acid	54-64	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
25218477-1	2014	Isocitrate dehydrogenase 1 (IDH1) is an evolutionarily conserved enzyme that catalyzes the interconversion of isocitrate to alpha-ketoglutarate with the concomitant reduction of NADP(+) to NADPH.	isocitric acid	110-120	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	0-26
25218477-1	2014	Isocitrate dehydrogenase 1 (IDH1) is an evolutionarily conserved enzyme that catalyzes the interconversion of isocitrate to alpha-ketoglutarate with the concomitant reduction of NADP(+) to NADPH.	isocitric acid	110-120	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	28-32
25706986-2	2015	IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate while mutant IDH1 catalyzes the conversion of alpha-ketoglutarate into 2-hydroxyglutarate.	isocitric acid	67-77	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
25706986-2	2015	IDH1 is the enzyme that catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate while mutant IDH1 catalyzes the conversion of alpha-ketoglutarate into 2-hydroxyglutarate.	isocitric acid	67-77	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	114-118
25502799-2	2014	Mutation of the catalytic Arg132 residue of human IDH1 (HcIDH) eliminates the enzyme"s wild-type isocitrate oxidation activity, but confer the mutant an ability of reducing alpha-ketoglutarate (alpha-KG) to 2-hydroxyglutarate (2-HG).	isocitric acid	97-107	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	50-54
24880135-5	2014	In their wild-type forms, IDH1 and IDH2 convert isocitrate and NADP(+) to alpha-ketoglutarate (alphaKG) and NADPH.	isocitric acid	48-58	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-30
24880135-5	2014	In their wild-type forms, IDH1 and IDH2 convert isocitrate and NADP(+) to alpha-ketoglutarate (alphaKG) and NADPH.	isocitric acid	48-58	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	35-39
25262187-0	2014	Fluorometric determination of free and total isocitrate in bovine milk.	isocitric acid	45-55	Weaning weight-maternal milk	Bos taurus	66-70
25262187-3	2014	This study describes a new analytical method for determination of free and total isocitrate in bovine milk where time-consuming pretreatment of the sample is not necessary.	isocitric acid	81-91	Weaning weight-maternal milk	Bos taurus	102-106
25262187-7	2014	Milk samples from Danish Holstein cows (984) contained significantly less isocitrate than milk from Danish Jersey cows (760; i.e., 0.134 vs. 0.211 mmol/L).	isocitric acid	74-84	Weaning weight-maternal milk	Bos taurus	0-4
25351951-4	2014	RESULTS: We found homozygous or compound heterozygous missense and frameshift mutations in the gene encoding mitochondrial aconitase (ACO2), a tricarboxylic acid cycle enzyme, catalysing interconversion of citrate into isocitrate.	isocitric acid	219-229	aconitase 2	Homo sapiens	109-132
25351951-4	2014	RESULTS: We found homozygous or compound heterozygous missense and frameshift mutations in the gene encoding mitochondrial aconitase (ACO2), a tricarboxylic acid cycle enzyme, catalysing interconversion of citrate into isocitrate.	isocitric acid	219-229	aconitase 2	Homo sapiens	134-138
23801081-1	2013	Isocitrate dehydrogenase 1 (IDH1) decarboxylates isocitrate to alpha-ketoglutarate (alpha-KG) leading to generation of NADPH, which is required to regenerate reduced glutathione (GSH), the major cellular ROS scavenger.	isocitric acid	49-59	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
24797066-4	2014	In IDH, the negatively charged C4-carboxylate of isocitrate stabilizes the ground state positive charge on the adjacent nicotinamide N1, opposing hydride transfer.	isocitric acid	49-59	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	3-6
24590270-1	2014	Isocitrate dehydrogenase 1 (IDH1), which localizes to the cytosol and peroxisomes, catalyzes the oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) and in parallel converts NADP(+) to NADPH.	isocitric acid	126-136	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
24616559-9	2014	Docking of isocitrate to both human IDHs and S. aureus IDH structures showed docking scores of -11.6169 and -10.973 respectively clearly indicating higher binding affinity of isocitrate to human IDH.	isocitric acid	11-21	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	36-39
24616559-9	2014	Docking of isocitrate to both human IDHs and S. aureus IDH structures showed docking scores of -11.6169 and -10.973 respectively clearly indicating higher binding affinity of isocitrate to human IDH.	isocitric acid	11-21	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	55-58
24616559-9	2014	Docking of isocitrate to both human IDHs and S. aureus IDH structures showed docking scores of -11.6169 and -10.973 respectively clearly indicating higher binding affinity of isocitrate to human IDH.	isocitric acid	175-185	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	36-39
24616559-9	2014	Docking of isocitrate to both human IDHs and S. aureus IDH structures showed docking scores of -11.6169 and -10.973 respectively clearly indicating higher binding affinity of isocitrate to human IDH.	isocitric acid	175-185	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	55-58
23801081-1	2013	Isocitrate dehydrogenase 1 (IDH1) decarboxylates isocitrate to alpha-ketoglutarate (alpha-KG) leading to generation of NADPH, which is required to regenerate reduced glutathione (GSH), the major cellular ROS scavenger.	isocitric acid	49-59	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
23847760-2	2013	IDH1/2 mutations prevent oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) and modulate the function of IDH (neomorphic activity) thereby facilitating reduction of alpha-KG to D-2-hydroxyglutarate (D-2HG), a putative oncometabolite.	isocitric acid	54-64	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-6
23731180-1	2013	The human, cytosolic enzyme isocitrate dehydrogenase 1 (IDH1) reversibly converts isocitrate to alpha-ketoglutarate (alphaKG).	isocitric acid	28-38	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	56-60
23731180-8	2013	We propose that the sum of these kinetic changes allows the mutant IDH1 enzymes to reductively trap alphaKG directly into 2HG, rather than allowing it to react with carbon dioxide and form isocitrate, as occurs in the wild-type enzyme.	isocitric acid	189-199	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	67-71
23847760-2	2013	IDH1/2 mutations prevent oxidative decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG) and modulate the function of IDH (neomorphic activity) thereby facilitating reduction of alpha-KG to D-2-hydroxyglutarate (D-2HG), a putative oncometabolite.	isocitric acid	54-64	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3
23232569-2	2013	Mutant IDH enzyme loses its normal activity to convert isocitrate into alpha-ketoglutarate (alphaKG) and instead acquires the ability to reduce alphaKG to D-2-hydroxyglutarate.	isocitric acid	55-65	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	7-10
23709747-3	2013	Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate.	isocitric acid	164-174	aconitase 2	Homo sapiens	0-23
23709747-3	2013	Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for the interconversion of citrate to isocitrate as part of the citric acid cycle in the human prostate.	isocitric acid	164-174	aconitase 2	Homo sapiens	33-38
23750482-1	2013	Isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate in cytosol.	isocitric acid	75-85	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	0-26
23750482-1	2013	Isocitrate dehydrogenase 1 (IDH1) catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate in cytosol.	isocitric acid	75-85	isocitrate dehydrogenase (NADP(+)) 1	Rattus norvegicus	28-32
23410661-8	2013	Increased 2-hydroxyglutarate/isocitrate ratios were seen in patients with IDH1-mutated LGG and sGBM, in comparison with those with IDH1-nonmutated LGG, pGBM, and nonglioma groups.	isocitric acid	29-39	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	74-78
23782684-3	2013	Although IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to alpha-ketoglutarate in cytosol and mitochondria, respectively, mutated IDH1/2 proteins can possess the ability to change alpha-ketoglutarate to an oncometabolite R(-)-2-hydroxyglutarate.	isocitric acid	63-73	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	9-13
23782684-3	2013	Although IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to alpha-ketoglutarate in cytosol and mitochondria, respectively, mutated IDH1/2 proteins can possess the ability to change alpha-ketoglutarate to an oncometabolite R(-)-2-hydroxyglutarate.	isocitric acid	63-73	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	18-22
23782684-3	2013	Although IDH1 and IDH2 catalyze the oxidative carboxylation of isocitrate to alpha-ketoglutarate in cytosol and mitochondria, respectively, mutated IDH1/2 proteins can possess the ability to change alpha-ketoglutarate to an oncometabolite R(-)-2-hydroxyglutarate.	isocitric acid	63-73	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	148-154
23630074-2	2013	IDH1 and IDH2 catalyze the interconversion of isocitrate and 2-oxoglutarate (2OG).	isocitric acid	46-56	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
23630074-2	2013	IDH1 and IDH2 catalyze the interconversion of isocitrate and 2-oxoglutarate (2OG).	isocitric acid	46-56	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
23550275-2	2013	Aconitase (ACO2) is an essential enzyme located in the mitochondria and catalyzes the interconversion of citrate and isocitrate in the tricarboxylic acid cycle.	isocitric acid	117-127	aconitase 2	Homo sapiens	11-15
23485467-2	2013	While IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate in cytosol, mutated IDH1 proteins possess the ability to change alpha-ketoglutarate into onco-metabolite R(-)-2-hydroxyglutarate (2-HG).	isocitric acid	52-62	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	6-10
23485467-2	2013	While IDH1 catalyzes the oxidative carboxylation of isocitrate to alpha-ketoglutarate in cytosol, mutated IDH1 proteins possess the ability to change alpha-ketoglutarate into onco-metabolite R(-)-2-hydroxyglutarate (2-HG).	isocitric acid	52-62	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	106-110
24066190-1	2013	Aconitase, the second enzyme of the tricarboxylic acid cycle encoded by ACO1 in the budding yeast Saccharomyces cerevisiae, catalyzes the conversion of citrate to isocitrate.	isocitric acid	163-173	aconitate hydratase ACO1	Saccharomyces cerevisiae S288C	72-76
22533343-1	2012	Isocitrate dehydrogenase 1 (IDH1), a cytosolic enzyme that converts isocitrate to alpha-ketoglutarate, has been shown to be dysregulated during tumorigenesis.	isocitric acid	68-78	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
24077277-1	2013	Cytosolic isocitrate dehydrogenase 1 (IDH1) with an R132H mutation in brain tumors loses its enzymatic activity for catalyzing isocitrate to alpha-ketoglutarate (alpha-KG) and acquires new activity whereby it converts alpha-KG to 2-hydroxyglutarate.	isocitric acid	10-20	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	38-42
23226729-1	2012	IDH2 encodes a mitochondrial metabolic enzyme that converts isocitrate to alpha-ketoglutarate (alpha-KG) by reducing nicotinamide adenine dinucleotide phosphate (NADP(+)) to NADPH and participates in the citric acid cycle for energy production.	isocitric acid	60-70	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	0-4
22533343-1	2012	Isocitrate dehydrogenase 1 (IDH1), a cytosolic enzyme that converts isocitrate to alpha-ketoglutarate, has been shown to be dysregulated during tumorigenesis.	isocitric acid	68-78	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
21996744-5	2012	In contrast, we find that the IDH1 SNPs V71I and V178I, as well as a number of other single-sample reports of IDH non-synonymous mutation, did not elevate cellular 2HG levels in cells and retained the wild-type ability for isocitrate-dependent NADPH production.	isocitric acid	223-233	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	30-34
22106302-6	2011	Glutamine-derived alpha-ketoglutarate is reductively carboxylated by the NADPH-linked mitochondrial isocitrate dehydrogenase (IDH2) to form isocitrate, which can then be isomerized to citrate.	isocitric acid	100-110	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	126-130
22442146-1	2012	Isocitrate dehydrogenase (IDH) is a reversible enzyme that catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) and the NADPH/CO(2)-dependent reductive carboxylation of alphaKG to ICT.	isocitric acid	120-130	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
22442146-1	2012	Isocitrate dehydrogenase (IDH) is a reversible enzyme that catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) and the NADPH/CO(2)-dependent reductive carboxylation of alphaKG to ICT.	isocitric acid	120-130	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
22442146-1	2012	Isocitrate dehydrogenase (IDH) is a reversible enzyme that catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (ICT) to alpha-ketoglutarate (alphaKG) and the NADPH/CO(2)-dependent reductive carboxylation of alphaKG to ICT.	isocitric acid	120-130	2,4-dienoyl-CoA reductase 1	Homo sapiens	178-183
22442146-2	2012	Reductive carboxylation by IDH1 was potently inhibited by NADP(+) and, to a lesser extent, by ICT.	isocitric acid	94-97	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	27-31
22008468-2	2012	IDH2 contains catalytic isocitrate/Mg2+ and NAD+ binding sites whereas IDH1 contains homologous binding sites, respectively, for cooperative binding of isocitrate and for allosteric binding of AMP.	isocitric acid	24-34	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	0-4
22008468-2	2012	IDH2 contains catalytic isocitrate/Mg2+ and NAD+ binding sites whereas IDH1 contains homologous binding sites, respectively, for cooperative binding of isocitrate and for allosteric binding of AMP.	isocitric acid	152-162	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	0-4
22008468-2	2012	IDH2 contains catalytic isocitrate/Mg2+ and NAD+ binding sites whereas IDH1 contains homologous binding sites, respectively, for cooperative binding of isocitrate and for allosteric binding of AMP.	isocitric acid	152-162	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	71-75
22397365-1	2012	BACKGROUND: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate.	isocitric acid	152-162	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	46-50
22397365-1	2012	BACKGROUND: Isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes encode cytosolic and mitochondrial enzymes that catalyze the conversion of isocitrate to alpha-ketoglutarate.	isocitric acid	152-162	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	55-59
22385606-1	2012	Isocitrate dehydrogenase (IDH) encodes a nicotinamide adenine dinucleotide phosphate+-dependent enzyme for oxidative decarboxylation of isocitrate and has an essential role in the tricarboxylic acid cycle.	isocitric acid	136-146	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-24
22385606-1	2012	Isocitrate dehydrogenase (IDH) encodes a nicotinamide adenine dinucleotide phosphate+-dependent enzyme for oxidative decarboxylation of isocitrate and has an essential role in the tricarboxylic acid cycle.	isocitric acid	136-146	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-29
22343896-4	2012	IDH1 and IDH2, which catalyse the interconversion of isocitrate and 2-OG, are frequently mutated in human brain tumours and leukaemias.	isocitric acid	53-63	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
22343896-4	2012	IDH1 and IDH2, which catalyse the interconversion of isocitrate and 2-OG, are frequently mutated in human brain tumours and leukaemias.	isocitric acid	53-63	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	9-13
22147457-1	2011	The NADP+-dependent isocitrate dehydrogenases 1 and 2 (IDH1/2) catalyze the oxidative decarboxylation of isocitrate into alpha-ketoglutarate (alpha-KG).	isocitric acid	20-30	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	55-61
21885076-3	2011	IDH1 encodes the cytoplasmic NADP dependent isocitrate dehydrogenase1 that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate.	isocitric acid	44-54	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
21647154-5	2011	Structural modeling of IDH2 suggested that codon 140 mutations disrupt the enzyme"s ability to bind its substrate isocitrate.	isocitric acid	114-124	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	23-27
21647154-6	2011	Accordingly, recombinant IDH2 R140Q/W were unable to carry out the decarboxylation of isocitrate to alpha-ketoglutarate (alpha-KG), but instead gained the neomorphic activity to reduce alpha-KG to R(-)-2-hydroxyglutarete (2-HG).	isocitric acid	86-96	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	25-29
21889589-2	2011	Overexpression studies with IDH1(R132H) and IDH2(R172K) mutations demonstrated that the enzymes acquired a new function, converting 2-ketoglutarate (2-KG) to d-2-hydroxyglutarate (D-2-HG), in lieu of the normal IDH reaction which reversibly converts isocitrate to 2-KG.	isocitric acid	250-260	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
21889589-2	2011	Overexpression studies with IDH1(R132H) and IDH2(R172K) mutations demonstrated that the enzymes acquired a new function, converting 2-ketoglutarate (2-KG) to d-2-hydroxyglutarate (D-2-HG), in lieu of the normal IDH reaction which reversibly converts isocitrate to 2-KG.	isocitric acid	250-260	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	44-48
20972461-3	2010	Soon, it became clear that the mutations identified impaired the ability of IDH1 and IDH2 to catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG), whereas conferring a gain of a novel enzymatic activity leading to the reduction of alphaKG to the metabolite D2-hydroxyglutarate (D-2HG).	isocitric acid	120-130	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	76-80
22040412-1	2011	BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of alpha-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway.	isocitric acid	70-80	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	98-102
22040412-1	2011	BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of alpha-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway.	isocitric acid	70-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	257-283
22040412-1	2011	BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of alpha-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway.	isocitric acid	70-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	285-290
22040412-1	2011	BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of alpha-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway.	isocitric acid	134-137	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	70-96
22040412-1	2011	BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of alpha-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway.	isocitric acid	134-137	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	98-102
22040412-1	2011	BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of alpha-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway.	isocitric acid	134-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	257-283
22040412-1	2011	BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of alpha-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway.	isocitric acid	134-137	hypoxia inducible factor 1 subunit alpha	Homo sapiens	285-290
20949348-10	2011	CONCLUSIONS/INTERPRETATION: Malate transport by DIC may play an important role in GSIS, possibly by providing cytosolic malate as a counter-substrate for citrate and/or isocitrate export by CIC.	isocitric acid	169-179	solute carrier family 25 member 10	Rattus norvegicus	48-51
21861471-6	2011	A tetrameric form of IDH (an IDH1(G15D)/IDH2 mutant enzyme) demonstrated half-site binding for isocitrate (two sites) in the absence of dithiothreitol and full-site binding (four sites) in the presence of dithiothreitol.	isocitric acid	95-105	isocitrate dehydrogenase (NAD(+)) IDH1	Saccharomyces cerevisiae S288C	29-33
21861471-6	2011	A tetrameric form of IDH (an IDH1(G15D)/IDH2 mutant enzyme) demonstrated half-site binding for isocitrate (two sites) in the absence of dithiothreitol and full-site binding (four sites) in the presence of dithiothreitol.	isocitric acid	95-105	isocitrate dehydrogenase (NAD(+)) IDH2	Saccharomyces cerevisiae S288C	40-44
20972461-3	2010	Soon, it became clear that the mutations identified impaired the ability of IDH1 and IDH2 to catalyze the conversion of isocitrate to alpha-ketoglutarate (alphaKG), whereas conferring a gain of a novel enzymatic activity leading to the reduction of alphaKG to the metabolite D2-hydroxyglutarate (D-2HG).	isocitric acid	120-130	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	85-89
20619351-6	2010	These studies are based upon predicted interaction sites of isocitrate lyase (ICL) and isocitrate.	isocitric acid	60-70	LOW QUALITY PROTEIN: isocitrate lyase	Brassica oleracea	78-81
20975740-4	2010	Here, we report the structures of the R132H mutant IDH1 with and without isocitrate (ICT) bound.	isocitric acid	73-83	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	51-55
20975740-4	2010	Here, we report the structures of the R132H mutant IDH1 with and without isocitrate (ICT) bound.	isocitric acid	85-88	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	51-55
20866109-2	2010	Intracellular free [Mg2+] can be estimated by measurements of [citrate]/[isocitrate], a ratio known to vary with tissue free [Mg2+].	isocitric acid	73-83	mucin 7, secreted	Homo sapiens	20-23
20866109-2	2010	Intracellular free [Mg2+] can be estimated by measurements of [citrate]/[isocitrate], a ratio known to vary with tissue free [Mg2+].	isocitric acid	73-83	mucin 7, secreted	Homo sapiens	126-129
20619351-7	2010	Inhibition of isocitrate binding to ICL is demonstrated to prevent rescue of glyoxylate cycle that is essential for metabolism of L. maculans in B. oleracea.	isocitric acid	14-24	LOW QUALITY PROTEIN: isocitrate lyase	Brassica oleracea	36-39
20603105-1	2010	Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH).	isocitric acid	38-48	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
20692206-1	2010	The systematic sequencing of glioblastoma multiforme (GBM) genomes has identified the recurrent mutation of IDH1, a gene encoding NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) that catalyzes the oxidative decarboxylation of isocitrate yielding alpha-ketoglutarate (alpha-KG).	isocitric acid	148-158	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	108-112
20692206-1	2010	The systematic sequencing of glioblastoma multiforme (GBM) genomes has identified the recurrent mutation of IDH1, a gene encoding NADP(+)-dependent isocitrate dehydrogenase 1 (IDH1) that catalyzes the oxidative decarboxylation of isocitrate yielding alpha-ketoglutarate (alpha-KG).	isocitric acid	148-158	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	176-180
20603105-1	2010	Isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are enzymes which convert isocitrate to alpha-ketoglutarate while reducing nicotinamide adenine dinucleotide phosphate (NADP+to NADPH).	isocitric acid	38-48	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	66-70
20510884-2	2010	Heterozygous mutations in the IDH1 occur in the majority of grade II and grade III gliomas and secondary glioblastomas and change the structure of the enzyme, which diminishes its ability to convert isocitrate (ICT) to alpha-ketoglutarate (alpha-KG) and provides it with a newly acquired ability to convert alpha-KG to R(-)-2-hydroxyglutarate [R(-)-2HG].	isocitric acid	199-209	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	30-34
20356834-7	2010	These data reveal that the OGC is part of a mechanism of fuel-stimulated insulin secretion that is common to glucose, amino acid, and organic acid secretagogues, involving flux through the pyruvate/isocitrate cycling pathway.	isocitric acid	198-208	solute carrier family 25 member 11	Rattus norvegicus	27-30