PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9467825-5	1997	Alterations in kinetic parameters of G6Pase were calculated in both intact and detergent-treated microsomes, using glucose-6-phosphate and pyrophosphate as substrate.	Glucose-6-Phosphate	115-134	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	37-43
9341134-1	1997	Glucose-6-phosphatase (G6Pase) catalyzes the hydrolysis of glucose 6-phosphate (Glu-6-P) to free glucose and, as the last step in gluconeogenesis and glycogenolysis in liver, is thought to play an important role in glucose homeostasis.	Glucose-6-Phosphate	59-78	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
9341134-1	1997	Glucose-6-phosphatase (G6Pase) catalyzes the hydrolysis of glucose 6-phosphate (Glu-6-P) to free glucose and, as the last step in gluconeogenesis and glycogenolysis in liver, is thought to play an important role in glucose homeostasis.	Glucose-6-Phosphate	59-78	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	23-29
9341134-1	1997	Glucose-6-phosphatase (G6Pase) catalyzes the hydrolysis of glucose 6-phosphate (Glu-6-P) to free glucose and, as the last step in gluconeogenesis and glycogenolysis in liver, is thought to play an important role in glucose homeostasis.	Glucose-6-Phosphate	80-87	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
9341134-1	1997	Glucose-6-phosphatase (G6Pase) catalyzes the hydrolysis of glucose 6-phosphate (Glu-6-P) to free glucose and, as the last step in gluconeogenesis and glycogenolysis in liver, is thought to play an important role in glucose homeostasis.	Glucose-6-Phosphate	80-87	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	23-29
9341134-4	1997	We found that AdCMV-G6Pase-treated liver cells contain significantly less glycogen and Glu-6-P, but unchanged UDP-glucose levels, relative to control cells.	Glucose-6-Phosphate	87-94	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	20-26
9341134-5	1997	Further, the glycogen synthase activity state was closely correlated with Glu-6-P levels over a wide range of glucose concentrations in both G6Pase-overexpressing and control cells.	Glucose-6-Phosphate	74-81	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	141-147
9341134-6	1997	The reduction in glycogen synthesis in AdCMV-G6Pase-treated hepatocytes is therefore not a function of decreased substrate availability but rather occurs because of the regulatory effects of Glu-6-P on glycogen synthase activity.	Glucose-6-Phosphate	191-198	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	45-51
9341134-7	1997	We also found that AdCMV-G6Pase-treated-cells had significantly lower rates of lactate production and [3-3H]glucose usage, coupled with enhanced rates of gluconeogenesis and Glu-6-P hydrolysis.	Glucose-6-Phosphate	174-181	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	25-31
9392523-4	1997	G6PDH showed a gradual decrease in Vmax and Km for glucose-6-phosphate in extralesional normal-looking liver tissue.	Glucose-6-Phosphate	51-70	glucose-6-phosphate dehydrogenase	Homo sapiens	0-5
9325299-7	1997	In summary, in insulinoma beta cells strongly overexpressing glucokinase, an imbalance between glucose phosphorylation and turnover of glucose 6-phosphate resulted in acute glucose intolerance due to trapping of cellular orthophosphate in dead-end product and severe paralysis of energy metabolism.	Glucose-6-Phosphate	135-154	glucokinase	Rattus norvegicus	61-72
9312082-2	1997	Glucose-6-phosphatase (Glu-6-Pase) catalyzes the terminal step of gluconeogenesis, the conversion of glucose 6-phosphate (Glu-6-P) to free glucose.	Glucose-6-Phosphate	101-120	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	0-21
9312082-2	1997	Glucose-6-phosphatase (Glu-6-Pase) catalyzes the terminal step of gluconeogenesis, the conversion of glucose 6-phosphate (Glu-6-P) to free glucose.	Glucose-6-Phosphate	101-120	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	23-33
9312082-2	1997	Glucose-6-phosphatase (Glu-6-Pase) catalyzes the terminal step of gluconeogenesis, the conversion of glucose 6-phosphate (Glu-6-P) to free glucose.	Glucose-6-Phosphate	23-30	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	0-21
9281318-9	1997	Fusion proteins including the N-terminal half of Type I hexokinase became dissociated from mitochondria under conditions favorable for accumulation of intracellular Glc-6-P.	Glucose-6-Phosphate	165-172	hexokinase 1	Homo sapiens	56-66
9316430-8	1997	We conclude that 1) beta-adrenergic stimulation decreases glucose uptake by raising glucose 6-phosphate concentration, thus inhibiting hexokinase, but does not inhibit insulin-stimulated glucose transport and 2) phosphorylation of GLUT-4 has no effect on glucose transport in skeletal muscle.	Glucose-6-Phosphate	84-103	solute carrier family 2 member 4	Rattus norvegicus	231-237
9245738-1	1997	We show that the production of glucose from glucose-6-phosphate hydrolysis outside microsomes is a function of glucose-6-phosphatase independent of its property to form glucose inside microsomes.	Glucose-6-Phosphate	44-63	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	111-132
9291103-7	1997	Among the various glucose metabolites measured, glucose 6-phosphate, in contrast with xylulose 5-phosphate and metabolites of the lower part of glycolysis, is the only one that shows a clear-cut parallelism between its concentration and the degree of S14 and FAS gene expression.	Glucose-6-Phosphate	48-67	thyroid hormone responsive	Rattus norvegicus	251-254
9291103-7	1997	Among the various glucose metabolites measured, glucose 6-phosphate, in contrast with xylulose 5-phosphate and metabolites of the lower part of glycolysis, is the only one that shows a clear-cut parallelism between its concentration and the degree of S14 and FAS gene expression.	Glucose-6-Phosphate	48-67	fatty acid synthase	Rattus norvegicus	259-262
9291103-0	1997	Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations.	Glucose-6-Phosphate	153-172	fatty acid synthase	Rattus norvegicus	13-32
9291103-0	1997	Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations.	Glucose-6-Phosphate	153-172	thyroid hormone responsive	Rattus norvegicus	37-40
9271087-9	1997	The glucose 6-phosphate content correlated with the free glucokinase activity.	Glucose-6-Phosphate	4-23	glucokinase	Homo sapiens	57-68
9271087-11	1997	The suppression of glucose 6-phosphate at high glucose concentration (15-35 mM) could be explained by the low activity of free glucokinase.	Glucose-6-Phosphate	19-38	glucokinase	Homo sapiens	127-138
9195881-3	1997	The existence of an anionic binding site near the NADP+ has been determined from the structures of the complexes of AR with citrate, cacodylate and glucose-6-phosphate.	Glucose-6-Phosphate	148-167	aldo-keto reductase family 1 member B	Homo sapiens	116-118
9153206-5	1997	The relative size of the intravesicular glucose-6-phosphate pool (irrespective of the concentration of the extravesicular concentration of added glucose-6-phosphate) expressed as the apparent intravesicular space of the hexose phosphate was inversely dependent on glucose-6-phosphatase activity.	Glucose-6-Phosphate	40-59	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	264-285
9153206-9	1997	It is concluded that liver microsomes take up glucose-6-phosphate, constituting a pool directly accessible to intraluminal glucose-6-phosphatase activity.	Glucose-6-Phosphate	46-65	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	123-144
9218418-5	1997	The expression of the L-PK gene in GLUT 2(-) cells cultured in the absence of glucose was correlated with a high intracellular glucose 6-phosphate (Glu-6-P) concentration while under similar culture conditions Glu-6-P concentration was very low in GLUT 2(+) cells.	Glucose-6-Phosphate	127-146	pyruvate kinase liver and red blood cell	Mus musculus	22-26
9218418-5	1997	The expression of the L-PK gene in GLUT 2(-) cells cultured in the absence of glucose was correlated with a high intracellular glucose 6-phosphate (Glu-6-P) concentration while under similar culture conditions Glu-6-P concentration was very low in GLUT 2(+) cells.	Glucose-6-Phosphate	127-146	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	35-41
9218418-5	1997	The expression of the L-PK gene in GLUT 2(-) cells cultured in the absence of glucose was correlated with a high intracellular glucose 6-phosphate (Glu-6-P) concentration while under similar culture conditions Glu-6-P concentration was very low in GLUT 2(+) cells.	Glucose-6-Phosphate	148-155	pyruvate kinase liver and red blood cell	Mus musculus	22-26
9218418-5	1997	The expression of the L-PK gene in GLUT 2(-) cells cultured in the absence of glucose was correlated with a high intracellular glucose 6-phosphate (Glu-6-P) concentration while under similar culture conditions Glu-6-P concentration was very low in GLUT 2(+) cells.	Glucose-6-Phosphate	148-155	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	35-41
9218418-5	1997	The expression of the L-PK gene in GLUT 2(-) cells cultured in the absence of glucose was correlated with a high intracellular glucose 6-phosphate (Glu-6-P) concentration while under similar culture conditions Glu-6-P concentration was very low in GLUT 2(+) cells.	Glucose-6-Phosphate	210-217	pyruvate kinase liver and red blood cell	Mus musculus	22-26
9218418-5	1997	The expression of the L-PK gene in GLUT 2(-) cells cultured in the absence of glucose was correlated with a high intracellular glucose 6-phosphate (Glu-6-P) concentration while under similar culture conditions Glu-6-P concentration was very low in GLUT 2(+) cells.	Glucose-6-Phosphate	210-217	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	35-41
9218418-6	1997	Consequently, a role of GLUT 2 in the glucose responsiveness of glucose-sensitive genes in cultured hepatoma cells could be to allow for Glu-6-P depletion under gluconeogenic culture conditions.	Glucose-6-Phosphate	137-144	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	24-30
9218418-7	1997	In the absence of GLUT 2, glucose endogeneously produced might be unable to be exported from the cells and would be phosphorylated again to Glu-6-P by constitutively expressed hexokinase isoforms, continuously generating the glycolytic intermediates active on the L-PK gene transcription.	Glucose-6-Phosphate	140-147	pyruvate kinase liver and red blood cell	Mus musculus	264-268
9211349-4	1997	Glucose 6-phosphate inhibited VDR binding to the osteocalcin VDRE and chemically modified the DNA binding domain or the dimerization domain of the VDR in vitro.	Glucose-6-Phosphate	0-19	vitamin D receptor	Rattus norvegicus	30-33
9211349-4	1997	Glucose 6-phosphate inhibited VDR binding to the osteocalcin VDRE and chemically modified the DNA binding domain or the dimerization domain of the VDR in vitro.	Glucose-6-Phosphate	0-19	bone gamma-carboxyglutamate protein	Rattus norvegicus	49-60
9211349-4	1997	Glucose 6-phosphate inhibited VDR binding to the osteocalcin VDRE and chemically modified the DNA binding domain or the dimerization domain of the VDR in vitro.	Glucose-6-Phosphate	0-19	vitamin D receptor	Rattus norvegicus	61-64
9193882-7	1997	Activity was measured by following DAK-dependent oxygen uptake polarographically at 37 degrees C in pyrophosphate buffer (pH 8.8) containing the glucose-6-phosphate NADPH-generating system.	Glucose-6-Phosphate	145-164	triokinase and FMN cyclase	Rattus norvegicus	35-38
9378521-3	1997	Increase and decrease in activity of hexokinase and phosphoglucoisomerase respectively will increase the cytosolic glucose-6 phosphate content.	Glucose-6-Phosphate	115-134	hexokinase 1	Homo sapiens	37-47
9209706-5	1997	The role of Glut2 can be to enhance the depletion of gluconeogenic cells into glucose-6-phosphate (G6-P) when cultivated without glucose.	Glucose-6-Phosphate	78-97	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	12-17
9194712-11	1997	These results, combined with the fact that both the cAMP and the CRP levels are lowered by glucose 6-phosphate, lactose and gluconate, lead to the conclusion that the decreased cAMP and CRP levels are the cause of catabolite repression by these non-PTS carbon sources.	Glucose-6-Phosphate	91-110	catabolite gene activator protein	Escherichia coli	65-68
9194712-11	1997	These results, combined with the fact that both the cAMP and the CRP levels are lowered by glucose 6-phosphate, lactose and gluconate, lead to the conclusion that the decreased cAMP and CRP levels are the cause of catabolite repression by these non-PTS carbon sources.	Glucose-6-Phosphate	91-110	catabolite gene activator protein	Escherichia coli	186-189
9048897-0	1997	Desensitization to glucose 6-phosphate of phosphoenolpyruvate carboxylase from maize leaves by pyridoxal 5"-phosphate.	Glucose-6-Phosphate	19-38	MLO-like protein 4	Zea mays	42-73
9209706-5	1997	The role of Glut2 can be to enhance the depletion of gluconeogenic cells into glucose-6-phosphate (G6-P) when cultivated without glucose.	Glucose-6-Phosphate	99-103	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	12-17
9068797-2	1997	We demonstrate that: (1) neuronal and glial cells take up alpha-(L)-iduronidase released into the medium by retrovirally transduced fibroblasts expressing high levels of alpha-(L)-iduronidase; (2) both glial and neuronal cells express the cation independent mannose-6-phosphate receptor responsible for lysosomal enzyme uptake; and (3) uptake of the lysosomal enzyme can be blocked by excess free mannose-6-phosphate, but not glucose-6-phosphate.	Glucose-6-Phosphate	426-445	alpha-L-iduronidase	Homo sapiens	58-79
9259992-4	1997	Incubation of LDL with glucose or glucose-6-phosphate produces AGE moieties on both the lipid and apolipoprotein B components.	Glucose-6-Phosphate	34-53	apolipoprotein B	Bos taurus	98-114
9038862-8	1997	The changes in fractional activity of GS and in activity ratio of GP were inversely related (r = - 0.68, P < 0.05), G-6-P concentration was decreased during insulin stimulation compared with basal (P = 0.01).	Glucose-6-Phosphate	119-124	insulin	Macaca mulatta	160-167
9068797-2	1997	We demonstrate that: (1) neuronal and glial cells take up alpha-(L)-iduronidase released into the medium by retrovirally transduced fibroblasts expressing high levels of alpha-(L)-iduronidase; (2) both glial and neuronal cells express the cation independent mannose-6-phosphate receptor responsible for lysosomal enzyme uptake; and (3) uptake of the lysosomal enzyme can be blocked by excess free mannose-6-phosphate, but not glucose-6-phosphate.	Glucose-6-Phosphate	426-445	alpha-L-iduronidase	Homo sapiens	170-191
8936600-7	1996	In accord with a previous report, the S. mansoni hexokinase exhibited moderate sensitivity to inhibition (competitive vs ATP) by the product, glucose 6-phosphate, with a Ki approximately 150 microM; the product analog, 1,5-anhydroglucitol 6-phosphate, was somewhat less effective as an inhibitor, with Ki approximately 500 microM.	Glucose-6-Phosphate	142-161	hexokinase	Schistosoma mansoni	49-59
9344975-7	1997	As in the case of mammalian muscle, glucose 6-phosphate is a potent inhibitor of hexokinase in eel cardiac muscle (IC50=0.44 mmol l-1).	Glucose-6-Phosphate	36-55	hexokinase 1	Homo sapiens	81-91
8751724-4	1996	This activation of GK led to an increase in the intracellular concentration of glucose 6-phosphate, which was also related to an induction of glycogen accumulation.	Glucose-6-Phosphate	79-98	glucokinase	Mus musculus	19-21
8902199-4	1996	Two separate measurements of hexokinase activity were made on each muscle homogenate: the total hexokinase activity (glucose 6-phosphate was metabolized immediately by glucose 6-phosphate dehydrogenase) and the fractional hexokinase activity (glucose 6-phosphate accumulated so as to regulate the enzyme as in vivo).	Glucose-6-Phosphate	117-136	glucose-6-phosphate dehydrogenase	Rattus norvegicus	168-201
8798601-0	1996	Glucose 6-phosphate produced by glucokinase, but not hexokinase I, promotes the activation of hepatic glycogen synthase.	Glucose-6-Phosphate	0-19	glucokinase	Homo sapiens	32-43
8798601-10	1996	We conclude that Glu-6-P produced by overexpressed glucokinase is glycogenic because it effectively promotes activation of glycogen synthase.	Glucose-6-Phosphate	17-24	glucokinase	Homo sapiens	51-62
8798601-11	1996	Glu-6-P produced by overexpressed hexokinase, in contrast, appears to be unable to exert the same regulatory effects, probably due to the different subcellular distribution of the two glucose-phosphorylating enzymes.	Glucose-6-Phosphate	0-7	hexokinase 1	Homo sapiens	34-44
9219438-3	1996	The kinetics of brain glucose-6-phosphate dehydrogenase are compatible with a model involving two possible states of the enzyme with a low and high affinity for the substrate D-glucose-6-phosphate.	Glucose-6-Phosphate	175-196	glucose-6-phosphate dehydrogenase	Rattus norvegicus	22-55
8930135-4	1996	Glucokinase activity also was documented in the cross-linked and permeabilized islets, it being less sensitive than hexokinase activity to inhibition by D-glucose-6-phosphate.	Glucose-6-Phosphate	153-174	glucokinase	Rattus norvegicus	0-11
8787686-4	1996	Determination of GS kinetic constants from muscle cells of NIDDM revealed an increased basal and insulin-stimulated Km(0.1) for UDP-glucose, a decreased insulin-stimulated Vmax(0.1) and an increased insulin-stimulated activation constant (A(0.5)) for glucose-6-phosphate.	Glucose-6-Phosphate	251-270	insulin	Homo sapiens	97-104
8984999-1	1996	The kinetics of glucose 6-phosphate oxidation by glucose 6-phosphate dehydrogenase from wheat seeds was studied at pH 6-11 within a broad interval of the glucose 6-phosphate and NADH concentrations.	Glucose-6-Phosphate	16-35	glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform	Triticum aestivum	49-82
8674049-4	1996	PHI catalyzes isomerization of glucose 6-phosphate to fructose 6-phosphate and is specific for both sugars.	Glucose-6-Phosphate	31-50	glucose-6-phosphate isomerase 1	Mus musculus	0-3
8692973-6	1996	In contrast to nontransgenic mice treated with streptozotocin, mice with the transgene previously treated with streptozotocin showed high levels of both glucokinase mRNA and its enzyme activity in the liver, which were associated with an increase in intracellular levels of glucose 6-phosphate and glycogen.	Glucose-6-Phosphate	274-293	glucokinase	Mus musculus	153-164
8662949-5	1996	The replacement of region 2 of HKII-C by the corresponding region of glucokinase increased the affinity for glucose and decreased the affinity for Glc-6-P, but it did not significantly affect the affinity for ATP.	Glucose-6-Phosphate	147-154	hexokinase 2	Rattus norvegicus	31-35
8662949-5	1996	The replacement of region 2 of HKII-C by the corresponding region of glucokinase increased the affinity for glucose and decreased the affinity for Glc-6-P, but it did not significantly affect the affinity for ATP.	Glucose-6-Phosphate	147-154	glucokinase	Rattus norvegicus	69-80
8679719-4	1996	Glucose 6-phosphate decreased, modestly but significantly, B-cell glucokinase activity, such an inhibitory action being of the non-competitive type.	Glucose-6-Phosphate	0-19	glucokinase	Homo sapiens	66-77
8829218-8	1996	Glucose-6-phosphate, p-nitrophenylphosphate, or pyrophosphate were not hydrolyzed by the F1F0-ATPase, although some hydrolysis was observed with the tightly-bound ATPase.	Glucose-6-Phosphate	0-19	dynein axonemal heavy chain 8	Homo sapiens	94-100
8829218-8	1996	Glucose-6-phosphate, p-nitrophenylphosphate, or pyrophosphate were not hydrolyzed by the F1F0-ATPase, although some hydrolysis was observed with the tightly-bound ATPase.	Glucose-6-Phosphate	0-19	dynein axonemal heavy chain 8	Homo sapiens	163-169
8622603-5	1996	In contrast, fractional glucose-6-phosphate [G-6-P]) (0.1/10 mmol/L) skeletal muscle glycogen synthase activity in muscle biopsies obtained before and following the IV glucose bolus (-30, 30,60, and 120 minutes, respectively) were unchanged (38.1% +/- 2.3%, 38.3% +/- 2.9%, 38.1% +/- 2.3%, 35.4% +/- 2.3%, NS).	Glucose-6-Phosphate	24-43	glycogen synthase 1	Homo sapiens	69-102
8754272-4	1996	The protective effect of the allosteric activator (AMP), allosteric inhibitors (glucose 6-phosphate and FMN) and the competitive inhibitor (glucose) against heat denaturation of glycogen phosphorylase b has been demonstrated.	Glucose-6-Phosphate	80-99	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	178-202
8639816-4	1996	Neuroleukin mediates differentiation of neurons and is homologous to PGI, which catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	113-132	glucose-6-phosphate isomerase	Homo sapiens	0-11
8639816-4	1996	Neuroleukin mediates differentiation of neurons and is homologous to PGI, which catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	113-132	glucose-6-phosphate isomerase	Homo sapiens	69-72
8622603-5	1996	In contrast, fractional glucose-6-phosphate [G-6-P]) (0.1/10 mmol/L) skeletal muscle glycogen synthase activity in muscle biopsies obtained before and following the IV glucose bolus (-30, 30,60, and 120 minutes, respectively) were unchanged (38.1% +/- 2.3%, 38.3% +/- 2.9%, 38.1% +/- 2.3%, 35.4% +/- 2.3%, NS).	Glucose-6-Phosphate	45-50	glycogen synthase 1	Homo sapiens	69-102
8691743-2	1996	The glucose-6-phosphatase enzyme is an endoplasmic reticulum enzyme system which hydrolyzes glucose-6-phosphate to glucose and phosphate.	Glucose-6-Phosphate	92-111	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	4-25
8603759-7	1996	Hyperinsulinemia also totally prevented the normal insulin-stimulated threefold increase in the Vmax0.1 and the 65% decrease in the A0.5 for glucose-6-phosphate.	Glucose-6-Phosphate	141-160	insulin	Homo sapiens	5-12
9162607-4	1996	Glycogen synthase activity measured at 0.1 mmol 1(-1) glucose-6-phosphate correlated with insulin sensitivity as measured by a short insulin tolerance test (r = 0.42, p < 0.05) and the waist to hip ratio (r = -0.48, p < 0.01), but not body mass index, body fat percentage or age.	Glucose-6-Phosphate	54-73	insulin	Homo sapiens	90-97
8839454-3	1996	In contrast to liver microsomes, most (up to 80%) of the glucose-6-phosphate hydrolysing activity in muscle sarcoplasmic reticulum membranes was not inactivated by pH 5.0 pre-incubation indicating that it was not catalysed by the specific glucose-6-phosphatase enzyme.	Glucose-6-Phosphate	57-76	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	239-260
8700908-7	1996	While low glucokinase activity was detected in the liver of diabetic control mice, high levels of both glucokinase mRNA and enzyme activity were noted in the liver of streptozotocin-treated transgenic mice, which led to an increase in intracellular levels of glucose 6-phosphate and glycogen.	Glucose-6-Phosphate	259-278	glucokinase	Mus musculus	103-114
8772513-7	1996	We thus conclude that 1) transport is the rate-limiting step during DG accumulation, 2) G-6-P is a potent inhibitor of hexokinase activity compared with DG-6-P, so that enzyme inhibition may have physiological relevance in diverting glucose from metabolism during its active reabsorption in the small intestine, and 3) low levels of G-6-Pase activity seem to exclude this enzyme, and hence the endoplasmic reticulum, as important factors during the intracellular phase of glucose transport.	Glucose-6-Phosphate	88-93	hexokinase 1	Homo sapiens	119-129
8777333-11	1996	Due to the in vivo inhibition of the hexokinase component by glucose 6-phosphate, the glucokinase component in retina and lens may be predominant in vivo, making the stimulating effect of hyperglycemia much more important than it would appear from our in vitro data.	Glucose-6-Phosphate	61-80	hexokinase-2	Oryctolagus cuniculus	37-47
8777333-11	1996	Due to the in vivo inhibition of the hexokinase component by glucose 6-phosphate, the glucokinase component in retina and lens may be predominant in vivo, making the stimulating effect of hyperglycemia much more important than it would appear from our in vitro data.	Glucose-6-Phosphate	61-80	glucokinase	Oryctolagus cuniculus	86-97
8611029-0	1996	Glucose 6-phosphate and mannose 6-phosphate are equally and more actively hydrolyzed by glucose 6-phosphatase during hysteretic transition within intact microsomal membrane than after detergent treatment.	Glucose-6-Phosphate	0-19	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	88-109
8611029-1	1996	We have studied the rapid kinetics of glucose-6-phosphatase (Glc6Pase) toward glucose 6-phosphate (Glc6P) and mannose 6-phosphate (Man6P) in intact and detergent-treated microsomes, using a radiometric assay based on the use of [U(-)14C]hexose 6-phosphates.	Glucose-6-Phosphate	78-97	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	38-59
8611029-1	1996	We have studied the rapid kinetics of glucose-6-phosphatase (Glc6Pase) toward glucose 6-phosphate (Glc6P) and mannose 6-phosphate (Man6P) in intact and detergent-treated microsomes, using a radiometric assay based on the use of [U(-)14C]hexose 6-phosphates.	Glucose-6-Phosphate	78-97	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	61-69
8611029-1	1996	We have studied the rapid kinetics of glucose-6-phosphatase (Glc6Pase) toward glucose 6-phosphate (Glc6P) and mannose 6-phosphate (Man6P) in intact and detergent-treated microsomes, using a radiometric assay based on the use of [U(-)14C]hexose 6-phosphates.	Glucose-6-Phosphate	61-66	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	38-59
8567628-3	1996	Previous studies of HKI indicated that a glucose 6-phosphate (Glu-6-P)-regulated catalytic site resides in the COOH-terminal half of the molecule and that the NH2-terminal half contains only a Glu-6-P binding site.	Glucose-6-Phosphate	41-60	hexokinase 1	Homo sapiens	20-23
8567628-3	1996	Previous studies of HKI indicated that a glucose 6-phosphate (Glu-6-P)-regulated catalytic site resides in the COOH-terminal half of the molecule and that the NH2-terminal half contains only a Glu-6-P binding site.	Glucose-6-Phosphate	62-69	hexokinase 1	Homo sapiens	20-23
8567628-3	1996	Previous studies of HKI indicated that a glucose 6-phosphate (Glu-6-P)-regulated catalytic site resides in the COOH-terminal half of the molecule and that the NH2-terminal half contains only a Glu-6-P binding site.	Glucose-6-Phosphate	193-200	hexokinase 1	Homo sapiens	20-23
8567628-4	1996	In contrast, we now show that proteins representing both halves of human and rat HKII have catalytic activity and that each is inhibited by Glu-6-P.	Glucose-6-Phosphate	140-147	hexokinase 2	Rattus norvegicus	81-85
8721778-1	1996	UNLABELLED: Hexokinase II (HKII) plays a central role in the intracellular metabolism of glucose in skeletal muscle, catalysing the phosphorylation of glucose to glucose 6-phosphate.	Glucose-6-Phosphate	162-181	hexokinase 2	Homo sapiens	12-25
8721778-1	1996	UNLABELLED: Hexokinase II (HKII) plays a central role in the intracellular metabolism of glucose in skeletal muscle, catalysing the phosphorylation of glucose to glucose 6-phosphate.	Glucose-6-Phosphate	162-181	hexokinase 2	Homo sapiens	27-31
8611181-11	1996	Conversely, the glucose 6-phosphate level was increased by acidic pH1 and decreased by basic pH1.	Glucose-6-Phosphate	16-35	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	66-69
8611181-11	1996	Conversely, the glucose 6-phosphate level was increased by acidic pH1 and decreased by basic pH1.	Glucose-6-Phosphate	16-35	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	93-96
8772513-7	1996	We thus conclude that 1) transport is the rate-limiting step during DG accumulation, 2) G-6-P is a potent inhibitor of hexokinase activity compared with DG-6-P, so that enzyme inhibition may have physiological relevance in diverting glucose from metabolism during its active reabsorption in the small intestine, and 3) low levels of G-6-Pase activity seem to exclude this enzyme, and hence the endoplasmic reticulum, as important factors during the intracellular phase of glucose transport.	Glucose-6-Phosphate	88-93	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	333-341
7503565-2	1995	The 32P/14C ratio of Glc-6-P produced by the endogenous mitochondrially bound hexokinase (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) using [U-14C]Glc as substrate was determined as a function of time after initiation of oxidative phosphorylation.	Glucose-6-Phosphate	21-28	hexokinase	Saccharomyces cerevisiae S288C	78-88
8557765-5	1996	Specific glucose utilization rates were always close to specific hexokinase activities, indicating that formation of glucose-6-phosphate from glucose (catalyzed by hexokinase) is the rate limiting step of glycolysis.	Glucose-6-Phosphate	117-136	hexokinase 1	Homo sapiens	65-75
8557765-5	1996	Specific glucose utilization rates were always close to specific hexokinase activities, indicating that formation of glucose-6-phosphate from glucose (catalyzed by hexokinase) is the rate limiting step of glycolysis.	Glucose-6-Phosphate	117-136	hexokinase 1	Homo sapiens	164-174
7503565-3	1995	This same ratio was determined for Glc-6-P formed by added yeast hexokinase using extramitochondrial ATP as substrate.	Glucose-6-Phosphate	35-42	hexokinase	Saccharomyces cerevisiae S288C	65-75
7503565-5	1995	The 32P/14C ratio of Glc-6-P formed by yeast hexokinase, reflecting the specific activity of ATP in the extramitochondrial space, was rapidly responsive to such manipulations, but the corresponding changes in the 32P/14C ratio of Glc-6-P produced by the endogenous hexokinase were markedly different.	Glucose-6-Phosphate	21-28	hexokinase	Saccharomyces cerevisiae S288C	45-55
7503565-5	1995	The 32P/14C ratio of Glc-6-P formed by yeast hexokinase, reflecting the specific activity of ATP in the extramitochondrial space, was rapidly responsive to such manipulations, but the corresponding changes in the 32P/14C ratio of Glc-6-P produced by the endogenous hexokinase were markedly different.	Glucose-6-Phosphate	21-28	hexokinase	Saccharomyces cerevisiae S288C	265-275
7503565-5	1995	The 32P/14C ratio of Glc-6-P formed by yeast hexokinase, reflecting the specific activity of ATP in the extramitochondrial space, was rapidly responsive to such manipulations, but the corresponding changes in the 32P/14C ratio of Glc-6-P produced by the endogenous hexokinase were markedly different.	Glucose-6-Phosphate	230-237	hexokinase	Saccharomyces cerevisiae S288C	45-55
8786021-1	1995	In muscle, hexokinase II (HK2) regulates phosphorylation of glucose to glucose 6-phosphate, which has been reported to be impaired in patients with non-insulin-dependent diabetes mellitus (NIDDM).	Glucose-6-Phosphate	71-90	hexokinase 1	Homo sapiens	11-21
8786021-1	1995	In muscle, hexokinase II (HK2) regulates phosphorylation of glucose to glucose 6-phosphate, which has been reported to be impaired in patients with non-insulin-dependent diabetes mellitus (NIDDM).	Glucose-6-Phosphate	71-90	hexokinase 2	Homo sapiens	26-29
7487895-7	1995	As both glucose analogues are transported, but only 2-deoxyglucose is phosphorylated, this indicates that glucose transport and metabolism to glucose 6-phosphate is essential for insulin regulation of VSMC [Ca2+]i, possibly via a glucose-6-phosphate-dependent carbohydrate-response element in the Ca2(+)-ATPase gene.	Glucose-6-Phosphate	142-161	insulin	Homo sapiens	179-186
7487895-0	1995	Insulin stimulation of intracellular free Ca2+ recovery and Ca(2+)-ATPase gene expression in cultured vascular smooth-muscle cells: role of glucose 6-phosphate.	Glucose-6-Phosphate	140-159	insulin	Homo sapiens	0-7
7567971-9	1995	Several conclusions are significant: (i) glucose transport/hexokinase controls the glycogen synthesis flux; (ii) the role of covalent phosphorylation of GSase is to adapt the activity of the enzyme to the flux and to control the metabolite levels not the flux; (iii) the quantitative data needed for inferring and testing the present model of flux control depended upon advances of in vivo NMR methods that accurately measured the concentration of glucose 6-phosphate and the rate of glycogen synthesis.	Glucose-6-Phosphate	448-467	hexokinase 1	Homo sapiens	59-69
7574692-1	1995	The kinetics of the reaction of baker"s yeast glucose-6-phosphate dehydrogenase with excess 5,5"-dithiobis(2-nitrobenzoic acid) (DTNB) were studied at pH 8.5 and 30 degrees C and at constant ionic strength of 0.01 and in the absence and in the presence of NADP+ or glucose 6-phosphate.	Glucose-6-Phosphate	265-284	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	46-79
7646448-2	1995	It was found that glucose-6-phosphatase activity in histone II-A-pretreated liver microsomes was stimulated to the same extent as in detergent-permeabilized microsomes, and that the substrate specificity of the enzyme for glucose 6-phosphate was lost in histone II-A-pretreated microsomes, as [U-14C]glucose-6-phosphate hydrolysis was inhibited by mannose 6-phosphate and [U-14C]mannose 6-phosphate hydrolysis was increased.	Glucose-6-Phosphate	222-241	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	18-39
7673140-1	1995	We have investigated the kinetics of tracer uptake into rat liver microsomes in relation to [14C]glucose 6-phosphate (Glu-6-P) hydrolysis by glucose 6-phosphatase (Glu-6-Pase).	Glucose-6-Phosphate	97-116	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	141-162
7673140-1	1995	We have investigated the kinetics of tracer uptake into rat liver microsomes in relation to [14C]glucose 6-phosphate (Glu-6-P) hydrolysis by glucose 6-phosphatase (Glu-6-Pase).	Glucose-6-Phosphate	97-116	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	164-174
8690709-1	1995	Exposure of rat liver microsomes to ascorbic acid/Fe(2+) caused decreases in the membrane-bound glucose-6-phosphate (G-6-Pase) activity and the protein thiols after a short lag period (4 min).	Glucose-6-Phosphate	96-115	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	117-125
7646067-0	1995	Residues putatively involved in binding of ATP and glucose 6-phosphate to a mammalian hexokinase: site-directed mutation at analogous positions in the N- and C-terminal halves of the type I isozyme.	Glucose-6-Phosphate	51-70	hexokinase 1	Homo sapiens	86-96
7646448-2	1995	It was found that glucose-6-phosphatase activity in histone II-A-pretreated liver microsomes was stimulated to the same extent as in detergent-permeabilized microsomes, and that the substrate specificity of the enzyme for glucose 6-phosphate was lost in histone II-A-pretreated microsomes, as [U-14C]glucose-6-phosphate hydrolysis was inhibited by mannose 6-phosphate and [U-14C]mannose 6-phosphate hydrolysis was increased.	Glucose-6-Phosphate	300-319	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	18-39
7649406-11	1995	This change in glucokinase activity led to an increase in both glucose 6-phosphate and glycogen contents in the liver of transgenic mice.	Glucose-6-Phosphate	63-82	glucokinase	Mus musculus	15-26
7601970-5	1995	Following weaning, the rapid increase in the concentrations of glucose 6-phosphate and UDPgalactose suggested that the rate of lactose synthesis was regulated by the inhibition of hexokinase and/or lactose synthase, while the decrease in glucose and AMP indicated a subsequent decline in glucose and ATP utilization.	Glucose-6-Phosphate	63-82	hexokinase 1	Homo sapiens	180-190
7614462-9	1995	Tumor cell glucokinase activity has been characterized by its high Km for glucose (8-11.8 mM); inhibition by the specific glucokinase inhibitor, mannoheptulose (I50, 12.5 mM); and lack of inhibition by 10 mM glucose-6-phosphate.	Glucose-6-Phosphate	208-227	glucokinase	Homo sapiens	11-22
7612656-5	1995	Km for glucose-6-phosphate (G6P) does not vary significantly with temperature, whereas Km for NADP increases at increasing temperature, kcat increases with temperature, with a break point at 35 degrees C (in human G6PD, the break point is at 15 degrees C).	Glucose-6-Phosphate	7-26	glucose-6-phosphate dehydrogenase	Homo sapiens	214-218
7612656-5	1995	Km for glucose-6-phosphate (G6P) does not vary significantly with temperature, whereas Km for NADP increases at increasing temperature, kcat increases with temperature, with a break point at 35 degrees C (in human G6PD, the break point is at 15 degrees C).	Glucose-6-Phosphate	28-31	glucose-6-phosphate dehydrogenase	Homo sapiens	214-218
7774725-3	1995	The latter results are consistent with amylin and epinephrine stimulating glycogenolysis and inhibiting hexokinase activity by intracellular accumulation of glucose 6-phosphate.	Glucose-6-Phosphate	157-176	islet amyloid polypeptide	Rattus norvegicus	39-45
7601115-3	1995	It has been shown previously that glucose alone, via an increase in intracellular glucose-6-phosphate level, stimulated the accumulation of FAS mRNA in cultured white adipose tissue of suckling rats.	Glucose-6-Phosphate	82-101	fatty acid synthase	Rattus norvegicus	140-143
7601115-15	1995	The importance of glucokinase expression for the induction of FAS mRNA by glucose is supported by the striking correlation between glucose-6-phosphate concentrations and the levels of FAS mRNA.	Glucose-6-Phosphate	131-150	glucokinase	Rattus norvegicus	18-29
7601115-15	1995	The importance of glucokinase expression for the induction of FAS mRNA by glucose is supported by the striking correlation between glucose-6-phosphate concentrations and the levels of FAS mRNA.	Glucose-6-Phosphate	131-150	fatty acid synthase	Rattus norvegicus	62-65
7733874-1	1995	In native rat liver microsomes glucose 6-phosphatase activity is dependent not only on the activity of the glucose-6-phosphatase enzyme (which is lumenal) but also on the transport of glucose-6-phosphate, phosphate and glucose through the respective translocases T1, T2 and T3.	Glucose-6-Phosphate	184-203	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	31-52
7896692-2	1995	Transmembrane induction of uhpT expression by external glucose 6-phosphate is positively regulated by the promoter-specific activator protein UhpA and the global regulator catabolite gene activator protein (CAP).	Glucose-6-Phosphate	55-74	catabolite gene activator protein	Escherichia coli	172-211
7785782-2	1995	The product NADPH of the reaction between glucose-6-phosphate and NADP+ catalyzed by glucose-6-phosphate dehydrogenase (G6PDH) is monitored.	Glucose-6-Phosphate	42-61	glucose-6-phosphate dehydrogenase	Homo sapiens	85-118
7785782-2	1995	The product NADPH of the reaction between glucose-6-phosphate and NADP+ catalyzed by glucose-6-phosphate dehydrogenase (G6PDH) is monitored.	Glucose-6-Phosphate	42-61	glucose-6-phosphate dehydrogenase	Homo sapiens	120-125
7869925-8	1995	Glucose phosphorylation, evaluated by measuring the rate of glucose-6-phosphate formation in a fluorimetric assay, indicated that glucokinase activity had a maximum (Vmax) of 7.97 +/- 0.94 nmol/microgram DNA/h and a Km of 8.3 +/- 0.9 mmol/L (mean +/- SE, n = 8).	Glucose-6-Phosphate	60-79	glucokinase	Homo sapiens	130-141
7883122-2	1995	Since defects involving glucose transport and/or its phosphorylation to glucose-6-phosphate are present in muscle of insulin-resistant humans, HKII should be viewed as a candidate gene for inherited insulin resistance and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).	Glucose-6-Phosphate	72-91	insulin	Homo sapiens	117-124
7883122-2	1995	Since defects involving glucose transport and/or its phosphorylation to glucose-6-phosphate are present in muscle of insulin-resistant humans, HKII should be viewed as a candidate gene for inherited insulin resistance and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM).	Glucose-6-Phosphate	72-91	hexokinase 2	Homo sapiens	143-147
7883123-2	1995	Since reduced insulin-stimulated glucose uptake and reduced glucose-6-phosphate content in muscle have been demonstrated in pre-non-insulin-dependent diabetes mellitus (pre-NIDDM) and NIDDM subjects, we have examined the coding region of the HKII gene in NIDDM patients to determine whether these patients show genetic polymorphisms that are associated with or contribute to the disease.	Glucose-6-Phosphate	60-79	hexokinase 2	Homo sapiens	242-246
7827108-4	1995	Vmax values of G6PDH for glucose-6-phosphate decreased mainly in intermediate and pericentral zones after partial hepatectomy, whereas they increased after PB treatment.	Glucose-6-Phosphate	25-44	glucose-6-phosphate dehydrogenase	Rattus norvegicus	15-20
7827108-6	1995	The affinity of G6PDH for glucose-6-phosphate was similar in all zones and it was decreased 2-3 fold by PB and 3-MC treatment.	Glucose-6-Phosphate	26-45	glucose-6-phosphate dehydrogenase	Rattus norvegicus	16-21
7803494-4	1994	The inhibition of the phosphorylation of phosphorylase b by glucose 6-phosphate may explain the reported decreased phosphorylation of phosphorylase in muscle following insulin treatment, which elevates intracellular levels of glucose 6-phosphate.	Glucose-6-Phosphate	60-79	insulin	Homo sapiens	168-175
7803494-4	1994	The inhibition of the phosphorylation of phosphorylase b by glucose 6-phosphate may explain the reported decreased phosphorylation of phosphorylase in muscle following insulin treatment, which elevates intracellular levels of glucose 6-phosphate.	Glucose-6-Phosphate	226-245	insulin	Homo sapiens	168-175
7955370-3	1994	In the method used here, glucokinase and an ATP-regenerating system efficiently convert glucose to the unreactive compound, glucose 6-phosphate, making the method selective for 1,5-AG.	Glucose-6-Phosphate	124-143	glucokinase	Homo sapiens	25-36
7706226-1	1994	Glucose-6-phosphatase (Glc6Pase) is a liver microsomal protein exhibiting a high specificity for glucose-6-phosphate (Glc6P) when present in the intact membrane.	Glucose-6-Phosphate	97-116	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
7706226-1	1994	Glucose-6-phosphatase (Glc6Pase) is a liver microsomal protein exhibiting a high specificity for glucose-6-phosphate (Glc6P) when present in the intact membrane.	Glucose-6-Phosphate	97-116	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	23-31
7706226-1	1994	Glucose-6-phosphatase (Glc6Pase) is a liver microsomal protein exhibiting a high specificity for glucose-6-phosphate (Glc6P) when present in the intact membrane.	Glucose-6-Phosphate	23-28	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
7706226-8	1994	These data provide direct evidence that, in the presence of both Glc6P and Man6P, Glc6Pase is able to exhibit a specific, albeit limited, kinetic behavior towards the former after detergent treatment of the membrane.	Glucose-6-Phosphate	65-70	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	82-90
7926301-1	1994	We wished to determine whether the elevated glucose cycling (GC) between glucose and glucose-6-phosphate (G<-->G6P) in diabetes can be reversed with acute insulin treatment.	Glucose-6-Phosphate	85-104	insulin	Canis lupus familiaris	161-168
7980534-3	1994	The decreased glucose-6-phosphate levels correlated with increased activity of liver glucose-6-phosphatase and a concomitant 2.5-fold increase in glucose-6-phosphatase mRNA abundance.	Glucose-6-Phosphate	14-33	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	85-106
24306501-3	1994	The sensitivities of PEP carboxylase to the allosteric effectors malate and glucose-6-phosphate were markedly different between C3 and C4 species.	Glucose-6-Phosphate	76-95	phosphoenolpyruvate carboxylase 2	Zea mays	21-24
7980534-3	1994	The decreased glucose-6-phosphate levels correlated with increased activity of liver glucose-6-phosphatase and a concomitant 2.5-fold increase in glucose-6-phosphatase mRNA abundance.	Glucose-6-Phosphate	14-33	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	146-167
7929149-0	1994	The 50-kDa glucose 6-phosphate-sensitive hexokinase of Schistosoma mansoni.	Glucose-6-Phosphate	11-30	hexokinase	Schistosoma mansoni	41-51
7947952-1	1994	3-Mercaptopicolinate (3-MP) inhibits D-glucose-6-phosphate (G6P) phosphohydrolase activity of the glucose-6-phosphatase system (Bode et al.	Glucose-6-Phosphate	37-58	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	98-119
7929149-5	1994	With these kinetic properties and 50 kDa molecular mass, S. mansoni hexokinase resembles the ancestral hexokinase predicted to have given rise, by gene duplication and fusion, to the present day 100-kDa Glc-6-P-sensitive mammalian hexokinases.	Glucose-6-Phosphate	203-210	hexokinase	Schistosoma mansoni	68-78
7929149-5	1994	With these kinetic properties and 50 kDa molecular mass, S. mansoni hexokinase resembles the ancestral hexokinase predicted to have given rise, by gene duplication and fusion, to the present day 100-kDa Glc-6-P-sensitive mammalian hexokinases.	Glucose-6-Phosphate	203-210	hexokinase	Schistosoma mansoni	103-113
7929149-6	1994	The schistosomal hexokinase represents the first 50-kDa Glc-6-P-sensitive hexokinase whose sequence has been obtained.	Glucose-6-Phosphate	56-63	hexokinase	Schistosoma mansoni	17-27
7929149-6	1994	The schistosomal hexokinase represents the first 50-kDa Glc-6-P-sensitive hexokinase whose sequence has been obtained.	Glucose-6-Phosphate	56-63	hexokinase	Schistosoma mansoni	74-84
7929149-8	1994	The marked Crabtree effect exhibited by S. mansoni cercariae may be at least partly attributed to the expression of rather high levels of a hexokinase having a high affinity for glucose but only a moderate sensitivity to product inhibition by Glc-6-P.	Glucose-6-Phosphate	243-250	hexokinase	Schistosoma mansoni	140-150
8040253-3	1994	In vitro nonezymatic glycosylation of basic fibroblast growth factor (bFGF) by fructose, glucose-6-phosphate (G6P), or glyceraldehyde-3-phosphate (G3P) reduced high affinity heparin-binding activity of recombinant bFGF by 73, 77, and 89%, respectively.	Glucose-6-Phosphate	89-108	fibroblast growth factor 2	Bos taurus	38-68
7962304-5	1994	When untreated normal human or rat microsomes were incubated in the presence of 0.2 mmol/L [U-14C]G6P, an accumulation of [U-14C]glucose was observed, whereas no radioactive compound (G6P and/or glucose) was taken up by GSD 1a microsomes.	Glucose-6-Phosphate	98-101	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	220-226
7983782-1	1994	Glucokinase is a key enzyme of glucose metabolism that phosphorylates glucose to glucose-6-phosphate (G-6-P).	Glucose-6-Phosphate	81-100	glucokinase	Homo sapiens	0-11
7983782-1	1994	Glucokinase is a key enzyme of glucose metabolism that phosphorylates glucose to glucose-6-phosphate (G-6-P).	Glucose-6-Phosphate	102-107	glucokinase	Homo sapiens	0-11
8040253-3	1994	In vitro nonezymatic glycosylation of basic fibroblast growth factor (bFGF) by fructose, glucose-6-phosphate (G6P), or glyceraldehyde-3-phosphate (G3P) reduced high affinity heparin-binding activity of recombinant bFGF by 73, 77, and 89%, respectively.	Glucose-6-Phosphate	89-108	fibroblast growth factor 2	Bos taurus	70-74
8040253-3	1994	In vitro nonezymatic glycosylation of basic fibroblast growth factor (bFGF) by fructose, glucose-6-phosphate (G6P), or glyceraldehyde-3-phosphate (G3P) reduced high affinity heparin-binding activity of recombinant bFGF by 73, 77, and 89%, respectively.	Glucose-6-Phosphate	110-113	fibroblast growth factor 2	Bos taurus	38-68
8040253-3	1994	In vitro nonezymatic glycosylation of basic fibroblast growth factor (bFGF) by fructose, glucose-6-phosphate (G6P), or glyceraldehyde-3-phosphate (G3P) reduced high affinity heparin-binding activity of recombinant bFGF by 73, 77, and 89%, respectively.	Glucose-6-Phosphate	110-113	fibroblast growth factor 2	Bos taurus	70-74
7510884-1	1994	Phosphorylation of glucose to glucose 6-phosphate by glucokinase (GK; EC 2.7.1.2) serves as a glucose-sensing mechanism for regulating insulin secretion in beta cells.	Glucose-6-Phosphate	30-49	glucokinase	Mus musculus	53-64
8206976-6	1994	In agreement with the fact that total glucose output tends to decrease upon prolonged fasting, the increase of Glc-6-P concentration in the liver of 72-h fasted rats suggests the involvement of a metabolite inhibition of Glc-6-Pase.	Glucose-6-Phosphate	111-118	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	221-231
8039433-11	1994	Glucose deposition as glycogen in muscle is regulated by glycogen synthase (GS), which during insulin stimulation undergoes dephosphorylation and becomes more active at physiological concentrations of glucose-6-phosphate.	Glucose-6-Phosphate	201-220	insulin	Homo sapiens	94-101
12232248-6	1994	In the presence of Triton X-100 the H+-ATPase catalyzes the cleavage of glucose-6-phosphate when both hexokinase and ADP are included in the assay medium.	Glucose-6-Phosphate	72-91	ATPase	Zea mays	39-45
8020491-7	1994	FTOGK and H4GK showed an increase in the content of glucose 6-phosphate, and were able to accumulate high levels of glycogen, in contrast to FTO-2B cells, which were unable to store the polysaccharide.	Glucose-6-Phosphate	52-71	FTO, alpha-ketoglutarate dependent dioxygenase	Rattus norvegicus	0-3
8179326-0	1994	Mitochondrial hexokinase in brain: coexistence of forms differing in sensitivity to solubilization by glucose-6-phosphate on the same mitochondria.	Glucose-6-Phosphate	102-121	hexokinase 1	Homo sapiens	14-24
8179326-8	1994	Treatment of mitochondria from guinea pig, bovine, and human brain with Glc-6-P solubilized approximately 60, 40, and 20% of the bound hexokinase activity, respectively, but had no effect on the extent to which the mitochondria could be immunoprecipitated.	Glucose-6-Phosphate	72-79	hexokinase 1	Homo sapiens	135-145
8179326-9	1994	This is consistent with the view that the residual hexokinase, resistant to solubilization with Glc-6-P, coexists on the same mitochondria bearing the Glc-6-P-sensitive form, i.e., removal of the latter does not prevent immunoprecipitation mediated by the Glc-6-P-resistant form.	Glucose-6-Phosphate	96-103	hexokinase 1	Homo sapiens	51-61
8179326-9	1994	This is consistent with the view that the residual hexokinase, resistant to solubilization with Glc-6-P, coexists on the same mitochondria bearing the Glc-6-P-sensitive form, i.e., removal of the latter does not prevent immunoprecipitation mediated by the Glc-6-P-resistant form.	Glucose-6-Phosphate	151-158	hexokinase 1	Homo sapiens	51-61
8179326-9	1994	This is consistent with the view that the residual hexokinase, resistant to solubilization with Glc-6-P, coexists on the same mitochondria bearing the Glc-6-P-sensitive form, i.e., removal of the latter does not prevent immunoprecipitation mediated by the Glc-6-P-resistant form.	Glucose-6-Phosphate	151-158	hexokinase 1	Homo sapiens	51-61
8179326-12	1994	The extent to which Glc-6-P solubilizes hexokinase from rat and bovine brain mitochondria is approximately 90 and approximately 40%, respectively.	Glucose-6-Phosphate	20-27	hexokinase 1	Homo sapiens	40-50
7510884-1	1994	Phosphorylation of glucose to glucose 6-phosphate by glucokinase (GK; EC 2.7.1.2) serves as a glucose-sensing mechanism for regulating insulin secretion in beta cells.	Glucose-6-Phosphate	30-49	glucokinase	Mus musculus	66-68
8033949-3	1994	Prolonged treatment with GH decreased the rate of glucose transport and glycogen synthesis and increased the content of glucose 6-phosphate at physiological levels of insulin but did not affect the rate of lactate formation.	Glucose-6-Phosphate	120-139	gonadotropin releasing hormone receptor	Rattus norvegicus	25-27
8117658-0	1994	An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.	Glucose-6-Phosphate	118-137	aldo-keto reductase family 1 member B	Homo sapiens	31-47
8117658-9	1994	Glucose 6-phosphate, however, is a substrate for aldose reductase.	Glucose-6-Phosphate	0-19	aldo-keto reductase family 1 member B	Homo sapiens	49-65
8141125-3	1994	The markedly abnormal kinetics of glucose-6-phosphate (G6P) of G6PD Kobe suggest the interaction between both NADP and G6P binding sites.	Glucose-6-Phosphate	34-53	glucose-6-phosphate dehydrogenase	Homo sapiens	63-67
8141125-3	1994	The markedly abnormal kinetics of glucose-6-phosphate (G6P) of G6PD Kobe suggest the interaction between both NADP and G6P binding sites.	Glucose-6-Phosphate	55-58	glucose-6-phosphate dehydrogenase	Homo sapiens	63-67
8163045-1	1994	Reduced insulin action on skeletal muscle glycogen synthase activity and reduced whole-body insulin-mediated glucose disposal rates in insulin-resistant subjects may be associated with an alteration in muscle glucose transport (or phosphorylation) or with a defect distal to glucose 6-phosphate.	Glucose-6-Phosphate	275-294	insulin	Macaca mulatta	8-15
8112322-12	1994	Glut7 is the transporter present in the endoplasmic reticulum membrane that allows the flux of free glucose out of the lumen of this organelle after the action of glucose-6-phosphatase on glucose 6-phosphate.	Glucose-6-Phosphate	188-207	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	163-184
8112322-12	1994	Glut7 is the transporter present in the endoplasmic reticulum membrane that allows the flux of free glucose out of the lumen of this organelle after the action of glucose-6-phosphatase on glucose 6-phosphate.	Glucose-6-Phosphate	188-207	solute carrier family 2 member 7	Homo sapiens	0-5
8071087-8	1994	The Km was 0.62 mM and the Vmax 3 mumol glucose-6-phosphate/cm3 wet tissue and per min at 25 degrees C. It is concluded that G6PD in oligodendrocytes may be important for the generation of NADPH required for lipid biosynthesis related to myelogenesis, and reduction of glutathione required for protection of membrane sulphydryl groups.	Glucose-6-Phosphate	40-59	glucose-6-phosphate dehydrogenase	Rattus norvegicus	125-129
8163045-1	1994	Reduced insulin action on skeletal muscle glycogen synthase activity and reduced whole-body insulin-mediated glucose disposal rates in insulin-resistant subjects may be associated with an alteration in muscle glucose transport (or phosphorylation) or with a defect distal to glucose 6-phosphate.	Glucose-6-Phosphate	275-294	insulin	Macaca mulatta	92-99
8163045-1	1994	Reduced insulin action on skeletal muscle glycogen synthase activity and reduced whole-body insulin-mediated glucose disposal rates in insulin-resistant subjects may be associated with an alteration in muscle glucose transport (or phosphorylation) or with a defect distal to glucose 6-phosphate.	Glucose-6-Phosphate	275-294	insulin	Macaca mulatta	92-99
8163045-4	1994	The glucose 6-phosphate measured under insulin-stimulated conditions was inversely correlated to insulin-stimulated glycogen synthase independent activity (r = -0.54, p < 0.005), the change in glycogen synthase independent activity (insulin-stimulated minus basal) (r = -0.58, p < 0.002) and to whole-body insulin-mediated glucose disposal rate (r = -0.60, p < 0.002).	Glucose-6-Phosphate	4-23	insulin	Macaca mulatta	39-46
8163045-4	1994	The glucose 6-phosphate measured under insulin-stimulated conditions was inversely correlated to insulin-stimulated glycogen synthase independent activity (r = -0.54, p < 0.005), the change in glycogen synthase independent activity (insulin-stimulated minus basal) (r = -0.58, p < 0.002) and to whole-body insulin-mediated glucose disposal rate (r = -0.60, p < 0.002).	Glucose-6-Phosphate	4-23	insulin	Macaca mulatta	97-104
8163045-4	1994	The glucose 6-phosphate measured under insulin-stimulated conditions was inversely correlated to insulin-stimulated glycogen synthase independent activity (r = -0.54, p < 0.005), the change in glycogen synthase independent activity (insulin-stimulated minus basal) (r = -0.58, p < 0.002) and to whole-body insulin-mediated glucose disposal rate (r = -0.60, p < 0.002).	Glucose-6-Phosphate	4-23	insulin	Macaca mulatta	97-104
8163045-4	1994	The glucose 6-phosphate measured under insulin-stimulated conditions was inversely correlated to insulin-stimulated glycogen synthase independent activity (r = -0.54, p < 0.005), the change in glycogen synthase independent activity (insulin-stimulated minus basal) (r = -0.58, p < 0.002) and to whole-body insulin-mediated glucose disposal rate (r = -0.60, p < 0.002).	Glucose-6-Phosphate	4-23	insulin	Macaca mulatta	97-104
8163045-5	1994	The insulin-resistant and diabetic monkeys had significantly higher insulin-stimulated glucose 6-phosphate concentrations (0.57 +/- 0.11 and 0.62 +/- 0.11 nmol/mg dry weight, respectively) compared to the normal monkeys (0.29 +/- 0.05 nmol/mg dry weight) (p"s < 0.05).	Glucose-6-Phosphate	87-106	insulin	Macaca mulatta	4-11
8163045-5	1994	The insulin-resistant and diabetic monkeys had significantly higher insulin-stimulated glucose 6-phosphate concentrations (0.57 +/- 0.11 and 0.62 +/- 0.11 nmol/mg dry weight, respectively) compared to the normal monkeys (0.29 +/- 0.05 nmol/mg dry weight) (p"s < 0.05).	Glucose-6-Phosphate	87-106	insulin	Macaca mulatta	68-75
8163045-6	1994	We conclude that under euglycaemic/hyperinsulinaemic conditions, a defect distal to glucose 6-phosphate is a major contributor to reduced whole-body insulin-mediated glucose disposal rates and to reduced insulin action on glycogen synthase in insulin-resistant and diabetic monkeys.	Glucose-6-Phosphate	84-103	insulin	Macaca mulatta	40-47
8163045-6	1994	We conclude that under euglycaemic/hyperinsulinaemic conditions, a defect distal to glucose 6-phosphate is a major contributor to reduced whole-body insulin-mediated glucose disposal rates and to reduced insulin action on glycogen synthase in insulin-resistant and diabetic monkeys.	Glucose-6-Phosphate	84-103	insulin	Macaca mulatta	149-156
8163045-6	1994	We conclude that under euglycaemic/hyperinsulinaemic conditions, a defect distal to glucose 6-phosphate is a major contributor to reduced whole-body insulin-mediated glucose disposal rates and to reduced insulin action on glycogen synthase in insulin-resistant and diabetic monkeys.	Glucose-6-Phosphate	84-103	insulin	Macaca mulatta	149-156
8125383-5	1994	On this basis, although enterocyte hexokinase activity is much higher than in other "glycolytic" cells (for example, brain), potentially high rates of glucose utilisation are modulated by substrate cycling of glucose 6-phosphate back to glucose through glucose 6-phosphatase.	Glucose-6-Phosphate	209-228	hexokinase 1	Homo sapiens	35-45
8311478-10	1994	The reduced kinase binding activity of porin is preserved after isolation of porin from glimepiride-treated cells, reconstitution into phospholipid vesicles and assaying for glucose 6-phosphate inhibitable binding of rat liver hexokinase.	Glucose-6-Phosphate	174-193	hexokinase	Saccharomyces cerevisiae S288C	227-237
8125383-5	1994	On this basis, although enterocyte hexokinase activity is much higher than in other "glycolytic" cells (for example, brain), potentially high rates of glucose utilisation are modulated by substrate cycling of glucose 6-phosphate back to glucose through glucose 6-phosphatase.	Glucose-6-Phosphate	209-228	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	253-274
8250871-2	1993	Phosphoglucomutase and hexokinase lead to the formation of glucose 6-phosphate which in turn is used as an ATP regenerating system by the Ca2+ pump.	Glucose-6-Phosphate	59-78	hexokinase 1	Homo sapiens	23-33
8280078-16	1993	Since 2-3H is lost during conversion of glucose 6-phosphate into fructose 6-phosphate, substrate-induced translocation of glucokinase from a Mg(2+)-dependent binding site to an alternative site might favour the partitioning of glucose 6-phosphate towards glycogen, as opposed to phosphoglucoisomerase.	Glucose-6-Phosphate	40-59	glucokinase	Homo sapiens	122-133
8280078-16	1993	Since 2-3H is lost during conversion of glucose 6-phosphate into fructose 6-phosphate, substrate-induced translocation of glucokinase from a Mg(2+)-dependent binding site to an alternative site might favour the partitioning of glucose 6-phosphate towards glycogen, as opposed to phosphoglucoisomerase.	Glucose-6-Phosphate	227-246	glucokinase	Homo sapiens	122-133
8307259-1	1993	Type 2 (non-insulin-dependent) diabetes mellitus is characterized by decreased levels of glucose 6-phosphate in skeletal muscle.	Glucose-6-Phosphate	89-108	insulin	Homo sapiens	12-19
8344989-0	1993	Interaction of facilitative glucose transporter with glucokinase and its modulation by ADP and glucose-6-phosphate.	Glucose-6-Phosphate	95-114	glucokinase	Homo sapiens	53-64
8103051-5	1993	Glucose caused a dose-dependent rise in the glucose 6-phosphate content of INS-1 cells.	Glucose-6-Phosphate	44-63	insulin 1	Rattus norvegicus	75-80
8395816-10	1993	This finding invalidates the past inference from the failure of brain microsomes to distinguish mannose 6-phosphate and glucose 6-phosphate that the cerebral glucose-6-phosphatase system lacks a "glucose 6-phosphate translocase" [Fishman and Karnovsky (1986) J. Neurochem.	Glucose-6-Phosphate	196-215	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	158-179
8395816-8	1993	However, we demonstrate significant phosphomannose isomerase activity in brain microsomes, allowing for ready interconversion between mannose 6-phosphate and glucose 6-phosphate (Vmax.	Glucose-6-Phosphate	158-177	mannose phosphate isomerase	Rattus norvegicus	36-60
8508783-5	1993	Transcriptional induction of the PDC1 gene (encoding pyruvate decarboxylase) was observed after glucose or galactose pulses were applied to the pgi1 strain, demonstrating that metabolism of these sugars beyond glucose 6-phosphate is dispensable for PDC1 induction.	Glucose-6-Phosphate	210-229	indolepyruvate decarboxylase 1	Saccharomyces cerevisiae S288C	33-37
8331662-0	1993	Crystallographic binding studies on the allosteric inhibitor glucose-6-phosphate to T state glycogen phosphorylase b.	Glucose-6-Phosphate	61-80	glycogen phosphorylase B	Homo sapiens	92-116
8331662-1	1993	Glucose-6-phosphate is an important allosteric inhibitor of glycogen phosphorylase b that restrains the enzyme in the inactive state in resting muscle.	Glucose-6-Phosphate	0-19	glycogen phosphorylase B	Homo sapiens	60-84
8330686-7	1993	These animals had a significant content of glycogen and glucose 6-phosphate, which was related to the levels of glucokinase mRNA in the liver.	Glucose-6-Phosphate	56-75	glucokinase	Mus musculus	112-123
8508783-3	1993	Glucose and galactose pulses inhibited fructose consumption and thus glycolysis in the pgi1 strain by a combination of competition between glucose and fructose at the uptake and/or phosphorylation level and inhibition of fructose uptake and/or phosphorylation by glucose 6-phosphate.	Glucose-6-Phosphate	263-282	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	87-91
8393658-7	1993	Arabinose, xylose, mannose, ribose, fructose and glucose 6-phosphate (but not mannitol) were also able to inactive the ATPase.	Glucose-6-Phosphate	49-68	dynein axonemal heavy chain 8	Homo sapiens	119-125
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	Glucose-6-Phosphate	204-223	glucose-6-phosphate isomerase	Homo sapiens	14-38
8466644-1	1993	The human glucose-6-phosphate (G6PD) cDNAs cloned from normal and carcinoma cells can encode 545-amino-acid residues starting from the first in-frame chain initiation codon.	Glucose-6-Phosphate	10-29	glucose-6-phosphate dehydrogenase	Homo sapiens	31-35
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	Glucose-6-Phosphate	204-223	glucose-6-phosphate isomerase	Homo sapiens	40-43
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	Glucose-6-Phosphate	225-228	glucose-6-phosphate isomerase	Homo sapiens	14-38
8381960-1	1993	With 13C NMR, phosphoglucose isomerase (PGI; D-glucose-6-phosphate ketol-isomerase, EC 5.3.1.9) is shown to produce mannose 6-phosphate (M6P) slowly from a much more rapidly catalyzed equilibrium between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	Glucose-6-Phosphate	225-228	glucose-6-phosphate isomerase	Homo sapiens	40-43
8458523-0	1993	Contribution of glucose/glucose 6-phosphate cycle activity to insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus.	Glucose-6-Phosphate	24-43	insulin	Homo sapiens	62-69
8385243-2	1993	Glucose-6-phosphatase has been shown to comprise at least five different polypeptides, the catalytic subunit, a regulatory Ca2+ binding protein, three transport proteins (glucose-6-phosphate, phosphate/pyrophosphate, glucose).	Glucose-6-Phosphate	171-190	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
1290837-1	1992	Glucose-6-phosphate residues were revealed by fine structural analysis using glucose-6-phosphate dehydrogenase-gold conjugate.	Glucose-6-Phosphate	0-19	glucose-6-phosphate dehydrogenase	Homo sapiens	77-110
8446221-5	1993	Various mechanisms have been proposed, whereby hyperglycaemia may diminish insulin release: inhibition of Ca2+ mobilization from the endoplasmic reticulum by glucose-6-phosphate, Ca2+ uptake in the ER by glucose and inhibitory effects of protein kinase C. Whatever may prove to be the underlying mechanism(s), glucose toxicity is unlikely to be the only cause of insulin secretory disturbances in NIDDM, since the glucose level would have to be elevated before it could be toxic.	Glucose-6-Phosphate	158-177	insulin	Homo sapiens	75-82
8430777-6	1993	The muscle glucose 6-phosphate concentration progressively increased during the CGRP infusions.	Glucose-6-Phosphate	11-30	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
8467527-7	1993	However, the ggs1 delta, hxk2 delta double mutant still displayed a high level of glucose-6-phosphate as well as the rapid appearance of free intracellular glucose.	Glucose-6-Phosphate	82-101	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	13-17
8467527-7	1993	However, the ggs1 delta, hxk2 delta double mutant still displayed a high level of glucose-6-phosphate as well as the rapid appearance of free intracellular glucose.	Glucose-6-Phosphate	82-101	hexokinase 2	Saccharomyces cerevisiae S288C	25-29
1445275-5	1992	Glucose, glucose 6-phosphate and fructose all displayed a time-dependent inhibition of glutathione reductase activity, suggesting that these sugars glycate this enzyme.	Glucose-6-Phosphate	9-28	glutathione-disulfide reductase	Homo sapiens	87-108
8391444-7	1993	The uptake of glucose-6-phosphate has taken place in liposomes of Sepharose affinity purified products suggesting that this preparation may be a complex of PH and glucose-6-phosphate translocase.	Glucose-6-Phosphate	14-33	solute carrier family 37 member 4	Homo sapiens	163-194
8391445-4	1993	On the basis of the available data it is impossible to know whether a primary functional deficit of the glucose 6-phosphate transport protein of the microsomal glucose 6-phosphatase system, as demonstrated in liver, also exists in these phagocytic cells and is responsible for this dysfunction.	Glucose-6-Phosphate	104-123	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	160-181
7975408-2	1993	Elevated glucose level observed in rats with insulin insufficiency was associated with hexokinase activity inhibition and changes in the activity of the enzymes involved in glucose-6-phosphate transformation: enhanced activity of glucose-6-phosphatase and glucose-6-phosphate dehydrogenase against inhibition of phosphoglucomutase activity.	Glucose-6-Phosphate	173-192	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	230-251
7975408-2	1993	Elevated glucose level observed in rats with insulin insufficiency was associated with hexokinase activity inhibition and changes in the activity of the enzymes involved in glucose-6-phosphate transformation: enhanced activity of glucose-6-phosphatase and glucose-6-phosphate dehydrogenase against inhibition of phosphoglucomutase activity.	Glucose-6-Phosphate	173-192	glucose-6-phosphate dehydrogenase	Rattus norvegicus	256-289
1356982-10	1992	Glucose 6-phosphate concentrations in adipose tissue pieces cultured in various conditions changed in parallel with the FAS and ACC mRNA levels.	Glucose-6-Phosphate	0-19	fatty acid synthase	Rattus norvegicus	120-123
1319283-2	1992	In order to evaluate the degree of ER membrane integrity, glucose-6-phosphatase (G6P-A) was localized in light and electron microscopy using glucose-6-phosphate (G6P) and mannose-6-phosphate (M6P) as substrates.	Glucose-6-Phosphate	141-160	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	58-79
16653139-3	1992	The combination of glycine and glucose 6-phosphate synergistically reduced the apparent K(m) of the enzyme for PEP and increased the apparent V(max).	Glucose-6-Phosphate	31-50	phosphoenolpyruvate carboxylase 2	Zea mays	111-114
16653139-9	1992	A study of analogs of glucose 6-phosphate with Crassula PEP carboxylase revealed that the identity of the ring heteroatom was a significant structural feature affecting activation.	Glucose-6-Phosphate	22-41	phosphoenolpyruvate carboxylase 2	Zea mays	56-59
1318223-3	1992	It was found that the pre-incubation of intact microsomes with mannose-6-phosphate or glucose-6-phosphate (50 microM for 30 s) suppressed the burst in glucose-6-phosphatase activity, that the hysteretic transition was reversible and that mannose-6-phosphate inhibited glucose-6-phosphate hydrolysis during the first seconds of incubation, but not anymore after the burst.	Glucose-6-Phosphate	86-105	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	151-172
1637311-5	1992	In the absence of insulin, low levels of IGF-I (0-30 ng/ml) increased the rate of glycolysis and the content of fructose 2,6-bisphosphate, but the content of glucose 6-phosphate remained unaltered; at higher levels of IGF-I (300-3000 ng/ml) the rate of glycolysis and the content of fructose 2,6-bisphosphate showed a further modest increase, but the content of glucose 6-phosphate doubled.	Glucose-6-Phosphate	362-381	insulin-like growth factor 1	Rattus norvegicus	41-46
1319283-2	1992	In order to evaluate the degree of ER membrane integrity, glucose-6-phosphatase (G6P-A) was localized in light and electron microscopy using glucose-6-phosphate (G6P) and mannose-6-phosphate (M6P) as substrates.	Glucose-6-Phosphate	141-160	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	81-86
1319283-2	1992	In order to evaluate the degree of ER membrane integrity, glucose-6-phosphatase (G6P-A) was localized in light and electron microscopy using glucose-6-phosphate (G6P) and mannose-6-phosphate (M6P) as substrates.	Glucose-6-Phosphate	81-84	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	58-79
20732121-8	1992	Growth retardation and severity of malformations induced by 304 mum-acrylonitrile were significantly increased by the addition of a hepatic microsomal preparation (S-9, microsomes) and cofactors for cytochrome P-450-dependent biotransformation (NADPH, glucose-6-phosphate) to the culture medium.	Glucose-6-Phosphate	252-271	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	199-215
1568529-2	1992	Insulin-stimulated glucose storage (20.1 +/- 1.5 and 11.6 +/- 1.7 vs. 27.9 +/- 1.7 mumol.kg-1 lean body mass [LBM].min-1, P less than 0.01-0.001 [3.6 +/- 0.3 and 2.1 +/- 0.3 vs. 5.0 +/- 0.3 mg.kg-1 LBM.min-1] and glycogen synthase activity, measured at 0.1 mM glucose-6-phosphate concentration (11.3 +/- 1.3 and 11.6 +/- 1.3 vs. 18.3 +/- 2.0 nmol.min-1.mg-1 protein, P less than 0.01), were impaired in relatives and diabetic subjects compared with control subjects.	Glucose-6-Phosphate	260-279	insulin	Homo sapiens	0-7
1386834-5	1992	These results showed that p64 was phosphoglucomutase in PMN and that phosphate incorporation into p64 was a conversion of a phosphate group in glucose-6-phosphate produced by hexokinase.	Glucose-6-Phosphate	143-162	interleukin 2 receptor subunit gamma	Homo sapiens	26-29
1386834-5	1992	These results showed that p64 was phosphoglucomutase in PMN and that phosphate incorporation into p64 was a conversion of a phosphate group in glucose-6-phosphate produced by hexokinase.	Glucose-6-Phosphate	143-162	interleukin 2 receptor subunit gamma	Homo sapiens	98-101
1386834-5	1992	These results showed that p64 was phosphoglucomutase in PMN and that phosphate incorporation into p64 was a conversion of a phosphate group in glucose-6-phosphate produced by hexokinase.	Glucose-6-Phosphate	143-162	hexokinase 1	Homo sapiens	175-185
1559409-15	1992	This means that the defect in insulin activation can be compensated for by increased intracellular concentrations of G-6-P.	Glucose-6-Phosphate	117-122	insulin	Homo sapiens	30-37
1314605-4	1992	The inhibition on thrombin-induced aggregation is shared, albeit less efficiently, by glucose-1,6-diphosphate and fructose-2,6-diphosphate but not by other phosphorylated monosaccharides (fructose-1:2 cyclic,6-diphosphate, glucose-1- and glucose-6-phosphate, fructose-1- and fructose-6-phosphate, mannose-6-phosphate and 5-phosphoryl ribose-1-pyrophosphate).	Glucose-6-Phosphate	238-257	coagulation factor II, thrombin	Homo sapiens	18-26
1556176-11	1992	Increasing insulin concentrations to insulin 8,500 pmol/liter in four NIDDM subjects restored the glucose uptake rate and G6P concentrations to normal levels.	Glucose-6-Phosphate	122-125	insulin	Homo sapiens	11-18
1556176-11	1992	Increasing insulin concentrations to insulin 8,500 pmol/liter in four NIDDM subjects restored the glucose uptake rate and G6P concentrations to normal levels.	Glucose-6-Phosphate	122-125	insulin	Homo sapiens	37-44
17589155-3	1992	A dramatic reduction in the specific activities of glucose and glycogen degradative enzymes was observed (23.7 +/- 3.9%, 36.3 +/- 8.7% and 71.1 +/- 5.7% of control for citrate synthase, glucose-6-phosphate and phosphofructokinase respectively).	Glucose-6-Phosphate	186-205	citrate synthase	Homo sapiens	168-184
1309800-1	1992	In the presence of hexokinase, vesicles derived from the sarcoplasmic reticulum of skeletal muscle are able to accumulate Ca2+ in a medium containing ADP and glucose 6-phosphate.	Glucose-6-Phosphate	158-177	hexokinase 1	Homo sapiens	19-29
1541672-5	1992	The insulin-stimulated, fractional glycogen synthase activity (0.1/10 mmol liter glucose-6-phosphate) was decreased in the relatives (46.9 +/- 2.3 vs 56.4 +/- 3.2%, P less than 0.01), and there was a significant correlation between insulin-stimulated, fractional glycogen synthase activity and nonoxidative glucose metabolism in relatives (r = 0.76, P less than 0.001) and controls (r = 0.63, P less than 0.01).	Glucose-6-Phosphate	81-100	insulin	Homo sapiens	4-11
2022302-4	1991	Skeletal muscle glucose-6-phosphate concentration rose from 0.219 +/- 0.038 mumol/g (insulin alone) to 0.350 +/- 0.018, 0.440 +/- 0.020, and 0.505 +/- 0.035 mumol/g (insulin plus amylin at 50, 200, or 500 pmol.kg-1.min-1, P less than 0.01).	Glucose-6-Phosphate	16-35	islet amyloid polypeptide	Rattus norvegicus	179-185
1898033-12	1991	In addition, when diluted (dimeric) PEPC was preincubated with PEP or glucose 6-phosphate the enzyme became less sensitive to malate inhibition, while the active-site directed ligand 2-phosphoglycolate had no effect on malate inhibition.	Glucose-6-Phosphate	70-89	peptidase C	Homo sapiens	36-40
1898033-12	1991	In addition, when diluted (dimeric) PEPC was preincubated with PEP or glucose 6-phosphate the enzyme became less sensitive to malate inhibition, while the active-site directed ligand 2-phosphoglycolate had no effect on malate inhibition.	Glucose-6-Phosphate	70-89	progestagen associated endometrial protein	Homo sapiens	36-39
1910304-2	1991	Total enzyme activity measured with glucose 6-phosphate gradually increased during a 24-h insulin incubation.	Glucose-6-Phosphate	36-55	insulin	Homo sapiens	90-97
1541385-9	1992	A positive correlation was demonstrated between intracellular free glucose concentration and muscle glycogen synthase fractional velocity insulin activation (0.1 mmol/l glucose 6-phosphate: r = 0.65, p less than 0.02 and 0.0 mmol/l glucose 6-phosphate: r = 0.91, p less than 0.0001).	Glucose-6-Phosphate	169-188	insulin	Homo sapiens	138-145
1541385-9	1992	A positive correlation was demonstrated between intracellular free glucose concentration and muscle glycogen synthase fractional velocity insulin activation (0.1 mmol/l glucose 6-phosphate: r = 0.65, p less than 0.02 and 0.0 mmol/l glucose 6-phosphate: r = 0.91, p less than 0.0001).	Glucose-6-Phosphate	232-251	insulin	Homo sapiens	138-145
1541385-10	1992	In conclusion, this study indicates an important role for hyperglycaemia and elevated muscle free glucose and glucose 6-phosphate concentrations in compensating (normalizing) intracellular glucose metabolism and skeletal muscle glycogen synthase activation in Type 2 diabetes.	Glucose-6-Phosphate	110-129	glycogen synthase 1	Homo sapiens	212-245
16668606-4	1992	Based on these and related observations, we propose that the Calvin cycle supplies the C(4) mesophyll cell with (a) a putative signal (e.g. phosphorylated metabolite, amino acid) that interacts with the cytoplasmic protein synthesis event to effect the light activation of PEPC-PK and the concomitant phosphorylation of PEPC, and (b) high levels of known positive effectors (e.g. triose-phosphate, glucose-6-phosphate) that interact directly with the carboxylase.	Glucose-6-Phosphate	398-417	MLO-like protein 4	Zea mays	273-277
16668606-4	1992	Based on these and related observations, we propose that the Calvin cycle supplies the C(4) mesophyll cell with (a) a putative signal (e.g. phosphorylated metabolite, amino acid) that interacts with the cytoplasmic protein synthesis event to effect the light activation of PEPC-PK and the concomitant phosphorylation of PEPC, and (b) high levels of known positive effectors (e.g. triose-phosphate, glucose-6-phosphate) that interact directly with the carboxylase.	Glucose-6-Phosphate	398-417	MLO-like protein 4	Zea mays	320-324
1662952-2	1991	The hepatic microsomal glucose-6-phosphatase enzyme is situated inside the lumen of the endoplasmic reticulum and, for normal enzyme activity in vivo, three transport systems are needed for the substrate glucose-6-phosphate and the products phosphate and glucose.	Glucose-6-Phosphate	204-223	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	23-44
1906024-7	1991	Insulin stimulation of the glycogen synthase activity at a glucose-6-phosphate concentration of 0.1 mmol/l was absent in both obese groups, while activities increased significantly in the lean control subjects (19.6 +/- 4.2% to 45.6 +/- 6.8%, p less than 0.01).	Glucose-6-Phosphate	59-78	insulin	Homo sapiens	0-7
2003594-6	1991	D-Glucose 6-phosphate (G-6-P) and alpha-D-glucose 1,6-bisphosphate (G-1,6-P2) (inhibitors of hexokinase) increased significantly after 5 min of exercise (approximately 300% G-6-P; approximately 25% G-1,6-P2) and then decreased continuously.	Glucose-6-Phosphate	0-21	hexokinase 1	Homo sapiens	93-103
2003594-6	1991	D-Glucose 6-phosphate (G-6-P) and alpha-D-glucose 1,6-bisphosphate (G-1,6-P2) (inhibitors of hexokinase) increased significantly after 5 min of exercise (approximately 300% G-6-P; approximately 25% G-1,6-P2) and then decreased continuously.	Glucose-6-Phosphate	173-178	hexokinase 1	Homo sapiens	93-103
2003594-9	1991	It is concluded that, during the initial phase of exercise, glucose utilization is limited by phosphorylation, probably due to G-6-P-dependent inhibition of hexokinase.	Glucose-6-Phosphate	127-132	hexokinase 1	Homo sapiens	157-167
1846754-1	1991	The existence of the enzyme glucose-6-phosphatase (G6Pase) in early and term human placenta was investigated by comparing the characteristics of placental microsomal glucose 6-phosphate (G6P) hydrolytic activity and liver G6Pase.	Glucose-6-Phosphate	166-185	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	28-49
1996634-10	1991	Skeletal muscle glucose 6-phosphate concentration was significantly increased after CGRP infusion compared with insulin alone (0.540 +/- 0.052 vs. 0.219 +/- 0.038 mumol/g wet wt; P less than 0.01).	Glucose-6-Phosphate	16-35	calcitonin-related polypeptide alpha	Rattus norvegicus	84-88
1991519-2	1991	Glucose 6-phosphate dehydrogenase catalyzes the oxidation of glucose 6-phosphate, resulting in the formation of 6-phosphogluconolactone.	Glucose-6-Phosphate	61-80	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
1846754-1	1991	The existence of the enzyme glucose-6-phosphatase (G6Pase) in early and term human placenta was investigated by comparing the characteristics of placental microsomal glucose 6-phosphate (G6P) hydrolytic activity and liver G6Pase.	Glucose-6-Phosphate	166-185	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	51-57
1846754-1	1991	The existence of the enzyme glucose-6-phosphatase (G6Pase) in early and term human placenta was investigated by comparing the characteristics of placental microsomal glucose 6-phosphate (G6P) hydrolytic activity and liver G6Pase.	Glucose-6-Phosphate	51-54	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	28-49
1846754-1	1991	The existence of the enzyme glucose-6-phosphatase (G6Pase) in early and term human placenta was investigated by comparing the characteristics of placental microsomal glucose 6-phosphate (G6P) hydrolytic activity and liver G6Pase.	Glucose-6-Phosphate	51-54	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	222-228
2240201-7	1990	Because DEX increased HTGO (G-6-Pase) and not HGP (glycogenolysis + gluconeogenesis), we assume that DEX increases HTGO and GC in humans by activating G-6-Pase directly, rather than by expanding the glucose 6-phosphate pool.	Glucose-6-Phosphate	199-218	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	151-159
1832811-7	1991	The decreases in activities of phosphoglucomutase and glucokinase reduced a level of glucose 6-phosphate, which suppressed the supply of NADPH in pentose cycle, while the NADPH was consuming well for detoxification of endogenous lipid peroxides.	Glucose-6-Phosphate	85-104	glucokinase	Homo sapiens	54-65
2260114-1	1990	The effect of primaquine enantiomers on cell membranes of glucose-6-phosphate (G-6PD)-deficient erythrocytes was studied in vitro.	Glucose-6-Phosphate	58-77	glucose-6-phosphate dehydrogenase	Homo sapiens	79-84
2302399-6	1990	(4) The hydrolysis of glucose 6-phosphate by glucose-6-phosphatase is essential for the stimulation, as shown by inhibiting the glucose 6-phosphate hydrolysis with adequate concentrations of vanadate.	Glucose-6-Phosphate	22-41	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	45-66
1696143-1	1990	In the present work methods for the localization of glucose-6-phosphate and phosphoenolpyruvate residues on tissue sections by means of labeled with colloidal gold specific enzymes (glucose 6-phosphate dehydrogenase and pyruvate kinase) are described.	Glucose-6-Phosphate	52-71	glucose-6-phosphate dehydrogenase	Homo sapiens	182-215
2158253-1	1990	The increase in both glucose 6-phosphatase and hexokinase activities in brown adipose tissues of cold-exposed mice probably relates to thermogenesis by the substrate cycle between glucose 6-phosphate and glucose (Watanabe et al.	Glucose-6-Phosphate	180-199	glucose-6-phosphatase, catalytic	Mus musculus	21-42
16667849-8	1990	Glucose-6-phosphate, fructose-6-phosphate, glucose-1-phosphate, and dihydroxyacetone phosphate activated PEPC at pH 7 in the absence of glycerol, but had no effect under the other assay conditions.	Glucose-6-Phosphate	0-19	phosphoenolpyruvate carboxylase, housekeeping isozyme	Glycine max	105-109
2168325-5	1990	Glucose-6-phosphatase has been shown to comprise at least five different polypeptides, the catalytic subunit of glucose-6-phosphatase with its active site situated in the lumen of the endoplasmic reticulum; a regulatory Ca2+ binding protein; and three transport proteins, T1, T2, and T3, which respectively allow glucose-6-phosphate, phosphate, and glucose to cross the endoplasmic reticulum membrane.	Glucose-6-Phosphate	313-332	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
2168325-5	1990	Glucose-6-phosphatase has been shown to comprise at least five different polypeptides, the catalytic subunit of glucose-6-phosphatase with its active site situated in the lumen of the endoplasmic reticulum; a regulatory Ca2+ binding protein; and three transport proteins, T1, T2, and T3, which respectively allow glucose-6-phosphate, phosphate, and glucose to cross the endoplasmic reticulum membrane.	Glucose-6-Phosphate	313-332	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	112-133
2256954-0	1990	Enhanced proteolysis of glucose-6-phosphate dehydrogenase in the presence of palmitoyl coenzyme A. Palmitoyl coenzyme A at concentrations below its critical micelle concentration increases the rate of proteolysis of baker"s yeast glucose-6-phosphate dehydrogenase by proteinase A in the pH range 4-5. both glucose-6-phosphate and NADP protect glucose-6-phosphate dehydrogenase against proteolysis, but these protective effects are diminished in the presence of palmitoyl coenzyme A.	Glucose-6-Phosphate	24-43	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	230-263
2256954-0	1990	Enhanced proteolysis of glucose-6-phosphate dehydrogenase in the presence of palmitoyl coenzyme A. Palmitoyl coenzyme A at concentrations below its critical micelle concentration increases the rate of proteolysis of baker"s yeast glucose-6-phosphate dehydrogenase by proteinase A in the pH range 4-5. both glucose-6-phosphate and NADP protect glucose-6-phosphate dehydrogenase against proteolysis, but these protective effects are diminished in the presence of palmitoyl coenzyme A.	Glucose-6-Phosphate	24-43	proteinase A	Saccharomyces cerevisiae S288C	267-279
2256954-0	1990	Enhanced proteolysis of glucose-6-phosphate dehydrogenase in the presence of palmitoyl coenzyme A. Palmitoyl coenzyme A at concentrations below its critical micelle concentration increases the rate of proteolysis of baker"s yeast glucose-6-phosphate dehydrogenase by proteinase A in the pH range 4-5. both glucose-6-phosphate and NADP protect glucose-6-phosphate dehydrogenase against proteolysis, but these protective effects are diminished in the presence of palmitoyl coenzyme A.	Glucose-6-Phosphate	24-43	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	230-263
1696549-1	1990	Inositol-phosphates, glucosamine and glucose-6-phosphate blocked the effects of insulin on target protein phosphorylation in adipocytes, but the unsubstituted or sulphated derivatives of inositol or of glucose, or N-acetyl-glucosamine were without effect.	Glucose-6-Phosphate	37-56	insulin	Homo sapiens	80-87
2197090-1	1990	In the post-microsomal supernatant of pancreatic islets, prepared from fasted or fed rats, D-fructose 1-phosphate increased the activity of glucokinase by 20-30% as measured in the presence of D-glucose 6-phosphate and D-fructose 6-phosphate.	Glucose-6-Phosphate	193-214	glucokinase	Rattus norvegicus	140-151
24419911-2	1990	Nonlimiting assay conditions are obtained by either increasing the level of the coupling enzyme to 3 units/ml or adding 6mM glucose-6-phosphate as an activator/stabilizer of phosphoenolpyruvate carboxylase.	Glucose-6-Phosphate	124-143	phosphoenolpyruvate carboxykinase 1	Homo sapiens	174-205
2302399-6	1990	(4) The hydrolysis of glucose 6-phosphate by glucose-6-phosphatase is essential for the stimulation, as shown by inhibiting the glucose 6-phosphate hydrolysis with adequate concentrations of vanadate.	Glucose-6-Phosphate	128-147	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	45-66
34522206-11	2021	Depletion of KDM5C increased the production of glycogen, which was then directed to glycogenolysis to generate glucose-6-phosphate (G6P) and subsequently PPP to produce nicotinamide adenine dinucleotide phosphate hydride (NADPH) and glutathione (GSH), thus conferring cells resistance to reactive oxygen species (ROS) and ferroptosis.	Glucose-6-Phosphate	132-135	lysine demethylase 5C	Homo sapiens	13-18
2159682-6	1990	By this formula we evaluated the hepatic activities of glucose-6-phosphatase and glucokinase (which roughly reflect hepatic glucose production and uptake, respectively), i.e. the two enzymes that catalyze the cycle between glucose-6-phosphate (glucose-6-P) and glucose.	Glucose-6-Phosphate	223-242	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	55-76
2159682-6	1990	By this formula we evaluated the hepatic activities of glucose-6-phosphatase and glucokinase (which roughly reflect hepatic glucose production and uptake, respectively), i.e. the two enzymes that catalyze the cycle between glucose-6-phosphate (glucose-6-P) and glucose.	Glucose-6-Phosphate	223-242	glucokinase	Homo sapiens	81-92
2159682-6	1990	By this formula we evaluated the hepatic activities of glucose-6-phosphatase and glucokinase (which roughly reflect hepatic glucose production and uptake, respectively), i.e. the two enzymes that catalyze the cycle between glucose-6-phosphate (glucose-6-P) and glucose.	Glucose-6-Phosphate	244-255	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	55-76
2159682-6	1990	By this formula we evaluated the hepatic activities of glucose-6-phosphatase and glucokinase (which roughly reflect hepatic glucose production and uptake, respectively), i.e. the two enzymes that catalyze the cycle between glucose-6-phosphate (glucose-6-P) and glucose.	Glucose-6-Phosphate	244-255	glucokinase	Homo sapiens	81-92
33774822-2	2021	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P), which are important metabolic molecules in starch synthesis within chloroplasts and sucrose synthesis in cytosol.	Glucose-6-Phosphate	90-93	phosphoglucose isomerase 1	Arabidopsis thaliana	26-29
2306121-0	1990	Binding of nucleoside triphosphates, inorganic phosphate, and other polyanionic ligands to the N-terminal region of rat brain hexokinase: relationship to regulation of hexokinase activity by antagonistic interactions between glucose 6-phosphate and inorganic phosphate.	Glucose-6-Phosphate	225-244	hexokinase 1	Homo sapiens	126-136
2306121-0	1990	Binding of nucleoside triphosphates, inorganic phosphate, and other polyanionic ligands to the N-terminal region of rat brain hexokinase: relationship to regulation of hexokinase activity by antagonistic interactions between glucose 6-phosphate and inorganic phosphate.	Glucose-6-Phosphate	225-244	hexokinase 1	Homo sapiens	168-178
2306121-10	1990	A model depicting possible relationships between ligand binding sites on brain hexokinase, and how their interactions might lead to observed regulatory properties, is developed based on these and previous studies of ligand binding as well as evidence that mammalian hexokinases (Mr 100,000) have evolved by duplication and fusion of a gene coding for an ancestral hexokinase with Mr 50,000 and which, like the mammalian enzyme, was sensitive to inhibition by Glc-6-P.	Glucose-6-Phosphate	459-466	hexokinase 1	Homo sapiens	79-89
2306121-10	1990	A model depicting possible relationships between ligand binding sites on brain hexokinase, and how their interactions might lead to observed regulatory properties, is developed based on these and previous studies of ligand binding as well as evidence that mammalian hexokinases (Mr 100,000) have evolved by duplication and fusion of a gene coding for an ancestral hexokinase with Mr 50,000 and which, like the mammalian enzyme, was sensitive to inhibition by Glc-6-P.	Glucose-6-Phosphate	459-466	hexokinase 1	Homo sapiens	266-276
2295599-11	1990	Glucose 6-phosphate, which is known to release hexokinase from the brain "mitochondrial fraction" also releases hexokinase from this unidentified particulate component.	Glucose-6-Phosphate	0-19	hexokinase 1	Homo sapiens	47-57
2295599-11	1990	Glucose 6-phosphate, which is known to release hexokinase from the brain "mitochondrial fraction" also releases hexokinase from this unidentified particulate component.	Glucose-6-Phosphate	0-19	hexokinase 1	Homo sapiens	112-122
33774822-2	2021	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P), which are important metabolic molecules in starch synthesis within chloroplasts and sucrose synthesis in cytosol.	Glucose-6-Phosphate	90-93	phosphoglucose isomerase 1	Arabidopsis thaliana	0-24
21385794-1	2011	Glucose-6-phosphatase, an enzyme localized in the endoplasmic reticulum (ER), catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	127-130	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	Glucose-6-Phosphate	116-119	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	48-53
34476741-10	2021	A high rate of aerobic glycolysis is induced by c-MYC, increasing the amounts of intracellular Glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glyceraldehyde-3-phosphate (GA3P), which can all enter pentose phosphate pathway (PPP) to produce Ribose-5-Phosphate (R5P) and NADPH, which are necessary for the biosynthesis of biomolecules such as proteins, nucleic acids, or lipids.	Glucose-6-Phosphate	116-119	2,4-dienoyl-CoA reductase 1	Homo sapiens	281-286
34105559-3	2021	Here, we combine infrequent metadynamics (InMetaD), umbrella sampling (US), and kinetic Monte Carlo (KMC) models to computationally study the transfer mechanism of glucose-6-phosphate (G6P) on a poly-arginine peptide bridging hexokinase (HK) and glucose-6-dehydrogenase (G6PDH).	Glucose-6-Phosphate	185-188	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	271-276
35433171-1	2022	Glycogen storage disease type 1b (GSD 1b) is an inherited metabolic defect caused by biallelic mutations in the SLC37A4 gene encoding microsomal glucose-6-phosphate (G6P) transporter in the endoplasmic reticulum (ER) membrane.	Glucose-6-Phosphate	166-169	solute carrier family 37 member 4	Homo sapiens	34-40
35176280-2	2022	G6PC2 is predominantly expressed in islets, encodes a glucose-6-phosphatase catalytic subunit that converts glucose-6-phosphate (G6P) to glucose, and has been linked with variations in FBG in genome-wide association studies.	Glucose-6-Phosphate	129-132	glucose-6-phosphatase, catalytic, 2	Mus musculus	0-5
35620924-1	2022	Glycogen storage disease type 1b (GSD 1b) is an inherited metabolic defect caused by a deficiency of microsomal glucose-6-phosphate (G6P) transport protein across the endoplasmic reticulum membrane.	Glucose-6-Phosphate	133-136	solute carrier family 37 member 4	Homo sapiens	34-40
35433171-1	2022	Glycogen storage disease type 1b (GSD 1b) is an inherited metabolic defect caused by biallelic mutations in the SLC37A4 gene encoding microsomal glucose-6-phosphate (G6P) transporter in the endoplasmic reticulum (ER) membrane.	Glucose-6-Phosphate	166-169	solute carrier family 37 member 4	Homo sapiens	112-119
18964821-2	1989	This method is suitable for coupling to enzyme-catalysed dehydrogenation reactions and thus for the determination of glucose-6-phosphate with glucose-6-phosphate dehydrogenase and of glucose with the combined ATP/hexokinase/glucose-6-phosphate dehydrogenase system, even with the use of immobilized mediators.	Glucose-6-Phosphate	117-136	glucose-6-phosphate dehydrogenase	Homo sapiens	142-175
35207558-3	2022	Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping protein with 514 amino acids that is also the rate-limiting enzyme of PPP, catalyzing G6P into 6-phosphogluconolactone (6PGL) and producing the first NADPH of this pathway.	Glucose-6-Phosphate	145-148	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
35207558-3	2022	Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping protein with 514 amino acids that is also the rate-limiting enzyme of PPP, catalyzing G6P into 6-phosphogluconolactone (6PGL) and producing the first NADPH of this pathway.	Glucose-6-Phosphate	145-148	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
2554805-8	1989	(v) Glucose 6-phosphate hydrolysis of the partially purified glucose-6-phosphatase is also inhibited as observed with native microsomes.	Glucose-6-Phosphate	4-23	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	61-82
18964821-2	1989	This method is suitable for coupling to enzyme-catalysed dehydrogenation reactions and thus for the determination of glucose-6-phosphate with glucose-6-phosphate dehydrogenase and of glucose with the combined ATP/hexokinase/glucose-6-phosphate dehydrogenase system, even with the use of immobilized mediators.	Glucose-6-Phosphate	117-136	hexokinase 1	Homo sapiens	213-223
18964821-2	1989	This method is suitable for coupling to enzyme-catalysed dehydrogenation reactions and thus for the determination of glucose-6-phosphate with glucose-6-phosphate dehydrogenase and of glucose with the combined ATP/hexokinase/glucose-6-phosphate dehydrogenase system, even with the use of immobilized mediators.	Glucose-6-Phosphate	117-136	glucose-6-phosphate dehydrogenase	Homo sapiens	224-257
2725285-3	1989	The activation of glycogen phosphorylase caused the mobilization of glycogen and increased the cellular concentration of hexose 6-phosphates (glucose 6-phosphate plus fructose 6-phosphate) and that of fructose 2,6-bisphosphate.	Glucose-6-Phosphate	142-161	glycogen phosphorylase L	Rattus norvegicus	18-40
2917560-1	1989	At a concentration of 1 mM, fructose 1-phosphate stimulated about twofold, and glucose 6-phosphate inhibited by about 30%, the phosphorylation of 5 mM glucose in high-speed supernatants prepared from rat liver or from isolated hepatocytes, but did not affect, or barely so, the activity of a partially purified preparation of glucokinase.	Glucose-6-Phosphate	79-98	glucokinase	Rattus norvegicus	326-337
2523728-9	1989	They also provide minimal estimates of 350 and 150 s-1 for the rate constants describing (PO3-) transfer from the Cd2+ phosphoenzyme to the 6-position of bound glucose 1-phosphate and to the 1-position of bound glucose 6-phosphate, respectively.	Glucose-6-Phosphate	211-230	CD2 molecule	Homo sapiens	114-117
3170594-0	1988	Brain hexokinase has no preexisting allosteric site for glucose 6-phosphate.	Glucose-6-Phosphate	56-75	hexokinase 1	Homo sapiens	6-16
2848837-2	1988	Significant dephosphorylation of glucose 6-phosphate due to glucose-6-phosphatase activity in rat brain in vivo was recently reported (Huang, M., and Veech, R.L.	Glucose-6-Phosphate	33-52	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	60-81
2848837-9	1988	These deficiencies in the isolation procedures could fully account for the observations that were interpreted as evidence of significant glucose 6-phosphate dephosphorylation by glucose-6-phosphatase activity.	Glucose-6-Phosphate	137-156	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	178-199
3170594-1	1988	Difference spectroscopic investigations on the interaction of brain hexokinase with glucose and glucose 6-phosphate (Glc-6-P) show that the binary complexes E-glucose and E-Glc-6-P give very similar UV difference spectra.	Glucose-6-Phosphate	96-115	hexokinase 1	Homo sapiens	68-78
3170594-1	1988	Difference spectroscopic investigations on the interaction of brain hexokinase with glucose and glucose 6-phosphate (Glc-6-P) show that the binary complexes E-glucose and E-Glc-6-P give very similar UV difference spectra.	Glucose-6-Phosphate	117-124	hexokinase 1	Homo sapiens	68-78
3170594-3	1988	Direct binding studies of the interaction of Glc-6-P with brain hexokinase detect only a single high-affinity binding site for Glc-6-P (KD = 2.8 microM).	Glucose-6-Phosphate	45-52	hexokinase 1	Homo sapiens	64-74
3170594-3	1988	Direct binding studies of the interaction of Glc-6-P with brain hexokinase detect only a single high-affinity binding site for Glc-6-P (KD = 2.8 microM).	Glucose-6-Phosphate	127-134	hexokinase 1	Homo sapiens	64-74
3170594-7	1988	Scatchard plots of the binding of glucose to brain hexokinase reveal only a single binding site but show distinct evidence of positive cooperativity, which is abolished by Glc-6-P and Pi.	Glucose-6-Phosphate	172-179	hexokinase 1	Homo sapiens	51-61
3170594-11	1988	We also discuss the possibility that, in the absence of glucose, Glc-6-P may still bind to the allosteric site, but with very low affinity, as has been observed in studies on the reverse hexokinase reaction.	Glucose-6-Phosphate	65-72	hexokinase 1	Homo sapiens	187-197
2974722-3	1988	When equimolar amounts of N6P and GBP were incubated together with PGM, the GBP was quantitatively converted to glucose 6-phosphate (G6P) and phosphate.	Glucose-6-Phosphate	112-131	phosphoglucomutase-1	Oryctolagus cuniculus	67-70
3066123-6	1988	Glucagon increased the activity of glucose 6-phosphate (EC 3.1.3.9) (G6Pase) in the presence or absence of insulin, while insulin had no effects on the levels of G6Pase and fructose 1,6-bisphosphatase (EC 3.1.3.11) in the presence or absence of glucagon.	Glucose-6-Phosphate	35-54	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	69-75
2974722-3	1988	When equimolar amounts of N6P and GBP were incubated together with PGM, the GBP was quantitatively converted to glucose 6-phosphate (G6P) and phosphate.	Glucose-6-Phosphate	133-136	phosphoglucomutase-1	Oryctolagus cuniculus	67-70
16666257-12	1988	Such a decrease in glucose 6-phosphate concentration could permit an increased control of phosphoenolpyruvate carboxylase by energy charge during the day.	Glucose-6-Phosphate	19-38	phosphoenolpyruvate carboxykinase 1	Homo sapiens	90-121
3259434-1	1988	Glucose 6-phosphate as well as several other hexose mono- and diphosphates were found by kinetic studies to be competitive inhibitors of human hexokinase I (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) versus MgATP.	Glucose-6-Phosphate	0-19	hexokinase 1	Homo sapiens	143-155
2836385-0	1988	The glucose-6-phosphatase system in rat hepatic microsomes displays hyperbolic kinetics at physiological glucose 6-phosphate concentrations.	Glucose-6-Phosphate	105-124	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	4-25
3259434-1	1988	Glucose 6-phosphate as well as several other hexose mono- and diphosphates were found by kinetic studies to be competitive inhibitors of human hexokinase I (ATP:D-hexose 6-phosphotransferase, EC 2.7.1.1) versus MgATP.	Glucose-6-Phosphate	0-19	hexokinase 3	Homo sapiens	157-190
3259434-4	1988	Addition of glucose 6-phosphate to the MgATP-hexokinase complex at a concentration 100-times higher than its Ki was not able to reverse the MgATP-induced conformation of hexokinase, suggesting that the binding of glucose 6-phosphate and MgATP are not mutually exclusive.	Glucose-6-Phosphate	12-31	hexokinase 1	Homo sapiens	45-55
3259434-4	1988	Addition of glucose 6-phosphate to the MgATP-hexokinase complex at a concentration 100-times higher than its Ki was not able to reverse the MgATP-induced conformation of hexokinase, suggesting that the binding of glucose 6-phosphate and MgATP are not mutually exclusive.	Glucose-6-Phosphate	213-232	hexokinase 1	Homo sapiens	45-55
3259434-5	1988	Similar evidence was also obtained by studies of the induced modifications of ultraviolet spectra of hexokinase by the binding of MgATP, glucose 6-phosphate and both compounds.	Glucose-6-Phosphate	137-156	hexokinase 1	Homo sapiens	101-111
3259434-6	1988	Among a library of monoclonal antibodies produced against rat brain hexokinase I and that recognize human placenta hexokinase I, one (4A6) was found to be able to modify the Ki of glucose 6-phosphate (from 25 to 140 microM) for human hexokinase I.	Glucose-6-Phosphate	180-199	hexokinase 1	Homo sapiens	68-80
3259434-6	1988	Among a library of monoclonal antibodies produced against rat brain hexokinase I and that recognize human placenta hexokinase I, one (4A6) was found to be able to modify the Ki of glucose 6-phosphate (from 25 to 140 microM) for human hexokinase I.	Glucose-6-Phosphate	180-199	hexokinase 1	Homo sapiens	115-127
3259434-6	1988	Among a library of monoclonal antibodies produced against rat brain hexokinase I and that recognize human placenta hexokinase I, one (4A6) was found to be able to modify the Ki of glucose 6-phosphate (from 25 to 140 microM) for human hexokinase I.	Glucose-6-Phosphate	180-199	hexokinase 1	Homo sapiens	115-127
2850643-2	1988	(1984) for the measurement of glucose 6-phosphate uptake by the microsomes has been demonstrated to be a good method for assaying glucose-6-phosphate translocase, an obligatory component of the microsomal glucose-6-phosphatase system.	Glucose-6-Phosphate	30-49	solute carrier family 37 member 4	Rattus norvegicus	130-161
2836867-1	1988	Glucose-6-phosphate dehydrogenase (G6PD; D-glucose-6-phosphate:NADP+ oxidoreductase, EC 1.1.1.49) A(-) is a common variant in Blacks that causes sensitivity to drug-and infection-induced hemolytic anemia.	Glucose-6-Phosphate	41-62	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
2836867-1	1988	Glucose-6-phosphate dehydrogenase (G6PD; D-glucose-6-phosphate:NADP+ oxidoreductase, EC 1.1.1.49) A(-) is a common variant in Blacks that causes sensitivity to drug-and infection-induced hemolytic anemia.	Glucose-6-Phosphate	41-62	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
2836867-1	1988	Glucose-6-phosphate dehydrogenase (G6PD; D-glucose-6-phosphate:NADP+ oxidoreductase, EC 1.1.1.49) A(-) is a common variant in Blacks that causes sensitivity to drug-and infection-induced hemolytic anemia.	Glucose-6-Phosphate	41-62	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	69-83
2850643-2	1988	(1984) for the measurement of glucose 6-phosphate uptake by the microsomes has been demonstrated to be a good method for assaying glucose-6-phosphate translocase, an obligatory component of the microsomal glucose-6-phosphatase system.	Glucose-6-Phosphate	30-49	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	205-226
3355174-6	1988	The steady-state kinetics of crude and purified erythrocyte glucose-6-phosphate dehydrogenase are reported here at various temperatures, ionic strengths, and pH values and as a function of glucose 6-phosphate concentration.	Glucose-6-Phosphate	189-208	glucose-6-phosphate dehydrogenase	Homo sapiens	60-93
2836198-7	1988	(d) Preincubation of native microsomes or partially purified glucose-6-phosphatase with a 3000-fold excess of glucose 6-phosphate cannot prevent the DIDS-induced inhibition.	Glucose-6-Phosphate	110-129	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	61-82
16666161-1	1988	The binding of phosphoenolpyruvate, malate, and glucose 6-phosphate to phosphoenolpyruvate carboxylase purified from Crassula argentea Thunb.	Glucose-6-Phosphate	48-67	phosphoenolpyruvate carboxykinase 1	Homo sapiens	71-102
3358935-2	1988	In this sequence, hexokinase is inhibited by its product glucose 6-phosphate and also by D-gluconic acid produced from the parallel enzymic reaction of glucose oxidase.	Glucose-6-Phosphate	57-76	hexokinase 1	Homo sapiens	18-28
3355174-9	1988	High concentrations of glucose 6-phosphate and factors favoring the enzyme in the dimeric form are necessary conditions for the observation of sigmoid kinetics in human erythrocyte glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	23-42	glucose-6-phosphate dehydrogenase	Homo sapiens	181-214
3065719-1	1988	In type 1 glycogen storage diseases, glucose-6-phosphatase may be present but associated with impaired transport of glucose-6-phosphate (type 1b) or inorganic phosphate (type 1c) through microsomal membranes.	Glucose-6-Phosphate	116-135	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	37-58
16666121-8	1988	This suggests a stimulation of the release of C-1 as CO(2) at the level of the glucose 6-phosphate oxidation pathway, as expected if NADPH was the electron donor for ferricyanide reduction.	Glucose-6-Phosphate	79-98	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	46-49
3352744-6	1988	We have cloned the gene for pig muscle phosphohexose isomerase (PHI) (EC 5.3.1.9) which catalyses the conversion of glucose-6-phosphate to fructose-6-phosphate, an obligatory step in glycolysis, and determined its amino-acid sequence.	Glucose-6-Phosphate	116-135	glucose-6-phosphate isomerase	Homo sapiens	39-62
3352744-6	1988	We have cloned the gene for pig muscle phosphohexose isomerase (PHI) (EC 5.3.1.9) which catalyses the conversion of glucose-6-phosphate to fructose-6-phosphate, an obligatory step in glycolysis, and determined its amino-acid sequence.	Glucose-6-Phosphate	116-135	glucose-6-phosphate isomerase	Sus scrofa	64-67
3281661-14	1988	Infusion of the lipoprotein lipase inhibitor, Triton WR1339, abolished the suppression of mammary-gland lipogenesis by triolein and the increase in the [glucose 6-phosphate]/[fructose 1,6-bisphosphate] ratio, suggesting a direct influence of dietary lipid on mammary-gland glucose utilization and phosphofructokinase activity.	Glucose-6-Phosphate	153-172	lipoprotein lipase	Rattus norvegicus	16-34
2962852-5	1988	4) Insulin treatment of the cells caused activation of the enzyme glycogen synthase from a glucose-6-phosphate-dependent form to an independent form.	Glucose-6-Phosphate	91-110	insulin	Bos taurus	3-10
3366651-4	1988	Next, exogenous and endogenous hexokinase catalyses the reaction between ATP and D-glucose to yield D-glucose-6-phosphate and ADP.	Glucose-6-Phosphate	100-121	hexokinase 1	Homo sapiens	31-41
3319615-8	1987	Even at adenine nucleotide concentrations far below the Km of hexokinase, substantial amounts of glucose 6-phosphate were produced when the enzymes were near but not when they were distant.	Glucose-6-Phosphate	97-116	hexokinase 1	Homo sapiens	62-72
3043440-11	1988	It is also easy to imagine that in diabetes when the islets are chronically exposed to high glucose that, as a result of the content of the high Km glucokinase in the islet (Meglasson and Matschinsky, 1986), higher concentrations of glucose 6-phosphate may be achieved.	Glucose-6-Phosphate	233-252	glucokinase	Homo sapiens	148-159
3435491-8	1987	Furthermore, glucose 6-phosphate and glucose in the medium differed with regard to the distribution of 14C between C-1 and C-6.	Glucose-6-Phosphate	13-32	complement C6	Rattus norvegicus	115-126
3502865-0	1987	[Screening for glucose-6-phosphate (G-6-PD) deficiency in the Chinese newborns and the correlation between infants with G-6-PD deficiency and their parents" nativities].	Glucose-6-Phosphate	15-34	glucose-6-phosphate dehydrogenase	Homo sapiens	36-42
3440115-1	1987	Using ion-exchange chromatography of sucrose phosphates on Dowex-1, it was demonstrated that the highly purified rat liver transketolase (specific activity 1.7 mumol/min.mg protein) is capable of catalyzing the synthesis of erythrose-4-phosphate, a metabolite of the pentose phosphate pathway non-oxidizing step, from the initial participants of glycolysis, i. e., glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	365-384	transketolase	Rattus norvegicus	123-136
3440115-6	1987	The transketolase reaction provides for the relationship between glycolysis and the anaerobic step of the pentose phosphate pathway which share common metabolites, i. e. glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	170-189	transketolase	Rattus norvegicus	4-17
3450105-6	1987	Purified GDH was inhibited by p-chloromercuribenzoate and glucose 6-phosphate.	Glucose-6-Phosphate	58-77	glucose dehydrogenase	Bos taurus	9-12
3038860-0	1987	The kinetics of intact microsome glucose-6-phosphatase are sigmoid at physiologic glucose 6-phosphate concentrations.	Glucose-6-Phosphate	82-101	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	33-54
3593443-7	1987	On the other hand, the antimetabolite 6-aminonicotinamide produced an accumulation of glucose-6-phosphate which caused an increase in the soluble hexokinase activity.	Glucose-6-Phosphate	86-105	hexokinase 1	Homo sapiens	146-156
3473475-1	1987	The hexose transport system of a fibroblast mutant, DS7, unable to convert glucose 6-phosphate to fructose 6-phosphate ("the phosphoglucose isomerase mutant"), is subject to a specific down-regulation ("curb") evoked by only glucose or D-allose.	Glucose-6-Phosphate	75-94	glucose-6-phosphate isomerase	Homo sapiens	125-149
3555157-1	1987	Methods for 2-deoxyglucose (2-DG) and 2-deoxyglucose 6-phosphate (DG6P) are described which are based on the fact that DG6P is oxidized by glucose-6-phosphate dehydrogenase (G6PDH), but at a rate 1000-fold slower than for glucose 6-phosphate, whereas hexokinase phosphorylates 2DG and glucose at comparable rates.	Glucose-6-Phosphate	45-64	glucose-6-phosphate dehydrogenase	Homo sapiens	139-172
3555157-1	1987	Methods for 2-deoxyglucose (2-DG) and 2-deoxyglucose 6-phosphate (DG6P) are described which are based on the fact that DG6P is oxidized by glucose-6-phosphate dehydrogenase (G6PDH), but at a rate 1000-fold slower than for glucose 6-phosphate, whereas hexokinase phosphorylates 2DG and glucose at comparable rates.	Glucose-6-Phosphate	45-64	glucose-6-phosphate dehydrogenase	Homo sapiens	174-179
3813560-8	1987	Glucokinase was assayed either by allowing glucose 6-phosphate to accumulate over 10 min (discontinuous assay) or by coupling the formation of glucose 6-phosphate with its oxidation by Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase and NAD (continuous assay).	Glucose-6-Phosphate	43-62	glucokinase	Rattus norvegicus	0-11
3813560-8	1987	Glucokinase was assayed either by allowing glucose 6-phosphate to accumulate over 10 min (discontinuous assay) or by coupling the formation of glucose 6-phosphate with its oxidation by Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase and NAD (continuous assay).	Glucose-6-Phosphate	143-162	glucokinase	Rattus norvegicus	0-11
3813560-12	1987	The discontinuous assay as used previously (Alvares and Nordlie) underestimates glucokinase activity in crude extracts by 2- to 2.5-fold, due in part to the hydrolysis of glucose 6-phosphate and its transformation to other hexose monophosphates.	Glucose-6-Phosphate	171-190	glucokinase	Rattus norvegicus	80-91
2819807-1	1987	The synthesis of uridine diphosphate glucose (UDPG), cytidine diphosphate choline (CDP-choline), glucose-1-phosphate (G1P) and glucose-6-phosphate (G6P) has been accomplished under simulated prebiotic conditions using urea and cyanamide, two condensing agents considered to have been present on the primitive Earth.	Glucose-6-Phosphate	148-151	UDP-glucose pyrophosphorylase 2	Homo sapiens	17-44
2448471-7	1987	In addition, we have shown that the purified protein, when reconstituted into liposomes, can bind hexokinase in a glucose-6-phosphate dependent manner, as has been shown for VDAC purified from other sources.	Glucose-6-Phosphate	114-133	hexokinase	Saccharomyces cerevisiae S288C	98-108
2448471-7	1987	In addition, we have shown that the purified protein, when reconstituted into liposomes, can bind hexokinase in a glucose-6-phosphate dependent manner, as has been shown for VDAC purified from other sources.	Glucose-6-Phosphate	114-133	porin	Drosophila melanogaster	174-178
3322272-4	1987	Hepatic glucose production appears in later stages because of the low activity of glucose 6-phosphatase as demonstrated by the effect of glucagon on the hepatic glucose 6-phosphate concentration.	Glucose-6-Phosphate	161-180	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	82-103
3622907-6	1987	A contributive role for aldose reductase in the anomeric control of D-glucose 6-phosphate circulation in the pentose phosphate pathway should not be ruled out, since aldose reductase inhibitors decrease the production of 14CO2 by erythrocytes exposed to D-[U-14C]glucose.	Glucose-6-Phosphate	68-89	aldo-keto reductase family 1 member B	Homo sapiens	24-40
3309140-2	1987	Metabolite analyses showed accumulation of glucose 6-phosphate in a cdc30-bearing strain after a temperature shift-up in glucose-containing medium.	Glucose-6-Phosphate	43-62	glucose-6-phosphate isomerase	Saccharomyces cerevisiae S288C	68-73
16665142-7	1986	While the in vitro phosphorylation of PEPCase from illuminated maize leaves by an endogenous protein kinase resulted in a partial inactivation ( approximately 25%) of the enzyme when assayed at pH 7 and subsaturating levels of PEP, effector modulation by l-malate and glucose-6-phosphate was relatively unaffected.	Glucose-6-Phosphate	268-287	MLO-like protein 4	Zea mays	38-45
3023336-12	1986	Overall, our analysis suggests that glucose enhances the metabolic flux to glycogen by inducing a build up of glucose 6-phosphate via combined effects of mass action and glucose-6-phosphatase inhibition and activating glycogen synthase and that fructose enhances glycogen accumulation by retaining glycogen via phosphorylase inhibition.	Glucose-6-Phosphate	110-129	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	170-191
3023346-8	1986	The glucose 6-phosphate increase in the ATP-dependent Ca2+ content of the ER was shown to be mediated by glucose 6-phosphatase localized to the ER.	Glucose-6-Phosphate	4-23	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	105-126
3811284-1	1986	Glycosylation of human blood serum albumin was carried out by means of prolonged incubation of the protein with an excess of D-glucose or D-glucose-6-phosphate.	Glucose-6-Phosphate	138-159	albumin	Homo sapiens	29-42
3021149-4	1986	In the present study, 5 X 10(-6) M dexamethasone induced a tenfold increase in glucose 6-phosphatase activity in "intact" as well as disrupted microsomes using either glucose 6-phosphate or mannose 6-phosphate as substrate.	Glucose-6-Phosphate	167-186	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	79-100
3099794-4	1986	Since glucose-6-phosphate alone does not prevent the inactivation by DEPC, it is concluded that it is effective through a potentiation of the effects of UDPG, possibly through a conformational change of the enzyme.	Glucose-6-Phosphate	6-25	UDP-glucose pyrophosphorylase 2	Homo sapiens	153-157
3022618-7	1986	The results suggest that the role of the increased G6Pase in skeletal muscle cells of starved mice is to release glucose into the blood by hydrolyzing glucose 6-phosphate produced through the increased phosphorylase activity.	Glucose-6-Phosphate	151-170	glucose-6-phosphatase, catalytic	Mus musculus	51-57
3026318-6	1986	10-15% of the inhibition of gluconeogenesis observed in the presence of Rp-cAMPS was due to conversion of glucose 6-phosphate to liver glycogen, consistent with Rp-cAMPS-induced reactivation of glycogen synthase.	Glucose-6-Phosphate	106-125	calmodulin 2, pseudogene 1	Rattus norvegicus	75-80
3026341-0	1986	Antagonistic regulation of the glucose/glucose 6-phosphate cycle by insulin and glucagon in cultured hepatocytes.	Glucose-6-Phosphate	39-58	insulin	Homo sapiens	68-75
3094533-7	1986	In perfused rat liver the C-1/C-3 constants in Glc 6-P and glycogen also failed to conform with F-PC theory following the metabolism of [2-14C]Glc.	Glucose-6-Phosphate	47-54	complement C3	Rattus norvegicus	26-33
3711719-3	1986	We have now investigated the reverse G-6-PD reaction, namely, the oxidation of reduced nicotinamide-adenine dinucleotide phosphate (NADPH) by 6-phosphoglucono-delta-lactone to form glucose-6-phosphate and nicotinamide-adenine dinucleotide phosphate (NADP).	Glucose-6-Phosphate	181-200	glucose-6-phosphate dehydrogenase	Homo sapiens	37-43
3711719-9	1986	Glucose-6-phosphate was found to be a competitive inhibitor with both lactones in the reverse G-6-PD reaction.	Glucose-6-Phosphate	0-19	glucose-6-phosphate dehydrogenase	Homo sapiens	94-100
3711719-10	1986	Genetic mutants of humans in which the Km of G-6-PD for glucose-6-phosphate was diminished also had a diminished Km for 6-phosphoglucono-delta-lactone.	Glucose-6-Phosphate	56-75	glucose-6-phosphate dehydrogenase	Homo sapiens	45-51
16664876-2	1986	In addition, sensitivity to effectors of PEP carboxylase activity was significantly altered; e.g. malate inhibition was reduced and glucose-6-phosphate activation was increased.	Glucose-6-Phosphate	132-151	phosphoenolpyruvate carboxylase 2	Zea mays	41-44
3087853-1	1986	Insulin binds to its specific cell surface receptor in cultured human fibroblasts and also stimulates the conversion of glycogen synthase from the glucose-6-phosphate (G-6-P) dependent to the G-6-P independent form.	Glucose-6-Phosphate	147-166	insulin	Homo sapiens	0-7
3087853-1	1986	Insulin binds to its specific cell surface receptor in cultured human fibroblasts and also stimulates the conversion of glycogen synthase from the glucose-6-phosphate (G-6-P) dependent to the G-6-P independent form.	Glucose-6-Phosphate	168-173	insulin	Homo sapiens	0-7
3087853-1	1986	Insulin binds to its specific cell surface receptor in cultured human fibroblasts and also stimulates the conversion of glycogen synthase from the glucose-6-phosphate (G-6-P) dependent to the G-6-P independent form.	Glucose-6-Phosphate	192-197	insulin	Homo sapiens	0-7
3006788-0	1986	Comparative reactivity of carbamyl phosphate and glucose 6-phosphate with the glucose-6-phosphatase of intact microsomes.	Glucose-6-Phosphate	49-68	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	78-99
3006788-1	1986	The ability of glucose 6-phosphate and carbamyl phosphate to serve as substrates for glucose-6-phosphatase (D-glucose-6-phosphate phosphohydrolase; EC 3.1.3.9) of intact and disrupted microsomes from rat liver was compared at pH 7.0.	Glucose-6-Phosphate	15-34	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	85-106
3026341-7	1986	In conclusion, under basic conditions without added hormones the glucose/glucose 6-phosphate cycle showed only a minor net glucose uptake, of 0.03 mumol/min per g of hepatocytes; this flux was increased by insulin to a net glucose uptake of 0.21 mumol/min per g and reversed by glucagon to a net glucose release of 0.22 mumol/min per g. Since the glucose 6-phosphate concentrations after hormone treatment did not correlate with the glucose-6-phosphatase flux, it is suggested that the hormones influenced the enzyme activity directly.	Glucose-6-Phosphate	73-92	insulin	Homo sapiens	206-213
3026341-7	1986	In conclusion, under basic conditions without added hormones the glucose/glucose 6-phosphate cycle showed only a minor net glucose uptake, of 0.03 mumol/min per g of hepatocytes; this flux was increased by insulin to a net glucose uptake of 0.21 mumol/min per g and reversed by glucagon to a net glucose release of 0.22 mumol/min per g. Since the glucose 6-phosphate concentrations after hormone treatment did not correlate with the glucose-6-phosphatase flux, it is suggested that the hormones influenced the enzyme activity directly.	Glucose-6-Phosphate	73-92	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	433-454
3026341-7	1986	In conclusion, under basic conditions without added hormones the glucose/glucose 6-phosphate cycle showed only a minor net glucose uptake, of 0.03 mumol/min per g of hepatocytes; this flux was increased by insulin to a net glucose uptake of 0.21 mumol/min per g and reversed by glucagon to a net glucose release of 0.22 mumol/min per g. Since the glucose 6-phosphate concentrations after hormone treatment did not correlate with the glucose-6-phosphatase flux, it is suggested that the hormones influenced the enzyme activity directly.	Glucose-6-Phosphate	347-366	insulin	Homo sapiens	206-213
3018177-5	1986	A lead-capture method was used to localize G6Pase activity with glucose-6-phosphate or mannose-6-phosphate as substrate.	Glucose-6-Phosphate	64-83	glucose-6-phosphatase, catalytic	Mus musculus	43-49
3018177-6	1986	Cerebral G6Pase functions predominantly as a phosphohydrolase to convert glucose-6-phosphate to glucose.	Glucose-6-Phosphate	73-92	glucose-6-phosphatase, catalytic	Mus musculus	9-15
3949357-2	1986	The polymorphism of G-6-PD was investigated in different regions of Saudi Arabia, and G-6-PD variants were separated and identified on the basis of their electrophoretic mobility and activity towards glucose-6-phosphate.	Glucose-6-Phosphate	200-219	glucose-6-phosphate dehydrogenase	Homo sapiens	86-92
3904982-2	1985	The hexokinase-like enzyme was inhibited by glucose 6-phosphate and displayed a greater affinity for but lower maximal velocity with alpha-D-glucose than beta-D-glucose.	Glucose-6-Phosphate	44-63	hexokinase 1	Homo sapiens	4-14
3930326-1	1985	Human aorta, brain, and muscle aldose reductase, partially purified by DEAE-cellulose (DE-52) column chromatography, is activated 2-2.5-fold on incubation with 10 microM each of glucose-6-phosphate, NADPH, and glucose for 20 min at 25 degrees C. The activation of the enzyme was established by following the NADPH oxidation as well as the sorbitol formation using glucose as substrate.	Glucose-6-Phosphate	178-197	aldo-keto reductase family 1 member B	Homo sapiens	31-47
3932573-4	1985	We constructed an artificial hexose monophosphate pathway from these enzymes, providing as substrate 14C-labeled glucose-6-phosphate either directly or by continual generation from 14C-glucose by yeast hexokinase and adenosine triphosphate.	Glucose-6-Phosphate	113-132	hexokinase	Saccharomyces cerevisiae S288C	202-212
24240961-5	1985	However, NADPH alone did not serve as an electron donor for nitrite reduction, although NADPH with Glc6P added was effective.	Glucose-6-Phosphate	99-104	2,4-dienoyl-CoA reductase 1	Homo sapiens	88-93
2990572-5	1985	Addition of ADP to well-coupled mitochondria in the presence of an oxidizable substrate initiates the synthesis of glucose 6-phosphate via bound hexokinase.	Glucose-6-Phosphate	115-134	hexokinase 1	Homo sapiens	145-155
4031071-5	1985	The difference between the Ra determined by 2-D1-glucose (Ra2) and the Ra determined by 3-D1-glucose (Ra3) represents the substrate cycling rate (SCR) between glucose and glucose-6-phosphate.	Glucose-6-Phosphate	171-190	RA2	Homo sapiens	58-61
4031071-5	1985	The difference between the Ra determined by 2-D1-glucose (Ra2) and the Ra determined by 3-D1-glucose (Ra3) represents the substrate cycling rate (SCR) between glucose and glucose-6-phosphate.	Glucose-6-Phosphate	171-190	RA3	Homo sapiens	102-105
4016133-0	1985	Isolation and glucose-6-phosphate-mediated dimerization of hexokinase from human heart.	Glucose-6-Phosphate	14-33	hexokinase 1	Homo sapiens	59-69
4019261-6	1985	Although the three subjects with low levels of D-glucose 6-phosphate: NADP 1-oxidoreductase EC 1.1.1.49 (G6P-D) had, as expected, correspondingly low AC"s of EGR, their unsupplemented activities of PPO were in the same low range as those of the G6P-D-normal subjects, and they responded as G6P-D-normal subjects did to riboflavin supplementation.	Glucose-6-Phosphate	47-68	glucose-6-phosphate dehydrogenase	Homo sapiens	105-110
4005852-10	1985	A dramatic stimulation (35 to 40 times over untreated controls) was produced by Aroclor 1254, which also coinduced the liver cytosolic activity of enzymes involved in the glucose 6-phosphate-dependent pathway of both nicotinamide-adenine-dinucleotide phosphate and glutathione reduction (glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase).	Glucose-6-Phosphate	171-190	glucose-6-phosphate dehydrogenase	Rattus norvegicus	288-321
4005852-10	1985	A dramatic stimulation (35 to 40 times over untreated controls) was produced by Aroclor 1254, which also coinduced the liver cytosolic activity of enzymes involved in the glucose 6-phosphate-dependent pathway of both nicotinamide-adenine-dinucleotide phosphate and glutathione reduction (glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase).	Glucose-6-Phosphate	171-190	glutathione-disulfide reductase	Rattus norvegicus	361-382
2987273-7	1985	Comparisons of the mannose-6-phosphatase and glucose-6-phosphatase activities demonstrated that 5-10 U/ml alpha-toxin rendered cells freely permeable to glucose-6-phosphate, while substantially preserving the selective permeability of the membranes of the endoplasmic reticulum and the functionality of the glucose-6-phosphatase system.	Glucose-6-Phosphate	153-172	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	45-66
2988615-10	1985	In the system for the glucose 6-phosphate-stimulated calcium uptake, glucose 6-phosphate is actively hydrolyzed by the glucose-6-phosphatase activity of liver microsomes.	Glucose-6-Phosphate	22-41	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	119-140
2988615-10	1985	In the system for the glucose 6-phosphate-stimulated calcium uptake, glucose 6-phosphate is actively hydrolyzed by the glucose-6-phosphatase activity of liver microsomes.	Glucose-6-Phosphate	69-88	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	119-140
2988615-12	1985	Calcium uptake is maximal when the concentration of glucose 6-phosphate in the system is 1-3 mM, which is much lower than that necessary to saturate glucose-6-phosphatase.	Glucose-6-Phosphate	52-71	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	149-170
3856279-0	1985	High glucose concentrations partially release hexokinase from inhibition by glucose 6-phosphate.	Glucose-6-Phosphate	76-95	hexokinase 1	Homo sapiens	46-56
3856279-5	1985	On the contrary, in the presence of glucose 6-phosphate, hexokinase activity increased at glucose concentrations greater than 5 mM; inhibition by glucose 6-phosphate was partially competitive with glucose.	Glucose-6-Phosphate	36-55	hexokinase 1	Homo sapiens	57-67
3856279-5	1985	On the contrary, in the presence of glucose 6-phosphate, hexokinase activity increased at glucose concentrations greater than 5 mM; inhibition by glucose 6-phosphate was partially competitive with glucose.	Glucose-6-Phosphate	146-165	hexokinase 1	Homo sapiens	57-67
3856279-6	1985	The relief by glucose of glucose 6-phosphate inhibition of hexokinase is a possible explanation of the increased glucose 6-phosphate level in diabetic erythrocytes.	Glucose-6-Phosphate	25-44	hexokinase 1	Homo sapiens	59-69
3856279-6	1985	The relief by glucose of glucose 6-phosphate inhibition of hexokinase is a possible explanation of the increased glucose 6-phosphate level in diabetic erythrocytes.	Glucose-6-Phosphate	113-132	hexokinase 1	Homo sapiens	59-69
4019261-6	1985	Although the three subjects with low levels of D-glucose 6-phosphate: NADP 1-oxidoreductase EC 1.1.1.49 (G6P-D) had, as expected, correspondingly low AC"s of EGR, their unsupplemented activities of PPO were in the same low range as those of the G6P-D-normal subjects, and they responded as G6P-D-normal subjects did to riboflavin supplementation.	Glucose-6-Phosphate	47-68	protoporphyrinogen oxidase	Homo sapiens	198-201
4019261-6	1985	Although the three subjects with low levels of D-glucose 6-phosphate: NADP 1-oxidoreductase EC 1.1.1.49 (G6P-D) had, as expected, correspondingly low AC"s of EGR, their unsupplemented activities of PPO were in the same low range as those of the G6P-D-normal subjects, and they responded as G6P-D-normal subjects did to riboflavin supplementation.	Glucose-6-Phosphate	47-68	glucose-6-phosphate dehydrogenase	Homo sapiens	245-250
4019261-6	1985	Although the three subjects with low levels of D-glucose 6-phosphate: NADP 1-oxidoreductase EC 1.1.1.49 (G6P-D) had, as expected, correspondingly low AC"s of EGR, their unsupplemented activities of PPO were in the same low range as those of the G6P-D-normal subjects, and they responded as G6P-D-normal subjects did to riboflavin supplementation.	Glucose-6-Phosphate	47-68	glucose-6-phosphate dehydrogenase	Homo sapiens	245-250
2986020-1	1985	We propose the following scheme for cerebral uptake and overall metabolism of glucose in vivo: that brain selects from two pools of glucose anomers in arterial blood, that it takes up excess glucose, that glucose enters the brain tissue as glucose-6-phosphate through the actions of mutarotase and hexokinase, that some glucose-6-phosphate becomes metabolized to CO2 and some becomes incorporated into brain carbon pools, and that excess glucose-6-phosphate leaves brain through glucose-6-phosphatase and mutarotase activities.	Glucose-6-Phosphate	240-259	hexokinase 1	Homo sapiens	298-308
2986636-2	1985	Oxygen consumption by mitochondria and glucose-6-phosphate synthesis by hexokinase were registered.	Glucose-6-Phosphate	39-58	hexokinase-2	Oryctolagus cuniculus	72-82
2986020-1	1985	We propose the following scheme for cerebral uptake and overall metabolism of glucose in vivo: that brain selects from two pools of glucose anomers in arterial blood, that it takes up excess glucose, that glucose enters the brain tissue as glucose-6-phosphate through the actions of mutarotase and hexokinase, that some glucose-6-phosphate becomes metabolized to CO2 and some becomes incorporated into brain carbon pools, and that excess glucose-6-phosphate leaves brain through glucose-6-phosphatase and mutarotase activities.	Glucose-6-Phosphate	240-259	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	479-500
2986020-5	1985	Studies with [14C]glucose-6-phosphate suggested that glucose-6-phosphatase in brain removes excess substrate by dephosphorylation.	Glucose-6-Phosphate	18-37	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	53-74
6508792-3	1984	These data exclude a regulatory role of glucose 6-phosphate in the HMP even if its concentration is under that required for maximal G6PD activity.	Glucose-6-Phosphate	40-59	inner membrane mitochondrial protein	Homo sapiens	67-70
3918396-7	1985	The same dose of insulin also stimulated the glucose-6-phosphate independent form of glycogen synthase.	Glucose-6-Phosphate	45-64	insulin	Homo sapiens	17-24
4085453-4	1985	The G6PD demonstrated marked heat lability, a normal Km value for glucose-6-phosphate (56 mumol/l), a nearly normal pH-activity curve, and increased utilization of 2-deoxyglucose-6-phosphate (76% of the rate with glucose-6-phosphate).	Glucose-6-Phosphate	66-85	glucose-6-phosphate dehydrogenase	Homo sapiens	4-8
4085453-4	1985	The G6PD demonstrated marked heat lability, a normal Km value for glucose-6-phosphate (56 mumol/l), a nearly normal pH-activity curve, and increased utilization of 2-deoxyglucose-6-phosphate (76% of the rate with glucose-6-phosphate).	Glucose-6-Phosphate	171-190	glucose-6-phosphate dehydrogenase	Homo sapiens	4-8
6526380-2	1984	Glucose 6-phosphate formed during the initial 0.5 h of reaction was heavily labelled in C-1 and thus is consistent with the prediction of the liver (L)-type pentose phosphate pathway (theoretically C-1/C-6 = 0.5).	Glucose-6-Phosphate	0-19	complement C6	Rattus norvegicus	198-205
6094657-8	1984	The cytochemical reaction utilizing the Gomori lead capture method indicated that G6Pase in anterior pituitary cells may function as a phosphohydrolase for converting glucose-6-phosphate to glucose.	Glucose-6-Phosphate	167-186	glucose-6-phosphatase, catalytic	Mus musculus	82-88
6742859-11	1984	Furthermore, low concentrations (0.1 mM) of glucose 6-phosphate (G6P) or ATP4- specifically solubilize hexokinase.	Glucose-6-Phosphate	44-63	hexokinase-2	Oryctolagus cuniculus	103-113
23195383-9	1984	Moreover, the dissociation constants for phosphoenolpyruvate (plus or minus MgCl(2)) and malate in the presence of glucose-6-phosphate were calculated at pH 7.0, 7.5, and 7.9 from the protection afforded by these compounds against chemical modification of phosphoenolpyruvate carboxylase by phenylglyoxal.	Glucose-6-Phosphate	115-134	MLO-like protein 4	Zea mays	256-287
6388570-6	1984	Hexokinase, which is present in both islet and purified B-cell homogenates, is indeed inhibited by glucose 6-phosphate (Ki 0.13 mM) and glucose 1,6-bisphosphate (Ki approx.	Glucose-6-Phosphate	99-118	hexokinase 1	Homo sapiens	0-10
6736041-0	1984	Effects of glucose 6-phosphate and hemin on activation of heme-regulated eIF-2 alpha kinase in gel-filtered reticulocyte lysates.	Glucose-6-Phosphate	11-30	eukaryotic translation initiation factor 2A	Homo sapiens	73-84
6742859-11	1984	Furthermore, low concentrations (0.1 mM) of glucose 6-phosphate (G6P) or ATP4- specifically solubilize hexokinase.	Glucose-6-Phosphate	65-68	hexokinase-2	Oryctolagus cuniculus	103-113
6742859-17	1984	This model involves the existence of two kinds of interactions between HK and mitochondria; a very specific one with the hexokinase-binding protein of the outer mitochondrial membrane, which is suppressed by glucose 6-phosphate, and a less specific, cation-mediated one.	Glucose-6-Phosphate	208-227	hexokinase-2	Oryctolagus cuniculus	71-73
6742859-17	1984	This model involves the existence of two kinds of interactions between HK and mitochondria; a very specific one with the hexokinase-binding protein of the outer mitochondrial membrane, which is suppressed by glucose 6-phosphate, and a less specific, cation-mediated one.	Glucose-6-Phosphate	208-227	hexokinase-2	Oryctolagus cuniculus	121-131
6320929-6	1984	The mean Kis of lead for glucose-6-phosphate and nicotinamide adenine dinucleotide phosphate (NADP) for G6PD were 1.5 microM and 2.1 microM, respectively, which is within the range of intraerythrocytic lead concentrations found in clinical lead poisoning.	Glucose-6-Phosphate	25-44	glucose-6-phosphate dehydrogenase	Homo sapiens	104-108
6736560-2	1984	In a subsequent incubation in the presence of pyruvate kinase, phosphoenolpyruvate, radioactive glucose and hexokinase, ATP and ADP are estimated together by coupling their recycling to the formation of glucose 6-phosphate.	Glucose-6-Phosphate	203-222	hexokinase 1	Homo sapiens	108-118
6424657-2	1984	The binding to glycogen phosphorylase b of glucose 6-phosphate and inorganic phosphate (respectively allosteric inhibitor and substrate/activator of the enzyme) were studied in the crystal at 0.3 nm (3A) resolution.	Glucose-6-Phosphate	43-62	glycogen phosphorylase B	Homo sapiens	15-39
6413822-4	1983	Staining with glucose-6-phosphate as a substrate resulted in the detection of both G6PD and 6PGD.	Glucose-6-Phosphate	14-33	Zwischenferment	Drosophila melanogaster	83-87
6311976-1	1983	Repeated washing of a brain mitochondrial fraction results in a progressive decrease in the proportion of mitochondrially bound hexokinase that can be solubilized during a subsequent incubation with glucose-6-phosphate (glucose-6-P).	Glucose-6-Phosphate	199-218	hexokinase 1	Homo sapiens	128-138
6311976-1	1983	Repeated washing of a brain mitochondrial fraction results in a progressive decrease in the proportion of mitochondrially bound hexokinase that can be solubilized during a subsequent incubation with glucose-6-phosphate (glucose-6-P).	Glucose-6-Phosphate	220-231	hexokinase 1	Homo sapiens	128-138
6311976-5	1983	Both lysophospholipids and acidic phospholipids were active in enhancing solubilization of hexokinase by glucose-6-P.	Glucose-6-Phosphate	105-116	hexokinase 1	Homo sapiens	91-101
6603359-1	1983	The flux ratio for hexokinase type II from rat muscle, i.e. the rate of conversion of glucose 6-phosphate molecules into ATP molecules divided by the simultaneous rate of conversion of glucose 6-phosphate molecules into glucose molecules, increases with the MgATP concentration but is independent of the glucose concentration.	Glucose-6-Phosphate	86-105	hexokinase 2	Rattus norvegicus	19-37
6603359-1	1983	The flux ratio for hexokinase type II from rat muscle, i.e. the rate of conversion of glucose 6-phosphate molecules into ATP molecules divided by the simultaneous rate of conversion of glucose 6-phosphate molecules into glucose molecules, increases with the MgATP concentration but is independent of the glucose concentration.	Glucose-6-Phosphate	185-204	hexokinase 2	Rattus norvegicus	19-37
6222931-4	1983	Experimental conditions that increased the rate of nonenzymatic protein glycosylation (higher monosaccharide concentration, glucose-6-phosphate) were associated with correspondingly greater degrees of resistance to degradation by plasmin.	Glucose-6-Phosphate	124-143	plasminogen	Homo sapiens	230-237
6886661-5	1983	In all species except the goby, two groups of isozymes were distinguished, corresponding to the mammalian G6PD (specific for glucose-6-phosphate (G6P) and NADP+) and H6PD (capable of utilizing galactose-6-phosphate and in certain cases other monosaccharide phosphates in addition to G6P).	Glucose-6-Phosphate	125-144	glucose-6-phosphate dehydrogenase	Homo sapiens	106-110
6886661-5	1983	In all species except the goby, two groups of isozymes were distinguished, corresponding to the mammalian G6PD (specific for glucose-6-phosphate (G6P) and NADP+) and H6PD (capable of utilizing galactose-6-phosphate and in certain cases other monosaccharide phosphates in addition to G6P).	Glucose-6-Phosphate	146-149	glucose-6-phosphate dehydrogenase	Homo sapiens	106-110
6319214-12	1984	However, the fall-rise sequence of glucose-6-phosphate concentration constitutes the first direct evidence in vivo for simultaneous inhibition at the level of glucose-6-phosphatase.	Glucose-6-Phosphate	35-54	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	159-180
6440265-9	1984	The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH.	Glucose-6-Phosphate	152-171	interleukin 6	Homo sapiens	65-68
6440265-9	1984	The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH.	Glucose-6-Phosphate	152-171	glucose-6-phosphate dehydrogenase	Homo sapiens	43-47
6440265-9	1984	The NADPH-cytochrome c (P450) reductase of G6PD-deficient HL and HSF homogenates becomes lower than that of controls when endogenous G6PD and exogenous glucose 6-phosphate (G6P) and NADP+ are used as a hydrogen donor system in place of NADPH.	Glucose-6-Phosphate	43-46	interleukin 6	Homo sapiens	65-68
6422927-2	1983	The three forms of G6PD are characterized by different apparent Km values for glucose-6-phosphate but similar apparent Km values for NAPD+.	Glucose-6-Phosphate	78-97	Zwischenferment	Drosophila melanogaster	19-23
6628659-1	1983	Thrombin inhibits the rate of glucose-6-phosphate and 6-phosphogluconate oxidation.	Glucose-6-Phosphate	30-49	coagulation factor II, thrombin	Homo sapiens	0-8
6309951-5	1983	Of the different substrates employed, glucose-6-phosphate and mannose-6-phosphate were the only two with which G6Pase reaction product was seen in the neuronal ER and organelles related morphologically to the ER.	Glucose-6-Phosphate	38-57	glucose-6-phosphatase, catalytic	Mus musculus	111-117
6860590-5	1983	Since the intracellular concentrations of glucose-6-phosphate, 6-phosphogluconate and NADP are below their Kms for G6PD and 6PGD, the kinetic data suggest that increased concentrations of 2,3-diphosphoglycerate in pyruvate kinase deficient red cells are sufficiently high to suppress pentose phosphate shunt activity.	Glucose-6-Phosphate	42-61	phosphogluconate dehydrogenase	Homo sapiens	124-128
6302165-1	1983	Glucose-6-phosphatase (G6Pase) activity, with glucose-6-phosphate and mannose-6-phosphate as substrates, was examined by cytochemistry in capillary and arteriole endothelial cells of the mouse brain.	Glucose-6-Phosphate	46-65	glucose-6-phosphatase, catalytic	Mus musculus	0-21
6302165-1	1983	Glucose-6-phosphatase (G6Pase) activity, with glucose-6-phosphate and mannose-6-phosphate as substrates, was examined by cytochemistry in capillary and arteriole endothelial cells of the mouse brain.	Glucose-6-Phosphate	46-65	glucose-6-phosphatase, catalytic	Mus musculus	23-29
6131106-3	1983	Our previous work showed that the heat-stable factor is composed of at least two components, HSF-1 and HSF-2, and identified HSF-2 as D-glucose-6-phosphate.	Glucose-6-Phosphate	134-155	heat shock transcription factor 2	Rattus norvegicus	125-130
6413822-4	1983	Staining with glucose-6-phosphate as a substrate resulted in the detection of both G6PD and 6PGD.	Glucose-6-Phosphate	14-33	Phosphogluconate dehydrogenase	Drosophila melanogaster	92-96
6288113-1	1982	Formation of sorbitol 6-phosphate by bovine and human lens aldose reductase and sorbitol dehydrogenase by the reduction of glucose 6-phosphate and fructose 6-phosphate, respectively, has been demonstrated.	Glucose-6-Phosphate	123-142	aldo-keto reductase family 1 member B	Homo sapiens	59-75
6219667-12	1982	Although the patterns were of the classical type, there was more randomization of (14)C into C-2 and C-1 in the glucose 6-phosphate isolated at the end of the incubation than in the glucose which was continuously produced.	Glucose-6-Phosphate	112-131	complement C2	Rattus norvegicus	93-96
7142217-14	1982	This special relation was not observed for added yeast hexokinase in forming glucose 6-phosphate.	Glucose-6-Phosphate	77-96	hexokinase	Saccharomyces cerevisiae S288C	55-65
6816651-4	1982	When the ability of insulin to stimulate the conversion of the glucose-6-phosphate dependent to the glucose-6-phosphate independent form of glycogen synthase was measured, all cell lines responded, albeit to differing degrees.	Glucose-6-Phosphate	63-82	insulin	Homo sapiens	20-27
6816651-4	1982	When the ability of insulin to stimulate the conversion of the glucose-6-phosphate dependent to the glucose-6-phosphate independent form of glycogen synthase was measured, all cell lines responded, albeit to differing degrees.	Glucose-6-Phosphate	100-119	insulin	Homo sapiens	20-27
6286288-2	1982	A detailed kinetic analysis of G-6-Pase activity has been performed to distinguish between effects on the microsomal carrier for glucose-6-phosphate and those on the enzyme itself.	Glucose-6-Phosphate	129-148	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	31-39
6288113-1	1982	Formation of sorbitol 6-phosphate by bovine and human lens aldose reductase and sorbitol dehydrogenase by the reduction of glucose 6-phosphate and fructose 6-phosphate, respectively, has been demonstrated.	Glucose-6-Phosphate	123-142	sorbitol dehydrogenase	Homo sapiens	80-102
6954519-4	1982	The inability of glucosamine and mannose to promote a transport curb in the PGI strain must be ascribed to the fact that the 6-esters of these aldohexoses are converted by their own specific deaminase and isomerase to fructose 6-phosphate, which initiates the pyruvate-tricarboxylate energy-yielding pathway but cannot be converted to glucose 6-phosphate in the mutant.	Glucose-6-Phosphate	335-354	glucose-6-phosphate isomerase	Cricetulus griseus	76-79
7113101-3	1982	The increase in the glucose-6-phosphate level in the heart dependent on changes in the activity of glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	20-39	glucose-6-phosphate dehydrogenase	Rattus norvegicus	99-132
6953434-1	1982	A monoclonal antibody of the IgG class was prepared against rat liver glucose-6-phosphate dehydrogenase (G6PD; D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC 1.1.1.49) by the hybridoma technique.	Glucose-6-Phosphate	111-132	glucose-6-phosphate dehydrogenase	Rattus norvegicus	70-103
6953434-1	1982	A monoclonal antibody of the IgG class was prepared against rat liver glucose-6-phosphate dehydrogenase (G6PD; D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC 1.1.1.49) by the hybridoma technique.	Glucose-6-Phosphate	111-132	glucose-6-phosphate dehydrogenase	Rattus norvegicus	105-109
7053766-2	1982	In order to assess somatic cell mosaicism in various tissues, we have made use of the different rate of utilization of 2-deoxyglucose-6-phosphate, an analog of glucose-6-phosphate, by normal glucose-6-phosphate dehydrogenase and by the Mediterranean variant: the results demonstrate that essential thrombocythemia is a clonal disease involving the erythrocytic, granulocytic, and megakaryocytic series, without affecting monocytes, T lymphocytes, and non-T lymphocytes.	Glucose-6-Phosphate	126-145	glucose-6-phosphate dehydrogenase	Homo sapiens	191-224
6133035-2	1982	In 1978, we suggested that a basic defect of GSD 1b exists in the glucose-6-phosphate (G6P) transport system (Narisawa et al., 1978; Igarashi et al., 1979).	Glucose-6-Phosphate	66-85	solute carrier family 37 member 4	Homo sapiens	45-51
6133035-2	1982	In 1978, we suggested that a basic defect of GSD 1b exists in the glucose-6-phosphate (G6P) transport system (Narisawa et al., 1978; Igarashi et al., 1979).	Glucose-6-Phosphate	87-90	solute carrier family 37 member 4	Homo sapiens	45-51
7305385-0	1981	Kinetic evidence that the high-affinity glucose 6-phosphate site on hexokinase I is the active site.	Glucose-6-Phosphate	40-59	hexokinase 1	Homo sapiens	68-80
7047296-1	1982	The enzyme inositol-1-phosphate synthase (I-1-P synthase), product of the INO1 locus, catalyzes the synthesis of inositol-1-phosphate from the substrate glucose-6-phosphate.	Glucose-6-Phosphate	153-172	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	74-78
6270145-5	1981	2-Deoxyglucose reversed the effect of glucose, glycerol, and lactate on ALA synthase induction suggesting that the glucose effect is mediated by free glucose or glucose 6-phosphate or a nonglycolytic metabolite of glucose 6-phosphate.	Glucose-6-Phosphate	161-180	5'-aminolevulinate synthase 1	Gallus gallus	72-84
6270145-5	1981	2-Deoxyglucose reversed the effect of glucose, glycerol, and lactate on ALA synthase induction suggesting that the glucose effect is mediated by free glucose or glucose 6-phosphate or a nonglycolytic metabolite of glucose 6-phosphate.	Glucose-6-Phosphate	214-233	5'-aminolevulinate synthase 1	Gallus gallus	72-84
6279450-6	1982	The glucose moieties of glucose 1-phosphate, glucose 6-phosphate and glucose 1,6-bisphosphate were degraded and showed that epididymal fat pad enzymes relocate 14C from [2-14C]glucose into C-1, C-2, and C-3 of each hexose-phosphate.	Glucose-6-Phosphate	45-64	complement C2	Rattus norvegicus	194-197
6279450-6	1982	The glucose moieties of glucose 1-phosphate, glucose 6-phosphate and glucose 1,6-bisphosphate were degraded and showed that epididymal fat pad enzymes relocate 14C from [2-14C]glucose into C-1, C-2, and C-3 of each hexose-phosphate.	Glucose-6-Phosphate	45-64	complement C3	Rattus norvegicus	203-206
7036592-10	1981	With the strain used (K. oxytoca) the MIC of 128 mg/l was lowered by contact with G-6-P during 60 or 120 min to 16 or 8 mg/l respectively (Fig.	Glucose-6-Phosphate	82-87	microphthalmia Japan	Mus musculus	38-41
7246739-9	1981	The high activity of hexokinase in the segments of the distal tubule points to the role of glucose as metabolic fuel, glycogen precursor, and other glucose-6-phosphate-using pathways in these structures.	Glucose-6-Phosphate	148-167	hexokinase-2	Oryctolagus cuniculus	21-31
6275855-17	1981	It is suggested that the role of glucose 6-phosphate in muscle is either to produce glucose from glucose 6-phosphate derived from glycogen or to provide the enzymic basis for a substrate ("futile") cycle between glucose and glucose 6-phosphatase in muscle to improve the sensitivity of the mechanism that regulates the rate of glucose phosphorylation.	Glucose-6-Phosphate	33-52	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	224-245
24233801-1	1981	myo-Inositol-1-phosphate synthase (EC 5.5.1.4) from rat testes, an NAD(+)-containing enzyme, which convertsD-glucose 6-phosphate to 1L-myo-inositol 1-phosphate, could be immobilized together with its cofactor and bovine serum albumin by crosslinking with glutaraldehyde at pH 4.5.	Glucose-6-Phosphate	108-128	albumin	Rattus norvegicus	220-233
7259990-1	1981	Two new glucose-6-phosphate dehydrogenase (G6PD, D-glucose 6-phosphate: NADP oxido reductase, E.C.	Glucose-6-Phosphate	49-70	glucose-6-phosphate dehydrogenase	Homo sapiens	8-41
7259990-1	1981	Two new glucose-6-phosphate dehydrogenase (G6PD, D-glucose 6-phosphate: NADP oxido reductase, E.C.	Glucose-6-Phosphate	49-70	glucose-6-phosphate dehydrogenase	Homo sapiens	43-47
6115414-1	1981	Glucose-6-phosphate isomerase (EC 5.3.1.9) is a dimeric enzyme of molecular mass 132000 which catalyses the interconversion of D-glucose-6-phosphate and D-fructose-6-phosphate.	Glucose-6-Phosphate	127-148	glucose-6-phosphate isomerase	Sus scrofa	0-29
7195012-12	1981	It is concluded that the glucose increase is confined to the intracellular pool and is an effect of hexokinase inhibition by accumulated glucose 6-phosphate.	Glucose-6-Phosphate	137-156	hexokinase 1	Homo sapiens	100-110
6974156-2	1981	Orthophosphate (Pi) at low concentrations, is able to activate the glucose 6-phosphate, glucose-1,6-diphosphate or 2,3-diphosphoglycerate-inhibited hexokinase (E.C.	Glucose-6-Phosphate	67-86	hexokinase-2	Oryctolagus cuniculus	148-158
6165636-6	1981	Optimal aromatase activity was achieved by incubating cell-free sonicates at 37 degrees C in the presence of O2 in 20 mM phosphate buffer (pH 7.4) containing 5 mM dithiothreitol, 20 mM MgCl2, 0.5 mM NADP+, 20 mM glucose 6-phosphate and 2 U/ml glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	212-231	cytochrome P450, family 19, subfamily a, polypeptide 1	Rattus norvegicus	8-17
6786379-5	1981	The mutant forms of G6PD restoring the viability of flies without 6-phosphogluconate dehydrogenase show drastically increased Km values for NADP and/or glucose-6-phosphate.	Glucose-6-Phosphate	152-171	Zwischenferment	Drosophila melanogaster	20-24
6786379-5	1981	The mutant forms of G6PD restoring the viability of flies without 6-phosphogluconate dehydrogenase show drastically increased Km values for NADP and/or glucose-6-phosphate.	Glucose-6-Phosphate	152-171	Phosphogluconate dehydrogenase	Drosophila melanogaster	66-98
6996676-1	1980	Glucose, and certain sugars that can readily be converted to glucose 6-phosphate, bring about an activation of adipose-tissue lipoprotein lipase when epididymal fat-bodies from starved rats are incubated in the presence of cycloheximide.	Glucose-6-Phosphate	61-80	lipoprotein lipase	Rattus norvegicus	126-144
6460465-3	1981	The procedure is based on the conversion of glucose-6-phosphate to 1,3-diphosphoglycerate (1,3-DPG) which is catalyzed by the sequential action of the GPI, PFK, AL and GAPD.	Glucose-6-Phosphate	44-63	glucose-6-phosphate isomerase	Homo sapiens	151-154
6460465-3	1981	The procedure is based on the conversion of glucose-6-phosphate to 1,3-diphosphoglycerate (1,3-DPG) which is catalyzed by the sequential action of the GPI, PFK, AL and GAPD.	Glucose-6-Phosphate	44-63	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	168-172
7426668-5	1980	Although it has been reported that the only effective nucleotide as the phosphoryl donor for hexokinase from various origin in ATP, and that ADP, a reaction product, inhibits the enzyme, hexokinase D from the rainbow-trout liver was found to be able to form glucose 6-phosphate (Glc-6-P) from glucose and various nucleotides such as ATP, ADP, CTP, GTP, UTP and UDP.	Glucose-6-Phosphate	258-277	hexokinase 1	Homo sapiens	187-197
7426668-5	1980	Although it has been reported that the only effective nucleotide as the phosphoryl donor for hexokinase from various origin in ATP, and that ADP, a reaction product, inhibits the enzyme, hexokinase D from the rainbow-trout liver was found to be able to form glucose 6-phosphate (Glc-6-P) from glucose and various nucleotides such as ATP, ADP, CTP, GTP, UTP and UDP.	Glucose-6-Phosphate	279-286	hexokinase 1	Homo sapiens	187-197
6249579-0	1980	Investigations on the possible involvement of phospholipids in the glucose-6-phosphate transport system of rat-liver microsomal glucose-6-phosphatase.	Glucose-6-Phosphate	67-86	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	128-149
7213758-11	1981	The use of Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ 1-oxidoreductase, EC 1.1.1.49), with NAD as cofactor, is recommended for measuring hexokinases in crude tissue preparations to avoid the variable further reduction of nucleotide caused by the action of 6-phosphogluconate dehydrogenase when NADP is used with yeast glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	72-93	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	37-70
7213758-11	1981	The use of Leuconostoc mesenteroides glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ 1-oxidoreductase, EC 1.1.1.49), with NAD as cofactor, is recommended for measuring hexokinases in crude tissue preparations to avoid the variable further reduction of nucleotide caused by the action of 6-phosphogluconate dehydrogenase when NADP is used with yeast glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	72-93	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	365-398
6253473-0	1980	Evidence for the participation of independent translocation for phosphate and glucose 6-phosphate in the microsomal glucose-6-phosphatase system.	Glucose-6-Phosphate	78-97	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	116-137
7408190-1	1980	This paper describes a method to determine transketolase activity in erythrocytes, with or without addition of thiamine-pyrophosphate, by quantitating the formation of glucose-6-phosphate forming during the incubation of hemolysed blood with ribose-5-phosphate.	Glucose-6-Phosphate	168-187	transketolase	Homo sapiens	43-56
7397199-1	1980	The activity of phosphoenolpyruvate carboxylase (orthophosphate:oxaloacetate carboxy-lyase (phosporylating) EC 4.1.1.31) purified from Bryophyllum fedtschenkoi has been measured in the presence of various concentrations of phosphoenolpyruvate, L-malate and glucose 6-phosphate.	Glucose-6-Phosphate	257-276	phosphoenolpyruvate carboxykinase 1	Homo sapiens	16-47
7372415-4	1980	However, hexokinase (HK) was found to be the rate-limiting step: the glucose-supported reduction rate was only 50% of that of G6P-supported activity.	Glucose-6-Phosphate	126-129	hexokinase 1	Homo sapiens	9-19
7372415-4	1980	However, hexokinase (HK) was found to be the rate-limiting step: the glucose-supported reduction rate was only 50% of that of G6P-supported activity.	Glucose-6-Phosphate	126-129	hexokinase 1	Homo sapiens	21-23
6252822-2	1980	It consists of two assays : in the first, the ATP formed by blood AK is coupled to Hx and G6PD, and in the second, the glucose-6-phosphate formed by blood Hx is coupled to G6PD.	Glucose-6-Phosphate	119-138	hexokinase 1	Homo sapiens	155-157
6252822-2	1980	It consists of two assays : in the first, the ATP formed by blood AK is coupled to Hx and G6PD, and in the second, the glucose-6-phosphate formed by blood Hx is coupled to G6PD.	Glucose-6-Phosphate	119-138	glucose-6-phosphate dehydrogenase	Homo sapiens	172-176
468829-1	1979	Kinetic studies of phosphoacetylglucosamine mutase (EC 2.7.5.2) for the following reactions: 1) Glc-1-P in equilibrium Glc-6-P and 2) GlcNAc-1-P in equilibrium GlcNAc-6-P have been conducted in the presence of Glc-1,6-P2 and GlcNAc-1,6-P2, respectively.	Glucose-6-Phosphate	119-126	phosphoglucomutase 3	Homo sapiens	19-50
6987674-5	1980	Addition of glucose 6-phosphate, whose intracellular concentration increases in response to insulin, also stimulates Ca2+ uptake, a unique property of this preparation.	Glucose-6-Phosphate	12-31	insulin	Homo sapiens	92-99
7440222-1	1980	The presumed "physiologic activity" of normal glucose 6-phosphate dehydrogenase (G6PD), i.e. activity assayed in the presence of physiologic concentrations of ATP, 2,3-diphosphoglycerate, glucose 6-phosphate, NADP and NADPH in the normal red cells, is comparable to shunt pathway activity of intact normal red cells.	Glucose-6-Phosphate	46-65	glucose-6-phosphate dehydrogenase	Homo sapiens	81-85
519850-2	1979	Glucose-6-phosphate dehydrogenase activity is corrected for the contributing activity of 6-phosphogluconate dehydrogenase (EC 1.1.1.44) by using a two-cuvet system in which the activity of the sample incubated with 6-phosphogluconic acid is subtracted from the activity produced in the presence of the combined substrates, glucose-6-phosphate and 6-phosphogluconic acid.	Glucose-6-Phosphate	323-342	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
468829-1	1979	Kinetic studies of phosphoacetylglucosamine mutase (EC 2.7.5.2) for the following reactions: 1) Glc-1-P in equilibrium Glc-6-P and 2) GlcNAc-1-P in equilibrium GlcNAc-6-P have been conducted in the presence of Glc-1,6-P2 and GlcNAc-1,6-P2, respectively.	Glucose-6-Phosphate	119-126	GLC1P	Homo sapiens	96-103
467432-15	1979	A direct study of the effect of glucose 6-phosphate on the conformational equilibrium of wheat germ hexokinase, gives support to this interpretation.	Glucose-6-Phosphate	32-51	hexokinase-6	Triticum aestivum	100-110
233578-0	1979	Magnetic resonance studies of the spatial arrangement of glucose-6-phosphate and chromium (III)-adenosine diphosphate at the catalytic site of hexokinase.	Glucose-6-Phosphate	57-76	hexokinase	Saccharomyces cerevisiae S288C	143-153
467432-1	1979	Effect of glucose 6-phosphate and temperature on the molecular transition of wheat-germ hexokinase LI.	Glucose-6-Phosphate	10-29	hexokinase-6	Triticum aestivum	88-98
467432-16	1979	If hexokinase is mixed at 4 degrees C with glucose 6-phosphate a slow increase in fluorescence of tryptophanyl residues is observed, which indicates that the "rhombus" conformation accumulates under these conditions.	Glucose-6-Phosphate	43-62	hexokinase-6	Triticum aestivum	3-13
467432-6	1979	The first case above is expected to apply to wheat germ hexokinase LI, X1 being the form that binds glucose preferentially, and X6 the one that binds glucose 6-phosphate.	Glucose-6-Phosphate	150-169	hexokinase-6	Triticum aestivum	56-66
382625-4	1979	A hypothesis is advanced, according to which the discrepancy in data on biochemical study of the patients in vivo and in vitro is due to absence of a specific permease in liver tissue, which transfers glucose-6-phosphate from cytosol onto the innesurface of membranes of cytoplasmic network, where glucose-6-phosphatase is located.	Glucose-6-Phosphate	201-220	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	298-319
467432-12	1979	When wheat germ hexokinase LI is pre-mixed 30 min at 30 degrees C with glucose 6-phosphate before the reaction starts, the burst does not disappear.	Glucose-6-Phosphate	71-90	hexokinase-6	Triticum aestivum	16-26
31177-1	1978	Pure glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate:NADP+ 1-oxidoreductase, EC 1.1.1.49) is transformed into "hyperanodic forms" when incubated at acidic pH and in the presence of NADP+ with excess of glucose-6-phosphate or with some "NADP+ modifying proteins" purified from the same cells.	Glucose-6-Phosphate	40-61	glucose-6-phosphate dehydrogenase	Homo sapiens	5-38
221037-2	1979	The capacity for the synthesis of glucose 6-phosphate from PPi and glucose as well as for glucose-6-P hydrolysis, catalyzed by rat liver microsomal glucose-6-phosphatase, increases rapidly from low prenatal levels to a maximum between the second and fifth day, then slowly decreases to reach adult levels.	Glucose-6-Phosphate	34-53	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	148-169
108019-1	1979	In immature human placentas, the activity of the I (glucose-6-phosphate-independent) form of glycogen synthase is significantly increased by insulin, glucose and by both compounds associated.	Glucose-6-Phosphate	52-71	insulin	Homo sapiens	141-148
422533-4	1979	This demethylation reaction had apparent Km values of 2.61 X 10(-5) M for NADP+, 4.93 X 10(-5) m for glucose 6-phosphate, and 2.14 X 10(-4) m for 2-deoxyglucose 6-phosphate, a synthetic substrate for glucose dehydrogenase.	Glucose-6-Phosphate	101-120	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	200-221
35102-0	1979	Anomerization of glucose 6-phosphate: catalysis by phosphoglucose isomerase.	Glucose-6-Phosphate	17-36	glucose-6-phosphate isomerase	Homo sapiens	51-75
488851-1	1979	Recent evidence has suggested a role for the polyol pathway in pathogenesis of cell damage in diabetes Glucose may be phosphorylated to glucose-6-phosphate via hexokinase and enter glycolysis or reduced to sorbitol via aldose reductase to enter the polyol pathway.	Glucose-6-Phosphate	136-155	hexokinase 1	Homo sapiens	160-170
214450-5	1978	Taken together with the immunological data in the companion paper, the findings indicate that the enzymes NADPH cyt c reductase and probably glucose-6-phosphate are indigenous components of Golgi membranes.	Glucose-6-Phosphate	141-160	cytochrome c, somatic	Homo sapiens	112-117
447625-3	1979	When incorporated into lipid vesicles, the protein confers the ability to bind brain hexokinase in a Glc-6-P-sensitive manner as is seen with the intact outer mitochondrial membrane.	Glucose-6-Phosphate	101-108	hexokinase 1	Homo sapiens	85-95
369601-0	1979	Yeast hexokinase in solution exhibits a large conformational change upon binding glucose or glucose 6-phosphate.	Glucose-6-Phosphate	92-111	hexokinase	Saccharomyces cerevisiae S288C	6-16
231460-5	1979	The enzyme shows a strong affinity for glucose-6-phosphate (Km = 2.5 mM, VM = 220 nmoles.min-1mg-1).	Glucose-6-Phosphate	39-58	CD59 molecule (CD59 blood group)	Homo sapiens	89-98
758095-2	1978	The best conditions for detection of hexokinase activity were developed using immobilization of glucose-6-phosphate dehydrogenas: in gel, utilization of riboflavin as a catalyst of polymerization and stabilization by glucose.	Glucose-6-Phosphate	96-115	hexokinase 1	Homo sapiens	37-47
23188-3	1977	The abnormal enzyme differs from the normal by decreased Michaelis constant for glucose-6-phosphate and nicotinamide adenine dinucleotide phosphate (NADP), by increased utilization of analogues of substrates--2-deoxy-glucose-6-phosphate and particularly deamino-NADP, by low thermal stability, by the character of pH-dependence, by the appearance of a single band of G6PD activity in polyacrylamide gel electrophoresis.	Glucose-6-Phosphate	80-99	glucose-6-phosphate dehydrogenase	Homo sapiens	367-371
200264-0	1977	Conversion of skeletal muscle glycogen synthase to multiple glucose 6-phosphate dependent forms by cyclic adenosine monophosphate dependent and independent protein kinases.	Glucose-6-Phosphate	60-79	glycogen synthase 1	Homo sapiens	14-47
631848-4	1978	GPI "Paris" was characterized by a slow electrophoretic migration and, above all, a drastically altered affinity for the substrates glucose-6-phosphate (decreased) and fructose-6-phosphate (increased).	Glucose-6-Phosphate	132-151	glucose-6-phosphate isomerase	Homo sapiens	0-3
631848-5	1978	GPI "Enfants malades" exhibited a slightly reduced electrophoretic mobility, an abnormal curve of the activity in function of pH, and an abnormal ratio of maximal velocity in the backward direction (fructose-6-phosphate leads to glucose-6-phosphate) to that in the forward direction (glucose-6-phosphate leads to fructose-6-phosphate).	Glucose-6-Phosphate	229-248	glucose-6-phosphate isomerase	Homo sapiens	0-3
631848-5	1978	GPI "Enfants malades" exhibited a slightly reduced electrophoretic mobility, an abnormal curve of the activity in function of pH, and an abnormal ratio of maximal velocity in the backward direction (fructose-6-phosphate leads to glucose-6-phosphate) to that in the forward direction (glucose-6-phosphate leads to fructose-6-phosphate).	Glucose-6-Phosphate	284-303	glucose-6-phosphate isomerase	Homo sapiens	0-3
203457-0	1978	Evidence for the involvement of a glucose-6-phosphate carrier in microsomal glucose-6-phosphatase activity.	Glucose-6-Phosphate	34-53	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	76-97
335048-21	1977	The rate of insulin release with glucose-6-phosphate was concentration dependent.10.	Glucose-6-Phosphate	33-52	insulin	Oryctolagus cuniculus	12-19
16345245-3	1977	The method is based on the reaction between glucose and adenosine 5"-triphosphate, catalyzed by hexokinase to form glucose-6-phosphate.	Glucose-6-Phosphate	115-134	hexokinase 1	Homo sapiens	96-106
889576-1	1977	Inhibition studies of glucokinase were carried out with the products of the reaction, glucose 6-phosphate and MgADP-, as well as with ADP3-, Mg2+ and ATP4-.	Glucose-6-Phosphate	86-105	glucokinase	Rattus norvegicus	22-33
10305-0	1976	Quantitative aspects of relationship between glucose 6-phosphate transport and hydrolysis for liver microsomal glucose-6-phosphatase system.	Glucose-6-Phosphate	45-64	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	111-132
16660007-4	1977	These organelles also contain the majority of the cellular 6-phosphogluconate dehydrogenase, transketolase, and transaldolase activities.The consequence of these enzyme distributions is that glucose 6-phosphate or 6-phosphogluconate produced in the cytosol must be transported into the proplastids where conversion to pyruvate occurs.	Glucose-6-Phosphate	191-210	transaldolase	Ricinus communis	112-125
142521-7	1977	The descending segment is a result of the inhibition of the phosphofructokinase by ATP and the strong inhibition of the hexokinase by glucose-6-phosphate.	Glucose-6-Phosphate	134-153	hexokinase 1	Homo sapiens	120-130
196677-4	1977	Solubilizations by ATP and glucose-6-phosphate differ in their sensitivity to temperature changes; they are relatively specific for glucokinase as compared to solubilization by detergent (Triton X 100).	Glucose-6-Phosphate	27-46	glucokinase	Homo sapiens	132-143
16386049-0	1976	The stereospecificity of the glucose-6-phosphate binding site of glycogen phosphorylase b.	Glucose-6-Phosphate	29-48	glycogen phosphorylase B	Homo sapiens	65-89
11834-0	1976	Glucose 6-phosphate-dependent binding of hexokinase to membranes of ascites tumor cells.	Glucose-6-Phosphate	0-19	hexokinase 1	Homo sapiens	41-51
1032950-2	1976	Incubation of submaxillary-gland slices with isoproterenol, a beta-adrenergic agonist, stimulated glucose removal by 41% and decreased tissue [glucose 6-phosphate] by 50%.	Glucose-6-Phosphate	143-162	amyloid beta precursor protein	Rattus norvegicus	60-66
949457-1	1976	The apparent Michaelis constant (Km) for glucose-6-phosphate of the enzyme glucose-6-phosphate dehydrogenase has been measured in extracts prepared from biopsies of normal human skin and from both affected and apparently normal skin of patients with lichen planus.	Glucose-6-Phosphate	41-60	glucose-6-phosphate dehydrogenase	Homo sapiens	75-108
1088480-5	1976	In the presence of epinephrine, the low concentration (50 microunits/ml) of insulin induces the decrease of the content of glucose-6-phosphate.	Glucose-6-Phosphate	123-142	insulin	Homo sapiens	76-83
792424-4	1976	It is postulated that after initiation of secretion, continued insulin release is under the control of phosphorylated intermediates of glucose metabolism, i.e. glucose-6-phosphate and phosphoenol pyruvate, operating via a membrane-bound protein kinase.	Glucose-6-Phosphate	160-179	insulin	Homo sapiens	63-70
1276080-4	1976	One variant (G6PD Hamm) had a low Km-value for glucose-6-phosphate, the other (G6PD Tarsus) exhibited an increased affinity for glucose-6-phosphate and a reduced affinity for NADP+.	Glucose-6-Phosphate	47-66	glucose-6-phosphate dehydrogenase	Homo sapiens	13-17
1276080-4	1976	One variant (G6PD Hamm) had a low Km-value for glucose-6-phosphate, the other (G6PD Tarsus) exhibited an increased affinity for glucose-6-phosphate and a reduced affinity for NADP+.	Glucose-6-Phosphate	128-147	glucose-6-phosphate dehydrogenase	Homo sapiens	13-17
2388-1	1976	The molar absorptivity of NADH at 340 nm has been determined by an indirect procedure in which high-purity glucose is phosphorylated by ATP in the presence of hexokinase, coupled to oxidation of the glucose-6-phosphate by NAD+ in the presence of glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	199-218	hexokinase 1	Homo sapiens	159-169
4439-4	1976	The pH of maximum activity is 8.5 and the ionic strength maximum is 0.1 to 0.5 M. Glucose-6-phosphate dehydrogenase is highly specific for NADP+ and glucose 6-phosphate.	Glucose-6-Phosphate	149-168	glucose-6-phosphate dehydrogenase	Sus scrofa	82-115
7238-0	1976	Dehydrogenation of the phosphonate analogue of glucose 6-phosphate by glucose 6-phosphate dehydrogenase.	Glucose-6-Phosphate	47-66	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	70-103
1037202-1	1976	To determine the activity of cholesterol 7alpha-hydroxylase, different fractions from rat liver homogenates are incubated with glucose-6-phosphate, glucose-6-phosphate dehydrogenase and NADP as well as with cholesterol-4-14C.	Glucose-6-Phosphate	127-146	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	29-59
4472062-0	1974	Dimerization of brain hexokinase induced by its regulator glucose 6-phosphate.	Glucose-6-Phosphate	58-77	hexokinase 1	Homo sapiens	22-32
235736-0	1975	On the involvement of a glucose 6-phosphate transport system in the function of microsomal glucose 6-phosphatase.	Glucose-6-Phosphate	24-43	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	91-112
235736-2	1975	Glucose 6-phosphatase is postulated to be resultant of the coupling of two components of the microsomal membrane: 1) a glucose 6-phosphate - specific transport system which functions to shuttle the sugar phosphate from the cytoplasm to the lumen of the endoplasmic reticulum; and 2) a catalytic component, glucose-6-P phosphohydrolase, bound to the luminal surface of the membrane.	Glucose-6-Phosphate	119-138	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
1054832-1	1975	Mutants of Chinese hamster ovary cells deficient in glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP 1-oxidoreducatse, EC 1.1.1.49) activity were isolated after mutagenesis with ethyl methane sulfonate.	Glucose-6-Phosphate	87-108	glucose-6-phosphate 1-dehydrogenase	Cricetulus griseus	52-85
1227919-1	1975	Experimental investigations have shown estradiol-dipropionate and insulin to induce an elevated activity of glucose-6-phosphate- and 6-phospho-gluconate-dehydrogenase in the uterus and the liver.	Glucose-6-Phosphate	108-127	insulin	Homo sapiens	66-73
1140197-6	1975	The latter ATP analogue, when bound to Sepharose through its terminal amino group, could be dephosphorylated to the corresponding ADP analogue with soluble hexokinase yielding glucose 6-phosphate in an enzymic "solidphase" fashion.	Glucose-6-Phosphate	176-195	hexokinase 1	Homo sapiens	156-166
1057170-7	1975	Moreover, the human isozymes of hlucose-6-phosphate dehydrogenase (EC 1.1.1.49; D-glucose 6-phosphate:NADP 1-oxidoreductase) and phosphoglycerate kinase (EC 2.7.2.3;ATP:3-phospho-D-glycerate 1-phosphotransferase), whose genes have been linked with the HPRT gene to the long are of the human X chromosome, were also absent.	Glucose-6-Phosphate	80-101	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	252-256
4839039-0	1974	Mutarotase (aldose-1-epimerase) catalyzed anomerization of glucose-6-phosphate.	Glucose-6-Phosphate	59-78	galactose mutarotase	Homo sapiens	12-30
16742819-2	1973	The concerted actions of glucose phosphate isomerase, phosphofructokinase, aldolase and triose phosphate isomerase catalysed the loss of (3)H from [5-(3)H,U-(14)C]glucose 6-phosphate.	Glucose-6-Phosphate	163-182	triosephosphate isomerase 1	Homo sapiens	88-114
4753200-0	1973	The stereospecificity of D-glucose-6-phosphate: 1L-myo-inositol-1-phosphate cycloaldolase on the hydrogen atoms at C-6.	Glucose-6-Phosphate	25-46	complement C6	Homo sapiens	115-118
4578852-0	1973	The effect of substitution at C-2 of D-glucose 6-phosphate on the rate of dehydrogenation by glucose 6-phosphate dehydrogenase (from yeast and from rat liver).	Glucose-6-Phosphate	37-58	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	93-126
4578852-14	1973	Lineweaver-Burk plots for the d-glucose 6-phosphate derivatives with yeast glucose 6-phosphate dehydrogenase were biphasic.	Glucose-6-Phosphate	30-51	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	75-108
4118294-1	1972	The catabolite repression caused by glucose and glucose-6-phosphate has been studied for both beta-galactosidase and thiogalactoside transacetylase, the products of the operator proximal and distal cistrons of the lac operon, respectively.	Glucose-6-Phosphate	48-67	galactosidase beta 1	Homo sapiens	94-112
4570343-0	1972	The effect of substitution at C-2 of D-glucose 6-phosphate on the rate of dehydrogenation by yeast glucose 6-phosphate dehydrogenase.	Glucose-6-Phosphate	37-58	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	99-132
5157725-6	1971	A beta-adrenoceptor-mediated increase in force of contraction (phenylephrine and isoprenaline; rat heart) was associated with a reduction in the amounts of ATP and CP and an increase in the amount of G-6-P.6.	Glucose-6-Phosphate	200-205	amyloid beta precursor protein	Rattus norvegicus	0-6
4399403-6	1971	The substrate, glucose 6-phosphate, protects the glucose 6-phosphatase activity of microsomal preparations against peroxidation or detergents.	Glucose-6-Phosphate	15-34	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	49-70
6069283-2	1967	It is proposed that the hexokinase is a host enzyme bound to the surface of the meningopneumonitis cell and that glucose-6-phosphate is the first substrate in the conversion of hexose to pentose to be attacked by enzymes synthesized by the meningopneumonitis agent.	Glucose-6-Phosphate	113-132	hexokinase 1	Homo sapiens	24-34
5432802-0	1970	Effect of glucose 6-phosphate on the nucleotide site of glycogen phosphorylase b.	Glucose-6-Phosphate	10-29	glycogen phosphorylase B	Homo sapiens	56-80
4395001-7	1970	Glucose 6-phosphatase activity was present in amounts comparable with the total glucose-phosphorylating activity, with K(m) 1mm for glucose 6-phosphate.	Glucose-6-Phosphate	132-151	glucose-6-phosphatase, catalytic	Mus musculus	0-21
4974869-0	1969	Presence of two or more glucose-6-phosphate pools in voluntary skeletal muscle and their sensitivity to insulin.	Glucose-6-Phosphate	24-43	insulin	Homo sapiens	104-111
6049880-0	1967	Inhibition of brain hexokinase by glucose 6-phosphate.	Glucose-6-Phosphate	34-53	hexokinase 1	Homo sapiens	20-30
13211596-0	1954	The non-competitive inhibition of brain hexokinase by glucose-6-phosphate and related compounds.	Glucose-6-Phosphate	54-73	hexokinase 1	Homo sapiens	40-50
6025550-3	1967	Injection of insulin caused an increase in both the total activity of glycogen synthetase and the activity that was independent of glucose-6-phosphate.	Glucose-6-Phosphate	131-150	insulin	Oryctolagus cuniculus	13-20
13907310-0	1962	The effect of ACTH upon adrenal glucose-6-phosphate metabolizing enzymes.	Glucose-6-Phosphate	32-51	proopiomelanocortin	Homo sapiens	14-18
14005573-0	1961	[Glucose-6-phosphate dehydrogenase and its correlations with the similar substrates of glucose-6-phosphate.	Glucose-6-Phosphate	87-106	glucose-6-phosphate dehydrogenase	Homo sapiens	1-34
13684982-0	1961	Equilibrium constants of phosphoryl transfer from C-1 to C-6 of alpha-D-glucose 1-phosphate and from glucose 6-phosphate to water.	Glucose-6-Phosphate	101-120	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	50-60
16749180-3	1966	Short-term experiments indicate a slight inhibition of glucose uptake for a brief period, due either to ATP accumulation in the mitochondria or to glucose 6-phosphate-mediated inhibition of hexokinase.	Glucose-6-Phosphate	147-166	hexokinase 1	Homo sapiens	190-200
5941005-0	1966	Insulin responsive and nonresponsive pools of glucose 6-phosphate in diaphragmatic muscle.	Glucose-6-Phosphate	46-65	insulin	Homo sapiens	0-7
14340056-7	1965	The appearance of microsomal glucose 6-phosphatase activity around birth has an effect on glycolysis owing to competition for glucose 6-phosphate.	Glucose-6-Phosphate	126-145	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	29-50
33964207-1	2021	SLC37A4 encodes an endoplasmic reticulum (ER)-localized multitransmembrane protein required for transporting glucose-6-phosphate (Glc-6P) into the ER.	Glucose-6-Phosphate	130-136	solute carrier family 37 member 4	Homo sapiens	0-7
13125597-0	1954	Transketolase-catalyzed utilization of fructose 6-phosphate and its significance in a glucose 6-phosphate oxidation cycle.	Glucose-6-Phosphate	86-105	transketolase	Homo sapiens	0-13
33986801-4	2021	Here, we show that the phosphoglucomutase (PGM) family member PGM5 promotes conversion of glucose-1-phosphate (G1P) into glucose-6-phosphate (G6P) and inhibits breast cancer cell proliferation and migration through regulating aerobic glycolysis.	Glucose-6-Phosphate	142-145	phosphoglucomutase 5	Homo sapiens	62-66
33292639-5	2020	MondoA is the principal regulator of glucose-induced transcription, and its activity is triggered by the glycolytic intermediate, glucose 6-phosphate (G6P).	Glucose-6-Phosphate	151-154	MLX interacting protein	Homo sapiens	0-6
33137488-1	2021	OBJECTIVE: Glucose production into the blood requires the expression of glucose-6 phosphatase (G6Pase), a key enzyme that allows glucose-6 phosphate (G6P) hydrolysis into free glucose and inorganic phosphate.	Glucose-6-Phosphate	95-98	glucose-6-phosphatase, catalytic	Mus musculus	72-93
32474930-1	2021	Glycogen storage disease type Ia (GSD-Ia) is an inherited metabolic disease caused by a deficiency in glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC) which plays a critical role in blood glucose homeostasis by catalyzing the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of glycogenolysis and gluconeogenesis.	Glucose-6-Phosphate	131-134	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	147-151
32111666-1	2020	Former studies on Arabidopsis glucose-6-phosphate/phosphate translocator isoforms GPT1 and GPT2 reported viability of gpt2 mutants, however an essential function for GPT1, manifesting as a variety of gpt1 defects in the heterozygous state during fertilization/seed set.	Glucose-6-Phosphate	30-49	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	82-86
32102842-5	2020	Here, we report the crystal structures of cyanobacterial (Synechococcus elongatus) PRK in complex with adenosine diphosphate and glucose-6-phosphate, and of the Arabidopsis thaliana GAPDH/CP12/PRK complex, providing detailed information regarding the active site of PRK, and the key elements essential for PRK-CP12 interaction.	Glucose-6-Phosphate	129-148	phosphoribulokinase	Arabidopsis thaliana	83-86
31845160-4	2020	In this study, mice cortical neurons preconditioned with sublethal exposure to oxygen glucose deprivation (OGD) exhibited ATM/glucose-6-phosphate dehydrogenase pathway activation.	Glucose-6-Phosphate	126-145	ataxia telangiectasia mutated	Mus musculus	122-125
32459324-1	2020	Activation of phosphoenolpyruvate carboxylase (PEPC) enzymes by glucose 6-phosphate (G6P) and other phospho-sugars is of major physiological relevance.	Glucose-6-Phosphate	85-88	MLO-like protein 4	Zea mays	14-45
32459324-1	2020	Activation of phosphoenolpyruvate carboxylase (PEPC) enzymes by glucose 6-phosphate (G6P) and other phospho-sugars is of major physiological relevance.	Glucose-6-Phosphate	85-88	MLO-like protein 4	Zea mays	47-51
32459324-6	2020	Inhibition was also observed in the wild-type enzyme at concentrations of G6P higher than those producing activation, and probably arises from G6P binding to the active site in competition with PEP.	Glucose-6-Phosphate	74-77	phosphoenolpyruvate carboxylase 2	Zea mays	194-197
32459324-9	2020	Furthermore, our findings suggest a central role of the G6P-allosteric site in the overall kinetics of these enzymes even in the absence of G6P or other phospho-sugars, because of its involvement in activation by free-PEP.	Glucose-6-Phosphate	56-59	phosphoenolpyruvate carboxylase 2	Zea mays	218-221
32111666-1	2020	Former studies on Arabidopsis glucose-6-phosphate/phosphate translocator isoforms GPT1 and GPT2 reported viability of gpt2 mutants, however an essential function for GPT1, manifesting as a variety of gpt1 defects in the heterozygous state during fertilization/seed set.	Glucose-6-Phosphate	30-49	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	118-122
32111666-6	2020	Reconstitution in yeast proteoliposomes revealed that GPT1 preferentially exchanges glucose-6-phosphate for ribulose-5-phosphate.	Glucose-6-Phosphate	84-103	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	54-58
32059860-7	2020	Feed restriction increased milk glucose-6-phosphate and isocitrate (+38% and +39%, respectively) and decreased milk BHB, glucose, glutamate, uric acid and free amino group concentrations (-20%, -57%, -65%, -42%, and -14%, respectively), compared with pre- restriction.	Glucose-6-Phosphate	32-51	Weaning weight-maternal milk	Bos taurus	27-31
31670839-8	2020	The contribution of pentose phosphate pathway (PPP) to CYP3A reduction was investigated by chemical interfering and silencing of glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	129-148	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	55-60
32306986-2	2020	Glucose 6-phosphate (G6P) availability has been shown to modulate 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1), an ER-bound enzyme catalyzing the local conversion of inactive cortisone into active cortisol.	Glucose-6-Phosphate	21-24	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	110-120
32059860-10	2020	All studied milk metabolites were significantly correlated with energy balance (Spearman correlation = 0.48, 0.63, -0.31, -0.45, and 0.61 for BHB, glucose, glucose-6-phosphate, isocitrate, and glutamate, respectively).	Glucose-6-Phosphate	156-175	Weaning weight-maternal milk	Bos taurus	12-16
31651049-4	2020	Consequently, CG amount, NADH, D-glucose-6-phosphate (G6P), phosphate buffer and the pH, and ionic strength of solution had important effects on the residual activity of CG-G6PD.	Glucose-6-Phosphate	31-52	glucose-6-phosphate dehydrogenase	Homo sapiens	173-177
32195170-2	2020	Among all glycolytic enzymes, hexokinase (HK), a rate-limiting enzyme at the first step of glycolysis to catalyze cellular glucose into glucose-6-phosphate, is herein emphasized.	Glucose-6-Phosphate	136-155	hexokinase 1	Homo sapiens	30-40
32195170-2	2020	Among all glycolytic enzymes, hexokinase (HK), a rate-limiting enzyme at the first step of glycolysis to catalyze cellular glucose into glucose-6-phosphate, is herein emphasized.	Glucose-6-Phosphate	136-155	hexokinase 1	Homo sapiens	42-44
31651049-5	2020	Moreover, CG amount, the pH, and G6P played important roles in changing CG labeling location on G6PD.	Glucose-6-Phosphate	33-36	glucose-6-phosphate dehydrogenase	Homo sapiens	96-100
32180557-7	2020	RESULTS: The results showed that loss of miR-122 promoted glutaminolysis but suppressed gluconeogenesis in mouse livers as evident from the buildup of 13C- and/or 15N-Glu and decrease in glucose-6-phosphate (G6P) levels, respectively, in KO livers.	Glucose-6-Phosphate	208-211	microRNA 122	Mus musculus	41-48
31974165-4	2020	The G6P lowering by metformin was mimicked by a complex 1 inhibitor (rotenone) and an uncoupler (dinitrophenol) and by overexpression of mGPDH, which lowers glycerol 3-phosphate and G6P and also mimics the G6pc repression by metformin.	Glucose-6-Phosphate	4-7	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	137-142
31974165-4	2020	The G6P lowering by metformin was mimicked by a complex 1 inhibitor (rotenone) and an uncoupler (dinitrophenol) and by overexpression of mGPDH, which lowers glycerol 3-phosphate and G6P and also mimics the G6pc repression by metformin.	Glucose-6-Phosphate	4-7	glucose-6-phosphatase, catalytic	Mus musculus	206-210
31651049-4	2020	Consequently, CG amount, NADH, D-glucose-6-phosphate (G6P), phosphate buffer and the pH, and ionic strength of solution had important effects on the residual activity of CG-G6PD.	Glucose-6-Phosphate	54-57	glucose-6-phosphate dehydrogenase	Homo sapiens	173-177
31735334-7	2020	Intriguingly, hepatic levels of glucose-6-phosphate and glycogen which are accumulated in the G6Pase-alpha-deficient livers were significantly lower in HCC than those in HCA.	Glucose-6-Phosphate	32-51	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	94-106
31466140-4	2020	The PFK mutations (Pfk1 S724D and Pfk2 S718D) result in less glycerol production and more accumulation of G6P, which is a gateway metabolite toward the oxidative PP pathway.	Glucose-6-Phosphate	106-109	6-phosphofructokinase subunit alpha	Saccharomyces cerevisiae S288C	19-23
31466140-4	2020	The PFK mutations (Pfk1 S724D and Pfk2 S718D) result in less glycerol production and more accumulation of G6P, which is a gateway metabolite toward the oxidative PP pathway.	Glucose-6-Phosphate	106-109	6-phosphofructokinase subunit beta	Saccharomyces cerevisiae S288C	34-38
31876373-3	2020	Arabidopsis thaliana ("arabidopsis") has three genes encoding myo-inositol phosphate synthases (IPS1-3), the enzymes that catalyse conversion of glucose-6-phosphate to InsP, the first step in InsP6 biosynthesis.	Glucose-6-Phosphate	145-164	induced by phosphate starvation1	Arabidopsis thaliana	96-102
31993438-0	2019	Glucose-6-Phosphate Upregulates Txnip Expression by Interacting With MondoA.	Glucose-6-Phosphate	0-19	thioredoxin interacting protein	Homo sapiens	32-37
31993438-0	2019	Glucose-6-Phosphate Upregulates Txnip Expression by Interacting With MondoA.	Glucose-6-Phosphate	0-19	MLX interacting protein	Homo sapiens	69-75
31993438-2	2019	Here, we show that G6P can be sensed by the transcription factor MondoA/Mlx to modulate Txnip expression.	Glucose-6-Phosphate	19-22	MLX interacting protein	Homo sapiens	65-71
31993438-2	2019	Here, we show that G6P can be sensed by the transcription factor MondoA/Mlx to modulate Txnip expression.	Glucose-6-Phosphate	19-22	MAX dimerization protein MLX	Homo sapiens	72-75
31993438-2	2019	Here, we show that G6P can be sensed by the transcription factor MondoA/Mlx to modulate Txnip expression.	Glucose-6-Phosphate	19-22	thioredoxin interacting protein	Homo sapiens	88-93
31993438-3	2019	Endogenous knockdown and EMSA (gel migration assay) analyses both confirmed that G6P is the metabolic intermediate that activates the heterocomplex MondoA/Mlx to elicit the expression of Txnip.	Glucose-6-Phosphate	81-84	MLX interacting protein	Homo sapiens	148-154
31993438-3	2019	Endogenous knockdown and EMSA (gel migration assay) analyses both confirmed that G6P is the metabolic intermediate that activates the heterocomplex MondoA/Mlx to elicit the expression of Txnip.	Glucose-6-Phosphate	81-84	MAX dimerization protein MLX	Homo sapiens	155-158
31993438-3	2019	Endogenous knockdown and EMSA (gel migration assay) analyses both confirmed that G6P is the metabolic intermediate that activates the heterocomplex MondoA/Mlx to elicit the expression of Txnip.	Glucose-6-Phosphate	81-84	thioredoxin interacting protein	Homo sapiens	187-192
31993438-4	2019	Additionally, the three-dimensional structure of MondoA is modeled, and the binding mode of G6P to MondoA is also predicted by in silico molecular docking and binding free energy calculation.	Glucose-6-Phosphate	92-95	MLX interacting protein	Homo sapiens	49-55
31993438-4	2019	Additionally, the three-dimensional structure of MondoA is modeled, and the binding mode of G6P to MondoA is also predicted by in silico molecular docking and binding free energy calculation.	Glucose-6-Phosphate	92-95	MLX interacting protein	Homo sapiens	99-105
31993438-5	2019	Finally, free energy decomposition and mutational analyses suggest that certain residues in MondoA, GKL139-141 in particular, mediate its binding with G6P to activate MondoA, which signals the upregulation of the expression of Txnip.	Glucose-6-Phosphate	151-154	MLX interacting protein	Homo sapiens	92-98
31993438-5	2019	Finally, free energy decomposition and mutational analyses suggest that certain residues in MondoA, GKL139-141 in particular, mediate its binding with G6P to activate MondoA, which signals the upregulation of the expression of Txnip.	Glucose-6-Phosphate	151-154	MLX interacting protein	Homo sapiens	167-173
31993438-5	2019	Finally, free energy decomposition and mutational analyses suggest that certain residues in MondoA, GKL139-141 in particular, mediate its binding with G6P to activate MondoA, which signals the upregulation of the expression of Txnip.	Glucose-6-Phosphate	151-154	thioredoxin interacting protein	Homo sapiens	227-232
31698999-0	2020	Glucose 6-Phosphate Accumulates via Phosphoglucose Isomerase Inhibition in Heart Muscle.	Glucose-6-Phosphate	0-19	glucose-6-phosphate isomerase	Homo sapiens	36-60
31698999-5	2020	Metabolic control analysis revealed that glucose 6-phosphate concentration is dependent on phosphoglucose isomerase activity.	Glucose-6-Phosphate	41-60	glucose-6-phosphate isomerase	Homo sapiens	91-115
31374327-3	2019	Protein expression levels of Itgb2 and glucose-6-phosphate dehydrogenase (G6pd) proteins were assessed by flow cytometry and the glucose-6-phosphate (G6P) substrate method, respectively.	Glucose-6-Phosphate	39-58	glucose-6-phosphate dehydrogenase	Homo sapiens	74-78
31102537-6	2019	Hepatic G6P accumulation induces sterol 12alpha-hydroxylase (Cyp8b1) expression, which is mediated by the major glucose-sensitive transcription factor, carbohydrate response element-binding protein (ChREBP).	Glucose-6-Phosphate	8-11	cytochrome P450, family 8, subfamily b, polypeptide 1	Mus musculus	33-59
31102537-6	2019	Hepatic G6P accumulation induces sterol 12alpha-hydroxylase (Cyp8b1) expression, which is mediated by the major glucose-sensitive transcription factor, carbohydrate response element-binding protein (ChREBP).	Glucose-6-Phosphate	8-11	cytochrome P450, family 8, subfamily b, polypeptide 1	Mus musculus	61-67
31102537-6	2019	Hepatic G6P accumulation induces sterol 12alpha-hydroxylase (Cyp8b1) expression, which is mediated by the major glucose-sensitive transcription factor, carbohydrate response element-binding protein (ChREBP).	Glucose-6-Phosphate	8-11	MLX interacting protein-like	Mus musculus	152-197
31102537-6	2019	Hepatic G6P accumulation induces sterol 12alpha-hydroxylase (Cyp8b1) expression, which is mediated by the major glucose-sensitive transcription factor, carbohydrate response element-binding protein (ChREBP).	Glucose-6-Phosphate	8-11	MLX interacting protein-like	Mus musculus	199-205
31614497-4	2019	The components of the glucose-6-phosphatase system (i.e., glucose-6-phosphate transporter and glucose-6-phosphatase itself) were analyzed in homogenates or microsomal fractions prepared from the small intestine mucosae and liver of rats, guinea pigs, and humans.	Glucose-6-Phosphate	58-77	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	22-43
31614497-6	2019	The results showed that the glucose-6-phosphatase system is poorly represented in the small intestine of rats; on the other hand, significant expressions of glucose-6-phosphate transporter and of the glucose-6-phosphatase were found in the small intestine of guinea pigs and homo sapiens.	Glucose-6-Phosphate	157-176	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	28-49
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Glucose-6-Phosphate	186-205	trehalose-6-phosphate synthase	Medicago truncatula	95-125
31921241-2	2019	The trehalose pathway is conserved among different organisms and is composed of three enzymes: trehalose-6-phosphate synthase (TPS), which converts uridine diphosphate (UDP)-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P), trehalose-6-phosphatase (TPP), which dephosphorylates T6P to produce trehalose, and trehalase (TRE), responsible for trehalose catabolism.	Glucose-6-Phosphate	186-205	trehalose-6-phosphate synthase	Medicago truncatula	127-130
31754032-4	2019	Inositol tetrakisphosphate 1-kinase 1 (ITPK1)-found in Asgard archaea, social amoeba, plants, and animals-phosphorylates I(3)P1 originating from glucose-6-phosphate, and I(1)P1 generated from sphingolipids, to enable synthesis of IP6 We also found using PAGE mass assay that metabolic blockage by phosphate starvation surprisingly increased IP6 levels in a ITPK1-dependent manner, establishing a route to IP6 controlled by cellular metabolic status, that is not detectable by traditional [3H]-inositol labeling.	Glucose-6-Phosphate	145-164	inositol-tetrakisphosphate 1-kinase	Homo sapiens	0-37
31754032-4	2019	Inositol tetrakisphosphate 1-kinase 1 (ITPK1)-found in Asgard archaea, social amoeba, plants, and animals-phosphorylates I(3)P1 originating from glucose-6-phosphate, and I(1)P1 generated from sphingolipids, to enable synthesis of IP6 We also found using PAGE mass assay that metabolic blockage by phosphate starvation surprisingly increased IP6 levels in a ITPK1-dependent manner, establishing a route to IP6 controlled by cellular metabolic status, that is not detectable by traditional [3H]-inositol labeling.	Glucose-6-Phosphate	145-164	inositol-tetrakisphosphate 1-kinase	Homo sapiens	39-44
31374327-3	2019	Protein expression levels of Itgb2 and glucose-6-phosphate dehydrogenase (G6pd) proteins were assessed by flow cytometry and the glucose-6-phosphate (G6P) substrate method, respectively.	Glucose-6-Phosphate	150-153	integrin subunit beta 2	Homo sapiens	29-34
31374327-3	2019	Protein expression levels of Itgb2 and glucose-6-phosphate dehydrogenase (G6pd) proteins were assessed by flow cytometry and the glucose-6-phosphate (G6P) substrate method, respectively.	Glucose-6-Phosphate	150-153	glucose-6-phosphate dehydrogenase	Homo sapiens	74-78
31574935-4	2019	By application of electric pulses in the millisecond range, permanent lethal pores are formed in the cell membrane of Escherichia coli and Saccharomyces cerevisiae, facilitating the release of the cellular contents; here demonstrated by the measurement of glucose-6-phosphate and the activity of the enzyme glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	256-275	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	307-340
31394311-6	2019	Glucose-6-phosphate isomerase (GPI), a rate-limiting enzyme converting glucose-6-phosphate to fructose-6-phosphate, was found to be significantly decreased in asthenozoospermia by Western blotting and ELISA on an extended sample size.	Glucose-6-Phosphate	71-90	glucose-6-phosphate isomerase	Homo sapiens	0-29
31394311-6	2019	Glucose-6-phosphate isomerase (GPI), a rate-limiting enzyme converting glucose-6-phosphate to fructose-6-phosphate, was found to be significantly decreased in asthenozoospermia by Western blotting and ELISA on an extended sample size.	Glucose-6-Phosphate	71-90	glucose-6-phosphate isomerase	Homo sapiens	31-34
30820758-0	2019	Development of Voltammetric Glucose-6-phosphate Biosensors Based on the Immobilization of Glucose-6-phosphate Dehydrogenase on Polypyrrole- and Chitosan-Coated Fe3O4 Nanoparticles/Polypyrrole Nanocomposite Films.	Glucose-6-Phosphate	28-47	glucose-6-phosphate dehydrogenase	Homo sapiens	90-123
31295070-2	2019	Regulation of HK includes feedback inhibition by its product glucose-6-phosphate (G6P) and mitochondria binding.	Glucose-6-Phosphate	61-80	hexokinase 1	Homo sapiens	14-16
31295070-2	2019	Regulation of HK includes feedback inhibition by its product glucose-6-phosphate (G6P) and mitochondria binding.	Glucose-6-Phosphate	82-85	hexokinase 1	Homo sapiens	14-16
31295070-7	2019	This is the first simple assay that evaluates feedback inhibition of HK by its product G6P and provides a unique technique for future research evaluating the regulation of glucose phosphorylation under various physiological conditions.NEW & NOTEWORTHY Traditionally, hexokinase activity has been analyzed spectrophotometrically in which the product formation of glucose-6-phosphate (G6P) is analyzed by an indirect reaction coupled to NADPH formation during conversion of G6P to 6-P gluconolactone.	Glucose-6-Phosphate	366-385	hexokinase 1	Homo sapiens	69-71
31295070-7	2019	This is the first simple assay that evaluates feedback inhibition of HK by its product G6P and provides a unique technique for future research evaluating the regulation of glucose phosphorylation under various physiological conditions.NEW & NOTEWORTHY Traditionally, hexokinase activity has been analyzed spectrophotometrically in which the product formation of glucose-6-phosphate (G6P) is analyzed by an indirect reaction coupled to NADPH formation during conversion of G6P to 6-P gluconolactone.	Glucose-6-Phosphate	87-90	hexokinase 1	Homo sapiens	69-71
31295070-7	2019	This is the first simple assay that evaluates feedback inhibition of HK by its product G6P and provides a unique technique for future research evaluating the regulation of glucose phosphorylation under various physiological conditions.NEW & NOTEWORTHY Traditionally, hexokinase activity has been analyzed spectrophotometrically in which the product formation of glucose-6-phosphate (G6P) is analyzed by an indirect reaction coupled to NADPH formation during conversion of G6P to 6-P gluconolactone.	Glucose-6-Phosphate	387-390	hexokinase 1	Homo sapiens	69-71
30923324-7	2019	Finally, we demonstrated that DDB2 knockdown increases glucose uptake and intracellular levels of glucose-6-phosphate in HepG2 cells.	Glucose-6-Phosphate	98-117	damage specific DNA binding protein 2	Homo sapiens	30-34
31372018-3	2019	Glucokinase is predominantly expressed in pancreatic beta cells and catalyzes the phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	112-131	glucokinase	Homo sapiens	0-11
31275507-3	2019	In this work, we report the first utilization of a Markov-state model (MSM) to describe the surface diffusion of a reaction intermediate, glucose 6-phosphate, on an artificially modified cascade where hexokinase and glucose-6-phosphate dehydrogenase are covalently conjugated by a cationic oligopeptide bridge.	Glucose-6-Phosphate	138-157	hexokinase 1	Homo sapiens	201-211
31275507-3	2019	In this work, we report the first utilization of a Markov-state model (MSM) to describe the surface diffusion of a reaction intermediate, glucose 6-phosphate, on an artificially modified cascade where hexokinase and glucose-6-phosphate dehydrogenase are covalently conjugated by a cationic oligopeptide bridge.	Glucose-6-Phosphate	138-157	glucose-6-phosphate dehydrogenase	Homo sapiens	216-249
31212816-3	2019	Hexokinase 2 (HK2) converts glucose to glucose-6-phosphate, the first committed step in glucose metabolism.	Glucose-6-Phosphate	39-58	hexokinase 2	Homo sapiens	0-12
31212816-3	2019	Hexokinase 2 (HK2) converts glucose to glucose-6-phosphate, the first committed step in glucose metabolism.	Glucose-6-Phosphate	39-58	hexokinase 2	Homo sapiens	14-17
31354221-6	2019	Results: It was determined that HKII could not only transform glucose into glucose-6-phosphate, but also transfer the phosphate group of ATP onto PDHA1.	Glucose-6-Phosphate	75-94	hexokinase 2	Homo sapiens	32-36
32259054-10	2019	Other sugar phosphates, including glucose-1-phosphate, glucose-6-phosphate, fructose-6-phosphate, and fructose-1,6-bisphosphate, also potentiated PTH-induced adenylyl cyclase activation.	Glucose-6-Phosphate	55-74	parathyroid hormone	Rattus norvegicus	146-149
30930048-1	2019	Glucose-6-phosphate dehydrogenase (G6PDH) is the key enzyme supplying reducing power (NADPH) to the cells, by oxidation of glucose-6-phosphate (G6P), and in the process providing a precursor of ribose-5-phosphate.	Glucose-6-Phosphate	123-142	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
30930048-1	2019	Glucose-6-phosphate dehydrogenase (G6PDH) is the key enzyme supplying reducing power (NADPH) to the cells, by oxidation of glucose-6-phosphate (G6P), and in the process providing a precursor of ribose-5-phosphate.	Glucose-6-Phosphate	123-142	glucose-6-phosphate dehydrogenase	Homo sapiens	35-40
30930048-1	2019	Glucose-6-phosphate dehydrogenase (G6PDH) is the key enzyme supplying reducing power (NADPH) to the cells, by oxidation of glucose-6-phosphate (G6P), and in the process providing a precursor of ribose-5-phosphate.	Glucose-6-Phosphate	35-38	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
31133865-2	2019	Glucose-6-phosphate isomerase (GPI, EC 5.3.1.9) is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate, the second reaction step of glycolysis.	Glucose-6-Phosphate	115-134	glucose-6-phosphate isomerase	Homo sapiens	0-29
31133865-2	2019	Glucose-6-phosphate isomerase (GPI, EC 5.3.1.9) is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate, the second reaction step of glycolysis.	Glucose-6-Phosphate	115-134	glucose-6-phosphate isomerase	Homo sapiens	31-34
30886114-6	2019	We found evidence that carbon is reimported as glucose-6-phosphate, forming a cytosolic bypass around the block of stromal triose phosphate isomerase.	Glucose-6-Phosphate	47-66	triosephosphate isomerase	Arabidopsis thaliana	123-149
30462889-5	2019	RESULTS: CaMK4 inhibition significantly decreased the levels of glycolytic intermediates such as glucose-6-phosphate, fructose-6-phosphate, fructose-1,6-diphosphate, pyruvate, and lactate (P < 0.05), whereas it did not affect the levels of the pentose phosphate pathway intermediates such as 6-phospho-d-gluconate, ribulose-5-phosphate, ribose-5-phosphate, and phosphoribosyl pyrophosphate.	Glucose-6-Phosphate	97-116	calcium/calmodulin dependent protein kinase IV	Homo sapiens	9-14
30983961-3	2019	GK catalyzes the phosphorylation of glucose to glucose-6-phosphate (G-6P), and its activity and subcellular localization are regulated by GKRP.	Glucose-6-Phosphate	47-66	glucokinase	Homo sapiens	0-2
30983961-3	2019	GK catalyzes the phosphorylation of glucose to glucose-6-phosphate (G-6P), and its activity and subcellular localization are regulated by GKRP.	Glucose-6-Phosphate	47-66	glucokinase regulator	Homo sapiens	138-142
30983961-3	2019	GK catalyzes the phosphorylation of glucose to glucose-6-phosphate (G-6P), and its activity and subcellular localization are regulated by GKRP.	Glucose-6-Phosphate	68-72	glucokinase	Homo sapiens	0-2
30983961-3	2019	GK catalyzes the phosphorylation of glucose to glucose-6-phosphate (G-6P), and its activity and subcellular localization are regulated by GKRP.	Glucose-6-Phosphate	68-72	glucokinase regulator	Homo sapiens	138-142
30949058-4	2019	Once inside, glucose is phosphorylated to glucose-6-phosphate by GCK in a reaction that is dependent on glucose throughout the physiological range of concentrations, is irreversible, and not product inhibited.	Glucose-6-Phosphate	42-61	glucokinase	Homo sapiens	65-68
31016042-1	2019	Background: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage.	Glucose-6-Phosphate	62-81	glucose-6-phosphate dehydrogenase	Homo sapiens	12-45
31016042-1	2019	Background: Glucose-6-phosphate dehydrogenase (G6PD) converts glucose-6-phosphate into 6-phosphogluconate in the pentose phosphate pathway and protects red blood cells (RBCs) from oxidative damage.	Glucose-6-Phosphate	62-81	glucose-6-phosphate dehydrogenase	Homo sapiens	47-51
30604625-9	2019	Activation of IMPA1 in response to increased glucose 6-phosphate (G6P) is known to play a critical role in inositol synthesis and recycling.	Glucose-6-Phosphate	45-64	inositol monophosphatase 1	Rattus norvegicus	14-19
30604625-9	2019	Activation of IMPA1 in response to increased glucose 6-phosphate (G6P) is known to play a critical role in inositol synthesis and recycling.	Glucose-6-Phosphate	66-69	inositol monophosphatase 1	Rattus norvegicus	14-19
30717828-5	2019	Mitochondria-bound hexokinase transfers a phosphate from mtATP to cytoplasmic glucose to generate glucose-6-phosphate (G6P), which is an established MondoA activator.	Glucose-6-Phosphate	98-117	hexokinase 1	Homo sapiens	19-29
30650008-8	2019	TTP overexpression decreased HK2 expression and suppressed the glycolytic capacity of cancer cells, measured as glucose uptake and production of glucose-6-phosphate, pyruvate, and lactate.	Glucose-6-Phosphate	145-164	ZFP36 ring finger protein	Homo sapiens	0-3
30717828-5	2019	Mitochondria-bound hexokinase transfers a phosphate from mtATP to cytoplasmic glucose to generate glucose-6-phosphate (G6P), which is an established MondoA activator.	Glucose-6-Phosphate	98-117	MLX interacting protein	Homo sapiens	149-155
30717828-5	2019	Mitochondria-bound hexokinase transfers a phosphate from mtATP to cytoplasmic glucose to generate glucose-6-phosphate (G6P), which is an established MondoA activator.	Glucose-6-Phosphate	119-122	hexokinase 1	Homo sapiens	19-29
30717828-5	2019	Mitochondria-bound hexokinase transfers a phosphate from mtATP to cytoplasmic glucose to generate glucose-6-phosphate (G6P), which is an established MondoA activator.	Glucose-6-Phosphate	119-122	MLX interacting protein	Homo sapiens	149-155
30958662-9	2019	However, CXCL14 inhibited glucose-6-phosphate generation and ATP production in mouse islets.	Glucose-6-Phosphate	26-45	chemokine (C-X-C motif) ligand 14	Mus musculus	9-15
30626647-3	2019	Using a combination of enzymological, cell-culture, and in vivo approaches, we demonstrate that G6PT and G6PC3 collaborate to destroy 1,5-anhydroglucitol-6-phosphate (1,5AG6P), a close structural analog of glucose-6-phosphate and an inhibitor of low-K M hexokinases, which catalyze the first step in glycolysis in most tissues.	Glucose-6-Phosphate	206-225	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	96-100
30626647-3	2019	Using a combination of enzymological, cell-culture, and in vivo approaches, we demonstrate that G6PT and G6PC3 collaborate to destroy 1,5-anhydroglucitol-6-phosphate (1,5AG6P), a close structural analog of glucose-6-phosphate and an inhibitor of low-K M hexokinases, which catalyze the first step in glycolysis in most tissues.	Glucose-6-Phosphate	206-225	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	105-110
30696020-4	2019	In this study, both the conversion of glucose to glucose-6-phosphate, catalyzed by hexokinase, and the conversion of adenosine-triphosphate to adenosine di-phosphate and mono-phosphate, catalyzed by apyrase, were monitored by BSI.	Glucose-6-Phosphate	49-68	hexokinase 1	Homo sapiens	83-93
29941676-5	2018	In human somatic cells, loss of TP53 thus triggers activation of DHEAS transport proteins and steroid sulfatase, which converts circulating DHEAS into intracellular DHEA, and hexokinase which increases glucose-6-phosphate substrate concentration.	Glucose-6-Phosphate	202-221	tumor protein p53	Homo sapiens	32-36
30256948-1	2019	Glucose-6-phosphatase alpha (G6Pase) deficiency, also known as von Gierke"s Disease or Glycogen storage disease type Ia (GSD Ia), is characterized by decreased ability of the liver to convert glucose-6-phosphate to glucose leading to glycogen accumulation and hepatosteatosis.	Glucose-6-Phosphate	192-211	glucose-6-phosphatase, catalytic	Mus musculus	29-35
30586356-4	2018	GPT1 transports glucose-6-phosphate (Glc6P) into plastids for starch and/or fatty acid biosynthesis depending on the plant species.	Glucose-6-Phosphate	37-42	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	0-4
30586356-4	2018	GPT1 transports glucose-6-phosphate (Glc6P) into plastids for starch and/or fatty acid biosynthesis depending on the plant species.	Glucose-6-Phosphate	37-42	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	26-35
30586356-9	2018	High-level expression of GPT1 at late stages of pollen development drives Glc6P from cytosol into plastids, where Glc6P is used for fatty acid biosynthesis, an important step of lipid body biogenesis.	Glucose-6-Phosphate	74-79	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	25-29
30586356-9	2018	High-level expression of GPT1 at late stages of pollen development drives Glc6P from cytosol into plastids, where Glc6P is used for fatty acid biosynthesis, an important step of lipid body biogenesis.	Glucose-6-Phosphate	114-119	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	25-29
29941676-5	2018	In human somatic cells, loss of TP53 thus triggers activation of DHEAS transport proteins and steroid sulfatase, which converts circulating DHEAS into intracellular DHEA, and hexokinase which increases glucose-6-phosphate substrate concentration.	Glucose-6-Phosphate	202-221	sulfotransferase family 2A member 1	Homo sapiens	65-70
29941676-5	2018	In human somatic cells, loss of TP53 thus triggers activation of DHEAS transport proteins and steroid sulfatase, which converts circulating DHEAS into intracellular DHEA, and hexokinase which increases glucose-6-phosphate substrate concentration.	Glucose-6-Phosphate	202-221	hexokinase 1	Homo sapiens	175-185
30335765-2	2018	Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), participates in both the breakdown and synthesis of glycogen.	Glucose-6-Phosphate	143-162	phosphoglucomutase 1	Homo sapiens	0-20
29663270-1	2018	Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the ubiquitously expressed glucose-6-phosphate (G6P) transporter (G6PT or SLC37A4).	Glucose-6-Phosphate	98-117	solute carrier family 37 (glucose-6-phosphate transporter), member 4	Mus musculus	137-141
29663270-1	2018	Glycogen storage disease type Ib (GSD-Ib) is caused by a deficiency in the ubiquitously expressed glucose-6-phosphate (G6P) transporter (G6PT or SLC37A4).	Glucose-6-Phosphate	98-117	solute carrier family 37 (glucose-6-phosphate transporter), member 4	Mus musculus	145-152
29671257-6	2018	However, inactivation of mitoHK-II by glucose-depletion or glucose-6-phosphate inhibited the GSK3beta-mediated mPTP opening.	Glucose-6-Phosphate	59-78	glycogen synthase kinase 3 beta	Homo sapiens	93-101
30464597-1	2018	Background: Glucose-6-phosphate isomerase (GPI) is a glycolytic-related enzyme that inter-converts glucose-6-phosphate and fructose-6-phosphate in the cytoplasm.	Glucose-6-Phosphate	99-118	glucose-6-phosphate isomerase	Homo sapiens	12-41
30464597-1	2018	Background: Glucose-6-phosphate isomerase (GPI) is a glycolytic-related enzyme that inter-converts glucose-6-phosphate and fructose-6-phosphate in the cytoplasm.	Glucose-6-Phosphate	99-118	glucose-6-phosphate isomerase	Homo sapiens	43-46
30335765-2	2018	Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), participates in both the breakdown and synthesis of glycogen.	Glucose-6-Phosphate	143-162	phosphoglucomutase 1	Homo sapiens	22-26
30335765-2	2018	Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), participates in both the breakdown and synthesis of glycogen.	Glucose-6-Phosphate	164-169	phosphoglucomutase 1	Homo sapiens	0-20
30335765-2	2018	Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the reversible conversion between glucose 1-phosphate (G-1-P) and glucose 6-phosphate (G-6-P), participates in both the breakdown and synthesis of glycogen.	Glucose-6-Phosphate	164-169	phosphoglucomutase 1	Homo sapiens	22-26
30279540-7	2018	Importantly, specific removal of PPi in fugu5, and thus in AVP1pro:IPP1 transgenic lines, restored the Glc1P and the Glc6P;Fru6P levels, increased the UDP-Glc level ~2.0-fold, and subsequently increased sucrose synthesis.	Glucose-6-Phosphate	117-122	protein phosphatase 1 regulatory inhibitor subunit 1A	Homo sapiens	67-71
30122451-1	2018	Human phosphoglucomutase 1 (PGM1) plays a central role in cellular glucose homeostasis, catalyzing the conversion of glucose 1-phosphate and glucose 6-phosphate.	Glucose-6-Phosphate	141-160	phosphoglucomutase 1	Homo sapiens	6-26
30122451-1	2018	Human phosphoglucomutase 1 (PGM1) plays a central role in cellular glucose homeostasis, catalyzing the conversion of glucose 1-phosphate and glucose 6-phosphate.	Glucose-6-Phosphate	141-160	phosphoglucomutase 1	Homo sapiens	28-32
29885360-1	2018	Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis.	Glucose-6-Phosphate	98-117	glucokinase	Homo sapiens	0-11
30183740-4	2018	Insulin resistance in obese participants was associated with impaired insulin signaling, and reduced levels of glucose-6-phosphate and TCA-cycle intermediates.	Glucose-6-Phosphate	111-130	insulin	Homo sapiens	0-7
29885360-1	2018	Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis.	Glucose-6-Phosphate	98-117	glucokinase	Homo sapiens	13-15
29580928-2	2018	Glucose-6-phosphate dehydrogenase (G6PD) is one of two key enzymes involved in the lipid accumulation in this fungi, which catalyzes the oxidative dehydrogenation of glucose-6-phosphate to 6-phosphoglucono-delta-lactone with the reduction of NADP+ to NADPH.	Glucose-6-Phosphate	166-185	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	0-33
30174791-5	2018	Glucose-6-phosphate (G6P) and ribose-5-phosphate (R5P) concentrations in PTX-1 cells were higher than those in USPC-1 cells.	Glucose-6-Phosphate	0-19	paired like homeodomain 1	Homo sapiens	73-78
30174791-5	2018	Glucose-6-phosphate (G6P) and ribose-5-phosphate (R5P) concentrations in PTX-1 cells were higher than those in USPC-1 cells.	Glucose-6-Phosphate	21-24	paired like homeodomain 1	Homo sapiens	73-78
29858906-1	2018	Background The phosphoglucomutase 1 (PGM1) enzyme plays a central role in glucose homeostasis by catalyzing the inter-conversion of glucose 1-phosphate and glucose 6-phosphate.	Glucose-6-Phosphate	156-175	phosphoglucomutase 1	Homo sapiens	15-35
29858906-1	2018	Background The phosphoglucomutase 1 (PGM1) enzyme plays a central role in glucose homeostasis by catalyzing the inter-conversion of glucose 1-phosphate and glucose 6-phosphate.	Glucose-6-Phosphate	156-175	phosphoglucomutase 1	Homo sapiens	37-41
29608987-3	2018	Further investigation revealed that shikonin-induced decreases of glucose-6-phosphate and pyruvate and downregulation of HK II and PKM2 were significantly prevented when RIP1 or RIP3 was pharmacologically inhibited or genetically knocked down with SiRNA.	Glucose-6-Phosphate	66-85	receptor interacting serine/threonine kinase 1	Homo sapiens	170-174
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Glucose-6-Phosphate	140-159	ADP dependent glucokinase	Homo sapiens	53-78
29784881-2	2018	In contrast to canonical hexokinases, which use ATP, ADP-dependent glucokinase (ADPGK) catalyzes noncanonical phosphorylation of glucose to glucose 6-phosphate using ADP as a phosphate donor.	Glucose-6-Phosphate	140-159	ADP dependent glucokinase	Homo sapiens	80-85
29784585-5	2018	Additionally, we show that silencing Gys2 expression reduces hepatic steatosis in a mouse model of GSD type Ia, where we hypothesize that the reduction of glycogen also reduces the production of excess glucose-6-phosphate and its subsequent diversion to lipid synthesis.	Glucose-6-Phosphate	202-221	glycogen synthase 2	Mus musculus	37-41
29719821-4	2018	SLC37A1 and SLC37A2 are Pi-linked glucose-6-phosphate (G6P) antiporters, catalyzing both homologous (Pi/Pi) and heterologous (G6P/Pi) exchanges, whereas SLC37A3 transport properties remain to be clarified.	Glucose-6-Phosphate	34-53	solute carrier family 37 member 1	Homo sapiens	0-7
29119535-11	2018	The impact of the mt-HK inhibition by glucose-6-phosphate (G6P) was the same in synaptosomes from both areas.	Glucose-6-Phosphate	38-57	hexokinase 1	Homo sapiens	21-23
29119535-11	2018	The impact of the mt-HK inhibition by glucose-6-phosphate (G6P) was the same in synaptosomes from both areas.	Glucose-6-Phosphate	59-62	hexokinase 1	Homo sapiens	21-23
29695157-3	2018	Though the physiological role of PMM2 is catalysis of the mutase reaction that provides the mannose 1-phosphate (Man-1-P) essential for protein glycosylation, PMM1 is thought to provide a phosphohydrolase activity in the presence of inosine monophosphate (IMP), converting glucose 1,6-bisphosphate (Glu-1,6-P2) to glucose 6-phosphate (Glu-6-P), rescuing glycolysis during brain ischemia.	Glucose-6-Phosphate	314-333	phosphomannomutase 2	Homo sapiens	33-37
29695157-3	2018	Though the physiological role of PMM2 is catalysis of the mutase reaction that provides the mannose 1-phosphate (Man-1-P) essential for protein glycosylation, PMM1 is thought to provide a phosphohydrolase activity in the presence of inosine monophosphate (IMP), converting glucose 1,6-bisphosphate (Glu-1,6-P2) to glucose 6-phosphate (Glu-6-P), rescuing glycolysis during brain ischemia.	Glucose-6-Phosphate	314-333	phosphomannomutase 1	Homo sapiens	159-163
29695157-3	2018	Though the physiological role of PMM2 is catalysis of the mutase reaction that provides the mannose 1-phosphate (Man-1-P) essential for protein glycosylation, PMM1 is thought to provide a phosphohydrolase activity in the presence of inosine monophosphate (IMP), converting glucose 1,6-bisphosphate (Glu-1,6-P2) to glucose 6-phosphate (Glu-6-P), rescuing glycolysis during brain ischemia.	Glucose-6-Phosphate	335-342	phosphomannomutase 2	Homo sapiens	33-37
29695157-3	2018	Though the physiological role of PMM2 is catalysis of the mutase reaction that provides the mannose 1-phosphate (Man-1-P) essential for protein glycosylation, PMM1 is thought to provide a phosphohydrolase activity in the presence of inosine monophosphate (IMP), converting glucose 1,6-bisphosphate (Glu-1,6-P2) to glucose 6-phosphate (Glu-6-P), rescuing glycolysis during brain ischemia.	Glucose-6-Phosphate	335-342	phosphomannomutase 1	Homo sapiens	159-163
29719821-4	2018	SLC37A1 and SLC37A2 are Pi-linked glucose-6-phosphate (G6P) antiporters, catalyzing both homologous (Pi/Pi) and heterologous (G6P/Pi) exchanges, whereas SLC37A3 transport properties remain to be clarified.	Glucose-6-Phosphate	34-53	solute carrier family 37 member 2	Homo sapiens	12-19
29719821-4	2018	SLC37A1 and SLC37A2 are Pi-linked glucose-6-phosphate (G6P) antiporters, catalyzing both homologous (Pi/Pi) and heterologous (G6P/Pi) exchanges, whereas SLC37A3 transport properties remain to be clarified.	Glucose-6-Phosphate	34-53	solute carrier family 37 member 3	Homo sapiens	153-160
29719821-8	2018	SLC37A4, also known as glucose-6-phosphate translocase (G6PT), transports G6P from the cytoplasm into the ER lumen, working in complex with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to Pi and glucose.	Glucose-6-Phosphate	56-59	solute carrier family 37 member 4	Homo sapiens	0-7
29719821-8	2018	SLC37A4, also known as glucose-6-phosphate translocase (G6PT), transports G6P from the cytoplasm into the ER lumen, working in complex with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to Pi and glucose.	Glucose-6-Phosphate	56-59	solute carrier family 37 member 4	Homo sapiens	23-54
29719821-8	2018	SLC37A4, also known as glucose-6-phosphate translocase (G6PT), transports G6P from the cytoplasm into the ER lumen, working in complex with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to Pi and glucose.	Glucose-6-Phosphate	56-59	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	147-174
29719821-8	2018	SLC37A4, also known as glucose-6-phosphate translocase (G6PT), transports G6P from the cytoplasm into the ER lumen, working in complex with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to Pi and glucose.	Glucose-6-Phosphate	56-59	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	176-188
29719821-8	2018	SLC37A4, also known as glucose-6-phosphate translocase (G6PT), transports G6P from the cytoplasm into the ER lumen, working in complex with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to Pi and glucose.	Glucose-6-Phosphate	56-59	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	193-204
29291405-5	2018	Also we found that NQO1 depletion significantly decreased the gene expression levels of hexokinase II (HKII), a key mediator of aerobic glycolysis responsible for the transformation of glucose into glucose-6-phosphate.	Glucose-6-Phosphate	198-217	NAD(P)H quinone dehydrogenase 1	Homo sapiens	19-23
29500232-4	2018	Defective BLVRB-regulated glutamine utilization was accompanied by exaggerated glycolytic accumulation of the rate-limiting hexokinase reaction product glucose-6-phosphate.	Glucose-6-Phosphate	152-171	biliverdin reductase B	Homo sapiens	10-15
29298880-4	2018	Here, we report the structure of HK2 in complex with glucose and glucose-6-phosphate (G6P).	Glucose-6-Phosphate	65-84	hexokinase 2	Homo sapiens	33-36
29298880-4	2018	Here, we report the structure of HK2 in complex with glucose and glucose-6-phosphate (G6P).	Glucose-6-Phosphate	86-89	hexokinase 2	Homo sapiens	33-36
29247711-3	2018	Hexokinase 2 (HK2) phosphorylates glucose to generate glucose-6-phosphate, the rate-limiting step in glycolysis.	Glucose-6-Phosphate	54-73	hexokinase 2	Homo sapiens	0-12
29247711-3	2018	Hexokinase 2 (HK2) phosphorylates glucose to generate glucose-6-phosphate, the rate-limiting step in glycolysis.	Glucose-6-Phosphate	54-73	hexokinase 2	Homo sapiens	14-17
29291405-5	2018	Also we found that NQO1 depletion significantly decreased the gene expression levels of hexokinase II (HKII), a key mediator of aerobic glycolysis responsible for the transformation of glucose into glucose-6-phosphate.	Glucose-6-Phosphate	198-217	hexokinase 2	Homo sapiens	88-101
29291405-5	2018	Also we found that NQO1 depletion significantly decreased the gene expression levels of hexokinase II (HKII), a key mediator of aerobic glycolysis responsible for the transformation of glucose into glucose-6-phosphate.	Glucose-6-Phosphate	198-217	hexokinase 2	Homo sapiens	103-107
29152106-4	2017	We disrupted the upstream glycolytic enzyme, glucose-6-phosphate isomerase (GPI), to allow cells to re-route glucose-6-phosphate flux into the pentose-phosphate branch.	Glucose-6-Phosphate	45-64	glucose-6-phosphate isomerase	Homo sapiens	76-79
28980855-4	2018	The autophagic degradation of HK2 (hexokinase 2), a crucial glycolytic enzyme catalyzing the conversion of glucose to glucose-6-phosphate, was found to be involved in the regulation of glycolysis by autophagy.	Glucose-6-Phosphate	118-137	hexokinase 2	Homo sapiens	30-33
28980855-4	2018	The autophagic degradation of HK2 (hexokinase 2), a crucial glycolytic enzyme catalyzing the conversion of glucose to glucose-6-phosphate, was found to be involved in the regulation of glycolysis by autophagy.	Glucose-6-Phosphate	118-137	hexokinase 2	Homo sapiens	35-47
29018835-9	2017	The changes in PME levels likely partly resulted from changes in G-6-P, one of the overlapping phosphomonoesters in the 31P MR spectra in vivo.	Glucose-6-Phosphate	65-70	cystatin B	Homo sapiens	15-18
29576889-2	2017	G6Pase-alpha catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate in the terminal step of gluconeogenesis and glycogenolysis, and is a key enzyme for endogenous glucose production.	Glucose-6-Phosphate	41-60	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-12
28206714-3	2017	MATERIALS AND METHODS: We used rat hepatocytes to test the hypothesis that GKAs raise hepatocyte glucose 6-phosphate (G6P, the glucokinase product) and down-stream metabolites with consequent repression of the liver glucokinase gene ( Gck).	Glucose-6-Phosphate	97-116	glucokinase	Rattus norvegicus	75-79
28600316-8	2017	By utilizing MalP and PGM to generate glucose 6-phosphate, we can avoid the addition of phosphate donors such as ATP, the use of which would not be practical for scaled-up production of myo-inositol.	Glucose-6-Phosphate	38-57	phosphoglucomutase	Solanum tuberosum	22-25
28206714-3	2017	MATERIALS AND METHODS: We used rat hepatocytes to test the hypothesis that GKAs raise hepatocyte glucose 6-phosphate (G6P, the glucokinase product) and down-stream metabolites with consequent repression of the liver glucokinase gene ( Gck).	Glucose-6-Phosphate	118-121	glucokinase	Rattus norvegicus	75-79
28743811-4	2017	The overall structures of Tps1 from Candida albicans and Aspergillus fumigatus are essentially identical and reveal N- and C-terminal Rossmann fold domains that form the glucose-6-phosphate and UDP-glucose substrate binding sites, respectively.	Glucose-6-Phosphate	170-189	alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1	Saccharomyces cerevisiae S288C	26-30
28775726-2	2017	A mutant, gpt2, lacking a chloroplast glucose-6-phosphate/phosphate translocator, is deficient in its ability to acclimate to increased light.	Glucose-6-Phosphate	38-57	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	10-14
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Glucose-6-Phosphate	144-163	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
28473643-10	2017	Under G6pd deficiency conditions, isocitrate dehydrogenase 1 likely functions as the principal source of NADPH for cytosolic antioxidant defense in the cochlea.SIGNIFICANCE STATEMENT Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Glucose-6-Phosphate	327-346	glucose-6-phosphate dehydrogenase 2	Mus musculus	6-10
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Glucose-6-Phosphate	144-163	glucose-6-phosphate dehydrogenase 2	Mus musculus	35-39
28473643-10	2017	Under G6pd deficiency conditions, isocitrate dehydrogenase 1 likely functions as the principal source of NADPH for cytosolic antioxidant defense in the cochlea.SIGNIFICANCE STATEMENT Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Glucose-6-Phosphate	327-346	glucose-6-phosphate dehydrogenase 2	Mus musculus	183-216
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Glucose-6-Phosphate	144-163	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	199-204
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Glucose-6-Phosphate	144-163	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	250-255
28473643-1	2017	Glucose-6-phosphate dehydrogenase (G6PD) is the first and rate-limiting enzyme of the pentose phosphate pathway; it catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconate and NADP+ to NADPH and is thought to be the principal source of NADPH for the cytosolic glutathione and thioredoxin antioxidant defense systems.	Glucose-6-Phosphate	144-163	thioredoxin 1	Mus musculus	290-301
27886975-4	2017	This pathway is comprised of glucose phosphorylation via polyphosphate glucokinase, NADH generation catalyzed by glucose 6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH), electron transfer from NADH to the anode, and glucose 6-phosphate regeneration via the non-oxidative pentose phosphate pathway and gluconeogenesis.	Glucose-6-Phosphate	113-132	glucose-6-phosphate dehydrogenase	Homo sapiens	148-153
28385800-7	2017	This can lead to enhanced FGF21 expression via elevated fatty acid synthesis, consequent to the inhibition of carnitine/palmitoyl-transferase by malonyl-CoA, and via increased glucose-6-phosphate-mediated activation of the carbohydrate response element binding protein, known to regulate FGF21 gene expression.	Glucose-6-Phosphate	176-195	fibroblast growth factor 21	Homo sapiens	26-31
28385800-7	2017	This can lead to enhanced FGF21 expression via elevated fatty acid synthesis, consequent to the inhibition of carnitine/palmitoyl-transferase by malonyl-CoA, and via increased glucose-6-phosphate-mediated activation of the carbohydrate response element binding protein, known to regulate FGF21 gene expression.	Glucose-6-Phosphate	176-195	MLX interacting protein like	Homo sapiens	223-268
28655753-3	2017	Glucokinase produces glucose 6-phosphate (G-6-P) in an irreversible reaction that determines glycolytic flux.	Glucose-6-Phosphate	21-40	glucokinase	Homo sapiens	0-11
28655753-3	2017	Glucokinase produces glucose 6-phosphate (G-6-P) in an irreversible reaction that determines glycolytic flux.	Glucose-6-Phosphate	42-47	glucokinase	Homo sapiens	0-11
28588557-6	2017	Interestingly, transcript levels of phosphoglucose isomerase 1 (PGI1), fructose 1,6-bisphosphate aldolase 1 and 2 (FBA1 and FBA2) were down-regulated in all mutants; PGI1, FBA1, and FBA2 act on downstream of glucose 6-phosphate conversion in glycolytic pathway.	Glucose-6-Phosphate	208-227	uncharacterized protein	Chlamydomonas reinhardtii	36-62
28588557-6	2017	Interestingly, transcript levels of phosphoglucose isomerase 1 (PGI1), fructose 1,6-bisphosphate aldolase 1 and 2 (FBA1 and FBA2) were down-regulated in all mutants; PGI1, FBA1, and FBA2 act on downstream of glucose 6-phosphate conversion in glycolytic pathway.	Glucose-6-Phosphate	208-227	uncharacterized protein	Chlamydomonas reinhardtii	64-68
28588557-6	2017	Interestingly, transcript levels of phosphoglucose isomerase 1 (PGI1), fructose 1,6-bisphosphate aldolase 1 and 2 (FBA1 and FBA2) were down-regulated in all mutants; PGI1, FBA1, and FBA2 act on downstream of glucose 6-phosphate conversion in glycolytic pathway.	Glucose-6-Phosphate	208-227	uncharacterized protein	Chlamydomonas reinhardtii	115-119
28588557-6	2017	Interestingly, transcript levels of phosphoglucose isomerase 1 (PGI1), fructose 1,6-bisphosphate aldolase 1 and 2 (FBA1 and FBA2) were down-regulated in all mutants; PGI1, FBA1, and FBA2 act on downstream of glucose 6-phosphate conversion in glycolytic pathway.	Glucose-6-Phosphate	208-227	uncharacterized protein	Chlamydomonas reinhardtii	124-128
28588557-6	2017	Interestingly, transcript levels of phosphoglucose isomerase 1 (PGI1), fructose 1,6-bisphosphate aldolase 1 and 2 (FBA1 and FBA2) were down-regulated in all mutants; PGI1, FBA1, and FBA2 act on downstream of glucose 6-phosphate conversion in glycolytic pathway.	Glucose-6-Phosphate	208-227	uncharacterized protein	Chlamydomonas reinhardtii	166-170
28588557-7	2017	Therefore, down-regulations of PGI1, FBA1, and FBA2 may lead to accumulation of upstream metabolites, notably glucose 6-phosphate, resulting in induction of PGM1 expression through feed-forward regulation and that PGM1 overexpression caused starch over-accumulation in mutants.	Glucose-6-Phosphate	110-129	uncharacterized protein	Chlamydomonas reinhardtii	31-35
28588557-7	2017	Therefore, down-regulations of PGI1, FBA1, and FBA2 may lead to accumulation of upstream metabolites, notably glucose 6-phosphate, resulting in induction of PGM1 expression through feed-forward regulation and that PGM1 overexpression caused starch over-accumulation in mutants.	Glucose-6-Phosphate	110-129	uncharacterized protein	Chlamydomonas reinhardtii	37-41
28588557-7	2017	Therefore, down-regulations of PGI1, FBA1, and FBA2 may lead to accumulation of upstream metabolites, notably glucose 6-phosphate, resulting in induction of PGM1 expression through feed-forward regulation and that PGM1 overexpression caused starch over-accumulation in mutants.	Glucose-6-Phosphate	110-129	uncharacterized protein	Chlamydomonas reinhardtii	47-51
27695030-1	2017	BACKGROUND: When Staphylococcus aureus is grown in the presence of high concentration of external glucose, this sugar is phosphorylated by glucokinase (glkA) to form glucose-6-phosphate.	Glucose-6-Phosphate	166-185	AT695_RS09780	Staphylococcus aureus	139-150
27695030-1	2017	BACKGROUND: When Staphylococcus aureus is grown in the presence of high concentration of external glucose, this sugar is phosphorylated by glucokinase (glkA) to form glucose-6-phosphate.	Glucose-6-Phosphate	166-185	AT695_RS09780	Staphylococcus aureus	152-156
27790731-9	2016	Specifically, metabolites from the nucleotide and amino acid pathway (ribose, glucose-6-phosphate, glutamic acid, aspartic acid, and sedoheptulose-7-P) were elevated in Shp-/- CD + M mice during the dark cycle, whereas metabolites including N-methylalanine, 2-hydroxybutyric acid, and 2-hydroxyglutarate were elevated in WT ED + E mice during the light cycle.	Glucose-6-Phosphate	78-97	nuclear receptor subfamily 0, group B, member 2	Mus musculus	169-172
27870481-1	2016	Glucokinase enhances glucose conversion to glucose-6-phosphate, causing glucose-stimulated insulin secretion from pancreatic beta cells and increased hepatic glucose uptake.	Glucose-6-Phosphate	43-62	insulin	Homo sapiens	91-98
27520373-4	2016	In hepatocytes, GCK catalyzes the phosphorylation of glucose into glucose-6-phosphate.	Glucose-6-Phosphate	66-85	glucokinase	Mus musculus	16-19
27669460-7	2016	We found that fructose-induced G6PC activity is a major determinant of hepatic glucose production and reduces hepatic glucose-6-phosphate levels to complete a homeostatic loop.	Glucose-6-Phosphate	118-137	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	31-35
27302990-7	2016	Activity of glycogen synthase (GS) without the allosteric activator glucose 6-phosphate (G6P) was decreased in AMPKgamma3(R200Q) relative to all other genotypes, whereas both AMPKgamma3(R200Q) and AMPKgamma3(R200Q) + RyR1(R615C) muscle exhibited increased GS activity with G6P.	Glucose-6-Phosphate	68-87	protein kinase AMP-activated non-catalytic subunit gamma 3	Sus scrofa	111-116
27302990-7	2016	Activity of glycogen synthase (GS) without the allosteric activator glucose 6-phosphate (G6P) was decreased in AMPKgamma3(R200Q) relative to all other genotypes, whereas both AMPKgamma3(R200Q) and AMPKgamma3(R200Q) + RyR1(R615C) muscle exhibited increased GS activity with G6P.	Glucose-6-Phosphate	89-92	protein kinase AMP-activated non-catalytic subunit gamma 3	Sus scrofa	111-116
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Glucose-6-Phosphate	209-228	hexokinase 1	Homo sapiens	51-53
27436961-6	2016	The significance of careful selection of enzyme activities-guided by RTMS-is exemplified in the synthesis of glucose-6-phosphate by hexokinase in the presence of a buffering enzyme, pyruvate kinase.	Glucose-6-Phosphate	109-128	hexokinase 1	Homo sapiens	132-142
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Glucose-6-Phosphate	209-228	fructose-bisphosphatase 1	Homo sapiens	113-117
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Glucose-6-Phosphate	209-228	phosphofructokinase, muscle	Homo sapiens	175-179
27153534-4	2016	Phosphorylation of these enzymes leads to enhanced HK activity to sustain glucose uptake but reduced activity of FBP1 to block the gluconeogenic route and reduced activity of PFK1 and ENO1 to moderate drop of glucose-6-phosphate and to repartition more carbon flux to pentose phosphate pathway (PPP), maintaining cellular energy and redox homeostasis at cellular and organismal levels.	Glucose-6-Phosphate	209-228	enolase 1	Homo sapiens	184-188
26555263-2	2016	ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases.	Glucose-6-Phosphate	44-63	ADP dependent glucokinase	Homo sapiens	0-25
26932234-8	2016	Our findings, therefore, suggest that induction of GPT2 expression by Suc increases the import of glucose-6-phosphate into the plastids that would repress chloroplast-encoded transcripts, restricting chloroplast differentiation.	Glucose-6-Phosphate	98-117	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	51-55
26972339-1	2016	Human phosphoglucomutase 1 (PGM1) plays a central role in cellular glucose homeostasis, mediating the switch between glycolysis and gluconeogenesis through the conversion of glucose 1-phosphate and glucose 6-phosphate.	Glucose-6-Phosphate	198-217	phosphoglucomutase 1	Homo sapiens	6-26
26972339-1	2016	Human phosphoglucomutase 1 (PGM1) plays a central role in cellular glucose homeostasis, mediating the switch between glycolysis and gluconeogenesis through the conversion of glucose 1-phosphate and glucose 6-phosphate.	Glucose-6-Phosphate	198-217	phosphoglucomutase 1	Homo sapiens	28-32
26860459-2	2016	In the endoplasmic reticulum (ER), the pyridine nucleotide redox state (NADP/NADPH) is dictated by the concentration of glucose-6-phosphate (G6P) and the coordinated activities of two enzymes, hexose-6-phosphate dehydrogenase (H6PDH) and 11beta-HSD1.	Glucose-6-Phosphate	120-139	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	193-225
26860459-2	2016	In the endoplasmic reticulum (ER), the pyridine nucleotide redox state (NADP/NADPH) is dictated by the concentration of glucose-6-phosphate (G6P) and the coordinated activities of two enzymes, hexose-6-phosphate dehydrogenase (H6PDH) and 11beta-HSD1.	Glucose-6-Phosphate	120-139	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	227-232
26860459-2	2016	In the endoplasmic reticulum (ER), the pyridine nucleotide redox state (NADP/NADPH) is dictated by the concentration of glucose-6-phosphate (G6P) and the coordinated activities of two enzymes, hexose-6-phosphate dehydrogenase (H6PDH) and 11beta-HSD1.	Glucose-6-Phosphate	120-139	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	238-249
25995077-0	2016	Demonstration of glucose-6-phosphate hydrogen 5 enrichment from deuterated water by transaldolase-mediated exchange alone.	Glucose-6-Phosphate	17-36	transaldolase 1	Homo sapiens	84-97
25995077-9	2016	CONCLUSION: Hydrogen 5 of G6P was enriched from (2)H2O through exchanges mediated by transaldolase.	Glucose-6-Phosphate	26-29	transaldolase 1	Homo sapiens	85-98
26555263-2	2016	ADP-dependent glucokinase (ADPGK) catalyzes glucose-6-phosphate production, utilizing ADP as a phosphoryl donor in contrast to the more well characterized ATP-requiring hexokinases.	Glucose-6-Phosphate	44-63	ADP dependent glucokinase	Homo sapiens	27-32
27051594-10	2016	The glucose 6-phosphatase system catalyzes the dephosphorylation of glucose 6-phosphate to glucose, a necessary step for free glucose to leave the cell.	Glucose-6-Phosphate	68-87	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	4-25
26869107-5	2016	The content of milk metabolites was significantly affected by the change in rations as milk glucose, glucose-6-phosphate, uric acid, and the ratio cholesterol: triacylglycerides increased with higher energy intake while BHBA and TAG decreased.	Glucose-6-Phosphate	101-120	Weaning weight-maternal milk	Bos taurus	15-19
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	124-143	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	17-28
26519772-8	2015	GPa to GPb interconversion is dependent on the conformational state of phosphorylase which can be relaxed (R) or tense (T) depending on the concentrations of allosteric effectors such as glucose, glucose 6-phosphate and adenine nucleotides and on the acetylation state of lysine residues.	Glucose-6-Phosphate	196-215	glycophorin B (MNS blood group)	Homo sapiens	7-10
26168779-6	2015	The rate of cellular glucose utilization in the brain is largely determined by hexokinase, which under basal conditions is more than 90 % inhibited by its product glucose-6-phosphate (Glc-6-P).	Glucose-6-Phosphate	163-182	hexokinase 1	Homo sapiens	79-89
26168779-6	2015	The rate of cellular glucose utilization in the brain is largely determined by hexokinase, which under basal conditions is more than 90 % inhibited by its product glucose-6-phosphate (Glc-6-P).	Glucose-6-Phosphate	184-191	hexokinase 1	Homo sapiens	79-89
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	124-143	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	66-98
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	124-143	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	100-105
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	124-143	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	180-191
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	145-148	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	17-28
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	145-148	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	66-98
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	145-148	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	100-105
26528718-5	2015	The direction of 11beta-HSD1 has been proposed to be regulated by hexose-6-phosphate dehydrogenase (H6PDH), which catalyzes glucose-6-phosphate (G6P) to generate NADPH that drives 11beta-HSD1 towards reduction.	Glucose-6-Phosphate	145-148	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	180-191
26528718-8	2015	S3483, a G6P transporter inhibitor, reversed the G6P-mediated increases of 11beta-HSD1 reductase activity.	Glucose-6-Phosphate	9-12	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	75-86
26116768-4	2015	In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion of glucose into glucose-6-phosphate, was induced by activated PI3K/Akt signaling.	Glucose-6-Phosphate	163-182	hexokinase 2	Homo sapiens	39-51
26579829-1	2015	Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate.	Glucose-6-Phosphate	172-191	glucose-6-phosphate isomerase	Homo sapiens	0-29
26579829-1	2015	Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate.	Glucose-6-Phosphate	172-191	glucose-6-phosphate isomerase	Homo sapiens	31-34
26579829-1	2015	Glucose-6-phosphate isomerase (GPI), also known as phosphoglucose isomerase, was initially identified as the second glycolytic enzyme that catalyzes the interconversion of glucose-6-phosphate to fructose-6-phosphate.	Glucose-6-Phosphate	172-191	glucose-6-phosphate isomerase	Homo sapiens	51-75
26054020-7	2015	MicroRNA-199a-5p directly targets the 3"-untranslated region of hexokinase 2 (HK2), an enzyme that catalyzes the irreversible first step of glycolysis, thereby suppressing glucose consumption, lactate production, cellular glucose-6-phosphate and adenosine triphosphate levels, cell proliferation, and tumorigenesis of liver cancer cells.	Glucose-6-Phosphate	222-241	hexokinase 2	Homo sapiens	64-76
26054020-7	2015	MicroRNA-199a-5p directly targets the 3"-untranslated region of hexokinase 2 (HK2), an enzyme that catalyzes the irreversible first step of glycolysis, thereby suppressing glucose consumption, lactate production, cellular glucose-6-phosphate and adenosine triphosphate levels, cell proliferation, and tumorigenesis of liver cancer cells.	Glucose-6-Phosphate	222-241	hexokinase 2	Homo sapiens	78-81
26116768-4	2015	In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion of glucose into glucose-6-phosphate, was induced by activated PI3K/Akt signaling.	Glucose-6-Phosphate	163-182	hexokinase 2	Homo sapiens	53-56
26116768-4	2015	In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion of glucose into glucose-6-phosphate, was induced by activated PI3K/Akt signaling.	Glucose-6-Phosphate	163-182	AKT serine/threonine kinase 1	Homo sapiens	214-217
26023239-5	2015	Moreover, a comprehensive metabolomics analysis revealed that the levels of glucose 6-phosphate and 6-phosphogluconate as early metabolites in glycolysis and PPP were decreased after inhibition of the PI3K/AKT/mTOR pathway, suggesting a link between PI3K signaling and the proper function of glucose transporters or hexokinases in glycolysis.	Glucose-6-Phosphate	76-95	AKT serine/threonine kinase 1	Homo sapiens	206-209
26023239-5	2015	Moreover, a comprehensive metabolomics analysis revealed that the levels of glucose 6-phosphate and 6-phosphogluconate as early metabolites in glycolysis and PPP were decreased after inhibition of the PI3K/AKT/mTOR pathway, suggesting a link between PI3K signaling and the proper function of glucose transporters or hexokinases in glycolysis.	Glucose-6-Phosphate	76-95	mechanistic target of rapamycin kinase	Homo sapiens	210-214
25811607-1	2015	Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	73-92	phosphoglucose isomerase 1	Arabidopsis thaliana	0-24
25474495-0	2015	Acclimation of metabolism to light in Arabidopsis thaliana: the glucose 6-phosphate/phosphate translocator GPT2 directs metabolic acclimation.	Glucose-6-Phosphate	64-83	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	107-111
25474495-2	2015	In Arabidopsis thaliana, this dynamic acclimation requires expression of GPT2, a glucose 6-phosphate/phosphate translocator.	Glucose-6-Phosphate	81-100	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	73-77
25474495-6	2015	We suggest that GPT2 activity results in the net import of glucose 6-phosphate from cytosol to chloroplast, increasing starch synthesis.	Glucose-6-Phosphate	59-78	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	16-20
25552595-2	2015	Studies of G6pc2 knockout (KO) mice suggest that G6pc2 represents a negative regulator of basal glucose-stimulated insulin secretion (GSIS) that acts by hydrolyzing glucose-6-phosphate (G6P), thereby reducing glycolytic flux.	Glucose-6-Phosphate	165-184	glucose-6-phosphatase, catalytic, 2	Mus musculus	49-54
25552595-2	2015	Studies of G6pc2 knockout (KO) mice suggest that G6pc2 represents a negative regulator of basal glucose-stimulated insulin secretion (GSIS) that acts by hydrolyzing glucose-6-phosphate (G6P), thereby reducing glycolytic flux.	Glucose-6-Phosphate	186-189	glucose-6-phosphatase, catalytic, 2	Mus musculus	11-16
25552595-2	2015	Studies of G6pc2 knockout (KO) mice suggest that G6pc2 represents a negative regulator of basal glucose-stimulated insulin secretion (GSIS) that acts by hydrolyzing glucose-6-phosphate (G6P), thereby reducing glycolytic flux.	Glucose-6-Phosphate	186-189	glucose-6-phosphatase, catalytic, 2	Mus musculus	49-54
25716920-6	2015	D-Glucose-6-phosphate (D-G6P), which is generated from D-FBP in the gluconeogenesis pathway, produces D-ribose-5-phosphate (D-R5P) in the pentose phosphate pathway.	Glucose-6-Phosphate	0-21	ECB2	Homo sapiens	57-60
25716920-6	2015	D-Glucose-6-phosphate (D-G6P), which is generated from D-FBP in the gluconeogenesis pathway, produces D-ribose-5-phosphate (D-R5P) in the pentose phosphate pathway.	Glucose-6-Phosphate	23-28	ECB2	Homo sapiens	57-60
25288127-2	2015	G6Pase-alpha and G6Pase-beta are glucose-6-phosphate (G6P) hydrolases with active sites lying inside the endoplasmic reticulum (ER) lumen and as such are dependent upon the G6PT to translocate G6P from the cytoplasm into the lumen.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	173-177
25582303-5	2015	These findings support the hypothesis of trehalose-6-phosphate as the effector of a negative feedback system, similar to the inhibition of hexokinase by glucose-6-phosphate in mammalian cells and controlling glycolytic flux.	Glucose-6-Phosphate	153-172	hexokinase 1	Homo sapiens	139-149
25204670-5	2015	Major determinants of HK2 dissociation are the elevated glucose-6-phosphate concentrations and decreased pH in ischaemia.	Glucose-6-Phosphate	56-75	hexokinase 2	Homo sapiens	22-25
25527037-4	2015	Biochemical analysis, including activity ratio (in the absence relative to that in the presence of glucose-6-phosphate) measurement, covalently attached phosphate estimation as well as phosphatase treatment, revealed that recombinant GYS1 is substantially more heavily phosphorylated than would be observed in intact human or rodent muscle tissues.	Glucose-6-Phosphate	99-118	glycogen synthase 1	Homo sapiens	234-238
26299854-2	2015	Glucokinase (GK), an enzyme that catalyzes the conversion of glucose to glucose-6-phosphate in pancreatic ss-cells, liver hepatocytes, specific hypothalamic neurons, and intestine enterocytes, is a key regulator of glucose homeostasis.	Glucose-6-Phosphate	72-91	glucokinase	Homo sapiens	0-11
26299854-2	2015	Glucokinase (GK), an enzyme that catalyzes the conversion of glucose to glucose-6-phosphate in pancreatic ss-cells, liver hepatocytes, specific hypothalamic neurons, and intestine enterocytes, is a key regulator of glucose homeostasis.	Glucose-6-Phosphate	72-91	glucokinase	Homo sapiens	13-15
25774549-4	2015	However, rat islets exhibited a more pronounced glucose-provoked increase of glutamate, glycerol-3-phosphate, succinate, and lactate levels, whereas INS-1 832/13 cells showed a higher glucose-elicited increase in glucose-6-phosphate, alanine, isocitrate, and alpha-ketoglutarate levels.	Glucose-6-Phosphate	213-232	insulin 1	Rattus norvegicus	149-154
25817793-1	2015	Glucokinase is expressed principally in pancreatic beta-cells and hepatocytes, and catalyzes the phosphorylation of glucose to glucose-6-phosphate, a rate-limiting step of glycolysis.	Glucose-6-Phosphate	127-146	glucokinase	Mus musculus	0-11
29124141-1	2015	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate and fructose 6-phosphate in the glycolysis pathway.	Glucose-6-Phosphate	69-88	glucose-6-phosphate isomerase	Homo sapiens	0-24
29124141-1	2015	Phosphoglucose isomerase (PGI) catalyzes the interconversion between glucose 6-phosphate and fructose 6-phosphate in the glycolysis pathway.	Glucose-6-Phosphate	69-88	glucose-6-phosphate isomerase	Homo sapiens	26-29
25811607-1	2015	Phosphoglucose isomerase (PGI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	73-92	phosphoglucose isomerase 1	Arabidopsis thaliana	26-29
25647035-3	2015	In the late phase of apoptosis, glucose-6-phosphate accumulation in the cell causes the dissociation of the two proteins, the re-opening of the channel and the recovery of VDAC1 function, resulting in a reawakening of the mitochondrial function, thus inevitably leading to cell death.	Glucose-6-Phosphate	32-51	voltage dependent anion channel 1	Homo sapiens	172-177
25492228-2	2015	G6Pase-beta is an enzyme embedded in the endoplasmic reticulum membrane that catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate.	Glucose-6-Phosphate	105-124	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	0-11
26075875-1	2015	Hexokinase is the first enzyme in the glycolytic pathway catalyzing the reaction in which glucose is phosphorylated into glucose-6-phosphate.	Glucose-6-Phosphate	121-140	hexokinase 1	Homo sapiens	0-10
25602755-4	2015	We hypothesized that HIV-1 protects infected macrophages from apoptosis in part by modulating the host glycolytic pathway specifically by regulating hexokinase-1 (HK-1) an enzyme that converts glucose to glucose-6-phosphate.	Glucose-6-Phosphate	204-223	hexokinase 1	Homo sapiens	163-167
26278433-1	2014	Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which is known to be an inhibitor of the enzyme.	Glucose-6-Phosphate	155-174	hexokinase 1	Homo sapiens	184-194
25401493-1	2014	Phosphoglucomutase (PGM) catalyses the interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P) and exists as plastidial (pPGM) and cytosolic (cPGM) isoforms.	Glucose-6-Phosphate	88-107	phosphoglucomutase	Arabidopsis thaliana	0-18
25401493-1	2014	Phosphoglucomutase (PGM) catalyses the interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P) and exists as plastidial (pPGM) and cytosolic (cPGM) isoforms.	Glucose-6-Phosphate	88-107	phosphoglucomutase	Arabidopsis thaliana	20-23
25401493-1	2014	Phosphoglucomutase (PGM) catalyses the interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P) and exists as plastidial (pPGM) and cytosolic (cPGM) isoforms.	Glucose-6-Phosphate	109-112	phosphoglucomutase	Arabidopsis thaliana	0-18
25401493-1	2014	Phosphoglucomutase (PGM) catalyses the interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P) and exists as plastidial (pPGM) and cytosolic (cPGM) isoforms.	Glucose-6-Phosphate	109-112	phosphoglucomutase	Arabidopsis thaliana	20-23
25709214-5	2015	In liver, AMPK decreases glucose production mainly through the downregulation of the key gluconeogenesis enzymes such as phosphoenolpyruvate carboxylase (PEPCK) and Glucose -6-phosphate (G6Pase).	Glucose-6-Phosphate	165-185	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	187-193
26278433-1	2014	Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which is known to be an inhibitor of the enzyme.	Glucose-6-Phosphate	155-174	hexokinase 1	Homo sapiens	196-198
26278433-1	2014	Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which is known to be an inhibitor of the enzyme.	Glucose-6-Phosphate	176-179	hexokinase 1	Homo sapiens	184-194
26278433-1	2014	Dissolution dynamic nuclear polarization (D-DNP) experiments enabled us to study the kinetics of the enzymatic phosphorylation reaction of glucose to form glucose-6-phosphate (G6P) by hexokinase (HK), with or without the presence of an excess of G6P, which is known to be an inhibitor of the enzyme.	Glucose-6-Phosphate	176-179	hexokinase 1	Homo sapiens	196-198
25122863-0	2014	Evaluation of disk potentiation test using kirby-bauer disks containing high-dosage fosfomycin and glucose-6-phosphate to detect production of glutathione S-transferase responsible for fosfomycin resistance.	Glucose-6-Phosphate	99-118	glutathione S-transferase kappa 1	Homo sapiens	143-168
25104722-2	2014	Thus, the hexose phosphate pools of the cytosol and the chloroplast represent important metabolic resources that are maintained through action of phosphoglucose isomerase (PGI) and phosphoglucose mutase interconverting glucose 6-phosphate, fructose 6-phosphate, and glucose 1-phosphate.	Glucose-6-Phosphate	219-238	phosphoglucose isomerase 1	Arabidopsis thaliana	146-170
25905030-6	2014	HepG2 cells cultured in low extracellular Mg2+ presented a 20% decrease in total cellular Mg2+ content, reduced glucose accumulation, and enhanced glucose 6-phosphate (G6P) transport into the endoplasmic reticulum (ER).	Glucose-6-Phosphate	147-166	mucolipin TRP cation channel 1	Homo sapiens	42-45
25905030-6	2014	HepG2 cells cultured in low extracellular Mg2+ presented a 20% decrease in total cellular Mg2+ content, reduced glucose accumulation, and enhanced glucose 6-phosphate (G6P) transport into the endoplasmic reticulum (ER).	Glucose-6-Phosphate	168-171	mucolipin TRP cation channel 1	Homo sapiens	42-45
25104722-2	2014	Thus, the hexose phosphate pools of the cytosol and the chloroplast represent important metabolic resources that are maintained through action of phosphoglucose isomerase (PGI) and phosphoglucose mutase interconverting glucose 6-phosphate, fructose 6-phosphate, and glucose 1-phosphate.	Glucose-6-Phosphate	219-238	phosphoglucose isomerase 1	Arabidopsis thaliana	172-175
25190649-9	2014	Hexokinase 1 catalyzes phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	53-72	hexokinase 1	Homo sapiens	0-12
24952355-1	2014	Phosphoglucomutase (PGM)1 catalyzes the reversible conversion reaction between glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P).	Glucose-6-Phosphate	111-130	phosphoglucomutase 1	Homo sapiens	20-25
24447076-3	2014	The kinetics of pure GK showed enzyme activity of 0.423+-0.02 microM glucose-6-phosphate (G6P)/mL/Min and Km value of 6.66+-0.02 microM.	Glucose-6-Phosphate	69-88	glucokinase	Homo sapiens	21-23
24952355-1	2014	Phosphoglucomutase (PGM)1 catalyzes the reversible conversion reaction between glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P).	Glucose-6-Phosphate	132-137	phosphoglucomutase 1	Homo sapiens	20-25
24952355-6	2014	Our results suggest that PGM1 is required for sustained cell growth during nutritional changes, probably through regulating the balance of G-1-P and G-6-P in order to satisfy the cellular demands during nutritional stress.	Glucose-6-Phosphate	149-154	phosphoglucomutase 1	Homo sapiens	25-29
24987120-7	2014	Hexokinase, the first regulatory enzyme to initiate glycolysis by converting glucose to glucose-6-phosphate, contains a strong PAR-binding motif.	Glucose-6-Phosphate	88-107	hexokinase 1	Homo sapiens	0-10
25041126-8	2014	Nrf1 repressed insulin-regulated glycolysis-related gene expression and gave rise to loss of glucose-6-phosphate and fructose-6-phosphate contents in liver.	Glucose-6-Phosphate	93-112	nuclear factor, erythroid derived 2,-like 1	Mus musculus	0-4
25052436-4	2014	High and significant correlations among the concentrations of lactose, glucose, glucose-6-posphate, milk related respiratory index (the ratio between the concentrations of citrate/lactate+malate in milk) and milk-derived glycolytic index (the ratio between glucose-6-phosphate and glucose in milk) and milk clotting parameters were found.	Glucose-6-Phosphate	257-276	Weaning weight-maternal milk	Bos taurus	100-104
24632713-3	2014	The present results demonstrate that GO-203 and BTZ synergistically downregulate expression of the p53-inducible regulator of glycolysis and apoptosis (TIGAR), which promotes shunting of glucose-6-phosphate into the pentose phosphate pathway to generate reduced glutathione (GSH).	Glucose-6-Phosphate	187-206	tumor protein p53	Homo sapiens	99-102
24817585-4	2014	For the structural analysis of the protein, a comparative homology model was prepared on the basis of percentage sequence identity and substrate similarity using the crystal structure of human aldose reductase in complex with glucose-6-phosphate and NADP(+) (PDB ID: 2ACQ) as a template.	Glucose-6-Phosphate	226-245	aldo-keto reductase family 1 member B	Homo sapiens	193-209
24858947-3	2014	Glucokinase converts glucose to glucose-6-phosphate and determines glucose flux into the beta-cells and hepatocytes.	Glucose-6-Phosphate	32-51	glucokinase	Rattus norvegicus	0-11
24632713-3	2014	The present results demonstrate that GO-203 and BTZ synergistically downregulate expression of the p53-inducible regulator of glycolysis and apoptosis (TIGAR), which promotes shunting of glucose-6-phosphate into the pentose phosphate pathway to generate reduced glutathione (GSH).	Glucose-6-Phosphate	187-206	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	152-157
24631573-1	2014	We have reported that Mg(2+) dynamically regulates glucose 6-phosphate entry into the endoplasmic reticulum and its hydrolysis by the glucose 6-phosphatase in liver cells.	Glucose-6-Phosphate	51-70	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	134-155
24565827-1	2014	Glycogen storage disease type Ib (GSD-Ib) is an autosomal-recessive syndrome characterized by neutropenia and impaired glucose homeostasis resulting from a deficiency in the glucose-6-phosphate (G6P) transporter (G6PT).	Glucose-6-Phosphate	174-193	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	213-217
24565827-3	2014	Previously, we showed G6PT interacts with the enzyme glucose-6-phosphatase-beta (G6Pase-beta) to regulate the availability of G6P/glucose in neutrophils.	Glucose-6-Phosphate	22-25	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	81-92
24631573-7	2014	These and previously published results suggest that in an hepatocyte culture model changes in cytoplasmic Mg(2+) content regulates glucose 6-phosphate utilization via glucose 6 phosphatase and hexose-6 phosphate dehydrogenase in alternative to glycolysis and glycogen synthesis.	Glucose-6-Phosphate	131-150	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	167-188
24489010-0	2014	GPT2: a glucose 6-phosphate/phosphate translocator with a novel role in the regulation of sugar signalling during seedling development.	Glucose-6-Phosphate	8-27	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	0-4
24731772-4	2014	Glucokinase activators (GKAs) are novel agents for diabetes which act by enhancing the formation of glucose-6-phosphate leading to increased insulin production and subsequent suppression of blood glucose.	Glucose-6-Phosphate	100-119	glucokinase	Rattus norvegicus	0-11
24503893-5	2014	METHODS AND RESULTS: In a mouse model of N488I mutation of the Prkag2 gene (R2M), we rescued the glycogen storage phenotype by genetic inhibition of glucose-6-phosphate-stimulated glycogen synthase activity.	Glucose-6-Phosphate	149-168	protein kinase, AMP-activated, gamma 2 non-catalytic subunit	Mus musculus	63-69
24646511-1	2014	Glycogen storage disease type 1b (GSD1b) is an inherited metabolic defect of glycogenolysis and gluconeogenesis due to mutations of the SLC37A4 gene and to defective transport of glucose-6-phosphate.	Glucose-6-Phosphate	179-198	solute carrier family 37 member 4	Homo sapiens	34-39
24489010-1	2014	BACKGROUND AND AIMS: GPT2, a glucose 6-phosphate/phosphate translocator, plays an important role in environmental sensing in mature leaves of Arabidopsis thaliana.	Glucose-6-Phosphate	29-48	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	21-25
24745989-2	2014	Three of the four members, SLC37A1, SLC37A2, and SLC37A4, function as Pi-linked glucose-6-phosphate (G6P) antiporters catalyzing G6P:P(i) and P(i):P(i) exchanges.	Glucose-6-Phosphate	101-104	solute carrier family 37 member 4	Homo sapiens	49-56
24577087-7	2014	Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS.	Glucose-6-Phosphate	89-108	hexokinase 2	Homo sapiens	44-55
24577087-7	2014	Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS.	Glucose-6-Phosphate	89-108	hexokinase 2	Homo sapiens	57-60
24577087-7	2014	Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS.	Glucose-6-Phosphate	110-113	hexokinase 2	Homo sapiens	44-55
24577087-7	2014	Increasing glucose metabolism by expressing hexokinase2 (HK2), which converts glucose to glucose-6-phosphate (G6P), favors escape from OIS.	Glucose-6-Phosphate	110-113	hexokinase 2	Homo sapiens	57-60
24533087-1	2014	Glucokinase (GK) is a hexokinase isozyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	90-109	glucokinase	Rattus norvegicus	0-11
24533087-1	2014	Glucokinase (GK) is a hexokinase isozyme that catalyzes the phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	90-109	glucokinase	Rattus norvegicus	13-15
24056026-1	2014	Glucokinase (GK), an enzyme that phosphorylates glucose to form glucose-6-phosphate, has a role in regulating insulin secretion and proliferation in beta cells.	Glucose-6-Phosphate	64-83	glucokinase	Homo sapiens	0-11
24056026-1	2014	Glucokinase (GK), an enzyme that phosphorylates glucose to form glucose-6-phosphate, has a role in regulating insulin secretion and proliferation in beta cells.	Glucose-6-Phosphate	64-83	glucokinase	Homo sapiens	13-15
24696842-1	2014	OBJECTIVES: Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	102-121	glucokinase	Homo sapiens	12-23
24696842-1	2014	OBJECTIVES: Glucokinase encoded by GCK is a key enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	102-121	glucokinase	Homo sapiens	35-38
24745989-2	2014	Three of the four members, SLC37A1, SLC37A2, and SLC37A4, function as Pi-linked glucose-6-phosphate (G6P) antiporters catalyzing G6P:P(i) and P(i):P(i) exchanges.	Glucose-6-Phosphate	80-99	solute carrier family 37 member 1	Homo sapiens	27-34
24745989-2	2014	Three of the four members, SLC37A1, SLC37A2, and SLC37A4, function as Pi-linked glucose-6-phosphate (G6P) antiporters catalyzing G6P:P(i) and P(i):P(i) exchanges.	Glucose-6-Phosphate	80-99	solute carrier family 37 member 2	Homo sapiens	36-43
24745989-2	2014	Three of the four members, SLC37A1, SLC37A2, and SLC37A4, function as Pi-linked glucose-6-phosphate (G6P) antiporters catalyzing G6P:P(i) and P(i):P(i) exchanges.	Glucose-6-Phosphate	80-99	solute carrier family 37 member 4	Homo sapiens	49-56
24745989-2	2014	Three of the four members, SLC37A1, SLC37A2, and SLC37A4, function as Pi-linked glucose-6-phosphate (G6P) antiporters catalyzing G6P:P(i) and P(i):P(i) exchanges.	Glucose-6-Phosphate	101-104	solute carrier family 37 member 1	Homo sapiens	27-34
24745989-2	2014	Three of the four members, SLC37A1, SLC37A2, and SLC37A4, function as Pi-linked glucose-6-phosphate (G6P) antiporters catalyzing G6P:P(i) and P(i):P(i) exchanges.	Glucose-6-Phosphate	101-104	solute carrier family 37 member 2	Homo sapiens	36-43
24142699-4	2013	We show that the absence of Epm2aip1 in mice impairs allosteric activation of GS by glucose 6-phosphate, decreases hepatic glycogen synthesis, increases liver fat, causes hepatic insulin resistance, and protects against age-related obesity.	Glucose-6-Phosphate	84-103	EPM2A (laforin) interacting protein 1	Mus musculus	28-36
23934573-3	2014	G6PD may be also involved in another inconsistent result of lowered intracellular lactate level in aripiprazole-treated PC12 cells, because PPP competes glucose-6-phosphate with the glycolytic pathway, resulting in the downregulation of glycolysis.	Glucose-6-Phosphate	153-172	glucose-6-phosphate dehydrogenase	Rattus norvegicus	0-4
25052034-2	2014	Conversion of glucose to glucose-6-phosphate by GK promotes glycogen synthesis in liver hepatocytes, and insulin release in the pancreatic beta-cells.	Glucose-6-Phosphate	25-44	glucokinase	Homo sapiens	48-50
23990365-2	2013	Liver glycogen synthase (GYS2), a key enzyme in glycogen synthesis, is controlled by a complex interplay between the allosteric activator glucose-6-phosphate (G6P) and reversible phosphorylation through glycogen synthase kinase-3 and the glycogen-associated form of protein phosphatase 1.	Glucose-6-Phosphate	138-157	glycogen synthase 2	Mus musculus	25-29
23990365-2	2013	Liver glycogen synthase (GYS2), a key enzyme in glycogen synthesis, is controlled by a complex interplay between the allosteric activator glucose-6-phosphate (G6P) and reversible phosphorylation through glycogen synthase kinase-3 and the glycogen-associated form of protein phosphatase 1.	Glucose-6-Phosphate	159-162	glycogen synthase 2	Mus musculus	25-29
23990365-3	2013	Here, we initially performed mutagenesis analysis and identified a key residue (Arg(582)) required for activation of GYS2 by G6P.	Glucose-6-Phosphate	125-128	glycogen synthase 2	Mus musculus	117-121
24226772-2	2013	Glucokinase (GK), a key enzyme that regulates glucose homeostasis, converts glucose to glucose-6-phosphate in pancreatic beta-cells, liver hepatocytes, specific hypothalamic neurons, and gut enterocytes.	Glucose-6-Phosphate	87-106	glucokinase	Homo sapiens	0-11
24226772-2	2013	Glucokinase (GK), a key enzyme that regulates glucose homeostasis, converts glucose to glucose-6-phosphate in pancreatic beta-cells, liver hepatocytes, specific hypothalamic neurons, and gut enterocytes.	Glucose-6-Phosphate	87-106	glucokinase	Homo sapiens	13-15
24142592-3	2013	This conclusion is supported by studies on G6pc2 knockout (KO) mice showing that G6pc2 represents a negative regulator of basal glucose-stimulated insulin secretion that acts by hydrolyzing glucose-6-phosphate, thereby reducing glycolytic flux and opposing the action of glucokinase.	Glucose-6-Phosphate	190-209	glucose-6-phosphatase, catalytic, 2	Mus musculus	81-86
23816435-1	2013	Glucokinase (GK) acts as a glucose sensor by facilitating glucose phosphorylation into glucose-6-phosphate (G6P) in the liver and pancreas, the two key target tissues.	Glucose-6-Phosphate	87-106	glucokinase	Rattus norvegicus	0-11
24095944-0	2013	alpha-Bromophosphonate analogs of glucose-6-phosphate are inhibitors of glucose-6-phosphatase.	Glucose-6-Phosphate	34-53	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	72-93
24095944-2	2013	Synthetic analogs of the G6Pase substrate, glucose-6-phosphate (G6P), may provide new tools to probe enzyme activity, or lead to specific inhibitors of glycosylphosphatase enzymes.	Glucose-6-Phosphate	43-62	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	25-31
24120122-7	2013	Chia seed reversed the impaired insulin stimulated glycogen synthase activity, glycogen, glucose-6-phosphate and GLUT-4 protein levels as well as insulin resistance and dyslipidemia.	Glucose-6-Phosphate	89-108	chitinase, acidic	Rattus norvegicus	0-4
23816435-1	2013	Glucokinase (GK) acts as a glucose sensor by facilitating glucose phosphorylation into glucose-6-phosphate (G6P) in the liver and pancreas, the two key target tissues.	Glucose-6-Phosphate	87-106	glucokinase	Rattus norvegicus	13-15
23816435-1	2013	Glucokinase (GK) acts as a glucose sensor by facilitating glucose phosphorylation into glucose-6-phosphate (G6P) in the liver and pancreas, the two key target tissues.	Glucose-6-Phosphate	108-111	glucokinase	Rattus norvegicus	0-11
23816435-1	2013	Glucokinase (GK) acts as a glucose sensor by facilitating glucose phosphorylation into glucose-6-phosphate (G6P) in the liver and pancreas, the two key target tissues.	Glucose-6-Phosphate	108-111	glucokinase	Rattus norvegicus	13-15
23648263-3	2013	We have reported a G6P biosensor based on screen-printed electrode using Prussian Blue (PB) nanoparticles and enzymes, glucose-6-phosphate dehydrogenase, and glutathione reductase.	Glucose-6-Phosphate	19-22	glucose-6-phosphate dehydrogenase	Homo sapiens	119-152
23665046-4	2013	Intracellularly, two compartmentalized reactions generate NADPH upon oxidation of glucose-6-phosphate: cytosolic glucose-6-phosphate dehydrogenase and microsomal hexose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	82-101	glucose-6-phosphate dehydrogenase	Homo sapiens	113-146
23836898-7	2013	Glucose 6-phosphate (G-6P), a product of the catalytic activity of HK-II, is well known to dissociate HK-II from mitochondria.	Glucose-6-Phosphate	0-19	hexokinase 2	Rattus norvegicus	67-72
23836898-7	2013	Glucose 6-phosphate (G-6P), a product of the catalytic activity of HK-II, is well known to dissociate HK-II from mitochondria.	Glucose-6-Phosphate	0-19	hexokinase 2	Rattus norvegicus	102-107
23836898-7	2013	Glucose 6-phosphate (G-6P), a product of the catalytic activity of HK-II, is well known to dissociate HK-II from mitochondria.	Glucose-6-Phosphate	21-25	hexokinase 2	Rattus norvegicus	67-72
23836898-7	2013	Glucose 6-phosphate (G-6P), a product of the catalytic activity of HK-II, is well known to dissociate HK-II from mitochondria.	Glucose-6-Phosphate	21-25	hexokinase 2	Rattus norvegicus	102-107
23836898-8	2013	Addition of G-6P to isolated mitochondria dose-dependently dissociates WT HK-II, and this response is inhibited significantly in mitochondria isolated from cardiomyocytes expressing T473D HK-II.	Glucose-6-Phosphate	12-16	hexokinase 2	Rattus norvegicus	74-79
23836898-8	2013	Addition of G-6P to isolated mitochondria dose-dependently dissociates WT HK-II, and this response is inhibited significantly in mitochondria isolated from cardiomyocytes expressing T473D HK-II.	Glucose-6-Phosphate	12-16	hexokinase 2	Rattus norvegicus	188-193
23836898-9	2013	Pretreatment with IGF-1 also inhibits G-6P-induced overexpressed or endogenous HK-II dissociation, and this response was blocked by Akt inhibition.	Glucose-6-Phosphate	38-42	insulin-like growth factor 1	Rattus norvegicus	18-23
23836898-9	2013	Pretreatment with IGF-1 also inhibits G-6P-induced overexpressed or endogenous HK-II dissociation, and this response was blocked by Akt inhibition.	Glucose-6-Phosphate	38-42	hexokinase 2	Rattus norvegicus	79-84
23836898-9	2013	Pretreatment with IGF-1 also inhibits G-6P-induced overexpressed or endogenous HK-II dissociation, and this response was blocked by Akt inhibition.	Glucose-6-Phosphate	38-42	AKT serine/threonine kinase 1	Rattus norvegicus	132-135
23648263-3	2013	We have reported a G6P biosensor based on screen-printed electrode using Prussian Blue (PB) nanoparticles and enzymes, glucose-6-phosphate dehydrogenase, and glutathione reductase.	Glucose-6-Phosphate	19-22	glutathione-disulfide reductase	Homo sapiens	158-179
23825378-1	2013	Glucose phosphate isomerase (GPI) involves in the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate in glucose pathways.	Glucose-6-Phosphate	78-97	glucose-6-phosphate isomerase	Gallus gallus	0-27
23825378-1	2013	Glucose phosphate isomerase (GPI) involves in the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate in glucose pathways.	Glucose-6-Phosphate	78-97	glucose-6-phosphate isomerase	Gallus gallus	29-32
23631812-1	2013	The MondoA-Mlx transcription complex plays a pivotal role in glucose homoeostasis by activating target gene expression in response to G6P (glucose 6-phosphate), the first reaction intermediate in glycolysis.	Glucose-6-Phosphate	134-137	MLX interacting protein	Homo sapiens	4-10
23631812-1	2013	The MondoA-Mlx transcription complex plays a pivotal role in glucose homoeostasis by activating target gene expression in response to G6P (glucose 6-phosphate), the first reaction intermediate in glycolysis.	Glucose-6-Phosphate	134-137	MAX dimerization protein MLX	Homo sapiens	11-14
23631812-1	2013	The MondoA-Mlx transcription complex plays a pivotal role in glucose homoeostasis by activating target gene expression in response to G6P (glucose 6-phosphate), the first reaction intermediate in glycolysis.	Glucose-6-Phosphate	139-158	MLX interacting protein	Homo sapiens	4-10
23631812-1	2013	The MondoA-Mlx transcription complex plays a pivotal role in glucose homoeostasis by activating target gene expression in response to G6P (glucose 6-phosphate), the first reaction intermediate in glycolysis.	Glucose-6-Phosphate	139-158	MAX dimerization protein MLX	Homo sapiens	11-14
23631812-8	2013	Secondly, MondoA-Mlx complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP-dependent feedback inhibition of glycolysis.	Glucose-6-Phosphate	56-59	MLX interacting protein	Homo sapiens	10-16
23631812-8	2013	Secondly, MondoA-Mlx complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP-dependent feedback inhibition of glycolysis.	Glucose-6-Phosphate	56-59	MAX dimerization protein MLX	Homo sapiens	17-20
23631812-8	2013	Secondly, MondoA-Mlx complexes sense elevated levels of G6P and adenine nucleotides to trigger a TXNIP-dependent feedback inhibition of glycolysis.	Glucose-6-Phosphate	56-59	thioredoxin interacting protein	Homo sapiens	97-102
23823480-5	2013	These data show that (1) the immediate action of insulin to suppress hepatic glucose production functions via an Akt2-dependent redirection of glucose-6-phosphate to glycogen, and (2) insulin increases glucose phosphorylation and conversion to glycogen independent of GSK3.	Glucose-6-Phosphate	143-162	thymoma viral proto-oncogene 2	Mus musculus	113-117
22976764-5	2013	Functional testing and clinical analyses suggested a deficiency in the interconversion of glucose-1-phosphate and glucose-6-phosphate catalyzed by phosphoglucomutase (PGM1), a defect previously described as glycogenosis type XIV (GSDXIV, MIM 612934).	Glucose-6-Phosphate	114-133	phosphoglucomutase 1	Homo sapiens	167-171
23274894-9	2013	These data suggest that G6pc2 represents a novel, negative regulator of basal GSIS that acts by hydrolyzing glucose-6-phosphate, thereby reducing glycolytic flux.	Glucose-6-Phosphate	108-127	glucose-6-phosphatase, catalytic, 2	Mus musculus	24-29
23686371-3	2013	We now tested the hypothesis that inotropic stimulation and increased afterload also regulate mTOR activation via glucose 6-phosphate (G6P) accumulation.	Glucose-6-Phosphate	114-133	mechanistic target of rapamycin kinase	Homo sapiens	94-98
23686371-3	2013	We now tested the hypothesis that inotropic stimulation and increased afterload also regulate mTOR activation via glucose 6-phosphate (G6P) accumulation.	Glucose-6-Phosphate	135-138	mechanistic target of rapamycin kinase	Homo sapiens	94-98
23885364-1	2010	PKM2 is directly oxidized on Cys(358) to inhibit its catalytic activity, which allows for diversion of glucose-6-phosphate into the pentose phosphate pathway.	Glucose-6-Phosphate	103-122	pyruvate kinase M1/2	Homo sapiens	0-4
23126339-5	2013	Treatment with insulin increased levels of basal or glucose (25 mM)-induced MG and glucose 6-phosphate.	Glucose-6-Phosphate	83-102	insulin	Homo sapiens	15-22
23400775-2	2013	We found previously that increased carbon flux from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 and suppress cell death pathways.	Glucose-6-Phosphate	52-71	calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog	Xenopus laevis	207-213
23506893-5	2013	G6PT translocates G6P from the cytoplasm into the lumen of the ER where it couples with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to glucose and Pi.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	95-122
23506893-5	2013	G6PT translocates G6P from the cytoplasm into the lumen of the ER where it couples with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to glucose and Pi.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	124-136
23506893-5	2013	G6PT translocates G6P from the cytoplasm into the lumen of the ER where it couples with either glucose-6-phosphatase-alpha (G6Pase-alpha) or G6Pase-beta to hydrolyze intraluminal G6P to glucose and Pi.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	141-152
23400775-2	2013	We found previously that increased carbon flux from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 and suppress cell death pathways.	Glucose-6-Phosphate	52-71	caspase 2 L homeolog	Xenopus laevis	241-250
23400775-2	2013	We found previously that increased carbon flux from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 and suppress cell death pathways.	Glucose-6-Phosphate	73-76	calcium/calmodulin dependent protein kinase (CaM kinase) II alpha S homeolog	Xenopus laevis	207-213
23400775-2	2013	We found previously that increased carbon flux from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADPH levels and calcium/calmodulin regulated protein kinase II (CaMKII) activity to phosphorylate caspase 2 and suppress cell death pathways.	Glucose-6-Phosphate	73-76	caspase 2 L homeolog	Xenopus laevis	241-250
23266497-1	2013	BACKGROUND: The endoplasmic reticulum enzyme glucose-6-phosphatase catalyzes the hydrolysis of glucose-6-phosphate to glucose and inorganic phosphate.	Glucose-6-Phosphate	95-114	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	45-66
23266497-2	2013	The enzyme is a part of a multicomponent system that includes several integral membrane proteins; the catalytic subunit (G6PC) and transporters for glucose-6-phosphate, inorganic phosphate and glucose.	Glucose-6-Phosphate	148-167	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	121-125
23266497-9	2013	Beside the well known key role in blood glucose homeostasis, the members of the G6PC family seem to play a role as sensors of intracellular glucose and of intraluminal glucose/glucose-6-phosphate in the endoplasmic reticulum.	Glucose-6-Phosphate	176-195	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	80-84
22958133-1	2013	BACKGROUND: Hydrolysis of glucose 6-phosphate (G6P) via glucose 6-phosphatase (G6Pase) enlarges the reticular Ca(2+) pool of the hepatocyte.	Glucose-6-Phosphate	26-45	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	56-77
23023104-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, converting glucose-6-phosphate to 6-phosphoglucono-delta-lactone with parallel reduction of NADP(+).	Glucose-6-Phosphate	104-123	glucose-6-phosphate dehydrogenase	Homo sapiens	0-33
23023104-1	2013	Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway, converting glucose-6-phosphate to 6-phosphoglucono-delta-lactone with parallel reduction of NADP(+).	Glucose-6-Phosphate	104-123	glucose-6-phosphate dehydrogenase	Homo sapiens	35-39
23164509-4	2013	Here, we demonstrate distinctive increases in glucose uptake, glucose-6-phosphate formation, lactate release, and glycogen formation in K8/K18 IF-lacking hepatocytes and/or hepatoma cells versus their respective IF-containing counterparts.	Glucose-6-Phosphate	62-81	keratin 8	Homo sapiens	136-145
23257075-3	2013	Glucose 6-phosphate (G6P) can also inhibit SnRK1 and given the similarity in structure to T6P, we sought to establish if each could impart distinct inhibition of SnRK1.	Glucose-6-Phosphate	0-19	snRK1	Triticum aestivum	43-48
23257075-3	2013	Glucose 6-phosphate (G6P) can also inhibit SnRK1 and given the similarity in structure to T6P, we sought to establish if each could impart distinct inhibition of SnRK1.	Glucose-6-Phosphate	21-24	snRK1	Triticum aestivum	43-48
22958133-1	2013	BACKGROUND: Hydrolysis of glucose 6-phosphate (G6P) via glucose 6-phosphatase (G6Pase) enlarges the reticular Ca(2+) pool of the hepatocyte.	Glucose-6-Phosphate	26-45	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	79-85
22958133-1	2013	BACKGROUND: Hydrolysis of glucose 6-phosphate (G6P) via glucose 6-phosphatase (G6Pase) enlarges the reticular Ca(2+) pool of the hepatocyte.	Glucose-6-Phosphate	47-50	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	56-77
22958133-1	2013	BACKGROUND: Hydrolysis of glucose 6-phosphate (G6P) via glucose 6-phosphatase (G6Pase) enlarges the reticular Ca(2+) pool of the hepatocyte.	Glucose-6-Phosphate	47-50	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	79-85
23476789-1	2013	Glucokinase (GK) is the predominant hexokinase that acts as glucose sensor and catalyses the formation of Glucose-6-phosphate.	Glucose-6-Phosphate	106-125	glucokinase	Homo sapiens	0-11
23519063-0	2013	Cloning, expression and characterization of glucokinase gene involved in the glucose-6- phosphate formation in Staphylococcus aureus.	Glucose-6-Phosphate	77-97	AT695_RS09780	Staphylococcus aureus	44-55
23519063-1	2013	Glucose-6-phosphate (G-6-P) formation in Staphylococcus aureus is catalysed by glucokinase (glkA) gene under high glucose concentration leading to upregulation of various pathogenic factors; therefore the present study is aimed in the cloning and characterization of glk A gene from S. aureus ATCC12600.	Glucose-6-Phosphate	0-19	AT695_RS09780	Staphylococcus aureus	79-90
23519063-1	2013	Glucose-6-phosphate (G-6-P) formation in Staphylococcus aureus is catalysed by glucokinase (glkA) gene under high glucose concentration leading to upregulation of various pathogenic factors; therefore the present study is aimed in the cloning and characterization of glk A gene from S. aureus ATCC12600.	Glucose-6-Phosphate	21-26	AT695_RS09780	Staphylococcus aureus	79-90
23476789-1	2013	Glucokinase (GK) is the predominant hexokinase that acts as glucose sensor and catalyses the formation of Glucose-6-phosphate.	Glucose-6-Phosphate	106-125	glucokinase	Homo sapiens	13-15
23476789-1	2013	Glucokinase (GK) is the predominant hexokinase that acts as glucose sensor and catalyses the formation of Glucose-6-phosphate.	Glucose-6-Phosphate	106-125	hexokinase 1	Homo sapiens	36-46
23457523-6	2013	The GAA(-/-) mouse strains were found to have elevated glycogen synthase (GS), glycogenin, hexokinase, and glucose-6-phosphate (G-6-P, the allosteric activator of GS).	Glucose-6-Phosphate	107-126	glucosidase, alpha, acid	Mus musculus	4-7
23257733-1	2013	Whether glucose-6-phosphate (G6P) or xylulose-5-phosphate (X5P) is the signaling molecule for carbohydrate response element binding protein (ChREBP) transactivation has been controversial.	Glucose-6-Phosphate	8-27	MLX interacting protein-like	Rattus norvegicus	94-139
23257733-1	2013	Whether glucose-6-phosphate (G6P) or xylulose-5-phosphate (X5P) is the signaling molecule for carbohydrate response element binding protein (ChREBP) transactivation has been controversial.	Glucose-6-Phosphate	8-27	MLX interacting protein-like	Rattus norvegicus	141-147
23257733-1	2013	Whether glucose-6-phosphate (G6P) or xylulose-5-phosphate (X5P) is the signaling molecule for carbohydrate response element binding protein (ChREBP) transactivation has been controversial.	Glucose-6-Phosphate	29-32	MLX interacting protein-like	Rattus norvegicus	94-139
23257733-1	2013	Whether glucose-6-phosphate (G6P) or xylulose-5-phosphate (X5P) is the signaling molecule for carbohydrate response element binding protein (ChREBP) transactivation has been controversial.	Glucose-6-Phosphate	29-32	MLX interacting protein-like	Rattus norvegicus	141-147
23573289-2	2013	In the liver, phosphorylation of glucose to glucose-6-phosphate by GCK is the first step for both glycolysis and glycogen synthesis.	Glucose-6-Phosphate	44-63	glucokinase	Homo sapiens	67-70
23457523-6	2013	The GAA(-/-) mouse strains were found to have elevated glycogen synthase (GS), glycogenin, hexokinase, and glucose-6-phosphate (G-6-P, the allosteric activator of GS).	Glucose-6-Phosphate	128-133	glucosidase, alpha, acid	Mus musculus	4-7
22855938-3	2012	Trehalose biosynthesis in plants involves a two-step reaction in which trehalose-6-phosphate (T6P) is synthesized from UDP-glucose and glucose-6-phosphate (catalyzed by T6P synthase [TPS]), and subsequently dephosphorylated to produce the disaccharide trehalose (catalyzed by T6P phosphatase [TPP]).	Glucose-6-Phosphate	135-154	thylakoid processing peptide	Arabidopsis thaliana	276-291
23797762-3	2013	Critical to this phenotype is the production of glucose-6-phosphate (G6P), catalysed by hexokinases (HK) I and II, whose role in glucose retention and metabolism is highly advantageous for cell survival and proliferation.	Glucose-6-Phosphate	48-67	hexokinase 1	Homo sapiens	88-113
23797762-3	2013	Critical to this phenotype is the production of glucose-6-phosphate (G6P), catalysed by hexokinases (HK) I and II, whose role in glucose retention and metabolism is highly advantageous for cell survival and proliferation.	Glucose-6-Phosphate	69-72	hexokinase 1	Homo sapiens	88-113
23256222-16	2004	The HKs, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in the transport of glucose into cells through the facilitative glucose transporters (GLUT1-GLUT13) (11).	Glucose-6-Phosphate	34-53	solute carrier family 2 member 1	Homo sapiens	190-195
23149230-1	2012	Glucokinase is a key enzyme in glucose homeostasis since it phosphorylates glucose to give glucose-6-phosphate, which is the first step in glycolysis.	Glucose-6-Phosphate	91-110	glucokinase	Homo sapiens	0-11
23166963-15	2004	The HKs, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in the transport of glucose into cells through the facilitative glucose transporters (GLUT1-13) (11).	Glucose-6-Phosphate	34-53	solute carrier family 2 member 1	Homo sapiens	190-195
22422504-2	2012	G6Pase-alpha activity depends on the G6P transporter (G6PT) that translocates G6P from the cytoplasm into the ER lumen.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase, catalytic	Mus musculus	37-52
22422504-2	2012	G6Pase-alpha activity depends on the G6P transporter (G6PT) that translocates G6P from the cytoplasm into the ER lumen.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase, catalytic	Mus musculus	54-58
22855938-3	2012	Trehalose biosynthesis in plants involves a two-step reaction in which trehalose-6-phosphate (T6P) is synthesized from UDP-glucose and glucose-6-phosphate (catalyzed by T6P synthase [TPS]), and subsequently dephosphorylated to produce the disaccharide trehalose (catalyzed by T6P phosphatase [TPP]).	Glucose-6-Phosphate	135-154	thylakoid processing peptide	Arabidopsis thaliana	293-296
22762304-2	2012	In this study, we report the functional heterologous expression of Drosophila melanogaster TPS, the gene identification, full length cDNA cloning and functional expression of cat flea (Ctenocephalides felis) TPS, and the Michaelis-Menten constants for their specific substrates glucose-6-phosphate and uridinediphosphate-glucose.	Glucose-6-Phosphate	278-297	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	91-94
22438109-3	2012	We find that the glucose-6-phosphate (G6P) and pseudo catabolic/anabolic branch points are flexible in the D: -ribose-producing tkt deficient strain of B. pumilus.	Glucose-6-Phosphate	17-36	AKO65_RS14630	Bacillus pumilus	128-131
22438109-3	2012	We find that the glucose-6-phosphate (G6P) and pseudo catabolic/anabolic branch points are flexible in the D: -ribose-producing tkt deficient strain of B. pumilus.	Glucose-6-Phosphate	38-41	AKO65_RS14630	Bacillus pumilus	128-131
22699485-3	2012	Glucose phosphate isomerase (GPI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	76-95	glucose-6-phosphate isomerase	Gallus gallus	0-27
22699485-3	2012	Glucose phosphate isomerase (GPI) catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	76-95	glucose-6-phosphate isomerase	Gallus gallus	29-32
22214556-2	2012	Allosteric mechanisms involving glucose 6-phosphate or xylulose 5-phosphate and covalent modification of ChREBP (carbohydrate-response element-binding protein) have been implicated in this mechanism.	Glucose-6-Phosphate	32-51	MLX interacting protein like	Homo sapiens	113-158
21983240-1	2012	Glucose-6 phosphatase (G6Pase), a key enzyme of glucose homeostasis, catalyses the hydrolysis of glucose-6 phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	97-116	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	187-194	glycogen synthase 1	Rattus norvegicus	19-23
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	187-194	glycogen synthase 2	Rattus norvegicus	27-31
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	187-194	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	35-39
21983240-1	2012	Glucose-6 phosphatase (G6Pase), a key enzyme of glucose homeostasis, catalyses the hydrolysis of glucose-6 phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	23-26	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	152-159	glycogen synthase 1	Rattus norvegicus	19-23
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	152-159	glycogen synthase 2	Rattus norvegicus	27-31
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	152-159	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	35-39
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	161-180	glycogen synthase 1	Rattus norvegicus	19-23
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	161-180	glycogen synthase 2	Rattus norvegicus	27-31
22233421-3	2012	Phosphorylation of GYS1 or GYS2 by AMPK led to enzyme inactivation by decreasing the affinity for both UDP-Glc (UDP-glucose) [assayed in the absence of Glc-6-P (glucose-6-phosphate)] and Glc-6-P (assayed at low UDP-Glc concentrations).	Glucose-6-Phosphate	161-180	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	35-39
22107947-3	2012	Mammalian glucokinase is subject to homotropic allosteric regulation by glucose-the steady-state velocity of glucose-6-phosphate production is not hyperbolic, but instead displays a sigmoidal response to increasing glucose concentrations.	Glucose-6-Phosphate	109-128	glucokinase	Homo sapiens	10-21
21983240-1	2012	Glucose-6 phosphatase (G6Pase), a key enzyme of glucose homeostasis, catalyses the hydrolysis of glucose-6 phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	97-116	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	23-29
22382780-5	2012	At its mitochondrial location HK2 binds at/near the protein VDAC (voltage dependent anion channel), escapes inhibition by its product glucose-6-phosphate, and gains access to mitochondrial produced ATP.	Glucose-6-Phosphate	134-153	hexokinase 2	Homo sapiens	30-33
22085411-4	2012	We synthesized caged molecules of nicotinamide adenine dinucleotide phosphate (NADP(+)) and glucose 6-phosphate (G6P), which are involved in the generation of NADPH (cofactor of P450).	Glucose-6-Phosphate	92-111	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	178-182
22322891-10	2012	Inhibition of mt-HK II by glucose-6-phosphate retards the mitochondria to react with 3-BrPA.	Glucose-6-Phosphate	26-45	hexokinase 2	Homo sapiens	17-22
22085411-4	2012	We synthesized caged molecules of nicotinamide adenine dinucleotide phosphate (NADP(+)) and glucose 6-phosphate (G6P), which are involved in the generation of NADPH (cofactor of P450).	Glucose-6-Phosphate	113-116	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	178-182
21835137-0	2012	Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver.	Glucose-6-Phosphate	0-19	MLX interacting protein like	Homo sapiens	89-95
22101819-1	2011	Glucokinase (GK) catalyses the formation of glucose 6-phosphate from glucose and ATP.	Glucose-6-Phosphate	44-63	glucokinase	Homo sapiens	0-11
22101819-1	2011	Glucokinase (GK) catalyses the formation of glucose 6-phosphate from glucose and ATP.	Glucose-6-Phosphate	44-63	glucokinase	Homo sapiens	13-15
22102256-1	2011	An N-terminally truncated version of the enzyme glucose-6-phosphate dehydrogenase from Trypanosoma cruzi lacking the first 37 residues was crystallized both in its apo form and in a binary complex with glucose 6-phosphate.	Glucose-6-Phosphate	202-221	glucose-6-phosphate dehydrogenase	Homo sapiens	48-81
21787864-12	2011	Combined, these data suggest that GPI deficiency results in an accumulation of glucose-6-phosphate, and possibly other glucose-derived metabolites, leading to activation of mTOR and sequestration of lipin 1 to the cytosol, preventing its proper functioning.	Glucose-6-Phosphate	79-98	mechanistic target of rapamycin kinase	Homo sapiens	173-177
21908621-2	2011	The MondoA Mlx transcription factor is glucose-responsive and accumulates in the nucleus by sensing glucose 6-phosphate.	Glucose-6-Phosphate	100-119	MAX-like protein X	Mus musculus	11-14
21787864-12	2011	Combined, these data suggest that GPI deficiency results in an accumulation of glucose-6-phosphate, and possibly other glucose-derived metabolites, leading to activation of mTOR and sequestration of lipin 1 to the cytosol, preventing its proper functioning.	Glucose-6-Phosphate	79-98	lipin 1	Homo sapiens	199-206
21729692-1	2011	Myo-inositol-1-phosphate synthase (MIPS) catalyzes the conversion of glucose-6-phosphate to myo-inositol-1-phosphate.	Glucose-6-Phosphate	69-88	myo-inositol-1-phosphate synthase 1	Arabidopsis thaliana	0-33
22049574-8	2004	The HKs, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in the transport of glucose into cells through the facilitative glucose transporters (GLUT1-13) (3).	Glucose-6-Phosphate	34-53	solute carrier family 2 member 1	Homo sapiens	190-195
21729692-1	2011	Myo-inositol-1-phosphate synthase (MIPS) catalyzes the conversion of glucose-6-phosphate to myo-inositol-1-phosphate.	Glucose-6-Phosphate	69-88	myo-inositol-1-phosphate synthase 1	Arabidopsis thaliana	35-39
20615072-3	2011	Activation of FOXO1 in liver induces gluconeogenesis via phosphoenolpyruvate carboxykinase (PEPCK)/glucose 6-phosphate pathway, and disrupts mitochondrial metabolism and lipid metabolism via heme oxygenase 1/sirtuin 1/Ppargc1alpha pathway.	Glucose-6-Phosphate	99-118	forkhead box O1	Mus musculus	14-19
21491251-7	2011	G6Pase and PEPCK activities were determined by glucose 6-phosphate and malic acid substrate methods, respectively.	Glucose-6-Phosphate	47-66	phosphoenolpyruvate carboxykinase 1	Gallus gallus	11-16
21884983-5	2011	Furthermore, 14-3-3zeta is acetylated prior to caspase activation, and supplementation of Xenopus egg extract with glucose-6-phosphate, which promotes caspase-2/14-3-3zeta binding, enhances 14-3-3zeta-directed Sirtuin activity.	Glucose-6-Phosphate	115-134	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta L homeolog	Xenopus laevis	13-23
21884983-5	2011	Furthermore, 14-3-3zeta is acetylated prior to caspase activation, and supplementation of Xenopus egg extract with glucose-6-phosphate, which promotes caspase-2/14-3-3zeta binding, enhances 14-3-3zeta-directed Sirtuin activity.	Glucose-6-Phosphate	115-134	caspase 2	Homo sapiens	47-54
21884983-5	2011	Furthermore, 14-3-3zeta is acetylated prior to caspase activation, and supplementation of Xenopus egg extract with glucose-6-phosphate, which promotes caspase-2/14-3-3zeta binding, enhances 14-3-3zeta-directed Sirtuin activity.	Glucose-6-Phosphate	115-134	caspase 2	Mus musculus	151-160
21884983-5	2011	Furthermore, 14-3-3zeta is acetylated prior to caspase activation, and supplementation of Xenopus egg extract with glucose-6-phosphate, which promotes caspase-2/14-3-3zeta binding, enhances 14-3-3zeta-directed Sirtuin activity.	Glucose-6-Phosphate	115-134	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	161-171
21884983-5	2011	Furthermore, 14-3-3zeta is acetylated prior to caspase activation, and supplementation of Xenopus egg extract with glucose-6-phosphate, which promotes caspase-2/14-3-3zeta binding, enhances 14-3-3zeta-directed Sirtuin activity.	Glucose-6-Phosphate	115-134	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	161-171
21884983-5	2011	Furthermore, 14-3-3zeta is acetylated prior to caspase activation, and supplementation of Xenopus egg extract with glucose-6-phosphate, which promotes caspase-2/14-3-3zeta binding, enhances 14-3-3zeta-directed Sirtuin activity.	Glucose-6-Phosphate	115-134	sirtuin 2 S homeolog	Xenopus laevis	210-217
21492096-1	2011	With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation of key enzymes which govern the ratio of the pyridine nucleotide NADPH/NADP.	Glucose-6-Phosphate	39-42	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	68-73
21492096-1	2011	With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation of key enzymes which govern the ratio of the pyridine nucleotide NADPH/NADP.	Glucose-6-Phosphate	39-42	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	75-107
21492096-1	2011	With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation of key enzymes which govern the ratio of the pyridine nucleotide NADPH/NADP.	Glucose-6-Phosphate	44-63	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	68-73
21492096-1	2011	With the exception of the oxidation of G6P (glucose 6-phosphate) by H6PDH (hexose-6-phosphate dehydrogenase), scant information is available about other endogenous substrates affecting the redox state or the regulation of key enzymes which govern the ratio of the pyridine nucleotide NADPH/NADP.	Glucose-6-Phosphate	44-63	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	75-107
21490074-1	2011	BACKGROUND/AIMS: Glucokinase (GCK) phosphorylates glucose to form glucose 6-phosphate and thereby regulates hepatic glucose disposal and activates hepatic lipogenesis.	Glucose-6-Phosphate	66-85	glucokinase	Homo sapiens	17-28
21490074-1	2011	BACKGROUND/AIMS: Glucokinase (GCK) phosphorylates glucose to form glucose 6-phosphate and thereby regulates hepatic glucose disposal and activates hepatic lipogenesis.	Glucose-6-Phosphate	66-85	glucokinase	Homo sapiens	30-33
21491491-4	2011	The allosteric binding sites for aspartate (an inhibitor) and glucose-6-phosphate (an activator) observed in the Escherichia coli and Zea mays phosphoenolpyruvate carboxylase structures, respectively, are not conserved in the C. perfringens structure.	Glucose-6-Phosphate	62-81	MLO-like protein 4	Zea mays	143-174
21205021-1	2011	OBJECTIVE: in type 2 diabetic patients and their first-degree relatives, insulin resistance (IR) is associated with impairment of insulin-stimulated myocellular glucose-6-phosphate (g6p) and unidirectional flux through ATP synthase (fATP), suggesting the presence of inherited abnormal mitochondrial oxidative fitness.	Glucose-6-Phosphate	161-180	insulin	Homo sapiens	73-80
21163329-5	2011	Also, glucose-6-phosphate (G6P) had a positive regulation on H6PDH and 11beta-HSD1 in hepatocytes.	Glucose-6-Phosphate	6-25	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	61-66
21163329-5	2011	Also, glucose-6-phosphate (G6P) had a positive regulation on H6PDH and 11beta-HSD1 in hepatocytes.	Glucose-6-Phosphate	6-25	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	71-82
21163329-5	2011	Also, glucose-6-phosphate (G6P) had a positive regulation on H6PDH and 11beta-HSD1 in hepatocytes.	Glucose-6-Phosphate	27-30	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	61-66
21163329-5	2011	Also, glucose-6-phosphate (G6P) had a positive regulation on H6PDH and 11beta-HSD1 in hepatocytes.	Glucose-6-Phosphate	27-30	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	71-82
20506195-10	2011	BCAA administration enhanced the bioactivity of the glucose-sensing apparatus, probably via the activation of a transcriptional mechanism, suggesting that these amino acids may improve glucose metabolism through the accelerated utility of glucose and glucose-6-phosphate in the liver.	Glucose-6-Phosphate	251-270	AT-rich interaction domain 4B	Homo sapiens	0-4
21106871-1	2011	Glucose-6-phosphate (G6P) metabolism by the enzyme hexose-6-phosphate dehydrogenase (H6PDH) within the sarcoplasmic reticulum lumen generates nicotinamide adenine dinucleotide phosphate (reduced) to provide the redox potential for the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) to activate glucocorticoid (GC).	Glucose-6-Phosphate	0-19	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	242-284
21106871-1	2011	Glucose-6-phosphate (G6P) metabolism by the enzyme hexose-6-phosphate dehydrogenase (H6PDH) within the sarcoplasmic reticulum lumen generates nicotinamide adenine dinucleotide phosphate (reduced) to provide the redox potential for the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) to activate glucocorticoid (GC).	Glucose-6-Phosphate	0-19	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	286-297
21106871-1	2011	Glucose-6-phosphate (G6P) metabolism by the enzyme hexose-6-phosphate dehydrogenase (H6PDH) within the sarcoplasmic reticulum lumen generates nicotinamide adenine dinucleotide phosphate (reduced) to provide the redox potential for the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) to activate glucocorticoid (GC).	Glucose-6-Phosphate	21-24	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	242-284
21106871-1	2011	Glucose-6-phosphate (G6P) metabolism by the enzyme hexose-6-phosphate dehydrogenase (H6PDH) within the sarcoplasmic reticulum lumen generates nicotinamide adenine dinucleotide phosphate (reduced) to provide the redox potential for the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) to activate glucocorticoid (GC).	Glucose-6-Phosphate	21-24	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	286-297
21949678-7	2011	We show that SLC37A1 and SLC37A2 are ER-associated, P(i)-linked antiporters, that can transport G6P.	Glucose-6-Phosphate	96-99	solute carrier family 37 member 1	Homo sapiens	13-20
21949678-7	2011	We show that SLC37A1 and SLC37A2 are ER-associated, P(i)-linked antiporters, that can transport G6P.	Glucose-6-Phosphate	96-99	solute carrier family 37 member 2	Homo sapiens	25-32
20659277-0	2010	The plastidial glucose-6-phosphate/phosphate antiporter GPT1 is essential for morphogenesis in Arabidopsis embryos.	Glucose-6-Phosphate	15-34	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	56-60
20977462-11	2010	Furthermore, curcumin stimulated glucokinase activity, increasing conversion of glucose to G-6-P.	Glucose-6-Phosphate	91-96	glucokinase	Homo sapiens	33-44
20623219-7	2010	CONCLUSIONS/INTERPRETATIONS: These findings indicate that the absence of glucokinase inhibition by glucose 6-phosphate probably led to increased glycolysis and blocked glyceroneogenesis in the mouse model.	Glucose-6-Phosphate	99-118	glucokinase	Mus musculus	73-84
20975743-3	2010	G6Pase-alpha and G6Pase-beta are G6P hydrolases in the membrane of the endoplasmic reticulum, which depend on G6PT to transport G6P from the cytoplasm into the lumen.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	110-114
20498302-1	2010	G6PC3 deficiency, characterized by neutropenia and neutrophil dysfunction, is caused by deficiencies in the endoplasmic reticulum (ER) enzyme glucose-6-phosphatase-beta (G6Pase-beta or G6PC3) that converts glucose-6-phosphate (G6P) into glucose, the primary energy source of neutrophils.	Glucose-6-Phosphate	206-225	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	0-5
20498302-1	2010	G6PC3 deficiency, characterized by neutropenia and neutrophil dysfunction, is caused by deficiencies in the endoplasmic reticulum (ER) enzyme glucose-6-phosphatase-beta (G6Pase-beta or G6PC3) that converts glucose-6-phosphate (G6P) into glucose, the primary energy source of neutrophils.	Glucose-6-Phosphate	206-225	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	170-181
20498302-1	2010	G6PC3 deficiency, characterized by neutropenia and neutrophil dysfunction, is caused by deficiencies in the endoplasmic reticulum (ER) enzyme glucose-6-phosphatase-beta (G6Pase-beta or G6PC3) that converts glucose-6-phosphate (G6P) into glucose, the primary energy source of neutrophils.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	170-181
20498302-1	2010	G6PC3 deficiency, characterized by neutropenia and neutrophil dysfunction, is caused by deficiencies in the endoplasmic reticulum (ER) enzyme glucose-6-phosphatase-beta (G6Pase-beta or G6PC3) that converts glucose-6-phosphate (G6P) into glucose, the primary energy source of neutrophils.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 3	Homo sapiens	185-190
20826560-4	2010	Here, we show that fructose-6-phosphate (F6P) can substitute for G6P and is sufficient to maintain reductase activity of 11beta-HSD1 in isolated microsomes.	Glucose-6-Phosphate	65-68	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	121-132
20826560-5	2010	Our findings indicate that the mechanisms of F6P and G6P transport across the ER membrane are distinct and provide evidence that F6P is converted to G6P in the ER lumen, thus yielding substrate for H6PD-dependent reduced nicotinamide adenine dinucleotide phosphate generation.	Glucose-6-Phosphate	53-56	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	198-202
20659277-1	2010	The glucose-6-phosphate/phosphate antiporter GPT1 is a major route of entry of carbon into non-photosynthetic plastids.	Glucose-6-Phosphate	4-23	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	45-49
20659277-7	2010	We propose that GPT1 is necessary for early embryo development because it catalyses import into plastids of glucose-6-phosphate as the substrate for NADPH generation via the oxidative pentose phosphate pathway.	Glucose-6-Phosphate	108-127	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	16-20
20382127-0	2010	Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP).	Glucose-6-Phosphate	0-19	MLX interacting protein like	Homo sapiens	88-94
20359473-1	2010	BACKGROUND: Galactose-1-phosphate:uridyltransferase (GALT) catalyses the conversion of galactose-1-phosphate (Gal-1-P) and UDP-glucose (UDP-Glc) into glucose-6-phosphate and UDP-galactose (UDP-Gal).	Glucose-6-Phosphate	150-169	galactose-1-phosphate uridylyltransferase	Homo sapiens	12-51
20359473-1	2010	BACKGROUND: Galactose-1-phosphate:uridyltransferase (GALT) catalyses the conversion of galactose-1-phosphate (Gal-1-P) and UDP-glucose (UDP-Glc) into glucose-6-phosphate and UDP-galactose (UDP-Gal).	Glucose-6-Phosphate	150-169	galactose-1-phosphate uridylyltransferase	Homo sapiens	53-57
20505214-6	2010	A combination of metabolites that increased in plasma in response to exercise (glycerol, niacinamide, glucose-6-phosphate, pantothenate, and succinate) up-regulated the expression of nur77, a transcriptional regulator of glucose utilization and lipid metabolism genes in skeletal muscle in vitro.	Glucose-6-Phosphate	102-121	nuclear receptor subfamily 4 group A member 1	Homo sapiens	183-188
20507616-3	2010	The gene PGM2 encodes the last enzyme of the Leloir pathway, phosphoglucomutase 2 (Pgm2p), which catalyses the reversible conversion of glucose 1-phosphate to glucose 6-phosphate.	Glucose-6-Phosphate	159-178	phosphoglucomutase PGM2	Saccharomyces cerevisiae S288C	9-13
20507616-3	2010	The gene PGM2 encodes the last enzyme of the Leloir pathway, phosphoglucomutase 2 (Pgm2p), which catalyses the reversible conversion of glucose 1-phosphate to glucose 6-phosphate.	Glucose-6-Phosphate	159-178	phosphoglucomutase PGM2	Saccharomyces cerevisiae S288C	83-88
20382127-8	2010	These multiple lines of evidence support the conclusion that G-6-P mediates the activation of ChREBP.	Glucose-6-Phosphate	61-66	MLX interacting protein like	Homo sapiens	94-100
20712627-3	2010	The proposed function of the GPT in plastids of non-green tissues is the provision of Glc6P for starch biosynthesis and/or the oxidative pentose phosphate pathway.	Glucose-6-Phosphate	86-91	UDP-glcnac-adolichol phosphate glcnac-1-p-transferase	Arabidopsis thaliana	29-32
20382127-3	2010	Here, we found that formation of glucose-6-phosphate (G-6-P) is essential for glucose activation of ChREBP.	Glucose-6-Phosphate	33-52	MLX interacting protein like	Homo sapiens	100-106
20382127-3	2010	Here, we found that formation of glucose-6-phosphate (G-6-P) is essential for glucose activation of ChREBP.	Glucose-6-Phosphate	54-59	MLX interacting protein like	Homo sapiens	100-106
20382127-5	2010	Further metabolism of G-6-P through the two major glucose metabolic pathways, glycolysis and pentose-phosphate pathway, is not required for activation of ChREBP; over-expression of glucose-6-phosphate dehydrogenase (G6PD) diminishes, whereas RNAi knockdown of the enzyme enhances, the glucose response of GAL4-ChREBP, respectively.	Glucose-6-Phosphate	22-27	glucose-6-phosphate dehydrogenase	Homo sapiens	181-214
20382127-5	2010	Further metabolism of G-6-P through the two major glucose metabolic pathways, glycolysis and pentose-phosphate pathway, is not required for activation of ChREBP; over-expression of glucose-6-phosphate dehydrogenase (G6PD) diminishes, whereas RNAi knockdown of the enzyme enhances, the glucose response of GAL4-ChREBP, respectively.	Glucose-6-Phosphate	22-27	glucose-6-phosphate dehydrogenase	Homo sapiens	216-220
20382127-5	2010	Further metabolism of G-6-P through the two major glucose metabolic pathways, glycolysis and pentose-phosphate pathway, is not required for activation of ChREBP; over-expression of glucose-6-phosphate dehydrogenase (G6PD) diminishes, whereas RNAi knockdown of the enzyme enhances, the glucose response of GAL4-ChREBP, respectively.	Glucose-6-Phosphate	22-27	galectin 4	Homo sapiens	305-309
20382127-5	2010	Further metabolism of G-6-P through the two major glucose metabolic pathways, glycolysis and pentose-phosphate pathway, is not required for activation of ChREBP; over-expression of glucose-6-phosphate dehydrogenase (G6PD) diminishes, whereas RNAi knockdown of the enzyme enhances, the glucose response of GAL4-ChREBP, respectively.	Glucose-6-Phosphate	22-27	MLX interacting protein like	Homo sapiens	310-316
20412056-3	2010	Although hexokinase is well known to fulfil a crucial role in glucose sensing processes, a scenario is emerging in which the catalytic activity of mitochondria-associated hexokinase regulates glucose-6-phosphate and ROS levels, stimulating antioxidant defence mechanisms and the synthesis of phenolic compounds.	Glucose-6-Phosphate	192-211	hexokinase 1	Homo sapiens	9-19
20412056-3	2010	Although hexokinase is well known to fulfil a crucial role in glucose sensing processes, a scenario is emerging in which the catalytic activity of mitochondria-associated hexokinase regulates glucose-6-phosphate and ROS levels, stimulating antioxidant defence mechanisms and the synthesis of phenolic compounds.	Glucose-6-Phosphate	192-211	hexokinase 1	Homo sapiens	171-181
20641546-13	2004	The HKs, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in the transport of glucose into cells through the facilitative glucose transporters (GLUT1-13) (8).	Glucose-6-Phosphate	34-53	solute carrier family 2 member 1	Homo sapiens	190-195
20149676-4	2010	B 81 (2005) 26-32) it was shown that the conversion of glucose to glucose-6-phosphate by hexokinase in vitro was accelerated when ATP, which supplies the reaction with energy, was priorly irradiated at non-resonant optical frequencies (NROF, i.e., 655 and 830 nm).	Glucose-6-Phosphate	66-85	hexokinase 1	Homo sapiens	89-99
20208175-1	2010	Phosphoglucose isomerase (PGI) is a key enzyme in glycolysis and glycogenesis that catalyses the interconversion of glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	Glucose-6-Phosphate	116-135	glucose-6-phosphate isomerase	Homo sapiens	26-29
20208175-1	2010	Phosphoglucose isomerase (PGI) is a key enzyme in glycolysis and glycogenesis that catalyses the interconversion of glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P).	Glucose-6-Phosphate	137-140	glucose-6-phosphate isomerase	Homo sapiens	26-29
19804362-2	2010	H6PD converts glucose-6-phosphate and NADP(+) to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions of the pentose-phosphate pathway.	Glucose-6-Phosphate	14-33	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	0-4
19804362-2	2010	H6PD converts glucose-6-phosphate and NADP(+) to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions of the pentose-phosphate pathway.	Glucose-6-Phosphate	14-33	2,4-dienoyl-CoA reductase 1	Homo sapiens	72-77
19741523-2	2010	G6PT translocates glucose-6-phosphate (G6P) from the cytoplasm into the lumen of the endoplasmic reticulum, in which it is hydrolyzed to glucose either by a liver/kidney/intestine-restricted glucose-6-phosphatase-alpha (G6Pase-alpha) or by a ubiquitously expressed G6Pase-beta.	Glucose-6-Phosphate	18-37	solute carrier family 37 (glucose-6-phosphate transporter), member 4	Mus musculus	0-4
19741523-8	2010	SUMMARY: Neutrophil function is intimately linked to the regulation of glucose and G6P metabolism by the G6PT/G6Pase-beta complex.	Glucose-6-Phosphate	83-86	solute carrier family 37 (glucose-6-phosphate transporter), member 4	Mus musculus	105-109
19889875-8	2010	By contrast, the binding of two other maize AGPase allosteric activators (fructose-6-phosphate and glucose-6-phosphate) did not always mimic the changes observed for 3-PGA.	Glucose-6-Phosphate	99-118	glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic/amyloplastic	Zea mays	44-50
19939944-7	2010	A microarray analysis showed that transfer to high light resulted in a substantial but transient increase in expression of a gene, At1g61800, encoding a glucose-6-phosphate/phosphate translocator GPT2.	Glucose-6-Phosphate	153-172	glucose-6-phosphate/phosphate translocator 2	Arabidopsis thaliana	196-200
19755527-6	2009	RESULTS: Insulin reduced gluconeogenic flux to glucose-6-phosphate (G6P) but only at the near-maximal physiological level (16x basal).	Glucose-6-Phosphate	47-66	insulin	Canis lupus familiaris	9-16
19755527-6	2009	RESULTS: Insulin reduced gluconeogenic flux to glucose-6-phosphate (G6P) but only at the near-maximal physiological level (16x basal).	Glucose-6-Phosphate	68-71	insulin	Canis lupus familiaris	9-16
19520181-1	2009	Glucokinase is a member of the hexokinase family of enzymes that are responsible for the phosphorylation of glucose to glucose-6-phosphate for further utilization in cells.	Glucose-6-Phosphate	119-138	glucokinase	Homo sapiens	0-11
19548314-1	2009	Glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC) catalyzes the hydrolysis of glucose-6-phosphate to glucose and is a key enzyme in interprandial glucose homeostasis.	Glucose-6-Phosphate	79-98	glucose-6-phosphatase, catalytic	Mus musculus	45-49
19700406-1	2009	Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	50-69	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
19700406-1	2009	Glucose-6-phosphatase catalyzes the hydrolysis of glucose 6-phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	71-74	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
19641898-1	2009	AIMS/HYPOTHESIS: Glucokinase (GK), an enzyme that phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor that regulates insulin secretion in beta cells.	Glucose-6-Phosphate	81-100	glucokinase	Rattus norvegicus	17-28
19641898-1	2009	AIMS/HYPOTHESIS: Glucokinase (GK), an enzyme that phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor that regulates insulin secretion in beta cells.	Glucose-6-Phosphate	81-100	glucokinase	Rattus norvegicus	30-32
19608687-1	2009	BACKGROUND: Hexokinase is one of the key enzymes of glycolysis and catalyzes the phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	111-130	hexokinase 1	Homo sapiens	12-22
20641617-13	2004	The HKs, by converting glucose to glucose-6-phosphate, help maintain the downhill gradient that results in the transport of glucose into cells through the facilitative glucose transporters (GLUT1-13) (6).	Glucose-6-Phosphate	34-53	solute carrier family 2 member 1	Homo sapiens	190-195
19273580-9	2009	These phenomena are accompanied by a reduction in the expression of gluconeogenesis genes, such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphate (G6Pase).	Glucose-6-Phosphate	145-164	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	166-172
19228119-10	2009	Phosphorylation activated AtPPC1 at pH 7.3 by lowering its Km(PEP) and its sensitivity to inhibition by L-malate and L-aspartate, while enhancing activation by glucose 6-phosphate.	Glucose-6-Phosphate	160-179	phosphoenolpyruvate carboxylase 1	Arabidopsis thaliana	26-32
19176357-10	2009	After mice were fasted, the intrahepatic glucose-6-phosphate level was almost completely depleted in p85alpha-deficient mice.	Glucose-6-Phosphate	41-60	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	101-109
19204003-0	2009	An increased flux through the glucose 6-phosphate pool in enterocytes delays glucose absorption in Fxr-/- mice.	Glucose-6-Phosphate	30-49	nuclear receptor subfamily 1, group H, member 4	Mus musculus	99-102
19267278-5	2009	Insulin and exercise increase glycogen synthase affinity for glucose 6-phosphate and activity whereas high glycogen content and adrenaline decrease affinity for glucose 6-phosphate and activity.	Glucose-6-Phosphate	61-80	insulin	Homo sapiens	0-7
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	210-229	glucose-6-phosphate isomerase b	Danio rerio	0-29
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	210-229	glucose-6-phosphate isomerase b	Danio rerio	31-34
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	210-229	glucose-6-phosphate isomerase a	Danio rerio	57-81
19166981-1	2009	Glucose 6-phosphate isomerase (GPI), alternatively named phosphoglucose isomerase (PGI), autocrine motility factor (AMF) or neuroleukin (NLK), is a sugar metabolic enzyme catalyzing the interconversion between glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	210-229	glucose-6-phosphate isomerase a	Danio rerio	83-86
19004876-5	2009	The cDNA encoding TPS, which converts uridine-5"-diphosphoglucose and glucose-6-phosphate to trehalose-6-phosphate, was cloned from the fat body of H. armigera using rapid amplification of cDNA ends (RACE).	Glucose-6-Phosphate	70-89	Trehalose-6-phosphate synthase 1	Drosophila melanogaster	18-21
19267278-5	2009	Insulin and exercise increase glycogen synthase affinity for glucose 6-phosphate and activity whereas high glycogen content and adrenaline decrease affinity for glucose 6-phosphate and activity.	Glucose-6-Phosphate	161-180	insulin	Homo sapiens	0-7
19267278-6	2009	However, insulin, exercise and adrenaline also regulate intracellular concentration of glucose 6-phosphate which will influence in vivo glycogen synthase activity.	Glucose-6-Phosphate	87-106	insulin	Homo sapiens	9-16
18561188-0	2009	Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 A resolution.	Glucose-6-Phosphate	85-104	glucose-6-phosphate isomerase	Homo sapiens	21-45
19064002-1	2009	Glucose-6-phosphate isomerase (GPI), a homodimeric enzyme, catalyzes the interconversion between glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	97-116	glucose-6-phosphate isomerase	Homo sapiens	0-29
19064002-1	2009	Glucose-6-phosphate isomerase (GPI), a homodimeric enzyme, catalyzes the interconversion between glucose-6-phosphate and fructose-6-phosphate.	Glucose-6-Phosphate	97-116	glucose-6-phosphate isomerase	Homo sapiens	31-34
19052774-5	2009	A transketolase preparation from rehydrated leaves was able to synthesize the unusual C8 carbon sugar octulose when glucose-6-phosphate and hydroxy-pyruvate were used as acceptor and donor molecules in in vitro assays.	Glucose-6-Phosphate	116-135	transketolase	Homo sapiens	2-15
18847435-1	2009	The G6Pase (glucose-6-phosphatase catalytic subunit) catalyses the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate to glucose.	Glucose-6-Phosphate	146-165	glucose-6-phosphatase, catalytic	Mus musculus	4-10
22303248-3	2009	Firstly, trehalose-6-phosphate synthase (TPS) converts UDP-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P); secondly, T6P-phosphatase (TPP) converts T6P into trehalose and Pi.	Glucose-6-Phosphate	71-90	trehalose-6-phosphate synthase	Arabidopsis thaliana	9-39
22303248-3	2009	Firstly, trehalose-6-phosphate synthase (TPS) converts UDP-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P); secondly, T6P-phosphatase (TPP) converts T6P into trehalose and Pi.	Glucose-6-Phosphate	71-90	trehalose-6-phosphate synthase	Arabidopsis thaliana	41-44
22303248-3	2009	Firstly, trehalose-6-phosphate synthase (TPS) converts UDP-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P); secondly, T6P-phosphatase (TPP) converts T6P into trehalose and Pi.	Glucose-6-Phosphate	71-90	thylakoid processing peptide	Arabidopsis thaliana	133-148
22303248-3	2009	Firstly, trehalose-6-phosphate synthase (TPS) converts UDP-glucose and glucose-6-phosphate to trehalose-6-phosphate (T6P); secondly, T6P-phosphatase (TPP) converts T6P into trehalose and Pi.	Glucose-6-Phosphate	71-90	thylakoid processing peptide	Arabidopsis thaliana	150-153
19747136-2	2009	Glucokinase (GK) is a member of hexokinase family of enzymes that are responsible for the phosphorylation of glucose to glucose-6-phosphate for further utilization in cells.	Glucose-6-Phosphate	120-139	glucokinase	Homo sapiens	0-11
19747136-2	2009	Glucokinase (GK) is a member of hexokinase family of enzymes that are responsible for the phosphorylation of glucose to glucose-6-phosphate for further utilization in cells.	Glucose-6-Phosphate	120-139	glucokinase	Homo sapiens	13-15
18393672-6	2009	Benfotiamine was not shown to induce the glucose receptor Glut-2, however it was shown to activate glucokinase, the enzyme responsible for conversion of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	164-183	glucokinase	Rattus norvegicus	99-110
18717264-5	2008	The kinetic parameters (Kii and Kis) of the intact NE G-6-Pase for the phlorizin inhibition using glucose-6-phosphate (G-6-P) and M-6-P as substrates, were very similar.	Glucose-6-Phosphate	98-117	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	54-62
18927083-2	2008	In cell-free systems, Glc-1,6-P(2) is formed from 1,3-bisphosphoglycerate and Glc-6-P by two related enzymes: PGM2L1 (phosphoglucomutase 2-like 1) and, to a lesser extent, PGM2 (phosphoglucomutase 2).	Glucose-6-Phosphate	78-85	germ cell-less, spermatogenesis associated 1	Mus musculus	22-27
18927083-2	2008	In cell-free systems, Glc-1,6-P(2) is formed from 1,3-bisphosphoglycerate and Glc-6-P by two related enzymes: PGM2L1 (phosphoglucomutase 2-like 1) and, to a lesser extent, PGM2 (phosphoglucomutase 2).	Glucose-6-Phosphate	78-85	phosphoglucomutase 2 like 1	Homo sapiens	110-116
18927083-2	2008	In cell-free systems, Glc-1,6-P(2) is formed from 1,3-bisphosphoglycerate and Glc-6-P by two related enzymes: PGM2L1 (phosphoglucomutase 2-like 1) and, to a lesser extent, PGM2 (phosphoglucomutase 2).	Glucose-6-Phosphate	78-85	phosphoglucomutase 2 like 1	Homo sapiens	118-145
18927083-2	2008	In cell-free systems, Glc-1,6-P(2) is formed from 1,3-bisphosphoglycerate and Glc-6-P by two related enzymes: PGM2L1 (phosphoglucomutase 2-like 1) and, to a lesser extent, PGM2 (phosphoglucomutase 2).	Glucose-6-Phosphate	78-85	phosphoglucomutase 2	Homo sapiens	110-114
18927083-2	2008	In cell-free systems, Glc-1,6-P(2) is formed from 1,3-bisphosphoglycerate and Glc-6-P by two related enzymes: PGM2L1 (phosphoglucomutase 2-like 1) and, to a lesser extent, PGM2 (phosphoglucomutase 2).	Glucose-6-Phosphate	78-85	phosphoglucomutase 2	Homo sapiens	118-138
18651836-2	2008	It is regulated in part by the increase in blood-glucose concentration in the portal vein, which activates glucokinase, the first enzyme in the pathway, causing an increase in the concentration of glucose 6-P (glucose 6-phosphate), which modulates the phosphorylation state of downstream enzymes by acting synergistically with other allosteric effectors.	Glucose-6-Phosphate	197-208	glucokinase	Homo sapiens	107-118
18651836-2	2008	It is regulated in part by the increase in blood-glucose concentration in the portal vein, which activates glucokinase, the first enzyme in the pathway, causing an increase in the concentration of glucose 6-P (glucose 6-phosphate), which modulates the phosphorylation state of downstream enzymes by acting synergistically with other allosteric effectors.	Glucose-6-Phosphate	210-229	glucokinase	Homo sapiens	107-118
18651836-7	2008	The elevated glucose 6-P concentration, consequent to glucokinase activation, has a synergistic effect with glucose in promoting dephosphorylation (inactivation) of glycogen phosphorylase and inducing dephosphorylation (activation) of glycogen synthase.	Glucose-6-Phosphate	13-24	glucokinase	Homo sapiens	54-65
18260108-1	2008	Hexokinase is the first enzyme in the glycolytic pathway that catalyzes the transfer of a phosphoryl group from ATP to glucose to form glucose-6-phosphate and ADP.	Glucose-6-Phosphate	135-154	hexokinase	Saccharomyces cerevisiae S288C	0-10
18449899-1	2008	Glucose-6-phosphatase-alpha (G6PC) is a key enzyme in glucose homeostasis that catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the terminal step of gluconeogenesis and glycogenolysis.	Glucose-6-Phosphate	107-126	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-27
18449899-1	2008	Glucose-6-phosphatase-alpha (G6PC) is a key enzyme in glucose homeostasis that catalyzes the hydrolysis of glucose-6-phosphate to glucose and phosphate in the terminal step of gluconeogenesis and glycogenolysis.	Glucose-6-Phosphate	107-126	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	29-33
18763812-6	2008	Studies examining NADPH production and inhibitor studies for glucose-6-phosphate translocation across the endoplasmic reticulum (ER) membrane implicated hexose-6-phosphate dehydrogenase (H6PDH) in the metabolism of triadimefon as well.	Glucose-6-Phosphate	61-80	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	153-185
18763812-6	2008	Studies examining NADPH production and inhibitor studies for glucose-6-phosphate translocation across the endoplasmic reticulum (ER) membrane implicated hexose-6-phosphate dehydrogenase (H6PDH) in the metabolism of triadimefon as well.	Glucose-6-Phosphate	61-80	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	187-192
18611859-6	2008	Hepatic glucose 6-phosphate turnover was reduced in 9-h fasted Lxralpha(-/-) mice as compared with controls.	Glucose-6-Phosphate	8-27	nuclear receptor subfamily 1, group H, member 3	Mus musculus	63-71
20641222-5	2004	After glucose enters a living cell, phosphorylation catalyzed by hexokinase transforms the molecule to glucose-6-phosphate (G-6-P).	Glucose-6-Phosphate	103-122	hexokinase 1	Homo sapiens	65-75
17924400-1	2008	Hexokinase is the first enzyme in the glycolytic pathway and utilizes ATP to convert glucose to glucose-6-phosphate (G6P).	Glucose-6-Phosphate	96-115	hexokinase 1	Homo sapiens	0-10
17924400-1	2008	Hexokinase is the first enzyme in the glycolytic pathway and utilizes ATP to convert glucose to glucose-6-phosphate (G6P).	Glucose-6-Phosphate	117-120	hexokinase 1	Homo sapiens	0-10
18459129-7	2008	Remarkably, newly formed G6P was preferentially directed toward glycogen in MCAD(-/-) mice under both conditions.	Glucose-6-Phosphate	25-28	acyl-Coenzyme A dehydrogenase, medium chain	Mus musculus	76-80
20641222-5	2004	After glucose enters a living cell, phosphorylation catalyzed by hexokinase transforms the molecule to glucose-6-phosphate (G-6-P).	Glucose-6-Phosphate	124-129	hexokinase 1	Homo sapiens	65-75
18183605-1	2008	Exchange of hepatic glucose-6-phosphate (G6P) and glyceraldehyde-3-phosphate via transaldolase modifies hepatic G6P enrichment from glucose or gluconeogenic tracers.	Glucose-6-Phosphate	20-39	transaldolase 1	Homo sapiens	81-94
18064042-8	2008	This protection is prevented when HK-II is dissociated from mitochondria by incubation with glucose 6-phosphate or HK-II-dissociating peptide.	Glucose-6-Phosphate	92-111	hexokinase 2	Mus musculus	34-39
18183605-1	2008	Exchange of hepatic glucose-6-phosphate (G6P) and glyceraldehyde-3-phosphate via transaldolase modifies hepatic G6P enrichment from glucose or gluconeogenic tracers.	Glucose-6-Phosphate	41-44	transaldolase 1	Homo sapiens	81-94
17919760-6	2007	Deletion of malic enzyme gene, MAE1, did not show any significant phenotype when grown on glucose but a drastically increased branching from glucose 6-phosphate into the pentose phosphate pathway when grown on galactose.	Glucose-6-Phosphate	141-160	malate dehydrogenase (oxaloacetate-decarboxylating)	Saccharomyces cerevisiae S288C	31-35
18603618-2	2008	MIPS is an essential enzyme for production of inositol and inositol phosphates via its circularization of glucose-6-phosphate as the initial step.	Glucose-6-Phosphate	106-125	myo-inositol-1-phosphate synthase 1	Arabidopsis thaliana	0-4
18005663-0	2007	Glucose-6-phosphate as a probe for the glucosamine-6-phosphate N-acetyltransferase Michaelis complex.	Glucose-6-Phosphate	0-19	glucosamine-phosphate N-acetyltransferase 1	Homo sapiens	39-82
18005663-6	2007	Using the pseudo-substrate glucose-6-phosphate (Glc-6P) as a probe with GNA1 crystals, we have trapped the first GNAT (pseudo-)Michaelis complex, providing direct evidence for the nucleophilic attack of the substrate amine, and giving insight into the protonation of the thiolate leaving group.	Glucose-6-Phosphate	27-46	glucosamine-phosphate N-acetyltransferase 1	Homo sapiens	72-76
18005663-6	2007	Using the pseudo-substrate glucose-6-phosphate (Glc-6P) as a probe with GNA1 crystals, we have trapped the first GNAT (pseudo-)Michaelis complex, providing direct evidence for the nucleophilic attack of the substrate amine, and giving insight into the protonation of the thiolate leaving group.	Glucose-6-Phosphate	27-46	glycine-N-acyltransferase like 1	Homo sapiens	113-117
18005663-6	2007	Using the pseudo-substrate glucose-6-phosphate (Glc-6P) as a probe with GNA1 crystals, we have trapped the first GNAT (pseudo-)Michaelis complex, providing direct evidence for the nucleophilic attack of the substrate amine, and giving insight into the protonation of the thiolate leaving group.	Glucose-6-Phosphate	48-54	glucosamine-phosphate N-acetyltransferase 1	Homo sapiens	72-76
18005663-6	2007	Using the pseudo-substrate glucose-6-phosphate (Glc-6P) as a probe with GNA1 crystals, we have trapped the first GNAT (pseudo-)Michaelis complex, providing direct evidence for the nucleophilic attack of the substrate amine, and giving insight into the protonation of the thiolate leaving group.	Glucose-6-Phosphate	48-54	glycine-N-acyltransferase like 1	Homo sapiens	113-117
19812714-5	2007	The OPI1 gene product is a negative regulatory factor that controls the transcription of the INO1 structural gene, which encodes the enzyme catalyzing the limiting step in the biosynthesis of inositol, that is, the conversion of glucose-6-phosphate to inositol-3-phosphate.	Glucose-6-Phosphate	229-248	transcriptional regulator OPI1	Saccharomyces cerevisiae S288C	4-8
19812714-5	2007	The OPI1 gene product is a negative regulatory factor that controls the transcription of the INO1 structural gene, which encodes the enzyme catalyzing the limiting step in the biosynthesis of inositol, that is, the conversion of glucose-6-phosphate to inositol-3-phosphate.	Glucose-6-Phosphate	229-248	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	93-97
17588937-3	2007	G6Pase-alpha shares its substrate (glucose 6-phosphate; G6P) with hexose-6-phosphate-dehydrogenase (H6PDH), a microsomal enzyme that regenerates NADPH within the endoplasmic reticulum lumen, thereby conferring reductase activity upon 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).	Glucose-6-Phosphate	35-54	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-12
17949503-4	2007	RESULTS: In the present study, the sensitivity of HK-I toward release by G6P (2 mM) and a low concentration of KSCN (45 mM) was investigated using rat brain, bovine brain and human brain mitochondria.	Glucose-6-Phosphate	73-76	hexokinase 1	Rattus norvegicus	50-54
17949503-5	2007	Partial release from the G6P-insensitive site occurred without disruption of the mitochondrial membrane as a whole and as related to HK-I binding to the G6P-sensitive site.	Glucose-6-Phosphate	25-28	hexokinase 1	Homo sapiens	133-137
17956314-1	2007	GK (glucokinase) catalyses the phosphorylation of glucose to glucose 6-phosphate in glucosensitive cells.	Glucose-6-Phosphate	61-80	glucokinase	Homo sapiens	4-15
17588937-3	2007	G6Pase-alpha shares its substrate (glucose 6-phosphate; G6P) with hexose-6-phosphate-dehydrogenase (H6PDH), a microsomal enzyme that regenerates NADPH within the endoplasmic reticulum lumen, thereby conferring reductase activity upon 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).	Glucose-6-Phosphate	35-54	RNA, U1 small nuclear 1	Homo sapiens	234-289
17533217-7	2007	The K(m) value of G6PD for glucose-6-phosphate was two times higher than the K(m) value of PGD for phosphogluconate.	Glucose-6-Phosphate	27-46	glucose-6-phosphate dehydrogenase	Rattus norvegicus	18-22
17533217-7	2007	The K(m) value of G6PD for glucose-6-phosphate was two times higher than the K(m) value of PGD for phosphogluconate.	Glucose-6-Phosphate	27-46	phosphogluconate dehydrogenase	Rattus norvegicus	91-94
17553851-9	2007	Glucokinase had a high control on glucose-6-phosphate content; however, like PFK2, it had a relative modest effect on the fructose-2,6-P(2) content.	Glucose-6-Phosphate	34-53	glucokinase	Rattus norvegicus	0-11
17376479-3	2007	However, fine regulation of CCR is accomplished by the small molecule effectors, glucose 6-phosphate (G6P) and fructose 1,6-bisphosphate (FBP), which somehow enhance CcpA-(HPr-Ser46-P) binding to DNA.	Glucose-6-Phosphate	81-100	haptoglobin-related protein	Homo sapiens	172-175
17137780-0	2007	Development of a glucose-6-phosphate biosensor based on coimmobilized p-hydroxybenzoate hydroxylase and glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	17-36	glucose-6-phosphate dehydrogenase	Homo sapiens	104-137
17137780-1	2007	This work reports the development of an amperometric glucose-6-phosphate biosensor by coimmobilizing p-hydroxybenzoate hydroxylase (HBH) and glucose-6-phosphate dehydrogenase (G6PDH) on a screen-printed electrode.	Glucose-6-Phosphate	53-72	glucose-6-phosphate dehydrogenase	Homo sapiens	141-174
17137780-1	2007	This work reports the development of an amperometric glucose-6-phosphate biosensor by coimmobilizing p-hydroxybenzoate hydroxylase (HBH) and glucose-6-phosphate dehydrogenase (G6PDH) on a screen-printed electrode.	Glucose-6-Phosphate	53-72	glucose-6-phosphate dehydrogenase	Homo sapiens	176-181
17137780-2	2007	The principle of the determination scheme is as follows: G6PDH catalyzes the specific dehydrogenation of glucose-6-phosphate by consuming NADP(+).	Glucose-6-Phosphate	105-124	glucose-6-phosphate dehydrogenase	Homo sapiens	57-62
17376479-3	2007	However, fine regulation of CCR is accomplished by the small molecule effectors, glucose 6-phosphate (G6P) and fructose 1,6-bisphosphate (FBP), which somehow enhance CcpA-(HPr-Ser46-P) binding to DNA.	Glucose-6-Phosphate	102-105	haptoglobin-related protein	Homo sapiens	172-175
17430128-2	2007	The complex consists of a glucose-6-phosphate transporter (G6PT) that translocates glucose-6-phosphate from the cytoplasm into the lumen of the endoplasmic reticulum, and a G6Pase-alpha catalytic unit that hydrolyses the glucose-6-phosphate into glucose and phosphate.	Glucose-6-Phosphate	26-45	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	59-63
17289676-5	2007	The models predicted that the allostery-dependent Hb interaction with BIII accelerates consumption of upstream glycolytic substrates such as glucose 6-phosphate and increases downstream products such as phosphoenolpyruvate.	Glucose-6-Phosphate	141-160	calcium voltage-gated channel subunit alpha1 B	Homo sapiens	70-74
17430128-2	2007	The complex consists of a glucose-6-phosphate transporter (G6PT) that translocates glucose-6-phosphate from the cytoplasm into the lumen of the endoplasmic reticulum, and a G6Pase-alpha catalytic unit that hydrolyses the glucose-6-phosphate into glucose and phosphate.	Glucose-6-Phosphate	26-45	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	173-185
17430128-2	2007	The complex consists of a glucose-6-phosphate transporter (G6PT) that translocates glucose-6-phosphate from the cytoplasm into the lumen of the endoplasmic reticulum, and a G6Pase-alpha catalytic unit that hydrolyses the glucose-6-phosphate into glucose and phosphate.	Glucose-6-Phosphate	83-102	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	26-57
17430128-2	2007	The complex consists of a glucose-6-phosphate transporter (G6PT) that translocates glucose-6-phosphate from the cytoplasm into the lumen of the endoplasmic reticulum, and a G6Pase-alpha catalytic unit that hydrolyses the glucose-6-phosphate into glucose and phosphate.	Glucose-6-Phosphate	83-102	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	59-63
17430128-2	2007	The complex consists of a glucose-6-phosphate transporter (G6PT) that translocates glucose-6-phosphate from the cytoplasm into the lumen of the endoplasmic reticulum, and a G6Pase-alpha catalytic unit that hydrolyses the glucose-6-phosphate into glucose and phosphate.	Glucose-6-Phosphate	83-102	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	173-185
17085448-8	2007	Hence, the contact of HPrHis-15 to Asp-297 in CcpA is a determinant for HPr specific FBP and Glc-6-P stimulation.	Glucose-6-Phosphate	93-100	haptoglobin-related protein	Homo sapiens	22-25
17126561-1	2007	Phosphoglucose isomerase (PGI) EC 5.3.1.9, is a housekeeping enzyme that catalyzes the reversible isomerization of d-glucopyranose-6-phosphate and d-fructofuranose-6-phosphate.	Glucose-6-Phosphate	115-142	glucose-6-phosphate isomerase	Mycobacterium tuberculosis H37Rv	0-24
17126561-1	2007	Phosphoglucose isomerase (PGI) EC 5.3.1.9, is a housekeeping enzyme that catalyzes the reversible isomerization of d-glucopyranose-6-phosphate and d-fructofuranose-6-phosphate.	Glucose-6-Phosphate	115-142	glucose-6-phosphate isomerase	Mycobacterium tuberculosis H37Rv	26-29
17318259-3	2007	Recently, we characterized a second G6Pase activity, that of G6Pase-beta (also known as G6PC), which is also capable of hydrolyzing G6P to glucose but is ubiquitously expressed and not implicated in interprandial blood glucose homeostasis.	Glucose-6-Phosphate	36-39	glucose-6-phosphatase, catalytic	Mus musculus	88-92
17217471-6	2007	Histidine-tagged Arabidopsis PMM (AtPMM) purified from Escherichia coli converted mannose-1-phosphate into mannose-6-phosphate and glucose-1-phosphate into glucose-6-phosphate, with the former reaction being more efficient than the latter one.	Glucose-6-Phosphate	156-175	phosphomannomutase	Arabidopsis thaliana	29-32
17229727-1	2007	Hexokinase catalyzes the phosphorylation of glucose to glucose 6-phosphate by using ATP as a phosphoryl donor.	Glucose-6-Phosphate	55-74	hexokinase 1	Homo sapiens	0-10
17106062-1	2007	Glucose homeostasis requires the proper expression and regulation of the catalytic subunit of glucose-6-phosphatase (G-6-Pase), which hydrolyzes glucose 6-phosphate to glucose in glucose-producing tissues.	Glucose-6-Phosphate	145-164	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	94-115
17106062-1	2007	Glucose homeostasis requires the proper expression and regulation of the catalytic subunit of glucose-6-phosphatase (G-6-Pase), which hydrolyzes glucose 6-phosphate to glucose in glucose-producing tissues.	Glucose-6-Phosphate	145-164	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	117-125
17085448-3	2007	In addition, the glycolytic intermediates fructose 1,6-bisphosphate (FBP) and glucose 6-phosphate (Glc-6-P) stimulate HPr-Ser46-P but not Crh-Ser46-P binding to CcpA.	Glucose-6-Phosphate	78-97	haptoglobin-related protein	Homo sapiens	118-121
17085448-3	2007	In addition, the glycolytic intermediates fructose 1,6-bisphosphate (FBP) and glucose 6-phosphate (Glc-6-P) stimulate HPr-Ser46-P but not Crh-Ser46-P binding to CcpA.	Glucose-6-Phosphate	99-106	haptoglobin-related protein	Homo sapiens	118-121
17187055-6	2007	d-Glucose and d-glucose-6-phosphate are direct agonists of both LXR-alpha and LXR-beta.	Glucose-6-Phosphate	14-35	nuclear receptor subfamily 1, group H, member 3	Mus musculus	64-73
17049721-4	2007	The rate of glucose-6-phosphate formation, however, was decreased by resistin both in the absence and presence of insulin; in the absence of insulin, resistin decreased glucose-6-phosphate formation by reducing hexokinase type I activity without affecting glucose uptake; by contrast, in the presence of insulin, resistin decreased glucose-6-phosphate formation by reducing the Vmax of glucose uptake without changing hexokinase type I activity.	Glucose-6-Phosphate	12-31	insulin	Homo sapiens	114-121
17049721-4	2007	The rate of glucose-6-phosphate formation, however, was decreased by resistin both in the absence and presence of insulin; in the absence of insulin, resistin decreased glucose-6-phosphate formation by reducing hexokinase type I activity without affecting glucose uptake; by contrast, in the presence of insulin, resistin decreased glucose-6-phosphate formation by reducing the Vmax of glucose uptake without changing hexokinase type I activity.	Glucose-6-Phosphate	169-188	hexokinase 1	Homo sapiens	211-228
17049721-4	2007	The rate of glucose-6-phosphate formation, however, was decreased by resistin both in the absence and presence of insulin; in the absence of insulin, resistin decreased glucose-6-phosphate formation by reducing hexokinase type I activity without affecting glucose uptake; by contrast, in the presence of insulin, resistin decreased glucose-6-phosphate formation by reducing the Vmax of glucose uptake without changing hexokinase type I activity.	Glucose-6-Phosphate	169-188	hexokinase 1	Homo sapiens	211-228
17187055-6	2007	d-Glucose and d-glucose-6-phosphate are direct agonists of both LXR-alpha and LXR-beta.	Glucose-6-Phosphate	14-35	nuclear receptor subfamily 1, group H, member 2	Mus musculus	78-86
19669468-6	2006	The paper describes the glucose sensing mechanism via the complex dynamics of the key enzyme glucokinase, which controls the first step in glucose metabolism: phosphorylation of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	189-208	glucokinase	Homo sapiens	93-104
17220512-3	2007	To support the operation of the OPPP there is a need for glucose 6-phosphate (Glc6P) to be imported into the plastids by the glucose phosphate translocator (GPT).	Glucose-6-Phosphate	57-76	glutamic--pyruvic transaminase	Homo sapiens	125-155
17220512-3	2007	To support the operation of the OPPP there is a need for glucose 6-phosphate (Glc6P) to be imported into the plastids by the glucose phosphate translocator (GPT).	Glucose-6-Phosphate	57-76	glutamic--pyruvic transaminase	Homo sapiens	157-160
17220512-3	2007	To support the operation of the OPPP there is a need for glucose 6-phosphate (Glc6P) to be imported into the plastids by the glucose phosphate translocator (GPT).	Glucose-6-Phosphate	78-83	glutamic--pyruvic transaminase	Homo sapiens	125-155
17220512-3	2007	To support the operation of the OPPP there is a need for glucose 6-phosphate (Glc6P) to be imported into the plastids by the glucose phosphate translocator (GPT).	Glucose-6-Phosphate	78-83	glutamic--pyruvic transaminase	Homo sapiens	157-160
17982275-10	2007	Silibinin inhibits glucose-6-phosphatase in rat liver microsomes in a concentration-dependent manner that could explain the decrease in glucose-6-phosphate hydrolysis seen in intact cells.	Glucose-6-Phosphate	136-155	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	19-40
17023421-1	2006	In liver, glucose-6-phosphatase catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate, the final step in the gluconeogenic and glycogenolytic pathways.	Glucose-6-Phosphate	60-79	glucose-6-phosphatase, catalytic	Mus musculus	10-31
17023421-1	2006	In liver, glucose-6-phosphatase catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate, the final step in the gluconeogenic and glycogenolytic pathways.	Glucose-6-Phosphate	81-84	glucose-6-phosphatase, catalytic	Mus musculus	10-31
16670083-8	2006	MDP-1 dephosphorylated up to approximately 75% of the fructosamine 6-phosphates that are present on lysozyme after incubation of this protein with Glu-6-P.	Glucose-6-Phosphate	147-154	magnesium dependent phosphatase 1	Homo sapiens	0-5
16892090-5	2006	The abundant amounts of HK II bind both the ATP and the incoming glucose producing the product glucose-6-phosphate, also at an elevated rate.	Glucose-6-Phosphate	95-114	hexokinase 2	Homo sapiens	24-29
16670083-9	2006	Furthermore, lysozyme glycated with Glu-6-P was converted by MDP-1 to a substrate for FN3K.	Glucose-6-Phosphate	36-43	magnesium dependent phosphatase 1	Homo sapiens	61-66
16670083-9	2006	Furthermore, lysozyme glycated with Glu-6-P was converted by MDP-1 to a substrate for FN3K.	Glucose-6-Phosphate	36-43	fructosamine 3 kinase	Homo sapiens	86-90
16670083-10	2006	We conclude that MDP-1 may act physiologically in conjunction with FN3K to free proteins from the glycation products derived from Glu-6-P.	Glucose-6-Phosphate	130-137	magnesium dependent phosphatase 1	Homo sapiens	17-22
16670083-10	2006	We conclude that MDP-1 may act physiologically in conjunction with FN3K to free proteins from the glycation products derived from Glu-6-P.	Glucose-6-Phosphate	130-137	fructosamine 3 kinase	Homo sapiens	67-71
16640561-9	2006	On the other hand, hexokinase activity was strongly inhibited by high, but physiological, concentrations of Glc6P.	Glucose-6-Phosphate	108-113	hexokinase 1	Homo sapiens	19-29
16636060-4	2006	AglB is an unusual NAD+/Mn2+-dependent phospho-alpha-glucosidase that promotes growth of MG-1655 (pAP1) by catalyzing the in vivo hydrolysis of methyl-alpha-D-glucopyranoside 6-phosphate to yield glucose 6-phosphate and methanol.	Glucose-6-Phosphate	196-215	glycoside hydrolase	Escherichia coli str. K-12 substr. MG1655	47-64
16395584-2	2006	In plants, the myo-inositol-1-phosphate is synthesized from glucose 6-phosphate in a reaction catalyzed by the enzyme myo-inositol-1-phosphate synthase (EC 5.5.1.4).	Glucose-6-Phosphate	60-79	myo-inositol-3-phosphate synthase	Glycine max	118-151
16640561-10	2006	Therefore, the enhanced glycolytic flux in fast-growth tumor cells was still controlled by an over-produced, but Glc6P-inhibited hexokinase.	Glucose-6-Phosphate	113-118	hexokinase 1	Homo sapiens	129-139
16307870-7	2006	We propose that glucose metabolism leads to glucose-6-phosphate-dependent unbinding of glucokinase, relief of VDAC inhibition, release of ATP from mitochondria and ATP-dependent insulin release.	Glucose-6-Phosphate	44-63	glucokinase	Rattus norvegicus	87-98
16789437-4	2006	In this study G-6-PD from lamb kidney cortex was competitively inhibited by zinc both with respect to glucose-6-phosphate (G-6-P) and NADP+ with Ki values of 1.066 +/- 0.106 and 0.111 +/- 0.007 mM respectively whereas cadmium was a non-competitive inhibitor with respect to both G-6-P and NADP+ Ki values of 2.028 +/- 0.175 and 2.044 +/- 0.289 mM respectively.	Glucose-6-Phosphate	102-121	glucose-6-phosphate dehydrogenase	Homo sapiens	14-20
16789437-4	2006	In this study G-6-PD from lamb kidney cortex was competitively inhibited by zinc both with respect to glucose-6-phosphate (G-6-P) and NADP+ with Ki values of 1.066 +/- 0.106 and 0.111 +/- 0.007 mM respectively whereas cadmium was a non-competitive inhibitor with respect to both G-6-P and NADP+ Ki values of 2.028 +/- 0.175 and 2.044 +/- 0.289 mM respectively.	Glucose-6-Phosphate	123-128	glucose-6-phosphate dehydrogenase	Homo sapiens	14-20
16757173-3	2006	The 69 kDa AtUSP gene product exhibited high activity with Glc-1-P, GlcA-1-P and Gal-1-P, but low activity with GlcNAc-1-P, Fuc-1-P, Man-1-P, inositol-1-P or Glc-6-P.	Glucose-6-Phosphate	158-165	UDP-sugar pyrophosphorylase	Arabidopsis thaliana	11-16
16234247-10	2006	Using isolated intact liver or fat microsomes, glucose-6 phosphate stimulated 11 beta-HSD1 oxo-reductase, and this effect was blocked by selective inhibitors of glucose-6-phosphate transport.	Glucose-6-Phosphate	47-66	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	78-90
16234247-10	2006	Using isolated intact liver or fat microsomes, glucose-6 phosphate stimulated 11 beta-HSD1 oxo-reductase, and this effect was blocked by selective inhibitors of glucose-6-phosphate transport.	Glucose-6-Phosphate	161-180	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	78-90
16403021-8	2006	The high control strength of glucokinase on glycogenic flux is explained by its concentration control coefficient on Glc6P and the high control strength of Glc6P on glycogen synthesis.	Glucose-6-Phosphate	117-122	glucokinase	Homo sapiens	29-40
16403021-8	2006	The high control strength of glucokinase on glycogenic flux is explained by its concentration control coefficient on Glc6P and the high control strength of Glc6P on glycogen synthesis.	Glucose-6-Phosphate	156-161	glucokinase	Homo sapiens	29-40
16403021-9	2006	It is suggested that the regulatory strength of pharmacological glucokinase activators on glycogen metabolism can be predicted from their effect on the Glc6P content.	Glucose-6-Phosphate	152-157	glucokinase	Homo sapiens	64-75
16477532-1	2006	The glucose-6-phosphatase (G6Pase) system participates in the regulation of glucose homeostasis by converting glucose-6-phosphate (G6P) into glucose and inorganic phosphates.	Glucose-6-Phosphate	110-129	glucose-6-phosphatase, catalytic	Mus musculus	4-25
16477532-1	2006	The glucose-6-phosphatase (G6Pase) system participates in the regulation of glucose homeostasis by converting glucose-6-phosphate (G6P) into glucose and inorganic phosphates.	Glucose-6-Phosphate	110-129	glucose-6-phosphatase, catalytic	Mus musculus	27-33
16477532-1	2006	The glucose-6-phosphatase (G6Pase) system participates in the regulation of glucose homeostasis by converting glucose-6-phosphate (G6P) into glucose and inorganic phosphates.	Glucose-6-Phosphate	27-30	glucose-6-phosphatase, catalytic	Mus musculus	4-25
16330444-1	2005	Molecular screening for glucose-6-phosphate (G6PD) mutations in two Jordanian populations revealed six different mutations and higher incidences of G6PD deficiency and G6PD A- (376A-->G + 202G-->A) mutation in Jordan Valley than in the Amman area.	Glucose-6-Phosphate	24-43	glucose-6-phosphate dehydrogenase	Homo sapiens	45-49
16330444-1	2005	Molecular screening for glucose-6-phosphate (G6PD) mutations in two Jordanian populations revealed six different mutations and higher incidences of G6PD deficiency and G6PD A- (376A-->G + 202G-->A) mutation in Jordan Valley than in the Amman area.	Glucose-6-Phosphate	24-43	glucose-6-phosphate dehydrogenase	Homo sapiens	148-152
16166083-2	2005	In addition to potent inhibition, glucose 6-phosphate releases HKI from the outer leaflet of mitochondria; however, the site of glucose 6-phosphate association responsible for the release of HKI is unclear.	Glucose-6-Phosphate	128-147	hexokinase 1	Homo sapiens	191-194
16166083-5	2005	Release of wild-type and mutant hexokinases from mitochondria by glucose 6-phosphate follow equilibrium models, which explain the release phenomenon as the repartitioning of ligand-bound HKI between solution and the membrane.	Glucose-6-Phosphate	65-84	hexokinase 1	Homo sapiens	187-190
16166083-6	2005	Mutations that block the binding of glucose 6-phosphate to the C-terminal half of HKI have little or no effect on the glucose 6-phosphate release.	Glucose-6-Phosphate	36-55	hexokinase 1	Homo sapiens	82-85
16166083-7	2005	In contrast, mutations that block glucose 6-phosphate binding to the N-terminal half require approximately 7-fold higher concentrations of glucose 6-phosphate for the release of HKI.	Glucose-6-Phosphate	34-53	hexokinase 1	Homo sapiens	178-181
16166083-7	2005	In contrast, mutations that block glucose 6-phosphate binding to the N-terminal half require approximately 7-fold higher concentrations of glucose 6-phosphate for the release of HKI.	Glucose-6-Phosphate	139-158	hexokinase 1	Homo sapiens	178-181
16166083-8	2005	Results here implicate a primary role for the glucose 6-phosphate binding site at the N-terminal half of HKI in the release mechanism.	Glucose-6-Phosphate	46-65	hexokinase 1	Homo sapiens	105-108
16358787-5	2005	As a result, atoms C-3 and C-4 of glucose become enriched with the heavy isotope, and subsequent mixing of atoms and the specificity of interactions in the photorespiration chain lead to an isotope weighting of the other atoms and an uneven distribution of carbon isotopes in glucose-6-phosphate and other photorespiration products.	Glucose-6-Phosphate	276-295	complement C3	Homo sapiens	19-22
16358787-5	2005	As a result, atoms C-3 and C-4 of glucose become enriched with the heavy isotope, and subsequent mixing of atoms and the specificity of interactions in the photorespiration chain lead to an isotope weighting of the other atoms and an uneven distribution of carbon isotopes in glucose-6-phosphate and other photorespiration products.	Glucose-6-Phosphate	276-295	complement C4A (Rodgers blood group)	Homo sapiens	27-30
16787225-1	2006	Glucokinase (GK) is a molecular sensor that regulates glucose induced insulin secretion in pancreatic beta-cells and glucose homeostasis in the liver via catalysis of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	178-197	glucokinase	Homo sapiens	0-11
16787225-1	2006	Glucokinase (GK) is a molecular sensor that regulates glucose induced insulin secretion in pancreatic beta-cells and glucose homeostasis in the liver via catalysis of glucose to glucose-6-phosphate.	Glucose-6-Phosphate	178-197	glucokinase	Homo sapiens	13-15
16403021-0	2006	The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism.	Glucose-6-Phosphate	12-31	glucokinase	Homo sapiens	60-71
17121275-1	2006	The first and rate-limiting step in the biosynthesis of myo-inositol is the conversion of D-glucose 6-phosphate to 1L-myo-inositol 1-phosphate catalyzed by 1L-myo-inositol 1-phosphate synthase (MIP synthase).	Glucose-6-Phosphate	90-111	inositol-3-phosphate synthase 1	Homo sapiens	194-206
16166083-1	2005	One molecule of glucose 6-phosphate inhibits brain hexokinase (HKI) with high affinity by binding to either one of two sites located in distinct halves of the enzyme.	Glucose-6-Phosphate	16-35	hexokinase 1	Homo sapiens	63-66
16166083-2	2005	In addition to potent inhibition, glucose 6-phosphate releases HKI from the outer leaflet of mitochondria; however, the site of glucose 6-phosphate association responsible for the release of HKI is unclear.	Glucose-6-Phosphate	34-53	hexokinase 1	Homo sapiens	63-66
16269670-7	2005	This conclusion was supported by measurements of sugar phosphates, which showed that there were increased concentrations of glucose-6-phosphate, galactose-6-phosphate, and fructose-6-phosphate in the strain construct overexpressing PGM2.	Glucose-6-Phosphate	124-143	phosphoglucomutase PGM2	Saccharomyces cerevisiae S288C	232-236
15906092-3	2005	Molecular analysis of the glucose 6-phosphate translocase (G6PT1) gene was performed in all patients.	Glucose-6-Phosphate	26-45	solute carrier family 37 member 4	Homo sapiens	59-64
15752725-3	2005	C-3 epimerization activity was detected using a NADPH-generating system containing glucose-6-phosphate, NADP, glucose-6-phosphate dehydrogenase, and Mg(2+).	Glucose-6-Phosphate	83-102	complement C3	Homo sapiens	0-3
15767253-1	2005	Glucose-6-phosphatase (G6Pase) catalyzes the release of glucose from glucose 6-phosphate.	Glucose-6-Phosphate	69-88	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
15767253-1	2005	Glucose-6-phosphatase (G6Pase) catalyzes the release of glucose from glucose 6-phosphate.	Glucose-6-Phosphate	69-88	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	23-29
15858258-0	2005	Structural studies of glucose-6-phosphate and NADP+ binding to human glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	22-41	glucose-6-phosphate dehydrogenase	Homo sapiens	69-102
16092052-7	2005	We further suggest that TALase"s retrograde motion contributes to uncoupling the shunt from its source of glucose-6-phosphate at the plasma membrane, thereby blunting nicotinamide adenine dinucleotide phosphate (reduced form) production and downstream oxidant production by neutrophils.	Glucose-6-Phosphate	106-125	transaldolase 1	Homo sapiens	24-30
16161025-2	2005	QGR increased the G-6-Pase K(m) for glucose-6-phosphate without change in the V(max).	Glucose-6-Phosphate	36-55	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	18-26
15689508-0	2005	The crystal structure of rabbit phosphoglucose isomerase complexed with D-sorbitol-6-phosphate, an analog of the open chain form of D-glucose-6-phosphate.	Glucose-6-Phosphate	132-153	glucose-6-phosphate isomerase	Oryctolagus cuniculus	32-56
15793230-3	2005	Increased GLUT2 protein content, glucokinase mRNA, and glucose-6-phosphate in GLUT4 null mice may provide substrate for the enhanced fatty acid synthesis.	Glucose-6-Phosphate	55-74	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	78-83
15722468-1	2005	Plastids of nongreen tissues can import carbon in the form of glucose 6-phosphate via the glucose 6-phosphate/phosphate translocator (GPT).	Glucose-6-Phosphate	62-81	UDP-glcnac-adolichol phosphate glcnac-1-p-transferase	Arabidopsis thaliana	90-132
15722468-1	2005	Plastids of nongreen tissues can import carbon in the form of glucose 6-phosphate via the glucose 6-phosphate/phosphate translocator (GPT).	Glucose-6-Phosphate	62-81	UDP-glcnac-adolichol phosphate glcnac-1-p-transferase	Arabidopsis thaliana	134-137
15722468-3	2005	Both proteins show glucose 6-phosphate translocator activity after reconstitution in liposomes, and each of them can rescue the low-starch leaf phenotype of the pgi1 mutant (which lacks plastid phosphoglucoisomerase), indicating that the two proteins are also functional in planta.	Glucose-6-Phosphate	19-38	phosphoglucose isomerase 1	Arabidopsis thaliana	161-165
15722468-9	2005	Taken together, our results indicate that GPT1-mediated import of glucose 6-phosphate into nongreen plastids is crucial for gametophyte development.	Glucose-6-Phosphate	66-85	glucose 6-phosphate/phosphate translocator 1	Arabidopsis thaliana	42-46
15661744-4	2005	Recently, we reported a ubiquitously expressed Glc-6-P hydrolase, glucose-6-phosphatase-beta (Glc-6-Pase-beta), that can couple with the Glc-6-P transporter to hydrolyze Glc-6-P to glucose in the terminal stages of glycogenolysis and gluconeogenesis.	Glucose-6-Phosphate	47-54	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	66-87
15665330-3	2005	Previous x-ray crystallographic analysis of Zea mays PEPC has revealed a binding site for sulfate ion, speculated to be the site for an allosteric activator, glucose 6-phosphate (Glc-6-P) (Matsumura, H., Xie, Y., Shirakata, S., Inoue, T., Yoshinaga, T., Ueno, Y., Izui, K., and Kai, Y.	Glucose-6-Phosphate	158-177	phosphoenolpyruvate carboxylase 1	Zea mays	53-57
15665330-3	2005	Previous x-ray crystallographic analysis of Zea mays PEPC has revealed a binding site for sulfate ion, speculated to be the site for an allosteric activator, glucose 6-phosphate (Glc-6-P) (Matsumura, H., Xie, Y., Shirakata, S., Inoue, T., Yoshinaga, T., Ueno, Y., Izui, K., and Kai, Y.	Glucose-6-Phosphate	179-186	phosphoenolpyruvate carboxylase 1	Zea mays	53-57
15689508-1	2005	Phosphoglucose isomerase (PGI) catalyzes the isomerization of D-glucose-6-phosphate (G6P) and D-fructose-6-phosphate (F6P) in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	62-83	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
15689508-1	2005	Phosphoglucose isomerase (PGI) catalyzes the isomerization of D-glucose-6-phosphate (G6P) and D-fructose-6-phosphate (F6P) in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	62-83	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
15689508-1	2005	Phosphoglucose isomerase (PGI) catalyzes the isomerization of D-glucose-6-phosphate (G6P) and D-fructose-6-phosphate (F6P) in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	85-88	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
15689508-1	2005	Phosphoglucose isomerase (PGI) catalyzes the isomerization of D-glucose-6-phosphate (G6P) and D-fructose-6-phosphate (F6P) in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	85-88	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
15464731-2	2004	5.5.1.4), encoded by ISYNA1, catalyzes the de novo synthesis of inositol 1-phosphate from glucose 6-phosphate.	Glucose-6-Phosphate	90-109	inositol-3-phosphate synthase 1	Homo sapiens	21-27
15667334-1	2005	The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor of insulin-producing beta-cells.	Glucose-6-Phosphate	66-85	glucokinase	Homo sapiens	11-13
15667334-1	2005	The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor of insulin-producing beta-cells.	Glucose-6-Phosphate	66-85	glucokinase	Homo sapiens	15-26
15667334-1	2005	The enzyme GK (glucokinase), which phosphorylates glucose to form glucose 6-phosphate, serves as the glucose sensor of insulin-producing beta-cells.	Glucose-6-Phosphate	66-85	insulin	Homo sapiens	119-126
16492548-8	2005	Amylin-induced glycogenolysis resulted in intramuscular accumulation of glucose-6-phosphate and release of lactate from tissue beds that included muscle.	Glucose-6-Phosphate	72-91	islet amyloid polypeptide	Rattus norvegicus	0-6
20641537-8	2004	The HKs, by converting glucose to glucose-6-phosphate, help to maintain the downhill gradient that results in the transport of glucose into cells through the facilitative glucose transporters (GLUT1-13) (3).	Glucose-6-Phosphate	34-53	solute carrier family 2 member 1	Homo sapiens	193-198
15724432-7	2005	When characterised for its kinetic and regulatory properties, it displayed the same affinity for glucose and MgATP as the human hexokinase type I and was inhibited by glucose 6-phosphate competitively versus MgATP.	Glucose-6-Phosphate	167-186	hexokinase 1	Homo sapiens	128-145
15193269-5	2004	Northern blots showed that refeeding after a prolonged starvation rapidly reverses the glucose/glucose-6-phosphate substrate cycle flux in the fish liver through decreased G6Pase expression and strong glucokinase (GK) induction.	Glucose-6-Phosphate	95-114	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	172-178
15299033-2	2004	The best known and most widely distributed pathway of trehalose synthesis involves the transfer of glucose from UDP-glucose to glucose 6-phosphate to form trehalose-6-phosphate and UDP via the trehalose-6-phosphate synthase (TPS1).	Glucose-6-Phosphate	127-146	tryptase alpha/beta 1	Homo sapiens	225-229
15087461-2	2004	In the final steps of glycogenolysis, intracellular glucose 6-phosphate (Glc-6-P) is transported into the endoplasmic reticulum where it is hydrolyzed to glucose by glucose-6-phosphatase (Glc-6-Pase).	Glucose-6-Phosphate	52-71	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	165-186
15087461-2	2004	In the final steps of glycogenolysis, intracellular glucose 6-phosphate (Glc-6-P) is transported into the endoplasmic reticulum where it is hydrolyzed to glucose by glucose-6-phosphatase (Glc-6-Pase).	Glucose-6-Phosphate	52-71	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	188-198
15087461-2	2004	In the final steps of glycogenolysis, intracellular glucose 6-phosphate (Glc-6-P) is transported into the endoplasmic reticulum where it is hydrolyzed to glucose by glucose-6-phosphatase (Glc-6-Pase).	Glucose-6-Phosphate	73-80	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	165-186
15087461-2	2004	In the final steps of glycogenolysis, intracellular glucose 6-phosphate (Glc-6-P) is transported into the endoplasmic reticulum where it is hydrolyzed to glucose by glucose-6-phosphatase (Glc-6-Pase).	Glucose-6-Phosphate	73-80	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	188-198
15342241-0	2004	The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening.	Glucose-6-Phosphate	96-115	glucose-6-phosphate isomerase 1	Mus musculus	31-55
15342241-1	2004	Phosphoglucose isomerase (PGI) is an enzyme of glycolysis that interconverts glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) but, outside the cell, is a multifunctional cytokine.	Glucose-6-Phosphate	77-96	glucose-6-phosphate isomerase 1	Mus musculus	0-24
15342241-1	2004	Phosphoglucose isomerase (PGI) is an enzyme of glycolysis that interconverts glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) but, outside the cell, is a multifunctional cytokine.	Glucose-6-Phosphate	77-96	glucose-6-phosphate isomerase 1	Mus musculus	26-29
15342241-7	2004	The structure with G6P also explains the specificity of PGI for glucose 6-phosphate over mannose 6-isomerase (M6P).	Glucose-6-Phosphate	19-22	glucose-6-phosphate isomerase 1	Mus musculus	56-59
15342241-7	2004	The structure with G6P also explains the specificity of PGI for glucose 6-phosphate over mannose 6-isomerase (M6P).	Glucose-6-Phosphate	64-83	glucose-6-phosphate isomerase 1	Mus musculus	56-59
15024000-3	2004	Activity of the recombinant human MIP synthase purified from Escherichia coli was optimal at pH 8.0 at 37 degrees C and exhibited K(m) values of 0.57 mm and 8 microm for glucose 6-phosphate and NAD(+), respectively.	Glucose-6-Phosphate	170-189	inositol-3-phosphate synthase 1	Homo sapiens	34-46
14985368-1	2004	Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as well as for the induction of glycolytic and lipogenic genes.	Glucose-6-Phosphate	69-88	glucokinase	Mus musculus	8-19
14985368-1	2004	Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as well as for the induction of glycolytic and lipogenic genes.	Glucose-6-Phosphate	69-88	glucokinase	Mus musculus	21-23
14985368-1	2004	Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as well as for the induction of glycolytic and lipogenic genes.	Glucose-6-Phosphate	90-93	glucokinase	Mus musculus	8-19
14985368-1	2004	Hepatic glucokinase (GK) catalyzes the phosphorylation of glucose to glucose 6-phosphate (G6P), a step which is essential for glucose metabolism in liver as well as for the induction of glycolytic and lipogenic genes.	Glucose-6-Phosphate	90-93	glucokinase	Mus musculus	21-23
14765991-1	2004	Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate.	Glucose-6-Phosphate	124-143	glucose-6-phosphatase, catalytic	Mus musculus	0-21
15103138-1	2004	Glucose-6-phosphate isomerase (PGI; EC 5.3.1.9; also often called by its old nomenclature phosphoglucose isomerase) is an intracellular enzyme that catalyses the reversible conversion of D-glucose 6-phosphate (G6P) to D-fructose 6-phosphate (F6P).	Glucose-6-Phosphate	187-208	glucose-6-phosphate isomerase	Homo sapiens	31-34
15103138-1	2004	Glucose-6-phosphate isomerase (PGI; EC 5.3.1.9; also often called by its old nomenclature phosphoglucose isomerase) is an intracellular enzyme that catalyses the reversible conversion of D-glucose 6-phosphate (G6P) to D-fructose 6-phosphate (F6P).	Glucose-6-Phosphate	210-213	glucose-6-phosphate isomerase	Homo sapiens	31-34
14975750-2	2004	The ubiquitous mammalian ATP-dependent hexokinases I-III and hexokinase IV, also termed glucokinase, initiate the process by phosphorylating glucose to glucose-6-phosphate.	Glucose-6-Phosphate	152-171	glucokinase	Homo sapiens	88-99
14688286-9	2004	In conclusion, Pparalpha(-/-) mice were able to maintain a normal total gluconeogenic flux to glucose 6-phosphate during moderate fasting, despite their inability to up-regulate beta-oxidation.	Glucose-6-Phosphate	94-113	peroxisome proliferator activated receptor alpha	Mus musculus	15-24
15357287-2	2004	The purified INOS required NAD+ for the conversion of glucose-6-phosphate to inositol-1-phosphate.	Glucose-6-Phosphate	54-73	myo-inositol-1-phosphate synthase	Drosophila melanogaster	13-17
14746454-1	2004	Two mutations, R69D and K115E, converted a bacterial phosphatidylinositol-specific phospholipase C (PI-PLC) to a phosphatase with much higher specific activity toward glucose-6-phosphate than inositol-1-phosphate.	Glucose-6-Phosphate	167-186	phospholipase C beta 1	Homo sapiens	53-98
14746454-1	2004	Two mutations, R69D and K115E, converted a bacterial phosphatidylinositol-specific phospholipase C (PI-PLC) to a phosphatase with much higher specific activity toward glucose-6-phosphate than inositol-1-phosphate.	Glucose-6-Phosphate	167-186	phospholipase C beta 1	Homo sapiens	100-106
14718531-4	2004	During glucose 6-phosphate (Glc-6-P) hydrolysis, Glc-6-Pase-alpha, a nine-transmembrane domain protein, forms a covalently bound phosphoryl enzyme intermediate through His(176), which lies on the lumenal side of the ER membrane.	Glucose-6-Phosphate	7-26	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	49-59
14718531-4	2004	During glucose 6-phosphate (Glc-6-P) hydrolysis, Glc-6-Pase-alpha, a nine-transmembrane domain protein, forms a covalently bound phosphoryl enzyme intermediate through His(176), which lies on the lumenal side of the ER membrane.	Glucose-6-Phosphate	28-35	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	49-59
14712400-10	2004	It is further postulated that BrdU-positive, GLUT-1-negative glioma cells within the poorly vascularized, central tumor region convert glucose-6-phosphate to nucleotide precursors for DNA replication.	Glucose-6-Phosphate	135-154	solute carrier family 2 member 1	Homo sapiens	45-51
14745035-6	2004	We find that homeostasis is achieved by insulin-dependent phosphorylation changes in GSase sensitivity to the upstream metabolite glucose-6-phosphate.	Glucose-6-Phosphate	130-149	insulin	Homo sapiens	40-47
14765991-1	2004	Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate.	Glucose-6-Phosphate	124-143	glucose-6-phosphatase, catalytic	Mus musculus	23-29
14765991-1	2004	Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate.	Glucose-6-Phosphate	23-26	glucose-6-phosphatase, catalytic	Mus musculus	0-21
14997475-4	2004	Unproblematic detectability of hexokinase and phosphofructokinase demonstrates that the selectivity of synthetic multifunctional pore (SMPs) sensors suffices to sense ATP in mixed analytes containing ADP, whereas detection of the isomerization of glucose 6-phosphate into fructose 6-phosphate by phosphoglucose isomerase is not possible with confidence.	Glucose-6-Phosphate	247-266	hexokinase 1	Homo sapiens	31-41
14715248-1	2004	Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) catalyzes the isomerization between glucose-6-phosphate and fructose-6-phosphate, and is involved in cytokine activity, mitogenesis, differentiation, oncogenesis, and tumor metastasis.	Glucose-6-Phosphate	97-116	glucose-6-phosphate isomerase	Homo sapiens	0-24
14715248-1	2004	Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) catalyzes the isomerization between glucose-6-phosphate and fructose-6-phosphate, and is involved in cytokine activity, mitogenesis, differentiation, oncogenesis, and tumor metastasis.	Glucose-6-Phosphate	97-116	glucose-6-phosphate isomerase	Homo sapiens	25-50
14715248-1	2004	Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) catalyzes the isomerization between glucose-6-phosphate and fructose-6-phosphate, and is involved in cytokine activity, mitogenesis, differentiation, oncogenesis, and tumor metastasis.	Glucose-6-Phosphate	97-116	glucose-6-phosphate isomerase	Homo sapiens	52-55
14561215-6	2004	The effects of HK-I on VDAC activity and PTP opening were prevented by the HK reaction product glucose 6-phosphate, a metabolic intermediate in most biosynthetic pathways.	Glucose-6-Phosphate	95-114	hexokinase 1	Homo sapiens	15-19
13679042-3	2003	Glucose is converted to glucose-6-phosphate by hexokinase that controls almost exclusively the glucose metabolism.	Glucose-6-Phosphate	24-43	hexokinase 1	Homo sapiens	47-57
15061079-3	2004	Acid phosphatase activities with tyrosine phosphate (TyrP), glucose-6-phosphate (G6P) and phosphoenol pyruvate (PEP) were also observed but to a lesser extent.	Glucose-6-Phosphate	60-79	LOC547457	Glycine max	0-16
15061079-3	2004	Acid phosphatase activities with tyrosine phosphate (TyrP), glucose-6-phosphate (G6P) and phosphoenol pyruvate (PEP) were also observed but to a lesser extent.	Glucose-6-Phosphate	81-84	LOC547457	Glycine max	0-16
14586688-1	2003	A simultaneous quantification system of ionic dissociative metabolites was developed using a Fourier transform mid-infrared spectroscopic method by focusing our attention on the enzyme reaction from glucose 6-phosphate to fructose 6-phosphate with phosphoglucose isomerase (PGI).	Glucose-6-Phosphate	199-218	glucose-6-phosphate isomerase	Homo sapiens	248-272
14586688-1	2003	A simultaneous quantification system of ionic dissociative metabolites was developed using a Fourier transform mid-infrared spectroscopic method by focusing our attention on the enzyme reaction from glucose 6-phosphate to fructose 6-phosphate with phosphoglucose isomerase (PGI).	Glucose-6-Phosphate	199-218	glucose-6-phosphate isomerase	Homo sapiens	274-277
32689086-6	2003	Effects of Ca2+ and Mg2+ on A6PR activity were dependent upon both the metal ion concentration and the concentration of Glc6P.	Glucose-6-Phosphate	120-125	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	28-32
32689086-7	2003	The activity of A6PR was increased by 0.5-5 mM Ca2+ or Mg2+ when Glc6P concentration was below 10 mM.	Glucose-6-Phosphate	65-70	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	16-20
32689086-8	2003	However, these same metal ions decreased A6PR activity at greater Glc6P concentrations or in the presence of higher metal ion concentrations.	Glucose-6-Phosphate	66-71	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	41-45
32689086-9	2003	A6PR displayed Michaelis-Menten kinetics either in the presence or absence of 2.5 mM MgCl2, but the apparent Km for Glc6P decreased from 11.3 mM for the control to 5.1 mM in the presence of 2.5 mM MgCl2 in the assay mixture.	Glucose-6-Phosphate	116-121	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	0-4
13129915-3	2003	In the final step of both pathways, glucose-6-phosphate (G6P) is hydrolyzed to glucose by the glucose-6-phosphatase (G6Pase) complex.	Glucose-6-Phosphate	36-55	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	94-115
13129915-3	2003	In the final step of both pathways, glucose-6-phosphate (G6P) is hydrolyzed to glucose by the glucose-6-phosphatase (G6Pase) complex.	Glucose-6-Phosphate	36-55	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	117-123
13129915-3	2003	In the final step of both pathways, glucose-6-phosphate (G6P) is hydrolyzed to glucose by the glucose-6-phosphatase (G6Pase) complex.	Glucose-6-Phosphate	57-60	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	94-115
13129915-3	2003	In the final step of both pathways, glucose-6-phosphate (G6P) is hydrolyzed to glucose by the glucose-6-phosphatase (G6Pase) complex.	Glucose-6-Phosphate	57-60	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	117-123
32689086-4	2003	Inorganic phosphate inhibited A6PR by decreasing the maximum velocity of the enzyme and by increasing the Km for the substrate, glucose-6-phosphate (Glc6P).	Glucose-6-Phosphate	149-154	NADP-dependent D-sorbitol-6-phosphate dehydrogenase	Malus domestica	30-34
13679042-6	2003	Stimulation of glucose-6-phosphate formation via moderate (30-50%) increase of hexokinase activity by adding exogenous hexokinase or tubulin resulted in the slight increase of the relative flux into direction of glycolysis.	Glucose-6-Phosphate	15-34	hexokinase 1	Homo sapiens	79-89
13679042-6	2003	Stimulation of glucose-6-phosphate formation via moderate (30-50%) increase of hexokinase activity by adding exogenous hexokinase or tubulin resulted in the slight increase of the relative flux into direction of glycolysis.	Glucose-6-Phosphate	15-34	hexokinase 1	Homo sapiens	119-129
13679042-8	2003	However, when the activity of hexokinase was doubled with exogenous enzyme, significantly less glucose-6-phosphate was converted into direction of glycolysis than predicted.	Glucose-6-Phosphate	95-114	hexokinase 1	Homo sapiens	30-40
12965222-1	2003	The liver endoplasmic reticulum glucose-6-phosphatase catalytic subunit (G6PC1) catalyses glucose 6-phosphate hydrolysis during gluconeogenesis and glycogenolysis.	Glucose-6-Phosphate	90-109	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	32-53
14507429-5	2003	Here we show that overexpression of Tre6P (as well as glucose-6-phosphate (Glu6P))-insensitive hexokinase from Schizosaccharomyces pombe in a wild-type strain does not affect growth on glucose but still transiently enhances initial sugar phosphate accumulation.	Glucose-6-Phosphate	54-73	hexokinase	Saccharomyces cerevisiae S288C	95-105
14507429-5	2003	Here we show that overexpression of Tre6P (as well as glucose-6-phosphate (Glu6P))-insensitive hexokinase from Schizosaccharomyces pombe in a wild-type strain does not affect growth on glucose but still transiently enhances initial sugar phosphate accumulation.	Glucose-6-Phosphate	75-80	hexokinase	Saccharomyces cerevisiae S288C	95-105
12965222-1	2003	The liver endoplasmic reticulum glucose-6-phosphatase catalytic subunit (G6PC1) catalyses glucose 6-phosphate hydrolysis during gluconeogenesis and glycogenolysis.	Glucose-6-Phosphate	90-109	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	73-78
12965222-2	2003	The highest glucose-6-phosphatase activities are found in the liver and the kidney; there have been many reports of glucose 6-phosphate hydrolysis in other tissues.	Glucose-6-Phosphate	116-135	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	12-33
12965222-4	2003	G6PC3 protein was able to hydrolyse glucose 6-phosphate in transfected Chinese hamster ovary cells.	Glucose-6-Phosphate	36-55	glucose-6-phosphatase 3	Cricetulus griseus	0-5
12965222-5	2003	The optimal pH for glucose 6-phosphate hydrolysis was lower and the K(m) higher relative to G6PC1.	Glucose-6-Phosphate	19-38	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	92-97
12877981-1	2003	In the de novo synthesis of inositol, the conversion of D-glucose-6-phosphate to L-myo-inositol-1-phosphate (MIP) is catalyzed by MIP synthase.	Glucose-6-Phosphate	56-77	myo-inositol 1-phosphate synthase A1	Mus musculus	130-142
12878201-1	2003	Glucose-6-phosphatase (G6Pase) is a multicomponent enzyme system which regulates the catalysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	98-117	glucose-6-phosphatase, catalytic	Mus musculus	0-21
12878201-1	2003	Glucose-6-phosphatase (G6Pase) is a multicomponent enzyme system which regulates the catalysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	98-117	glucose-6-phosphatase, catalytic	Mus musculus	23-29
12878201-1	2003	Glucose-6-phosphatase (G6Pase) is a multicomponent enzyme system which regulates the catalysis of glucose-6-phosphate (G6P) to glucose and inorganic phosphate.	Glucose-6-Phosphate	23-26	glucose-6-phosphatase, catalytic	Mus musculus	0-21
12941759-9	2003	Since suppression of glycogenolysis occurred without a decrease in UDP-glucose flux, this implies that insulin inhibits EGP, at least in part, by directing glucose-6-phosphate into glycogen rather than through the glucose-6-phosphatase pathway.	Glucose-6-Phosphate	156-175	insulin	Homo sapiens	103-110
12777791-1	2003	Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate.	Glucose-6-Phosphate	99-118	glucose-6-phosphate isomerase	Homo sapiens	0-24
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	15-22	glucokinase	Homo sapiens	130-141
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	15-22	glucokinase	Homo sapiens	143-145
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	15-22	hexokinase 1	Homo sapiens	249-261
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	15-22	hexokinase 1	Homo sapiens	263-267
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	85-92	glucokinase	Homo sapiens	130-141
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	85-92	glucokinase	Homo sapiens	143-145
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	85-92	hexokinase 1	Homo sapiens	249-261
12829248-6	2003	The potency of Glc-6-P for activation of liver GS is determined by its source, since Glc-6-P arising from the catalytic action of glucokinase (GK) is much more effective in mediating the activation of the enzyme than the same metabolite produced by hexokinase I (HK I).	Glucose-6-Phosphate	85-92	hexokinase 1	Homo sapiens	263-267
12781768-7	2003	In the case of maize C4-PEPC, the putative binding site for an allosteric activator (glucose 6-phosphate) was also revealed.	Glucose-6-Phosphate	85-104	MLO-like protein 4	Zea mays	24-28
12777791-1	2003	Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate.	Glucose-6-Phosphate	99-118	glucose-6-phosphate isomerase	Homo sapiens	26-29
12560945-5	2003	Five mutants lack microsomal G6P uptake activity and one retains residual activity, suggesting that in G6PT the signature motif is a functional element required for microsomal glucose-6-phosphate transport.	Glucose-6-Phosphate	176-195	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	103-107
12796298-3	2003	The yeast Saccharomyces cerevisiae has three enzymes (Hxk1p, Hxk2p, and Glk1p) that convert glucose to Glc-6-P.	Glucose-6-Phosphate	103-110	hexokinase 2	Saccharomyces cerevisiae S288C	61-66
12796298-3	2003	The yeast Saccharomyces cerevisiae has three enzymes (Hxk1p, Hxk2p, and Glk1p) that convert glucose to Glc-6-P.	Glucose-6-Phosphate	103-110	glucokinase	Saccharomyces cerevisiae S288C	72-77
12744667-6	2003	On the other hand, glucose-6-phosphate enhanced retro-aldol reactions initiated from a C-6 hydroxyl group and increased the subsequent formation of furfural and 4-cyclopentene-1,3-dione.	Glucose-6-Phosphate	19-38	complement C6	Homo sapiens	87-90
12765941-7	2003	The inhibition of glycogenolysis and inactivation of phosphorylase-a caused by 10 mmol/l glucose can be at least in part counteracted by inhibition of glucokinase with 5-thioglucose, which lowers G6P.	Glucose-6-Phosphate	196-199	glucokinase	Homo sapiens	151-162
12676650-5	2003	Measurements of intracellular glucose 6-phosphate, fructose 1,6-bisphosphate, and pyruvate levels, as well as glycolytic flux, in glucose-stimulated GIP/Ins cells indicated that glycolysis was not impaired.	Glucose-6-Phosphate	30-49	gastric inhibitory polypeptide	Mus musculus	149-152
12700167-12	2003	Thus, raised intracellular glucose/glucose 6-phosphate levels reduce mutant huntingtin toxicity by increasing autophagy via mTOR and possibly Akt.	Glucose-6-Phosphate	35-54	huntingtin	Canis lupus familiaris	76-86
12700167-12	2003	Thus, raised intracellular glucose/glucose 6-phosphate levels reduce mutant huntingtin toxicity by increasing autophagy via mTOR and possibly Akt.	Glucose-6-Phosphate	35-54	mechanistic target of rapamycin kinase	Canis lupus familiaris	124-128
12841356-6	2003	The glycation of FGF-2 with 250 mmol/l glucose-6-phosphate led to reduced mitogenic activity compared to native FGF-2.	Glucose-6-Phosphate	39-58	fibroblast growth factor 2	Bos taurus	17-22
12595702-1	2003	Phosphoglucose isomerase (PGI) is a housekeeping enzyme of metabolism that catalyses the interconversion of glucose 6-phosphate and fructose 6-phosphate, with roles in the glycolytic and gluconeogenic pathways.	Glucose-6-Phosphate	108-127	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
12510058-11	2003	We conclude that O-GlcNAc modification of glycogen synthase results in the retention of the enzyme in a glucose 6-phosphate-dependent state and contributes to the reduced activation of the enzyme in insulin resistance.	Glucose-6-Phosphate	104-123	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	17-25
12519761-0	2003	Glucose 6-phosphate produced by gluconeogenesis and by glucokinase is equally effective in activating hepatic glycogen synthase.	Glucose-6-Phosphate	0-19	glucokinase	Homo sapiens	55-66
12519761-4	2003	Our results indicate that the gluconeogenic pathway and the glucokinase-mediated phosphorylation of glucose deliver their common product to the same Glc-6-P pool, which is accessible to liver GS.	Glucose-6-Phosphate	149-156	glucokinase	Homo sapiens	60-71
12595702-1	2003	Phosphoglucose isomerase (PGI) is a housekeeping enzyme of metabolism that catalyses the interconversion of glucose 6-phosphate and fructose 6-phosphate, with roles in the glycolytic and gluconeogenic pathways.	Glucose-6-Phosphate	108-127	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
12582889-2	2002	Myo-inositol 1-phosphate synthase (MIPS; EC 5.5.1.4) converts glucose 6-phosphate to myo-inositol 1-phosphate in the presence of NAD(+).	Glucose-6-Phosphate	62-81	myo-inositol-3-phosphate synthase	Glycine max	0-33
12897415-4	2003	The activity of studied enzymes: acetylcholinesterase (Ache), dehydrogenase glucose-6-phosphate (G-6-PD) and glutathione reductase (GR) maintained their physiological values in both dialysis groups.	Glucose-6-Phosphate	76-95	glucose-6-phosphate dehydrogenase	Homo sapiens	97-103
12485600-2	2002	The glucose-6-phosphate carrier is called G6PT1.	Glucose-6-Phosphate	4-23	solute carrier family 37 member 4	Rattus norvegicus	42-47
12485600-6	2002	Moreover, a different glucose-6-phosphate translocase, representing 20% of total glucose-6-phosphate transport and insensitive to N-ethylmaleimide modification, could coexist with liver G6PT1.	Glucose-6-Phosphate	22-41	solute carrier family 37 member 4	Rattus norvegicus	186-191
12410639-1	2003	In muscle, insulin enhances influx of glucose and its conversion to glucose 6-phosphate (G6P) by hexokinase (HK).	Glucose-6-Phosphate	68-87	insulin	Homo sapiens	11-18
12410639-1	2003	In muscle, insulin enhances influx of glucose and its conversion to glucose 6-phosphate (G6P) by hexokinase (HK).	Glucose-6-Phosphate	68-87	hexokinase 1	Homo sapiens	97-107
12410639-1	2003	In muscle, insulin enhances influx of glucose and its conversion to glucose 6-phosphate (G6P) by hexokinase (HK).	Glucose-6-Phosphate	68-87	hexokinase 1	Homo sapiens	109-111
12410639-1	2003	In muscle, insulin enhances influx of glucose and its conversion to glucose 6-phosphate (G6P) by hexokinase (HK).	Glucose-6-Phosphate	89-92	insulin	Homo sapiens	11-18
12410639-1	2003	In muscle, insulin enhances influx of glucose and its conversion to glucose 6-phosphate (G6P) by hexokinase (HK).	Glucose-6-Phosphate	89-92	hexokinase 1	Homo sapiens	97-107
12410639-1	2003	In muscle, insulin enhances influx of glucose and its conversion to glucose 6-phosphate (G6P) by hexokinase (HK).	Glucose-6-Phosphate	89-92	hexokinase 1	Homo sapiens	109-111
15303374-1	2003	Deformability and activity of the enzymes: acetylcholinesterase (AChE) and dehydrogenase glucose-6-phosphate (G-6-PD), were assayed for RBC enriched in immature reticulocytes.	Glucose-6-Phosphate	89-108	glucose-6-phosphate dehydrogenase	Rattus norvegicus	110-116
12582889-2	2002	Myo-inositol 1-phosphate synthase (MIPS; EC 5.5.1.4) converts glucose 6-phosphate to myo-inositol 1-phosphate in the presence of NAD(+).	Glucose-6-Phosphate	62-81	myo-inositol-3-phosphate synthase	Glycine max	35-39
12401705-1	2002	The direct acute effects of insulin on the regulation of hepatic gluconeogenic flux to glucose-6-phosphate (G6P) in vivo may be masked by the hormone"s effects on net hepatic glycogenolytic flux and the resulting changes in glycolysis.	Glucose-6-Phosphate	87-106	insulin	Canis lupus familiaris	28-35
12401705-1	2002	The direct acute effects of insulin on the regulation of hepatic gluconeogenic flux to glucose-6-phosphate (G6P) in vivo may be masked by the hormone"s effects on net hepatic glycogenolytic flux and the resulting changes in glycolysis.	Glucose-6-Phosphate	108-111	insulin	Canis lupus familiaris	28-35
12373565-4	2002	To explain the function of the G6Pase complex, a multicomponent translocase catalytic model has been proposed in which different transporters shuttle glucose-6-phosphate (G6P), inorganic phosphate (Pi) and glucose across the microsomal membrane.	Glucose-6-Phosphate	150-169	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	31-37
12368100-1	2002	Phosphoglucose isomerase (PGI; EC 5.3.1.9) is the second enzyme in glycolysis, where it catalyzes the isomerization of D-glucose-6-phosphate to D-fructose-6-phosphate.	Glucose-6-Phosphate	119-140	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
12368100-1	2002	Phosphoglucose isomerase (PGI; EC 5.3.1.9) is the second enzyme in glycolysis, where it catalyzes the isomerization of D-glucose-6-phosphate to D-fructose-6-phosphate.	Glucose-6-Phosphate	119-140	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
12373575-1	2002	UNLABELLED: Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose.	Glucose-6-Phosphate	192-195	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	45-49
12373575-1	2002	UNLABELLED: Glycogen storage disease type 1 (GSD1) is an inborn error of metabolism caused by deficiency of glucose-6-phosphatase, the enzyme catalysing the conversion of glucose-6-phosphate (G6P) to glucose.	Glucose-6-Phosphate	171-190	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	45-49
32689502-5	2002	Glucose-6-phosphate (G6P) was found to be an activator of apple SPS, and the activation was dependent upon the F6P concentration.	Glucose-6-Phosphate	21-24	probable sucrose-phosphate synthase 1	Malus domestica	64-67
12093795-8	2002	A 40-kDa [(32)P]phosphate-G6Pase intermediate was identified after incubating [(32)P]glucose 6-phosphate with microsomes expressing wild type but not with microsomes expressing either H119A or H176A mutant G6Pase.	Glucose-6-Phosphate	85-104	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	26-32
11882651-0	2002	Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase.	Glucose-6-Phosphate	74-93	lengsin, lens protein with glutamine synthetase domain	Rattus norvegicus	0-23
11882651-0	2002	Liver glycogen synthase but not the muscle isoform differentiates between glucose 6-phosphate produced by glucokinase or hexokinase.	Glucose-6-Phosphate	74-93	glucokinase	Rattus norvegicus	106-117
11882651-5	2002	Similarly overexpressed MGS was efficiently activated by the glucose-6-phosphate (Glc-6-P) produced by either endogenous or overexpressed HK I and by overexpressed GK.	Glucose-6-Phosphate	61-80	hexokinase 1	Rattus norvegicus	138-142
11882651-5	2002	Similarly overexpressed MGS was efficiently activated by the glucose-6-phosphate (Glc-6-P) produced by either endogenous or overexpressed HK I and by overexpressed GK.	Glucose-6-Phosphate	61-80	glucokinase	Rattus norvegicus	164-166
11882651-5	2002	Similarly overexpressed MGS was efficiently activated by the glucose-6-phosphate (Glc-6-P) produced by either endogenous or overexpressed HK I and by overexpressed GK.	Glucose-6-Phosphate	82-89	hexokinase 1	Rattus norvegicus	138-142
11882651-5	2002	Similarly overexpressed MGS was efficiently activated by the glucose-6-phosphate (Glc-6-P) produced by either endogenous or overexpressed HK I and by overexpressed GK.	Glucose-6-Phosphate	82-89	glucokinase	Rattus norvegicus	164-166
11882651-6	2002	These results indicate the existence of at least two pools of Glc-6-P in the cell, one of them is accessible to both isoforms of GS and is replenished by the action of GK, whereas LGS is excluded from the cellular compartment where the Glc-6-P produced by HK I is directed.	Glucose-6-Phosphate	62-69	glucokinase	Rattus norvegicus	168-170
11882651-6	2002	These results indicate the existence of at least two pools of Glc-6-P in the cell, one of them is accessible to both isoforms of GS and is replenished by the action of GK, whereas LGS is excluded from the cellular compartment where the Glc-6-P produced by HK I is directed.	Glucose-6-Phosphate	62-69	lengsin, lens protein with glutamine synthetase domain	Rattus norvegicus	180-183
11882651-6	2002	These results indicate the existence of at least two pools of Glc-6-P in the cell, one of them is accessible to both isoforms of GS and is replenished by the action of GK, whereas LGS is excluded from the cellular compartment where the Glc-6-P produced by HK I is directed.	Glucose-6-Phosphate	62-69	hexokinase 1	Rattus norvegicus	256-260
12370122-1	2002	Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate.	Glucose-6-Phosphate	124-143	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
12370122-1	2002	Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate.	Glucose-6-Phosphate	124-143	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	23-29
12370122-1	2002	Glucose-6-phosphatase (G6Pase) catalyzes the final step in the gluconeogenic and glycogenolytic pathways, the hydrolysis of glucose-6-phosphate (G6P) to glucose and phosphate.	Glucose-6-Phosphate	23-26	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
12124227-6	2002	This was associated with sustained creatine kinase flux and elevated cellular glucose-6-phosphate levels as the cellular energetic system adapted to deletion of AK1.	Glucose-6-Phosphate	78-97	adenylate kinase 1	Mus musculus	161-164
12054929-6	2002	Clearly, DOIS recognizes the G-6-P substrate through specific hydrogen-bonding interactions, i.e., through a hydrogen-donating group for C-2 and an accepting group for C-3 of the substrate.	Glucose-6-Phosphate	29-34	complement C2	Homo sapiens	137-140
12054929-6	2002	Clearly, DOIS recognizes the G-6-P substrate through specific hydrogen-bonding interactions, i.e., through a hydrogen-donating group for C-2 and an accepting group for C-3 of the substrate.	Glucose-6-Phosphate	29-34	complement C3	Homo sapiens	168-171
32689502-6	2002	At a concentration of 2 mM, G6P significantly decreased the Km for F6P and increased SPS activity.	Glucose-6-Phosphate	28-31	probable sucrose-phosphate synthase 1	Malus domestica	85-88
32689502-11	2002	Sorbitol-6-phosphate also inhibited G6P activation of SPS.	Glucose-6-Phosphate	36-39	probable sucrose-phosphate synthase 1	Malus domestica	54-57
12062448-2	2002	In this paper, we show that S3483, a chlorogenic acid derivative known to inhibit glucose-6-phosphatase in intact microsomes, caused the intravesicular accumulation of glucose-6-phosphate when the latter was produced by glucose-6-phosphatase from glucose and carbamoyl-phosphate.	Glucose-6-Phosphate	168-187	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	82-103
11983887-1	2002	Phosphoglucose isomerase (EC ) catalyzes the second step in glycolysis, the reversible isomerization of D-glucose 6-phosphate to D-fructose 6-phosphate.	Glucose-6-Phosphate	104-125	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
12062448-2	2002	In this paper, we show that S3483, a chlorogenic acid derivative known to inhibit glucose-6-phosphatase in intact microsomes, caused the intravesicular accumulation of glucose-6-phosphate when the latter was produced by glucose-6-phosphatase from glucose and carbamoyl-phosphate.	Glucose-6-Phosphate	168-187	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	220-241
11516168-8	2001	These results demonstrate that the catalytic unit and G6PT components of the G6Pase system can be discriminantly regulated, and that microsomal glucose 6-phosphate uptake is dependent on catalytic unit activity as well as G6PT action.	Glucose-6-Phosphate	144-163	glucose-6-phosphatase, catalytic	Mus musculus	222-226
11949931-4	2002	G6PT translocates glucose-6-phosphate (G6P) from the cytoplasm into the lumen of the ER, where G6Pase hydrolyses the G6P into glucose and phosphate.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	95-101
11949931-4	2002	G6PT translocates glucose-6-phosphate (G6P) from the cytoplasm into the lumen of the ER, where G6Pase hydrolyses the G6P into glucose and phosphate.	Glucose-6-Phosphate	39-42	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-4
11949931-4	2002	G6PT translocates glucose-6-phosphate (G6P) from the cytoplasm into the lumen of the ER, where G6Pase hydrolyses the G6P into glucose and phosphate.	Glucose-6-Phosphate	39-42	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	95-101
11852566-1	2002	Inactivation of glucose 6-phosphate dehydrogenase (G6PDH) complexed with its substrate, glucose 6-phosphate (GP), and/or cofactor, NADP+, has been studied within the range 20-40 degrees C in three media: (a) 0.04 M NaOH-glycine buffer (pH 9.1); (b) Aerosol OT (AOT) reversed micelles in octane; and (c) Triton X-100 micelles in octane supplemented with 10% hexanol.	Glucose-6-Phosphate	16-35	glucose-6-phosphate dehydrogenase	Homo sapiens	51-56
11753757-3	2001	It has previously been shown that sulfated steroids, such as estrone sulfate and dehydroepiandrosterone sulfate, inhibit the glucose-6-phosphatase system in vitro, principally through inhibition of endoplasmic reticulum glucose-6-phosphate transport.	Glucose-6-Phosphate	220-239	glucose-6-phosphatase, catalytic	Mus musculus	125-146
11551847-1	2001	The regulation of glucose-6-phosphatase (G-6-Pase) catalytic subunit and glucose 6-phosphate (G-6-P) transporter gene expression by insulin in conscious dogs in vivo and in tissue culture cells in situ were compared.	Glucose-6-Phosphate	73-92	insulin	Canis lupus familiaris	132-139
11562503-7	2001	Together our data demonstrate the existence of a transepithelial glucose transport system in GLUT2(-/-) intestine that requires glucose phosphorylation and transfer of glucose-6-phosphate into the endoplasmic reticulum.	Glucose-6-Phosphate	168-187	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	93-98
11516168-2	2001	The V(max) for glucose 6-phosphate hydrolysis by G6Pase was reduced by 40% and a greater than 15-fold decrease in mRNA encoding the catalytic unit of the G6Pase system was observed 8 days after injection with tumor cells.	Glucose-6-Phosphate	15-34	glucose-6-phosphatase, catalytic	Mus musculus	49-55
11516168-2	2001	The V(max) for glucose 6-phosphate hydrolysis by G6Pase was reduced by 40% and a greater than 15-fold decrease in mRNA encoding the catalytic unit of the G6Pase system was observed 8 days after injection with tumor cells.	Glucose-6-Phosphate	15-34	glucose-6-phosphatase, catalytic	Mus musculus	154-160
11516168-8	2001	These results demonstrate that the catalytic unit and G6PT components of the G6Pase system can be discriminantly regulated, and that microsomal glucose 6-phosphate uptake is dependent on catalytic unit activity as well as G6PT action.	Glucose-6-Phosphate	144-163	glucose-6-phosphatase, catalytic	Mus musculus	77-83
11756655-0	2002	Hpt, a bacterial homolog of the microsomal glucose- 6-phosphate translocase, mediates rapid intracellular proliferation in Listeria.	Glucose-6-Phosphate	43-63	MRS2 magnesium transporter	Mus musculus	0-3
11756655-3	2002	HP uptake is mediated by Hpt, a bacterial homolog of the mammalian translocase that transports glucose-6-phosphate from the cytosol into the endoplasmic reticulum in the final step of gluconeogenesis and glycogenolysis.	Glucose-6-Phosphate	95-114	HPT	Homo sapiens	25-28
11724581-10	2001	Via a suppression of glycolysis, the inactivation of 6-phosphofructo-2-kinase is expected to be responsible for the observed accumulation of glucose 6-phosphate, an essential precursor of the cell wall glucans, and the decrease of glycerol, an important osmolyte.	Glucose-6-Phosphate	141-160	6-phosphofructo-2-kinase	Saccharomyces cerevisiae S288C	53-77
11535127-4	2001	Inhibition of glucose-6-phosphate translocase increased intracellular glucose 6-phosphate (3-fold), glycogen accumulation (5-fold) without change in active (dephosphorylated) glycogen synthase (GSa) activity, and lactate production (4-fold).	Glucose-6-Phosphate	70-89	solute carrier family 37 member 4	Rattus norvegicus	14-45
11457850-2	2001	6-Phosphogluconolactonase is the second enzyme of the oxidative branch and catalyzes the hydrolysis of 6-phosphogluconolactones, the products of glucose 6-phosphate oxidation by glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	145-164	6-phosphogluconolactonase	Homo sapiens	0-25
11457850-2	2001	6-Phosphogluconolactonase is the second enzyme of the oxidative branch and catalyzes the hydrolysis of 6-phosphogluconolactones, the products of glucose 6-phosphate oxidation by glucose-6-phosphate dehydrogenase.	Glucose-6-Phosphate	145-164	glucose-6-phosphate dehydrogenase	Homo sapiens	178-211
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	76-97	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
11527579-2	2001	Allosteric activators such as D-glucose-6-phosphate and glycine increase the affinity of PEPC for its substrate PEP at pH 8.0 and pH 7.0.	Glucose-6-Phosphate	30-51	MLO-like protein 4	Zea mays	89-93
11527579-2	2001	Allosteric activators such as D-glucose-6-phosphate and glycine increase the affinity of PEPC for its substrate PEP at pH 8.0 and pH 7.0.	Glucose-6-Phosphate	30-51	phosphoenolpyruvate carboxylase 2	Zea mays	89-92
11560776-2	2001	The G6PT protein translocates glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum, where glucose-6-phosphatase metabolizes it to glucose and phosphate.	Glucose-6-Phosphate	30-49	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	4-8
11560776-2	2001	The G6PT protein translocates glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum, where glucose-6-phosphatase metabolizes it to glucose and phosphate.	Glucose-6-Phosphate	30-49	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	118-139
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	76-97	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	99-102	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-24
11425306-1	2001	Phosphoglucose isomerase (PGI, EC 5.3.1.9) catalyzes the interconversion of D-glucose 6-phosphate (G6P) and D-fructose 6-phosphate (F6P) and plays important roles in glycolysis and gluconeogenesis.	Glucose-6-Phosphate	99-102	glucose-6-phosphate isomerase	Oryctolagus cuniculus	26-29
11388797-4	2001	Among these isoenzymes, hexokinase type I is the most widely expressed in mammalian tissues and shows reversion of Glc 6-P inhibition by physiological levels of inorganic phosphate.	Glucose-6-Phosphate	115-122	hexokinase 1	Homo sapiens	24-41
11458018-3	2001	Low intracellular glucose and glucose-6-phosphate concentrations indicate that decreased glucose transport is mainly responsible for common insulin resistance.	Glucose-6-Phosphate	30-49	insulin	Homo sapiens	140-147
11346646-12	2001	Thus, acute inhibition of glucose-6-phosphatase activity by S4048 elicited 1) a repartitioning of newly synthesized Glc-6-P from glucose production into glycogen synthesis without affecting the gluconeogenic flux to Glc-6-P and 2) a cellular response aimed at maintaining cellular Glc-6-P homeostasis.	Glucose-6-Phosphate	116-123	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	26-47
11346646-12	2001	Thus, acute inhibition of glucose-6-phosphatase activity by S4048 elicited 1) a repartitioning of newly synthesized Glc-6-P from glucose production into glycogen synthesis without affecting the gluconeogenic flux to Glc-6-P and 2) a cellular response aimed at maintaining cellular Glc-6-P homeostasis.	Glucose-6-Phosphate	216-223	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	26-47
11346646-12	2001	Thus, acute inhibition of glucose-6-phosphatase activity by S4048 elicited 1) a repartitioning of newly synthesized Glc-6-P from glucose production into glycogen synthesis without affecting the gluconeogenic flux to Glc-6-P and 2) a cellular response aimed at maintaining cellular Glc-6-P homeostasis.	Glucose-6-Phosphate	216-223	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	26-47
11594461-1	2001	Glucokinase catalyzes phosphoryl group transfer from ATP to glucose to form glucose-6-phosphate in the first step of cellular metabolism.	Glucose-6-Phosphate	76-95	glucokinase	Homo sapiens	0-11
11357483-6	2001	The partial recovery of glucokinase activity, not found in diabetic animals, normalised glycogen and glucose 6-phosphate concentrations.	Glucose-6-Phosphate	101-120	glucokinase	Rattus norvegicus	24-35
11246869-1	2001	Glucose-6-phosphatase (G6Pase) is a multicomponent system located in the endoplasmic reticulum comprising a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose.	Glucose-6-Phosphate	147-166	glucose-6-phosphatase, catalytic	Mus musculus	0-21
11283248-7	2001	In skeletal muscle, the glycogen synthase (GS) activity ratio in the absence and presence of glucose-6-phosphate is reduced from 0.3 in the wild type to 0.1 in the null mutant RGL mice, whereas the phosphorylase activity ratio in the absence and presence of AMP is increased from 0.4 to 0.7.	Glucose-6-Phosphate	93-112	protein phosphatase 1, regulatory subunit 3A	Mus musculus	176-179
11899241-2	2001	G6PT translocates glucose-6-phosphate (G6P) from cytoplasm to the lumen of the endoplasmic reticulum (ER) and G6Pase catalyzes the hydrolysis of G6P to produce glucose and phosphate.	Glucose-6-Phosphate	18-37	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-4
11899241-2	2001	G6PT translocates glucose-6-phosphate (G6P) from cytoplasm to the lumen of the endoplasmic reticulum (ER) and G6Pase catalyzes the hydrolysis of G6P to produce glucose and phosphate.	Glucose-6-Phosphate	18-37	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	110-116
11899241-2	2001	G6PT translocates glucose-6-phosphate (G6P) from cytoplasm to the lumen of the endoplasmic reticulum (ER) and G6Pase catalyzes the hydrolysis of G6P to produce glucose and phosphate.	Glucose-6-Phosphate	0-3	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	110-116
11899241-2	2001	G6PT translocates glucose-6-phosphate (G6P) from cytoplasm to the lumen of the endoplasmic reticulum (ER) and G6Pase catalyzes the hydrolysis of G6P to produce glucose and phosphate.	Glucose-6-Phosphate	39-42	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-4
11899241-2	2001	G6PT translocates glucose-6-phosphate (G6P) from cytoplasm to the lumen of the endoplasmic reticulum (ER) and G6Pase catalyzes the hydrolysis of G6P to produce glucose and phosphate.	Glucose-6-Phosphate	39-42	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	110-116
11330472-1	2001	The interaction of aluminium(III) with glucose-6-phosphate (GP: LH2) in aqueous solutions has been studied from pH 1 to pH 8, by pH-potentiometry and multinuclear (31P, 27Al, 13C) NMR spectroscopy.	Glucose-6-Phosphate	39-58	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	Homo sapiens	64-67
11246869-1	2001	Glucose-6-phosphatase (G6Pase) is a multicomponent system located in the endoplasmic reticulum comprising a catalytic subunit and transporters for glucose-6-phosphate, inorganic phosphate, and glucose.	Glucose-6-Phosphate	147-166	glucose-6-phosphatase, catalytic	Mus musculus	23-29
10998419-9	2000	We conclude that PTG overexpression activates glycogen synthesis in a glucose 6-phosphate-independent manner in human muscle cells while overriding glycogen-mediated inhibition.	Glucose-6-Phosphate	70-89	protein phosphatase 1 regulatory subunit 3C	Homo sapiens	17-20
12197473-5	2001	FGF-2 was exposed to 0.25 M glucose-6-phosphate (G-6-P) for 24-72 h and the degree of glycation determined by matrix assisted laser desorption ionisation mass spectrometry.	Glucose-6-Phosphate	28-47	fibroblast growth factor 2	Homo sapiens	0-5
12197473-5	2001	FGF-2 was exposed to 0.25 M glucose-6-phosphate (G-6-P) for 24-72 h and the degree of glycation determined by matrix assisted laser desorption ionisation mass spectrometry.	Glucose-6-Phosphate	49-54	fibroblast growth factor 2	Homo sapiens	0-5
12197473-13	2001	In summary, glycation of FGF-2 in vitro occurs rapidly within 24 h in the presence of elevated levels of G-6-P.	Glucose-6-Phosphate	105-110	fibroblast growth factor 2	Homo sapiens	25-30
11171165-3	2000	The effect is dependent on the acyl chain length, e.g. lauryl-CoA is less inhibitory than oleoyl-CoA, causing 34 and 68% inhibition respectively of Glc-6-P uptake after 30 s. The inhibition of Glc-6-P and ATP transport is alleviated by addition of an equivalent concentration of acyl-CoA-binding protein (ACBP) or BSA.	Glucose-6-Phosphate	148-155	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	279-303
11171165-3	2000	The effect is dependent on the acyl chain length, e.g. lauryl-CoA is less inhibitory than oleoyl-CoA, causing 34 and 68% inhibition respectively of Glc-6-P uptake after 30 s. The inhibition of Glc-6-P and ATP transport is alleviated by addition of an equivalent concentration of acyl-CoA-binding protein (ACBP) or BSA.	Glucose-6-Phosphate	148-155	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	305-309
11171165-3	2000	The effect is dependent on the acyl chain length, e.g. lauryl-CoA is less inhibitory than oleoyl-CoA, causing 34 and 68% inhibition respectively of Glc-6-P uptake after 30 s. The inhibition of Glc-6-P and ATP transport is alleviated by addition of an equivalent concentration of acyl-CoA-binding protein (ACBP) or BSA.	Glucose-6-Phosphate	193-200	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	279-303
11171165-3	2000	The effect is dependent on the acyl chain length, e.g. lauryl-CoA is less inhibitory than oleoyl-CoA, causing 34 and 68% inhibition respectively of Glc-6-P uptake after 30 s. The inhibition of Glc-6-P and ATP transport is alleviated by addition of an equivalent concentration of acyl-CoA-binding protein (ACBP) or BSA.	Glucose-6-Phosphate	193-200	diazepam binding inhibitor, acyl-CoA binding protein	Homo sapiens	305-309
10962105-6	2000	The molten globule states of gamma-crystallin and myoglobin were prepared by reacting gamma-crystallin with glucose 6-phosphate and by removing the haem group of myoglobin.	Glucose-6-Phosphate	108-127	myoglobin	Homo sapiens	50-59
10960498-2	2000	A variant (GSD 1b) is caused by a defect in the transport of glucose-6-phosphate (G6P) into the microsome and is associated with chronic neutropenia and neutrophil dysfunction.	Glucose-6-Phosphate	61-80	solute carrier family 37 member 4	Homo sapiens	11-17
10960498-2	2000	A variant (GSD 1b) is caused by a defect in the transport of glucose-6-phosphate (G6P) into the microsome and is associated with chronic neutropenia and neutrophil dysfunction.	Glucose-6-Phosphate	82-85	solute carrier family 37 member 4	Homo sapiens	11-17
11078441-7	2000	Inhibition of hexokinase in rat and human muscle by long-chain acyl CoAs was additive to the inhibition of hexokinase by glucose-6-phosphate (an allosteric inhibitor of hexokinase).	Glucose-6-Phosphate	121-140	hexokinase 1	Homo sapiens	107-117
11078441-7	2000	Inhibition of hexokinase in rat and human muscle by long-chain acyl CoAs was additive to the inhibition of hexokinase by glucose-6-phosphate (an allosteric inhibitor of hexokinase).	Glucose-6-Phosphate	121-140	hexokinase 1	Homo sapiens	107-117
11078441-8	2000	This inhibition of skeletal muscle hexokinase by long-chain acyl CoA suggests that increases in intramuscular lipid metabolites could interact directly with insulin-mediated glucose metabolism in vivo by decreasing the rate of glucose phosphorylation and decreasing glucose-6-phosphate concentrations.	Glucose-6-Phosphate	266-285	hexokinase 1	Homo sapiens	35-45
11078441-8	2000	This inhibition of skeletal muscle hexokinase by long-chain acyl CoA suggests that increases in intramuscular lipid metabolites could interact directly with insulin-mediated glucose metabolism in vivo by decreasing the rate of glucose phosphorylation and decreasing glucose-6-phosphate concentrations.	Glucose-6-Phosphate	266-285	insulin	Homo sapiens	157-164
11063694-9	2000	There is evidence for accelerated amino acid substitution in Hex-t1 that has lost residues known to be associated with glucose and glucose-6-phosphate binding.	Glucose-6-Phosphate	131-150	Hex-t1	Drosophila melanogaster	61-67
10950853-3	2000	Our current investigation evaluated the FMO isoform specificity of DAK in a pyrophosphate buffer (pH 8.8) containing the glucose 6-phosphate NADPH-generating system.	Glucose-6-Phosphate	121-140	triokinase and FMN cyclase	Homo sapiens	67-70
10826998-8	2000	In contrast, the increase in G-6-P level in the exercise-trained group was accompanied by increased GLUT-4 protein content and hexokinase II (cytosolic) and GS activities.	Glucose-6-Phosphate	29-34	solute carrier family 2 member 4	Rattus norvegicus	100-106
10770936-1	2000	Phosphoglucose isomerase catalyzes the reversible isomerization of glucose 6-phosphate to fructose 6-phosphate.	Glucose-6-Phosphate	67-86	glucose-6-phosphate isomerase 1	Mus musculus	0-24
10764781-3	2000	Expression of the hexokinase transgene in the context of the Glut1 transgenic background did not alter glucose transport in isolated muscles but did cause additional increases in steady-state glucose 6-phosphate (3.2-fold) and glycogen (7.5-fold) levels compared with muscles that overexpress the Glut1 transporter alone.	Glucose-6-Phosphate	192-211	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	61-66
10749890-1	2000	Hexokinase is the first enzyme in the glycolytic pathway, catalyzing the transfer of a phosphoryl group from ATP to glucose to form glucose 6-phosphate and ADP.	Glucose-6-Phosphate	132-151	hexokinase	Saccharomyces cerevisiae S288C	0-10
10954083-9	2000	The substrate for PGM, glucose 6-phosphate, accumulated in stf1 during the day, resulting in 10-fold higher content than in the wild type at the end of the photoperiod.	Glucose-6-Phosphate	23-42	phosphoglucomutase	Arabidopsis thaliana	18-21
10954083-9	2000	The substrate for PGM, glucose 6-phosphate, accumulated in stf1 during the day, resulting in 10-fold higher content than in the wild type at the end of the photoperiod.	Glucose-6-Phosphate	23-42	phosphoglucomutase	Arabidopsis thaliana	59-63
10900005-8	2000	Finally, both internalization of CD26 and the T cell proliferative response induced by CD26-mediated costimulation were inhibited by the addition of M6P, but not by glucose 6-phosphate or mannose 1-phosphate.	Glucose-6-Phosphate	165-184	dipeptidyl peptidase 4	Homo sapiens	33-37
10945768-5	2000	The presence of GK activity in skeletal muscle resulted in increased concentrations of glucose 6-phosphate and glycogen.	Glucose-6-Phosphate	87-106	glucokinase	Mus musculus	16-18
10794725-1	2000	The effects of long-chain acyl-CoA (lcACoA) esters (both added exogenously and synthesized de novo) and acyl-CoA binding protein (ACBP) on plastidial glucose 6-phosphate (Glc6P) and pyruvate metabolism were examined using isolated plastids.	Glucose-6-Phosphate	150-169	acyl-CoA-binding protein	Brassica napus	130-134
10794725-2	2000	The binding of lcACoA esters by ACBP stimulated the utilization of Glc6P for fatty acid synthesis, starch synthesis and reductant supply via the oxidative pentose phosphate (OPP) pathway.	Glucose-6-Phosphate	67-72	acyl-CoA-binding protein	Brassica napus	32-36
10794725-5	2000	However, addition of ACBP did increase the Glc6P-dependent stimulation of pyruvate utilization mediated through the OPP pathway.	Glucose-6-Phosphate	43-48	acyl-CoA-binding protein	Brassica napus	21-25
10794725-6	2000	On the basis of these experiments, we conclude that lcACoA esters may inhibit Glc6P uptake into plastids, and that this inhibition is relieved by ACBP.	Glucose-6-Phosphate	78-83	acyl-CoA-binding protein	Brassica napus	146-150
10834514-1	2000	UNLABELLED: Glucose-6-phosphatase is a multicomponent enzymatic system of the endoplasmic reticulum, which catalyses the terminal steps of gluconeogenesis and glycogenolysis by converting glucose-6-phosphate to glucose and inorganic phosphate.	Glucose-6-Phosphate	188-207	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	12-33
10905493-2	2000	The rate-controlling steps of insulin-stimulated muscle glucose metabolism were assessed using 31P-NMR spectroscopic measurement of intramuscular glucose-6-phosphate (G-6-P) combined with a novel 13C-NMR method to assess intracellular glucose concentrations.	Glucose-6-Phosphate	146-165	insulin	Homo sapiens	30-37
10905493-2	2000	The rate-controlling steps of insulin-stimulated muscle glucose metabolism were assessed using 31P-NMR spectroscopic measurement of intramuscular glucose-6-phosphate (G-6-P) combined with a novel 13C-NMR method to assess intracellular glucose concentrations.	Glucose-6-Phosphate	167-172	insulin	Homo sapiens	30-37
11467410-5	2000	Compared to pre-dosing, insulin-stimulated GS activity and G6P content were increased by this TZD: GS independent activity (p = 0.02), GS total activity (p = 0.005), GS fractional activity (p = 0.06) and G6P content (p = 0.02).	Glucose-6-Phosphate	59-62	insulin	Homo sapiens	24-31
10694370-1	2000	Glucose-6-phosphatase (G-6-Pase) hydrolyzes glucose-6-phosphate to glucose, reciprocal with the so-called glucose sensor, glucokinase, in pancreatic beta cells.	Glucose-6-Phosphate	44-63	glucose-6-phosphatase, catalytic	Mus musculus	0-21
10694370-1	2000	Glucose-6-phosphatase (G-6-Pase) hydrolyzes glucose-6-phosphate to glucose, reciprocal with the so-called glucose sensor, glucokinase, in pancreatic beta cells.	Glucose-6-Phosphate	44-63	glucose-6-phosphatase, catalytic	Mus musculus	23-31
10656921-1	2000	In mammalian tissues, the phosphorylation of intracellular glucose to glucose-6-phosphate (Glu-6-P) is facilitated by four distinct hexokinase (HK) isoenzymes, designated as HKI-IV.	Glucose-6-Phosphate	70-89	hexokinase 1	Homo sapiens	132-142
10656921-1	2000	In mammalian tissues, the phosphorylation of intracellular glucose to glucose-6-phosphate (Glu-6-P) is facilitated by four distinct hexokinase (HK) isoenzymes, designated as HKI-IV.	Glucose-6-Phosphate	70-89	hexokinase 1	Homo sapiens	144-146
10656921-1	2000	In mammalian tissues, the phosphorylation of intracellular glucose to glucose-6-phosphate (Glu-6-P) is facilitated by four distinct hexokinase (HK) isoenzymes, designated as HKI-IV.	Glucose-6-Phosphate	91-98	hexokinase 1	Homo sapiens	132-142
10656921-1	2000	In mammalian tissues, the phosphorylation of intracellular glucose to glucose-6-phosphate (Glu-6-P) is facilitated by four distinct hexokinase (HK) isoenzymes, designated as HKI-IV.	Glucose-6-Phosphate	91-98	hexokinase 1	Homo sapiens	144-146
10620367-2	2000	We used the chlorogenic acid derivative S 3483, a reversible inhibitor of the glucose-6-phosphate (Glc-6-P) translocase component, to demonstrate for the first time upregulation of Glc-6-Pase expression in rat liver in vivo after inhibition of Glc-6-P translocase.	Glucose-6-Phosphate	78-97	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	181-191
10620367-2	2000	We used the chlorogenic acid derivative S 3483, a reversible inhibitor of the glucose-6-phosphate (Glc-6-P) translocase component, to demonstrate for the first time upregulation of Glc-6-Pase expression in rat liver in vivo after inhibition of Glc-6-P translocase.	Glucose-6-Phosphate	99-106	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	181-191
10713523-1	2000	The conversion of glucose 6-phosphate to 1-L-myo-inositol 1--phosphate (MIP) by 1-L-myo-inositol 1-phosphate synthase (MIP synthase) is the first committed and rate-limiting step in the de novo biosynthesis of inositol in all eukaryotes.	Glucose-6-Phosphate	18-37	inositol-3-phosphate synthase 1	Homo sapiens	119-131
10531306-0	1999	Dual mechanisms for glucose 6-phosphate inhibition of human brain hexokinase.	Glucose-6-Phosphate	20-39	hexokinase 1	Homo sapiens	66-76
10542207-11	1999	In glucokinase-overexpressing cells, glucose 6-phosphate levels increased.	Glucose-6-Phosphate	37-56	glucokinase	Rattus norvegicus	3-14
10842666-2	1999	The purpose of the present study was to determine whether this increase in Ka (concentration of glucose 6-phosphate [G6P] at which GS activity is half-maximal) during insulin is also present in very lean (VL) young adult monkeys maintained on a controlled feeding regimen.	Glucose-6-Phosphate	96-115	insulin	Macaca mulatta	167-174
10531306-1	1999	Brain hexokinase (HKI) is inhibited potently by its product glucose 6-phosphate (G6P); however, the mechanism of inhibition is unsettled.	Glucose-6-Phosphate	60-79	hexokinase 1	Homo sapiens	6-16
10531306-1	1999	Brain hexokinase (HKI) is inhibited potently by its product glucose 6-phosphate (G6P); however, the mechanism of inhibition is unsettled.	Glucose-6-Phosphate	60-79	hexokinase 1	Homo sapiens	18-21
10531306-1	1999	Brain hexokinase (HKI) is inhibited potently by its product glucose 6-phosphate (G6P); however, the mechanism of inhibition is unsettled.	Glucose-6-Phosphate	81-84	hexokinase 1	Homo sapiens	6-16
10531306-1	1999	Brain hexokinase (HKI) is inhibited potently by its product glucose 6-phosphate (G6P); however, the mechanism of inhibition is unsettled.	Glucose-6-Phosphate	81-84	hexokinase 1	Homo sapiens	18-21
10531306-3	1999	In one, G6P binds to the active site (the C-terminal half of HKI) and competes directly with ATP, whereas in the alternative suggestion the inhibitor binds to an allosteric site (the N-terminal half of HKI), which indirectly displaces ATP from the active site.	Glucose-6-Phosphate	8-11	hexokinase 1	Homo sapiens	61-64
10531306-3	1999	In one, G6P binds to the active site (the C-terminal half of HKI) and competes directly with ATP, whereas in the alternative suggestion the inhibitor binds to an allosteric site (the N-terminal half of HKI), which indirectly displaces ATP from the active site.	Glucose-6-Phosphate	8-11	hexokinase 1	Homo sapiens	202-205
10484363-20	1999	A top-down approach to metabolic control analysis was used to calculate the distributed control among glucose transport/phosphorylation [GLUT-4/hexokinase (HK)], glycogen synthesis, and glycolysis from the metabolic flux and G-6-P data.	Glucose-6-Phosphate	225-230	solute carrier family 2 member 4	Rattus norvegicus	137-154
10455119-0	1999	Glucose-6-phosphatase overexpression lowers glucose 6-phosphate and inhibits glycogen synthesis and glycolysis in hepatocytes without affecting glucokinase translocation.	Glucose-6-Phosphate	44-63	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	0-21
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	Glucose-6-Phosphate	99-118	glucokinase	Homo sapiens	15-26
10455129-4	1999	The experiment with 2-deoxyglucose suggests that glucose 6-phosphate, but not its further metabolism, is necessary for the induction of IGF transcript abundance in cultured fetal hepatocytes.	Glucose-6-Phosphate	49-68	insulin-like growth factor 1	Rattus norvegicus	136-139
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	Glucose-6-Phosphate	99-118	glucokinase	Homo sapiens	28-30
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	Glucose-6-Phosphate	99-118	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	36-57
10455119-2	1999	In hepatocytes glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase)(1) have converse effects on glucose 6-phosphate (and fructose 6-phosphate) levels.	Glucose-6-Phosphate	99-118	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	59-69
10421614-6	1999	DAK was extensively metabolized by rat liver microsomal monooxygenases at pH 8.8 in pyrophosphate buffer containing the glucose 6-phosphate NADPH-generating system to three metabolites as determined by HPLC.	Glucose-6-Phosphate	120-139	triokinase and FMN cyclase	Rattus norvegicus	0-3
10387081-1	1999	Hexokinase I governs the rate-limiting step of glycolysis in brain tissue, being inhibited by its product, glucose 6-phosphate, and allosterically relieved of product inhibition by phosphate.	Glucose-6-Phosphate	107-126	hexokinase 1	Homo sapiens	0-12
10387081-5	1999	Small-angle X-ray scattering data from the mutant hexokinase I in the presence of glucose/phosphate, glucose/glucose 6-phosphate, and glucose/ADP/Mg2+/AlF3 are consistent with a rodlike conformation for the monomer similar to that observed in crystal structures of the hexokinase I dimer.	Glucose-6-Phosphate	109-128	hexokinase 1	Homo sapiens	50-62
10318794-1	1999	Glycogen storage disease type 1b is caused by a deficiency in a glucose 6-phosphate transporter (G6PT) that translocates glucose 6-phosphate from the cytoplasm to the endoplasmic reticulum lumen where the active site of glucose 6-phosphatase is situated.	Glucose-6-Phosphate	64-83	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	97-101
10347146-2	1999	Studies of HKI indicate that the C-terminal half of the molecule is active and is sensitive to inhibition by glucose 6-phosphate (G6P), whereas the N-terminal half binds G6P but is devoid of catalytic activity.	Glucose-6-Phosphate	109-128	hexokinase 1	Homo sapiens	11-14
10347146-2	1999	Studies of HKI indicate that the C-terminal half of the molecule is active and is sensitive to inhibition by glucose 6-phosphate (G6P), whereas the N-terminal half binds G6P but is devoid of catalytic activity.	Glucose-6-Phosphate	130-133	hexokinase 1	Homo sapiens	11-14
10318794-1	1999	Glycogen storage disease type 1b is caused by a deficiency in a glucose 6-phosphate transporter (G6PT) that translocates glucose 6-phosphate from the cytoplasm to the endoplasmic reticulum lumen where the active site of glucose 6-phosphatase is situated.	Glucose-6-Phosphate	64-83	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	220-241
9895293-6	1999	The stimulation of flux through glucokinase by low concentrations of fructose decreased the proportion of glucose phosphorylated, which was cycled between glucose and glucose 6-phosphate, and increased the proportion that was glycolysed.	Glucose-6-Phosphate	167-186	glucokinase	Homo sapiens	32-43
10222010-5	1999	Here, we present a simple photometric assay that uses a cyclic detection system which, due to the sequential action of pyruvate kinase and hexokinase, results in an exponential increase of ADP and glucose 6-phosphate.	Glucose-6-Phosphate	197-216	hexokinase 1	Homo sapiens	139-149
10222010-6	1999	Glucose 6-phosphate is then revealed by a glucose-6-phosphate dehydrogenase reaction.	Glucose-6-Phosphate	0-19	glucose-6-phosphate dehydrogenase	Homo sapiens	42-75
10075811-0	1999	Mediated, amperometric biosensor for glucose-6-phosphate monitoring based on entrapped glucose-6-phosphate dehydrogenase, Mg2+ ions, tetracyanoquinodimethane, and nicotinamide adenine dinucleotide phosphate in carbon paste.	Glucose-6-Phosphate	37-56	glucose-6-phosphate dehydrogenase	Homo sapiens	87-120
10075811-0	1999	Mediated, amperometric biosensor for glucose-6-phosphate monitoring based on entrapped glucose-6-phosphate dehydrogenase, Mg2+ ions, tetracyanoquinodimethane, and nicotinamide adenine dinucleotide phosphate in carbon paste.	Glucose-6-Phosphate	37-56	mucin 7, secreted	Homo sapiens	122-125
10075811-1	1999	In this study, an amperometric carbon paste biosensor is developed for glucose-6-phosphate (G6P) monitoring which is based on entrapped Mg2+ ions, G6P dehydrogenase, NADP+ polyethylenimine (PEI) and the electroactive mediator, tetracyanoquinodimethane (TCNQ).	Glucose-6-Phosphate	71-90	mucin 7, secreted	Homo sapiens	136-139
10075811-1	1999	In this study, an amperometric carbon paste biosensor is developed for glucose-6-phosphate (G6P) monitoring which is based on entrapped Mg2+ ions, G6P dehydrogenase, NADP+ polyethylenimine (PEI) and the electroactive mediator, tetracyanoquinodimethane (TCNQ).	Glucose-6-Phosphate	92-95	mucin 7, secreted	Homo sapiens	136-139
10462451-1	1999	Mammalian hexokinases are believed to have evolved from a 100-kDa hexokinase which itself is a product of duplication and fusion of an ancestral gene encoding a 50-kDa glucose 6-phosphate-sensitive hexokinase.	Glucose-6-Phosphate	168-187	hexokinase 1	Homo sapiens	10-20
10462451-1	1999	Mammalian hexokinases are believed to have evolved from a 100-kDa hexokinase which itself is a product of duplication and fusion of an ancestral gene encoding a 50-kDa glucose 6-phosphate-sensitive hexokinase.	Glucose-6-Phosphate	168-187	hexokinase 1	Homo sapiens	66-76
10323254-3	1999	GSD 1b and GSD 1c are characterised by defective microsomal glucose-6-phosphate or pyrophosphate/phosphate transport, respectively.	Glucose-6-Phosphate	60-79	solute carrier family 37 member 4	Homo sapiens	0-6
10323254-3	1999	GSD 1b and GSD 1c are characterised by defective microsomal glucose-6-phosphate or pyrophosphate/phosphate transport, respectively.	Glucose-6-Phosphate	60-79	solute carrier family 37 member 4	Homo sapiens	11-17
10026167-1	1999	Glycogen storage disease type 1b (GSD-1b) is proposed to be caused by a deficiency in microsomal glucose 6-phosphate (G6P) transport, causing a loss of glucose-6-phosphatase activity and glucose homeostasis.	Glucose-6-Phosphate	118-121	solute carrier family 37 member 4	Homo sapiens	34-40
10026167-1	1999	Glycogen storage disease type 1b (GSD-1b) is proposed to be caused by a deficiency in microsomal glucose 6-phosphate (G6P) transport, causing a loss of glucose-6-phosphatase activity and glucose homeostasis.	Glucose-6-Phosphate	118-121	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	152-173
9895293-7	1999	The method described for maintaining the stimulation of glucose phosphorylation by isolated hepatocytes over prolonged incubation periods is especially suited to the further study of the control of glucokinase activity, in particular how the variation of flux through glucokinase affects the flux through all the pathways that utilize the product, glucose 6-phosphate.	Glucose-6-Phosphate	348-367	glucokinase	Homo sapiens	268-279
9886057-1	1999	In this work, it is shown that the Ca2+-transport ATPase found in the microsomal fraction of the cerebellum can use both glucose 6-phosphate/hexokinase and fructose 1,6-bisphosphate/phosphofructokinase as ATP-regenerating systems.	Glucose-6-Phosphate	121-140	hexokinase 1	Homo sapiens	141-151
9930626-1	1998	Liver glycogen synthase activity is increased, and glycogen phosphorylase activity and glucose 6-phosphate content reduced by in vivo insulin during a euglycemic hyperinsulinemic clamp in lean young adult rhesus monkeys.	Glucose-6-Phosphate	87-106	insulin	Macaca mulatta	134-141
9930626-5	1998	Insulin-stimulated minus basal bioactivity of the pH 2.0 insulin mediator was strongly inversely related to the insulin-stimulated minus basal glucose 6-phosphate content (r = -0.93, p < 0.0001).	Glucose-6-Phosphate	143-162	insulin	Macaca mulatta	0-7
9930626-5	1998	Insulin-stimulated minus basal bioactivity of the pH 2.0 insulin mediator was strongly inversely related to the insulin-stimulated minus basal glucose 6-phosphate content (r = -0.93, p < 0.0001).	Glucose-6-Phosphate	143-162	insulin	Macaca mulatta	57-64
9930626-5	1998	Insulin-stimulated minus basal bioactivity of the pH 2.0 insulin mediator was strongly inversely related to the insulin-stimulated minus basal glucose 6-phosphate content (r = -0.93, p < 0.0001).	Glucose-6-Phosphate	143-162	insulin	Macaca mulatta	112-119
9879670-3	1998	All the forms of HK showed the same affinity for glucose and MgATP and were also inhibited by glucose 6-phosphate (Glc 6-P) competitively vs. MgATP with similar Kis (28.5-37 microM).	Glucose-6-Phosphate	94-113	hexokinase 1	Homo sapiens	17-19
9879670-3	1998	All the forms of HK showed the same affinity for glucose and MgATP and were also inhibited by glucose 6-phosphate (Glc 6-P) competitively vs. MgATP with similar Kis (28.5-37 microM).	Glucose-6-Phosphate	115-122	hexokinase 1	Homo sapiens	17-19
9801136-4	1998	We suggest the hypothesis that insulin resistance is dependent on whether glucose is entering through GLUT1 or GLUT4 and on the two functional compartments of glucose 6-phosphate formation within the cell.	Glucose-6-Phosphate	159-178	insulin	Homo sapiens	31-38
9801136-6	1998	If glucose is entering through GLUT1 and phosphorylated by hexokinase I, the glucose 6-phosphate so formed is available for all metabolic pathways, including the hexosamine pathway.	Glucose-6-Phosphate	77-96	solute carrier family 2 member 1	Homo sapiens	31-36
9801136-6	1998	If glucose is entering through GLUT1 and phosphorylated by hexokinase I, the glucose 6-phosphate so formed is available for all metabolic pathways, including the hexosamine pathway.	Glucose-6-Phosphate	77-96	hexokinase 1	Homo sapiens	59-71
9725822-10	1998	Amylin inhibition of insulin-stimulated glucose transport in skeletal muscle was accompanied by a 433 +/- 72% increase in intracellular glucose 6-phosphate (G-6-P) despite the absence of extracellular glucose.	Glucose-6-Phosphate	136-155	islet amyloid polypeptide	Rattus norvegicus	0-6
9725822-10	1998	Amylin inhibition of insulin-stimulated glucose transport in skeletal muscle was accompanied by a 433 +/- 72% increase in intracellular glucose 6-phosphate (G-6-P) despite the absence of extracellular glucose.	Glucose-6-Phosphate	157-162	islet amyloid polypeptide	Rattus norvegicus	0-6
10073278-4	1999	Furthermore, using 31P NMR spectroscopy to measure intracellular glucose-6-phosphate, it has been shown that defects in insulin-stimulated glucose transport/phosphorylation activity are primarily responsible for the insulin resistance in these states.	Glucose-6-Phosphate	65-84	insulin	Homo sapiens	120-127
10073278-4	1999	Furthermore, using 31P NMR spectroscopy to measure intracellular glucose-6-phosphate, it has been shown that defects in insulin-stimulated glucose transport/phosphorylation activity are primarily responsible for the insulin resistance in these states.	Glucose-6-Phosphate	65-84	insulin	Homo sapiens	216-223
10442567-5	1999	Insulin-induced muscle hexokinase activity appears also to be attenuated in GH-deficient adults with raised intramuscular cellular glucose and normal-reduced concentrations of glucose-6-phosphate.	Glucose-6-Phosphate	176-195	insulin	Homo sapiens	0-7
9922708-6	1999	We found that mitochondria-bound hexokinase was more active than the cytosolic type in producing glucose 6-phosphate (G6P), probably due to the advantage in utilizing ATP produced in mitochondria.	Glucose-6-Phosphate	97-116	hexokinase 1	Homo sapiens	33-43
9922708-6	1999	We found that mitochondria-bound hexokinase was more active than the cytosolic type in producing glucose 6-phosphate (G6P), probably due to the advantage in utilizing ATP produced in mitochondria.	Glucose-6-Phosphate	118-121	hexokinase 1	Homo sapiens	33-43
9843733-8	1998	The observed values of these parameters may in fact explain an activation of GSa (G-6-P) and an inhibition of GPha (glucosei).	Glucose-6-Phosphate	82-87	GNAS complex locus	Homo sapiens	77-80
9781688-1	1998	Glycogen storage disease (GSD) 1b is the deficiency of endoplasmic reticulum glucose-6-phosphate (G6P) transport.	Glucose-6-Phosphate	98-101	solute carrier family 37 member 4	Homo sapiens	0-33
9648835-1	1998	Impaired muscle glucose phosphorylation to glucose-6-phosphate by hexokinases (HKs)-I and -II may contribute to insulin resistance in NIDDM and obesity.	Glucose-6-Phosphate	43-62	hexokinase 1	Homo sapiens	66-93
9787461-7	1998	Glucose 6-phosphate and glycine had little effect on the root-form PEPC at pH 7.3; they caused two-fold activation of the C4-form PEPC.	Glucose-6-Phosphate	0-19	MLO-like protein 4	Zea mays	130-134
9677378-0	1998	Identification of a phosphate regulatory site and a low affinity binding site for glucose 6-phosphate in the N-terminal half of human brain hexokinase.	Glucose-6-Phosphate	82-101	hexokinase 1	Homo sapiens	140-150
9677378-1	1998	Crystal structures of human hexokinase I reveal identical binding sites for phosphate and the 6-phosphoryl group of glucose 6-phosphate in proximity to Gly87, Ser88, Thr232, and Ser415, a binding site for the pyranose moiety of glucose 6-phosphate in proximity to Asp84, Asp413, and Ser449, and a single salt link involving Arg801 between the N- and C-terminal halves.	Glucose-6-Phosphate	116-135	hexokinase 1	Homo sapiens	28-40
9677378-1	1998	Crystal structures of human hexokinase I reveal identical binding sites for phosphate and the 6-phosphoryl group of glucose 6-phosphate in proximity to Gly87, Ser88, Thr232, and Ser415, a binding site for the pyranose moiety of glucose 6-phosphate in proximity to Asp84, Asp413, and Ser449, and a single salt link involving Arg801 between the N- and C-terminal halves.	Glucose-6-Phosphate	228-247	hexokinase 1	Homo sapiens	28-40
9726598-7	1998	The glucose 6-phosphate-dependent formation was entirely accounted for by a microsomal enzyme, glucose-6-phosphatase and was not due to a loss of latency of this enzyme.	Glucose-6-Phosphate	4-23	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	95-116
9648835-1	1998	Impaired muscle glucose phosphorylation to glucose-6-phosphate by hexokinases (HKs)-I and -II may contribute to insulin resistance in NIDDM and obesity.	Glucose-6-Phosphate	43-62	insulin	Homo sapiens	112-119
9696698-6	1998	Insulin also caused a reduction in liver glucose 6-phosphate (P = 0.05).	Glucose-6-Phosphate	41-60	insulin	Macaca mulatta	0-7
9699967-1	1998	The phosphorylation of glucose to glucose-6-phosphate, the first enzymatic step for glucose utilization is catalysed by a family of four hexokinase isoenzymes (HKI-IV) which display a tissue-specific distribution.	Glucose-6-Phosphate	34-53	hexokinase 1	Rattus norvegicus	160-163
9480890-4	1998	The Km values of G6PDH and 6PGDH for glucose 6-phosphate and for 6-phosphogluconate were 107.3 and 10.2 microM, respectively.	Glucose-6-Phosphate	37-56	glucose-6-phosphate dehydrogenase	Saccharomyces cerevisiae S288C	17-22
9589675-7	1998	Additionally, there was a sustained reduction in the insulin-stimulated skeletal muscle glycogen synthase fractional velocity (pretreatment: 0.29 +/- 0.03 vs. 24 months of rhGH: 0.24 +/- 0.03 vs. controls: 0.48 +/- 0.04; both P < 0.05 vs. controls), which was accompanied by a sustained 44% decrease in baseline glycogen content and a 70% increase in baseline im glucose concentrations in the presence of low-to-normal glucose 6-phosphate levels and persisting euglycemia.	Glucose-6-Phosphate	422-441	insulin	Homo sapiens	53-60
9508091-3	1998	The reducing equivalents needed for regeneration of GSH through the action of glutathione reductase (GRD) are provided by NADPH, produced by the action of glucose-6-phosphate dehydrogenase (G6P-DH) on substrates glucose-6-phosphate and NADP+.	Glucose-6-Phosphate	155-174	glutathione-disulfide reductase	Homo sapiens	78-99
9508091-3	1998	The reducing equivalents needed for regeneration of GSH through the action of glutathione reductase (GRD) are provided by NADPH, produced by the action of glucose-6-phosphate dehydrogenase (G6P-DH) on substrates glucose-6-phosphate and NADP+.	Glucose-6-Phosphate	155-174	glutathione-disulfide reductase	Homo sapiens	101-104
9508091-3	1998	The reducing equivalents needed for regeneration of GSH through the action of glutathione reductase (GRD) are provided by NADPH, produced by the action of glucose-6-phosphate dehydrogenase (G6P-DH) on substrates glucose-6-phosphate and NADP+.	Glucose-6-Phosphate	155-174	2,4-dienoyl-CoA reductase 1	Homo sapiens	122-127
9508091-3	1998	The reducing equivalents needed for regeneration of GSH through the action of glutathione reductase (GRD) are provided by NADPH, produced by the action of glucose-6-phosphate dehydrogenase (G6P-DH) on substrates glucose-6-phosphate and NADP+.	Glucose-6-Phosphate	155-174	glucose-6-phosphate dehydrogenase	Homo sapiens	190-196
9497346-8	1998	Binding to the high affinity site was competitively blocked by Glc-6-P (Ki = 9 microM), whereas binding was unaffected by mannose-6-phosphate, Pi, and PPi and only modestly depressed by 2-deoxy-D-glucose 6-phosphate, a poor substrate for Glc-6-Pase in intact microsomes.	Glucose-6-Phosphate	63-70	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	238-248
9684361-12	1998	Little inhibition was observed with glucose 6-phosphate (up to 15 mM) at pH 8.0; however, at pH 7.0 glucokinase activity was inhibited 30-50% by physiological concentrations of glucose 6-phosphate.	Glucose-6-Phosphate	177-196	glucokinase	Homo sapiens	100-111
9627357-2	1998	The difference between the rates of hydrolysis of glucose-6-P and glycerol-P was taken as the measure of glucose-6-phosphatase activity.	Glucose-6-Phosphate	50-61	glucose-6-phosphatase, catalytic	Mus musculus	105-126
9571158-6	1998	After insulin stimulation, the intramuscular content of glucose 6-phosphate, which regulates glycogen synthesis in skeletal muscle, was significantly decreased in OLETF rats (P < 0.01).	Glucose-6-Phosphate	56-75	insulin	Homo sapiens	6-13
9497346-0	1998	Direct evidence for the involvement of two glucose 6-phosphate-binding sites in the glucose-6-phosphatase activity of intact liver microsomes.	Glucose-6-Phosphate	43-62	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	84-105
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	Glucose-6-Phosphate	64-83	glutathione S-transferase kappa 1	Homo sapiens	4-7
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	Glucose-6-Phosphate	64-83	glucose-6-phosphate isomerase	Homo sapiens	8-11
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	Glucose-6-Phosphate	85-88	glutathione S-transferase kappa 1	Homo sapiens	4-7
9616041-2	1998	The GST-GPI fusion protein showed affinities for the substrates glucose 6-phosphate (G6P) and fructose 6-phosphate (F6P) similar to those of the native enzyme purified from human red blood cells (RBC).	Glucose-6-Phosphate	85-88	glucose-6-phosphate isomerase	Homo sapiens	8-11
9519744-2	1998	It has been suggested that impaired glucose phosphorylation to glucose-6-phosphate, catalyzed in muscle by hexokinase (HK)II, may contribute to this insulin resistance.	Glucose-6-Phosphate	63-82	hexokinase 1	Homo sapiens	107-117
9519744-2	1998	It has been suggested that impaired glucose phosphorylation to glucose-6-phosphate, catalyzed in muscle by hexokinase (HK)II, may contribute to this insulin resistance.	Glucose-6-Phosphate	63-82	hexokinase 2	Homo sapiens	119-124
9519744-2	1998	It has been suggested that impaired glucose phosphorylation to glucose-6-phosphate, catalyzed in muscle by hexokinase (HK)II, may contribute to this insulin resistance.	Glucose-6-Phosphate	63-82	insulin	Homo sapiens	149-156
9422720-8	1998	Gly862 --> Ala and Gly534 --> Ala are the first instances of single residue mutations in hexokinase I that affect the binding affinity of ATP and abolish phosphate-induced relief of glucose 6-phosphate inhibition, respectively.	Glucose-6-Phosphate	188-207	hexokinase 1	Homo sapiens	95-107
9486162-2	1998	Exercise also increases insulin-stimulated glucose 6-phosphate in skeletal muscle, suggesting that exercise increases hexokinase activity.	Glucose-6-Phosphate	43-62	insulin	Homo sapiens	24-31
9493266-0	1998	The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.	Glucose-6-Phosphate	148-167	hexokinase 1	Homo sapiens	31-41
9493266-0	1998	The mechanism of regulation of hexokinase: new insights from the crystal structure of recombinant human brain hexokinase complexed with glucose and glucose-6-phosphate.	Glucose-6-Phosphate	148-167	hexokinase 1	Homo sapiens	110-120
9493266-5	1998	RESULTS: The complex of human hexokinase I with glucose and Gluc-6-P (determined to 2.8 A resolution) is a dimer with twofold molecular symmetry.	Glucose-6-Phosphate	60-68	hexokinase 1	Homo sapiens	30-42
9493266-11	1998	CONCLUSIONS: The binding synergism of glucose and Gluc-6-P probably arises out of the mutual stabilization of a common (glucose-bound) conformation of hexokinase I.	Glucose-6-Phosphate	50-58	hexokinase 1	Homo sapiens	151-163
9458741-5	1998	Amylin increased intracellular glucose 6-phosphate (G-6-P), and G-6-P was negatively correlated with 2-deoxyglucose uptake in both FO (r = -0.65; P < 0.01) and FG (r = -0.53; P < 0.01) muscle.	Glucose-6-Phosphate	31-50	islet amyloid polypeptide	Rattus norvegicus	0-6
9417069-7	1998	Importantly, inhibition of glucokinase activity by glucosamine infusion blunted both the stimulation of Glc-6-Pase and the inhibition of PEPCK gene expression by Glc, suggesting that an intrahepatic signal (metabolite) generated by the metabolism of glucose at or beyond Glc-6-P was responsible for the regulatory effect of Glc.	Glucose-6-Phosphate	104-111	glucokinase	Rattus norvegicus	27-38
9871795-3	1998	Working with the L-type pyruvate kinase gene we have found that in hepatocytes glucose-dependent gene regulation requires: Presence of the GLUT2 glucose transporter, necessary to allow for an effective depletion in glucose 6-phosphate (G-6P) under gluconeogenic conditions.	Glucose-6-Phosphate	215-234	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	139-144
9925924-0	1998	Assignment1 of glucose 6-phosphate translocase (G6PT1) to human chromosome band 11q23.3 by in situ hybridization.	Glucose-6-Phosphate	15-34	solute carrier family 37 member 4	Homo sapiens	48-53
9452958-1	1998	Mammalian hexokinase types one and three (HK1 and HK3) are 100 kDa isozymes that phosphorylate glucose to glucose-6-phosphate.	Glucose-6-Phosphate	106-125	hexokinase 1	Rattus norvegicus	42-45
9452958-1	1998	Mammalian hexokinase types one and three (HK1 and HK3) are 100 kDa isozymes that phosphorylate glucose to glucose-6-phosphate.	Glucose-6-Phosphate	106-125	hexokinase 3	Rattus norvegicus	50-53
10212841-0	1998	Insulin unexpectedly increases the glucose 6-phosphate Ka of skeletal muscle glycogen synthase in calorie-restricted monkeys.	Glucose-6-Phosphate	35-54	insulin	Macaca mulatta	0-7
10212841-1	1998	In skeletal muscle of normal subjects, the concentration of glucose 6-phosphate (G6P) at which the activity of glycogen synthase (GS) is half maximal (Ka) is decreased by in vivo insulin, and the fractional activity is increased without a change in GS maximal activity (Vmax).	Glucose-6-Phosphate	60-79	insulin	Macaca mulatta	179-186
10212841-1	1998	In skeletal muscle of normal subjects, the concentration of glucose 6-phosphate (G6P) at which the activity of glycogen synthase (GS) is half maximal (Ka) is decreased by in vivo insulin, and the fractional activity is increased without a change in GS maximal activity (Vmax).	Glucose-6-Phosphate	81-84	insulin	Macaca mulatta	179-186
9435446-3	1998	In contrast, liver microsomal transport of G6P and phosphate was deficient in the GSD 1b and 1c patients, respectively.	Glucose-6-Phosphate	43-46	solute carrier family 37 member 4	Homo sapiens	82-88
9435447-1	1998	The phosphorylation of glucose to glucose-6-phosphate, catalyzed by hexokinase, is the first committed step in glucose uptake into skeletal muscle.	Glucose-6-Phosphate	34-53	hexokinase 1	Homo sapiens	68-78
9540854-9	1997	Slower inactivation was observed when GAP-DH was incubated with fructose, glucose 6-phosphate or potassium cyanate.	Glucose-6-Phosphate	74-93	LOC786101	Bos taurus	38-44
9384557-7	1997	W1807 binds at the GPb allosteric effector site, the site which binds AMP, glucose-6-phosphate and a number of other phosphorylated ligands, and induces conformational changes that are characteristic of those observed with the naturally occurring allosteric inhibitor, glucose-6-phosphate.	Glucose-6-Phosphate	75-94	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	19-22
9384557-7	1997	W1807 binds at the GPb allosteric effector site, the site which binds AMP, glucose-6-phosphate and a number of other phosphorylated ligands, and induces conformational changes that are characteristic of those observed with the naturally occurring allosteric inhibitor, glucose-6-phosphate.	Glucose-6-Phosphate	269-288	LOW QUALITY PROTEIN: glycogen phosphorylase, brain form	Oryctolagus cuniculus	19-22
9395079-1	1997	We previously demonstrated that, in hepatocytes in primary culture, the role of insulin on induction of L-type pyruvate kinase (L-PK) gene expression was mainly to induce glucokinase synthesis, needed for glucose phosphorylation to glucose 6-phosphate.	Glucose-6-Phosphate	232-251	pyruvate kinase L/R	Rattus norvegicus	104-126
9395079-1	1997	We previously demonstrated that, in hepatocytes in primary culture, the role of insulin on induction of L-type pyruvate kinase (L-PK) gene expression was mainly to induce glucokinase synthesis, needed for glucose phosphorylation to glucose 6-phosphate.	Glucose-6-Phosphate	232-251	pyruvate kinase L/R	Rattus norvegicus	128-132
9477574-9	1998	Expression of the coding region of the GPT in transformed yeast cells and subsequent transport experiments with the purified protein demonstrated that the GPT protein mediates a 1:1 exchange of glucose 6-phosphate mainly with inorganic phosphate and triose phosphates.	Glucose-6-Phosphate	194-213	glucose-6-phosphate/phosphate-translocator precursor	Zea mays	39-42
9477574-9	1998	Expression of the coding region of the GPT in transformed yeast cells and subsequent transport experiments with the purified protein demonstrated that the GPT protein mediates a 1:1 exchange of glucose 6-phosphate mainly with inorganic phosphate and triose phosphates.	Glucose-6-Phosphate	194-213	glucose-6-phosphate/phosphate-translocator precursor	Zea mays	155-158
9477574-10	1998	Glucose 6-phosphate imported via the GPT can thus be used either for starch biosynthesis, during which process inorganic phosphate is released, or as a substrate for the oxidative pentose phosphate pathway, yielding triose phosphates.	Glucose-6-Phosphate	0-19	glucose-6-phosphate/phosphate-translocator precursor	Zea mays	37-40
9371733-11	1997	The Glc-6-P stimulation of the GPa phosphatase activity of PP1 was negated by 1-GlcNAc-6-P but there was no inhibition of the basal rate in the absence of Glc-6-P.	Glucose-6-Phosphate	4-11	inorganic pyrophosphatase 1	Homo sapiens	59-62
9371733-11	1997	The Glc-6-P stimulation of the GPa phosphatase activity of PP1 was negated by 1-GlcNAc-6-P but there was no inhibition of the basal rate in the absence of Glc-6-P.	Glucose-6-Phosphate	155-162	inorganic pyrophosphatase 1	Homo sapiens	59-62
9389415-5	1997	One of the characteristic features of pseudohypoxia due to hyperglycaemia is an increase in the ratio of NADH/NAD+, so in the present study the changes in NADH - induced glucose 6-phosphatase activity were investigated as related to the release of inorganic phosphate (Pi) derived from glucose 6-phosphate.	Glucose-6-Phosphate	286-305	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	170-191
9458741-5	1998	Amylin increased intracellular glucose 6-phosphate (G-6-P), and G-6-P was negatively correlated with 2-deoxyglucose uptake in both FO (r = -0.65; P < 0.01) and FG (r = -0.53; P < 0.01) muscle.	Glucose-6-Phosphate	52-57	islet amyloid polypeptide	Rattus norvegicus	0-6