PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2768222-6	1989	We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4.	Leukotriene D4	257-271	dipeptidase 1	Homo sapiens	52-55
2768222-6	1989	We also examined the substrate specificity of human MDP and found that human MDP catalyzed the hydrolysis of S(substituent)-L-cysteinyl-glycine adducts such as L-cystinyl-bis(glycine) and S-N-ethylmaleimide-L-cysteinyl-glycine, as well as the conversion of leukotriene D4 to leukotriene E4.	Leukotriene D4	257-271	dipeptidase 1	Homo sapiens	77-80
2564341-16	1989	The phospholipase A2 inhibitor, bromophenacyl bromide, but not the cyclooxygenase inhibitor, indomethacin, at a concentration of 20 microM reduced the metabolic and hemodynamic effects of 5 mM leukotriene D4.	Leukotriene D4	193-207	phospholipase A2 group IB	Rattus norvegicus	4-20
2758374-7	1989	The attenuation of LTD4-induced contraction by PAF was also prevented by pretreatment with indomethacin or with the thromboxane synthase inhibitor U63,557A, but not by pretreatment with the lipoxygenase inhibitors BW755c or nordihydroguaiaretic acid.	Leukotriene D4	19-23	thromboxane-A synthase	Cavia porcellus	116-136
2465008-7	1989	We conclude from our results that tumor necrosis factor alpha is likely to act as a final mediator of endotoxin action in a sequence of events which includes formation of leukotriene D4 and reactive oxygen species.	Leukotriene D4	171-185	tumor necrosis factor	Mus musculus	34-61
2463771-0	1989	Leukotriene D4 inhibits atrial natriuretic factor-dependent cGMP production in rat glomerulus.	Leukotriene D4	0-14	natriuretic peptide A	Rattus norvegicus	24-49
2463771-1	1989	The effects of leukotriene D4 (LTD4) on guanosine 3",5"-cyclic monophosphate (cGMP) production induced by atrial natriuretic factor (ANF) or sodium nitroprusside (SNP) were investigated in isolated rat glomeruli.	Leukotriene D4	15-29	natriuretic peptide A	Rattus norvegicus	106-131
2844265-14	1988	The conversion of leukotriene D4 to leukotriene E4 in the presence of human renal dipeptidase was demonstrated by HPLC procedures.	Leukotriene D4	18-32	dipeptidase 1	Homo sapiens	76-93
2629896-7	1989	However, de-endothelialization of rat thoracic aortic rings or treatment of aortic rings with the 5-lipoxygenase inhibitor nordihydroguaiaretic acid abolished the relaxant effect of LTD4.	Leukotriene D4	182-186	arachidonate 5-lipoxygenase	Rattus norvegicus	98-112
2845060-0	1988	Leukotriene D4-induced homologous desensitization in basal and differentiated U-937 cells: characterization with the partial agonist leukotriene E4 and assessment of receptor reserve.	Leukotriene D4	0-14	ubiquitination factor E4A	Homo sapiens	145-174
2836315-0	1988	Effect of a novel leukotriene D4 antagonist with 5-lipoxygenase and cyclooxygenase inhibitory activity, Wy-45,911, on leukotriene-D4-and antigen-induced bronchoconstriction in the guinea pig.	Leukotriene D4	18-32	arachidonate 5-lipoxygenase	Rattus norvegicus	49-63
2837395-3	1988	When RBL-1 cells were treated with LTD4, a small, transient decrease in PKC activity in cytosolic fraction was observed within 7.5 s after LTD4 treatment.	Leukotriene D4	35-39	RB transcriptional corepressor like 1	Rattus norvegicus	5-10
2837395-3	1988	When RBL-1 cells were treated with LTD4, a small, transient decrease in PKC activity in cytosolic fraction was observed within 7.5 s after LTD4 treatment.	Leukotriene D4	139-143	RB transcriptional corepressor like 1	Rattus norvegicus	5-10
2581089-3	1985	Thyrotropin-releasing hormone (TRH), a tripeptide, has potent antihypotensive activity in experimental shock, including that resulting from either leukotriene D4 administration or antigen-induced anaphylaxis.	Leukotriene D4	147-161	thyrotropin releasing hormone	Cavia porcellus	0-29
2444781-6	1987	ANF also relaxed feline coronary helical strips when contracted by U-46,619 (an endoperoxide analog), serotonin, and leukotriene D4.	Leukotriene D4	117-131	natriuretic peptide A	Homo sapiens	0-3
3094005-0	1986	Islet-activating protein inhibits leukotriene D4- and leukotriene C4- but not bradykinin- or calcium ionophore-induced prostacyclin synthesis in bovine endothelial cells.	Leukotriene D4	34-48	CD47 molecule	Bos taurus	0-24
3733728-0	1986	Leukotriene D4 treatment of bovine aortic endothelial cells and murine smooth muscle cells in culture results in an increase in phospholipase A2 activity.	Leukotriene D4	0-14	phospholipase A2, group IB, pancreas	Mus musculus	128-144
3733728-3	1986	Leukotriene D4 treatment resulted in a dose-dependent, stereospecific increase in phospholipase A2 activity with phosphatidylcholine as a substrate.	Leukotriene D4	0-14	phospholipase A2, group IB, pancreas	Mus musculus	82-98
3733728-7	1986	We conclude that the increase in prostanoid synthesis observed after leukotriene D4 treatment is a result of an increase in a phospholipase A2 activity.	Leukotriene D4	69-83	phospholipase A2, group IB, pancreas	Mus musculus	126-142
4000427-7	1985	In addition, motilin attenuated pressor responses to vasopressin, leukotriene D4, and the pressor effect evoked by complete spinal cord stimulation.	Leukotriene D4	66-80	motilin	Rattus norvegicus	13-20
3567464-5	1987	The conversion of LTD4 to LTE4 is inhibited by the aminopeptidase inhibitor, L-cysteine (10 mM).	Leukotriene D4	18-22	alanyl aminopeptidase, membrane	Sus scrofa	51-65
3103170-2	1986	Leukotriene D4 increased the release of arachidonic acid primarily by activating phospholipase A2 while bradykinin activated the phospholipase C pathway.	Leukotriene D4	0-14	LOC104974671	Bos taurus	81-97
3094005-2	1986	Pretreatment of these cells with the pertussis toxin islet-activating protein (IAP) results in a dose-dependent inhibition of the release of arachidonic acid metabolites and prostacyclin in response to leukotriene D4 and leukotriene C4.	Leukotriene D4	202-216	CD47 molecule	Bos taurus	53-77
3094005-2	1986	Pretreatment of these cells with the pertussis toxin islet-activating protein (IAP) results in a dose-dependent inhibition of the release of arachidonic acid metabolites and prostacyclin in response to leukotriene D4 and leukotriene C4.	Leukotriene D4	202-216	CD47 molecule	Bos taurus	79-82
3094005-6	1986	These results suggest that the 41-kDa IAP substrate, presumably a guanine nucleotide regulatory protein, mediates the response of CPAE cells to leukotriene D4 and leukotriene C4, but not to bradykinin or the calcium ionophore.	Leukotriene D4	144-158	CD47 molecule	Bos taurus	38-41
2872925-4	1986	Verification of leukotriene C4 formation was obtained by conversion into leukotriene D4 during reaction of the HPLC-purified platelet-derived leukotriene C4 with commercial gamma-glutamyl transpeptidase.	Leukotriene D4	73-87	inactive glutathione hydrolase 2	Homo sapiens	173-202
3514848-3	1986	Contraction of tracheal strips with leukotriene D4 was accompanied by a 3-fold increase in cyclic GMP accumulation.	Leukotriene D4	36-50	5'-nucleotidase, cytosolic II	Homo sapiens	98-101
3863619-1	1985	The metabolism of leukotriene D4 to leukotriene E4 by a dipeptidase of kidney tissue is strongly inhibited by cilastatin (MK 0791) a known renal dehydropeptidase-I inhibitor.	Leukotriene D4	18-32	dipeptidase 1	Homo sapiens	145-163
2581089-3	1985	Thyrotropin-releasing hormone (TRH), a tripeptide, has potent antihypotensive activity in experimental shock, including that resulting from either leukotriene D4 administration or antigen-induced anaphylaxis.	Leukotriene D4	147-161	thyrotropin releasing hormone	Cavia porcellus	31-34
3159229-0	1985	Leukotriene D4 reduces pressor responses to sympathetic stimulation, angiotensin, and vasopressin.	Leukotriene D4	0-14	arginine vasopressin	Homo sapiens	86-97
6443153-1	1984	Thyrotropin-releasing hormone (TRH) reversed the hypotension produced by leukotriene D4 (LTD4) (5 micrograms/kg, i.v.)	Leukotriene D4	73-87	thyrotropin releasing hormone	Cavia porcellus	0-29
3972459-4	1985	The two calmodulin inhibitors effected relaxation of contraction of guinea-pig trachea induced by histamine and leukotriene D4 (LTD4).	Leukotriene D4	112-126	calmodulin-3	Cavia porcellus	8-18
3972459-4	1985	The two calmodulin inhibitors effected relaxation of contraction of guinea-pig trachea induced by histamine and leukotriene D4 (LTD4).	Leukotriene D4	128-132	calmodulin-3	Cavia porcellus	8-18
6442855-0	1984	[The effect of thyrotropin releasing hormone on the peripheral airway response induced by leukotriene D].	Leukotriene D4	90-103	thyrotropin releasing hormone	Homo sapiens	15-44
6151716-5	1984	The membrane fraction contained the enzymes gamma-glutamyl transpeptidase and amino peptidase which convert LTC4 to LTD4 and LTD4 to LTE4, respectively.	Leukotriene D4	116-120	gamma-glutamyltransferase 1	Rattus norvegicus	44-73
6443153-1	1984	Thyrotropin-releasing hormone (TRH) reversed the hypotension produced by leukotriene D4 (LTD4) (5 micrograms/kg, i.v.)	Leukotriene D4	73-87	thyrotropin releasing hormone	Cavia porcellus	31-34
6443153-1	1984	Thyrotropin-releasing hormone (TRH) reversed the hypotension produced by leukotriene D4 (LTD4) (5 micrograms/kg, i.v.)	Leukotriene D4	89-93	thyrotropin releasing hormone	Cavia porcellus	0-29
6443153-1	1984	Thyrotropin-releasing hormone (TRH) reversed the hypotension produced by leukotriene D4 (LTD4) (5 micrograms/kg, i.v.)	Leukotriene D4	89-93	thyrotropin releasing hormone	Cavia porcellus	31-34
6405395-0	1983	Thyrotropin-releasing hormone reverses the hypotension and bradycardia produced by leukotriene D4 in unanesthetized guinea pigs.	Leukotriene D4	83-97	thyrotropin releasing hormone	Cavia porcellus	0-29
6491978-0	1984	Leukotriene D4 inhibits cardiovascular responses to sympathetic stimulation, angiotensin and vasopressin in the pithed spontaneously hypertensive rats.	Leukotriene D4	0-14	arginine vasopressin	Rattus norvegicus	93-104
6422508-0	1983	Leukotriene D4-induced hypotension is reversed by thyrotropin-releasing hormone.	Leukotriene D4	0-14	thyrotropin releasing hormone	Rattus norvegicus	50-79
6122208-0	1982	Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids.	Leukotriene D4	110-124	inactive glutathione hydrolase 2	Homo sapiens	54-83
6122208-3	1982	Because gamma-glutamyl transpeptidase is bound to the external surface of cell membranes and thus is readily accessible to plasma amino acids, it appears that conversion of leukotriene C4 to leukotriene D4 under physiological conditions is coupled with the formation of gamma-glutamyl amino acids.	Leukotriene D4	191-205	inactive glutathione hydrolase 2	Homo sapiens	8-37
30226562-7	2018	GPR17 knockdown also attenuated cell injury induced by the agonist leukotriene D4 (LTD4) or uridine 5"-diphosphate (UDP) in neuron-glial mixed cultures.	Leukotriene D4	67-81	G protein-coupled receptor 17	Homo sapiens	0-5
6122208-5	1982	Conversion of leukotriene D4 to leukotriene C4 is effectively catalyzed by gamma-glutamyl transpeptidase in the presence of relatively low concentrations of glutathione.	Leukotriene D4	14-28	inactive glutathione hydrolase 2	Homo sapiens	75-104
33136175-7	2021	RESULTS: The human primary small airway epithelial cells (SAECs) treated with LTD4 showed significant alterations in the levels of inflammatory markers such as GM-CSF, TNF-alpha, IL-1beta, EGF and eotaxin in dose- and time-dependent manner.	Leukotriene D4	78-82	colony stimulating factor 2	Homo sapiens	160-166
33136175-7	2021	RESULTS: The human primary small airway epithelial cells (SAECs) treated with LTD4 showed significant alterations in the levels of inflammatory markers such as GM-CSF, TNF-alpha, IL-1beta, EGF and eotaxin in dose- and time-dependent manner.	Leukotriene D4	78-82	tumor necrosis factor	Homo sapiens	168-177
33136175-7	2021	RESULTS: The human primary small airway epithelial cells (SAECs) treated with LTD4 showed significant alterations in the levels of inflammatory markers such as GM-CSF, TNF-alpha, IL-1beta, EGF and eotaxin in dose- and time-dependent manner.	Leukotriene D4	78-82	interleukin 1 alpha	Homo sapiens	179-187
33136175-7	2021	RESULTS: The human primary small airway epithelial cells (SAECs) treated with LTD4 showed significant alterations in the levels of inflammatory markers such as GM-CSF, TNF-alpha, IL-1beta, EGF and eotaxin in dose- and time-dependent manner.	Leukotriene D4	78-82	C-C motif chemokine ligand 11	Homo sapiens	197-204
33136175-9	2021	LTD4 also enhanced inflammation by increasing the expression of COX-2 in SAECs.	Leukotriene D4	0-4	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
33136175-12	2021	CONCLUSION: The results suggest that LTD4 could induce inflammatory response in human airway epithelial cell by activating NALP3 inflammasome.	Leukotriene D4	37-41	NLR family pyrin domain containing 3	Homo sapiens	123-128
32802190-11	2020	Ethanol and SWELL1 elevated the levels of PGE2 or LTD4 in the liver of mice and cell lines.	Leukotriene D4	50-54	leucine rich repeat containing 8 VRAC subunit A	Homo sapiens	12-18
30389631-2	2019	5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4).	Leukotriene D4	142-156	arachidonate 5-lipoxygenase	Homo sapiens	0-5
30389631-2	2019	5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4).	Leukotriene D4	142-156	arachidonate 5-lipoxygenase activating protein	Homo sapiens	64-68
30389631-2	2019	5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4).	Leukotriene D4	158-162	arachidonate 5-lipoxygenase	Homo sapiens	0-5
30389631-2	2019	5-LOX is activated by enzyme 5-Lipoxygenase-activating protein (FLAP), which further lead to production of cysLTs i.e. leukotriene C4 (LTC4), leukotriene D4 (LTD4) and leukotriene E4 (LTE4).	Leukotriene D4	158-162	arachidonate 5-lipoxygenase activating protein	Homo sapiens	64-68
6106018-4	1980	The results demonstrate that gamma-glutamyl transpeptidase is involved in the biosynthesis of leukotriene D4 and suggest that leukotriene C4 is formed as an intermediate.	Leukotriene D4	94-108	gamma-glutamyltransferase 1	Rattus norvegicus	29-58
33285161-4	2021	OBJECTIVE: We sought to determine whether LTD4 functionally antagonize LTC4 signaling at CysLT2R.	Leukotriene D4	42-46	cysteinyl leukotriene receptor 2	Mus musculus	89-96
33285161-8	2021	Inhaled LTD4 blocked LTC4-mediated, potentiation of ovalbumin (OVA)-induced eosinophilic inflammation, recruitment of platelet-adherent eosinophils, and increases in IL-33, IL-4, IL-5, and IL-13 in the lung tissue.	Leukotriene D4	8-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	52-61
33285161-8	2021	Inhaled LTD4 blocked LTC4-mediated, potentiation of ovalbumin (OVA)-induced eosinophilic inflammation, recruitment of platelet-adherent eosinophils, and increases in IL-33, IL-4, IL-5, and IL-13 in the lung tissue.	Leukotriene D4	8-12	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	63-66
33285161-8	2021	Inhaled LTD4 blocked LTC4-mediated, potentiation of ovalbumin (OVA)-induced eosinophilic inflammation, recruitment of platelet-adherent eosinophils, and increases in IL-33, IL-4, IL-5, and IL-13 in the lung tissue.	Leukotriene D4	8-12	interleukin 33	Mus musculus	166-171
33285161-8	2021	Inhaled LTD4 blocked LTC4-mediated, potentiation of ovalbumin (OVA)-induced eosinophilic inflammation, recruitment of platelet-adherent eosinophils, and increases in IL-33, IL-4, IL-5, and IL-13 in the lung tissue.	Leukotriene D4	8-12	interleukin 4	Mus musculus	173-177
33285161-8	2021	Inhaled LTD4 blocked LTC4-mediated, potentiation of ovalbumin (OVA)-induced eosinophilic inflammation, recruitment of platelet-adherent eosinophils, and increases in IL-33, IL-4, IL-5, and IL-13 in the lung tissue.	Leukotriene D4	8-12	interleukin 5	Mus musculus	179-183
33285161-8	2021	Inhaled LTD4 blocked LTC4-mediated, potentiation of ovalbumin (OVA)-induced eosinophilic inflammation, recruitment of platelet-adherent eosinophils, and increases in IL-33, IL-4, IL-5, and IL-13 in the lung tissue.	Leukotriene D4	8-12	interleukin 13	Mus musculus	189-194
32325220-7	2020	However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine).	Leukotriene D4	428-442	dipeptidase 3	Homo sapiens	9-14
32325220-7	2020	However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine).	Leukotriene D4	428-442	dipeptidase 1	Homo sapiens	29-34
32325220-7	2020	However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine).	Leukotriene D4	428-442	dipeptidase 2	Homo sapiens	39-44
30867226-0	2019	Role of Protein Tyrosine Phosphatase Epsilon (PTPepsilon) in Leukotriene D4-Induced CXCL8 Expression.	Leukotriene D4	61-75	C-X-C motif chemokine ligand 8	Homo sapiens	84-89
30226562-7	2018	GPR17 knockdown also attenuated cell injury induced by the agonist leukotriene D4 (LTD4) or uridine 5"-diphosphate (UDP) in neuron-glial mixed cultures.	Leukotriene D4	83-87	G protein-coupled receptor 17	Homo sapiens	0-5
29751150-0	2018	Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway.	Leukotriene D4	15-29	epidermal growth factor receptor	Homo sapiens	84-88
30693690-7	2018	Compared with hypoxia without any treatment, pretreatment with GPR17 agonists (LTD4, UDP, UDP-G) significantly reduced cell viability (the survival rates of cells decreased by 29.6%, 31.8% and 33.9%, all P<0.01), while the effect of GPR17 antagonist (cangrelor) was the opposite (the survival rates of cells increased by 33.2%, P<0.01).	Leukotriene D4	79-83	G protein-coupled receptor 17	Mus musculus	63-68
30693690-7	2018	Compared with hypoxia without any treatment, pretreatment with GPR17 agonists (LTD4, UDP, UDP-G) significantly reduced cell viability (the survival rates of cells decreased by 29.6%, 31.8% and 33.9%, all P<0.01), while the effect of GPR17 antagonist (cangrelor) was the opposite (the survival rates of cells increased by 33.2%, P<0.01).	Leukotriene D4	79-83	G protein-coupled receptor 17	Mus musculus	236-241
29751150-0	2018	Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway.	Leukotriene D4	15-29	mitogen-activated protein kinase 3	Homo sapiens	89-95
29264420-0	2017	Leukotriene D4 induces chemotaxis in human eosinophilc cell line, EoL-1 cells via CysLT1 receptor activation.	Leukotriene D4	0-14	cysteinyl leukotriene receptor 1	Homo sapiens	82-88
28754608-8	2018	RESULTS: Inflammatory mediators, such as 5-hydroxytryptamin, histamine, U46619, and leukotriene D4, are capable of inducing Ca2+-activated Cl- currents in ASM cells, and these currents are mediated by TMEM16A.	Leukotriene D4	84-98	anoctamin 1, calcium activated chloride channel	Mus musculus	201-208
27647044-10	2017	In vitro stimulation with leukotriene D4 increased iNOS mRNA levels and NO production in cultured BAL macrophages.	Leukotriene D4	26-40	nitric oxide synthase 2	Homo sapiens	51-55
27388564-13	2016	In addition, increased mRNA expression of IL-1beta, IL-6 and IL-10 were detected in tumors from mice that had been treated with LTD4 or PGE2.	Leukotriene D4	128-132	interleukin 1 beta	Mus musculus	42-50
27863043-1	2016	The GPR17 receptor is a G protein-coupled receptor (GPCR) that seems to respond to two unrelated families of endogenous ligands: nucleotide sugars (UDP, UDP-galactose, and UDP-glucose) and cysteinyl leukotrienes (LTD4 , LTC4 , and LTE4 ), with significant affinity at micromolar and nanomolar concentrations, respectively.	Leukotriene D4	213-217	G protein-coupled receptor 17	Homo sapiens	4-9
26883724-6	2016	Leukotriene D4 was sufficient to stimulate IL-4 secretion by ILC2s, and the supernatant from activated ILC2s could potently drive TH2 differentiation in vitro in an IL-4-dependent manner.	Leukotriene D4	0-14	interleukin 4	Rattus norvegicus	43-47
26883724-6	2016	Leukotriene D4 was sufficient to stimulate IL-4 secretion by ILC2s, and the supernatant from activated ILC2s could potently drive TH2 differentiation in vitro in an IL-4-dependent manner.	Leukotriene D4	0-14	interleukin 4	Rattus norvegicus	165-169
27830016-1	2016	PURPOSE: This study aims to determine whether leukotriene D4 (LTD4) can promote T cell proliferation in adenoid tissues via activation of CysLT1 receptors in children with OSAS.	Leukotriene D4	46-60	cysteinyl leukotriene receptor 1	Homo sapiens	138-144
27388564-13	2016	In addition, increased mRNA expression of IL-1beta, IL-6 and IL-10 were detected in tumors from mice that had been treated with LTD4 or PGE2.	Leukotriene D4	128-132	interleukin 6	Mus musculus	52-56
27388564-13	2016	In addition, increased mRNA expression of IL-1beta, IL-6 and IL-10 were detected in tumors from mice that had been treated with LTD4 or PGE2.	Leukotriene D4	128-132	interleukin 10	Mus musculus	61-66
26255103-0	2016	Leukotriene D4 and prostaglandin E2 signals synergize and potentiate vascular inflammation in a mast cell-dependent manner through cysteinyl leukotriene receptor 1 and E-prostanoid receptor 3.	Leukotriene D4	0-14	cysteinyl leukotriene receptor 1	Mus musculus	131-163
24211746-0	2014	The inflammatory mediator leukotriene D4 induces subcellular beta-catenin translocation and migration of colon cancer cells.	Leukotriene D4	26-40	catenin beta 1	Homo sapiens	61-73
26216432-1	2015	Leukotriene D4 (LTD4) is a pro-inflammatory mediator formed from arachidonic acid through the action of 5-lipoxygenase (5-LOX).	Leukotriene D4	0-14	arachidonate 5-lipoxygenase	Homo sapiens	104-118
26216432-1	2015	Leukotriene D4 (LTD4) is a pro-inflammatory mediator formed from arachidonic acid through the action of 5-lipoxygenase (5-LOX).	Leukotriene D4	16-20	arachidonate 5-lipoxygenase	Homo sapiens	104-118
25231108-0	2014	Protein kinase C-mediated phosphorylation of RKIP regulates inhibition of Na-alanine cotransport by leukotriene D(4) in intestinal epithelial cells.	Leukotriene D4	100-113	phosphatidylethanolamine binding protein 1	Homo sapiens	45-49
24211746-3	2014	The pro-inflammatory mediator leukotriene D4 (LTD4) exerts its effects through the CysLT1 receptor.	Leukotriene D4	30-44	cysteinyl leukotriene receptor 1	Homo sapiens	83-89
26318198-6	2015	fully attenuated CysLT1-mediated bronchoconstriction and airway vascular hyperpermeability induced by LTD4.	Leukotriene D4	102-106	cysteinyl leukotriene receptor 1	Homo sapiens	17-23
22078634-6	2012	Both xestospongin C, a specific inhibitor of inositol 1,4,5-triphosphate receptors (IP(3)R), and ryanodine or ruthenium red, inhibitors of RyR, partially blocked LTD4-induced Ca(2+) oscillations.	Leukotriene D4	162-166	ryanodine receptor 1	Homo sapiens	139-142
24141567-0	2014	Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro.	Leukotriene D4	42-46	cysteinyl leukotriene receptor 1	Mus musculus	0-32
23583294-5	2013	Identification of the receptors involved in these changes indicated that cysteinyl-leukotriene receptor 1 participates in the effects of leukotriene D4.	Leukotriene D4	137-151	cysteinyl leukotriene receptor 1	Homo sapiens	73-105
22982445-0	2013	Leukotriene D4 induces cognitive impairment through enhancement of CysLT1 R-mediated amyloid-beta generation in mice.	Leukotriene D4	0-14	cysteinyl leukotriene receptor 1	Mus musculus	67-75
22078634-2	2012	The aim of this study was to assess effects of IL-13 on Ca(2+) oscillations in response to leukotriene D4 (LTD4) in human cultured ASMCs.	Leukotriene D4	91-105	interleukin 13	Homo sapiens	47-52
22078634-2	2012	The aim of this study was to assess effects of IL-13 on Ca(2+) oscillations in response to leukotriene D4 (LTD4) in human cultured ASMCs.	Leukotriene D4	107-111	interleukin 13	Homo sapiens	47-52
23318673-0	2013	Leukotriene D4 induces amyloid-beta generation via CysLT(1)R-mediated NF-kappaB pathways in primary neurons.	Leukotriene D4	0-14	cysteinyl leukotriene receptor 1	Homo sapiens	51-60
23318673-0	2013	Leukotriene D4 induces amyloid-beta generation via CysLT(1)R-mediated NF-kappaB pathways in primary neurons.	Leukotriene D4	0-14	nuclear factor kappa B subunit 1	Homo sapiens	70-79
19679609-0	2010	Leukotriene D4 activates {beta}2-integrin adhesion in human polymorphonuclear leukocytes.	Leukotriene D4	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	26-32
21482134-0	2011	Leukotriene D4 enhances tumor necrosis factor-alpha-induced vascular endothelial growth factor production in human monocytes/macrophages.	Leukotriene D4	0-14	tumor necrosis factor	Homo sapiens	24-51
21482134-0	2011	Leukotriene D4 enhances tumor necrosis factor-alpha-induced vascular endothelial growth factor production in human monocytes/macrophages.	Leukotriene D4	0-14	vascular endothelial growth factor A	Homo sapiens	60-94
20889674-2	2010	We explored the hypothesis that leukotriene D4 (LTD4) may trigger the release of proremodeling factors through activation of the EGF receptor (EGFR).	Leukotriene D4	32-46	epidermal growth factor receptor	Homo sapiens	129-141
20889674-2	2010	We explored the hypothesis that leukotriene D4 (LTD4) may trigger the release of proremodeling factors through activation of the EGF receptor (EGFR).	Leukotriene D4	32-46	epidermal growth factor receptor	Homo sapiens	143-147
20889674-2	2010	We explored the hypothesis that leukotriene D4 (LTD4) may trigger the release of proremodeling factors through activation of the EGF receptor (EGFR).	Leukotriene D4	48-52	epidermal growth factor receptor	Homo sapiens	129-141
20889674-2	2010	We explored the hypothesis that leukotriene D4 (LTD4) may trigger the release of proremodeling factors through activation of the EGF receptor (EGFR).	Leukotriene D4	48-52	epidermal growth factor receptor	Homo sapiens	143-147
20889674-3	2010	We particularly focused on the effects of LTD4 on release of heparin-binding EGF-like factor (HB-EGF) and IL-8 (CXCL8), a potent neutrophil chemoattractant that may be released downstream of EGFR activation.	Leukotriene D4	42-46	heparin binding EGF like growth factor	Homo sapiens	61-92
20889674-3	2010	We particularly focused on the effects of LTD4 on release of heparin-binding EGF-like factor (HB-EGF) and IL-8 (CXCL8), a potent neutrophil chemoattractant that may be released downstream of EGFR activation.	Leukotriene D4	42-46	heparin binding EGF like growth factor	Homo sapiens	94-100
20889674-3	2010	We particularly focused on the effects of LTD4 on release of heparin-binding EGF-like factor (HB-EGF) and IL-8 (CXCL8), a potent neutrophil chemoattractant that may be released downstream of EGFR activation.	Leukotriene D4	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
20889674-3	2010	We particularly focused on the effects of LTD4 on release of heparin-binding EGF-like factor (HB-EGF) and IL-8 (CXCL8), a potent neutrophil chemoattractant that may be released downstream of EGFR activation.	Leukotriene D4	42-46	C-X-C motif chemokine ligand 8	Homo sapiens	112-117
21078884-4	2011	Both LTC4 and LTD4 are potent agonists for the CysLT2 receptor; however, LTC4 is rapidly converted to LTD4, which is also the main endogenous ligand for the CysLT1 receptor.	Leukotriene D4	14-18	cysteinyl leukotriene receptor 2	Mus musculus	47-53
21078884-4	2011	Both LTC4 and LTD4 are potent agonists for the CysLT2 receptor; however, LTC4 is rapidly converted to LTD4, which is also the main endogenous ligand for the CysLT1 receptor.	Leukotriene D4	14-18	cysteinyl leukotriene receptor 1	Mus musculus	157-163
21203429-2	2010	Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2).	Leukotriene D4	0-13	cysteinyl leukotriene receptor 1	Homo sapiens	94-102
21203429-2	2010	Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2).	Leukotriene D4	0-13	cysteinyl leukotriene receptor 2	Homo sapiens	107-115
19846883-9	2009	Taken together, our findings indicate that zymosan down-regulates CysLT1 expression in DCs with consequently reduced functional responsiveness of the cells to leukotriene D(4) stimulation.	Leukotriene D4	159-172	cysteinyl leukotriene receptor 1	Homo sapiens	66-72
17627891-0	2007	Leukotriene D(4) enhances the function of endothelin-1-primed fibroblasts.	Leukotriene D4	0-13	endothelin 1	Homo sapiens	42-54
19234368-0	2009	Leukotriene D4 stimulates the migration but not proliferation of endothelial cells mediated by the cysteinyl leukotriene cyslt(1) receptor via the extracellular signal-regulated kinase pathway.	Leukotriene D4	0-14	cysteinyl leukotriene receptor 1	Homo sapiens	121-128
19561298-0	2009	GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4.	Leukotriene D4	82-96	G protein-coupled receptor 17	Mus musculus	0-5
19454674-0	2009	The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.	Leukotriene D4	18-32	cysteinyl leukotriene receptor 1	Homo sapiens	4-10
19454674-0	2009	The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells.	Leukotriene D4	18-32	CD34 molecule	Homo sapiens	110-114
19124756-4	2009	Leukotriene (LT) D4, the most potent CysLT1R ligand, and UDP both induced phosphorylation of ERK and prolonged the survival of cytokine-starved hMCs and mBMMCs.	Leukotriene D4	0-19	cysteinyl leukotriene receptor 1	Homo sapiens	37-44
19124756-4	2009	Leukotriene (LT) D4, the most potent CysLT1R ligand, and UDP both induced phosphorylation of ERK and prolonged the survival of cytokine-starved hMCs and mBMMCs.	Leukotriene D4	0-19	mitogen-activated protein kinase 1	Homo sapiens	93-96
19124756-4	2009	Leukotriene (LT) D4, the most potent CysLT1R ligand, and UDP both induced phosphorylation of ERK and prolonged the survival of cytokine-starved hMCs and mBMMCs.	Leukotriene D4	0-19	Miles-Carpenter X-linked mental retardation syndrome	Homo sapiens	144-148
18323532-0	2008	Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling.	Leukotriene D4	0-14	furin, paired basic amino acid cleaving enzyme	Homo sapiens	28-33
18323532-0	2008	Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling.	Leukotriene D4	0-14	cysteinyl leukotriene receptor 1	Homo sapiens	53-59
18174606-6	2008	We show that the CysLT2R ligand, leukotriene D(4) (LTD4), is able to activate this chimeric receptor through activation of the Gi pathway.	Leukotriene D4	33-46	cysteinyl leukotriene receptor 2	Homo sapiens	17-24
18083053-0	2008	Leukotriene D(4) induces AP-1 but not NFkappaB signaling in intestinal epithelial cells.	Leukotriene D4	0-13	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	25-29
18176092-0	2008	Leukotriene D4 upregulates MUC2 gene transcription in human epithelial cells.	Leukotriene D4	0-14	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	27-31
17941281-5	2007	RESULTS: CysLT1R and CysLT2R mRNA was increased after stimulation with leukotriene D4.	Leukotriene D4	71-85	cysteinyl leukotriene receptor 1	Homo sapiens	9-16
17941281-5	2007	RESULTS: CysLT1R and CysLT2R mRNA was increased after stimulation with leukotriene D4.	Leukotriene D4	71-85	cysteinyl leukotriene receptor 2	Homo sapiens	21-28
17223000-0	2007	The inhibitory effect of the leukotriene receptor antagonist on leukotriene D4-induced MUC2/5AC gene expression and mucin secretion in human airway epithelial cells.	Leukotriene D4	64-78	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	87-91
17223000-8	2007	Pranlukast hydrate (ONO-1078, 100 microM) downregulated the leukotriene D(4)-induced MUC2/5AC gene expression and mucin secretion.	Leukotriene D4	60-76	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	85-89
17392478-6	2007	Similarly, for human monocytes, PKC inhibition augmented LTD4-stimulated calcium flux and cell migration assessed in transwell chamber experiments and also augmented LTD4-induced production of monocyte chemotactic protein assessed by ELISA.	Leukotriene D4	57-61	proline rich transmembrane protein 2	Homo sapiens	32-35
18516250-5	2007	Labeled leukotriene D(4) is prepared by treatment of labeled leukotriene C(4) with commercially available gamma-glutamyl transpeptidase.	Leukotriene D4	8-21	inactive glutathione hydrolase 2	Homo sapiens	106-135
17223000-8	2007	Pranlukast hydrate (ONO-1078, 100 microM) downregulated the leukotriene D(4)-induced MUC2/5AC gene expression and mucin secretion.	Leukotriene D4	60-76	LOC100508689	Homo sapiens	114-119
17223000-5	2007	METHODS: The effect of leukotriene D(4) and the leukotriene receptor antagonist, pranlukast hydrate (ONO-1078) on the regulation of MUC2/5AC gene expression and mucin secretion were observed in human airway NCI-H292 epithelial cells.	Leukotriene D4	23-36	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	132-136
17010308-0	2006	Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression.	Leukotriene D4	0-14	cysteinyl leukotriene receptor 2	Rattus norvegicus	48-54
17010308-0	2006	Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression.	Leukotriene D4	0-14	aquaporin 4	Rattus norvegicus	73-84
16715140-0	2006	Endogenous production of leukotriene D4 mediates autocrine survival and proliferation via CysLT1 receptor signalling in intestinal epithelial cells.	Leukotriene D4	25-39	cysteinyl leukotriene receptor 1	Homo sapiens	90-96
16630953-0	2006	Leukotriene D4 enhances immunoglobulin production in CD40-activated human B lymphocytes.	Leukotriene D4	0-14	CD40 molecule	Homo sapiens	53-57
16875498-4	2006	We tested the hypothesis that leukotriene D4 (LTD4) and allergen challenge cause beta2-adrenoceptor desensitization through the activation of protein kinase C (PKC).	Leukotriene D4	30-44	adrenoceptor beta 2	Homo sapiens	81-99
16553950-9	2006	Accordingly, we found that LTD4 stimulation was able to trigger the increase of Ras-GTP and, in turn, to activate ERK1/2.	Leukotriene D4	27-31	mitogen-activated protein kinase 3	Homo sapiens	114-120
16407243-5	2006	We also show that in the presence of LTD4, free beta-catenin translocates to the mitochondria where it associates with the cell survival protein Bcl-2.	Leukotriene D4	37-41	BCL2 apoptosis regulator	Homo sapiens	145-150
16407243-6	2006	We hypothesize that LTD4 may enhance cell survival via activation of beta-catenin signaling, in particular, by promoting the association of beta-catenin with Bcl-2 in the mitochondria.	Leukotriene D4	20-24	catenin beta 1	Homo sapiens	69-81
16407243-0	2006	The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells.	Leukotriene D4	26-40	catenin beta 1	Homo sapiens	49-61
16407243-6	2006	We hypothesize that LTD4 may enhance cell survival via activation of beta-catenin signaling, in particular, by promoting the association of beta-catenin with Bcl-2 in the mitochondria.	Leukotriene D4	20-24	catenin beta 1	Homo sapiens	140-152
16407243-6	2006	We hypothesize that LTD4 may enhance cell survival via activation of beta-catenin signaling, in particular, by promoting the association of beta-catenin with Bcl-2 in the mitochondria.	Leukotriene D4	20-24	BCL2 apoptosis regulator	Homo sapiens	158-163
16109507-0	2005	Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts.	Leukotriene D4	0-14	fibronectin 1	Homo sapiens	27-38
16407243-0	2006	The inflammatory mediator leukotriene D4 induces beta-catenin signaling and its association with antiapoptotic Bcl-2 in intestinal epithelial cells.	Leukotriene D4	26-40	BCL2 apoptosis regulator	Homo sapiens	111-116
16407243-5	2006	We also show that in the presence of LTD4, free beta-catenin translocates to the mitochondria where it associates with the cell survival protein Bcl-2.	Leukotriene D4	37-41	catenin beta 1	Homo sapiens	48-60
16772722-8	2006	RESULTS: Montelukast, but not salbutamol (both at 1 microM), inhibited LTD4-induced (100 nM) eosinophil adhesion to recombinant human intercellular adhesion molecule 1.	Leukotriene D4	71-75	intercellular adhesion molecule 1	Homo sapiens	134-167
16311922-6	2005	PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2.	Leukotriene D4	73-87	programmed cell death 2	Homo sapiens	0-5
16311922-6	2005	PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2.	Leukotriene D4	73-87	interleukin 2	Homo sapiens	130-134
15975962-0	2005	Activation of cPLA2 is required for leukotriene D4-induced proliferation in colon cancer cells.	Leukotriene D4	36-50	phospholipase A2 group IVA	Homo sapiens	14-19
15970283-0	2005	Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells.	Leukotriene D4	40-56	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	0-36
15970283-0	2005	Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells.	Leukotriene D4	40-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-84
15888248-7	2005	The increase in [Ca2+]i elicited by LTD4 (0.1 microM) and 2MeSATP (100 microM), agonists for CysLT- and P2Y1-receptors, was abolished by the respective antagonists, BAYu9773 (0.5 microM) and suramin (50 microM).	Leukotriene D4	36-40	purinergic receptor P2Y1	Rattus norvegicus	104-108
15657050-0	2005	The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells.	Leukotriene D4	30-44	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	53-82
15657050-0	2005	The pro-inflammatory mediator leukotriene D4 induces phosphatidylinositol 3-kinase and Rac-dependent migration of intestinal epithelial cells.	Leukotriene D4	30-44	AKT serine/threonine kinase 1	Homo sapiens	87-90
15990778-8	2005	Increases in cytosolic calcium induced by LTD 4 -stimulated basophils were inhibited by the cysLT1 receptor antagonist zafirlukast, confirming the presence of functional cysLT1 receptors on basophils.	Leukotriene D4	42-47	cysteinyl leukotriene receptor 1	Homo sapiens	92-98
15990778-8	2005	Increases in cytosolic calcium induced by LTD 4 -stimulated basophils were inhibited by the cysLT1 receptor antagonist zafirlukast, confirming the presence of functional cysLT1 receptors on basophils.	Leukotriene D4	42-47	cysteinyl leukotriene receptor 1	Homo sapiens	170-176
15388786-7	2005	The 5-lipoxygenase products leuko-triene B(4) and 5-oxo-6,8,11,14-eicosatetraenoic acid also stimulated CD203c expression but to a lesser extent than PGD(2), whereas leukotriene D(4) was inactive.	Leukotriene D4	166-179	arachidonate 5-lipoxygenase	Homo sapiens	4-18
15563687-7	2005	IL-13 induced calcium transients in cultured murine ASM cells and augmented the calcium and contractile responses of these cells to leukotriene D4.	Leukotriene D4	132-146	interleukin 13	Mus musculus	0-5
15388786-7	2005	The 5-lipoxygenase products leuko-triene B(4) and 5-oxo-6,8,11,14-eicosatetraenoic acid also stimulated CD203c expression but to a lesser extent than PGD(2), whereas leukotriene D(4) was inactive.	Leukotriene D4	166-179	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	104-110
15541723-0	2005	Leukotriene D4 activates distinct G-proteins in intestinal epithelial cells to regulate stress fibre formation and to generate intracellular Ca2+ mobilisation and ERK1/2 activation.	Leukotriene D4	0-14	mitogen-activated protein kinase 3	Homo sapiens	163-169
15292649-5	2004	Phorbol 12-myristate 13-acetate (PMA), lipoteichoic acid (LTA), lipopolysaccharide (LPS) and leukotriene D4 (LTD4) significantly increased MUC2 luciferase activities in the following order: PMA > LTA > LTD4 > LPS.	Leukotriene D4	93-107	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	139-143
15947480-0	2005	Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils.	Leukotriene D4	0-14	transforming growth factor beta 1	Homo sapiens	37-69
15609771-0	2004	Leukotriene D4 and eosinophil transendothelial migration, superoxide generation, and degranulation via beta2 integrin.	Leukotriene D4	0-14	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	103-108
15609771-3	2004	We previously reported that leukotriene D4 augments the expression of eosinophil beta2 integrin and the adhesion of eosinophils to rh intercellular adhesion molecule 1 via beta2 integrin.	Leukotriene D4	28-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	81-86
15609771-3	2004	We previously reported that leukotriene D4 augments the expression of eosinophil beta2 integrin and the adhesion of eosinophils to rh intercellular adhesion molecule 1 via beta2 integrin.	Leukotriene D4	28-42	intercellular adhesion molecule 1	Homo sapiens	134-167
15609771-3	2004	We previously reported that leukotriene D4 augments the expression of eosinophil beta2 integrin and the adhesion of eosinophils to rh intercellular adhesion molecule 1 via beta2 integrin.	Leukotriene D4	28-42	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	172-177
15609771-9	2004	CONCLUSIONS: Leukotriene D4 directly up-regulates the TEM and effector functions of eosinophils mainly via the cysLT1 receptor and beta2 integrin.	Leukotriene D4	13-27	cysteinyl leukotriene receptor 1	Homo sapiens	111-117
15609771-9	2004	CONCLUSIONS: Leukotriene D4 directly up-regulates the TEM and effector functions of eosinophils mainly via the cysLT1 receptor and beta2 integrin.	Leukotriene D4	13-27	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	131-136
14757222-1	2004	Addition of LTD4 (10 nM) to Xenopus laevis oocytes expressing the mCysLT1 receptor together with hBK or hIK channels resulted in the activation of both channels secondary to an LTD4-induced increase in [Ca2+]i.	Leukotriene D4	12-16	cysteinyl leukotriene receptor 1	Mus musculus	66-73
15316508-0	2004	Leukotriene D4 stimulates collagen production from myofibroblasts transformed by TGF-beta.	Leukotriene D4	0-14	transforming growth factor beta 1	Homo sapiens	81-89
15180633-0	2004	Identification of multidrug resistance-associated protein 1 and glutathione as multidrug resistance mechanisms in human prostate cancer cells: chemosensitization with leukotriene D4 antagonists and buthionine sulfoximine.	Leukotriene D4	167-181	ATP binding cassette subfamily C member 1	Homo sapiens	18-59
14757222-1	2004	Addition of LTD4 (10 nM) to Xenopus laevis oocytes expressing the mCysLT1 receptor together with hBK or hIK channels resulted in the activation of both channels secondary to an LTD4-induced increase in [Ca2+]i.	Leukotriene D4	12-16	hemoglobin subunit mu	Homo sapiens	97-100
14757222-1	2004	Addition of LTD4 (10 nM) to Xenopus laevis oocytes expressing the mCysLT1 receptor together with hBK or hIK channels resulted in the activation of both channels secondary to an LTD4-induced increase in [Ca2+]i.	Leukotriene D4	177-181	cysteinyl leukotriene receptor 1	Mus musculus	66-73
14757222-1	2004	Addition of LTD4 (10 nM) to Xenopus laevis oocytes expressing the mCysLT1 receptor together with hBK or hIK channels resulted in the activation of both channels secondary to an LTD4-induced increase in [Ca2+]i.	Leukotriene D4	177-181	hemoglobin subunit mu	Homo sapiens	97-100
12969770-6	2003	In non-sensitised animals, hyperresponsiveness to leukotriene D4 was developed by a bradykinin B2 receptor agonist, bradykinin, but not by a bradykinin B1 receptor agonist, des-Arg10-kallidin, while in the sensitised-challenged animal, both agonists developed hyperresponsiveness.	Leukotriene D4	50-64	B2 bradykinin receptor	Cavia porcellus	84-106
12154081-0	2002	Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta.	Leukotriene D4	0-13	ras homolog family member A	Homo sapiens	97-101
12897744-9	2003	Leukotriene D(4) stimulated isolated lung MNCs to produce RANTES but not any other cytokines and also activated NF-kappa B in these cells.	Leukotriene D4	0-13	chemokine (C-C motif) ligand 5	Mus musculus	58-64
12897744-9	2003	Leukotriene D(4) stimulated isolated lung MNCs to produce RANTES but not any other cytokines and also activated NF-kappa B in these cells.	Leukotriene D4	0-13	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	112-122
12750271-7	2003	Treating the cells with leukotriene D4, a known MRP1 substrate, or VX-710, an MRP1 modulator, restored flutamide and hydroxyflutamide accumulation.	Leukotriene D4	24-38	MDM4 regulator of p53	Homo sapiens	48-52
12223454-9	2002	We show that LXA4 inhibits LTD4-stimulated activation of the PDGFRbeta and that LXA4 modulates PDGF-BB-stimulated tyrosine phosphorylation of the PDGFRb and subsequent mitogenic events.	Leukotriene D4	27-31	platelet-derived growth factor receptor beta	Cricetulus griseus	61-70
12223454-9	2002	We show that LXA4 inhibits LTD4-stimulated activation of the PDGFRbeta and that LXA4 modulates PDGF-BB-stimulated tyrosine phosphorylation of the PDGFRb and subsequent mitogenic events.	Leukotriene D4	27-31	platelet-derived growth factor receptor beta	Cricetulus griseus	61-67
12738806-7	2003	These enzymes are closely related to MBD-1 (EC 3.4.13.19), which is known to cleave leukotriene D4 (LTD4) and cystinyl-bis-glycine.	Leukotriene D4	84-98	dipeptidase 1	Mus musculus	37-42
12738806-7	2003	These enzymes are closely related to MBD-1 (EC 3.4.13.19), which is known to cleave leukotriene D4 (LTD4) and cystinyl-bis-glycine.	Leukotriene D4	100-104	dipeptidase 1	Mus musculus	37-42
12738806-12	2003	MBD-2 cleaves leukotriene D4 (LTD4) but not cystinyl-bis-glycine, while MBD-3 cleaves cystinyl-bis-glycine but not LTD4.	Leukotriene D4	14-28	dipeptidase 2	Mus musculus	0-5
12482325-0	2003	The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage.	Leukotriene D4	29-43	caspase 8	Homo sapiens	71-80
12482325-0	2003	The anti-apoptotic effect of leukotriene D4 involves the prevention of caspase 8 activation and Bid cleavage.	Leukotriene D4	29-43	BH3 interacting domain death agonist	Homo sapiens	96-99
12629151-3	2003	The toxicity was enhanced by the 5-LOX product leukotriene (LT)D(4) and reduced by the selective cysteinyl LT receptor (CysLT(1)) antagonist MK-571.	Leukotriene D4	47-64	lysyl oxidase	Homo sapiens	35-38
12154081-0	2002	Leukotriene D(4) induces stress-fibre formation in intestinal epithelial cells via activation of RhoA and PKCdelta.	Leukotriene D4	0-13	protein kinase C delta	Homo sapiens	106-114
12071848-0	2002	Leukotriene D4 induces association of active RhoA with phospholipase C-gamma1 in intestinal epithelial cells.	Leukotriene D4	0-14	phospholipase C gamma 1	Homo sapiens	55-77
12163373-0	2002	Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo.	Leukotriene D4	100-116	gamma-glutamyltransferase 5	Mus musculus	0-28
12163373-3	2002	Here we show that in vivo GGL, and not GGT as previously believed, is primarily responsible for conversion of leukotriene C(4) to leukotriene D(4), the most potent of the cysteinyl leukotrienes and the immediate precursor of leukotriene E(4).	Leukotriene D4	130-143	gamma-glutamyltransferase 5	Mus musculus	26-29
11956320-0	2002	Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells.	Leukotriene D4	0-13	mitogen-activated protein kinase 3	Homo sapiens	27-31
12063527-6	2002	LTC4 did not act directly but only after conversion to LTD4 because an inhibitor of gamma-glutamyl transpeptidase, acivicin, blocked LTC4-induced IL-4 release.	Leukotriene D4	55-59	inactive glutathione hydrolase 2	Homo sapiens	84-113
12063527-6	2002	LTC4 did not act directly but only after conversion to LTD4 because an inhibitor of gamma-glutamyl transpeptidase, acivicin, blocked LTC4-induced IL-4 release.	Leukotriene D4	55-59	interleukin 4	Homo sapiens	146-150
11956320-0	2002	Leukotriene D(4) activates MAPK through a Ras-independent but PKCepsilon-dependent pathway in intestinal epithelial cells.	Leukotriene D4	0-13	protein kinase C epsilon	Homo sapiens	62-72
11918713-6	2002	Leukotriene D4 release also increased at both 20 min and 16 h. Tumor necrosis factor-alpha increased significantly in foreskin mast cell culture challenged with sera of chronic urticaria patients.	Leukotriene D4	0-14	tumor necrosis factor	Homo sapiens	63-90
11815738-0	2001	The effect of leukotriene D(4) inhalation on the antigen-induced airway hyperresponsiveness and inflammation in 5-lipoxygenase gene-deficient mice.	Leukotriene D4	14-30	arachidonate 5-lipoxygenase	Mus musculus	112-126
11083457-2	2000	In platelets GGT converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4) and is involved in glutathione metabolism.	Leukotriene D4	51-65	gamma-glutamyltransferase 1	Homo sapiens	13-16
11369634-0	2001	Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1.	Leukotriene D4	121-135	cysteinyl leukotriene receptor 1	Homo sapiens	181-187
11369634-4	2001	Cysteinyl leukotrienes, particularly leukotriene D4 (LTD4), induced strong intracellular calcium fluxes and actin polymerization in mobilized and BM CD34(+) progenitors.	Leukotriene D4	37-51	CD34 molecule	Homo sapiens	149-153
11369634-4	2001	Cysteinyl leukotrienes, particularly leukotriene D4 (LTD4), induced strong intracellular calcium fluxes and actin polymerization in mobilized and BM CD34(+) progenitors.	Leukotriene D4	53-57	CD34 molecule	Homo sapiens	149-153
11350860-10	2001	We conclude that LTD4 causes constriction of these small bronchioles primarily by activating Ca2+ entry via non-voltage gated channels, possibly by a PC-PLC mediated pathway.	Leukotriene D4	17-21	heparan sulfate proteoglycan 2	Homo sapiens	153-156
11329379-0	2001	Leukotriene D(4) affects localisation of vinculin in intestinal epithelial cells via distinct tyrosine kinase and protein kinase C controlled events.	Leukotriene D4	0-13	vinculin	Homo sapiens	41-49
19667529-6	2000	The 2 LTRAs available for clinical use in the United States--montelukast and zafirlukast--are potent inhibitors of leukotriene D4 binding to the CysLT1 receptor.	Leukotriene D4	115-129	cysteinyl leukotriene receptor 1	Homo sapiens	145-151
11369634-0	2001	Chemotaxis and transendothelial migration of CD34(+) hematopoietic progenitor cells induced by the inflammatory mediator leukotriene D4 are mediated by the 7-transmembrane receptor CysLT1.	Leukotriene D4	121-135	CD34 molecule	Homo sapiens	45-49
11139333-1	2001	We investigated the potential roles of specific isoforms of protein kinase C (PKC) in the regulation of leukotriene D(4)-induced Ca(2+) signaling in the intestinal epithelial cell line Int 407.	Leukotriene D4	104-120	protein kinase C alpha	Homo sapiens	78-81
10913337-5	2000	In human embryonic kidney 293 cells that express the PSEC0146 cDNA, leukotriene C(4) (LTC(4)) and leukotriene D(4) (LTD(4)) induce equal increases in intracellular calcium mobilization; these increases are not affected by CysLT(1) antagonists.	Leukotriene D4	98-111	cysteinyl leukotriene receptor 2	Homo sapiens	53-61
10913337-5	2000	In human embryonic kidney 293 cells that express the PSEC0146 cDNA, leukotriene C(4) (LTC(4)) and leukotriene D(4) (LTD(4)) induce equal increases in intracellular calcium mobilization; these increases are not affected by CysLT(1) antagonists.	Leukotriene D4	98-111	cysteinyl leukotriene receptor 1	Homo sapiens	222-230
10394108-0	1999	Leukotriene D4 inhibits Na+ uptake through cAMP and PLC pathways in primary cultured renal proximal tubular cells.	Leukotriene D4	0-14	LOC100009319	Oryctolagus cuniculus	52-55
10208831-4	1999	The ability of exogenously applied leukotriene D4 (3x10(-9)M) to potentiate the endothelin-1-induced contractions was also investigated.	Leukotriene D4	35-49	endothelin 1	Homo sapiens	80-92
10208831-8	1999	The presence of leukotriene D4(3x10(-9)M), mimicked angiotensin II in significantly potentiating the endothelin-1-evoked responses.	Leukotriene D4	16-30	endothelin 1	Homo sapiens	101-113
9793684-0	1998	Leukotriene D4 induces a rapid increase in cAMP in the human epithelial cell line, Int 407: a potential role for this signal in the regulation of calcium influx through the plasma membrane.	Leukotriene D4	0-14	cathelicidin antimicrobial peptide	Homo sapiens	43-47
9774450-1	1998	We have recently identified a mouse enzyme termed gamma-glutamyl leukotrienase (GGL) that converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).	Leukotriene D4	124-138	gamma-glutamyltransferase 5	Mus musculus	50-78
9774450-1	1998	We have recently identified a mouse enzyme termed gamma-glutamyl leukotrienase (GGL) that converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4).	Leukotriene D4	124-138	gamma-glutamyltransferase 5	Mus musculus	80-83
9753495-1	1998	BACKGROUND & AIMS: In esophageal circular muscle, acetylcholine activates phosphatidylcholine-specific phospholipases C and D and phospholipase A2, producing diacylglycerol and arachidonic acid, which cause contraction by interacting synergistically to activate protein kinase C. In a model of acute esophagitis, leukotriene D4 (LTD4) contributes to acetylcholine-induced contraction.	Leukotriene D4	317-331	phospholipase A2 group IB	Homo sapiens	134-150
9690572-1	1998	BACKGROUND: Previous studies demonstrated that leukotriene receptor antagonists (LTRAs) are effective in reducing asthma symptoms and the airway response to inhaled leukotriene D4 (LTD4) in asthmatic patients receiving inhaled beta2-agonists alone.	Leukotriene D4	165-179	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	227-232
9793684-5	1998	Stimulation with LTD4, but not with the calcium ionophore ionomycin, triggered a rapid increase (peak at 7 s) in the cellular cAMP level, an effect that was totally abolished by pertussis toxin.	Leukotriene D4	17-21	cathelicidin antimicrobial peptide	Homo sapiens	126-130
9478929-0	1998	Leukotriene D4 activates mitogen-activated protein kinase through a protein kinase Calpha-Raf-1-dependent pathway in human monocytic leukemia THP-1 cells.	Leukotriene D4	0-14	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	90-95
9618707-1	1998	Peptide-leukotrienes (p-LTs) (LTC4, LTD4 and LTE4) are major metabolites of the arachidonate 5-lipoxygenase pathway.	Leukotriene D4	36-40	arachidonate 5-lipoxygenase	Homo sapiens	80-107
9478929-6	1998	Cytosolic protein kinase Calpha was translocated to the membrane, and Raf-1 was activated by LTD4 treatment in a similar time course.	Leukotriene D4	93-97	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	70-75
9374738-2	1997	gamma-Glutamyl transpeptidase-related enzyme (GGT-rel) is a novel protein capable of cleaving the gamma-glutamyl peptide bond of glutathione and of converting leukotriene C4 to leukotriene D4.	Leukotriene D4	177-191	gamma-glutamyltransferase 5	Rattus norvegicus	0-53
9374740-7	1997	Compared with SP release under control conditions (2.37 +/- 0.34%), major basic protein (MBP) increased release in a concentration-related fashion (e.g., 3 microM MBP: 6.23 +/- 0.67%, P = 0.006 vs. control), whereas neither eosinophil cationic protein (3 microM), eosinophil-derived neurotoxin (3 microM), leukotriene D4 (500 nM), platelet-activating factor (100 nM), nor H2O2 (100 microM) affected SP release.	Leukotriene D4	306-320	myelin basic protein	Homo sapiens	89-92
9635162-3	1998	Orally administered CDP-840 (10 mg/kg; 1 h before challenge) produced partial inhibition (41 and 45%, respectively) of both the acute (1 h post antigen) response and the late (3-5 h post antigen) response to antigen but failed to alter the response to an aerosol of leukotriene D4.	Leukotriene D4	266-280	cut like homeobox 1	Homo sapiens	20-23
9066788-8	1997	Following reexposure to IL-3, a rapid time-dependent biosynthesis of leukotriene D4 (LTD4) is induced by M-07e cells.	Leukotriene D4	69-83	interleukin 3	Homo sapiens	24-28
9365122-9	1997	Eotaxin and eotaxin-2 promote a Ca2+ transient in RBL-2H3 cells stably transfected with CCR3 (RBL-2H3-CCR3) and both ligands cross-desensitized the response of the other but not the response to LTD4.	Leukotriene D4	194-198	C-C motif chemokine ligand 11	Rattus norvegicus	0-7
9365122-9	1997	Eotaxin and eotaxin-2 promote a Ca2+ transient in RBL-2H3 cells stably transfected with CCR3 (RBL-2H3-CCR3) and both ligands cross-desensitized the response of the other but not the response to LTD4.	Leukotriene D4	194-198	C-C motif chemokine ligand 24	Rattus norvegicus	12-21
9176223-8	1997	We conclude that interleukin-4 amplifies cholinergic excitation through a mast cell and leukotriene D4-dependent mechanism.	Leukotriene D4	88-102	interleukin 4	Mus musculus	17-30
9152370-5	1997	Incubation of cultured human umbilical vein endothelial cells (HUVEC) with the cysteinyl leukotrienes leukotriene C4 (LTC4) or leukotriene D4 (LTD4) induced surface expression of P-selectin which was concentration dependent and rapid in onset.	Leukotriene D4	127-141	selectin P	Homo sapiens	179-189
9118902-5	1996	We have previously shown that benzene treatment of HL-60 myeloblasts activates protein kinase C (PKC) and upregulates the 5-lipoxygenase (LPO) pathway for the production of leukotriene D4 (LTD4), an essential effector or granulocytic differentiation.	Leukotriene D4	173-187	arachidonate 5-lipoxygenase	Mus musculus	122-136
9127275-1	1997	A steoreoselective high-performance liquid chromatographic method was developed for the quantification of montelukast (free acid of Singulair, or MK-0476), a potent and selective leukotriene D4 (cysLT1) receptor antagonist, and it S-enantiomers (L-768,232).	Leukotriene D4	179-193	cysteinyl leukotriene receptor 1	Homo sapiens	195-201
8997273-0	1996	Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells.	Leukotriene D4	0-14	matrix metallopeptidase 1	Homo sapiens	23-28
8997273-0	1996	Leukotriene D4 induces MMP-1, which functions as an IGFBP protease in human airway smooth muscle cells.	Leukotriene D4	0-14	insulin like growth factor binding protein 2	Homo sapiens	52-57
8997273-5	1996	Incubation with 125I-labeled IGFBP demonstrated that an IGFBP protease was induced in the ASM cells in response to LTD4 treatment.	Leukotriene D4	115-119	insulin like growth factor binding protein 2	Homo sapiens	29-34
8997273-5	1996	Incubation with 125I-labeled IGFBP demonstrated that an IGFBP protease was induced in the ASM cells in response to LTD4 treatment.	Leukotriene D4	115-119	insulin like growth factor binding protein 2	Homo sapiens	56-61
9118902-5	1996	We have previously shown that benzene treatment of HL-60 myeloblasts activates protein kinase C (PKC) and upregulates the 5-lipoxygenase (LPO) pathway for the production of leukotriene D4 (LTD4), an essential effector or granulocytic differentiation.	Leukotriene D4	173-187	arachidonate 5-lipoxygenase	Mus musculus	138-141
7616450-5	1995	Leukotriene D4 played a role in neurokinin A-mediated excitation as the leukotriene D4 receptor antagonist, WY 48,252, reduced the response to nerve stimulation under noncholinergic conditions by almost 80%.	Leukotriene D4	0-14	tachykinin 2	Mus musculus	32-44
8960868-6	1996	Studies with specific leukotriene D4 antagonists of the cysLT1 type receptor indicate that this leukotriene receptor is probably not involved directly in the eosinophilic inflammation.	Leukotriene D4	22-36	cysteinyl leukotriene receptor 1	Rattus norvegicus	56-62
8645211-6	1996	In accordance with this, we also found that both the LTD4-induced formation of inositol 1,4,5-trisphosphate and the LTD4-induced phosphorylation of phospholipase C gamma 1 (PLC gamma 1) on tyrosine residues were significantly reduced in compactin-pretreated cells.	Leukotriene D4	116-120	phospholipase C gamma 1	Homo sapiens	148-171
8645211-6	1996	In accordance with this, we also found that both the LTD4-induced formation of inositol 1,4,5-trisphosphate and the LTD4-induced phosphorylation of phospholipase C gamma 1 (PLC gamma 1) on tyrosine residues were significantly reduced in compactin-pretreated cells.	Leukotriene D4	116-120	phospholipase C gamma 1	Homo sapiens	173-184
7616450-9	1995	Instead leukotriene D4 may modulate the release of neurokinin A from nerve endings during nerve stimulation.	Leukotriene D4	8-22	tachykinin 2	Mus musculus	51-63
8933618-4	1996	BZ induces granulocytic differentiation by upregulating the production of leukotriene D4 (LTD4), an essential intracellular mediator of G-CSF signaling.	Leukotriene D4	74-88	colony stimulating factor 3 (granulocyte)	Mus musculus	136-141
7559525-10	1995	Functionally, up-regulation of PDE4 markedly decreased the ability of PGE2 to inhibit LTD4-induced Ca2+ mobilization in intact cells.	Leukotriene D4	86-90	phosphodiesterase 4A	Homo sapiens	31-35
8313527-0	1994	H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883.	Leukotriene D4	118-132	Harvey rat sarcoma virus oncogene	Mus musculus	0-5
7624871-9	1995	AT-125 (Acivicin) inhibits gamma-glutamyl transferase (GGT), the enzyme that catalyzes the formation of LTD4 from LTC4.	Leukotriene D4	104-108	gamma-glutamyltransferase 1	Rattus norvegicus	27-53
7624871-9	1995	AT-125 (Acivicin) inhibits gamma-glutamyl transferase (GGT), the enzyme that catalyzes the formation of LTD4 from LTC4.	Leukotriene D4	104-108	gamma-glutamyltransferase 1	Rattus norvegicus	55-58
7661877-3	1995	In this study the effects of cysteinyl-leukotriene D4 (LTD4) on IL-1 beta production and IL-1 beta mRNA expression were tested on rat VSMC.	Leukotriene D4	55-59	interleukin 1 beta	Rattus norvegicus	64-73
7542115-5	1995	Treatment of HL-60 myeloblasts with BZ activated protein kinase C and upregulated the 5-lipoxygenase (LPO) pathway for the production of leukotriene D4 (LTD4), an essential effector of granulocytic differentiation.	Leukotriene D4	137-151	arachidonate 5-lipoxygenase	Homo sapiens	86-100
7542115-5	1995	Treatment of HL-60 myeloblasts with BZ activated protein kinase C and upregulated the 5-lipoxygenase (LPO) pathway for the production of leukotriene D4 (LTD4), an essential effector of granulocytic differentiation.	Leukotriene D4	137-151	arachidonate 5-lipoxygenase	Homo sapiens	102-105
7734448-8	1995	Erythrocytes demonstrated endogenous synthesis of LTD4 which was inhibited by non-selective (NDGA) and specific (MK886) 5-lipoxygenase inhibitors.	Leukotriene D4	50-54	arachidonate 5-lipoxygenase	Homo sapiens	120-134
8171072-2	1994	Normal brain capillaries are rich in gamma-glutamyl transpeptidase (gamma-GTP), an enzyme which converts LTC4 to leukotriene D4 (LTD4), and acts as an "enzymatic barrier" to the vasoactive effects of LTC4.	Leukotriene D4	113-127	gamma-glutamyltransferase 1	Rattus norvegicus	37-66
8171072-2	1994	Normal brain capillaries are rich in gamma-glutamyl transpeptidase (gamma-GTP), an enzyme which converts LTC4 to leukotriene D4 (LTD4), and acts as an "enzymatic barrier" to the vasoactive effects of LTC4.	Leukotriene D4	113-127	gamma-glutamyltransferase 1	Rattus norvegicus	68-77
8171072-2	1994	Normal brain capillaries are rich in gamma-glutamyl transpeptidase (gamma-GTP), an enzyme which converts LTC4 to leukotriene D4 (LTD4), and acts as an "enzymatic barrier" to the vasoactive effects of LTC4.	Leukotriene D4	129-133	gamma-glutamyltransferase 1	Rattus norvegicus	37-66
8171072-2	1994	Normal brain capillaries are rich in gamma-glutamyl transpeptidase (gamma-GTP), an enzyme which converts LTC4 to leukotriene D4 (LTD4), and acts as an "enzymatic barrier" to the vasoactive effects of LTC4.	Leukotriene D4	129-133	gamma-glutamyltransferase 1	Rattus norvegicus	68-77
1725762-5	1991	VIP (10 nM) induced a potent and reversible inhibition of the contractions of GPP induced by LTD4 (1-30 pmol) but did not affect those due to ACh (1-100 nmol) or histamine (1-30 nmol).	Leukotriene D4	93-97	VIP peptides	Cavia porcellus	0-3
8368641-0	1993	Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis.	Leukotriene D4	10-24	PCNA clamp associated factor	Homo sapiens	100-103
8124204-6	1993	Subsequent to kinase C activation, arachidonic acid was released from membrane phospholipids and the 5-lipoxygenase pathway was activated for the production of leukotriene D4 (LTD4) required for granulocytic differentiation.	Leukotriene D4	160-174	arachidonate 5-lipoxygenase	Homo sapiens	101-115
8124204-6	1993	Subsequent to kinase C activation, arachidonic acid was released from membrane phospholipids and the 5-lipoxygenase pathway was activated for the production of leukotriene D4 (LTD4) required for granulocytic differentiation.	Leukotriene D4	176-180	arachidonate 5-lipoxygenase	Homo sapiens	101-115
8093353-1	1993	The enzyme gamma-glutamyl transferase (GGT) is a multifunctional enzyme that participates in a number of metabolic processes, including the conversion of leukotriene C4(LTC4) to leukotriene D4(LTD4).	Leukotriene D4	178-192	gamma-glutamyltransferase 1	Homo sapiens	11-37
8093353-1	1993	The enzyme gamma-glutamyl transferase (GGT) is a multifunctional enzyme that participates in a number of metabolic processes, including the conversion of leukotriene C4(LTC4) to leukotriene D4(LTD4).	Leukotriene D4	178-192	gamma-glutamyltransferase 1	Homo sapiens	39-42
1747111-2	1991	The purpose of this investigation was to determine whether LY171883, a leukotriene D4 antagonist, and other peroxisome proliferators bind to FABP and displace an endogenous fatty acid.	Leukotriene D4	71-85	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	141-145
2043662-3	1991	Ca2+ mobilization following stimulation with LTD4 (10 nM) or ATP (10 microM) was not affected.	Leukotriene D4	45-49	carbonic anhydrase 2	Homo sapiens	0-3
2052621-3	1991	The steady-state levels of PLAP mRNA are induced in smooth muscle and endothelial cells following treatment with leukotriene D4.	Leukotriene D4	113-127	phospholipase A2 activating protein	Homo sapiens	27-31
2052621-5	1991	Synthetic antisense DNA was used to block the synthesis of PLAP and this treatment effectively blocked the activation of phospholipase A2 and the increased generation of prostanoids in smooth muscle and endothelial cells treated with leukotriene D4.	Leukotriene D4	234-248	phospholipase A2 activating protein	Homo sapiens	59-63
2052621-5	1991	Synthetic antisense DNA was used to block the synthesis of PLAP and this treatment effectively blocked the activation of phospholipase A2 and the increased generation of prostanoids in smooth muscle and endothelial cells treated with leukotriene D4.	Leukotriene D4	234-248	phospholipase A2 group IB	Homo sapiens	121-137
1650832-1	1991	Pharmacological analysis of the effects of leukotriene D4 (LTD4) antagonists on contraction of guinea pig airway smooth muscle to leukotrienes reveals the presence of two subtypes of the LTD4 receptor.	Leukotriene D4	43-57	cysteinyl leukotriene receptor 1	Cavia porcellus	187-200
1650832-1	1991	Pharmacological analysis of the effects of leukotriene D4 (LTD4) antagonists on contraction of guinea pig airway smooth muscle to leukotrienes reveals the presence of two subtypes of the LTD4 receptor.	Leukotriene D4	59-63	cysteinyl leukotriene receptor 1	Cavia porcellus	187-200
2122641-0	1990	The role of phospholipase A2 activating protein (PLAP) in regulating prostanoid production in smooth muscle and endothelial cells following leukotriene D4 treatment.	Leukotriene D4	140-154	phospholipase A2 activating protein	Homo sapiens	12-47
1714396-2	1991	The relaxant effect of VIP was greater when the magnitude of the leukotriene D4 (LTD4)-induced contraction was smaller.	Leukotriene D4	65-79	VIP peptides	Cavia porcellus	23-26
1714396-2	1991	The relaxant effect of VIP was greater when the magnitude of the leukotriene D4 (LTD4)-induced contraction was smaller.	Leukotriene D4	81-85	VIP peptides	Cavia porcellus	23-26
1952571-0	1991	Leukotriene (LT) D4 is involved in antigen-induced asthma: a study with the LTD4 receptor antagonist, MK-571.	Leukotriene D4	0-19	cysteinyl leukotriene receptor 1	Homo sapiens	76-89
2117981-4	1990	In guinea-pig lung, ibudilast inhibited LTD4 (0.01-1 microM)-induced formation of inositol monophosphate (IP1) in a concentration-dependent manner (IC50 = 10 microM) without affecting LTD4 receptor binding.	Leukotriene D4	40-44	cysteinyl leukotriene receptor 1	Cavia porcellus	184-197
2122641-0	1990	The role of phospholipase A2 activating protein (PLAP) in regulating prostanoid production in smooth muscle and endothelial cells following leukotriene D4 treatment.	Leukotriene D4	140-154	phospholipase A2 activating protein	Homo sapiens	49-53
34299067-9	2021	Conversely, leukotriene D4 (LTD4), an agonist of CYSLTR1, increased cellular proliferation of pancreatic cancer cells with an accumulation of phospho-ERK1/2.	Leukotriene D4	12-26	cysteinyl leukotriene receptor 1	Homo sapiens	49-56
34299067-9	2021	Conversely, leukotriene D4 (LTD4), an agonist of CYSLTR1, increased cellular proliferation of pancreatic cancer cells with an accumulation of phospho-ERK1/2.	Leukotriene D4	28-32	cysteinyl leukotriene receptor 1	Homo sapiens	49-56