PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26646778-8	2016	Our results also indicated that expressions of interleukin (IL)-1alpha, IL-1beta, IL-6, granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in gut tissue were downregulated by treatments of TFDG, and immunity cytokine secretions in the serum were regulated after oral administration of TFDG.	tfdg	229-233	interleukin 1 alpha	Homo sapiens	47-70
26646778-8	2016	Our results also indicated that expressions of interleukin (IL)-1alpha, IL-1beta, IL-6, granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in gut tissue were downregulated by treatments of TFDG, and immunity cytokine secretions in the serum were regulated after oral administration of TFDG.	tfdg	325-329	interleukin 1 alpha	Homo sapiens	47-70
35621148-2	2022	This study aimed to assess the effects of total flavonoid extracts (TFDG) and the monomers of Daphne genkwa on the CYP2C8 activity in vitro and in vivo.2.	tfdg	68-72	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	115-121
34208050-5	2021	EGCG, TSA, and TFDG significantly inhibited interaction between recombinant ACE2 and RBD of S protein.	tfdg	15-19	angiotensin converting enzyme 2	Homo sapiens	76-80
35621148-3	2022	The 50% inhibitory concentration (IC50) values were used to determine the inhibitory effect of TFDG and its four monomers for the CYP2C8 activity by recombinant human CYP2C8 (RHCYP2C8) yeast microsome system in vitro, and the volume per dose index (VDI) was predicted the potential inhibition in vivo.	tfdg	95-99	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	130-136
35621148-3	2022	The 50% inhibitory concentration (IC50) values were used to determine the inhibitory effect of TFDG and its four monomers for the CYP2C8 activity by recombinant human CYP2C8 (RHCYP2C8) yeast microsome system in vitro, and the volume per dose index (VDI) was predicted the potential inhibition in vivo.	tfdg	95-99	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	167-173
35621148-9	2022	TFDG had a strong inhibitory effect on CYP2C8 in vitro and in vivo, and also inhibited the metabolism of rosiglitazone in rats.	tfdg	0-4	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	39-45