PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	Benzene oxide	76-78	glutathione S-transferase alpha 1	Homo sapiens	24-29
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	Benzene oxide	76-78	glutathione S-transferase theta 1	Homo sapiens	31-36
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	Benzene oxide	76-78	glutathione S-transferase mu 1	Homo sapiens	38-43
26554337-4	2015	Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione.	Benzene oxide	76-78	glutathione S-transferase pi 1	Homo sapiens	49-54
26554337-8	2015	We conclude that GSTT1 is a critical enzyme in the detoxification of BO and that GSTP1 may also play an important role, while GSTA1 and GSTM1 seem to be less important.	Benzene oxide	69-71	glutathione S-transferase theta 1	Homo sapiens	17-22
20036650-2	2010	Benzene is initially metabolized via cytochromes P450 (primarily CYP2E1 in liver) to benzene-oxide, which subsequently gives rise to a number of secondary products.	Benzene oxide	85-98	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	65-71
22153878-6	2012	Furthermore the genetic polymorphism of glutathione-S-transferase (GST) may be related to health effects of benzene exposure, in fact both genotype T1 (GSTT1) and M1 (GSTM1) are involved in the detoxification of benzene oxide.	Benzene oxide	212-225	glutathione S-transferase kappa 1	Homo sapiens	40-65
22153878-6	2012	Furthermore the genetic polymorphism of glutathione-S-transferase (GST) may be related to health effects of benzene exposure, in fact both genotype T1 (GSTT1) and M1 (GSTM1) are involved in the detoxification of benzene oxide.	Benzene oxide	212-225	glutathione S-transferase kappa 1	Homo sapiens	67-70
22153878-6	2012	Furthermore the genetic polymorphism of glutathione-S-transferase (GST) may be related to health effects of benzene exposure, in fact both genotype T1 (GSTT1) and M1 (GSTM1) are involved in the detoxification of benzene oxide.	Benzene oxide	212-225	glutathione S-transferase theta 1	Homo sapiens	152-157
22153878-6	2012	Furthermore the genetic polymorphism of glutathione-S-transferase (GST) may be related to health effects of benzene exposure, in fact both genotype T1 (GSTT1) and M1 (GSTM1) are involved in the detoxification of benzene oxide.	Benzene oxide	212-225	glutathione S-transferase mu 1	Homo sapiens	167-172
15935805-1	2005	We used cysteinyl adducts of serum albumin (Alb) to investigate the production of two reactive benzene metabolites, namely, benzene oxide (BO) and 1,4-benzoquinone (1,4-BQ) in workers exposed to benzene.	Benzene oxide	124-137	albumin	Homo sapiens	44-47
15935805-1	2005	We used cysteinyl adducts of serum albumin (Alb) to investigate the production of two reactive benzene metabolites, namely, benzene oxide (BO) and 1,4-benzoquinone (1,4-BQ) in workers exposed to benzene.	Benzene oxide	139-141	albumin	Homo sapiens	44-47
15935812-4	2005	NQO1 catalyzes the detoxication of benzene quinone metabolites and mEH catalyzes the hydrolysis of benzene oxide.	Benzene oxide	99-112	NAD(P)H dehydrogenase, quinone 1	Mus musculus	0-4
15935812-4	2005	NQO1 catalyzes the detoxication of benzene quinone metabolites and mEH catalyzes the hydrolysis of benzene oxide.	Benzene oxide	99-112	epoxide hydrolase 1, microsomal	Mus musculus	67-70
10746935-6	2000	Although adducts from reactions of BO and 1,4-BQ with Alb both decayed with rates consistent with those of Alb turnover in the rat, the half-life for 1,4-BQ-Alb (2.5 days) was shorter than that for BO-Alb (3.1 days), suggesting some instability of 1,4-BQ-Alb.	Benzene oxide	35-37	albumin	Rattus norvegicus	54-57
11888901-1	2002	Albumin adducts of benzene oxide (BO-Alb) and 1,4-benzoquinone (1,4-BQ-Alb) were investigated among 134 workers exposed to benzene and 51 unexposed controls in Tianjin, China.	Benzene oxide	19-32	albumin	Homo sapiens	0-3
11888901-1	2002	Albumin adducts of benzene oxide (BO-Alb) and 1,4-benzoquinone (1,4-BQ-Alb) were investigated among 134 workers exposed to benzene and 51 unexposed controls in Tianjin, China.	Benzene oxide	19-32	albumin	Homo sapiens	37-40
11489749-1	2001	Hemoglobin (Hb) and albumin (Alb) adducts of the benzene metabolites benzene oxide (BO) and 1,4-benzoquinone (1,4-BQ) were analyzed by gas chromatography-mass spectrometry in 43 exposed workers and 44 unexposed controls from Shanghai, China, as part of a larger cross-sectional study of benzene biomarkers.	Benzene oxide	69-82	albumin	Homo sapiens	29-32
11489749-1	2001	Hemoglobin (Hb) and albumin (Alb) adducts of the benzene metabolites benzene oxide (BO) and 1,4-benzoquinone (1,4-BQ) were analyzed by gas chromatography-mass spectrometry in 43 exposed workers and 44 unexposed controls from Shanghai, China, as part of a larger cross-sectional study of benzene biomarkers.	Benzene oxide	84-86	albumin	Homo sapiens	29-32
11489749-4	2001	When compared on an individual basis, Alb adducts of 1,4-BQ and BO and Hb adducts of BO were highly correlated with each other and with urinary phenol and hydroquinone (P < 0.0001 for all of the comparisons).	Benzene oxide	64-66	albumin	Homo sapiens	38-41
11489749-4	2001	When compared on an individual basis, Alb adducts of 1,4-BQ and BO and Hb adducts of BO were highly correlated with each other and with urinary phenol and hydroquinone (P < 0.0001 for all of the comparisons).	Benzene oxide	85-87	albumin	Homo sapiens	38-41
9548800-0	1998	Formation of hemoglobin and albumin adducts of benzene oxide in mouse, rat, and human blood.	Benzene oxide	47-60	albumin	Mus musculus	28-35
9771926-0	1998	Hemoglobin and albumin adducts of benzene oxide among workers exposed to high levels of benzene.	Benzene oxide	34-47	albumin	Homo sapiens	15-22
9771926-1	1998	Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb), which are presumed to be specific biomarkers of exposure to benzene.	Benzene oxide	0-13	albumin	Homo sapiens	73-80
9771926-1	1998	Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb), which are presumed to be specific biomarkers of exposure to benzene.	Benzene oxide	0-13	albumin	Homo sapiens	82-85
9771926-1	1998	Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb), which are presumed to be specific biomarkers of exposure to benzene.	Benzene oxide	0-13	albumin	Homo sapiens	125-128
9771926-1	1998	Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb), which are presumed to be specific biomarkers of exposure to benzene.	Benzene oxide	15-17	albumin	Homo sapiens	73-80
9771926-1	1998	Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb), which are presumed to be specific biomarkers of exposure to benzene.	Benzene oxide	15-17	albumin	Homo sapiens	82-85
9771926-1	1998	Benzene oxide (BO) reacts with cysteinyl residues in hemoglobin (Hb) and albumin (Alb) to form protein adducts (BO-Hb and BO-Alb), which are presumed to be specific biomarkers of exposure to benzene.	Benzene oxide	15-17	albumin	Homo sapiens	125-128
9771926-9	1998	These results clearly affirm the use of both Hb and Alb adducts of BO as biomarkers of exposure to high levels of benzene.	Benzene oxide	67-69	albumin	Homo sapiens	52-55
9548800-2	1998	In this study, reactions of BO with hemoglobin (Hb) and albumin (Alb) were investigated in blood from B6C3F1 mice, F344 rats, and humans in vitro.	Benzene oxide	28-30	albumin	Mus musculus	65-68
9548800-8	1998	Doses of BO predicted from Alb adducts were similar in workers exposed to benzene [13.3 nM BO-h (mg of benzene/kg of body weight)-1] and in rats following a single gavage dose of benzene [8.	Benzene oxide	9-11	albumin	Rattus norvegicus	27-30
9010585-10	1996	Therefore, CYP2B1 and 2E1 in rats appeared essential for metabolic activation of benzene derivatives to potentially genotoxic products; BQ dominated the covalent binding of benzene to proteins, whereas DNA adducts were largely due to benzene oxide.	Benzene oxide	234-247	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	11-25
8908188-6	1996	Stable analogs of the valence tautomer benzene oxide, namely syn-indan-3a,7a-oxide and syn-2-hydroxyindan-3a,7a-oxide, were mutagenic and induced point mutations.	Benzene oxide	39-52	synapsin II	Homo sapiens	87-92